33 CFR 133.3 - Definitions.

Science.gov (United States)

2010-07-01

... Contingency Plan”, “navigable waters”, “oil”, “remove”, “removal”, “removal costs”, “responsible party... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Definitions. 133.3 Section 133.3... FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL LIABILITY TRUST FUND; STATE ACCESS § 133.3 Definitions...

22 CFR 133.640 - Employee.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Employee. 133.640 Section 133.640 Foreign... ASSISTANCE) Definitions § 133.640 Employee. (a) Employee means the employee of a recipient directly engaged in the performance of work under the award, including— (1) All direct charge employees; (2) All...

Clinical comparison of overlapping deletions of 19p13.3.

Science.gov (United States)

Risheg, Hiba; Pasion, Romela; Sacharow, Stephanie; Proud, Virginia; Immken, LaDonna; Schwartz, Stuart; Tepperberg, Jim H; Papenhausen, Peter; Tan, Tiong Y; Andrieux, Joris; Plessis, Ghislaine; Amor, David J; Keitges, Elisabeth A

2013-05-01

We present three patients with overlapping interstitial deletions of 19p13.3 identified by high resolution SNP microarray analysis. All three had a similar phenotype characterized by intellectual disability or developmental delay, structural heart abnormalities, large head relative to height and weight or macrocephaly, and minor facial anomalies. Deletion sizes ranged from 792 Kb to 1.0 Mb and included a common region arr [hg19] 19p13.3 (3,814,392-4,136,989), containing eight genes: ZFR2, ATCAY, NMRK2, DAPK3, EEF2, PIAS4, ZBTB7A, MAP2K2, and two non-coding RNA's MIR637 and SNORDU37. The patient phenotypes were compared with three previous single patient reports with similar interstitial 19p13.3 deletions and six additional patients from the DECIPHER and ISCA databases to determine if a common haploinsufficient phenotype for the region can be established. Copyright © 2013 Wiley Periodicals, Inc.

21 CFR 133.186 - Sap sago cheese.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Sap sago cheese. 133.186 Section 133.186 Food and... Products § 133.186 Sap sago cheese. (a) Description. (1) Sap sago cheese is the food prepared by the... method described in § 133.5. Sap sago cheese is not less than 5 months old. (2) One or more of the dairy...

Fragrance material review on 1-(3,3-dimethylbicyclo[2.2.1]hept-2-yl)ethane-1-one.

Science.gov (United States)

Scognamiglio, J; Letizia, C S; Api, A M

2013-12-01

A toxicologic and dermatologic review of 1-(3,3-dimethylbicyclo[2.2.1]hept-2-yl)ethane-1-one when used as a fragrance ingredient is presented. 1-(3,3-Dimethylbicyclo[2.2.1]hept-2-yl)ethane-1-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1-(3,3-dimethylbicyclo[2.2.1]hept-2-yl)ethane-1-one were evaluated then summarized and includes physical properties, skin irritation, mucous membrane (eye) irritation, and skin sensitization data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A Toxicologic and Dermatologic Assessment of Alkyl Cyclic Ketones When Used as Fragrance Ingredients (submitted for publication) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances. Copyright © 2013 Elsevier Ltd. All rights reserved.

9 CFR 2.133 - Certification for random source dogs and cats.

Science.gov (United States)

2010-01-01

..., DEPARTMENT OF AGRICULTURE ANIMAL WELFARE REGULATIONS Miscellaneous § 2.133 Certification for random source... of birth or, if unknown, then the approximate age; (iv) The color and any distinctive markings; and...

The Tunka-133 EAS Cherenkov light array: Status of 2011

International Nuclear Information System (INIS)

Berezhnev, S.F.; Besson, D.; Budnev, N.M.; Chiavassa, A.; Chvalaev, O.A.; Gress, O.A.; Dyachok, A.N.; Epimakhov, S.N.; Haungs, A.; Karpov, N.I.; Kalmykov, N.N.; Konstantinov, E.N.; Korobchenko, A.V.; Korosteleva, E.E.; Kozhin, V.A.; Kuzmichev, L.A.; Lubsandorzhiev, B.K.; Lubsandorzhiev, N.B.; Mirgazov, R.R.; Panasyuk, M.I.

2012-01-01

A new EAS Cherenkov light array, Tunka-133, with ∼1km 2 geometrical area has been installed at the Tunka Valley (50 km from Lake Baikal) in 2009. The array permits a detailed study of cosmic ray energy spectrum and mass composition in the energy range 10 16 –10 18 eV with a uniform method. We describe the array construction, DAQ and methods of the array calibration. The method of energy reconstruction and absolute calibration of measurements are discussed. The analysis of spatial and time structure of EAS Cherenkov light allows to estimate the depth of the EAS maximum X max . The results on the all particles energy spectrum and the mean depth of the EAS maximum X max vs. primary energy derived from the data of two winter seasons (2009–2011) are presented. Preliminary results of joint operation of the Cherenkov array with antennas for the detection of EAS radio signals are shown. Plans for future upgrades – deployment of remote clusters, radioantennas and a scintillator detector network and a prototype of the HiSCORE gamma-telescope – are discussed.

The cancer stem cell marker CD133 interacts with plakoglobin and controls desmoglein-2 protein levels.

Directory of Open Access Journals (Sweden)

Ryo Koyama-Nasu

Full Text Available The pentaspan membrane glycoprotein CD133 (also known as prominin-1 has been widely used as a marker for both cancer and normal stem cells. However, the function of CD133 has not been elucidated. Here we describe a cancer stem cell line established from clear cell carcinoma of the ovary (CCC and show that CD133 interacts with plakoglobin (also known as γ-catenin, a desmosomal linker protein. We further demonstrate that knockdown of CD133 by RNA interference (RNAi results in the downregulation of desmoglein-2, a desmosomal cadherin, and abrogates cell-cell adhesion and tumorigenicity of CCC stem cells. We speculate that CD133 may be a promising target for cancer chemotherapy.

