Premier Hospital Historical Data

Data.gov (United States)

U.S. Department of Health & Human Services — To provide a historical overview of the participating hospitals, before the first project report, Premier Healthcare Informatics has used data already available for...

Analysis of physical match performance in English Premier League soccer referees with particular reference to first half and player work rates.

Science.gov (United States)

Weston, Matthew; Castagna, Carlo; Impellizzeri, Franco M; Rampinini, Ermanno; Abt, Grant

2007-12-01

The aim of the present study was to examine the influence of first half activity, overall match intensity and seasonal variation on the physical match performances of English Premier League football referees. Match analysis data was collected using the Prozone match analysis system from 19 full-time professional referees during a total of 254 matches in the 2004-2005 season. Physical match performances were classified into three separate categories: 1, total distance covered (TD); 2, high-intensity running distance (running speed>5.5m/s, HIR); 3, average distance from infringements (DI). Using these match activity variables the influence of first half TD and HIR distances on second half activities and also the influence of players' match activities upon the referees' physical match performances were examined. The main finding of the present study was that the physical match performances of the referees were partly related to those of the players, in that the referees' HIR correlated with players' HIR (r=0.43, pphysical match performance of the referee. Further examination is required as to whether reduced physical performances in the second half of matches are a consequence of referee fatigue, tactical strategies on behalf of the referee or reduced player match activities resulting in a slower tempo of match.

Diabetes-associated microbiota in fa/fa rats is modified by Roux-en-Y gastric bypass

DEFF Research Database (Denmark)

Arora, Tulika; Seyfried, Florian; Docherty, Neil G

2017-01-01

Roux-en-Y gastric bypass (RYGB) and duodenal jejunal bypass (DJB), two different forms of bariatric surgery, are associated with improved glucose tolerance, but it is not clear whether the gut microbiota contributes to this effect. Here we used fa/fa rats as a model of impaired glucose tolerance...... to investigate whether (i) the microbiota varies between fa/fa and nondiabetic fa/+ rats; (ii) the microbiota of fa/fa rats is affected by RYGB and/or DJB; and (iii) surgically induced microbiota alterations contribute to glucose metabolism. We observed a profound expansion of Firmicutes (specifically......, Lactobacillus animalis and Lactobacillus reuteri) in the small intestine of diabetic fa/fa compared with nondiabetic fa/+ rats. RYGB-, but not DJB-, treated fa/fa rats exhibited greater microbiota diversity in the ileum and lower L. animalis and L. reuteri abundance compared with sham-operated fa/fa rats in all...

Mastering Adobe Premiere Pro CS6

CERN Document Server

Ekert, Paul

2013-01-01

Designed to be practical and engaging, Mastering Adobe Premiere Pro CS6 is a project-based book to help you truly augment your skills and become a film editing hotshot.If you're just starting out or even migrating from existing video editing software, then this book is for you. With rapid progression through practical examples constructed to be both engaging and useful, Mastering Adobe Premiere Pro CS6 is ideal for learning the sometimes complex workflows of this powerful application.

Management and marketing of sporting events: Nike Premier Cup Project

OpenAIRE

Nedbal, Jakub

2008-01-01

Title: Management and marketing ofsporting events: Nike Premier Cup project Points of thesis: Publish the Nike Premier Cup promotion campaign project and point out improvement possibilities for upcoming years based on analysis ofpast and present state. Methods: Data will be obtained by interview, observation, description analysis and SWOT analysis Results: Promotion campaign, improvement possibilities, final day schedule Keywords: SWOT analysis, promotion, management, marketing, Nike Premier ...

What Happens When Employers are Free to Discriminate? Evidence from the English Barclays Premier Fantasy Football League

OpenAIRE

Bryson, Alex; Chevalier, Arnaud

2014-01-01

Research on employers' hiring discrimination is limited by the unlawfulness of such activity. Consequently, researchers have focused on the intention to hire. Instead, we rely on a virtual labour market, the Fantasy Football Premier League, where employers can freely exercise their taste for racial discrimination in terms of hiring and firing. The setting allows us to eliminate co-worker, consumer-based and statistical discrimination as potential sources of discrimination, thus isolating the ...

The Arabic Hyperbolic Pattern "Fa??al" in Two Recent Translations of the Qur'an

Science.gov (United States)

El-Zawawy, Amr M.

2014-01-01

The present study addresses the problem of rendering the ?? ?? 'fa??al' hyperbolic pattern into English in two recent translations of the Qur'an. Due to the variety of Qur'an translations and the large amount of hyperbolic forms of Arabic verbs recorded in the Qur'an, only two translations of the Qur'an are consulted and analyzed: these two…

Policy Advice to Alberta’s New Premier

Directory of Open Access Journals (Sweden)

Jack M. Mintz

2014-09-01

Full Text Available On September 6th, 2014, members of the Progressive Conservative Party of Alberta elected Jim Prentice as leader of their party, and Premier of Alberta. The School of Public Policy assembled its key thinkers in economic, taxation, energy and natural resource policy to provide unsolicited but important advice to Premier Prentice on some areas of policy that matter most to Alberta, and that will demand the Premier’s attention as he takes office. These are opinion pieces, are not peer reviewed, and reflect the views of their authors alone.

John Terry and the Predicament of Englishness: Ambivalence and Nostalgia in the Premier League Era.

OpenAIRE

Ewen, Neil

2013-01-01

This article examines media discourse surrounding the Chelsea and England footballer John Terry and argues that his iconicity embodies multiple anxieties about Englishness and English football in the era of neoliberalism. In a nostalgic culture in search of ‘traditional’ English heroes, Terry is celebrated for his physicality and traditionally ‘English’ style of play; yet, his off-field behaviour is seen to be both emblematic and symptomatic of a celebrity culture considered to betray the val...

Some examples of external colouration on English brick buildings, c. 1500-1650 Étude de façades peintes de palais anglais, entre 1500 et 1650

Directory of Open Access Journals (Sweden)

Jonathan Foyle

2008-06-01

Full Text Available De études récentes réalisées sur les palais de Hampton Court et Kew Palace ont révélé l’histoire de la couleur des façades. Deux approches successives ont pu être définies. Au xvie siècle, on choisit de simuler une façade de brique par l’emploi de peintures rouge, blanche et noire. Cet usage met en avant la brique dans toute sa dimension décorative. Au xviie siècle, on s’intéresse plutôt à l’usage d’un enduit ocre rouge uniforme appelé « ruddle ». Cette pratique efface la présence de la brique et accentue l’impression d’homogénéité et de « monolithisme » des bâtiments. Cette intervention examine les origines possibles de ces traditions et expose les conséquences du rétablissement de la technique du « ruddling » à Kew Palace.The application of coloured limewashes as external surface finishes on many historic English buildings largely determined the original appearance and intended effect of their architecture. As the final stage in the process of construction, limewashes were more than the thin cosmetics which created the skin‑deep beauty of the building; they could articulate and emphasize chosen architectural elements, or conversely suppress the busy individual units of mural masonry in favour of revealing the entire building in a monolithic homogeneity of colour and texture. This paper examines some English brick buildings of c. 1500‑1650 with which the author is familiar, and asks of the surviving evidence to what extent, how and why colour was applied.

Rapsodie first core manufacture. 1. part: processing plant; Fabrication du premier coeur de rapsodie. Premiere partie: l'atelier de fabrication

Energy Technology Data Exchange (ETDEWEB)

Masselot, Y; Bataller, S; Ganivet, M; Guillet, H; Robillard, A; Stosskopf, F [Commissariat a l' Energie Atomique, Cadarache (France). Centre d' Etudes Nucleaires

1968-07-01

This report is the first in a series of three describing the processes, results and peculiar technical problems related to the manufacture of the first core of the fast reactor Rapsodie. A detailed study of manufacturing processes(pellets, pins, fissile sub-assemblies), the associated testings (raw materials, processed pellets and pins, sub-assemblies before delivery), manufacturing facilities and improvements for a second campaign are described. (author) [French] Ce rapport est le premier d'une serie de trois qui decrivent les procedes, les resultats et les problemes techniques particuliers de la fabrication du du premier coeur de la pile a neutrons rapides Rapsodie. Il comporte une etude detaillee des procedes de fabrication (pastilles, aiguilles, assemblages combustibles) et des methodes de controle associees (matieres premieres, pastilles et aiguilles en cours de fabrication, assemblages fissiles avant livraison), ainsi qu'une decription complete des installations de l'atelier de fabrication et les modifications apportees pour une deuxieme campagne. (auteur)

Doodling the Nerves: Surfacing Language Anxiety Experiences in an English Language Classroom

Science.gov (United States)

Siagto-Wakat, Geraldine

2017-01-01

This qualitative study explored the use of doodling to surface experiences in the psychological phenomenon of language anxiety in an English classroom. It treated the doodles of 192 freshmen from a premier university in Northern Luzon, Philippines. Further, it made use of phenomenological reduction in analysing the data gathered. Findings reveal…

The Role of Internet in Marketing Premiering Movies

OpenAIRE

Tuohimaa, Suvi

2010-01-01

The objective of this thesis was to find out about the role of Internet today in premiering movie marketing and whether Internet is a good tool for it. The hope was to obtain new information provided by moviegoers and to contribute something useful to the art of marketing premiering movies. This thesis was a part of the School of Business and Information Management's Innomajakka-project but did not have an official commissioner, so the topic for the thesis came from the writer's personal and ...

Alterations of local cerebral glucose utilization in lean and obese fa/fa rats after acute adrenalectomy.

Science.gov (United States)

Doyle, P; Rohner-Jeanrenaud, F; Jeanrenaud, B

1994-08-29

An animal model often used to investigate the aetiology of obesity is the genetically obese fa/fa rat. It has many abnormalities, including hyperphagia, hyper-insulinemia, insulin resistance, low cerebral glucose utilization and an overactive hypothalamo-pituitary adrenal (HPA) axis with resulting hypercorticism. Due to the latter consideration, the aim of this work was to study the impact of acute adrenalectomy (ADX) on the local cerebral glucose utilization (LCGU) of lean and obese fa/fa rats. ADX resulted in discrete increases in LCGU of regions common to both lean and obese rats. These common regions were found to belong to be related to the limbic system. Within this system, the LCGU of the brain of obese rats was either normalized to lean sham operated values or increased by ADX to a similar degree in both groups on a percentage basis. It was concluded that the LCGU of both lean and obese animals appears to be negatively regulated, albeit to different extents, by glucocorticoids. Such negative regulation is particularly salient within the limbic system of the lean rat and even more so in the fa/fa rat. It is suggested that the long-term hypercorticism of obese fa/fa rats due to abnormal regulation of the HPA axis may result in a decreased LCGU in limbic and related regions of the brain of fa/fa rats and contribute to the expression of the obese phenotype.

Football versus football: effect of topic on /r/ realization in American and English sports fans.

Science.gov (United States)

Love, Jessica; Walker, Abby

2013-12-01

Can the topic of a conversation, when heavily associated with a particular dialect region, influence how a speaker realizes a linguistic variable? We interviewed fans of English Premier League soccer at a pub in Columbus, Ohio. Nine speakers of British English and eleven speakers of American English were interviewed about their favorite American football and English soccer teams. We present evidence that the soccer fans in this speech community produce variants more consistent with Standard American English when talking about American football than English soccer. Specifically, speakers were overall more /r/-ful (F3 values were lower in rhotic environments) when talking about their favorite American football team. Numeric trends in the data also suggest that exposure to both American and British English, being a fan of both sports, and task may mediate these effects.

FA

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — An Area Forecast (FA) is a forecast of Visual Flight Rules (VFR) clouds and weather conditions over an area as large as the size of several states.

Phonologie et morphosyntaxe de l’anglais dans un produit SIC : le premier module de MACAO Phonologie et morphosyntaxe de l’anglais dans un produit SIC : le premier module de MACAO

Directory of Open Access Journals (Sweden)

Laurence Vincent-Durroux

2002-12-01

Full Text Available La préoccupation fréquente, chez les étudiants spécialistes d’autres disciplines que l’anglais, d’améliorer leur compréhension de l’anglais oral a motivé notre démarche de création d’un produit SIC (Systèmes d’Information et de Communication : MACAO (Modules d’Aide à la Compréhension de l’Anglais Oral. Le premier module, "S’entraîner à la reconnaissance", est réalisé et l’outil informatique s’est révélé particulièrement utile pour notre projet. Dans cet article, nous faisons état des difficultés récurrentes en compréhension de l’anglais oral : elles peuvent être dues à des attentes erronées fondées sur la dissymétrie entre la langue écrite et la langue orale, mais aussi à une reconnaissance difficile de certains morphèmes par l’existence de variantes phonologiques en fonction du contexte et par la proximité phonologique de certains morphèmes. Nous présentons également comment le contenu du premier module tente d’apporter des solutions à ces difficultés : en amenant les apprenants à prendre conscience du phénomène de réduction vocalique et d’inaccentuation qui touche certaines syllabes des mots aussi bien que certains éléments monosyllabiques de l’énoncé et en proposant un entraînement à la reconnaissance de ces éléments. Le module est en cours de validation avec une phase d’évaluation.French students who have English as part of their curriculum often express the wish to improve their comprehension of oral English. This led us to envisage the creation of a CALL product: MACAO (Modules to help in the comprehension of oral English. The first module has been created: "Training oneself for recognition". The computer was particularly adequate in this prospect. In this paper we present the most frequent difficulties in the comprehension of oral English: they can be related either to erroneous expectations based on the dissymmetry between the written form and the oral

Time to Detection with BacT/Alert FA Plus Compared to BacT/Alert FA Blood Culture Media.

Science.gov (United States)

Nutman, A; Fisher Even-Tsur, S; Shapiro, G; Braun, T; Schwartz, D; Carmeli, Y

2016-09-01

Rapid identification of the causative pathogen in patients with bacteremia allows adjustment of antibiotic therapy and improves patient outcomes. We compared in vitro and real-life time to detection (TTD) of two blood culture media, BacT/Alert FA (FA) and BacT/Alert FA Plus (FA Plus), for the nine most common species of bacterial pathogens recovered from blood samples. Experimental data from simulated cultures was compared with microbiology records of TTD for both culture media with growth of the species of interest in clinical blood cultures. In the experimental conditions, median TTD was 3.8 hours (23.9 %) shorter using FA Plus media. The magnitude of reduction differed between species. Similarly, in real life data, FA Plus had shorter TTD than FA media; however, the difference between culture media was smaller, and median TTD was only 1 hour (8.5 %) less. We found shorter TTD with BacT/Alert FA Plus culture media, both experimentally and in real-life conditions and unrelated to antibiotic neutralization, highlighting the importance of appropriate blood culture media selection.

Non-operative management of a complete anterior cruciate ligament injury in an English Premier League football player with return to play in less than 8 weeks: applying common sense in the absence of evidence

Science.gov (United States)

Weiler, Richard; Monte-Colombo, Mathew; Mitchell, Adam; Haddad, Fares

2015-01-01

This case report illustrates and discusses the non-operative management of a complete anterior cruciate ligament (ACL) injury in an English Premier League football player, his return to play within 8 weeks and problem-free follow-up at 18 months post injury. When non-operative verses surgical ACL reconstruction is considered there are many fundamental gaps in our knowledge and currently, at elite level, there are no cases in cutting sports within the literature to guide these decisions. When the norm is for all professional footballers to be recommended surgery, it will be very challenging when circumstances and patient autonomy dictate a conservative approach, where prognosis, end points and risk are unclear and assumed to be high. This case challenges current dogma and provides a starting point for much needed debate about best practice, treatment options, research direction and not just at the elite level of sport. PMID:25917066

The Understanding of English Emotion Words by Chinese and Japanese Speakers of English as a Lingua Franca

DEFF Research Database (Denmark)

Mosekjær, Stine

In this thesis I investigate the understanding and use of the English emotion words guilty, ashamed, and proud by Japanese and Chinese speakers of English as a lingua franca. By exploring empirical data I examine (1) how Japanese and Chinese participants understand and use the three stimulus words......, (2) if their understanding and use differ from that of native English speakers, and (3) if so, what these differences are. In the thesis 65 participants are investigated. The participants consist of 20 native Japanese and 23 native Chinese. For comparison, a group of 22 British native English....... The framework, which is based on the theoretical notion of the word as an image-idea pair as suggested by the theory of linguistic supertypes, consists of three tests each addressing three different aspects of the understanding and use of the stimulus words: the Free Association test (FA test), the Context...

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.

Science.gov (United States)

Leung, Justin Wai Chung; Wang, Yucai; Fong, Ka Wing; Huen, Michael Shing Yan; Li, Lei; Chen, Junjie

2012-03-20

The Fanconi anemia (FA) pathway participates in interstrand cross-link (ICL) repair and the maintenance of genomic stability. The FA core complex consists of eight FA proteins and two Fanconi anemia-associated proteins (FAAP24 and FAAP100). The FA core complex has ubiquitin ligase activity responsible for monoubiquitination of the FANCI-FANCD2 (ID) complex, which in turn initiates a cascade of biochemical events that allow processing and removal of cross-linked DNA and thereby promotes cell survival following DNA damage. Here, we report the identification of a unique component of the FA core complex, namely, FAAP20, which contains a RAD18-like ubiquitin-binding zinc-finger domain. Our data suggest that FAAP20 promotes the functional integrity of the FA core complex via its direct interaction with the FA gene product, FANCA. Indeed, somatic knockout cells devoid of FAAP20 displayed the hallmarks of FA cells, including hypersensitivity to DNA cross-linking agents, chromosome aberrations, and reduced FANCD2 monoubiquitination. Taking these data together, our study indicates that FAAP20 is an important player involved in the FA pathway.

Echographie devant une metrorragie du premier trimestre de ...

African Journals Online (AJOL)

Echographie devant une metrorragie du premier trimestre de grossesse sur uterus bicorne a issue favorable. Vaginal bleeding in a pregnant woman with a bicornuate uterus, ultrasound finding and favourable outcome.

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair

Science.gov (United States)

Leung, Justin Wai Chung; Wang, Yucai; Fong, Ka Wing; Huen, Michael Shing Yan; Li, Lei; Chen, Junjie

2012-01-01

The Fanconi anemia (FA) pathway participates in interstrand cross-link (ICL) repair and the maintenance of genomic stability. The FA core complex consists of eight FA proteins and two Fanconi anemia-associated proteins (FAAP24 and FAAP100). The FA core complex has ubiquitin ligase activity responsible for monoubiquitination of the FANCI-FANCD2 (ID) complex, which in turn initiates a cascade of biochemical events that allow processing and removal of cross-linked DNA and thereby promotes cell survival following DNA damage. Here, we report the identification of a unique component of the FA core complex, namely, FAAP20, which contains a RAD18-like ubiquitin-binding zinc-finger domain. Our data suggest that FAAP20 promotes the functional integrity of the FA core complex via its direct interaction with the FA gene product, FANCA. Indeed, somatic knockout cells devoid of FAAP20 displayed the hallmarks of FA cells, including hypersensitivity to DNA cross-linking agents, chromosome aberrations, and reduced FANCD2 monoubiquitination. Taking these data together, our study indicates that FAAP20 is an important player involved in the FA pathway. PMID:22396592

CORPORATE SOCIAL RESPONSIBILITY IN ENGLISH FOOTBALL: HISTORY AND PRESENT

OpenAIRE

Vlad ROŞCA

2011-01-01

The purpose of this descriptive research is to present what kind of corporate social responsibility (CSR) activities English football clubs are implementing. The paper was designed by approaching the examples of the twenty clubs playing in the 2010-2011 season of the Premier League. A key finding is that football clubs are not only interested in the sporting outcome on the field, but they are also aware of their social status. An implication of this research would be to encourage academics to...

The long-term effect of premier pay for performance on patient outcomes.

Science.gov (United States)

Jha, Ashish K; Joynt, Karen E; Orav, E John; Epstein, Arnold M

2012-04-26

Pay for performance has become a central strategy in the drive to improve health care. We assessed the long-term effect of the Medicare Premier Hospital Quality Incentive Demonstration (HQID) on patient outcomes. We used Medicare data to compare outcomes between the 252 hospitals participating in the Premier HQID and 3363 control hospitals participating in public reporting alone. We examined 30-day mortality among more than 6 million patients who had acute myocardial infarction, congestive heart failure, or pneumonia or who underwent coronary-artery bypass grafting (CABG) between 2003 and 2009. At baseline, the composite 30-day mortality was similar for Premier and non-Premier hospitals (12.33% and 12.40%, respectively; difference, -0.07 percentage points; 95% confidence interval [CI], -0.40 to 0.26). The rates of decline in mortality per quarter at the two types of hospitals were also similar (0.04% and 0.04%, respectively; difference, -0.01 percentage points; 95% CI, -0.02 to 0.01), and mortality remained similar after 6 years under the pay-for-performance system (11.82% for Premier hospitals and 11.74% for non-Premier hospitals; difference, 0.08 percentage points; 95% CI, -0.30 to 0.46). We found that the effects of pay for performance on mortality did not differ significantly among conditions for which outcomes were explicitly linked to incentives (acute myocardial infarction and CABG) and among conditions not linked to incentives (congestive heart failure and pneumonia) (P=0.36 for interaction). Among hospitals that were poor performers at baseline, mortality was similar in the two groups of hospitals at the start of the study (15.12% and 14.73%; difference, 0.39 percentage points; 95% CI, -0.36 to 1.15), with similar rates of improvement per quarter (0.10% and 0.07%; difference, -0.03 percentage points; 95% CI, -0.08 to 0.02) and similar mortality rates at the end of the study (13.37% and 13.21%; difference, 0.15 percentage points; 95% CI, -0.70 to 1.01). We

Metformin ameliorates diabetes but does not normalize the decreased GLUT 4 content in skeletal muscle of obese (fa/fa) Zucker rats

DEFF Research Database (Denmark)

Handberg, A; Kayser, L; Høyer, P E

1993-01-01

We studied the expression of the glucose transporter GLUT 4 in the soleus and red gastrocnemius muscles from obese, diabetic (fa/fa) Zucker rats compared to their lean littermates (Fa/-), with and without treatment with the antidiabetic drug metformin. In the untreated groups of rats, the GLUT 4...... content in a crude membrane fraction of both the soleus and the red gastrocnemius muscles were significantly lower in the obese (fa/fa) rats (3.46 +/- 0.28 vs. 6.04 +/- 0.41, p ... the same rats were confirmed by quantitative immunofluorescence microscopy, and the results were significantly correlated with the results obtained from quantitative immunoblotting (rho = 0.70, p fa/fa rats could contribute to the well-established insulin...

International Façades - CROFT. Climate Related Optimized Façade Technologies

Directory of Open Access Journals (Sweden)

Marcel Bilow

2012-04-01

Full Text Available Looking at Central European building projects illustrates an awareness of sustainability and the need to save energy. This trend is based on the finiteness of natural resources, and is thus wise to follow. Developments in this region including passive house technologies, and energy plus solutions that create more energy than they use have become realisable. But it is not increasing technological knowledge alone that supported these developments; the Central European climate makes it possible to invent technological solutions that allow for maximum comfort while maintaining low energy consumption. Other regions have experienced a building boom over the past decades that has dramatically increased city sizes. A detailed examination of such building projects illustrates that most of them strive for the international standard with a high glazing ratio in the style of the Central European examples. But how can architecture be transferred to regions with entirely different climate conditions? The answer lies in the technological possibilities we have at our disposal today. The main research question of this thesis refers to utilising the local climate. Which methods are necessary to plan a building - and a façade as the interface between the inside and the outside, in particular - while working with, not against the climate? Sailing has been used as an analogy: only with the knowledge of winds and tides can we use them to efficiently move across bodies of water. Those who have not learned or understood this will have to use a motorboat and pay the price for petrol. Chapter 2 ‘Climate zones’ describes the different climate zones and their particularities, analysed with the help of eight different boomtowns. The mild Central European climate becomes particularly apparent when compared to tropic locations such as Singapore. Here, very high average temperatures and humidity levels require that we rethink and find new solutions. In chapter 3 �

Language Preference among Nigerian Undergraduates and the Future of English

Directory of Open Access Journals (Sweden)

Gabriel B. Egbe

2014-12-01

Full Text Available What will be the future of English in Nigeria? Put more apprehensively, will the English language die in Nigeria in the near future? These questions are answered by reporting on the language preference at home of some Nigerian undergraduates in order to gauge the future of English in Nigeria. The investigation sought to determine the language(s most preferred for communication at home among Nigerian undergraduates. From a sample drawn from students in a private Nigerian university, 66.7% identified English as the most frequently used language at home while 64.1% indicated fluency in English against other languages spoken in Nigeria including the indigenous major Nigerian languages (Hausa, Igbo and Yoruba. On order of fluency among the languages sampled, 18.5% indicated an English-only fluency, which reveals that some section of young Nigerians are moving towards a monolingual English-only proficiency. This discovery has implications for the future of English in Nigeria. Several factors may account for this emerging trend. However, the premier position occupied by English in Nigeria and the expanding use of English world-wide clearly support the continuous growth and visibility of English as the language of choice among Nigerian undergraduates at home. This is without prejudice to several declarations and policy statements in favour of Mother Tongue education and usage in Nigeria. The paper concludes that the emergence of a new generation of Nigerians who use English as a first language in a non-host second language context is sowing the seed for further nativization and entrenchment of English in Nigeria.

What’s a Cricketer’s Worth? Predicting Bid Prices for Indian Premier League Auctions

Directory of Open Access Journals (Sweden)

Siddhartha K. RASTOGI

2017-04-01

Full Text Available Indian Premier League is a twenty-over format cricket tournament of teams representing different Indian cities. Beginning 2008, it is established now as a grand annual affair. The team franchises are auctioned on long term basis, whereas cricketers are auctioned every season under certain conditions. Despite such wealth of information, studies on IPL auctions are rare barring four cited models. The present paper studies the results of year 2011 English-style auction of cricketers and recalibrates the old yet most accurate model by Rastogi and Deodhar (2009. Both models use ordinary least square method of regression albeit with different variable. The old models lack predictive power, whereas the recalibrated model presented displays better predictive capability as compared to earlier models. It also succeeds in reducing overall predictability gap and stands significantly parsimonious vis-à-vis previous models. Further, the final model presented is applied on 2013 and 2014 auction data to show superior results.

DICTIONARIES LOOKUP STRATEGIES FOR ARABIC-ENGLISH TRANSLATION

Directory of Open Access Journals (Sweden)

Mohammad Ahmad THAWABTEH

2013-05-01

Full Text Available Bien que les dictionnaires ont une extrême importance dans les cours de traduction, on les considère comme une épée à double tranchant. De grotesques traductions indiquent clairement que les étudiants utilisent les dictionnaires d’une façon incompétente. Les données de cette étude représentent les traductions d’une vingtaine d’étudiants de premier cycle d’Anglais à l’université d’Al-quds et l’université de Palestine Ahlyia. Les traductions sont examinées à base des stratégies de recherche en dictionnaire. Les résultats de l’étude montrent que les pièges des sorties de la traduction que les étudiants font sont dus au: 1-la dépendance exagérée du dictionnaire. 2- le manque de compréhension du texte dans sa langue d’origine. 3- le fait de choisir le premier sens. 4- le peu d’attention accordée aux exemples illustrés dans le dictionnaire. 5- favoriser la lecture attentive sur la lecture superficielle. 6- ignorance totale des collocations, des idioms, et des proverbes. 7- l’incapacité de comprendre le sens du contexte. Quelques stratégies de recherche dans le dictionnaire qui peuvent aider les étudiants de traduction à effectuer leur travail rapidement et efficacement sont proposées.

How to Revise, and Revise Really Well, for Premier Academic Journals

DEFF Research Database (Denmark)

LaPlaca, Peter J.; Lindgreen, Adam; Vanhamme, Joelle

2018-01-01

Most of the premier academic journals in all fields routinely have rejection rates of 80%, 95%, or higher. All journals prefer articles that make significant contributions to the field. Revising a manuscript and responding properly to the comments of reviewers and editors often is challenging....... This article discusses how to revise effectively a manuscript according to the (minor or major) comments of reviewers and editors for premier academic journals. We provide a series of tips for helping the authors in their endeavor, making the process less arduous and improving the possibility of a positive...

A protein prioritization approach tailored for the FA/BRCA pathway.

Directory of Open Access Journals (Sweden)

Anneke Haitjema

Full Text Available Fanconi anemia (FA is a heterogeneous recessive disorder associated with a markedly elevated risk to develop cancer. To date sixteen FA genes have been identified, three of which predispose heterozygous mutation carriers to breast cancer. The FA proteins work together in a genome maintenance pathway, the so-called FA/BRCA pathway which is important during the S phase of the cell cycle. Since not all FA patients can be linked to (one of the sixteen known complementation groups, new FA genes remain to be identified. In addition the complex FA network remains to be further unravelled. One of the FA genes, FANCI, has been identified via a combination of bioinformatic techniques exploiting FA protein properties and genetic linkage. The aim of this study was to develop a prioritization approach for proteins of the entire human proteome that potentially interact with the FA/BRCA pathway or are novel candidate FA genes. To this end, we combined the original bioinformatics approach based on the properties of the first thirteen FA proteins identified with publicly available tools for protein-protein interactions, literature mining (Nermal and a protein function prediction tool (FuncNet. Importantly, the three newest FA proteins FANCO/RAD51C, FANCP/SLX4, and XRCC2 displayed scores in the range of the already known FA proteins. Likewise, a prime candidate FA gene based on next generation sequencing and having a very low score was subsequently disproven by functional studies for the FA phenotype. Furthermore, the approach strongly enriches for GO terms such as DNA repair, response to DNA damage stimulus, and cell cycle-regulated genes. Additionally, overlaying the top 150 with a haploinsufficiency probability score, renders the approach more tailored for identifying breast cancer related genes. This approach may be useful for prioritization of putative novel FA or breast cancer genes from next generation sequencing efforts.

The Arabic Hyperbolic Pattern 'Fa??al' in Two Recent Translations of the Qur'an

Directory of Open Access Journals (Sweden)

Amr M. El-Zawawy

2014-06-01

Full Text Available The present study addresses the problem of rendering the فعال'fa??al' hyperbolic pattern into English in two recent translations of the Qur'an. Due to the variety of Qur'an translations and the large amount of hyperbolic forms of Arabic verbs recorded in the Qur'an, only two translations of the Qur'an are consulted and analyzed: these two translations, namely Saheeh International Translation (1997 and Prof. Abdel-Haleem's (2004, are distinguished by the fact that they are recent and well-received. Moreover, the investigation of hyperbolic forms is confined to the Arabic formفعال    'fa??al'. The study reveals that the Saheeh translator has applied morphological shifting in many examples while Abdel-Haleem's translation exhibits a considerable amount of syntactic transposition, coupled with paraphrasing. The test of accuracy as administered here is to give a clear picture of the need to pay particular attention to hyperboles of the form examined and other ones not analyzed here for limitations of space.

Scottish Premier League Reading Stars Evaluation Report

Science.gov (United States)

National Literacy Trust, 2009

2009-01-01

Scottish Premier League (SPL) Reading Stars uses the motivational power of football to attract families who need support with literacy into a positive and friendly learning environment. It ran for the first time between March and August 2009 and attracted 225 children and 190 adults to take part in a series of inspirational learning sessions in 23…

Open Access Publishing in Indian Premier Research Institutions

Science.gov (United States)

Bhat, Mohammad Hanief

2009-01-01

Introduction: Publishing research findings in open access journals is a means of enhancing visibility and consequently increasing the impact of publications. This study provides an overview of open access publishing in premier research institutes of India. Method: The publication output of each institution from 2003 to 2007 was ascertained through…

Benchmarking of FA2D/PARCS Code Package

International Nuclear Information System (INIS)

Grgic, D.; Jecmenica, R.; Pevec, D.

2006-01-01

FA2D/PARCS code package is used at Faculty of Electrical Engineering and Computing (FER), University of Zagreb, for static and dynamic reactor core analyses. It consists of two codes: FA2D and PARCS. FA2D is a multigroup two dimensional transport theory code for burn-up calculations based on collision probability method, developed at FER. It generates homogenised cross sections both of single pins and entire fuel assemblies. PARCS is an advanced nodal code developed at Purdue University for US NRC and it is based on neutron diffusion theory for three dimensional whole core static and dynamic calculations. It is modified at FER to enable internal 3D depletion calculation and usage of neutron cross section data in a format produced by FA2D and interface codes. The FA2D/PARCS code system has been validated on NPP Krsko operational data (Cycles 1 and 21). As we intend to use this code package for development of IRIS reactor loading patterns the first logical step was to validate the FA2D/PARCS code package on a set of IRIS benchmarks, starting from simple unit fuel cell, via fuel assembly, to full core benchmark. The IRIS 17x17 fuel with erbium burnable absorber was used in last full core benchmark. The results of modelling the IRIS full core benchmark using FA2D/PARCS code package have been compared with reference data showing the adequacy of FA2D/PARCS code package model for IRIS reactor core design.(author)

Mass spectrometry of the lithium adducts of diacylglycerols containing hydroxy FA in castor oil and two normal FA

Science.gov (United States)

Castor oil can be used in industry. The molecular species of triacylglycerols containing hydroxy fatty acids (FA) in castor oil have been identified. We report here the identification of twelve diacylglycerols (DAG) containing hydroxy FA in castor oil using positive ion electrospray ionization mass ...

Logistique de transport pour le projet LHC enseignements des premiers secteurs

CERN Document Server

Prodon, S

2003-01-01

Ce papier dresse un premier bilan de la logistique de transport mise en place pour l'installation du LHC. Les moyens de planification mis en oeuvre seront tout d'abord évoqués avec notamment les réunions avec les groupes utilisateurs, l'élaboration de procédures de transport, la génération de listings d'articles à transporter ou encore l'établissement d'un planning des ressources. Cependant, les premiers travaux d'installation du LHC ont fait apparaître des divergences importantes entre le planning logistique établi et la réalité du terrain. Ces écarts seront analysés, qu'il s'agisse de différences sur le volume de matériel à acheminer, d'opérations non planifiées, de changements de plannings entraînant de longues et délicates traversées de chantiers ou de manque de planification des besoins en personnel dans certaines zones. Tous ces enseignements acquis au cours des premiers travaux devraient permettre de dégager des voies d'amélioration à mettre en place pour les prochains secteur...

ming-fa hsieh

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. MING-FA HSIEH. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1179-1187. Preparation, characterization of chitosan/bamboo charcoal/poly(methacrylate) composite beads · DOROTHY CAMINOS-PERUELO WEI-CHIEH WANG ...

Framework for benchmarking FA-based string recognizers

CSIR Research Space (South Africa)

Ngassam, EK

2010-10-01

Full Text Available of suggested algorithms by domain-specific FA-implementers requires prior knowledge of the behaviour (performance-wise) of each algorithm in order to make an informed choice. The authors propose a based string recognizers such that FA-implementers could capture...

Physiological response of one of South Africa's premier freshwater ...

African Journals Online (AJOL)

Physiological response of one of South Africa's premier freshwater sport angling species, the Orange-Vaal smallmouth yellowfish Labeobarbus aeneus, ... These data suggest that catch-and-release causes physiological stress to fish, but nonetheless this practice can be a valuable fisheries management tool to ensure the ...

FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA

Energy Technology Data Exchange (ETDEWEB)

Ali, Abdullah Mahmood; Singh, Thiyam Ramsing [Division of Experimental Hematology and Cancer Biology, Cincinnati Children' s Research Foundation, Cincinnati Children' s Hospital Medical Center, Cincinnati, OH 45229 (United States); Meetei, Amom Ruhikanta, E-mail: Ruhikanta.Meetei@cchmc.org [Division of Experimental Hematology and Cancer Biology, Cincinnati Children' s Research Foundation, Cincinnati Children' s Hospital Medical Center, Cincinnati, OH 45229 (United States); Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 (United States)

2009-07-31

Fanconi anemia (FA) is a rare autosomal recessive or X-linked disorder characterized by aplastic anemia, cancer susceptibility and cellular sensitivity to DNA-crosslinking agents. Eight FA proteins (FANCA, -B, -C, -E, -F, -G, -L and -M) and three non-FA proteins (FAAP100, FAAP24 and HES1) form the FA nuclear core complex that is required for monoubiquitination of the FANCD2-FANCI dimer upon DNA damage. The other three FA proteins, FANCD1/BRCA2, FANCJ/BACH1/BRIP1 and FANCN/PALB2, act in parallel or downstream of the FANCD2-FANCI dimer. Despite the isolation and characterization of several FA proteins, the mechanism by which these proteins protect cells from DNA interstrand crosslinking agents has been unclear. This is because a majority of the FA proteins lack any recognizable functional domains that can provide insight into their function. The recently discovered FANCM (Hef) and FANCJ (BRIP1/BACH1) proteins contain helicase domains, providing potential insight into the role of FA proteins in DNA repair. FANCM with its partner, FAAP24, and FANCJ bind and metabolize a variety of DNA substrates. In this review, we focus on the discovery, structure, and function of the FANCM-FAAP24 and FANCJ proteins.

FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA

International Nuclear Information System (INIS)

Ali, Abdullah Mahmood; Singh, Thiyam Ramsing; Meetei, Amom Ruhikanta

2009-01-01

Fanconi anemia (FA) is a rare autosomal recessive or X-linked disorder characterized by aplastic anemia, cancer susceptibility and cellular sensitivity to DNA-crosslinking agents. Eight FA proteins (FANCA, -B, -C, -E, -F, -G, -L and -M) and three non-FA proteins (FAAP100, FAAP24 and HES1) form the FA nuclear core complex that is required for monoubiquitination of the FANCD2-FANCI dimer upon DNA damage. The other three FA proteins, FANCD1/BRCA2, FANCJ/BACH1/BRIP1 and FANCN/PALB2, act in parallel or downstream of the FANCD2-FANCI dimer. Despite the isolation and characterization of several FA proteins, the mechanism by which these proteins protect cells from DNA interstrand crosslinking agents has been unclear. This is because a majority of the FA proteins lack any recognizable functional domains that can provide insight into their function. The recently discovered FANCM (Hef) and FANCJ (BRIP1/BACH1) proteins contain helicase domains, providing potential insight into the role of FA proteins in DNA repair. FANCM with its partner, FAAP24, and FANCJ bind and metabolize a variety of DNA substrates. In this review, we focus on the discovery, structure, and function of the FANCM-FAAP24 and FANCJ proteins.

Les faïences patronymiques

Directory of Open Access Journals (Sweden)

Jean Rosen

2006-09-01

Full Text Available Les faïences patronymiques, collection Jeanne Lemerle - Donation Michel Dillange,J. Rosen (dir., D. Donadieu-Rigaut, J.-M. Roudier, S. Biton, A. Supiot,Le Mans, éd. de la Reinette, 2006, 158 p.A la suite d’une récente donation, le Musée de l’Abbaye Sainte-Croix des Sables-d’Olonne présente un exceptionnel ensemble de cent soixante-cinq faïences patronymiques nivernaises rassemblé dans les années 1930-1940, ensemble très complet produit des environs de 1730 aux années 1830, qui constitue un p...

Premiere toob lavale jalgpallimeeskonna, inimkatsed ja punase tooli / Kairi Prints

Index Scriptorium Estoniae

Prints, Kairi, 1977-

2012-01-01

Premiere 2012 osalevad neli Eesti tantsukunstnikku: Svetlana Grigorjeva tantsulavastusega "sõp rus est", Kaisa Selde, Kristina-Maria Heinsalu ja Christin Lunts tantsulavastusega "fie", esmakordselt võtab osa välismaalane - sakslanna Mareike Franz tantsulavastusega "Duett". Kõik esietenduvad 9. veebruaril Kanuti gildi saalis

A protein prioritization approach tailored for the FA/BRCA pathway

NARCIS (Netherlands)

Haitjema, A.; Brandt, B.W.; Ameziane, N.; May, P.; Heringa, J.; de Winter, J.P.; Joenje, H.; Dorsman, J.C.

2013-01-01

Fanconi anemia (FA) is a heterogeneous recessive disorder associated with a markedly elevated risk to develop cancer. To date sixteen FA genes have been identified, three of which predispose heterozygous mutation carriers to breast cancer. The FA proteins work together in a genome maintenance

A Protein Prioritization Approach Tailored for the FA/BRCA Pathway

NARCIS (Netherlands)

Haitjema, A.; Brandt, B.W.; Ameziane, N.; May, P.; Heringa, J.; de Winter, J.P.; Joenje, H.; Dorsman, J.C.

2013-01-01

Fanconi anemia (FA) is a heterogeneous recessive disorder associated with a markedly elevated risk to develop cancer. To date sixteen FA genes have been identified, three of which predispose heterozygous mutation carriers to breast cancer. The FA proteins work together in a genome maintenance

The impact of dermatology in premier medicine journals.

Science.gov (United States)

Kheterpal, Meenal K; Ellis, Charles N

2011-01-01

In the past 15 years, research in dermatology has significantly increased. Dermatology-related contributions in premier medical journals such as The New England Journal of Medicine (NEJM) and The Journal of the American Medical Association (JAMA) are the representation of our field in the medical world. To analyze this representation, incidence of dermatology-related contributions in NEJM and JAMA during 3 separate years (during a 15-year period) was calculated.

Opuntia ficus indica (nopal) attenuates hepatic steatosis and oxidative stress in obese Zucker (fa/fa) rats.

Science.gov (United States)

Morán-Ramos, Sofía; Avila-Nava, Azalia; Tovar, Armando R; Pedraza-Chaverri, José; López-Romero, Patricia; Torres, Nimbe

2012-11-01

Nonalcoholic fatty liver disease (NAFLD) is associated with multiple factors such as obesity, insulin resistance, and oxidative stress. Nopal, a cactus plant widely consumed in the Mexican diet, is considered a functional food because of its antioxidant activity and ability to improve biomarkers of metabolic syndrome. The aim of this study was to assess the effect of nopal consumption on the development of hepatic steatosis and hepatic oxidative stress and on the regulation of genes involved in hepatic lipid metabolism. Obese Zucker (fa/fa) rats were fed a control diet or a diet containing 4% nopal for 7 wk. Rats fed the nopal-containing diet had ∼50% lower hepatic TG than the control group as well as a reduction in hepatomegaly and biomarkers of hepatocyte injury such as alanine and aspartate aminotransferases. Attenuation of hepatic steatosis by nopal consumption was accompanied by a higher serum concentration of adiponectin and a greater abundance of mRNA for genes involved in lipid oxidation and lipid export and production of carnitine palmitoyltransferase-1 and microsomal TG transfer proteins in liver. Hepatic reactive oxygen species and lipid peroxidation biomarkers were significantly lower in rats fed nopal compared with the control rats. Furthermore, rats fed the nopal diet had a lower postprandial serum insulin concentration and a greater liver phosphorylated protein kinase B (pAKT):AKT ratio in the postprandial state. This study suggests that nopal consumption attenuates hepatic steatosis by increasing fatty acid oxidation and VLDL synthesis, decreasing oxidative stress, and improving liver insulin signaling in obese Zucker (fa/fa) rats.

Trichoberoard gastrique : Premier cas observe en milieu bur kina be ...

African Journals Online (AJOL)

Le trichobezoard est une concretion de cheveux, de poils ou de fibres de tapis et de debris alimentaire, localisee habituellement dans l'estomac. Le trichobezoard est une pathologie rare qui survient habituellement chez des adolescentes presentant des troubles psychiques. La premiere observation de trichobezoard a ete ...

Designing Urban Media Façades

DEFF Research Database (Denmark)

Dalsgaard, Peter; Halskov, Kim

2010-01-01

Media façades comprise a category of urban computing concerned with the integration of displays into the built environment, including buildings and street furniture. This paper identifies and discusses eight challenges faced when designing urban media façades. The challenges concern a broad range...... of issues: interfaces, physical integration, robustness, content, stakeholders, situation, social relations, and emerging use. The challenges reflect the fact that the urban setting as a domain for interaction design is characterized by a number of circumstances and socio-cultural practices that differ from...

Regulation of palmitoyl-CoA chain elongation by clofibric acid in the liver of Zucker fa/fa rats.

Science.gov (United States)

Toyama, Tomoaki; Kudo, Naomi; Mitsumoto, Atsushi; Kawashima, Yoichi

2005-05-01

The regulation of palmitoyl-CoA chain elongation (PCE) by clofibric acid [2-(4-chlorophenoxy)-2-methylpropionic acid] was investigated in comparison with stearoyl-CoA desaturase (SCD) in the liver of obese Zucker fa/fa rats. The proportion of oleic acid in the hepatic lipids of Zucker obese rats is 2.7 times higher than that of lean littermates. The activities of PCE and SCD in the liver of Zucker obese rats were markedly higher than in lean rats, and the hepatic uptake of 2-deoxyglucose (2-DG) was also higher in Zucker obese rats compared with lean rats. The increased activities of SCD and PCE in Zucker obese rats were due to the enhanced expression of mRNA of both SCD1 and rat FA elongase 2 (rELO2), but not SCD2 or rELO1. The proportion of oleic acid in the liver was significantly increased by the administration of clofibric acid to Zucker obese rats, and the hepatic PCE activity and rELO2 mRNA expression, but not the SCD activity or SCD1 mRNA expression, were increased in response to clofibric acid treatment. By contrast, the activities of both PCE and SCD and the mRNA expression of SCD1 and rELO2 in the liver were increased by the treatment of Zucker lean rats with clofibric acid. Multiple regression analysis, which was performed to determine the relationships involving PCE activity, SCD activity, and the proportion of oleic acid, revealed that the three parameters were significantly correlated and that the standardized partial regression coefficient of PCE was higher than that of SCD. These results indicate that oleic acid is synthesized by the concerted action of PCE and SCD and that PCE plays a crucial role in the formation of oleic acid when Zucker fa/fa rats are given clofibric acid.

CFD Analysis of a Maneuvering F/A-18E Super Hornet

Science.gov (United States)

2016-10-12

tools for aircraft, ships, and radio - frequency antenna design and analysis. The resulting program is called the Computational Research and Engineering...accurately predicting the forces and moments on the F/A-18E Super Hornet while performing several complicated maneuvers. Past F/A-18E computational studies... predicting the forces and moments on the F/A-18E Super Hornet while performing several complicated maneuvers. Past F/A-18E computational studies have

Pengaruh pengolahan terhadap Pati Resisten Pisang Kepok (Musa paradisiaca fa. typica) dan Pisang Tanduk (Musa paradisiaca fa. corniculata)

OpenAIRE

Marsono, Yustinus

2016-01-01

A study on the effect processing on resistant starch (RS) content and chemical composition of kepok (Musa paradisiaca fa. typica) and tanduk banana (Musa paradisiaca fa. corniculata) has been conducted. Mature banana was steamed, steamed - cooled, steamed - frozen, dried and dried - fried and was analyzed for starch, RS, simple sugars and chemical composition. RS content was determined by enzymatic method. It was found that steaming chaned RS from 6.2 mg/g to 9.5 mg/g (53%) for kepok banana a...

Computers for Schools Kenya se classe au premier rang | CRDI ...

International Development Research Centre (IDRC) Digital Library (Canada)

Cinq ans après avoir remis en service ses premiers ordinateurs recyclés et leur avoir trouvé un nouveau nid, l'organisation non gouvernementale Computers for Schools Kenya (CFSK) s'est mérité un prix convoité à l'échelle de l'Afrique pour son travail.

Odenplan: a media façade design process

DEFF Research Database (Denmark)

Korsgaard, Henrik; Hansen, Nicolai Brodersen; Basballe, Ditte Amund

2012-01-01

In this paper we present an example of how to work with the challenges inherent in media façade design processes. We base the paper on our experiences from the creation of a series of design proposals for a media façade on the Odenplan subway station in Stockholm, Sweden. We approach the question...

Multi-angled Façade System for Office Building Renovation

DEFF Research Database (Denmark)

Hannoudi, Loay Akram; Christensen, Jørgen Erik; Lauring, Michael

renovating office buildings. The architectural potential is presented with the help of AutoCAD software. The energy efficiency and indoor climate are investigated and evaluated by using correlational research and simulation research methods with the software IDA ICE. From a functional perspective, the multi......-angled façade increases the area of the office room and provides more space. There are many potential aesthetic benefits provided by multi-angled façades such as improved optical and visual quality from inside the office room and the possibility for daylight penetration and a view to outside from one part...... compared to a renovated flat façade varies between 4.9 and 6.5 kWh/(m2.year), depending on the orientation of the façade. The increase in the office room area, when renovated with a multi-angled façade, is by 19%, while the increase of the yearly primary energy consumption (not area weighted), is by 4...

The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway.

Science.gov (United States)

Polito, David; Cukras, Scott; Wang, Xiaozhe; Spence, Paige; Moreau, Lisa; D'Andrea, Alan D; Kee, Younghoon

2014-03-07

Fanconi anemia (FA) is a genome instability syndrome characterized by bone marrow failure and cellular hypersensitivity to DNA cross-linking agents. In response to DNA damage, the FA pathway is activated through the cooperation of 16 FA proteins. A central player in the pathway is a multisubunit E3 ubiquitin ligase complex or the FA core complex, which monoubiquitinates its substrates FANCD2 and FANCI. FANCE, a subunit of the FA core complex, plays an essential role by promoting the integrity of the complex and by directly recognizing FANCD2. To delineate its role in substrate ubiquitination from the core complex assembly, we analyzed a series of mutations within FANCE. We report that a phenylalanine located at the highly conserved extreme C terminus, referred to as Phe-522, is a critical residue for mediating the monoubiquitination of the FANCD2-FANCI complex. Using the FANCE mutant that specifically disrupts the FANCE-FANCD2 interaction as a tool, we found that the interaction-deficient mutant conferred cellular sensitivity in reconstituted FANCE-deficient cells to a similar degree as FANCE null cells, suggesting the significance of the FANCE-FANCD2 interaction in promoting cisplatin resistance. Intriguingly, ectopic expression of the FANCE C terminus fragment alone in FA normal cells disrupts DNA repair, consolidating the importance of the FANCE-FANCD2 interaction in the DNA cross-link repair.

The Carboxyl Terminus of FANCE Recruits FANCD2 to the Fanconi Anemia (FA) E3 Ligase Complex to Promote the FA DNA Repair Pathway*

Science.gov (United States)

Polito, David; Cukras, Scott; Wang, Xiaozhe; Spence, Paige; Moreau, Lisa; D'Andrea, Alan D.; Kee, Younghoon

2014-01-01

Fanconi anemia (FA) is a genome instability syndrome characterized by bone marrow failure and cellular hypersensitivity to DNA cross-linking agents. In response to DNA damage, the FA pathway is activated through the cooperation of 16 FA proteins. A central player in the pathway is a multisubunit E3 ubiquitin ligase complex or the FA core complex, which monoubiquitinates its substrates FANCD2 and FANCI. FANCE, a subunit of the FA core complex, plays an essential role by promoting the integrity of the complex and by directly recognizing FANCD2. To delineate its role in substrate ubiquitination from the core complex assembly, we analyzed a series of mutations within FANCE. We report that a phenylalanine located at the highly conserved extreme C terminus, referred to as Phe-522, is a critical residue for mediating the monoubiquitination of the FANCD2-FANCI complex. Using the FANCE mutant that specifically disrupts the FANCE-FANCD2 interaction as a tool, we found that the interaction-deficient mutant conferred cellular sensitivity in reconstituted FANCE-deficient cells to a similar degree as FANCE null cells, suggesting the significance of the FANCE-FANCD2 interaction in promoting cisplatin resistance. Intriguingly, ectopic expression of the FANCE C terminus fragment alone in FA normal cells disrupts DNA repair, consolidating the importance of the FANCE-FANCD2 interaction in the DNA cross-link repair. PMID:24451376

Adaptive Façade: Variant-Finding using Shape Grammar

Science.gov (United States)

Tomasowa, Riva; Utama Sjarifudin, Firza

2017-12-01

Modular façade construction has never been better since the birth of computer-aided manufacturing which bridges the modeling phase into the manufacturing phase for escalating the mass production. This comes to a result that the identity of a product or a building façade will commonly generate in the same way that the initial design was intended to. Rectifying the early model will then greatly impact the process later. The aim of this paper is to propose a way to solve these two challenges, without risking the manufacturing process, but more to explore the potential designs. Shape grammar is used to conceive more designs in the early stage, derived from the initial product - the modular adaptive façade system. The derivations are then tested through simulation to state the efficacy of the models. We find that the workflow somehow contributes to the better design and engineering process as well as the solution allows diversification in the façade expressions.

FaPOD27 functions in the metabolism of polyphenols in strawberry fruit (Fragaria sp.

Directory of Open Access Journals (Sweden)

Su-Ying eYeh

2014-10-01

Full Text Available The strawberry (Fragaria × ananassa is one of the most preferred fresh fruit worldwide, accumulates numerous flavonoids but has limited shelf life due to excessive tissue softening caused by cell wall degradation. Since lignin is one of the polymers that strengthen plant cell walls and might contribute to some extent to fruit firmness monolignol biosynthesis was studied in strawberry fruit. Cinnamoyl-CoA reductase (CCR, cinnamyl alcohol dehydrogenase (CAD, and a peroxidase (POD27 gene were strongly expressed in red, ripe fruit whereas a second POD gene was primarily expressed in green, immature fruit. Moreover, FaPOD27 transcripts were strongly and constitutively induced in fruits exposed to Agrobacterium infection. Gene expression levels and enzymatic activities of FaCCR and FaCAD were efficiently suppressed through RNAi in FaCCR- and FaCAD-silenced strawberries. Besides, significantly elevated FaPOD transcript levels were detected after agroinfiltration of pBI-FaPOD constructs in fruits. At the same time, levels of G-monomers were considerably reduced in FaCCR-silenced fruits whereas the proportion of both G- and S-monomers decisively decreased in FaCAD-silenced and pBI-FaPOD fruits. Development, firmness, and lignin level of the treated fruits were similar to pBI-intron control fruits, presumably attributed to increased expression levels of FaPOD27 upon agroinfiltration. Additionally, enhanced firmness, accompanied with elevated lignin levels, was revealed in chalcone synthase-deficient fruits (CHS-, independent of down- or up-regulation of individual and combined FaCCR, FaCAD, and FaPOD genes by agroinfiltration, when compared to CHS-/pBI-intron control fruits. These approaches provide further insight into the genetic control of flavonoid and lignin synthesis in strawberries. The results suggest that FaPOD27 is a key gene for lignin biosynthesis in strawberry fruit and thus to improving the firmness of strawberries.

