WorldWideScience

Sample records for english fa premier

  1. High-intensity running in English FA Premier League soccer matches

    DEFF Research Database (Denmark)

    Bradley, Paul S.; Sheldon, William; Wooster, Blake

    2009-01-01

    The aims of this study were to (1) determine the activity profiles of a large sample of English FA Premier League soccer players and (2) examine high-intensity running during elite-standard soccer matches for players in various playing positions. Twenty-eight English FA Premier League games were...... with and without ball possession is reduced during various phases of elite-standard soccer matches and the activity profiles and fatigue patterns vary among playing positions. The current findings provide valuable information about the high-intensity running patterns of a large sample of elite-standard soccer...

  2. The effect of playing formation on high-intensity running and technical profiles in English FA Premier League soccer matches

    DEFF Research Database (Denmark)

    Bradley, Paul S; Carling, Chris; Archer, Dave

    2011-01-01

    The aim of this study was to examine the effect of playing formation on high-intensity running and technical performance during elite soccer matches. Twenty English FA Premier League games were analysed using a multiple-camera computerized tracking system (n = 153 players). Overall ball possession...

  3. FA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — An Area Forecast (FA) is a forecast of Visual Flight Rules (VFR) clouds and weather conditions over an area as large as the size of several states.

  4. THE CORRELATION BETWEEN PLAYER VALUATION AND THE BARGAINING POSITION OF CLUBS IN THE ENGLISH PREMIER LEAGUE (EPL)

    OpenAIRE

    Swanepoel, M.J.; Swanepoel, J.

    2016-01-01

    Soccer is perhaps the most loved game in the world, filled with passion both on and off the field. Literature suggests that the English Premier League (EPL) is one of the most sought after championship in soccer. The study investigates the relationship between player valuation and the bargaining positions of clubs in the English Premier League (EPL). A comprehensive literature analysis illustrates that the bargaining positions of clubs should consider factors such as previous seasons’ f...

  5. Football fans and food: a case study of a football club in the English premier league.

    Science.gov (United States)

    Ireland, Robin; Watkins, Francine

    2010-05-01

    Although there is growing awareness of the impact of diet on health, little attention has been given to the food available in our sports stadia. We used a football club (Citygrene FC) - Citygrene is a fictional name - in the English Premier League as a case study to examine the attitudes of male and female football supporters to the food and drink available at their home stadium (Citygrene Stadium). The research design used five focus groups of male and female fans. The discourse was audiotaped, transcribed, coded and analysed for themes. A football stadium in the English Premier League, England. The participants were season ticket holders drawn from two stands at Citygrene Stadium. The research showed a high level of dissatisfaction with the food and drink supplied. There were key differences in the views of the male and female participants in the focus groups, with the women more concerned about wider issues such as the lack of healthy food. Both men and women were aware of their role as consumers and felt that there was an opportunity for Citygrene to improve their catering profits, if they provided a better selection of food and drink and an improved service. The study shows that there is a demand for healthier food options (and a wider choice of food and drink in general), which may provide an economic opportunity for stadium and catering managers. In addition, a stadium may be considered a potential 'healthy setting', which can serve as a supportive environment for healthier food choices.

  6. Predicting Football Matches Results using Bayesian Networks for English Premier League (EPL)

    Science.gov (United States)

    Razali, Nazim; Mustapha, Aida; Yatim, Faiz Ahmad; Aziz, Ruhaya Ab

    2017-08-01

    The issues of modeling asscoiation football prediction model has become increasingly popular in the last few years and many different approaches of prediction models have been proposed with the point of evaluating the attributes that lead a football team to lose, draw or win the match. There are three types of approaches has been considered for predicting football matches results which include statistical approaches, machine learning approaches and Bayesian approaches. Lately, many studies regarding football prediction models has been produced using Bayesian approaches. This paper proposes a Bayesian Networks (BNs) to predict the results of football matches in term of home win (H), away win (A) and draw (D). The English Premier League (EPL) for three seasons of 2010-2011, 2011-2012 and 2012-2013 has been selected and reviewed. K-fold cross validation has been used for testing the accuracy of prediction model. The required information about the football data is sourced from a legitimate site at http://www.football-data.co.uk. BNs achieved predictive accuracy of 75.09% in average across three seasons. It is hoped that the results could be used as the benchmark output for future research in predicting football matches results.

  7. Shirt sponsorship by gambling companies in the English and Scottish Premier Leagues: global reach and public health concerns

    OpenAIRE

    Bunn, C.; Ireland, R.; Minton, J.; Holman, D.J.; Philpott, M.; Chambers, S.

    2018-01-01

    While the nature of gambling practices is contested, a strong evidence\\ud base demonstrates that gambling can become a serious disorder and have\\ud a range of detrimental effects for individuals, communities and societies.\\ud Over the last decade, football in the UK has become visibly entwined with\\ud gambling marketing. To explore this apparent trend, we tracked shirt\\ud sponsors in both the English and Scottish Premier Leagues since 1992 and\\ud found a pronounced increase in the presence of...

  8. The effect of match standard and referee experience on the objective and subjective match workload of English Premier League referees.

    Science.gov (United States)

    Weston, M; Bird, S; Helsen, W; Nevill, A; Castagna, C

    2006-06-01

    The aim of the present study was to examine the effect of match standard and referee experience on the objective and subjective workload of referees during English Premier League and Football League soccer matches. We also examined the relationship between heart rate (HR) and ratings of perceived exertion (RPE) for assessing match intensity in soccer referees. Heart rate responses were recorded using short-range telemetry and RPE scores were collected using a 10-point scale. Analysis revealed a significant relationship between mean match HR and match RPE scores (r=0.485, pFootball League 81.5+/-2.2%HRmax, pFootball League 6.9+/-0.8, pReferee experience had no effect on match HR and RPE responses to Premier League and Football League matches. The results of the present study demonstrate the validity of using HR and RPE as a measure of global match intensity in soccer referees. Referee experience had no effect on the referees' objective and subjective match workload assessments, whereas match intensity was correlated to competition standard. These findings have implications for fitness preparation and evaluation in soccer referees. When progressing to a higher level of competition, referees should ensure that appropriate levels of fitness are developed in order to enable them to cope with an increase in physical match demands.

  9. An examination of the migratory transition of elite young European soccer players to the English Premier League.

    Science.gov (United States)

    Richardson, David; Littlewood, Martin; Nesti, Mark; Benstead, Luke

    2012-01-01

    The migration of soccer players has increased in recent years. In this study, we examined the experiences of elite young soccer players as they engaged in a migratory transition from their home country to an English Premier League (EPL) club. Five young players, who made the migratory transition between the ages of 16 and 24, were interviewed. Data were analysed using the principles of content analysis. Verbatim text was then aligned to the emergent themes. Results indicate that young migratory players face the initial frenzy that is associated with an approach from an EPL club before going through a "decision" phase, followed by a period of "migration" and "acculturation" before establishing (or not) their "home from home". The challenges of leaving home and family while trying to establish themselves as a professional player in an environment that (still) appears to be beset with (traditional) English soccer culture (i.e. high tempo, ruthless, macho, and aggressive) are recounted. While the player's family was a significant source of social support, there is still a need for qualified personnel (e.g. sports psychologists) and/or appropriately trained international recruitment staff and football agents (i.e. in areas of social, psychological, and/or performance lifestyle) to support young players through their migratory transition.

  10. Analysis of physical match performance in English Premier League soccer referees with particular reference to first half and player work rates.

    Science.gov (United States)

    Weston, Matthew; Castagna, Carlo; Impellizzeri, Franco M; Rampinini, Ermanno; Abt, Grant

    2007-12-01

    The aim of the present study was to examine the influence of first half activity, overall match intensity and seasonal variation on the physical match performances of English Premier League football referees. Match analysis data was collected using the Prozone match analysis system from 19 full-time professional referees during a total of 254 matches in the 2004-2005 season. Physical match performances were classified into three separate categories: 1, total distance covered (TD); 2, high-intensity running distance (running speed>5.5m/s, HIR); 3, average distance from infringements (DI). Using these match activity variables the influence of first half TD and HIR distances on second half activities and also the influence of players' match activities upon the referees' physical match performances were examined. The main finding of the present study was that the physical match performances of the referees were partly related to those of the players, in that the referees' HIR correlated with players' HIR (r=0.43, preferees (r=0.47 and r=0.52, respectively, preferee. Further examination is required as to whether reduced physical performances in the second half of matches are a consequence of referee fatigue, tactical strategies on behalf of the referee or reduced player match activities resulting in a slower tempo of match.

  11. Premier Hospital Historical Data

    Data.gov (United States)

    U.S. Department of Health & Human Services — To provide a historical overview of the participating hospitals, before the first project report, Premier Healthcare Informatics has used data already available for...

  12. Translation into english of excerpts from Faïza Guène's "du rêve pour les oufs"

    OpenAIRE

    Chatelain, Kristin

    2010-01-01

    An annotated translation of selections from Faïza Guène's "Du rêve pour les oufs", touching on the points of skopos, target audience, explicitation and substitution, domestication and foreignization, and functional adequacy.

  13. Some examples of external colouration on English brick buildings, c. 1500-1650 Étude de façades peintes de palais anglais, entre 1500 et 1650

    Directory of Open Access Journals (Sweden)

    Jonathan Foyle

    2008-06-01

    Full Text Available De études récentes réalisées sur les palais de Hampton Court et Kew Palace ont révélé l’histoire de la couleur des façades. Deux approches successives ont pu être définies. Au xvie siècle, on choisit de simuler une façade de brique par l’emploi de peintures rouge, blanche et noire. Cet usage met en avant la brique dans toute sa dimension décorative. Au xviie siècle, on s’intéresse plutôt à l’usage d’un enduit ocre rouge uniforme appelé « ruddle ». Cette pratique efface la présence de la brique et accentue l’impression d’homogénéité et de « monolithisme » des bâtiments. Cette intervention examine les origines possibles de ces traditions et expose les conséquences du rétablissement de la technique du « ruddling » à Kew Palace.The application of coloured limewashes as external surface finishes on many historic English buildings largely determined the original appearance and intended effect of their architecture. As the final stage in the process of construction, limewashes were more than the thin cosmetics which created the skin‑deep beauty of the building; they could articulate and emphasize chosen architectural elements, or conversely suppress the busy individual units of mural masonry in favour of revealing the entire building in a monolithic homogeneity of colour and texture. This paper examines some English brick buildings of c. 1500‑1650 with which the author is familiar, and asks of the surviving evidence to what extent, how and why colour was applied.

  14. Premier's imaging IR limb sounder

    Science.gov (United States)

    Kraft, Stefan; Bézy, Jean-Loup; Meynart, Roland; Langen, Jörg; Carnicero Dominguez, Bernardo; Bensi, Paolo; Silvestrin, Pierluigi

    2017-11-01

    The Imaging IR Limb Sounder (IRLS) is one of the two instruments planned on board of the candidate Earth Explorer Core Mission PREMIER. PREMIER stands for PRocess Exploration through Measurements of Infrared and Millimetre-wave Emitted Radiation. PREMIER went recently through the process of a feasibility study (Phase A) within the Earth Observation Envelope Program. Emerging from recent advanced instrument technologies IRLS shall, next to a millimetre-wave limb sounder (called STEAMR), explore the benefits of three-dimensional limb sounding with embedded cloud imaging capability. Such 3D imaging technology is expected to open a new era of limb sounding that will allow detailed studies of the link between atmospheric composition and climate, since it will map simultaneously fields of temperature and many trace gases in the mid/upper troposphere and stratosphere across a large vertical and horizontal field of view and with high vertical and horizontal resolution. PREMIER shall fly in a tandem formation looking backwards to METOP's swath and thereby improve meteorological and environmental analyses.

  15. ming-fa hsieh

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. MING-FA HSIEH. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1179-1187. Preparation, characterization of chitosan/bamboo charcoal/poly(methacrylate) composite beads · DOROTHY CAMINOS-PERUELO WEI-CHIEH WANG ...

  16. English

    African Journals Online (AJOL)

    Owner

    To a dubious critical salvation: Etienne Leroux and the canons of South African English criticism. This article presents a case study in cross-cultural literary reception following the act of literary translation—in this instance, of author Etienne Leroux—from Afrikaans into English. It describes the literary reception of Leroux in ...

  17. English

    DEFF Research Database (Denmark)

    Phillipson, Robert

    2011-01-01

    The article exemplifies and presents the characteristics of linguistic imperialism, linguistic capital accumulation following the same pattern as capitalist economic dominance. The text summarizes the way English was established in the colonial period. Many of the mechanisms of linguistic hierarc...... of the English iceberg....

  18. English

    DEFF Research Database (Denmark)

    Phillipson, Robert

    2011-01-01

    The article exemplifies and presents the characteristics of linguistic imperialism, linguistic capital accumulation following the same pattern as capitalist economic dominance. The text summarizes the way English was established in the colonial period. Many of the mechanisms of linguistic hierarchy...... to the present-day world ‘order’, as the postcolonial is subsumed under global empire, assisted by English linguistic neoimperialism. Some scholars who deny the existence of linguistic imperialism are reported on, and the complexity of language policy in European integration is demonstrated. The article...

  19. Mastering Adobe Premiere Pro CS6

    CERN Document Server

    Ekert, Paul

    2013-01-01

    Designed to be practical and engaging, Mastering Adobe Premiere Pro CS6 is a project-based book to help you truly augment your skills and become a film editing hotshot.If you're just starting out or even migrating from existing video editing software, then this book is for you. With rapid progression through practical examples constructed to be both engaging and useful, Mastering Adobe Premiere Pro CS6 is ideal for learning the sometimes complex workflows of this powerful application.

  20. Video Analysis of Musculoskeletal Injuries in Nigerian and English ...

    African Journals Online (AJOL)

    Video Analysis of Musculoskeletal Injuries in Nigerian and English Professional Soccer Leagues: A Comparative Study. ... The knee and the ankle were the most common injured parts. Most injuries were caused by tackling ... Keywords: Soccer Players, Nigerian Premier League, English Premier League. Musculoskeletal ...

  1. Premier Wen hails sci-tech cooperation with CERN

    CERN Multimedia

    2004-01-01

    Premier Wen Jiabao met CERN's director general Dr Robert Aymar and physicist and Nobel laureate Dr Samuel Chao Chung Ting. Premier Wen emphasied the importance for China to collaborate on fundamental science (0.5 page)

  2. What’s a Cricketer’s Worth? Predicting Bid Prices for Indian Premier League Auctions

    OpenAIRE

    Siddhartha K. RASTOGI

    2017-01-01

    Indian Premier League is a twenty-over format cricket tournament of teams representing different Indian cities. Beginning 2008, it is established now as a grand annual affair. The team franchises are auctioned on long term basis, whereas cricketers are auctioned every season under certain conditions. Despite such wealth of information, studies on IPL auctions are rare barring four cited models. The present paper studies the results of year 2011 English-style auction of cricketers and recalibr...

  3. Le Premier Amendement : un mythe

    Directory of Open Access Journals (Sweden)

    Claude‑Jean Bertrand

    2006-03-01

    Full Text Available Ce papier, plein de verve, d’humeur et d’humour, pose, comme sait si bien le faire l’auteur, des questions profondes sous une apparence paradoxale. Il a été présenté lors d’un colloque sur le Premier amendement organisé à l’Université Lumière-Lyon 2 les 17 et 18 janvier 2003. Certaines communications ont été publiées dans le volume XXIV, n°1 (2003, « Le premier amendement : un modèle américain des libertés » (sous la direction de Vincent Michelot de la Revue Tocqueville.

  4. Differential responsiveness of obese (fa/fa) and lean (Fa/Fa) Zucker rats to cytokine-induced anorexia.

    Science.gov (United States)

    Plata-Salamán, C R; Vasselli, J R; Sonti, G

    1997-01-01

    Pathophysiological and pharmacological concentrations of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) in the cerebrospinal fluid (CSF) induce anorexia in normal rats. Obesity in humans and rodents is associated with increased TNF-alpha messenger RNA and protein levels in various cell types. This suggests that obese individuals may have differential regulation of cytokine production and dissimilar responsiveness to cytokines. In the present study, we investigated the effects of the intracerebroventricular (ICV) microinfusion of TNF-alpha (50, 100, and 500 ng/rat), IL-1 beta (1.0, 4.0, and 8.0 ng), and TNF-alpha (100 ng) plus IL-1 beta (1.0 ng) on obese (fa/fa) and lean (Fa/Fa) Zucker rats. The results show that: TNF-alpha and IL-1 beta, and the concomitant administration of TNF-alpha and IL-1 beta decreased the short-term (4 hours), nighttime (12 hours), and total daily food intakes in obese and lean rats; IL-1 beta was more potent relative to TNF-alpha; obese rats showed greater responsiveness to IL-1 beta: 8.0 ng IL-1 beta, for example, decreased the 12-hour food intake by 52% in obese and 22% in lean rats. On the other hand, obese and lean rats did not exhibit a significantly different responsiveness to the anorexia induced by 50, 100, or 500 ng TNF-alpha at the 4-hour period; and the concomitant ICV administration of TNF-alpha and IL-1 beta induced anorexia with additive (4-hour period) or synergistic (12-hour and 24-hour periods) effects in obese rats. The effect of TNF-alpha plus IL-1 beta in lean rats was greater than additive for the 12-hour and 24-hour periods. The difference in suppression of total daily food intake by TNF-alpha plus IL-1 beta in obese (-43%) versus lean (-23%) rats was significantly different (p < 0.01). The results show that obese (fa/fa) and lean (Fa/Fa) Zucker rats have differential responsiveness to the ICV microinfusion of two different classes of cytokines.

  5. FA

    African Journals Online (AJOL)

    spamer

    The most important pelagic fisheries are located in the upwelling areas of eastern boundary currents, i.e. the Canary, the. Benguela, the California and the Humboldt Current systems. Two fisheries contribute most to the world pelagic fish catch: the Peruvian and the Chilean fisheries. Annually, the landings off Peru and Chile.

  6. Management and marketing of sporting events: Nike Premier Cup Project

    OpenAIRE

    Nedbal, Jakub

    2008-01-01

    Title: Management and marketing ofsporting events: Nike Premier Cup project Points of thesis: Publish the Nike Premier Cup promotion campaign project and point out improvement possibilities for upcoming years based on analysis ofpast and present state. Methods: Data will be obtained by interview, observation, description analysis and SWOT analysis Results: Promotion campaign, improvement possibilities, final day schedule Keywords: SWOT analysis, promotion, management, marketing, Nike Premier ...

  7. Echographie devant une metrorragie du premier trimestre de ...

    African Journals Online (AJOL)

    Echographie devant une metrorragie du premier trimestre de grossesse sur uterus bicorne a issue favorable. Vaginal bleeding in a pregnant woman with a bicornuate uterus, ultrasound finding and favourable outcome.

  8. Engagement: The Nations Premier Grand Strategy, Who's In Charge?

    National Research Council Canada - National Science Library

    Derrick, Robert

    1998-01-01

    Selective Engagement, one of the premiere post cold war grand strategies, refers to activities between the US and other nations ranging from trade relations to diplomatic recognition to combined military exercises...

  9. Echographie devant une metrorragie du premier trimestre de ...

    African Journals Online (AJOL)

    Nous rapportons un cas de grossesse dans un utérus bicorne, avec un épisode de saignement vaginal durant le premier trimestre. L'échographie a été capable de trouver un épaississement de l'endomètre de la corne utérine vide qui pourrait expliquer cette métrorragie. Mots clés : Utérus bicorne, métrorragie, premier ...

  10. The Arabic Hyperbolic Pattern "Fa??al" in Two Recent Translations of the Qur'an

    Science.gov (United States)

    El-Zawawy, Amr M.

    2014-01-01

    The present study addresses the problem of rendering the ?? ?? 'fa??al' hyperbolic pattern into English in two recent translations of the Qur'an. Due to the variety of Qur'an translations and the large amount of hyperbolic forms of Arabic verbs recorded in the Qur'an, only two translations of the Qur'an are consulted and analyzed: these two…

  11. TRIM.FaTE Evaluation Report

    Science.gov (United States)

    The TRIM.FaTE Evaluation Report is composed of three volumes. Volume I presents conceptual, mechanistic, and structural complexity evaluations of various aspects of the model. Volumes II and III present performance evaluation.

  12. The Role of Internet in Marketing Premiering Movies

    OpenAIRE

    Tuohimaa, Suvi

    2010-01-01

    The objective of this thesis was to find out about the role of Internet today in premiering movie marketing and whether Internet is a good tool for it. The hope was to obtain new information provided by moviegoers and to contribute something useful to the art of marketing premiering movies. This thesis was a part of the School of Business and Information Management's Innomajakka-project but did not have an official commissioner, so the topic for the thesis came from the writer's personal and ...

  13. What’s a Cricketer’s Worth? Predicting Bid Prices for Indian Premier League Auctions

    Directory of Open Access Journals (Sweden)

    Siddhartha K. RASTOGI

    2017-04-01

    Full Text Available Indian Premier League is a twenty-over format cricket tournament of teams representing different Indian cities. Beginning 2008, it is established now as a grand annual affair. The team franchises are auctioned on long term basis, whereas cricketers are auctioned every season under certain conditions. Despite such wealth of information, studies on IPL auctions are rare barring four cited models. The present paper studies the results of year 2011 English-style auction of cricketers and recalibrates the old yet most accurate model by Rastogi and Deodhar (2009. Both models use ordinary least square method of regression albeit with different variable. The old models lack predictive power, whereas the recalibrated model presented displays better predictive capability as compared to earlier models. It also succeeds in reducing overall predictability gap and stands significantly parsimonious vis-à-vis previous models. Further, the final model presented is applied on 2013 and 2014 auction data to show superior results.

  14. Physiological response of one of South Africa's premier freshwater ...

    African Journals Online (AJOL)

    Physiological response of one of South Africa's premier freshwater sport angling species, the Orange-Vaal smallmouth yellowfish Labeobarbus aeneus, ... These data suggest that catch-and-release causes physiological stress to fish, but nonetheless this practice can be a valuable fisheries management tool to ensure the ...

  15. Open Access Publishing in Indian Premier Research Institutions

    Science.gov (United States)

    Bhat, Mohammad Hanief

    2009-01-01

    Introduction: Publishing research findings in open access journals is a means of enhancing visibility and consequently increasing the impact of publications. This study provides an overview of open access publishing in premier research institutes of India. Method: The publication output of each institution from 2003 to 2007 was ascertained through…

  16. Trichoberoard gastrique : Premier cas observe en milieu bur kina be ...

    African Journals Online (AJOL)

    Le trichobezoard est une concretion de cheveux, de poils ou de fibres de tapis et de debris alimentaire, localisee habituellement dans l'estomac. Le trichobezoard est une pathologie rare qui survient habituellement chez des adolescentes presentant des troubles psychiques. La premiere observation de trichobezoard a ete ...

  17. Premiere toob lavale jalgpallimeeskonna, inimkatsed ja punase tooli / Kairi Prints

    Index Scriptorium Estoniae

    Prints, Kairi, 1977-

    2012-01-01

    Premiere 2012 osalevad neli Eesti tantsukunstnikku: Svetlana Grigorjeva tantsulavastusega "sõp rus est", Kaisa Selde, Kristina-Maria Heinsalu ja Christin Lunts tantsulavastusega "fie", esmakordselt võtab osa välismaalane - sakslanna Mareike Franz tantsulavastusega "Duett". Kõik esietenduvad 9. veebruaril Kanuti gildi saalis

  18. Premier League Reading STARS 2013/14. Evaluation Report

    Science.gov (United States)

    Pabion, Clémence

    2015-01-01

    The National Literacy Trust's Premier League Reading Stars programme (PLRS) is a reading intervention for children aged 8 to 13 that captures the motivational power of football to inspire children and young people to read more and to improve their literacy skills. PLRS is delivered by teachers and librarians. The programme delivers statutory…

  19. International Façades - CROFT : Climate Related Optimized Façade Technologies

    NARCIS (Netherlands)

    Bilow, M.

    2012-01-01

    "International Façades - CROFT" links the fields of architecture, building services and building physics. It aims at an international diversity in façade design to reduce energy consumption in building design. Current architectural planning practices, such as the International Style, perceive the

  20. Designing Urban Media Façades

    DEFF Research Database (Denmark)

    Dalsgaard, Peter; Halskov, Kim

    2010-01-01

    of issues: interfaces, physical integration, robustness, content, stakeholders, situation, social relations, and emerging use. The challenges reflect the fact that the urban setting as a domain for interaction design is characterized by a number of circumstances and socio-cultural practices that differ from......Media façades comprise a category of urban computing concerned with the integration of displays into the built environment, including buildings and street furniture. This paper identifies and discusses eight challenges faced when designing urban media façades. The challenges concern a broad range...

  1. The impact of dermatology in premier medicine journals.

    Science.gov (United States)

    Kheterpal, Meenal K; Ellis, Charles N

    2011-01-01

    In the past 15 years, research in dermatology has significantly increased. Dermatology-related contributions in premier medical journals such as The New England Journal of Medicine (NEJM) and The Journal of the American Medical Association (JAMA) are the representation of our field in the medical world. To analyze this representation, incidence of dermatology-related contributions in NEJM and JAMA during 3 separate years (during a 15-year period) was calculated.

  2. Market Segmentation, Targeting, Dan Brand Positioning Dari Winston Premier Surabaya

    OpenAIRE

    Tania, Debby

    2014-01-01

    Sejak tahun 2012 mulai terasa bahwa bisnis properti mengalami kenaikan di Indonesia. Banyak masyarakat Indonesia berinvestasi pada properti karena dianggap aman dan menguntungkan. Sehingga muncul banyak produk properti baru di Indonesia. Perkembangan properti di Indonesia menjadi peluang besar bagi Agen Properti untuk dapat menjalankan bisnisnya. Winston Premier sebagai salah satu Agen properti di Surabaya Barat yang baru berdiri memerlukan strategi pemasaran yang tepat untuk digunakan guna b...

  3. Indian premier league- The value of a player

    OpenAIRE

    Denduluri, Arun

    2017-01-01

    The paper tries to examine and tries to estimate the importance of various characteristics based on the real international statistics of the game of cricket that go into defining and explaining specific monetary values for the cricketers. The auction process employed in the Indian premier league (IPL) enables one to associate players with such specific monetary values. The paper tries to evaluate the above using the data from the IPL auction till 2015 by incorporating the concepts of panel es...

  4. Indian Premier League (IPL), Cricket, Online Social Media

    OpenAIRE

    Arora, Megha; Gupta, Raghav; Kumaraguru, Ponnurangam

    2014-01-01

    In recent past online social media has played a pivotal role in sharing of information and opinions on real time events. Events in physical space are reflected in digital world through online social networks. Event based studies for such content have been widely done on Twitter in the computer science community. In this report, we performed a detailed analysis of a sports event called the Indian Premier League (IPL'13) for both Facebook and Twitter. IPL is the most popular cricket league in I...

  5. Excessive food intake, obesity and inflammation process in Zucker fa/fa rat pancreatic islets.

    Directory of Open Access Journals (Sweden)

    Myriam Chentouf

    Full Text Available Inappropriate food intake-related obesity and more importantly, visceral adiposity, are major risk factors for the onset of type 2 diabetes. Evidence is emerging that nutriment-induced β-cell dysfunction could be related to indirect induction of a state of low grade inflammation. Our aim was to study whether hyperphagia associated obesity could promote an inflammatory response in pancreatic islets leading to ß-cell dysfunction. In the hyperphagic obese insulin resistant male Zucker rat, we measured the level of circulating pro-inflammatory cytokines and estimated their production as well as the expression of their receptors in pancreatic tissue and β-cells. Our main findings concern intra-islet pro-inflammatory cytokines from fa/fa rats: IL-1β, IL-6 and TNFα expressions were increased; IL-1R1 was also over-expressed with a cellular redistribution also observed for IL-6R. To get insight into the mechanisms involved in phenotypic alterations, abArrays were used to determine the expression profile of proteins implicated in different membrane receptors signaling, apoptosis and cell cycle pathways. Despite JNK overexpression, cell viability was unaffected probably because of decreases in cleaved caspase3 as well as in SMAC/DIABLO and APP, involved in the induction and amplification of apoptosis. Concerning β-cell proliferation, decreases in important cell cycle regulators (Cyclin D1, p35 and increased expression of SMAD4 probably contribute to counteract and restrain hyperplasia in fa/fa rat islets. Finally and probably as a result of IL-1β and IL-1R1 increased expressions with sub-cellular redistribution of the receptor, islets from fa/fa rats were found more sensitive to both stimulating and inhibitory concentrations of the cytokine; this confers some physiopathological relevance to a possible autocrine regulation of β-cell function by IL-1β. These results support the hypothesis that pancreatic islets from prediabetic fa/fa rats undergo an

  6. Liver oxidation and inflammation in Fa/Fa rats fed glucomannan/spirulina-surimi.

    Science.gov (United States)

    Vázquez-Velasco, Miguel; González-Torres, Laura; López-Gasco, Patricia; Bastida, Sara; Benedí, Juana; Sánchez-Reus, María Isabel; González-Muñoz, María José; Sánchez-Muniz, Francisco J

    2014-09-15

    The effect of high-fat squid-surimi diets enriched in glucomannan or glucomannan-spirulina on lipemia, liver glutathione status, antioxidant enzymes and inflammation biomarkers was determined in Zucker Fa/Fa rats. Groups of eight rats each received for 7weeks the squid-surimi control (C), glucomannan-enriched squid-surimi (G) and glucomannan-spirulina enriched squid-surimi (GS). Liver weight, cytochrome P450 7A1 expression and cholesterolemia were decreased in G and GS vs. C, improving glutathione red-ox index (pspirulina kept those hypocholesterolemic and antioxidant effects but reduced the inflammation observed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. WWER FA modal analysis under vibration force and kinematic excitation

    International Nuclear Information System (INIS)

    Makarov, V.; Afanasyev, A.; Matvienko, I.; Tutnov, A.; Kiselev, A.; Kiselev, A.; Volkov, S.

    2008-01-01

    The approach based on mixed application of calculation and experimental methods is assumed for the analysis of WWER FA strength and stability under vibration loads typical as for reactor normal operating conditions so seismic effects. Experimental modal analysis is usually provided in air at 20 deg C, the results are FA modal characteristics: frequencies, shapes, vibration damping factor, transfer functions. Since FA is a non-linear structure, modal analysis is provided at various levels of vibration excitation. The results of experimental modal analysis are initial data for FA calculation modal model, which are used for the analysis of FA vibration strength and stability during the whole service life in the reactor. The results of experimental examination and numerical modelling of WWER-440, WWER-1000, and WWER-1500 FA dynamic characteristics and the analysis of design and operational factors influence on FA dynamic characteristics are presented in the report. This work was organized by JSC TVEL. (authors)

  8. A never-ending story: the steadily growing family of the FA and FA-like genes

    Directory of Open Access Journals (Sweden)

    Anna Gueiderikh

    2017-05-01

    Full Text Available Abstract Among the chromosome fragility-associated human syndromes that present cancer predisposition, Fanconi anemia (FA is unique due to its large genetic heterogeneity. To date, mutations in 21 genes have been associated with an FA or an FA-like clinical and cellular phenotype, whose hallmarks are bone marrow failure, predisposition to acute myeloid leukemia and a cellular and chromosomal hypersensitivity to DNA crosslinking agents exposure. The goal of this review is to trace the history of the identification of FA genes, a history that started in the eighties and is not yet over, as indicated by the cloning of a twenty-first FA gene in 2016.

  9. International Façades - CROFT. Climate Related Optimized Façade Technologies

    Directory of Open Access Journals (Sweden)

    Marcel Bilow

    2012-04-01

    Full Text Available Looking at Central European building projects illustrates an awareness of sustainability and the need to save energy. This trend is based on the finiteness of natural resources, and is thus wise to follow. Developments in this region including passive house technologies, and energy plus solutions that create more energy than they use have become realisable. But it is not increasing technological knowledge alone that supported these developments; the Central European climate makes it possible to invent technological solutions that allow for maximum comfort while maintaining low energy consumption. Other regions have experienced a building boom over the past decades that has dramatically increased city sizes. A detailed examination of such building projects illustrates that most of them strive for the international standard with a high glazing ratio in the style of the Central European examples. But how can architecture be transferred to regions with entirely different climate conditions? The answer lies in the technological possibilities we have at our disposal today. The main research question of this thesis refers to utilising the local climate. Which methods are necessary to plan a building - and a façade as the interface between the inside and the outside, in particular - while working with, not against the climate? Sailing has been used as an analogy: only with the knowledge of winds and tides can we use them to efficiently move across bodies of water. Those who have not learned or understood this will have to use a motorboat and pay the price for petrol. Chapter 2 ‘Climate zones’ describes the different climate zones and their particularities, analysed with the help of eight different boomtowns. The mild Central European climate becomes particularly apparent when compared to tropic locations such as Singapore. Here, very high average temperatures and humidity levels require that we rethink and find new solutions. In chapter 3

  10. Accuracy of references: comparison between two premier Pakistani medical journals.

    Science.gov (United States)

    Samad, Abdul; Khanzada, Tariq Wahab; Kumar, Basant; Malik, Kamran Ahmed

    2013-04-01

    To compare two premier Pakistani medical journals for errors in references of original articles published in the year 2008. All original articles of the Journal of Pakistan Medical Association and the Journal of the College of Physicians and Surgeons Pakistan published in 2008 were included in the study. References pertaining to journals were included in the study, whereas references pertaining to other sources such as books internet articles, websites and newspapers were excluded. Errors were categorised into author error, article title error, journal title error, year of publication error, volume error and page number error. The data was analysed through SPSS 16.0. References from 200 original articles (100 each from both journals) were evaluated. Only 19 (9.5%) articles were found to be free of error with no significant difference between the two journals. On evaluation of 3783 references, the overall reference error was found to be 1015 (26.8%): 531 (31%) in JPMA and 484 (23.4%) in JCPSP. The author error was the commonest error among these references (n = 490; 13%), followed by page error (n = 297; 7.9%), article title error (n = 222; 5.9%), and journal title error (n = 189; 5%). JCPSP had statistically significant more article errors, whereas JPMA had statistically significant more journal title and page errors. Reference errors constitute an avoidable but substantial lapse of medical literature. The magnitude of reference errors is much higher than expected.

  11. Time to Detection with BacT/Alert FA Plus Compared to BacT/Alert FA Blood Culture Media.

    Science.gov (United States)

    Nutman, A; Fisher Even-Tsur, S; Shapiro, G; Braun, T; Schwartz, D; Carmeli, Y

    2016-09-01

    Rapid identification of the causative pathogen in patients with bacteremia allows adjustment of antibiotic therapy and improves patient outcomes. We compared in vitro and real-life time to detection (TTD) of two blood culture media, BacT/Alert FA (FA) and BacT/Alert FA Plus (FA Plus), for the nine most common species of bacterial pathogens recovered from blood samples. Experimental data from simulated cultures was compared with microbiology records of TTD for both culture media with growth of the species of interest in clinical blood cultures. In the experimental conditions, median TTD was 3.8 hours (23.9 %) shorter using FA Plus media. The magnitude of reduction differed between species. Similarly, in real life data, FA Plus had shorter TTD than FA media; however, the difference between culture media was smaller, and median TTD was only 1 hour (8.5 %) less. We found shorter TTD with BacT/Alert FA Plus culture media, both experimentally and in real-life conditions and unrelated to antibiotic neutralization, highlighting the importance of appropriate blood culture media selection.

  12. Diabetes-associated microbiota in fa/fa rats is modified by Roux-en-Y gastric bypass

    DEFF Research Database (Denmark)

    Arora, Tulika; Seyfried, Florian; Docherty, Neil G

    2017-01-01

    Roux-en-Y gastric bypass (RYGB) and duodenal jejunal bypass (DJB), two different forms of bariatric surgery, are associated with improved glucose tolerance, but it is not clear whether the gut microbiota contributes to this effect. Here we used fa/fa rats as a model of impaired glucose tolerance ...

  13. Mass spectrometry of the lithium adducts of diacylglycerols containing hydroxy FA in castor oil and two normal FA

    Science.gov (United States)

    Castor oil can be used in industry. The molecular species of triacylglycerols containing hydroxy fatty acids (FA) in castor oil have been identified. We report here the identification of twelve diacylglycerols (DAG) containing hydroxy FA in castor oil using positive ion electrospray ionization mass ...

  14. Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.

    Science.gov (United States)

    Legette, Leecole L; Luna, Arlyn Y Moreno; Reed, Ralph L; Miranda, Cristobal L; Bobe, Gerd; Proteau, Rosita R; Stevens, Jan F

    2013-07-01

    Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4 week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses of xanthohumol at 0, 1.86, 5.64, and 16.9 mg/kg BW for 6 weeks. All rats were maintained on a high fat (60% kcal) AIN-93G diet for 3 weeks to induce severe obesity followed by a normal AIN-93G (15% kcal fat) diet for the last 3 weeks of the study. Weekly food intake and body weight were recorded. Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein-1 (MCP-1) levels were assessed using commercial assay kits. Plasma and liver tissue levels of XN and its metabolites were determined by liquid-chromatography tandem mass spectrometry. Plasma and liver tissue levels of xanthohumol were similar between low and medium dose groups and significantly (peffect on body weight and plasma glucose levels. The highest dose group (n=6) had significantly lower plasma glucose levels compared to the control group (n=6) in male but not female rats. There was also a significant decrease in body weight for male rats in the highest dose group (16.9 mg/kg BW) compared to rats that received no xanthohumol, which was also not seen for female rats. Plasma cholesterol, insulin, triglycerides, and MCP-1 as well as food intake were not affected by treatment. The findings suggest that xanthohumol has beneficial effects on markers of metabolic syndrome. Copyright © 2012. Published by Elsevier Ltd.

  15. Total Risk Integrated Methodology (TRIM) - TRIM.FaTE

    Science.gov (United States)

    TRIM.FaTE is a spatially explicit, compartmental mass balance model that describes the movement and transformation of pollutants over time, through a user-defined, bounded system that includes both biotic and abiotic compartments.

  16. TRIM.FaTE Public Reference Library Documentation

    Science.gov (United States)

    TRIM.FaTE is a spatially explicit, compartmental mass balance model that describes the movement and transformation of pollutants over time, through a user-defined, bounded system that includes both biotic and abiotic compartments.

  17. China English and ELT for English Majors

    Science.gov (United States)

    Zhang, Mingjuan

    2008-01-01

    This paper is a general study of one of varieties of English--China English and its influence on English Language Teaching (ELT) for English majors. The status of English as an International language breaks the situation in which British English or American English is the sole standard. English becomes World Englishes, taking on a plural form,…

  18. Ar-40/Ar-39 laser-probe dating of diamond inclusions from the Premier kimberlite

    Science.gov (United States)

    Phillips, D.; Onstott, T. C.; Harris, J. W.

    1989-01-01

    The results of Ar-40/Ar-39 laser-probe analyses of individual eclogitic clinopyroxene inclusions from Premier diamonds are reported which yield a mean age of 1198 + or - 14 Myr. This age agrees well with Sm-Nd and Ar-40/Ar-39 analyses on similar Premier inclusions and is indistinguishable from the inferred time of emplacement of the host kimberlite, which implies that diamond formation was essentially synchronous with kimberlite generation. The extrapolated nonradiogenic Ar-40/Ar-36 ratio of 334 + or - 102 is similar to the present-day atmospheric composition. This value is inconsistent with Sr and Nd isotopic signatures from Premier eclogite inclusions, which suggest a depleted mantle source. Preentrapment equilibration of the inclusions with an Ar-36-rich fluid is the most probable explanation for the low nonradiogenic composition.

  19. Phonologie et morphosyntaxe de l’anglais dans un produit SIC : le premier module de MACAO Phonologie et morphosyntaxe de l’anglais dans un produit SIC : le premier module de MACAO

    Directory of Open Access Journals (Sweden)

    Laurence Vincent-Durroux

    2002-12-01

    Full Text Available La préoccupation fréquente, chez les étudiants spécialistes d’autres disciplines que l’anglais, d’améliorer leur compréhension de l’anglais oral a motivé notre démarche de création d’un produit SIC (Systèmes d’Information et de Communication : MACAO (Modules d’Aide à la Compréhension de l’Anglais Oral. Le premier module, "S’entraîner à la reconnaissance", est réalisé et l’outil informatique s’est révélé particulièrement utile pour notre projet. Dans cet article, nous faisons état des difficultés récurrentes en compréhension de l’anglais oral : elles peuvent être dues à des attentes erronées fondées sur la dissymétrie entre la langue écrite et la langue orale, mais aussi à une reconnaissance difficile de certains morphèmes par l’existence de variantes phonologiques en fonction du contexte et par la proximité phonologique de certains morphèmes. Nous présentons également comment le contenu du premier module tente d’apporter des solutions à ces difficultés : en amenant les apprenants à prendre conscience du phénomène de réduction vocalique et d’inaccentuation qui touche certaines syllabes des mots aussi bien que certains éléments monosyllabiques de l’énoncé et en proposant un entraînement à la reconnaissance de ces éléments. Le module est en cours de validation avec une phase d’évaluation.French students who have English as part of their curriculum often express the wish to improve their comprehension of oral English. This led us to envisage the creation of a CALL product: MACAO (Modules to help in the comprehension of oral English. The first module has been created: "Training oneself for recognition". The computer was particularly adequate in this prospect. In this paper we present the most frequent difficulties in the comprehension of oral English: they can be related either to erroneous expectations based on the dissymmetry between the written form and the oral

  20. The Arabic Hyperbolic Pattern 'Fa??al' in Two Recent Translations of the Qur'an

    Directory of Open Access Journals (Sweden)

    Amr M. El-Zawawy

    2014-06-01

    Full Text Available The present study addresses the problem of rendering the فعال'fa??al' hyperbolic pattern into English in two recent translations of the Qur'an. Due to the variety of Qur'an translations and the large amount of hyperbolic forms of Arabic verbs recorded in the Qur'an, only two translations of the Qur'an are consulted and analyzed: these two translations, namely Saheeh International Translation (1997 and Prof. Abdel-Haleem's (2004, are distinguished by the fact that they are recent and well-received. Moreover, the investigation of hyperbolic forms is confined to the Arabic formفعال    'fa??al'. The study reveals that the Saheeh translator has applied morphological shifting in many examples while Abdel-Haleem's translation exhibits a considerable amount of syntactic transposition, coupled with paraphrasing. The test of accuracy as administered here is to give a clear picture of the need to pay particular attention to hyperboles of the form examined and other ones not analyzed here for limitations of space.

  1. Rapsodie first core manufacture. 1. part: processing plant; Fabrication du premier coeur de rapsodie. Premiere partie: l'atelier de fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Masselot, Y.; Bataller, S.; Ganivet, M.; Guillet, H.; Robillard, A.; Stosskopf, F. [Commissariat a l' Energie Atomique, Cadarache (France). Centre d' Etudes Nucleaires

    1968-07-01

    This report is the first in a series of three describing the processes, results and peculiar technical problems related to the manufacture of the first core of the fast reactor Rapsodie. A detailed study of manufacturing processes(pellets, pins, fissile sub-assemblies), the associated testings (raw materials, processed pellets and pins, sub-assemblies before delivery), manufacturing facilities and improvements for a second campaign are described. (author) [French] Ce rapport est le premier d'une serie de trois qui decrivent les procedes, les resultats et les problemes techniques particuliers de la fabrication du du premier coeur de la pile a neutrons rapides Rapsodie. Il comporte une etude detaillee des procedes de fabrication (pastilles, aiguilles, assemblages combustibles) et des methodes de controle associees (matieres premieres, pastilles et aiguilles en cours de fabrication, assemblages fissiles avant livraison), ainsi qu'une decription complete des installations de l'atelier de fabrication et les modifications apportees pour une deuxieme campagne. (auteur)

  2. 40Ar-39Ar laser probe dating of individual clinopyroxene inclusions in Premier eclogitic diamonds

    International Nuclear Information System (INIS)

    Burgess, R.; Turner, G.; Laurenzi, M.; Harris, J.W.

    1989-01-01

    The ages of seven individual clinopyroxene inclusions in Premier diamonds of eclogitic association have been determined using the 40 Ar- 39 Ar dating technique. Syngenetic inclusions weighing between 10 and 130 μg were exposed on cleaved surfaces of the diamonds and analysed using a laser probe. The inclusion ages were found to be in the range 1111±35 to 1254±38 Ma with an average of 1185±94 Ma. The ages obtained are in good agreement with previous determinations made on aggregates of eclogitic inclusions from Premier diamonds and demonstrate the applicability of the laser probe to dating individual diamond inclusions. (orig.)

  3. How to Revise, and Revise Really Well, for Premier Academic Journals

    DEFF Research Database (Denmark)

    LaPlaca, Peter J.; Lindgreen, Adam; Vanhamme, Joelle

    2018-01-01

    Most of the premier academic journals in all fields routinely have rejection rates of 80%, 95%, or higher. All journals prefer articles that make significant contributions to the field. Revising a manuscript and responding properly to the comments of reviewers and editors often is challenging....... This article discusses how to revise effectively a manuscript according to the (minor or major) comments of reviewers and editors for premier academic journals. We provide a series of tips for helping the authors in their endeavor, making the process less arduous and improving the possibility of a positive...

  4. Earphone English.

    Science.gov (United States)

    Goldsmith, Francisca

    2002-01-01

    Describes Earphone English, a student club sponsored through a partnership between Berkeley High School and the Berkeley Public Library that offers students whose primary language is not English to practice their spoken and aural English skills. Discusses the audiobooks used in the program and the importance of multicultural content and age…

  5. Metformin ameliorates diabetes but does not normalize the decreased GLUT 4 content in skeletal muscle of obese (fa/fa) Zucker rats

    DEFF Research Database (Denmark)

    Handberg, A; Kayser, L; Høyer, P E

    1993-01-01

    resistance in skeletal muscle of these animals. After 4 weeks of treatment with metformin, weight gain was not affected in either the diabetic (fa/fa) rats or the lean (Fa/-) rats. Improvement of glucose homeostasis by metformin was not associated with normalization of the GLUT 4 expression in the skeletal......We studied the expression of the glucose transporter GLUT 4 in the soleus and red gastrocnemius muscles from obese, diabetic (fa/fa) Zucker rats compared to their lean littermates (Fa/-), with and without treatment with the antidiabetic drug metformin. In the untreated groups of rats, the GLUT 4...... content in a crude membrane fraction of both the soleus and the red gastrocnemius muscles were significantly lower in the obese (fa/fa) rats (3.46 +/- 0.28 vs. 6.04 +/- 0.41, p muscle from...

  6. Doodling the Nerves: Surfacing Language Anxiety Experiences in an English Language Classroom

    Science.gov (United States)

    Siagto-Wakat, Geraldine

    2017-01-01

    This qualitative study explored the use of doodling to surface experiences in the psychological phenomenon of language anxiety in an English classroom. It treated the doodles of 192 freshmen from a premier university in Northern Luzon, Philippines. Further, it made use of phenomenological reduction in analysing the data gathered. Findings reveal…

  7. Pengaruh Pengolahan terhadap Pati Resisten Pisang Kepok (Musa Paradisiaca Fa. Typica) dan Pisang Tanduk (Musa Paradisiaca Fa. Corniculata)

    OpenAIRE

    Marsono, Yustinus

    2002-01-01

    A study on the effect processing on resistant starch (RS) content and chemical composition of kepok (Musa paradisiaca fa. typica) and tanduk banana (Musa paradisiaca fa. corniculata) has been conducted. Mature banana was steamed, steamed - cooled, steamed - frozen, dried and dried - fried and was analyzed for starch, RS, simple sugars and chemical composition. RS content was determined by enzymatic method. It was found that steaming chaned RS from 6.2 mg/g to 9.5 mg/g (53%) for kepok banana a...

  8. checkCIF/PLATON report Datablock: fa083

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. Structure factors have been supplied for datablock(s) fa083. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors ...

  9. Odenplan: a media façade design process

    DEFF Research Database (Denmark)

    Korsgaard, Henrik; Hansen, Nicolai Brodersen; Basballe, Ditte Amund

    2012-01-01

    of how to design for media façades by discussing how we have structured our design process to address specific sets of challenges outlined in previous literature in the field of media architecture. In our view, such research is valuable in that it helps establish common ground for researchers...

  10. checkCIF/PLATON report Datablock: fa289

    Indian Academy of Sciences (India)

    THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors found. CIF dictionary Interpreting this report. Datablock: fa289. Bond precision:.

  11. The 2014 presidential elections and their impact on the premier-presidential regime in Romania

    Directory of Open Access Journals (Sweden)

    Ionela Gavril

    2015-03-01

    Full Text Available First, we will demonstrate that, from an institutional perspective, Romania can labeled of premier-presidentialism regime, but the 2004 and 2009 elections have had a strong impact on the type of regime, meaning that several extra-constitutional factors led to the malfunction of the regime. Out of a total of 15 prime-minister nominations made after 1989, 8 can be considered deviations from the premier-presidential regime, their number being larger between 2004-2014 rather than in 1990-2000. The empirical analysis of the 2004-2014 period, highlighted three extra-constitutional factors that that made the premier-presidential regime be, in fact, a malfunctioning one: leadership style, crisis situations and the recent legitimacy of the president versus the parliament. By identifying the factors that influenced the regime type, we can determine some theoretical expectations following the 2014 elections. The success of a premier-presidentialism regime in Romania will be determined by the number of deviations from such a regime registered after the 2014 elections.

  12. The Management of Digital Records in the Office of the Premier of ...

    African Journals Online (AJOL)

    The study sought to investigate the management of digital records in the Office of the Premier (OTP) in the Eastern Cape Province. The objectives of the study were to determine the compliance to the legal framework, identify the requisite infrastructure for digital records management (DRM), describe the security and ...

  13. L'echographie sus-pubienne dans les anomalies du premier ...

    African Journals Online (AJOL)

    L'echographie sus-pubienne dans les anomalies du premier trimestre de la grossesse chez la femme a Lome a propos de 304 cas colliges au service de radiologie du chu-tokoin de Lome de Janvier 2005 a Decembre 2007.

  14. Joining silicon nitride to FA-129 iron aluminide

    Science.gov (United States)

    Brochu, Mathieu

    Joints between dissimilar materials are characterized particularly by compositional gradients and microstructural changes, which yield large variations in chemical, physical and mechanical properties across the joint. The joining of dissimilar materials is therefore more complex than the joining of similar materials. In this project, the joining procedure, from the interaction between the different components in a joint to the determination of the mechanical properties was applied to the Si3N4/FA-129 system. This iron aluminide intermetallic alloy (FA-129), was developed by Oak Ridge National Laboratories (ORNL) to have high temperature properties with good room temperature ductility. This intermetallic is replacing high strength ferritic stainless steel (SS) in moderate strength applications due to cost and property reasons. Joints between SS and Si3N4 are already used industrially and this project was to evaluate the potential to replace these Si3N 4/SS joints by those of Si3N4/FA-129. Broadly stated, the results obtained during this project are as follows: (I) The E2 energy for Si3N4 ceramic was calculated to be 3.01 keV. (II) The wetting of iron aluminide alloy by copper has been achieved and the spreading and reaction kinetics are influenced by the presence of Cr as alloying element. (III) The penetration and decohesion of the FA-129 microstructure is significantly reduced by the utilization of a Cu alloy containing a high titanium concentration. (IV) An active brazing alloy containing a high active element content can be fabricated by an electroless deposition technique. (V) The melting behavior of the powder was characterized and complete melting occurs in a multi-step process at different temperatures, which are a function of the heating rate. (VI) The strength of joint produced by brazing Si3N4 to itself using the composite powder reached 400 MPa. (VII) Direct brazing of Si 3N4 to FA-129 was shown to be unsuccessful and therefore a soft Cu interlayer was

  15. Metformin ameliorates diabetes but does not normalize the decreased GLUT 4 content in skeletal muscle of obese (fa/fa) Zucker rats

    DEFF Research Database (Denmark)

    Handberg, A; Kayser, L; Høyer, P E

    1993-01-01

    We studied the expression of the glucose transporter GLUT 4 in the soleus and red gastrocnemius muscles from obese, diabetic (fa/fa) Zucker rats compared to their lean littermates (Fa/-), with and without treatment with the antidiabetic drug metformin. In the untreated groups of rats, the GLUT 4...... content in a crude membrane fraction of both the soleus and the red gastrocnemius muscles were significantly lower in the obese (fa/fa) rats (3.46 +/- 0.28 vs. 6.04 +/- 0.41, p GLUT 4 expression in soleus muscle from...... the same rats were confirmed by quantitative immunofluorescence microscopy, and the results were significantly correlated with the results obtained from quantitative immunoblotting (rho = 0.70, p GLUT 4 in fa/fa rats could contribute to the well-established insulin...