Contrast enhancement of bone imaging: use of a asymmetrical energy window of Tc99m MDP (133-145 keV)

International Nuclear Information System (INIS)

Elsaid, M.; Hommoud, S.; Shehab, F.; Elgazzar, A

2004-01-01

Objective: One of the major problems than can affect image quality of bone scan is poor target to non target ratio, due to scattered photons. The ideal Tc-99m energy spectrum is line shaped while the actual one is broader to include attenuated and scattered photons from the soft tissue. The air of this study is to evaluate the effect of asymmetrical 15% energy window of Tc-99m MDP setting at (133-154 keg) on the contrast of bone imaging in comparison to the commonly used 20% symmetrical energy window (126-154 keV). Methods: Sixty adult patients from those who are regularly referred to the clinic for bone scan were scanned twice, after intravenous injection of 925 Mbq (25mCi) of Tc-99m MDP, using 15% (133-154 keV) and 20% (126-154 keV) energy window respectively. Whole body scan was performed on 20 patients, 17 females and 3 males, with ages between 32-61 years. SPECT of the femurs were done on another 20 patients, 2 males and 18 females, with ages between 29-62 years. Planar images were acquired on 20 different patients 6 males and 14 females, with ages between 23-66 years. All technical parameters were kept the same for every group of patients. The acquisition time was recorded in case of the planar views and the count per projection was recorded for each SPECT study. Results: Our preliminary results shows that target to none target ratio were improved in all patients, using the 15% asymmetrical window, compared to the ratio obtained from imaging using the 200/o symmetrical window. The ratios wee increased by 12.4% in the planar images, 9.46% in SPECT images and 11.1% n the whole body images. The improvements in the planner images were on the expense of the acquisition time which increased by 31.1%. Conclusion: We conclude that the use of asymmetrical energy window of 15% (133-154 keV) will improve the image quality of bone scan by enhancing the contrast between bone and soft tissue. (authors)

Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma

Directory of Open Access Journals (Sweden)

Wuwei Li

2014-01-01

Full Text Available Adenoid cystic carcinoma (ACC is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. The primary goal of this study is to investigate the expression patterns of ABCG2, CD133, and podoplanin in ACC of minor salivary glands by immunohistochemistry analysis. We found that ABCG2 was weakly expressed in normal looking salivary gland tissues. A significant upregulation of ABCG2 expression in ACC was observed with a similar expression pattern of Ki-67. CD133 was detected in apical membrane of epithelial cells and podoplanin was expressed positively in myoepithelial cells of both normal looking tissue and ACC. However, no significant difference was found of the expression pattern of CD133 and podoplanin between normal looking tissues and ACC. Our observations suggest that CSCs may exist in quiescent cells with ABCG2 positive staining, which are surrounded by cells with positive expression of ABCG2 and Ki-67 in ACC, and costaining with ABCG2 and Ki-67 may help predict the location of CSCs.

COREL, Ion Implantation in Solids, Range, Straggling Using Thomas-Fermi Cross-Sections. RASE4, Ion Implantation in Solids, Range, Straggling, Energy Deposition, Recoils. DAMG2, Ion Implantation in Solids, Energy Deposition Distribution with Recoils

International Nuclear Information System (INIS)

Brice, D. K.

1979-01-01

1 - Description of problem or function: COREL calculates the final average projected range, standard deviation in projected range, standard deviation in locations transverse to projected range, and average range along path for energetic atomic projectiles incident on amorphous targets or crystalline targets oriented such that the projectiles are not incident along low index crystallographic axes or planes. RASE4 calculates the instantaneous average projected range, standard deviation in projected range, standard deviation in locations transverse to projected range, and average range along path for energetic atomic projectiles incident on amorphous targets or crystalline targets oriented such that the projectiles are not incident along low index crystallographic axes or planes. RASE4 also calculates the instantaneous rate at which the projectile is depositing energy into atomic processes (damage) and into electronic processes (electronic excitation), the average range of target atom recoils projected onto the direction of motion of the projectiles, and the standard deviation in the recoil projected range. DAMG2 calculates the distribution in depth of the energy deposited into atomic processes (damage), electronic processes (electronic excitation), or other energy-dependent quality produced by energetic atomic projectiles incident on amorphous targets or crystalline targets oriented such that the projectiles are not incident along low index crystallographic axes or planes. 2 - Method of solution: COREL: The truncated differential equation which governs the several variables being sought is solved through second-order by trapezoidal integration. The energy-dependent coefficients in the equation are obtained by rectangular integration over the Thomas-Fermi elastic scattering cross section. RASE4: The truncated differential equation which governs the range and straggling variables is solved through second-order by trapezoidal integration. The energy

CD133 expression is not restricted to stem cells, and both CD133+ and CD133– metastatic colon cancer cells initiate tumors

Science.gov (United States)

Shmelkov, Sergey V.; Butler, Jason M.; Hooper, Andrea T.; Hormigo, Adilia; Kushner, Jared; Milde, Till; St. Clair, Ryan; Baljevic, Muhamed; White, Ian; Jin, David K.; Chadburn, Amy; Murphy, Andrew J.; Valenzuela, David M.; Gale, Nicholas W.; Thurston, Gavin; Yancopoulos, George D.; D’Angelica, Michael; Kemeny, Nancy; Lyden, David; Rafii, Shahin

2008-01-01

Colon cancer stem cells are believed to originate from a rare population of putative CD133+ intestinal stem cells. Recent publications suggest that a small subset of colon cancer cells expresses CD133, and that only these CD133+ cancer cells are capable of tumor initiation. However, the precise contribution of CD133+ tumor-initiating cells in mediating colon cancer metastasis remains unknown. Therefore, to temporally and spatially track the expression of CD133 in adult mice and during tumorigenesis, we generated a knockin lacZ reporter mouse (CD133lacZ/+), in which the expression of lacZ is driven by the endogenous CD133 promoters. Using this model and immunostaining, we discovered that CD133 expression in colon is not restricted to stem cells; on the contrary, CD133 is ubiquitously expressed on differentiated colonic epithelium in both adult mice and humans. Using Il10–/–CD133lacZ mice, in which chronic inflammation in colon leads to adenocarcinomas, we demonstrated that CD133 is expressed on a full gamut of colonic tumor cells, which express epithelial cell adhesion molecule (EpCAM). Similarly, CD133 is widely expressed by human primary colon cancer epithelial cells, whereas the CD133– population is composed mostly of stromal and inflammatory cells. Conversely, CD133 expression does not identify the entire population of epithelial and tumor-initiating cells in human metastatic colon cancer. Indeed, both CD133+ and CD133– metastatic tumor subpopulations formed colonospheres in in vitro cultures and were capable of long-term tumorigenesis in a NOD/SCID serial xenotransplantation model. Moreover, metastatic CD133– cells form more aggressive tumors and express typical phenotypic markers of cancer-initiating cells, including CD44 (CD44+CD24–), whereas the CD133+ fraction is composed of CD44lowCD24+ cells. Collectively, our data suggest that CD133 expression is not restricted to intestinal stem or cancer-initiating cells, and during the metastatic