Global emissions of the hydrofluorocarbons (HFCs) HFC-365mfc, HFC-245fa, HFC-227ea, and HFC-236fa based on atmospheric observations

Science.gov (United States)

Vollmer, M. K.; Miller, B. R.; Rigby, M. L.; Reimann, S.; Muhle, J.; Agage, Soge, Snu Members, Kopri Members

2010-12-01

We report on the atmospheric measurements and global emissions of the hydrofluorocarbons (HFCs) HFC-365mfc (CH3CH2CF2CF3, 1,1,1,3,3-pentafluorobutane), HFC-245fa (CHF2CH2CF3, 1,1,1,3,3-pentafluoropropane), HFC-227ea (CF3CHFCF3, 1,1,1,2,3,3,3-heptafluoropropane), and HFC-236fa (CF3CH2CF3, 1,1,1,3,3,3-hexafluoropropane). These measurements are from in-situ observations at stations of AGAGE (Advanced Global Atmospheric Gases Experiment) and SOGE (System for Observations of Halogenated Greenhouse Gases in Europe), and from the Korean station Gosan. We also report on flask sample measurements from the Antarctic stations King Sejong and Troll, and extend our records back to the 1970s using archived air samples of both hemispheres. All data are used in a global 12-box 2-dimensional atmospheric transport model to derive global abundances and emission estimates. All four HFCs have strongly increased in the atmosphere in recent years with growth rates at nearly 10 %, resulting in dry air mole fractions at the end of 2009 of 0.49 ppt for HFC-365mfc, 1.00 ppt for HFC-245fa, and 0.51 ppt for HFC-227ea. HFC-236fa, for which we report the first atmospheric measurements, is less abundant and has grown to 0.069 ppt at the end of 2009. Our model results show rapidly growing emissions of HFC-365mfc and HFC-245fa after 2002 but surprisingly these have now started to decline to globally 2.7 kt/yr (HFC-365mfc) and 6.1 kt/yr (HFC-245fa). On the other hand HFC-227ea and HFC-236fa show uninterrupted growth in their emissions of 2.5 kt/yr and 0.2 kt/yr at the end of 2009.

A narrative synthesis of the applicability of the CaR-FA-X model in child and adolescent populations: a systematic review.

Science.gov (United States)

Stewart, Tracy M; Hunter, Simon C; Rhodes, Sinéad M

2017-10-01

The CaR-FA-X model [Williams, J. M. G., Barnhofer, T., Crane, C., Hermans, D., Raes, F., Watkins, E., … Dalgleish, T. (2007). Autobiographical memory specificity and emotional disorder. Psychological Bulletin, 133(1), 122-148. doi: 10.1037/0033-2909.133.1.122 ] is the most prominent and comprehensive model of overgeneral autobiographical memory (OGM) and provides a framework for OGM. The model comprises of three mechanisms, capture and rumination, functional avoidance and impaired executive control. These can independently, or in interaction, account for OGM. This systematic review aims to evaluate the existing research on the CaR-FA-X model, and trauma exposure studies specific to child and adolescent populations. The following databases were searched: "PsychInfo", "PsychArticles", "PubMed", "Web of Science", "Medline", "SCOPUS" and "Embase" for English-language, peer-reviewed papers with samples FA-X model was found for child and adolescent populations. Recommendations, proposals for future research and plausible explanations for the mixed findings are discussed.

Diets containing salmon fillet delay development of high blood pressure and hyperfusion damage in kidneys in obese Zucker fa/fa rats.

Science.gov (United States)

Vikøren, Linn A; Drotningsvik, Aslaug; Mwakimonga, Angela; Leh, Sabine; Mellgren, Gunnar; Gudbrandsen, Oddrun A

2018-04-01

Hypertension is the leading risk factor for cardiovascular and chronic renal diseases, affecting more than 1 billion people. Fish intake is inversely correlated with the prevalence of hypertension in several, but not all, studies, and intake of fish oil and fish proteins has shown promising potential to delay development of high blood pressure in rats. The effects of baked and raw salmon fillet intake on blood pressure and renal function were investigated in obese Zucker fa/fa rats, which spontaneously develop hypertension with proteinuria and renal failure. Rats were fed diets containing baked or raw salmon fillet in an amount corresponding to 25% of total protein from salmon and 75% of protein from casein, or casein as the sole protein source (control group) for 4 weeks. Results show lower blood pressure and lower urine concentrations of albumin and cystatin C (relative to creatinine) in salmon diet groups when compared to control group. Morphological examinations revealed less prominent hyperfusion damage in podocytes from rats fed diets containing baked or raw salmon when compared to control rats. In conclusion, diets containing baked or raw salmon fillet delayed the development of hypertension and protected against podocyte damage in obese Zucker fa/fa rats. Copyright © 2018 American Heart Association. Published by Elsevier Inc. All rights reserved.

Market Segmentation, Targeting, Dan Brand Positioning Dari Winston Premier Surabaya

OpenAIRE

Tania, Debby

2014-01-01

Sejak tahun 2012 mulai terasa bahwa bisnis properti mengalami kenaikan di Indonesia. Banyak masyarakat Indonesia berinvestasi pada properti karena dianggap aman dan menguntungkan. Sehingga muncul banyak produk properti baru di Indonesia. Perkembangan properti di Indonesia menjadi peluang besar bagi Agen Properti untuk dapat menjalankan bisnisnya. Winston Premier sebagai salah satu Agen properti di Surabaya Barat yang baru berdiri memerlukan strategi pemasaran yang tepat untuk digunakan guna b...

Oxide fuel fabrication technology development of the FaCT project (1). Overall review of fuel technology development of the FaCT project

International Nuclear Information System (INIS)

Abe, Tomoyuki; Namekawa, Takashi; Tanaka, Kenya

2011-01-01

The FaCT project is in progress in Japan for the commercialization of fast reactor cycle system. The development goal of the fuel in the FaCT project is a low-decontaminated TRU homo-recycling in a closed cycle and extension in average discharge burn-up to 150 GWd/t. Research and development on innovative technologies concerning the short process, remote maintenance and cooling system of automatic fuel production equipments, long life cladding material and control of oxygen potential have been conducted in phase I of the FaCT project. As the result of various test including 600 g batch MOX tests, it is concluded that the short process is available to fuel pellet fabrication of the FaCT project. Although cold mock-up tests on test model of some typical process equipments suggest possibilities of remote maintenance of automatic fuel fabrication equipment, it is concluded that it still needs further efforts to judge the operability of the completely remote fabrication for low-decontaminated TRU fuel. A cold mock-up test on fuel pin assembling equipment show that influence of decay heat of MA can be managed by cooling system. Irradiation tests in BOR-60 indicate that 9Cr-ODS possess the satisfactory in-reactor performance as the long life cladding material if homogeneity of alloy element is adequately controlled. Modification of cladding tube fabrication process to ensure homogeneity and further development of measures to control oxygen potential inside the fuel pin are necessary to reach the burn-up target of the FaCT project. (author)

Atmospheric histories and global emissions of the anthropogenic hydrofluorocarbons HFC-365mfc, HFC-245fa, HFC-227ea, and HFC-236fa

Science.gov (United States)

Vollmer, Martin K.; Miller, Benjamin R.; Rigby, Matthew; Reimann, Stefan; Mühle, Jens; Krummel, Paul B.; O'Doherty, Simon; Kim, Jooil; Rhee, Tae Siek; Weiss, Ray F.; Fraser, Paul J.; Simmonds, Peter G.; Salameh, Peter K.; Harth, Christina M.; Wang, Ray H. J.; Steele, L. Paul; Young, Dickon; Lunder, Chris R.; Hermansen, Ove; Ivy, Diane; Arnold, Tim; Schmidbauer, Norbert; Kim, Kyung-Ryul; Greally, Brian R.; Hill, Matthias; Leist, Michael; Wenger, Angelina; Prinn, Ronald G.

2011-04-01

We report on ground-based atmospheric measurements and emission estimates of the four anthropogenic hydrofluorocarbons (HFCs) HFC-365mfc (CH3CF2CH2CF3, 1,1,1,3,3-pentafluorobutane), HFC-245fa (CHF2CH2CF3, 1,1,1,3,3-pentafluoropropane), HFC-227ea (CF3CHFCF3, 1,1,1,2,3,3,3-heptafluoropropane), and HFC-236fa (CF3CH2CF3, 1,1,1,3,3,3-hexafluoropropane). In situ measurements are from the global monitoring sites of the Advanced Global Atmospheric Gases Experiment (AGAGE), the System for Observations of Halogenated Greenhouse Gases in Europe (SOGE), and Gosan (South Korea). We include the first halocarbon flask sample measurements from the Antarctic research stations King Sejong and Troll. We also present measurements of archived air samples from both hemispheres back to the 1970s. We use a two-dimensional atmospheric transport model to simulate global atmospheric abundances and to estimate global emissions. HFC-365mfc and HFC-245fa first appeared in the atmosphere only ˜1 decade ago; they have grown rapidly to globally averaged dry air mole fractions of 0.53 ppt (in parts per trillion, 10-12) and 1.1 ppt, respectively, by the end of 2010. In contrast, HFC-227ea first appeared in the global atmosphere in the 1980s and has since grown to ˜0.58 ppt. We report the first measurements of HFC-236fa in the atmosphere. This long-lived compound was present in the atmosphere at only 0.074 ppt in 2010. All four substances exhibit yearly growth rates of >8% yr-1 at the end of 2010. We find rapidly increasing emissions for the foam-blowing compounds HFC-365mfc and HFC-245fa starting in ˜2002. After peaking in 2006 (HFC-365mfc: 3.2 kt yr-1, HFC-245fa: 6.5 kt yr-1), emissions began to decline. Our results for these two compounds suggest that recent estimates from long-term projections (to the late 21st century) have strongly overestimated emissions for the early years of the projections (˜2005-2010). Global HFC-227ea and HFC-236fa emissions have grown to average values of 2.4 kt yr-1

40Ar-39Ar laser probe dating of individual clinopyroxene inclusions in Premier eclogitic diamonds

International Nuclear Information System (INIS)

Burgess, R.; Turner, G.; Laurenzi, M.; Harris, J.W.

1989-01-01

The ages of seven individual clinopyroxene inclusions in Premier diamonds of eclogitic association have been determined using the 40 Ar- 39 Ar dating technique. Syngenetic inclusions weighing between 10 and 130 μg were exposed on cleaved surfaces of the diamonds and analysed using a laser probe. The inclusion ages were found to be in the range 1111±35 to 1254±38 Ma with an average of 1185±94 Ma. The ages obtained are in good agreement with previous determinations made on aggregates of eclogitic inclusions from Premier diamonds and demonstrate the applicability of the laser probe to dating individual diamond inclusions. (orig.)

Whole exome sequencing reveals concomitant mutations of multiple FA genes in individual Fanconi anemia patients.

Science.gov (United States)

Chang, Lixian; Yuan, Weiping; Zeng, Huimin; Zhou, Quanquan; Wei, Wei; Zhou, Jianfeng; Li, Miaomiao; Wang, Xiaomin; Xu, Mingjiang; Yang, Fengchun; Yang, Yungui; Cheng, Tao; Zhu, Xiaofan

2014-05-15

Fanconi anemia (FA) is a rare inherited genetic syndrome with highly variable clinical manifestations. Fifteen genetic subtypes of FA have been identified. Traditional complementation tests for grouping studies have been used generally in FA patients and in stepwise methods to identify the FA type, which can result in incomplete genetic information from FA patients. We diagnosed five pediatric patients with FA based on clinical manifestations, and we performed exome sequencing of peripheral blood specimens from these patients and their family members. The related sequencing data were then analyzed by bioinformatics, and the FANC gene mutations identified by exome sequencing were confirmed by PCR re-sequencing. Homozygous and compound heterozygous mutations of FANC genes were identified in all of the patients. The FA subtypes of the patients included FANCA, FANCM and FANCD2. Interestingly, four FA patients harbored multiple mutations in at least two FA genes, and some of these mutations have not been previously reported. These patients' clinical manifestations were vastly different from each other, as were their treatment responses to androstanazol and prednisone. This finding suggests that heterozygous mutation(s) in FA genes could also have diverse biological and/or pathophysiological effects on FA patients or FA gene carriers. Interestingly, we were not able to identify de novo mutations in the genes implicated in DNA repair pathways when the sequencing data of patients were compared with those of their parents. Our results indicate that Chinese FA patients and carriers might have higher and more complex mutation rates in FANC genes than have been conventionally recognized. Testing of the fifteen FANC genes in FA patients and their family members should be a regular clinical practice to determine the optimal care for the individual patient, to counsel the family and to obtain a better understanding of FA pathophysiology.

Disruption of the FA/BRCA pathway in bladder cancer.

Science.gov (United States)

Neveling, K; Kalb, R; Florl, A R; Herterich, S; Friedl, R; Hoehn, H; Hader, C; Hartmann, F H; Nanda, I; Steinlein, C; Schmid, M; Tonnies, H; Hurst, C D; Knowles, M A; Hanenberg, H; Schulz, W A; Schindler, D

2007-01-01

Bladder carcinomas frequently show extensive deletions of chromosomes 9p and/or 9q, potentially including the loci of the Fanconi anemia (FA) genes FANCC and FANCG. FA is a rare recessive disease due to defects in anyone of 13 FANC genes manifesting with genetic instability and increased risk of neoplasia. FA cells are hypersensitive towards DNA crosslinking agents such as mitomycin C and cisplatin that are commonly employed in the chemotherapy of bladder cancers. These observations suggest the possibility of disruption of the FA/BRCA DNA repair pathway in bladder tumors. However, mutations in FANCC or FANCG could not be detected in any of 23 bladder carcinoma cell lines and ten surgical tumor specimens by LOH analysis or by FANCD2 immunoblotting assessing proficiency of the pathway. Only a single cell line, BFTC909, proved defective for FANCD2 monoubiquitination and was highly sensitive towards mitomycin C. This increased sensitivity was restored specifically by transfer of the FANCF gene. Sequencing of FANCF in BFTC909 failed to identify mutations, but methylation of cytosine residues in the FANCF promoter region was demonstrated by methylation-specific PCR, HpaII restriction and bisulfite DNA sequencing. Methylation-specific PCR uncovered only a single instance of FANCF promoter hypermethylation in surgical specimens of further 41 bladder carcinomas. These low proportions suggest that in contrast to other types of tumors silencing of FANCF is a rare event in bladder cancer and that an intact FA/BRCA pathway might be advantageous for tumor progression. Copyright (c) 2007 S. Karger AG, Basel.

40Ar/39Ar laser-probe dating of diamond inclusions from the Premier kimberlite

International Nuclear Information System (INIS)

Phillips, D.; Onstott, T.C.; Harris, J.W.; Strathclyde Univ., Glasgow

1989-01-01

Inclusions encapsulated by diamonds at the time of their formation provide a means for determining diamond crystallization ages and the chemistry of the surrounding upper mantle at that time. Sm-Nd studies of peridotitic inclusions, from Cretaceous-age kimberlites in southern Africa, suggest that the diamonds formed 3.3 Gyr ago. By contrast, eclogite-suite inclusions generally yield younger ages, sometimes approaching the time of kimberlite eruption. Here we report the results of 40 Ar/ 39 Ar laser-probe analyses of individual eclogitic clinopyroxene inclusions from Premier diamonds, which yield a mean age of 1,198±14 Myr. This age agrees well with Sm-Nd and 40 Ar/ 39 Ar analyses on similar Premier inclusions, and is indistinguishable from the inferred time of emplacement of the host kimberlite (1,150-1,230 Myr), which implies that diamond formation was essentially synchronous with kimberlite generation. The extrapolated non-radiogenic 40 Ar/ 36 Ar ratio of 334±102 is similar to the present-day atmospheric composition. This value is inconsistent with Sr and Nd isotopic signatures from Premier eclogite inclusions, which suggest a depleted mantle source ( 40 Ar/ 36 Ar>20,000). Pre-entrapment equilibration of the inclusions with an 36 Ar-rich fluid is the most probable explanation for the low non-radiogenic ( 40 Ar/ 36 Ar) composition. (author)

Evaluated experimental database on critical heat flux in WWER FA models

International Nuclear Information System (INIS)

Artamonov, S.; Sergeev, V.; Volkov, S.

2015-01-01

The paper presents the description of the evaluated experimental database on critical heat flux in WWER FA models of new designs. This database was developed on the basis of the experimental data obtained in the years of 2009-2012. In the course of its development, the database was reviewed in terms of completeness of the information about the experiments and its compliance with the requirements of Rostekhnadzor regulatory documents. The description of the experimental FA model characteristics and experimental conditions was specified. Besides, the experimental data were statistically processed with the aim to reject incorrect ones and the sets of experimental data on critical heat fluxes (CHF) were compared for different FA models. As a result, for the fi rst time, the evaluated database on CHF in FA models of new designs was developed, that was complemented with analysis functions, and its main purpose is to be used in the process of development, verification and upgrading of calculation techniques. The developed database incorporates the data of 4183 experimental conditions obtained in 53 WWER FA models of various designs. Keywords: WWER reactor, fuel assembly, CHF, evaluated experimental data, database, statistical analysis. (author)

RANKING THE SPECTATORS’ DIFFICULTIES IN PURCHASING ELECTRONIC TICKETS OF FOOTBALL PREMIER LEAGUE

Directory of Open Access Journals (Sweden)

Ahmad Narimani

2017-04-01

Full Text Available This study aimed to rank the spectators’ difficulties in buying electronic tickets of football premier league matches at Azadi stadium. The population consisted of all spectators of Esteghlal-Persepolis match in the fifteenth league at Azadi stadium (N= 100000. According to Morgan table and using simple random sampling method, 500 participants were selected as sample. A researcher-made questionnaire was used for collecting the data; its face validity was confirmed by 15 experts and performing a pilot study on 30 subjects, its Cronbach’s alpha was calculated to be 0.86. Using SPSS 22, the descriptive and inferential (including Friedman test statistics was applied for analyzing the data. The findings showed that there was a significant difference between rankings of difficulties in buying electronic tickets of Football premier league matches at Azadi Stadium. The difficulties were ranked as: problem in ticket systems, early selling out of electronic tickets, lack of confidence to electronic ticket sale, lack of skill to work with the internet, low speed of internet, and lack of access to the internet

Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1/BRCA2

Energy Technology Data Exchange (ETDEWEB)

Godthelp, Barbara C. [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands); Buul, Paul P.W. van [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands); Jaspers, Nicolaas G.J. [Department of Cell Biology and Genetics, Erasmus University, P.O. Box 1738, 3000 DR Rotterdam (Netherlands); Elghalbzouri-Maghrani, Elhaam [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands); Duijn-Goedhart, Annemarie van [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands); Arwert, Fre [Department of Clinical Genetics and Human Genetics, Free University Medical Center, Amsterdam (Netherlands); Joenje, Hans [Department of Clinical Genetics and Human Genetics, Free University Medical Center, Amsterdam (Netherlands); Zdzienicka, Malgorzata Z. [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands) and Department of Molecular Cell Genetics, Collegium Medicum, N.Copernicus University, Bydgoszcz (Poland)]. E-mail: M.Z.Zdzienicka@LUMC.nl

2006-10-10

Fanconi anemia (FA) is an inherited cancer-susceptibility disorder, characterized by genomic instability and hypersensitivity to DNA cross-linking agents. The discovery of biallelic BRCA2 mutations in the FA-D1 complementation group allows for the first time to study the characteristics of primary BRCA2-deficient human cells. FANCD1/BRCA2-deficient fibroblasts appeared hypersensitive to mitomycin C (MMC), slightly sensitive to methyl methane sulfonate (MMS), and like cells derived from other FA complementation groups, not sensitive to X-ray irradiation. However, unlike other FA cells, FA-D1 cells were slightly sensitive to UV irradiation. Despite the observed lack of X-ray sensitivity in cell survival, significant radioresistant DNA synthesis (RDS) was observed in the BRCA2-deficient fibroblasts but also in the FANCA-deficient fibroblasts, suggesting an impaired S-phase checkpoint. FA-D1/BRCA2 cells displayed greatly enhanced levels of spontaneous as well as MMC-induced chromosomal aberrations (Canada), similar to cells deficient in homologous recombination (HR) and non-D1 FA cells. In contrast to Brca2-deficient rodent cells, FA-D1/BRCA2 cells showed normal sister chromatid exchange (SCE) levels, both spontaneous as well as after MMC treatment. Hence, these data indicate that human cells with biallelic BRCA2 mutations display typical features of both FA- and HR-deficient cells, which suggests that FANCD1/BRCA2 is part of the integrated FA/BRCA DNA damage response pathway but also controls other functions outside the FA pathway.

Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1/BRCA2

International Nuclear Information System (INIS)

Godthelp, Barbara C.; Buul, Paul P.W. van; Jaspers, Nicolaas G.J.; Elghalbzouri-Maghrani, Elhaam; Duijn-Goedhart, Annemarie van; Arwert, Fre; Joenje, Hans; Zdzienicka, Malgorzata Z.

2006-01-01

Fanconi anemia (FA) is an inherited cancer-susceptibility disorder, characterized by genomic instability and hypersensitivity to DNA cross-linking agents. The discovery of biallelic BRCA2 mutations in the FA-D1 complementation group allows for the first time to study the characteristics of primary BRCA2-deficient human cells. FANCD1/BRCA2-deficient fibroblasts appeared hypersensitive to mitomycin C (MMC), slightly sensitive to methyl methane sulfonate (MMS), and like cells derived from other FA complementation groups, not sensitive to X-ray irradiation. However, unlike other FA cells, FA-D1 cells were slightly sensitive to UV irradiation. Despite the observed lack of X-ray sensitivity in cell survival, significant radioresistant DNA synthesis (RDS) was observed in the BRCA2-deficient fibroblasts but also in the FANCA-deficient fibroblasts, suggesting an impaired S-phase checkpoint. FA-D1/BRCA2 cells displayed greatly enhanced levels of spontaneous as well as MMC-induced chromosomal aberrations (Canada), similar to cells deficient in homologous recombination (HR) and non-D1 FA cells. In contrast to Brca2-deficient rodent cells, FA-D1/BRCA2 cells showed normal sister chromatid exchange (SCE) levels, both spontaneous as well as after MMC treatment. Hence, these data indicate that human cells with biallelic BRCA2 mutations display typical features of both FA- and HR-deficient cells, which suggests that FANCD1/BRCA2 is part of the integrated FA/BRCA DNA damage response pathway but also controls other functions outside the FA pathway

Effects of baked and raw salmon fillet on lipids and n-3 PUFAs in serum and tissues in Zucker fa/fa rats

OpenAIRE

Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Bergseth, Marthe Tønder; Mjøs, Svein Are; Mola, Nazanin; Leh, Sabine Maria; Mellgren, Gunnar; Gudbrandsen, Oddrun Anita

2017-01-01

ABSTRACT Knowledge of the health impact of consuming heat-treated versus raw fish fillet is limited. To investigate effects of baked or raw salmon fillet intake on lipids and n-3 PUFAs in serum and tissues, obese Zucker fa/fa rats were fed diets containing 25% of protein from baked or raw salmon fillet and 75% of protein from casein, or casein as the sole protein source (control group) for four weeks. Salmon diets had similar composition of amino and fatty acids. Growth and energy intake were...

Un premier service mobile en Égypte qui relie les petits exploitants ...

International Development Research Centre (IDRC) Digital Library (Canada)

Un premier service mobile en Égypte qui relie les petits exploitants aux acheteurs. Un homme qui parle sur un téléphone mobile. Les petits exploitants agricoles dominent l'agriculture égyptienne, mais leur manque de connaissances en matière de commercialisation et de compétences techniques, ainsi qu'une mauvaise ...

Does Fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials?

DEFF Research Database (Denmark)

Jensen, Charlotte Floridon; Jensen, Charlotte Harken; Thorsen, Poul

2000-01-01

Fetal antigen 1 (FA1) is a circulating EGF multidomain glycoprotein. FA1 and its membrane-associated precursor is defined by the mRNAs referred to as delta-like (dlk), preadipocyte factor 1 (pref-1) or zona glomerulosa-specific factor (ZOG). Using a polyclonal antibody recognising both forms......, the localisation of FA1/dlk was analysed in embryonic and fetal tissues between week 5 to 25 of gestation and related to germinal origin and development. FA1 was observed in endodermally derived hepatocytes, glandular cells of the pancreas anlage, and in respiratory epithelial cells. FA1 was also present...... in mesodermally derived cells of the renal proximal tubules, adrenal cortex, Leydig and Hilus cells of the testes and ovaries, fetal chondroblasts, and skeletal myotubes. Ectodermally derived neuro- and adenohypophysial cells, cells in the floor of the 3rd ventricle and plexus choroideus were also FA1 positive...

FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2.

Directory of Open Access Journals (Sweden)

Maria Castella

2015-10-01

Full Text Available The Fanconi anemia (FA-BRCA pathway mediates repair of DNA interstrand crosslinks. The FA core complex, a multi-subunit ubiquitin ligase, participates in the detection of DNA lesions and monoubiquitinates two downstream FA proteins, FANCD2 and FANCI (or the ID complex. However, the regulation of the FA core complex itself is poorly understood. Here we show that the FA core complex proteins are recruited to sites of DNA damage and form nuclear foci in S and G2 phases of the cell cycle. ATR kinase activity, an intact FA core complex and FANCM-FAAP24 were crucial for this recruitment. Surprisingly, FANCI, but not its partner FANCD2, was needed for efficient FA core complex foci formation. Monoubiquitination or ATR-dependent phosphorylation of FANCI were not required for the FA core complex recruitment, but FANCI deubiquitination by USP1 was. Additionally, BRCA1 was required for efficient FA core complex foci formation. These findings indicate that FANCI functions upstream of FA core complex recruitment independently of FANCD2, and alter the current view of the FA-BRCA pathway.

Cloning and expression analysis of FaPR-1 gene in strawberry

Science.gov (United States)

Mo, Fan; Luo, Ya; Ge, Cong; Mo, Qin; Ling, Yajie; Luo, Shu; Tang, Haoru

2018-04-01

The FaPR-1 gene was cloned by RT-PCR from `Benihoppe' strawberry and its bioinformatics analysis was conducted. The results showed that the open reading frame was 483 bp encoding encoding l60 amino acids which protein molecular weight and theoretical isoelectricity were 17854.17 and 8.72 respectively. Subcellular localization prediction shows that this gene is located extracellularly. By comparing strawberry FaPR-l and other plant Pathogenesis-related protein, homology and phylogenetic tree construction showed that the homology with grapes, peach is relatively close. In the treatments of ABA, sucrose and the mixture of the two, the expression of FaPR-1 in strawberry fruit were significantly increased.

Status of JSFR development in phase I FaCT project

International Nuclear Information System (INIS)

Aoto, Kazumi; Chikazawa, Yoshitaka; Kotake, Shoji; Ito, Takaya

2011-01-01

The Fast Reactor Cycle Technology Development (FaCT) project is pursuing commercialization of fast reactor cycle system around 2050 under cooperation of MEXT (Ministry of Education, Culture, Sports, Science and Technology), METI (Ministry of Economy, Trade and Industry), utilities, venders and JAEA (Japan Atomic Energy Agency). As results of the FaCT Phase I, the key technologies for Japan Sodium-cooled Fast Reactor (JSFR) has been evaluated. (author)

Les animateurs TICE du premier degré, quelle professionnalité ?

OpenAIRE

Villemonteix , François

2007-01-01

International audience; Les animateurs TICE du premier degré, quelle professionnalité ? Congrès international AREF 2007 (Actualité de la Recherche en Education et en Formation) François VILLEMONTEIX Doctorant Laboratoire EDA (Education et apprentissages) Université Paris 5 – La Sorbonne franç RÉSUMÉ. Dans le but de favoriser le développement d'usages instrumentés dans les classes de l'école primaire française, l'institution éducative a depuis les années 80 at...

Altered Rhythms. Urban façades in post-war Milan

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Magda Mària Serrano

2017-10-01

Full Text Available Urban façades are the outward manifestation of the character of a city, and are composed of elements that respond to rhythmic sequences in consonance with the internal order of the rooms behind them. In post-war Milan, façades were used as a field of experimentation by a group of architects, some of whom were also artists and designers, who saw themselves and can be seen as ambassadors for the future modernity of a city devastated by war. This article explains how the urban façades of Milan, based as they were on the themes drawn from the Italian compositional tradition, offer a wide variety of elements, figures and rhythms, altering and transgressing the compositional canons through the use of mechanisms that in some cases are closer to painting or sculpture than to architecture.

JPRS Report Science & Technology Japan Future Prospects of FA-From FA to IMS

Science.gov (United States)

1989-12-04

of FA Investment (Large Companies) a) m d) m 5000fI~ljl|S 1 m± ¥-1$ 500~1000t| 300~500(f 1000~3000ft i) £ÜÜ 0i!§£3^ SWOT # H^fc3S j) k) 1...is a method conceived by Toyota Motors, now widely understood throughout the world. Such information as the production volume, time, method and...T. Suzuki Toyota Motor Corp. Y. Tatsue AIST, Mechanical Engineering Laboratory K. Togino Komatsu Ltd. H. Torii Nihon Keizai Shimbun Editorial

Estrogen Inhibits Dlk1/FA1 Production: A Potential Mechanism for Estrogen Effects on Bone Turnover

Science.gov (United States)

Abdallah, B. M.; Bay-Jensen, A.; Srinivasan, B.; Tabassi, N. C.; Garnero, P.; Delaissé, J.; Khosla, S.; Kassem, M.

2011-01-01

We have recently identified Dlk1/FA1 (Delta-like 1/FA1) as a novel regulator of bone mass that functions to mediate bone loss, under estrogen deficiency, in mice. In this report, we investigated the effects of estrogen (E)-deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (s-CTx and s-osteocalcin), were measured in two cohorts: a group of pre- and postmenopausal women (n=100) and a group of postmenopausal women, where half had received estrogen replacement therapy (ERT) (n=166). s-Dlk1/FA1, and s-CTX were elevated in postmenopausal E-deficient compared to premenopausal E-replete women (both; P<0.001). s-Dlk1/FA1 was correlated with s-CTX (r=0.30, P<0.01). ERT, in postmenopausal women, decreased s-Dlk1/FA1, as well as s-CTX and s-osteoclacin (all; P<0.0001). Changes in s-Dlk1 were significantly correlated with those observed in s-CTx (r=0.18, P<0.05) and s-osteocalcin (r=0.28, P<0.001). In conclusion, s-Dlk1/FA1 is influenced by E-deficiency and is correlated with bone turnover. Increased levels of s-Dlk1/FA1 in post-menopausal women may be a mechanism mediating the effects estrogen deficiency on bone turnover. PMID:21681814

The provision of medical care in English professional football: An update.

Science.gov (United States)

Malcolm, Dominic; Scott-Bell, Andrea; Waddington, Ivan

2017-12-01

To compare the current methods of appointment, qualifications and occupational experience of club doctors and physiotherapists in English professional football with (i) those outlined in a study published in 1999, and (ii) Football Association (FA) medical regulations. Qualitative. Postal questionnaire survey of (head) doctors and physiotherapists at each of the clubs in the English Premiership, Championship and Football Leagues 1 and 2. Response rates of 35.8% and 45.6% respectively were obtained. The majority of football club doctors are GPs who have sports medicine qualifications and relevant occupational experience. Time commitments vary from full time to a few hours per week. Most are appointed through personal contacts rather than job advertisements and/or interview. Almost all football clubs have a chartered physiotherapist, many of whom have a postgraduate qualification. They work full time and long hours. Most are appointed through personal contacts rather than job advertisements. They are frequently interviewed but not always by someone qualified to judge their professional expertise. Football club medical provision has become more extensive and increasingly professional over the last 10-20years, with better qualified, more career-oriented and more formally contracted staff. It is likely that clinical autonomy has subsequently increased. However recruitment procedures still need to be improved, especially in relation to advertising vacancies, interviewing candidates, and including medical personnel on interview panels. In two aspects clubs appear not to be compliant with current FA medical regulations. Copyright © 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

Application and properties of pure lime façades - case study

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Violeta Bokan Bosiljkov

2008-01-01

Full Text Available The paper presents experiences obtained during application and testing of different pure lime façades that could be successfully used in restoration of historical buildings in Slovenia. The lime façade consists of a rendering layer (rough mortar, a finishing layer (fine mortar and a protective layer of lime wash. For the design of the mortars different industrially and traditionally produced limes were chosen, based on the results of preliminary studies of the authors and experiences of a small enterprise (SE involved in the study. The façade layers were applied to the most problematic northern wall of the historic chapel made from rubble masonry. The chapel belongs to the castle Crnelo, built at the end of the 17th century in the village Turnše, not far from Ljubljana, the capital of Slovenia. The façade layers were made by skilled workers of SE, with about one year time difference between application of rendering and finishing layers, and with a protective layer of coloured lime wash applied to one to three day old finishing layers. On the rendering layers, visual inspection, water absorption tests and determination of carbonation depth were carried out before subsequent finishing layers were applied. The same on-site tests were carried out also on finished façade layers. So far, parallel to the on-site tests, compressive and water absorption tests on prisms prepared from rough mortars were carried out in laboratory.

The cleaner, the greener? Product sustainability assessment of the biomimetic façade paint Lotusan® in comparison to the conventional façade paint Jumbosil®

Directory of Open Access Journals (Sweden)

Florian Antony

2016-12-01

Full Text Available Background: The debate on the question whether biomimetics has a specific potential to contribute to sustainability is discussed among scientists, business leaders, politicians and those responsible for project funding. The objective of this paper is to contribute to this controversial debate by presenting the sustainability assessment of one of the most well-known and most successful biomimetic products: the façade paint Lotusan®.Results: As a first step it has been examined and verified that the façade paint Lotusan® is correctly defined as a biomimetic product. Secondly, Lotusan® has been assessed and compared to a conventional façade paint within the course of a detailed product sustainability assessment (PROSA. For purposes of comparison, the façade paint Jumbosil® was chosen as reference for a conventional paint available on the market. The benefit analysis showed that both paints fulfil equally well the requirements of functional utility. With respect to the symbolic utility, Lotusan® has a particular added aesthetic value by the preservation of the optical quality over the life cycle. Within the social analysis no substantial differences between the two paints could be found regarding the handling and disposal of the final products. Regarding the life-cycle cost, Lotusan® is the more expensive product. However, the higher investment cost for a Lotusan®-based façade painting are more than compensated by the longer life time, resulting in both reduced overall material demand and lower labour cost. In terms of the life-cycle impact assessment, it can be ascertained that substantial differences between the paints arise from the respective service life, which are presented in terms of four scenario analyses.Conclusion: In summary, the biomimetic façade paint Lotusan® has been identified as a cost-effective and at the same time resource-saving product. Based on the underlying data and assumptions it could be demonstrated that

checkCIF/PLATON report Datablock: fa289

Indian Academy of Sciences (India)

THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors found. CIF dictionary Interpreting this report. Datablock: fa289. Bond precision:.

AppFA: A Novel Approach to Detect Malicious Android Applications on the Network

Directory of Open Access Journals (Sweden)

Gaofeng He

2018-01-01

Full Text Available We propose AppFA, an Application Flow Analysis approach, to detect malicious Android applications (simply apps on the network. Unlike most of the existing work, AppFA does not need to install programs on mobile devices or modify mobile operating systems to extract detection features. Besides, it is able to handle encrypted network traffic. Specifically, we propose a constrained clustering algorithm to classify apps network traffic, and use Kernel Principal Component Analysis to build their network behavior profiles. After that, peer group analysis is explored to detect malicious apps by comparing apps’ network behavior profiles with the historical data and the profiles of their selected peer groups. These steps can be repeated every several minutes to meet the requirement of online detection. We have implemented AppFA and tested it with a public dataset. The experimental results show that AppFA can cluster apps network traffic efficiently and detect malicious Android apps with high accuracy and low false positive rate. We have also tested the performance of AppFA from the computational time standpoint.

[Sõltumatu Tantsu Ühenduse poolt korraldatud sarjast "Premiere"] / Evelin Lagle ; küsinud Tambet Kaugema

Index Scriptorium Estoniae

Lagle, Evelin, 1986-

2012-01-01

Uutele koreograafidele pühendatud sarja "Premiere" programmis osalevad tantsulavastustega neli tantsukunstnikku Eestist - Tallinna Ülikooli lõpetanud Svetlana Grigorjeva, Turu Kunstiakadeemia lõpetanud Kaisa Selde, Viljandi Kultuuriakadeemia lõpetanud Kristina-Maria Heinsalu ja Tallinna Ülikooli lõpetanud Christin Lunts

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT - PHYSICAL REMOVAL OF MICROBIAL CONTAMINATION AGENTS IN DRINKING WATER, WATTS P{REMIER ULTRA 5 REVERSE OSMOSIS DRINKING WATER TREATMENT SYSTEM (POU)

Science.gov (United States)

The Watts Premier Ultra 5 system was tested for removal of bacteria and viruses at NSF International's Laboratory. Watts Premier submitted ten units, which were split into two groups of five. One group received 25 days of conditioning prior to challenge testing, while the secon...

Efectos sobre el metabolismo lipoproteico y estrés oxidativo en ratas zucker fa/fa de cárnicos enriquecidos con glucomanano y espirulina

OpenAIRE

González Torres, Laura

2016-01-01

Esta memoria doctoral versa sobre los estudios que se realizaron para evaluar los efectos de reestructurados cárnicos (RP) enriquecidos con glucomanano y espirulina sobre crecimiento, tamaño y estructura de órganos, glucemia, insulinemia, resistencia a la insulina, metabolismo lipoproteico y estrés oxidativo en un modelo de síndrome metabólico como es la rata Zucker fa/fa. Para ello se diseñaron diferentes dietas hipersaturadas, añadidas o no con agente hipercolesterolemiante, conteniendo 15%...

Plan Exportador FA. INTI.

OpenAIRE

Herrera Arias, Francisco

2009-01-01

El desarrollo del presente trabajo de grado, constituye un trabajo en equipo entre la Secretaria de Desarrollo Económico de la Alcaldía Mayor de Bogotá D.C., el CIDEM de la Universidad del Rosario y Maloka. La metodología aplicada del CIDEM a la empresa FA. INTI. se ha aplicado a mas de 1000 PYMES colombianas y ha sido coordinada por Francisco Herrera Arias y dirigida por la Dr. Luz Sofía Méndez y un equipo profesional de consultores. El plan exportador cuenta con información general de la em...

New methods for testing fire resistance of wood façade systems

Directory of Open Access Journals (Sweden)

Mårtensson August

2016-01-01

Full Text Available Arson in schools has been a huge problem in Sweden over the last fifteen years. The average amount of school arsons between 2000 and 2014 was 285 cases each year which corresponds to 50% of the total amount of reported fires in school buildings. This is a well-known problem and a lot of research has been done in this area. Investigations has been done about fire and heat detection systems, different technical factors significance in fire scenarios and how to prevent adolescents from starting fires. Another part of the problem that partly been investigated is how the schools are constructed. Roughly 50% of the arsons are outside of the school building. In Sweden one and two storey buildings are allowed to be built with wooden façades in accordance with the building code, which is one of the reasons many schools are built with wooden façade systems. The most critical part in a wood façade system from a fire safety perspective is concluded to be the eaves because of how they usually are built to let air pass through. Even though a wood façade isn't as well resistant to fire compared to a concrete façade, three versions of new test methods for combustible façades have been developed to make it possible to make sure in advance that a construction is resistant enough. The new test methods are focused on specific details and parts of a façade system to provide a more informative and useful result compared to SP Fire 105. Observations and measurements of flame spread and temperature changes in the eave, over the window joints and in the air gap are made. With these parameters in consideration criteria's has been chosen for a critical temperature of 280 ∘C at a critical time of 20 minutes.

ABOUT THE SMART SPORTS DEVELOPMENT. EVIDENCE FROM THE UK PREMIERE LEAGUE

Directory of Open Access Journals (Sweden)

Vlad Ionut Dumitrache

2016-11-01

Full Text Available Smart economy implies the development of key factors like global economy growth, competition, economic progress, economic prosperity, innovation. In the European top-level football, like the case of the British Premier League, financial indicators have demonstrated that the factors that define smart economy can be identified. The new rules of the financial fair-play policies and the ever growing revenues for television rights have created a new market in sports economy, one that identifies itself with the criteria identifies in studies regarding smart economy. This paper comparatively examines the determinants of four indicators of the football team quality in the British Premier League, in order to find out whether a common set of potential determinants could be effective in improving all four indicators of quality, without worsening any of them. This allows finding what measures undertaken at the level of football teams could raise the football team quality. Considering the subjective and multidimensional nature of the football team quality, we first propose four indicators that might be appropriate to define this latent summative measure. Then we select a number of four potentially common determinants of the football team quality, and finally discuss the empirical results, based on panel generalized least squares regression models. The television broadcasting rights are found to be the most important determinant of the football team quality.

Application Of FA Sensor 2

International Nuclear Information System (INIS)

Park, Seon Ho

1993-03-01

This book introduces FA sensor from basic to making system, which includes light sensor like photo diode and photo transistor, photo electricity sensor, CCD type image sensor, MOS type image sensor, color sensor, cds cell, and optical fiber scope. It also deals with direct election position sensor such as proximity switch, differential motion, linear scale of photo electricity type, and magnet scale, rotary sensor with summary of rotary encoder, rotary encoder types and applications, flow sensor, and sensing technology.

Physical interaction between the strawberry allergen Fra a 1 and an associated partner FaAP: Interaction of Fra a 1 proteins and FaAP.

Science.gov (United States)

Franz-Oberdorf, Katrin; Langer, Andreas; Strasser, Ralf; Isono, Erika; Ranftl, Quirin L; Wunschel, Christian; Schwab, Wilfried

2017-10-01

The strawberry fruit allergens Fra a 1.01E, Fra a 1.02 and Fra a 1.03 belong to the group of pathogenesis-related 10 (PR-10) proteins and are homologs of the major birch pollen Bet v 1 and apple allergen Mal d 1. Bet v 1 related proteins are the most extensively studied allergens but their physiological function in planta remains elusive. Since Mal d 1-Associated Protein has been previously identified as interaction partner of Mal d 1 we studied the binding of the orthologous Fra a 1-Associated Protein (FaAP) to Fra a 1.01E/1.02/1.03. As the C-terminal sequence of FaAP showed strong auto-activation activity in yeast 2-hybrid analysis a novel time resolved DNA-switching system was successfully applied. Fra a 1.01E, Fra a 1.02, and Fra a 1.03 bind to FaAP with K D of 4.5 ± 1.1, 15 ± 3, and 11 ± 2 nM, respectively. Fra a 1.01E forms a dimer, whereas Fra a 1.02 and Fra a 1.03 bind as monomer. The results imply that PR-10 proteins might be integrated into a protein-interaction network and FaAP binding appears to be essential for the physiological function of the Fra a 1 proteins. © 2017 Wiley Periodicals, Inc.

Analisis Kualitas Pelayanan terhadap Kepuasan Konsumen Jasa Hotel Santika Premiere Semarang

OpenAIRE

Dewangga, Nandy; Hidayat, Wahyu; Widiartanto, Widiartanto

2014-01-01

The competition of global business today focusing on consumers is a strategic choice in business world in order to survive. For example, the tight competition of business in the company of hotel services is by improving the service quality to consumers. The problems in this research were the decreasing number of hotel service users and the increasing number of consumer complaint as the service users of Santika Premiere Hotel in Semarang from year to year. The aims of this research were to ide...

checkCIF/PLATON report Datablock: fa083

Indian Academy of Sciences (India)

checkCIF/PLATON report. Structure factors have been supplied for datablock(s) fa083. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors ...

Measurement of FA and VitB12 in serum by TRFIA and its clinical application

International Nuclear Information System (INIS)

Zhou Jinhong; Wang Huimin

2006-01-01

To investigate the correlation between diseases and the quantity of folic acid(FA) and vitamine B 12 (VitB 12 ) in serum, the quantity of FA and VitB 12 in serum was measured by TR- FIA. The results showed that the levels of FA and VitB 12 in 68 controlled subjects were 20.13±5.72 nmol/L and 240.45±58.23 pmol/L respectively. The levels of FA and VitB 12 in 6 patients with megaloblastic anemia, 26 with medium-terminal gestation femineity, 7 with liver cirrhosis, 10 with gastric ulcerand 31 with cerebral infarction were significant lower than those in the control group. The level of FA in 24 with malignant hematopathy and 57 with malignant tumor was significantly lower but VitB 12 between the 31 patients with iron deficiency anemia and 12 with CAA and the control group. The amount of the FA in 9 patients with chronic atrophic gastritis and 42 blood donors were lower than that in the control. The determination of FA and VitB 12 levels may be quite significant in the diagnosis, therapy and prognosis of diseases. Laboratories should establish the reference values which fit the locals specifically. (authors)

Spread of smoke and heat along narrow air cavity in double-skin façade fires

Directory of Open Access Journals (Sweden)

Chow Lun Cheuk

2014-01-01

Full Text Available A scenario on double-skin façade fire was identified earlier for hazard assessment. A flashover room fire occurred next to the façade, broke the interior glass pane and spread to the façade cavity. As observed in experiments, hot gas moved up as a vertical channel flow for narrow façade cavity. Heat and smoke spread along the narrow air cavity of a double-skin façade will be studied in this paper. A simple mathematical model is developed from basic heat transfer theory for studying the vertical air temperature profiles of the hot gas flowing along the cavity. Assuming one-dimensional flow for hot gas moving up the façade cavity, conservation equations on mass and enthalpy were solved. Experimental results on two double-skin façade rigs of height 6 m and 15 m with narrow cavity depth were used to justify the results. A total of 11 tests were carried out. Correlation expressions between cavity air temperature and the height above ceiling of the fire room were derived.

VVER-440 fuel cycles possibilities using modified FA design

International Nuclear Information System (INIS)

Mikolas, P.; Svarny, J.; Razym, V.; Dostal, M.; Jenik, J.; Krupar, P.

2009-01-01

A nearly equilibrium five-year cycle has been achieved at Dukovany NPP over the last years. This means that working fuel assemblies (WFA) with an average enrichment of 4.25 w% (control assemblies (CA) with an average enrichment of 3.82 w%) are normally loaded and reloaded for five years. Operation at uprated thermal power (105% of the original one, increase from 1375 MW t to 1444 MW t ) is being prepared by use of WFA with an average enrichment of 4.38 w% (CA with an average enrichment of 4.25 w%). With the aim of fuel cycle economy improvement, the fuel residence time in the core has to be prolonged up to six years with one cycle duration time up to 18 months and preserving loadings with very low leakage. In order to achieve this goal, at least neutron-physical characteristics of FA must be improved and such changes should be evaluated from other viewpoints. Some particular changes have already been analyzed earlier. Designs of new fuel assemblies with higher (and in the central part of a FA the highest possible, i.e. 4.95 w%) enrichment with preserving low pin power non-uniformity are described in the presented paper. An FA with an average enrichment of 4.66 w% (lower than originally evaluated) containing six fuel pins with 3.35 w% Gd 2 O 3 content was selected in the end. Fuel pins have bigger pellet diameter, bigger pin pitch and thinner FA shroud. A newly designed FA was evaluated from the viewpoint of physics (pin power non-uniformity, criticality of fuel at transport and storage and determination of basic quantities for spent fuel storage purposes by ORIGEN code), thermo-hydraulics (comparison of subchannel output temperatures and the departure from nucleate boiling ratio - DNBR) and mechanical properties. The purpose of this study was to simulate an FA subject to the loads during its six- year lifetime whereas normal working conditions were taken into account. There are presented two models with different shroud thickness undergoing these analyses. Both

Energy performance of a ventilated façade by simulation with experimental validation

International Nuclear Information System (INIS)

Aparicio-Fernández, Carolina; Vivancos, José-Luis; Ferrer-Gisbert, Pablo; Royo-Pastor, Rafael

2014-01-01

A model for a building with ventilated façade was created using the software tool TRNSYS, version 17, and airflow parameters were simulated using TRNFlow. The results obtained with the model are compared and validated with experimental data. The temperature distribution along the air cavity was analysed and a chimney effect was observed, which produced the highest temperature gradient on the first floor. The heat flux of the external wall was analysed, and greater temperatures were observed on the external layer and inside the cavity. The model allows to calculate the energy demand of the building façade proposing and evaluating passive strategies. The corresponding office building for computer laboratories located in Valencia (Spain), was monitored for a year. The thermal behaviour of the floating external sheet was analysed using an electronic panel designed for the reading and storage of data. A feasibility study of the recovery of hot air inside the façade into the building was performed. The results obtained showed a lower heating demand when hot air is introduced inside the building, increasing the efficiency of heat recovery equipment. - Highlights: •An existing office building was monitored for a year. •A model of a ventilated façade by TRNSYS simulation tool was validated. •Air flow parameters inside the ventilated façade were identified. •Recovery of the hot air inside the façade for input into the building was studied

The cathepsin B inhibitor, z-FA-CMK is toxic and readily induced cell death in human T lymphocytes

Energy Technology Data Exchange (ETDEWEB)

Liow, K.Y.; Chow, S.C., E-mail: chow.sek.chuen@monash.edu

2013-11-01

The cathepsin B inhibitor, benzyloxycarbonyl-phenylalanine-alanine-chloromethylketone (z-FA-CMK) was found to be toxic and readily induced cell death in the human T cell line, Jurkat, whereas two other analogs benzyloxycarbonyl-phenylalanine-alanine-fluoromethylketone (z-FA-FMK) and benzyloxycarbonyl-phenylalanine-alanine-diazomethylketone (z-FA-DMK) were not toxic. The toxicity of z-FA-CMK requires not only the CMK group, but also the presence of alanine in the P1 position and the benzyloxycarbonyl group at the N-terminal. Dose–response studies showed that lower concentrations of z-FA-CMK induced apoptosis in Jurkat T cells whereas higher concentrations induced necrosis. In z-FA-CMK-induced apoptosis, both initiator caspases (-8 and -9) and effector caspases (-3, -6 and -7) were processed to their respective subunits in Jurkat T cells. However, only the pro-form of the initiator caspases were reduced in z-FA-CMK-induced necrosis and no respective subunits were apparent. The caspase inihibitor benzyloxycarbonyl-valine-alanine-aspartic acid-(O-methyl)-fluoromehylketone (z-VAD-FMK) inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentration of z-FA-CMK but has no effect on z-FA-CMK-induced necrosis and the loss of initiator caspases. This suggests that the loss of initiator caspases in Jurkat T cells during z-FA-CMK-induced necrosis is not a caspase-dependent process. Taken together, we have demonstrated that z-FA-CMK is toxic to Jurkat T cells and induces apoptosis at low concentrations, while at higher concentrations the cells die of necrosis. - Highlights: • z-FA-CMK is toxic and induce cell death in the human T cells. • z-FA-CMK toxicity requires the CMK group, alanine and the benzyloxycarbonyl group. • z-FA-CMK induced apoptosis at low concentration and necrosis at high concentration.

The cathepsin B inhibitor, z-FA-CMK is toxic and readily induced cell death in human T lymphocytes

International Nuclear Information System (INIS)

Liow, K.Y.; Chow, S.C.

2013-01-01

The cathepsin B inhibitor, benzyloxycarbonyl-phenylalanine-alanine-chloromethylketone (z-FA-CMK) was found to be toxic and readily induced cell death in the human T cell line, Jurkat, whereas two other analogs benzyloxycarbonyl-phenylalanine-alanine-fluoromethylketone (z-FA-FMK) and benzyloxycarbonyl-phenylalanine-alanine-diazomethylketone (z-FA-DMK) were not toxic. The toxicity of z-FA-CMK requires not only the CMK group, but also the presence of alanine in the P1 position and the benzyloxycarbonyl group at the N-terminal. Dose–response studies showed that lower concentrations of z-FA-CMK induced apoptosis in Jurkat T cells whereas higher concentrations induced necrosis. In z-FA-CMK-induced apoptosis, both initiator caspases (-8 and -9) and effector caspases (-3, -6 and -7) were processed to their respective subunits in Jurkat T cells. However, only the pro-form of the initiator caspases were reduced in z-FA-CMK-induced necrosis and no respective subunits were apparent. The caspase inihibitor benzyloxycarbonyl-valine-alanine-aspartic acid-(O-methyl)-fluoromehylketone (z-VAD-FMK) inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentration of z-FA-CMK but has no effect on z-FA-CMK-induced necrosis and the loss of initiator caspases. This suggests that the loss of initiator caspases in Jurkat T cells during z-FA-CMK-induced necrosis is not a caspase-dependent process. Taken together, we have demonstrated that z-FA-CMK is toxic to Jurkat T cells and induces apoptosis at low concentrations, while at higher concentrations the cells die of necrosis. - Highlights: • z-FA-CMK is toxic and induce cell death in the human T cells. • z-FA-CMK toxicity requires the CMK group, alanine and the benzyloxycarbonyl group. • z-FA-CMK induced apoptosis at low concentration and necrosis at high concentration

Architectural Kansei of ‘Wall’ in The Façade Design by Le Corbusier

Science.gov (United States)

Sendai, Shoichiro

The purpose of this paper is to discuss the modern architect Le Corbusier's architectural Kansei (sensibility) on wall in site environment through the analysis of his façade design, using Œuvres complètes (1910-1965, 8 vols., Les éditions d'architecture, Artemis, Zurich) and Le Corbusier Archives (1982-1984, 32 vols., Garland Publishing, Inc. and Fondation Le Corbusier, New York, London, Paris). At first, I arrange five façade types, according to the explanation by Le Corbusier ; ‘fenêtre en longueur (strip window)’, ‘pan de verre (glass wall)’, ‘brise-soleil (sun-breaker)’, ‘loggia’ and ‘claustra’. Through the analysis of the relationship between these types and the design process of each building, we find that Le Corbusier's façade design includes the affirmation and the negation of the ‘wall’ at the same time. In fact, the nature of façade modification during design process is divers: increase in transparency, decrease in transparency and spatialization of façade. That means, Le Corbusier studied the environmental condition by these façade types, and tried to realize the phenomenal openness. This trial bases on the function of architectural Kansei as correspondence between body and environment beyond the physical design.