  16. Penerapan Perencanaan Pajak Penghasilan pada Fa Trico Paint Factory

    Directory of Open Access Journals (Sweden)

    Stefanus Ariyanto

    2011-05-01

    Full Text Available The most important parts of government income comes from taxes, especially income taxes. The different point of view arises between government and tax payer. While the government try to increase the tax income, the taxpayers always intend to minimize their tax burden by implementing tax management/plannning. This paper is a case study in FA Trico Paint Factory (FA TPF that try to reperforming company’s income tax return preparation with the main purpose to minimize company tax burden, while it is still comply with tax regulations in Indonesia. This approach could be an alternative for the company to restate it’s annual income tax return, to avoic fines and charges for not comply with the regulations, and minimize it’s income tax expense by approximately 10% per year. 

  17. Extramural English

    DEFF Research Database (Denmark)

    Jensen, Signe Hannibal

    activities are more supportive of language learning than others, i.e. gaming, watching television, music, etc. Finally, a qualitative gaming study will be carried out to explore what goes on linguistically when very young children game in English together: type of interaction between players...... and with the game and if this interaction can be seen to support their English language learning. Preliminary results indicate that although children use / are exposed to English in a range of different contexts and through a variety of modalities (internet, console/PC games, music etc.), the one activity...... that seems to have the most impact on children’s English learning is gaming....

  18. Optimizing Maintenance Manpower for USMC F/A-18 Squadrons

    Science.gov (United States)

    2016-06-01

    never greater than ten, it is extremely important to manage the manpower very carefully as removing a Marine of any skill level, highlighted by the 47...requiring certification by a member of the most experienced category before an aircraft can fly. This thesis formulates the Manpower Validation Planner...in an F/A-18 maintenance department have sufficient manpower available, but that two WCs are overtasked. Additional analysis shows the

  19. Onset of genetic obesity in the absence of hyperphagia during the first week of life in the Zucker rat (fa/fa).

    Science.gov (United States)

    Boulangé, A; Planche, E; de Gasquet, P

    1979-09-01

    The aim of this study was to discover which of three major abnormalities of the genetically obese Zucker rat (fa/fa), namely hyperphagia, excess adiposity, and hyperlipidemia, is the first to appear prior to manifest obesity, i.e., before weaning. Suckling fa/fa rats, bred from heterozygous parents, were detected by sizing fat cells obtained from an inguinal fat pad biopsy. Cell hypertrophy was observed in fa/fa rats, compared to Fa/-littermates of the same sex, as soon as 5-7 days after birth. Prediction of fa/fa genotype at this age by this method was assessed using a series of 80 pups and proved to be totally successful. The identity of the "predicted" obese pups was confirmed morphologically at 6 weeks of age. Food (milk) intake was estimated from water turnover rates determined on 86 pups aged 2-8 days using tritiated water. The results show that 7-day-old fa/fa rats had heavier inguinal fat pads with larger adipocytes and higher lipoprotein lipase activity than their lean controls. There was no genotype effect on water intake adjusted to body weight during the first week of life. Moreover weight of stomach contents and triglyceridemia were similar in all animals at 7 days. These results show that excess adiposity develops in the fa/fa rat during the first week of life, before hypertriglyceridemia and hyperphagia, and raises the question of whether this adiposity results from a defect in energy expenditure or an abnormality of fat cell storage capacity, or both.

  20. CALL English

    DEFF Research Database (Denmark)

    Barlach, Else

    This multimedia program of English grammar caters specifically for Danish students at Bachelor level. The handbook introduces students to well-established grammatical terminology within the traditional areas of English grammar, and the CD-ROM, which contains about 120 exercises, offers students...

  1. Opuntia ficus indica (nopal) attenuates hepatic steatosis and oxidative stress in obese Zucker (fa/fa) rats.

    Science.gov (United States)

    Morán-Ramos, Sofía; Avila-Nava, Azalia; Tovar, Armando R; Pedraza-Chaverri, José; López-Romero, Patricia; Torres, Nimbe

    2012-11-01

    Nonalcoholic fatty liver disease (NAFLD) is associated with multiple factors such as obesity, insulin resistance, and oxidative stress. Nopal, a cactus plant widely consumed in the Mexican diet, is considered a functional food because of its antioxidant activity and ability to improve biomarkers of metabolic syndrome. The aim of this study was to assess the effect of nopal consumption on the development of hepatic steatosis and hepatic oxidative stress and on the regulation of genes involved in hepatic lipid metabolism. Obese Zucker (fa/fa) rats were fed a control diet or a diet containing 4% nopal for 7 wk. Rats fed the nopal-containing diet had ∼50% lower hepatic TG than the control group as well as a reduction in hepatomegaly and biomarkers of hepatocyte injury such as alanine and aspartate aminotransferases. Attenuation of hepatic steatosis by nopal consumption was accompanied by a higher serum concentration of adiponectin and a greater abundance of mRNA for genes involved in lipid oxidation and lipid export and production of carnitine palmitoyltransferase-1 and microsomal TG transfer proteins in liver. Hepatic reactive oxygen species and lipid peroxidation biomarkers were significantly lower in rats fed nopal compared with the control rats. Furthermore, rats fed the nopal diet had a lower postprandial serum insulin concentration and a greater liver phosphorylated protein kinase B (pAKT):AKT ratio in the postprandial state. This study suggests that nopal consumption attenuates hepatic steatosis by increasing fatty acid oxidation and VLDL synthesis, decreasing oxidative stress, and improving liver insulin signaling in obese Zucker (fa/fa) rats.

  2. A protein prioritization approach tailored for the FA/BRCA pathway.

    Directory of Open Access Journals (Sweden)

    Anneke Haitjema

    Full Text Available Fanconi anemia (FA is a heterogeneous recessive disorder associated with a markedly elevated risk to develop cancer. To date sixteen FA genes have been identified, three of which predispose heterozygous mutation carriers to breast cancer. The FA proteins work together in a genome maintenance pathway, the so-called FA/BRCA pathway which is important during the S phase of the cell cycle. Since not all FA patients can be linked to (one of the sixteen known complementation groups, new FA genes remain to be identified. In addition the complex FA network remains to be further unravelled. One of the FA genes, FANCI, has been identified via a combination of bioinformatic techniques exploiting FA protein properties and genetic linkage. The aim of this study was to develop a prioritization approach for proteins of the entire human proteome that potentially interact with the FA/BRCA pathway or are novel candidate FA genes. To this end, we combined the original bioinformatics approach based on the properties of the first thirteen FA proteins identified with publicly available tools for protein-protein interactions, literature mining (Nermal and a protein function prediction tool (FuncNet. Importantly, the three newest FA proteins FANCO/RAD51C, FANCP/SLX4, and XRCC2 displayed scores in the range of the already known FA proteins. Likewise, a prime candidate FA gene based on next generation sequencing and having a very low score was subsequently disproven by functional studies for the FA phenotype. Furthermore, the approach strongly enriches for GO terms such as DNA repair, response to DNA damage stimulus, and cell cycle-regulated genes. Additionally, overlaying the top 150 with a haploinsufficiency probability score, renders the approach more tailored for identifying breast cancer related genes. This approach may be useful for prioritization of putative novel FA or breast cancer genes from next generation sequencing efforts.

  3. Football versus football: effect of topic on /r/ realization in American and English sports fans.

    Science.gov (United States)

    Love, Jessica; Walker, Abby

    2013-12-01

    Can the topic of a conversation, when heavily associated with a particular dialect region, influence how a speaker realizes a linguistic variable? We interviewed fans of English Premier League soccer at a pub in Columbus, Ohio. Nine speakers of British English and eleven speakers of American English were interviewed about their favorite American football and English soccer teams. We present evidence that the soccer fans in this speech community produce variants more consistent with Standard American English when talking about American football than English soccer. Specifically, speakers were overall more /r/-ful (F3 values were lower in rhotic environments) when talking about their favorite American football team. Numeric trends in the data also suggest that exposure to both American and British English, being a fan of both sports, and task may mediate these effects.

  4. Una donna de Sibilla Aleramo: le premier grand roman féministe italien ?

    Directory of Open Access Journals (Sweden)

    Alison Carton-Vincent

    2009-06-01

    Full Text Available A travers l’étude du roman considéré comme le manifeste du féminisme italien, Una donna, il s’agit de caractériser la pensée féministe de l’auteure, Sibilla Aleramo, et de voir en quoi celle-ci reflète les débats du premier XXe siècle sur « la questione muliebre » (notamment au sujet de la maternité, des normes de genre, et plus généralement de l’émancipation féminine.En 1906, Sibilla Aleramo publie son premier ouvrage, Una donna. Ce roman à la première personne retrace la vie d’une jeune fe...

  5. Morbi-mortalite au cours du premier trimestre de la grossesse a ...

    African Journals Online (AJOL)

    Le but de cette étude était de déterminer la prévalence des complications de la grossesse au premier trimestre, identifier leurs facteurs de risque et évaluer le pronostic immédiat. L\\'étude prospective, descriptive et multicentrique, conduite sur un an, du 1er Janvier 2005 au 31 Décembre 2005 dans les trois principales ...

  6. A Hedonic Model of Player Wage Determination from the Indian Premier League Auction#

    OpenAIRE

    Liam J A Lenten; Wayne Geerling; László Kónya

    2010-01-01

    A range of cross-sectional models are estimated with a view to establishing the factors that determine the valuation of professional athletes in a highly-specialised sport, with an application to crickets Indian Premier League (IPL). We distinguish between personal characteristic and playing ability factors, and with respect to the former, between ability in different forms of the sport. We find a number of interpretable variables that have explanatory power over auction values, while decompo...

  7. Analisis Kualitas Pelayanan terhadap Kepuasan Konsumen Jasa Hotel Santika Premiere Semarang

    OpenAIRE

    Dewangga, Nandy; Hidayat, Wahyu; Widiartanto, Widiartanto

    2014-01-01

    The competition of global business today focusing on consumers is a strategic choice in business world in order to survive. For example, the tight competition of business in the company of hotel services is by improving the service quality to consumers. The problems in this research were the decreasing number of hotel service users and the increasing number of consumer complaint as the service users of Santika Premiere Hotel in Semarang from year to year. The aims of this research were to ide...

  8. Un premier service mobile en Égypte qui relie les petits exploitants ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Un premier service mobile en Égypte qui relie les petits exploitants aux acheteurs. Un homme qui parle sur un téléphone mobile. Les petits exploitants agricoles dominent l'agriculture égyptienne, mais leur manque de connaissances en matière de commercialisation et de compétences techniques, ainsi qu'une mauvaise ...

  9. Case study: Muscle atrophy and hypertrophy in a premier league soccer player during rehabilitation from ACL injury.

    Science.gov (United States)

    Milsom, Jordan; Barreira, Paulo; Burgess, Darren J; Iqbal, Zafar; Morton, James P

    2014-10-01

    The onset of injury and subsequent period of immobilization and disuse present major challenges to maintenance of skeletal muscle mass and function. Although the characteristics of immobilization-induced muscle atrophy are well documented in laboratory studies, comparable data from elite athletes in free-living conditions are not readily available. We present a 6-month case-study account from a professional soccer player of the English Premier League characterizing rates of muscle atrophy and hypertrophy (as assessed by DXA) during immobilization and rehabilitation after ACL injury. During 8 weeks of inactivity and immobilization, where the athlete adhered to a low carbohydrate-high protein diet, total body mass decreased by 5 kg attributable to 5.8 kg loss and 0.8 kg gain in lean and fat mass, respectively. Changes in whole-body lean mass was attributable to comparable relative decreases in the trunk (12%, 3.8 kg) and immobilized limb (13%, 1.4 kg) whereas the nonimmobilized limb exhibited smaller declines (7%, 0.8 kg). In Weeks 8 to 24, the athlete adhered to a moderate carbohydrate-high protein diet combined with structured resistance and field based training for both the lower and upper-body that resulted in whole-body muscle hypertrophy (varying from 0.5 to 1 kg per week). Regional hypertrophy was particularly pronounced in the trunk and nonimmobilized limb during weeks 8 to 12 (2.6 kg) and 13 to 16 (1.3 kg), respectively, whereas the previously immobilized limb exhibited slower but progressive increases in lean mass from Week 12 to 24 (1.2 kg). The athlete presented after the totality of the injured period with an improved anthropometrical and physical profile.

  10. Logistique de transport pour le projet LHC enseignements des premiers secteurs

    CERN Document Server

    Prodon, S

    2003-01-01

    Ce papier dresse un premier bilan de la logistique de transport mise en place pour l'installation du LHC. Les moyens de planification mis en oeuvre seront tout d'abord évoqués avec notamment les réunions avec les groupes utilisateurs, l'élaboration de procédures de transport, la génération de listings d'articles à transporter ou encore l'établissement d'un planning des ressources. Cependant, les premiers travaux d'installation du LHC ont fait apparaître des divergences importantes entre le planning logistique établi et la réalité du terrain. Ces écarts seront analysés, qu'il s'agisse de différences sur le volume de matériel à acheminer, d'opérations non planifiées, de changements de plannings entraînant de longues et délicates traversées de chantiers ou de manque de planification des besoins en personnel dans certaines zones. Tous ces enseignements acquis au cours des premiers travaux devraient permettre de dégager des voies d'amélioration à mettre en place pour les prochains secteur...

  11. Integrated controller 'MICREX-SX' system and FA application software; Togo controller 'MICREX-SX' system ni okeru FA application software tono renkei

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, C.; Takeda, Y. [Fuji Electric Co. Ltd., Tokyo (Japan)

    2000-02-10

    Recent manufacturing industries have more often combined the technologies and products of various vendors to structure flexible, efficient, low-cost, factory automation (FA) application software. At the same time, standardization for FA systems also has been promoted. In view of the present status of manufacturing industries, this paper describes an example of data linking between FA application software and the programmable controller in the MICREX-SX system. (author)

  12. Deterministic Assessment of Future Costs for Dismantling (FA)

    International Nuclear Information System (INIS)

    Vasko, Marek

    2012-03-01

    The main objective of the report is to provide an re-evaluation of cost calculations by OMEGA code for the Intermediate Storage for Spent Fuel in Studsvik (FA facility) using up-to-date Swedish labour cost unit factors and available up-to-date Swedish (or international) cost unit factors for consumables, materials and substances. Furthermore, evolution of other OMEGA database parameters concerning cost calculations e.g. manpower unit factors and workgroups parameters are taken into account. This report follows up former project which introduced tentative calculations of main decommissioning parameters such as costs, manpower and exposure of personnel for activities of older nuclear facility decommissioning in Sweden represented by FA Facility in Studsvik by means of calculation code OMEGA. The project demonstrated an implementation of advanced costing methodology based on PSL structure format to achieve transparent, traceable and comparable estimates even for older nuclear facilities like FA Facility in Studsvik. This former project used Slovak origin labour costs unit factors and other cost unit factors. After successful completion of this project, there was an intent of SSM to reevaluate calculations using an up-to-date Swedish labour cost data and also available Swedish consumables and materials cost data if available. Within this report re-calculations of main decommissioning parameters using available Swedish data are presented in structure according to Proposed Standardized List of Items for Costing Purposes. Calculations are made for decommissioning scenario with post-dismantling decontamination and steel radwaste melting technologies available at the site. All parameters are documented and summed up in both table and graphic forms in text and Annexes. Further, comparison of calculated results with previous calculations together with discussion is provided

  13. Deterministic Assessment of Future Costs for Dismantling (FA)

    Energy Technology Data Exchange (ETDEWEB)

    Vasko, Marek [DECOM, Trnava (Slovakia)

    2012-11-01

    The main objective of the report is to provide an re-evaluation of cost calculations by OMEGA code for the Intermediate Storage for Spent Fuel in Studsvik (FA facility) using up-to-date Swedish labour cost unit factors and available up-to-date Swedish (or international) cost unit factors for consumables, materials and substances. Furthermore, evolution of other OMEGA database parameters concerning cost calculations e.g. manpower unit factors and workgroups parameters are taken into account. This report follows up former project which introduced tentative calculations of main decommissioning parameters such as costs, manpower and exposure of personnel for activities of older nuclear facility decommissioning in Sweden represented by FA Facility in Studsvik by means of calculation code OMEGA. The project demonstrated an implementation of advanced costing methodology based on PSL structure format to achieve transparent, traceable and comparable estimates even for older nuclear facilities like FA Facility in Studsvik. This former project used Slovak origin labour costs unit factors and other cost unit factors. After successful completion of this project, there was an intent of SSM to reevaluate calculations using an up-to-date Swedish labour cost data and also available Swedish consumables and materials cost data if available. Within this report re-calculations of main decommissioning parameters using available Swedish data are presented in structure according to Proposed Standardized List of Items for Costing Purposes. Calculations are made for decommissioning scenario with post-dismantling decontamination and steel radwaste melting technologies available at the site. All parameters are documented and summed up in both table and graphic forms in text and Annexes. Further, comparison of calculated results with previous calculations together with discussion is provided.

  14. Health Improvement for Men and Hard-to-Engage-Men Delivered in English Premier League Football Clubs

    Science.gov (United States)

    Pringle, Andy; Zwolinsky, Stephen; McKenna, James; Robertson, Steven; Daly-Smith, Andy; White, Alan

    2014-01-01

    Unhealthy behaviours represent modifiable causes of non-communicable disease. In men, concern focuses on those (i) demonstrating the poorest health, exacerbated by a lack of awareness of the risks that their lifestyles pose and (ii) who neither consult their doctor nor use health services. Classed as "hard-to-engage", distinctive…

  15. FaPOD27 functions in the metabolism of polyphenols in strawberry fruit (Fragaria sp.

    Directory of Open Access Journals (Sweden)

    Su-Ying eYeh

    2014-10-01

    Full Text Available The strawberry (Fragaria × ananassa is one of the most preferred fresh fruit worldwide, accumulates numerous flavonoids but has limited shelf life due to excessive tissue softening caused by cell wall degradation. Since lignin is one of the polymers that strengthen plant cell walls and might contribute to some extent to fruit firmness monolignol biosynthesis was studied in strawberry fruit. Cinnamoyl-CoA reductase (CCR, cinnamyl alcohol dehydrogenase (CAD, and a peroxidase (POD27 gene were strongly expressed in red, ripe fruit whereas a second POD gene was primarily expressed in green, immature fruit. Moreover, FaPOD27 transcripts were strongly and constitutively induced in fruits exposed to Agrobacterium infection. Gene expression levels and enzymatic activities of FaCCR and FaCAD were efficiently suppressed through RNAi in FaCCR- and FaCAD-silenced strawberries. Besides, significantly elevated FaPOD transcript levels were detected after agroinfiltration of pBI-FaPOD constructs in fruits. At the same time, levels of G-monomers were considerably reduced in FaCCR-silenced fruits whereas the proportion of both G- and S-monomers decisively decreased in FaCAD-silenced and pBI-FaPOD fruits. Development, firmness, and lignin level of the treated fruits were similar to pBI-intron control fruits, presumably attributed to increased expression levels of FaPOD27 upon agroinfiltration. Additionally, enhanced firmness, accompanied with elevated lignin levels, was revealed in chalcone synthase-deficient fruits (CHS-, independent of down- or up-regulation of individual and combined FaCCR, FaCAD, and FaPOD genes by agroinfiltration, when compared to CHS-/pBI-intron control fruits. These approaches provide further insight into the genetic control of flavonoid and lignin synthesis in strawberries. The results suggest that FaPOD27 is a key gene for lignin biosynthesis in strawberry fruit and thus to improving the firmness of strawberries.

  16. Whole exome sequencing reveals concomitant mutations of multiple FA genes in individual Fanconi anemia patients.

    Science.gov (United States)

    Chang, Lixian; Yuan, Weiping; Zeng, Huimin; Zhou, Quanquan; Wei, Wei; Zhou, Jianfeng; Li, Miaomiao; Wang, Xiaomin; Xu, Mingjiang; Yang, Fengchun; Yang, Yungui; Cheng, Tao; Zhu, Xiaofan

    2014-05-15

    Fanconi anemia (FA) is a rare inherited genetic syndrome with highly variable clinical manifestations. Fifteen genetic subtypes of FA have been identified. Traditional complementation tests for grouping studies have been used generally in FA patients and in stepwise methods to identify the FA type, which can result in incomplete genetic information from FA patients. We diagnosed five pediatric patients with FA based on clinical manifestations, and we performed exome sequencing of peripheral blood specimens from these patients and their family members. The related sequencing data were then analyzed by bioinformatics, and the FANC gene mutations identified by exome sequencing were confirmed by PCR re-sequencing. Homozygous and compound heterozygous mutations of FANC genes were identified in all of the patients. The FA subtypes of the patients included FANCA, FANCM and FANCD2. Interestingly, four FA patients harbored multiple mutations in at least two FA genes, and some of these mutations have not been previously reported. These patients' clinical manifestations were vastly different from each other, as were their treatment responses to androstanazol and prednisone. This finding suggests that heterozygous mutation(s) in FA genes could also have diverse biological and/or pathophysiological effects on FA patients or FA gene carriers. Interestingly, we were not able to identify de novo mutations in the genes implicated in DNA repair pathways when the sequencing data of patients were compared with those of their parents. Our results indicate that Chinese FA patients and carriers might have higher and more complex mutation rates in FANC genes than have been conventionally recognized. Testing of the fifteen FANC genes in FA patients and their family members should be a regular clinical practice to determine the optimal care for the individual patient, to counsel the family and to obtain a better understanding of FA pathophysiology.

  17. Development and validation of a French Canadian version of the Falls Behavioral (FaB) Scale.

    Science.gov (United States)

    Filiatrault, Johanne; Demers, Louise; Parisien, Manon; Lorthios-Guilledroit, Agathe; Kaegi, Christine; Ménard, Isabelle; Paniconi, Mary-Grace; St-Laurent, Caroline

    2014-01-01

    To develop a French Canadian version of the Falls Behavioral (FaB) Scale and examine its psychometric properties. The FaB was adapted in French Canadian (FaB-FC) and validated according to standard guidelines for cross-cultural adaptation of questionnaires. The internal consistency and construct validity of the FaB-FC were studied among 64 community-dwelling adults aged 60 and over. The concurrent validity and test-retest reliability of the FaB-FC were respectively examined among subsamples including 31 bilingual and 33 unilingual participants. The FaB-FC showed good concurrent validity with the original FaB (ICC2 = 0.94; 0.87-0.97), as well as good test-retest reliability (ICC2 = 0.94; 0.88-0.97). The FaB-FC also demonstrated high internal consistency (α = 0.91). Moreover, analyses showed significant associations of the FaB-FC scores with fear of falling and balance confidence scores, attesting to its construct validity. This study provides evidence that the FaB-FC has sound psychometric properties. Since falls are associated with multiple risk factors, including behavioral factors, the FaB-FC is undoubtedly a relevant assessment tool for clinicians and researchers working toward fall prevention among French-speaking community-dwelling seniors. Fall-related behaviors should be addressed in the assessment of community-dwelling seniors' fall risks. Like the original FaB, the French Canadian version of the tool (FaB-FC) is valid and reliable for assessing fall-related behaviors. The FaB-FC is a relevant complementary assessment tool for identifying seniors at risk for falls. The FaB-FC could also be useful in guiding fall prevention interventions and measuring the impact of these interventions on seniors' behaviors.

  18. Solution Validation for a Double Façade Prototype

    Directory of Open Access Journals (Sweden)

    Pau Fonseca i Casas

    2017-12-01

    Full Text Available A Solution Validation involves comparing the data obtained from the system that are implemented following the model recommendations, as well as the model results. This paper presents a Solution Validation that has been performed with the aim of certifying that a set of computer-optimized designs, for a double façade, are consistent with reality. To validate the results obtained through simulation models, based on dynamic thermal calculation and using Computational Fluid Dynamic techniques, a comparison with the data obtained by monitoring a real implemented prototype has been carried out. The new validated model can be used to describe the system thermal behavior in different climatic zones without having to build a new prototype. The good performance of the proposed double façade solution is confirmed since the validation assures there is a considerable energy saving, preserving and even improving interior comfort. This work shows all the processes in the Solution Validation depicting some of the problems we faced and represents an example of this kind of validation that often is not considered in a simulation project.

  19. Development of a Holistic Evaluation System for BIPV Façades

    Directory of Open Access Journals (Sweden)

    Thorsten Schuetze

    2015-06-01

    Full Text Available Façades with building-integrated photovoltaics (BIPV have the advantage that they can produce renewable electric energy. Compared with conventional façades, BIPV façades have therefore a valuable additional property that can generally contribute to increasing the degree of sustainability of buildings. A holistic assessment system for BIPV façade systems for office and administration buildings was developed in the framework of the project “MULTIELEMENT II” at the Fraunhofer Institute for Wind Energy and Energy System Technology (IWES in Kassel, Germany. The aim of this research was a comparison of conventional façade systems with BIPV façade systems regarding different technical, economical, sustainability, and design criteria. This paper discusses the basic conditions for a holistic evaluation of BIPV façades in comparison with conventional façades. A method for the execution of a holistic evaluation and characteristic values for a comparison interpretation of results is presented. Façade systems are evaluated regarding both quantifiable and non-quantifiable properties by means of a Microsoft Excel-based evaluation tool. The tool facilitates the comparison and evaluation of planned or built façades with and without BIPV. The detailed evaluation results aim to facilitate the certification of BIPV façade systems in the framework of sustainable building certification systems such as the German DGNB.

  20. The Englishness of English Sedilia

    Directory of Open Access Journals (Sweden)

    James Alexander Cameron

    2017-06-01

    Full Text Available Sedilia are the ceremonial seats of the priest, deacon, and subdeacon placed to the south of the altar. In Gothic church architecture, they typically take the form of three deep niches, recessed into the thickness of the wall, surmounted by arches and separated by shafts. These types of sedilia are most well-known from English churches of the thirteenth and fourteenth centuries. This essay looks to explain why sedilia became so popular in England, through a consideration of trends in English architecture. With the help of Nikolaus Pevsner’s characterization of the country’s art from The Englishness of English Art, it will argue that the basic decorative language of sedilia is entrenched in trends first developed in the Anglo-Norman Romanesque. It will also suggest, however, that regional variations in the distribution of sedilia complicate the idea of a single “national style”.

  1. Status and prospects of the FaCT project

    International Nuclear Information System (INIS)

    Nagaoki, Yoshihiro; Kikuchi, Shin; Ichimiya, Masakazu

    2008-01-01

    'Fast Reactor Cycle Technology Development (FaCT)' project has been conducted since 2006. In this project, design study and research and development (R and D) on innovative technologies for fast reactor (FR) cycle system are implemented in order to present the conceptual designs of commercial and demonstration facilities by 2015 and start operating demonstration fast reactor in 2025. The R and Ds has been stepped forward into the development stage to establish the realization of innovative technologies which bring excellent performance to fast reactor cycle system. The purpose of R and D by 2010 is to decide whether innovative technologies shall be adopted. So promoting R and D of FR, the project governance was organized. Furthermore, several possible R and D have been effectively carried out within the frameworks of international cooperation, such as Global Nuclear Energy Partnership (GNEP), Generation IV International Forum (GIF), and International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). (author)

  2. ENGLISH TRAINING

    CERN Multimedia

    2003-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch PLACES AVAILABLE Writing Professional Documents in English This course is designed for people with a good level of spoken English who need to improve their professional writing (administrative, scientific, technical). Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) Date and timetable will be fixed when there are sufficient participants enrolled. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their sp...

  3. English Graphic

    OpenAIRE

    2012-01-01

    English Graphic is a book of essays on the subject of illustration, with the focus entirely on English artists using graphic media; drawings, prints and watercolours. As editor, I built on a schedule Tom drew up. It contains essays drawn from a variety of sources: the Great Works column, reviews, catalogue essays, and previously unpublished material. The historical span of the book is broad – from the Winchester Psalter Hellmouth to Harry Beck’s London Underground Map and Dom Sylvester Houéda...

  4. Remarkable features of ovarian morphology and reproductive hormones in insulin-resistant Zucker fatty (fa/fa rats

    Directory of Open Access Journals (Sweden)

    Manase Kengo

    2010-06-01

    Full Text Available Abstract Background Zucker fatty (fa/fa rats are a well-understood model of obesity and hyperinsulinemia. It is now thought that obesity/hyperinsulinemia is an important cause of endocrinological abnormality, but to date there have been no reports on the changes in ovarian morphology or the ovarian androgen profile in rat models of obesity and insulin resistance. Methods In this study we investigated the effects of obesity and hyperinsulinemia on ovarian morphology and the hormone profile in insulin-resistant Zucker fatty rats (5, 8, 12 and 16 weeks of age, n = 6-7. Results Ovaries from 5-week-old fatty rats had significantly greater total and atretic follicle numbers, and higher atretic-to-total follicle ratios than those from lean rats. Ovaries from 12- and 16-week-old fatty rats showed interstitial cell hyperplasia and numerous cysts with features of advanced follicular atresia. In addition, serum testosterone and androstenedione levels significantly declined in fatty rats from age 8 to 16 weeks, so that fatty rats showed significantly lower levels of serum testosterone (12 and 16 weeks and androstenedione (all weeks than lean rats. This may reflect a reduction of androgen synthesis during follicular atresia. Serum adiponectin levels were high in immature fatty rats, and although the levels declined significantly as they matured, it remained significantly higher in fatty rats than in lean rats. On the other hand, levels of ovarian adiponectin and its receptors were significantly lower in mature fatty rats than in lean mature rats or immature fatty rats. Conclusions Our findings indicate that ovarian morphology and hormone profiles are significantly altered by the continuous insulin resistance in Zucker fatty rats. Simultaneously, abrupt reductions in serum and ovarian adiponectin also likely contribute to the infertility seen in fatty rats.

  5. English Downfall

    Science.gov (United States)

    Theamishaugur

    2009-01-01

    In a remix of the infamous Hitler meme--taking a scene from the movie, "Downfall" (2005), and adding subtitles appropriate (in this case) for "Kairos" readers--theamishaugur makes a pointed, humorous (to some) commentary on the status of multimodal composition scholars in English departments during job market season.

  6. English Training

    CERN Multimedia

    2003-01-01

    General and Professional English Courses The next session will take place: from 03 March to 28 June 2003 (2 weeks break at Easter). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel.73127 or Mr. Liptow: tel.72957. Writing Professional Documents in English This course is designed for people with a good level of spoken English. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Mrs. Tessa Osborne: Tessa.Osborne@cern. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, rol...

  7. English Training

    CERN Multimedia

    2003-01-01

    General and Professional English Courses The next session will take place: from 03 March to 28 June 2003 (2 weeks break at Easter). These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel.73127 or Mr. Liptow: tel.72957. Writing Professional Documents in English This course is designed for people with a good level of spoken English. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Mrs. Tessa Osborne: Tessa.Osborne@cern. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-p...

  8. English Phonetics

    DEFF Research Database (Denmark)

    for phoneticians, phonologists, and other linguists to locate and use, English Phonetics: Twentieth-Century Developments is a veritable treasure-trove. The gathered works are reproduced in facsimile, giving users a strong sense of immediacy to the texts and permitting citation to the original pagination...

  9. English courses

    CERN Document Server

    HR Department

    2010-01-01

    New courses University of Cambridge ESOL examination course We will be starting two new courses in October leading to the Cambridge First Certificate in English (level B2 of the European Framework) and the Cambridge Advanced English (level C1) examinations. These courses will consist of two semesters of 15 weeks with two two-hourly classes per week. There will be an average of eight students per class. Normally the examination will be taken in June 2011 but strong participants could take it earlier. People wishing to take these courses should enrol: http://cta.cern.ch/cta2/f?p=110:9:1927376177842004::NO::X_COURSE_ID,X_STATUS:4133%2CD and they will then be required to take a placement test to check that their level of English is of an appropriate level. Please note that we need a minimum of seven students enrolled to open a session. For further information please contact Tessa Osborne 72957. General and Professional English Courses The next session will take place: From 4th October 2010 to 5th Feb...

  10. Report to New England Governors and Eastern Canadian Premiers on climate change projects

    International Nuclear Information System (INIS)

    2002-08-01

    The Premiers-Governors energy discussions are aimed at promoting joint energy cooperation between provinces and states. This report outlines the major accomplishments in the implementation of the Climate Change Action Plan adopted by the Conference in 1998. The project priorities for the coming year are also outlined. In 2001, the New England Governors (NEG) and the Eastern Canadian Premiers (ECP) directed the Environment Committee and the Northeast International Committee on Energy (NICE) to implement a plan to develop a regional emissions inventory so that participating jurisdictions would have common data for measuring progress. The plan also identified specific climate actions that could be readily implemented. This report describes the results of 5 working groups which were created to focus on the following potential categories: energy, transportation, inventory and registry, adaptation, and 'lead by example'. In addition to the working groups, the Climate Change Steering Committee developed 4 proposals for consideration for implementation. These were the LED Traffic Light Proposal, the College and University Partnerships in Emissions Reductions, State/Provincial Purchasing Programs for High Efficiency-Low Emission Office Equipment, and Use of Cleaner, More Energy-Efficient Vehicles in State/Provincial Fleets. The Steering Committee will also pursue other tasks in the coming year, including the study of other proposals for cost-effective measures that could contribute to the goals of the Climate Change Action Plan, examine Internet options for coordinating internal project work, examine opportunities to pursue climate action, and identify opportunities to improve vehicle fuel efficiency

  11. ABOUT THE SMART SPORTS DEVELOPMENT. EVIDENCE FROM THE UK PREMIERE LEAGUE

    Directory of Open Access Journals (Sweden)

    Vlad Ionut Dumitrache

    2016-11-01

    Full Text Available Smart economy implies the development of key factors like global economy growth, competition, economic progress, economic prosperity, innovation. In the European top-level football, like the case of the British Premier League, financial indicators have demonstrated that the factors that define smart economy can be identified. The new rules of the financial fair-play policies and the ever growing revenues for television rights have created a new market in sports economy, one that identifies itself with the criteria identifies in studies regarding smart economy. This paper comparatively examines the determinants of four indicators of the football team quality in the British Premier League, in order to find out whether a common set of potential determinants could be effective in improving all four indicators of quality, without worsening any of them. This allows finding what measures undertaken at the level of football teams could raise the football team quality. Considering the subjective and multidimensional nature of the football team quality, we first propose four indicators that might be appropriate to define this latent summative measure. Then we select a number of four potentially common determinants of the football team quality, and finally discuss the empirical results, based on panel generalized least squares regression models. The television broadcasting rights are found to be the most important determinant of the football team quality.

  12. RANKING THE SPECTATORS’ DIFFICULTIES IN PURCHASING ELECTRONIC TICKETS OF FOOTBALL PREMIER LEAGUE

    Directory of Open Access Journals (Sweden)

    Ahmad Narimani

    2017-04-01

    Full Text Available This study aimed to rank the spectators’ difficulties in buying electronic tickets of football premier league matches at Azadi stadium. The population consisted of all spectators of Esteghlal-Persepolis match in the fifteenth league at Azadi stadium (N= 100000. According to Morgan table and using simple random sampling method, 500 participants were selected as sample. A researcher-made questionnaire was used for collecting the data; its face validity was confirmed by 15 experts and performing a pilot study on 30 subjects, its Cronbach’s alpha was calculated to be 0.86. Using SPSS 22, the descriptive and inferential (including Friedman test statistics was applied for analyzing the data. The findings showed that there was a significant difference between rankings of difficulties in buying electronic tickets of Football premier league matches at Azadi Stadium. The difficulties were ranked as: problem in ticket systems, early selling out of electronic tickets, lack of confidence to electronic ticket sale, lack of skill to work with the internet, low speed of internet, and lack of access to the internet

  13. Making out in English (English phrasebook)

    CERN Document Server

    Crownover, Richard

    2011-01-01

    Making Out in English is a fun, accessible and thorough English phrase book and guide to the English language as it's really spoken. If you are a student, businessman or tourist traveling to the English speaking world and would like to have an authentic and meaningful experience, the key is being able to speak like a local. This friendly and easy-to-use English phrasebook makes this possible. Making Out in English has been revised and redesigned to act as a guide to modern colloquial English for use in everyday informal interactions—giving access to the sort of catchy English expressions that

  14. Comparing R1233zd And R245fa For Low Temperature ORC Applications

    OpenAIRE

    Datla, Bala V.; Brasz, Joost J.

    2014-01-01

    The majority of recently introduced ORC systems use R245fa as working fluid. The lower saturation pressures of R245fa versus R134a allowed the use of existing HVAC electric motors, compressors, evaporators and condensers after minor modifications as ORC electric generators, turbines/expanders, boilers and condensers. At elevated saturation temperatures R245fa turbine/expander equipment matches the power density of R134a HVAC compressors equipment. Refrigerants with still lower saturation pres...

  15. Effect of façade systems on the performance of cooling ceilings: In situ measurements

    Directory of Open Access Journals (Sweden)

    Katharina Eder

    2015-03-01

    Full Text Available This article presents an innovative façade system designed to increase the thermal comfort inside an office room and to enhance the cooling capacity of the suspended cooling ceiling. A series of measurements is conducted in an existing office building with different façade systems (i.e., a combination of glazing and shading. An innovative façade system is developed based on this intensive set of measurements. The new system enhances the thermal comfort and cooling capacity of the suspended cooling ceiling. The main usage of the new system is the refurbishment and improvement of existing façade systems.

  16. Colour schemes and façade work at Drottningholm and Stockholm palaces Les couleurs des façades des palais royaux de Drottningholm et de Stockholm

    Directory of Open Access Journals (Sweden)

    Jan Lisinski

    2008-06-01

    Full Text Available Jan Lisinski présente les couleurs des façades des palais royaux de Drottningholm et de Stockholm. Les deux palais furent construits au xviie siècle mais firent l’objet de modifications par la suite. La présentation commence par un bref rappel historique centré sur les différentes couleurs utilisées pour les façades puis aborde la façon dont doivent être traitées les façades aujourd’hui. Il sera question en particulier du traitement des pierres, des plâtres, des maçonneries, des aciers et des cuivres... Les façades des deux palais sont actuellement en restauration mais les solutions mises en œuvre sont différentes. Au palais Royal de Stockholm, le plâtre est simplement nettoyé alors qu’au palais Drottningholm on refait les plâtres puis les peintures à la chaux.Jan Lisinski presents the colours of the façades of the royal palaces of Drottningholm and of Stockholm. The two palaces were constructed in the seventeenth century, but have undergone successive modifications. The presentation begins with a brief historical overview of the different colours used for the façades, then discusses the way the treatments are to be carried out. In particular, the treatment of stone, plaster, masonry, steel and copper will be examined. The façades of the two palaces are currently being restored, but the solutions for each are quite different. For the Royal Palace of Stockholm, the plaster is simply being cleaned, while at Drottningholm Palace, the plaster will be redone, then painted with lime paint.

  17. English training

    CERN Multimedia

    2003-01-01

    You have a good level of English BUT... You still need to improve your speaking or You have problems writing professional documents Would you like to work in a small group on either of these areas? Then, the following courses are for you! Writing Professional Documents in English The aim of the course is for students to improve their professional writing. Participants will work on technical, scientific or administrative documents depending on the needs of the group. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) Oral Expression The emphasis will be on oral expression with necessary feed-back. Speaking activities will include discussions, meeting simulations, role-plays etc. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow: tel. 72957 / Mrs. Tessa Osborne: Tessa.Osborne@cern.ch.

  18. English Training

    CERN Multimedia

    2003-01-01

    You have a good level of English BUT... You still need to improve your speaking or You have problems writing professional documents Would you like to work in a small group on either of these areas? Then, the following courses are for you! Writing Professional Documents in English The aim of the course is for students to improve their professional writing. Participants will work on technical, scientific or administrative documents depending on the needs of the group. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) Oral Expression The emphasis will be on oral expression with necessary feed-back. Speaking activities will include discussions, meeting simulations, role-plays etc. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow: tel. 72957 / Mrs. Tessa Osborne: Tessa.Osborne@cern.ch.

  19. English courses

    CERN Multimedia

    2013-01-01

    Cours d'anglais général et professionnel La prochaine session se déroulera du 4 mars jusqu’au 21 juin 2013. Ces cours s'adressent à toute personne travaillant au CERN ainsi qu'à leur conjoint. Pour le détail des cours proposés, consultez nos pages web. Oral Expression The next sessions will take place from 4 March to 21 June 2013. This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be on average of 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. More information here. Writing Professional Documents in English - Administrative Writing Professional Documents in English - Technical The next sessions will take place from 4 March to 21 June 2013. These courses are designed for people with a goo...

  20. English course

    CERN Multimedia

    HR Department

    2011-01-01

    General and Professional English Courses The next sessions will take place: From 3rd October 2011 to beginning of February 2012 (break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Kerstin Fuhrmeister, tel. 70896. Oral Expression The next sessions will take place from 3rd October 2011 to beginning of February 2012 (break at Christmas). This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be on average of 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Kerstin Fuhrmeister, tel. 70896. Writing Professional Documents in English - Administrative Wr...

  1. Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1/BRCA2

    Energy Technology Data Exchange (ETDEWEB)

    Godthelp, Barbara C. [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands); Buul, Paul P.W. van [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands); Jaspers, Nicolaas G.J. [Department of Cell Biology and Genetics, Erasmus University, P.O. Box 1738, 3000 DR Rotterdam (Netherlands); Elghalbzouri-Maghrani, Elhaam [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands); Duijn-Goedhart, Annemarie van [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands); Arwert, Fre [Department of Clinical Genetics and Human Genetics, Free University Medical Center, Amsterdam (Netherlands); Joenje, Hans [Department of Clinical Genetics and Human Genetics, Free University Medical Center, Amsterdam (Netherlands); Zdzienicka, Malgorzata Z. [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands) and Department of Molecular Cell Genetics, Collegium Medicum, N.Copernicus University, Bydgoszcz (Poland)]. E-mail: M.Z.Zdzienicka@LUMC.nl

    2006-10-10

    Fanconi anemia (FA) is an inherited cancer-susceptibility disorder, characterized by genomic instability and hypersensitivity to DNA cross-linking agents. The discovery of biallelic BRCA2 mutations in the FA-D1 complementation group allows for the first time to study the characteristics of primary BRCA2-deficient human cells. FANCD1/BRCA2-deficient fibroblasts appeared hypersensitive to mitomycin C (MMC), slightly sensitive to methyl methane sulfonate (MMS), and like cells derived from other FA complementation groups, not sensitive to X-ray irradiation. However, unlike other FA cells, FA-D1 cells were slightly sensitive to UV irradiation. Despite the observed lack of X-ray sensitivity in cell survival, significant radioresistant DNA synthesis (RDS) was observed in the BRCA2-deficient fibroblasts but also in the FANCA-deficient fibroblasts, suggesting an impaired S-phase checkpoint. FA-D1/BRCA2 cells displayed greatly enhanced levels of spontaneous as well as MMC-induced chromosomal aberrations (Canada), similar to cells deficient in homologous recombination (HR) and non-D1 FA cells. In contrast to Brca2-deficient rodent cells, FA-D1/BRCA2 cells showed normal sister chromatid exchange (SCE) levels, both spontaneous as well as after MMC treatment. Hence, these data indicate that human cells with biallelic BRCA2 mutations display typical features of both FA- and HR-deficient cells, which suggests that FANCD1/BRCA2 is part of the integrated FA/BRCA DNA damage response pathway but also controls other functions outside the FA pathway.

  2. Une forme urbaine du premier âge touristique: les promenades littorales

    Directory of Open Access Journals (Sweden)

    Franck DEBIÉ

    1993-03-01

    Full Text Available Les promenades maritimes caractérisent les stations de bord de mer du premier âge touristique (1850-1930. Elles traduisent dans le paysage un urbanisme spéculatif, à rapprocher de celui qui produit le square et le boulevard, et donnent lieu à une urbanisation du littoral sous forme de vastes appendices linéaires. Les pratiques sociales associées à la promenade rappellent celles du jardin de plaisir, et renvoient au même rêve d’une urbanité idéale, libérée des miasmes, des promiscuités sociales, des contraintes qui pèsent sur les amours et les jeux.

  3. FA-SAT Is an Old Satellite DNA Frozen in Several Bilateria Genomes

    Science.gov (United States)

    Chaves, Raquel; Ferreira, Daniela; Mendes-da-Silva, Ana; Meles, Susana; Adega, Filomena

    2017-01-01

    Abstract In recent years, a growing body of evidence has recognized the tandem repeat sequences, and specifically satellite DNA, as a functional class of sequences in the genomic “dark matter.” Using an original, complementary, and thus an eclectic experimental design, we show that the cat archetypal satellite DNA sequence, FA-SAT, is “frozen” conservatively in several Bilateria genomes. We found different genomic FA-SAT architectures, and the interspersion pattern was conserved. In Carnivora genomes, the FA-SAT-related sequences are also amplified, with the predominance of a specific FA-SAT variant, at the heterochromatic regions. We inspected the cat genome project to locate FA-SAT array flanking regions and revealed an intensive intermingling with transposable elements. Our results also show that FA-SAT-related sequences are transcribed and that the most abundant FA-SAT variant is not always the most transcribed. We thus conclude that the DNA sequences of FA-SAT and their transcripts are “frozen” in these genomes. Future work is needed to disclose any putative function that these sequences may play in these genomes.

  4. Anguished English

    CERN Document Server

    Lederer, Richard

    2006-01-01

    Anguished English is the impossibly funny anthology of accidental assaults upon our common language. From bloopers and blunders to Signs of the Times to Mixed-Up Metaphors . . . from Two-Headed Headlines to Mangling Modifiers . . . it's a collection that will leave you roaring with delight and laughter.Help wanteds:Wanted: Unmarried girls to pick fresh fruit and produce at night.Two-Headed Headlines:Grandmother of eight makes hole in one!Doctor testifies in horse suit.Modern-Day Malapropisms:I suffer from a deviant septum.

  5. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT - PHYSICAL REMOVAL OF MICROBIAL CONTAMINATION AGENTS IN DRINKING WATER, WATTS P{REMIER ULTRA 5 REVERSE OSMOSIS DRINKING WATER TREATMENT SYSTEM (POU)

    Science.gov (United States)

    The Watts Premier Ultra 5 system was tested for removal of bacteria and viruses at NSF International's Laboratory. Watts Premier submitted ten units, which were split into two groups of five. One group received 25 days of conditioning prior to challenge testing, while the secon...

  6. Qualitative Impact Assessment 2010: An Independent Study Conducted by BDRC Continental, Ltd., February-July 2010. Premier League Reading Stars

    Science.gov (United States)

    National Literacy Trust, 2010

    2010-01-01

    Premier League Reading Stars (PLRS) is in its eighth year. To complement a pre-post quantitative survey, an impact evidence base was required to inform consideration of continued funding into 2011 and beyond. PLRS is very highly regarded among child participants, parents, and librarians. The structure of the scheme, its basis on football, and the…

  7. [Sõltumatu Tantsu Ühenduse poolt korraldatud sarjast "Premiere"] / Evelin Lagle ; küsinud Tambet Kaugema

    Index Scriptorium Estoniae

    Lagle, Evelin, 1986-

    2012-01-01

    Uutele koreograafidele pühendatud sarja "Premiere" programmis osalevad tantsulavastustega neli tantsukunstnikku Eestist - Tallinna Ülikooli lõpetanud Svetlana Grigorjeva, Turu Kunstiakadeemia lõpetanud Kaisa Selde, Viljandi Kultuuriakadeemia lõpetanud Kristina-Maria Heinsalu ja Tallinna Ülikooli lõpetanud Christin Lunts

  8. ETV REPORT: REMOVAL OF CHEMICAL CONTAMINANTS IN DRINKING WATER – WATTS PREMIER INC. WP-4V DRINKING WATER TREATMENT SYSTEM

    Science.gov (United States)

    The Watts Premier WP-4V POU drinking water treatment system was tested for removal of aldicarb, benzene, cadmium, carbofuran, cesium, chloroform, dichlorvos, dicrotophos, fenamiphos, mercury, mevinphos, oxamyl, strontium, and strychnine. The WP-4V employs a reverse osmosis (RO) m...

  9. A narrative synthesis of the applicability of the CaR-FA-X model in child and adolescent populations: a systematic review.

    Science.gov (United States)

    Stewart, Tracy M; Hunter, Simon C; Rhodes, Sinéad M

    2017-10-01

    The CaR-FA-X model [Williams, J. M. G., Barnhofer, T., Crane, C., Hermans, D., Raes, F., Watkins, E., … Dalgleish, T. (2007). Autobiographical memory specificity and emotional disorder. Psychological Bulletin, 133(1), 122-148. doi: 10.1037/0033-2909.133.1.122 ] is the most prominent and comprehensive model of overgeneral autobiographical memory (OGM) and provides a framework for OGM. The model comprises of three mechanisms, capture and rumination, functional avoidance and impaired executive control. These can independently, or in interaction, account for OGM. This systematic review aims to evaluate the existing research on the CaR-FA-X model, and trauma exposure studies specific to child and adolescent populations. The following databases were searched: "PsychInfo", "PsychArticles", "PubMed", "Web of Science", "Medline", "SCOPUS" and "Embase" for English-language, peer-reviewed papers with samples OGM as well as for capture errors and OGM. Limited support was found for rumination, avoidance and impaired executive control in isolation. No support was found for interacting mechanisms and OGM. Partial support for the CaR-FA-X model was found for child and adolescent populations. Recommendations, proposals for future research and plausible explanations for the mixed findings are discussed.

  10. The Norwegian Façade Insulation Study: the efficacy of façade insulation in reducing noise annoyance due to road traffic.

    Science.gov (United States)

    Amundsen, Astrid H; Klæboe, Ronny; Aasvang, Gunn Marit

    2011-03-01

    The efficacy of façade insulation in providing an improved indoor noise environment and in reducing indoor noise annoyance was examined in a socio-acoustic before-and-after study with a control group. An average equivalent noise reduction inside the dwellings of 7 dB was obtained from the façade insulation. Whereas 42% of the respondents were highly annoyed in the before-situation, this dropped to 16% in the after study. The conclusion is therefore that the façade insulation provided a substantial improvement in the indoor noise environment. The advantage with respect to indoor noise annoyance, of having the bedroom facing the least noise-exposed side of the dwelling corresponded to a 6 dB noise reduction. The changes in annoyance from noise reduction due to the façade insulation were in accordance with what would be expected from the exposure-response curves obtained in the before-situation. A total of 637 respondents participated in the before-study. Of these, 415 also participated in the after study. Indoor and outdoor noise exposure calculations for each of the dwellings were undertaken before and after the façade insulation was implemented. © 2011 Acoustical Society of America

  11. Desalination of Walls and Façades

    Science.gov (United States)

    Wedekind, W.; Jáuregui Arreola, K.; Siegesmund, S.

    2012-04-01

    For large monumental objects like walls and façades, the common technique of applying poultices for desalination often are not effective. This practice is neither cost effective nor does it lead to the desired result of desalination. To manage the conservation and desalination of these kinds of objects, several sprinkling techniques are known and have been applied on historical objects. For example, in the wooden warship Vasa, which was excavated from the sea bottom in Stockholm/Sweden, a sprinkling method was applied in 1961 for conservation and desalination. A sprinkling method to desalinate porous mineral materials will be presented using three different case studies: the rock cut monument no. 825 in Petra/Jordan, the medieval monastary church of the former Franziscan convent in Zeitz/Germany and the baroque monastary church Santa Monica in Guadalajara/Mexico. Before to start with practical conservation, the material- and petropysical properties, focoussed on water transport properties, like porosity, pore size distribution, water uptake and drying rate were investigadet. Diagnostic investigations on the objects included the mapping of deterioration, moister content measurements and salt accumulation determined by borehole cuts samples at depth. In the sprinkling method water is sprayed onto the wall surface through nozzels arranged in a modular grid. Depending on the sprinkling duration, a small or a large amount of water seeps into the porous materials, whereby the depth penetration can be adjusted accordingly. The water not absorbed by the stone runs off the facade and can be collected in liter amounts and tested by electrical conductivity with respect to the dissolved substances. After the drying of the wall's surface and the accumulation of salt at the material's surface, the procedure is repeated. For each subsequent washing a lower content of salt should be brought to the surface. Step by step the salt concentration will eventually decrease to almost

  12. IDEOLOGY AND ENGLISH LANGUAGE TEACHING: RELATIONS AND IMPLICATIONS

    OpenAIRE

    Tainá Almeida Alves Martins; Diógenes Cândido de Lima

    2015-01-01

    Under the assertion that all discourse has political essence, being ideological by nature, in this paper we discuss concepts of ideology and its relation to English language (EL) teaching. For language is the mediator of ideologies, there is no way to see language teaching as a neutral exercise, rather as a politicized practice. In this article, the concept of ideology and its relationship to language and discourse are initially elucidated. For this, we make use of Bakhtin, Foucault and Fa...