Energy dependence of polymer gels in the orthovoltage energy range

Directory of Open Access Journals (Sweden)

Yvonne Roed

2014-03-01

Full Text Available Purpose: Ortho-voltage energies are often used for treatment of patients’ superficial lesions, and also for small- animal irradiations. Polymer-Gel dosimeters such as MAGAT (Methacrylic acid Gel and THPC are finding increasing use for 3-dimensional verification of radiation doses in a given treatment geometry. For mega-voltage beams, energy dependence of MAGAT has been quoted as nearly energy-independent. In the kilo-voltage range, there is hardly any literature to shade light on its energy dependence.Methods: MAGAT was used to measure depth-dose for 250 kVp beam. Comparison with ion-chamber data showed a discrepancy increasing significantly with depth. An over-response as much as 25% was observed at a depth of 6 cm.Results and Conclusion: Investigation concluded that 6 cm water in the beam resulted in a half-value-layer (HVL change from 1.05 to 1.32 mm Cu. This amounts to an effective-energy change from 81.3 to 89.5 keV. Response measurements of MAGAT at these two energies explained the observed discrepancy in depth-dose measurements. Dose-calibration curves of MAGAT for (i 250 kVp beam, and (ii 250 kVp beam through 6 cm of water column are presented showing significant energy dependence.-------------------Cite this article as: Roed Y, Tailor R, Pinksy L, Ibbott G. Energy dependence of polymer gels in the orthovoltage energy range. Int J Cancer Ther Oncol 2014; 2(2:020232. DOI: 10.14319/ijcto.0202.32 

Total photoabsorption cross section on nuclei measured in energy range 0.5-2.6 GeV

International Nuclear Information System (INIS)

Mirazita, M.

1998-03-01

The total photoabsorption cross section on several nuclei has been measured in the energy range 0.5 - 2.6 GeV. Nuclear data show a significant reduction of the absorption strength with respect to the free nucleon case suggesting a shadowing effect at low energies

Structural, Dynamical, and Energetical Consequences of Rett Syndrome Mutation R133C in MeCP2

Directory of Open Access Journals (Sweden)

Tugba G. Kucukkal

2015-01-01

Full Text Available Rett Syndrome (RTT is a progressive neurodevelopmental disease affecting females. RTT is caused by mutations in the MECP2 gene and various amino acid substitutions have been identified clinically in different domains of the multifunctional MeCP2 protein encoded by this gene. The R133C variant in the methylated-CpG-binding domain (MBD of MeCP2 is the second most common disease-causing mutation in the MBD. Comparative molecular dynamics simulations of R133C mutant and wild-type MBD have been performed to understand the impact of the mutation on structure, dynamics, and interactions of the protein and subsequently understand the disease mechanism. Two salt bridges within the protein and two critical hydrogen bonds between the protein and DNA are lost upon the R133C mutation. The mutation was found to weaken the interaction with DNA and also cause loss of helicity within the 141-144 region. The structural, dynamical, and energetical consequences of R133C mutation were investigated in detail at the atomic resolution. Several important implications of this have been shown regarding protein stability and hydration dynamics as well as its interaction with DNA. The results are in agreement with previous experimental studies and further provide atomic level understanding of the molecular origin of RTT associated with R133C variant.

Rare gas isotope yields in bremsstrahlung-induced nuclear reactions of 41K, 87Rb, 127I, 133Cs, and 139La

International Nuclear Information System (INIS)

Oura, Y.; Yazawa, A.; Sarkar, S.R.; Sakamoto, K.; Shibata, S.; Fujiwara, I.; Furukawa, M.

1994-05-01

Radiochemical yield measurements have been reported for 41 K(γ, π + ) 41 Ar, 87 Rb(γ, π + ) 87 Kr, 133 Cs(γ, π + ) 133m,133g Xe, 127 I(γ, π - xn) 127-x Xe (x=0,2,4,5, and 6), 133 Cs(γ, pxn) 132-x Xe (x=1,3,5,7,9,10, and 11), and 139 La(γ, 3pxn) 136- xXe (x=7,9,11,13,14, and 15) at bremsstrahlung end-point energies(E 0 ) of 50-1200 MeV. For photopion reactions it has been confirmed that the both yields of (γ, π - ) and (γ, π + ) reactions are independent of target mass (A t ) and the yield ratios of (γ, π - ) to (γ, π + ) reactions are about 5 over the studied ranges of E 0 and A t . The profile of 127 I(γ, π - xn) yields as a function of x is similar to that of 133 Cs but quite different from that of 51 V when compared at the same E 0 , suggesting a strong A t dependence. It is also found that the photospallogenic Xe isotope yields from 133 Cs and 139 La are consistent with the reported mass yield pattems of the other radionuclides produced from the same targets. These results are discussed by referring to the previous literature values and to a cascade-evaporation calculation based on the PICA code by Gabriel and Alsmiller. (author)

Transformation of Au144(SCH2CH2Ph)60 to Au133(SPh-tBu)52 Nanomolecules: Theoretical and Experimental Study.

Science.gov (United States)

Nimmala, Praneeth Reddy; Theivendran, Shevanuja; Barcaro, Giovanni; Sementa, Luca; Kumara, Chanaka; Jupally, Vijay Reddy; Apra, Edoardo; Stener, Mauro; Fortunelli, Alessandro; Dass, Amala

2015-06-04

Ultrastable gold nanomolecule Au144(SCH2CH2Ph)60 upon etching with excess tert-butylbenzenethiol undergoes a core-size conversion and compositional change to form an entirely new core of Au133(SPh-tBu)52. This conversion was studied using high-resolution electrospray mass spectrometry which shows that the core size conversion is initiated after 22 ligand exchanges, suggesting a relatively high stability of the Au144(SCH2CH2Ph)38(SPh-tBu)22 intermediate. The Au144 → Au133 core size conversion is surprisingly different from the Au144 → Au99 core conversion reported in the case of thiophenol, -SPh. Theoretical analysis and ab initio molecular dynamics simulations show that rigid p-tBu groups play a crucial role by reducing the cluster structural freedom, and protecting the cluster from adsorption of exogenous and reactive species, thus rationalizing the kinetic factors that stabilize the Au133 core size. This 144-atom to 133-atom nanomolecule's compositional change is reflected in optical spectroscopy and electrochemistry.