Dynamic behavior of reactive aluminum nanoparticle-fluorinated acrylic (AlFA) polymer composites

Science.gov (United States)

Crouse, Christopher A.; White, Brad; Spowart, Jonathan E.

2011-06-01

The dynamic behavior of aluminum nanoparticle-fluorinated acrylic (AlFA) composite materials has been explored under high strain rates. Cylindrical pellets of the AlFA composite materials were mounted onto copper sabots and impacted against a rigid anvil at velocities between 100 and 400 m/s utilizing a Taylor gas gun apparatus to achieve strain rates on the order of 104 /s. A framing camera was used to record the compaction and reaction events that occurred upon contact of the pellet with the anvil. Under both open air and vacuum environments the AlFA composites demonstrated high reactivity suggesting that the particles are primarily reacting with the fluorinated matrix. We hypothesize, based upon the compaction history of these materials, that reaction is initiated when the oxide shells on the aluminum nanoparticles are broken due an interparticle contact deformation process. We have investigated this hypothesis through altering the particle loading in the AlFA composites as well as impact velocities. This data and the corresponding trends will be presented in detail.

Field-Evolved Mode 1 Resistance of the Fall Armyworm to Transgenic Cry1Fa-Expressing Corn Associated with Reduced Cry1Fa Toxin Binding and Midgut Alkaline Phosphatase Expression

Science.gov (United States)

Jakka, Siva R. K.; Gong, Liang; Hasler, James; Banerjee, Rahul; Sheets, Joel J.; Narva, Kenneth; Blanco, Carlos A.

2015-01-01

Insecticidal protein genes from the bacterium Bacillus thuringiensis (Bt) are expressed by transgenic Bt crops (Bt crops) for effective and environmentally safe pest control. The development of resistance to these insecticidal proteins is considered the most serious threat to the sustainability of Bt crops. Resistance in fall armyworm (Spodoptera frugiperda) populations from Puerto Rico to transgenic corn producing the Cry1Fa insecticidal protein resulted, for the first time in the United States, in practical resistance, and Bt corn was withdrawn from the local market. In this study, we used a field-collected Cry1Fa corn-resistant strain (456) of S. frugiperda to identify the mechanism responsible for field-evolved resistance. Binding assays detected reduced Cry1Fa, Cry1Ab, and Cry1Ac but not Cry1Ca toxin binding to midgut brush border membrane vesicles (BBMV) from the larvae of strain 456 compared to that from the larvae of a susceptible (Ben) strain. This binding phenotype is descriptive of the mode 1 type of resistance to Bt toxins. A comparison of the transcript levels for putative Cry1 toxin receptor genes identified a significant downregulation (>90%) of a membrane-bound alkaline phosphatase (ALP), which translated to reduced ALP protein levels and a 75% reduction in ALP activity in BBMV from 456 compared to that of Ben larvae. We cloned and heterologously expressed this ALP from susceptible S. frugiperda larvae and demonstrated that it specifically binds with Cry1Fa toxin. This study provides a thorough mechanistic description of field-evolved resistance to a transgenic Bt crop and supports an association between resistance and reduced Cry1Fa toxin binding and levels of a putative Cry1Fa toxin receptor, ALP, in the midguts of S. frugiperda larvae. PMID:26637593

Foetal antigen 2 (FA2) in the stromal reaction induced by breast carcinoma

DEFF Research Database (Denmark)

Rasmussen, H B; Teisner, B; Andersen, J A

1992-01-01

An indirect immunoperoxidase technique was used to examine the distribution of foetal antigen 2 (FA2), a recently described basement membrane (BM)-associated antigen, in invasive breast carcinoma (n = 34), fibroadenoma (n = 5) and normal breast tissue (n = 5), and to compare its distribution...... with that of laminin and collagen type IV. In normal breast tissue, FA2 was detected in the intralobular stroma as a broad band around acini and ducts, but was not present in the interlobular stroma. In areas of carcinoma in situ, FA2 was present diffusely around and in close contact with the glandular elements......, the staining being more intense than that found around normal glandular structures. Two distinct patterns of FA2 distribution were found in adenocarcinomas of the breast. In the fibroblast reaction type, fibroblast staining dominated, whilst in the stromal reaction type, intense and extensive staining...

The cathepsin B inhibitor z-FA-CMK induces cell death in leukemic T cells via oxidative stress.

Science.gov (United States)

Liow, K Y; Chow, Sek C

2018-01-01

The cathepsin B inhibitor benzyloxycarbonyl-phenylalanine-alanine-chloromethyl ketone (z-FA-CMK) was recently found to induce apoptosis at low concentrations in Jurkat T cells, while at higher concentrations, the cells die of necrosis. In the present study, we showed that z-FA-CMK readily depletes intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) generation. The toxicity of z-FA-CMK in Jurkat T cells was completely abrogated by N-acetylcysteine (NAC), suggesting that the toxicity mediated by z-FA-CMK is due to oxidative stress. We found that L-buthionine sulfoximine (BSO) which depletes intracellular GSH through the inhibition of GSH biosynthesis in Jurkat T cells did not promote ROS increase or induce cell death. However, NAC was still able to block z-FA-CMK toxicity in Jurkat T cells in the presence of BSO, indicating that the protective effect of NAC does not involve GSH biosynthesis. This is further corroborated by the protective effect of the non-metabolically active D-cysteine on z-FA-CMK toxicity. Furthermore, in BSO-treated cells, z-FA-CMK-induced ROS increased which remains unchanged, suggesting that the depletion of GSH and increase in ROS generation mediated by z-FA-CMK may be two separate events. Collectively, our results demonstrated that z-FA-CMK toxicity is mediated by oxidative stress through the increase in ROS generation.

Effect of façade systems on the performance of cooling ceilings: In situ measurements

Directory of Open Access Journals (Sweden)

Katharina Eder

2015-03-01

Full Text Available This article presents an innovative façade system designed to increase the thermal comfort inside an office room and to enhance the cooling capacity of the suspended cooling ceiling. A series of measurements is conducted in an existing office building with different façade systems (i.e., a combination of glazing and shading. An innovative façade system is developed based on this intensive set of measurements. The new system enhances the thermal comfort and cooling capacity of the suspended cooling ceiling. The main usage of the new system is the refurbishment and improvement of existing façade systems.

The challenge and impact of engaging hard-to-reach populations in regular physical activity and health behaviours: an examination of an English Premier League 'Football in the Community' men's health programme.

Science.gov (United States)

Curran, K; Drust, B; Murphy, R; Pringle, A; Richardson, D

2016-06-01

To investigate the challenges that men from hard-to-reach (HTR) populations encounter when attempting to commit to regular participation in physical activity and health behaviours, and to explore the psychological and social effects of participation in a twelve week football-led health improvement intervention. A twelve week football specific physical activity intervention targeting men from HTR populations was delivered by Everton Football Clubs' Football in the Community (FitC) scheme as part of a national programme of men's health delivered in/by English Premier League (EPL) football clubs. Men living in homeless shelters and/or recovering from substance misuse were recruited over a period of three months. The programme consisted of a two hour football session, twice weekly, alongside the dissemination of healthy living messages. Football sessions were conducted by a qualified FitC coach. This research was conducted during a twelve week period of immersed practitioner-research. Ethnographic and observational methodologies were adopted. Psychosocial issues were discussed with participants through informal client-researcher interactions and data were logged via field notes. Records of attendance were logged. Participants who failed to attend a session were contacted and their reason(s) for non-attendance were recorded. Data were analysed using deductive and inductive reasoning. Despite the apparent ambition of the participants to regularly participate in the FitC programme, adherence to the programme was poor. Economic, environmental and social barriers to engagement in the programme were apparent. Engagement in the programme resulted in positive psychosocial developments; the development of structure, social interaction and social capital. Community based football-led health improvement programmes endorsed by professional football clubs appear well positioned to connect with, and attract, men from HTR populations. The evidence suggests that such programmes can

The role of FaBG3 in fruit ripening and B. cinerea fungal infection of strawberry.

Science.gov (United States)

Li, Qian; Ji, Kai; Sun, Yufei; Luo, Hao; Wang, Hongqing; Leng, Ping

2013-10-01

In plants, β-glucosidases (BG) have been implicated in developmental and pathogen defense, and are thought to take part in abscisic acid (ABA) synthesis via hydrolysis of ABA glucose ester to release active ABA; however, there is no genetic evidence for the role of BG genes in ripening and biotic/abiotic stress in fruits. To clarify the role of BG genes in fruit, eight Fa/FvBG genes encoding β-glucosidase were isolated using information from the GenBank strawberry nucleotide database. Of the Fa/FvBG genes examined, expression of FaBG3 was the highest, showing peaks at the mature stage, coincident with the changes observed in ABA content. To verify the role of this gene, we suppressed the expression of FaBG3 via inoculation with Agrobacterium tumefaciens containing tobacco rattle virus carrying a FaBG3 fragment (RNAi). The expression of FaBG3 in FaBG3-RNAi-treated fruit was markedly reduced, and the ABA content was lower than that of the control. FaBG3-RNAi-treated fruit did not exhibit full ripening, and were firmer, had lower sugar content, and were pale compared with the control due to down-regulation of ripening-related genes. FaBG3-RNAi-treated fruit with reduced ABA levels were much more resistant to Botrytis cinerea fungus but were more sensitive to dehydration stress than control fruit. These results indicate that FaBG3 may play key roles in fruit ripening, dehydration stress and B. cinerea fungal infection in strawberries via modulation of ABA homeostasis and transcriptional regulation of ripening-related genes. © 2013 The Authors The Plant Journal © 2013 John Wiley & Sons Ltd.

Measurement of FA and VitB{sub 12} in serum by TRFIA and its clinical application

Energy Technology Data Exchange (ETDEWEB)

Jinhong, Zhou; Huimin, Wang [Affiliated Hospital of Nantong Univ., Nantong (China). Dept. of Laboratory Medicine

2006-03-15

To investigate the correlation between diseases and the quantity of folic acid(FA) and vitamine B{sub 12} (VitB{sub 12}) in serum, the quantity of FA and VitB{sub 12} in serum was measured by TR- FIA. The results showed that the levels of FA and VitB{sub 12} in 68 controlled subjects were 20.13{+-}5.72 nmol/L and 240.45{+-}58.23 pmol/L respectively. The levels of FA and VitB{sub 12} in 6 patients with megaloblastic anemia, 26 with medium-terminal gestation femineity, 7 with liver cirrhosis, 10 with gastric ulcerand 31 with cerebral infarction were significant lower than those in the control group. The level of FA in 24 with malignant hematopathy and 57 with malignant tumor was significantly lower but VitB{sub 12} between the 31 patients with iron deficiency anemia and 12 with CAA and the control group. The amount of the FA in 9 patients with chronic atrophic gastritis and 42 blood donors were lower than that in the control. The determination of FA and VitB{sub 12} levels may be quite significant in the diagnosis, therapy and prognosis of diseases. Laboratories should establish the reference values which fit the locals specifically. (authors)

Formal language of Lanna Shop House’s Façade in Lampang Old city, Thailand

Science.gov (United States)

Phetsuriya, Natthakit

2017-10-01

This article aims to presents ‘the formal architectural language of Lanna Designs” that is a linguistic paradigm for decrypt the linguistic system which is hidden in the Lanna façade style. Lanna Designs present an identity of vital ordered and crucial articulated formal language which inherently set of mathematical rules for the arrangement of ornaments. The scope of this article is attempted to the morphology of façades of the ten shop houses which located in Lampang Old city and have familiar proportion and style. In this article, the sampling of façade buildings required proportion as three-stall and two-story with familiar style. The morphology is described based on terms of a symbolic encoding system that is represented as graphically building grammar. The system helps to emphasize commonalities in façade languages and propose a prototype of identified Lanna façade design. This methodology might be the option for decrypt or study in every facades style.

A Conserved Metal Binding Motif in the Bacillus subtilis Competence Protein ComFA Enhances Transformation.

Science.gov (United States)

Chilton, Scott S; Falbel, Tanya G; Hromada, Susan; Burton, Briana M

2017-08-01

Genetic competence is a process in which cells are able to take up DNA from their environment, resulting in horizontal gene transfer, a major mechanism for generating diversity in bacteria. Many bacteria carry homologs of the central DNA uptake machinery that has been well characterized in Bacillus subtilis It has been postulated that the B. subtilis competence helicase ComFA belongs to the DEAD box family of helicases/translocases. Here, we made a series of mutants to analyze conserved amino acid motifs in several regions of B. subtilis ComFA. First, we confirmed that ComFA activity requires amino acid residues conserved among the DEAD box helicases, and second, we show that a zinc finger-like motif consisting of four cysteines is required for efficient transformation. Each cysteine in the motif is important, and mutation of at least two of the cysteines dramatically reduces transformation efficiency. Further, combining multiple cysteine mutations with the helicase mutations shows an additive phenotype. Our results suggest that the helicase and metal binding functions are two distinct activities important for ComFA function during transformation. IMPORTANCE ComFA is a highly conserved protein that has a role in DNA uptake during natural competence, a mechanism for horizontal gene transfer observed in many bacteria. Investigation of the details of the DNA uptake mechanism is important for understanding the ways in which bacteria gain new traits from their environment, such as drug resistance. To dissect the role of ComFA in the DNA uptake machinery, we introduced point mutations into several motifs in the protein sequence. We demonstrate that several amino acid motifs conserved among ComFA proteins are important for efficient transformation. This report is the first to demonstrate the functional requirement of an amino-terminal cysteine motif in ComFA. Copyright © 2017 American Society for Microbiology.

Betting, Forex Trading, and Fantasy Gaming Sponsorships-a Responsible Marketing Inquiry into the 'Gamblification' of English Football.

Science.gov (United States)

Lopez-Gonzalez, Hibai; Griffiths, Mark D

2018-01-01

Environmental stimuli in the form of marketing inducements to gamble money on sports have increased in recent years. The purpose of the present paper is to tackle the extended definition of the gamblification of sport using sponsorship and partnership deals of gambling, forex trading, and fantasy gaming as a proxy for assessing its environmental impact. Using data about sponsorship deals from English Football Premier League, the paper builds on the evidence of English football's gamblification process to discuss the impact that the volume, penetration, and marketing strategies of sports betting might have on public health and well-being. Findings demonstrate that gambling marketing has become firmly embedded in the financial practices of many Premiership football clubs. It is argued that such associations are not trivial, and that the symbolic linkage of sport and newer gambling forms can become an issue of public health, especially affecting vulnerable groups such as minors and problem gamblers. The present study is the first to explore in-depth the relationship and potential consequences and psychosocial impacts of sports-related marketing, particularly in relation to football.

A BPMN-based process map for the design and construction of façades

Directory of Open Access Journals (Sweden)

Eleanor Voss

2013-12-01

Full Text Available Corresponding author: Eleanor Voss, Glass and Façade Technology Research Group, Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, UK. E-mail: ev236@cam.ac.uk Process mapping can lead to significant efficiency and quality improvements in construction engineering and is an ideal basis for developing IT support tools. The increasing complexity and multidisciplinary nature of façade design and construction suggest that a process map would be beneficial in this sector of the construction industry, but it has received limited attention to date. This paper presents a verified process map of the façade design and construction process. The map is the first of its kind to represent, in detail, the whole process relevant to all façade types, from commencement of the façade consultant's and contactor's participation, to the end of their involvement. The paper describes the process by which the mapping notation was selected, followed by the development and verification of the process map, including testing in two independent research projects. The BuildingSMART's BPMN notation is found to have superior system features and comprehensibility for this application and the resulting process map is easy to interpret and verify by industry experts. The trialling of the map in the two research projects indicate that the map is a useful tool for assessing process improvements in the façades sector.

Disrupting Façades of Clarity in the Teaching and Learning of Qualitative Research

Directory of Open Access Journals (Sweden)

Melissa Contreras-McGavin

2013-02-01

Full Text Available In this article we examine two methodological façades of clarity that commonly shroud critical qualitative educational inquiry. More specifically, we interrogate discussions of reflexivity and positionality and explore the ways in which methodology curricula and instructional practices perpetuate façades of clarity, or a false sense of coherence, ultimately undermining the transformative potential of critical educational research. We identify specific pedagogical opportunities, spaces, and strategies for dismantling these façades and offer ways to reconstruct methodological practices congruent with the emancipatory and empowering aims of critical scholarship.

Flight Tests of a Ministick Controller in an F/A-18 Airplane

Science.gov (United States)

Stoliker, Patrick C.; Carter, John

2003-01-01

In March of 1999, five pilots performed flight tests to evaluate the handling qualities of an F/A-18 research airplane equipped with a small-displacement center stick (ministick) controller that had been developed for the JAS 39 Gripen airplane (a fighter/attack/ reconnaissance airplane used by the Swedish air force). For these tests, the ministick was installed in the aft cockpit (see figure) and production support flight control computers (PSFCCs) were used as interfaces between the controller hardware and the standard F/A-18 flight-control laws. The primary objective of the flight tests was to assess any changes in handling qualities of the F/A-18 airplane attributable to the mechanical characteristics of the ministick. The secondary objective was to demonstrate the capability of the PSFCCs to support flight-test experiments.

Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover

DEFF Research Database (Denmark)

Abdallah, Basem M; Bay-Jensen, Anne-Christine; Srinivasan, Bhuma

2011-01-01

We have recently identified delta-like 1/fetal antigen 1 (Dlk1/FA1) as a novel regulator of bone mass that functions to mediate bone loss under estrogen deficiency in mice. In this report, we investigated the effects of estrogen (E) deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s......-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (serum cross-linked C-telopeptide [s-CTX] and serum osteocalcin) were measured in two cohorts: a group of pre- and postmenopausal women (n = 100) and a group of postmenopausal women, where half had received...... estrogen-replacement therapy (ERT, n = 166). s-Dlk1/FA1 and s-CTX were elevated in postmenopausal E-deficient women compared with premenopausal E-replete women (both p ...

Detecting blind building façades from highly overlapping wide angle aerial imagery

Science.gov (United States)

Burochin, Jean-Pascal; Vallet, Bruno; Brédif, Mathieu; Mallet, Clément; Brosset, Thomas; Paparoditis, Nicolas

2014-10-01

This paper deals with the identification of blind building façades, i.e. façades which have no openings, in wide angle aerial images with a decimeter pixel size, acquired by nadir looking cameras. This blindness characterization is in general crucial for real estate estimation and has, at least in France, a particular importance on the evaluation of legal permission of constructing on a parcel due to local urban planning schemes. We assume that we have at our disposal an aerial survey with a relatively high stereo overlap along-track and across-track and a 3D city model of LoD 1, that can have been generated with the input images. The 3D model is textured with the aerial imagery by taking into account the 3D occlusions and by selecting for each façade the best available resolution texture seeing the whole façade. We then parse all 3D façades textures by looking for evidence of openings (windows or doors). This evidence is characterized by a comprehensive set of basic radiometric and geometrical features. The blindness prognostic is then elaborated through an (SVM) supervised classification. Despite the relatively low resolution of the images, we reach a classification accuracy of around 85% on decimeter resolution imagery with 60 × 40 % stereo overlap. On the one hand, we show that the results are very sensitive to the texturing resampling process and to vegetation presence on façade textures. On the other hand, the most relevant features for our classification framework are related to texture uniformity and horizontal aspect and to the maximal contrast of the opening detections. We conclude that standard aerial imagery used to build 3D city models can also be exploited to some extent and at no additional cost for facade blindness characterisation.

Analisis Pengaruh Kualitas Pelayanan Terhadap Kepuasan Pelanggan pada Hotel Santika Premiere Dyandra Medan

OpenAIRE

Purba, Mey Royani M.

2013-01-01

Quality of service is an expected level of excellence and control over the level of excellence to comply the customer wants. Satisfaction is the difference between the perceived performance with expectations. This study aimed to to identify and analyze the influence of the quality of services consisting of physical tangible, reliability, responsiveness, assurance, and empathy to customer satisfaction on Santika Premiere Dyandra Hotel. To measure service quality from the point of servic...

Black Generation Y gender differences in Premier Soccer League spectator motives : sport marketing

OpenAIRE

T.E. Mofokeng; A.L. Bevan-Dye

2014-01-01

The purpose of this study was to determine whether there are gender differences concerning Premier Soccer League (PSL) spectator motives amongst black Generation Y students in South Africa. In South Africa, the black Generation Y cohort (individuals born between 1986 and 2005) represents an important but under-researched market segment in that, in 2013, they made up 32 percent of the country's population. From a PSL marketing perspective, understanding the motives that drive game spectatorshi...

Fetal antigen 1 (FA1), a circulating member of the epidermal growth factor (EGF) superfamily

DEFF Research Database (Denmark)

Jensen, Charlotte Harken; Krogh, T N; Støving, René Klinkby

1997-01-01

We describe an ELISA technique for quantification of fetal antigen 1 (FA1), a glycoprotein belonging to the EGF-superfamily. The ELISA is based on immunospecifically purified polyclonal antibodies and has a dynamic range of 0.7-5.3 ng/ml, intra- and inter-assay C.V.s of less than 3.2% and an aver......We describe an ELISA technique for quantification of fetal antigen 1 (FA1), a glycoprotein belonging to the EGF-superfamily. The ELISA is based on immunospecifically purified polyclonal antibodies and has a dynamic range of 0.7-5.3 ng/ml, intra- and inter-assay C.V.s of less than 3.......2% and an average recovery of 105% in serum and 98% in urine. Comparison of FA1 in amniotic fluid, serum and urine revealed parallel titration curves, identical elution volumes following size chromatography, immunological identity and similar profiles when analysed by MALDI-MS. The reference interval for serum FA1...... was 12.3-46.6 ng/ml and the levels were 10 times higher in patients with renal failure. FA1 showed no diurnal variation, no variation during the menstrual cycle and was not influenced by the acute phase reaction. In humans (n = 10) the renal clearance of FA1 was 11 ml/min and an identical high renal...

A BPMN-Based Process Map for the Design and Construction of Façades

Directory of Open Access Journals (Sweden)

Eleanor Voss

2013-12-01

Full Text Available Process mapping can lead to significant efficiency and quality improvements in construction engineering and is an ideal basis for developing IT support tools. The increasing complexity and multidisciplinary nature of façade design and construction suggest that a process map would be beneficial in this sector of the construction industry, but it has received limited attention to date. This paper presents a verified process map of the façade design and construction process.  The map is the first of its kind to represent, in detail, the whole process relevant to all façade types, from commencement of the façade consultant’s and contactor’s participation, to the end of their involvement. The paper describes the process by which the mapping notation was selected, followed by the development and verification of the process map, including testing in two independent research projects. The BuildingSMART’s BPMN notation is found to have superior system features and comprehensibility for this application and the resulting process map is easy to interpret and verify by industry experts. The trialling of the map in the two research projects indicate that the map is a useful tool for assessing process improvements in the façades sector.

China English and ELT for English Majors

Science.gov (United States)

Zhang, Mingjuan

2008-01-01

This paper is a general study of one of varieties of English--China English and its influence on English Language Teaching (ELT) for English majors. The status of English as an International language breaks the situation in which British English or American English is the sole standard. English becomes World Englishes, taking on a plural form,…

Penerapan Perencanaan Pajak Penghasilan pada Fa Trico Paint Factory

Directory of Open Access Journals (Sweden)

Stefanus Ariyanto

2011-05-01

Full Text Available The most important parts of government income comes from taxes, especially income taxes. The different point of view arises between government and tax payer. While the government try to increase the tax income, the taxpayers always intend to minimize their tax burden by implementing tax management/plannning. This paper is a case study in FA Trico Paint Factory (FA TPF that try to reperforming company’s income tax return preparation with the main purpose to minimize company tax burden, while it is still comply with tax regulations in Indonesia. This approach could be an alternative for the company to restate it’s annual income tax return, to avoic fines and charges for not comply with the regulations, and minimize it’s income tax expense by approximately 10% per year. 

Making out in English (English phrasebook)

CERN Document Server

Crownover, Richard

2011-01-01

Making Out in English is a fun, accessible and thorough English phrase book and guide to the English language as it's really spoken. If you are a student, businessman or tourist traveling to the English speaking world and would like to have an authentic and meaningful experience, the key is being able to speak like a local. This friendly and easy-to-use English phrasebook makes this possible. Making Out in English has been revised and redesigned to act as a guide to modern colloquial English for use in everyday informal interactions—giving access to the sort of catchy English expressions that

Deterministic Assessment of Future Costs for Dismantling (FA)

Energy Technology Data Exchange (ETDEWEB)

Vasko, Marek [DECOM, Trnava (Slovakia)

2012-11-01

The main objective of the report is to provide an re-evaluation of cost calculations by OMEGA code for the Intermediate Storage for Spent Fuel in Studsvik (FA facility) using up-to-date Swedish labour cost unit factors and available up-to-date Swedish (or international) cost unit factors for consumables, materials and substances. Furthermore, evolution of other OMEGA database parameters concerning cost calculations e.g. manpower unit factors and workgroups parameters are taken into account. This report follows up former project which introduced tentative calculations of main decommissioning parameters such as costs, manpower and exposure of personnel for activities of older nuclear facility decommissioning in Sweden represented by FA Facility in Studsvik by means of calculation code OMEGA. The project demonstrated an implementation of advanced costing methodology based on PSL structure format to achieve transparent, traceable and comparable estimates even for older nuclear facilities like FA Facility in Studsvik. This former project used Slovak origin labour costs unit factors and other cost unit factors. After successful completion of this project, there was an intent of SSM to reevaluate calculations using an up-to-date Swedish labour cost data and also available Swedish consumables and materials cost data if available. Within this report re-calculations of main decommissioning parameters using available Swedish data are presented in structure according to Proposed Standardized List of Items for Costing Purposes. Calculations are made for decommissioning scenario with post-dismantling decontamination and steel radwaste melting technologies available at the site. All parameters are documented and summed up in both table and graphic forms in text and Annexes. Further, comparison of calculated results with previous calculations together with discussion is provided.

Deterministic Assessment of Future Costs for Dismantling (FA)

International Nuclear Information System (INIS)

Vasko, Marek

2012-03-01

The main objective of the report is to provide an re-evaluation of cost calculations by OMEGA code for the Intermediate Storage for Spent Fuel in Studsvik (FA facility) using up-to-date Swedish labour cost unit factors and available up-to-date Swedish (or international) cost unit factors for consumables, materials and substances. Furthermore, evolution of other OMEGA database parameters concerning cost calculations e.g. manpower unit factors and workgroups parameters are taken into account. This report follows up former project which introduced tentative calculations of main decommissioning parameters such as costs, manpower and exposure of personnel for activities of older nuclear facility decommissioning in Sweden represented by FA Facility in Studsvik by means of calculation code OMEGA. The project demonstrated an implementation of advanced costing methodology based on PSL structure format to achieve transparent, traceable and comparable estimates even for older nuclear facilities like FA Facility in Studsvik. This former project used Slovak origin labour costs unit factors and other cost unit factors. After successful completion of this project, there was an intent of SSM to reevaluate calculations using an up-to-date Swedish labour cost data and also available Swedish consumables and materials cost data if available. Within this report re-calculations of main decommissioning parameters using available Swedish data are presented in structure according to Proposed Standardized List of Items for Costing Purposes. Calculations are made for decommissioning scenario with post-dismantling decontamination and steel radwaste melting technologies available at the site. All parameters are documented and summed up in both table and graphic forms in text and Annexes. Further, comparison of calculated results with previous calculations together with discussion is provided

Flight Test of the F/A-18 Active Aeroelastic Wing Airplane

Science.gov (United States)

Voracek, David

2007-01-01

A viewgraph presentation of flight tests performed on the F/A active aeroelastic wing airplane is shown. The topics include: 1) F/A-18 AAW Airplane; 2) F/A-18 AAW Control Surfaces; 3) Flight Test Background; 4) Roll Control Effectiveness Regions; 5) AAW Design Test Points; 6) AAW Phase I Test Maneuvers; 7) OBES Pitch Doublets; 8) OBES Roll Doublets; 9) AAW Aileron Flexibility; 10) Phase I - Lessons Learned; 11) Control Law Development and Verification & Validation Testing; 12) AAW Phase II RFCS Envelopes; 13) AAW 1-g Phase II Flight Test; 14) Region I - Subsonic 1-g Rolls; 15) Region I - Subsonic 1-g 360 Roll; 16) Region II - Supersonic 1-g Rolls; 17) Region II - Supersonic 1-g 360 Roll; 18) Region III - Subsonic 1-g Rolls; 19) Roll Axis HOS/LOS Comparison Region II - Supersonic (open-loop); 20) Roll Axis HOS/LOS Comparison Region II - Supersonic (closed-loop); 21) AAW Phase II Elevated-g Flight Test; 22) Region I - Subsonic 4-g RPO; and 23) Phase II - Lessons Learned

Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa/fa rats.

Science.gov (United States)

Daubioul, Catherine; Rousseau, Nicolas; Demeure, Roger; Gallez, Bernard; Taper, Henryk; Declerck, Barbara; Delzenne, Nathalie

2002-05-01

This study was designed to compare the effects of dietary supplementation with nondigestible carbohydrates, differing in fermentability by colonic bacteria, on hepatic steatosis in growing obese Zucker rats. Male Zucker fa/fa rats were divided into three groups: a control group that received the basal diet, a fructan group that received 10 g highly fermented Synergy 1/100 g diet and a cellulose group that received 10 g poorly fermented Vivapur Microcrystalline cellulose/100 g diet. Rats consuming fructan had a lower energy intake, a lower body weight and less triacylglycerol accumulation in the liver as assessed in vivo by nuclear magnetic resonance (NMR) spectroscopy, and ex vivo by biochemical and histochemical analysis compared with the control and/or cellulose groups. The high fermentation of fructans compared with cellulose was reflected by greater cecal contents and by a twofold greater propionate concentration in the portal vein of rats fed fructan compared with those fed cellulose. By measuring the capacity of hepatocytes isolated from liver of Zucker rats to synthesize triglycerides or total lipids from different precursors, we showed that propionate, at the concentrations measured in the portal vein of rats treated with fructan, selectively decreased the incorporation of acetate into total lipids, a phenomenon that could contribute, along with the lower energy intake, to less triglyceride accumulation in the liver of obese Zucker rats fed dietary fructans.

The strawberry FaMYB1 transcription factor suppresses anthocyanin and flavonol accumulation in transgenic tobacco.

Science.gov (United States)

Aharoni, A; De Vos, C H; Wein, M; Sun, Z; Greco, R; Kroon, A; Mol, J N; O'Connell, A P

2001-11-01

Fruit ripening is characterized by dramatic changes in gene expression, enzymatic activities and metabolism. Although the process of ripening has been studied extensively, we still lack valuable information on how the numerous metabolic pathways are regulated and co-ordinated. In this paper we describe the characterization of FaMYB1, a ripening regulated strawberry gene member of the MYB family of transcription factors. Flowers of transgenic tobacco lines overexpressing FaMYB1 showed a severe reduction in pigmentation. A reduction in the level of cyanidin 3-rutinoside (an anthocyanin) and of quercetin-glycosides (flavonols) was observed. Expression of late flavonoid biosynthesis genes and their enzyme activities were adversely affected by FaMYB1 overexpression. Two-hybrid assays in yeast showed that FaMYB1 could interact with other known anthocyanin regulators, but it does not act as a transcriptional activator. Interestingly, the C-terminus of FaMYB1 contains the motif pdLNL(D)/(E)Lxi(G)/S. This motif is contained in a region recently proposed to be involved in the repression of transcription by AtMYB4, an Arabidopsis MYB protein. Our results suggest that FaMYB1 may play a key role in regulating the biosynthesis of anthocyanins and flavonols in strawberry. It may act to repress transcription in order to balance the levels of anthocyanin pigments produced at the latter stages of strawberry fruit maturation, and/or to regulate metabolite levels in various branches of the flavonoid biosynthetic pathway.

Filter-Adapted Fluorescent In Situ Hybridization (FA-FISH) for Filtration-Enriched Circulating Tumor Cells.

Science.gov (United States)

Oulhen, Marianne; Pailler, Emma; Faugeroux, Vincent; Farace, Françoise

2017-01-01

Circulating tumor cells (CTCs) may represent an easily accessible source of tumor material to assess genetic aberrations such as gene-rearrangements or gene-amplifications and screen cancer patients eligible for targeted therapies. As the number of CTCs is a critical parameter to identify such biomarkers, we developed fluorescent in situ hybridization (FISH) for CTCs enriched on filters (filter-adapted-FISH, FA-FISH). Here, we describe the FA-FISH protocol, the combination of immunofluorescent staining (DAPI/CD45) and FA-FISH techniques, as well as the semi-automated microscopy method that we developed to improve the feasibility and reliability of FISH analyses in filtration-enriched CTC.

Epidemiology and history of knee injury and its impact on activity limitation among football premier league professional referees.

Science.gov (United States)

Mahdavi Mohtasham, Hamid; Shahrbanian, Shahnaz; Khoshroo, Fatemeh

2018-01-01

The purpose of this study was to determine the epidemiology and history of knee injury and its impact on activity limitation among football premier league professional referees in Iran. This was a descriptive study. 59 Football Premier League professional referees participated in the study. The knee injury related information such as injury history and mechanism was recorded. Injury related symptoms and their impacts on the activity limitation, ability to perform activities of daily living as well participation in sports and recreational activities was obtained through the Knee Outcome Survey (KOS). The results indicated that 31 out of 59 participants reported the history of knee injury. In addition, 18.6%, 22.4% and 81% of the referees reported that they had been injured during the last 6 months of the last year, and at some point in their refereeing careers, respectively. Results further indicated that 48.8% of the injuries occurred in the non-dominant leg and they occurred more frequently during training sessions (52%). Furthermore, the value of KOS was 85 ± 13 for Activities of Daily Living subscale and 90 ± 9 for Sports and Recreational Activities subscale of the KOS. Knee injury was quite common among the Football Premier League professional referees. It was also indicated that the injuries occurred mainly due to insufficient physical fitness. Therefore, it is suggested that football referees undergo the proper warm-up program to avoid knee injury.

Slicing Method for curved façade and window extraction from point clouds

Science.gov (United States)

Iman Zolanvari, S. M.; Laefer, Debra F.

2016-09-01

Laser scanning technology is a fast and reliable method to survey structures. However, the automatic conversion of such data into solid models for computation remains a major challenge, especially where non-rectilinear features are present. Since, openings and the overall dimensions of the buildings are the most critical elements in computational models for structural analysis, this article introduces the Slicing Method as a new, computationally-efficient method for extracting overall façade and window boundary points for reconstructing a façade into a geometry compatible for computational modelling. After finding a principal plane, the technique slices a façade into limited portions, with each slice representing a unique, imaginary section passing through a building. This is done along a façade's principal axes to segregate window and door openings from structural portions of the load-bearing masonry walls. The method detects each opening area's boundaries, as well as the overall boundary of the façade, in part, by using a one-dimensional projection to accelerate processing. Slices were optimised as 14.3 slices per vertical metre of building and 25 slices per horizontal metre of building, irrespective of building configuration or complexity. The proposed procedure was validated by its application to three highly decorative, historic brick buildings. Accuracy in excess of 93% was achieved with no manual intervention on highly complex buildings and nearly 100% on simple ones. Furthermore, computational times were less than 3 sec for data sets up to 2.6 million points, while similar existing approaches required more than 16 hr for such datasets.

Fire protection concepts for Timber-Glass Composite façades

Directory of Open Access Journals (Sweden)

Schleicher Andreas

2016-01-01

The main objectives can be summarized as follows: Growth and densification in urban areas require the development of intelligent and resource-efficient building systems for “Smart Cities” of the future. By using timber-glass composites (TGC the primary energy demand of buildings can be reduced substantially. This research project examines the feasibility of applications of this new technology in multi-story and high-rise buildings. Critical aspects concerning fire protection such as flammability of timber elements, fire spread and failure of façade elements with bracing capacity will be analyzed. Different strategies will be developed in case studies and validated by structural analysis. Large scale mock ups of TGC façade elements will be checked on their suitability in fire tests. The findings of this research will lead to innovative fire safety concepts for building systems with TGC façades. Compliance with the high safety standards for multi-story buildings in urban areas like Vienna is one of the main objectives of this work. The adaptation of these fire safety concepts to the national standards of the neighboring countries will be continued subsequently. The gained knowledge should lead to further cooperation with companies for serial productions with TGC technology.

Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent

Science.gov (United States)

Jeppesen, J.; Albers, P. H.; Rose, A. J.; Birk, J. B.; Schjerling, P.; Dzamko, N.; Steinberg, G. R.; Kiens, B.

2011-01-01

The aim of this study was to investigate the molecular mechanisms regulating FA translocase CD36 (FAT/CD36) translocation and FA uptake in skeletal muscle during contractions. In one model, wild-type (WT) and AMP-dependent protein kinase kinase dead (AMPK KD) mice were exercised or extensor digitorum longus (EDL) and soleus (SOL) muscles were contracted, ex vivo. In separate studies, FAT/CD36 translocation and FA uptake in response to muscle contractions were investigated in the perfused rat hindlimb. Exercise induced a similar increase in skeletal muscle cell surface membrane FAT/CD36 content in WT (+34%) and AMPK KD (+37%) mice. In contrast, 5-aminoimidazole-4-carboxamide ribonucleoside only induced an increase in cell surface FAT/CD36 content in WT (+29%) mice. Furthermore, in the perfused rat hindlimb, muscle contraction induced a rapid (1 min, +15%) and sustained (10 min, +24%) FAT/CD36 relocation to cell surface membranes. The increase in cell surface FAT/CD36 protein content with muscle contractions was associated with increased FA uptake, both in EDL and SOL muscle from WT and AMPK KD mice and in the perfused rat hindlimb. This suggests that AMPK is not essential in regulation of FAT/CD36 translocation and FA uptake in skeletal muscle during contractions. However, AMPK could be important in regulation of FAT/CD36 distribution in other physiological situations. PMID:21297178

Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.

Science.gov (United States)

Legette, Leecole L; Luna, Arlyn Y Moreno; Reed, Ralph L; Miranda, Cristobal L; Bobe, Gerd; Proteau, Rosita R; Stevens, Jan F

2013-07-01

Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4 week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses of xanthohumol at 0, 1.86, 5.64, and 16.9 mg/kg BW for 6 weeks. All rats were maintained on a high fat (60% kcal) AIN-93G diet for 3 weeks to induce severe obesity followed by a normal AIN-93G (15% kcal fat) diet for the last 3 weeks of the study. Weekly food intake and body weight were recorded. Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein-1 (MCP-1) levels were assessed using commercial assay kits. Plasma and liver tissue levels of XN and its metabolites were determined by liquid-chromatography tandem mass spectrometry. Plasma and liver tissue levels of xanthohumol were similar between low and medium dose groups and significantly (peffect on body weight and plasma glucose levels. The highest dose group (n=6) had significantly lower plasma glucose levels compared to the control group (n=6) in male but not female rats. There was also a significant decrease in body weight for male rats in the highest dose group (16.9 mg/kg BW) compared to rats that received no xanthohumol, which was also not seen for female rats. Plasma cholesterol, insulin, triglycerides, and MCP-1 as well as food intake were not affected by treatment. The findings suggest that xanthohumol has beneficial effects on markers of metabolic syndrome. Copyright © 2012. Published by Elsevier Ltd.

EPS insulated façade fires from a fire and rescue perspective

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Kumm M.

2013-11-01

Full Text Available This paper highlights the challenges the fire and rescue services can meet at façade fires involving EPS insulation during construction and use of a building. The EPS characteristics are discussed in respect to the fire and rescue operation and results from orientating fire tests performed at a fire and rescue services training and test field are presented. Types of evacuation solutions, involving the fire and rescue services, where façade fires can delay or completely rule out the possibilities for safe evacuation, are presented. The restrictions in the Swedish building codes regarding use of combustible insulation are analysed and reflections over the practical problems with following the instructions to keep an EPS insulated façade safe through the building's whole lifespan are made. A number of occurred fires involving EPS are discussed and analysed from a fire and rescue perspective. Finally, recommendations are given for the fire and rescue services and future research fields are proposed.

Evaluation of Carbohydrate-Derived Fulvic Acid (CHD-FA) as a Topical Broad-Spectrum Antimicrobial for Drug-Resistant Wound Infections

Science.gov (United States)

2016-10-01

the newly formulated CHD-FA-Zn. Our initial results demonstrated that CHD-FA-Zn reduced microbial burdens of susceptible and drug- resistant planktonic...wound-associated drug resistant bacteria and fungi. Rat models of wound infection (open, and burn model) will be established with healthy animals ...Establish MIC90s for CHD-FA with clinical isolates of major drug resistant pathogens Assess CHD-FA in animal models of wound infection for major

Studies on fluctuating asymmetry (FA for certain morphological traits in four species of the Drosophila bipectinata complex

Directory of Open Access Journals (Sweden)

Banerjee Parul

2015-01-01

Full Text Available Fluctuating asymmetry (FA is defined as subtle deviations from perfect bilateral symmetry, evident in differences between the right and the left sides of any given trait. It is a pattern of variation between sides and measures developmental instability. Differences in the level of FA may be used for comparing developmental precision among closely related species and thus may give an idea whether developmental stability was affected during the divergence and separation of populations into distinct species. Keeping this in view, FA was studied in four species of the Drosophila bipectinata complex i.e. D. bipectinata, D. parabipectinata, D. malerkotliana and D. pseudoananassae. In females of all the four species, FA values did not vary significantly for any of the traits considered. However, in case of males, they varied significantly for Wing length (WL and sex comb tooth number (SCTN. Also, while in females Composite fluctuating asymmetry (CFA did not exhibit significant variation, in males it was found to vary significantly across the four species. However, Bonferroni t-tests did not reveal any consistent difference in FA levels between any two species. The magnitude of FA was found to differ significantly among traits and CFA values were found to be higher for males than females in all the four species. Therefore, it may be concluded that the level of FA shows trait specific variations and males are more prone to developmental perturbations. However, the FA levels are more or less similar in all the four species of this complex. Thus, developmental precision remains nearly same in all the four species of this complex irrespective of the degree of evolutionary divergence reached.

Prismatic TIR (total internal reflection) low-concentration PV (photovoltaics)-integrated façade for low latitudes

International Nuclear Information System (INIS)

Sabry, Mohamed

2016-01-01

Low-concentration Façade-integrated Photovoltaic system in the form of TIR (total internal reflection) prismatic segmented façade could play an effective role in reducing the direct component of solar radiation transmitting through buildings, hence reducing both cooling and artificial lighting load on such buildings. A prismatic segmented façade is capable of allowing diffused skylight to transmit through it to the building interior, while preventing most of the direct solar radiation and converting it into clean energy by means of the integrated PV (​photovoltaics) cells. A range of prismatic TIR segmented façades with different head angles has been designed based on the geographical latitude of the chosen location. Each façade configuration is simulated by ray-tracing technique and its performance is investigated against realistic direct solar radiation data in two clear sky days representing summer and winter of the targeted location. Ray tracing simulations revealed that all of the selected configurations could collect most of the direct solar radiation in summer. In contrary, larger head angle of the segmented façade could collect wider intervals around the noon time till reaching a head angle of 23° at which most of the incident direct solar radiation could be collected. - Highlights: • 5 different head angles of prismatic segmented PV-integrated Façade are ray-traced. • Transmitted and PV-collected solar radiation percentages are determined. • DNI daily profiles with associated solar altitudes and azimuth data are simulated. • Expected transmitted and PV collected solar radiation are calculated for the proposed segments.

Effects of carbon dioxide level (PCO2) on the fibrinolytic activity (FA) of pulmonary artery endothelial cells (PAEC)

International Nuclear Information System (INIS)

Langleben, D.; Moroz, L.A.; Danes, D.

1990-01-01

Recovery from pulmonary thromboembolism depends on the rapidity and completeness of clot lysis. This involves endogenous fibrinolytic mechanisms, particularly the balance between plasminogen activators and inhibitors produced by endothelial cells. Hypocapnia is common in pulmonary embolism, however it is not known if endothelial fibrinolytic function is affected by PCO 2 . The authors therefore measured the FA in medium (MCDB-131, 0.5% albumin) conditioned for 20 hours in-vitro by exposure to confluent cultures of bovine proximal PAEC. During conditioning, cells were exposed to 5% CO 2 in air (PCO 2 - 36-40mm Hg, CONTROL), or various PCO 2 levels (30-55 mmHg, in air). FA of conditioned medium was determined by 125 I-fibrin solid phase assay, with addition of plasminogen (10 ug/ml). With PCO 2 levels ≤ 35 mmHg, FA in the conditioned medium was 5 to 18% higher than CONTROL FA. When PCO 2 was ≥ 45 mmHg, FA decreased 5 to 60% as compared to CONTROL FA. There was a significant negative linear relationship between PCO 2 and FA. Thus, PCO 2 level can affect PAEC mediated plasminogen activation. This finding may be relevant to in-vivo clearance of clots from pulmonary arteries

Orientations of Iron-Sulfur Clusters FA and FB in the Homodimeric Type-I Photosynthetic Reaction Center of Heliobacterium modesticaldum.

Science.gov (United States)

Kondo, Toru; Matsuoka, Masahiro; Azai, Chihiro; Itoh, Shigeru; Oh-Oka, Hirozo

2016-05-12

Orientations of the FA and FB iron-sulfur (FeS) clusters in a structure-unknown type-I homodimeric heriobacterial reaction center (hRC) were studied in oriented membranes of the thermophilic anaerobic photosynthetic bacterium Heliobacterium modesticaldum by electron paramagnetic resonance (EPR), and compared with those in heterodimeric photosystem I (PS I). The Rieske-type FeS center in the cytochrome b/c complex showed a well-oriented EPR signal. Illumination at 14 K induced an FB(-) signal with g-axes of gz = 2.066, gy = 1.937, and gx = 1.890, tilted at angles of 60°, 60°, and 45°, respectively, with respect to the membrane normal. Chemical reduction with dithionite produced an additional signal of FA(-), which magnetically interacted with FB(-), with gz = 2.046, gy = 1.942, and gx = 1.911 at 30°, 60°, and 90°, respectively. The angles and redox properties of FA(-) and FB(-) in hRC resemble those of FB(-) and FA(-), respectively, in PS I. Therefore, FA and FB in hRC, named after their g-value similarities, seem to be located like FB and FA, not like FA and FB, respectively, in PS I. The reducing side of hRC could resemble those in PS I, if the names of FA and FB are interchanged with each other.

Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats.

Science.gov (United States)

Jiao, Jian; Bae, Eun Ju; Bandyopadhyay, Gautam; Oliver, Jason; Marathe, Chaitra; Chen, Michael; Hsu, Jer-Yuan; Chen, Yu; Tian, Hui; Olefsky, Jerrold M; Saberi, Maziyar

2013-04-01

Gastrointestinal bypass surgeries that result in rerouting and subsequent exclusion of nutrients from the duodenum appear to rapidly alleviate hyperglycemia and hyperinsulinemia independent of weight loss. While the mechanism(s) responsible for normalization of glucose homeostasis remains to be fully elucidated, this rapid normalization coupled with the well-known effects of vagal inputs into glucose homeostasis suggests a neurohormonally mediated mechanism. Our results show that duodenal bypass surgery on obese, insulin-resistant Zucker fa/fa rats restored insulin sensitivity in both liver and peripheral tissues independent of body weight. Restoration of normoglycemia was attributable to an enhancement in key insulin-signaling molecules, including insulin receptor substrate-2, and substrate metabolism through a multifaceted mechanism involving activation of AMP-activated protein kinase and downregulation of key regulatory genes involved in both lipid and glucose metabolism. Importantly, while central nervous system-derived vagal nerves were not essential for restoration of insulin sensitivity, rapid normalization in hepatic gluconeogenic capacity and basal hepatic glucose production required intact vagal innervation. Lastly, duodenal bypass surgery selectively altered the tissue concentration of intestinally derived glucoregulatory hormone peptides in a segment-specific manner. The present data highlight and support the significance of vagal inputs and intestinal hormone peptides toward normalization of glucose and lipid homeostasis after duodenal bypass surgery.

The influence of ventilated façade on sound insulation properties of envelope walls

Directory of Open Access Journals (Sweden)

Fišarová Zuzana

2017-01-01

Full Text Available Presented article deals with sound insulation properties of timber structures’ envelope walls. Particularly, the influence of heavy board ventilated façade on laboratory airborne sound insulation R and Rw in dB was studied. The installation method and gaps between façade boards can cause building defects originating in overrating the influence of ventilated cladding on envelope wall acoustic parameters. Real constructions were built for the experimental purposes and measurements, one with gaps between boards and one with simply eliminated gaps for mutual comparison. The results obtained were processed to make tables and graphs and to derive recommendations for the design of this type of constructions involving the general installation method of façade boards. Detailed results are depicted in conclusions.

Suppression of Human T Cell Proliferation Mediated by the Cathepsin B Inhibitor, z-FA-FMK Is Due to Oxidative Stress.

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Tanuja Rajah

Full Text Available The cathepsin B inhibitor, benzyloxycarbonyl-phenylalanine-alanine-fluoromethyl ketone (z-FA-FMK readily inhibits anti-CD3-induced human T cell proliferation, whereas the analogue benzyloxycarbonyl-phenylalanine-alanine-diazomethyl ketone (z-FA-DMK had no effect. In contrast, benzyloxycarbonyl-phenylalanine-alanine-chloromethyl ketone (z-FA-CMK was toxic. The inhibition of T cell proliferation mediated by z-FA-FMK requires not only the FMK moiety, but also the benzyloxycarbonyl group at the N-terminal, suggesting some degree of specificity in z-FA-FMK-induced inhibition of primary T cell proliferation. We showed that z-FA-FMK treatment leads to a decrease in intracellular glutathione (GSH with a concomitant increase in reactive oxygen species (ROS levels in activated T cells. The inhibition of anti-CD3-induced T cell proliferation mediated by z-FA-FMK was abolished by the presence of low molecular weight thiols such as GSH, N-acetylcysteine (NAC and L-cysteine, whereas D-cysteine which cannot be metabolised to GSH has no effect. The inhibition of anti-CD3-induced up-regulation of CD25 and CD69 expression mediated by z-FA-FMK was also attenuated in the presence of exogenous GSH. Similar to cell proliferation, GSH, NAC and L-cysteine but not D-cysteine, completely restored the processing of caspase-8 and caspase-3 to their respective subunits in z-FA-FMK-treated activated T cells. Our collective results demonstrated that the inhibition of T cell activation and proliferation mediated by z-FA-FMK is due to oxidative stress via the depletion of GSH.

Computer-simulation study on fire behaviour in the ventilated cavity of ventilated façade systems

Directory of Open Access Journals (Sweden)

Giraldo María P.

2013-11-01

Full Text Available Fire spread through the façades is widely recognized as one of the fastest pathways of fire spreading in the buildings. Fire may spread through the façade in different ways depending on the type of façade system and on the elements and materials from which it is constructed. Ventilated façades are multilayer systems whose main feature is the creation of an air chamber of circulating air between the original building wall and the external cladding. The “chimney effect” in the air cavity is a mechanism that improves the façade's thermal behaviour and avoids the appearance of moisture from rain or condensation. However, in a event of fire, it may contribute to the quickest spreading of fire, representing a significant risk to the upper floors of a building. This study deals with some aspects of fire propagation through the ventilated cavity in ventilated façade systems. Also we review the provisions stipulated by the Spanish building code (Código Técnico de la Edificación, CTE [1] to avoid fire spread outside the building. The results highlight the importance of the use of proper fire barriers to ensure the compartmentalization of the ventilated cavity, as well as the use of non-combustible thermal insulation materials, among others. In addition, based on the results, it might be considered that the measures stipulated by the CTE are insufficient to limit the risks associated with this kind of façades systems. The study has been performed using field models of computational fluid-dynamics. In particular, the Fire Dynamics Simulator (FDS software has been used to numerically solve the mathematical integration models.

Report to New England Governors and Eastern Canadian Premiers on climate change projects

International Nuclear Information System (INIS)

2002-08-01

The Premiers-Governors energy discussions are aimed at promoting joint energy cooperation between provinces and states. This report outlines the major accomplishments in the implementation of the Climate Change Action Plan adopted by the Conference in 1998. The project priorities for the coming year are also outlined. In 2001, the New England Governors (NEG) and the Eastern Canadian Premiers (ECP) directed the Environment Committee and the Northeast International Committee on Energy (NICE) to implement a plan to develop a regional emissions inventory so that participating jurisdictions would have common data for measuring progress. The plan also identified specific climate actions that could be readily implemented. This report describes the results of 5 working groups which were created to focus on the following potential categories: energy, transportation, inventory and registry, adaptation, and 'lead by example'. In addition to the working groups, the Climate Change Steering Committee developed 4 proposals for consideration for implementation. These were the LED Traffic Light Proposal, the College and University Partnerships in Emissions Reductions, State/Provincial Purchasing Programs for High Efficiency-Low Emission Office Equipment, and Use of Cleaner, More Energy-Efficient Vehicles in State/Provincial Fleets. The Steering Committee will also pursue other tasks in the coming year, including the study of other proposals for cost-effective measures that could contribute to the goals of the Climate Change Action Plan, examine Internet options for coordinating internal project work, examine opportunities to pursue climate action, and identify opportunities to improve vehicle fuel efficiency

Studies on watermelon somatic cell mutant of resistance to fusaric acid (FA) by low energy Ar+ ion beam irradiation

International Nuclear Information System (INIS)

Wang Haobo; Gu Yunhong; Cheng Guowang; Yu Zengliang

2003-01-01

Three kinds of watermelon seeds irradiated by Ar + ion beam (25 keV, 6.24 x 10 16 ions/cm 2 ) were inoculated in MS medium with 15 mg/L FA. Cotyledons from the sterile seedling as explants were inoculated in MS +BA 2.0 mg/L + FA 15 mg/L. And the adventitious shoots of resistance to FA were cultured in MS + NAA 0.2 mg/L + FA 15 mg/L. The results showed that both the irradiation of Ar + and FA affected the germination rate and seedling of watermelon line 3-27 and YH-5, and the joint effect of Ar + and FA showed an enhanced restraint. The adventitious shoot and rootage induction rate from the seeds irradiated by Ar + were respectively bigger than the unirradiated seeds in 3-27 and YH-5. The increasing ranges were different between two watermelon lines and between the shoot and rootage induction rates

Une forme urbaine du premier âge touristique: les promenades littorales

Directory of Open Access Journals (Sweden)

Franck DEBIÉ

1993-03-01

Full Text Available Les promenades maritimes caractérisent les stations de bord de mer du premier âge touristique (1850-1930. Elles traduisent dans le paysage un urbanisme spéculatif, à rapprocher de celui qui produit le square et le boulevard, et donnent lieu à une urbanisation du littoral sous forme de vastes appendices linéaires. Les pratiques sociales associées à la promenade rappellent celles du jardin de plaisir, et renvoient au même rêve d’une urbanité idéale, libérée des miasmes, des promiscuités sociales, des contraintes qui pèsent sur les amours et les jeux.