  13. Measurement of FA and VitB12 in serum by TRFIA and its clinical application

    International Nuclear Information System (INIS)

    Zhou Jinhong; Wang Huimin

    2006-01-01

    To investigate the correlation between diseases and the quantity of folic acid(FA) and vitamine B 12 (VitB 12 ) in serum, the quantity of FA and VitB 12 in serum was measured by TR- FIA. The results showed that the levels of FA and VitB 12 in 68 controlled subjects were 20.13±5.72 nmol/L and 240.45±58.23 pmol/L respectively. The levels of FA and VitB 12 in 6 patients with megaloblastic anemia, 26 with medium-terminal gestation femineity, 7 with liver cirrhosis, 10 with gastric ulcerand 31 with cerebral infarction were significant lower than those in the control group. The level of FA in 24 with malignant hematopathy and 57 with malignant tumor was significantly lower but VitB 12 between the 31 patients with iron deficiency anemia and 12 with CAA and the control group. The amount of the FA in 9 patients with chronic atrophic gastritis and 42 blood donors were lower than that in the control. The determination of FA and VitB 12 levels may be quite significant in the diagnosis, therapy and prognosis of diseases. Laboratories should establish the reference values which fit the locals specifically. (authors)

  14. Fetal analysis with invasive method (FA-I) and fetal analysis with non-invasive method (FA-NI): replacing current, deceptively imprecise clinical nomenclature.

    Science.gov (United States)

    Chervenak, Frank A; McCullough, Laurence B; Dudenhausen, Joachim

    2017-11-27

    There is a problem with the current nomenclature of prenatal evaluation. The current nomenclature of "prenatal testing" and "prenatal screening" - along with their subsets of "ultrasound testing," "ultrasound screening," "non-invasive prenatal testing," "non-invasive prenatal screening," and "prenatal diagnosis" - has become so imprecise that clinical misinterpretation and distortion of the informed consent process are increasingly difficult to avoid. To remedy this problem, we propose a new, precise nomenclature: "fetal analysis with invasive method" (FA-I) and "fetal analysis with non-invasive method," (FANI) using various techniques. This new nomenclature is designed to be precise and therefore facilitate effective communication among physicians and with pregnant women. For ease of use the new nomenclature can be formulated as an abbreviation: FA-I and FA-NI.

  15. Efectos sobre el metabolismo lipoproteico y estrés oxidativo en ratas zucker fa/fa de cárnicos enriquecidos con glucomanano y espirulina

    OpenAIRE

    González Torres, Laura

    2016-01-01

    Esta memoria doctoral versa sobre los estudios que se realizaron para evaluar los efectos de reestructurados cárnicos (RP) enriquecidos con glucomanano y espirulina sobre crecimiento, tamaño y estructura de órganos, glucemia, insulinemia, resistencia a la insulina, metabolismo lipoproteico y estrés oxidativo en un modelo de síndrome metabólico como es la rata Zucker fa/fa. Para ello se diseñaron diferentes dietas hipersaturadas, añadidas o no con agente hipercolesterolemiante, conteniendo 15%...

  16. Technical Performance Analysis of Iran Premier League Soccer Players in 2012-2013 Season

    Directory of Open Access Journals (Sweden)

    Javani Mohsen

    2015-10-01

    Full Text Available Background and purpose of study : analysis of IRAN premier league soccer players’ technical performance in season 2012-2013, using a computerized match analysis system (Borhan Mobin Development Management Co, IRAN. Material and methods: in this study, data were obtained from 120 players, who performed in competitions 90 minutes. The players were classified into 3 positional roles: defenders, midfielders and forwards. Technical performance variables analysis included: total passes, total successful passes, pass accuracy, total shots; total shots to target, shot accuracy, ball interception and ball losses. The data were statistically analyzed by one-way ANOVA, Kruskal-Wallis, Mann-Whitney U and Tukey post hoc test. Results : The findings of this study showed that players performed about 45 passes per competition. Midfielders and defenders had significantly higher number of passes than forwards. Pass accuracy was about 67% and there were no significant differences between positional roles. Also, the players performed about 0.8 shots per competition, forwards and midfielders had significantly higher number of shots than defenders. Shot accuracy was about 31%; midfielders and forwards had significantly higher shot accuracy than defenders. Forwards showed significantly lower ball interception and higher ball losses than other positions. Conclusion : The result of this study showed that there were significant differences between some technical actions in positional roles. Therefore, coaches can use this information for individualization of training according to playing positions and for optimization of training in the amateur game.

  17. Evaluation of sports nutrition knowledge of New Zealand premier club rugby coaches.

    Science.gov (United States)

    Zinn, Caryn; Schofield, Grant; Wall, Clare

    2006-04-01

    Little is known about if and how team coaches disseminate nutrition information to athletes. In a census survey, New Zealand premier rugby coaches (n = 168) completed a psychometrically validated questionnaire, received by either Internet or standard mail (response rate, 46%), identifying their nutrition advice dissemination practices to players, their level of nutrition knowledge, and the factors determining this level of knowledge. The majority of coaches provided advice to their players (83.8%). Coaches responded correctly to 55.6% of all knowledge questions. An independent t-test showed coaches who imparted nutrition advice obtained a significantly greater score, 56.8%, than those not imparting advice, 48.4% (P = 0.008). One-way ANOVA showed significant relationships between total knowledge score of all coaches and qualifications [F(1,166) = 5.28, P = 0.001], own knowledge rating [F(3,164) = 6.88, P = 0.001] and nutrition training [F(1,166) = 9.83, P = 0.002]. We conclude that these rugby coaches were inadequately prepared to impart nutrition advice to athletes and could benefit from further nutrition training.

  18. Descriptive epidemiology of injuries in a Brazilian premier league soccer team

    Science.gov (United States)

    de Freitas Guina Fachina, Rafael Júlio; Andrade, Marília dos Santos; Silva, Fernando Roberto; Waszczuk-Junior, Silas; Montagner, Paulo César; Borin, João Paulo; de Lira, Claudio Andre Barbosa

    2013-01-01

    Soccer, which has a large number of participants, has a high injury incidence that causes both financial and time burdens. Therefore, knowledge about the epidemiology of soccer injuries could allow sports-medicine professionals, such as physicians and physiotherapists, to direct their work in specific preventive programs. Thus, our aim was to conduct an epidemiological survey of injuries sustained by professional soccer players from the same team who participated in the Brazilian championship premier league in 2009. To this end, we evaluated retrospectively player medical records from the team, which included name, date of birth, position, date of injury, mechanism of injury, and type of injury. In the period of study, 95 injuries were recorded: 42 (44.2%) were recorded during matches, and 53 (55.8%) during the training period. Injuries occurred more frequently in midfielders and strikers. All injuries happened in the lower limb, most of the injuries were muscular, and most occurred as the result of collisions with other athletes. In summary, this study demonstrates that there is a need for greater safety awareness in the training environment. PMID:24379722

  19. Incidence, Nature, and Pattern of Injuries to Referees in a Premier Football (Soccer) League

    Science.gov (United States)

    Kordi, Ramin; Chitsaz, Alireza; Rostami, Mohsen; Mostafavi, Reza; Ghadimi, Mahmoodreza

    2013-01-01

    Background: Despite the crucial role of referees in a soccer match, few researchers have targeted the injury profile of referees in their studies. Understanding the incidence, nature, and pattern of injuries could provide important information for educational and preventative efforts at the international level. Hypothesis: The incidence rate and patterns of acute injuries to official referees of the Iranian Premier Football League during the 2009-2010 season are similar to those reported among referees in short-term international competitions such as FIFA World Cup. Study Design: Prospective cohort study. Methods: Demographic data for 74 referees, including 30 main referees and 44 assistant referees, were collected at the beginning of the season. To record injuries and refereeing time, weekly contact was made by a physician. Results: In total, 102 injuries were reported by referees during the football season. The incidence rates of injuries among referees during training and matches were 4.6 and 19.6 injuries per 1000 hours, respectively. Muscular and tendon injuries were found to be the most common type of injury, and the most common site of injury was the lower leg followed by the hip and groin. Conclusion: The results of this study are consistent with similar prospective studies evaluating injuries to referees over the course of a short-term tournament. Clinical Relevance: These findings provide a base for suggesting possible preventive recommendations in future studies. PMID:24427414

  20. Effects of the Premier Hospital Quality Incentive Demonstration on Medicare patient mortality and cost.

    Science.gov (United States)

    Ryan, Andrew M

    2009-06-01

    To evaluate the effects of the Premier Inc. and Centers for Medicare and Medicaid Services Hospital Quality Incentive Demonstration (PHQID), a public quality reporting and pay-for-performance (P4P) program, on Medicare patient mortality, cost, and outlier classification. The 2000-2006 Medicare inpatient claims, Medicare denominator files, and Medicare Provider of Service files. Panel data econometric methods are applied to a retrospective cohort of 11,232,452 admissions from 6,713,928 patients with principal diagnoses of acute myocardial infarction (AMI), heart failure, pneumonia, or a coronary-artery bypass grafting (CABG) procedure from 3,570 acute care hospitals between 2000 and 2006. Three estimators are used to evaluate the effects of the PHQID on risk-adjusted (RA) mortality, cost, and outlier classification in the presence of unobserved selection, resulting from the PHQID being voluntary: fixed effects (FE), FE estimated in the subset of hospitals eligible for the PHQID, and difference-in-difference-in-differences. Data were obtained from CMS. Principal Findings. This analysis found no evidence that the PHQID had a significant effect on RA 30-day mortality or RA 60-day cost for AMI, heart failure, pneumonia, or CABG and weak evidence that the PHQID increased RA outlier classification for heart failure and pneumonia. By not reducing mortality or cost growth, this study suggests that the PHQID has made little impact on the value of inpatient care purchased by Medicare.

  1. Strategies for injury prevention in Brazilian football: Perceptions of physiotherapists and practices of premier league teams.

    Science.gov (United States)

    Meurer, Maurício Couto; Silva, Marcelo Faria; Baroni, Bruno Manfredini

    2017-11-01

    To describe the physiotherapists perceptions and the current practices for injury prevention in elite football (soccer) clubs in Brazil. Cross-sectional study. Group of Science in Sports & Exercise, Federal University of Healthy Sciences of Porto Alegre (Brazil). 16 of the 20 football clubs involved in the Brazilian premier league 2015. Physiotherapists answered a structured questionnaire. Most physiotherapists (∼88%) were active in design, testing and application of prevention programs. Previous injury, muscle imbalance, fatigue, hydration, fitness, diet, sleep/rest and age were considered "very important" or "important" injury risk factors by all respondents. The methods most commonly used to detect athletes' injury risk were: monitoring of biochemical markers (100% of teams), isokinetic dynamometry (81%), questionnaires (75%), functional movement screen (56%), fleximetry (56%) and horizontal jump tests (50%). All clubs used strength training, functional training, core exercises and balance/proprioception exercises in their injury prevention program; and Nordic hamstring exercise and other eccentric exercises were used by 94% of clubs. "FIFA 11+" prevention program was adapted by 88% of clubs. Physiotherapists perceptions and current practices of injury prevention within Brazilian elite football clubs were similar to those employed in developed countries. There remains a gap between clinical practice and scientific evidence in high performance football. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Design science research for decision support systems development: recent publication trends in the premier IS journals

    Directory of Open Access Journals (Sweden)

    Shah J Miah

    2016-11-01

    Full Text Available This paper presents a contemporary literature review of design science research (DSR studies in the domain of decision support systems (DSS development. The latest studies in the DSS design domain claim that DSR methodologies are the most popular design approach, but many details are still yet to be revealed for supporting this claim. In particular, it is important to thoroughly investigate the trends in either the form or deeper insights in use of DSR in this field. The aim of this study is to analyse the existing DSS design science studies to reveal insights into the use of DSR, so that we can outline research agenda for a special issue, based on findings of analysis. We selected articles (from 2005 to 2014 that were published in seven selected premier IS journals (ranked as A* in the ABDC journal ranking. The selected 57 sample articles are representative of DSS design studies that used DSR in theorising, designing, implementing, and evaluating DSS solutions. We discuss the theoretical positions of DSR for DSS development through six categories: DSS artefacts, DSR methods, DSR views, user involvement, DSS design innovations and problem domains. The findings indicate that new studies are needed to fill the knowledge gap in DSS design science, for more solid theoretical basis in near future.

  3. Trace elements in diamonds from the Premier, Finsch, and Jagersfontein mines, and their petrogenetic significance

    International Nuclear Information System (INIS)

    Fesq, H.W.; Bibby, D.M.; Erasmus, C.S.; Kable, E.J.D.

    1975-01-01

    Neutron-activation studies of the impurity chemistry of more than 1500 natural diamonds from three South African kimberlite sources, Premier, Finsch, and Jagersfontein, provide evidence for the presence of submicroscopic inclusions of a quenched (or temperature re-equilibrated) melt from which these diamonds crystallized. These microscopic inclusions of parental magma contain variable amounts of fluids rich in water and carbon dioxide, as well as iron-nickelcopper-cobalt sulphides, and a major silicate phase, which is remarkably constant in composition irrespective of the source of the diamonds and the age of emplacement of their host kimberlite. These microscopic inclusions are present in varying amounts in all the diamonds that were analysed, and may even dominate the impurity chemistry of diamonds having observable mineral inclusions. An estimate of the composition of the major elements in the silicate melt indicates that the diamonds that were investigated crystallized from picritic magma rich in water and carbon dioxide in the presence of immiscible iron-nickel-copper-cobalt sulphides [af

  4. Extinction (12) 1206 (FA) Extremum problem (9) 907 (SA) Fair game ...

    Indian Academy of Sciences (India)

    Admin

    ) 691 (GA). Discovery of Evershed effect (11) 1032 (GA). Donor-acceptor structure (1) 80 (FA). Downwash (2) 191 (SA). Drag (1) 32 (GA). Drypetes roxburghii (Wall.) Hurus (4) (FT). Ecdysones (10) 978 (GA). Edwin Powell Hubble (3) 211 (AIB).

  5. Arsenic exposure disrupts the normal function of the FA/BRCA repair pathway.

    Science.gov (United States)

    Peremartí, Jana; Ramos, Facundo; Marcos, Ricard; Hernández, Alba

    2014-11-01

    Chronic arsenic exposure is known to enhance the genotoxicity/carcinogenicity of other DNA-damaging agents by inhibiting DNA repair activities. Interference with nucleotide excision repair and base excision repair are well documented, but interactions with other DNA repair pathways are poorly explored so far. The Fanconi anemia FA/BRCA pathway is a DNA repair mechanism required for maintaining genomic stability and preventing cancer. Here, interactions between arsenic compounds and the FA/BRCA pathway were explored by using isogenic FANCD2(-/-) (FA/BRCA-deficient) and FANCD2(+/+) (FA/BRCA-corrected) human fibroblasts. To study whether arsenic disrupts the normal FA/BRCA function, FANCD2(+/+) cells were preexposed to subtoxic concentrations of the trivalent arsenic compounds methylarsonous acid (MMA(III)) and arsenic trioxide (ATO) for 2 weeks. The cellular response to mitomicin-C, hydroxyurea, or diepoxybutane, typical inducers of the studied pathway, was then evaluated and compared to that of FANCD2(-/-) cells. Our results show that preexposure to the trivalent arsenicals MMA(III) and ATO induces in corrected cells, a cellular FA/BRCA-deficient phenotype characterized by hypersensitivity, enhanced accumulation in the G2/M compartment and increased genomic instability--measured as micronuclei. Overall, our data demonstrate that environmentally relevant arsenic exposures disrupt the normal function of the FA/BRCA activity, supporting a novel source of arsenic co- and carcinogenic effects. This is the first study linking arsenic exposure with the FA/BRCA DNA repair pathway. © The Author 2014. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  6. Status of JSFR development in phase I FaCT project

    International Nuclear Information System (INIS)

    Aoto, Kazumi; Chikazawa, Yoshitaka; Kotake, Shoji; Ito, Takaya

    2011-01-01

    The Fast Reactor Cycle Technology Development (FaCT) project is pursuing commercialization of fast reactor cycle system around 2050 under cooperation of MEXT (Ministry of Education, Culture, Sports, Science and Technology), METI (Ministry of Economy, Trade and Industry), utilities, venders and JAEA (Japan Atomic Energy Agency). As results of the FaCT Phase I, the key technologies for Japan Sodium-cooled Fast Reactor (JSFR) has been evaluated. (author)

  7. A Conserved Metal Binding Motif in the Bacillus subtilis Competence Protein ComFA Enhances Transformation.

    Science.gov (United States)

    Chilton, Scott S; Falbel, Tanya G; Hromada, Susan; Burton, Briana M

    2017-08-01

    Genetic competence is a process in which cells are able to take up DNA from their environment, resulting in horizontal gene transfer, a major mechanism for generating diversity in bacteria. Many bacteria carry homologs of the central DNA uptake machinery that has been well characterized in Bacillus subtilis It has been postulated that the B. subtilis competence helicase ComFA belongs to the DEAD box family of helicases/translocases. Here, we made a series of mutants to analyze conserved amino acid motifs in several regions of B. subtilis ComFA. First, we confirmed that ComFA activity requires amino acid residues conserved among the DEAD box helicases, and second, we show that a zinc finger-like motif consisting of four cysteines is required for efficient transformation. Each cysteine in the motif is important, and mutation of at least two of the cysteines dramatically reduces transformation efficiency. Further, combining multiple cysteine mutations with the helicase mutations shows an additive phenotype. Our results suggest that the helicase and metal binding functions are two distinct activities important for ComFA function during transformation. IMPORTANCE ComFA is a highly conserved protein that has a role in DNA uptake during natural competence, a mechanism for horizontal gene transfer observed in many bacteria. Investigation of the details of the DNA uptake mechanism is important for understanding the ways in which bacteria gain new traits from their environment, such as drug resistance. To dissect the role of ComFA in the DNA uptake machinery, we introduced point mutations into several motifs in the protein sequence. We demonstrate that several amino acid motifs conserved among ComFA proteins are important for efficient transformation. This report is the first to demonstrate the functional requirement of an amino-terminal cysteine motif in ComFA. Copyright © 2017 American Society for Microbiology.

  8. English Course

    CERN Multimedia

    HR Department

    2012-01-01

    Cours d'anglais général et professionnel : La prochaine session se déroulera : du 27 février au 22 juin 2012. Ces cours s'adressent à toute personne travaillant au CERN ainsi qu'à leur conjoint. Pour vous inscrire et voir tout le détail des cours proposés, consultez nos pages Web: http://cern.ch/Training Vous pouvez aussi contacter Kerstin Fuhrmeister, tél. 70896. Oral Expression The next sessions will take place from 27 February to 22 June, 2012.  This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be on average of 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. For registration and further information on the courses, please consult our Web page: http://cern.ch/Training or contact Kerstin Fuhrmeister, tel. ...

  9. The strawberry FaMYB1 transcription factor suppresses anthocyanin and flavonol accumulation in transgenic tobacco.

    Science.gov (United States)

    Aharoni, A; De Vos, C H; Wein, M; Sun, Z; Greco, R; Kroon, A; Mol, J N; O'Connell, A P

    2001-11-01

    Fruit ripening is characterized by dramatic changes in gene expression, enzymatic activities and metabolism. Although the process of ripening has been studied extensively, we still lack valuable information on how the numerous metabolic pathways are regulated and co-ordinated. In this paper we describe the characterization of FaMYB1, a ripening regulated strawberry gene member of the MYB family of transcription factors. Flowers of transgenic tobacco lines overexpressing FaMYB1 showed a severe reduction in pigmentation. A reduction in the level of cyanidin 3-rutinoside (an anthocyanin) and of quercetin-glycosides (flavonols) was observed. Expression of late flavonoid biosynthesis genes and their enzyme activities were adversely affected by FaMYB1 overexpression. Two-hybrid assays in yeast showed that FaMYB1 could interact with other known anthocyanin regulators, but it does not act as a transcriptional activator. Interestingly, the C-terminus of FaMYB1 contains the motif pdLNL(D)/(E)Lxi(G)/S. This motif is contained in a region recently proposed to be involved in the repression of transcription by AtMYB4, an Arabidopsis MYB protein. Our results suggest that FaMYB1 may play a key role in regulating the biosynthesis of anthocyanins and flavonols in strawberry. It may act to repress transcription in order to balance the levels of anthocyanin pigments produced at the latter stages of strawberry fruit maturation, and/or to regulate metabolite levels in various branches of the flavonoid biosynthetic pathway.

  10. A BPMN-based process map for the design and construction of façades

    Directory of Open Access Journals (Sweden)

    Eleanor Voss

    2013-12-01

    Full Text Available Corresponding author: Eleanor Voss, Glass and Façade Technology Research Group, Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, UK. E-mail: ev236@cam.ac.uk Process mapping can lead to significant efficiency and quality improvements in construction engineering and is an ideal basis for developing IT support tools. The increasing complexity and multidisciplinary nature of façade design and construction suggest that a process map would be beneficial in this sector of the construction industry, but it has received limited attention to date. This paper presents a verified process map of the façade design and construction process. The map is the first of its kind to represent, in detail, the whole process relevant to all façade types, from commencement of the façade consultant's and contactor's participation, to the end of their involvement. The paper describes the process by which the mapping notation was selected, followed by the development and verification of the process map, including testing in two independent research projects. The BuildingSMART's BPMN notation is found to have superior system features and comprehensibility for this application and the resulting process map is easy to interpret and verify by industry experts. The trialling of the map in the two research projects indicate that the map is a useful tool for assessing process improvements in the façades sector.

  11. Energy performance of a ventilated façade by simulation with experimental validation

    International Nuclear Information System (INIS)

    Aparicio-Fernández, Carolina; Vivancos, José-Luis; Ferrer-Gisbert, Pablo; Royo-Pastor, Rafael

    2014-01-01

    A model for a building with ventilated façade was created using the software tool TRNSYS, version 17, and airflow parameters were simulated using TRNFlow. The results obtained with the model are compared and validated with experimental data. The temperature distribution along the air cavity was analysed and a chimney effect was observed, which produced the highest temperature gradient on the first floor. The heat flux of the external wall was analysed, and greater temperatures were observed on the external layer and inside the cavity. The model allows to calculate the energy demand of the building façade proposing and evaluating passive strategies. The corresponding office building for computer laboratories located in Valencia (Spain), was monitored for a year. The thermal behaviour of the floating external sheet was analysed using an electronic panel designed for the reading and storage of data. A feasibility study of the recovery of hot air inside the façade into the building was performed. The results obtained showed a lower heating demand when hot air is introduced inside the building, increasing the efficiency of heat recovery equipment. - Highlights: •An existing office building was monitored for a year. •A model of a ventilated façade by TRNSYS simulation tool was validated. •Air flow parameters inside the ventilated façade were identified. •Recovery of the hot air inside the façade for input into the building was studied

  12. Des Carnets aux « Éléments pour Le Premier Homme », et inversement...

    OpenAIRE

    Spiquel, Agnès

    2017-01-01

    Les Carnets de Camus sont un laboratoire de l’œuvre ; c’est vrai pour Le Premier Homme comme pour les œuvres précédentes. Il ne s’agira pas ici de voir comment les Carnets recueillent de nombreuses traces de la genèse du roman, mais de se demander si les Carnets fournissent un apport spécifique à ce roman autobiographique. À cet égard, on dispose désormais d’un document essentiel, « Éléments pour Le Premier Homme » dossier de travail qui accompagnait le manuscrit inachevé. Il n’avait pas été ...

  13. Far-red light photoacclimation (FaRLiP) in Synechococcus sp. PCC 7335: I. Regulation of FaRLiP gene expression.

    Science.gov (United States)

    Ho, Ming-Yang; Gan, Fei; Shen, Gaozhong; Zhao, Chi; Bryant, Donald A

    2017-02-01

    Far-red light photoacclimation (FaRLiP) is a mechanism that allows some cyanobacteria to utilize far-red light (FRL) for oxygenic photosynthesis. During FaRLiP, cyanobacteria remodel photosystem (PS) I, PS II, and phycobilisomes while synthesizing Chl d, Chl f, and far-red-absorbing phycobiliproteins, and these changes enable these organisms to use FRL for growth. In this study, a conjugation-based genetic system was developed for Synechococcus sp. PCC 7335. Three antibiotic cassettes were successfully used to generate knockout mutations in genes in Synechococcus sp. PCC 7335, which should allow up to three gene loci to be modified in one strain. This system was used to delete the rfpA, rfpB, and rfpC genes individually, and characterization of the mutants demonstrated that these genes control the expression of the FaRLiP gene cluster in Synechococcus sp. PCC 7335. The mutant strains exhibited some surprising differences from similar mutants in other FaRLiP strains. Notably, mutations in any of the three master transcription regulatory genes led to enhanced synthesis of phycocyanin and PS II. A time-course study showed that acclimation of the photosynthetic apparatus from that produced in white light to that produced in FRL occurs very slowly over a period 12-14 days in this strain and that it is associated with a substantial reduction (~34 %) in the chlorophyll a content of the cells. This study shows that there are differences in the detailed responses of cyanobacteria to growth in FRL in spite of the obvious similarities in the organization and regulation of the FaRLiP gene cluster.

  14. Pengaruh Kualitas Pelayanan, Harga Dan Lokasi Terhadap Loyalitas Melalui Kepuasan Tamu Pada Santika Premiere Dyandra Hotel & Convention Medan

    OpenAIRE

    Tambunan, Susi Marta

    2016-01-01

    Santika Premiere Dyandra Hotel & Convention, Medan, is one of movers in hotel service industry which combines products and services, including the combination of service quality, price, and location in order to attract and provide satisfaction for its guests. It also pays attention to and gives expectation and needs for the guests by giving something correctly which are in line with the guests’ need by providing good performance so that they will be satisfied and will eventually be loyal to t...

  15. Japanese Media in English.

    Science.gov (United States)

    Tanaka, Sachiko Oda

    1995-01-01

    Describes the use of English in the media in Japan, focusing on the role and history of English-language newspapers, radio, and television programs, as well as the proliferation of English-language films shown in Japanese cinemas. Discusses the implications of English in the Japanese media. (20 references) (MDM)

  16. The Ownership of English.

    Science.gov (United States)

    Widdowson, H. G.

    1994-01-01

    A plenary address from the 1993 Teachers of English to Speakers of Other Languages (TESOL) Convention discusses the question of how English teachers delimit and design their world. Issues of standard English are raised, and it is noted that, if English serves the communicative and communal needs of different communities, it must be diverse. (One…

  17. English as "Tyrannosaurus Rex."

    Science.gov (United States)

    Swales, John M.

    1997-01-01

    The increasing domination of English as the world's leading medium of international professional communication has begun to impact English for Academic Purposes (EAP) programs, specifically the question of whether English is becoming too successful. The article argues that resistance to the "triumphalism" of English is a responsibility of EAP…

  18. English Teaching Profile: Poland.

    Science.gov (United States)

    British Council, London (England). English Language and Literature Div.

    A review of the status of English language instruction in Poland begins with an overview of the role of English in the society in general, and outlines the status of English use and instruction in the educational system at all levels (elementary, secondary, higher, adult, and teacher), the characteristics and training of English language…

  19. On Observing World English.

    Science.gov (United States)

    Urdang, Lawrence

    1990-01-01

    Reviews the current state of World English. Subjects addressed include standard accents and dialects, prejudicial attitudes toward nonstandard "local" usages, the use of English as the language of diplomacy, American influences on the language, and the fracturing of English in non-English-speaking countries around the world. (17 references) (JL)

  20. Conversational English Program, 1.

    Science.gov (United States)

    Instituto de Idiomas Yazigi, Sao Paulo (Brazil). Centro de Linguistica Aplicada.

    This first book of a conversational English program for adults contains an introductory section in Portuguese and exercises in English. The text centers around an English-speaking family from the United States that goes to live in Brazil. It contains color photographs with captions followed by exercises. The exercises are in English and involve…

  1. Conversational English Program, 2.

    Science.gov (United States)

    Instituto de Idiomas Yazigi, Sao Paulo (Brazil). Centro de Linguistica Aplicada.

    This second book of a conversational English program for adults contains an introductory section in Portuguese and exercises in English. The text centers around an English-speaking family from the United States that goes to live in Brazil. It contains color photographs with captions followed by exercises. The exercises are in English and involve…

  2. Introducing Business English

    NARCIS (Netherlands)

    Nickerson, C.; Planken, B.C.

    2015-01-01

    Introducing Business English provides a comprehensive overview of this topic, situating the concepts of Business English and English for Specific Business Purposes within the wider field of English for Special Purposes. This book draws on contemporary teaching and research contexts to demonstrate

  3. Epidemiology and history of knee injury and its impact on activity limitation among football premier league professional referees

    Science.gov (United States)

    Mahdavi Mohtasham, Hamid; Shahrbanian, Shahnaz; Khoshroo, Fatemeh

    2018-01-01

    Abstract: Background: The purpose of this study was to determine the epidemiology and history of knee injury and its impact on activity limitation among football premier league professional referees in Iran. Methods: This was a descriptive study. 59 Football Premier League professional referees participated in the study. The knee injury related information such as injury history and mechanism was recorded. Injury related symptoms and their impacts on the activity limitation, ability to perform activities of daily living as well participation in sports and recreational activities was obtained through the Knee Outcome Survey (KOS). Results: The results indicated that 31 out of 59 participants reported the history of knee injury. In addition, 18.6%, 22.4% and 81% of the referees reported that they had been injured during the last 6 months of the last year, and at some point in their refereeing careers, respectively. Results further indicated that 48.8% of the injuries occurred in the non-dominant leg and they occurred more frequently during training sessions (52%). Furthermore, the value of KOS was 85 ± 13 for Activities of Daily Living subscale and 90 ± 9 for Sports and Recreational Activities subscale of the KOS. Conclusions: Knee injury was quite common among the Football Premier League professional referees. It was also indicated that the injuries occurred mainly due to insufficient physical fitness. Therefore, it is suggested that football referees undergo the proper warm-up program to avoid knee injury. PMID:29362295

  4. Philibert Delorme’s Divine Proportions and the Composition of the Premier Tome de l’Architecture

    Directory of Open Access Journals (Sweden)

    Sara Galletti

    2014-06-01

    Full Text Available In his 'Premier tome de l’architecture' (1567 — the first original, comprehensive architectural treatise written by a French author — Philibert Delorme (c. 1514–1570 claims to be the first to formulate a theory of divine proportions, which he describes as a set of rules recorded in the Old Testament as directly dictated by God to men for the construction of the Ark of Noah, the Ark of the Covenant, and the Temple and House of Solomon. Yet the author does not develop the theory of divine proportions in the 'Premier tome' and postpones it instead to the second volume of his treatise. As a second volume was never published (and likely never written, Delorme readers are left with a handful of less-than-coherent references and illustrations of a theory that remains largely obscure. Yet the elements of theory of divine proportions contained in the 'Premier tome' provide historians with an understanding of the genesis of the treatise itself, thus ultimately helping to raise broader questions about the book and its author. This paper shows how Delorme’s divine proportions offer a key to understanding the conception and composition of his treatise as well as to the process of intellectual development of the author and the changes in the nature and scope of his written work.

  5. General Secretary Jiang Zemin and Premier Li Peng on family planning.

    Science.gov (United States)

    Jiang, Z; Li, P

    1991-06-01

    Speeches given by General Secretary Jiang Zemin and Premier Li Peng to the forum on Family Planning (FP) Work in April 1991 are summarized. Jiang stated that the highest levels of communist party and governmental officials should be in charge of controlling population growth in China. There is great urgency to do so. The problems to be faced are a hugh population, scarce arable land, a poor economic foundation, and low per capita resources. Human resources are an asset for the socialist construction of China, but a rapid growth rate will retard economic and social development and affect the improvement in living standards and the quality of life. The strategy to place FP within state policy and place strict controls over population growth must be carried out resolutely. The future of socialism and the Chinese nation is at stake. Modernization cannot be accomplished with out controlling population growths. The 8th 5 year Plan and the 10 Year Program requirements will still contribute to 1.3 billion population by 2000 and 1.2 billion by 1995. There is historical responsibility, an urgency to strictly control population growth. Adherence to the 4 cardinal principles of socialism (the people's democratic dictatorship, the Communist Party leadership, and Marxist Leninist and Mao Zedong thought) must coexist with social development and family planning. All must be motivated. The provincial Party Secretary personally must oversee problems. The success or failure of FP should be used to evaluate the achievements of party committees and governments. The education on basic national conditions and the basic state policy on FP needs to be publicized through all organizations. There should be confidence in the masses. People must make FP their own cause voluntarily. Premier Li Peng stressed effective implementation and giving it high priority in order to achieve the 2nd step strategic goal of socialist modernization. Per capita output is low, and grain output will not increase

  6. PENGARUH PEMBAGIAN KERJA TERHADAP PENINGKATAN EFISIENSI KERJA KARYAWAN PASTRY DI HOTEL SANTIKA PREMIERE MALANG

    Directory of Open Access Journals (Sweden)

    Estikowati Estikowati

    2017-12-01

    Full Text Available The study was conducted to determine the effect of the division of labor on the work efficiency of pastry employees at Hotel Santika Premiere Malang. Work efficiency relates to the product produced with the resources used. While the division of labor is a separator type of work done by individuals. Researchers used the Simple Linear Regression Analyze method to predict how far the value of the dependent variable will be changed if the independent variable is changed. From result of research of independent variable (X that is Division of labor and dependent variable (Y Work efficiency have significant relation. This is evidenced from the data processing is known significant value sebersar 0.003 <0.05, with the conclusion Ho rejected and Ha accepted that there is influence between the Division of labor (X on Efficiency of work. From the questionnaire data the authors conclude that the existing division of labor is not appropriate for employees so that the level of efficiency of employees decreased. Normal 0 false false false IN X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-ansi-language:IN;} The study was conducted to determine the effect of the division of labor on the work efficiency of pastry employees at Hotel Santika Premiere Malang. Work efficiency relates to the product produced with the resources used. While the division of labor is

  7. Web English --the future?

    OpenAIRE

    Monaghan, A. I. C.

    1998-01-01

    Electronic communication, and particularly the World Wide Web, is becoming increasingly indispensable in our daily lives. The vast majority of the information currently exchanged electronically is in English, and it might be assumed that this will promote the use of English. Rarely is the contrary view presented, that the adoption of English as a general-purpose medium for global communication will change the English language and perhaps even lead to the creation of a «Web English» which repl...

  8. Effects of PREMIER lifestyle modifications on participants with and without the metabolic syndrome.

    Science.gov (United States)

    Lien, Lillian F; Brown, Ann J; Ard, Jamy D; Loria, Catherine; Erlinger, Thomas P; Feldstein, Adrianne C; Lin, Pao-Hwa; Champagne, Catherine M; King, Abby C; McGuire, Heather L; Stevens, Victor J; Brantley, Phillip J; Harsha, David W; McBurnie, Mary Ann; Appel, Lawrence J; Svetkey, Laura P

    2007-10-01

    Lifestyle modification can reduce blood pressure and lower cardiovascular risk. Established recommendations include weight loss, sodium reduction, and increased physical activity. PREMIER studied the effects of lifestyle interventions based on established recommendations alone and with the addition of the Dietary Approaches to Stop Hypertension (DASH) dietary pattern. This analysis aimed to assess the interventions' impact on cardiometabolic variables in participants with, compared with those without, metabolic syndrome. The primary outcome was 6-month change in systolic blood pressure. Participants with prehypertension or stage-1 hypertension were randomly assigned to an advice only control group, a 6-month intensive behavioral intervention group of established recommendations (EST), or an established recommendations plus DASH group (EST+DASH). Metabolic syndrome was defined per National Cholesterol and Education Program Adult Treatment Panel III. We used general linear models to test intervention effects on change in blood pressure, lipids, and insulin resistance (homeostasis model assessment), in subgroups defined by the presence or absence of metabolic syndrome. Of 796 participants, 399 had metabolic syndrome. Both EST and EST+DASH reduced the primary outcome variable, systolic blood pressure. Within the EST+DASH group, those with and without metabolic syndrome responded similarly (P=0.231). However, within EST, those with metabolic syndrome had a poorer response, with a decrease in systolic blood pressure of 8.4 mm Hg versus 12.0 mm Hg in those without metabolic syndrome (P=0.002). Thus, metabolic syndrome attenuated the systolic blood pressure reduction of EST, but this attenuation was overcome in EST+DASH. Finally, diastolic blood pressure, lipids, and homeostasis model assessment responded similarly to both interventions regardless of metabolic syndrome status. Our data suggest that strategies for lowering BP in individuals with metabolic syndrome may be

  9. Évaluation échographique des complications au premier trimestre de grossesse.

    Science.gov (United States)

    Morin, Lucie; Cargill, Yvonne M; Glanc, Phyllis

    2016-10-01

    RéSULTATS: SOURCES DE DONNéES: Nous avons effectué des recherches dans MEDLINE et un examen de la bibliographie des articles recensés. Le Comité d'imagerie diagnostique de la Société des obstétriciens et gynécologues du Canada a passé en revue les données probantes recueillies. Les recommandations reposent sur les lignes directrices élaborées par le Groupe d'étude canadien sur les soins de santé préventifs (tableau 1). AVANTAGES, DéSAVANTAGES ET COûTS: Les femmes qui présentent des saignements durant le premier trimestre peuvent recevoir un diagnostic incorrect d'avortement manqué. En outre, on risque de ne pas détecter une grossesse ectopique ou de les rassurer à tort sur la viabilité de l'embryon. L'amélioration de la détection des repères échographiques du développement embryonnaire normal et de la connaissance des facteurs de risque liés à l'échec de grossesse sur le plan échographique pourrait donner lieu à l'élaboration de stratégies de prise en charge mieux adaptées à chaque cas. Le diagnostic d'une grossesse ectopique suspectée repose souvent sur l'évaluation de marqueurs hormonaux et de caractéristiques échographiques. Par ailleurs, le diagnostic précoce de grossesse ectopique peut réduire la morbidité et la mortalité maternelles. RECOMMANDATIONS. Copyright © 2016 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada. Published by Elsevier Inc. All rights reserved.

  10. PREMIERS RESULTATS SUR LES COMPORTEMENTS DE SUBSISTANCE SOLUTREENS A LA GROTTE ROCHEFORT (MAYENNE, FRANCE

    Directory of Open Access Journals (Sweden)

    Céline Bemilli

    2013-09-01

    Full Text Available Le site de la grotte Rochefort (Mayenne, France a livré depuis 2005 plusieurs centaines de restes fauniques issus des couches Solutréennes. Le Renne et le Cheval en sont les principales composantes et reflètent le fond commun du régime alimentaire des Solutréens. Nous présenterons ici les premiers résultats de l’analyse archéozoologique concernant l’exploitation de ces deux principaux taxons. Plusieurs recollages ont été réalisés. L’exceptionnelle conservation des restes permet, outre une excellente lecture des traces de découpe, une première reconstitution des modalités d’acquisition et d’exploitation des animaux, ainsi que leur saison d’abattage. La rareté des ensembles fauniques solutréens fouillés et étudiés récemment donne à celui de la grotte Rochefort un impact particulier et inédit.Several hundreds faunal remains were discovered since 2005 in the Solutrean‘s level at Rochefort cave (Mayenne, France. Reindeer and Horse are the main taxa identified and are the baseline of the Solutrean diet. We present here the preliminary results of the faunal analysis and discuss the exploitation of these two main taxa. A number of refits were possible. At the same time, the exceptional preservation of the artefacts together with well-defined cut marks allows to reconstruct procurement and use patterns of these animals as well as the season they were killed. Recently excavated and analysed Solutrean faunal assemblages are rare which make the yet unreported Rochefort cave faunal assemblage even more important and unprecedented.

  11. Hospital arrival time and functional outcome after acute ischaemic stroke: results from the PREMIER study.

    Science.gov (United States)

    León-Jiménez, C; Ruiz-Sandoval, J L; Chiquete, E; Vega-Arroyo, M; Arauz, A; Murillo-Bonilla, L M; Ochoa-Guzmán, A; Carrillo-Loza, K; Ramos-Moreno, A; Barinagarrementeria, F; Cantú-Brito, C

    2014-05-01

    Information regarding hospital arrival times after acute ischaemic stroke (AIS) has mainly been gathered from countries with specialised stroke units. Little data from emerging nations is available. We aim to identify factors associated with achieving hospital arrival times of less than 1, 3, and 6 hours, and analyse how arrival times are related to functional outcomes after AIS. We analysed data from patients with AIS included in the PREMIER study (Primer Registro Mexicano de Isquemia Cerebral) which defined time from symptom onset to hospital arrival. The functional prognosis at 30 days and at 3, 6, and 12 months was evaluated using the modified Rankin Scale. Among 1096 patients with AIS, 61 (6%) arrived in <1 hour, 250 (23%) in <3 hours, and 464 (42%) in <6 hours. The factors associated with very early (<1 hour) arrival were family history of ischemic heart disease and personal history of migraines; in <3 hours: age 40-69 years, family history of hypertension, personal history of dyslipidaemia and ischaemic heart disease, and care in a private hospital; in <6 hours: migraine, previous stroke, ischaemic heart disease, care in a private hospital, and family history of hypertension. Delayed hospital arrival was associated with lacunar stroke and alcoholism. Only 2.4% of patients underwent thrombolysis. Regardless of whether or not thrombolysis was performed, arrival time in <3 hours was associated with lower mortality at 3 and 6 months, and with fewer in-hospital complications. A high percentage of patients had short hospital arrival times; however, less than 3% underwent thrombolysis. Although many factors were associated with early hospital arrival, it is a priority to identify in-hospital barriers to performing thrombolysis. Copyright © 2013 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

  12. Corporate social responsibility and mental health: the Premier League football Imagine Your Goals programme.

    Science.gov (United States)

    Henderson, Claire; O'Hara, Stefanie; Thornicroft, Graham; Webber, Martin

    2014-08-01

    Football is increasingly used to facilitate recovery in mental health services, often in partnership with football clubs. However, few clubs have made mental health part of their corporate social responsibility programmes until recently. We report the impact on participants of the 'Imagine Your Goals' programme, run by 16 Premier League football clubs in conjunction with England's Time to Change programme to reduce mental health-related stigma and discrimination. Mixed methods evaluation used pre/post measures of well-being, access to social capital, focus groups held early on and towards the end of the two-year programmes, and questionnaires for coaching staff. There were no significant changes to participants' mental well-being scores between baseline and follow-up, nor to the total number of social resources accessible through their networks. However, there was a statistically significant increase at follow-up in the mean score of the personal skills subscale of the Resource Generator-UK. Participants' individual skills were also higher at follow-up. Qualitative data showed programmes had largely met participants' expectations in terms of socializing, providing structure and improving fitness levels, exceeded expectations in relationships with coaching staff and additional activities, but did not always meet them in improving football skills. Participants varied in their knowledge of exit opportunities, depending on which club's programme they attended. A minority of clubs reported difficulties in recruitment and concerns about planning for the future of the projects. Football clubs and the charitable foundations they set up can successfully deliver programmes to people with mental health problems which improve access to personal skills social capital and have other potential benefits.

  13. Descriptive epidemiology of injuries in a Brazilian premier league soccer team

    Directory of Open Access Journals (Sweden)

    Fachina RJ

    2013-06-01

    Full Text Available Rafael Júlio de Freitas Guina Fachina,1,2 Marília dos Santos Andrade,3 Fernando Roberto Silva,4 Silas Waszczuk-Junior,4 Paulo César Montagner,1 João Paulo Borin,1 Claudio Andre Barbosa de Lira5 1Departamento de Ciência do Esporte, Faculdade de Educação Física, Universidade Estadual de Campinas (UNICAMP, Campinas, Brazil; 2Confederação Brasileira de Basketball (CBB, Rio de Janeiro, Brazil; 3Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, Brazil; 4Grêmio Barueri Futebol LTDA, Barueri, Brazil; 5Setor de Fisiologia Humana e do Exercício, Universidade Federal de Goiás, Câmpus Jataí, Jataí, Brazil Abstract: Soccer, which has a large number of participants, has a high injury incidence that causes both financial and time burdens. Therefore, knowledge about the epidemiology of soccer injuries could allow sports-medicine professionals, such as physicians and physiotherapists, to direct their work in specific preventive programs. Thus, our aim was to conduct an epidemiological survey of injuries sustained by professional soccer players from the same team who participated in the Brazilian championship premier league in 2009. To this end, we evaluated retrospectively player medical records from the team, which included name, date of birth, position, date of injury, mechanism of injury, and type of injury. In the period of study, 95 injuries were recorded: 42 (44.2% were recorded during matches, and 53 (55.8% during the training period. Injuries occurred more frequently in midfielders and strikers. All injuries happened in the lower limb, most of the injuries were muscular, and most occurred as the result of collisions with other athletes. In summary, this study demonstrates that there is a need for greater safety awareness in the training environment. Keywords: injuries, epidemiology, soccer players

  14. New methods for testing fire resistance of wood façade systems

    Directory of Open Access Journals (Sweden)

    Mårtensson August

    2016-01-01

    Full Text Available Arson in schools has been a huge problem in Sweden over the last fifteen years. The average amount of school arsons between 2000 and 2014 was 285 cases each year which corresponds to 50% of the total amount of reported fires in school buildings. This is a well-known problem and a lot of research has been done in this area. Investigations has been done about fire and heat detection systems, different technical factors significance in fire scenarios and how to prevent adolescents from starting fires. Another part of the problem that partly been investigated is how the schools are constructed. Roughly 50% of the arsons are outside of the school building. In Sweden one and two storey buildings are allowed to be built with wooden façades in accordance with the building code, which is one of the reasons many schools are built with wooden façade systems. The most critical part in a wood façade system from a fire safety perspective is concluded to be the eaves because of how they usually are built to let air pass through. Even though a wood façade isn't as well resistant to fire compared to a concrete façade, three versions of new test methods for combustible façades have been developed to make it possible to make sure in advance that a construction is resistant enough. The new test methods are focused on specific details and parts of a façade system to provide a more informative and useful result compared to SP Fire 105. Observations and measurements of flame spread and temperature changes in the eave, over the window joints and in the air gap are made. With these parameters in consideration criteria's has been chosen for a critical temperature of 280 ∘C at a critical time of 20 minutes.

  15. The cathepsin B inhibitor, z-FA-CMK is toxic and readily induced cell death in human T lymphocytes

    Energy Technology Data Exchange (ETDEWEB)

    Liow, K.Y.; Chow, S.C., E-mail: chow.sek.chuen@monash.edu

    2013-11-01

    The cathepsin B inhibitor, benzyloxycarbonyl-phenylalanine-alanine-chloromethylketone (z-FA-CMK) was found to be toxic and readily induced cell death in the human T cell line, Jurkat, whereas two other analogs benzyloxycarbonyl-phenylalanine-alanine-fluoromethylketone (z-FA-FMK) and benzyloxycarbonyl-phenylalanine-alanine-diazomethylketone (z-FA-DMK) were not toxic. The toxicity of z-FA-CMK requires not only the CMK group, but also the presence of alanine in the P1 position and the benzyloxycarbonyl group at the N-terminal. Dose–response studies showed that lower concentrations of z-FA-CMK induced apoptosis in Jurkat T cells whereas higher concentrations induced necrosis. In z-FA-CMK-induced apoptosis, both initiator caspases (-8 and -9) and effector caspases (-3, -6 and -7) were processed to their respective subunits in Jurkat T cells. However, only the pro-form of the initiator caspases were reduced in z-FA-CMK-induced necrosis and no respective subunits were apparent. The caspase inihibitor benzyloxycarbonyl-valine-alanine-aspartic acid-(O-methyl)-fluoromehylketone (z-VAD-FMK) inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentration of z-FA-CMK but has no effect on z-FA-CMK-induced necrosis and the loss of initiator caspases. This suggests that the loss of initiator caspases in Jurkat T cells during z-FA-CMK-induced necrosis is not a caspase-dependent process. Taken together, we have demonstrated that z-FA-CMK is toxic to Jurkat T cells and induces apoptosis at low concentrations, while at higher concentrations the cells die of necrosis. - Highlights: • z-FA-CMK is toxic and induce cell death in the human T cells. • z-FA-CMK toxicity requires the CMK group, alanine and the benzyloxycarbonyl group. • z-FA-CMK induced apoptosis at low concentration and necrosis at high concentration.

  16. The cathepsin B inhibitor, z-FA-CMK is toxic and readily induced cell death in human T lymphocytes

    International Nuclear Information System (INIS)

    Liow, K.Y.; Chow, S.C.

    2013-01-01

    The cathepsin B inhibitor, benzyloxycarbonyl-phenylalanine-alanine-chloromethylketone (z-FA-CMK) was found to be toxic and readily induced cell death in the human T cell line, Jurkat, whereas two other analogs benzyloxycarbonyl-phenylalanine-alanine-fluoromethylketone (z-FA-FMK) and benzyloxycarbonyl-phenylalanine-alanine-diazomethylketone (z-FA-DMK) were not toxic. The toxicity of z-FA-CMK requires not only the CMK group, but also the presence of alanine in the P1 position and the benzyloxycarbonyl group at the N-terminal. Dose–response studies showed that lower concentrations of z-FA-CMK induced apoptosis in Jurkat T cells whereas higher concentrations induced necrosis. In z-FA-CMK-induced apoptosis, both initiator caspases (-8 and -9) and effector caspases (-3, -6 and -7) were processed to their respective subunits in Jurkat T cells. However, only the pro-form of the initiator caspases were reduced in z-FA-CMK-induced necrosis and no respective subunits were apparent. The caspase inihibitor benzyloxycarbonyl-valine-alanine-aspartic acid-(O-methyl)-fluoromehylketone (z-VAD-FMK) inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentration of z-FA-CMK but has no effect on z-FA-CMK-induced necrosis and the loss of initiator caspases. This suggests that the loss of initiator caspases in Jurkat T cells during z-FA-CMK-induced necrosis is not a caspase-dependent process. Taken together, we have demonstrated that z-FA-CMK is toxic to Jurkat T cells and induces apoptosis at low concentrations, while at higher concentrations the cells die of necrosis. - Highlights: • z-FA-CMK is toxic and induce cell death in the human T cells. • z-FA-CMK toxicity requires the CMK group, alanine and the benzyloxycarbonyl group. • z-FA-CMK induced apoptosis at low concentration and necrosis at high concentration

  17. FA3100 series industrial personal computer, the highest speed model 7010 in Japan; Sangyoyo computer FA3100A series kokunai saisoku model 7010

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The FA3100 series industrial personal computer was added with the highest order model 7010 mounted with the Pentium(reg sing) III processor(550 MHz) which is of the highest speed in Japan. In association with the increase in information processing amount, applications requiring higher CPU processing speed are increasing also in the field of FA (Factory Automation). The model can respond to this demand. The number of expansion slot required for industrial use is eleven in total, providing affluent expandability. The three-series disk bay allowing devices to be mounted only by removing the front panel contains disks that can be selected according to their applications, such as the hard disk, duplicated hard disk, silicon disk, CD-ROM, and photo-magnetic (MO) disk. (translated by NEDO)

  18. The strawberry gene FaGAST affects plant growth through inhibition of cell elongation.

    Science.gov (United States)

    de la Fuente, José I; Amaya, Iraida; Castillejo, Cristina; Sánchez-Sevilla, José F; Quesada, Miguel A; Botella, Miguel A; Valpuesta, Victoriano

    2006-01-01

    The strawberry (Fragaria x ananassa) FaGAST gene encodes a small protein with 12 cysteine residues conserved in the C-terminal region similar to a group of proteins identified in other species with diverse assigned functions such as cell division, elongation, or elongation arrest. This gene is expressed in the fruit receptacle, with two peaks during ripening at the white and the red-ripe stages, both coincident with an arrest in the growth pattern. Expression is also high in the roots but confined to the cells at the end of the elongation zone. Exogenous application of gibberellin increased the transcript level of the FaGAST gene in strawberry fruits. Ectopic expression of FaGAST in transgenic Fragaria vesca under the control of the CaMV-35S promoter caused both delayed growth of the plant and fruits with reduced size. The same growth defect was observed in Arabidopsis thaliana plants overexpressing FaGAST. In addition, the transgenic plants exhibited late flowering and low sensitivity to exogenous gibberellin. Taken together, the expression pattern, the regulation by gibberellin, and the transgenic phenotypes point to a role for FaGAST in arresting cell elongation during strawberry fruit ripening.

  19. Typification for Façade Structures Based on User Perception

    Directory of Open Access Journals (Sweden)

    Jie Shen

    2016-12-01

    Full Text Available Typification is a well-established operator of map generalization. Although it is widely used in many existing research fields, less discussion has been devoted to the quality of typification. This paper presents a user survey for the evaluation of different typification results of façade structures under different constraints. The survey shows that preservation of the shape of the features is the most important constraint for a reasonable typification process, which has also been quantitatively verified by calculating the similarities between the typified façades and the original façade using attributed relational graph (ARG and nested earth mover’s distance (NEMD algorithms. Based on that, an algorithm is developed to generate perceivably reasonable representation from the original facade with decreasing map scale. The algorithm is implemented and tested on a number of façades. Experiments reveal that the typification can be automatically conducted and can create results which are well associated with the original façades.