Energy-range relation and mean energy variation in therapeutic particle beams

International Nuclear Information System (INIS)

Kempe, Johanna; Brahme, Anders

2008-01-01

Analytical expressions for the mean energy and range of therapeutic light ion beams and low- and high-energy electrons have been derived, based on the energy dependence of their respective stopping powers. The new mean energy and range relations are power-law expressions relevant for light ion radiation therapy, and are based on measured practical ranges or known tabulated stopping powers and ranges for the relevant incident particle energies. A practical extrapolated range, R p , for light ions was defined, similar to that of electrons, which is very closely related to the extrapolated range of the primary ions. A universal energy-range relation for light ions and electrons that is valid for all material mixtures and compounds has been developed. The new relation can be expressed in terms of the range for protons and alpha particles, and is found to agree closely with experimental data in low atomic number media and when the difference in the mean ionization energy is low. The variation of the mean energy with depth and the new energy-range relation are useful for accurate stopping power and mass scattering power calculations, as well as for general particle transport and dosimetry applications

Differential number of CD34+, CD133+ and CD34+/CD133+ cells in peripheral blood of patients with congestive heart failure

Directory of Open Access Journals (Sweden)

Fritzenwanger M

2009-03-01

Full Text Available Abstract Background Endothelial progenitor cells (EPC which are characterised by the simulateous expression of CD34, CD133 and vascular endothelial growth receptor 2 (VEGF 2 are involved in the pathophysiology of congestive heart failure (CHF and their number and function is reduced in CHF. But so far our knowledge about the number of circulating hematopoietic stem/progenitor cells (CPC expressing the early hematopoietic marker CD133 and CD34 in CHF is spares and therefore we determined their number and correlated them with New York Heart Association (NYHA functional class. Methods CD34 and CD133 surface expression was quantified by flow cytometry in the peripheral venous blood of 41 healthy adults and 101 patients with various degrees of CHF. Results CD34+, CD133+ and CD34+/CD133+ cells correlated inversely with age. Both the number of CD34+ and of CD34+/CD133+ cells inversely correlated with NYHA functional class. The number of CD133+ cells was not affected by NYHA class. Furthermore the number of CD133+ cells did not differ between control and CHF patients. Conclusion In CHF the release of CD34+, CD133+ and CD34+/CD133+ cells from the bone marrow seems to be regulated differently. Modulating the releasing process in CHF may be a tool in CHF treatment.

A comparison of the cosmic-ray energy scales of Tunka-133 and KASCADE-Grande via their radio extensions Tunka-Rex and LOPES

Directory of Open Access Journals (Sweden)

W.D. Apel

2016-12-01

Full Text Available The radio technique is a promising method for detection of cosmic-ray air showers of energies around 100PeV and higher with an array of radio antennas. Since the amplitude of the radio signal can be measured absolutely and increases with the shower energy, radio measurements can be used to determine the air-shower energy on an absolute scale. We show that calibrated measurements of radio detectors operated in coincidence with host experiments measuring air showers based on other techniques can be used for comparing the energy scales of these host experiments. Using two approaches, first via direct amplitude measurements, and second via comparison of measurements with air shower simulations, we compare the energy scales of the air-shower experiments Tunka-133 and KASCADE-Grande, using their radio extensions, Tunka-Rex and LOPES, respectively. Due to the consistent amplitude calibration for Tunka-Rex and LOPES achieved by using the same reference source, this comparison reaches an accuracy of approximately 10% – limited by some shortcomings of LOPES, which was a prototype experiment for the digital radio technique for air showers. In particular we show that the energy scales of cosmic-ray measurements by the independently calibrated experiments KASCADE-Grande and Tunka-133 are consistent with each other on this level.

10 CFR 26.133 - Cutoff levels for drugs and drug metabolites.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Cutoff levels for drugs and drug metabolites. 26.133... § 26.133 Cutoff levels for drugs and drug metabolites. Subject to the provisions of § 26.31(d)(3)(iii), licensees and other entities may specify more stringent cutoff levels for drugs and drug metabolites than...

Solvothermal synthesis of a new 3-D mixed-metal sulfide framework, (H{sub 1.33}tren)[In{sub 2.67}Sb{sub 1.33}S{sub 8}]·tren

Energy Technology Data Exchange (ETDEWEB)

Lampkin, John D., E-mail: j.lampkin@pgr.rdg.ac.uk; Powell, Anthony V., E-mail: a.v.powell@rdg.ac.uk; Chippindale, Ann M., E-mail: a.m.chippindale@rdg.ac.uk

2016-11-15

A new indium(III) antimony(V) sulfide, (H{sub 1.33}tren)[In{sub 2.67}Sb{sub 1.33}S{sub 8}]·tren, has been prepared solvothermally at 433 K. The compound crystallises in the tetragonal space group I-42d (lattice parameters, a=12.6248(5) and c=19.4387(18) Å at 150 K) and contains adamantane-like T2 supertetrahedral units comprised of corner-sharing InS{sub 4}{sup 5−} and SbS{sub 4}{sup 3−} tetrahedra. The adamantane-like units are then linked through sulfur vertices to generate an open, 3-D framework structure containing large pores in which neutral, protonated tren (tris(2-aminoethylene)amine) molecules reside. The presence of the organic components was confirmed by solid-state {sup 13}C NMR (10 kHz), combustion and thermogravimetric analysis. The band gap, obtained from UV–vis diffuse reflectance measurements, is 2.7(2) eV. Stirring with either water or alkali-metal salt solution leads to removal of the neutral tren molecules and an ~9% reduction in unit-cell volume on formation of (H{sub 1.33}tren)[In{sub 2.67}Sb{sub 1.33}S{sub 8}]·(H{sub 2}O){sub 4}. - Graphical abstract: Linking of In(III)-Sb(V)-S adamantane units to form a 3-D open framework. - Highlights: • Preparation and structural characterisation of a new mixed-metal thiometallate. • The first mixed In(III)/Sb(V) supertetrahedron. • Optical band gap of 2.7(2) eV. • Soaking in aqueous alkali-metal solutions leads to removal of ca. 50% of the organic content.