[Data mining analysis of professor Li Fa-zhi AIDS itchy skin medical record].

Science.gov (United States)

Wang, Dan-Ni; Li, Zhen; Xu, Li-Ran; Guo, Hui-Jun

2013-08-01

Analysis of professor Li Fa-zhi in the treatment of AIDS drug laws of itchy skin, provide the corresponding drug reference basis for Chinese medicine treatment of AIDS, skin itching. By using the method of analyzing the complex network of Weishi county, Henan in 2007 October to 2011 July during an interview with professor Li Fa-zhi treatment of AIDS patients with skin pruritus, etiology and pathogenesis analysis, skin itching AIDS syndrome differentiation of old Chinese medicine treatment and medication rule. The use of multi-dimensional query analysis, core drug skin itching AIDS treatment in this study as a windbreak, cicada slough, bupleurum, Qufeng solution table drug, licorice detoxification efficacy of drugs, Radix Scutellariae, Kochia scoparia, clearing away heat and promoting diuresis medicine; core prescription for Jingfang San streak virus. Professor Li Fa-zhi treatment of AIDS in the skin itching Qufeng solution table dehumidification antipruritic treatment.

Recoveries of rat lymph FA after administration of specific structured C-13-TAG

DEFF Research Database (Denmark)

Vistisen, Bodil; Mu, Huiling; Høy, Carl-Erik

2003-01-01

of intragastrically administered L*L*L*, M*M*M*, ML*M, and ML*L* (where * = C-13-labeled FA) in rats. Lymph lipids were separated into lipid classes and analyzed by GC combustion isotope ratio MS. The recoveries of lymph TAG 18:2n-6 8 h after administration of L*L*L*, ML*M, and ML*L* were 38.6, 48.4, and 49...... rapid recovery of exogenous long-chain FA following administration of specific structured TAG compared with long-chain TAG was probably due to fast hydrolysis. The lymphatic recovery of 8:0 was 2.2% 24 h after administration of M*M*M*. This minor lymphatic recovery of exogenous 8:0 was probably due...... to low stimulation of chylomicron formation. These results demonstrate tendencies toward faster lymphatic recovery of long-chain FA after administration of specific structured TAG compared with long-chain TAG....

Choosing the governing solutions for FA of AES-2006

International Nuclear Information System (INIS)

Vasilchenko, I.; Dragunov, Y.; Ryzhov, S.; Kobelev, S.; Vyalitsyn, V.; Troyanov, V.

2008-01-01

According to the program approved by the Government of Russia the AES-2006 design intended as a base one for the beginning of realization of the plans on development of the nuclear power engineering of Russia in the near future has been under way now. The most crucial components of the reactor plant are certainly the core and its basic component - FA. In the FA design such factors are concentrated that mainly define safety, profitability, adaptability to manufacture and operation of the fuel and NPP as a whole. As the nearest prototype for AES-2006 the TVS-2M design used at the Balakovo NPP is taken. The report shows on the basis of qualitative and quantitative evaluation that design of TVS-2 and its modifications TVS-2M are in the best compliance with the requirements of the project of the new RP AES-2006. This compliance is confirmed by the operational experience of the basic variant of the design

Mouse fetal antigen 1 (mFA1), the circulating gene product of mdlk, pref-1 and SCP-1: isolation, characterization and biology

DEFF Research Database (Denmark)

Bachmann, E; Krogh, T N; Højrup, P

1996-01-01

The mouse homologue to human fetal antigen 1 (hFA1) was purified from mouse amniotic fluid by cation exchange chromatography and immunospecific affinity chromatography. Mouse FA1 (mFA1) is a single chain glycoprotein with an M(r) of 42-50 kDa (SDS-PAGE). The N-terminal amino acid sequence (39...... residues) revealed 74% identity to hFA1 and 100% identity to the translated cDNAs referred to as mouse dlk, pref-1 and SCP-1. mFA1 is the secreted processed molecule encoded by the mRNA defined by these identical mouse cDNAs. Monospecific rabbit anti-mFA1 antibodies, purified by ammonium sulfate...... precipitation and immunospecific affinity chromatography, were used for immunohistochemical and quantitative ELISA techniques. The indirect immunoperoxidase technique demonstrated mFA1 within the endocrine structures of adult mouse pancreas, whereas the exocrine tissue remained unstained. FA1-positive staining...

Methodology for Thermal Behaviour Assessment of Homogeneous Façades in Heritage Buildings

Directory of Open Access Journals (Sweden)

Enrique Gil

2017-01-01

Full Text Available It is fundamental to study the thermal behaviour in all architectural constructions throughout their useful life, in order to detect early deterioration ensuring durability, in addition to achieving and maintaining the interior comfort with the minimum energy consumption possible. This research has developed a methodology to assess the thermal behaviour of façades in heritage buildings. This paper presents methodology validation and verification (V & V through a laboratory experiment. Guidelines and conclusions are extracted with the employment of three techniques in this experiment (thermal sensors, thermal imaging camera, and 3D thermal simulation in finite element software. A small portion of a homogeneous façade has been reproduced with indoor and outdoor thermal conditions. A closed chamber was constructed with wood panels and thermal insulation, leaving only one face exposed to the outside conditions, with a heat source inside the chamber that induces a temperature gradient in the wall. With this methodology, it is possible to better understand the thermal behaviour of the façade and to detect possible damage with the calibration and comparison of the results obtained by the experimental and theoretical techniques. This methodology can be extrapolated to the analysis of the thermal behaviour of façades in heritage buildings, usually made up of homogeneous material.

Dlk1/FA1 is a novel endocrine regulator of bone and fat mass and its serum level is modulated by growth hormone

DEFF Research Database (Denmark)

Abdallah, Basem; Ding, Ming; Jensen, Charlotte H

2007-01-01

Fat and bone metabolism are two linked processes regulated by several hormonal factors. Fetal antigen 1 (FA1) is the soluble form of dlk1 (delta-like 1), which is a member of the Notch-Delta family. We previously identified FA1 as a negative regulator of bone marrow mesenchymal stem cell...... differentiation. Here, we studied the effects of circulating FA1 on fat and bone mass in vivo by generating mice expressing high serum levels of FA1 (FA1 mice) using the hydrodynamic-based gene transfer procedure. We found that increased serum FA1 levels led to a significant reduction in total body weight, fat...... mass, and bone mass in a dose-dependent manner. Reduced bone mass in FA1 mice was associated with the inhibition of mineral apposition rate and bone formation rates by 58 and 72%, respectively. Because FA1 is colocalized with GH in the pituitary gland, we explored the possible modulation of serum FA1...

3D adaptable building skin : an invention for freedom in shape of façades

NARCIS (Netherlands)

Suma, A.B.

2006-01-01

This paper sets out to develop a principle on which a façade element can be deformed in shape. By using a flexible structure with cables, small bars and inflatable tubes, which together form a woven pattern, a 3D freedom of deformability results. The shape of the façade element can be manipulated

The catalytic kinetic method for the determination of trace formaldehyde (FA) base on a bromate-eosin Y system

Science.gov (United States)

Tang, Yufang; Chen, Hao; Weng, Chao; Tang, Xiaohui; Zhang, Miaoling; Yang, Qiongqiong; Hu, Tao; Cai, Changqun

A new simple and highly sensitive catalytic kinetic method for the determination of trace amount of FA in food sample has been established. The method was based on the catalytic effect of FA on the oxidation of eosin Y by potassium bromate in present of phosphoric acid. The reaction was monitored spectrophotometrically by measuring the decrease in absorbance of eosin Y at 518 nm. Under the optimized experimental conditions, the developed method allowed the determination of FA in the range of 0.03-0.6 μg mL-1 with a good precision, and the limit of detection was down to 0.00988 μg mL-1. The relative standard deviation of five replicate measurements for the determination of FA in concentration 0.12 μg mL-1 was 1.8%. The proposed method was successfully applied to the determination of FA in food directly and satisfactory results were obtained.

Formal characterizations of FA-based string processors

CSIR Research Space (South Africa)

Ngassam, EK

2010-08-01

Full Text Available stream_source_info Ngassam_2010.pdf.txt stream_content_type text/plain stream_size 7434 Content-Encoding UTF-8 stream_name Ngassam_2010.pdf.txt Content-Type text/plain; charset=UTF-8 Formal Characterizations of FA...-based String Processors Ernest Ketcha Ngassam1,2,?, Bruce W. Watson3, and Derrick G. Kourie3 1SAP Meraka UTD, Pretoria, South Africa 2School of Computing University of South Africa Pretoria 0001 ernest.ngassam@sap.com 3Department of Computer Science...

The effect of architectural façade design on energy savings in the student dormitory

Directory of Open Access Journals (Sweden)

Pejić Petar Č.

2014-01-01

Full Text Available There are many reasons for adequate use of natural light inside students' dormitories. Intensity of light required for student activities and temperature inside the rooms are the major factors for an occupant's comfortable work and life. Design of building façades has a significant impact both on the use of natural light and energy consumption. In this paper, a comparative analysis of student rooms with different orientations and different façade designs was performed in order to investigate what type of refurbishment in the façade is necessary. The goal of the refurbishment was generation of optimal thermal and lighting comfort for students' work with maximal energy saving for a new student dormitory in Nis, Serbia. An analysis of annual energy consumption of the newly designed student dormitory and proposed replacements on the exterior façade was performed by using the software EnergyPlus. Based on the energy consumption analysis it could be concluded that significant energy savings would be possible by upgrading the shading devices across the width of the window. In other words, changing the façade of the dorm could generally improve students' comfort, while the energy costs would be reduced. [Projekat Ministarstva nauke Republike Srbije, br. TR 36037: Development of student dorms in Serbia at the beginning of the 21st century i br. TR 33051: The concept of sustainable energy supply of settlements with energy efficient buildings

Fitness costs and stability of Cry1Fa resistance in Brazilian populations of Spodoptera frugiperda.

Science.gov (United States)

Santos-Amaya, Oscar F; Tavares, Clébson S; Rodrigues, João Victor C; Campos, Silverio O; Guedes, Raul Narciso C; Alves, Analiza P; Pereira, Eliseu José G

2017-01-01

The presence of fitness costs of resistance to Bacillus thuringiensis (Bt) insecticidal proteins in insect populations may delay or even reverse the local selection of insect resistance to Bt transgenic crops, and deserves rigorous investigation. Here we assessed the fitness costs associated with Cry1Fa resistance in two strains of fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae), derived from field collections in different Brazilian regions and further selected in the laboratory for high levels of resistance to Cry1Fa using leaves of TC1507 corn. Fitness components were compared using paired resistant and susceptible strains with similar genetic backgrounds and F 1 generations from reciprocal crosses, all of them reared on non-transgenic corn leaves. No apparent life history costs in the larval stage were observed in the Bt-resistant strains. Moreover, the resistance remained stable for seven generations in the absence of selection, with no decrease in the proportion of resistant individuals. Larval respiration rates were also similar between resistant and susceptible homozygotes, and heterozygotes displayed respiration rates and demographic performance equal or superior to those of susceptible homozygotes. In combination, these results indicate the lack of strong fitness costs associated with resistance to Cry1Fa in the fall armyworm strains studied. These findings suggest that Cry1Fa resistance in S. frugiperda populations is unlikely to be counterselected in Cry1Fa-free environments. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

In Plane Loaded Glass Panes in Façades, Temperature Loads in Fixed Bonded Glass Panes

NARCIS (Netherlands)

Huveners, E.M.P.; Herwijnen, van F.; Soetens, F.; Hofmeyer, H.; Vitkala, J.

2005-01-01

The author discusses the use of glass panes as transparent stability elements in vertical façade structures subjected to in-plane loads including temperature loads. In the present façade architecture, glass is normally used non-structural. The only mechanical requirement is to resist transversal

Protein source in a high-protein diet modulates reductions in insulin resistance and hepatic steatosis in fa/fa Zucker rats.

Science.gov (United States)

Wojcik, Jennifer L; Devassy, Jessay G; Wu, Yinghong; Zahradka, Peter; Taylor, Carla G; Aukema, Harold M

2016-01-01

High-protein diets are being promoted to reduce insulin resistance and hepatic steatosis in metabolic syndrome. Therefore, the effect of protein source in high-protein diets on reducing insulin resistance and hepatic steatosis was examined. Fa/fa Zucker rats were provided normal-protein (15% of energy) casein, high-protein (35% of energy) casein, high-protein soy, or high-protein mixed diets with animal and plant proteins. The high-protein mixed diet reduced area under the curve for insulin during glucose tolerance testing, fasting serum insulin and free fatty acid concentrations, homeostatic model assessment index, insulin to glucose ratio, and pancreatic islet cell area. The high-protein mixed and the high-protein soy diets reduced hepatic lipid concentrations, liver to body weight ratio, and hepatic steatosis rating. These improvements were observed despite no differences in body weight, feed intake, or adiposity among high-protein diet groups. The high-protein casein diet had minimal benefits. A high-protein mixed diet was the most effective for modulating reductions in insulin resistance and hepatic steatosis independent of weight loss, indicating that the source of protein within a high-protein diet is critical for the management of these metabolic syndrome parameters. © 2015 The Obesity Society.

Chinese Dream——Concert in Commemoration of 115th Birth Anniversary of Premier Zhou Enlai Held

Institute of Scientific and Technical Information of China (English)

Our; Staff; Reporter

2013-01-01

<正>The theme song of the film The Founding of a Republic sung by male vocalists Dai Yuqiang and Wei Song reverberated in the Opera Hall at the National Center for the Performing Arts on the `evening of March 14. It marked the start of the concert in commemoration of the 115th anniversary of the birth of Premier Zhou Enlai, with "Chinese Dream" as the theme.

FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression

DEFF Research Database (Denmark)

Tornehave, D; Jensen, Charlotte Harken; Teisner, B

1996-01-01

Fetal antigen 1 (FA1) is a glycoprotein containing six epidermal growth factor (EGF)-like repeats. It is closely similar to the protein translated from the human delta-like (dlk) cDNA and probably constitutes a proteolytically processed form of dlk. dlk is homologous to the Drosophila homeotic...... proteins delta and notch and to the murine preadipocyte differentiation factor Pref-1. These proteins participate in determining cell fate choices during differentiation. We now report that FA1 immunoreactivity is present in a number of neuroectodermally derived tumours as well as in pancreatic endocrine...... tumours. A negative correlation between FA1 and glucagon immunoreactants in these tumours prompted a reexamination of FA1 immunoreactants during fetal pancreatic development. At the earliest stages of development, FA1 was expressed by most of the non-endocrine parenchymal cells and, with ensuing...

Cercetări experimentale privind comportarea sistemelor pentru faţade, expuse la acţiunea focului

Directory of Open Access Journals (Sweden)

Ştefania Rădulescu

2010-12-01

Full Text Available Visually, it is often the goal of any architecture to define a personality or individual character through the design of the façade. This face or skin, wrapped to the structural frame beneath, is often key to an architect's desire to evoke our emotions, instilling a sense of grandeur as if each new building were an artist's sculpture. In recent decades the desire for taller structures and, particularly, those that are competing for recognition to be among the tallest, if not the world's tallest, is reason to review the fire safety issues related to façade or curtain wall design. Additionally, due to the creativity of architects, new and unique façade designs are continually appearing. The risk of fire spread through articulated elements of the façade or vertically around the façade via the mechanism of flame leap, poses new concerns for the newest class of super highrise structures. Our understanding of fire and its mechanisms of spread in buildings no longer eludes us, however, the risks of fire spread related to super high-rise buildings and the façades that define their character has not been well examined. Current code practices recognize the successful record of fully sprinkler protected high-rise buildings and only require that the void space between the curtain wall and the floor slab be resistive to fire spread using a perimeter fire barrier system.

Solution Validation for a Double Façade Prototype

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Pau Fonseca i Casas

2017-12-01

Full Text Available A Solution Validation involves comparing the data obtained from the system that are implemented following the model recommendations, as well as the model results. This paper presents a Solution Validation that has been performed with the aim of certifying that a set of computer-optimized designs, for a double façade, are consistent with reality. To validate the results obtained through simulation models, based on dynamic thermal calculation and using Computational Fluid Dynamic techniques, a comparison with the data obtained by monitoring a real implemented prototype has been carried out. The new validated model can be used to describe the system thermal behavior in different climatic zones without having to build a new prototype. The good performance of the proposed double façade solution is confirmed since the validation assures there is a considerable energy saving, preserving and even improving interior comfort. This work shows all the processes in the Solution Validation depicting some of the problems we faced and represents an example of this kind of validation that often is not considered in a simulation project.

Chao Fa Movies: The Transnational Production of Hmong American History and Identity by Ian G. Baird

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Ian Baird

2014-12-01

Full Text Available Films made by and for particular social and ethnic peoples can reveal a great deal about identity issues. Here, I examine the cultural production, the content, and the socio-cultural and political significance of three Chao Fa-inspired Hmong films produced at Khek Noi, Thailand by Hmong American producers working with largely Hmong Thai actors. The first two, Chao Fa 1 and 2, were directed in 2009 by Kou Thao. The third, Vaj Tuam Thawj – The Legend of Chao Fa, was put together by Jimmy Vang, in 2010. Even though these Chao Fa films are fictional, they attempt to depict events and circumstances that are familiar to many first generation Hmong Americans, and they can muster strong emotions from people who see them as depicting factual history. In addition, just like many other American youth, many 1.5 generation Hmong are tied together by shared media experiences, including Hmong movies. Thus, the Chao Fa movies are important for producing and reproducing, reinforcing and dispersing ideas related to Hmong American identity and culture. They tell stories of the Hmong being oppressed by many different groups, and this history suggests why many Hmong—not only the Chao Fa—have long desired the type of independence and freedom from prejudice and discrimination that they imagine would come if the Hmong only had their own nation state.

Verification of FA2D Prediction Capability Using Fuel Assembly Benchmark

International Nuclear Information System (INIS)

Jecmenica, R.; Pevec, D.; Grgic, D.; Konjarek, D.

2008-01-01

FA2D is 2D transport collision probability code developed at Faculty of Electrical Engineering and Computing, University Zagreb. It is used for calculation of cross section data at fuel assembly level. Main objective of its development was capability to generate cross section data to be used for fuel management and safety analyses of PWR reactors. Till now formal verification of code predictions capability is not performed at fuel assembly level, but results of fuel management calculations obtained using FA2D generated cross sections for NPP Krsko and IRIS reactor are compared against Westinghouse calculations. Cross section data were used within NRC's PARCS code and satisfactory preliminary results were obtained. This paper presents results of calculations performed for Nuclear Fuel Industries, Ltd., benchmark using FA2D, and SCALE5 TRITON calculation sequence (based on discrete ordinates code NEWT). Nuclear Fuel Industries, Ltd., Japan, released LWR Next Generation Fuels Benchmark with the aim to verify prediction capability in nuclear design for extended burnup regions. We performed calculations for two different Benchmark problem geometries - UO 2 pin cell and UO 2 PWR fuel assembly. The results obtained with two mentioned 2D spectral codes are presented for burnup dependency of infinite multiplication factor, isotopic concentration of important materials and for local peaking factor vs. burnup (in case of fuel assembly calculation).(author)

Dlk1/FA1 Is a Novel Endocrine Regulator of Bone and Fat Mass and Its Serum Level Is Modulated By Growth Hormone

DEFF Research Database (Denmark)

Abdallah, B.M.; Ding, M.; Jensen, C.H.

2007-01-01

Fat and bone metabolism are two linked processes regulated by several hormonal factors. FA1 (fetal antigen 1) is the soluble form of dlk1 (delta like 1), which is a member of the Notch-Delta family. We have previously identified FA1 as a negative regulator of bone marrow mesenchymal stem cell...... differentiation. Here, we studied the effects of circulating FA1 on fat and bone mass in vivo by generating mice expressing high serum levels of FA1 (FA1-mice) using the hydrodynamic-based gene transfer procedure (HGTP). We found that increased serum FA1 levels led to a significant reduction in total body weight......, fat mass and bone mass in a dose-dependent manner. Reduced bone mass in FA1-mice was associated with the inhibition of mineral apposition rate and bone formation rates by 58% and 72% respectively. Since FA1 is co-localized with growth hormone (GH) in the pituitary gland, we explored the possible...

ETV REPORT: REMOVAL OF CHEMICAL CONTAMINANTS IN DRINKING WATER – WATTS PREMIER INC. WP-4V DRINKING WATER TREATMENT SYSTEM

Science.gov (United States)

The Watts Premier WP-4V POU drinking water treatment system was tested for removal of aldicarb, benzene, cadmium, carbofuran, cesium, chloroform, dichlorvos, dicrotophos, fenamiphos, mercury, mevinphos, oxamyl, strontium, and strychnine. The WP-4V employs a reverse osmosis (RO) m...

Disease activity, physical function, and radiographic progression after longterm therapy with adalimumab plus methotrexate: 5-year results of PREMIER

NARCIS (Netherlands)

van der Heijde, Désirée; Breedveld, Ferdinand C.; Kavanaugh, Arthur; Keystone, Edward C.; Landewé, Robert; Patra, Kaushik; Pangan, Aileen L.

2010-01-01

To evaluate the efficacy and safety of initial combination treatment with adalimumab (ADA) and methotrexate (MTX) versus monotherapy with ADA or MTX during an open-label extension of PREMIER. Patients with early rheumatoid arthritis (RA) received blinded ADA plus MTX, ADA alone, or MTX alone for 2

Injury incidence in a Premier League youth soccer academy using the consensus statement: a prospective cohort study

Science.gov (United States)

Renshaw, Andrew

2016-01-01

Background There is an established risk of injury to young athletes exposed to high training loads. Identifying and monitoring injury risk is essential to aid prevention. The aim of this study was to use the consensus statement to determine the incidence and pattern of injury in 1 English Premier League soccer academy during 1 season. Methods A prospective cohort study included 181 elite academy soccer players during the 2012–2013 season. Players were divided into 5 age groups between 9 and 18 years. The number, type and incidence of injuries were recorded during matches and training. Incidence was calculated per 1000 hours of exposure. Results 127 injuries occurred during 29 346 hours of soccer exposure. 72% of injuries were non-contact related. Under (U)18 players sustained the highest number of match injuries. U12–14 players sustained the highest number of training injuries and injuries overall. U16 players sustained the highest number of severe injuries, and U18 players sustained the highest number of moderate injuries. U18 players sustained the highest number of injuries/1000 hours of training and overall. U15 players sustained the highest number of injuries/1000 hours of matches, the highest number of recurrent injuries and the highest incidence of recurrence. The most common injuries were muscle injuries in U15 and U18 players. The most common injury location was the anterior thigh, with the majority of these occurring in training. Conclusions Using the consensus statement, this study used a repeatable method to identify the injury profile of elite academy-level soccer players. PMID:27900186

A case report and literature review of Fanconi Anemia (FA) diagnosed by genetic testing.

Science.gov (United States)

Solomon, Ponnumony John; Margaret, Priya; Rajendran, Ramya; Ramalingam, Revathy; Menezes, Godfred A; Shirley, Alph S; Lee, Seung Jun; Seong, Moon-Woo; Park, Sung Sup; Seol, Dodam; Seo, Soo Hyun

2015-05-08

Fanconi anemia (FA) is a genetically heterogeneous rare autosomal recessive disorder characterized by congenital malformations, hematological problems and predisposition to malignancies. The genes that have been found to be mutated in FA patients are called FANC. To date 16 distinct FANC genes have been reported. Among these, mutations in FANCA are the most frequent among FA patients worldwide which account for 60- 65%. In this study, a nine years old male child was brought to our hospital one year ago for opinion and advice. He was the third child born to consanguineous parents. The mutation analyses were performed for proband, parents, elder sibling and the relatives [maternal aunt and maternal aunt's son (cousin)]. Molecular genetic testing [targeted next-generation sequencing (MiSeq, Illumina method)] was performed by mutation analysis in 15 genes involved. Entire coding exons and their flanking regions of the genes were analysed. Sanger sequencing [(ABI 3730 analyzer by Applied Biosystems)] was performed using primers specific for 43 coding exons of the FANCA gene. A novel splice site mutation, c.3066 + 1G > T, (IVS31 + 1G > T), homozygote was detected by sequencing in the patient. The above sequence variant was identified in heterozygous state in his parents. Further, the above sequence variant was not identified in other family members (elder sibling, maternal aunt and cousin). It is concluded that genetic study should be done if possible in all the cases of suspected FA, including siblings, parents and close blood relatives. It will help us to plan appropriate treatment and also to select suitable donor for hematopoietic stem cell transplantation and to plan for genetic counseling. In addition to the case report, the main focus of this manuscript was to review literature on role of FANCA gene in FA since large number of FANCA mutations and polymorphisms have been identified.

[Data mining analysis of professor Li Fa-zhi AIDS herpes zoster medical record].

Science.gov (United States)

Wang, Dan-Ni; Li, Zhen; Xu, Li-Ran; Guo, Hui-Jun

2013-08-01

Analysis of professor Li Fa-zhi in the treatment of AIDS drug laws of herpes zoster and postherpetic neuralgia, provide reference for the use of Chinese medicine treatment of AIDS, herpes zoster and postherpetic neuralgia. By using the method of analyzing the complex network of Weishi county, Henan in 2007 October to 2011 July during an interview with professor Li Fa-zhi treatment of AIDS of herpes zoster and postherpetic neuralgia patients, patients are input structured clinical information collection system, into the analysis of the data, carries on the research analysis theory of traditional Chinese medicine compatibility system algorithm and complex network analysis the use of complex networks. The use of multi-dimensional query analysis of AIDS drugs, the core of herpes zoster and postherpetic neuralgia treated in this study are Scutellariae Radix, Glucyrrhizae Radix, Carthame Flos, Plantaginis Semen, Trichosamthis Fructus, Angelicae Sinensis Radix, Gentianae Radix; core prescription for Longdan Xiegan decoction and Trichosanthes red liquorice decoction. Professor Li Fa-zhi treatment of AIDS, herpes zoster and postherpetic neuralgia by clearing heat and removing dampness and activating blood circulation to.

An Experimental Study on Mitigating Alkali Silica Reaction by Using Fly Ash (FA in Combination with Silica Fume and Expanded Perlite Powder (EPP

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Isneini Mohd

2016-01-01

Full Text Available ASR suppression by FA, SF, EPP, FA in combination with SF and EPP were evaluated by both mortar bar and concrete prism test. Mortar bars were made based on JIS A 1146, meanwhile concrete prism bars were casted in accordance with Rilem AAR-3. Both specimens were stored in 40°C 100% R.H. controlled room. Mortar and concrete mixtures used reactive aggregate in pessimum proportion. The results indicated that FA in combination with SF and EPP showed smaller expansion compared to FA. The best of concrete mixtures in reducing expansion is combination of FA with SF (FA15SF10.

Etat des lieux des soins de premier recours des malades mentaux à Antananarivo : étude rétrospective

Science.gov (United States)

Bakohariliva, Hasina Andrianarivony; Rafehivola, Imisanavalona Hanitrinihaja; Raobelle, Evah Norotiana; Raharivelo, Adeline; Rajaonarison, Bertille Hortense

2018-01-01

Résumé Religion et guérisseurs traditionnels occupent encore une place prépondérante dans la prise en charge des maladies mentales à Madagascar. Ainsi, nous nous sommes fixés comme objectif d'établir un état des lieux sur les soins de premier recours des malades mentaux. Nous avons mené une étude rétrospective descriptive s'étalant sur une période de 16 mois allant de janvier 2014 en avril 2015 au sein du service de psychiatrie du CHU de Befelatanana à Antananarivo. La prévalence des psychoses était de 25%. Le genre féminin (53%), l'ethnie merina (77%), les étudiants (45%), le niveau d'étude secondaire (40%), les célibataires (72%), la religion protestante (45%), ainsi que le niveau socio-économique moyen (57,5%) étaient prédominants. Dans les paramètres cliniques, le mode de début brutal (52%), le premier recours à la religion (40%), la présence d'antécédents des cas similaire (90%), étaient majoritaires. La schizophrénie était la pathologie la plus rencontrée dans la moitié des cas. Le délai d'amélioration en cas de traitement religieux et traditionnels était dans la moitié des cas de plus de 10 jours d'hospitalisation. Les patients ayant reçu une prise en charge psychiatrique en premier recours, étaient améliorés dans 75 % cas en moins de 10jours. Le retard du recours aux soins psychiatriques est une réalité à Madagascar qui aggrave le pronostic des psychoses. PMID:29632623

[Pierre Chirac "premier physician" of the king and the aborted plan to create an "Académie de médecine" in Paris (1731-1732)].

Science.gov (United States)

Lunel, Alexandre

2005-03-01

After being appointed "premier physician" in 1731, Pierre Chirac, thanks to his influence with the king, tried to realize an ambitious project. Inspired by the creation of an Academie de Chirurgie by the "premier surgeon", Chirac decided to creation an Académie de Médecine in Paris. Under his guidance, it was planned to collect opinions from all doctors of the kingdom in order to enhance global knowledge of disease, symptoms and treatments. However, threatened with the loss of its secular superiority, the Paris University Medical School immediately opposed the project. Although well advanced, the project was finally abandoned on Chirac's death.

Distribution of medium-chain FA in different lipid classes after administration of specific structured TAG in rats

DEFF Research Database (Denmark)

Mu, Huiling; Høy, Carl-Erik

2002-01-01

Structured TAG (STAG) containing medium-chain FA (MCFA) in the sn-1,3 positions and essential FA in the sn-2 position were synthesized by lipase-catalyzed acidolysis. In our previous studies we found that part of the MCFA from STAG could be absorbed in the small intestine; however, it was unclear...... how they were absorbed. In order to get a better understanding of the metabolism of STAG to improve future design and application of STAG, in the present study lymph lipids collected after feeding STAG were fractionated into different classes and the FA composition of each lipid class was studied...

Premier League academy soccer players' experiences of competing in a tournament bio-banded for biological maturation.

Science.gov (United States)

Cumming, Sean P; Brown, Daniel J; Mitchell, Siobhan; Bunce, James; Hunt, Dan; Hedges, Chris; Crane, Gregory; Gross, Aleks; Scott, Sam; Franklin, Ed; Breakspear, Dave; Dennison, Luke; White, Paul; Cain, Andrew; Eisenmann, Joey C; Malina, Robert M

2018-04-01

Individual differences in the growth and maturation have been shown to impact player performance and development in youth soccer. This study investigated Premier League academy players' experiences of participating in a tournament bio-banded for biological maturation. Players (N = 66) from four professional soccer clubs aged 11 and 14 years and between 85-90% of adult stature participated in a tournament. Players competed in three 11 vs 11 games on a full size pitch with 25-min halves. Sixteen players participated in four 15-min focus groups and were asked to describe their experiences of participating in the bio-banded tournament in comparison to age group competition. All players described their experience as positive and recommended the Premier League integrate bio-banding into the existing games programme. In comparison to age-group competitions, early maturing players described the bio-banded games more physically challenging, and found that they had to adapt their style of play placing a greater emphasis on technique and tactics. Late maturing players considered the games to be less physically challenging, yet appreciated the having more opportunity to use, develop and demonstrate their technical, physical, and psychological competencies. Bio-banding strategies appear to contribute positively towards the holistic development of young soccer players.

Neurons in the monoaminergic nuclei of the rat and human central nervous system express FA1/dlk

DEFF Research Database (Denmark)

Jensen, Charlotte Harken; Meyer, M; Schrøder, Henrik Daa

2001-01-01

The gene DLK1 encodes a member of the epidermal growth factor (EGF) superfamily, delta-like (dlk). When exposed in vivo to the action of an unknown protease, this type 1 membrane protein generates a soluble peptide referred to as Fetal antigen 1 (FA1). By acting in juxtacrine as well as paracrine....../autocrine manners, both forms have been shown to be active in the differentiation/proliferation process of various cell types. In adults, FA1/dlk has been demonstrated mainly within (neuro) endocrine tissues. In this study we investigated the presence of FA1/dlk in other parts of the developing and adult rat...... and human CNS. Using immunocytochemistry and in situ hybridization we found that in both species FA1/dlk was expressed in neurons of the Edinger-Westphal's nucleus as well as in substantia nigra, ventral tegmental area (VTA), locus coeruleus and in certain parts of the raphe nuclei....

Production Support Flight Control Computers: Research Capability for F/A-18 Aircraft at Dryden Flight Research Center

Science.gov (United States)

Carter, John F.

1997-01-01

NASA Dryden Flight Research Center (DFRC) is working with the United States Navy to complete ground testing and initiate flight testing of a modified set of F/A-18 flight control computers. The Production Support Flight Control Computers (PSFCC) can give any fleet F/A-18 airplane an in-flight, pilot-selectable research control law capability. NASA DFRC can efficiently flight test the PSFCC for the following four reasons: (1) Six F/A-18 chase aircraft are available which could be used with the PSFCC; (2) An F/A-18 processor-in-the-loop simulation exists for validation testing; (3) The expertise has been developed in programming the research processor in the PSFCC; and (4) A well-defined process has been established for clearing flight control research projects for flight. This report presents a functional description of the PSFCC. Descriptions of the NASA DFRC facilities, PSFCC verification and validation process, and planned PSFCC projects are also provided.

English Lecturer’s Attitude Toward English Variety In English Learning

Directory of Open Access Journals (Sweden)

Rahma Yanti

2018-04-01

Full Text Available This research investigates English lecturers’ attitude toward the variation of English in the process of English learning. The purpose of this study is to discuss the types of English variations uttered by English lecturers who are considered as respondents in this study and their attitudes toward the variations of language that appear to their own speech during the teaching-learning process. This research is descriptive by using qualitative approach. The data to be presented in this research is taken from several words of Indonesian lecturers at several universities in Padang West Sumatra by distributing some questionnaires and also interviews. The method of data analysis is divided into two types, first, methods which related to the correlation of external language objects with a non-linguistic element called correlation method or method of matching, and secondly, methods which related to surgical, processing or internal verbal tampering called the method of operation or distribution method.

Porušená funkce insulinové signalizační kaskády a zvýšená patologická fosforylace proteinu Tau v hipokampu starých fa/fa (Zucker) potkanů

Czech Academy of Sciences Publication Activity Database

Špolcová, Andrea; Mikulášková, B.; Kršková, K.; Gajdošechová, L.; Zórad, Š.; Olszanecki, R.; Maletínská, Lenka; Železná, Blanka

2013-01-01

Roč. 107, č. 5 (2013), s. 440-441 ISSN 0009-2770. [Mezioborové setkání mladých biologů, biochemiků a chemiků /13./. 14.5.2013-17.5.2013, Žďár nad Sázavou] R&D Projects: GA ČR GAP303/12/0576 Institutional support: RVO:61388963 Keywords : fa/fa rats * Tau protein * insulin resistance * leptin resistance Subject RIV: CE - Biochemistry

Quantitative diffusion tensor MR imaging of the brain: field strength related variance of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) scalars

International Nuclear Information System (INIS)

Huisman, Thierry A.G.M.; Loenneker, Thomas; Barta, Gerd; Bellemann, Matthias E.; Hennig, Juergen; Fischer, Joachim E.; Il'yasov, Kamil A.

2006-01-01

The objectives were to study the ''impact'' of the magnetic field strength on diffusion tensor imaging (DTI) metrics and also to determine whether magnetic-field-related differences in T2-relaxation times of brain tissue influence DTI measurements. DTI was performed on 12 healthy volunteers at 1.5 and 3.0 Tesla (within 2 h) using identical DTI scan parameters. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were measured at multiple gray and white matter locations. ADC and FA values were compared and analyzed for statistically significant differences. In addition, DTI measurements were performed at different echo times (TE) for both field strengths. ADC values for gray and white matter were statistically significantly lower at 3.0 Tesla compared with 1.5 Tesla (% change between -1.94% and -9.79%). FA values were statistically significantly higher at 3.0 Tesla compared with 1.5 Tesla (% change between +4.04 and 11.15%). ADC and FA values are not significantly different for TE=91 ms and TE=125 ms. Thus, ADC and FA values vary with the used field strength. Comparative clinical studies using ADC or FA values should consequently compare ADC or FA results with normative ADC or FA values that have been determined for the field strength used. (orig.)

Weekly infusional high-dose fluorouracil (HD-FU), HD-FU plus folinic acid (HD-FU/FA), or HD-FU/FA plus biweekly cisplatin in advanced gastric cancer: randomized phase II trial 40953 of the European Organisation for Research and Treatment of Cancer Gastrointestinal Group and the Arbeitsgemeinschaft Internistische Onkologie.

Science.gov (United States)

Lutz, Manfred P; Wilke, Hansjochen; Wagener, D J Theo; Vanhoefer, Udo; Jeziorski, Krzysztof; Hegewisch-Becker, Susanna; Balleisen, Leopold; Joossens, Eric; Jansen, Rob L; Debois, Muriel; Bethe, Ullrich; Praet, Michel; Wils, Jacques; Van Cutsem, Eric

2007-06-20

This multicentric, randomized, two-stage phase II trial evaluated three simplified weekly infusional regimens of fluorouracil (FU) or FU plus folinic acid (FA) and cisplatin (Cis) with the aim to select a regimen for future phase III trials. A total of 145 patients with advanced gastric cancer where randomly assigned to weekly FU 3,000 mg/m2/24 hours (HD-FU), FU 2,600 mg/m2/24 hours plus dl-FA 500 mg/m2 or l-FA 250 mg/m2 (HD-FU/FA), or FU 2000 mg/m2/24 hours plus FA plus biweekly Cis 50 mg/m2, each administered for 6 weeks with a 1-week rest. The primary end point was the response rate. Confirmed responses were observed in 6.1% (two of 33) of the eligible patients treated with HD-FU, in 25% (12 of 48, including one complete remission [CR]) with HD-FU/FA, and in 45.7% (21 of 46, including four CRs) with HD-FU/FA/Cis. The HD-FU arm was closed after stage 1 because the required minimum number of responses was not met. The median progression-free survival of all patients in the HD-FU, HD-FU/FA, and HD-FU/FA/Cis arm was 1.9, 4.0, and 6.1 months, respectively. The median overall survival was 7.1, 8.9, and 9.7 months, and the survival rate at 1 year was 24.3%, 30.3%, and 45.3%, respectively. Grade 4 toxicities were rare. The most relevant grade 3/4 toxicities were neutropenia in 1.9%, 5.4%, and 19.6%, and diarrhea in 2.7%, 1.9%, and 3.9% of the cycles in the HD-FU, HD-FU/FA, and HD-/FU/Cis arms, respectively. Weekly infusional FU/FA plus biweekly Cis is effective and safe in patients with gastric cancer.

The effect of architectural façade design on energy savings in the student dormitory

OpenAIRE

Pejić Petar Č.; Petković Dušan Lj.; Krasić Sonja M.

2014-01-01

There are many reasons for adequate use of natural light inside students' dormitories. Intensity of light required for student activities and temperature inside the rooms are the major factors for an occupant's comfortable work and life. Design of building façades has a significant impact both on the use of natural light and energy consumption. In this paper, a comparative analysis of student rooms with different orientations and different façade designs wa...

Molecular causes and consequences of genetic instability with respect to the FA/BRCA Caretaker Pathway

OpenAIRE

Neveling, Kornelia

2012-01-01

In the context of this thesis, I investigated the molecular causes and functional consequences of genetic instability using a human inherited disease, Fanconi anemia. FA patients display a highly variable clinical phenotype, including congenital abnormalities, progressive bone marrow failure and a high cancer risk. The FA cellular phenotype is characterized by spontaneous and inducible chromosomal instability, and a typical S/G2 phase arrest after exposure to DNA-damaging agents. So far, 13 g...

Growth, physicochemical properties, and morphogenesis of Chinese wild-type PRV Fa and its gene-deleted mutant strain PRV SA215

Directory of Open Access Journals (Sweden)

Tang Shanhu

2011-06-01

Full Text Available Abstract Background PRV Fa is common in China and causes most of the pseudorabies in the pig industry. A PRV SA215 strain with deleted gE, gI, and TK genes was constructed to develop a commercial attenuated live vaccine. However, the physicochemical properties, growth pattern, penetration kinetics, and morphogenesis of the PRV SA215 and its parental PRV Fa strain are unclear. Results A series of experiments were conducted to characterize both strains and provide more information. PRV Fa and PRV SA215 were found to have similar penetration patterns, with about 5 min half-time of penetration. The SA215 strain exhibited a slight delay in entry compared with PRV Fa. In the one-step growth test, the titers of the SA215 strain were first detected at 8 h, rapidly increased, and peaked at 12 h. A plateau was formed between 12-36 h of culturing. PRV SA215 showed delayed replication and approximately 10-30-fold lower titers during 0-16 h of culturing compared with the PRV-Fa strain. After 16 h, the PRV Fa titers dramatically decreased, whereas those of PRV SA215 were prolonged to 36 h and reached a titer value equal to that of PRV Fa and then decreased. Both strains were sensitive to both heat and acid-alkali treatments; however, PRV Fa was relatively more stable to heat treatment than PRV SA215. Both strains could propagate in the cultures with pH values from 5.0 to 9.0. Cultures with pH below 3.0 or above 11.0 were fatal to both strains. Both strains had considerable resistance to freeze-thawing treatments. Morphogenetic investigations showed that typical phases in the maturation pathway were observed in the PRV Fa-infected PK15 cells, whereas secondary envelopment was not observed in the PRV SA215 strain. Instead, capsid aggregations with concomitants of electrodense materials were observed. Conclusions These results suggest that PRV SA215 is a promising strain for vaccine development

Test cell data-based predictive modelling to determine HVAC energy consumption for three façade solutions in Madrid

Directory of Open Access Journals (Sweden)

J. Guerrero-Rubio

2018-01-01

Full Text Available This study aims to narrow the gap between predicted and actual energy performance in buildings. Predictive models were established that relate the electric consumption by HVAC systems to maintain certain indoor environmental conditions in variable weather to the type of façade. The models were developed using data gathered from test cells with adiabatic envelopes on all but the façade to be tested. Three façade types were studied. The first, the standard solution, consisted in a double wythe brick wall with an intermediate air space, the configuration most commonly deployed in multi-family dwellings built in Spain between 1940 and 1980 (prior to the enactment of the first building codes that limited overall energy demand in buildings. The other two were retrofits frequently found in such buildings: ventilated façades and ETICS (external thermal insulation composite systems. Two predictive models were designed for each type of façade, one for summer and the other for winter. The linear regression equations and the main statistical parameters are reported.

Differential protection of Cry1Fa toxin against Spodoptera frugiperda larval gut proteases by cadherin orthologs correlates with increased synergism.

Science.gov (United States)

Rahman, Khalidur; Abdullah, Mohd Amir F; Ambati, Suresh; Taylor, Milton D; Adang, Michael J

2012-01-01

The Cry proteins produced by Bacillus thuringiensis (Bt) are the most widely used biopesticides effective against a range of crop pests and disease vectors. Like chemical pesticides, development of resistance is the primary threat to the long-term efficacy of Bt toxins. Recently discovered cadherin-based Bt Cry synergists showed the potential to augment resistance management by improving efficacy of Cry toxins. However, the mode of action of Bt Cry synergists is thus far unclear. Here we elucidate the mechanism of cadherin-based Cry toxin synergism utilizing two cadherin peptides, Spodoptera frugiperda Cad (SfCad) and Manduca sexta Cad (MsCad), which differentially enhance Cry1Fa toxicity to Spodoptera frugiperda neonates. We show that differential SfCad- and MsCad-mediated protection of Cry1Fa toxin in the Spodoptera frugiperda midgut correlates with differential Cry1Fa toxicity enhancement. Both peptides exhibited high affinity for Cry1Fa toxin and an increased rate of Cry1Fa-induced pore formation in S. frugiperda. However, only SfCad bound the S. frugiperda brush border membrane vesicle and more effectively prolonged the stability of Cry1Fa toxin in the gut, explaining higher Cry1Fa enhancement by this peptide. This study shows that cadherin fragments may enhance B. thuringiensis toxicity by at least two different mechanisms or a combination thereof: (i) protection of Cry toxin from protease degradation in the insect midgut and (ii) enhancement of pore-forming ability of Cry toxin.

Reconsidering English Grammar Teaching for Improving Non-English Majors' English Writing Ability

Science.gov (United States)

Shen, Yuru

2012-01-01

With the globalization of world economy, English learners' writing ability has been attached less and less importance. As a result, many college students in China, especially the non-English majors, cannot express themselves effectively in written English. They make various kinds of mistakes, mostly grammar mistakes, such as writing sentence…

Monitoring evaluation of a spillway pilaster for Premiere Chute Dam

Energy Technology Data Exchange (ETDEWEB)

Crepeau, Louis; Kassem, Chakib [OSMOS Canada Inc., Montreal, (Canada)

2010-07-01

The Premiere-Chute hydroelectric power station, commissioned in 1968, has four hydraulic turbines for a total of 130 MW. One of the pilasters of the dam weir, built with pre-stressed concrete, showed a crack at the level of the post-tension cable. This paper presented an evaluation of the behaviour of the pilaster in question, No. 9. The main goal was to prevent any disruption to the gate opening through adequate monitoring for a long term data follow-up. Six long-base OSMOS type optical sensors were installed on each face of the spillway pilaster. The behaviour of the No. 9 pilaster was then compared with that of other pilasters with respect to the effects of temperature and water level fluctuation in the dam. After the pilasters had been monitored for six months, it was found that No. 9 pilaster showed the least deformation of all. It was therefore concluded that the behaviour of this pilaster was normal.

English in Economy World: an Overview of English Learning

OpenAIRE

Setyaningsih, Ani; Kurniasih, Siwi Karmadi

2007-01-01

English is not a language for the English-speaking countries anymore. English has spread worldwide to the countries in the five continents. One of the reasons is economy. People need to acquire English since it is one way to cope with the communication in economy trend. English is needed to process information, analyze, evaluate, experiment, negotiate and collaborate in economy. The awareness of English importance in the globalization era has made people learn this universal language consciou...

REMOVAL OF CHEMICAL AND MICROBIAL CONTAMINANTS IN DRINKING WATER - WATTS PREMIER M-2400 POINT-OF-ENTRY REVERSE OSMOSIS DRINKINGWATER TREATMENT SYSTEM

Science.gov (United States)

The Watts Premier M-2400 POE RO Drinking Water Treatment System was tested at the NSF Drinking Water Treatment Systems Laboratory for removal of the viruses fr and MS2, the bacteria Brevundimonas diminuta, and chemicals aldicarb, benzene, cadmium, carbofuran, cesium, chl...

Qualitative Impact Assessment 2010: An Independent Study Conducted by BDRC Continental, Ltd., February-July 2010. Premier League Reading Stars

Science.gov (United States)

National Literacy Trust, 2010

2010-01-01

Premier League Reading Stars (PLRS) is in its eighth year. To complement a pre-post quantitative survey, an impact evidence base was required to inform consideration of continued funding into 2011 and beyond. PLRS is very highly regarded among child participants, parents, and librarians. The structure of the scheme, its basis on football, and the…

pH-sensitive Au–BSA–DOX–FA nanocomposites for combined CT imaging and targeted drug delivery

Directory of Open Access Journals (Sweden)

Huang H

2017-04-01

Full Text Available He Huang,1 Da-Peng Yang,2 Minghuan Liu,2 Xiangsheng Wang,1 Zhiyong Zhang,1 Guangdong Zhou,1 Wei Liu,1 Yilin Cao,1 Wen Jie Zhang,1 Xiansong Wang1 1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, National Tissue Engineering Center of China, Shanghai, 2College of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou, People’s Republic of China Abstract: Albumin-based nanoparticles (NPs as a drug delivery system have attracted much attention owing to their nontoxicity, non-immunogenicity, great stability and ability to bind to many therapeutic drugs. Herein, bovine serum albumin (BSA was utilized as a template to prepare Au–BSA core/shell NPs. The outer layer BSA was subsequently conjugated with cis-aconityl doxorubicin (DOX and folic acid (FA to create Au–BSA–DOX–FA nanocomposites. A list of characterizations was undertaken to identify the successful conjugation of drug molecules and targeted agents. In vitro cytotoxicity using a cell counting kit-8 (CCK-8 assay indicated that Au–BSA NPs did not display obvious cytotoxicity to MGC-803 and GES-1 cells in the concentration range of 0–100 µg/mL, which can therefore be used as a safe drug delivery carrier. Furthermore, compared with free DOX, Au–BSA–DOX–FA nanocomposites exhibited a pH-sensitive drug release ability and superior antitumor activity in a drug concentration-dependent manner. In vivo computed tomography (CT imaging experiments showed that Au–BSA–DOX–FA nanocomposites could be used as an efficient and durable CT contrast agent for targeted CT imaging of the folate receptor (FR overexpressed in cancer tissues. In vivo antitumor experiments demonstrated that Au–BSA–DOX–FA nanocomposites have selective antitumor activity effects on FR-overexpressing tumors and no adverse effects on normal tissues and

HEAT TRANSFER EVALUATION OF HFC-236FA IN CONDENSATION AND EVAPORATION

Science.gov (United States)

The report gives results of an evaluation of the shell-side heat transfer performance of hydrofluorocarbon (HFC)-236fa, which is considered to be a potential substitute for chlorofluorocarbon (CFC)-114 in Navy shipboard chillers, for both conventional finned [1024- and 1575-fpm (...

Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells

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Eun Young Bae

2015-05-01

Full Text Available Endoplasmic reticulum (ER stress is linked with development and maintenance of cancer, and serves as a therapeutic target for treatment of cancer. Verrucarin A, isolated from the broth of Fusarium sp. F060190, showed potential inhibitory activity on tunicamycin-induced ER stress in FaO rat liver cells. In addition, the compound decreased tunicamycin-induced GRP78 promoter activity in a dose dependent manner without inducing significant inhibition of luciferase activity and cell growth for 6 and 12 h. Moreover, the compound decreased the expression of GRP78, CHOP, XBP-1, and suppressed XBP-1, and reduced phosphorylation of IRE1α in FaO rat liver cells. This evidence suggests for the first time that verrucarin A inhibited tunicamycin-induced ER stress in FaO rat liver cells.

Teaching English through English: Proficiency, Pedagogy and Performance

Science.gov (United States)

Richards, Jack C.

2017-01-01

Most of the world's English language teachers speak English as a second or third language rather than as their first language. For many, their level of proficiency in English may not reach benchmarks established by their employers, raising the issue that is the focus of this article, namely, what kind of proficiency in English is necessary to be…

A Decision Support Concept for a construction design project – selecting the type of glass façade

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Franjo Šimić

2017-01-01

Full Text Available The paper describes research into the possibility of developing a concept for supporting decisions in planning construction projects (one of the most important stages of construction project management. The focus is on supporting decisions in selecting the type of and solution for the glass façade in the main design. Materials and types of soluteons for a glass façade were analyzed and alternative solutions were obtained. The concept was developed in that it included relevant stakeholders in the decision-making process during the construction design. These stakeholders were the investor, architect, and construction contractor. The analysis was carried out and a hierarchical structure of objectives was formed as a goal tree. The criteria at the last hierarchical level were used to evaluate alternative solutions for the glass façade, and their weights were determined by all stakeholders using the AHP method (Analytic Hierarchy Process. Using PROMETHEE (Preference Ranking Method for Enrichment Evaluation, a comparison of alternative solutions for the glass façade was conducted and the alternatives were ranked according to the priorities for inclusion into the main design. The concept was tested by selecting a type of glass façade on a residential-commercial building in the city of Rijeka, Croatia.

An enhanced functional ability questionnaire (faVIQ to measure the impact of rehabilitation services on the visually impaired

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James Stuart Wolffsohn

2014-02-01

Full Text Available AIM:To develop a short, enhanced functional ability Quality of Vision (faVIQ instrument based on previous questionnaires employing comprehensive modern statistical techniques to ensure the use of an appropriate response scale, items and scoring of the visual related difficulties experienced by patients with visual impairment.METHODS:Items in current quality-of-life questionnaires for the visually impaired were refined by a multi-professional group and visually impaired focus groups. The resulting 76 items were completed by 293 visually impaired patients with stable vision on two occasions separated by a month. The faVIQ scores of 75 patients with no ocular pathology were compared to 75 age and gender matched patients with visual impairment.RESULTS:Rasch analysis reduced the faVIQ items to 27. Correlation to standard visual metrics was moderate (r=0.32-0.46 and to the NEI-VFQ was 0.48. The faVIQ was able to clearly discriminate between age and gender matched populations with no ocular pathology and visual impairment with an index of 0.983 and 95% sensitivity and 95% specificity using a cut off of 29.CONCLUSION:The faVIQ allows sensitive assessment of quality-of-life in the visually impaired and should support studies which evaluate the effectiveness of low vision rehabilitation services.

Injury profile of a professional soccer team in the premier league of iran.