  20. Application and properties of pure lime façades - case study

    Directory of Open Access Journals (Sweden)

    Violeta Bokan Bosiljkov

    2008-01-01

    Full Text Available The paper presents experiences obtained during application and testing of different pure lime façades that could be successfully used in restoration of historical buildings in Slovenia. The lime façade consists of a rendering layer (rough mortar, a finishing layer (fine mortar and a protective layer of lime wash. For the design of the mortars different industrially and traditionally produced limes were chosen, based on the results of preliminary studies of the authors and experiences of a small enterprise (SE involved in the study. The façade layers were applied to the most problematic northern wall of the historic chapel made from rubble masonry. The chapel belongs to the castle Crnelo, built at the end of the 17th century in the village Turnše, not far from Ljubljana, the capital of Slovenia. The façade layers were made by skilled workers of SE, with about one year time difference between application of rendering and finishing layers, and with a protective layer of coloured lime wash applied to one to three day old finishing layers. On the rendering layers, visual inspection, water absorption tests and determination of carbonation depth were carried out before subsequent finishing layers were applied. The same on-site tests were carried out also on finished façade layers. So far, parallel to the on-site tests, compressive and water absorption tests on prisms prepared from rough mortars were carried out in laboratory.

  1. Chao Fa Movies: The Transnational Production of Hmong American History and Identity by Ian G. Baird

    Directory of Open Access Journals (Sweden)

    Ian Baird

    2014-12-01

    Full Text Available Films made by and for particular social and ethnic peoples can reveal a great deal about identity issues. Here, I examine the cultural production, the content, and the socio-cultural and political significance of three Chao Fa-inspired Hmong films produced at Khek Noi, Thailand by Hmong American producers working with largely Hmong Thai actors. The first two, Chao Fa 1 and 2, were directed in 2009 by Kou Thao. The third, Vaj Tuam Thawj – The Legend of Chao Fa, was put together by Jimmy Vang, in 2010. Even though these Chao Fa films are fictional, they attempt to depict events and circumstances that are familiar to many first generation Hmong Americans, and they can muster strong emotions from people who see them as depicting factual history. In addition, just like many other American youth, many 1.5 generation Hmong are tied together by shared media experiences, including Hmong movies. Thus, the Chao Fa movies are important for producing and reproducing, reinforcing and dispersing ideas related to Hmong American identity and culture. They tell stories of the Hmong being oppressed by many different groups, and this history suggests why many Hmong—not only the Chao Fa—have long desired the type of independence and freedom from prejudice and discrimination that they imagine would come if the Hmong only had their own nation state.

  2. Research on Si (100) crystal substrate CMP based on FA/O alkaline slurry

    Science.gov (United States)

    Hong, Jiao; Niu, Xinhuan; Wang, Juan; Wang, Chenwei; Zhang, Baoguo; Wang, Ru; Sun, Ming; Liu, Yuling

    2017-10-01

    For the advanced IC technology nodes, the surface quality of the polished silicon substrate surface becomes more and more critical. Haze is used to characterize extremely small pits scatter light disproportionately at the angle of measurement (90°), and Haze collected on full wafer scale with high throughput is the key CMP output parameter in an advanced CMP process. In this study, the influence of surface defects especially scratch, particle contamination, and surface roughness on Haze was investigated. The results indicate scratch and particle contamination take some influence on Haze, and Haze increases quickly with the increasing of surface roughness. So it can be concluded that surface roughness is the key affecting factor of Haze. In addition, the influence of FA/O surfactant in the alkaline slurry on Haze was studied. The results show FA/O surfactant can effectively decrease Haze. Finally, the advantages of the FA/O alkaline slurry were exhibited by the contrast experiments. A much lower level of metallic ions residual and a much better WIWNU were gotten for silicon wafers polished by FA/O alkaline slurry than that by the commercial one. Hence, the FA/O alkaline slurry provides a high quality silicon wafer surface. The results are helpful for researching the silicon CMP as well as the other materials.

  3. Multi-angled façade system for office building renovation

    DEFF Research Database (Denmark)

    Hannoudi, Loay Akram; Christensen, Jørgen Erik; Lauring, Michael

    renovating office buildings. The architectural potential is presented with the help of AutoCAD software. The energy efficiency and indoor climate are investigated and evaluated by using correlational research and simulation research methods with the software IDA ICE. From a functional perspective, the multi......-angled façade increases the area of the office room and provides more space. There are many potential aesthetic benefits provided by multi-angled façades such as improved optical and visual quality from inside the office room and the possibility for daylight penetration and a view to outside from one part...... compared to a renovated flat façade varies between 4.9 and 6.5 kWh/(m2.year), depending on the orientation of the façade. The increase in the office room area, when renovated with a multi-angled façade, is by 19%, while the increase of the yearly primary energy consumption (not area weighted), is by 4...

  4. The effect of architectural façade design on energy savings in the student dormitory

    Directory of Open Access Journals (Sweden)

    Pejić Petar Č.

    2014-01-01

    Full Text Available There are many reasons for adequate use of natural light inside students' dormitories. Intensity of light required for student activities and temperature inside the rooms are the major factors for an occupant's comfortable work and life. Design of building façades has a significant impact both on the use of natural light and energy consumption. In this paper, a comparative analysis of student rooms with different orientations and different façade designs was performed in order to investigate what type of refurbishment in the façade is necessary. The goal of the refurbishment was generation of optimal thermal and lighting comfort for students' work with maximal energy saving for a new student dormitory in Nis, Serbia. An analysis of annual energy consumption of the newly designed student dormitory and proposed replacements on the exterior façade was performed by using the software EnergyPlus. Based on the energy consumption analysis it could be concluded that significant energy savings would be possible by upgrading the shading devices across the width of the window. In other words, changing the façade of the dorm could generally improve students' comfort, while the energy costs would be reduced. [Projekat Ministarstva nauke Republike Srbije, br. TR 36037: Development of student dorms in Serbia at the beginning of the 21st century i br. TR 33051: The concept of sustainable energy supply of settlements with energy efficient buildings

  5. FA-loaded lipid drug delivery systems: preparation, characterization and biological studies.

    Science.gov (United States)

    Carbone, Claudia; Campisi, Agata; Musumeci, Teresa; Raciti, Giuseppina; Bonfanti, Roberta; Puglisi, Giovanni

    2014-02-14

    The main purpose of this research was to prepare and to characterize ferulic acid-loaded nanostructured lipid carrier (FA-NLC) to evaluate the cytotoxic effect on human glioblastoma cancer U87MG cells. First of all, the influence of different materials on mean size and homogeneity of NLC prepared by a low energy organic solvent-free method was investigated. Technological characterization (encapsulation efficiency, mean particle size, homogeneity and in vitro release profile) was performed on the selected NLC in comparison to others lipid carriers, nanoemulsion and SLN. Furthermore, the thermal behavior of NLC and SLN was investigated using Differential Scanning Calorimetry (DSC) in order to evaluate their structure. Biological studies (MTT bioassay and caspase-3 cleavage) on the selected NLC showed no cytotoxic effects of the unloaded tested NLC. Besides, the effectiveness of FA-loaded NLC was higher compared to the free drug. Cells treated with FA or FA-loaded NLC showed a greater effect compared to idebenone (IDE) or IDE-loaded NLC, respectively. These results strongly support that FA-loaded NLC could be potentially used for the treatment of glioblastoma.

  6. Fitness costs and stability of Cry1Fa resistance in Brazilian populations of Spodoptera frugiperda.

    Science.gov (United States)

    Santos-Amaya, Oscar F; Tavares, Clébson S; Rodrigues, João Victor C; Campos, Silverio O; Guedes, Raul Narciso C; Alves, Analiza P; Pereira, Eliseu José G

    2017-01-01

    The presence of fitness costs of resistance to Bacillus thuringiensis (Bt) insecticidal proteins in insect populations may delay or even reverse the local selection of insect resistance to Bt transgenic crops, and deserves rigorous investigation. Here we assessed the fitness costs associated with Cry1Fa resistance in two strains of fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae), derived from field collections in different Brazilian regions and further selected in the laboratory for high levels of resistance to Cry1Fa using leaves of TC1507 corn. Fitness components were compared using paired resistant and susceptible strains with similar genetic backgrounds and F 1 generations from reciprocal crosses, all of them reared on non-transgenic corn leaves. No apparent life history costs in the larval stage were observed in the Bt-resistant strains. Moreover, the resistance remained stable for seven generations in the absence of selection, with no decrease in the proportion of resistant individuals. Larval respiration rates were also similar between resistant and susceptible homozygotes, and heterozygotes displayed respiration rates and demographic performance equal or superior to those of susceptible homozygotes. In combination, these results indicate the lack of strong fitness costs associated with resistance to Cry1Fa in the fall armyworm strains studied. These findings suggest that Cry1Fa resistance in S. frugiperda populations is unlikely to be counterselected in Cry1Fa-free environments. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  7. A BPMN-Based Process Map for the Design and Construction of Façades

    Directory of Open Access Journals (Sweden)

    Eleanor Voss

    2013-12-01

    Full Text Available Process mapping can lead to significant efficiency and quality improvements in construction engineering and is an ideal basis for developing IT support tools. The increasing complexity and multidisciplinary nature of façade design and construction suggest that a process map would be beneficial in this sector of the construction industry, but it has received limited attention to date. This paper presents a verified process map of the façade design and construction process.  The map is the first of its kind to represent, in detail, the whole process relevant to all façade types, from commencement of the façade consultant’s and contactor’s participation, to the end of their involvement. The paper describes the process by which the mapping notation was selected, followed by the development and verification of the process map, including testing in two independent research projects. The BuildingSMART’s BPMN notation is found to have superior system features and comprehensibility for this application and the resulting process map is easy to interpret and verify by industry experts. The trialling of the map in the two research projects indicate that the map is a useful tool for assessing process improvements in the façades sector.

  8. Physical interaction between the strawberry allergen Fra a 1 and an associated partner FaAP: Interaction of Fra a 1 proteins and FaAP.

    Science.gov (United States)

    Franz-Oberdorf, Katrin; Langer, Andreas; Strasser, Ralf; Isono, Erika; Ranftl, Quirin L; Wunschel, Christian; Schwab, Wilfried

    2017-10-01

    The strawberry fruit allergens Fra a 1.01E, Fra a 1.02 and Fra a 1.03 belong to the group of pathogenesis-related 10 (PR-10) proteins and are homologs of the major birch pollen Bet v 1 and apple allergen Mal d 1. Bet v 1 related proteins are the most extensively studied allergens but their physiological function in planta remains elusive. Since Mal d 1-Associated Protein has been previously identified as interaction partner of Mal d 1 we studied the binding of the orthologous Fra a 1-Associated Protein (FaAP) to Fra a 1.01E/1.02/1.03. As the C-terminal sequence of FaAP showed strong auto-activation activity in yeast 2-hybrid analysis a novel time resolved DNA-switching system was successfully applied. Fra a 1.01E, Fra a 1.02, and Fra a 1.03 bind to FaAP with K D of 4.5 ± 1.1, 15 ± 3, and 11 ± 2 nM, respectively. Fra a 1.01E forms a dimer, whereas Fra a 1.02 and Fra a 1.03 bind as monomer. The results imply that PR-10 proteins might be integrated into a protein-interaction network and FaAP binding appears to be essential for the physiological function of the Fra a 1 proteins. © 2017 Wiley Periodicals, Inc.

  9. Role of ComFA in controlling the DNA uptake rate during transformation of competent Bacillus subtilis.

    Science.gov (United States)

    Takeno, Masaomi; Taguchi, Hisataka; Akamatsu, Takashi

    2011-06-01

    The roles of ComFA and ComEC in DNA uptake by competent Bacillus subtilis were analyzed by transformation with DNA in protoplast lysates (LP transformation). Deletion mutants of comFA and comEC and putative Walker A mutants (K152N, K152Q, K152E) of comFA were constructed by fusion polymerase chain reaction. Transformants of comEC mutant with purified DNA and DNA in protoplast lysate were not obtained, which shows a lack of transformation ability and backwards recombination of the mutant. Transformants of the comFA mutant were obtained by LP transformation (1.8 × 10(4) transformants/μg DNA). Low relative efficiency of transformation (RET) of comFA compared to wild type (4.3 × 10(-4)) showed an important role for comFA in DNA uptake. Walker A mutants showed 1.8-19 × 10(-4) RET, suggesting a dependence on ATPase activity for transformation. Co-transformation between short linkages was only detected in comFA mutants. The results demonstrated that ComFA controlled the DNA uptake rate. The interpretation was further supported by analyzing the plasmid used in LP transformation of the comFA mutant. The RET of comFA compared to the wild type was 2.7 × 10(-2), 60-fold higher than that with chromosomal DNA (4.3 × 10(-4)). Following addition of DNA into comFA culture, transformants were obtained after 15 min, with the number of transformants increasing over time. The kinetics strongly suggested that in comFA mutants, formation of another DNA uptake complex without ComFA would be a lengthy process. Copyright © 2011 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  10. Modeling the binding of fulvic acid by goethite: the speciation of adsorbed FA molecules

    Science.gov (United States)

    Filius, Jeroen D.; Meeussen, Johannes C. L.; Lumsdon, David G.; Hiemstra, Tjisse; van Riemsdijk, Willem H.

    2003-04-01

    Under natural conditions, the adsorption of ions at the solid-water interface may be strongly influenced by the adsorption of organic matter. In this paper, we describe the adsorption of fulvic acid (FA) by metal(hydr)oxide surfaces with a heterogeneous surface complexation model, the ligand and charge distribution (LCD) model. The model is a self-consistent combination of the nonideal competitive adsorption (NICA) equation and the CD-MUSIC model. The LCD model can describe simultaneously the concentration, pH, and salt dependency of the adsorption with a minimum of only three adjustable parameters. Furthermore, the model predicts the coadsorption of protons accurately for an extended range of conditions. Surface speciation calculations show that almost all hydroxyl groups of the adsorbed FA molecules are involved in outer sphere complexation reactions. The carboxylic groups of the adsorbed FA molecule form inner and outer sphere complexes. Furthermore, part of the carboxylate groups remain noncoordinated and deprotonated.

  11. The new self-supporting face brick façades

    Directory of Open Access Journals (Sweden)

    C. del Río

    2016-12-01

    Full Text Available The ‘Self-Supporting’ face brick façade is the result of a profound reflection on the different façade solutions that have been used throughout the last century for the pillar-structured buildings, and is based on the utilization of the potential that ceramic materials have when they work in compression. The construction solution consists in placing the entire outer sheet of the enclosure ahead of the building’s structure, so as to use the brick wall itself as its own supporting structure. This construction type eliminates the thermal bridges at façade-slab joints, and is more effective regarding mechanical behaviour than conventional solutions, since the own-weight effect contributes beneficially to stability against horizontal actions.

  12. The influence of ventilated façade on sound insulation properties of envelope walls

    Directory of Open Access Journals (Sweden)

    Fišarová Zuzana

    2017-01-01

    Full Text Available Presented article deals with sound insulation properties of timber structures’ envelope walls. Particularly, the influence of heavy board ventilated façade on laboratory airborne sound insulation R and Rw in dB was studied. The installation method and gaps between façade boards can cause building defects originating in overrating the influence of ventilated cladding on envelope wall acoustic parameters. Real constructions were built for the experimental purposes and measurements, one with gaps between boards and one with simply eliminated gaps for mutual comparison. The results obtained were processed to make tables and graphs and to derive recommendations for the design of this type of constructions involving the general installation method of façade boards. Detailed results are depicted in conclusions.

  13. Altered Rhythms. Urban façades in post-war Milan

    Directory of Open Access Journals (Sweden)

    Magda Mària Serrano

    2017-10-01

    Full Text Available Urban façades are the outward manifestation of the character of a city, and are composed of elements that respond to rhythmic sequences in consonance with the internal order of the rooms behind them. In post-war Milan, façades were used as a field of experimentation by a group of architects, some of whom were also artists and designers, who saw themselves and can be seen as ambassadors for the future modernity of a city devastated by war. This article explains how the urban façades of Milan, based as they were on the themes drawn from the Italian compositional tradition, offer a wide variety of elements, figures and rhythms, altering and transgressing the compositional canons through the use of mechanisms that in some cases are closer to painting or sculpture than to architecture.

  14. DICTIONARIES LOOKUP STRATEGIES FOR ARABIC-ENGLISH TRANSLATION

    Directory of Open Access Journals (Sweden)

    Mohammad Ahmad THAWABTEH

    2013-05-01

    Full Text Available Bien que les dictionnaires ont une extrême importance dans les cours de traduction, on les considère comme une épée à double tranchant. De grotesques traductions indiquent clairement que les étudiants utilisent les dictionnaires d’une façon incompétente. Les données de cette étude représentent les traductions d’une vingtaine d’étudiants de premier cycle d’Anglais à l’université d’Al-quds et l’université de Palestine Ahlyia. Les traductions sont examinées à base des stratégies de recherche en dictionnaire. Les résultats de l’étude montrent que les pièges des sorties de la traduction que les étudiants font sont dus au: 1-la dépendance exagérée du dictionnaire. 2- le manque de compréhension du texte dans sa langue d’origine. 3- le fait de choisir le premier sens. 4- le peu d’attention accordée aux exemples illustrés dans le dictionnaire. 5- favoriser la lecture attentive sur la lecture superficielle. 6- ignorance totale des collocations, des idioms, et des proverbes. 7- l’incapacité de comprendre le sens du contexte. Quelques stratégies de recherche dans le dictionnaire qui peuvent aider les étudiants de traduction à effectuer leur travail rapidement et efficacement sont proposées.

  15. Multi-angled Façade System for Office Building Renovation

    DEFF Research Database (Denmark)

    Hannoudi, Loay Akram; Christensen, Jørgen Erik; Lauring, Michael

    renovating office buildings. The architectural potential is presented with the help of AutoCAD software. The energy efficiency and indoor climate are investigated and evaluated by using correlational research and simulation research methods with the software IDA ICE. From a functional perspective, the multi...... of the facade while i another part might be blocked by a shading device. From outside, the solutions may provide an interesting façade with a more dynamic form. Different scenarios are simulated and the results show that the saving in total primary energy consumption (area weighted) from a multi-angled façade...

  16. High Performance Building Façade Solutions-Phase II:

    OpenAIRE

    Lee, Eleanor S.; Coffey, Brian; Fernandes, Luis; Hoffman, Sabine; McNeil, Andrew; Thanachareonkit, Anothai; Ward, Gregory

    2014-01-01

    The High Performance Building Façade Solutions–Phase II project was initiated through the California Energy Commission’s Public Interest Energy Research (PIER) program in July 2010 to support industry’s development and deployment of both incremental and breakthrough façade technologies in partnership with the U.S. Department of Energy (DOE). The objective of this three-year project was to develop, or support the development and deployment of, promising near-term and emerging zero net energy b...

  17. FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression

    DEFF Research Database (Denmark)

    Tornehave, D; Jensen, Charlotte Harken; Teisner, B

    1996-01-01

    tumours. A negative correlation between FA1 and glucagon immunoreactants in these tumours prompted a reexamination of FA1 immunoreactants during fetal pancreatic development. At the earliest stages of development, FA1 was expressed by most of the non-endocrine parenchymal cells and, with ensuing......Fetal antigen 1 (FA1) is a glycoprotein containing six epidermal growth factor (EGF)-like repeats. It is closely similar to the protein translated from the human delta-like (dlk) cDNA and probably constitutes a proteolytically processed form of dlk. dlk is homologous to the Drosophila homeotic...... development, gradually disappeared from these cells and became restricted to insulin-producing beta cells. Throughout development FA1 was not detected in endocrine glucagon, somatostatin or pancreatic polypeptide cells. Moreover, developing insulin cells that coexpressed glucagon were negative for FA1. Thus...

  18. Teaching College English.

    Science.gov (United States)

    Ediger, Marlow

    College instructors of English need to use selected strands from the educational psychology arena in teaching so that students may achieve more optimally. Each student needs to experience a quality English curriculum. A quality English class emphasizes instructional procedures which are conducive to achieving, growing, and learning on the part of…

  19. English Teaching Profile: Brazil.

    Science.gov (United States)

    British Council, London (England). English Language and Literature Div.

    This review of the status of English language instruction in Brazil provides an overview of the Brazilian geographic, historical, and political context and the role of English in the society in general and in the educational system. The following topics are covered: an outline of the status of English use and instruction in the educational system…

  20. English in Vietnam.

    Science.gov (United States)

    Denham, P. A.

    1992-01-01

    The growing use of English in Vietnam is reviewed, along with the nation's linguistic history that exemplifies the close relationship between language and politics. The English curriculum in Vietnamese schools is described, and the future role of Outer Circle countries in English language teaching is considered. (19 references) (Author/LB)

  1. Moodling English Language Education

    Science.gov (United States)

    Coskun, Abdullah; Arslan, Abdullah

    2014-01-01

    This paper aims to emphasize the importance of using Moodle in foreign language learning and teaching by reviewing relevant literature and introducing a Moodle-based environment aiming to help English learners to practice their English by themselves. Firstly, the use of Moodle in education and more specifically in English Language Teaching is…

  2. English in Fiji.

    Science.gov (United States)

    Siegel, Jeff

    1989-01-01

    Traces the history of English in Fiji, especially in relation to education. The role of English in interethnic communication and as a language of wider communication with the outside world is discussed, and features of Fiji English, a local language variety, are described. (Author/CB)

  3. Noch Einmal:American English - British English (Once More: American English -- British English).

    Science.gov (United States)

    Botts, M.

    1980-01-01

    Replies critically to the article by D. K. Stevenson and R. J. Brunt, "Living English: Seeing the Forest in Spite of the Trees -- On Differences between American English and British English," in this journal, issue 1979/2. A reply by Stevenson and Brunt continues the controversy. (IFS/WGA)

  4. Sentential Negation in English

    Science.gov (United States)

    Mowarin, Macaulay

    2009-01-01

    This paper undertakes a detailed analysis of sentential negation in the English language with Chomsky's Government-Binding theory of Transformational Grammar as theoretical model. It distinguishes between constituent and sentential negation in English. The essay identifies the exact position of Negation phrase in an English clause structure. It…

  5. English Language Teaching in Indonesia.

    Science.gov (United States)

    Musthafa, Bachrudin

    2002-01-01

    Discusses the education system in Indonesia, the development of a national English syllabus, English in elementary and secondary schools and in higher education, private sector English courses, teacher preparation and professional development, and expatriate English teachers. (Author/VWL)

  6. The cathepsin B inhibitor z-FA-CMK induces cell death in leukemic T cells via oxidative stress.

    Science.gov (United States)

    Liow, K Y; Chow, Sek C

    2018-01-01

    The cathepsin B inhibitor benzyloxycarbonyl-phenylalanine-alanine-chloromethyl ketone (z-FA-CMK) was recently found to induce apoptosis at low concentrations in Jurkat T cells, while at higher concentrations, the cells die of necrosis. In the present study, we showed that z-FA-CMK readily depletes intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) generation. The toxicity of z-FA-CMK in Jurkat T cells was completely abrogated by N-acetylcysteine (NAC), suggesting that the toxicity mediated by z-FA-CMK is due to oxidative stress. We found that L-buthionine sulfoximine (BSO) which depletes intracellular GSH through the inhibition of GSH biosynthesis in Jurkat T cells did not promote ROS increase or induce cell death. However, NAC was still able to block z-FA-CMK toxicity in Jurkat T cells in the presence of BSO, indicating that the protective effect of NAC does not involve GSH biosynthesis. This is further corroborated by the protective effect of the non-metabolically active D-cysteine on z-FA-CMK toxicity. Furthermore, in BSO-treated cells, z-FA-CMK-induced ROS increased which remains unchanged, suggesting that the depletion of GSH and increase in ROS generation mediated by z-FA-CMK may be two separate events. Collectively, our results demonstrated that z-FA-CMK toxicity is mediated by oxidative stress through the increase in ROS generation.

  7. English Language Teaching Profile: Poland.

    Science.gov (United States)

    British Council, London (England). English-Teaching Information Centre.

    A profile of English language teaching in Poland is provided in outline form. The following topics are dealt with: the role of English in the country, teaching hours per week in English at each educational level, English language versus English literature, public examinations, syllabuses and textbooks, specialized English programs, adult English…

  8. Teacher of primary English

    CERN Multimedia

    2003-01-01

    Part-time teacher of primary English needed for September 2003 to teach English National Curriculum (KS2) and NLS to mother tongue or good second language English-speakers aged 7-10. 4 hours contact time per week, team planning, marking and meetings. Candidates should be English mother tongue qualified teachers, confident, flexible classroom practitioners and team players. For further details and how to apply see http://enpferney.org/staff_vacancies.htm English National Programme, Lycée International, Ferney-Voltaire (http://enpferney.org/)

  9. TEACHER OF ENGLISH NEEDED

    CERN Multimedia

    2002-01-01

    Part-time teacher of primary English needed for September 2002 to teach English National Curriculum (KS2) and NLS to mother tongue or good second language English-speakers aged 7-10. 4 hours contact time per week, team planning, marking and meetings. Candidates should be English mother tongue qualified teachers, confident, flexible classroom practitioners and team players. For further details and how to apply: engnat@hotmail.com or 04 50 40 82 66. Apply as soon as possible, and in any case before 8 July. English National Programme, Lycée International, Ferney-Voltaire.

  10. Genome Sequence of the Alkaline-Tolerant Cellulomonas sp. Strain FA1

    Science.gov (United States)

    Hu, Ping; Nguyen, My Vu; Kamennaya, Nina; Brown, Natasha; Woyke, Tanja; Kyrpides, Nikos; Holman, Hoi-Ying; Torok, Tamas

    2015-01-01

    We present the genome of the cellulose-degrading Cellulomonas sp. strain FA1 isolated from an actively serpentinizing highly alkaline spring. Knowledge of this genome will enable studies into the molecular basis of plant material degradation in alkaline environments and inform the development of lignocellulose bioprocessing procedures for biofuel production. PMID:26089422

  11. Foetal antigen 2 (FA2) in the stromal reaction induced by breast carcinoma

    DEFF Research Database (Denmark)

    Rasmussen, H B; Teisner, B; Andersen, J A

    1992-01-01

    An indirect immunoperoxidase technique was used to examine the distribution of foetal antigen 2 (FA2), a recently described basement membrane (BM)-associated antigen, in invasive breast carcinoma (n = 34), fibroadenoma (n = 5) and normal breast tissue (n = 5), and to compare its distribution...

  12. Automatic modelling of building façade objects via primitive shapes

    Science.gov (United States)

    Hetti Arachchige, N.; Perera, S.

    2014-08-01

    This paper presents a new approach to recognize individual façade objects and to reconstruct such objects in 3D using MLS point clouds. Core of the approach is a primitive shape based algorithm, which introduces building primitives, to identify the façade objects separately from other irrelevant objects and then to model the correct topology. The primitive shape is identified against defined different primitive shapes by using the Douglas-Peucker algorithm. The advantage of this process is that it offers an ability not only to model correct geometric shapes but also to remove occlusion effects from the final model. To evaluate the validity of the proposed approach, experiments have been conducted using two types of street scene point clouds captured by Optech Lynx Mobile Mapper System and Z+F laser scanner. Results of the experiments show that the completeness, correctness, and quality of the reconstructed building façade objects are well over 90 %, proving the proposed method is a promising solution for modelling 3D façade objects with different geometric shapes.

  13. HEAT TRANSFER EVALUATION OF HFC-236FA IN CONDENSATION AND EVAPORATION

    Science.gov (United States)

    The report gives results of an evaluation of the shell-side heat transfer performance of hydrofluorocarbon (HFC)-236fa, which is considered to be a potential substitute for chlorofluorocarbon (CFC)-114 in Navy shipboard chillers, for both conventional finned [1024- and 1575-fpm (...

  14. Modeling the binding of fulvic acid by goethite: The speciation of adsorbed FA molecules

    NARCIS (Netherlands)

    Filius, J.D.; Meeussen, J.C.L.; Hiemstra, T.; Riemsdijk, van W.H.

    2003-01-01

    Under natural conditions, the adsorption of ions at the solid-water interface may be strongly influenced by the adsorption of organic matter. In this paper, we describe the adsorption of fulvic acid (FA) by metal (hydr)oxide surfaces with a heterogeneous surface complexation model, the ligand and

  15. Adaptive Façade: Variant-Finding using Shape Grammar

    Science.gov (United States)

    Tomasowa, Riva; Utama Sjarifudin, Firza

    2017-12-01

    Modular façade construction has never been better since the birth of computer-aided manufacturing which bridges the modeling phase into the manufacturing phase for escalating the mass production. This comes to a result that the identity of a product or a building façade will commonly generate in the same way that the initial design was intended to. Rectifying the early model will then greatly impact the process later. The aim of this paper is to propose a way to solve these two challenges, without risking the manufacturing process, but more to explore the potential designs. Shape grammar is used to conceive more designs in the early stage, derived from the initial product – the modular adaptive façade system. The derivations are then tested through simulation to state the efficacy of the models. We find that the workflow somehow contributes to the better design and engineering process as well as the solution allows diversification in the façade expressions.

  16. FaSTR DNA: a new expert system for forensic DNA analysis.

    Science.gov (United States)

    Power, Timothy; McCabe, Brendan; Harbison, Sally Ann

    2008-06-01

    The automation of DNA profile analysis of reference and crime samples continues to gain pace driven in part by a realisation by the criminal justice system of the positive impact DNA technology can have in aiding in the solution of crime and the apprehension of suspects. Expert systems to automate the profile analysis component of the process are beginning to be developed. In this paper, we report the validation of a new expert system FaSTR DNA, an expert system suitable for the analysis of DNA profiles from single source reference samples and from crime samples. We compare the performance of FaSTR DNA with that of other equivalent systems, GeneMapper ID v3.2 (Applied Biosystems, Foster City, CA) and FSS-i(3) v4 (The Forensic Science Service((R)) DNA expert System Suite FSS-i(3), Forensic Science Service, Birmingham, UK) with GeneScan Analysis v3.7/Genotyper v3.7 software (Applied Biosystems, Foster City, CA, USA) with manual review. We have shown that FaSTR DNA provides an alternative solution to automating DNA profile analysis and is appropriate for implementation into forensic laboratories. The FaSTR DNA system was demonstrated to be comparable in performance to that of GeneMapper ID v3.2 and superior to that of FSS-i(3) v4 for the analysis of DNA profiles from crime samples.

  17. F-15A Versus F/A-22 Initial Operational Capability. A Case for Transformation

    National Research Council Canada - National Science Library

    Mott V, William H

    2005-01-01

    The F/A-22 Raptor is a new weapons system replacing- the F-15C Eagle. Its operational debut in 2005 comes at a time of constrained budgets, a changing global threat environment, and the ongoing global war on terrorism (GWOT...

  18. MISCIBILITY, SOLUBILITY, VISCOSITY, AND DENSITY MEASUREMENTS FOR R-236FA WITH POTENTIAL LUBRICANTS

    Science.gov (United States)

    The report gives results of miscibility, solubility, viscosity, and density measurements for refrigerant R-236fa and two potential lubricants . (The data are needed to determine the suitability of refrigerant/lubricant combinations for use in refrigeration systems.) The tested oi...

  19. Does Fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials?

    DEFF Research Database (Denmark)

    Floridon, C.; Jensen, C.H.; Thorsen, P.

    2000-01-01

    -embryonic tissues from normal and pathological pregnancies revealed FA1 in stromal cells surrounding the blood islands of the yolk sac as well as in placental fibroblasts where the expression was most pronounced in diploid, androgenic complete hydatidiform moles. However, as measured by ELISA, the circulating...

  20. The scope of inducing natural air supply via the façade

    NARCIS (Netherlands)

    van den Engel, P.J.W.; Kurvers, S.R.

    2017-01-01

    An overview is given of recent developments in the use of a system of inducing natural air supply via the façade in the Netherlands. This is followed by a review of the results of measurements from climate chamber experiments of its inducing ventilation performance and detailed insights gained

  1. Fetal antigen 1 (FA1), a circulating member of the epidermal growth factor (EGF) superfamily

    DEFF Research Database (Denmark)

    Jensen, Charlotte Harken; Krogh, T N; Støving, René Klinkby

    1997-01-01

    We describe an ELISA technique for quantification of fetal antigen 1 (FA1), a glycoprotein belonging to the EGF-superfamily. The ELISA is based on immunospecifically purified polyclonal antibodies and has a dynamic range of 0.7-5.3 ng/ml, intra- and inter-assay C.V.s of less than 3.2% and an aver...

  2. An Investigation of F/A-18 AMAD Gearbox Driveshaft Vibration

    Science.gov (United States)

    1997-11-01

    remained virtually constant relative to the angular position of the input PTS -348 shaft. This implied that the angular location of unbalance was...RAAF TFLM AMAD Vibration Data Base. June 1995. 10. Gatehouse , G., "F/A-18 AMAD Driveshaft Investigation". Ref GRG/BK/ MIL- ENG-0513 23 December 1994

  3. What is English?

    Directory of Open Access Journals (Sweden)

    Ulrikke Rindal

    2014-10-01

    Full Text Available This article considers the developing status of English in Norway, both as a language and as a school subject, making predictions about which ontological and epistemological perspectives will influence English language teaching (ELT in Norway towards 2030. Status quo and predictions for English in Norway is approached from two angles; the development of presiding language beliefs in linguistic science and in ELT practices from the 16th century to the present, and the more recent and rapid development of English as the foremost global language of communication. The article shows how English language beliefs and the status of English are made visible in the national subject curriculum and in the English language practices among Norwegian adolescent learners. The discussion suggests that English is increasingly characterised by those who use it as a second or later language, including Norwegians who negotiate the meanings of English in the ELT classroom. The article predicts that a logical development for Norwegian ELT is increased influence from social constructionist perspectives, in combination with the existing focus on communicative competence. The study shows that global circumstances related to the status of English are reciprocally related to local language beliefs among educational authorities, teachers and students, and that these have major implications for English as a discipline in lower and higher education.

  4. The yeast genus Tortispora gen. nov., description of Tortispora ganteri sp. nov., Tortispora mauiana f.a., sp. nov., Tortispora agaves f.a., sp. nov., Tortispora sangerardonensis f.a., sp. nov., Tortispora cuajiniquilana f.a., sp. nov., Tortispora starmeri f.a., sp. nov. and Tortispora phaffii f.a., sp. nov., reassignment of Candida caseinolytica to Tortispora caseinolytica f.a., comb. nov., emendation of Botryozyma, and assignment of Botryozyma, Tortispora gen. nov. and Trigonopsis to the family Trigonopsidaceae fam. nov.

    Science.gov (United States)

    Lachance, M-A; Kurtzman, C P

    2013-08-01

    We describe the yeast genus Tortispora gen. nov., an early-diverging lineage in the Saccharomycetales that displays the formation of helical ascospores. The genus is based on 16 strains resembling Candida caseinolytica that were isolated from necrotic plant tissue in warm regions of the New World. Based on sequences of the D1/D2 domains of the nuclear large subunit rRNA gene, as well as other data, the strains are assigned to eight distinct species. The species are nutritionally specialized and share the unusual ability to hydrolyse casein and to grow on 1-butanol as sole carbon source. One species of the proposed new genus produces a simple ascus with a helical ascospore, whereas other species of the clade have failed to form ascospores. All species in the clade, including C. caseinolytica, are assigned to Tortispora gen. nov. The new binomials are Tortispora ganteri sp. nov., type species of the genus (SUB 86-469.5(T) = CBS 12581(T) = NRRL Y-17035(T)), Tortispora caseinolytica f.a., comb. nov. (UCD-FST 83-438.3(T) = CBS 7781(T) = NRRL Y-17796(T)), Tortispora mauiana f.a., sp. nov. (UWOPS 87-2430.3(T) = CBS 12803(T) = NRRL Y-48832(T)), Tortispora agaves f.a., sp. nov. (UWOPS 94-257.6(T) = CBS 12794(T) = NRRL Y-63662(T)), Tortispora sangerardonensis f.a., sp. nov. (UWOPS 00-157.1(T) = CBS 12795(T) = NRRL Y-63663(T)), Tortispora cuajiniquilana f.a., sp. nov. (UWOPS 99-344.4(T) = CBS 12796(T) = NRRL Y-63664(T)), Tortispora starmeri f.a., sp. nov. (G 91-702.5(T) = CBS 12793(T) = NRRL Y-63665(T)) and Tortispora phaffii f.a., sp. nov. (UWOPS 91-445.1(T) = CBS 12804(T) = NRRL Y-48833(T)). In addition, species formerly assigned to the genus Ascobotryozyma are reassigned to the genus Botryozyma. The genera Trigonopsis, Botryozyma and Tortispora are assigned to the family Trigonopsidaceae fam. nov.

  5. Protein source in a high-protein diet modulates reductions in insulin resistance and hepatic steatosis in fa/fa Zucker rats.

    Science.gov (United States)

    Wojcik, Jennifer L; Devassy, Jessay G; Wu, Yinghong; Zahradka, Peter; Taylor, Carla G; Aukema, Harold M

    2016-01-01

    High-protein diets are being promoted to reduce insulin resistance and hepatic steatosis in metabolic syndrome. Therefore, the effect of protein source in high-protein diets on reducing insulin resistance and hepatic steatosis was examined. Fa/fa Zucker rats were provided normal-protein (15% of energy) casein, high-protein (35% of energy) casein, high-protein soy, or high-protein mixed diets with animal and plant proteins. The high-protein mixed diet reduced area under the curve for insulin during glucose tolerance testing, fasting serum insulin and free fatty acid concentrations, homeostatic model assessment index, insulin to glucose ratio, and pancreatic islet cell area. The high-protein mixed and the high-protein soy diets reduced hepatic lipid concentrations, liver to body weight ratio, and hepatic steatosis rating. These improvements were observed despite no differences in body weight, feed intake, or adiposity among high-protein diet groups. The high-protein casein diet had minimal benefits. A high-protein mixed diet was the most effective for modulating reductions in insulin resistance and hepatic steatosis independent of weight loss, indicating that the source of protein within a high-protein diet is critical for the management of these metabolic syndrome parameters. © 2015 The Obesity Society.

  6. Neurons in the monoaminergic nuclei of the rat and human central nervous system express FA1/dlk

    DEFF Research Database (Denmark)

    Jensen, Charlotte Harken; Meyer, M; Schrøder, Henrik Daa

    2001-01-01

    /autocrine manners, both forms have been shown to be active in the differentiation/proliferation process of various cell types. In adults, FA1/dlk has been demonstrated mainly within (neuro) endocrine tissues. In this study we investigated the presence of FA1/dlk in other parts of the developing and adult rat...

  7. Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation

    International Nuclear Information System (INIS)

    Petersen, Cordula; Zips, Daniel; Krause, Mechthild; Schoene, Kerstin; Eicheler, Wolfgang; Hoinkis, Cordelia; Thames, Howard D.; Baumann, Michael

    2001-01-01

    Purpose: FaDu human squamous cell carcinoma (FaDu-hSCC) showed a clear-cut time factor during fractionated radiotherapy (RT) under ambient blood flow. It remained unclear whether this is caused solely by proliferation or if radioresistance resulting from increasing hypoxia contributed to this phenomenon. To address this question, repopulation of clonogenic FaDu cells during fractionated RT under clamp hypoxia was determined by local tumor control assays, and compared to the results after irradiation with the same regimen under ambient blood flow. Methods and Materials: FaDu-hSCC was transplanted into the right hind leg of NMRI nu/nu mice. In the first set of experiments, irradiation was performed under clamp hypoxia. After increasing numbers of 3 Gy fractions (time intervals 24 h or 48 h), graded top-up doses were given to determine the TCD 50 (dose required to control 50% of the tumors). In the second set of experiments, all 3 Gy fractions were applied under ambient conditions, but as in the previous experiments the graded top-up doses were given under clamp hypoxia. A total of 26 TCD 50 assays were performed and analyzed using maximum likelihood techniques. Results: With increasing numbers of daily fractions, the top-up TCD 50 under clamp hypoxia decreased from 39.4 Gy [95% CI 36, 42] after single dose to 19.8 Gy [15, 24] after 18 fractions in 18 days and to 37.8 Gy [31, 44] after 18 fractions in 36 days. The results were consistent with biphasic repopulation, with a switch to rapid repopulation after about 22 days [13, 30]. The clonogen doubling time (T clon ) decreased from 9.8 days [0, 21] in the beginning of RT to 3.4 days after 22 days. Under ambient blood flow the top-up TCD 50 decreased from 37.6 Gy [34, 40] after single dose irradiation to 0 Gy [0, 1] after 18 fractions in 18 days and 22.4 Gy [18, 27] after 18 fractions in 36 days. Similar to results from irradiations under clamp hypoxia, the ambient data were consistent with a biphasic course of clonogen

  8. Trace element chemistry of peridotitic garnets in diamonds from the Premier (Cullinan) and Finsch kimberlites, South Africa: Contrasting styles of mantle metasomatism

    Science.gov (United States)

    Viljoen, K. S.; Harris, J. W.; Ivanic, T.; Richardson, S. H.; Gray, K.

    2014-11-01

    The purpose of this paper is to provide, discuss, and interpret a comprehensive set of geochemical data (involving major elements as well as Ni, Ti, Sr, Y, Zr, Nb, Hf and the rare earth elements) for peridotitic garnets in diamonds from Premier and Finsch, with a view on the nature of the metasomatic processes operating up to the time of diamond crystallisation, and the location of these two diamondiferous kimberlites within and outside the region of low seismic velocity in the Kaapvaal lithosphere. Trace element data were acquired using an ion microprobe, and a new method for the analysis of Ni in garnet by ion microprobe is presented. Peridotitic garnets in diamonds from the Premier mine are characterised by a significantly higher proportion of the lherzolite paragenesis relative to diamonds from other South African mines, such as Finsch, Venetia and De Beers Pool. Based on Ni-in-garnet thermometry, inclusion encapsulation temperatures of 1055 °C to 1669 °C are calculated for peridotitic garnets from Premier, with an average temperature of 1215 °C. Calculated temperatures for garnets from Finsch range from 1036 °C to 1167 °C, and are generally lower than for Premier, with an average of 1098 °C. The garnets in the diamonds from Premier and Finsch reflect contrasting styles of metasomatism associated with diamond crystallisation, with a low temperature fluid-type metasomatism prevalent in the case of the Paleoarchean diamonds from Finsch, and a higher temperature melt-related metasomatism occurring in the case of the Paleoproterozoic diamonds from Premier. The metasomatic agent accompanying diamond crystallisation at Finsch is effective at introducing Sr, the light rare earth elements, and some Zr into the lithosphere, but is ineffective at transporting much Ca, Ti, Y and heavy rare earth elements. In the case of Premier the metasomatic agent is highly effective at element transport, introducing e.g. Ca, Fe, Ti, Zr, Y and the rare earth elements. The location

  9. [Pierre Chirac "premier physician" of the king and the aborted plan to create an "Académie de médecine" in Paris (1731-1732)].

    Science.gov (United States)

    Lunel, Alexandre

    2005-03-01

    After being appointed "premier physician" in 1731, Pierre Chirac, thanks to his influence with the king, tried to realize an ambitious project. Inspired by the creation of an Academie de Chirurgie by the "premier surgeon", Chirac decided to creation an Académie de Médecine in Paris. Under his guidance, it was planned to collect opinions from all doctors of the kingdom in order to enhance global knowledge of disease, symptoms and treatments. However, threatened with the loss of its secular superiority, the Paris University Medical School immediately opposed the project. Although well advanced, the project was finally abandoned on Chirac's death.

  10. Thermal performance of vertical greening system on the building façade: A review

    Science.gov (United States)

    Sari, Astri Anindya

    2017-09-01

    Over the last decade, research on the application of vertical greening system on the building façade has gained much attention. Those studies proved that installing a vertical greening system on the building facade has many advantages not only for the building but also for the city. Acting as a shading as well as thermal insulation in the building, reducing greenhouse gas emission, and improving the microclimate are some of the advantages of vertical greening system that already being proved. This study aims to review some studies related to the thermal performance of vertical greening system on the building façade. The review will provide comprehensive knowledge about the thermal performance of vertical greening system over different variations including climates, orientations, plant types, and the design of vertical greening system. Furthermore, this review is expected to be a reference in designing such vertical greening system which suitable for certain climate area that able to produce the best thermal performance.

  11. Efficient Thermal Insulation of Passive House with Curved Façades in Cold Climate

    Directory of Open Access Journals (Sweden)

    Aznabaev Askar

    2016-01-01

    Full Text Available In this paper there is exploration of the possibility of creating effective sealed building envelope in zero energy building (ZEB with unique façades. This article describes passive and active measures of decrease of thermal loss through enclosure structures, usage of modern insulation materials; positive effect of rationalization of the façade orientation and form of a building in a plan; on the base of existing architecture concept structural solutions of building envelope are suggested. Using thermal FEA the enclosure structure was optimized. The results of modeling of units and elements of building envelope are: heat transfer coefficient U-value for heterogeneous multilayer structure, picture of temperature distribution and magnitude of the thermal conductivity and temperature of internal wall surface.

  12. L’abbaye de Cluny III : étude de la façade gothique

    Directory of Open Access Journals (Sweden)

    Juliette Rollier-Hanselmann

    2011-09-01

    Full Text Available Si l’histoire du déclin de Cluny a été étudiée par les historiens, l’évolution de la sculpture gothique n’a pas encore suscité de véritables recherches. La documentation témoigne d’une façade monumentale, ornée de plusieurs sculptures figuratives et d’une grande rose, dont il ne reste malheureusement que quelques dizaines de fragments. Une première analyse archéologique des élévations a été réalisée, ainsi qu’une étude des fragments issus de la façade, de manière à orienter les travaux de res...

  13. Aggressive Recurrence of Oral Squamous Cell Carcinoma in a patient with Fanconi’s Anaemia (FA)

    LENUS (Irish Health Repository)

    Nolan, M.

    2017-03-01

    Fanconi’s Anaemia is a rare autosomal recessive disease for which the incidence of head and neck cancer can be increased 700-fold1. We report a case of a 31-year old Caucasian male with FA who initially presented in July 2007 with oral squamous cell carcinoma for which he received radical surgery and radiotherapy. He was disease-free until August 2015 when he presented with an extremely aggressive recurrence.

  14. Concept and development status of fast breeder reactor fuels in the FaCT project

    International Nuclear Information System (INIS)

    Maeda, S.; Suzuki, M.; Kaito, T.; Tanaka, K.; Abe, T.

    2013-01-01

    The fuel development and the conceptual design study have been progressed in the first phase of the FaCT project in Japan. Significant outcomes of key technologies related to fuel design, fuel properties, core materials, fuel fabrication have been provided. The prospects of these technologies have been identified. After the Fukushima accident, the research and development for reducing the amount and toxic level of radioactive wastes will be promoted more than before. These outcomes will be reflected on the future development

  15. Bilingual Education and English Proficiency

    Science.gov (United States)

    Jepsen, Christopher

    2010-01-01

    In 2001, California instituted a statewide test measuring English proficiency for English learners, students who are not proficient in English. In 2003 and 2004, nearly 500,000 English learners in grades 1-5 took this test each year. The relationship between bilingual education receipt and English proficiency is estimated using value-added…

  16. Pascal, Torricelli et les Données : sur le premier écrit du concours de la roulette

    OpenAIRE

    Maronne , Sébastien

    2017-01-01

    à paraître dans Agnès Cousson (dir.), Passions géométriques. Mélanges en l'honneur de Dominique Descotes, Paris, Champion, 2018.; J'étudie le premier écrit sur le concours de la roulette de Pascal paru à la fin de juin 1658. Après avoir présenté les sources du texte et des figures, je m'intéresse en particulier à l'exemple de la parabole choisi par Pascal pour illustrer la résolution d'un problème en suivant le style des Données d'Euclide. Je montre la filiation de cet exemple à la propositio...

  17. Fire protection concepts for Timber-Glass Composite façades

    Directory of Open Access Journals (Sweden)

    Schleicher Andreas

    2016-01-01

    The main objectives can be summarized as follows: Growth and densification in urban areas require the development of intelligent and resource-efficient building systems for “Smart Cities” of the future. By using timber-glass composites (TGC the primary energy demand of buildings can be reduced substantially. This research project examines the feasibility of applications of this new technology in multi-story and high-rise buildings. Critical aspects concerning fire protection such as flammability of timber elements, fire spread and failure of façade elements with bracing capacity will be analyzed. Different strategies will be developed in case studies and validated by structural analysis. Large scale mock ups of TGC façade elements will be checked on their suitability in fire tests. The findings of this research will lead to innovative fire safety concepts for building systems with TGC façades. Compliance with the high safety standards for multi-story buildings in urban areas like Vienna is one of the main objectives of this work. The adaptation of these fire safety concepts to the national standards of the neighboring countries will be continued subsequently. The gained knowledge should lead to further cooperation with companies for serial productions with TGC technology.

  18. Evaluation of dentoskeletal effects of Farmand functional appliance (Fa II on class II malocclusion

    Directory of Open Access Journals (Sweden)

    Yassaei S.

    2007-07-01

    Full Text Available Background and Aim: Functional appliances refer to a variety of removable or fixed appliances designed to alter the mandibular position both sagitally and vertically, resulting in orthodontic and orthopedic changes. Despite the long history of functional appliances, there is still much controversy related to their effectiveness and mode of action. The aim of this study was to evaluate dental and skeletal effects of Fa II in patients with class II malocclusion due to mandibular deficiency.Materials and Methods: In this before-after clinical trial, 35 patients with class II div I malocclusion were selected. These samples were under treatment with Fa II appliance for 11 months. The range of age of females was 10-13 years and males 11-14 years. Combination analysis was used to determine skeletal and dental effects. Paired t-test was used to compare the differences of mean value pre and post treatment. P<0.05 was considered as the level of significance. Results: There was significant difference between pre and post treatment in respect to posterior and anterior facial height, eruption of upper and lower posterior teeth, eruption of upper anterior teeth, mandibular body length, ANB angle, IMPA and 1 to SN. No significant difference was observed between pre and post treatment regarding facial growth.Conclusion: Treatment with Fa II functional appliance leads to significant alterations in dental and skeletal elements of craniofacial complex and improvement of dental and jaws relationship.

  19. Development and Characterization of a High Sensitivity Segmented Fast Neutron Spectrometer (FaNS-2).

    Science.gov (United States)

    Langford, T J; Beise, E J; Breuer, H; Heimbach, C R; Ji, G; Nico, J S

    2016-01-01

    We present the development of a segmented fast neutron spectrometer (FaNS-2) based upon plastic scintillator and 3 He proportional counters. It was designed to measure both the flux and spectrum of fast neutrons in the energy range of few MeV to 1 GeV. FaNS-2 utilizes capture-gated spectroscopy to identify neutron events and reject backgrounds. Neutrons deposit energy in the plastic scintillator before capturing on a 3 He nucleus in the proportional counters. Segmentation improves neutron energy reconstruction while the large volume of scintillator increases sensitivity to low neutron fluxes. A main goal of its design is to study comparatively low neutron fluxes, such as cosmogenic neutrons at the Earth's surface, in an underground environment, or from low-activity neutron sources. In this paper, we present details of its design and construction as well as its characterization with a calibrated 252 Cf source and monoenergetic neutron fields of 2.5 MeV and 14 MeV. Detected monoenergetic neutron spectra are unfolded using a Singular Value Decomposition method, demonstrating a 5% energy resolution at 14 MeV. Finally, we discuss plans for measuring the surface and underground cosmogenic neutron spectra with FaNS-2.

  20. Flight Test of the F/A-18 Active Aeroelastic Wing Airplane

    Science.gov (United States)

    Voracek, David

    2007-01-01

    A viewgraph presentation of flight tests performed on the F/A active aeroelastic wing airplane is shown. The topics include: 1) F/A-18 AAW Airplane; 2) F/A-18 AAW Control Surfaces; 3) Flight Test Background; 4) Roll Control Effectiveness Regions; 5) AAW Design Test Points; 6) AAW Phase I Test Maneuvers; 7) OBES Pitch Doublets; 8) OBES Roll Doublets; 9) AAW Aileron Flexibility; 10) Phase I - Lessons Learned; 11) Control Law Development and Verification & Validation Testing; 12) AAW Phase II RFCS Envelopes; 13) AAW 1-g Phase II Flight Test; 14) Region I - Subsonic 1-g Rolls; 15) Region I - Subsonic 1-g 360 Roll; 16) Region II - Supersonic 1-g Rolls; 17) Region II - Supersonic 1-g 360 Roll; 18) Region III - Subsonic 1-g Rolls; 19) Roll Axis HOS/LOS Comparison Region II - Supersonic (open-loop); 20) Roll Axis HOS/LOS Comparison Region II - Supersonic (closed-loop); 21) AAW Phase II Elevated-g Flight Test; 22) Region I - Subsonic 4-g RPO; and 23) Phase II - Lessons Learned

  1. Wind tunnel study of natural ventilation of building integrated photovoltaics double skin façade

    Science.gov (United States)

    Hudişteanu, Sebastian Valeriu; Popovici, Cătălin George; Cherecheş, Nelu-Cristian

    2018-02-01

    The paper presents a wind tunnel experimental analysis of a small-scale building model (1:30). The objective of the study is to determine the wind influence on the ventilation of a double skin façade channel (DSF) and the cooling effect over integrated photovoltaic panels. The tests were achieved by conceiving and implementation of an experimental program using a wind tunnel with atmospheric boundary layer. The effect of the wind over the ventilation of the horizontal channels of double skin façades is evaluated for different incident velocities. The results are generalized for the average steady state values of the velocities analysed. The experimental results put in evidence the correlation between the reference wind velocity and the dynamics of the air movement inside the double skin façade. These values are used to determine the convective heat transfer and the cooling effect of the air streams inside the channel upon the integrated photovoltaic panels. The decrease of the photovoltaic panels temperature determines a raise of 11% in efficiency and power generated.