Band head spin assignment of superdeformed bands in 133Pr using two-parameter formulae

Science.gov (United States)

Sharma, Honey; Mittal, H. M.

2018-03-01

The two-parameter formulae viz. the power index formula, the nuclear softness formula and the VMI model are adopted to accredit the band head spin (I0) of four superdeformed rotational bands in 133Pr. The technique of least square fitting is used to accredit the band head spin for four superdeformed rotational bands in 133Pr. The root mean deviation among the computed transition energies and well-known experimental transition energies are attained by extracting the model parameters from the two-parameter formulae. The determined transition energies are in excellent agreement with the experimental transition energies, whenever exact spins are accredited. The power index formula coincides well with the experimental data and provides minimum root mean deviation. So, the power index formula is more efficient tool than the nuclear softness formula and the VMI model. The deviation of dynamic moment of inertia J(2) against the rotational frequency is also examined.

Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor.

Directory of Open Access Journals (Sweden)

Shih-Hwa Chiou

2008-05-01

Full Text Available Atypical teratoid/rhabdoid tumor (AT/RT is an extremely malignant neoplasm in the central nervous system (CNS which occurs in infancy and childhood. Recent studies suggested that CD133 could be considered a marker for brain cancer stem-like cells (CSCs. However, the role of CD133 in AT/RT has never been investigated. Herein we report the isolation of CD133-positive cells (CD133(+, found to have the potential to differentiate into three germ layer tissues, from tissues of nine AT/RT patients. The migration/invasion/malignancy and radioresistant capabilities of CD133(+ were significantly augmented when compared to CD133(-. The clinical data showed that the amount of CD133(+ in AT/RTs correlated positively with the degree of resistance to radiation therapy. Using cDNA microarray analysis, the genotoxic-response profiles of CD133(+ and CD133(- irradiated with 10 Gy ionizing radiation (IR were analyzed 0.5, 2, 6, 12 and 24 h post-IR. We then validated these microarray data and showed increased phosphorylation after IR of p-ATM, p-RAD17, and p-CHX2 as well as increased expression of BCL-2 protein in CD133(+ compared to CD133(-. Furthermore, we found that CD133(+ can effectively resist IR with cisplatin- and/or TRAIL-induced apoptosis. Immunohistochemical analysis confirmed the up-regulated expression of p-ATM and BCL-2 proteins in IR-treated CD133(+ xenotransgrafts in SCID mice but not in IR-treated CD133(-. Importantly, the effect of IR in CD133(+ transplanted mice can be significantly improved by a combination of BCL-2 siRNA with debromohymenialdisine, an inhibitor of checkpoint kinases. In sum, this is the first report indicating that CD133(+ AT/RT cells demonstrate the characteristics of CSCs. The IR-resistant and anti-apoptotic properties in CD133(+ may reflect the clinical refractory malignancy of AT/RTs and thus the activated p-ATM pathway and BCL-2 expression in CD133(+ could be possible targets to improve future treatment of deadly diseases

46 CFR 133.140 - Stowage of rescue boats.

Science.gov (United States)

2010-10-01

... SYSTEMS Requirements for All OSVs § 133.140 Stowage of rescue boats. (a) Rescue boats must be stowed as follows: (1) Each rescue boat must be ready for launching in not more than 5 minutes. (2) Each rescue boat... 46 Shipping 4 2010-10-01 2010-10-01 false Stowage of rescue boats. 133.140 Section 133.140...

49 CFR 176.133 - Magazine stowage Type C.

Science.gov (United States)

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Magazine stowage Type C. 176.133 Section 176.133... Requirements for Class 1 (Explosive) Materials Stowage § 176.133 Magazine stowage Type C. The construction requirements for magazine stowage type C are the same as for a closed cargo transport unit in § 176.63(e). In...

21 CFR 133.124 - Cold-pack cheese food.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Cold-pack cheese food. 133.124 Section 133.124 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD... Cheese and Related Products § 133.124 Cold-pack cheese food. (a)(1) Cold-pack cheese food is the food...

Dual-targeting immunoliposomes using angiopep-2 and CD133 antibody for glioblastoma stem cells.

Science.gov (United States)

Kim, Jung Seok; Shin, Dae Hwan; Kim, Jin-Seok

2018-01-10

Glioblastoma stem cells (GSCs), which are identified as subpopulation of CD133 + /ALDH1 + , are known to show resistance to the most of chemotherapy and radiation therapy, leading to the recurrence of tumor in glioblastoma multiforme (GBM) patients. Also, delivery of temozolomide (TMZ), a mainline treatment of GBM, to the GBM site is hampered by various barriers including the blood-brain barrier (BBB). A dual-targeting immunoliposome encapsulating TMZ (Dual-LP-TMZ) was developed by using angiopep-2 (An2) and anti-CD133 monoclonal antibody (CD133 mAb) for BBB transcytosis and specific delivery to GSCs, respectively. The size, zeta potential and drug encapsulation efficiency of Dual-LP-TMZ were 203.4nm in diameter, -1.6mV and 99.2%, respectively. The in vitro cytotoxicity of Dual-LP-TMZ against U87MG GSCs was increased by 425- and 181-folds when compared with that of free TMZ and non-targeted TMZ liposome (LP-TMZ) (10.3μM vs. 4380μM and 1869μM in IC 50 , respectively). Apoptosis and anti-migration ability of Dual-LP-TMZ in U87MG GSCs were also significantly enhanced comparing with those of free TMZ or LP-TMZ. In vivo study clearly showed a significant reduction in tumor size after intravenous administrations of Dual-LP-TMZ to the orthotopically-implanted brain tumor mice when compared with free TMZ or LP-TMZ. Increased life span (ILS) and median survival time (MST) of tumor-bearing mice were also increased when treated with Dual-LP-TMZ (211.2% in ILS and 49.2days in MST) than with free TMZ (0% in ILS and 23.3day in MST). These data indicate that conjugation of both An2 peptide and CD133 mAb to TMZ-encapsulating liposome is very effective in delivering the TMZ to GSCs via BBB, suggesting a potential use of Dual-LP-TMZ as a therapeutic modality for GBM. Copyright © 2017 Elsevier B.V. All rights reserved.