Science.gov (United States)

Hassabi, Mohammad; Mohammad-Javad Mortazavi, Seyed; Giti, Mohammad-Reza; Hassabi, Majid; Mansournia, Mohammad-Ali; Shapouran, Sara

2010-12-01

Despite numerous studies which have been done regarding soccer injuries worldwide, there is lack of available data considering the epidemiology of injuries in the Iranian soccer premier league, although it is the most popular sport in the country. The main goal of this research was to determine the incidence of physical injuries in the studied population, considering other characteristics such as site, type and mechanism as well. Twenty one adult male professional soccer players (age 24±3), members of a team (Tehran-Pas) participating in Iranian premier league, were followed during a 4-month period. The injury characteristics and exposure times were recorded by the team physician during all the matches and training sessions. The total exposure time was 2610 playing hours (2352 h of training versus 258 h of competition). Eighty six percent of the injuries were acute. Incidence of acute injuries was 16.5 (95% CI: 12-22) per 1000 hours of playing (11.5 per 1000 hrs of training and 62 per 1000 hrs of competition). The most common types of injuries were strains followed by contusions, each of which constituted 30% of acute injuries. More than 80% of injuries occurred in lower limbs, especially in thigh and groin regions. Nearly 60% of acute injuries occurred in dominant side of the body, and collision was the reason of about half of the acute injuries. Severity of more than 70% of the injuries was minor. On average each injury had led the player being off the field for about 10 days. The incidence of injury in this research is in range of numbers obtained in important international tournaments but the rate of injuries during training sessions is higher than comparable studies.

The energy outlook in China-Minutes from the seminar organised by the Centre Geopolitique de l'Energie et des Matieres Premieres

International Nuclear Information System (INIS)

Keppler, J.H.; Meritet, S.

2004-01-01

As part of the seminars that are organised on a regular basis, the Centre de Geopolitique de l'Energie et des Matieres Premieres has devoted, on the 2. of June, a day to China, its energetics outlook and the resulting economic and geopolitical challenges. (authors)

Expansion and characterization of ventral mesencephalic precursor cells: effect of mitogens and investigation of FA1 as a potential dopaminergic marker

DEFF Research Database (Denmark)

Jensen, Pia; Bauer, Matthias; Jensen, Charlotte H

2007-01-01

factor 8 (FGF8) for expansion of such dopaminergic precursor cells, and fetal antigen-1 (FA1), a secreted neuronal protein of unknown function, as a non-invasive dopaminergic marker. Tissue from embryonic day (ED) 12 rat ventral mesencephalon was dissociated mechanically and cultured for 4 days...... to controls. After differentiation, biochemical analyses showed significantly more dopamine and FA1 in conditioned medium from both FGF2 and FGF8 expanded cultures than in controls. Correspondingly, numbers of tyrosine hydroxylase (TH)- and FA1-immunoreactive cells had increased 16-fold (P ... for these cells. Furthermore, FA1 was identified as a potential supplementary non-invasive marker of cultured dopaminergic neurons....

Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation

International Nuclear Information System (INIS)

Petersen, Cordula; Zips, Daniel; Krause, Mechthild; Schoene, Kerstin; Eicheler, Wolfgang; Hoinkis, Cordelia; Thames, Howard D.; Baumann, Michael

2001-01-01

Purpose: FaDu human squamous cell carcinoma (FaDu-hSCC) showed a clear-cut time factor during fractionated radiotherapy (RT) under ambient blood flow. It remained unclear whether this is caused solely by proliferation or if radioresistance resulting from increasing hypoxia contributed to this phenomenon. To address this question, repopulation of clonogenic FaDu cells during fractionated RT under clamp hypoxia was determined by local tumor control assays, and compared to the results after irradiation with the same regimen under ambient blood flow. Methods and Materials: FaDu-hSCC was transplanted into the right hind leg of NMRI nu/nu mice. In the first set of experiments, irradiation was performed under clamp hypoxia. After increasing numbers of 3 Gy fractions (time intervals 24 h or 48 h), graded top-up doses were given to determine the TCD 50 (dose required to control 50% of the tumors). In the second set of experiments, all 3 Gy fractions were applied under ambient conditions, but as in the previous experiments the graded top-up doses were given under clamp hypoxia. A total of 26 TCD 50 assays were performed and analyzed using maximum likelihood techniques. Results: With increasing numbers of daily fractions, the top-up TCD 50 under clamp hypoxia decreased from 39.4 Gy [95% CI 36, 42] after single dose to 19.8 Gy [15, 24] after 18 fractions in 18 days and to 37.8 Gy [31, 44] after 18 fractions in 36 days. The results were consistent with biphasic repopulation, with a switch to rapid repopulation after about 22 days [13, 30]. The clonogen doubling time (T clon ) decreased from 9.8 days [0, 21] in the beginning of RT to 3.4 days after 22 days. Under ambient blood flow the top-up TCD 50 decreased from 37.6 Gy [34, 40] after single dose irradiation to 0 Gy [0, 1] after 18 fractions in 18 days and 22.4 Gy [18, 27] after 18 fractions in 36 days. Similar to results from irradiations under clamp hypoxia, the ambient data were consistent with a biphasic course of clonogen

Buoyancy-Driven Ventilation Generated by the Double-Skin Façade of a High-Rise Building in Tropical Climate: Case Study Bandung, Indonesia

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Aziiz Akhlish Diinal

2017-01-01

Full Text Available High-rise buildings in tropical region is identical to the use of mechanical Air Conditioning in massive scale. Nevertheless, there is an encouragement to high-rise buildings to reduce its energy consumptions, since they consume quite large amount of energy. This challenge can be overcome with various of strategies, one of them, by means of reducing the cooling load of mechanical Air Conditioning in high-rise building. Prospects come from the modern tall building design strategies, for example the use of double-skin façade to give addition of building skin which could provide indoor temperature protection from outside. Double-skin façade system has continued to increase in buildings in a tropical region such as in Indonesia. However, there is another potential of double skin façade, which is the possibility to increase the buoyancy effect in the air gap between the skin and building envelope. The possibility needs to be studied in order to give a proper way in designing double-skin façade of a high-rise building, especially on Bandung-Indonesia tropical climate. This paper explores the potential of double-skin façade in driving the air inside the façade to generate natural ventilation for a high-rise building in Bandung climate condition. Two parameters are used in exploring the buoyancy force, the width of double-skin façade and the temperature of the skin façade. In general, double-skin façade of a high-rise building in tropical climate can generate buoyancy driven ventilation for the building, it relates strongly to the distance between of the double-skin façade and the building envelope.

Data of evolutionary structure change: 1A4FA-2ZLWD [Confc[Archive

Lifescience Database Archive (English)

Full Text Available 1A4FA-2ZLWD 1A4F 2ZLW A D -VLSAADKTNVKGVFSKISGHAEEYGAETLERMFTAYPQ...R VQLSGEEKAAVLALWDKV--NEEEVGGEALGRLLVVYPWTQRFFDSFGDLSNPGAVMGNPKVKAHGKKVLHSFGEGVHHLDNLKGTFAALSEL... 2ZLW D 2ZLWD LWDKV--

Design of MiSolFA Hard X-Ray Imager

Science.gov (United States)

Lastufka, Erica; Casadei, Diego

2017-08-01

Advances in the study of coronal electron-accelerating regions have so far been limited by the dynamic range of X-ray instruments. A quick and economical alternative to desirable focusing optics technology is stereo observation. The micro-satellite MiSolFA (Micro Solar-Flare Apparatus) is designed both as a stand-alone X-ray imaging spectrometer and a complement to the Spectrometer/Telescope for Imaging X-rays (STIX) mission. These instruments will be the first pair of cross-calibrated X-ray imaging spectrometers to look at solar flares from very different points of view. MiSolFA will achieve indirect imaging between 10 and 60 keV and provide spectroscopy up to 100 keV, equipped with grids producing moiré patterns in a similar way to STIX. New manufacturing techniques produce gold gratings on a graphite or silicon substrate, with periods ranging from 15 to 225 micrometers, separated by a distance of 15.47 cm, to achieve a spatial resolutions from 10" to 60" (as compared to RHESSI's separation of 150 cm and 1" resolution). We present the progress of the imager design, the performance of the first prototypes, and reach out to the community for further scientific objectives to consider in optimizing the final design.

Delta-like 1/Fetal Antigen-1 (Dlk1/FA1) Is a Novel Regulator of Chondrogenic Cell Differentiation via Inhibition of the Akt Kinase-dependent Pathway*

Science.gov (United States)

Chen, Li; Qanie, Diyako; Jafari, Abbas; Taipaleenmaki, Hanna; Jensen, Charlotte H.; Säämänen, Anna-Marja; Sanz, Maria Luisa Nueda; Laborda, Jorge; Abdallah, Basem M.; Kassem, Moustapha

2011-01-01

Delta-like 1 (Dlk1, also known as fetal antigen-1, FA1) is a member of Notch/Delta family that inhibits adipocyte and osteoblast differentiation; however, its role in chondrogenesis is still not clear. Thus, we overexpressed Dlk1/FA1 in mouse embryonic ATDC5 cells and tested its effects on chondrogenic differentiation. Dlk1/FA1 inhibited insulin-induced chondrogenic differentiation as evidenced by reduction of cartilage nodule formation and gene expression of aggrecan, collagen Type II and X. Similar effects were obtained either by using Dlk1/FA1-conditioned medium or by addition of a purified, secreted, form of Dlk1 (FA1) directly to the induction medium. The inhibitory effects of Dlk1/FA1 were dose-dependent and occurred irrespective of the chondrogenic differentiation stage: proliferation, differentiation, maturation, or hypertrophic conversion. Overexpression or addition of the Dlk1/FA1 protein to the medium strongly inhibited the activation of Akt, but not the ERK1/2, or p38 MAPK pathways, and the inhibition of Akt by Dlk1/FA1 was mediated through PI3K activation. Interestingly, inhibition of fibronectin expression by siRNA rescued the Dlk1/FA1-mediated inhibition of Akt, suggesting interaction of Dlk1/FA1 and fibronectin in chondrogenic cells. Our results identify Dlk1/FA1 as a novel regulator of chondrogenesis and suggest Dlk1/FA1 acts as an inhibitor of the PI3K/Akt pathways that leads to its inhibitory effects on chondrogenesis. PMID:21724852

HOW TO MOTIVATE NON-ENGLISH MAJORS TO MASTER ENGLISH

Institute of Scientific and Technical Information of China (English)

1999-01-01

This paper analyses the factors causing the lack of learning motivation of non-English majors,re-garded as one of the crucial reasons leading to the inefficiency of college English teaching in Chi-na.It also puts forward corresponding ways to motivate non-English majors to study English.

English Language Teaching Through Literature : An Application of English Poetry in the High School English Textbook to the Classroom

OpenAIRE

濵口, 脩

2004-01-01

The aim of this present paper is to review the present state of English poetry in the high school English textbooks in Japan and to propose some practical application of English poems to the English language classroom. Several cases in which English poems are found in actual English high school textbooks are discussed, and then, since there seems to be no explanation of teaching English poems, with some notes of them and of reading English poems in general, some practical suggetions for impro...

English Learners: Reaching the Highest Level of English Literacy.

Science.gov (United States)

Garcia, Gilbert C., Ed.

This collection of papers examines the critical literacy development of English learners, focusing on English reading instruction in an immersion setting, English language development, and cultural issues pertaining to English learners in and out of the classroom. The 16 papers include the following: (1) "Reading and the Bilingual Student: Fact…

Delta-like 1/fetal antigen 1(DLK1/FA1) inhibits BMP2 induced osteoblast differentiation through modulation of NFκB signaling pathway

DEFF Research Database (Denmark)

Qiu, Weimin; Abdallah, Basem; Kassem, Moustapha

DLK1/FA1 (delta-like 1/fetal antigen-1) is a negative regulator of bone mass that acts to inhibit osteoblast differentiation and stimulate osteoclast differentiation. However, the molecular mechanisms underlying these effects are not known. Thus, we studied the effect of DLK1/FA1 on different...... osteogenic factors-induced osteoblast differentiation. We identified DLK1/FA1 as an inhibitor of BMP2-induced osteogenesis in mouse myoblast C2C12 cells. Stable overexpression of DLK1/FA1 in C2C12 cells or the addition of its soluble form protein FA1 significantly inhibited BMP2-induced osteogenesis...... as assessed by reduced Alp activity and osteogenic gene expression including Alp, Col1a1, Runx2 and Bglap. In addition, DLK1/FA1 inhibited BMP signaling as demonstrated by reduced gene expression of BMP-responsive genes: Junb and Id1, reduced BMP2 induced luciferase activity in C2C12 BMP luciferase reporter...

Transport and fate of Herbaspirillum chlorophenolicum FA1 in saturated porous media

Science.gov (United States)

Li, X.; Xu, H.; Wu, J.

2016-12-01

For the bioremediation of contaminated groundwater, sufficient dispersal of functional microorganisms is one of the most important factors that determine the remediation efficiency. There are extensive studies on the transport of microbes in porous media, while most of them focus on pathogenic bacteria and little attention has been given toward functional bacteria that being used in bioremediation process. Therefore, accurate knowledge of the mechanisms that govern the transport and distribution of such bacteria in groundwater is needed to develop efficient treatment techniques. Herbaspirillum chlorophenolicum FA1, a pure bacterial strain capable of absorbing heavy metals and degrading polycyclic aromatic hydrocarbons (PAHs), was selected as the representative functional bacterium in this study. A series of batch and column experiments were conducted to investigate the transport and deposition behavior of strain FA1 in saturated porous media. The effects of physical (grain size), chemical (ionic strength, humic acid), and biological factors (living/dead cells) were studied in detail. In addition, numerical simulations of breakthrough curve (BTC) data were also performed for information gathering. Results of this study could advance our understanding of functional bacteria transport and help to develop successful bioremediation strategies. This work was financially supported by the National Natural Science Foundation of China -Xinjiang Project (U1503282), the National Natural Science Foundation of China (41030746, 41102148), and the Natural Science Foundation of Jiangsu Province (BK20151385). Keywords: Herbaspirillum chlorophenolicum FA1, bacteria, porous media, transport, modeling

Experimental verification of FA for WWER-1000. Investigations of TVS - 2M

International Nuclear Information System (INIS)

Vasilchenko, I.; Seleznev, A.; Kobelev, S.; Makarov, V.; Afanasjev, A.; Matvienko, I.; Enin, A.; Ustimenko, A.; Volkov, S.

2008-01-01

During development of TVS-2M design for WWER-1000 and within the scope of its pre-reactor verification there was performed a complex of bench tests of FA for operational impacts. These tests were carried out with the use of the full-scale non-irradiated FA dummy and the models of units. The present report presents the methods and the results of tests of the full-scale dummy for static concentrated loads, impact of thermal cycling and vibration under separate and simultaneous impact of the listed loads. The results of tests carried out indicate that the solutions implemented in TVS-2M, first of all, a rigid welded skeleton, provide much higher resistance to distortion due to thermomechanical loads in comparison with zirconium AFA of the previous generation. This work was organized by JSC TVEL. (authors)

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, REMOVAL OF ARSENIC IN DRINKING WATER: WATTS PREMIER M-SERIES M-15,000 REVERSE OSMOSIS TREATMENT SYSTEM

Science.gov (United States)

Verification testing of the Watts Premier M-Series M-15,000 RO Treatment System was conducted over a 31-day period from April 26, 2004, through May 26, 2004. This test was conducted at the Coachella Valley Water District (CVWD) Well 7802 in Thermal, California. The source water...

FA composition of heart and skeletal muscle during embryonic development of the king penguin.

Science.gov (United States)

Decrock, Frederic; Groscolas, Rene; Speake, Brian K

2002-04-01

Since the yolk lipids of the king penguin (Aptenodytes patagonicus) naturally contain the highest concentrations of DHA and EPA yet reported for the eggs of any avian species, the effects of this (n-3)-rich yolk on the FA profiles of the embryonic heart and skeletal muscle were investigated. The concentrations (mg/g wet tissue) of phospholipid (PL) in the developing heart and leg muscle of the penguin doubled between days 27 and 55 from the beginning of egg incubation (i.e., from the halfway stage of embryonic development to 2 d posthatch), whereas no net increase occurred in pectoral muscle. During this period, the concentration of TAG in heart decreased by half but increased two- and sixfold in leg and pectoral muscle, respectively. The most notable change in cholesteryl ester concentration occurred in pectoral muscle, increasing ninefold between days 27 and 55. Arachidonic acid (ARA) was the major polyunsaturate in PL of the penguin's heart, where it formed about 20% (w/w) of FA at day 55. At the equivalent developmental stage, the heart PL of the chicken contained a 1.3-fold greater proportion of ARA, contained a fifth less DHA, and was almost devoid of EPA, whereas the latter FA was a significant component (7% of FA) of penguin heart PL. Similarly, in PL of leg and pectoral muscle, the chicken displayed about 1.4-fold more ARA, up to 50% less DHA, and far less EPA in comparison with the penguin. Thus, although ARA-rich PL profiles are achieved in the heart and muscle of the penguin embryo, these profiles are significantly affected by the high n-3 content of the yolk.

Viewing time measures of sexual orientation in Samoan cisgender men who engage in sexual interactions with fa'afafine.

Science.gov (United States)

Petterson, Lanna J; Dixson, Barnaby J; Little, Anthony C; Vasey, Paul L

2015-01-01

Androphilia refers to attraction to adult males, whereas gynephilia refers to attraction to adult females. The current study employed self-report and viewing time (response time latency) measures of sexual attraction to determine the sexual orientation of Samoan cisgender men (i.e., males whose gender presentation and identity is concordant with their biological sex) who engage in sexual interactions with transgender male androphiles (known locally as fa'afafine) compared to: (1) Samoan cisgender men who only engage in sexual interactions with women, and (2) fa'afafine. As expected, both measures indicated that cisgender men who only engaged in sexual interactions with women exhibited a gynephilic pattern of sexual attraction, whereas fa'afafine exhibited an androphilic one. In contrast, both measures indicated that cisgender men who engaged in sexual interactions with fa'afafine demonstrated a bisexual pattern of sexual attraction. Most of the cisgender men who exhibited bisexual viewing times did not engage in sexual activity with both men and women indicating that the manner in which bisexual patterns of sexual attraction manifest behaviorally vary from one culture to the next.

Viewing time measures of sexual orientation in Samoan cisgender men who engage in sexual interactions with fa'afafine.

Directory of Open Access Journals (Sweden)

Lanna J Petterson

Full Text Available Androphilia refers to attraction to adult males, whereas gynephilia refers to attraction to adult females. The current study employed self-report and viewing time (response time latency measures of sexual attraction to determine the sexual orientation of Samoan cisgender men (i.e., males whose gender presentation and identity is concordant with their biological sex who engage in sexual interactions with transgender male androphiles (known locally as fa'afafine compared to: (1 Samoan cisgender men who only engage in sexual interactions with women, and (2 fa'afafine. As expected, both measures indicated that cisgender men who only engaged in sexual interactions with women exhibited a gynephilic pattern of sexual attraction, whereas fa'afafine exhibited an androphilic one. In contrast, both measures indicated that cisgender men who engaged in sexual interactions with fa'afafine demonstrated a bisexual pattern of sexual attraction. Most of the cisgender men who exhibited bisexual viewing times did not engage in sexual activity with both men and women indicating that the manner in which bisexual patterns of sexual attraction manifest behaviorally vary from one culture to the next.

Polychromie et représentations apotropaïques sur la façade de l'église du Saint-sauveur a Žiča

Directory of Open Access Journals (Sweden)

Čanak-Medić Milka

2006-01-01

Full Text Available (francuski Seules les descriptions de l'aspect extérieur de l'église de l'Ascension du Christ a Decani recourent a des termes aussi élogieux que ceux employés roi parler de l'église du Saint-Sauveur a Žiča. Et, de fait, La beauté de cette dernière a notamment été tout particulièrement soulignée par les anciens écrivains, Domentijan et Teodosije. Tout le sens de leurs paroles n'a toutefois été perf qu'a la suite de récents travaux de restauration entrepris sur l'église s'étant soldes par le dégagement de restes de couches de peinture recouvrant ses murs extérieurs et ayant, de ce fait, permis d'entrevoir l'aspect originel de la décoration poly chromatique extérieur de l'église. Les premières connaissances concernant la décoration des façades de l'église de Žiča remontent aux années vingt du XXe siècle. On a alors dégage deux couches dont la plus récente a été datée de la quatrième décennie du XIV femme siècle (fig. 3, 4 alors qu'a plusieurs endroits a été constatée au-dessous de celle-ci, la couche de crépis originelle. Celle-ci recouvrait toutes les surfaces des murs a 1'exception des corniches, des frises des arcades et, vraisemblablement, des cadres des fenêtres (fig. 5, 6. La datation exacte de cette couche inferieure de crépis a été possible grâce aux résultats de sondages effectues a la jonction des portiques précédant les par églises et, respectivement, des murs sud et nord de 1'exonarthex, ériges au plus tard en 1230. Sur la partie frontale du mur du portique précédent la par église sud dédiée au saint premier martyr Etienne subsiste les restes d'une croix ornee de pierres précieuses: creux gem mata, d'une grande taille au-dessus de laquelle apparait la partie inferieure d'une figure de saint (fig. 1, 7, 8, 10 alors que sur la façade du portique nord on relève les traces d'une composition historiée non identifiable (fig. 12. II est donne question d'une trouvaille fermée dont

Consumption of fa cai Nostoc soup: a potential for BMAA exposure from Nostoc cyanobacteria in China?

Science.gov (United States)

Roney, Britton R; Renhui, Li; Banack, Sandra Anne; Murch, Susan; Honegger, Rosmarie; Cox, Paul Alan

2009-01-01

Grown in arid regions of western China the cyanobacterium Nostoc flagelliforme--called fa cai in Mandarin and fat choy in Cantonese--is wild-harvested and used to make soup consumed during New Year's celebrations. High prices, up to $125 USD/kg, led to overharvesting in Inner Mongolia, Ningxia, Gansu, Qinghai, and Xinjiang. Degradation of arid ecosystems, desertification, and conflicts between Nostoc harvesters and Mongol herdsmen concerned the Chinese environmental authorities, leading to a government ban of Nostoc commerce. This ban stimulated increased marketing of a substitute made from starch. We analysed samples purchased throughout China as well as in Chinese markets in the United States and the United Kingdom. Some were counterfeits consisting of dyed starch noodles. A few samples from California contained Nostoc flagelliforme but were adulterated with starch noodles. Other samples, including those from the United Kingdom, consisted of pure Nostoc flagelliforme. A recent survey of markets in Cheng Du showed no real Nostoc flagelliforme to be marketed. Real and artificial fa cai differ in the presence of beta-N-methylamino-L-alanine (BMAA). Given its status as a high-priced luxury food, the government ban on collection and marketing, and the replacement of real fa cai with starch substitutes consumed only on special occasions, it is anticipated that dietary exposure to BMAA from fa cai will be reduced in the future in China.

Prismatic louver active façades for natural illumination and thermal energy gain in high-rise and commercial buildings

Science.gov (United States)

Vlachokostas, A.; Volkmann, C.; Madamopoulos, N.

2013-06-01

High-rise and commercial buildings in urban centers present a great challenge in terms of their energy consumption. Due to maximization of rentable square footage, the preferred urban façade system over the past 50 years has been the "curtain wall", only a few inches thick and comprised of modular steel or aluminum framing and predominant glass infills. The perceived Achilles heel of these modern glass façade systems is their thermal inefficiency: They are inadequate thermal barriers and exhibit excessive solar gain. The excessive solar gain has a negative impact on lighting and cooling loads of the entire building. This negative impact will be further exacerbated with rising energy costs. However, rather than view the glass façade's uncontrolled solar gain merely as a weakness contributing to higher energy consumption, the condition could indeed be considered as related to an energy solution. These glass façades can be retrofitted to operate as a provider of daylight and energy for the rest of the building, taking advantage of the overexposure to the sun. With today's technology, the sun's abundant renewable energy can be the driving force for the energy transition of these building envelopes. Illumination, thermal energy, and electricity production can be directly supplied from the sun, and when correctly and efficiently managed, they can lead to a significantly less energy-intensive building stock. We propose a multi-purpose, prismatic, louver-based façade to perform both daylight and thermal energy harvesting with a goal of offering a better daylight environment for the occupants, and reduce the energy consumption and carbon footprint of the building. While decentralized air-conditioning units are commonly accepted as façade "plug-ins", such decentralization could be utilized with more benefits by passively managing the interior space conditions, without using any extra power. Just as living organisms respond and adapt to the environmental changes in

Wind tunnel study of natural ventilation of building integrated photovoltaics double skin façade

Science.gov (United States)

Hudişteanu, Sebastian Valeriu; Popovici, Cătălin George; Cherecheş, Nelu-Cristian

2018-02-01

The paper presents a wind tunnel experimental analysis of a small-scale building model (1:30). The objective of the study is to determine the wind influence on the ventilation of a double skin façade channel (DSF) and the cooling effect over integrated photovoltaic panels. The tests were achieved by conceiving and implementation of an experimental program using a wind tunnel with atmospheric boundary layer. The effect of the wind over the ventilation of the horizontal channels of double skin façades is evaluated for different incident velocities. The results are generalized for the average steady state values of the velocities analysed. The experimental results put in evidence the correlation between the reference wind velocity and the dynamics of the air movement inside the double skin façade. These values are used to determine the convective heat transfer and the cooling effect of the air streams inside the channel upon the integrated photovoltaic panels. The decrease of the photovoltaic panels temperature determines a raise of 11% in efficiency and power generated.

Wind tunnel study of natural ventilation of building integrated photovoltaics double skin façade

Directory of Open Access Journals (Sweden)

Hudişteanu Sebastian Valeriu

2018-01-01

Full Text Available The paper presents a wind tunnel experimental analysis of a small-scale building model (1:30. The objective of the study is to determine the wind influence on the ventilation of a double skin façade channel (DSF and the cooling effect over integrated photovoltaic panels. The tests were achieved by conceiving and implementation of an experimental program using a wind tunnel with atmospheric boundary layer. The effect of the wind over the ventilation of the horizontal channels of double skin façades is evaluated for different incident velocities. The results are generalized for the average steady state values of the velocities analysed. The experimental results put in evidence the correlation between the reference wind velocity and the dynamics of the air movement inside the double skin façade. These values are used to determine the convective heat transfer and the cooling effect of the air streams inside the channel upon the integrated photovoltaic panels. The decrease of the photovoltaic panels temperature determines a raise of 11% in efficiency and power generated.

Systems of Vegetal Façade and Green Roofs used as a Sustainable Option in Architecture

OpenAIRE

Chanampa, Mariana; Vidal Rivas, Pilar; Alonso Ojembarrena, Javier; Olivieri, Francesca

2010-01-01

Green architecture contributes not only in reducing the building’s thermal loads but also in reducing the effects of the urban heat island in densely built-up areas in a hardly natural environment. The current green systems are built in situ/on site and are very expensive, hence the need to create industrialized prevegetated systems which improve the buildings’ energy savings and reduce the times of construction works. The present paper describes three green systems for façades (gabion façade...

Radiological English

Energy Technology Data Exchange (ETDEWEB)

Ribes, R. [Hospital Reina Sofia, Cordoba (Spain). Servicio de Radiologia; Ros, P.R. [Harvard Medical School, Boston, MA (United States). Div. of Radiology

2007-07-01

The book is an introductory book to radiological English on the basis that there are a lot of radiologists, radiology residents, radiology nurses, radiology students, and radiographers worldwide whose English level is indeterminate because their reading skills are much higher than their fluency. It is intended to help those health care professionals who need English for their work but do not speak English on a day-to-day basis. (orig.)

Radiological English

International Nuclear Information System (INIS)

Ribes, R.; Ros, P.R.

2007-01-01

The book is an introductory book to radiological English on the basis that there are a lot of radiologists, radiology residents, radiology nurses, radiology students, and radiographers worldwide whose English level is indeterminate because their reading skills are much higher than their fluency. It is intended to help those health care professionals who need English for their work but do not speak English on a day-to-day basis. (orig.)

ECCS analysis of B and W's 177-FA lowered-loop NSS

International Nuclear Information System (INIS)

Jones, R.C.; Biller, J.R.; Dunn, B.M.

1975-06-01

The effectiveness for the ECCS for B and W's 177-FA Lowered-Loop NSS is shown to meet the five criteria of 10 CFR 50.46. A spectrum analysis is performed and the worst case is used to establish allowable linear heat rates as a function of elevation in the core. (U.S.)

Learning Strategies in Alleviating English Writing Anxiety for English Language Learners (ELLs) with Limited English Proficiency (LEP)

Science.gov (United States)

Wu, Chia-Pei; Lin, Huey-Ju

2016-01-01

This study utilized the Oxford Strategy Inventory for Language Learning (SILL) and an English writing anxiety scale to examine the relationship between learning strategies and English writing anxiety in 102 university-level English language learners (ELLs) with Limited English Proficiency (LEP) in a university in Taiwan. Kruskal Wallis Test…

Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway

DEFF Research Database (Denmark)

Chen, Li; Qanie, Diyako; Jafari, Abbas

2011-01-01

Delta-like 1 (Dlk1, also known as fetal antigen-1, FA1) is a member of Notch/Delta family that inhibits adipocyte and osteoblast differentiation; however, its role in chondrogenesis is still not clear. Thus, we overexpressed Dlk1/FA1 in mouse embryonic ATDC5 cells and tested its effects...... on chondrogenic differentiation. Dlk1/FA1 inhibited insulin-induced chondrogenic differentiation as evidenced by reduction of cartilage nodule formation and gene expression of aggrecan, collagen Type II and X. Similar effects were obtained either by using Dlk1/FA1-conditioned medium or by addition of a purified......, secreted, form of Dlk1 (FA1) directly to the induction medium. The inhibitory effects of Dlk1/FA1 were dose-dependent and occurred irrespective of the chondrogenic differentiation stage: proliferation, differentiation, maturation, or hypertrophic conversion. Overexpression or addition of the Dlk1/FA1...

Adaptive Augmenting Control Flight Characterization Experiment on an F/A-18

Science.gov (United States)

VanZwieten, Tannen S.; Orr, Jeb S.; Wall, John H.; Gilligan, Eric T.

2014-01-01

This paper summarizes the Adaptive Augmenting Control (AAC) flight characterization experiments performed using an F/A-18 (TN 853). AAC was designed and developed specifically for launch vehicles, and is currently part of the baseline autopilot design for NASA's Space Launch System (SLS). The scope covered here includes a brief overview of the algorithm (covered in more detail elsewhere), motivation and benefits of flight testing, top-level SLS flight test objectives, applicability of the F/A-18 as a platform for testing a launch vehicle control design, test cases designed to fully vet the AAC algorithm, flight test results, and conclusions regarding the functionality of AAC. The AAC algorithm developed at Marshall Space Flight Center is a forward loop gain multiplicative adaptive algorithm that modifies the total attitude control system gain in response to sensed model errors or undesirable parasitic mode resonances. The AAC algorithm provides the capability to improve or decrease performance by balancing attitude tracking with the mitigation of parasitic dynamics, such as control-structure interaction or servo-actuator limit cycles. In the case of the latter, if unmodeled or mismodeled parasitic dynamics are present that would otherwise result in a closed-loop instability or near instability, the adaptive controller decreases the total loop gain to reduce the interaction between these dynamics and the controller. This is in contrast to traditional adaptive control logic, which focuses on improving performance by increasing gain. The computationally simple AAC attitude control algorithm has stability properties that are reconcilable in the context of classical frequency-domain criteria (i.e., gain and phase margin). The algorithm assumes that the baseline attitude control design is well-tuned for a nominal trajectory and is designed to adapt only when necessary. Furthermore, the adaptation is attracted to the nominal design and adapts only on an as-needed basis

English in Africa

African Journals Online (AJOL)

English in Africa was founded in 1974 to provide a forum for the study of African literature and English as a language of Africa. The Editor invites contributions, including unsolicited reviews, on all aspects of English writing and the English language in Africa, including oral traditions. English in Africa is listed in the Journal of ...

Isolation and differentiation of chondrocytic cells derived from human embryonic stem cells using dlk1/FA1 as a novel surface marker

DEFF Research Database (Denmark)

Harkness, Linda; Taipaleenmaki, Hanna; Mahmood, Amer

2009-01-01

of dlk1/FA1 as a novel surface marker for chondroprogenitor cells during hESC differentiation. We found that, Dlk1/FA1 is expressed specifically in cells undergoing transition from proliferating to prehypertrophic chondrocytes during endochondral ossification of the mouse limb. In hESC cells, dlk1/FA1...... was not expressed by undifferentiated hESC, but expressed during in vitro embryoid bodies (hEBs) formation upon down-regulation of undifferentiated markers e.g. Oct 3/4. Similarly, dlk1/FA1 was expressed in chondrocytic cells during in vivo teratoma formation. Interestingly, treatment of hEBs with Activin B......, a member of TGF-ss family, markedly increased Dlk1 expression in association with up-regulation of the mesoderm-specific markers (e.g. FOXF1, KDR and VE-cadherin) and SOX9. dlk1/FA1(+) cells isolated by fluorescence activated cell sorting (FACS) were capable of differentiating into chondrocytic cells when...

Data of evolutionary structure change: 1J3FA-1LHSA [Confc[Archive

Lifescience Database Archive (English)

Full Text Available 1J3FA-1LHSA 1J3F 1LHS A A MVLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPE...TLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTGLGAILKKKGHHEAELKPLAQSHAT--KIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKY...line>ILE CA 332 LYS CA 290 1LHS A 1LHSA ESHATKHKIPVK HH

7 CFR 247.13 - Provisions for non-English or limited-English speakers.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false Provisions for non-English or limited-English speakers... § 247.13 Provisions for non-English or limited-English speakers. (a) What must State and local agencies do to ensure that non-English or limited-English speaking persons are aware of their rights and...

Development and Characterization of a High Sensitivity Segmented Fast Neutron Spectrometer (FaNS-2).

Science.gov (United States)

Langford, T J; Beise, E J; Breuer, H; Heimbach, C R; Ji, G; Nico, J S

2016-01-01

We present the development of a segmented fast neutron spectrometer (FaNS-2) based upon plastic scintillator and 3 He proportional counters. It was designed to measure both the flux and spectrum of fast neutrons in the energy range of few MeV to 1 GeV. FaNS-2 utilizes capture-gated spectroscopy to identify neutron events and reject backgrounds. Neutrons deposit energy in the plastic scintillator before capturing on a 3 He nucleus in the proportional counters. Segmentation improves neutron energy reconstruction while the large volume of scintillator increases sensitivity to low neutron fluxes. A main goal of its design is to study comparatively low neutron fluxes, such as cosmogenic neutrons at the Earth's surface, in an underground environment, or from low-activity neutron sources. In this paper, we present details of its design and construction as well as its characterization with a calibrated 252 Cf source and monoenergetic neutron fields of 2.5 MeV and 14 MeV. Detected monoenergetic neutron spectra are unfolded using a Singular Value Decomposition method, demonstrating a 5% energy resolution at 14 MeV. Finally, we discuss plans for measuring the surface and underground cosmogenic neutron spectra with FaNS-2.

A Non-Ventilated Solar Façade Concept Based on Selective and Transparent Insulation Material Integration: An Experimental Study

Directory of Open Access Journals (Sweden)

Miroslav Čekon

2017-06-01

Full Text Available A new solar façade concept based on transparent insulation and a selective absorber is proposed, tested and compared with conventional insulation and a non-selective type of absorber, respectively. The presented study focuses on an experimental non-ventilated solar type of façade exposed to solar radiation both in the laboratory and in outdoor tests. Due to the high solar absorbance level of the façade, high- and low-emissivity contributions were primarily analysed. All of the implemented materials were contrasted from the thermal and optical point of view. An analysis was made of both thermodynamic and steady state procedures affecting the proposed solar façade concept. Experimental full scale tests on real building components were additionally involved during summer monitoring. An indicator of the temperature response generated by solar radiation exposure demonstrates the outdoor performance of the façade is closely related to overheating phenomena. From the thermal point of view, the proposed transparent insulation and selective absorber concept corresponds to the performance of conventional thermal insulation of identical material thickness; however, the non-selective prototype only provides 50% thermal performance. The results of the solar-based experiments show that with a small-scale experimental prototype, approximately no significant difference is measured when compared with a non-selective absorber type. The only difference was achieved at the maximum of 2.5 K, when the lower temperature was obtained in the solar selective concept. At the full-scale outdoor mode, the results indicate a maximum of 3.0 K difference, however the lower temperature achieves a non-selective approach. This solar façade can actively contribute to the thermal performance of building components during periods of heating.

What is English?

Directory of Open Access Journals (Sweden)

Ulrikke Rindal

2014-10-01

Full Text Available This article considers the developing status of English in Norway, both as a language and as a school subject, making predictions about which ontological and epistemological perspectives will influence English language teaching (ELT in Norway towards 2030. Status quo and predictions for English in Norway is approached from two angles; the development of presiding language beliefs in linguistic science and in ELT practices from the 16th century to the present, and the more recent and rapid development of English as the foremost global language of communication. The article shows how English language beliefs and the status of English are made visible in the national subject curriculum and in the English language practices among Norwegian adolescent learners. The discussion suggests that English is increasingly characterised by those who use it as a second or later language, including Norwegians who negotiate the meanings of English in the ELT classroom. The article predicts that a logical development for Norwegian ELT is increased influence from social constructionist perspectives, in combination with the existing focus on communicative competence. The study shows that global circumstances related to the status of English are reciprocally related to local language beliefs among educational authorities, teachers and students, and that these have major implications for English as a discipline in lower and higher education.

Learner Views on English and English Language Teaching in China

Science.gov (United States)

Liu, Na; Lin, Chih-Kai; Wiley, Terrence G.

2016-01-01

Since the 1980s, China has represented one of the major growth areas in the world for English language education, and studying English has been a priority among its foreign language educational policies. As English has gained more popularity in China, some have noted the potential value of English as a means to greater educational access and…

Introducing Business English

NARCIS (Netherlands)

Nickerson, C.; Planken, B.C.

2015-01-01

Introducing Business English provides a comprehensive overview of this topic, situating the concepts of Business English and English for Specific Business Purposes within the wider field of English for Special Purposes. This book draws on contemporary teaching and research contexts to demonstrate

Transparent Façade Panel Typologies Based on Recyclable Polymer Materials

Directory of Open Access Journals (Sweden)

Harry Giles

2012-11-01

Full Text Available Buildings are large consumers of energy. In the United States of America; they constitute over 33% of the total annual energy consumption, produce 35% of the total carbon dioxide emissions and attribute 40% of landfill wastes. The building industry is also a large consumer of non-renewable materials and this trend has escalated dramatically over the past century. It is essential that we find ways to save on energy consumption through the use of solar energy, improved thermal insulation, and alternative efficient glazed façade systems. In this paper, we demonstrate how alternative typologies of transparent and translucent load-bearing façade systems based on biocomposite and recyclable materials, are structurally and thermally efficient at the same time they contribute towards reduced pollutant emissions and non-renewable material uses.Composite insulated panel systems are used extensively in the engineering and building industry, owing to their structural and thermal efficiency. However, these systems are generally opaque and offer little flexibility in building applications. As an alternative, we demonstrate how building products comprised of hybrid material typologie scan be made to perform efficiently as load-bearing façade systems that substitute for current glazing systems with adequate thermal and structural performance, which also possess good light transmission characteristics and integral shading capability. The materials are configured to work as composite panel systems made from a combination of biocomposite and recyclable polymer materials. These materials are environmentally sustainable, because they either originate from naturally grown renewable resources or are recyclable. Our research program includes the design and development of prototype panel systems; the evaluation of structural and thermal performance, together with their role in reducing energy consumption and pollution emission through life cycle analysis. The paper

Earphone English.

Science.gov (United States)

Goldsmith, Francisca

2002-01-01

Describes Earphone English, a student club sponsored through a partnership between Berkeley High School and the Berkeley Public Library that offers students whose primary language is not English to practice their spoken and aural English skills. Discusses the audiobooks used in the program and the importance of multicultural content and age…

Constructing English as a Ugandan Language through an English Textbook

Science.gov (United States)

Stranger-Johannessen, Espen

2015-01-01

English is a national language in Uganda and is widely used in elite areas such as politics and business, but most Ugandans master English to only a limited degree. In this situation, English can be seen as either a foreign language or a second language--influencing how English is taught. One goal of language teaching espoused in this article is…

Practices That Promote English Reading for English Learners (Els)

Science.gov (United States)

Martínez, Rebecca S.; Harris, Bryn; McClain, Maryellen Brunson

2014-01-01

Schools are becoming increasingly diversified; however, training and professional development related to working with English language learners (ELs), especially in the area of English reading, is limited. In this article, we identify three "Big Ideas" of effective and collaborative practices that promote English reading achievement for…

Design of an effective bifunctional catalyst organotriphosphonic acid-functionalized ferric alginate (ATMP-FA) and optimization by Box-Behnken model for biodiesel esterification synthesis of oleic acid over ATMP-FA.

Science.gov (United States)

Liu, Wei; Yin, Ping; Liu, Xiguang; Qu, Rongjun

2014-12-01

Biodiesel production has become an intense research area because of rapidly depleting energy reserves and increasing petroleum prices together with environmental concerns. This paper focused on the optimization of the catalytic performance in the esterification reaction of oleic acid for biodiesel production over the bifunctional catalyst organotriphosphonic acid-functionalized ferric alginate ATMP-FA. The reaction parameters including catalyst amount, ethanol to oleic acid molar ratio and reaction temperature have been optimized by response surface methodology (RSM) using the Box-Behnken model. It was found that the reaction temperature was the most significant factor, and the best conversion ratio of oleic acid could reach 93.17% under the reaction conditions with 9.53% of catalyst amount and 8.62:1 of ethanol to oleic acid molar ratio at 91.0 °C. The research results show that two catalytic species could work cooperatively to promote the esterification reaction, and the bifunctional ATMP-FA is a potential catalyst for biodiesel production. Copyright © 2014 Elsevier Ltd. All rights reserved.

Thermal surface analysis on high-rise building façades with neo-minimalist and modern style in Penang, Malaysia

Science.gov (United States)

Arab, Yasser; Hassan, Ahmad Sanusi; Qanaa, Bushra

2017-10-01

This research analyzed the façade thermal performance of high-rise buildings with modern and neo-minimalist architectural style. Four high-rise apartment buildings in Penang Island are selected as case studies for this research. The modern architectural style, which was popular during the 1970s to 1990s, nearly disregarded the cultural identity of the country and used the basic geometric shapes in the design. Conversely, the neo-minimalist style is the popular style from the 2010s up to the present. This style is a result of the "less is more" concept, which means using minimal applications to obtain an efficient design. The four selected case studies are as follows: Halaman Kristal 2 and Mutiara Idaman 1 with modern architectural style and Light Linear and Baystar apartments with neo-minimalist style. The research uses Fluke Ti20 thermal imager to capture thermal images of the west façade of the selected case studies on an hourly basis from 12:00 to 6:00 P.M. on March 15, 2017. Results confirm that the neo-minimalist façade elements, such as balconies and recessed walls, as well as other shading elements, are effective in improving the performance of façade shading. Notably, façade shading causes low surface temperature and provides cool indoor atmosphere during the day when the temperature is extremely high outside. Accordingly, this distinct feature partly explains the current popularity of the neo-minimalist architectural style.

Students’ attitudes to lecturers' English in English-medium higher education in Denmark

DEFF Research Database (Denmark)

Jensen, Christian; Denver, Louise; Mees, Inger M.

2013-01-01

This study examines the evaluative reactions of university students to their non-native lecturers’ English skills in English-medium instruction, i.e. when English is used as a lingua franca in an academic context. In particular, we examine the relationship between perceptions of English language ....... This effect should be addressed when universities use student ratings to evaluate teaching in English-medium content courses.......This study examines the evaluative reactions of university students to their non-native lecturers’ English skills in English-medium instruction, i.e. when English is used as a lingua franca in an academic context. In particular, we examine the relationship between perceptions of English language...... proficiency and perceptions of general lecturing competence (defined here as knowledge of subject and teaching skills). Statistical analyses of 1,700 student responses to 31 non-native English-speaking lecturers at a major business school in Denmark revealed that the students’ perceptions of the lecturers...

Perception of English palatal codas by Korean speakers of English

Science.gov (United States)

Yeon, Sang-Hee

2003-04-01

This study aimed at looking at perception of English palatal codas by Korean speakers of English to determine if perception problems are the source of production problems. In particular, first, this study looked at the possible first language effect on the perception of English palatal codas. Second, a possible perceptual source of vowel epenthesis after English palatal codas was investigated. In addition, individual factors, such as length of residence, TOEFL score, gender and academic status, were compared to determine if those affected the varying degree of the perception accuracy. Eleven adult Korean speakers of English as well as three native speakers of English participated in the study. Three sets of a perception test including identification of minimally different English pseudo- or real words were carried out. The results showed that, first, the Korean speakers perceived the English codas significantly worse than the Americans. Second, the study supported the idea that Koreans perceived an extra /i/ after the final affricates due to final release. Finally, none of the individual factors explained the varying degree of the perceptional accuracy. In particular, TOEFL scores and the perception test scores did not have any statistically significant association.

Current status on advanced aqueous reprocessing process (next) in FaCT project

International Nuclear Information System (INIS)

Washiya, Tadahiro; Myochin, Munetaka; Koyama, Tomozo

2009-01-01

Japan Atomic Energy Agency (JAEA) launched the Fast Reactor Cycle Technology Development (FaCT) project in cooperation with the Japanese electric utilities in 2006. An integration of the advanced aqueous reprocessing concept and the simplified pelletizing fuel fabrication was selected as the most promising fuel cycle system. In order to accomplish the integration, R and D tasks were launched as FaCT Project in 2006 by Japanese joint team. The New Extraction System for TRU Recovery (NEXT) system is an advanced aqueous reprocessing concept which was based on the well established aqueous reprocessing for LWR spent fuel and newly applied processes such as uranium crystallization and extraction chromatography for MAs recovery. Main task of the NEXT process is to develop the TRU recovery process and equipments with high reliability, criticality safety, high durability and remote maintainability. In the FaCT project, all innovative technologies are planned to be developed within the next decade focusing on the future commercialization of FBR cycle systems. The judgment of the adoption of each innovative technology will be made by 2010 based on the results of R and Ds. The development of each technology is to be completed by around 2015. By the same time, it is scheduled to present the conceptual design of commercial and demonstrative fast reactor cycle facilities. The six items (Disassembling and shearing, Fuel dissolution, Uranium Crystallization, Single cycle co-extraction of U, Pu and Np, MA recovery by extraction chromatography and Waste treatment) have been identified as the issues to be developed corresponding to each process step. Current R and D status and prospects of this system until around 2015 is reported. (author)

To Teach Standard English or World Englishes? A Balanced Approach to Instruction

Science.gov (United States)

Farrell, Thomas S. C.; Martin, Sonia

2009-01-01

This article suggests that English language teachers should consider all varieties of English, not just British Standard English or American Standard English. In order to better prepare students for the global world, and to show them that their own English is valued, teachers can implement a balanced approach that incorporates the teaching and…

The scope of inducing natural air supply via the façade

NARCIS (Netherlands)

van den Engel, P.J.W.; Kurvers, S.R.

2017-01-01

An overview is given of recent developments in the use of a system of inducing natural air supply via the façade in the Netherlands. This is followed by a review of the results of measurements from climate chamber experiments of its inducing ventilation performance and detailed insights gained

Pengaruh Kualitas Pelayanan, Harga Dan Lokasi Terhadap Loyalitas Melalui Kepuasan Tamu Pada Santika Premiere Dyandra Hotel & Convention Medan

OpenAIRE

Tambunan, Susi Marta

2016-01-01

Santika Premiere Dyandra Hotel & Convention, Medan, is one of movers in hotel service industry which combines products and services, including the combination of service quality, price, and location in order to attract and provide satisfaction for its guests. It also pays attention to and gives expectation and needs for the guests by giving something correctly which are in line with the guests’ need by providing good performance so that they will be satisfied and will eventually be loyal to t...

English Voices in "Text-to-Speech Tools": Representation of English Users and Their Varieties from a World Englishes Perspective

Science.gov (United States)

Karakas, Ali

2017-01-01

English has experienced grave transformations recently in terms of socio-demographic and geographical characteristics. While such transformations have resulted in diverse types of English uses and various English users, the existing ELT materials still fail to represent the global varieties and dynamic uses and users of English. Moving from a…

Color Image Evaluation for Small Space Based on FA and GEP

Directory of Open Access Journals (Sweden)

Li Deng

2014-01-01

Full Text Available Aiming at the problem that color image is difficult to quantify, this paper proposes an evaluation method of color image for small space based on factor analysis (FA and gene expression programming (GEP and constructs a correlation model between color image factors and comprehensive color image. The basic color samples of small space and color images are evaluated by semantic differential method (SD method, color image factors are selected via dimension reduction in FA, factor score function is established, and by combining the entropy weight method to determine each factor weights then the comprehensive color image score is calculated finally. The best fitting function between color image factors and comprehensive color image is obtained by GEP algorithm, which can predict the users’ color image values. A color image evaluation system for small space is developed based on this model. The color evaluation of a control room on AC frequency conversion rig is taken as an example, verifying the effectiveness of the proposed method. It also can assist the designers in other color designs and provide a fast evaluation tool for testing users’ color image.

Teaching English to Engineers: Between English Language Teaching and Psychology

OpenAIRE

Irina-Ana Drobot

2016-01-01

Teaching English to Engineers is part of English for Specific Purposes, a domain which is under the attention of English students especially under the current conditions of finding jobs and establishing partnerships outside Romania. The paper will analyse the existing textbooks together with the teaching strategies they adopt. Teaching English to Engineering students can intersect with domains such as psychology and cultural studies in order to teach them efficiently. Textbooks for students o...

Researching awareness and attitudes : a study of world Englishes and English teachers in South Korea

OpenAIRE

Ahn, Hyejeong

2017-01-01

This study explores the awareness and attitudes of English teachers in South Korea (ETSK) toward eight selected varieties of English: American English (AmE), British English (BrE), Canadian English (CaE), Singaporean English (SiE), Indian English (InE), Chinese English (ChE), Japanese English (JaE) and Korean English (KoE). Data, consisting of 204 questionnaires and 63 interviews, is collected from both Korean and non-Korean English teachers, from two major regions, Busan Gyeongnam and Seoul ...

Prospective Freshman English Teachers’ Knowledge of the English Sound System

OpenAIRE

TEZEL, Kadir Vefa

2016-01-01

Foreign language teachers use the spoken form of the target language when they teach. One of their professional responsibilities while teaching is to form a good model of pronunciation for their students. In Turkey, English is the primary foreign language taught in all educational institutions. Prospective English teachers in the English Teacher Education departments in Faculties of Education are the products of that system, and they come to their universities having been taught English for y...

Birth order and recalled childhood gender nonconformity in Samoan men and fa'afafine.

Science.gov (United States)

Semenyna, Scott W; VanderLaan, Doug P; Vasey, Paul L

2017-04-01

Having a greater than average number of older biological brothers is a robust correlate of male androphilia (i.e., sexual attraction and arousal to adult males). Previous investigations have sought to understand whether this fraternal birth order (FBO) effect is also systematically related to recalled indicators of childhood gender nonconformity (CGN). However, these investigations have relied on data from low-fertility Western populations in which expressions of femininity in male children are routinely stigmatized and consequently, suppressed. The present study examined the FBO effect (among other sibship characteristics) and recalled indicators of CGN in Samoa, a high-fertility population, whose members are relatively tolerant of male femininity. Indeed, Samoans identify feminine androphilic males as belonging to an alternative gender category, known locally as fa'afafine. The present study compared the sibship characteristics of 231 fa'afafine and 231 opposite-sex attracted men from Samoa, as well as how these characteristics related to recalled CGN. Results replicated the well-established FBO effect for predicting male sexual orientation, with each older brother increasing the odds of being androphilic by 21%. However, no relationship was found between the number of older brothers (or other siblings) a participant had and their recalled CGN. Although fa'afafine reported significantly more CGN than Samoan men, CGN did not mediate the FBO effect, nor did the FBO effect and CGN interact to predict male sexual orientation. These findings are consistent with previous studies suggesting that the FBO effect is associated with male sexual orientation, but not childhood female-typical gender expression among androphilic males. © 2017 Wiley Periodicals, Inc.

Extramural English

DEFF Research Database (Denmark)

Jensen, Signe Hannibal

activities are more supportive of language learning than others, i.e. gaming, watching television, music, etc. Finally, a qualitative gaming study will be carried out to explore what goes on linguistically when very young children game in English together: type of interaction between players...... and with the game and if this interaction can be seen to support their English language learning. Preliminary results indicate that although children use / are exposed to English in a range of different contexts and through a variety of modalities (internet, console/PC games, music etc.), the one activity...... that seems to have the most impact on children’s English learning is gaming....

Recovery from sublethal damage during fractionated irradiation of human FaDu SCC

International Nuclear Information System (INIS)

Petersen, Cordula; Zips, Daniel; Krause, Mechthild; Voelkel, Wolfram; Thames, Howard D.; Baumann, Michael

2005-01-01

Background and purpose: The present study addresses whether recovery of sublethal damage in tumours may change during fractionated irradiation in FaDu human squamous cell carcinoma and whether such an effect might contribute to the pronounced time factor of fractionated irradiation previously found in this tumour. Patients and methods: FaDu tumours were transplanted s.c. into the right hind leg of NMRI nu/nu mice. Single doses or 2, 4, and 8 equal fractions in 3.5 days were applied in previously unirradiated tumours and after priming with 18 fractions of 3 Gy in 18 or 36 days. All irradiations were given under clamp hypoxic conditions. Experimental endpoints were tumour control dose 50% (TCD 50 ) and α/β values without and after priming. Results: Without priming TCD 50 increased with increasing number of fractions from 38.8 Gy (95% CI 35;45) after single dose irradiation to 54.0 Gy (42;57) after 8 fractions. No increase in TCD 50 when given in 1, 2, 4, or 8 fractions in 3.5 days was found after priming with 18 3-Gy fractions in 18 and 36 days. After priming with 18 fractions in 18 days TCD 50 remained constant at 25 Gy and after priming with 18 fractions in 36 days at 42 Gy. The α/β ratio without priming was 68 Gy (42;127). After fractionated irradiation with 18 3-Gy fractions in 18 and 36 days the α/β ratio increased to 317 Gy (38;∞) and to infinite, respectively. Conclusions: Our results indicate that clonogenic cells in FaDu tumours lose entirely their capacity to recover from sublethal radiation damage during fractionated irradiation. Therefore, an increased repair capacity as an explanation for the pronounced time factor of fractionated irradiation in this tumour can be ruled out

English Teaching Profile: Peru.