  2. Transport and fate of Herbaspirillum chlorophenolicum FA1 in saturated porous media

    Science.gov (United States)

    Li, X.; Xu, H.; Wu, J.

    2016-12-01

    For the bioremediation of contaminated groundwater, sufficient dispersal of functional microorganisms is one of the most important factors that determine the remediation efficiency. There are extensive studies on the transport of microbes in porous media, while most of them focus on pathogenic bacteria and little attention has been given toward functional bacteria that being used in bioremediation process. Therefore, accurate knowledge of the mechanisms that govern the transport and distribution of such bacteria in groundwater is needed to develop efficient treatment techniques. Herbaspirillum chlorophenolicum FA1, a pure bacterial strain capable of absorbing heavy metals and degrading polycyclic aromatic hydrocarbons (PAHs), was selected as the representative functional bacterium in this study. A series of batch and column experiments were conducted to investigate the transport and deposition behavior of strain FA1 in saturated porous media. The effects of physical (grain size), chemical (ionic strength, humic acid), and biological factors (living/dead cells) were studied in detail. In addition, numerical simulations of breakthrough curve (BTC) data were also performed for information gathering. Results of this study could advance our understanding of functional bacteria transport and help to develop successful bioremediation strategies. This work was financially supported by the National Natural Science Foundation of China -Xinjiang Project (U1503282), the National Natural Science Foundation of China (41030746, 41102148), and the Natural Science Foundation of Jiangsu Province (BK20151385). Keywords: Herbaspirillum chlorophenolicum FA1, bacteria, porous media, transport, modeling

  3. Wind tunnel study of natural ventilation of building integrated photovoltaics double skin façade

    Directory of Open Access Journals (Sweden)

    Hudişteanu Sebastian Valeriu

    2018-01-01

    Full Text Available The paper presents a wind tunnel experimental analysis of a small-scale building model (1:30. The objective of the study is to determine the wind influence on the ventilation of a double skin façade channel (DSF and the cooling effect over integrated photovoltaic panels. The tests were achieved by conceiving and implementation of an experimental program using a wind tunnel with atmospheric boundary layer. The effect of the wind over the ventilation of the horizontal channels of double skin façades is evaluated for different incident velocities. The results are generalized for the average steady state values of the velocities analysed. The experimental results put in evidence the correlation between the reference wind velocity and the dynamics of the air movement inside the double skin façade. These values are used to determine the convective heat transfer and the cooling effect of the air streams inside the channel upon the integrated photovoltaic panels. The decrease of the photovoltaic panels temperature determines a raise of 11% in efficiency and power generated.

  4. QUALITY OF NURSING WORK LIFE IMPROVEMENT MODEL TO DECREASE NURSE INTENTION TO QUIT IN PREMIER SURABAYA HOSPITAL

    Directory of Open Access Journals (Sweden)

    Jany Prihastuty

    2017-04-01

    Full Text Available Introduction: Quality of Nursing Work Life (QNWL is a thing that needs attention by human resource management approach. The purpose of this research was to provide develop model to increase QNWL in order to lower nurse’s intention to quit the Premier Hospital Surabaya. Methods: Design used in the structure was explanatory research. The independent variables was Internal factors (Individual factors, social and environment conceptual factors, operational factors, administrative factors where as the dependent variable from this study was intention to quit, and moderator variables QNWL random sampling technique. Total sample was 160 nurses, taken according to inclusion criteria. The research was conducted in Premier Hospital Surabaya from October 2012 - July 2013. Data were collected by using structured questionnaire. Data were then analyzed by using multiple linear regression test with level of significance of ≤ 0.05. Result: The results showed, QNWL was influenced by relationships inter-professional part of variabel social and environment conceptual factors, supervision monitoring part of variabel operational factors, career development part of variabel administrative factors. Intention to quit influenced by relationships between nurses, inter-departmental and inter-professional part of variabel social and environment conceptual factors and salaries and benefits part of variabel administrative factors with significant value p = 0.005. Discussion: It can be concluded good inter-professional relation, supervision monitoring, and good career development affected QNWL. Good relationships between nurses, inter-departmental and inter- professional led to lower intention to quit. Low salary and benefits led nurse’s intention to quit getting stronger.

  5. Injuries in women's soccer: a 1-year all players prospective field study of the women's Bundesliga (German premier league).

    Science.gov (United States)

    Gaulrapp, Hartmut; Hartmut, Gaulrapp; Becker, Anne; Walther, Markus; Hess, Heinrich

    2010-07-01

    To obtain precise information on injury patterns in the women's premier soccer league in Germany. One-year, prospective, epidemiologic cohort study. Institutional level German Football Association. All 254 players from all 12 women's premier league teams were included. Base information by standardized personal interviews. Evaluation of all injury-associated medical data transmitted by standardized documentation forms. Injuries incidence rates (average, 95% confidence intervals) based on the exposure in matches and at practice. All time loss diagnoses, number and context of injuries related to their anatomical localization, severity, and rehabilitation period were recorded. All 254 players finished the study [average age, 22.8 years (16-35 years)]. Two hundred forty-six injuries amounted to an injury rate of 3.3 per 1000 hours (games, 18.5 per 1000 hours; practice, 1.4 per 1000 hours). Injury distribution: knee, 31.0%; ankle, 22.1%; thigh, 12.9%; and head, 7.1%. The seasonal peak was at the beginning of the competitive season. Injury rates doubled after the 60th minute. Twenty-nine percent of the injuries were severe, and 37% were moderate. Female players suffer a high amount of head injuries and severe knee and ankle injuries. The most common single injury is a sprained ankle. Torn ligaments in the ankle and knee are the most common injuries that require a long recovery period. Most of the severe injuries (>30 days) are due to noncontact intrinsic mechanisms. Almost one-quarter of all injuries consist of exertion syndromes not yet correlated with certain seasonal periods.

  6. English I. [Revised].

    Science.gov (United States)

    Spann, Margaret; And Others

    This manual for language arts instructors contains a basic core of instruction in English that provides updated and extensive vocationally related application of such basic English skills as reading, writing, and practical usage. Attention is also focused on assisting students with life and study skills. The material should be adapted to…

  7. Exploring Affixation in English

    African Journals Online (AJOL)

    unique firstlady

    One of the keys to mastering English spellings is mastering the processes of word formation. The mode of word formation can influence the spelling. The study of the meaningful parts of a word is known as morphology. Linguists have identified many ways in which English form its words which include borrowing from Latin ...

  8. English for Business Communication

    Science.gov (United States)

    Bhatia, Vijay K.; Bremner, Stephen

    2012-01-01

    The concept of Business English has undergone some major shifts in the last few years because of a number of developments, such as advances in genre theory and the coming together of English for Business Purposes and Business Communication, inspired by the realization that there is a gap to be bridged between the academy and the globalized…

  9. Nineteenth-Century English

    DEFF Research Database (Denmark)

    Fabricius, Anne

    2009-01-01

    The article reviews the book "Nineteenth-Century English: Stability and Change," by Merja Kytö, Mats Rydèn and Erik Smitterberg......The article reviews the book "Nineteenth-Century English: Stability and Change," by Merja Kytö, Mats Rydèn and Erik Smitterberg...

  10. Abbreviations in Maritime English

    Science.gov (United States)

    Yang, Zhirong

    2011-01-01

    Aiming at the phenomena that more and more abbreviations occur in maritime English correspondences, the composing laws of the abbreviations in maritime English correspondence are analyzed, and the correct methods to answer the abbreviations are pointed out, and the translation method of abbreviations are summarized in this article, and the…

  11. English for Global Peacekeeping

    Science.gov (United States)

    Crossey, Mark

    2008-01-01

    In this article, I discuss the work of the British Council's Peacekeeping English Project: why the British Council is undertaking this work, why is it being sponsored, what exactly is being done and what are the key issues in English for peacekeeping and other security forces.

  12. Learning English, Learning Science

    Science.gov (United States)

    Nelson, Virginia

    2010-01-01

    Using science notebooks effectively in the classroom can encourage students who are learning English to keep up and keep interested. English language proficiency might head the list of content areas that schools can teach properly and effectively through science. Amaral, Garrison, and Klentschy (2002) reported that a successful inquiry-based…

  13. THE CORRELATION BETWEEN PLAYER VALUATION AND THEBARGAINING POSITIONOF CLUBS IN THE ENGLISH PREMIERLEAGUE (EPL

    Directory of Open Access Journals (Sweden)

    M.J. Swanepoel

    2016-01-01

    Full Text Available Soccer is perhapsthe most lovedgame in the world, filled with passion both onand off the field.Literature suggests that the English Premier League (EPL is oneof the most sought after championship in soccer.The study investigates therelationship between player valuation and the bargaining positions of clubs in theEnglish Premier League (EPL.A comprehensive literatureanalysis illustratesthat the bargaining positions of clubsshouldconsider factors such as previousseasons’ financialperformance,league performance, managerial change andprestige of playing.A quantitative researchapproach using causality was used todetermine the influence of the bargaining positionon players’ valuation in theEPL.The sample of the study comprisesEPL transferred players(n=409 duringthe periodsummer 2012 and winter 2015 transferwindows. Indetermining theresults;correlationanalysisandanalysis of variance (ANOVAwereconductedonthe data.Theresults of the correlation analysis indicatea strong associationbetween the bargaining position of the buying and lower association between thebargaining positions of the selling clubin the influenceofplayer valuation. Intheanalysis ofthe results of the ANOVA the strength of a relationship had avariancespan from non-existent, too weak, to very strong. The ultimate conclusion ofthisstudy based on the results is that valuation of EPL players are often influenced bythebargainingpositions of buyingclubs.Thestudy contributesto the body ofknowledgeon valuation of EPL players provingthatit isdemand-driven,therefore the bargaining position of buying clubs is the determinant.

  14. Evaluating the Effects of Façade Greening on Human Bioclimate in a Complex Urban Environment

    Directory of Open Access Journals (Sweden)

    Britta Jänicke

    2015-01-01

    Full Text Available The evaluation of the effectiveness of countermeasures for a reduction of urban heat stress, such as façade greening, is challenging due to lacking transferability of results from one location to another. Furthermore, complex variables such as the mean radiant temperature (Tmrt are necessary to assess outdoor human bioclimate. We observed Tmrt in front of a building façade in Berlin, Germany, which is half-greened while the other part is bare. Tmrt was reduced (mean 2 K in front of the greened compared to the bare façade. To overcome observational shortcomings, we applied the microscale models ENVI-met, RayMan, and SOLWEIG. We evaluated these models based on observations. Our results show that Tmrt (MD = −1.93 K and downward short-wave radiation (MD = 14.39 W/m2 were sufficiently simulated in contrast to upward short-wave and long-wave radiation. Finally, we compare the simulated reduction of Tmrt with the observed one in front of the façade greening, showing that the models were not able to simulate the effects of façade greening with the applied settings. Our results reveal that façade greening contributes only slightly to a reduction of heat stress in front of building façades.

  15. Spread of smoke and heat along narrow air cavity in double-skin façade fires

    Directory of Open Access Journals (Sweden)

    Chow Lun Cheuk

    2014-01-01

    Full Text Available A scenario on double-skin façade fire was identified earlier for hazard assessment. A flashover room fire occurred next to the façade, broke the interior glass pane and spread to the façade cavity. As observed in experiments, hot gas moved up as a vertical channel flow for narrow façade cavity. Heat and smoke spread along the narrow air cavity of a double-skin façade will be studied in this paper. A simple mathematical model is developed from basic heat transfer theory for studying the vertical air temperature profiles of the hot gas flowing along the cavity. Assuming one-dimensional flow for hot gas moving up the façade cavity, conservation equations on mass and enthalpy were solved. Experimental results on two double-skin façade rigs of height 6 m and 15 m with narrow cavity depth were used to justify the results. A total of 11 tests were carried out. Correlation expressions between cavity air temperature and the height above ceiling of the fire room were derived.

  16. New insights into the operative network of FaEO, an enone oxidoreductase from Fragaria x ananassa Duch.

    Science.gov (United States)

    Collu, Gabriella; Farci, Domenica; Esposito, Francesca; Pintus, Francesca; Kirkpatrick, Joanna; Piano, Dario

    2017-05-01

    The 2-methylene-furan-3-one reductase or Fragaria x ananassa Enone Oxidoreductase (FaEO) catalyses the last reductive step in the biosynthesis of 4-hydroxy-2,5-dimethyl-3(2H)-furanone, a major component in the characteristic flavour of strawberries. In the present work, we describe the association between FaEO and the vacuolar membrane of strawberry fruits. Even if FaEO lacks epitopes for stable or transient membrane-interactions, it contains a calmodulin-binding region, suggesting that in vivo FaEO may be associated with the membrane via a peripheral protein complex with calmodulin. Moreover, we also found that FaEO occurs in dimeric form in vivo and, as frequently observed for calmodulin-regulated proteins, it may be expressed in different isoforms by alternative gene splicing. Further mass spectrometry analysis confirmed that the isolated FaEO consists in the already known isoform and that it is the most characteristic during ripening. Finally, a characterization by absorption spectroscopy showed that FaEO has specific flavoprotein features. The relevance of these findings and their possible physiological implications are discussed.

  17. REMOVAL OF CHEMICAL AND MICROBIAL CONTAMINANTS IN DRINKING WATER - WATTS PREMIER M-2400 POINT-OF-ENTRY REVERSE OSMOSIS DRINKINGWATER TREATMENT SYSTEM

    Science.gov (United States)

    The Watts Premier M-2400 POE RO Drinking Water Treatment System was tested at the NSF Drinking Water Treatment Systems Laboratory for removal of the viruses fr and MS2, the bacteria Brevundimonas diminuta, and chemicals aldicarb, benzene, cadmium, carbofuran, cesium, chl...

  18. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, REMOVAL OF ARSENIC IN DRINKING WATER: WATTS PREMIER M-SERIES M-15,000 REVERSE OSMOSIS TREATMENT SYSTEM

    Science.gov (United States)

    Verification testing of the Watts Premier M-Series M-15,000 RO Treatment System was conducted over a 31-day period from April 26, 2004, through May 26, 2004. This test was conducted at the Coachella Valley Water District (CVWD) Well 7802 in Thermal, California. The source water...

  19. English Grammar For Dummies

    CERN Document Server

    Ward, Lesley J

    2009-01-01

    If you're confused by commas, perplexed by pronouns, and plain terrified by tenses, English Grammar For Dummies will put your fears to rest. Packed with expert guidance, it covers everything from sentence basics to rules even your English teacher didn't know - if you want to brush up on your grammar, this is the only guide you'll ever need. Discover how to: avoid common grammatical errors; get to grips with apostrophes; structure sentences correctly; use verbs and find the right tense; and decide when to use slang or formal English.  

  20. Sustentabilidade do modelo agrícola da bacia do riacho Faé Sustainability of agricultural model of Faé watershed using multivariable analysis

    Directory of Open Access Journals (Sweden)

    Ana Célia Maia Meireles

    2011-03-01

    Full Text Available Este trabalho teve como objetivo avaliar as famílias da parte baixa da bacia hidrográfica do riacho Faé, a partir do modelo agrícola rural existente, utilizando análise multivariada. Foram aplicados questionários do tipo "cross over", com perguntas abertas e fechadas, para a caracterização sócio-econômica e ambiental da região estudada. Para observar as similaridades entre as famílias estudadas aplicou-se a técnica de análises de Agrupamento Hierárquico aos dados. A análise definiu dois grupos bem distintos. O grupo I foi formado por famílias com características tipicamente rurais, envolvendo famílias de baixa renda que desenvolvem as suas atividades produtivas de maneira rudimentar, com o uso de agrotóxicos representando sérios riscos à sustentabilidade do modelo agrícola e, principalmente, à vida dessas famílias. O grupo II demonstrou famílias que, embora localizadas em meio rural, apresentaram características tipicamente urbanas, caracterizadas pela faixa etária predominante jovem, baixa escolaridade e atividade econômica não agrícola. A análise de agrupamento se mostrou eficiente para a distinção dos grupos de famílias homogêneas na área estudada, independentemente de sua localização geográfica.This study aimed to evaluate the families living in the part of the stream Faé watershed. It was based on the existing agricultural model and it was used the multivariate analysis. Forms "cross-over" types with subjective and objective questions were applied for socio-economic and environmental study area. To observe the similarities between the studied families applied Hierarchical Cluster Analysis to data. It was identified two distinct groups. Group I was formed by families with characteristics typically agriculturalist with low income families developing their productive activities in a rudimentary way. Those families use pesticides and they represent a risk both to support agricultural model and to the

  1. AFSC/ABL: Origins of sockeye and chum salmon seized from the F/V Ying Fa

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Samples of chum (Oncorhynchus keta) and sockeye (O. nerka) salmon seized from the stateless fishing vessel Ying Fa were analyzed to determine their region of origin...

  2. Learner Views on English and English Language Teaching in China

    Science.gov (United States)

    Liu, Na; Lin, Chih-Kai; Wiley, Terrence G.

    2016-01-01

    Since the 1980s, China has represented one of the major growth areas in the world for English language education, and studying English has been a priority among its foreign language educational policies. As English has gained more popularity in China, some have noted the potential value of English as a means to greater educational access and…

  3. Teaching English through English: Proficiency, Pedagogy and Performance

    Science.gov (United States)

    Richards, Jack C.

    2017-01-01

    Most of the world's English language teachers speak English as a second or third language rather than as their first language. For many, their level of proficiency in English may not reach benchmarks established by their employers, raising the issue that is the focus of this article, namely, what kind of proficiency in English is necessary to be…

  4. Current status on advanced aqueous reprocessing process (next) in FaCT project

    International Nuclear Information System (INIS)

    Washiya, Tadahiro; Myochin, Munetaka; Koyama, Tomozo

    2009-01-01

    Japan Atomic Energy Agency (JAEA) launched the Fast Reactor Cycle Technology Development (FaCT) project in cooperation with the Japanese electric utilities in 2006. An integration of the advanced aqueous reprocessing concept and the simplified pelletizing fuel fabrication was selected as the most promising fuel cycle system. In order to accomplish the integration, R and D tasks were launched as FaCT Project in 2006 by Japanese joint team. The New Extraction System for TRU Recovery (NEXT) system is an advanced aqueous reprocessing concept which was based on the well established aqueous reprocessing for LWR spent fuel and newly applied processes such as uranium crystallization and extraction chromatography for MAs recovery. Main task of the NEXT process is to develop the TRU recovery process and equipments with high reliability, criticality safety, high durability and remote maintainability. In the FaCT project, all innovative technologies are planned to be developed within the next decade focusing on the future commercialization of FBR cycle systems. The judgment of the adoption of each innovative technology will be made by 2010 based on the results of R and Ds. The development of each technology is to be completed by around 2015. By the same time, it is scheduled to present the conceptual design of commercial and demonstrative fast reactor cycle facilities. The six items (Disassembling and shearing, Fuel dissolution, Uranium Crystallization, Single cycle co-extraction of U, Pu and Np, MA recovery by extraction chromatography and Waste treatment) have been identified as the issues to be developed corresponding to each process step. Current R and D status and prospects of this system until around 2015 is reported. (author)

  5. Recovery from sublethal damage during fractionated irradiation of human FaDu SCC

    International Nuclear Information System (INIS)

    Petersen, Cordula; Zips, Daniel; Krause, Mechthild; Voelkel, Wolfram; Thames, Howard D.; Baumann, Michael

    2005-01-01

    Background and purpose: The present study addresses whether recovery of sublethal damage in tumours may change during fractionated irradiation in FaDu human squamous cell carcinoma and whether such an effect might contribute to the pronounced time factor of fractionated irradiation previously found in this tumour. Patients and methods: FaDu tumours were transplanted s.c. into the right hind leg of NMRI nu/nu mice. Single doses or 2, 4, and 8 equal fractions in 3.5 days were applied in previously unirradiated tumours and after priming with 18 fractions of 3 Gy in 18 or 36 days. All irradiations were given under clamp hypoxic conditions. Experimental endpoints were tumour control dose 50% (TCD 50 ) and α/β values without and after priming. Results: Without priming TCD 50 increased with increasing number of fractions from 38.8 Gy (95% CI 35;45) after single dose irradiation to 54.0 Gy (42;57) after 8 fractions. No increase in TCD 50 when given in 1, 2, 4, or 8 fractions in 3.5 days was found after priming with 18 3-Gy fractions in 18 and 36 days. After priming with 18 fractions in 18 days TCD 50 remained constant at 25 Gy and after priming with 18 fractions in 36 days at 42 Gy. The α/β ratio without priming was 68 Gy (42;127). After fractionated irradiation with 18 3-Gy fractions in 18 and 36 days the α/β ratio increased to 317 Gy (38;∞) and to infinite, respectively. Conclusions: Our results indicate that clonogenic cells in FaDu tumours lose entirely their capacity to recover from sublethal radiation damage during fractionated irradiation. Therefore, an increased repair capacity as an explanation for the pronounced time factor of fractionated irradiation in this tumour can be ruled out

  6. Mouse fetal antigen 1 (mFA1), the circulating gene product of mdlk, pref-1 and SCP-1: isolation, characterization and biology

    DEFF Research Database (Denmark)

    Bachmann, E; Krogh, T N; Højrup, P

    1996-01-01

    residues) revealed 74% identity to hFA1 and 100% identity to the translated cDNAs referred to as mouse dlk, pref-1 and SCP-1. mFA1 is the secreted processed molecule encoded by the mRNA defined by these identical mouse cDNAs. Monospecific rabbit anti-mFA1 antibodies, purified by ammonium sulfate...

  7. Objective and subjective evaluation of façade sound insulation

    DEFF Research Database (Denmark)

    Ordoñez, Rodrigo Pizarro; Visentin, Chiara; Markovic, Milos

    2013-01-01

    by filtering recordings of traffic noise with the frequency response of sound insulation measurements. The measurements were performed in typical Italian buildings in accordance with the ISO 140-5 standard. The objectives of the present paper are to compare the subjective evaluations obtained with the two...... psychoacoustic methods, and to investigate the correlation between subjective assessments and objective ratings in different construction types.......Façade insulation of several different construction types were subjectively evaluated using two psychoacoustic methods: paired comparisons using a two alternative forced choice (2-AFC) paradigm and direct scaling using a visual analogue scale (VAS). The stimuli used in the evaluations were obtained...

  8. The Problem of Biological Destruction of Façades of Insulated Buildings - Causes and Effects

    Science.gov (United States)

    Stanaszek-Tomal, Elżbieta

    2017-10-01

    The Regulation of the Minister of Infrastructure concerning the technical conditions of buildings and their location required new designed buildings to have reduced amount of heat that is transmitted through the barrier. This involves the use of thermal insulation, of adequate thickness to meet the relevant requirements. As the environment conditions are favourable, the façades may deteriorate. Major aggressors include algae fungi or lichens, i.e. the formation of symbiotic growth of algae and fungi. Their construction, metabolic processes are the basis of knowledge about action to prevent corrosion.

  9. Transparent Façade Panel Typologies Based on Recyclable Polymer Materials

    Directory of Open Access Journals (Sweden)

    Harry Giles

    2012-11-01

    Full Text Available Buildings are large consumers of energy. In the United States of America; they constitute over 33% of the total annual energy consumption, produce 35% of the total carbon dioxide emissions and attribute 40% of landfill wastes. The building industry is also a large consumer of non-renewable materials and this trend has escalated dramatically over the past century. It is essential that we find ways to save on energy consumption through the use of solar energy, improved thermal insulation, and alternative efficient glazed façade systems. In this paper, we demonstrate how alternative typologies of transparent and translucent load-bearing façade systems based on biocomposite and recyclable materials, are structurally and thermally efficient at the same time they contribute towards reduced pollutant emissions and non-renewable material uses.Composite insulated panel systems are used extensively in the engineering and building industry, owing to their structural and thermal efficiency. However, these systems are generally opaque and offer little flexibility in building applications. As an alternative, we demonstrate how building products comprised of hybrid material typologie scan be made to perform efficiently as load-bearing façade systems that substitute for current glazing systems with adequate thermal and structural performance, which also possess good light transmission characteristics and integral shading capability. The materials are configured to work as composite panel systems made from a combination of biocomposite and recyclable polymer materials. These materials are environmentally sustainable, because they either originate from naturally grown renewable resources or are recyclable. Our research program includes the design and development of prototype panel systems; the evaluation of structural and thermal performance, together with their role in reducing energy consumption and pollution emission through life cycle analysis. The paper

  10. Glycemic index and glycemic load are associated with some cardiovascular risk factors among the PREMIER study participants

    Directory of Open Access Journals (Sweden)

    Pao-Hwa Lin

    2012-06-01

    Full Text Available Background: The clinical significance of glycemic index (GI and glycemic load (GL is inconclusive. Objective : This study was conducted to examine the association of GI and GL with clinical cardiovascular disease (CVD risk factors including body weight, blood pressure (BP, serum lipids, fasting glucose, insulin and homocysteine over time among the PREMIER participants. Design: PREMIER was an 18-month randomized lifestyle intervention trial, conducted from 2000 to 2002, designed to help participants reduce BP by following the Dietary Approaches to Stop Hypertension (DASH dietary pattern, losing weight, reducing sodium and increasing physical activity. GI and GL were estimated from 24 h diet recall data at baseline, 6 and 18 months after intervention. PROC MIXED model was used to examine the association of changes in GI or GL with changes in CVD risk factors. Results: A total of 756 randomized participants, 62% females and 34% African Americans and who averaged 50.0±0.3 years old and 95.3±0.7 kg, were included in this report. Neither GI nor GL changes was associated with changes in any risk factors at 6 months. At 18 months, however, the GI change was significantly and positively associated with total cholesterol (TC change only (p<0.05, β = 23.80±12.11 mg/dL or 0.62±0.31 mmol/L with a significant age interaction. The GL change was significantly associated with TC (p=0.02, β = 0.28±0.15 mg/dL or 0.01±0.00 mmol/L positively and with low density lipoprotein cholesterol (LDL-C changes negatively (p=0.03, β = − 0.01±0.00 mg/dL or −0.00±0.00 mmol/L, and significant age interactions were observed for both. Conclusion: GI and GL was associated with TC and LDL-C after controlling for energy, fat and fiber intake and other potential confounders and the associations were modified by age. Further investigation into this relationship is important because of its potential clinical impact.

  11. Variations in Written English

    National Research Council Canada - National Science Library

    Collins, Jeffrey

    2003-01-01

    .... The implication is that these five dimensions mark fundamental rhetorical "cut points" in written English, functioning as a heretofore hidden meso-layer linking micro-level linguistic decisions...

  12. Studies on watermelon somatic cell mutant of resistance to fusaric acid (FA) by low energy Ar+ ion beam irradiation

    International Nuclear Information System (INIS)

    Wang Haobo; Gu Yunhong; Cheng Guowang; Yu Zengliang

    2003-01-01

    Three kinds of watermelon seeds irradiated by Ar + ion beam (25 keV, 6.24 x 10 16 ions/cm 2 ) were inoculated in MS medium with 15 mg/L FA. Cotyledons from the sterile seedling as explants were inoculated in MS +BA 2.0 mg/L + FA 15 mg/L. And the adventitious shoots of resistance to FA were cultured in MS + NAA 0.2 mg/L + FA 15 mg/L. The results showed that both the irradiation of Ar + and FA affected the germination rate and seedling of watermelon line 3-27 and YH-5, and the joint effect of Ar + and FA showed an enhanced restraint. The adventitious shoot and rootage induction rate from the seeds irradiated by Ar + were respectively bigger than the unirradiated seeds in 3-27 and YH-5. The increasing ranges were different between two watermelon lines and between the shoot and rootage induction rates

  13. Teaching English through Movies

    OpenAIRE

    Groger, Kenneth

    2004-01-01

    In this paper I will offer some techniques on how to add stimulation and enjoyment to the study of English through watching movies. The reader will have a chance to examine how teachers can utilize movies in the classroom to generate significant language production. This paper will further demonstrate how movies provide a plethora of opportunities for learners to reinforce and integrate all four English language skills, while improving their ability to engage in discussions that elicit and en...

  14. My Hesitation to Speak English

    Science.gov (United States)

    Oda, Naruha

    2015-01-01

    Even though English was the author's favorite subject, she was not good at speaking in English, and always tried to avoid it. However, it did not matter because she did not have to speak to demonstrate her English ability. After entering university, her lack of confidence in speaking English became a major issue, and other students face the same…

  15. Attitudes Toward English in Malaysia.

    Science.gov (United States)

    Crismore, Avon; And Others

    1996-01-01

    A 16-item Likert Scale questionnaire was used to investigate the perceptions and attitudes of Malaysian teachers and students at the university level toward Malaysian English. The functionality of Malaysian English was accepted, but respondents were determined to learn Standard English because they viewed Malaysian English as "wrong…

  16. English Language Teaching Profile: Cyprus.

    Science.gov (United States)

    British Council, London (England). English-Teaching Information Centre.

    This profile in outline form of the English language teaching situation in Cyprus discusses the role of English within the Greek Cypriot community and within the educational system. Areas covered include English language requirements and English within the curriculum, teaching personnel and teacher training, instructional materials, English…

  17. English made easy

    CERN Document Server

    Crichton, Jonathan

    2013-01-01

    This is a fun and user–friendly way to learn English English Made Easy is a breakthrough in English language learning—imaginatively exploiting how pictures and text can work together to create understanding and help learners learn more productively. It gives learners easy access to the vocabulary, grammar and functions of English as it is actually used in a comprehensive range of social situations. Self–guided students and classroom learners alike will be delighted by the way they are helped to progress easily from one unit to the next, using a combination of pictures and text to discover for themselves how English works. The pictorial method used in this book is based on a thorough understanding of language structure and how language is successfully learned.English Made Easy, Volume 1 consists of a total of 20 units arranged in groups of five. The first four units presents language and provide learners the opportunities to practice as they learn. The first page of each unit has a list of all the word...

  18. English made easy

    CERN Document Server

    Crichton, Jonathan

    2013-01-01

    This is a fun and user–friendly way to learn EnglishEnglish Made Easy is a breakthrough in English language learning—imaginatively exploiting how pictures and text can work together to create understanding and help learners learn more productively. It gives learners easy access to the vocabulary, grammar and functions of English as it is actually used in a comprehensive range of social situations. Self–guided students and classroom learners alike will be delighted by the way they are helped to progress easily from one unit to the next, using a combination of pictures and text to discover for themselves how English works. The pictorial method used in this book is based on a thorough understanding of language structure and how language is successfully learned.English Made Easy, Volume 2 consists of a total of 20 units arranged in groups of five. The first four units presents language and provide learners the opportunities to practice as they learn. The first page of each unit has a list of all the words...

  19. English Tsunami in Indonesian

    Directory of Open Access Journals (Sweden)

    E. Sadtono

    2013-11-01

    Full Text Available English has successfully overwhelmed Indonesian like tsunami as an imperialistic language. The meaning of imperialism here, however, differs from the conventional meaning as it is invited imperialism, not coerced imperialism.The influence of English in Indonesian is discussed in terms of modernization, globalization, economy, and history. The linguistic tsunami effects are overwhelming, staggering, and unstoppable. The data for this article were collected from various sources, and it was found that the number of English words (pure and modified is indeed confounding. Virtually English words have penetrated all walks of life. Unfortunately, there is no way we can prevent English influence on Indonesian, it is simply inevitable and we cannot do anything about it. Seen from linguistic purism, we have lost the battle in fighting off English influence; but seen from the eye of a descriptive linguist, it is an unpreventable historical phenomenon. It is a lingusitic dynamism in which language is altered and enriched by a continuous input from other languages, the most influential language being the major donor of loanwords of the receiving language. If it is considered a problem, the solution is to change our attitude to realize that any living language continues undergoing modifications and we should be willing to accommodate them. It is the dialectics of world history.

  20. Design of MiSolFA Hard X-Ray Imager

    Science.gov (United States)

    Lastufka, Erica; Casadei, Diego

    2017-08-01

    Advances in the study of coronal electron-accelerating regions have so far been limited by the dynamic range of X-ray instruments. A quick and economical alternative to desirable focusing optics technology is stereo observation. The micro-satellite MiSolFA (Micro Solar-Flare Apparatus) is designed both as a stand-alone X-ray imaging spectrometer and a complement to the Spectrometer/Telescope for Imaging X-rays (STIX) mission. These instruments will be the first pair of cross-calibrated X-ray imaging spectrometers to look at solar flares from very different points of view. MiSolFA will achieve indirect imaging between 10 and 60 keV and provide spectroscopy up to 100 keV, equipped with grids producing moiré patterns in a similar way to STIX. New manufacturing techniques produce gold gratings on a graphite or silicon substrate, with periods ranging from 15 to 225 micrometers, separated by a distance of 15.47 cm, to achieve a spatial resolutions from 10" to 60" (as compared to RHESSI's separation of 150 cm and 1" resolution). We present the progress of the imager design, the performance of the first prototypes, and reach out to the community for further scientific objectives to consider in optimizing the final design.

  1. Thermal Performance of Ventilated Double Skin Façades with Venetian Blinds

    Directory of Open Access Journals (Sweden)

    Jordi Parra

    2015-05-01

    Full Text Available Venetian blinds (VB are shading devices of widespread use in residential and corporate buildings. They can reflect or transmit light into buildings and at the same time allow daylighting and exterior views. They can also efficiently block radiative heat from entering the building, and if combined with a heat dissipation system such as forced ventilation, they can improve the thermal performance of double skin façades (DSF. Computational Fluid Dynamics (CFD has proven to be a useful tool for modeling flow and heat transfer in DSF, including conduction, convection and radiation heat transfer phenomena. The aim of this work is to evaluate, by means of CFD, the influence of several optical, construction and operation parameters of a DSF (such as optical properties of the materials, geometrical relations of the VB or flow stream conditions in terms of energy savings, measured as a reduction of the solar load entering the building. Results obtained show that parameters such as the proximity of the VB to the exterior skin of the façade or a differentiated surface treatment for the exterior and interior faces of the VB louvers can notably affect the thermal performance of the DSF and hence the heat gains experienced by the building.

  2. Climate Based Façade Design for Business Buildings with Examples from Central London

    Directory of Open Access Journals (Sweden)

    John Napier

    2015-01-01

    Full Text Available There is a disconnection between commercial architecture and environmental thinking, where green features can be included as part of a strategy for gaining approvals and marketing projects, but those features are not reviewed after completion and occupation of the building and knowledge is not shared. High levels of air conditioning are still considered unavoidable. Elaborate double skin façades and complex motorized shading systems are adopted; often masking an underlying lack of basic environmental thinking. This article returns (in principle to the physics of comfort in buildings and the passive strategies which can help achieve this with a low energy and carbon footprint. Passive and active façade design strategies are outlined as the basis of a critical tool and a design methodology for new projects. A new architectural sensibility can arise based on modeling the inputs of sunlight, daylight and air temperature in time and space at the early stages of design. Early but sound strategies can be tested and refined using advanced environmental modeling techniques. Architecture and environmental thinking can proceed hand in hand through the design process.

  3. Comparison and development of sustainable office façade renovation solutions in the Netherlands

    Directory of Open Access Journals (Sweden)

    Michiel Ritzen

    2013-12-01

    Full Text Available Environmental, commercial and societal developments in the Netherlands stimulate the environmental improvement of the existing office building stock. In the Netherlands, about 15% of all office area was vacant in 2012, and the majority of offices have a relative poor energy performance. To measure the improvement, different assessment tools are applied. These tools either focus on one aspect, such as operation energy, and result in a specific outcome such as MJ/m2, or these tools combine different aspects, such as energy and materials, through a weighted system and result in a generic outcome, such as ‘excellent’.In this research, the relation between assessment outcome and actual environmental impact is investigated of both types of tools, by reflecting the outcome of the tool to the carrying capacity of a system. The relation is investigated through a comparison of the energy and material aspect of three office façade renovation solutions using four different assessment tools. Using a tool in which energy and material impact is related to the carrying capacity, current energy focused optimization might lead to a sub optimization of actual environmental impact. To illustrate this, a calculated façade solution is presented with minimal environmental impact based on carrying capacity.

  4. Color Image Evaluation for Small Space Based on FA and GEP

    Directory of Open Access Journals (Sweden)

    Li Deng

    2014-01-01

    Full Text Available Aiming at the problem that color image is difficult to quantify, this paper proposes an evaluation method of color image for small space based on factor analysis (FA and gene expression programming (GEP and constructs a correlation model between color image factors and comprehensive color image. The basic color samples of small space and color images are evaluated by semantic differential method (SD method, color image factors are selected via dimension reduction in FA, factor score function is established, and by combining the entropy weight method to determine each factor weights then the comprehensive color image score is calculated finally. The best fitting function between color image factors and comprehensive color image is obtained by GEP algorithm, which can predict the users’ color image values. A color image evaluation system for small space is developed based on this model. The color evaluation of a control room on AC frequency conversion rig is taken as an example, verifying the effectiveness of the proposed method. It also can assist the designers in other color designs and provide a fast evaluation tool for testing users’ color image.

  5. Estimation de la survie des alevins de carpe (C. carpio au cours de leur premier mois d'existence

    Directory of Open Access Journals (Sweden)

    MOREAU J.

    1979-10-01

    Full Text Available Des observations réalisées sur deux stations piscicoles de Madagascar, dans des étangs ne recevant ni engrais ni nourriture, révèlent qu'au cours de leur premier mois les alevins de carpe (C. carpio subissent des mortalités voi-sines de 50 %. Ces dernières sont encore plus élevées en début et en fin de saison de reproduction. Au début, les fortes mortalités sont dues à la température trop basse et aux disponibilités alimentaires insuffisantes ; en fin de saison de reproduction, la température trop élevée et la mauvaise qualité des œufs sont sans doute en cause. Une fumure adéquate des étangs de grossissement des alevins et une alimentation correcte des géniteurs permettront peut-être de diminuer ces mortalités.

  6. Incidence, nature, and pattern of injuries to referees in a premier football (soccer) league: a prospective study.

    Science.gov (United States)

    Kordi, Ramin; Chitsaz, Alireza; Rostami, Mohsen; Mostafavi, Reza; Ghadimi, Mahmoodreza

    2013-09-01

    Despite the crucial role of referees in a soccer match, few researchers have targeted the injury profile of referees in their studies. Understanding the incidence, nature, and pattern of injuries could provide important information for educational and preventative efforts at the international level. The incidence rate and patterns of acute injuries to official referees of the Iranian Premier Football League during the 2009-2010 season are similar to those reported among referees in short-term international competitions such as FIFA World Cup. Prospective cohort study. Demographic data for 74 referees, including 30 main referees and 44 assistant referees, were collected at the beginning of the season. To record injuries and refereeing time, weekly contact was made by a physician. In total, 102 injuries were reported by referees during the football season. The incidence rates of injuries among referees during training and matches were 4.6 and 19.6 injuries per 1000 hours, respectively. Muscular and tendon injuries were found to be the most common type of injury, and the most common site of injury was the lower leg followed by the hip and groin. The results of this study are consistent with similar prospective studies evaluating injuries to referees over the course of a short-term tournament. These findings provide a base for suggesting possible preventive recommendations in future studies.

  7. Computer-simulation study on fire behaviour in the ventilated cavity of ventilated façade systems

    Directory of Open Access Journals (Sweden)

    Giraldo María P.

    2013-11-01

    Full Text Available Fire spread through the façades is widely recognized as one of the fastest pathways of fire spreading in the buildings. Fire may spread through the façade in different ways depending on the type of façade system and on the elements and materials from which it is constructed. Ventilated façades are multilayer systems whose main feature is the creation of an air chamber of circulating air between the original building wall and the external cladding. The “chimney effect” in the air cavity is a mechanism that improves the façade's thermal behaviour and avoids the appearance of moisture from rain or condensation. However, in a event of fire, it may contribute to the quickest spreading of fire, representing a significant risk to the upper floors of a building. This study deals with some aspects of fire propagation through the ventilated cavity in ventilated façade systems. Also we review the provisions stipulated by the Spanish building code (Código Técnico de la Edificación, CTE [1] to avoid fire spread outside the building. The results highlight the importance of the use of proper fire barriers to ensure the compartmentalization of the ventilated cavity, as well as the use of non-combustible thermal insulation materials, among others. In addition, based on the results, it might be considered that the measures stipulated by the CTE are insufficient to limit the risks associated with this kind of façades systems. The study has been performed using field models of computational fluid-dynamics. In particular, the Fire Dynamics Simulator (FDS software has been used to numerically solve the mathematical integration models.

  8. Diffusion tensor imaging: the normal evolution of ADC, RA, FA, and eigenvalues studied in multiple anatomical regions of the brain

    Energy Technology Data Exchange (ETDEWEB)

    Loebel, Ulrike [University Hospital Jena, Institute of Diagnostic and Interventional Radiology, Jena (Germany); St. Jude Children' s Research Hospital, Department of Radiological Sciences, Memphis, TN (United States); Sedlacik, Jan [St. Jude Children' s Research Hospital, Department of Radiological Sciences, Memphis, TN (United States); University Hospital Jena, Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena (Germany); Guellmar, Daniel [University Hospital Jena, Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena (Germany); University Hospital Jena, Biomagnetic Center, Department of Neurology, Jena (Germany); Kaiser, Werner A.; Mentzel, Hans-Joachim [University Hospital Jena, Institute of Diagnostic and Interventional Radiology, Jena (Germany); Reichenbach, Juergen R. [University Hospital Jena, Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena (Germany)

    2009-04-15

    The aim of our work was to investigate the process of myelination in healthy patients using the diffusion parameters apparent diffusion coefficient (ADC), relative anisotropy (RA), fractional anisotropy (FA), and eigenvalues. Age-dependent changes were assessed using the slope m of the fit functions that best described the data. Seventy-two patients (3 weeks-19 years) without pathological magnetic resonance imaging findings were selected from all pediatric patients scanned with diffusion tensor imaging over a 5-year period at our institution. ADC, RA, FA, and eigenvalue maps were calculated and regions of interest were selected in anterior/posterior pons, genu/splenium of corpus callosum (CC), anterior/posterior limb of internal capsule (IC), and white matter (WM) regions (frontal, temporal, parietal, occipital WM). Statistical analysis was performed using Spearman correlation coefficient and regression analysis. Mean values ranged 71.6 x 10{sup -5} to 90.3 x 10{sup -5} mm{sup 2}/s (pons/parietal WM) for ADC, 0.32-0.94 (frontal WM/CC) for RA, and 0.36-0.81 (frontal WM/splenium) for FA. Logarithmic fit functions best described the data. Strong age influences were observed for CC, pons, and parietal/frontal WM and changes were significant for all three eigenvalues, most pronounced for perpendicular eigenvalues. Changes in RA and FA differed depending on the structure anisotropy. Changes observed for ADC, RA, FA, and eigenvalues with age were consistent with previous findings. Changes detected for RA and FA varied due to the different scaling of both parameters. We found that the use of the largely linear scaled RA adds more valuable information for the assessment of age-dependent structural changes as compared to FA. Additionally, we report normative values for the diffusion parameters studied. (orig.)

  9. pH-sensitive Au-BSA-DOX-FA nanocomposites for combined CT imaging and targeted drug delivery.

    Science.gov (United States)

    Huang, He; Yang, Da-Peng; Liu, Minghuan; Wang, Xiangsheng; Zhang, Zhiyong; Zhou, Guangdong; Liu, Wei; Cao, Yilin; Zhang, Wen Jie; Wang, Xiansong

    2017-01-01

    Albumin-based nanoparticles (NPs) as a drug delivery system have attracted much attention owing to their nontoxicity, non-immunogenicity, great stability and ability to bind to many therapeutic drugs. Herein, bovine serum albumin (BSA) was utilized as a template to prepare Au-BSA core/shell NPs. The outer layer BSA was subsequently conjugated with cis -aconityl doxorubicin (DOX) and folic acid (FA) to create Au-BSA-DOX-FA nanocomposites. A list of characterizations was undertaken to identify the successful conjugation of drug molecules and targeted agents. In vitro cytotoxicity using a cell counting kit-8 (CCK-8) assay indicated that Au-BSA NPs did not display obvious cytotoxicity to MGC-803 and GES-1 cells in the concentration range of 0-100 μg/mL, which can therefore be used as a safe drug delivery carrier. Furthermore, compared with free DOX, Au-BSA-DOX-FA nanocomposites exhibited a pH-sensitive drug release ability and superior antitumor activity in a drug concentration-dependent manner. In vivo computed tomography (CT) imaging experiments showed that Au-BSA-DOX-FA nanocomposites could be used as an efficient and durable CT contrast agent for targeted CT imaging of the folate receptor (FR) overexpressed in cancer tissues. In vivo antitumor experiments demonstrated that Au-BSA-DOX-FA nanocomposites have selective antitumor activity effects on FR-overexpressing tumors and no adverse effects on normal tissues and organs. In conclusion, the Au-BSA-DOX-FA nanocomposite exhibits selective targeting activity, X-ray attenuation activity and pH-sensitive drug release activity. Therefore, it can enhance CT imaging and improve the targeting therapeutic efficacy of FR-overexpressing gastric cancers. Our findings suggest that Au-BSA-DOX-FA nanocomposite is a novel drug delivery carrier and a promising candidate for cancer theranostic applications.

  10. pH-sensitive Au–BSA–DOX–FA nanocomposites for combined CT imaging and targeted drug delivery

    Science.gov (United States)

    Huang, He; Yang, Da-Peng; Liu, Minghuan; Wang, Xiangsheng; Zhang, Zhiyong; Zhou, Guangdong; Liu, Wei; Cao, Yilin; Zhang, Wen Jie; Wang, Xiansong

    2017-01-01

    Albumin-based nanoparticles (NPs) as a drug delivery system have attracted much attention owing to their nontoxicity, non-immunogenicity, great stability and ability to bind to many therapeutic drugs. Herein, bovine serum albumin (BSA) was utilized as a template to prepare Au–BSA core/shell NPs. The outer layer BSA was subsequently conjugated with cis-aconityl doxorubicin (DOX) and folic acid (FA) to create Au–BSA–DOX–FA nanocomposites. A list of characterizations was undertaken to identify the successful conjugation of drug molecules and targeted agents. In vitro cytotoxicity using a cell counting kit-8 (CCK-8) assay indicated that Au–BSA NPs did not display obvious cytotoxicity to MGC-803 and GES-1 cells in the concentration range of 0–100 μg/mL, which can therefore be used as a safe drug delivery carrier. Furthermore, compared with free DOX, Au–BSA–DOX–FA nanocomposites exhibited a pH-sensitive drug release ability and superior antitumor activity in a drug concentration-dependent manner. In vivo computed tomography (CT) imaging experiments showed that Au–BSA–DOX–FA nanocomposites could be used as an efficient and durable CT contrast agent for targeted CT imaging of the folate receptor (FR) overexpressed in cancer tissues. In vivo antitumor experiments demonstrated that Au–BSA–DOX–FA nanocomposites have selective antitumor activity effects on FR-overexpressing tumors and no adverse effects on normal tissues and organs. In conclusion, the Au–BSA–DOX–FA nanocomposite exhibits selective targeting activity, X-ray attenuation activity and pH-sensitive drug release activity. Therefore, it can enhance CT imaging and improve the targeting therapeutic efficacy of FR-overexpressing gastric cancers. Our findings suggest that Au–BSA–DOX–FA nanocomposite is a novel drug delivery carrier and a promising candidate for cancer theranostic applications. PMID:28435261

  11. Color Vision and the Railways: Part 3. Comparison of FaLant, OPTEC 900, and Railway LED Lantern Tests.

    Science.gov (United States)

    Dain, Stephen J; Casolin, Armand; Long, Jennifer

    2015-02-01

    The Farnsworth Lantern (FaLant) and the OPTEC 900 are nominated in the Commission Internationale de l'Éclairage (CIE) Color Vision Standard 2. Neither test uses the railway signal color code of red, yellow, and green, and only the OPTEC 900 is commercially available. The Railway LED Lantern Test (RLLT) is based on railway signaling practices in New South Wales, Australia, and is nominated in the Australian railway medical standard. The objective of this study is to compare the performance of the three lantern tests. The RLLT, FaLant, and OPTEC 900 were administered to 46 color vision-normal and 37 color vision-deficient (CVD) subjects. The pattern of errors on the RLLT was different from that of the FaLant and OPTEC 900. This may be accounted for, at least in part, by the different colors and the use of blank presentations in the RLLT. The three lanterns showed agreement in failing 21 and passing 6 of the CVD subjects (72.9%). The lanterns gave different results for 10 CVD subjects (27.9%): n = 5 passed only the RLLT and n = 3 passed only the FaLant; n = 1 failed only the FaLant and n = 1 failed only the RLLT. The overall failure rate by CVD for each lantern was 67.6% (RLLT), 73.0% (FaLant), and 78.4% (OPTEC 900). Despite the different construction principles, the pass/fail levels of the RLLT, FaLant, and OPTEC 900 are comparable and consistent with the performance of other lanterns listed by the CIE for Color Vision Standard 2. The RLLT may be a little easier to pass and is based on the signal color code used and actual signaling practice. We propose that the RLLT is also an appropriate lantern for CIE Color Vision Standard 2.

  12. NEGATION AFFIXES IN ENGLISH

    Directory of Open Access Journals (Sweden)

    Dedy Subandowo -

    2017-02-01

    Full Text Available Abstract: This research entitled "Negation Affixes in English". This study is aimed to describe the various negation affixes in English, morphological process, morphophonemic and meaning. The research data were taken from various sources of English grammar book, morphology, research journal and the book which relatees to the research. English grammar books used in this study are written by Otto Jesperson, Marcella Frank, Greenbaum and Geoffrey Leech.  The method used in this research is the descriptive-qualitative method. While the data collection techniques are performed by using jot-down method. And the results of analysis are presented in tabular form and descriptive method. The result of the research shows that English has six types of negative affixes which are categorized by the intensity of its appearance, such as dis-, in-, non-, un-, anti- and -less. Based on the function, negation affixes are divided into several categories such as adjectives, nouns, verbs, and adverbs. The morphophonemic affix in- has four allomorphs, they are in-, im-, il- and ir- . While the analysis revealed that negation affixes have some basic meanings, such as ‘not’, ‘without’, and ‘anti’.

  13. School of Juridical English

    Directory of Open Access Journals (Sweden)

    I. G. Fedotova

    2014-01-01

    Full Text Available The Department of English Language № 8 works with students of the Faculty of International Law. The unique school of teaching legal aspects of the English language is one of the most significant achievements of the department. Associate Professor V.F. Nazarov was one of professionals, was at the origin of this school. In 1992 the textbook "The course of the legal interpretation of Anglo-American Commercial Law" was published, which was the result of work of group of specialists in legal translation since early 1970s. The book laid foundation for the further development of the school of teaching legal aspects of the English language. After1990stheteaching of the legal aspects of English language was brought to the next level, marked of the by the creation of the educational complex "Legal concepts and categories in the English language" by I.G. Fedotova and G.P. Tolstopyatenko, based on the new competence-based concept of educating professional international lawyers.

  14. The dam replacing gene product enhances Neisseria gonorrhoeae FA1090 viability and biofilm formation.

    Science.gov (United States)

    Kwiatek, Agnieszka; Bacal, Pawel; Wasiluk, Adrian; Trybunko, Anastasiya; Adamczyk-Poplawska, Monika

    2014-01-01

    Many Neisseriaceae do not exhibit Dam methyltransferase activity and, instead of the dam gene, possess drg (dam replacing gene) inserted in the leuS/dam locus. The drg locus in Neisseria gonorrhoeae FA1090 has a lower GC-pairs content (40.5%) compared to the whole genome of N. gonorrhoeae FA1090 (52%). The gonococcal drg gene encodes a DNA endonuclease Drg, with GmeATC specificity. Disruption of drg or insertion of the dam gene in gonococcal genome changes the level of expression of genes as shown by transcriptome analysis. For the drg-deficient N. gonorrhoeae mutant, a total of 195 (8.94% of the total gene pool) genes exhibited an altered expression compared to the wt strain by at least 1.5 fold. In dam-expressing N. gonorrhoeae mutant, the expression of 240 genes (11% of total genes) was deregulated. Most of these deregulated genes were involved in translation, DNA repair, membrane biogenesis and energy production as shown by cluster of orthologous group analysis. In vivo, the inactivation of drg gene causes the decrease of the number of live neisserial cells and long lag phase of growth. The insertion of dam gene instead of drg locus restores cell viability. We have also shown that presence of the drg gene product is important for N. gonorrhoeae FA1090 in adhesion, including human epithelial cells, and biofilm formation. Biofilm produced by drg-deficient strain is formed by more dispersed cells, compared to this one formed by parental strain as shown by scanning electron and confocal microscopy. Also adherence assays show a significantly smaller biomass of formed biofilm (OD570 = 0.242 ± 0.038) for drg-deficient strain, compared to wild-type strain (OD570 = 0.378 ± 0.057). Dam-expressing gonococcal cells produce slightly weaker biofilm with cells embedded in an extracellular matrix. This strain has also a five times reduced ability for adhesion to human epithelial cells. In this context, the presence of Drg is more advantageous for N. gonorrhoeae biology than

  15. Business management replication from established market to emerging market: An analysis of the Indian Premier League from the Bangladesh market perspective

    OpenAIRE

    Shams, S M Riad

    2012-01-01

    This paper attempts to analyze the critical factors that would be crucial to replicating business management strategies from established market to emerging market. A case study is conducted on the Indian Premier League market and Bangladesh market, while these markets are considered as established and emerging markets of the Twenty20 cricket business consecutively. Seven critical factors are identified from the study as crucial in case of replicating business management strategies from establ...