Full GMP-Compliant Validation of Bone Marrow-Derived Human CD133+ Cells as Advanced Therapy Medicinal Product for Refractory Ischemic Cardiomyopathy

Directory of Open Access Journals (Sweden)

Daniela Belotti

2015-01-01

Full Text Available According to the European Medicine Agency (EMA regulatory frameworks, Advanced Therapy Medicinal Products (ATMP represent a new category of drugs in which the active ingredient consists of cells, genes, or tissues. ATMP-CD133 has been widely investigated in controlled clinical trials for cardiovascular diseases, making CD133+ cells one of the most well characterized cell-derived drugs in this field. To ensure high quality and safety standards for clinical use, the manufacturing process must be accomplished in certified facilities following standard operative procedures (SOPs. In the present work, we report the fully compliant GMP-grade production of ATMP-CD133 which aims to address the treatment of chronic refractory ischemic heart failure. Starting from bone marrow (BM, ATMP-CD133 manufacturing output yielded a median of 6.66 × 106 of CD133+ cells (range 2.85 × 106–30.84 × 106, with a viability ranged between 96,03% and 99,97% (median 99,87% and a median purity of CD133+ cells of 90,60% (range 81,40%–96,20%. Based on these results we defined our final release criteria for ATMP-CD133: purity ≥ 70%, viability ≥ 80%, cellularity between 1 and 12 × 106 cells, sterile, and endotoxin-free. The abovementioned criteria are currently applied in our Phase I clinical trial (RECARDIO Trial.

Full GMP-compliant validation of bone marrow-derived human CD133(+) cells as advanced therapy medicinal product for refractory ischemic cardiomyopathy.

Science.gov (United States)

Belotti, Daniela; Gaipa, Giuseppe; Bassetti, Beatrice; Cabiati, Benedetta; Spaltro, Gabriella; Biagi, Ettore; Parma, Matteo; Biondi, Andrea; Cavallotti, Laura; Gambini, Elisa; Pompilio, Giulio

2015-01-01

According to the European Medicine Agency (EMA) regulatory frameworks, Advanced Therapy Medicinal Products (ATMP) represent a new category of drugs in which the active ingredient consists of cells, genes, or tissues. ATMP-CD133 has been widely investigated in controlled clinical trials for cardiovascular diseases, making CD133(+) cells one of the most well characterized cell-derived drugs in this field. To ensure high quality and safety standards for clinical use, the manufacturing process must be accomplished in certified facilities following standard operative procedures (SOPs). In the present work, we report the fully compliant GMP-grade production of ATMP-CD133 which aims to address the treatment of chronic refractory ischemic heart failure. Starting from bone marrow (BM), ATMP-CD133 manufacturing output yielded a median of 6.66 × 10(6) of CD133(+) cells (range 2.85 × 10(6)-30.84 × 10(6)), with a viability ranged between 96,03% and 99,97% (median 99,87%) and a median purity of CD133(+) cells of 90,60% (range 81,40%-96,20%). Based on these results we defined our final release criteria for ATMP-CD133: purity ≥ 70%, viability ≥ 80%, cellularity between 1 and 12 × 10(6) cells, sterile, and endotoxin-free. The abovementioned criteria are currently applied in our Phase I clinical trial (RECARDIO Trial).

Full GMP-Compliant Validation of Bone Marrow-Derived Human CD133+ Cells as Advanced Therapy Medicinal Product for Refractory Ischemic Cardiomyopathy

Science.gov (United States)

Belotti, Daniela; Gaipa, Giuseppe; Bassetti, Beatrice; Cabiati, Benedetta; Spaltro, Gabriella; Biagi, Ettore; Parma, Matteo; Biondi, Andrea; Cavallotti, Laura; Gambini, Elisa; Pompilio, Giulio

2015-01-01

According to the European Medicine Agency (EMA) regulatory frameworks, Advanced Therapy Medicinal Products (ATMP) represent a new category of drugs in which the active ingredient consists of cells, genes, or tissues. ATMP-CD133 has been widely investigated in controlled clinical trials for cardiovascular diseases, making CD133+ cells one of the most well characterized cell-derived drugs in this field. To ensure high quality and safety standards for clinical use, the manufacturing process must be accomplished in certified facilities following standard operative procedures (SOPs). In the present work, we report the fully compliant GMP-grade production of ATMP-CD133 which aims to address the treatment of chronic refractory ischemic heart failure. Starting from bone marrow (BM), ATMP-CD133 manufacturing output yielded a median of 6.66 × 106 of CD133+ cells (range 2.85 × 106–30.84 × 106), with a viability ranged between 96,03% and 99,97% (median 99,87%) and a median purity of CD133+ cells of 90,60% (range 81,40%–96,20%). Based on these results we defined our final release criteria for ATMP-CD133: purity ≥ 70%, viability ≥ 80%, cellularity between 1 and 12 × 106 cells, sterile, and endotoxin-free. The abovementioned criteria are currently applied in our Phase I clinical trial (RECARDIO Trial). PMID:26495296

Nitrous Oxide (N2O) Emissions from Waste and Biomass to Energy Plants

Czech Academy of Sciences Publication Activity Database

Fernandez-Gutierrez, M.-J.; Baxter, D.; Hunter, Ch.; Svoboda, Karel

2005-01-01

Roč. 23, č. 2 (2005), s. 133-147 ISSN 0734-242X Institutional research plan: CEZ:AV0Z40720504 Keywords : N2O * waste * incineration Subject RIV: JE - Non-nuclear Energetics, Energy Consumption ; Use Impact factor: 0.396, year: 2005

Measurement of regional cerebral blood flow by intravenous administation of 133 xenon

International Nuclear Information System (INIS)

Ryding, E.

1986-01-01

Reviewing the background and the theory for rCFB measurements the following conditions are established for the use of flow measurement with 133-Xenon as a reliable indicator for indirect measurements of cerebral functional activity. 1. There is a strict coupling between rCBF and regional metabolism. This condition can only be considered to be fulfilled in the normal non-anoxic bran tissue. 2. There is a close correlation between the tissue and the venous concentration of 133-Xenin which can be reliably approximated by the blood-brain partition coefficient. This condition can be considered to be fullfilled in the normal flow range, but not in pathological conditions such as cerebrovascular occlusions. 3. Intercompartment diffusion of 133-Xenon has no significant effect upon the measurement of rCBF values. This condition appear to share its limitations for fulfilement with condition 2. 4. There is no significant contamination by the extracerebral flow components at IH or IV rCBF measurements. 5. There is a negligible 'look through' effect from surrounding areas to region with focal high or low blood flow. (U.W.)