Science.gov (United States)

British Council, London (England). English Language and Literature Div.

The role and status of English in Peru are examined, with attention directed to: (1) English within the education system; (2) teachers of English; (3) educational administration of English teaching, (4) materials support, development, and planning, (5) English outside the education system; (6) British and American support for the teaching of…

Synthesis of Fulvic Acid-Coated Magnetite (Fe3O4–FA and Its Application for the Reductive Adsorption of [AuCl4]–

Directory of Open Access Journals (Sweden)

Philip Anggo Krisbiantoro

2017-11-01

Full Text Available Fulvic acid-coated magnetite (Fe3O4–FA has been synthesized through coprecipitation method using NH4OH. Synthesis conducted by cheap and environmentally friendly preparation used iron salts and extracted fulvic acid (FA from Peat soil of Rawa Pening, Central Java, Indonesia. Characterization using FT–IR indicated that the coating of FA on Fe3O4 occurred through the formation of chemical bond between iron of Fe3O4 and carboxyl group of FA. The XRD measurement indicated that coated Fe3O4 successfully dispersed in smaller size than uncoated Fe3O4, i.e. from 16.67 to 14.84 nm for Fe3O4 and Fe3O4–FA, respectively. Synthesized Fe3O4–FA has pHPZC 6.37 and stable at pH > 3.0. The extracted FA has total acidity 866.61 cmol kg–1, –COOH content 229.77 cmol kg–1 and –OH content 636.84 cmol kg–1. Fe3O4–FA has total acidity 494.86 cmol kg–1, –COOH content 67.80 cmol kg–1 and –OH content 427.06 cmol kg–1. The adsorption rate constant (k of [AuCl4]– on Fe3O4–A according to the Ho kinetic model was 8006.53 g mol–1 min–1. The adsorption capacity (qmax according to Langmuir isotherm model was 1.24 × 10–4 mol g–1. The presence of reduction towards the adsorbed [AuCl4]– was shown by the appearance of peaks at 2θ: 37.41; 43.66; 64.25, and 76.67° in the XRD diffractogram.

La culture du pois chiche profite à plus grand nombre d'agriculteurs ...

International Development Research Centre (IDRC) Digital Library (Canada)

3 juin 2016 ... Des chercheurs de l'Éthiopie et du Canada s'emploient à trouver des façons de répandre des techniques de production du pois chiche dans les hautes terres de l'Éthiopie, où les autorités ne s'attendaient pas à ce que cette culture soit viable. Au cours des six premiers mois de la présente phase, ...

Data of evolutionary structure change: 1B0FA-2FOCA [Confc[Archive

Lifescience Database Archive (English)

Full Text Available 1B0FA-2FOCA 1B0F 2FOC A A IVGGRRARPHAWPFMVSLQLA----GGHFCGATLIAPNF...>2FOC A 2FOCA SLQYRSGSSWAHTC ...tryChain> 2FOC A 2FOCA PLHCLVNGQY...ine> 2FOC A 2FOCA...in>A 2FOCA HCVDR--ELTFR GG

QUALITY OF NURSING WORK LIFE IMPROVEMENT MODEL TO DECREASE NURSE INTENTION TO QUIT IN PREMIER SURABAYA HOSPITAL

Directory of Open Access Journals (Sweden)

Jany Prihastuty

2017-04-01

Full Text Available Introduction: Quality of Nursing Work Life (QNWL is a thing that needs attention by human resource management approach. The purpose of this research was to provide develop model to increase QNWL in order to lower nurse’s intention to quit the Premier Hospital Surabaya. Methods: Design used in the structure was explanatory research. The independent variables was Internal factors (Individual factors, social and environment conceptual factors, operational factors, administrative factors where as the dependent variable from this study was intention to quit, and moderator variables QNWL random sampling technique. Total sample was 160 nurses, taken according to inclusion criteria. The research was conducted in Premier Hospital Surabaya from October 2012 - July 2013. Data were collected by using structured questionnaire. Data were then analyzed by using multiple linear regression test with level of significance of ≤ 0.05. Result: The results showed, QNWL was influenced by relationships inter-professional part of variabel social and environment conceptual factors, supervision monitoring part of variabel operational factors, career development part of variabel administrative factors. Intention to quit influenced by relationships between nurses, inter-departmental and inter-professional part of variabel social and environment conceptual factors and salaries and benefits part of variabel administrative factors with significant value p = 0.005. Discussion: It can be concluded good inter-professional relation, supervision monitoring, and good career development affected QNWL. Good relationships between nurses, inter-departmental and inter- professional led to lower intention to quit. Low salary and benefits led nurse’s intention to quit getting stronger.

Evaluation of dentoskeletal effects of Farmand functional appliance (Fa II on class II malocclusion

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Yassaei S.

2007-07-01

Full Text Available Background and Aim: Functional appliances refer to a variety of removable or fixed appliances designed to alter the mandibular position both sagitally and vertically, resulting in orthodontic and orthopedic changes. Despite the long history of functional appliances, there is still much controversy related to their effectiveness and mode of action. The aim of this study was to evaluate dental and skeletal effects of Fa II in patients with class II malocclusion due to mandibular deficiency.Materials and Methods: In this before-after clinical trial, 35 patients with class II div I malocclusion were selected. These samples were under treatment with Fa II appliance for 11 months. The range of age of females was 10-13 years and males 11-14 years. Combination analysis was used to determine skeletal and dental effects. Paired t-test was used to compare the differences of mean value pre and post treatment. P<0.05 was considered as the level of significance. Results: There was significant difference between pre and post treatment in respect to posterior and anterior facial height, eruption of upper and lower posterior teeth, eruption of upper anterior teeth, mandibular body length, ANB angle, IMPA and 1 to SN. No significant difference was observed between pre and post treatment regarding facial growth.Conclusion: Treatment with Fa II functional appliance leads to significant alterations in dental and skeletal elements of craniofacial complex and improvement of dental and jaws relationship.

Perceptions of the Coach–Athlete Relationship Predict the Attainment of Mastery Achievement Goals Six Months Later: A Two-Wave Longitudinal Study among F. A. Premier League Academy Soccer Players

Directory of Open Access Journals (Sweden)

Adam R. Nicholls

2017-05-01

Full Text Available All football teams that compete within the F. A. Premier League possess an academy, whose objective is to produce more and better home-grown players that are capable of playing professionally. These young players spend a large amount of time with their coach, but little is known about player’s perception of the coach–athlete relationship within F. A. Premier League Academies. The objectives of this study were to examine whether perceptions of the coach–athlete relationship changed over six months and if the coach–athlete relationship predicted self-reported goal achievement among F. A. Premier League academy players. This study included cross-sectional (n = 104 and longitudinal (n = 52 assessments, in which academy soccer players completed a measure of the coach–athlete relationship and goal achievement across either one or two time periods. The cross-sectional data were subjected to bivariate correlations, whereas the longitudinal data were analyzed using multiple regressions. Perceptions of the coach–athlete relationship remained stable over time. The coach–athlete relationship predicted the achievement of mastery goals six months later. Enhancing the quality of the coach–athlete relationship among elite adolescent athletes appears to be a suitable way of maximizing mastery achievement goals, particularly among developmental athletes who participate in team sports.

First experiments results about the engineering model of Rapsodie; Premiers resultats d'essais interessant le bloc pile de rapsodie

Energy Technology Data Exchange (ETDEWEB)

Chalot, A; Ginier, R; Sauvage, M [Association Euratom-CEA Cadarache (France). Centre d' Etudes Nucleaires

1964-07-01

This report deals with the first series of experiments carried out on the engineering model of Rapsodie and on an associated sodium facility set in a laboratory hall of Cadarache. It conveys more precisely: 1/ - The difficulties encountered during the erection and assembly of the engineering model and a compilation of the results of the first series of experiments and tests carried out on this installation (loading of the subassemblies preheating, thermal chocks...). 2/ - The experiments and tests carried out on the two prototypes control rod drive mechanisms which brought to the choice for the design of the definitive drive mechanism. As a whole, the results proved the validity of the general design principles adopted for Rapsodie. (authors) [French] Ce rapport traite des premiers essais realises sur la maquette du bloc pile de Rapsodie et sur une installation annexe de sodium, implantees dans un hall d'essais de Cadarache. Il fait part: 1/- Des difficultes eprouvees lors du montage de la maquette et rassemble les resultats des premiers essais effectues sur cette installation (chargement des assemblages, prechauffage, chocs thermiques...). 2/- Des essais realises sur deux prototypes de mecanisme de barre de controle qui ont conduit a la conception du mecanisme definitif. L'ensemble des resultats obtenus a permis de confirmer la validite des principes adoptes pour la pile Rapsodie. (auteurs)

Japanese College Students' Attitudes towards Japan English and American English

Science.gov (United States)

Sasayama, Shoko

2013-01-01

This study investigated contemporary Japanese college students' attitudes towards Japan English (JE) and American English (AE) through a verbal guise test (VGT) as well as a questionnaire. Forty-four Japanese college students listened to four Japanese and four North Americans reading a text in English, rated them in terms of solidarity-related…

Remapping Englishness--the Impact of Globalization on College English Instruction in Taiwan

Science.gov (United States)

Lee, Jade Tsui-yu

2008-01-01

The purpose of this paper is to examine the impact of globalization upon the college-level instruction of English/American literature in Taiwan. The examination will be centered upon the subject of Englishness as demonstrated in the courses of English/American Literature taught in Taiwan. By focusing on the term "Englishness," the paper…

A Way of Teaching English Based on Various Fields of English Linguistics

OpenAIRE

小倉, 美津夫

2018-01-01

　The aim of this paper is to analyze the present situation of English teaching in senior high schools in Aichi prefecture, clarify the problems English teachers have had since the 2010 reform of the Course of Study, and suggest that they should take in and use in their classrooms the perspectives of English linguistics. They had learned the introduction of English linguistics at their university before they became teachers, but they haven't noticed how the knowledge of English linguistics is ...

Why Do Primary School English Teachers Decide to Teach English?

Science.gov (United States)

Amengual-Pizarro, Marian; Garcia Laborda, Jesus

2015-01-01

This study is an attempt to explore the nature of L2 teachers' motivation towards English language learning and their decision to become English teachers. A total of 45 third-year prospective Primary school English teachers at the University of the Balearic Islands completed a small-scale survey adapted from Gardner's Attitude/Motivation Test…

World Englishes, English as an International Language and Applied Linguistics

Science.gov (United States)

Kilickaya, Ferit

2009-01-01

The paper discusses World Englishes (WEs) in relation to English as an International Language (EIL) and Applied Linguistics. Taking into account Kachru's interesting but at the same time controversial debate about the status of English in its varieties, which are commonly called WEs and the opposing ideas presented by Quirk, it is aimed to present…

A Comparison of the Reproductive Output Among the Relatives of Samoan Androphilic Fa'afafine and Gynephilic Men.

Science.gov (United States)

Semenyna, Scott W; Petterson, Lanna J; VanderLaan, Doug P; Vasey, Paul L

2017-01-01

The sexually antagonistic gene hypothesis (SAGH) for male androphilia posits that genes associated with androphilia (i.e., sexual attraction to adult males) will result in lowered reproduction when present in males, but increased reproduction when present in females. Findings derived from some Western European samples furnish support for the SAGH; however, results from studies conducted in other regions of the world have been more equivocal. Our previous research in Samoa indicated that the mothers as well as the maternal and paternal grandmothers of androphilic males (known locally as fa'afafine) exhibit elevated reproductive output when compared to the relatives of gynephilic men (i.e., males that are sexually attracted to adult females). The present replication study tested the SAGH in Samoa using a sample that was 122 % larger than the one previously studied by our group (VanderLaan, Forrester, Petterson, & Vasey, 2012). In line with the predictions of the SAGH, we hypothesized that the grandmothers, aunts, and mothers of fa'afafine would show elevated reproductive output compared to those of Samoan gynephilic men. Data were collected from 191 fa'afafine and 191 gynephilic men on the reproductive output of their paternal and maternal biological relatives (i.e., mothers, grandmothers, aunts, uncles). The mothers and maternal grandmothers of fa'afafine showed elevated reproductive output compared to those of gynephilic men. The paternal grandmother effect was not replicated. Although these results are consistent with the SAGH, a lack of difference in the reproductive output of aunts renders support for the SAGH in Samoa equivocal.

Les premiers pas d’Agnon à Jaffa (1908-1912 First Steps of S.Y. Agnon in Jaffa (1908-1912 ראשית דרכו של עגנון ביפו (1908 עד 1912

Directory of Open Access Journals (Sweden)

Masha Itzhaki

2012-11-01

Full Text Available Les premiers pas du célèbre auteur S. Y. Agnon lors de son premier séjour à Jaffa (1908-1912 sont liés aux deux revues hébraïques : Ha-Omer, histoire d’un échec, et Ha-po‘el ha-tsa‘ir, histoire d’une réussite, et aux rédacteurs en chef de ces revues, les écrivains et pères spirituels du jeune Agnon, Sh. Ben Tzion, un écrivain esthétique, bourgeois, et Y. H. Brenner, un penseur tourmenté, un véritable intellectuel socialiste.The first period of the famous writer S. Y. Agnon in Jaffa (1908-1912 has a lot to do with two literary Hebrew periodicals: Ha-Omer, a story of a failure, and Ha-po‘el ha-tsa‘ir, a successful one, as well as  with two major figures in Hebrew literary milieu at that time, the editors, Sh. Ben Tzion and Y. H. Brenner.

Role of the combination of FA and T2* parameters as a new diagnostic method in therapeutic evaluation of parkinson's disease.

Science.gov (United States)

Fang, Yuan; Zheng, Tao; Liu, Lanxiang; Gao, Dawei; Shi, Qinglei; Dong, Yanchao; Du, Dan

2017-11-17

Simple diffusion delivery (SDD) has attained good effects with only tiny amounts of drugs. Fractional anisotropy (FA) and relaxation time T2* that indicate the integrity of fiber tracts and iron concentration within brain tissue were used to evaluate the therapeutic effect of SDD. To evaluate therapeutic effect of SDD in the Parkinson's disease (PD) rat model with FA and T2* parameters. Prospective case-control animal study. Thirty-two male Sprague Dawley rats (eight normal, eight PD, eight SDD, and eight subcutaneous injection rats). Single-shot spin echo echo-planar imaging and fast low-angle shot T 2 WI sequences at 3.0T. Parameters of FA and T2* on the treated side of the substantia nigra were measured to evaluate the therapeutic effect of SDD in a PD rat model. The effects of time on FA and T2* values were analyzed by repeated measurement tests. A one-way analysis of variance was conducted, followed by individual comparisons of the mean FA and T2* values at different timepoints. The FA values on the treated side of the substantia nigra in the SDD treatment group and subcutaneous injection treatment group were significantly higher at week 1 and lower at week 6 than that of the PD control group (SDD vs. PD, week 1, adjusted P = 0.012; subcutaneous vs. PD, week 1, adjusted P T2* parameter in the SDD treatment group and subcutaneous injection treatment group was significantly higher than that in the PD control group at week 6 (SDD vs. PD, adjusted P = 0.032; subcutaneous vs. PD, adjusted P T2* parameters can potentially serve as a new effective evaluation method of the therapeutic effect of SDD. 1 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2017. © 2017 International Society for Magnetic Resonance in Medicine.

English language status and English communication in culturally diverse academic departments

DEFF Research Database (Denmark)

Selmer, Jan; Lauring, Jakob

2011-01-01

universities, results showed that English fluency had a positive association with inter-individual communication and management communication, both in English, while linguistic distance only had a positive relationship with inter-individual communication in English. Implications of these findings are discussed...

English in Fiji.

Science.gov (United States)

Siegel, Jeff

1989-01-01

Traces the history of English in Fiji, especially in relation to education. The role of English in interethnic communication and as a language of wider communication with the outside world is discussed, and features of Fiji English, a local language variety, are described. (Author/CB)

F-15A Versus F/A-22 Initial Operational Capability. A Case for Transformation

National Research Council Canada - National Science Library

Mott V, William H

2005-01-01

The F/A-22 Raptor is a new weapons system replacing- the F-15C Eagle. Its operational debut in 2005 comes at a time of constrained budgets, a changing global threat environment, and the ongoing global war on terrorism (GWOT...

On Differences between General English Teaching and Business English Teaching

Science.gov (United States)

Zhu, Wenzhong; Liao, Fang

2008-01-01

With the accelerating rate of globalization, business exchanges are carried out cross the border, as a result there is a growing demand for talents professional both in English and Business. We can see that at present Business English courses are offered by many language schools in the aim of meeting the need for Business English talent. Many…

Development of a simplified method for intelligent glazed façade design under different control strategies and verified by building simulation tool BSim

DEFF Research Database (Denmark)

Liu, Mingzhe; Wittchen, Kim Bjarne; Heiselberg, Per

2014-01-01

The research aims to develop a simplified calculation method for intelligent glazed facade under different control conditions (night shutter, solar shading and natural ventilation) to simulate the energy performance and indoor environment of an office room installed with the intelligent facade......, it is possible to calculate the whole year performance of a room or building with intelligent glazed façade, which makes it a less time consuming tool to investigate the performance of the intelligent façade under different control strategies in the design stage with acceptable accuracy. Results showed good....... The method took the angle dependence of the solar characteristic into account, including the simplified hourly building model developed according to EN 13790 to evaluate the influence of the controlled façade on both the indoor environment (indoor air temperature, solar transmittance through the façade...

The use of matrigel has no influence on tumor development or PET imaging in FaDu human head and neck cancer xenografts

DEFF Research Database (Denmark)

Fliedner, Frederikke P.; Hansen, Anders Elias; Jorgensen, Jesper T.

2016-01-01

is currently available. This study evaluates the potential effect of matrigel use in a human head and neck cancer xenograft model (FaDu; hypopharyngeal carcinoma) in NMRI nude mice. The FaDu cell line was chosen based on its frequent use in studies of cancer imaging and tumor microenvironment. Methods: NMRI...... nude mice (n = 34) were divided into two groups and subcutaneously injected with FaDu cells in medium either including (+MG) or excluding matrigel (-MG). In sub study I seven mice from each group (+MG, n = 7; -MG, n = 7) were 18F-fluorodeoxyglucose (18F-FDG) PET/CT scanned on Day 5, 8, 12, 15, and 19...... for the FaDu xenograft model evaluated. Tumors in the -MG group displayed increased angiogenesis compared to the +MG tumors. No difference in 18F-FDG PET uptake for tumors of different groups was found. Based on these observations the influence of matrigel on tumor imaging and tumor microenvironment seems...

Non-Native & Native English Teachers

Directory of Open Access Journals (Sweden)

İrfan Tosuncuoglu

2017-12-01

Full Text Available In many countries the primary (mother tongue language is not English but there is a great demand for English language teachers all over the world. The demand in this field is try to be filled largely by non-native English speaking teachers who have learned English in the country or abroad, or from another non native English peaking teachers. In some countries, particularly those where English speaking is a a sign of status, the students prefer to learn English from a native English speaker. The perception is that a non-native English speaking teacher is a less authentic teacher than a native English speaker and their instruction is not satifactory in some ways. This paper will try to examine the literature to explore whether there is a difference in instructional effectiveness between NNESTs and native English teachers.

ENGLISH / PIDGIN-ENGLISH (WES-KOS), PRELIMINARY GLOSSARY.

Science.gov (United States)

SCHNEIDER, GILBERT D.

THIS PRELIMINARY GLOSSARY OF ENGLISH / PIDGIN-ENGLISH (WES-KOS) HAS BEEN USED IN PEACE CORPS TRAINING PROGRAMS. WES-KOS (IN USE SINCE THE 18TH CENTURY) IS USED THROUGHOUT WEST AFRICA, HOWEVER THE GLOSSES IN THIS TEXT ARE THE COMMON CULTURAL-LINGUISTIC EQUIVALENTS USED IN WEST CAMEROON AND EASTERN NIGERIA. A BRIEF STATEMENT IS GIVEN IN THE…

Targeting property and toxicity of a novel ultrasound contrast agent microbubble carrying the targeting and drug-loaded complex FA-CNTs-PTX on MCF7 cells.

Science.gov (United States)

Zhang, Jie; Zhang, Yu; Liu, Junxi; Li, Guozhong; Wen, Zhaohui; Zhao, Yue; Zhang, Xiangyu; Liu, Fenghua

2017-10-01

The application of ultrasound contrast agents not only is confined to the enhancement of ultrasound imaging but also has started to be used as a drug system for diagnosis and treatment. In this paper, Span60 and PEG1500 were used as membrane materials, and a new targeting and drug-loading multifunctional ultrasound contrast agent microbubble enveloping the FA-CNTs-PTX complex was successfully prepared by acoustic cavitation. With the breast cancer cell line MCF7 as the research target, the effects of the microbubble with FA-CNTs-PTX on the proliferation and toxicity of MCF7 cells were studied using a CCK-8 and AO/EB double-staining method. The influences of the microbubbles with FA-CNTs-PTX on the cellular morphology and apoptosis period of the MCF7 cells were detected using an inverted fluorescence microscope. The apoptosis of MCF7 cells induced by the microbubbles with FA-CNTs-PTX was investigated with flow cytometry and an annexin and PI double staining fluorescence quantitative analysis. The results indicated that the ultrasound contrast agent microbubble with FA-CNTs-PTX remarkably inhibited the proliferation of MCF7 cells, which was mainly controlled by the drug loading rate and the nanometer size of the microbubbles. Moreover, the proliferative inhibition rate of the microbubbles with FA-CNTs-PTX was related to the cell apoptosis period of MCF7 cells. Its inhibition degree on the proliferation of MCF7 cells was higher than that of the hepatoma HepG2 cells. The apoptosis rate of MCF7 cells induced by the microbubbles with FA-CNTs-PTX was higher than that of normal human umbilical vein endothelial cells (HUVECs), and the microbubbles with FA-CNTs-PTX could target the MCF7 cells. Copyright © 2017 Elsevier B.V. All rights reserved.

English Phonetics

DEFF Research Database (Denmark)

potential applications helping to provide solutions to problems encountered in the real world. An area of prime importance was the teaching of pronunciation to language learners, and in particular the acquisition of English pronunciation by non-natives. Apart from works devoted to second...... Melville Bell, Isaac Pitman, Alexander J. Ellis, and Henry Sweet—the emphasis was on what is now known as articulatory phonetics. (See further Phonetics of English in the Nineteenth Century (Routledge, 2006), compiled by the editors of the current collection.) These pioneers regarded their task......-language acquisition, and in particular to the teaching of English as an acquired language, this emphasis also led to the production of important English pronunciation dictionaries, including the Afzelius dictionary reproduced as Volume I of this collection. Other areas covered in the following volumes include key...

Construct validity of the Heart Failure Screening Tool (Heart-FaST) to identify heart failure patients at risk of poor self-care: Rasch analysis.

Science.gov (United States)

Reynolds, Nicholas A; Ski, Chantal F; McEvedy, Samantha M; Thompson, David R; Cameron, Jan

2018-02-14

The aim of this study was to psychometrically evaluate the Heart Failure Screening Tool (Heart-FaST) via: (1) examination of internal construct validity; (2) testing of scale function in accordance with design; and (3) recommendation for change/s, if items are not well adjusted, to improve psychometric credential. Self-care is vital to the management of heart failure. The Heart-FaST may provide a prospective assessment of risk, regarding the likelihood that patients with heart failure will engage in self-care. Psychometric validation of the Heart-FaST using Rasch analysis. The Heart-FaST was administered to 135 patients (median age = 68, IQR = 59-78 years; 105 males) enrolled in a multidisciplinary heart failure management program. The Heart-FaST is a nurse-administered tool for screening patients with HF at risk of poor self-care. A Rasch analysis of responses was conducted which tested data against Rasch model expectations, including whether items serve as unbiased, non-redundant indicators of risk and measure a single construct and that rating scales operate as intended. The results showed that data met Rasch model expectations after rescoring or deleting items due to poor discrimination, disordered thresholds, differential item functioning, or response dependence. There was no evidence of multidimensionality which supports the use of total scores from Heart-FaST as indicators of risk. Aggregate scores from this modified screening tool rank heart failure patients according to their "risk of poor self-care" demonstrating that the Heart-FaST items constitute a meaningful scale to identify heart failure patients at risk of poor engagement in heart failure self-care. © 2018 John Wiley & Sons Ltd.

Japanese Media in English.

Science.gov (United States)

Tanaka, Sachiko Oda

1995-01-01

Describes the use of English in the media in Japan, focusing on the role and history of English-language newspapers, radio, and television programs, as well as the proliferation of English-language films shown in Japanese cinemas. Discusses the implications of English in the Japanese media. (20 references) (MDM)

NEEDS ANALYSIS OF ENGLISH LITERATURE STUDENTS IN ENGLISH ORAL COMMUNICATION

Directory of Open Access Journals (Sweden)

Angga Maulana

2017-12-01

Full Text Available The purpose of this study is to identify factual information about the needs of students of English Literature in the activities and supporting factors of oral communication by using English, whether linguistic and non-linguistic, and analyzing the difficulties of the situation of oral communication of English Literature students using English. This research uses descriptive method. Data collection is done through two stages: the questionnaire and the interview, followed by the review of someliteratures. The results of this study indicate that in general the students of English Literature feel that participating in a formal discussion is more important than the informal. While in terms of ability in the oral communication activity, generally students mastered informal communication activities. In terms of linguistic factors, the choice of vocabularies, and good and correct sentences are considered very important, although they only feel quite capable in it. It is also found that talking with self-confidence, having proper English pronunciation and mastering the topic of conversation become the important non-linguistic factors. The same thing does not happen on loudness and facial mimic. In general, students feel it is not important enough to master. Regarding situations that facilitate students in oral communication in English, they generally feel that well preparation, self-confidence, and mastery over vocabulary and what is being discussed becomes an easier factor. Different things revealed by most students about the difficult vocabulary and the lack of preparation in oral communication. It is difficult. As for things that require improvement, students generally feel that the confidence and the amount of vocabulary that is mastered should be improved in order to improve the quality of oral communication in English.

A new fast data logger and viewer at Diamond: the FA archiver

International Nuclear Information System (INIS)

Abbott, M.G.; Rehm, G.; Uzun, I.S.

2012-01-01

At Diamond Light Source, position data from 174 Electron Beam Position Monitors (BPMs) and a number of X-Ray BPMs is distributed over the Fast Acquisition communications network at an update rate of 10 kHz; the total aggregate data rate is around 15 MB/s. The data logger described here (the FA Archiver) captures this entire data stream to disk in real time, re-broadcasts selected subsets of the live stream on demand to interested clients, and allows rapid access to any part of the saved data. The archive is saved into a rolling buffer allowing retrieval of detailed beam position data from any time in the last four days. A simple socket-based interface to the FA Archiver allows easy access to both stored and live data from a variety of clients. Clients include a graphical viewer for visualizing the motion or spectrum of a single BPM in real time, a command line tool for retrieving any part of the stored data by time of day, and Matlab scripts for exploring the dataset, helped by the storage of decimated minimum, maximum, mean, and standard deviation data. (authors)

Objective and subjective evaluation of façade sound insulation

DEFF Research Database (Denmark)

Ordoñez, Rodrigo Pizarro; Visentin, Chiara; Markovic, Milos

2013-01-01

by filtering recordings of traffic noise with the frequency response of sound insulation measurements. The measurements were performed in typical Italian buildings in accordance with the ISO 140-5 standard. The objectives of the present paper are to compare the subjective evaluations obtained with the two......Façade insulation of several different construction types were subjectively evaluated using two psychoacoustic methods: paired comparisons using a two alternative forced choice (2-AFC) paradigm and direct scaling using a visual analogue scale (VAS). The stimuli used in the evaluations were obtained...

THE ROLE OF OUT-OF-SCHOOL ENGLISH LITERACY ACTIVITIES IN PROMOTING STUDENTS’ ENGLISH LITERACY

Directory of Open Access Journals (Sweden)

LILIES SETIASIH

2014-01-01

Full Text Available This paper reports on a case study of the role of out-of-school English literacy activities in promoting students’ English literacy at an elementary school in Bandung. The study is an attempt to respond to controversy among decision makers about the idea of offering English at elementary schools and the reality that at the school where the research was conducted, English is fully used as a means of instruction for English, Mathematics, and Science. Considering that literacy is shaped in socio-cultural contexts, the researcher assumed that the students acquired and developed their English literacy not only at school but also outside of school. Their out-of-school English literacy activities might contribute to their English literacy development. The research aims were to investigate the students’ English literacy level and to identify their out-of-school literacy activities. The theoretical framework covered the cognitive and socio-cultural theories of literacy. The research results were: 1 the majority of the fourth grade students were in early advanced and advanced levels for the aspects of reading and writing proficiency; and 2 their out-of-school English literacy activities played an important role in building their English literacy.

FA1 Induces Pro-Inflammatory and Anti-Adipogenic Pathways/Markers in Human Myotubes Established from Lean, Obese, and Type 2 Diabetic Subjects but Not Insulin Resistance

DEFF Research Database (Denmark)

Abdallah, Basem M; Beck-Nielsen, Henning; Gaster, Michael

2013-01-01

Aims: Delta like 1/fetal antigen 1 (Dlk1/FA1) is a protein secreted by hormone producing cells in adult human and mice that is known to inhibit adipogenesis. Recent studies demonstrated the role of Dlk1/FA1 in inducing insulin resistance in mice. To investigate the involvement of circulating Dlk1....../FA1 in insulin resistance and type 2 diabetes in human subjects, we studied the effects of chronic FA1 on the intermediary metabolism in myotubes established from lean, obese, and type 2 diabetic (T2D) subjects. Methods: Myotube cultures were established from lean and obese control subjects......, and obese T2D subjects and treated with soluble FA1 for 4 days supplemented with/without palmitate (PA). Lipid- and glucose metabolism were studied with labeled precursors while quantitative expression of genes was analyzed using real-time PCR. Results: Diabetic myotubes express significantly reduced...

Chinese College Students' Views on Native English and Non-Native English in EFL Classrooms

Science.gov (United States)

Qian, Yang; Jingxia, Liu

2016-01-01

With the development of globalization, English is clearly spoken by many more non-native than native speakers, which raises the discussion of English varieties and the debate regarding the conformity to Standard English. Although a large number of studies have shown scholars' attitudes towards native English and non-native English, little research…

A Language without Borders: English Slang and Bulgarian Learners of English

Science.gov (United States)

Charkova, Krassimira D.

2007-01-01

This study investigated the acquisition of English slang in a foreign language context. The participants were 101 Bulgarian learners of English, 58 high school students, and 43 university students. The instrument included knowledge tests of English slang terms and questions about attitudes, sources, reasons, and methods employed in learning…

Study on Correlation of English Pronunciation Self-Concept to English Learning

Science.gov (United States)

Tang, Xin; Zhang, Shengqi; Li, Yucong; Zhao, Miqiang

2013-01-01

English pronunciation self-concept is formed in the process of pronunciation learning, which refers to the learners' self-conception and assessment of one's English pronunciation proficiency and pronunciation (Gimson, A. C. 1980). This paper reports an investigation on 237 non-English major college students into the relationship between English…

AFSC/ABL: Origins of sockeye and chum salmon seized from the F/V Ying Fa

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Samples of chum (Oncorhynchus keta) and sockeye (O. nerka) salmon seized from the stateless fishing vessel Ying Fa were analyzed to determine their region of origin...

A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development.

Directory of Open Access Journals (Sweden)

Philip J Byrd

2016-03-01

Full Text Available Patients with biallelic truncating mutations in PALB2 have a severe form of Fanconi anaemia (FA-N, with a predisposition for developing embryonal-type tumours in infancy. Here we describe two unusual patients from a single family, carrying biallelic PALB2 mutations, one truncating, c.1676_1677delAAinsG;(p.Gln559ArgfsTer2, and the second, c.2586+1G>A; p.Thr839_Lys862del resulting in an in frame skip of exon 6 (24 amino acids. Strikingly, the affected individuals did not exhibit the severe developmental defects typical of FA-N patients and initially presented with B cell non-Hodgkin lymphoma. The expressed p.Thr839_Lys862del mutant PALB2 protein retained the ability to interact with BRCA2, previously unreported in FA-N patients. There was also a large increased chromosomal radiosensitivity following irradiation in G2 and increased sensitivity to mitomycin C. Although patient cells were unable to form Rad51 foci following exposure to either DNA damaging agent, U2OS cells, in which the mutant PALB2 with in frame skip of exon 6 was induced, did show recruitment of Rad51 to foci following damage. We conclude that a very mild form of FA-N exists arising from a hypomorphic PALB2 allele.

Teacher of primary English

CERN Multimedia

2003-01-01

Part-time teacher of primary English needed for September 2003 to teach English National Curriculum (KS2) and NLS to mother tongue or good second language English-speakers aged 7-10. 4 hours contact time per week, team planning, marking and meetings. Candidates should be English mother tongue qualified teachers, confident, flexible classroom practitioners and team players. For further details and how to apply see http://enpferney.org/staff_vacancies.htm English National Programme, Lycée International, Ferney-Voltaire (http://enpferney.org/)

Acceptabilité du test VIH proposé aux nourrissons dans les services ...

African Journals Online (AJOL)

Maxime Oga

4 août 2014 ... pesée ou consultation de pédiatrie générale dans l'un des centres de ... du primaire (19 me`res) au secondaire (premier cycle, 9 me`res),. (second cycle, 7 .... et/ou d'attendre son avis pour la réalisation du soin qu'exige le diagnostic. ..... et les médecins les suivent pour leur bonne santé. » FA 116,. 31 ans ...

English

DEFF Research Database (Denmark)

Phillipson, Robert

2011-01-01

The article exemplifies and presents the characteristics of linguistic imperialism, linguistic capital accumulation following the same pattern as capitalist economic dominance. The text summarizes the way English was established in the colonial period. Many of the mechanisms of linguistic hierarchy...... have been maintained and intensified since then, as African and Indian scholarship demonstrates. Language plays a key role in education, the World Bank taking over where colonial regimes left off. Anglo-American efforts to maintain global English dominance have intensified since 1945 and are central...... to the present-day world ‘order’, as the postcolonial is subsumed under global empire, assisted by English linguistic neoimperialism. Some scholars who deny the existence of linguistic imperialism are reported on, and the complexity of language policy in European integration is demonstrated. The article...

Online English-English Learner Dictionaries Boost Word Learning

Science.gov (United States)

Nurmukhamedov, Ulugbek

2012-01-01

Learners of English might be familiar with several online monolingual dictionaries that are not necessarily the best choices for the English as Second/Foreign Language (ESL/EFL) context. Although these monolingual online dictionaries contain definitions, pronunciation guides, and other elements normally found in general-use dictionaries, they are…

English made easy

CERN Document Server

Crichton, Jonathan

2013-01-01

This is a fun and user–friendly way to learn English English Made Easy is a breakthrough in English language learning—imaginatively exploiting how pictures and text can work together to create understanding and help learners learn more productively. It gives learners easy access to the vocabulary, grammar and functions of English as it is actually used in a comprehensive range of social situations. Self–guided students and classroom learners alike will be delighted by the way they are helped to progress easily from one unit to the next, using a combination of pictures and text to discover for themselves how English works. The pictorial method used in this book is based on a thorough understanding of language structure and how language is successfully learned.English Made Easy, Volume 1 consists of a total of 20 units arranged in groups of five. The first four units presents language and provide learners the opportunities to practice as they learn. The first page of each unit has a list of all the word...

English made easy

CERN Document Server

Crichton, Jonathan

2013-01-01

This is a fun and user–friendly way to learn EnglishEnglish Made Easy is a breakthrough in English language learning—imaginatively exploiting how pictures and text can work together to create understanding and help learners learn more productively. It gives learners easy access to the vocabulary, grammar and functions of English as it is actually used in a comprehensive range of social situations. Self–guided students and classroom learners alike will be delighted by the way they are helped to progress easily from one unit to the next, using a combination of pictures and text to discover for themselves how English works. The pictorial method used in this book is based on a thorough understanding of language structure and how language is successfully learned.English Made Easy, Volume 2 consists of a total of 20 units arranged in groups of five. The first four units presents language and provide learners the opportunities to practice as they learn. The first page of each unit has a list of all the words...

Evaluation of sports nutrition knowledge of New Zealand premier club rugby coaches.

Science.gov (United States)

Zinn, Caryn; Schofield, Grant; Wall, Clare

2006-04-01

Little is known about if and how team coaches disseminate nutrition information to athletes. In a census survey, New Zealand premier rugby coaches (n = 168) completed a psychometrically validated questionnaire, received by either Internet or standard mail (response rate, 46%), identifying their nutrition advice dissemination practices to players, their level of nutrition knowledge, and the factors determining this level of knowledge. The majority of coaches provided advice to their players (83.8%). Coaches responded correctly to 55.6% of all knowledge questions. An independent t-test showed coaches who imparted nutrition advice obtained a significantly greater score, 56.8%, than those not imparting advice, 48.4% (P = 0.008). One-way ANOVA showed significant relationships between total knowledge score of all coaches and qualifications [F(1,166) = 5.28, P = 0.001], own knowledge rating [F(3,164) = 6.88, P = 0.001] and nutrition training [F(1,166) = 9.83, P = 0.002]. We conclude that these rugby coaches were inadequately prepared to impart nutrition advice to athletes and could benefit from further nutrition training.

English for au pairs the au pair's guide to learning English

CERN Document Server

Curtis, Lucy

2014-01-01

English for Au Pairs has interlinked stories about a group of au pairs new to England. Marta, an 18-year-old from Poland arrives in the UK to work as an au pair. Throughout her year-long stay she has many different experiences - some bad, some good - but with the support of her host family she finds new friends and improves her English. English for Au Pairs offers insight into the joys and difficulties of being an au pair while at the same time reinforcing English language learning through grammar explanations and exercises.

CALL English

DEFF Research Database (Denmark)

Barlach, Else

This multimedia program of English grammar caters specifically for Danish students at Bachelor level. The handbook introduces students to well-established grammatical terminology within the traditional areas of English grammar, and the CD-ROM, which contains about 120 exercises, offers students...

Linear systems surviving the first breakdown; Systemes unbaires survivant a la premiere panne

Energy Technology Data Exchange (ETDEWEB)

Uberschlag, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1967-07-01

Various types of linear systems are described which are not affected by the first breakdown. They make it possible to operate continuously and are thus very reliable. This is because the first breakdown which occurs affects only very slightly the operation. These components can be replaced during working. The operation, the errors, and the detection are briefly considered in the case of three different designs of linear servo systems. An attempt at comparison is made, it could be developed in a particular case. (author) [French] On decrit divers types de systemes lineaires survivant a la premiere panne. Ils permettent un fonctionnement permanent et sont donc d'une tres grande fiabilite. En effet, une panne, qui peut etre signalee, perturbe peu le fonctionnement. Ces composants peuvent etre remplaces en marche. Les considerations de fonctionnement, d'erreur, de detection des pannes sont succinctement presentees, sur trois schemas de systemes lineaires asservis. Une tentative de comparaison est faite, qui pourrait etre developpee dans des cas precis. (auteur)

Examining behavioral processes through which lifestyle interventions promote weight loss: results from PREMIER.

Science.gov (United States)

Fitzpatrick, Stephanie L; Bandeen-Roche, Karen; Stevens, Victor J; Coughlin, Janelle W; Rubin, Richard R; Brantley, Phillip J; Funk, Kristine L; Svetkey, Laura P; Jerome, Gerald J; Dalcin, Arlene; Charleston, Jeanne; Appel, Lawrence J

2014-04-01

To examine the behavioral processes through which lifestyle interventions impacted weight loss. The analyses were limited to overweight and obese Black and White adults randomized to a PREMIER lifestyle intervention (N = 501). Structural equation modeling was conducted to test the direct and indirect relationships of session attendance, days of self-monitoring diet and exercise, change in diet composition and exercise, and 6-month weight change. Greater session attendance was associated with increased self-monitoring, which was in turn significantly related to reduction in percent energy from total fat consumed. Change in percent energy from fat and self-monitoring was associated with 6-month percent change in weight. Both a decrease in fat intake and increase in self-monitoring are potential mediators of the relationship between attendance and weight change. The findings provide a reasonable model that suggests regular session attendance and use of behavioral strategies like self-monitoring are associated with improved behavioral outcomes that are associated with weight loss. Copyright © 2013 The Obesity Society.

Towards Improving our Understanding on the Retrievals of Key Parameters Characterising Land Surface Interactions from Space: Introduction & First Results from the PREMIER-EO Project

Science.gov (United States)

Ireland, Gareth; North, Matthew R.; Petropoulos, George P.; Srivastava, Prashant K.; Hodges, Crona

2015-04-01

Acquiring accurate information on the spatio-temporal variability of soil moisture content (SM) and evapotranspiration (ET) is of key importance to extend our understanding of the Earth system's physical processes, and is also required in a wide range of multi-disciplinary research studies and applications. The utility and applicability of Earth Observation (EO) technology provides an economically feasible solution to derive continuous spatio-temporal estimates of key parameters characterising land surface interactions, including ET as well as SM. Such information is of key value to practitioners, decision makers and scientists alike. The PREMIER-EO project recently funded by High Performance Computing Wales (HPCW) is a research initiative directed towards the development of a better understanding of EO technology's present ability to derive operational estimations of surface fluxes and SM. Moreover, the project aims at addressing knowledge gaps related to the operational estimation of such parameters, and thus contribute towards current ongoing global efforts towards enhancing the accuracy of those products. In this presentation we introduce the PREMIER-EO project, providing a detailed overview of the research aims and objectives for the 1 year duration of the project's implementation. Subsequently, we make available the initial results of the work carried out herein, in particular, related to an all-inclusive and robust evaluation of the accuracy of existing operational products of ET and SM from different ecosystems globally. The research outcomes of this project, once completed, will provide an important contribution towards addressing the knowledge gaps related to the operational estimation of ET and SM. This project results will also support efforts ongoing globally towards the operational development of related products using technologically advanced EO instruments which were launched recently or planned be launched in the next 1-2 years. Key Words: PREMIER

Non-Native English Speakers and Nonstandard English: An In-Depth Investigation

Science.gov (United States)

Polat, Brittany

2012-01-01

Given the rising prominence of nonstandard varieties of English around the world (Jenkins 2007), learners of English as a second language are increasingly called on to communicate with speakers of both native and non-native nonstandard English varieties. In many classrooms around the world, however, learners continue to be exposed only to…

Non-Native English Varieties: Thainess in English Narratives

Science.gov (United States)

Singhasak, Piyahathai; Methitham, Phongsakorn

2016-01-01

This study aims at examining Thainess as a writing strategy used in non-literary texts written by non-professional bilingual writers. These writers are advanced language learners who are pursuing their Master's degree in English. Seven English narratives of their language learning experiences were analyzed based on Kachruvian's framework of…

Leaching of biocides used in façade coatings under laboratory test conditions.

Science.gov (United States)

Schoknecht, Ute; Gruycheva, Jana; Mathies, Helena; Bergmann, Hannelore; Burkhardt, Michael

2009-12-15

The European Biocidal Products Directive 98/8/EC requires a risk assessment concerning possible effects of active ingredients on the environment. Biocides can be leached from treated materials exposed to outdoor use. These emissions have to be estimated and evaluated during the authorization procedure. Different immersion and irrigation tests were performed to investigate leaching of biocides from façade coatings. Several marketed formulations of textured coatings and paints spiked with a mixture of commonly used active ingredients (OIT, DCOIT, IPBC, carbendazim, isoproturon, diuron, terbutryn, and Irgarol 1051) were investigated. The emission process can be described by time-dependent functions that depend on the test conditions. The results of all test procedures confirm that leachability is related to water solubility and n-octanol-water partition coefficient of the active ingredients and that leaching of biocides from façade coatings is mainly a diffusion controlled process. Other factors like the composition of the product, availability and transport of water, concentration of active ingredients in the coatings, as well as UV-exposure of the coatings influence biocide emissions.

TEACHER OF ENGLISH NEEDED

CERN Multimedia

2002-01-01

Part-time teacher of primary English needed for September 2002 to teach English National Curriculum (KS2) and NLS to mother tongue or good second language English-speakers aged 7-10. 4 hours contact time per week, team planning, marking and meetings. Candidates should be English mother tongue qualified teachers, confident, flexible classroom practitioners and team players. For further details and how to apply: engnat@hotmail.com or 04 50 40 82 66. Apply as soon as possible, and in any case before 8 July. English National Programme, Lycée International, Ferney-Voltaire.

A critical evaluation of fasted state simulating gastric fluid (FaSSGF) that contains sodium lauryl sulfate and proposal of a modified recipe.

Science.gov (United States)

Aburub, Aktham; Risley, Donald S; Mishra, Dinesh

2008-01-22

The aim of this work is to evaluate one of the most commonly used fasted state simulating gastric fluids (FaSSGFs), which contains sodium lauryl sulfate (SLS) (FaSSGF(SLS)), and propose a more appropriate surfactant concentration. Surface tension studies clearly show that the critical micelle concentration (CMC) of SLS in the relevant media (a media whose pH and sodium chloride concentration are representative of physiological conditions) is significantly lower (p<0.05) than 8.67 mM, which is the SLS concentration in FaSSGF(SLS). The CMC of SLS in the relevant media was determined to be 1.75 mM. Based on this a modified recipe is proposed in which the concentration of SLS is sufficient to achieve a surface tension similar to that in vivo without causing artificial micellar solubilization. Solubility, intrinsic dissolution, and GastroPlus modeling studies are presented to support and give rationale for the modified recipe. In addition, a comparison between the modified recipe and other FaSSGFs reported in the literature is made.

Orientations towards English among English-Medium Instruction Students

Science.gov (United States)

Karakas, Ali

2015-01-01

Based on the empirical data of my PhD research, this paper analyses the perceptions of 351 undergraduate students enrolled at English-medium universities towards English in terms of the language ideology framework. The students were purposively sampled from three programs at three Turkish universities. The data were drawn from student opinion…

English Verb Accuracy of Bilingual Cantonese-English Preschoolers

Science.gov (United States)

Rezzonico, Stefano; Goldberg, Ahuva; Milburn, Trelani; Belletti, Adriana; Girolametto, Luigi

2017-01-01

Purpose: Knowledge of verb development in typically developing bilingual preschoolers may inform clinicians about verb accuracy rates during the 1st 2 years of English instruction. This study aimed to investigate tensed verb accuracy in 2 assessment contexts in 4- and 5-year-old Cantonese-English bilingual preschoolers. Method: The sample included…

Perception of "English" and Motivation in Learning English

Science.gov (United States)

Sahin, Mehmet; Seçer, Sule Y. E.; Erisen, Yavuz

2016-01-01

This study aims to present high school students' perception of "English" through the impressions and images and the effect of these perceptions on their motivation in learning English. This qualitative study is based on the data about students' metaphors and the focus group interview to determine their effect on the students' motivation.…

Diffusion tensor imaging of the median nerve at 3.0 T using different MR scanners: Agreement of FA and ADC measurements

International Nuclear Information System (INIS)

Guggenberger, Roman; Nanz, Daniel; Bussmann, Lorenz; Chhabra, Avneesh; Fischer, Michael A.; Hodler, Jürg; Pfirrmann, Christian W.A.; Andreisek, Gustav

2013-01-01

Objective: To assess the agreement of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of the median nerve on 3.0 T MR scanners from different vendors. Materials and methods: IRB approved study including 16 healthy volunteers (9 women; mean age 30.6 ± 5.3 years). Diffusion tensor imaging (DTI) of the dominant wrist was performed on three 3.0 T MR scanners (GE, Siemens, Philips) using similar imaging protocols and vendor-proprietary hard- and software. Intra-, inter-reader and inter-vendor agreements were assessed. Results: ICCs for intra-/inter-reader agreements ranged from 0.843–0.970/0.846–0.956 for FA, and 0.840–0.940/0.726–0.929 for ADC, respectively. ANOVA analysis identified significant differences for FA/ADC measurements among vendors (p −3 mm 2 /s (SD ± 0.134 × 10 −3 ) for ADC. A significant negative measurement bias was found for FA values from the GE scanner (−0.05 and −0.07) and for ADC values from the Siemens scanner (−0.053 and −0.063 × 10 −3 mm 2 /s) as compared to the remainder vendors Conclusion: FA and ADC values of the median nerve obtained on different 3.0 T MR scanners differ significantly, but are in comparison to the standard deviation of absolute values small enough to not have an impact on larger group studies or when substantial diffusion changes can be expected. However, caution is warranted in an individual patient when interpreting diffusion values from different scanner acquisitions

Thanking Responders in Cameroon English

Science.gov (United States)

Ouafeu, Yves Talla Sando

2009-01-01

An analysis of authentic or genuine interactions among Cameroon English speakers reveals that conversational routines in this variety of English differ a good deal from those obtained in other varieties of English, non-native varieties of English inclusive, and more specifically in native varieties of English. This paper looks at "thanking…

Understanding Disorder Within Variation: Production of English Grammatical Forms by English Language Learners.

Science.gov (United States)

Bedore, Lisa M; Peña, Elizabeth D; Anaya, Jissel B; Nieto, Ricardo; Lugo-Neris, Mirza J; Baron, Alisa

2018-04-05

This study examines English performance on a set of 11 grammatical forms in Spanish-English bilingual, school-age children in order to understand how item difficulty of grammatical constructions helps correctly classify language impairment (LI) from expected variability in second language acquisition when taking into account linguistic experience and exposure. Three hundred seventy-eight children's scores on the Bilingual English-Spanish Assessment-Middle Extension (Peña, Bedore, Gutiérrez-Clellen, Iglesias, & Goldstein, 2008) morphosyntax cloze task were analyzed by bilingual experience groups (high Spanish experience, balanced English-Spanish experience, high English experience, ability (typically developing [TD] vs. LI), and grammatical form. Classification accuracy was calculated for the forms that best differentiated TD and LI groups. Children with LI scored lower than TD children across all bilingual experience groups. There were differences by grammatical form across bilingual experience and ability groups. Children from high English experience and balanced English-Spanish experience groups could be accurately classified on the basis of all the English grammatical forms tested except for prepositions. For bilinguals with high Spanish experience, it was possible to rule out LI on the basis of grammatical production but not rule in LI. It is possible to accurately identify LI in English language learners once they use English 40% of the time or more. However, for children with high Spanish experience, more information about development and patterns of impairment is needed to positively identify LI.

English made easy, v.1 a new ESL approach learning English through pictures

CERN Document Server

Crichton, Jonathan

2015-01-01

This is a fun and userfriendly way to learn EnglishEnglish Made Easy is a breakthrough in English language learningimaginatively exploiting how pictures and text can work together to create understanding and help learners learn more productively. It gives beginner English learners easy access to the vocabulary, grammar and functions of English as it is actually used in a comprehensive range of social situations. Selfguided students and classroom learners alike will be delighted by the way they are helped to progress easily from one unit to the next, using a combina

Poly(3-Hydroxybutyrate) Synthesis Genes in Azotobacter sp. Strain FA8

OpenAIRE

Pettinari, M. Julia; Vázquez, Gustavo J.; Silberschmidt, Daniel; Rehm, Bernd; Steinbüchel, Alexander; Méndez, Beatriz S.

2001-01-01

Genes responsible for the synthesis of poly(3-hydroxybutyrate) (PHB) in Azotobacter sp. FA8 were cloned and analyzed. A PHB polymerase gene (phbC) was found downstream from genes coding for β-ketothiolase (phbA) and acetoacetyl-coenzyme A reductase (phbB). A PHB synthase mutant was obtained by gene inactivation and used for genetic studies. The phbC gene from this strain was introduced into Ralstonia eutropha PHB-4 (phbC-negative mutant), and the recombinant accumulated PHB when either glucos...

Structurations formelle et conceptuelle des articles de dictionnaires : le premier modèle de codification des articles dans l’histoire des dictionnaires Larousse

Directory of Open Access Journals (Sweden)

Corbin Pierre

2014-07-01

Nous nous proposons d’examiner, dans l’histoire des dictionnaires généraux monolingues Larousse des origines à nos jours, une sélection de jalons de l’articulation entre structure conceptuelle et structure formelle des articles. Au regard de l’ampleur des données à couvrir, il ne pourra bien entendu s’agir que d’un survol, mais celui-ci permettra (1 de présenter le premier des trois modèles majeurs de codification des articles dans l’histoire des dictionnaires Larousse, celui qui trouve son origine dans le Nouveau dictionnaire de la langue française de 1856 ou ses éditions révisées, (2 de prendre en compte les dictionnaires proposés par cet éditeur en un siècle et demi qui ont repris le modèle de 1856 ou sa forme révisée, et (3 de présenter contrastivement au premier les deux autres modèles majeurs, qui trouvent leur ancrage chronologique respectivement dans le Grand dictionnaire universel du XIXe siècle de 1866-1876 et le Dictionnaire du français contemporain de 1966.

Teaching English for Specific Purposes

Directory of Open Access Journals (Sweden)

Nijolė Netikšienė

2011-04-01

Full Text Available Teaching English for Specific Purposes and General English is analysed in the article. The scientific approach of a scientist M. Rosenberg is presented. The experience of teaching English for Specific Purposesat VGTU is alsopresented. The ideas and teaching methods from the classes of general English can be transferred to the classes of English for Specific Purposes.

English Training

CERN Multimedia

2003-01-01

General and Professional English Courses The next session will take place: from 03 March to 28 June 2003 (2 weeks break at Easter). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel.73127 or Mr. Liptow: tel.72957. Writing Professional Documents in English This course is designed for people with a good level of spoken English. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Mrs. Tessa Osborne: Tessa.Osborne@cern. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, rol...

English Training

CERN Multimedia

2003-01-01

General and Professional English Courses The next session will take place: from 03 March to 28 June 2003 (2 weeks break at Easter). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel.73127 or Mr. Liptow: tel.72957. Writing Professional Documents in English This course is designed for people with a good level of spoken English. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Mrs. Tessa Osborne: Tessa.Osborne@cern. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-p...