  16. Polychromie et représentations apotropaïques sur la façade de l'église du Saint-sauveur a Žiča

    Directory of Open Access Journals (Sweden)

    Čanak-Medić Milka

    2006-01-01

    Full Text Available (francuski Seules les descriptions de l'aspect extérieur de l'église de l'Ascension du Christ a Decani recourent a des termes aussi élogieux que ceux employés roi parler de l'église du Saint-Sauveur a Žiča. Et, de fait, La beauté de cette dernière a notamment été tout particulièrement soulignée par les anciens écrivains, Domentijan et Teodosije. Tout le sens de leurs paroles n'a toutefois été perf qu'a la suite de récents travaux de restauration entrepris sur l'église s'étant soldes par le dégagement de restes de couches de peinture recouvrant ses murs extérieurs et ayant, de ce fait, permis d'entrevoir l'aspect originel de la décoration poly chromatique extérieur de l'église. Les premières connaissances concernant la décoration des façades de l'église de Žiča remontent aux années vingt du XXe siècle. On a alors dégage deux couches dont la plus récente a été datée de la quatrième décennie du XIV femme siècle (fig. 3, 4 alors qu'a plusieurs endroits a été constatée au-dessous de celle-ci, la couche de crépis originelle. Celle-ci recouvrait toutes les surfaces des murs a 1'exception des corniches, des frises des arcades et, vraisemblablement, des cadres des fenêtres (fig. 5, 6. La datation exacte de cette couche inferieure de crépis a été possible grâce aux résultats de sondages effectues a la jonction des portiques précédant les par églises et, respectivement, des murs sud et nord de 1'exonarthex, ériges au plus tard en 1230. Sur la partie frontale du mur du portique précédent la par église sud dédiée au saint premier martyr Etienne subsiste les restes d'une croix ornee de pierres précieuses: creux gem mata, d'une grande taille au-dessus de laquelle apparait la partie inferieure d'une figure de saint (fig. 1, 7, 8, 10 alors que sur la façade du portique nord on relève les traces d'une composition historiée non identifiable (fig. 12. II est donne question d'une trouvaille fermée dont

  17. English for international journalists

    CERN Document Server

    Gandon, Mike

    2013-01-01

    English for International Journalists is a clear and engaging step-by-step guide for non-native speakers using English in journalism across all forms of media. In-depth language analysis is provided in the specialised context of journalism, as well as a comprehensive approach to the rules and guidelines necessary for avoiding the pitfalls and errors that undermine accuracy and clarity. The book, written by Mike Gandon and edited by Heather Purdey, covers a broad range of vital subjects, including: Making contact Interviewing Grammar and journalistic writing Sensitive issues The language of argument The language of impartial and accurate reporting Bloggers and broadcasters Reporting economy, health and the environment. The book is closely supported by online resources concentrating on the spoken word, intonation and pronunciation, and also features an expansive range of exercises and tests, suitable for self-study or to be set as coursework. English for International Journalists presents readers with ...

  18. English Book Club

    CERN Multimedia

    CERN English Book Club

    2010-01-01

    AGM  --  AGM  -- 2010 --  AGM  --  AGM The CERN ENGLISH BOOK CLUB will hold its 2010 AGM at 18h00 on Monday November 22nd in the club rooms (club barrack 564). Club members are invited to attend. Any members wishing to add points on to the agenda should contact one of the committee before November 12th. AGM  --  AGM  -- 2010 --  AGM  --  AGM The English Book Club has a collection of over 4500 English language books, mostly general fiction with a sprinkling of nonfiction and children’s books. New books are purchased regularly and the books are shelved in our club room which is accessible to members at all times. Membership is open to all (staff and external) and there is a special tariff for short term students. See the club’s website at http://cern.ch/englishbookclub for more details.  

  19. English Book Club

    CERN Multimedia

    English Book Club

    2012-01-01

    The CERN English Book Club will hold its 2012 AGM at 17h30 on Monday 5th March in the club rooms (club barrack 564). Club members are invited to attend. Any members wishing to add points on to the agenda should contact one of the committee before February 27th. The English Book Club has a collection of over 4500 English language books, mostly general fiction with a sprinkling of nonfiction and children’s books. New books are purchased regularly and the books are shelved in our club room which is accessible to members at all times. Membership is open to all (staff and external) and there is a special tariff for short term students. See the club’s website at http://cern.ch/englishbookclub for more details.

  20. A Decision Support Concept for a construction design project – selecting the type of glass façade

    Directory of Open Access Journals (Sweden)

    Franjo Šimić

    2017-01-01

    Full Text Available The paper describes research into the possibility of developing a concept for supporting decisions in planning construction projects (one of the most important stages of construction project management. The focus is on supporting decisions in selecting the type of and solution for the glass façade in the main design. Materials and types of soluteons for a glass façade were analyzed and alternative solutions were obtained. The concept was developed in that it included relevant stakeholders in the decision-making process during the construction design. These stakeholders were the investor, architect, and construction contractor. The analysis was carried out and a hierarchical structure of objectives was formed as a goal tree. The criteria at the last hierarchical level were used to evaluate alternative solutions for the glass façade, and their weights were determined by all stakeholders using the AHP method (Analytic Hierarchy Process. Using PROMETHEE (Preference Ranking Method for Enrichment Evaluation, a comparison of alternative solutions for the glass façade was conducted and the alternatives were ranked according to the priorities for inclusion into the main design. The concept was tested by selecting a type of glass façade on a residential-commercial building in the city of Rijeka, Croatia.

  1. An enhanced functional ability questionnaire (faVIQ) to measure the impact of rehabilitation services on the visually impaired.

    Science.gov (United States)

    Wolffsohn, James Stuart; Jackson, Jonathan; Hunt, Olivia Anne; Cottriall, Charles; Lindsay, Jennifer; Gilmour, Richard; Sinclair, Anne; Harper, Robert

    2014-01-01

    To develop a short, enhanced functional ability Quality of Vision (faVIQ) instrument based on previous questionnaires employing comprehensive modern statistical techniques to ensure the use of an appropriate response scale, items and scoring of the visual related difficulties experienced by patients with visual impairment. Items in current quality-of-life questionnaires for the visually impaired were refined by a multi-professional group and visually impaired focus groups. The resulting 76 items were completed by 293 visually impaired patients with stable vision on two occasions separated by a month. The faVIQ scores of 75 patients with no ocular pathology were compared to 75 age and gender matched patients with visual impairment. Rasch analysis reduced the faVIQ items to 27. Correlation to standard visual metrics was moderate (r=0.32-0.46) and to the NEI-VFQ was 0.48. The faVIQ was able to clearly discriminate between age and gender matched populations with no ocular pathology and visual impairment with an index of 0.983 and 95% sensitivity and 95% specificity using a cut off of 29. The faVIQ allows sensitive assessment of quality-of-life in the visually impaired and should support studies which evaluate the effectiveness of low vision rehabilitation services.

  2. FaSD-somatic: a fast and accurate somatic SNV detection algorithm for cancer genome sequencing data.

    Science.gov (United States)

    Wang, Weixin; Wang, Panwen; Xu, Feng; Luo, Ruibang; Wong, Maria Pik; Lam, Tak-Wah; Wang, Junwen

    2014-09-01

    Recent advances in high-throughput sequencing technologies have enabled us to sequence large number of cancer samples to reveal novel insights into oncogenetic mechanisms. However, the presence of intratumoral heterogeneity, normal cell contamination and insufficient sequencing depth, together pose a challenge for detecting somatic mutations. Here we propose a fast and an accurate somatic single-nucleotide variations (SNVs) detection program, FaSD-somatic. The performance of FaSD-somatic is extensively assessed on various types of cancer against several state-of-the-art somatic SNV detection programs. Benchmarked by somatic SNVs from either existing databases or de novo higher-depth sequencing data, FaSD-somatic has the best overall performance. Furthermore, FaSD-somatic is efficient, it finishes somatic SNV calling within 14 h on 50X whole genome sequencing data in paired samples. The program, datasets and supplementary files are available at http://jjwanglab.org/FaSD-somatic/. Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  3. Formal language of Lanna Shop House’s Façade in Lampang Old city, Thailand

    Science.gov (United States)

    Phetsuriya, Natthakit

    2017-10-01

    This article aims to presents ‘the formal architectural language of Lanna Designs” that is a linguistic paradigm for decrypt the linguistic system which is hidden in the Lanna façade style. Lanna Designs present an identity of vital ordered and crucial articulated formal language which inherently set of mathematical rules for the arrangement of ornaments. The scope of this article is attempted to the morphology of façades of the ten shop houses which located in Lampang Old city and have familiar proportion and style. In this article, the sampling of façade buildings required proportion as three-stall and two-story with familiar style. The morphology is described based on terms of a symbolic encoding system that is represented as graphically building grammar. The system helps to emphasize commonalities in façade languages and propose a prototype of identified Lanna façade design. This methodology might be the option for decrypt or study in every facades style.

  4. Experimental study of DNB on the WWER FA model with mixing grids with MCP disconnection

    International Nuclear Information System (INIS)

    Pomet'ko, R.S.; Smirnov, A.M.; Vasil'chenko, I.N.; V'yalitsyn, V.V.; Galkin, I.Yu.; Volkov, S.E.

    2015-01-01

    Prepared for unsteady experimental research is the 19-rod model FA WWER-1200 with a heated length of 3.73 m with uniform heat release across the section. Along with standard spacing gratings, the model is equipped with two intermediate lattices-intensifiers of the“vortex” type and two-type “sweep”. Experimental studies of the heat transfer crisis were carried out in the worst case, involving the shutdown of all the working MCPs. It is found that in the nonstationary regimes studied, with a decrease in the flow rate, the critical heat flux is 4% higher than in steady-state regimes with the same parameters (flow rate, pressure, inlet temperature). Thus, the correlation for stationary regimes is conservative in the calculation of reserves before the crisis when the MCP is shut off [ru

  5. Comparative analysis of façade regulations in the Nordic countries

    Directory of Open Access Journals (Sweden)

    Strömgren Michael

    2013-11-01

    Full Text Available This paper presents a comparison of Nordic fire safety requirements of facades. A reference building was chosen as a four-story residential building. The requirements were analysed with focus on what fire safety objectives they represent, and what type of pre-accepted solutions that were used. The results reveal large differences in the Nordic building regulations concerning façades. The differences occur both with regards to performance objectives, criteria and acceptable solutions. Current European methods are not sufficient to characterise the requirements needed for fire safety of facades. There is a need to develop new common verification methods, as well as better data and research, to improve requirements and to reach conformity.

  6. First International Workshop on Human Factors in Modeling (HuFaMo 2015)

    DEFF Research Database (Denmark)

    Störrle, Harald; Chaudron, Michel R. V.; Amaral, Vasco

    2015-01-01

    human factors in modeling. Our goal is to improve the state of the science and professionalism in empirical research in the Model Based Engineering community. Typical examples of research questions might consider the usability of a certain approach, such as a method or language, or the emotional states...... and systematic approaches to assert usability in modeling and confirm the claims of productivity. This workshop creates a space for discussion being a get together of both MDE, Usability, Human Interfaces and the Experimental Software engineering community. HuFaMo expressly focuses on human factors, in order...... to raise the awareness for these topics and the associated research methods and questions in the modeling community, providing an outlet for research of this type, guaranteeing high quality reviews by people that apply these research methods themselves. Along with fully complete empirical evaluations...

  7. SPOTLIGHTING ENGLISH PHRASAL VERBS

    Directory of Open Access Journals (Sweden)

    Éva Kovács

    2014-03-01

    Full Text Available Phrasal verbs or multi-word verbs, such as call off, go into and run up against, etc. represent a very interesting and challenging aspect of the English language. In ELT there is a widespread view that familiarity with a wide range of phrasal verbs and the ability to use them appropriately in context are among the distinguishing marks of a native-like command of English. However, it is also generally recognised that these verb+particle combinations pose special difficulties for both learners and teachers of English partly because there are so many of them, partly because they have special semantic, syntactic and stylistic properties. Besides, quite many of them can be used as nouns, e.g. a hideaway, a stowaway and a write-off, etc. and adjectives, e.g. a broken-down car and a knockdown price, etc. What is more, again quite many of them have a single word equivalent of Romance origin, which, however, often differs from them in terms of style, collocation and meaning, e.g. blow up ~ explode, do away with ~ eliminate and put out ~ extinguish, etc. Furthermore, it is a misconception that phrasal verbs are mainly used in informal style and in spoken English. In fact, they can be found in many styles of writing, ranging from highly formal texts to slang, e.g. call forth vs. gobble up, etc. This paper sets out to explore the unique and complex nature of English verb+particle constructions in order to make them a more manageable part of the vocabulary of English.

  8. Rapid evaluation and quality control of next generation sequencing data with FaQCs.

    Science.gov (United States)

    Lo, Chien-Chi; Chain, Patrick S G

    2014-11-19

    Next generation sequencing (NGS) technologies that parallelize the sequencing process and produce thousands to millions, or even hundreds of millions of sequences in a single sequencing run, have revolutionized genomic and genetic research. Because of the vagaries of any platform's sequencing chemistry, the experimental processing, machine failure, and so on, the quality of sequencing reads is never perfect, and often declines as the read is extended. These errors invariably affect downstream analysis/application and should therefore be identified early on to mitigate any unforeseen effects. Here we present a novel FastQ Quality Control Software (FaQCs) that can rapidly process large volumes of data, and which improves upon previous solutions to monitor the quality and remove poor quality data from sequencing runs. Both the speed of processing and the memory footprint of storing all required information have been optimized via algorithmic and parallel processing solutions. The trimmed output compared side-by-side with the original data is part of the automated PDF output. We show how this tool can help data analysis by providing a few examples, including an increased percentage of reads recruited to references, improved single nucleotide polymorphism identification as well as de novo sequence assembly metrics. FaQCs combines several features of currently available applications into a single, user-friendly process, and includes additional unique capabilities such as filtering the PhiX control sequences, conversion of FASTQ formats, and multi-threading. The original data and trimmed summaries are reported within a variety of graphics and reports, providing a simple way to do data quality control and assurance.

  9. Higher English for CFE

    CERN Document Server

    Bridges, Ann; Mitchell, John

    2015-01-01

    A brand new edition of the former Higher English: Close Reading , completely revised and updated for the new Higher element (Reading for Understanding, Analysis and Evaluation) - worth 30% of marks in the final exam!. We are working with SQA to secure endorsement for this title. Written by two highly experienced authors this book shows you how to practice for the Reading for Understanding, Analysis and Evaluation section of the new Higher English exam. This book introduces the terms and concepts that lie behind success and offers guidance on the interpretation of questions and targeting answer

  10. Gimson's pronunciation of English

    CERN Document Server

    Cruttenden, Alan

    2014-01-01

    Since its first publication in 1962, Gimson's Pronunciation of English has been the essential reference book for anyone studying or teaching the pronunciation of English.This eighth edition has been updated to describe General British (GB) as the principal accent, rather than RP, and the accompanying transcriptions have been brought into line with recent changes in pronunciation. This latest edition also includes completely rewritten chapters on the history of the language and the emergence of a standard, alongside a justification for the change from RP to GB.

  11. Telephoning in English

    CERN Document Server

    Naterop, B Jean

    1994-01-01

    Many people have to use English on the telephone in the course of their work, either at the level of taking a simple message or involving more complex tasks such as requesting information. Telephoning in English provides an up-to-date and relevant context in which students from lower-intermediate level upwards can develop practical telephone skills. The course principally develops spoken interactive skills, but also includes reading material on telephone systems and techniques. As the material is not restricted to particular job functions, it is suitable for students in a wide range of business and administration fields.

  12. The Effect of Promotional Tools on Conveying Brand Identity from Sport Consumers’ Viewpoint in the Country’s Premier League

    Directory of Open Access Journals (Sweden)

    Ehsan Asadollahi

    2017-10-01

    Full Text Available The economic environment and business, advertising in sport is one of the ways that most companies to manage the brand, its products and expanding its market in the country. The aim of the present study investigates the effects of advertising on transfer of brand identity from the perspective of sports consumers in Premier League football. This study on the nature and purpose and in terms of descriptive and correlational in terms of search data, a survey was carried out that way. After face and content validity, reliability test using Cronbach's alpha for the questionnaire, the effect of advertising tools 0.89, questionnaire transfer brand identity was 0.86, respectively. In order to analyze the data, descriptive and inferential statistical methods for the calculation and processing information, and also Spss software packages and LISREL were used. The study findings also confirmed the emergence of structural equation and the findings of other researchers, showed a promotional tool to transfer of brand identity from the perspective of the Sports consumer was significant effect (Chi-Square/df=2/04, RMSEA=0/059, P-Value =0/0001. The effect of each variable prioritize research also showed use of tool television advertising has the greatest impact on consumers transfer of brand identity. According to the results, it can be said that managers, marketers and planners of advertising companies, organizations and clubs and sporting goods service provider using of the effectiveness of each advertising tool and provide an integrated program of tools and to inform, remind and convince consumers can transfer of brand identity or brand and achieve their advertising goals.

  13. Le premier partenariat public-privé pour l’irrigation au Maroc : durable pour tous ?

    Directory of Open Access Journals (Sweden)

    Houdret Annabelle

    2016-03-01

    Full Text Available Les partenariats public-privé (PPP sont un phénomène relativement récent dans le secteur de l’irrigation ; le projet El Guerdane au Maroc est ainsi le premier de son genre. Inauguré en 2008, le projet alimente en eau 10 000 ha de plantations d’agrumes. Les banques internationales de développement le présentent comme un succès, mais l’impact sur le développement local est, au mieux, mitigé. Alors que certains agriculteurs ont bénéficié de cette initiative, d’autres ont été marginalisés, en termes d’accès à l’eau, aux terres fertiles et au développement. Fondé sur des recherches de terrain extensives conduites entre 2005 et 2013, l’article révèle trois problèmes cruciaux du projet PPP : des effets souvent négatifs sur les revenus des acteurs et sur le développement ; un partage inégal des coûts, des bénéfices et des risques entre les secteurs public et privé ; un impact environnemental incertain. Sur la base de ces résultats, l’étude situe le projet dans le contexte plus large de l’évolution des rapports de force politico-économiques au Maroc.

  14. Association of a reduction in central obesity and phosphorus intake with changes in urinary albumin excretion: the PREMIER study.

    Science.gov (United States)

    Chang, Alex; Batch, Bryan C; McGuire, Heather L; Vollmer, William M; Svetkey, Laura P; Tyson, Crystal C; Sanguankeo, Anawin; Anderson, Cheryl; Houston, Jessica; Appel, Lawrence J

    2013-11-01

    Excess adiposity and dietary factors may be important determinants of urinary albumin excretion (UAE). Observational analysis of PREMIER, a randomized trial designed to lower blood pressure using behavioral interventions (counseling on weight loss, healthy diet, and exercise). 481 participants with normal kidney function who provided adequate 24-hour urine collections at baseline and 6 months. Change in waist circumference; 24-hour urine sodium, potassium, and phosphorus excretion; and protein intake estimated from urea nitrogen. The primary outcome was change in log-transformed 24-hour UAE over 6 months. After 6 months, the proportion of individuals with UAE ≥10 mg/d decreased from 18.7% to 12.7% (P phosphorus (-27.7 ± 314.1 mg/d), and protein intake (-1.7 ± 19.4 g/d) were observed. After adjustment for relevant covariates, the following variables were associated significantly with reduction in ln(UAE) in separate models: decrease in waist circumference (P = 0.001), decrease in 24-hour urine phosphorus excretion (P urine phosphorus excretion (P = 0.03), but not change in protein intake (P = 0.5), remained associated significantly with reduction in ln(UAE). These associations remained significant even after adjustment for changes in blood pressure and insulin resistance. Baseline UAE and metabolic syndrome modified the relationship of waist circumference with ln(UAE); specifically, individuals with higher UAE and baseline metabolic syndrome experienced greater reductions in ln(UAE) from decreases in waist circumference. Observational study with potential for confounding. In adults with normal kidney function, decreases in waist circumference and 24-hour urine phosphorus excretion are associated with reductions in UAE. These findings support the rationale for clinical trials to determine whether reducing dietary phosphorus intake or waist circumference could prevent chronic kidney disease or slow its progression. Copyright © 2013 National Kidney Foundation, Inc

  15. Analysis of Diagnoses Associated with Multiple Sclerosis-Related In-Hospital Mortality Using the Premier Hospital Database.

    Science.gov (United States)

    Ernst, Frank R; Pocoski, Jennifer; Cutter, Gary; Kaufman, David W; Pleimes, Dirk

    2016-01-01

    We sought to compare mortality rates and related diagnoses in hospitalized patients with multiple sclerosis (MS), those with diabetes mellitus (DM), and the general hospitalized population (GHP). Patients who died between 2007 and 2011 were identified in the US hospital-based Premier Healthcare Database. Demographic information was collected, mortality rates calculated, and principal diagnoses categorized. Of 55,152 unique patients with MS identified, 1518 died. Mean age at death was 10 years younger for the MS group (63.4 years) than for the DM (73.3 years) and GHP (73.1 years) groups. Age-adjusted mortality rates, based on the 2000 US Standard Million Population, were 1077, 1248, and 1133 per 100,000, respectively. Infection was the most common principal diagnosis at the hospital stay during which the patient died in the MS cohort (43.1% vs. 26.3% and 24.0% in the DM and GHP groups, respectively). Other common principal diagnoses in the MS group included pulmonary (17.5%) and cardiovascular (12.1%) disease. Septicemia/sepsis/septic shock was a secondary diagnosis for 50.7% of patients with MS versus 36.0% and 31.0% of patients in the DM and GHP cohorts, respectively. Patients with MS had a shorter life span than patients with DM or the GHP and were more likely to have a principal diagnosis of infection at their final hospital stay. However, the database was limited to codes recorded in the hospital; diagnoses received outside the hospital were not captured.

  16. Importance of English and Different Methods of Teaching English

    OpenAIRE

    Reddy, Dr. P. Sreenivasulu

    2013-01-01

    Todays world considers English as a global language. The present article explains how the teaching of English started with Grammar-Translation Method and secured a strong hold in the field of teaching English, though its basic assumptions were questionable. It also examines the principles of Direct Method and its insistence on establishing a bond between the experience and expression. In an effort to meet the needs of the Indian students of English, we learn that Michael West proposed the Rea...

  17. Teaching English to Engineers: Between English Language Teaching and Psychology

    OpenAIRE

    Irina-Ana Drobot

    2016-01-01

    Teaching English to Engineers is part of English for Specific Purposes, a domain which is under the attention of English students especially under the current conditions of finding jobs and establishing partnerships outside Romania. The paper will analyse the existing textbooks together with the teaching strategies they adopt. Teaching English to Engineering students can intersect with domains such as psychology and cultural studies in order to teach them efficiently. Textbooks for students o...

  18. English Verb Accuracy of Bilingual Cantonese-English Preschoolers.

    Science.gov (United States)

    Rezzonico, Stefano; Goldberg, Ahuva; Milburn, Trelani; Belletti, Adriana; Girolametto, Luigi

    2017-07-26

    Knowledge of verb development in typically developing bilingual preschoolers may inform clinicians about verb accuracy rates during the 1st 2 years of English instruction. This study aimed to investigate tensed verb accuracy in 2 assessment contexts in 4- and 5-year-old Cantonese-English bilingual preschoolers. The sample included 47 Cantonese-English bilinguals enrolled in English preschools. Half of the children were in their 1st 4 months of English language exposure, and half had completed 1 year and 4 months of exposure to English. Data were obtained from the Test of Early Grammatical Impairment (Rice & Wexler, 2001) and from a narrative generated in English. By the 2nd year of formal exposure to English, children in the present study approximated 33% accuracy of tensed verbs in a formal testing context versus 61% in a narrative context. The use of the English verb BE approximated mastery. Predictors of English third-person singular verb accuracy were task, grade, English expressive vocabulary, and lemma frequency. Verb tense accuracy was low across both groups, but a precocious mastery of BE was observed. The results of the present study suggest that speech-language pathologists may consider, in addition to an elicitation task, evaluating the use of verbs during narratives in bilingual Cantonese-English bilingual children.

  19. Practices That Promote English Reading for English Learners (Els)

    Science.gov (United States)

    Martínez, Rebecca S.; Harris, Bryn; McClain, Maryellen Brunson

    2014-01-01

    Schools are becoming increasingly diversified; however, training and professional development related to working with English language learners (ELs), especially in the area of English reading, is limited. In this article, we identify three "Big Ideas" of effective and collaborative practices that promote English reading achievement for…

  20. Japanese College Students' Attitudes towards Japan English and American English

    Science.gov (United States)

    Sasayama, Shoko

    2013-01-01

    This study investigated contemporary Japanese college students' attitudes towards Japan English (JE) and American English (AE) through a verbal guise test (VGT) as well as a questionnaire. Forty-four Japanese college students listened to four Japanese and four North Americans reading a text in English, rated them in terms of solidarity-related…

  1. Why Do Primary School English Teachers Decide to Teach English?

    Science.gov (United States)

    Amengual-Pizarro, Marian; Garcia Laborda, Jesus

    2015-01-01

    This study is an attempt to explore the nature of L2 teachers' motivation towards English language learning and their decision to become English teachers. A total of 45 third-year prospective Primary school English teachers at the University of the Balearic Islands completed a small-scale survey adapted from Gardner's Attitude/Motivation Test…

  2. World Englishes, English as an International Language and Applied Linguistics

    Science.gov (United States)

    Kilickaya, Ferit

    2009-01-01

    The paper discusses World Englishes (WEs) in relation to English as an International Language (EIL) and Applied Linguistics. Taking into account Kachru's interesting but at the same time controversial debate about the status of English in its varieties, which are commonly called WEs and the opposing ideas presented by Quirk, it is aimed to present…

  3. On Differences between General English Teaching and Business English Teaching

    Science.gov (United States)

    Zhu, Wenzhong; Liao, Fang

    2008-01-01

    With the accelerating rate of globalization, business exchanges are carried out cross the border, as a result there is a growing demand for talents professional both in English and Business. We can see that at present Business English courses are offered by many language schools in the aim of meeting the need for Business English talent. Many…

  4. English II. Revised.

    Science.gov (United States)

    Spann, Margaret; And Others

    This manual is intended to enable academically disadvantaged and disabled youth to acquire basic communications and English skills while also acquiring a salable vocational skill. The following topics are covered in the individual units: related vocational information (abbreviations); related vocational skills (job search, job application forms,…

  5. HAIKU IN ENGLISH.

    Science.gov (United States)

    HENDERSON, HAROLD G.

    CONVENTIONS FOR CLASSICAL JAPANESE HAIKU USUALLY INCLUDE--17 JAPANESE SYLLABLES IN A 5-7-5 LINE PATTERN, AND SOME SPECIFIC REFERENCE TO AN ASPECT OF NATURE AND TO A PARTICULAR EVENT, PRESENTED AS IF IT WERE HAPPENING IN THE IMMEDIATE PRESENT TO ALLOW THE READER TO EXPERIENCE THE POET'S EMOTION. HAIKU IN ENGLISH, A FORM OF POETRY WHICH HAS BECOME…

  6. Choosing Tense in English.

    Science.gov (United States)

    1984-11-01

    Halliday) have emphasized deixis as a temporal as well as a spatial category. Halliday’s account of tense is the foundation for the present account...Longman, 1981. [Huddleston 69] Huddleston, R. Some Observations on Tense and Deixis in English. Language 45:777 - 806, 1969. [Hudson 76] Hudson, R. A

  7. English 3135: Visual Rhetoric

    Science.gov (United States)

    Gatta, Oriana

    2013-01-01

    As an advanced rhetoric and composition doctoral student, I taught Engl 3135: Visual Rhetoric, a three-credit upper-level course offered by the Department of English at Georgia State University. Mary E. Hocks originally designed this course in 2000 to, in her words, "introduce visual information design theories and practices for writers [and]…

  8. Dictionaries of Canadian English

    African Journals Online (AJOL)

    Information Technology

    John Considine, Department of English, University of Alberta,. Edmonton, Canada .... this sort of negative attention to it. Wordlists appeared sporadically, but on a very modest scale. So, for instance, Julian Moreton's Life and Work in Newfound- ..... sort of scale as the Dictionary of Americanisms on which Lovell had worked.

  9. English Leadership Quarterly, 1993.

    Science.gov (United States)

    Strickland, James, Ed.

    1993-01-01

    These four issues of the English Leadership Quarterly represent those published during 1993. Articles in number 1 deal with parent involvement and participation, and include: "Opening the Doors to Open House" (Jolene A. Borgese); "Parent/Teacher Conferences: Avoiding the Collision Course" (Robert Perrin); "Expanding Human…

  10. English-Cinyanja Dictionary.

    Science.gov (United States)

    Zambesi Mission, Mitsidi (Malawi).

    This English-Chinyanja (Cinyanja) dictionary was prepared and published by the Zambesi Mission for use in Africa. Compilers of this volume were aided by Africans of Southern Angoniland and a Yao tribesman from the Blantyre district knowledgeable in Chinyanja. Spelling rules used are those of the United Translation Board, which has adopted…

  11. Oxford English Dictionary

    African Journals Online (AJOL)

    and supremacist attitudes, which caused entries for words of this kind to be shorter and less detailed, and affected ... kinds should receive the same degree of attention, which implies that data collection from the reading of primary ... this paper, African languages have contributed a great many vocabulary items to the English ...

  12. Overcoming Fossilized English.

    Science.gov (United States)

    Graham, Janet G.

    Causes of language fossilization and ways to overcome it are considered. Fossilization is the relatively permanent incorporation of incorrect linguistic forms into a person's second language competence. The discussion is focused on fossilization of incorrect syntactical rules, based on experiences with learners of English as a second language at…

  13. Fostering English Learners' Confidence

    Science.gov (United States)

    Bondie, Rhonda; Gaughran, Laurie; Zusho, Akane

    2014-01-01

    A teacher is doing something right when his high school students--kids with limited English, no less--form groups and begin discussing a lesson on quadratic equations at the start of class, without any teacher direction. Bondie, Gaughran, and Zusho describe "discussion routines" that teachers at International Community High School in the…

  14. English Only JAMAS.

    Science.gov (United States)

    Cartagena, Juan

    1989-01-01

    Puerto Ricans have been largely ignored in the current debate over English as a national language. Once the rhetoric of language restrictionists is discarded, the real issue becomes that of the political empowerment of Puerto Ricans. The history of language policy in relation to Puerto Ricans is also reviewed. (SLD)

  15. English in Africa

    African Journals Online (AJOL)

    English in Africa is listed in the Journal of Commonwealth Literature Annual Bibliography, the Modern Language Association MLA International Bibliography, Institute for Scientific Information Arts and Humanities Citation Index, and accredited by the South African Department of Education. The journal has its own website at.

  16. Measuring Growth in English.

    Science.gov (United States)

    Diederich, Paul B.

    The monograph is a complete outline for a program designed to help English departments institute logical and fair procedures for grading student essays. The contents in this monograph include "Factors in Judgments of Writing Ability,""The Effect of Bias,""Measuring Improvement in Writing,""Personal vs Staff Grading,""Standard Scores for Test…

  17. Systems of Vegetal Façade and Green Roofs used as a Sustainable Option in Architecture

    OpenAIRE

    Chanampa, Mariana; Vidal Rivas, Pilar; Alonso Ojembarrena, Javier; Olivieri, Francesca

    2010-01-01

    Green architecture contributes not only in reducing the building’s thermal loads but also in reducing the effects of the urban heat island in densely built-up areas in a hardly natural environment. The current green systems are built in situ/on site and are very expensive, hence the need to create industrialized prevegetated systems which improve the buildings’ energy savings and reduce the times of construction works. The present paper describes three green systems for façades (gabion façade...

  18. English Language Teaching Through Literature : An Application of English Poetry in the High School English Textbook to the Classroom

    OpenAIRE

    濵口, 脩

    2004-01-01

    The aim of this present paper is to review the present state of English poetry in the high school English textbooks in Japan and to propose some practical application of English poems to the English language classroom. Several cases in which English poems are found in actual English high school textbooks are discussed, and then, since there seems to be no explanation of teaching English poems, with some notes of them and of reading English poems in general, some practical suggetions for impro...

  19. Standard English and Language Attitudes

    OpenAIRE

    ソランキ, ネイディン

    2005-01-01

    This paper investigates the attitudes and opinions surrounding Standard English (SE) within the United Kingdom. The definition of SE, for the purposes of this study, is standard grammar and standard pronunciation of southern English, commonly referred to as 'BBC English'. The subject of SE and attitudes towards different accents and dialects of British English is emotive and attracts strong opinions. The main issues discussed here are the place of language in society, the social implications ...

  20. Symposium: What Is College English?

    Science.gov (United States)

    Bloom, Lynn Z.; White, Edward M.; Enoch, Jessica; Hawk, Byron

    2013-01-01

    This symposium explores the role(s) College English has (or has not) had in the scholarly work of four scholars. Lynn Bloom explores the many ways College English influenced her work and the work of others throughout their scholarly lives. Edward M. White examines four articles he has published in College English and draws connections between…

  1. Brunei English: A Developing Variety

    Science.gov (United States)

    O'Hara-Davies, Breda

    2010-01-01

    A considerable amount of time has elapsed since the existence of a distinct variety of English, Brunei English (BNE), was mooted in the early 1990s. A subsequent study conducted by Svalberg in 1998 suggested that BNE was then in its infancy and that its speakers were largely unaware of the differences between it and Standard British English (STE).…

  2. Prescriptivism, Creativity, and World Englishes.

    Science.gov (United States)

    Bhatt, Rakesh M.

    1995-01-01

    Critiques the idea that standard British or American English is the only model for second language instruction, arguing that successful English language teaching in nonnative contexts, such as in India, must address the relationship between the forms that English manifests and its speakers' perception of reality and the nature of their cultural…

  3. The Zanzibar English Reading Programme.

    Science.gov (United States)

    Cunningham, Roger.

    1991-01-01

    The Zanzibar Ministry of Education instituted an English reading program into all secondary schools in 1989 to raise the levels of English teaching and learning (English being the medium of instruction and testing from secondary level and beyond). The program description and conclusions include implications for program design and implementation.…

  4. Chinese English Learners' Strategic Competence

    Science.gov (United States)

    Wang, Dianjian; Lai, Hongling; Leslie, Michael

    2015-01-01

    The present study aims to investigate Chinese English learners' ability to use communication strategies (CSs). The subjects are put in a relatively real English referential communication setting and the analyses of the research data show that Chinese English learners, when encountering problems in foreign language (FL) communication, are…

  5. English as an African Language.

    Science.gov (United States)

    Desai, Gaurav

    1993-01-01

    Discusses the role of the English language in postcolonial African literature, focusing on the politics of language, "Africanized" English, and the social languages used in Chinua Achebe's novels and concludes that English today is as much an African language as a British or American one. (Contains 37 references.) (MDM)

  6. Teachers' Habitus for Teaching English

    Science.gov (United States)

    Flynn, Naomi

    2015-01-01

    In this examination of monolingual and multilingual pedagogies I draw on literature that explores the position of English globally and in the curriculum for English. I amplify the discussion with data from a project exploring how teachers responded to the arrival of Polish children in their English classrooms following Poland's entry to the…

  7. English Language Teaching Profile: Cameroon.

    Science.gov (United States)

    British Council, London (England). English-Teaching Information Centre.

    This is a summary in outline form of the English language teaching situation in Cameroon. Cameroon is officially a French/English bilingual state but English at present plays the minor part. There are five francophone and two anglophone provinces with populations of five million and one and a half million respectively. In the anglophone provinces…

  8. Intercultural Processes in Accented English

    Science.gov (United States)

    Rivers, Damian J.

    2011-01-01

    This study assessed the attitudinal responses of 48 Japanese university students towards 10 accented English speech samples across nine evaluative criteria. Of the 10 samples, one was a Japanese-English speech sample (the intracultural familiar), seven were non-native-English samples originating from a variety of Asian countries (intercultural…

  9. The Passive in Singapore English.

    Science.gov (United States)

    Bao, Zhiming; Wee, Lionel

    1999-01-01

    Presents an analysis of the two passive (or passive-like) constructions in Singapore English which exhibit substrate influence from Malay and Chinese. The paper shows that while substrate languages contribute to the grammar of Singapore English, the continued prestige of standard English exerts normative pressure and mitigates the effect of…

  10. Correct English for Modern Needs.

    Science.gov (United States)

    Pooley, Robert C.

    1995-01-01

    Reprints an article originally published in 1932. Discusses the development of S. Leonard's book "Current English Usage." Suggests that the monograph stands as a symbol of a spirit and attitude in the teaching of English which will have far-reaching influence in determining the course of study and content of English instruction in the future. (RS)

  11. The cleaner, the greener? Product sustainability assessment of the biomimetic façade paint Lotusan® in comparison to the conventional façade paint Jumbosil®

    Directory of Open Access Journals (Sweden)

    Florian Antony

    2016-12-01

    Full Text Available Background: The debate on the question whether biomimetics has a specific potential to contribute to sustainability is discussed among scientists, business leaders, politicians and those responsible for project funding. The objective of this paper is to contribute to this controversial debate by presenting the sustainability assessment of one of the most well-known and most successful biomimetic products: the façade paint Lotusan®.Results: As a first step it has been examined and verified that the façade paint Lotusan® is correctly defined as a biomimetic product. Secondly, Lotusan® has been assessed and compared to a conventional façade paint within the course of a detailed product sustainability assessment (PROSA. For purposes of comparison, the façade paint Jumbosil® was chosen as reference for a conventional paint available on the market. The benefit analysis showed that both paints fulfil equally well the requirements of functional utility. With respect to the symbolic utility, Lotusan® has a particular added aesthetic value by the preservation of the optical quality over the life cycle. Within the social analysis no substantial differences between the two paints could be found regarding the handling and disposal of the final products. Regarding the life-cycle cost, Lotusan® is the more expensive product. However, the higher investment cost for a Lotusan®-based façade painting are more than compensated by the longer life time, resulting in both reduced overall material demand and lower labour cost. In terms of the life-cycle impact assessment, it can be ascertained that substantial differences between the paints arise from the respective service life, which are presented in terms of four scenario analyses.Conclusion: In summary, the biomimetic façade paint Lotusan® has been identified as a cost-effective and at the same time resource-saving product. Based on the underlying data and assumptions it could be demonstrated that

  12. Evaluation of Carbohydrate-Derived Fulvic Acid (CHD-FA) as a Topical Broad-Spectrum Antimicrobial for Drug-Resistant Wound Infections

    Science.gov (United States)

    2014-10-01

    resistant bacteria and fungi was completed. The minimum inhibitory concentrations (MIC50 and MIC90) for CDH -FA against a collection of over 600...efficacy of topical application of CDH -FA on small animal models of wound infection with a wide variety of bacterial and fungal pathogens. Approach...Establish minimum inhibitory concentrations (MIC50 and MIC90) for CDH -FA against large collections of clinical isolates representing wound-associated

  13. Environmental and health effects of nanomaterials in nanotextiles and façade coatings.

    Science.gov (United States)

    Som, Claudia; Wick, Peter; Krug, Harald; Nowack, Bernd

    2011-08-01

    Engineered nanomaterials (ENM) are expected to hold considerable potential for products that offer improved or novel functionalities. For example, nanotechnologies could open the way for the use of textile products outside their traditional fields of applications, for example, in the construction, medical, automobile, environmental and safety technology sectors. Consequently, nanotextiles could become ubiquitous in industrial and consumer products in future. Another ubiquitous field of application for ENM is façade coatings. The environment and human health could be affected by unintended release of ENM from these products. The product life cycle and the product design determine the various environmental and health exposure situations. For example, ENM unintentionally released from geotextiles will probably end up in soils, whereas ENM unintentionally released from T-shirts may come into direct contact with humans and end up in wastewater. In this paper we have assessed the state of the art of ENM effects on the environment and human health on the basis of selected environmental and nanotoxicological studies and on our own environmental exposure modeling studies. Here, we focused on ENM that are already applied or may be applied in future to textile products and façade coatings. These ENM's are mainly nanosilver (nano-Ag), nano titanium dioxide (nano-TiO(2)), nano silica (nano-SiO(2)), nano zinc oxide (nano-ZnO), nano alumina (nano-Al(2)O(3)), layered silica (e.g. montmorillonite, Al(2)[(OH)(2)/Si(4)O(10)]nH(2)O), carbon black, and carbon nanotubes (CNT). Knowing full well that innovators have to take decisions today, we have presented some criteria that should be useful in systematically analyzing and interpreting the state of the art on the effects of ENM. For the environment we established the following criteria: (1) the indication for hazardous effects, (2) dissolution in water increases/decreases toxic effects, (3) tendency for agglomeration or sedimentation

  14. Le premier examen gynécologique idéal imaginé par les jeunes filles

    Science.gov (United States)

    Freyens, Anne; Dejeanne, Mélanie; Fabre, Elise; Rouge-Bugat, Marie-Eve; Oustric, Stéphane

    2017-01-01

    Résumé Objectif Explorer les représentations sur l’examen gynécologique (EG) et identifier les critères nécessaires à son bon déroulement chez des adolescentes n’ayant pas encore vécu cet examen. Type d’étude Enquête qualitative par entrevues semi-dirigées. Contexte Midi-Pyrénées (France) et Auvergne (France). Participants Jeunes filles de 15 à 19 ans qui n’ayant pas vécu l’EG. Méthodes Le mode de recrutement de l’échantillon a été double : sélection des jeunes filles par la technique boule-de-neige et sélection par la technique d’échantillonnage ciblé jusqu’à l’obtention de la saturation des données tout en cherchant la variation maximale dans les profils des sujets. Les questions ouvertes portaient sur les sources d’informations, les connaissances, les critères de bon déroulement et l’imaginaire autour de l’EG. Le verbatim a fait l’objet d’une analyse longitudinale immédiate rassemblant le contexte (notes des chercheurs) et les idées principales de l’entretien. Une analyse transversale thématique a été réalisée. Principales constatations Une méconnaissance générale des jeunes filles sur l’EG entretenait l’imaginaire autour de cet examen perçu comme obligatoire. L’EG idéal, selon les jeunes filles interrogées, aurait lieu chez une jeune fille qui se sentirait prête, informée préalablement, pouvant être accompagnée selon son souhait. Cet examen se déroulerait dans un environnement chaleureux et confortable afin de diminuer le sentiment de vulnérabilité. La qualité du lien avec le médecin conditionnerait l’acceptation de cet examen par les jeunes filles. Conclusion Une consultation dédiée à l’information, préalable à la consultation où a lieu l’EG, permettrait de diminuer les appréhensions, d’améliorer les connaissances des jeunes filles et de favoriser le bon déroulement du futur premier EG tant pour le médecin que pour la patiente. PMID:28807971

  15. Attitudes towards English in Ghana

    Directory of Open Access Journals (Sweden)

    Kari Dako

    2017-05-01

    Full Text Available The paper considers official and individual attitudes towards bilingualism in English and a Ghanaian language. We ask whether bilingualism in English and Ghanaian languages is a social handicap, without merit, or an important indicator of ethnic identity. Ghana has about 50 non-mutually intelligible languages, yet there are no statistics on who speaks what language(s where in the country. We consider attitudes to English against the current Ghanaian language policy in education as practised in the school system. Our data reveal that parents believe early exposure to English enhances academic performance; English is therefore becoming the language of the home.

  16. Reconsidering English Grammar Teaching for Improving Non-English Majors' English Writing Ability

    Science.gov (United States)

    Shen, Yuru

    2012-01-01

    With the globalization of world economy, English learners' writing ability has been attached less and less importance. As a result, many college students in China, especially the non-English majors, cannot express themselves effectively in written English. They make various kinds of mistakes, mostly grammar mistakes, such as writing sentence…

  17. [Risk of nasopharyngeal cancer, Leukemia and other tumors in a cohort of employees and students potentially exposed to (FA) formaldehyde in University laboratories].

    Science.gov (United States)

    Sernia, S; Di Folco, F; Altrudo, P; Sbriccoli, B; Sestili, C; Colamesta, V; Del Buono, S; Michetti, A; Ortis, M; Dawodu, A; Villari, P; La Torre, G

    2016-01-01

    FA was recently classified as carcinogen of second class (category 1B). A retrospective cohort study was conducted for the evaluation of the association between exposure to FA and cancer in professionally potentially exposed in a University setting. The cohort was composed of 140 exposed to FA and 364 not exposed in the period 1999-2015. The results showed no cancers of naso-pharynx and leukemias or lymphomas both among exposed and not exposed. Moreover, the exposure to FA is not significantly associated to an increase of other types of tumors.

  18. Dlk1/FA1 is a novel endocrine regulator of bone and fat mass and its serum level is modulated by growth hormone

    DEFF Research Database (Denmark)

    Abdallah, Basem M.; Ding, Ming; Jensen, Charlotte H.

    2007-01-01

    Fat and bone metabolism are two linked processes regulated by several hormonal factors. Fetal antigen 1 (FA1) is the soluble form of dlk1 (delta-like 1), which is a member of the Notch-Delta family. We previously identified FA1 as a negative regulator of bone marrow mesenchymal stem cell...... differentiation. Here, we studied the effects of circulating FA1 on fat and bone mass in vivo by generating mice expressing high serum levels of FA1 (FA1 mice) using the hydrodynamic-based gene transfer procedure. We found that increased serum FA1 levels led to a significant reduction in total body weight, fat...... mass, and bone mass in a dose-dependent manner. Reduced bone mass in FA1 mice was associated with the inhibition of mineral apposition rate and bone formation rates by 58 and 72%, respectively. Because FA1 is colocalized with GH in the pituitary gland, we explored the possible modulation of serum FA1...

  19. Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate) : a phase 2, randomised, controlled trial

    NARCIS (Netherlands)

    Khanna, Dinesh; Denton, Christopher P.; Jahreis, Angelika; van Laar, Jacob M.; Frech, Tracy M.; Anderson, Marina E.; Baron, Murray; Chung, Lorinda; Fierlbeck, Gerhard; Lakshminarayanan, Santhanam; Allanore, Yannick; Pope, Janet E.; Riemekasten, Gabriela; Steen, Virginia; Müller-Ladner, Ulf; Lafyatis, Robert; Stifano, Giuseppina; Spotswood, Helen; Chen-Harris, Haiyin; Dziadek, Sebastian; Morimoto, Alyssa; Sornasse, Thierry; Siegel, Jeffrey; Furst, Daniel E.

    2016-01-01

    Background Systemic sclerosis is a rare disabling autoimmune disease with few treatment options. The efficacy and safety of tocilizumab, an interleukin 6 receptor-α inhibitor, was assessed in the faSScinate phase 2 trial in patients with systemic sclerosis. Methods We did this double-blind,

  20. A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development.

    Directory of Open Access Journals (Sweden)

    Philip J Byrd

    2016-03-01

    Full Text Available Patients with biallelic truncating mutations in PALB2 have a severe form of Fanconi anaemia (FA-N, with a predisposition for developing embryonal-type tumours in infancy. Here we describe two unusual patients from a single family, carrying biallelic PALB2 mutations, one truncating, c.1676_1677delAAinsG;(p.Gln559ArgfsTer2, and the second, c.2586+1G>A; p.Thr839_Lys862del resulting in an in frame skip of exon 6 (24 amino acids. Strikingly, the affected individuals did not exhibit the severe developmental defects typical of FA-N patients and initially presented with B cell non-Hodgkin lymphoma. The expressed p.Thr839_Lys862del mutant PALB2 protein retained the ability to interact with BRCA2, previously unreported in FA-N patients. There was also a large increased chromosomal radiosensitivity following irradiation in G2 and increased sensitivity to mitomycin C. Although patient cells were unable to form Rad51 foci following exposure to either DNA damaging agent, U2OS cells, in which the mutant PALB2 with in frame skip of exon 6 was induced, did show recruitment of Rad51 to foci following damage. We conclude that a very mild form of FA-N exists arising from a hypomorphic PALB2 allele.

  1. Production Support Flight Control Computers: Research Capability for F/A-18 Aircraft at Dryden Flight Research Center

    Science.gov (United States)

    Carter, John F.

    1997-01-01

    NASA Dryden Flight Research Center (DFRC) is working with the United States Navy to complete ground testing and initiate flight testing of a modified set of F/A-18 flight control computers. The Production Support Flight Control Computers (PSFCC) can give any fleet F/A-18 airplane an in-flight, pilot-selectable research control law capability. NASA DFRC can efficiently flight test the PSFCC for the following four reasons: (1) Six F/A-18 chase aircraft are available which could be used with the PSFCC; (2) An F/A-18 processor-in-the-loop simulation exists for validation testing; (3) The expertise has been developed in programming the research processor in the PSFCC; and (4) A well-defined process has been established for clearing flight control research projects for flight. This report presents a functional description of the PSFCC. Descriptions of the NASA DFRC facilities, PSFCC verification and validation process, and planned PSFCC projects are also provided.

  2. Roadmap for improving roof and façade windows in nearly zero-energy houses in Europe

    DEFF Research Database (Denmark)

    Skarning, Gunnlaug Cecilie Jensen; Hviid, Christian Anker; Svendsen, Svend

    2016-01-01

    comfort in nearly zero-energy houses located in the European cities Rome and Copenhagen. The aim was to identify options that can support the easy and robust design of future homes with typical use of roof and façade windows. Hourly daylight levels were calculated in DAYSIM, while space heating demand...

  3. 75 FR 51657 - Airworthiness Directives; Pratt & Whitney Canada Corp. (P&WC) PW615F-A Turbofan Engines

    Science.gov (United States)

    2010-08-23

    ... showed that the Fuel Filter Bypass Valve poppet in the Fuel Oil Heat Exchanger (FOHE) on that engine had... that the Fuel Filter Bypass Valve poppet in the Fuel Oil Heat Exchanger (FOHE) on that engine had worn... a dormant failure that could result in an unsafe condition. The PW615F-A engine Fuel Filter Bypass...

  4. Neurons in the monoaminergic nuclei of the rat and human central nervous system express FA1/dlk

    DEFF Research Database (Denmark)

    Jensen, Charlotte Harken; Meyer, M; Schrøder, Henrik Daa

    2001-01-01

    The gene DLK1 encodes a member of the epidermal growth factor (EGF) superfamily, delta-like (dlk). When exposed in vivo to the action of an unknown protease, this type 1 membrane protein generates a soluble peptide referred to as Fetal antigen 1 (FA1). By acting in juxtacrine as well as paracrine...