Nitric oxide synthase 2 is required for conversion of pro-fibrogenic inflammatory CD133(+) progenitors into F4/80(+) macrophages in experimental autoimmune myocarditis.

Science.gov (United States)

Blyszczuk, Przemyslaw; Berthonneche, Corrine; Behnke, Silvia; Glönkler, Marcel; Moch, Holger; Pedrazzini, Thierry; Lüscher, Thomas F; Eriksson, Urs; Kania, Gabriela

2013-02-01

Experimental autoimmune myocarditis (EAM) model mirrors important mechanisms of inflammatory dilated cardiomyopathy (iDCM). In EAM, inflammatory CD133(+) progenitors are a major cellular source of cardiac myofibroblasts in the post-inflammatory myocardium. We hypothesized that exogenous delivery of macrophage-colony-stimulating factor (M-CSF) can stimulate macrophage lineage differentiation of inflammatory progenitors and, therefore, prevent their naturally occurring myofibroblast fate in EAM. EAM was induced in wild-type (BALB/c) and nitric oxide synthase 2-deficient (Nos2(-/-)) mice and CD133(+) progenitors were isolated from inflamed hearts. In vitro, M-CSF converted inflammatory CD133(+) progenitors into nitric oxide-producing F4/80(+) macrophages and prevented transforming growth factor-β-mediated myofibroblast differentiation. Importantly, only a subset of heart-infiltrating CD133(+) progenitors expresses macrophage-specific antigen F4/80 in EAM. These CD133(+)/F4/80(hi) cells show impaired myofibrogenic potential compared with CD133(+)/F4/80(-) cells. M-CSF treatment of wild-type mice with EAM at the peak of disease markedly increased CD133(+)/F4/80(hi) cells in the myocardium, and CD133(+) progenitors isolated from M-CSF-treated mice failed to differentiate into myofibroblasts. In contrast, M-CSF was not effective in converting CD133(+) progenitors from inflamed hearts of Nos2(-/-) mice into macrophages, and M-CSF treatment did not result in increased CD133(+)/F4/80(hi) cell population in hearts of Nos2(-/-) mice. Accordingly, M-CSF prevented post-inflammatory fibrosis and left ventricular dysfunction in wild-type but not in Nos2(-/-) mice. Active and NOS2-dependent induction of macrophage lineage differentiation abrogates the myofibrogenic potential of heart-infiltrating CD133(+) progenitors. Modulating the in vivo differentiation fate of specific progenitors might become a novel approach for the treatment of inflammatory heart diseases.

Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy.

Science.gov (United States)

Bostad, Monica; Olsen, Cathrine Elisabeth; Peng, Qian; Berg, Kristian; Høgset, Anders; Selbo, Pål Kristian

2015-05-28

The cancer stem cell (CSC) marker CD133 is an attractive target to improve antitumor therapy. We have used photochemical internalization (PCI) for the endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin (PCIAC133-saporin). PCI employs an endocytic vesicle-localizing photosensitizer, which generates reactive oxygen species upon light-activation causing a rupture of the vesicle membranes and endosomal escape of entrapped drugs. Here we show that AC133-saporin co-localizes with the PCI-photosensitizer TPCS2a, which upon light exposure induces cytosolic release of AC133-saporin. PCI of picomolar levels of AC133-saporin in colorectal adenocarcinoma WiDr cells blocked cell proliferation and induced 100% inhibition of cell viability and colony forming ability at the highest light doses, whereas no cytotoxicity was obtained in the absence of light. Efficient PCI-based CD133-targeting was in addition demonstrated in the stem-cell-like, triple negative breast cancer cell line MDA-MB-231 and in the aggressive malignant melanoma cell line FEMX-1, whereas no enhanced targeting was obtained in the CD133-negative breast cancer cell line MCF-7. PCIAC133-saporin induced mainly necrosis and a minimal apoptotic response based on assessing cleavage of caspase-3 and PARP, and the TUNEL assay. PCIAC133-saporin resulted in S phase arrest and reduced LC3-II conversion compared to control treatments. Notably, co-treatment with Bafilomycin A1 and PCIAC133-saporin blocked LC3-II conversion, indicating a termination of the autophagic flux in WiDr cells. For the first time, we demonstrate laser-controlled targeting of CD133 in vivo. After only one systemic injection of AC133-saporin and TPCS2a, a strong anti-tumor response was observed after PCIAC133-saporin. The present PCI-based endosomal escape technology represents a minimally invasive strategy for spatio-temporal, light-controlled targeting of CD133+ cells in localized primary tumors or metastasis. Copyright © 2015

Dissociative photoionization of IBr following I(4d) and Br(3d) inner-shell excitations in the range of 60 ∼ 133 eV: remarkable biased charge spread relevant to the core-hole states

International Nuclear Information System (INIS)

Boo, Bong Hyun; Koyano, Inosuke

2002-01-01

Dissociative photoionization of an interhalogen molecule, iodine monobromide (IBr), spanning the I(4d) and the Br(3d) inner-shell excitation/ionization regions has been studied by using time-of-flight (TOF) mass spectrometry coupled to synchrotron radiation in the range of 60 ∼ 133 eV. The total and the individual photoion yields have been recorded as functions of the photon energy. Here, a giant shape resonance has been observed owing to the I(4d 10 ) →I(4d 9 εf) transition, the transition probability for which outweighs that for the Br(3d 10 ) →Br(3d 9 εf) excitation. In addition to the huge resonance, discrete resonances owing to the Br(3d) -1 IBr(4pσ + ) and the Br(3d -1 )Br(5p) transitions, with very weak intensities, are observed at 70.5 and 73.6 eV and have spin-orbit splittings of = 1.0 and = 0.9 eV, respectively. The dissociation processes of singly and doubly charged parent ions have also been evaluated from the variations of the individual ion and photoion-photoion coincidence (PIPICO) yields with the photon energy. Below the Br(3d) threshold, including the Br(3d) discrete excitation region, 60 + and I 2+ ions are exclusively formed with a trace number of Br + ions. Slightly above the Br(3d) threshold, more specifically at 77.5 eV, however, photoionization events leading to the formations of Br + and Br 2- prevail. At higher energies beyond the Br(3d) threshold, 78 + and I 2+ turn out to exceed again those for Br + and Br 2+ , respectively. Over the entire energy range examined, a remarkable biased charge spread in dissociative photoionization events is observed, presumably reflecting the fact that charge localized mostly in the excited atoms relevant to the specific inner-shell excitation, which can be accounted for mainly by a two-step decay process via a fast dissociation followed by autoionization upon vuv absorption

Crossed beam study of He+-O2 charge transfer reactions in the collision energy range 0.5-200 eV

International Nuclear Information System (INIS)

Bischof, G.; Linder, F.