A Study of Effective Strategies to Stimulate College Non-English Majors' Motivation for Learning English

Institute of Scientific and Technical Information of China (English)

向玉

2008-01-01

As an English teacher for non-English majors in a college in Wuhan,I find that most of my students are not interested in learning English.Thus.I am concerned about how to stimulate my students' motivation in learning English.This paper discusses some effective strategies to stimulate college non-English majors' motivation for learning English.such as creating a comfortable atmosphere,buiIding students' confidence,promoting cooperative learning.and incorporating the multiple intelligences concept in the classroom.These strategies do have practical application in my classroom and have motivated my students' interest in English learning.

FaQR, required for the biosynthesis of the strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone, encodes an enone oxidoreductase.

Science.gov (United States)

Raab, Thomas; López-Ráez, Juan Antonio; Klein, Dorothée; Caballero, Jose Luis; Moyano, Enriqueta; Schwab, Wilfried; Muñoz-Blanco, Juan

2006-04-01

The flavor of strawberry (Fragaria x ananassa) fruit is dominated by an uncommon group of aroma compounds with a 2,5-dimethyl-3(H)-furanone structure. We report the characterization of an enzyme involved in the biosynthesis of 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF; Furaneol), the key flavor compound in strawberries. Protein extracts were partially purified, and the observed distribution of enzymatic activity correlated with the presence of a single polypeptide of approximately 37 kD. Sequence analysis of two peptide fragments showed total identity with the protein sequence of a strongly ripening-induced, auxin-dependent putative quinone oxidoreductase, Fragaria x ananassa quinone oxidoreductase (FaQR). The open reading frame of the FaQR cDNA consists of 969 bp encoding a 322-amino acid protein with a calculated molecular mass of 34.3 kD. Laser capture microdissection followed by RNA extraction and amplification demonstrated the presence of FaQR mRNA in parenchyma tissue of the strawberry fruit. The FaQR protein was functionally expressed in Escherichia coli, and the monomer catalyzed the formation of HDMF. After chemical synthesis and liquid chromatography-tandem mass spectrometry analysis, 4-hydroxy-5-methyl-2-methylene-3(2H)-furanone was confirmed as a substrate of FaQR and the natural precursor of HDMF. This study demonstrates the function of the FaQR enzyme in the biosynthesis of HDMF as enone oxidoreductase and provides a foundation for the improvement of strawberry flavor and the biotechnological production of HDMF.

Diagnostic features of English-lexified creoles: First attestations from Virgin Islands English Creole

OpenAIRE

Andrei A. Avram

2011-01-01

This paper presents the earliest attestations in Virgin Islands English Creole of the diagnostic features of English-lexified contact languages proposed by Baker and Huber (2001). It compares the distribution of these features in Virgin Islands English Creole and in the seven Atlantic English-lexified pidgins and creoles considered by Baker and Huber (2001). Also included is a discussion of a number of selected features.

English made easy volume one a new ESL approach learning English through pictures

CERN Document Server

Crichton, Jonathan

2015-01-01

This is a fun and user–friendly way to learn English English Made Easy is a breakthrough in English language learning—imaginatively exploiting how pictures and text can work together to create understanding and help learners learn more productively. It gives beginner English learners easy access to the vocabulary, grammar and functions of English as it is actually used in a comprehensive range of social situations. Self–guided students and classroom learners alike will be delighted by the way they are helped to progress easily from one unit to the next, using a combination of pictures and text

English Speech Acquisition in 3- to 5-Year-Old Children Learning Russian and English

Science.gov (United States)

Gildersleeve-Neumann, Christina E.; Wright, Kira L.

2010-01-01

Purpose: English speech acquisition in Russian-English (RE) bilingual children was investigated, exploring the effects of Russian phonetic and phonological properties on English single-word productions. Russian has more complex consonants and clusters and a smaller vowel inventory than English. Method: One hundred thirty-seven single-word samples…

Hong Kong English: phonological features

Directory of Open Access Journals (Sweden)

Irina-Ana Drobot

2008-01-01

Full Text Available The aim of the paper is to present phonological features of Hong Kong English, which is a variety of New English. I examine features of the sound system (vowel and consonantal systems, characteristics of stress, rhythm, intonation, and phonological processes of the English spoken by Hongkongers. The way in which the accent and characteristics of the Hong Kong variety of English differs from standard, RP English is pointed out. Influences of Chinese and Cantonese on the phonological features of Hong Kong English are noticeable

Thermal Performance of Ventilated Double Skin Façades with Venetian Blinds

Directory of Open Access Journals (Sweden)

Jordi Parra

2015-05-01

Full Text Available Venetian blinds (VB are shading devices of widespread use in residential and corporate buildings. They can reflect or transmit light into buildings and at the same time allow daylighting and exterior views. They can also efficiently block radiative heat from entering the building, and if combined with a heat dissipation system such as forced ventilation, they can improve the thermal performance of double skin façades (DSF. Computational Fluid Dynamics (CFD has proven to be a useful tool for modeling flow and heat transfer in DSF, including conduction, convection and radiation heat transfer phenomena. The aim of this work is to evaluate, by means of CFD, the influence of several optical, construction and operation parameters of a DSF (such as optical properties of the materials, geometrical relations of the VB or flow stream conditions in terms of energy savings, measured as a reduction of the solar load entering the building. Results obtained show that parameters such as the proximity of the VB to the exterior skin of the façade or a differentiated surface treatment for the exterior and interior faces of the VB louvers can notably affect the thermal performance of the DSF and hence the heat gains experienced by the building.

Similarity Theory Based Radial Turbine Performance and Loss Mechanism Comparison between R245fa and Air for Heavy-Duty Diesel Engine Organic Rankine Cycles

Directory of Open Access Journals (Sweden)

Lei Zhang

2017-01-01

Full Text Available Organic Rankine Cycles using radial turbines as expanders are considered as one of the most efficient technologies to convert heavy-duty diesel engine waste heat into useful work. Turbine similarity design based on the existing air turbine profiles is time saving. Due to totally different thermodynamic properties between organic fluids and air, its influence on turbine performance and loss mechanisms need to be analyzed. This paper numerically simulated a radial turbine under similar conditions between R245fa and air, and compared the differences of the turbine performance and loss mechanisms. Larger specific heat ratio of air leads to air turbine operating at higher pressure ratios. As R245fa gas constant is only about one-fifth of air gas constant, reduced rotating speeds of R245fa turbine are only 0.4-fold of those of air turbine, and reduced mass flow rates are about twice of those of air turbine. When using R245fa as working fluid, the nozzle shock wave losses decrease but rotor suction surface separation vortex losses increase, and eventually leads that isentropic efficiencies of R245fa turbine in the commonly used velocity ratio range from 0.5 to 0.9 are 3%–4% lower than those of air turbine.

Diffusion tensor MRI tractography reveals increased fractional anisotropy (FA) in arcuate fasciculus following music-cued motor training.

Science.gov (United States)

Moore, Emma; Schaefer, Rebecca S; Bastin, Mark E; Roberts, Neil; Overy, Katie

2017-08-01

Auditory cues are frequently used to support movement learning and rehabilitation, but the neural basis of this behavioural effect is not yet clear. We investigated the microstructural neuroplasticity effects of adding musical cues to a motor learning task. We hypothesised that music-cued, left-handed motor training would increase fractional anisotropy (FA) in the contralateral arcuate fasciculus, a fibre tract connecting auditory, pre-motor and motor regions. Thirty right-handed participants were assigned to a motor learning condition either with (Music Group) or without (Control Group) musical cues. Participants completed 20minutes of training three times per week over four weeks. Diffusion tensor MRI and probabilistic neighbourhood tractography identified FA, axial (AD) and radial (RD) diffusivity before and after training. Results revealed that FA increased significantly in the right arcuate fasciculus of the Music group only, as hypothesised, with trends for AD to increase and RD to decrease, a pattern of results consistent with activity-dependent increases in myelination. No significant changes were found in the left ipsilateral arcuate fasciculus of either group. This is the first evidence that adding musical cues to movement learning can induce rapid microstructural change in white matter pathways in adults, with potential implications for therapeutic clinical practice. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Diagnostic features of English-lexified creoles: first attestations from Virgin Islands English creole

Directory of Open Access Journals (Sweden)

Andrei A. Avram

2011-11-01

Full Text Available This paper presents the earliest attestations in Virgin Islands English Creole of the diagnostic features of English-lexified contact languages proposed by Baker and Huber (2001. It compares the distribution of these features in Virgin Islands English Creole and in the seven Atlantic English-lexified pidgins and creoles considered by Baker and Huber (2001. Also included is a discussion of a number of selected features.

Diagnostic features of English-lexified creoles: First attestations from Virgin Islands English Creole

Directory of Open Access Journals (Sweden)

Andrei A. Avram

2011-01-01

Full Text Available This paper presents the earliest attestations in Virgin Islands English Creole of the diagnostic features of English-lexified contact languages proposed by Baker and Huber (2001. It compares the distribution of these features in Virgin Islands English Creole and in the seven Atlantic English-lexified pidgins and creoles considered by Baker and Huber (2001. Also included is a discussion of a number of selected features.

Experimental comparison of R123 and R245fa as working fluids for waste heat recovery from heavy-duty diesel engine

International Nuclear Information System (INIS)

Shu, Gequn; Zhao, Mingru; Tian, Hua; Huo, Yongzhan; Zhu, Weijie

2016-01-01

Organic Rankine Cycle (ORC) on-board is a solution for vehicles to save energy and reduce emission. Considering the characteristics of waste heat from vehicle, the criterions of the suitable working fluid are very strict. R123 and R245fa have been widely used in companies and labs, however, the difference of their properties under different engine conditions still requires further study. During this research, a series of experiments have been done to compare the performance of these two working fluids, what's more, to determine under which engine conditions they are suitable separately. These experimental comparisons are new and important for the targeting design of ORC for vehicles. The result shows that, considering the difference of thermodynamic properties and the limited cooling capacity on board, R123 shows its advantage for the waste heat recovery at heavy duty, while R245fa is more suitable at light-and-medium duty. These properties make R123 suitable for the ORC designed for long-haul heavy-duty truck, while R245fa is suggested for city bus. The following performance test of R123 for waste heat recovery from heavy-duty diesel engine shows that the maximum fuel consumption improvement can be as much as 2.8%. - Highlights: • R123 is more suitable for heavy duty and steady working condition. • R245fa shows its advantage at light-and-medium duty and varying working condition. • R123 suits better for long-haul heavy-duty truck, while R245fa for city bus. • The maximum fuel consumption improvement is as much as 2.8%.

Research on the Relationship between English Majors’ Learning Motivation and Spoken English in Chinese Context

Institute of Scientific and Technical Information of China (English)

陆佳佳

2014-01-01

With the increasing importance attached to spoken English, it is of great significance to find how the motivation of English majors affects their oral English learning outcomes. Based on the research results and theoretical frameworks of the previous studies on this area, this paper carries out research in Zhujiang College of South China Agricultural University trying to find out the types of motivation and the correlation between motivation factors of English majors and their spoken English, and thus to guide spoken English learning and teaching.

English and Tok Pisin (New Guinea Pidgin English) in Papua New Guinea.

Science.gov (United States)

Romaine, Suzanne

1989-01-01

Tok Pisin, New Guinea Pidgin English, is becoming increasingly important as a "lingua franca" in Papua New Guinea, even though English is the country's official language. Urban versus rural and spoken versus written varieties of the pidgin are examined, and the influence of English on Tok Pisin is investigated. 73 references. (Author/CB)

The non-English major lecturers speak English: The barriers encountered by adult learners

Directory of Open Access Journals (Sweden)

Ahmad Madkur

2018-03-01

Full Text Available This study was aimed at investigating the difficulties and problems faced by non-English major lecturers when they were taking a part in English discussion. This study was a qualitative descriptive research involving 10 non-English major lecturers who took a part in a twice-a-week discussion so-called English Corner. To collect the data, in-depth interview and observation were used. The collected data were analyzed by using Miles and Huberman’s interactive data analysis data model consisting of data reduction, data display and data verifying. The result of the study showed that those barriers could be classified into three problems namely socio-cultural, linguistic and interpersonal problems. The found barriers were expected to be a consideration to find out the solution to make the betterment of English learning among lecturers with the non-English background of study.

INFLUENCE OF STUDENT ENGLISH UTILITY AND TEACHER EFFICACY ON ENGLISH PROFICIENCY OF HIGH SCHOOL STUDENTS

Directory of Open Access Journals (Sweden)

Ruth A. ORTEGA-DELA CRUZ

2016-12-01

Full Text Available Learning second language considers a number of factors that influence the manner in which the language is taught. Understanding of the learners’ goals and motivation for learning is one. Using descriptive-correlational research design, this study determined the influence of student English utility and teacher efficacy on the students’ English proficiency. A total of 101 students from first year to fourth year level served as the respondents of the study. The study quantified the students’ perception towards English utility and their evaluation of English teacher efficacy which employed a researcher-made survey questionnaire. Results revealed high positive perceptions of students towards English utility. Analysis of variance revealed significant differences in the perceptions of high school students on the efficacy of their English teachers. Correlation coefficients indicated a positive linear relationship among the given variables. The p-value revealed significant relationship of teacher efficacy (r = .691, p-value = .000 and English utility (r = .467, p-value = .000 to students’ English proficiency. Results of regression statistics revealed that English utility has no significant influence on the student English proficiency. Therefore, the main factor that must still be considered then should be the teacher. Finally, there is an explicit indication that high level of teachers’ efficacy performing in teaching has much powerful influence on the English proficiency of high school students. Thus improving the methods of teaching English provides a better way of motivating students to achieve higher levels of proficiency in the future.

Motivation of Students’ English Learning and Its Implications for English Teaching

Institute of Scientific and Technical Information of China (English)

张亚莉

2016-01-01

As is well-known, people’s behaviors come from certain motivation. The learning of English also related to this certain motivation. The stronger the motivation is, the better effects on English learning students will have. If English teachers have a comprehensive understanding of the types and effects of the motivation, it will be useful for them to adjust their teaching methods to stimulate and sustain the students’ motivation.

THE ROLE OF NON-NATIVE ENGLISH SPEAKER TEACHERS IN ENGLISH LANGUAGE LEARNING

Directory of Open Access Journals (Sweden)

Lutfi Ashar Mauludin

2017-04-01

Full Text Available Native-English Speaker Teachers (NESTs and Non-Native English Speaker Teachers (NNESTs have their own advantages and disadvantages. However, for English Language Learners (ELLs, NNESTs have more advantages in helping students to acquire English skills. At least there are three factors that can only be performed by NNESTs in English Language Learning. The factors are knowledge of the subject, effective communication, and understanding students‘ difficulties/needs. The NNESTs can effectively provide the clear explanation of knowledge of the language because they are supported by the same background and culture. NNESTs also can communicate with the students with all levels effectively. The use of L1 is effective to help students building their knowledge. Finally, NNESTs can provide the objectives and materials that are suitable with the needs of the students.

FMRFamide-related peptides (FaRPs): A new family of peptides from amphibian defensive skin secretions

DEFF Research Database (Denmark)

Wang, Lei; Smyth, Anita; Johnsen, Anders

2009-01-01

amide (EF-10 amide), from the defensive skin secretions of two different species of African hyperoliid frogs, Kassina maculata and Phylictimantis verrucosus, respectively. These represent the first canonical FMRF amide-related peptides (FaRPs) from a vertebrate source. The cDNA encoding IF-8 amide...

English courses

CERN Multimedia

HR Department

2010-01-01

New courses University of Cambridge ESOL examination course We will be starting two new courses in October leading to the Cambridge First Certificate in English (level B2 of the European Framework) and the Cambridge Advanced English (level C1) examinations. These courses will consist of two semesters of 15 weeks with two two-hourly classes per week. There will be an average of eight students per class. Normally the examination will be taken in June 2011 but strong participants could take it earlier. People wishing to take these courses should enrol: http://cta.cern.ch/cta2/f?p=110:9:1927376177842004::NO::X_COURSE_ID,X_STATUS:4133%2CD and they will then be required to take a placement test to check that their level of English is of an appropriate level. Please note that we need a minimum of seven students enrolled to open a session. For further information please contact Tessa Osborne 72957. General and Professional English Courses The next session will take place: From 4th October 2010 to 5th Feb...

Operation characteristic and performance comparison of organic Rankine cycle (ORC) for low-grade waste heat using R245fa, R123 and their mixtures

International Nuclear Information System (INIS)

Feng, Yong-qiang; Hung, Tzu-Chen; He, Ya-Ling; Wang, Qian; Wang, Shuang; Li, Bing-xi; Lin, Jaw-Ren; Zhang, Wenping

2017-01-01

Highlights: • Experimental comparison using R123, R245fa and their mixtures has been investigated. • The basic operation parameters and the detailed operation characteristics of pure and mixture working fluids are addressed. • The mixture owns a relatively higher pump power consumption, 10–50% higher than that of R245fa and 2–47% higher than that of R123. • The highest system generating efficiency of 4.53% is obtained by 0.67R245fa/0.33R123. - Abstract: The operation characteristic and performance comparison of low-grade organic Rankine cycle (ORC) using R245fa, R123 and their mixtures have been investigated. The heat source temperature is set to be 120 °C, while the mass flow rate is controlled by adjusting the pump frequency. The basic operation parameters are first examined, while the detailed operation characteristics of pure and mixture working fluids are addressed. The system overall performance, including thermal efficiency and system generating efficiency, for pure and mixture working fluids are explored. The experimental results show that the mixtures own a relatively higher pump power consumption and enhancing the pump performance is also significant for ORC application. Whether the mixtures exhibit better thermodynamic performance than the pure working fluids depend on the operation parameters and mass fraction of mixtures. 0.67R245fa/0.33R123 owns the highest maximum net electricity output of 1.67 kW, 4.38% higher than that of R245fa and 63.73% higher than that of R123. Compared to the pure working fluids, the mixture working fluids own a better thermodynamic performance and a moderate economic performance.

Predictors and Outcomes of Early vs. Later English Language Proficiency Among English Language Learners

Science.gov (United States)

Halle, Tamara; Hair, Elizabeth; Wandner, Laura; McNamara, Michelle; Chien, Nina

2011-01-01

The development of English language learners (ELLs) was explored from kindergarten through eighth grade within a nationally representative sample of first-time kindergartners (N = 19,890). Growth curve analyses indicated that, compared to native English speakers, ELLs were rated by teachers more favorably on approaches to learning, self control, and externalizing behaviors in kindergarten and generally continued to grow in a positive direction on these social/behavioral outcomes at a steeper rate compared to their native English-speaking peers, holding other factors constant. Differences in reading and math achievement between ELLs and native English speakers varied based on the grade at which English proficiency is attained. Specifically, ELLs who were proficient in English by kindergarten entry kept pace with native English speakers in both reading and math initially and over time; ELLs who were proficient by first grade had modest gaps in reading and math achievement compared to native English speakers that closed narrowly or persisted over time; and ELLs who were not proficient by first grade had the largest initial gaps in reading and math achievement compared to native speakers but the gap narrowed over time in reading and grew over time in math. Among those whose home language is not English, acquiring English proficiency by kindergarten entry was associated with better cognitive and behavioral outcomes through eighth grade compared to taking longer to achieve proficiency. Multinomial regression analyses indicated that child, family, and school characteristics predict achieving English proficiency by kindergarten entry compared to achieving proficiency later. Results are discussed in terms of policies and practices that can support ELL children’s growth and development. PMID:22389551

INTERNATIONAL ENGLISH MANUAL

Energy Technology Data Exchange (ETDEWEB)

AMADOR, MABLE; KELLER, YVONNE KELLER

2002-02-22

This document presents a set of guidelines for authors who wish to express themselves more clearly to foreign readers, or readers whose first language is not American English. Topics include idioms, technical terms, jargon, word meaning, acronyms, and international conventions of measurement. The guidelines will help writers of technical documents present their ideas more effectively to audiences that may include individuals whose first language is not American English, including audiences with individuals from other English-speaking countries.

Nobody seems to speak English here today: Enhancing assessment and training in aviation English

Directory of Open Access Journals (Sweden)

Dan Douglas

2014-07-01

Full Text Available In 2003 the International Civil Aviation Organization (ICAO strengthened the provisions that English be made available for international radiotelephony communication. ICAO also developed standards for English proficiency for international pilots and air traffic controllers. However, these standards are applied variably from country to country and in no country are native speakers of English tested for their ability to employ what has been termed "interactional competence" when using English for intercultural communication. Problems with this situation are reviewed and suggestions made for improving English assessment and training.

The impact of teachers' limited English proficiency on English ...

African Journals Online (AJOL)

The importance of the role of language in teacher education programmes and in children's learning is crucial. This study focuses on the use of English as the language of learning and teaching and its impact on the language development of English second language (ESL) student teachers and ESL learners. Against the ...

Botswana English: Implications for English Language Teaching and Assessment

Science.gov (United States)

Alimi, Modupe

2011-01-01

Concerted efforts to characterise Botswana English (BE), though still referred to as "a variety in development", have validated its existence. However, the teaching and assessment of English in the high schools do not seem to have responded to the development of this variety. This paper discusses the viability of using Standard British…

MANOVA, LDA, and FA criteria in clusters parameter estimation

Directory of Open Access Journals (Sweden)

Stan Lipovetsky

2015-12-01

Full Text Available Multivariate analysis of variance (MANOVA and linear discriminant analysis (LDA apply such well-known criteria as the Wilks’ lambda, Lawley–Hotelling trace, and Pillai’s trace test for checking quality of the solutions. The current paper suggests using these criteria for building objectives for finding clusters parameters because optimizing such objectives corresponds to the best distinguishing between the clusters. Relation to Joreskog’s classification for factor analysis (FA techniques is also considered. The problem can be reduced to the multinomial parameterization, and solution can be found in a nonlinear optimization procedure which yields the estimates for the cluster centers and sizes. This approach for clustering works with data compressed into covariance matrix so can be especially useful for big data.

Language Growth in English Monolingual and Spanish-English Bilingual Children from 2.5 to 5 Years.

Science.gov (United States)

Hoff, Erika; Ribot, Krystal M

2017-11-01

To describe the trajectories of English and Spanish language growth in typically developing children from bilingual homes and compare those with the trajectories of English growth in children from monolingual homes, to assess effects of dual language exposure on language growth in typically developing children. Expressive vocabularies were assessed at 6-month intervals from age 30 to 60 months, in English for monolinguals and English and Spanish for bilinguals. Use of English and Spanish in the home was assessed via parental report. Multilevel modeling, including parent education as a covariate, revealed that children from bilingual homes lagged 6 months to 1 year behind monolingual children in English vocabulary growth. The size of the lag was related to the relative amount of English use in the home, but the relation was not linear. Increments in English use conferred the greatest benefit most among homes with already high levels of English use. These homes also were likely to have 1 parent who was a native English speaker. Bilingual children showed stronger growth in English than in Spanish. Bilingual children can lag 6 months to 1 year behind monolingual children in normal English language development. Such lags may not necessarily signify clinically relevant delay if parents report that children also have skills in the home language. Shorter lags are associated with 2 correlated factors: more English exposure and more exposure from native English speakers. Early exposure to Spanish in the home does not guarantee acquisition of Spanish. Copyright © 2017 Elsevier Inc. All rights reserved.

Hong Kong English: phonological features

OpenAIRE

Irina-Ana Drobot

2008-01-01

The aim of the paper is to present phonological features of Hong Kong English, which is a variety of New English. I examine features of the sound system (vowel and consonantal systems), characteristics of stress, rhythm, intonation, and phonological processes of the English spoken by Hongkongers. The way in which the accent and characteristics of the Hong Kong variety of English differs from standard, RP English is pointed out. Influences of Chinese and Cantonese on the phonological features ...

Sentential Negation in English

Science.gov (United States)

Mowarin, Macaulay

2009-01-01

This paper undertakes a detailed analysis of sentential negation in the English language with Chomsky's Government-Binding theory of Transformational Grammar as theoretical model. It distinguishes between constituent and sentential negation in English. The essay identifies the exact position of Negation phrase in an English clause structure. It…

Accident Testing of High Temperature Reactor Fuel Elements with the KueFA Device

International Nuclear Information System (INIS)

Seeger, O.; Laurie, M.; Bottomley, P.D.W.; Ferreira-Teixeira, A.E.; Van Winckel, S.; Rondinella, V.V.; Allelein, H.J.

2013-06-01

The High Temperature Reactor (HTR) is characterised by an advanced design with passive safety features. Fuel elements are constituted by a graphite matrix containing sub-mm-sized fuel particles with Tri-Isotropic (TRISO) coating, designed to provide high fission product retention. During a loss of coolant accident scenario in a HTR the maximum temperature is foreseen to be in the range of 1600-1650 deg. C, remaining well below the melting point of the fuel. The Cold Finger Apparatus (KueFA) is used to observe the combined effects of Depressurization and Loss of Forced Circulation (DLOFC) accident scenarios on HTR fuel. Originally designed at the Forschungszentrum Juelich (FZJ), an adapted KueFA operates on irradiated fuel in hot cell at JRC-ITU. A fuel pebble is heated in He atmosphere for several hundred hours, mimicking accident temperatures up to 1800 deg. C and realistic temperature transients. Non-gaseous volatile fission products released from the fuel condense on a water cooled stainless steel plate dubbed 'Cold Finger'. Exchanging plates frequently during the experiment and analysing plate deposits by means of HPGe gamma spectroscopy allows a reconstruction of the fission product release as a function of time and temperature. In order to achieve a good quantification of the release, a careful calibration of the setup is mandatory. An especially tailored collimator was designed to perform plate scanning with high spatial resolution, thus yielding information about the fission product distribution on the condensation plates. The analysis of condensation plates from recent KueFA tests shows that fission product release quantification is possible at high and low activity levels. Chemical dissolution has been performed for some condensation plates in order to assess beta nuclides of interest such as 90 Sr and possibly 129 I using an Inductively Coupled Plasma - Mass Spectrometer (ICP-MS) and to cross check the HPGe gamma spectroscopy measurements

FaCE: a tool for Three Body Faddeev calculations with core excitation

OpenAIRE

Thompson, I. J.; Nunes, F. M.; Danilin, B. V.

2004-01-01

FaCE is a self contained programme, with namelist input, that solves the three body Faddeev equations. It enables the inclusion of excitation of one of the three bodies, whilst the other two remain inert. It is particularly useful for obtaining the binding energies and bound state structure compositions of light exotic nuclei treated as three-body systems, given the three effective two body interactions. A large variety of forms for these interactions may be defined, and supersymmetric transf...

The Ideological Construction of English: A Critical Review on the Discourse of English in East Asia

Science.gov (United States)

Lin, Han-Yi

2014-01-01

This research investigates the ideological character of the English language in East Asia. It focuses on the prevailing beliefs, values and propositions relating to English as a global language and the spread of English in the non-English East Asian countries, namely China, Japan, South Korea and Taiwan. By analyzing how English is presented in…

“Is it English what we speak?” Irish English and Postcolonial Identity

Directory of Open Access Journals (Sweden)

Mariavita Cambria

2014-07-01

Full Text Available This paper explores the case of Ireland as an anti-litteram postcolonial context. Within this context, a main concern is that of the relationship between language and identity. Irish English (the variety of English spoken in Ireland enjoys a unique position within the constellation of world-wide English varieties. Various factors led to the emergence of Irish English, it may well have developed as a resistance to the (contrasting forces of colonialism and has been perceived as a different vehicle for communication when compared to received colonial English. Scholars now generally believe that Irish people, at a certain moment in time, decided to use a language which offered better possibilities for work. Via the analysis of some postcolonial issues, such as the linguistic crisis of the colonial subject, the paper will first illustrate the circumstances that led to the emergence of Irish English and then list the main features of this variety.

Attacking and defensive styles of play in soccer: analysis of Spanish and English elite teams.

Science.gov (United States)

Fernandez-Navarro, Javier; Fradua, Luis; Zubillaga, Asier; Ford, Paul R; McRobert, Allistair P

2016-12-01

The aim of this study was to define and categorise different styles of play in elite soccer and associated performance indicators by using factor analysis. Furthermore, the observed teams were categorised using all factor scores. Data were collected from 97 matches from the Spanish La Liga and the English Premier League from the seasons 2006-2007 and 2010-2011 using the Amisco® system. A total of 19 performance indicators, 14 describing aspects of attacking play and five describing aspects of defensive play, were included in the factor analysis. Six factors, representing 12 different styles of play (eight attacking and four defensive), had eigenvalues greater than 1 and explained 87.54% of the total variance. Direct and possession styles of play, defined by factor 1, were the most apparent styles. Factor analysis used the performance indicators to cluster each team's style of play. Findings showed that a team's style of play was defined by specific performance indicators and, consequently, teams can be classified to create a playing style profile. For practical implications, playing styles profiling can be used to compare different teams and prepare for opponents in competition. Moreover, teams could use specific training drills directed to improve their styles of play.

Teaching English Pronunciation of Suprasegmental Features on Students of English Education

Directory of Open Access Journals (Sweden)

Ahmad Yousef Bani

2018-01-01

Full Text Available The objective of this research is to know the technique and activity in teaching English pronunciation on suprasegmental features (intonation and stress. This research uses qualitative approach with descriptive method. The subject of this research is 6 students from English education department. Technique of collecting data by doing observation, interview and documentation. The results showed In teaching English pronunciation for suprasegmental features is very concerned about the how to teach students, give materials and do exercises. There are some materials that are taught to improve students' ability in stress words of English sentences. Students learnt combination of words adjectives and nouns are generally stressed is in the first, students are taught about the prefix, learnt about words with suffixes and students were also given exercise with compound words. Furthermore, in teaching intonation, students are also given understanding and practicing the reading text, analyzing and pronouncing the English word in accordance with the correct intonation. The impact, students understand how to use rising and falling intonation.

Obesity is accompanied by disturbances in peripheral glucocorticoid metabolism and changes in FA recycling

DEFF Research Database (Denmark)

Simonyte, Kotryna; Rask, Eva; Näslund, Ingmar

2009-01-01

and activity of 11betaHSD1 as well as the expression of phosphoenolpyruvate carboxykinase (PEPCK), sterol regulatory element binding protein (SREBP), and fatty acid synthase (FAS) in adipose and liver and investigated putative associations between 11betaHSD1 and energy metabolism genes. A total of 33 obese...... acid (FA) recycling in adipose tissue (AT)....

English Teaching in Mexico.

Science.gov (United States)

Salazar, Denise

2002-01-01

Discusses teaching English in Mexico, a country with important social, cultural, and economic ties to the United States. Looks at the various English teaching situations as well as teacher education for teachers in Mexico. Concludes that the English teaching situation in Mexico reflects great diversity and growth, and that the knowledge of English…

Maori English

Science.gov (United States)

Maclagan, Margaret; King, Jeanette; Gillon, Gail

2008-01-01

The Maori language is the language of the indigenous people of New Zealand. Today, not all Maori speak the Maori language, and many Maori as well as non-Maori speak Maori English, the fastest growing of the main varieties of New Zealand English. This paper provides a background to the linguistic situation of the Maori populace in New Zealand,…

Effective instruction for English learners.

Science.gov (United States)

Calderón, Margarita; Slavin, Robert; Sánchez, Marta

2011-01-01

The fastest-growing student population in U.S. schools today is children of immigrants, half of whom do not speak English fluently and are thus labeled English learners. Although the federal government requires school districts to provide services to English learners, it offers states no policies to follow in identifying, assessing, placing, or instructing them. Margarita Calderón, Robert Slavin, and Marta Sánchez identify the elements of effective instruction and review a variety of successful program models. During 2007-08, more than 5.3 million English learners made up 10.6 percent of the nation's K-12 public school enrollment. Wide and persistent achievement disparities between these English learners and English-proficient students show clearly, say the authors, that schools must address the language, literacy, and academic needs of English learners more effectively. Researchers have fiercely debated the merits of bilingual and English-only reading instruction. In elementary schools, English learners commonly receive thirty minutes of English as a Second Language (ESL) instruction but attend general education classes for the rest of the day, usually with teachers who are unprepared to teach them. Though English learners have strikingly diverse levels of skills, in high school they are typically lumped together, with one teacher to address their widely varying needs. These in-school factors contribute to the achievement disparities. Based on the studies presented here, Calderón, Slavin, and Sánchez assert that the quality of instruction is what matters most in educating English learners. They highlight comprehensive reform models, as well as individual components of these models: school structures and leadership; language and literacy instruction; integration of language, literacy, and content instruction in secondary schools; cooperative learning; professional development; parent and family support teams; tutoring; and monitoring implementation and outcomes

Navajo-English Dictionary.

Science.gov (United States)

Wall, Leon; Morgan, William

A brief summary of the sound system of the Navajo language introduces this Navajo-English dictionary. Diacritical markings and an English definition are given for each Navajo word. Words are listed alphabetically by Navajo sound. (VM)

Thinking of English Quality Education

Institute of Scientific and Technical Information of China (English)

袁捷

2012-01-01

On the suggestions of advancing quality-oriented education actively, the State Education Commission made detailed explanation to Chinese quality education: Quality Education is education taking improv- ing whole nation’s quality as its aim. With the high-speed development of economy, quality education, especially English quality education, is out of line from development in our country. Thus, based on the current situation of English Quality Education, it deserves our attention of Secondary Vocational English Quality Education on English quality, English quality education, principles and strategies.

English Language Teaching Profile: Sweden.

Science.gov (United States)

British Council, London (England). English-Teaching Information Centre.

This profile in outline form of the English language teaching situation in Sweden discusses the role of English within Swedish society and within the Swedish educational system. The status of English as the principal foreign language since 1945 for use in business, the media and tourism is pointed out. The system of English instruction in the…

My Hesitation to Speak English

Science.gov (United States)

Oda, Naruha

2015-01-01

Even though English was the author's favorite subject, she was not good at speaking in English, and always tried to avoid it. However, it did not matter because she did not have to speak to demonstrate her English ability. After entering university, her lack of confidence in speaking English became a major issue, and other students face the same…

Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2

DEFF Research Database (Denmark)

Jensen, Charlotte Harken; Krogh, Thomas N; Højrup, Peter

1994-01-01

The present paper describes the primary structure, glycosylation and tissue localization of fetal antigen 1 (FA1) isolated from second-trimester human amniotic fluid. FA1 is a single-chained, heterogeneous glycoprotein of 225-262 amino acid residues. FA1 has six well conserved epidermal...... extends with minor corrections to the human adrenal-specific mRNA, pG2 as well. Immunohistochemical analysis demonstrated the presence of FA1 in 10 out of 14 lung tumors containing neuroendocrine elements, and in the placental villi where FA1 was exclusively seen in stromal cells in close contact...... to the vascular structure. In the pancreas, FA1 co-localized with insulin in the insulin secretory granules of the beta cells within the islets of Langerhans. Our findings suggest that FA1 is synthesized as a membrane anchored protein and released into the circulation after enzymic cleavage, and that circulating...

Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia

Directory of Open Access Journals (Sweden)

Kimberly A. Rickman

2015-07-01

Full Text Available Fanconi anemia (FA is a rare bone marrow failure and cancer predisposition syndrome resulting from pathogenic mutations in genes encoding proteins participating in the repair of DNA interstrand crosslinks (ICLs. Mutations in 17 genes (FANCA-FANCS have been identified in FA patients, defining 17 complementation groups. Here, we describe an individual presenting with typical FA features who is deficient for the ubiquitin-conjugating enzyme (E2, UBE2T. UBE2T is known to interact with FANCL, the E3 ubiquitin-ligase component of the multiprotein FA core complex, and is necessary for the monoubiquitination of FANCD2 and FANCI. Proband fibroblasts do not display FANCD2 and FANCI monoubiquitination, do not form FANCD2 foci following treatment with mitomycin C, and are hypersensitive to crosslinking agents. These cellular defects are complemented by expression of wild-type UBE2T, demonstrating that deficiency of the protein UBE2T can lead to Fanconi anemia. UBE2T gene gains an alias of FANCT.

Thermodynamic analysis and comparison between CO_2 transcritical power cycles and R245fa organic Rankine cycles for low grade heat to power energy conversion

International Nuclear Information System (INIS)

Li, L.; Ge, Y.T.; Luo, X.; Tassou, S.A.

2016-01-01

Highlights: • CO_2 is a promising working fluid to be applied in low-grade power generation systems. • Thermodynamic models of CO_2 transcritical power cycles (T-CO_2) and R245fa ORC were developed. • Energy and exergy analyses were carried out for T-CO_2 and R245fa ORC systems. • Optimal system designs are existed for both T-CO_2 and R245fa ORC systems. - Abstract: In this paper, a theoretical study is conducted to investigate and compare the performance of CO_2 transcritical power cycles (T-CO_2) and R245fa organic Rankine cycles (ORCs) using low-grade thermal energy to produce useful shaft or electrical power. Each power cycle consists of typical Rankine cycle components, such as a working fluid pump, gas generator or evaporator, turbine with electricity generator, air cooled condenser and recuperator (internal heat exchanger). The thermodynamic models of both cycles have been developed and are applied to calculate and compare the cycle thermal and exergy efficiencies at different operating conditions and control strategies. The simulation results show that the system performances for both cycles vary with different operating conditions. When the heat source (waste heat) temperature increases from 120 °C to 260 °C and heat sink (cooling air) temperature is reduced from 20 °C to 0 °C, both thermal efficiencies of R245fa ORC and T-CO_2 with recuperator can significantly increase. On the other hand, R245fa ORC and T-CO_2 exergy efficiencies increase with lower heat sink temperatures and generally decrease with higher heat source temperatures. In addition, with the same operating conditions and heat transfer assumptions, the thermal and exergy efficiencies of R245fa ORCs are both slightly higher than those of T-CO_2. However, the efficiencies of both cycles can be enhanced by installing a recuperator in each system at specified operating conditions. Ultimately, optimal operating states can be predicted, with particular focus on the working fluid expander

Attitudes toward English & English Learning at an Iranian Military University: A Preliminary Survey

Science.gov (United States)

Mahdavi Zafarghandi, Amir; Jodai, Hojat

2012-01-01

This study intends to represent attitudes toward English and English learning at an Iranian military university. Iranian military staff is required to study English in a social environment where there is little immediate need or opportunity to use the language for real communicative purposes.The subjects included 34 Iranian military personnel who…

Optimizing Client Latency in a Distributed System by Using the “Remote Façade” Design Pattern

Directory of Open Access Journals (Sweden)

Cosmin RABLOU

2010-01-01

Full Text Available In this paper we investigate the role of the Remote Façade pattern in the optimization of dis-tributed systems. The intent of this pattern is to wrap fine-grained remote objects in a coarse-grained interface and thus greatly reduce the total number of calls executed over the network. The measurement of the performance gain achieved by implementing this pattern is done through testing with a distributed application written in C# and using the latest Microsoft framework for distributed systems (Windows Communication Framework. Furthermore, we will be presenting the scenarios in which the implementation of the Remote Façade pattern brings a significant performance gain. Finally we show further scenarios in which the per-formance brought by this pattern can be investigated.

Teaching English or Producing Docility? Foucauldian Analysis of Pakistani State-Mandated English Textbooks

Science.gov (United States)

Channa, Liaquat Ali; Gilhooly, Daniel; Channa, Abdul Razaque; Manan, Syed Abdul

2017-01-01

The scholarship of language education, particularly with reference to learning and use of English, is marked by varieties of English. One may note two broad models: (1) ENL, ESL, and EFL; (2) EIL, ELF, and WEs. Although the scholarship is replete with debates, the debates seem to only construct and maintain that learning English and its use are…

Linguistic Characteristics of Advertising English

Institute of Scientific and Technical Information of China (English)

易高燕

2010-01-01

Advertising language takes form under the influence of linguistics,psychology and sociology,etc,and its way of choosing words and building sentences are quite different from normal English.And as a practical language,advertising English has its specific functions,and it has been distinguished from normal English as an independent language,and it has plentiful values.This paper aims to discuss some linguistic characteristics of advertising English.

THE BASIC SPECIFICITY OF THE ABILITY OF VARIED ENGLISH LANGUAGE CURRICULUMS TO ENHANCE ENGLISH LEARNERS' CAPACITY TO DEVELOP NECESSARY SKILLS TO COMMUNICATE USING THE ENGLISH LANGUAGE

OpenAIRE

Michael Wayne Hendershot; Nutprapha K. Dennis; Suchada Chaiwiwattrakul; Ratirot Phiphitphakdee

2017-01-01

Inasmuch as the goal of teaching English to non-native English speakers should be focused on enhancing English learners’ ability to develop skills necessary for efficient and effective use of the English language in communication within their daily lives as well as within the context of educational, employment, governmental, and business related issues, the materials and resources used by the teacher to provide said English learners with enhanced ability to develop necessary skills for the us...

Figlina u Fažani i njezina preobrazba u kasnoj antici

OpenAIRE

Bulić, Davor; Koncani Uhač, Ida

2011-01-01

Figlina u Fažani prvi se put spominje u stručnoj literaturi početkom XX. stoljeća. Proučavanje proizvoda i njihove distribucije na tržište te pitanje vlasništva figline intenzivira se kroz zadnja tri desetljeća prošlog stoljeća. Zaštitna arheološka istraživanja (2007. - 2009.) omogućila su prikupljanje više ili manje cjelovitih podataka o mikrolokaciji radioničkog kompleksa i keramičkih proizvoda. Ovaj prilog predstavlja pokušaj sistematizacije dostupnih podataka i njihov...

English speech acquisition in 3- to 5-year-old children learning Russian and English.

Science.gov (United States)

Gildersleeve-Neumann, Christina E; Wright, Kira L

2010-10-01

English speech acquisition in Russian-English (RE) bilingual children was investigated, exploring the effects of Russian phonetic and phonological properties on English single-word productions. Russian has more complex consonants and clusters and a smaller vowel inventory than English. One hundred thirty-seven single-word samples were phonetically transcribed from 14 RE and 28 English-only (E) children, ages 3;3 (years;months) to 5;7. Language and age differences were compared descriptively for phonetic inventories. Multivariate analyses compared phoneme accuracy and error rates between the two language groups. RE children produced Russian-influenced phones in English, including palatalized consonants and trills, and demonstrated significantly higher rates of trill substitution, final devoicing, and vowel errors than E children, suggesting Russian language effects on English. RE and E children did not differ in their overall production complexity, with similar final consonant deletion and cluster reduction error rates, similar phonetic inventories by age, and similar levels of phonetic complexity. Both older language groups were more accurate than the younger language groups. We observed effects of Russian on English speech acquisition; however, there were similarities between the RE and E children that have not been reported in previous studies of speech acquisition in bilingual children. These findings underscore the importance of knowing the phonological properties of both languages of a bilingual child in assessment.

Algae façade as green building method: application of algae as a method to meet the green building regulation

Science.gov (United States)

Poerbo, Heru W.; Martokusumo, Widjaja; Donny Koerniawan, M.; Aulia Ardiani, Nissa; Krisanti, Susan

2017-12-01

The Local Government of Bandung city has stipulated a Green Building regulation through the Peraturan Walikota Number 1023/2016. Signed by the mayor in October 2016, Bandung became the first city in Indonesia that put green building as mandatory requirement in the building permit (IMB) process. Green Building regulation is intended to have more efficient consumption of energy and water, improved indoor air quality, management of liquid and solid waste etc. This objective is attained through various design method in building envelope, ventilation and air conditioning system, lighting, indoor transportation system, and electrical system. To minimize energy consumption of buildings that have large openings, sun shading device is often utilized together with low-E glass panes. For buildings in hot humid tropical climate, this method reduces indoor air temperature and thus requires less energy for air conditioning. Indoor air quality is often done by monitoring the carbon dioxide levels. Application of algae as part of building system façade has recently been introduced as replacement of large glass surface in the building façade. Algae are not yet included in the green building regulation because it is relatively new. The research will investigate, with the help of the modelling process and extensive literature, how effective is the implementation of algae in building façade to reduce energy consumption and improve its indoor air quality. This paper is written based on the design of ITB Innovation Park as an ongoing architectural design-based research how the algae-integrated building façade affects the energy consumption.

Status and prospects of the FaCT project

International Nuclear Information System (INIS)

Nagaoki, Yoshihiro; Kikuchi, Shin; Ichimiya, Masakazu

2008-01-01

'Fast Reactor Cycle Technology Development (FaCT)' project has been conducted since 2006. In this project, design study and research and development (R and D) on innovative technologies for fast reactor (FR) cycle system are implemented in order to present the conceptual designs of commercial and demonstration facilities by 2015 and start operating demonstration fast reactor in 2025. The R and Ds has been stepped forward into the development stage to establish the realization of innovative technologies which bring excellent performance to fast reactor cycle system. The purpose of R and D by 2010 is to decide whether innovative technologies shall be adopted. So promoting R and D of FR, the project governance was organized. Furthermore, several possible R and D have been effectively carried out within the frameworks of international cooperation, such as Global Nuclear Energy Partnership (GNEP), Generation IV International Forum (GIF), and International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). (author)

Media Representations of Older Adults from 2000-2015

DEFF Research Database (Denmark)

Iversen, Sara Mosberg; Wilinska, Monika

to the representation of older adults. The review encompasses 192 research articles found in the databases Academic Search Premiere, Communication Source, SOCindex and Scopus. The criteria for inclusion were that the articles should be in English, published between 2000-2015 in a scholarly, peer-reviewed journal...

An Introduction to English Teaching, A Textbook for English Educators

Science.gov (United States)

Lin, Grace Hui Chin; Chien, Paul Shih-chieh

2010-01-01

Teaching English became a professional and academic field from a half century ago. Many researches for teacher education and teacher training have been conducted in order to raise the English as well as the foreign language trainers' knowledge and capabilities in carrying out effective lessons in classroom. During second millennium of speedily…

Nineteenth-Century English

DEFF Research Database (Denmark)

Fabricius, Anne

2009-01-01

The article reviews the book "Nineteenth-Century English: Stability and Change," by Merja Kytö, Mats Rydèn and Erik Smitterberg......The article reviews the book "Nineteenth-Century English: Stability and Change," by Merja Kytö, Mats Rydèn and Erik Smitterberg...

Δ9-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: Possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells

International Nuclear Information System (INIS)

Takeda, Shuso; Ikeda, Eriko; Su, Shengzhong; Harada, Mari; Okazaki, Hiroyuki; Yoshioka, Yasushi; Nishimura, Hajime; Ishii, Hiroyuki; Kakizoe, Kazuhiro; Taniguchi, Aya; Tokuyasu, Miki; Himeno, Taichi; Watanabe, Kazuhito; Omiecinski, Curtis J.; Aramaki, Hironori

2014-01-01

We recently reported that Δ 9 -tetrahydrocannabinol (Δ 9 -THC), a major cannabinoid component in Cannabis Sativa (marijuana), significantly stimulated the expression of fatty acid 2-hydroxylase (FA2H) in human breast cancer MDA-MB-231 cells. Peroxisome proliferator-activated receptor α (PPARα) was previously implicated in this induction. However, the mechanisms mediating this induction have not been elucidated in detail. We performed a DNA microarray analysis of Δ 9 -THC-treated samples and showed the selective up-regulation of the PPARα isoform coupled with the induction of FA2H over the other isoforms (β and γ). Δ 9 -THC itself had no binding/activation potential to/on PPARα, and palmitic acid (PA), a PPARα ligand, exhibited no stimulatory effects on FA2H in MDA-MB-231 cells; thus, we hypothesized that the levels of PPARα induced were involved in the Δ 9 -THC-mediated increase in FA2H. In support of this hypothesis, we herein demonstrated that; (i) Δ 9 -THC activated the basal transcriptional activity of PPARα in a concentration-dependent manner, (ii) the concomitant up-regulation of PPARα/FA2H was caused by Δ 9 -THC, (iii) PA could activate PPARα after the PPARα expression plasmid was introduced, and (iv) the Δ 9 -THC-induced up-regulation of FA2H was further stimulated by the co-treatment with L-663,536 (a known PPARα inducer). Taken together, these results support the concept that the induced levels of PPARα may be involved in the Δ 9 -THC up-regulation of FA2H in MDA-MB-231 cells

Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells.

Science.gov (United States)

Takeda, Shuso; Ikeda, Eriko; Su, Shengzhong; Harada, Mari; Okazaki, Hiroyuki; Yoshioka, Yasushi; Nishimura, Hajime; Ishii, Hiroyuki; Kakizoe, Kazuhiro; Taniguchi, Aya; Tokuyasu, Miki; Himeno, Taichi; Watanabe, Kazuhito; Omiecinski, Curtis J; Aramaki, Hironori

2014-12-04

We recently reported that Δ(9)-tetrahydrocannabinol (Δ(9)-THC), a major cannabinoid component in Cannabis Sativa (marijuana), significantly stimulated the expression of fatty acid 2-hydroxylase (FA2H) in human breast cancer MDA-MB-231 cells. Peroxisome proliferator-activated receptor α (PPARα) was previously implicated in this induction. However, the mechanisms mediating this induction have not been elucidated in detail. We performed a DNA microarray analysis of Δ(9)-THC-treated samples and showed the selective up-regulation of the PPARα isoform coupled with the induction of FA2H over the other isoforms (β and γ). Δ(9)-THC itself had no binding/activation potential to/on PPARα, and palmitic acid (PA), a PPARα ligand, exhibited no stimulatory effects on FA2H in MDA-MB-231 cells; thus, we hypothesized that the levels of PPARα induced were involved in the Δ(9)-THC-mediated increase in FA2H. In support of this hypothesis, we herein demonstrated that; (i) Δ(9)-THC activated the basal transcriptional activity of PPARα in a concentration-dependent manner, (ii) the concomitant up-regulation of PPARα/FA2H was caused by Δ(9)-THC, (iii) PA could activate PPARα after the PPARα expression plasmid was introduced, and (iv) the Δ(9)-THC-induced up-regulation of FA2H was further stimulated by the co-treatment with L-663,536 (a known PPARα inducer). Taken together, these results support the concept that the induced levels of PPARα may be involved in the Δ(9)-THC up-regulation of FA2H in MDA-MB-231 cells. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Characteristics of an Effective English Language Teacher as Perceived by Iranian Teachers and Learners of English

Science.gov (United States)

Shishavan, Homa Babai; Sadeghi, Karim

2009-01-01

This study attempted to characterize qualities of an effective English language teacher (EELT) as perceived by Iranian English language teachers and learners. For this purpose, a tailor-made questionnaire was administered to 59 English language teachers and 215 learners of English at universities, high schools and language institutes in Iran. The…

The Yale Kamusi Project: A Swahili-English, English-Swahili Dictionary.

Science.gov (United States)

Hinnebusch, Thomas

2001-01-01

Evaluates the strengths and weaknesses of the Yale Online Kamusi project, an electronic Web-based Swahili-English and English-Swahili dictionary. The dictionary is described and checked for comprehensiveness, the adequacy and quality of the glosses and definitions are tested, and a number of recommendations are made to help make it a better and…

Climate Based Façade Design for Business Buildings with Examples from Central London

Directory of Open Access Journals (Sweden)

John Napier

2015-01-01

Full Text Available There is a disconnection between commercial architecture and environmental thinking, where green features can be included as part of a strategy for gaining approvals and marketing projects, but those features are not reviewed after completion and occupation of the building and knowledge is not shared. High levels of air conditioning are still considered unavoidable. Elaborate double skin façades and complex motorized shading systems are adopted; often masking an underlying lack of basic environmental thinking. This article returns (in principle to the physics of comfort in buildings and the passive strategies which can help achieve this with a low energy and carbon footprint. Passive and active façade design strategies are outlined as the basis of a critical tool and a design methodology for new projects. A new architectural sensibility can arise based on modeling the inputs of sunlight, daylight and air temperature in time and space at the early stages of design. Early but sound strategies can be tested and refined using advanced environmental modeling techniques. Architecture and environmental thinking can proceed hand in hand through the design process.

Which English? Whose English? An Investigation of "Non-Native" Teachers' Beliefs about Target Varieties

Science.gov (United States)

Young, Tony Johnstone; Walsh, Steve

2010-01-01

This study explored the beliefs of "non-native English speaking" teachers about the usefulness and appropriacy of varieties such as English as an International Language (EIL) and English as a Lingua Franca (ELF), compared with native speaker varieties. The study therefore addresses the current theoretical debate concerning "appropriate" target…

Attitudes towards English in Ghana

Directory of Open Access Journals (Sweden)

Kari Dako

2017-05-01

Full Text Available The paper considers official and individual attitudes towards bilingualism in English and a Ghanaian language. We ask whether bilingualism in English and Ghanaian languages is a social handicap, without merit, or an important indicator of ethnic identity. Ghana has about 50 non-mutually intelligible languages, yet there are no statistics on who speaks what language(s where in the country. We consider attitudes to English against the current Ghanaian language policy in education as practised in the school system. Our data reveal that parents believe early exposure to English enhances academic performance; English is therefore becoming the language of the home.

Test for English Majors (TEM) in China

Science.gov (United States)

Jin, Yan; Fan, Jinsong

2011-01-01

The purpose of the Test for English Majors (TEM) is to measure the English proficiency of Chinese university undergraduates majoring in English Language and Literature and to examine whether these students meet the required levels of English language abilities as specified in the National College English Teaching Syllabus for English Majors…

Standard English and Language Attitudes

OpenAIRE

ソランキ, ネイディン

2005-01-01

This paper investigates the attitudes and opinions surrounding Standard English (SE) within the United Kingdom. The definition of SE, for the purposes of this study, is standard grammar and standard pronunciation of southern English, commonly referred to as 'BBC English'. The subject of SE and attitudes towards different accents and dialects of British English is emotive and attracts strong opinions. The main issues discussed here are the place of language in society, the social implications ...

Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu).