  5. Behind the Façade of Fee-Free education: Shadow Education and Its Implications for Social Justice

    Science.gov (United States)

    Bray, Mark; Kwo, Ora

    2013-01-01

    Most governments, at an official level, espouse the principles of the 1948 Universal Declaration of Human Rights. Among its statements is that education shall be free, at least in the elementary and fundamental stages. Yet while the façade of government education systems presents an image that instruction is free of charge, families across the…

  6. pH-sensitive Au–BSA–DOX–FA nanocomposites for combined CT imaging and targeted drug delivery

    Directory of Open Access Journals (Sweden)

    Huang H

    2017-04-01

    Full Text Available He Huang,1 Da-Peng Yang,2 Minghuan Liu,2 Xiangsheng Wang,1 Zhiyong Zhang,1 Guangdong Zhou,1 Wei Liu,1 Yilin Cao,1 Wen Jie Zhang,1 Xiansong Wang1 1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, National Tissue Engineering Center of China, Shanghai, 2College of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou, People’s Republic of China Abstract: Albumin-based nanoparticles (NPs as a drug delivery system have attracted much attention owing to their nontoxicity, non-immunogenicity, great stability and ability to bind to many therapeutic drugs. Herein, bovine serum albumin (BSA was utilized as a template to prepare Au–BSA core/shell NPs. The outer layer BSA was subsequently conjugated with cis-aconityl doxorubicin (DOX and folic acid (FA to create Au–BSA–DOX–FA nanocomposites. A list of characterizations was undertaken to identify the successful conjugation of drug molecules and targeted agents. In vitro cytotoxicity using a cell counting kit-8 (CCK-8 assay indicated that Au–BSA NPs did not display obvious cytotoxicity to MGC-803 and GES-1 cells in the concentration range of 0–100 µg/mL, which can therefore be used as a safe drug delivery carrier. Furthermore, compared with free DOX, Au–BSA–DOX–FA nanocomposites exhibited a pH-sensitive drug release ability and superior antitumor activity in a drug concentration-dependent manner. In vivo computed tomography (CT imaging experiments showed that Au–BSA–DOX–FA nanocomposites could be used as an efficient and durable CT contrast agent for targeted CT imaging of the folate receptor (FR overexpressed in cancer tissues. In vivo antitumor experiments demonstrated that Au–BSA–DOX–FA nanocomposites have selective antitumor activity effects on FR-overexpressing tumors and no adverse effects on normal tissues and

  7. Development of a Façade Assessment and Design Tool for Solar Energy (FASSADES

    Directory of Open Access Journals (Sweden)

    Jouri Kanters

    2014-03-01

    Full Text Available Planning energy-efficient buildings which produce on-site renewable energy in an urban context is a challenge for all involved actors in the planning process. The primary objective of this study was to develop a façade assessment and design tool for solar energy (FASSADES providing the necessary information for all stakeholders in the design process. The secondary objective was to demonstrate the tool by performing an assessment analysis of a building block. The FASSADES tool is a DIVA4Rhino script, combining Radiance/Daysim and EnergyPlus for simulating the annual production of solar thermal and photovoltaic systems on facades, the cost-effectiveness of the solar energy system, and the payback time. Different output methods are available; graphically within the 3D drawing environment and numerically within post-processing software. The tool was tested to analyse a building block within a city under Swedish conditions. Output of the developed tool showed that shading from nearby buildings greatly affects the feasibility of photovoltaic and solar thermal systems on facades.

  8. Research of Hubs Location Method for Weighted Brain Network Based on NoS-FA.

    Science.gov (United States)

    Weng, Zhengkui; Wang, Bin; Xue, Jie; Yang, Baojie; Liu, Hui; Xiong, Xin

    2017-01-01

    As a complex network of many interlinked brain regions, there are some central hub regions which play key roles in the structural human brain network based on T1 and diffusion tensor imaging (DTI) technology. Since most studies about hubs location method in the whole human brain network are mainly concerned with the local properties of each single node but not the global properties of all the directly connected nodes, a novel hubs location method based on global importance contribution evaluation index is proposed in this study. The number of streamlines (NoS) is fused with normalized fractional anisotropy (FA) for more comprehensive brain bioinformation. The brain region importance contribution matrix and information transfer efficiency value are constructed, respectively, and then by combining these two factors together we can calculate the importance value of each node and locate the hubs. Profiting from both local and global features of the nodes and the multi-information fusion of human brain biosignals, the experiment results show that this method can detect the brain hubs more accurately and reasonably compared with other methods. Furthermore, the proposed location method is used in impaired brain hubs connectivity analysis of schizophrenia patients and the results are in agreement with previous studies.

  9. Recoveries of rat lymph FA after administration of specific structured C-13-TAG

    DEFF Research Database (Denmark)

    Vistisen, Bodil; Mu, Huiling; Høy, Carl-Erik

    2003-01-01

    The potential of the specific structured TAG MLM [where M = caprylic acid (8:0) and L = linoleic acid (18:2n-6)] is the simultaneous delivery of energy and EFA. Compared with long-chain TAG (LLL), they may be more rapidly hydrolyzed and absorbed. This study examined the lymphatic recoveries...... of intragastrically administered L*L*L*, M*M*M*, ML*M, and ML*L* (where * = C-13-labeled FA) in rats. Lymph lipids were separated into lipid classes and analyzed by GC combustion isotope ratio MS. The recoveries of lymph TAG 18:2n-6 8 h after administration of L*L*L*, ML*M, and ML*L* were 38.6, 48.4, and 49.......1%, respectively, whereas after 24 h the recoveries were approximately 50% in all experimental groups. The exogenous contribution to lymph TAG 18:2n-6 was approximately 80 and 60% at maximum absorption of the specific structured TAG and L*L*L*, respectively, 3-6 h after administration. The tendency toward more...

  10. R245fa Flow Boiling inside a 4.2 mm ID Microfin Tube

    Science.gov (United States)

    Longo, G. A.; Mancin, S.; Righetti, G.; Zilio, C.

    2017-11-01

    This paper presents the R245fa flow boiling heat transfer and pressure drop measurements inside a mini microfin tube with internal diameter at the fin tip of 4.2 mm, having 40 fins, 0.15 mm high with a helix angle of 18°. The tube was brazed inside a copper plate and electrically heated from the bottom. Sixteen T-type thermocouples are located in the copper plate to monitor the wall temperature. The experimental measurements were carried out at constant mean saturation temperature of 30 °C, by varying the refrigerant mass velocity between 100 kg m-2 s-1 and 300 kg m-2 s-1, the vapour quality from 0.15 to 0.95, at two different heat fluxes: 30 and 60 kW m-2. The experimental results are presented in terms of two-phase heat transfer coefficient, onset dryout vapour quality, and frictional pressure drop. Moreover, the experimental measurements are compared against the most updated models for boiling heat transfer coefficient and frictional pressure drop estimations available in the open literature for microfin tubes.

  11. Effects of crowd size on referee decisions: analysis of the FA Cup.

    Science.gov (United States)

    Downward, Paul; Jones, Marc

    2007-12-01

    Data were collected on the number of first yellow cards awarded during 857 games, over six seasons (1996 - 2002), played in the Football Association (FA) Cup. Overall, a significantly higher number of yellow cards were awarded against the away team, while a non-linear relationship between crowd size and yellow cards was observed. In general, the probability of a yellow card being awarded against the home team decreased as crowd size increased, but was attenuated for the largest crowd sizes. Crowd size may be related to the probability of the home team receiving a yellow card in two potential ways. Crowd noise may be a decision-making heuristic whereby the likelihood that an incident is a foul is increased when accompanied by crowd noise. Alternatively, referees may seek to appease the crowd and are more likely to do so as crowd size increases. The present findings have implications for the training of match officials and for coaches and players as they prepare to play away from home.

  12. MECHANISM OF BIOACTIVITY OF LS2-FA GLASS-CERAMICS IN SBF AND DMEM MEDIUM

    Directory of Open Access Journals (Sweden)

    GABRIELA LUTIŠANOVÁ

    2012-09-01

    Full Text Available In this paper, the results of in vitro bioactivity of glass-ceramics in the Li2O–SiO2–CaO–P2O5–CaF2 (shorthand LS2-FA system immersed in two media (simulated body fluid (SBF and Dulbecco’s modified Eagle’s medium (DMEM are compared. Microprobe (EPMA and Scanning Electron Microscopy (SEM were used to detect the presence of a new phase on the surface and to characterize its layer. Inductively coupled plasma (ICP was used to monitor ion concentration changes in SBF with immersion time. The results show, that during the assay in vitro behaviour tests, the surface of the sample was partially dissolved and released of Si4+, Ca2+ and Li+ ions were released into the SBF medium. The results of surface characterization after in vitro tests revealed difference in the bioactivity of glass-ceramics with various time of immersion in SBF and DMEM. For the formation of an apatite-layer in an earlier testing period (1, 3 and 7 days, a pronounced difference was not observed between SBF and DMEM immersion. In the longer testing period in SBF (28 days, the apatite-layer was developed by periodic deposition of spherical bullets that covers the whole surface. The use of the acellular culture medium DMEM resulted in a delay at the start of precipitation.

  13. Comparison of thermal testing of MS9001FA type GTPs at shatura and nizhnevartovsk GRES

    Science.gov (United States)

    Ol'khovskii, G. G.

    2016-11-01

    Domestic power plants use combined-cycle plants in which a gas-turbine plant (GTP) and a steam turbine rotate a common electric generator. In this instance, it is impossible to measure the power of each of them, so we have to resort to some assumptions. We have succeeded to check the validity of these assumptions and possible errors of their application testing combined-cycle plants (CCP) with the same GTP and a steam turbine but operating each on its own electrical generator. Comparative tests of a MS901FA GTP of the PGU-400 power-generating unit commissioned at Shatura GRES (a thermal power station) and a GTP of the same type installed at Nizhnevartovsk GRES were performed. As a result of these tests, dependences of the electric power of both gas-turbine plants and a turbine outlet temperature on the inlet temperature were obtained. A relation of the GTP efficiency, heat and air rate on the load are determined, and characteristics of compressors and turbines of both GTPs are defined. The performed tests have confirmed the accuracy of the determined characteristics of the two GTPs using both a direct measurement of net power (Nizhnevartovsk GRES) and an indirect measurement (Shatura GRES).

  14. Over-expression of Gene FaASR Promotes Strawberry Fruit Coloring

    Directory of Open Access Journals (Sweden)

    Liu Zhongjie

    2015-11-01

    Full Text Available Fruit development and ripening is a complicate process. Although much progress has been made on the ripenig process, the molecular mechamism of fruit development is not yet clear. In this study, we used ‘Sweet Charlie’ strawberry as test materials, based on cloning the strawberries ASR homologous gene, we carried out the bioinformatics and temporal expression analysis of FaASR, by manipulating ASR gene expression level in strawberry fruit, we tested the changes of physiological indicators, including sugar, ABA, pigments content, and fruit firmness, as well as phenotypic changes. In addition, we measured the expression changes of some anthocyanin-related gene, such as CHS and UFGT, by which we revealed the regulation mechanisms of ASR gene over strawberry fruit ripening. Strawberry ASR contained a typical domain of ABA/WDS that was related to fruit ripening and stress-resistance, and ASR gene over-expression could promote strawberry fruit coloring, endogenous ABA and sucrose accumulation, fruit softening, and induced the transcription levels of anthocyanin-related genes CHS and UFGT. The present study will further reveal the molecular mechanisms of information transmission in fruit development, and will also play an important foundation for future molecular improvement of strawberries breeding.

  15. Language Training: English

    CERN Multimedia

    Françoise benz

    2005-01-01

    Oral Expression The next session will take place from January to March 2005. This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be a maximum of 10 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Timetable: Tuesday 11.30 to 13.30 Duration: 20 hours Price: 440 CHF (for a minimum of 8 students) Writing Professional Documents in English The next session will take place from January to March 2005. This course is designed for people with a good level of spoken English. Duration: 20 hours Price: 440 CHF (for 8 students) Timetable will be fixed after discussion with the students. For registration and further information on these courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: Tel. 73127. FORMATION EN LANGUES LANGUAGE TRAINING Françoise Benz 73127 langu...

  16. Language Training: English

    CERN Multimedia

    Françoise Benz

    2004-01-01

    Oral Expression The next session will take place from January to March 2005. This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be a maximum of 10 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Timetable: Tuesday 11.30 to 13.30 Duration: 20 hours Price: 440 CHF (for a minimum of 8 students) Writing Professional Documents in English The next session will take place from January to March 2005. This course is designed for people with a good level of spoken English. Duration: 20 hours Price: 440 CHF (for 8 students) Timetable will be fixed after discussion with the students. For registration and further information on these courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: Tel. 73127. FORMATION EN LANGUES LANGUAGE TRAINING Françoise Benz 73127 langua...

  17. Language Training: English Courses

    CERN Multimedia

    Françoise Benz

    2005-01-01

    General and Professional English Courses The next session will take place from 28 February to 24 June 2005 (2/3 weeks break at Easter). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow: tel. 72957. Oral Expression The next session will take place from March to June 2005. This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be a maximum of 10 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Duration: 20 hours Price: 440 CHF (for a minimum of 8 students) Timetable will be fixed after discussion with the students. Writing Professional Documents in English The next session will take place from March to June 2005. T...

  18. Language Training: English Courses

    CERN Multimedia

    Françoise Benz

    2005-01-01

    General and Professional English Courses The next session will take place from 28 February to 24 June 2005 (2/3 weeks break at Easter). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow: tel. 72957. Oral Expression The next session will take place from March to June 2005. This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be a maximum of 10 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Duration: 20 hours Price: 440 CHF (for a minimum of 8 students) Timetable will be fixed after discussion with the students. Writing Professional Documents in English The next session will take place from March to June 2005. Th...

  19. Language Training - English Training

    CERN Multimedia

    HR Department

    2009-01-01

    General and Professional English Courses The next session will take place: from 2nd March to end of June 2009 (1/2 weeks break at Easter). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Nathalie Dumeaux, tel. 78144. Oral Expression The next session will take place from 2nd March to end of June 2009 (1/2 weeks break at Easter). This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be on average of 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Duration: 30 hours Price: 660 CHF (for a minimum of 8 students) Writing Professional Documents in English The next session will take place from 2nd March to end of June 2009 (1/2 weeks break at Easter). This course is designed for people w...

  20. Language Training - English Training

    CERN Multimedia

    HR Department

    2009-01-01

    General and Professional English Courses The next session will take place: from 2nd March to end of June 2009 (1/2 weeks break at Easter). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Nathalie Dumeaux, tel. 78144. Oral Expression The next session will take place from 2nd March to end of June 2009 (1/2 weeks break at Easter). This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be an average of 8 participants per class. Speaking activities will include discussions, meeting simulations, role-plays, etc., depending on the needs of the students. Duration: 30 hours Price: 660 CHF (for a minimum of 8 students) Writing Professional Documents in English The next session will take place from 2nd March to end of June 2009 (1/2 weeks break at Easter). This course is designed for people ...

  1. Referee bias contributes to home advantage in English Premiership football.

    Science.gov (United States)

    Boyko, Ryan H; Boyko, Adam R; Boyko, Mark G

    2007-09-01

    Officiating bias is thought to contribute to home advantage. Recent research has shown that sports with subjective officiating tend to experience greater home advantage and that referees' decisions can be influenced by crowd noise, but little work has been done to examine whether individual referees vary in their home bias or whether biased decisions contribute to overall home advantage. We develop an ordinal regression model to determine whether various measures of home advantage are affected by the official for the match and by crowd size while controlling for team ability. We examine 5244 English Premier League (EPL) match results involving 50 referees and find that home bias differs between referees. Individual referees give significantly different levels of home advantage, measured as goal differential between the home and away teams, although the significance of this result depends on one referee with a particularly high home advantage (an outlier). Referees vary significantly and robustly in their yellow card and penalty differentials even excluding the outlier. These results confirm that referees are responsible for some of the observed home advantage in the EPL and suggest that home advantage is dependent on the subjective decisions of referees that vary between individuals. We hypothesize that individual referees respond differently to factors such as crowd noise and suggest further research looking at referees' psychological and behavioural responses to biased crowds.

  2. A Violent Response to Changing the Rules of the Game: The Case of “The Split” in Scottish Premier League Soccer

    OpenAIRE

    Ryan Dansby; R Todd Jewell

    2014-01-01

    The Scottish Premier League features the “split,” in which the league separates into two divisions after 33 games. This paper tests whether club behavior related to aggressive play is affected by the split. Our results indicate that there is no difference in the way bottom and top teams use normal fouls during post-split games. However, teams in the top division experience more yellow-card fouls after the split than teams in the bottom division. Thus, the split appears to influence the behavi...

  3. Dictionaries of Canadian English

    Directory of Open Access Journals (Sweden)

    John Considine

    2011-10-01

    Full Text Available

    Abstract: The lexicographical record of English in Canada began with wordlists of the late eighteenth, nineteenth, and early twentieth centuries. From the beginning of the twentieth century onwards, the general vocabulary of English in Canada has been represented in bilingual and monolingual dictionaries, often adapted from American or British dictionaries. In the 1950s, several important projects were initiated, resulting in the publication of general dictionaries of English in Canada, and of dictionaries of Canadianisms and of the vocabulary of particular regions of Can-ada. This article gives an overview of these dictionaries and of their reception, contextualizing them in the larger picture of the lexicography of Canada's other official language, French, and of a number of its non-official languages. It concludes by looking at the future of English-language lexicography in Canada, and by observing that although it has, at its best, reached a high degree of sophistication, there are still major opportunities waiting to be taken.

    Keywords: DICTIONARY, LEXICOGRAPHY, CANADIAN ENGLISH, CANADIANISMS, NATIONAL DICTIONARIES, CANADIAN FRENCH, CANADIAN FIRST NATIONS LAN-GUAGES, BILINGUAL DICTIONARIES, REGIONAL DICTIONARIES, UNFINISHED DICTIONARY PROJECTS

    Opsomming: Woordeboeke van Kanadese Engels. Die leksikografiese optekening van Engels in Kanada begin met woordelyste van die laat agtiende, neëntiende en vroeë twintigste eeue. Van die begin van die twintigste eeu af en verder, is die algemene woordeskat van Engels weergegee in tweetalige en eentalige woordeboeke, dikwels met wysiginge ontleen aan Ameri-kaanse en Britse woordeboeke. In die 1950's is verskeie belangrike projekte onderneem wat gelei het tot die publikasie van algemene woordeboeke van Engels in Kanada, en van woordeboeke van Kanadeïsmes en van die woordeskat van bepaalde streke van Kanada. Hierdie artikel gee 'n oorsig van dié woordeboeke, en van hul ontvangs, deur

  4. ATTITUDES AND ACHIEVEMENT ORIENTATIONS OF STUDENTS TOWARDS LEARNING OF SCIENCE AND MATHEMATICS IN ENGLISH

    Directory of Open Access Journals (Sweden)

    Tan Yao Sua

    2007-01-01

    Full Text Available This study examines the policy of teaching science and mathematics in English in the Malaysian educational system by focusing on the attitudes and achievement orientations of secondary school students towards the learning of these two subjects. Attitudes and achievement are two important outcomes of learning that will determine the effectiveness of an education policy. This study is based on a sample of 400 secondary school students selected from four non-premier schools. It looks into the students’ general attitudes and achievement orientations towards learning of science and mathematics as well as their variations according to four background variables, i.e., gender, ethnicity, types of feeder school and English achievement grades. It also examines the inter-correlations between the students’ attitudes and achievement orientations. Findings from statistical analyses of collected data were supplemented by more in-depth interviews. This study shows that the students’ general attitudes and achievement orientations towards learning of science and mathematics in English do not indicate that the policy has achieved its objective. However, their attitudes and achievement motivations vary according to the four background variables. The significant and positive inter-correlations between attitudes and achievement orientations towards learning of science and mathematics further confirm the causal relationship between these two important dimensions of learning.

  5. Dlk1/FA1 Is a Novel Endocrine Regulator of Bone and Fat Mass and Its Serum Level Is Modulated By Growth Hormone

    DEFF Research Database (Denmark)

    Abdallah, B.M.; Ding, M.; Jensen, C.H.

    2007-01-01

    , fat mass and bone mass in a dose-dependent manner. Reduced bone mass in FA1-mice was associated with the inhibition of mineral apposition rate and bone formation rates by 58% and 72% respectively. Since FA1 is co-localized with growth hormone (GH) in the pituitary gland, we explored the possible......Fat and bone metabolism are two linked processes regulated by several hormonal factors. FA1 (fetal antigen 1) is the soluble form of dlk1 (delta like 1), which is a member of the Notch-Delta family. We have previously identified FA1 as a negative regulator of bone marrow mesenchymal stem cell...... differentiation. Here, we studied the effects of circulating FA1 on fat and bone mass in vivo by generating mice expressing high serum levels of FA1 (FA1-mice) using the hydrodynamic-based gene transfer procedure (HGTP). We found that increased serum FA1 levels led to a significant reduction in total body weight...

  6. Broadening the perspectives of South African English and Afrikaans ...

    African Journals Online (AJOL)

    colored english, caribbean dutch, counting-out rimes, diglossia, dutch, english, ethnolects, etymology, family names, french, german, jewish afrikaans, jewish american english, jewish british english, jewish english, jewish irish english, jewish ...

  7. English for common entrance

    CERN Document Server

    Kossuth, Kornel

    2013-01-01

    Succeed in the exam with this revision guide, designed specifically for the brand new Common Entrance English syllabus. It breaks down the content into manageable and straightforward chunks with easy-to-use, step-by-step instructions that should take away the fear of CE and guide you through all aspects of the exam. - Gives you step-by-step guidance on how to recognise various types of comprehension questions and answer them. - Shows you how to write creatively as well as for a purpose for the section B questions. - Reinforces and consolidates learning with tips, guidance and exercises through

  8. Isolation and differentiation of chondrocytic cells derived from human embryonic stem cells using dlk1/FA1 as a novel surface marker

    DEFF Research Database (Denmark)

    Harkness, Linda; Taipaleenmaki, Hanna; Mahmood, Amer

    2009-01-01

    Few surface markers are available to monitor lineage differentiation during chondrogenesis. Recently, delta-like1/fetal antigen1 (dlk1/FA1), a transmembrane protein of the Notch/Delta/Serrata family, was shown to be essential for inducing early chondrogenesis. Thus, we investigated the possible use...... of dlk1/FA1 as a novel surface marker for chondroprogenitor cells during hESC differentiation. We found that, Dlk1/FA1 is expressed specifically in cells undergoing transition from proliferating to prehypertrophic chondrocytes during endochondral ossification of the mouse limb. In hESC cells, dlk1/FA1...... was not expressed by undifferentiated hESC, but expressed during in vitro embryoid bodies (hEBs) formation upon down-regulation of undifferentiated markers e.g. Oct 3/4. Similarly, dlk1/FA1 was expressed in chondrocytic cells during in vivo teratoma formation. Interestingly, treatment of hEBs with Activin B...

  9. A communicative grammar of English

    CERN Document Server

    Leech, Geoffrey

    2013-01-01

    A Communicative Grammar of English has long been established as a grammar innovative in approach, reliable in coverage, and clear in its explanations. This fully revised and redesigned third edition provides up-to-date and accessible help to teachers, advanced learners and undergraduate students of English. Part One looks at the way English grammar varies in different types of English, such as 'formal' and 'informal', 'spoken' and 'written'; Part Two focuses on the uses of grammar rather than on grammatical structure and Part Three provides a handy alphabetically arranged guide to

  10. Meaning and the English verb

    CERN Document Server

    Leech, Geoffrey

    2014-01-01

    Every language has its peculiar problems of meaning for the foreign learner. In the English language, some of the biggest yet most fascinating problems are concentrated in the area of the finite verb phrase: in particular, tense, aspect, mood and modality. Meaning and the English Verb describes these fields in detail for teachers and advanced students of English as a foreign or second language. This new third edition uses up-to-date examples to show differences and similarities between American and British english, reflecting a great deal of recent research in this area. It also takes account

  11. GLOBALIZATION, ANGLICISMS AND BUSINESS ENGLISH

    OpenAIRE

    Pop Anamaria-Mirabela; Sim Monica-Ariana

    2015-01-01

    For a long time, people have felt the need for a common language in order to communicate faster and better and English has become the global language, spreading across the world. Nowadays, more and more people learn and speak English for different reasons. The effect of it is that English started influencing the native languages of the speakers who use a great variety of words and expressions from English while speaking their respective languages. The aim of this paper is to analyze the influ...

  12. AP English language & composition

    CERN Document Server

    Bureau, Susan; Allen, John; Nesselrode, Katherine A; McGauley, Kristi R; Nesselrode, Katherine A; McGauley, Kristi R

    2013-01-01

    All Access for the AP® English Language and Composition Exam Book + Web + Mobile Everything you need to prepare for the Advanced Placement® exam, in a study system built around you! There are many different ways to prepare for an Advanced Placement® exam. What's best for you depends on how much time you have to study and how comfortable you are with the subject matter. To score your highest, you need a system that can be customized to fit you: your schedule, your learning style, and your current level of knowledge. This book, and the online tools that come with it, will help you personalize your AP® English Language and Composition prep by testing your understanding, pinpointing your weaknesses, and delivering flashcard study materials unique to you. The REA AP® All Access system allows you to create a personalized study plan through three simple steps: targeted review of exam content, assessment of your knowledge, and focused study in the topics where you need the most help. Here's how it works: Review ...

  13. Language Training: English Training

    CERN Multimedia

    Françoise Benz

    2004-01-01

    General and Professional English Courses The next session will take place from 04 October 2004 to 11 February 2005 (3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow, tel. 72957. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For further information, please contact Mr. Liptow, tel. 72957. Date and timetable will be fixed when there are sufficient participants enrolled. FORMATION EN LANGUES LANGUAGE TRAINING Françoise Benz 73127 langua...

  14. Language Training: English

    CERN Multimedia

    Françoise Benz

    2005-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. Oral Expression The next session will take place from January to March 2005. This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be a maximum of 10 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Timetable: Tuesday 11.30 to 13.30 Duration: 20 hours Price: 440 CHF (for a minimum of 8 students) Writing Professional Documents in English The next session will take place from Januar...

  15. Language Training: English Training

    CERN Multimedia

    Françoise Benz

    2004-01-01

    La prochaine session se déroulera du 04 octobre 2004 au 11 février 2005 (interruption de 3 semaines à Noël). Ces cours s'adressent à toute personne travaillant au CERN ainsi qu'à leur conjoint. Pour vous inscrire et voir tout le détail des cours proposés, consultez nos pages Web : http://cern.ch/Training Vous pouvez aussi contacter M. Liptow, tél. 72957. General and Professional English Courses The next session will take place from 04 October 2004 to 11 February 2005 (3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow, tel. 72957. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants ...

  16. Language Training: English Training

    CERN Multimedia

    Françoise Benz

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. General and Professional English Courses The next session will take place from 04 October 2004 to 11 February 2005 (3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow, tel. 72957. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in...

  17. Language Training: English Training

    CERN Multimedia

    Françoise Benz

    2004-01-01

    General and Professional English Courses The next session will take place from 04 October 2004 to 11 February 2005 (3 weeks break at Christmas). These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mr. Liptow, tel. 72957. Oral Expression This course is intended for people with a good knowledge of English who want to practise and maintain their speaking skills while extending their vocabulary. There will be approximately 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Duration: 20 hours (2 hours a week) Price: 440 CHF (for 8 students) For further information, please contact Mr. Liptow, tel. 72957. Date and timetable will be fixed when there are sufficient participants enrolled. FORMATION EN LANGUES LANGUAGE TRAINING Françoise Benz 73127 languag...

  18. English and French courses

    CERN Document Server

    2014-01-01

    If one of your New Year’s resolutions is to learn a language, there is no excuse anymore!   You can attend one of our English or French courses and you can practise the language with a tandem partner! Cours d’anglais général et professionnel La prochaine session se déroulera du 3 mars au 27 juin 2014. Ces cours s’adressent à toute personne travaillant au CERN ainsi qu’à leur conjoint. Pour vous inscrire et voir tout le détail des cours proposés, consultez nos pages web : http://cern.ch/Training. Oral Expression The next session will take place from 3 March to 27 June 2014. This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be an average of 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Writing Profe...

  19. English Book Club

    CERN Multimedia

    English Book Club

    The minutes of the AGM held on Tuesday November 17th can now be found on the club web-site: http://club-englishbookclub.web.cern.ch. A new version of the club’s book data-base is also available on the web: http://club-englishbookclub.web.cern.ch/club-englishbookclub/Export/index.html The last book selection for 2009 is done and the order for the new books has been placed, with luck they will be on the shelves before the end of year break. The English Book Club has a growing collection of over 4500 English language books, mostly general fiction with a sprinkling of nonfiction and children’s books. New books are purchased regularly and the books are shelved in our club room which is accessible to members at all times. Membership is open to all (staff and external) and there is a special tariff for short term students. See the club’s website at http://cern.ch/englishbookclub for more details.

  20. ENGLISH BOOK CLUB

    CERN Multimedia

    English Book Club

    2009-01-01

    http://club-englishbookclub.web.cern.ch A note to our members Dear Members, Many thanks to all of you who have paid up now. However, there are still some late payers and Morna would appreciate knowing if they will pay for 2009/2010 or if they have left the club. At the AGM on 17 November it was decided that a 3 month delay for key reimbursement will be given to all present and past members, BUT after 31.3.2010 no reimbursement will be given out. We are in the process of making changes to the access to the club for paid-up, active members only. Some of you have told Morna you will pay on your next visit to CERN, that is ok but please try to do this by 15 December if possible. A new version of the club’s book data-base is available on the web: http://club-englishbookclub.web.cern.ch/club-englishbookclub/Export/index.html The English Book Club has a growing collection of over 4500 English language books, mostly general fiction with a sprinkling of nonfiction and children’s books. New books...

  1. Optimizing Client Latency in a Distributed System by Using the “Remote Façade” Design Pattern

    Directory of Open Access Journals (Sweden)

    Cosmin RABLOU

    2010-01-01

    Full Text Available In this paper we investigate the role of the Remote Façade pattern in the optimization of dis-tributed systems. The intent of this pattern is to wrap fine-grained remote objects in a coarse-grained interface and thus greatly reduce the total number of calls executed over the network. The measurement of the performance gain achieved by implementing this pattern is done through testing with a distributed application written in C# and using the latest Microsoft framework for distributed systems (Windows Communication Framework. Furthermore, we will be presenting the scenarios in which the implementation of the Remote Façade pattern brings a significant performance gain. Finally we show further scenarios in which the per-formance brought by this pattern can be investigated.

  2. High resolution crystal structures of the receptor-binding domain of Clostridium botulinum neurotoxin serotypes A and FA

    Directory of Open Access Journals (Sweden)

    Jonathan R. Davies

    2018-03-01

    Full Text Available The binding specificity of botulinum neurotoxins (BoNTs is primarily a consequence of their ability to bind to multiple receptors at the same time. BoNTs consist of three distinct domains, a metalloprotease light chain (LC, a translocation domain (HN and a receptor-binding domain (HC. Here we report the crystal structure of HC/FA, complementing an existing structure through the modelling of a previously unresolved loop which is important for receptor-binding. Our HC/FA structure also contains a previously unidentified disulphide bond, which we have also observed in one of two crystal forms of HC/A1. This may have implications for receptor-binding and future recombinant toxin production.

  3. Homework Practices of English and Non-English-Speaking Parents

    Science.gov (United States)

    Thelamour, Barbara; Jacobs, D'Andrea L.

    2014-01-01

    This study compared the homework practices of English-speaking and non-English-speaking parents. Using a national data set of 7,992 students across ages and ethnicities, the frequency and type of homework practices were investigated. Statistical analysis revealed significant (though small) differences between the overall homework practices between…

  4. Botswana English: Implications for English Language Teaching and Assessment

    Science.gov (United States)

    Alimi, Modupe

    2011-01-01

    Concerted efforts to characterise Botswana English (BE), though still referred to as "a variety in development", have validated its existence. However, the teaching and assessment of English in the high schools do not seem to have responded to the development of this variety. This paper discusses the viability of using Standard British…

  5. Non-Native English Varieties: Thainess in English Narratives

    Science.gov (United States)

    Singhasak, Piyahathai; Methitham, Phongsakorn

    2016-01-01

    This study aims at examining Thainess as a writing strategy used in non-literary texts written by non-professional bilingual writers. These writers are advanced language learners who are pursuing their Master's degree in English. Seven English narratives of their language learning experiences were analyzed based on Kachruvian's framework of…

  6. Subclassification of English Adjectives for French to English Machine Translation.

    Science.gov (United States)

    Flanagan, Mary A.

    1990-01-01

    Advances the hypothesis that, when translating French personal constructions involving an adjective and a verb infinitive into English, the property of the English adjective determines whether the verb will be translated as an infinitive or as a gerund. Alternatives for handling such translations in machine translation systems are explored. (five…

  7. Orientations towards English among English-Medium Instruction Students

    Science.gov (United States)

    Karakas, Ali

    2015-01-01

    Based on the empirical data of my PhD research, this paper analyses the perceptions of 351 undergraduate students enrolled at English-medium universities towards English in terms of the language ideology framework. The students were purposively sampled from three programs at three Turkish universities. The data were drawn from student opinion…

  8. English Verb Accuracy of Bilingual Cantonese-English Preschoolers

    Science.gov (United States)

    Rezzonico, Stefano; Goldberg, Ahuva; Milburn, Trelani; Belletti, Adriana; Girolametto, Luigi

    2017-01-01

    Purpose: Knowledge of verb development in typically developing bilingual preschoolers may inform clinicians about verb accuracy rates during the 1st 2 years of English instruction. This study aimed to investigate tensed verb accuracy in 2 assessment contexts in 4- and 5-year-old Cantonese-English bilingual preschoolers. Method: The sample included…

  9. Perception of English palatal codas by Korean speakers of English

    Science.gov (United States)

    Yeon, Sang-Hee

    2003-04-01

    This study aimed at looking at perception of English palatal codas by Korean speakers of English to determine if perception problems are the source of production problems. In particular, first, this study looked at the possible first language effect on the perception of English palatal codas. Second, a possible perceptual source of vowel epenthesis after English palatal codas was investigated. In addition, individual factors, such as length of residence, TOEFL score, gender and academic status, were compared to determine if those affected the varying degree of the perception accuracy. Eleven adult Korean speakers of English as well as three native speakers of English participated in the study. Three sets of a perception test including identification of minimally different English pseudo- or real words were carried out. The results showed that, first, the Korean speakers perceived the English codas significantly worse than the Americans. Second, the study supported the idea that Koreans perceived an extra /i/ after the final affricates due to final release. Finally, none of the individual factors explained the varying degree of the perceptional accuracy. In particular, TOEFL scores and the perception test scores did not have any statistically significant association.

  10. An Introduction to English Teaching, A Textbook for English Educators

    Science.gov (United States)

    Lin, Grace Hui Chin; Chien, Paul Shih-chieh

    2010-01-01

    Teaching English became a professional and academic field from a half century ago. Many researches for teacher education and teacher training have been conducted in order to raise the English as well as the foreign language trainers' knowledge and capabilities in carrying out effective lessons in classroom. During second millennium of speedily…

  11. Axiological Role of English Adjectives in English Language Teaching

    Science.gov (United States)

    Zerkina, Natalya N.; Kostina, Nataliia N.; Urazayeva, Nailya R.; Lomakina, Yekaterina A.; Emets, Tatiana V.; Gallyamova, Maria S.; Melnikova, Elena P.; Trutnev, Alexey Yu.; Lukina, Oksana A.

    2016-01-01

    The article focuses on peculiarities of English adjective teaching as one of main and important lexicological basis. As the English language nowadays is important and universal as a native language of worldwide society, exactly that's why process of learning must include wide range of techniques not only as a process of learning theories but also…

  12. Perception of "English" and Motivation in Learning English

    Science.gov (United States)

    Sahin, Mehmet; Seçer, Sule Y. E.; Erisen, Yavuz

    2016-01-01

    This study aims to present high school students' perception of "English" through the impressions and images and the effect of these perceptions on their motivation in learning English. This qualitative study is based on the data about students' metaphors and the focus group interview to determine their effect on the students' motivation.…

  13. The impact of teachers' limited English proficiency on English ...

    African Journals Online (AJOL)

    A comparison of teacher and learner written errors was made. Based on the findings, a questionnaire was designed to determine the extent of the impact of teachers' limited English proficiency on learners' English proficiency. The findings of the questionnaire responses are presented. Recommendations are made on how ...

  14. WiFi : Une nouvelle façon de combler le fossé numérique ? | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    13 juil. 2011 ... Se brancher à Internet en utilisant une simple antenne faite d'aluminium et une carte de réseau sans fil! Voilà une façon de donner un nouvel élan au développement économique, explique M. Onno Purbo, spécialiste des technologies de l'information et des communications (TIC) basé à Jakarta qui était de ...

  15. Environmental assessment of façade-building systems and thermal insulation materials for different climatic conditions

    OpenAIRE

    Sierra-Pérez, Jorge

    2016-01-01

    In the European Union, the building sector accounts for more than 40% of the total energy consumption and environmental impacts, representing the area with the greatest potential for intervention. In addition to the existing policies that promote energy efficiency in buildings, the embodied energy and the environmental impacts contained in the building materials should be considered. In the case of the construction of insulation façade systems, the environmental implications are different dep...

  16. Improving Utilization of F/A-18 Simulator CUBIC Instructors at VFA-106, Naval Air Station Oceana, VA

    OpenAIRE

    Mallory, William; Rivera, Rich; Swinford, William; BRB Consulting

    2010-01-01

    EMBA Project Report EXECUTIVE SUMMARY: Strike Fighter Squadron ONE ZERO SIX (VFA-106), the only East Coast F/A-18 Fleet Replacement Squadron (FRS), has identified problems in Cubic Instructor (CI) capacity during periods of high demand as a result of combining series of aircraft, C/D and E/F, into larger “Super” classes. Subsequently, the squadron is forced to augment CIs with Instructor Pilots (IPs) or Instructor Weapons System Officers (IWSOs) to increase capacity or foreg...

  17. Researching awareness and attitudes : a study of world Englishes and English teachers in South Korea

    OpenAIRE

    Ahn, Hyejeong

    2017-01-01

    This study explores the awareness and attitudes of English teachers in South Korea (ETSK) toward eight selected varieties of English: American English (AmE), British English (BrE), Canadian English (CaE), Singaporean English (SiE), Indian English (InE), Chinese English (ChE), Japanese English (JaE) and Korean English (KoE). Data, consisting of 204 questionnaires and 63 interviews, is collected from both Korean and non-Korean English teachers, from two major regions, Busan Gyeongnam and Seoul ...

  18. Simulation-based method to determine climatic energy strategies of an adaptable building retrofit façade system

    International Nuclear Information System (INIS)

    Capeluto, I. Guedi; Ochoa, Carlos E.

    2014-01-01

    Vast amounts of the European residential stock were built with limited consideration for energy efficiency, yet its refurbishment can help reach national energy reduction goals, decreasing environmental impact. Short-term retrofits with reduced interference to inhabitants can be achieved by upgrading facades with elements that enhance energy efficiency and user comfort. The European Union-funded Meefs Retrofitting (Multifunctional Energy Efficient Façade System) project aims to develop an adaptable mass-produced facade system for energy improvement in existing residential buildings throughout the continent. This article presents a simplified methodology to identify preferred strategies and combinations for the early design stages of such system. This was derived from studying weather characteristics of European regions and outlining climatic energy-saving strategies based on human thermal comfort. Strategies were matched with conceptual technologies like glazing, shading and insulation. The typical building stock was characterized from statistics of previous European projects. Six improvements and combinations were modelled using a simulation model, identifying and ranking preferred configurations. The methodology is summarized in a synoptic scheme identifying the energy rankings of each improvement and combination for the studied climates and façade orientations. - Highlights: • First results of EU project for new energy efficient façade retrofit system. • System consists of prefabricated elements with multiple options for flexibility. • Modular strategies were determined that adapt to different climates. • Technologies matching the strategies were identified. • Presents a method for use and application in different climates across Europe

  19. Fluorophore Absorption Size Exclusion Chromatography (FA-SEC): An Alternative Method for High-Throughput Detergent Screening of Membrane Proteins.

    Science.gov (United States)

    Lin, Sung-Yao; Sun, Xing-Han; Hsiao, Yu-Hsuan; Chang, Shao-En; Li, Guan-Syun; Hu, Nien-Jen

    2016-01-01

    Membrane proteins play key roles in many fundamental functions in cells including ATP synthesis, ion and molecule transporter, cell signalling and enzymatic reactions, accounting for ~30% genes of whole genomes. However, the hydrophobic nature of membrane proteins frequently hampers the progress of structure determination. Detergent screening is the critical step in obtaining stable detergent-solubilized membrane proteins and well-diffracting protein crystals. Fluorescence Detection Size Exclusion Chromatography (FSEC) has been developed to monitor the extraction efficiency and monodispersity of membrane proteins in detergent micelles. By tracing the FSEC profiles of GFP-fused membrane proteins, this method significantly enhances the throughput of detergent screening. However, current methods to acquire FSEC profiles require either an in-line fluorescence detector with the SEC equipment or an off-line spectrofluorometer microplate reader. Here, we introduce an alternative method detecting the absorption of GFP (FA-SEC) at 485 nm, thus making this methodology possible on conventional SEC equipment through the in-line absorbance spectrometer. The results demonstrate that absorption is in great correlation with fluorescence of GFP. The comparably weaker absorption signal can be improved by using a longer path-length flow cell. The FA-SEC profiles were congruent with the ones plotted by FSEC, suggesting FA-SEC could be a comparable and economical setup for detergent screening of membrane proteins.

  20. Diffusion tensor MRI tractography reveals increased fractional anisotropy (FA) in arcuate fasciculus following music-cued motor training.

    Science.gov (United States)

    Moore, Emma; Schaefer, Rebecca S; Bastin, Mark E; Roberts, Neil; Overy, Katie

    2017-08-01

    Auditory cues are frequently used to support movement learning and rehabilitation, but the neural basis of this behavioural effect is not yet clear. We investigated the microstructural neuroplasticity effects of adding musical cues to a motor learning task. We hypothesised that music-cued, left-handed motor training would increase fractional anisotropy (FA) in the contralateral arcuate fasciculus, a fibre tract connecting auditory, pre-motor and motor regions. Thirty right-handed participants were assigned to a motor learning condition either with (Music Group) or without (Control Group) musical cues. Participants completed 20minutes of training three times per week over four weeks. Diffusion tensor MRI and probabilistic neighbourhood tractography identified FA, axial (AD) and radial (RD) diffusivity before and after training. Results revealed that FA increased significantly in the right arcuate fasciculus of the Music group only, as hypothesised, with trends for AD to increase and RD to decrease, a pattern of results consistent with activity-dependent increases in myelination. No significant changes were found in the left ipsilateral arcuate fasciculus of either group. This is the first evidence that adding musical cues to movement learning can induce rapid microstructural change in white matter pathways in adults, with potential implications for therapeutic clinical practice. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  1. Fluorophore Absorption Size Exclusion Chromatography (FA-SEC: An Alternative Method for High-Throughput Detergent Screening of Membrane Proteins.

    Directory of Open Access Journals (Sweden)

    Sung-Yao Lin

    Full Text Available Membrane proteins play key roles in many fundamental functions in cells including ATP synthesis, ion and molecule transporter, cell signalling and enzymatic reactions, accounting for ~30% genes of whole genomes. However, the hydrophobic nature of membrane proteins frequently hampers the progress of structure determination. Detergent screening is the critical step in obtaining stable detergent-solubilized membrane proteins and well-diffracting protein crystals. Fluorescence Detection Size Exclusion Chromatography (FSEC has been developed to monitor the extraction efficiency and monodispersity of membrane proteins in detergent micelles. By tracing the FSEC profiles of GFP-fused membrane proteins, this method significantly enhances the throughput of detergent screening. However, current methods to acquire FSEC profiles require either an in-line fluorescence detector with the SEC equipment or an off-line spectrofluorometer microplate reader. Here, we introduce an alternative method detecting the absorption of GFP (FA-SEC at 485 nm, thus making this methodology possible on conventional SEC equipment through the in-line absorbance spectrometer. The results demonstrate that absorption is in great correlation with fluorescence of GFP. The comparably weaker absorption signal can be improved by using a longer path-length flow cell. The FA-SEC profiles were congruent with the ones plotted by FSEC, suggesting FA-SEC could be a comparable and economical setup for detergent screening of membrane proteins.

  2. Validation of a Swedish version of the Facial Disability Index (FDI) and the Facial Clinimetric Evaluation (FaCE) scale.

    Science.gov (United States)

    Marsk, Elin; Hammarstedt-Nordenvall, Lalle; Engström, Mats; Jonsson, Lars; Hultcrantz, Malou

    2013-06-01

    Swedish versions of the Facial Disability Index (FDI) and Facial Clinimetric Evaluation (FaCE) scale are psychometrically valid. Both questionnaires can be used for clinical studies on peripheral facial palsy patients, and provide important information on quality of life. To translate and validate Swedish versions of the FDI and FaCE scale in patients with peripheral facial palsy. Translation of the original questionnaires followed international guidelines. Internal consistency and test-retest stability were assessed in adult patients with stable peripheral facial palsy. Facial function was examined with the Sunnybrook and House-Brackmann scales. Subjects answered the questionnaires twice with a 2-week interval. Validity was assessed by comparing FDI and FaCE scale scores to SF-36 and Sunnybrook/House-Brackmann scores. Ninety-three patients were included, 53% women and 47% men, mean age 56.9 years and mean duration of palsy 51.9 months. The questionnaires showed good/excellent psychometric properties with Cronbach's α scores between 0.76 and 0.92. In the test-retest analysis, intra-class correlation coefficients were very good for both questionnaires with scores of 0.83-0.97. Both questionnaires showed good sensitivity to discriminate between patients with varying degrees of facial dysfunction. Moderate to strong correlation was found between the social domains in the questionnaires when compared with the equivalent domains in SF-36.

  3. Comparative Study on Acoustic Behavior Between Light Multi-layered and Traditional Façades

    Directory of Open Access Journals (Sweden)

    Ruiz, L.

    2012-09-01

    Full Text Available Light multi-layered facade systems in general have been acoustically little studied. The data available suggests they do not usually fulfil the sound insulation values required in the Technical Building Code (CTE in particularly in noisy environments. Therefore the main objectives of this study, is to obtain light multi-layered façade systems with a high degree of acoustic insulation that can be used in noisy environments. While in turn showing excellent thermal characteristics, without neglecting important aspects such as the sustainability of materials, industrialization, costs, among others. This article will explain the process that has been followed to carry out an investigation on the acoustic behaviour of light multi-layered facades. For this purpose acoustic behaviour and sound intensimetry measurement methods have been used. After obtaining these results, a comparison between light multi-layered and traditional facades was made.Los sistemas de fachadas multicapas ligeras acústicamente, en general han sido poco estudiados. Los primeros datos que se tienen es que no suelen alcanzar los valores de aislamiento acústico requeridos en el Código Técnico de la Edificación (CTE en entornos especialmente ruidosos. Los objetivos principales de esta investigación son obtener fachadas multicapas ligeras con un alto grado de aislamiento acústico, que puedan ser empleados en entornos ruidosos. Al mismo tiempo que presenten excelentes características térmicas, sin descuidar aspectos tan importantes como la sostenibilidad, industrialización, costes, etc. En este artículo se explicará el proceso que se ha llevado a cabo para realizar una investigación relacionada con el comportamiento acústico de fachadas multicapas ligeras. Para ello se han empleado los métodos de medida del comportamiento acústico a ruido aéreo e intensimetría sonora. Una vez obtenidos estos resultados se realiza una comparativa entre las fachadas multicapas ligeras

  4. Fałszywy znak równości

    Directory of Open Access Journals (Sweden)

    Efraim Zuroff

    2012-12-01

    Full Text Available The equivalency canard Efraim Zuroff's text, originally published in Haaretz magazine, is a review of Timothy Snyder's Bloodlands. Snyder distinguishes six main mass murders commited by Nazi Germany and Soviet Union during the period of the Third Reich's existence. In Zuroff's opinion there are some significant differences between these tragedies. Dubious comparisons proposed by Snyder made the Holocaust most affected. Describing the Shoah as one of the six equally horryfying mass murders, the author ignores its ideological roots. Roots that sentenced to death all Jews  - regardless of their political views, religious practicies or the level of identification with Jewish community. Moreover Snyder takes no notice of the georaphical scope of the Holocaust. He also does not notice the fact, that the Nazis effectively managed to make so many Europeans their accomplices, who actively supported the Shoah.   Fałszywy znak równości Tekst Efraima Zuroffa, który pierwotnie ukazał się w piśmie Haaretz, to recenzja książki Skrwawione ziemie Timothy Snydera. Snyder wyróżnia sześć głównych masowych mordów popełnionych przez Niemcy i Związek Radziecki w okresie, który odpowiada istnieniu Trzeciej Rzeszy. Istnieją jednak, zdaniem Zuroffa, znaczące różnice między tymi tragediami. Na wątpliwych porównaniach, które proponuje Snyder, najbardziej „ucierpiał” Holokaust. Opisując Shoah jako jeden z sześciu równie straszliwych, masowych mordów, autor pomija jego ideologiczne korzenie, które sprawiały, że na śmierć skazany był każdy bez wyjątku Żyd, niezależnie od jego poglądów politycznych, praktyk religijnych czy stopnia identyfikacji z żydowską wspólnotą. Ponadto Snyder ignoruje ogromny zasięg geograficzny Holokaustu. Nie zauważa także skuteczności, z jaką naziści potrafili uczynić swoimi wspólnikami tak wielu Europejczyków, którzy w konsekwencji aktywnie wspomagali Shoah.

  5. 7 CFR 247.13 - Provisions for non-English or limited-English speakers.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Provisions for non-English or limited-English speakers... § 247.13 Provisions for non-English or limited-English speakers. (a) What must State and local agencies do to ensure that non-English or limited-English speaking persons are aware of their rights and...

  6. English RP: Ancient or Modern.

    Science.gov (United States)

    Gimson, Alfred C.

    1979-01-01

    Discusses changes in the pronunciation of colloquial Brltish English, reflecting changing social attitudes toward traditional Received Pronunciation. Finds that a study is needed to determine a new standard for the use of future foreign students of English. A pilot study is described. (IFS/WGA) i

  7. How is English "A" Pronounced?

    Science.gov (United States)

    Wakelin, Martyn F.

    1977-01-01

    Discusses, from both historical and sociolinguistic viewpoints, the changing of the phoneme /a/ in colloquial English. The rather "bright, moderately open" sound, once considered standard English, has been and is moving toward a more open and back articulation. (IFS/WGA)

  8. Electronic Learning of Business English

    OpenAIRE

    Milošević Danica

    2014-01-01

    This paper deals with one approach to organising electronic learning of a Business English language course. The paper will explain the basic structure of electronic learning, explore its principles and focus on the effects of this type of learning, trying to make English language teachers aware of the possibilities that this system has to offer to its users.

  9. Electronic Learning of Business English

    Directory of Open Access Journals (Sweden)

    Milošević Danica

    2014-03-01

    Full Text Available This paper deals with one approach to organising electronic learning of a Business English language course. The paper will explain the basic structure of electronic learning, explore its principles and focus on the effects of this type of learning, trying to make English language teachers aware of the possibilities that this system has to offer to its users.

  10. English Teaching at Lilydale High.

    Science.gov (United States)

    Mayer, Valerie; Matcott, Mark; Lyons, Janet; Flessa, Demi; Hayman, Anna; Hough, Peter

    2002-01-01

    Presents six narratives from teachers including: "VCE English at Lilydale High School" (Valerie Mayer); "Should 'I' Be Their Teacher" (Mark Matcott); "Teaching Poetry to Year 7 English Students" (Janet Lyons); "Creative Art Therapy and Mandalas" (Demi Flessa); "Would the 'Real' Teacher Please Stand…

  11. Cultural Identity in Korean English

    Science.gov (United States)

    Chang, Bok-Myung

    2010-01-01

    This study aims to investigate the cultural identity of Korean English and to make the intercultural communications among non-native speakers successful. The purposes of this study can be summarized as follows: 1) to recognize the concept of English as an International Language (EIL), 2) to emphasize cross-cultural understanding in the globalized…

  12. Instructional Materials Vocational Related English.

    Science.gov (United States)

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater.