Science.gov (United States)

Luan, Jinwei; Li, Xianglan; Guo, Rutao; Liu, Shanshan; Luo, Hongyu; You, Qingshan

2016-06-01

Next generation sequencing and bio-informatic analyses were conducted to investigate the mechanism of reactivation of p53 and induction of tumor cell apoptosis (RITA)-enhancing X-ray susceptibility in FaDu cells. The cDNA was isolated from FaDu cells treated with 0 X-ray, 8 Gy X-ray, or 8 Gy X-ray + RITA. Then, cDNA libraries were created and sequenced using next generation sequencing, and each assay was repeated twice. Subsequently, differentially expressed genes (DEGs) were identified using Cuffdiff in Cufflinks and their functions were predicted by pathway enrichment analyses. Genes that were constantly up- or down-regulated in 8 Gy X-ray-treated FaDu cells and 8 Gy X-ray + RITA-treated FaDu cells were obtained as RITA genes. Afterward, the protein-protein interaction (PPI) relationships were obtained from the STRING database and a PPI network was constructed using Cytoscape. Furthermore, ClueGO was used for pathway enrichment analysis of genes in the PPI network. Total 2,040 and 297 DEGs were identified in FaDu cells treated with 8 Gy X-ray or 8 Gy X-ray + RITA, respectively. PARP3 and NEIL1 were enriched in base excision repair, and CDK1 was enriched in p53 signaling pathway. RFC2 and EZH2 were identified as RITA genes. In the PPI network, many interaction relationships were identified (e.g., RFC2-CDK1, EZH2-CDK1 and PARP3-EZH2). ClueGO analysis showed that RFC2 and EZH2 were related to cell cycle. RFC2, EZH2, CDK1, PARP3 and NEIL1 may be associated, and together enhance the susceptibility of FaDu cells treated with RITA to the deleterious effects of X-ray.

Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu)

International Nuclear Information System (INIS)

Luan, Jinwei; Li, Xianglan; Guo, Rutao; Liu, Shanshan; Luo, Hongyu; You, Qingshan

2016-01-01

Next generation sequencing and bio-informatic analyses were conducted to investigate the mechanism of reactivation of p53 and induction of tumor cell apoptosis (RITA)-enhancing X-ray susceptibility in FaDu cells. The cDNA was isolated from FaDu cells treated with 0 X-ray, 8 Gy X-ray, or 8 Gy X-ray + RITA. Then, cDNA libraries were created and sequenced using next generation sequencing, and each assay was repeated twice. Subsequently, differentially expressed genes (DEGs) were identified using Cuffdiff in Cufflinks and their functions were predicted by pathway enrichment analyses. Genes that were constantly up- or down-regulated in 8 Gy X-ray-treated FaDu cells and 8 Gy X-ray + RITA-treated FaDu cells were obtained as RITA genes. Afterward, the protein-protein interaction (PPI) relationships were obtained from the STRING database and a PPI network was constructed using Cytoscape. Furthermore, ClueGO was used for pathway enrichment analysis of genes in the PPI network. Total 2,040 and 297 DEGs were identified in FaDu cells treated with 8 Gy X-ray or 8 Gy X-ray + RITA, respectively. PARP3 and NEIL1 were enriched in base excision repair, and CDK1 was enriched in p53 signaling pathway. RFC2 and EZH2 were identified as RITA genes. In the PPI network, many interaction relationships were identified (e.g., RFC2-CDK1, EZH2-CDK1 and PARP3-EZH2). ClueGO analysis showed that RFC2 and EZH2 were related to cell cycle. RFC2, EZH2, CDK1, PARP3 and NEIL1 may be associated, and together enhance the susceptibility of FaDu cells treated with RITA to the deleterious effects of X-ray

Simulation-based method to determine climatic energy strategies of an adaptable building retrofit façade system

International Nuclear Information System (INIS)

Capeluto, I. Guedi; Ochoa, Carlos E.

2014-01-01

Vast amounts of the European residential stock were built with limited consideration for energy efficiency, yet its refurbishment can help reach national energy reduction goals, decreasing environmental impact. Short-term retrofits with reduced interference to inhabitants can be achieved by upgrading facades with elements that enhance energy efficiency and user comfort. The European Union-funded Meefs Retrofitting (Multifunctional Energy Efficient Façade System) project aims to develop an adaptable mass-produced facade system for energy improvement in existing residential buildings throughout the continent. This article presents a simplified methodology to identify preferred strategies and combinations for the early design stages of such system. This was derived from studying weather characteristics of European regions and outlining climatic energy-saving strategies based on human thermal comfort. Strategies were matched with conceptual technologies like glazing, shading and insulation. The typical building stock was characterized from statistics of previous European projects. Six improvements and combinations were modelled using a simulation model, identifying and ranking preferred configurations. The methodology is summarized in a synoptic scheme identifying the energy rankings of each improvement and combination for the studied climates and façade orientations. - Highlights: • First results of EU project for new energy efficient façade retrofit system. • System consists of prefabricated elements with multiple options for flexibility. • Modular strategies were determined that adapt to different climates. • Technologies matching the strategies were identified. • Presents a method for use and application in different climates across Europe

Introducing English grammar

CERN Document Server

Borjars, Kersti

2013-01-01

Answering key questions such as 'Why study grammar?' and 'What is standard English?', Introducing English Grammar guides readers through the practical analysis of the syntax of English sentences. With all special terms carefully explained as they are introduced, the book is written for readers with no previous experience of grammatical analysis. It is ideal for all those beginning their study of linguistics, English language or speech pathology, as well as students with primarily literary interests who need to cover the basics of linguistic analysis. The approach taken is in line with current research in grammar, a particular advantage for students who may go on to study syntax in more depth. All the examples and exercises use real language taken from newspaper articles, non-standard dialects and include excerpts from studies of patients with language difficulties. Students are encouraged to think about the terminology as a tool kit for studying language and to test what can and cannot be described using thes...

School of Juridical English

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I. G. Fedotova

2014-01-01

Full Text Available The Department of English Language № 8 works with students of the Faculty of International Law. The unique school of teaching legal aspects of the English language is one of the most significant achievements of the department. Associate Professor V.F. Nazarov was one of professionals, was at the origin of this school. In 1992 the textbook "The course of the legal interpretation of Anglo-American Commercial Law" was published, which was the result of work of group of specialists in legal translation since early 1970s. The book laid foundation for the further development of the school of teaching legal aspects of the English language. After1990stheteaching of the legal aspects of English language was brought to the next level, marked of the by the creation of the educational complex "Legal concepts and categories in the English language" by I.G. Fedotova and G.P. Tolstopyatenko, based on the new competence-based concept of educating professional international lawyers.

Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.

Science.gov (United States)

Rickman, Kimberly A; Lach, Francis P; Abhyankar, Avinash; Donovan, Frank X; Sanborn, Erica M; Kennedy, Jennifer A; Sougnez, Carrie; Gabriel, Stacey B; Elemento, Olivier; Chandrasekharappa, Settara C; Schindler, Detlev; Auerbach, Arleen D; Smogorzewska, Agata

2015-07-07

Fanconi anemia (FA) is a rare bone marrow failure and cancer predisposition syndrome resulting from pathogenic mutations in genes encoding proteins participating in the repair of DNA interstrand crosslinks (ICLs). Mutations in 17 genes (FANCA-FANCS) have been identified in FA patients, defining 17 complementation groups. Here, we describe an individual presenting with typical FA features who is deficient for the ubiquitin-conjugating enzyme (E2), UBE2T. UBE2T is known to interact with FANCL, the E3 ubiquitin-ligase component of the multiprotein FA core complex, and is necessary for the monoubiquitination of FANCD2 and FANCI. Proband fibroblasts do not display FANCD2 and FANCI monoubiquitination, do not form FANCD2 foci following treatment with mitomycin C, and are hypersensitive to crosslinking agents. These cellular defects are complemented by expression of wild-type UBE2T, demonstrating that deficiency of the protein UBE2T can lead to Fanconi anemia. UBE2T gene gains an alias of FANCT. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Changing College Students’ Stereotypes of Standard English: The Pedagogical Process of an English Course

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James H. Yang

2017-06-01

Full Text Available The use of English as a lingua franca for international communication has made the primacy of Standard English (SE become ideologically undesirable, not only because distinct varieties of English have evolved with their own standards, but also because nonnative speakers tremendously outnumber native speakers and their interaction has soared in intercultural exchange. Accordingly, a curriculum was devised to guide students to explore worldwide English variations in response to the paradigm shift from SE to a pluralistic model of English language teaching. This pedagogical research aims to examine how students transformed their stereotypes of SE into the understanding of world Englishes. This curriculum was implemented in English with 77 undergraduates enrolled in the ‘Language and Culture’ class at a national university in central Taiwan. With the focus on English spoken in New Zealand (NZ, they began with their impressions followed by their revisions. Then, they were guided to discover stories connecting themselves with the country. They proceeded to promote NZ tourism, understand local slang and accent, and take part in an optional semester-final volunteer teaching workshop. Their learning portfolios indicate that they modified their initial stereotypes, generalizations, misconceptions, and prejudices, becoming aware of the cultural diversity in NZ and linguistic differences between NZE and GAE. Overall, 86% of the students found the given instruction helpful for communication with New Zealanders, particularly so among high achievers and those who participated in the teaching service project.

TRAC-PF1/MOD3 calculations of Savannah River Laboratory Rig FA single-annulus heated experiments

International Nuclear Information System (INIS)

Fischer, S.R.; McDaniel, C.K.

1992-01-01

This paper presents the results of TRAC-PF1/MOD3 benchmarks of the Rig FA experiments performed at the Savannah River Laboratory to simulate prototypic reactor fuel assembly behavior over a range of fluid conditions typical of the emergency cooling system (ECS) phase of a loss-of-coolant accident (LOCA). The primary purpose of this work was to use the SRL Rig FA tests to qualify the TRAC-PF1/MOD3 computer code and models for computing Mark-22 fuel assembly LOCA/ECS power limits. This qualification effort was part of a larger effort undertaken by the Los Alamos National Laboratory for the US Department of Energy to independently confirm power limits for the Savannah River Site K Reactor. The results of this benchmark effort as discussed in this paper demonstrate that TRAC/PF1/MOD3 coupled with proper modeling is capable of simulating thermal-hydraulic phenomena typical of that encountered in Mark-22 fuel assembly during LOCA/ECS conditions

Insulin like growth factor-1/insulin bypasses Pref-1/FA1-mediated inhibition of adipocyte differentiation

DEFF Research Database (Denmark)

Zhang, Hongbin; Nøhr, Jane; Jensen, Charlotte Harken

2003-01-01

that forced expression of the soluble form, FA1, or full-length Pref-1 did not inhibit adipocyte differentiation of 3T3-L1 cells when differentiation was induced by standard treatment with methylisobutylxanthine, dexamethasone, and high concentrations of insulin. However, forced expression of either form...... of Pref-1/FA1 in 3T3-L1 or 3T3-F442A cells inhibited adipocyte differentiation when insulin or insulin-like growth factor-1 (IGF-1) was omitted from the differentiation mixture. We demonstrate that the level of the mature form of the IGF-1 receptor is reduced and that IGF-1-dependent activation of p42/p44...... mitogen-activated protein kinases (MAPKs) is compromised in preadipocytes with forced expression of Pref-1. This is accompanied by suppression of clonal expansion and terminal differentiation. Accordingly, supplementation with insulin or IGF-1 rescued p42/p44 MAPK activation, clonal expansion...

The Semantics of Englishes and Creoles

DEFF Research Database (Denmark)

Levisen, Carsten; Priestley, Carol; Nicholls, Sophie

2017-01-01

of these basic meanings across our sample. Secondly, we utilize phylogenetic networks for visualizing our results and as a tool for forming new hypotheses. Our results provide counter-evidence to the claim that Melanesian and Australian creoles are “varieties of English”. In our sample, we find three basic types...... of relations. “Shared-core” types (Australian English v. New Zealand English); “closely related core” types (Hawai’i Creole v. Anglo Englishes); and “distantly related core” types (Tok Pisin v. Anglo English, Kriol v. Anglo English, or Yumplatok v. Anglo English). We measure our results against Scandinavian...

The Home Literacy Environment and the English Narrative Development of Spanish-English Bilingual Children

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Bitetti, Dana; Hammer, Carol Scheffner

2016-01-01

Purpose: The purpose of this study was to examine the impact of the home literacy environment (HLE) on the English narrative development of Spanish-English bilingual children from low-income backgrounds. Method: Longitudinal data were collected on 81 bilingual children from preschool through 1st grade. English narrative skills were assessed in the…

Teaching Intercultural English Learning/Teaching in World Englishes: Some Classroom Activities in South Korea

Science.gov (United States)

Lee, Kang-Young

2012-01-01

This paper discusses what intercultural English learning/teaching (IELT) is in English as a world Englishes (WEes) and how IELT can contribute to the development of proficiency/competence among WEes and can be fitted into actual WEes classrooms. This is to claim that IELT be a pivotal contextual factor facilitating success in…

English Language Schooling, Linguistic Realities, and the Native Speaker of English in Hong Kong

Science.gov (United States)

Hansen Edwards, Jette G.

2018-01-01

The study employs a case study approach to examine the impact of educational backgrounds on nine Hong Kong tertiary students' English and Cantonese language practices and identifications as native speakers of English and Cantonese. The study employed both survey and interview data to probe the participants' English and Cantonese language use at…

An Event-related Brain Potential Study of English Morphosyntactic Processing in Japanese Learners of English

OpenAIRE

Tatsuta, Natsuko

2014-01-01

This dissertation investigated the neural mechanisms underlying English morphosyntactic processing in Case, subject-verb agreement, and past tense inflection in Japanese learners of English (JLEs) using event-related brain potentials (ERPs) in terms of the effects of the age of second language (L2) acquisition (the age of learning English), L2 proficiency level (the English proficiency level), and native/first language (L1) transfer. Researchers have debated for a number of years the question...

An Action Research on Improving Non-English Majors' English Writing by "Basic Sentence Pattern Translation Drills"

Science.gov (United States)

He, Xiaoyu

2016-01-01

English writing plays an indispensible part in EFL (English as a Foreign Language) learning for Chinese students, which accounts for a high score in an English test in China. And it is also a comprehensive reflection of students' abilities in L2 application. However, most non-English majors in vocational and technical colleges have great trouble…

Stress Judgment and Production in English Derivation, and Word Reading in Adult Mandarin-Speaking English Learners.

Science.gov (United States)

Chung, Wei-Lun; Jarmulowicz, Linda

2017-08-01

For monolingual English-speaking children, judgment and production of stress in derived words, including words with phonologically neutral (e.g., -ness) and non-neutral suffixes (e.g., -ity), is important to both academic vocabulary growth and to word reading. For Mandarin-speaking adult English learners (AELs) the challenge of learning the English stress system might be complicated by cross-linguistic differences in prosodic function and features. As Mandarin-speakers become more proficient in English, patterns similar to those seen in monolingual children could emerge in which awareness and use of stress and suffix cues benefit word reading. A correlational design was used to examine the contributions of English stress in derivation with neutral and non-neutral suffixes to English word and nonword reading. Stress judgment in non-neutral derivation predicted word reading after controlling for working memory and English vocabulary; whereas stress production in neutral derivation contributed to word reading and pseudoword decoding, independent of working memory and English vocabulary. Although AELs could use stress and suffix cues for word reading, AELs were different from native English speakers in awareness of non-neutral suffix cues conditioning lexical stress placement. AELs may need to rely on lexical storage of primary stress in derivations with non-neutral suffixes.

Trace elements in diamonds from the Premier, Finsch, and Jagersfontein mines, and their petrogenetic significance

International Nuclear Information System (INIS)

Fesq, H.W.; Bibby, D.M.; Erasmus, C.S.; Kable, E.J.D.

1975-01-01

Neutron-activation studies of the impurity chemistry of more than 1500 natural diamonds from three South African kimberlite sources, Premier, Finsch, and Jagersfontein, provide evidence for the presence of submicroscopic inclusions of a quenched (or temperature re-equilibrated) melt from which these diamonds crystallized. These microscopic inclusions of parental magma contain variable amounts of fluids rich in water and carbon dioxide, as well as iron-nickelcopper-cobalt sulphides, and a major silicate phase, which is remarkably constant in composition irrespective of the source of the diamonds and the age of emplacement of their host kimberlite. These microscopic inclusions are present in varying amounts in all the diamonds that were analysed, and may even dominate the impurity chemistry of diamonds having observable mineral inclusions. An estimate of the composition of the major elements in the silicate melt indicates that the diamonds that were investigated crystallized from picritic magma rich in water and carbon dioxide in the presence of immiscible iron-nickel-copper-cobalt sulphides [af

English-Teaching Institutions in Pakistan.

Science.gov (United States)

Rahman, Tariq

2001-01-01

Discusses English medium teaching in Pakistan and suggests that at the moment it is an elitist preserve and a stumbling block for Pakistanis not taught through English. Indicates that exposing other students to English could counteract growing cultural and religious intolerance in Pakistan. (Author/VWL)

Attitudes of Japanese Learners and Teachers of English towards Non-Standard English in Coursebooks

Science.gov (United States)

Takahashi, Reiko

2017-01-01

Over the decades, efforts have been made to incorporate diverse perspectives on World Englishes into English Language Teaching (ELT) practice and teaching materials. To date, the majority of ELT learners and teachers have not yet been exposed to materials which use and explore non-standard forms of English. This paper examines the attitudes of…

Individual Variables, Attitudes towards English and Being a Teacher: A study on Prospective Teachers of English

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Berna Güryay

2016-05-01

Full Text Available The achievement in learning a foreign language depends not only on cognitive factors such as intelligence, aptitude etc., but also on affective factors such as attitude and motivation. As the main branch of prospective teachers of English is teaching a language, their attitudes towards English and towards being a teacher are of vital importance in their future careers. The purpose of this descriptive study is to determine whether the attitudes of the students of English Language Teaching Department towards English affect their attitudes towards being a teacher of English and whether the students’ attitudes indicate significant differences with regard to individual variables such as gender, class, the types of High Schools from which they have graduated, their socio-economic background, and whether there is a teacher in their family. The sample group of the study were composed 540 prospective English teachers of the first, second, third and fourth year students of the Department of English Language Teaching at Buca Faculty of Education at Dokuz Eylül University, İzmir. For data collection, personal information sheet, the scale for attitudes towards English developed by Altunay (2002 (Alpha Reliability Coefficient: 0.96 and the scale for attitudes towards Being a Teacher developed by Semerci (1999 (Alpha Reliability Coefficient: 0.68 were used. The results indicate that the more positive the students’ attitudes towards English are, the more positive the students’ attitudes towards teaching profession are. Fur thermore, when attitudes towards English and towards being a teacher are compared,” it is indicated that the students’ attitudes towards English are a little bit higher.

Teaching English as an International Language

Science.gov (United States)

Selvi, A. F.; Yazan, B.

2013-01-01

English has unquestionably become a global phenomenon, generating a fundamental discussion of EIL pedagogy for English language teaching practitioners around the world. Teaching English as an International Language captures this important moment in the history of English language teaching. Readers will find an accessible introduction to the past,…

Sequential Introduction of Cations Deriving Large-Grain Csx FA1-x PbI3 Thin Film for Planar Hybrid Solar Cells: Insight into Phase-Segregation and Thermal-Healing Behavior.

Science.gov (United States)

Huang, Jiahao; Xu, Pan; Liu, Jian; You, Xiao-Zeng

2017-03-01

Composition engineering of perovskite materials has been demonstrated to be important for high-performance solar cells. Recently, the energy favorable hybridization of formamidinium (FA) and cesium (Cs) in three dimension lead halide perovskites has been attracting increasing attention due to its potential benefit on durability. Herein, we reported a simple and effective method to produce phase-pure CsxFA1-xPbI3 thin film via sequential introduction of cations, in which the FA cation was introduced by interdiffusion annealing in the presence of N-methylimidazole (NMI). NMI was employed as an additive to slow down the crystallization and thus drive the formation of CsxFA1-xPbI3 with micrometer grain size, which probably facilitate the charge dissociation and transportation in photovoltaic devices. More importantly, composition dependent phase-segregation has been revealed and investigated for the first time during the phase-pure mixed-cation perovskites CsxFA1-xPbI3. The present findings demonstrated that suppressing phase-segregation of mixed-cation perovskites by meticulous composition engineering is significant for further development of efficient photovoltaics. It also suggested that phase-pure Cs0.15FA0.85PbI3 may be a promising candidate with superior phase-durability, which performed an efficiency over 16% in planar perovskite solar cells. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Metabolic engineering of E. coli top 10 for production of vanillin through FA catabolic pathway and bioprocess optimization using RSM.

Science.gov (United States)

Chakraborty, Debkumar; Gupta, Gaganjot; Kaur, Baljinder

2016-12-01

Metabolic engineering and construction of recombinant Escherichia coli strains carrying feruloyl-CoA synthetase and enoyl-CoA hydratase genes for the bioconversion of ferulic acid to vanillin offers an alternative way to produce vanillin. Isolation and designing of fcs and ech genes was carried out using computer assisted protocol and the designed vanillin biosynthetic gene cassette was cloned in pCCIBAC expression vector for introduction in E. coli top 10. Recombinant strain was implemented for the statistical optimization of process parameters influencing F A to vanillin biotransformation. CCD matrix constituted of process variables like FA concentration, time, temperature and biomass with intracellular, extracellular and total vanillin productions as responses. Production was scaled up and 68 mg/L of vanillin was recovered from 10 mg/L of FA using cell extracts from 1 mg biomass within 30 min. Kinetic activity of enzymes were characterized. From LCMS-ESI analysis a metabolic pathway of FA degradation and vanillin production was predicted. Copyright © 2016 Elsevier Inc. All rights reserved.

Dietary fish protein hydrolysates containing bioactive motifs affect serum and adipose tissue fatty acid compositions, serum lipids, postprandial glucose regulation and growth in obese Zucker fa/fa rats.

Science.gov (United States)

Drotningsvik, Aslaug; Mjøs, Svein A; Pampanin, Daniela M; Slizyte, Rasa; Carvajal, Ana; Remman, Tore; Høgøy, Ingmar; Gudbrandsen, Oddrun A

2016-10-01

The world's fisheries and aquaculture industries produce vast amounts of protein-containing by-products that can be enzymatically hydrolysed to smaller peptides and possibly be used as additives to functional foods and nutraceuticals targeted for patients with obesity-related metabolic disorders. To investigate the effects of fish protein hydrolysates on markers of metabolic disorders, obese Zucker fa/fa rats consumed diets with 75 % of protein from casein/whey (CAS) and 25 % from herring (HER) or salmon (SAL) protein hydrolysate from rest raw material, or 100 % protein from CAS for 4 weeks. The fatty acid compositions were similar in the experimental diets, and none of them contained any long-chain n-3 PUFA. Ratios of lysine:arginine and methionine:glycine were lower in HER and SAL diets when compared with CAS, and taurine was detected only in fish protein hydrolysate diets. Motifs with reported hypocholesterolemic or antidiabetic activities were identified in both fish protein hydrolysates. Rats fed HER diet had lower serum HDL-cholesterol and LDL-cholesterol, and higher serum TAG, MUFA and n-3:n-6 PUFA ratio compared with CAS-fed rats. SAL rats gained more weight and had better postprandial glucose regulation compared with CAS rats. Serum lipids and fatty acids were only marginally affected by SAL, but adipose tissue contained less total SFA and more total n-3 PUFA when compared with CAS. To conclude, diets containing hydrolysed rest raw material from herring or salmon proteins may affect growth, lipid metabolism, postprandial glucose regulation and fatty acid composition in serum and adipose tissue in obese Zucker rats.

Hindsight of an English Language Learner.

Science.gov (United States)

Dam, Phap

This keynote address by a native Vietnamese speaker who did not learn English until he was college-age, through the now obsolete "grammar-translation" method, recounts his difficulties in learning to converse orally in English. He stresses the need to teach conversational English to English Language Learners (ELLs) in addition to…

Instrumental Analysis of the English Stops Produced by Arabic Speakers of English

Directory of Open Access Journals (Sweden)

Noureldin Mohamed Abdelaal

2017-07-01

Full Text Available This study reports the findings of a research that was conducted on ten (10 Arab students, who were enrolled in a master of English applied linguistics program at Universiti Putra Malaysia. The research aimed at instrumentally analyzing the English stops produced by Arab learners, in terms of voice onset time (VOT; identifying the effect of their mother tongue on producing the English stops; and the extent Arabic speakers of English differentiate in terms of pronunciation between minimal pairs. The findings of the study showed that some of the subjects’ VOT values were similar to native speakers of English. It was also found that the subjects could differentiate in terms of aspiration or voicing between /p/ and /b/, which refutes the assumption that Arab learners have a problem in producing the /p/ sound with appropriate aspiration. However, they did not show significant difference in pronunciation between the /t/ and /d/ or between the /k/ and /g/. Moreover, there is a kind of limited effect of the L1 on producing some stops (e.g. /t/ and /g/. However, for the /b/ sound, it cannot be inferred that there is interference from the mother tongue because its VOT value is almost the same in English and Arabic. This research suggests that teachers need to enhance Arab learners’ pronunciation of some minimal pairs such as /t/ and /d/ or /k/ and /g/.

Δ{sup 9}-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: Possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells

Energy Technology Data Exchange (ETDEWEB)

Takeda, Shuso [Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511 (Japan); Laboratory of Xenobiotic Metabolism and Environmental Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University (HIU), 5-1-1 Hiro-koshingai, Kure, Hiroshima 737-0112 (Japan); Ikeda, Eriko [Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511 (Japan); Su, Shengzhong [Center for Molecular Toxicology and Carcinogenesis, 101 Life Sciences Building, Pennsylvania State University, University Park, PA 16802 (United States); Harada, Mari [Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511 (Japan); Okazaki, Hiroyuki [Drug Innovation Research Center, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511 (Japan); Yoshioka, Yasushi; Nishimura, Hajime; Ishii, Hiroyuki; Kakizoe, Kazuhiro; Taniguchi, Aya; Tokuyasu, Miki; Himeno, Taichi [Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511 (Japan); Watanabe, Kazuhito [Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181 (Japan); Omiecinski, Curtis J. [Center for Molecular Toxicology and Carcinogenesis, 101 Life Sciences Building, Pennsylvania State University, University Park, PA 16802 (United States); Aramaki, Hironori [Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511 (Japan); Drug Innovation Research Center, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511 (Japan)

2014-12-04

We recently reported that Δ{sup 9}-tetrahydrocannabinol (Δ{sup 9}-THC), a major cannabinoid component in Cannabis Sativa (marijuana), significantly stimulated the expression of fatty acid 2-hydroxylase (FA2H) in human breast cancer MDA-MB-231 cells. Peroxisome proliferator-activated receptor α (PPARα) was previously implicated in this induction. However, the mechanisms mediating this induction have not been elucidated in detail. We performed a DNA microarray analysis of Δ{sup 9}-THC-treated samples and showed the selective up-regulation of the PPARα isoform coupled with the induction of FA2H over the other isoforms (β and γ). Δ{sup 9}-THC itself had no binding/activation potential to/on PPARα, and palmitic acid (PA), a PPARα ligand, exhibited no stimulatory effects on FA2H in MDA-MB-231 cells; thus, we hypothesized that the levels of PPARα induced were involved in the Δ{sup 9}-THC-mediated increase in FA2H. In support of this hypothesis, we herein demonstrated that; (i) Δ{sup 9}-THC activated the basal transcriptional activity of PPARα in a concentration-dependent manner, (ii) the concomitant up-regulation of PPARα/FA2H was caused by Δ{sup 9}-THC, (iii) PA could activate PPARα after the PPARα expression plasmid was introduced, and (iv) the Δ{sup 9}-THC-induced up-regulation of FA2H was further stimulated by the co-treatment with L-663,536 (a known PPARα inducer). Taken together, these results support the concept that the induced levels of PPARα may be involved in the Δ{sup 9}-THC up-regulation of FA2H in MDA-MB-231 cells.

Between Languages and Cultures: Arabic into English Transliteration in English Travel Literature

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Nusaiba Adel Almahameed

2017-09-01

Full Text Available This essay aspires to examine the use of transliteration of some words and phrases from Arabic to English in travel literature books. This has been conducted by exploring the transliterated Arabic words and phrases, and comparing the different transliterations of the same words and phrases by different writers. It investigates the way that the travel writers employ in making plural nouns, the use of the definite article (Al (ال, and Al-tashdid (the duplication of a letter. The conclusion drawn is that travel literature writers resort to transliteration for three reasons; one of the main reasons is that sometimes there is no one-to-one correspondence; the second main reason suggests that transliteration avoids the loss of meaning; and the third one stems from the fact that transliteration helps to find transculturation between cultures. The contributions of this essay would be of concern to scholars, who are interested in Arabic into English transliteration, specifically in English travel literature. According to the researchers’ knowledge, this essay can be considered a leading pioneer study in the field that deals with transliteration from Arabic into English in English travel literature.

The Impact of the Advent of English in Primary Schools on the Development of College English in China

Science.gov (United States)

Liu, Jun; Dai, Zhongxin

2011-01-01

This article discusses the impact of the advent of primary English on the development of College English in China. The advent of English in primary schools as a teaching subject has brought about a downward shift of focus of the English education system in China. Basic English education will be accomplished in primary and secondary schools. The…

Style and Variables in English.

Science.gov (United States)

Shopen, Timothy, Ed.; Williams, Joseph M., Ed.

A collection of articles on the kinds of variation in English that one finds within the language of one group or one person includes: "The English Language as Rule-Governed Behavior" (Timothy Shopen); "The English Language as Use-Governed Behavior" (Joseph M. Williams); "Styles" (Ann D. Zwicky); "The Organization…

Proficiency in English sentence stress production by Cantonese speakers who speak English as a second language (ESL).

Science.gov (United States)

Ng, Manwa L; Chen, Yang

2011-12-01

The present study examined English sentence stress produced by native Cantonese speakers who were speaking English as a second language (ESL). Cantonese ESL speakers' proficiency in English stress production as perceived by English-speaking listeners was also studied. Acoustical parameters associated with sentence stress including fundamental frequency (F0), vowel duration, and intensity were measured from the English sentences produced by 40 Cantonese ESL speakers. Data were compared with those obtained from 40 native speakers of American English. The speech samples were also judged by eight native listeners who were native speakers of American English for placement, degree, and naturalness of stress. Results showed that Cantonese ESL speakers were able to use F0, vowel duration, and intensity to differentiate sentence stress patterns. Yet, both female and male Cantonese ESL speakers exhibited consistently higher F0 in stressed words than English speakers. Overall, Cantonese ESL speakers were found to be proficient in using duration and intensity to signal sentence stress, in a way comparable with English speakers. In addition, F0 and intensity were found to correlate closely with perceptual judgement and the degree of stress with the naturalness of stress.

What Does "Literate in English" Mean?: Divergent Literacy Practices for Vernacular- vs. English-Medium Students in India.

Science.gov (United States)

Ramanathan, Vai

2002-01-01

Offers a close analysis of how English is presented and taught in state-mandated vernacular- and English-medium textbooks used in Grades K-12 in Gujarat, India. Argues that the divergent English instruction as presented in the textbooks contribute to producing two different cultural models regarding being "literate in English."…

English Textbooks in Japan and Korea

Science.gov (United States)

Yuasa, Katsura

2010-01-01

English education in Japan and Korea are similar in some respects. Although both countries are not completely but mostly monolingual societies, where citizens do not need English in their daily life, they have begun to realize the importance of English as a tool for international communication, and as a result their English education is becoming…

English Teaching Profile: Yemen Arab Republic.

Science.gov (United States)

British Council, London (England). English Language and Literature Div.

A description of the role and status of the English language in the Yemen Arab Republic begins with a general statement concerning the distribution of English speakers and the use of English language materials. Subsequent sections outline: (1) the use and status of English within the educational system at all levels, including teacher education;…

The Passive in Singapore English.

Science.gov (United States)

Bao, Zhiming; Wee, Lionel

1999-01-01

Presents an analysis of the two passive (or passive-like) constructions in Singapore English which exhibit substrate influence from Malay and Chinese. The paper shows that while substrate languages contribute to the grammar of Singapore English, the continued prestige of standard English exerts normative pressure and mitigates the effect of…

Modeling a Naturally Ventilated Double Skin Façade with a Building Thermal Simulation Program

DEFF Research Database (Denmark)

Jensen, Rasmus Lund; Kalyanova, Olena; Heiselberg, Per

2008-01-01

to predict. This is manly due to the very transient and complex air flow in the naturally ventilated double skin façade cavity. In this paper the modelling of the DSF using a thermal simulation program, BSim, is discussed. The simulations are based on the measured weather boundary conditions...

English course

CERN Multimedia

HR Department

2011-01-01

General and Professional English Courses The next sessions will take place: From 3rd October 2011 to beginning of February 2012 (break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Kerstin Fuhrmeister, tel. 70896. Oral Expression The next sessions will take place from 3rd October 2011 to beginning of February 2012 (break at Christmas). This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be on average of 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Kerstin Fuhrmeister, tel. 70896. Writing Professional Documents in English - Administrative Wr...

English courses

CERN Multimedia

2013-01-01

Cours d'anglais général et professionnel La prochaine session se déroulera du 4 mars jusqu’au 21 juin 2013. Ces cours s'adressent à toute personne travaillant au CERN ainsi qu'à leur conjoint. Pour le détail des cours proposés, consultez nos pages web. Oral Expression The next sessions will take place from 4 March to 21 June 2013. This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be on average of 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. More information here. Writing Professional Documents in English - Administrative Writing Professional Documents in English - Technical The next sessions will take place from 4 March to 21 June 2013. These courses are designed for people with a goo...

ENGLISH TRAINING

CERN Multimedia

2003-01-01

If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch PLACES AVAILABLE Writing Professional Documents in English This course is designed for people with a good level of spoken English who need to improve their professional writing (administrative, scientific, technical). Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) Date and timetable will be fixed when there are sufficient participants enrolled. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their sp...

Reading Test Performance of English-Language Learners Using an English Dictionary.

Science.gov (United States)

Albus, Debra; Thurlow, Martha; Liu, Kristin; Bielinski, John

2005-01-01

The authors examined the effects of a simplified English dictionary accommodation on the reading-test performance of Hmong English-language learners (ELLs). Participants included a control group of 69 non-ELL students and an experimental group of 133 Hmong ELLs from 3 urban middle schools in Minnesota. In a randomized counterbalanced design, all…

The Religion of Learning English in "English": A Language Educator's Reading

Science.gov (United States)

Gao, Xuesong

2011-01-01

This essay is my reading of "English," a novel based on author Wang Gang's experiences in Urumqi, Xinjiang Uyghur Autonomous Region, Northwest China during the Cultural Revolution (1966-1976). As a language educator, I was particularly interested in the way that Wang describes learning English in the novel. The essay focuses on three…

Influence of the type of lightweight clay brick on the equivalent thermal transmittance of different types of façades on buildings

Directory of Open Access Journals (Sweden)

Morales, M. P.

2016-09-01

Full Text Available This paper compares the equivalent thermal transmittances of different façades built using commercial clay bricks with three different thicknesses and façades made using the same method but with ceramic bricks with optimized rhomboidal interior geometry. Equivalent thermal transmittances of 0.300 W/m2·K were recorded for the rhomboidal brick with a thickness of 0.290 m and a façade with thermo-acoustic insulation and a large format brick on the interior, but the final thickness of the façade was 0.445 m. For ventilated façades made of the proposed rhomboidal brick with thicknesses of 0.290 and 0.240 m an 8–9% improvement was found, with values of 0.312 W/m2·K and 0.339 W/m2·K, respectively. It can be concluded that in view of the small difference in thermal terms, the best option is to use a brick 0.240 m thick, as the overall thickness of the façade will not then exceed 0.300 m.En el presente trabajo se comparan las transmitancias térmicas equivalentes de diferentes fachadas ejecutadas con bloques comerciales de tres espesores 0,290 m, 0,240 m y 0,190 m, con el mismo montaje pero con un bloque cerámico optimizado con geometría interior romboidal. Se ha obtenido una transmitancia térmica equivalente de 0,300 W/m2·K para el ladrillo con geometría romboidal de 0,290 m de espesor y pared con aislamiento termoacústico y gran formato en el interior, con un espesor total de fachada de 0,445 m. Para fachadas ventiladas con el ladrillo romboidal propuesto con espesores de 0,290 y 0,240 m, se obtiene una mejora de un 8%–9%, con valores de 0,312 W/m2·K y 0,339 W/m2·K, respectivamente. Podemos concluir que, dada la pequeña diferencia en términos térmicos, la mejor opción es el uso de ladrillos de 0,240 m de espesor, siempre y cuando el espesor total de fachada no exceda los 0,300 m.

A communicative grammar of English

CERN Document Server

Leech, Geoffrey

2013-01-01

A Communicative Grammar of English has long been established as a grammar innovative in approach, reliable in coverage, and clear in its explanations. This fully revised and redesigned third edition provides up-to-date and accessible help to teachers, advanced learners and undergraduate students of English. Part One looks at the way English grammar varies in different types of English, such as 'formal' and 'informal', 'spoken' and 'written'; Part Two focuses on the uses of grammar rather than on grammatical structure and Part Three provides a handy alphabetically arranged guide to

Associations between Psychosocial Aspects of English Classroom Environments and Motivation Types of Chinese Tertiary-Level English Majors

Science.gov (United States)

Bi, Xuefei

2015-01-01

This study involved whether psychosocial aspects of English classroom environments had associations with the English learning motivation types of Chinese tertiary-level English majors based on a case study of approximate 1,000 English majors in their first 2 years at one of the key universities located in South China. Canonical correlation…

English Sounds and Their Spellings; a Handbook for Teachers and Students. Crowell Contemporary English Series.

Science.gov (United States)

Allen, Robert L.; And Others

This handbook introduces the important correspondences existing between English sounds and English spelling patterns. The lessons present the vowel sounds, one by one, along with systematically selected consonant sounds, and show how each sound or combination of sounds is usually spelled in English words. Irregularly spelled words are introduced…

The Typical Different Features of Grammar of the British English (BrE and American English (AmE

Directory of Open Access Journals (Sweden)

I Wayan Dirgeyasa

2016-08-01

Full Text Available There are a number of varieties of English all over the world such as American, British, Australian, Indian, Singaporean, Philippine English, etc. However, there are only two varieties of English which are most widely and dominantly taught, learned, and used both spoken and printed around the world namely British English (BrE and American English (AmE. In real sense, the two are often confusing for the non-native learners because they have some differences and uniqueness in some aspects such as spelling, pronunciation, vocabulary, and grammar. Therefore, it is really important for students, teachers and speakers as well to be aware of the major differences between the two. This paper is trying to review some striking unique and different features of grammar of British English (BrE and American English (AmE.

English in Myanmar

Science.gov (United States)

Fen, Wong Soon

2005-01-01

This paper provides an overview of the development of English in Myanmar. It begins by tracing the changing role and status of English and Myanmar from the colonial period, which has had an impact on the current education structure. The paper outlines the structure of the education system and the recent reforms that reflect the rising importance…

English Teaching Profile: Sarawak--Malaysia.

Science.gov (United States)

British Council, London (England). English Language and Literature Div.

This review of the status of English language instruction in Sarawak, Malaysia, provides an overview of the role of English in the society in general and outlines the status of English use and instruction in the educational system at all levels (preprimary, elementary, secondary, higher, vocational, adult, and teacher education). Topics covered…

Use of LiDAR for calculating solar irradiance on roofs and façades of buildings at city scale: Methodology, validation, and analysis

Science.gov (United States)

Cheng, Liang; Xu, Hao; Li, Shuyi; Chen, Yanming; Zhang, Fangli; Li, Manchun

2018-04-01

As the rate of urbanization continues to accelerate, the utilization of solar energy in buildings plays an increasingly important role in sustainable urban development. For this purpose, we propose a LiDAR-based joint approach for calculating the solar irradiance incident on roofs and façades of buildings at city scale, which includes a methodology for calculating solar irradiance, the validation of the proposed method, and analysis of its application. The calculation of surface irradiance on buildings may then inform photovoltaic power generation simulations, architectural design, and urban energy planning. Application analyses of the proposed method in the experiment area found that: (1) Global and direct irradiations vary significantly by hour, day, month and season, both following the same trends; however, diffuse irradiance essentially remains unchanged over time. (2) Roof irradiation, but not façade irradiation, displays distinct time-dependent patterns. (3) Global and direct irradiations on roofs are highly correlated with roof aspect and slope, with high global and direct irradiations observed on roofs of aspect 100-250° and slopes of 0-60°, whereas diffuse irradiation on roofs is only affected by roof slope. (4) The façade of a building receives higher levels of global and direct irradiations if facing southeast, south, and southwest; however, diffuse irradiation remains constant regardless of façade orientation.

Life after oral English certification

DEFF Research Database (Denmark)

Dimova, Slobodanka

2017-01-01

, this study discusses the consequences resulting from score and feedback interpretations and uses as part of the validation process of TOEPAS (Test of Oral English Proficiency for Academic Staff), which is a performance-based test used for oral English certification of lecturers at the University......Internationalization of higher education has resulted in rapid developments of English-medium instruction (EMI) courses in non-Anglophone countries in Europe and Asia. Due to the growing concerns about lecturers' ability to teach in English, several European universities have implemented policies...... for internal assessment of lecturers' English proficiency to ensure the quality of teaching in EMI programs. However, research on the measured construct and the reliability and the validity of these assessments remains scarce. Based on interviews with tested university lecturers and formative feedback analysis...

Role of Narrative Skills on Reading Comprehension: Spanish-English and Cantonese-English Dual Language Learners

Science.gov (United States)

Uchikoshi, Yuuko; Yang, Lu; Liu, Siwei

2018-01-01

This longitudinal study examined the role of narrative skills in English reading comprehension, after controlling for vocabulary and decoding, with a sample of 112 dual language learners (DLLs), including both Spanish-English and Cantonese-English children. Decoding, vocabulary, and narrative samples were collected in the winter of first grade and…

AFFECTIVE ASSESSMENT IN ENGLISH LANGUAGE TEACHING

Directory of Open Access Journals (Sweden)

Siti Mariam

2017-04-01

Full Text Available Affective aspect plays important role in man’s life, mainly in making decision, perception, interaction, communication and intelligence. A second behavior domain is the affective domain. The affective domain involves feelings, attitude, interests, preferences, values, and emotions. Emotional stability, motivation, trustworthiness, self-control, and personality are all examples of affective characteristics. Although affective behaviors are rarely assessed formally in schools and classrooms, teachers constantly assess affective behaviors informally, especially when sizing up students. Teachers need to know who can be trusted to work unsupervised and who cannot, who can maintain self-control when the teacher has to leave the classroom and who cannot, who needs to be encouraged to speak in class and who does not, who is interested in science but not in social studies, and who needs to be prodded to start class work and who does not. Most classroom teachers can describe their students’ affective characteristics based on their informal observations and interactions with the students. Statement of the Problem. a Exploration Phase. (1 Can affective aspects improve students’ achievement of English subject for university students of non-English Departments ? (2 Which affective aspects are potentially be used to improve students’ achievement of English subject for university students of non-English Department ? (3 To what extent is the affective assessment of English subject needed by English teachers of non-English Departments ? b Prototype Development Phase. (4 How should the affective assessment model of English subject for university students of non-English Departments be constructed ? (5 How high is the effectiveness of affective assessment model of English subject for university students of non – English Departments ? c Field Assessment Phase. (6 To what extent can the model of affective assessment draft be used to enhance students�

THE ACQUISITION OF ENGLISH SYLLABLE TIMING BY NATIVE SPANISH SPEAKERS LEARNERS OF ENGLISH. AN EMPIRICAL STUDY'

Directory of Open Access Journals (Sweden)

Francisco Gutierrez Diez

2001-06-01

Full Text Available In this article we present part of the results of an empirical research on contrastive rhythm (English-Spanish. Of the several points dealt with in such a research (syllable compression, foot timing, syllable timing and isochrony of rhythmic units, we refer here to syllable duration in English and Spanish as well as the leaming of syllable duration by a group of advanced leamers of English whose first language is Spanish. Regarding the issue of syllable timing, a striking result is the equal duration of unstressed syllables in both languages, which challenges an opposite view underlying a teaching practice common among Spanish teachers of English to Spanish learners of that language. As for the interlanguage of the group of Spanish leamers of English, we comment on the presence of an interference error represented by a stressed/unstressed durational ratio mid way between the ratios for Spanish and English; we have also detected a developmental error related to the tempo employed by the leamers in their syllable timing, which is slower than the tempo produced by native speakers of English.

Unconventional Internships for English Majors.

Science.gov (United States)

Otto, Don H.

After five years of research, the English department at St. Cloud (Minnesota) State University created an internship program for English majors. The philosophy behind the program is that the typical experience of the English major in college is excellent preparation for what the college graduate will be doing in most careers in business,…

Comparison and development of sustainable office façade renovation solutions in the Netherlands

Directory of Open Access Journals (Sweden)

Michiel Ritzen

2013-12-01

Full Text Available Environmental, commercial and societal developments in the Netherlands stimulate the environmental improvement of the existing office building stock. In the Netherlands, about 15% of all office area was vacant in 2012, and the majority of offices have a relative poor energy performance. To measure the improvement, different assessment tools are applied. These tools either focus on one aspect, such as operation energy, and result in a specific outcome such as MJ/m2, or these tools combine different aspects, such as energy and materials, through a weighted system and result in a generic outcome, such as ‘excellent’.In this research, the relation between assessment outcome and actual environmental impact is investigated of both types of tools, by reflecting the outcome of the tool to the carrying capacity of a system. The relation is investigated through a comparison of the energy and material aspect of three office façade renovation solutions using four different assessment tools. Using a tool in which energy and material impact is related to the carrying capacity, current energy focused optimization might lead to a sub optimization of actual environmental impact. To illustrate this, a calculated façade solution is presented with minimal environmental impact based on carrying capacity.

Variable Production of English Past Tense Morphology: A Case Study of a Thai-Speaking Learner of English

Science.gov (United States)

Prapobaratanakul, Chariya; Pongpairoj, Nattama

2016-01-01

The study investigated variable production of English past tense morphology by an L1 Thai-speaking learner of English. Due to the absence of the past tense inflectional morphology in the Thai language, production of English past tense morphemes poses a persistent problem for L1 Thai-speaking learners of English. Hypotheses have been made in…

Performance assessment and development of a design support tool for innovative BIPV façade systems

NARCIS (Netherlands)

Ghasempourabadi, M.

2017-01-01

This PDEng project is related to the development of two types of building-integrated photovoltaic (BIPV) façade systems: SoloWall and ZigZagSolar. SoloWall is a modular type of BIPV for integration in vertical facades, developed by SCX Solar. ZigZagSolar, developed by Wallvision, uses a series of

Computer Multimedia Assisted English Vocabulary Teaching Courseware

Directory of Open Access Journals (Sweden)

Nan Yue

2017-12-01

Full Text Available English vocabulary is often regarded as the most boring link in English learning. However, English vocabulary is the basis of all aspects of English learning. Therefore, enriching the process of English vocabulary learning and stimulating the interest of English vocabulary learning are the keys to the reform of English vocabulary teaching. The computer multimedia is developing and popularizing rapidly with the rapid development of informationization and networking, which plays its role in more and more fields. The application of multimedia technology in the field of teaching is no longer strange. This paper mainly studied the design of computer multimedia assisted English vocabulary teaching courseware. First of all, this paper gave an overview of computer multimedia technology from the aspects of concept, characteristics, development and application situation, which cited and analyzed the cognitive learning theory and memory law. Under the guidance of scientific laws and in combination with the requirement analysis and pattern construction of English vocabulary teaching, this paper realized the module design, style design and database design of English vocabulary courseware. Finally, the content of English vocabulary teaching courseware was demonstrated, and its application effect was verified through the combination of subjective evaluation and objective evaluation. This article has an important guiding significance for stimulating students’ interest in English vocabulary learning and enhancing the quality of vocabulary teaching.

Improve your English the essential guide to English grammar, punctuation and spelling

CERN Document Server

Astle, JE Metcalfe & C

2013-01-01

It's important in our daily lives for us to write clear English which is easily understood. If we get the basics wrong, our words may be misinterpreted and cause confusion. To make sure our written words convey our exact meanings, we need to understand the fundamentals of the English language, such as the parts of speech, how sentences and paragraphs are constructed, and the correct use of punctuation. We also need to spell the words correctly!This indispensable reference guide to the rules and conventions governing written English will help all those who are unsure about whether to use ""i

Symposium: What Is College English?

Science.gov (United States)

Bloom, Lynn Z.; White, Edward M.; Enoch, Jessica; Hawk, Byron

2013-01-01

This symposium explores the role(s) College English has (or has not) had in the scholarly work of four scholars. Lynn Bloom explores the many ways College English influenced her work and the work of others throughout their scholarly lives. Edward M. White examines four articles he has published in College English and draws connections between…

Meaning and the English verb

CERN Document Server

Leech, Geoffrey

2014-01-01

Every language has its peculiar problems of meaning for the foreign learner. In the English language, some of the biggest yet most fascinating problems are concentrated in the area of the finite verb phrase: in particular, tense, aspect, mood and modality. Meaning and the English Verb describes these fields in detail for teachers and advanced students of English as a foreign or second language. This new third edition uses up-to-date examples to show differences and similarities between American and British english, reflecting a great deal of recent research in this area. It also takes account

A Comparison of Motivation to Learn English between English Major and Non-English Major Students in a Vietnamese University

Science.gov (United States)

Ngo, Huong; Spooner-Lane, Rebecca; Mergler, Amanda

2017-01-01

Despite the plethora of literature examining higher education students' motivation to learn a second language, it is not known if students who choose to study English as their major differ from those who are required to study English as the minor component of their wider degree. Drawing on self-determination theory, this paper reports on the…

Exposure to Multiple Accents of English in the English Language Teaching Classroom: From Second Language Learners' Perspectives

Science.gov (United States)

Sung, Chit Cheung Matthew

2016-01-01

As a result of the global presence of English as a Lingua Franca (ELF), it has been argued that learners of English should be exposed to a range of varieties of English, rather than a single variety of English, so that they can be better prepared to communicate with other people in ELF communication. However, little is known about second language…

Webster's word power better English grammar improve your written and spoken English

CERN Document Server

Kirkpatrick, Betty

2014-01-01

With questions and answer sections throughout, this book helps you to improve your written and spoken English through understanding the structure of the English language. This is a thorough and useful book with all parts of speech and grammar explained. Used by ELT self-study students.

Nordic Journal of English Studies

DEFF Research Database (Denmark)

2008-01-01

In difficult economic times, the place of education in the economy comes to the forefront with questions about how effective our programs are in preparing students to become contributing members of the workforce and society. As the discipline of English studies sits at the cross-roads of humanities...... and education for a global society, it has traditionally enjoyed high enrollments and unquestioned value. However, two trends are affecting the position of English studies in the academy: 1) the emergence of communication studies as a discipline and 2) the movement towards education in English as a global...... language across many disciplines in Scandinavia. Because of these movements, the place and purpose for English studies is being called into question. In addition, the ability of an English studies degree in preparing students for the global workforce is also being examined. To address these emergent trends...

On English Locative Subjects

Directory of Open Access Journals (Sweden)

Gabriela Brůhová

2017-07-01

Full Text Available The paper analyses English sentences with thematic locative subjects. These subjects were detected as translation counterparts of Czech sentenceinitial locative adverbials realized by prepositional phrases with the prepositions do (into, na (on, v/ve (in, z/ze (from complemented by a noun. In the corresponding English structure, the initial scene-setting adverbial is reflected in the thematic subject, which results in the locative semantics of the subject. The sentences are analysed from syntactic, semantic and FSP aspects. From the syntactic point of view, we found five syntactic patterns of the English sentences with a locative subject (SV, SVA, SVO, SVpassA and SVCs that correspond to Czech sentences with initial locative adverbials. On the FSP level the paper studies the potential of the sentences to implement the Presentation or Quality Scale. Since it is the “semantic content of the verb that actuates the presentation semantics of the sentence” (Duškova, 2015a: 260, major attention is paid to the syntactic-semantic structure of the verb. The analysis of the semantics of the English sentences results in the identification of two semantic classes of verbs which co-occur with the English locative subject.

NEGATION AFFIXES IN ENGLISH

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Dedy Subandowo -

2017-02-01

Full Text Available Abstract: This research entitled "Negation Affixes in English". This study is aimed to describe the various negation affixes in English, morphological process, morphophonemic and meaning. The research data were taken from various sources of English grammar book, morphology, research journal and the book which relatees to the research. English grammar books used in this study are written by Otto Jesperson, Marcella Frank, Greenbaum and Geoffrey Leech.  The method used in this research is the descriptive-qualitative method. While the data collection techniques are performed by using jot-down method. And the results of analysis are presented in tabular form and descriptive method. The result of the research shows that English has six types of negative affixes which are categorized by the intensity of its appearance, such as dis-, in-, non-, un-, anti- and -less. Based on the function, negation affixes are divided into several categories such as adjectives, nouns, verbs, and adverbs. The morphophonemic affix in- has four allomorphs, they are in-, im-, il- and ir- . While the analysis revealed that negation affixes have some basic meanings, such as ‘not’, ‘without’, and ‘anti’.

Cytotoxicity of the dicarboximide fungicides, vinclozolin and iprodione, in rat hepatoma-derived Fa32 cells.

Science.gov (United States)

Dierickx, Paul J

2004-10-01

Dicarboximide fungicides are widely used to control various fungal species. Their primary action is not known, due to a lack of knowledge concerning the mechanism of action of the dicarboximide group. The cytotoxicities of vinclozolin and iprodione in rat hepatoma-derived Fa32 cells were investigated. Cytotoxicity was measured by neutral red uptake inhibition after treatment for 24 hours. Iprodione was more toxic than vinclozolin. Vinclozolin was less toxic in glutathione-depleted cells than in control cells. This was also true for iprodione at lower concentrations, but iprodione became more toxic at higher concentrations. Both the fungicides increased the endogenous glutathione content by 20% after 1 hour. After 24 hours, the glutathione content was doubled by vinclozolin, but was not affected by iprodione. No effect on glutathione S-transferase activity or reactive oxygen species formation could be observed. Cytochrome P450-dependent ethoxyresorufin-O-deethylase and pentoxyresorufin-O-depentylase activities were moderately activated by iprodione and strongly activated by vinclozolin. A glutathione-related cytochrome P450-dependent metabolic attack of vinclozolin and iprodione could be responsible for their cytotoxicity in Fa32 cells. Further research is needed to fully elucidate these (or other) mechanisms.

The English as a Foreign Language / Lingua Franca Debate: Sensitising Teachers of English as a Foreign Language Towards Teaching English as a Lingua Franca

Directory of Open Access Journals (Sweden)