    This preliminary draft of instructional materials for an English curriculum offering vocational preparation focuses on grammar concepts, selected vocational English topics, and the use of resource materials. The unit plans contain general and specific behavioral objectives, student activities, and teaching procedures. Information sheets, student…

  13. ACCA College English Teaching Mode

    Science.gov (United States)

    Ding, Renlun

    2008-01-01

    This paper elucidates a new college English teaching mode--"ACCA" (Autonomous Cooperative Class-teaching All-round College English Teaching Mode). Integrated theories such as autonomous learning and cooperative learning into one teaching mode, "ACCA", which is being developed and advanced in practice as well, is the achievement…

  14. Japanese Attitudes toward English Accents.

    Science.gov (United States)

    Chiba, Reiko; And Others

    1995-01-01

    Examined the attitudes of 169 Japanese university students toward varieties of spoken English. Results found that the students with more instrumental motivation were more positive toward nonnative English accents than those with less instrumental motivation, and that the students' familiarity with accents had an influence on their acceptance of…

  15. What Matters in English Literature?

    Science.gov (United States)

    Parker, Fred

    2005-01-01

    The article talks about how--and whether--"English" can justify itself as an academic discipline, and about the pressures on it to do so. In the search for justification, is it the creative writer or the critic who provides the crucial element of value? Particular reference is made to the tradition of English at Cambridge, where the…

  16. Evaluating Workplace English Language Programs

    Science.gov (United States)

    Ekkens, Kristin; Winke, Paula

    2009-01-01

    Companies across the United States provide workplace English classes to non-native-English-speaking employees to increase productivity, retention, and on-the-job safety. Institutions that financially support the programs often require evidence of learning through standardized tests as a prerequisite for continued funding. However, the tests…

  17. GLOBALIZATION, ANGLICISMS AND BUSINESS ENGLISH

    Directory of Open Access Journals (Sweden)

    Pop Anamaria-Mirabela

    2015-07-01

    Full Text Available For a long time, people have felt the need for a common language in order to communicate faster and better and English has become the global language, spreading across the world. Nowadays, more and more people learn and speak English for different reasons. The effect of it is that English started influencing the native languages of the speakers who use a great variety of words and expressions from English while speaking their respective languages. The aim of this paper is to analyze the influence of Anglicisms on the Romanian vocabulary, especially on the business vocabulary. Our paper focuses on English for Business and Economics, as we have been teaching business English to students from the Department of International Business for several years. The research undertaken in this paper is a theoretical research, concentrating on the controversies that surrounded this highly debated subject by the linguists: should Anglicisms be used in Romanian or not? In this regard, there are two sides: on one hand those who are rather supportive of the trend and those (and here we mention highly reputed Romanian linguists like George Pruteanu or Eugen Simion who were categorically against it. The paper provides the results of a survey conducted by “Special Eurobarometer 243” showing that English is the most widely spoken language in Europe with a score of 51%. The concept of “romgleza” tends to replace the Romanian language in large corporations and not only and this is a natural trend, considering the “invasion” of the English language. A conversation in “romgleza” combines Romanian and English elements, thus resulting a technical jargon, the English words being used especially in areas like IT, marketing, management. This is due to the fact that in these areas the daily exposure to English is higher because everything people in these fields do is connected to English. Romgleza appeared because in Romanian there are no words to express the

  18. Transformations in the English Classroom

    Directory of Open Access Journals (Sweden)

    Veronica L. Diptoadi

    2016-02-01

    Full Text Available In the past few years English has been taught at the elementary school level. However, many schools in Surabaya have introduced English in their curriculum at the pre-school level. In this paper the writer describes a Semi-International School in Surabaya as a model, because English is given since the play group level where students are about 2-3 years old. Thus, the focus of this paper is on be the reasons why English is taught at such an early age, constructivism as the theoretical base of the school curriculum, the English program based on topic-centered learning and activity-based approach and the facilities needed to support the whole teaching-learning process at the school

  19. Prepositions in MSA and English

    Directory of Open Access Journals (Sweden)

    Saad Nasser Aldwayan

    2013-01-01

    Full Text Available Spatial scenes are identical in the world languages. However, cultures may diverge in profiling spatial scenes (Levinson 2003. This paper selects for study the prepositions in and on in English and their Modern Standard Arabic (MSA counterparts fi and 3ala, arguing that MSA and English seem to diverge in the spatial configurations and meanings of these prepositions. The sub-schemas of CONTAINMENT (in-ness in MSA are found to partially overlap with those of English, with the other sub-schemas being taken care of by SUPPORT (on-ness and PUNCTUALITY (point-ness. Such differences classify MSA more as a CONTAINMENT-based language than English, which seems to prefer SUPPORT and PUNCTUALITY. However, English and MSA seem to converge in their metaphoric conceptualizations of states owing to conceptual embodiment (Lakoff 1987. The article discusses the implications of such findings for spatial cognition and cultural cognition and EFL/ESL writing and translating.

  20. Life after oral English certification

    DEFF Research Database (Denmark)

    Dimova, Slobodanka

    2017-01-01

    Internationalization of higher education has resulted in rapid developments of English-medium instruction (EMI) courses in non-Anglophone countries in Europe and Asia. Due to the growing concerns about lecturers' ability to teach in English, several European universities have implemented policies...... for internal assessment of lecturers' English proficiency to ensure the quality of teaching in EMI programs. However, research on the measured construct and the reliability and the validity of these assessments remains scarce. Based on interviews with tested university lecturers and formative feedback analysis......, this study discusses the consequences resulting from score and feedback interpretations and uses as part of the validation process of TOEPAS (Test of Oral English Proficiency for Academic Staff), which is a performance-based test used for oral English certification of lecturers at the University...

  1. Nordic Journal of English Studies

    DEFF Research Database (Denmark)

    2008-01-01

    In difficult economic times, the place of education in the economy comes to the forefront with questions about how effective our programs are in preparing students to become contributing members of the workforce and society. As the discipline of English studies sits at the cross-roads of humanities...... and education for a global society, it has traditionally enjoyed high enrollments and unquestioned value. However, two trends are affecting the position of English studies in the academy: 1) the emergence of communication studies as a discipline and 2) the movement towards education in English as a global...... language across many disciplines in Scandinavia. Because of these movements, the place and purpose for English studies is being called into question. In addition, the ability of an English studies degree in preparing students for the global workforce is also being examined. To address these emergent trends...

  2. Teaching the Dutch how to pronounce English

    NARCIS (Netherlands)

    Hermans, Frans; Sloep, Peter

    2018-01-01

    The Dutch overestimate their English speaking skills. Their pronunciation is not always convincing, and certain pronunciation mistakes are easily recognised as being typical for Dutch speakers of English. Although intelligibility cannot exist without adequate pronunciation, teaching English

  3. Teaching the Dutch how to pronounce English

    NARCIS (Netherlands)

    Frans Hermans; Peter Sloep

    2015-01-01

    The Dutch overestimate their English speaking skills. Their pronunciation is not always convincing and certain pronunciation mistakes are easily recognised as being typical for Dutch speakers of English. Although intelligibility cannot exist without adequate pronunciation, teaching English

  4. More Danish, More English

    DEFF Research Database (Denmark)

    Chopin, Kimberly Renée

    Universities in Denmark are becoming increasingly internationalized, and areincreasingly using English as a language of research, teaching, and administration. At the same time, the Danish language is seen by some as being under threat, and Danish public discourse has focused on what role.......This study investigated the decision making process over time in order to reveal how such language policies would be received in one affected department. Interviews with department teaching staff were carried out both before and after the implementation of the decisions, along with interviews of department...... and faculty level leadership, classroom observations and analysis of written documents. Data was organized using the model provided by Innovation Theory (Henrichsen, 1989), and interpreted using the discursive framework of Nexus Analysis (Scollon & Scollon, 2004).Analysis showed how case department teaching...

  5. English Teachers, Angels & Poverty: Writing on English Curriculum and Pedagogy (Reflections on Editing "English in Australia").

    Science.gov (United States)

    Doecke, Brenton

    2002-01-01

    Explores the cultural politics of writing about English curriculum and pedagogy, focusing on the author's role as the editor of this journal. Describes his role as editor as one of providing a discursive space in which English teachers and literacy educators can begin to write about their work. (SG)

  6. The provision of medical care in English professional football: An update.

    Science.gov (United States)

    Malcolm, Dominic; Scott-Bell, Andrea; Waddington, Ivan

    2017-12-01

    To compare the current methods of appointment, qualifications and occupational experience of club doctors and physiotherapists in English professional football with (i) those outlined in a study published in 1999, and (ii) Football Association (FA) medical regulations. Qualitative. Postal questionnaire survey of (head) doctors and physiotherapists at each of the clubs in the English Premiership, Championship and Football Leagues 1 and 2. Response rates of 35.8% and 45.6% respectively were obtained. The majority of football club doctors are GPs who have sports medicine qualifications and relevant occupational experience. Time commitments vary from full time to a few hours per week. Most are appointed through personal contacts rather than job advertisements and/or interview. Almost all football clubs have a chartered physiotherapist, many of whom have a postgraduate qualification. They work full time and long hours. Most are appointed through personal contacts rather than job advertisements. They are frequently interviewed but not always by someone qualified to judge their professional expertise. Football club medical provision has become more extensive and increasingly professional over the last 10-20years, with better qualified, more career-oriented and more formally contracted staff. It is likely that clinical autonomy has subsequently increased. However recruitment procedures still need to be improved, especially in relation to advertising vacancies, interviewing candidates, and including medical personnel on interview panels. In two aspects clubs appear not to be compliant with current FA medical regulations. Copyright © 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  7. Human serum levels of fetal antigen 1 (FA1/Dlk1) increase with obesity, are negatively associated with insulin sensitivity and modulate inflammation in vitro

    DEFF Research Database (Denmark)

    Chacón, M R; Miranda, M; Jensen, C H

    2008-01-01

    in the context of obesity and insulin sensitivity (S(i)); and n=61 severely obese women before and after bariatric surgery. The response in vitro to FA1 protein on human cell lines of monocytes, preadipocytes and mature adipocytes was studied. MEASUREMENTS: Anthropometrical parameters: body mass index, waist...... levels. In severe obesity, serum levels of FA1 decreased 1.4-fold 6 months after bariatric surgery. In vitro assays with FA1 protein on human monocytes and adipocytes cell lines modified the expression of pro-inflammatory cytokines and adipokines (tumor necrosis factor-alpha (TNFalpha), monocyte...

  8. Effective instruction for English learners.

    Science.gov (United States)

    Calderón, Margarita; Slavin, Robert; Sánchez, Marta

    2011-01-01

    The fastest-growing student population in U.S. schools today is children of immigrants, half of whom do not speak English fluently and are thus labeled English learners. Although the federal government requires school districts to provide services to English learners, it offers states no policies to follow in identifying, assessing, placing, or instructing them. Margarita Calderón, Robert Slavin, and Marta Sánchez identify the elements of effective instruction and review a variety of successful program models. During 2007-08, more than 5.3 million English learners made up 10.6 percent of the nation's K-12 public school enrollment. Wide and persistent achievement disparities between these English learners and English-proficient students show clearly, say the authors, that schools must address the language, literacy, and academic needs of English learners more effectively. Researchers have fiercely debated the merits of bilingual and English-only reading instruction. In elementary schools, English learners commonly receive thirty minutes of English as a Second Language (ESL) instruction but attend general education classes for the rest of the day, usually with teachers who are unprepared to teach them. Though English learners have strikingly diverse levels of skills, in high school they are typically lumped together, with one teacher to address their widely varying needs. These in-school factors contribute to the achievement disparities. Based on the studies presented here, Calderón, Slavin, and Sánchez assert that the quality of instruction is what matters most in educating English learners. They highlight comprehensive reform models, as well as individual components of these models: school structures and leadership; language and literacy instruction; integration of language, literacy, and content instruction in secondary schools; cooperative learning; professional development; parent and family support teams; tutoring; and monitoring implementation and outcomes

  9. Intégration des TIC par les enseignants : premiers résultats d’une enquête suisse

    Directory of Open Access Journals (Sweden)

    Stéphanie Heer

    2006-01-01

    Full Text Available Cet article propose tout d’abord un état de la littérature scientifique dans les domaines de l’intégration et de la formation aux TIC dans la pratique enseignante. Dans une deuxième partie sont présentés les premiers résultats d’une enquête menée sur l’intégration des TIC dans le système scolaire du canton du Jura en Suisse. L’article se termine par la présentation des premières conclusions de cette recherche et une discussion sur les opportunités pédagogiques qu’ouvrent les TIC pour les enseignants débutants.

  10. Le premier élément du patrimoine maritime de Saint-Pierre-et-Miquelon protégé au titre des monuments historiques

    Directory of Open Access Journals (Sweden)

    Herveline Delhumeau

    2009-05-01

    Full Text Available Ymac a été classé par arrêté du 14 février 2008 au titre des monuments historiques en raison de l’intérêt ethnologique lié à sa fonction de bateau-pilote. (fig. n° 1Figure 1Ymac, ex-Radar III. Photographie après 2003. © Yannick Lafourcade.Construit en 1965 à Mavilette (Nouvelle-Ecosse, Canada par le chantier Alfred Boudreau, ce bateau traditionnel de pêche à coque en bois avait été initialement armé pour la pêche aux poissons plats par Alex Doucet, d’où son premier nom Alex D. Après avoir p...

  11. Les premiers temps de l'architecture en briques au nord des Alpes : la question de l'origine cistercienne vue des Pays-Bas

    OpenAIRE

    Lehouck, Alexander

    2017-01-01

    L'argile est l'une des plus vieilles matières premières pour la fabrication de matériaux de construction. La chute de l'Empire romain a marqué la fin de l'utilisation de la brique au nord des Alpes. La brique ne ressurgit véritablement qu' à partir de la deuxième moitié du XIIe s. et de la première moitié du XIIe s.; dans la deuxième moitié du XIIIe s., la brique était devenue le matériau de construction le plus utilisé. Dans cet article, nous discutons les données concernant les premiers ...

  12. Technical and tactical training team «Helios» Kharkiv in the first round of 23 Ukrainian football championship in the premier league 2013–2014

    Directory of Open Access Journals (Sweden)

    Rebaz Sleman

    2014-10-01

    Full Text Available Purpose: to define the characteristics of the model command of technical and tactical training team participating in the Ukrainian Premier League First League. Material and Methods: the research was conducted using the method of peer review. The experts were involved 5 specialists football. Results: the mean values for the analyzed variables in 10 games. The various technical and tactical actions and their percentage in the overall structure of the game team statistics for 20 games, as well as some indicators of team play "Helios" Kharkov. Conclusions: the obtained quantitative and qualitative indicators (coefficient of marriage as a team on the technical and tactical actions, as well as separately for each technical and tactical reception. The performances allow you to make adjustments to the training process this command to improve sportsmanship.

  13. See you at the match: Motivation for sport consumption and intrinsic psychological reward of premier football league spectators in South Africa

    Directory of Open Access Journals (Sweden)

    Frederick W. Stander

    2016-04-01

    Full Text Available Orientation: Local football contributes significantly to the social- and economic welfare of South Africa through its spectators. Understanding the motives and experiences of football spectators could provide opportunities for capitalising on football as revenue stream feeding the South African economy. Research purpose: To investigate how motives for sport consumption predict intrinsic psychological reward of South African premier league football spectators. Motivation for the study: Sport - particularly football - is an untapped resource for stimulating economic development and growth through its consumers. Spectators, who often experience their investment in the sport as deeply rewarding and meaningful, should participate more frequently in purchasing products or services associated with the sport. Through understanding the motives for sport consumption of South African premier league football spectators and the impact of these motives on intrinsic psychological reward experiences, football clubs are able to provide a targeted experience or service to spectators in order to further stimulate economic growth. Research design, approach and method: A census sample of 806 football spectators attending various matches at a football stadium in Soweto was drawn. A cross-sectional research design was implemented. This research was exploratory and descriptive. Structural equation modelling was implemented to assess the factor structures of the constructs, to confirm composite reliability of the measures and to assess the structural paths between the variables. Main findings: A predictive model for intrinsic psychological rewards (life satisfaction and meaning through the motivation for sport consumption (individual – and game related factors was confirmed. It was further established that motivation for sport consumption is significantly positively a related to and b associated with the experience of intrinsic psychological reward by South African

  14. See you at the match: Motivation for sport consumption and intrinsic psychological reward of premier football league spectators in South Africa

    Directory of Open Access Journals (Sweden)

    Frederick W. Stander

    2016-04-01

    Full Text Available Orientation: Local football contributes significantly to the social- and economic welfare of South Africa through its spectators. Understanding the motives and experiences of football spectators could provide opportunities for capitalising on football as revenue stream feeding the South African economy. Research purpose: To investigate how motives for sport consumption predict intrinsic psychological reward of South African premier league football spectators. Motivation for the study: Sport - particularly football - is an untapped resource for stimulating economic development and growth through its consumers. Spectators, who often experience their investment in the sport as deeply rewarding and meaningful, should participate more frequently in purchasing products or services associated with the sport. Through understanding the motives for sport consumption of South African premier league football spectators and the impact of these motives on intrinsic psychological reward experiences, football clubs are able to provide a targeted experience or service to spectators in order to further stimulate economic growth. Research design, approach and method: A census sample of 806 football spectators attending various matches at a football stadium in Soweto was drawn. A cross-sectional research design was implemented. This research was exploratory and descriptive. Structural equation modelling was implemented to assess the factor structures of the constructs, to confirm composite reliability of the measures and to assess the structural paths between the variables. Main findings: A predictive model for intrinsic psychological rewards (life satisfaction and meaning through the motivation for sport consumption (individual – and game related factors was confirmed. It was further established that motivation for sport consumption is significantly positively a related to and b associated with the experience of intrinsic psychological reward by South African

  15. Students’ Motivation in Speaking English

    Directory of Open Access Journals (Sweden)

    Mas Darul Ihsan

    2016-05-01

    Full Text Available As the English teacher in the classroom, there will be some problems or conditions need to be accomplished. Teacher will see some of the students are very motivated, motivated or even feeling ignored in studying English. The learners who have contacted with English will find that some features are quite easy and extremely difficult. One of the more complicated problems of second or foreign languages learning and  teaching has been to define and apply the construct of motivation in the classroom. Motivation is a concept without physical reality, we cannot see motivation; we see effort, interest, attitude and desire. For speaking, it is important first to give competence and then performance. Competence is more likely to the extent a communicator is motivated to be so. Motivation is the extent to which a communicator is drawn towards or pushed away from communicating competently in a given context then performed. This is a descriptive  quantitative research. The data obtained from the questionnaire distributed and analyzed to get the result.  The date taken from the students of Muhammadiyah 1 Senior High School Gresik in Easy-Speaking course. The researcher wanted to know the students’ motivation in practicing speaking English in Easy-Speaking course. The results show that 1 the learners effort in practicing speaking English is 56.1 %. 2 The learners’ interest in practicing speaking English is 49.7 %. 3 The learners’ attitude towards practicing speaking English is 59.9 %. 4 The learners’ desire in practicing speaking English is 71.43 %. Then, some suggestions are made: 1 Using media is very important both to increase the learners’ motivation and to give a big opportunity to learners to explore their idea. 2 Giving more variations techniques in teaching and learning process in order do not monotonous. 3 Giving prizes, encouraging and giving extra points for learners who can express their idea by speaking English well. 4 Creating

  16. Is English a dyslexic language?

    Science.gov (United States)

    Spencer, K

    2000-01-01

    McGuinness has suggested that there 'is no diagnosis and no evidence for any special type of reading disorder like dyslexia', and that poor teaching accounts for low levels of English literacy performance, rather than inherent personal deficits. Implicit in this is the assumption that some languages have simple grapheme-phoneme codes in which there is a one-to-one mapping, making them easy to teach and learn, while others have more complicated structures and are more difficult for teachers and students. There is now an increasing number of studies which demonstrate that readers in more transparent orthographies such as Italian, Spanish, Turkish, Greek and German have little difficulty in decoding written words, while English children have many more problems. Increasingly, lack of orthographic transparency in English is seen as having a powerful negative effect on the development of reading skills in English-speaking children. There is evidence that English-speaking children who fail to acquire reading skills may fall into two distinct categories: those who would succeed in languages, other than English, that have greater orthographic consistency; and those who would still have problems even with perfect orthographic transparency. The first, larger, group is let down by the interaction of poor teaching methods and an incomprehensible system of orthography. The present study examines word factors associated with poor spelling and reading that have been identified. Three factors account for the relative ease with which pupils can spell words: frequency of the word in the English language; length of the word; and the presence of 'tricky' letters or letter combinations. Data are presented illustrating the predictive model of spelling and reading which enables word difficulty to be calculated from the characteristics of English words. The implications the model has for teaching and learning English are elaborated, with reference to the possible benefits to be derived

  17. Non-Native & Native English Teachers

    Directory of Open Access Journals (Sweden)

    İrfan Tosuncuoglu

    2017-12-01

    Full Text Available In many countries the primary (mother tongue language is not English but there is a great demand for English language teachers all over the world. The demand in this field is try to be filled largely by non-native English speaking teachers who have learned English in the country or abroad, or from another non native English peaking teachers. In some countries, particularly those where English speaking is a a sign of status, the students prefer to learn English from a native English speaker. The perception is that a non-native English speaking teacher is a less authentic teacher than a native English speaker and their instruction is not satifactory in some ways. This paper will try to examine the literature to explore whether there is a difference in instructional effectiveness between NNESTs and native English teachers.

  18. English Grammar Workbook For Dummies

    CERN Document Server

    O'Sullivan, Nuala

    2010-01-01

    English Grammar Workbook For Dummies, UK Edition is grammar First Aid for anyone wanting to perfect their English and develop the practical skills needed to write and speak correctly. Each chapter focuses on key grammatical principles, with easy-to-follow theory and examples as well as practice questions and explanations. From verbs, prepositions and tenses, to style, expressions and tricky word traps, this hands-on workbook is essential for both beginners looking to learn and practise the basics of English grammar, and those who want to brush up skills they already have - quickly, easily, and

  19. Life after oral English certification

    DEFF Research Database (Denmark)

    Dimova, Slobodanka

    2017-01-01

    Internationalization of higher education has resulted in rapid developments of English-medium instruction (EMI) courses in non-Anglophone countries in Europe and Asia. Due to the growing concerns about lecturers' ability to teach in English, several European universities have implemented policies...... for internal assessment of lecturers' English proficiency to ensure the quality of teaching in EMI programs. However, research on the measured construct and the reliability and the validity of these assessments remains scarce. Based on interviews with tested university lecturers and formative feedback analysis...

  20. Summer Oral Expression English course

    CERN Multimedia

    2012-01-01

    An English Oral Expression course will take place this summer from 20 August to 29 September.   Schedule: to be determined (2 sessions of 2 hours per week). Please note that this course is for learners who have a good knowledge of English (CERN level 7 upwards). If you are interested in following this course, please enroll through this link. Please be sure to indicate your planned absences in the comments field so we can schedule the course. If you need more information please send a message to English.training@cern.ch

  1. Summer Oral Expression English course

    CERN Multimedia

    2012-01-01

    An English Oral Expression course will take place this summer at some time between 25 June and 28 September. The exact dates will be decided according to the preferences of the students.   Schedule: to be determined (2 sessions of 2 hours per week). Please note that this course is for learners who have a good knowledge of English (CERN level 7 upwards). If you are interested in following this course, please enroll through this link. Please be sure to indicate your planned absences in the comments field so we can schedule the course. If you need more information please send a message to English.training@cern.ch

  2. Summer Oral Expression English course

    CERN Multimedia

    2013-01-01

    An English Oral Expression course will take place this summer at some time between August 19 and October 4.   Schedule: to be determined (2 sessions of 2 hours per week). Please note that this course is for learners who have a good knowledge of English (CERN level 7 upwards). If you are interested in following this course, please enroll through this link. Please be sure to indicate your planned absences in the comments field so we can schedule the course. If you need more information please send a message to English.training@cern.ch.

  3. Working in English student's book

    CERN Document Server

    Jones, Leo

    2001-01-01

    Working In English is a comprehensive course for Business English learners from Leo Jones, co-author of the successful New International Business English course. The core course comprises 40 one-hour units, focusing on thye practical day-to-day activities that all business people are involved in, and organised into seven modules. It is supplemented by extra activities from the Teacher's Book to offer maximum flexibility. The accompanying Video contains specially filmed documentary sequences, made in Europe and the USA, that relate to the themes of the modules and provide authentic input to the course.

  4. O jornalismo televisivo nas redes sociais. As relações comunicacionais entre o mito e o fã.

    Directory of Open Access Journals (Sweden)

    Paulo Eduardo Cajazeira

    2015-11-01

    do telejornal na fanpage, a fim de evidenciar as motivações do seguidor (fã em participar do ambiente virtual do telejornal no Facebook.  Cette étude comparative portugo-brésilienne, réalisée entre 2013 et 2014, dans le cadre du Laboratoire de communication et des contenus en ligne de l’Université da Beira interior (Portugal explore les relations entre le journalisme télévisé (entendu comme mythe et son public (de fans au travers des réseaux sociaux sur internet. Cette recherche actuelle s’ancre dans une perspective longue qui vise à comprendre les changements survenus dans le système d’interactions entre les acteurs (le public/le journal télévisé/le milieu médiatique au cours du passage de l’analogique au digital. Ce travail s’organise comme suit : un premier temps aborde le système d’interactions entre le public et le journal télévisé ; un second temps présente le corpus de la recherche, en mettant en évidence la relation entre le public (de fans et le journal télévisé (entendu comme mythe au travers des réseaux socio-numériques, et détaille la méthodologie et les résultats de recherche. Ce texte repose sur un travail autour des concepts qui ont émergé de la partie empirique de l’étude : la convergence des audiences, la culture fan et le simulacre de représentation des acteurs dans le journalisme télévisuel et la société médiatisée à travers la pluralité des écrans. Le texte présente finalement les conclusions de la recherche. Dans la partie empirique, nous avons développé l’accompagnement des interactions avec le public dans les fanpages des journaux télévisés Edição da Manhã (SICTV/Portugal et de Bom Dia Brasil (TV Globo/Brésil, du 2 septembre au 31 décembre 2013, sur Facebook. L’objectif était de vérifier les relations de communication entre les acteurs du journal télévisé. Cette phase a été couplée à une visite

  5. International English teachers' perceptions of English as an international language

    OpenAIRE

    Altun-Evci, Hatice

    2010-01-01

    Ankara : The Department of Teaching English as a Foreign Language, Bilkent University, 2010. Thesis (Master's) -- Bilkent University, 2010. Includes bibliographical references leaves 117-126. English as an International Language (EIL) and its implications for ELT have been keenly debated throughout the last two decades. Many researchers have in some depth elaborated on the issues of identity and voice, linguistic imperialism, and the importance of non-native speakers and the...

  6. NEEDS ANALYSIS OF ENGLISH LITERATURE STUDENTS IN ENGLISH ORAL COMMUNICATION

    Directory of Open Access Journals (Sweden)

    Angga Maulana

    2017-12-01

    Full Text Available The purpose of this study is to identify factual information about the needs of students of English Literature in the activities and supporting factors of oral communication by using English, whether linguistic and non-linguistic, and analyzing the difficulties of the situation of oral communication of English Literature students using English. This research uses descriptive method. Data collection is done through two stages: the questionnaire and the interview, followed by the review of someliteratures. The results of this study indicate that in general the students of English Literature feel that participating in a formal discussion is more important than the informal. While in terms of ability in the oral communication activity, generally students mastered informal communication activities. In terms of linguistic factors, the choice of vocabularies, and good and correct sentences are considered very important, although they only feel quite capable in it. It is also found that talking with self-confidence, having proper English pronunciation and mastering the topic of conversation become the important non-linguistic factors. The same thing does not happen on loudness and facial mimic. In general, students feel it is not important enough to master. Regarding situations that facilitate students in oral communication in English, they generally feel that well preparation, self-confidence, and mastery over vocabulary and what is being discussed becomes an easier factor. Different things revealed by most students about the difficult vocabulary and the lack of preparation in oral communication. It is difficult. As for things that require improvement, students generally feel that the confidence and the amount of vocabulary that is mastered should be improved in order to improve the quality of oral communication in English.

  7. English-language learners’ problem solving in Spanish versus English

    OpenAIRE

    Ambrose, Rebecca; Molina, Marta

    2010-01-01

    To explore the role of language in English Language Learners (ELLs)´ problem solving, we compare the performance of a group of Latino first graders when working in Spanish and in English on two equivalent sets of story problems. We contrast our results with others from previous studies with bilingual and monolinguals children by focusing on students´ performance in problems with the same semantic structure. This comparison leads us to discuss some factors influencing students´ problem solving...

  8. Learning Strategies in Alleviating English Writing Anxiety for English Language Learners (ELLs) with Limited English Proficiency (LEP)

    Science.gov (United States)

    Wu, Chia-Pei; Lin, Huey-Ju

    2016-01-01

    This study utilized the Oxford Strategy Inventory for Language Learning (SILL) and an English writing anxiety scale to examine the relationship between learning strategies and English writing anxiety in 102 university-level English language learners (ELLs) with Limited English Proficiency (LEP) in a university in Taiwan. Kruskal Wallis Test…

  9. Bacterial transformation: ComFA is a DNA-dependent ATPase that forms complexes with ComFC and DprA.

    Science.gov (United States)

    Diallo, Amy; Foster, Hannah R; Gromek, Katarzyna A; Perry, Thomas N; Dujeancourt, Annick; Krasteva, Petya V; Gubellini, Francesca; Falbel, Tanya G; Burton, Briana M; Fronzes, Rémi

    2017-09-01

    Pneumococcal natural transformation contributes to genomic plasticity, antibiotic resistance development and vaccine escape. Streptococcus pneumoniae, like many other naturally transformable species, has evolved sophisticated protein machinery for the binding and uptake of DNA. Two proteins encoded by the comF operon, ComFA and ComFC, are involved in transformation but their exact molecular roles remain unknown. In this study, we provide experimental evidence that ComFA binds to single stranded DNA (ssDNA) and has ssDNA-dependent ATPase activity. We show that both ComFA and ComFC are essential for the transformation process in pneumococci. Moreover, we show that these proteins interact with each other and with other proteins involved in homologous recombination, such as DprA, thus placing the ComFA-ComFC duo at the interface between DNA uptake and DNA recombination during transformation. © 2017 John Wiley & Sons Ltd.

  10. Derivation of elastic stiffness formula for leaf type HDS and conceptual design of leaf type HDS of SMART FA

    Energy Technology Data Exchange (ETDEWEB)

    Song, Kee Nam; Kang, Heung Seok; Yoon, Kyung Ho; Suh, Jung Min; Lee, Jin Seok

    1997-12-01

    Based on the strain energy method and Euler beam theory, an elastic stiffness formula for the leaf type HDS, now widely used as the holddown spring for the FA of Westinghouse type PWRs, has been derived. Through comparisons with the characteristic test results of the test produced HDSs, it has been found that the derived formula is useful to reliably estimate an elastic stiffness with material properties and the geometric data of an HDS. Through sensitivity analysis of HDS`s elastic stiffness, the elastic stiffness sensitivity with respect to different design variables was identified, as well as the design variables having remarkable sensitivity. In addition, finite element analysis using surface-to-surface contact elements on the contact surface between the leaves shows that the analysis results are in good agreement with the elastic stiffness determined from the derived formula. It is therefore expected that the finite element model and the analysis method will be useful in the analysis of the elasto-plastic behavior of the leaf type HDS in the future. To both reduce the cobalt content, which is considered to be the source of radioactive contamination in the reactor core, and to design the HDS to meet the holddown requirements of the SMART FA, a conceptual design for the HDS of the SMART FA has been performed through two analyses of the elastic characteristics of the HDS : the possibility of substitution of the leaf spring`s material from Inconel 718 to Zircaloy and the effects on the HDS`s elastic characteristics according to the variation of leaf thickness and the number of leaves composing the HDS. (author). 34 refs., 33 tabs., 37 figs.

  11. Façade insulation retrofitting policy implementation process and its effects on health equity determinants: A realist review

    International Nuclear Information System (INIS)

    Camprubí, Lluís; Malmusi, Davide; Mehdipanah, Roshanak

    2016-01-01

    Fuel poverty and cold housing constitute a significant public health problem. Energy efficiency interventions, such as façade retrofitting, address the problem from a structural and long-term perspective. Despite evidence of the health benefits of insulation, little is known about the political and social contexts that contribute to social inequalities in receiving and experiencing health benefits from these interventions. We used a realist review methodology to better understand the mechanisms that explain how and why variations across different social groups appear in receiving energy efficiency façade retrofitting interventions and in their impact on health determinants. We considered the four stages of the policy implementation framework: public policy approach; policy; receiving intervention and impact on health determinants. We found strong evidence that certain social groups (low-income, renters, elderly) suffering most from fuel poverty, experience more barriers for undertaking a building retrofitting (due to factors such as upfront costs, “presentism” thinking, split incentives, disruption and lack of control), and that some public policies on housing energy efficiency may exacerbate these inequalities. This can be avoided if such policies specifically aim at tackling fuel poverty or social inequities, are completely free to users, target the most affected groups and are adapted to their needs. - Highlights: •Health benefits of housing façade insulation more pronounced in fuel poor groups. •Social groups suffering most from fuel poverty least likely to undergo insulation. •Energy efficiency policies focused solely on CO 2 reduction may increase inequalities. •Split Incentives and “Take-Back” effect show socioeconomic and contextual variability. •Universal policies without targeting increase inequalities in retrofitting uptake.

  12. Metabolic Interaction between Anthocyanin and Lignin Biosynthesis Is Associated with Peroxidase FaPRX27 in Strawberry Fruit1[W

    Science.gov (United States)

    Ring, Ludwig; Yeh, Su-Ying; Hücherig, Stephanie; Hoffmann, Thomas; Blanco-Portales, Rosario; Fouche, Mathieu; Villatoro, Carmen; Denoyes, Béatrice; Monfort, Amparo; Caballero, José Luis; Muñoz-Blanco, Juan; Gershenson, Jonathan; Schwab, Wilfried

    2013-01-01

    Plant phenolics have drawn increasing attention due to their potential nutritional benefits. Although the basic reactions of the phenolics biosynthetic pathways in plants have been intensively analyzed, the regulation of their accumulation and flux through the pathway is not that well established. The aim of this study was to use a strawberry (Fragaria × ananassa) microarray to investigate gene expression patterns associated with the accumulation of phenylpropanoids, flavonoids, and anthocyanins in strawberry fruit. An examination of the transcriptome, coupled with metabolite profiling data from different commercial varieties, was undertaken to identify genes whose expression correlated with altered phenolics composition. Seventeen comparative microarray analyses revealed 15 genes that were differentially (more than 200-fold) expressed in phenolics-rich versus phenolics-poor varieties. The results were validated by heterologous expression of the peroxidase FaPRX27 gene, which showed the highest altered expression level (more than 900-fold). The encoded protein was functionally characterized and is assumed to be involved in lignin formation during strawberry fruit ripening. Quantitative trait locus analysis indicated that the genomic region of FaPRX27 is associated with the fruit color trait. Down-regulation of the CHALCONE SYNTHASE gene and concomitant induction of FaPRX27 expression diverted the flux from anthocyanins to lignin. The results highlight the competition of the different phenolics pathways for their common precursors. The list of the 15 candidates provides new genes that are likely to impact polyphenol accumulation in strawberry fruit and could be used to develop molecular markers to select phenolics-rich germplasm. PMID:23835409

  13. English romantic verse drama

    Directory of Open Access Journals (Sweden)

    Andrejević Ana

    2007-01-01

    Full Text Available The changes in the nature of drama and particularly the historical decline of drama as a literary form, in the eighteenth and early nineteenth centuries correspond directly to the crisis of social class, which involved the transition - in England - from an aristocratic to a middle - class social order. In the framework of those social and also historical changes in Europe, English romantic verse drama gives the answer to the social reality through the vision of free and individualized characters. The pain, intensive sensitivity of the romantics, irrationality of the sublime ideas and the poetic style of the blank verse are the main characteristics of these dramas which diachronically influenced this genre in Victorian and modern era. Wordsworth, Coleridge, Shelley, Byron and others put the passionate individualist with his ideas of freedom and love in the center of dramatic action. Byron's dramas stand as the greatest and most articulate voice of Romantic drama. Whatever its aesthetic merits or shortcomings, and however traditional scholars may situate it within the frames of literary history Romantic drama occupies a critically important position in the social history of Romanticism but it also represents an important link in the development of verse drama from the Shakespeare to the modern age.

  14. Teaching English Through Literature

    Directory of Open Access Journals (Sweden)

    Murat Hişmanoğlu

    2005-04-01

    Full Text Available This paper aims at emphasizing the use of literature as a popular technique for teaching both basiclanguage skills (i.e. reading, writing, listening and speaking and language areas (i.e. vocabulary,grammar and pronunciation in our times. Reasons for using literary texts in foreign language classroomand main criteria for selecting suitable literary texts in foreign language classes are stressed so as tomake the reader familiar with the underlying reasons and criteria for language teachers’ using andselecting literary texts. Moreover, literature and the teaching of language skills, benefits of differentgenres of literature (i.e. poetry, short fiction, drama and novel to language teaching and some problemsencountered by language teachers within the area of teaching English through literature (i.e. lack ofpreparation in the area of literature teaching in TESL / TEFL programs, absence of clear-cut objectivesdefining the role of literature in ESL / EFL, language teachers’ not having the background and trainingin literature, lack of pedagogically-designed appropriate materials that can be used by language teachersin a classroom context are taken into account.

  15. English and French courses

    CERN Document Server

    2014-01-01

    If one of your New Year’s resolutions is to learn a language, there is no excuse anymore!   You can attend one of our English or French courses and you can practise the language with a tandem partner! General and Professional French Courses The next session will take place from 27 January to 4 April 2014. These courses are open to all persons working on the CERN site, and to their spouses. Oral Expression This course is aimed at students with a good knowledge of French who want to enhance their speaking skills. Speaking activities will include discussions, meeting simulations, role-plays etc. The next session will take place from 27 January to 4 April 2014. Writing professional documents in French These courses are designed for non-French speakers with a very good standard of spoken French. The next session will take place from 27 January to 4 April 2014. Cours d’anglais général et professionnel La prochaine session se déroulera du 3 mars a...

  16. Modeling a Naturally Ventilated Double Skin Façade with a Building Thermal Simulation Program

    DEFF Research Database (Denmark)

    Jensen, Rasmus Lund; Kalyanova, Olena; Heiselberg, Per

    2008-01-01

    to predict. This is manly due to the very transient and complex air flow in the naturally ventilated double skin façade cavity. In this paper the modelling of the DSF using a thermal simulation program, BSim, is discussed. The simulations are based on the measured weather boundary conditions......, and the simulation results are compared to the measurement results like energy consumption for cooling, air temperature, temperature gradient and mass flow rate in the DSF cavity, etc. Details about the measurements are reported in \\Kalyanova et al. 2008\\. The thermal simulation program does not at the moment...

  17. FMRFamide-related peptides (FaRPs): A new family of peptides from amphibian defensive skin secretions

    DEFF Research Database (Denmark)

    Wang, Lei; Smyth, Anita; Johnsen, Anders

    2009-01-01

    amide (EF-10 amide), from the defensive skin secretions of two different species of African hyperoliid frogs, Kassina maculata and Phylictimantis verrucosus, respectively. These represent the first canonical FMRF amide-related peptides (FaRPs) from a vertebrate source. The cDNA encoding IF-8 amide...... was cloned from a skin secretion library and found to contain a single copy of the peptide located at the C-terminus of a 58 amino acid residue open-reading frame. These data extend the potential targets of the defensive arsenal of amphibian tegumental secretions to parasitic/predatory invertebrates...

  18. International Psychometric Validation of an EORTC Quality of Life Module Measuring Cancer Related Fatigue (EORTC QLQ-FA12).

    Science.gov (United States)

    Weis, Joachim; Tomaszewski, Krzysztof A; Hammerlid, Eva; Ignacio Arraras, Juan; Conroy, Thierry; Lanceley, Anne; Schmidt, Heike; Wirtz, Markus; Singer, Susanne; Pinto, Monica; Alm El-Din, Mohamed; Compter, Inge; Holzner, Bernhard; Hofmeister, Dirk; Chie, Wei-Chu; Czeladzki, Marek; Harle, Amelie; Jones, Louise; Ritter, Sabrina; Flechtner, Hans-Henning; Bottomley, Andrew

    2017-05-01

    The European Organisation for Research and Treatment of Cancer (EORTC) Group has developed a new multidimensional instrument measuring cancer-related fatigue to be used in conjunction with the quality of life core questionnaire (EORTC QLQ-C30). The module EORTC QLQ-FA13 assesses physical, cognitive, and emotional aspects of cancer-related fatigue. The methodology follows the EORTC guidelines for phase IV validation of modules. This paper focuses on the results of the psychometric validation of the factorial structure of the module. For validation and cross-validation confirmatory factor analysis (maximum likelihood estimation), intraclass correlation and Cronbach alpha for internal consistency were employed. The study involved an international multicenter collaboration of 11 European and non-European countries. A total of 946 patients with various tumor diagnoses were enrolled. Based on the confirmatory factor analysis, we could approve the three-dimensional structure of the module. Removing one item and reassigning the factorial mapping of another item resulted in the EORTC QLQ-FA12. For the revised scale, we found evidence supporting good local (indicator reliability ≥ 0.60, factor reliability ≥ 0.82) and global model fit (GFI t1|t2 = 0.965/0.957, CFI t1|t2 = 0.976/0.972, RMSEA t1|t2 = 0.060/0.069) for both measurement points. For each scale, test-retest reliability proved to be very good (intraclass correlation: R t1-t2 = 0.905-0.921) and internal consistency proved to be good to high (Cronbach alpha = .79-.90). Based on the former phase III module, the multidimensional structure was revised as a phase IV module (EORTC FA12) with an improved scale structure. For a comprehensive validation of the EORTC FA12, further aspects of convergent and divergent validity as well as sensitivity to change should be determined. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  19. Torroja Institute, the historic building: conservation and characteristics of the materials of its façades

    OpenAIRE

    Luxán, M. P.; Gaspar, D.; Sotolongo, R.; Solesio, M. T.; Dorrego, F.

    1999-01-01

    The "Instituto de Ciencias de la Construcción" building is one of the most singular engineering design done by Eduardo Torroja: it was started in 1951. This study focused on the Institute façade-building materials has been carried out in the 100th anniversary of his birth. The analysis has revealed that the design of the original project has been of a great importance for the good conservation of the external walls. The pointing mortar characterization of its brick...

  20. Evaluation of Carbohydrate-Derived Fulvic Acid (CHD-FA) as a Topical Broad-Spectrum Antimicrobial for Drug-Resistant Wound Infections

    Science.gov (United States)

    2016-10-01

    of Carbohydrate-Derived Fulvic Acid (CHD-FA) as a Topical Broad- Spectrum Antimicrobial for Drug- Resistant Wound Infections 5b. GRANT NUMBER 5c...demonstrated the antimicrobial properties of Carbohydrate-Derived Fulvic Acid (CHD-FA) against a broad collection of multi-drug resistant bacterial and...spectrum antimicrobial for drug- resistant wound infections) at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2014

  1. Business Writing in Freshman English.

    Science.gov (United States)

    Larmouth, Donald W.

    1980-01-01

    Suggests incorporating business writing into a freshman English course. Outlines three writing and research assignments: a financial status memorandum, a management analysis report, and an evaluation of applicants for a position at a university. (TJ)

  2. Design of an effective bifunctional catalyst organotriphosphonic acid-functionalized ferric alginate (ATMP-FA) and optimization by Box-Behnken model for biodiesel esterification synthesis of oleic acid over ATMP-FA.

    Science.gov (United States)

    Liu, Wei; Yin, Ping; Liu, Xiguang; Qu, Rongjun

    2014-12-01

    Biodiesel production has become an intense research area because of rapidly depleting energy reserves and increasing petroleum prices together with environmental concerns. This paper focused on the optimization of the catalytic performance in the esterification reaction of oleic acid for biodiesel production over the bifunctional catalyst organotriphosphonic acid-functionalized ferric alginate ATMP-FA. The reaction parameters including catalyst amount, ethanol to oleic acid molar ratio and reaction temperature have been optimized by response surface methodology (RSM) using the Box-Behnken model. It was found that the reaction temperature was the most significant factor, and the best conversion ratio of oleic acid could reach 93.17% under the reaction conditions with 9.53% of catalyst amount and 8.62:1 of ethanol to oleic acid molar ratio at 91.0 °C. The research results show that two catalytic species could work cooperatively to promote the esterification reaction, and the bifunctional ATMP-FA is a potential catalyst for biodiesel production. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Glucomannan or Glucomannan Plus Spirulina-Enriched Squid-Surimi Diets Reduce Histological Damage to Liver and Heart in Zucker fa/fa Rats Fed a Cholesterol-Enriched and Non-Cholesterol-Enriched Atherogenic Diet.

    Science.gov (United States)

    Vázquez-Velasco, Miguel; González-Torres, Laura; García-Fernández, Rosa A; Méndez, María Teresa; Bastida, Sara; Benedí, Juana; González-Muñoz, María José; Sánchez-Muniz, Francisco J

    2017-06-01

    Glucomannan-enriched squid surimi improves cholesterolemia and liver antioxidant status. The effect of squid surimi enriched with glucomannan or glucomannan plus spirulina on liver and heart structures and cell damage markers was tested in fa/fa rats fed highly saturated-hyper-energetic diets. Animals were fed 70% AIN-93M rodent diet plus six versions of 30% squid surimi for 7 weeks: control (C), glucomannan (G), and glucomannan plus spirulina (GS). The cholesterol-control (HC), cholesterol-glucomannan (HG), and cholesterol-glucomannan plus spirulina (HGS) groups were given similar diets that were enriched with 2% cholesterol and 0.4% cholic acid. G and GS diets versus C diet significantly inhibited weight gain and lowered plasma alanine aminotransferase and aspartate aminotransferase, liver steatosis, lipogranulomas, and total inflammation and alteration scores. The hypercholesterolemic agent significantly increased the harmful effects of the C diet. Liver weight, the hepatosomatic index, all damage markers, and total histological scoring rose for HC versus C (at least P spirulina were observed except for the total liver alteration score. In conclusion, glucomannan and glucomannan plus spirulina blocked the highly saturated-hyper-energetic diet negative effects both with and without added cholesterol. Results suggest the usefulness of including these functional ingredients in fish products.

  4. GLUCOMANNAN AND GLUCOMANNAN PLUS SPIRULINA-ENRICHED SQUID-SURIMI ADDED TO HIGH SATURATED DIET AFFECT GLYCEMIA, PLASMA AND ADIPOSE LEPTIN AND ADIPONECTIN LEVELS IN GROWING FA/FA RATS.

    Science.gov (United States)

    Vázquez-Velasco, Miguel; González-Torres, Laura; Méndez, María Teresa; Bastida, Sara; Benedí, Juana; González-Muñoz, M José; Sánchez-Muniz, Francisco J

    2015-12-01

    Type 2 diabetes is a very prevalent chronic disease. Among dietary factors for its prevention and treatment, interest has grown in satiating fibre (konjac glucomannan) and spirulina. Our previous studies suggest that glucomannan itself and/or in conjunction to spirulina displayed hypolipemic and antioxidant effects when incorporated to squid surimi as functional ingredients. The present study aims to determine whether glucomannan- enriched or glucomannan plus spirulina-enriched squid-surimi improve plasma glucose and insulin levels in Zucker fa/fa rats fed a high saturated fat diet. Twenty four growing rats, divided into three groups, were given modified AIN-93M diets for seven weeks: 30% squid-surimi control diet (C), 30% glucomannan-enriched squid-surimi diet (G) and 30% glucomannan plus spirulina-enriched squid-surimi diet (GS). All rats became hyperglycemics and hyperinsulinemics, but G and GS diets induced significantly lower glucose levels (20%; p Spirulina inclusion increased insulin availability. Although results are promising, the utility of consuming glucomannan surimis as part of usual diets demands future studies. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  5. Summer Oral Expression English Course

    CERN Multimedia

    HR Department

    2011-01-01

    An English Oral Expression course will take place between 15 August and 30 September 2011. Schedule: to be determined (2 sessions of 2 hours per week). Please note that this course is for learners who have a good knowledge of English (CERN level 7 upwards). If you are interested in following this course, please enrol here. Or contact: Kerstin FUHRMEISTER (70896) Tessa OSBORNE (72957)  

  6. Molecular regulation and physiological functions of a novel FaHsfA2c cloned from tall fescue conferring plant tolerance to heat stress.

    Science.gov (United States)

    Wang, Xiuyun; Huang, Wanlu; Liu, Jun; Yang, Zhimin; Huang, Bingru

    2017-02-01

    Heat stress transcription factors (HSFs) compose a large gene family, and different members play differential roles in regulating plant responses to abiotic stress. The objectives of this study were to identify and characterize an A2-type HSF, FaHsfA2c, in a cool-season perennial grass tall fescue (Festuca arundinacea Schreb.) for its association with heat tolerance and to determine the underlying physiological functions and regulatory mechanisms of FaHsfA2c imparting plant tolerance to heat stress. FaHsfA2c was localized in nucleus and exhibited a rapid transcriptional increase in leaves and roots during early phase of heat stress. Ectopic expression of FaHsfA2c improved basal and acquired thermotolerance in wild-type Arabidopsis and also restored heat-sensitive deficiency of hsfa2 mutant. Overexpression of FaHsfA2c in tall fescue enhanced plant tolerance to heat by triggering transcriptional regulation of heat-protective gene expression, improving photosynthetic capacity and maintaining plant growth under heat stress. Our results indicated that FaHsfA2c acted as a positive regulator conferring thermotolerance improvement in Arabidopsis and tall fescue, and it could be potentially used as a candidate gene for genetic modification and molecular breeding to develop heat-tolerant cool-season grass species. © 2016 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  7. Humor and Satire in the English Classroom.

    Science.gov (United States)

    Donelson, Kenneth, Ed.

    1973-01-01

    According to the "Arizona English Bulletin" (AEB), not enough attention is given to humor or satire in high school English classes. AEB suggests that if the English class is a place for bringing reality into the curriculum, humor must become a part of the total English program. Featured in this issue are 25 essays on various aspects of…

  8. Teaching English as an International Language

    Science.gov (United States)

    Selvi, A. F.; Yazan, B.

    2013-01-01

    English has unquestionably become a global phenomenon, generating a fundamental discussion of EIL pedagogy for English language teaching practitioners around the world. Teaching English as an International Language captures this important moment in the history of English language teaching. Readers will find an accessible introduction to the past,…

  9. English Teaching Profile: Yemen Arab Republic.

    Science.gov (United States)

    British Council, London (England). English Language and Literature Div.

    A description of the role and status of the English language in the Yemen Arab Republic begins with a general statement concerning the distribution of English speakers and the use of English language materials. Subsequent sections outline: (1) the use and status of English within the educational system at all levels, including teacher education;…

  10. Globalization and English in Chinese Higher Education

    Science.gov (United States)

    Chang, Junyue

    2006-01-01

    This paper sets China's education of English majors within the changing global and national context. It examines the impact of accelerating globalisation and the rise of global English, the adjustment of China's English language policy, the growth of the education of English majors and the challenges faced by this sector of education. To adapt to…

  11. Future English Teachers' Attitudes towards EIL Pronunciation

    Science.gov (United States)

    Coskun, Abdullah

    2011-01-01

    English has become the world's international language, used for international communication mostly among non-native speakers of other languages and 80 percent of all the English teachers around the world are nonnative English-speaking (NNES) teachers (Canagarajah, 1999). Therefore, there is a growing need to investigate the EIL (English as an…

  12. English Teaching Profile: Sabah--Malaysia.

    Science.gov (United States)

    British Council, London (England). English Language and Literature Div.

    This review of the status of English language instruction in Sabah, Malaysia, provides an overview of the role of English in the society in general and outlines the status of English use and instruction in both the Chinese and government educational systems at all levels. Topics covered are: the characteristics and training of English language…

  13. English Activation through Art: Tensions and Rewards

    Science.gov (United States)

    Choi, Tat Heung

    2017-01-01

    This article describes a unit of work framed by a rationale for activating English language learning through arts-based practices that are suitable for preservice teachers who are nonnative speakers of English (seeking certification for teaching English as a second language). Because teachers of English are expected to use language arts to promote…

  14. English Around the World, Number 6.

    Science.gov (United States)

    McCulloch, John I. B., Ed.

    This newsletter discusses the teaching and role of English around the world. Articles also cover English-language media in a given country, and the opportunity and need for understanding and speaking English in that country. This particular issue contains items on English-language education and use in Belgium, Poland, Afghanistan, Hungary,…

  15. On the Practice Teaching of English Reading

    Science.gov (United States)

    Gao, Yonghong

    2009-01-01

    The main task of practice teaching of English Reading is to train students' independent reading ability and good reading habits. Extra-curricular reading of English literature and English newspapers and magazines plays an active role in improving English reading ability. The principle of selecting reading materials, the scope of selection and the…

  16. Hindsight of an English Language Learner.

    Science.gov (United States)

    Dam, Phap

    This keynote address by a native Vietnamese speaker who did not learn English until he was college-age, through the now obsolete "grammar-translation" method, recounts his difficulties in learning to converse orally in English. He stresses the need to teach conversational English to English Language Learners (ELLs) in addition to…

  17. The Mental Lexicon and English Vocabulary Teaching

    Science.gov (United States)

    He, Huaqing; Deng, Yunfei

    2015-01-01

    In China, English as a foreign language (EFL) learning mainly occurs in the classroom, and the resultant lack of practice using English in authentic settings makes it quite difficult for many Chinese learners to learn English words. They may often feel that English words are "difficult to learn and easy to forget." As such, how to…

  18. English Around the World, Number 2.

    Science.gov (United States)

    McCulloch, John I. B., Ed.

    This newsletter discusses the teaching and role of English around the world. Articles also cover English-language media in a given country, and the opportunity and need for understanding and speaking English in that country. This particular issue contains items on English-language education and use in Malaysia, Singapore, Israel, Jordan, Tunisia,…

  19. Negotiated Syllabus in EAP Business English Courses.

    Science.gov (United States)

    Boyle, Erlinda R.

    Negotiation of syllabus design and content in college-level business English is discussed, looking at three types: negotiation between teachers of business English, between teachers and students of business English, and between business English and content-area business teachers. Examples of practice from the Chinese University of Hong Kong are…

  20. English Around the World, Number 3.

    Science.gov (United States)

    McCulloch, John I. B., Ed.

    This newsletter discusses the teaching and role of English around the world. Articles also cover English-language media in a given country, and the opportunity and need for understanding and speaking English in that country. This particular issue contains items on English education and use in Yugoslavia, Norway, Iceland, Finland, Kenya, Pakistan,…