1986-01-01

Energy spectra and angular distributions of the O + and O 2 + product ions resulting from the He + -O 2 charge transfer reaction have been measured in the collision energy range 0.5-200 eV using the crossed-beam method. The O 2 + ions represent only a minor fraction of the reaction products (0.2-0.6% over the energy range measured). In the dissociative charge transfer reaction, four main processes are identified leading to O+O + reaction products in different electronic states. Two different mechanisms can be distinguished, each being responsible for two of the observed processes: (i) a long-distance energy-resonant charge transfer process involving the c 4 Σsub(u) - (upsilon'=0) state of O 2 + and (ii) a slightly exothermic charge transfer process via the (III) 2 PIsub(u) state of O 2 + (with the exothermicity depending on the collision energy). Angle-integrated branching ratios and partial cross sections (in absolute units) have been determined. The branching ratios of the individual processes show a pronounced dependence on the collision energy. At low energies, the O + product ions are preferentially formed in the 2 P 0 and 2 D 0 excited states. The angular distributions of the O + product ions show an anisotropic behaviour indicating an orientation-dependent charge transfer probability in the He + -O 2 reaction. (orig.)

Synthesis, crystal structure and Raman spectrum of Ba{sub 7}[BO{sub 3}]{sub 3}Br(O{sub 1.33}F{sub 1.33})

Energy Technology Data Exchange (ETDEWEB)

Reckeweg, Olaf; DiSalvo, Francis J. [Cornell Univ., Ithaca, NY (United States). Dept. of Chemistry and Chemical Biology; Schulz, Armin [Max-Planck-Institut fuer Festkoerperforschung, Stuttgart (Germany)

2017-05-01

In addition to amorphous material and Ba{sub 7}[BO{sub 3}]{sub 4-x}F{sub 2-3x}, air and moisture sensitive single crystals of Ba{sub 7}[BO{sub 3}]{sub 3}Br(O{sub 1.33}F{sub 1.33}) were formed from H{sub 3}BO{sub 3}, Ba(OH){sub 2}, BaF{sub 2} and BaBr{sub 2} . H{sub 2}O in alumina crucibles open to the atmosphere at 1300 K for 13 h. Ba{sub 7}[BO{sub 3}]{sub 3}Br(O{sub 1.33}F{sub 1.33}) crystallizes in the hexagonal space group P6{sub 3}mc (no. 186, Z=2) with the lattice parameters a=1118.1(2) and c=723.93(13) pm. The Raman spectrum of the title compounds was also acquired and is compared to literature data.

22 CFR 133.655 - Individual.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Individual. 133.655 Section 133.655 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 133.655 Individual. Individual means a natural person. ...

An accurate energy-range relationship for high-energy electron beams in arbitrary materials

International Nuclear Information System (INIS)

Sorcini, B.B.; Brahme, A.

1994-01-01

A general analytical energy-range relationship has been derived to relate the practical range, R p to the most probable energy, E p , of incident electron beams in the range 1 to 50 MeV and above, for absorbers of any atomic number. In the present study only Monte Carlo data determined with the new ITS.3 code have been employed. The standard deviations of the mean deviation from the Monte Carlo data at any energy are about 0.10, 0.12, 0.04, 0.11, 0.04, 0.03, 0.02 mm for Be, C, H 2 O, Al, Cu, Ag and U, respectively, and the relative standard deviation of the mean is about 0.5% for all materials. The fitting program gives some priority to water-equivalent materials, which explains the low standard deviation for water. A small error in the fall-off slope can give a different value for R p . We describe a new method which reduces the uncertainty in the R p determination, by fitting an odd function to the descending portion of the depth-dose curve in order to accurately determine the tangent at the inflection point, and thereby the practical range. An approximate inverse relation is given expressing the most probable energy of an electron beam as a function of the practical range. The resultant relative standard error of the energy is less than 0.7%, and the maximum energy error ΔE p is less than 0.3 MeV. (author)

Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders.

Directory of Open Access Journals (Sweden)

Anthony R Isles

2016-05-01

Full Text Available Duplications at 15q11.2-q13.3 overlapping the Prader-Willi/Angelman syndrome (PWS/AS region have been associated with developmental delay (DD, autism spectrum disorder (ASD and schizophrenia (SZ. Due to presence of imprinted genes within the region, the parental origin of these duplications may be key to the pathogenicity. Duplications of maternal origin are associated with disease, whereas the pathogenicity of paternal ones is unclear. To clarify the role of maternal and paternal duplications, we conducted the largest and most detailed study to date of parental origin of 15q11.2-q13.3 interstitial duplications in DD, ASD and SZ cohorts. We show, for the first time, that paternal duplications lead to an increased risk of developing DD/ASD/multiple congenital anomalies (MCA, but do not appear to increase risk for SZ. The importance of the epigenetic status of 15q11.2-q13.3 duplications was further underlined by analysis of a number of families, in which the duplication was paternally derived in the mother, who was unaffected, whereas her offspring, who inherited a maternally derived duplication, suffered from psychotic illness. Interestingly, the most consistent clinical characteristics of SZ patients with 15q11.2-q13.3 duplications were learning or developmental problems, found in 76% of carriers. Despite their lower pathogenicity, paternal duplications are less frequent in the general population with a general population prevalence of 0.0033% compared to 0.0069% for maternal duplications. This may be due to lower fecundity of male carriers and differential survival of embryos, something echoed in the findings that both types of duplications are de novo in just over 50% of cases. Isodicentric chromosome 15 (idic15 or interstitial triplications were not observed in SZ patients or in controls. Overall, this study refines the distinct roles of maternal and paternal interstitial duplications at 15q11.2-q13.3, underlining the critical importance of

Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders

Science.gov (United States)

Isles, Anthony R.; Ingason, Andrés; Lowther, Chelsea; Gawlick, Micha; Stöber, Gerald; Potter, Harry; Georgieva, Lyudmila; Pizzo, Lucilla; Ozaki, Norio; Kushima, Itaru; Ikeda, Masashi; Iwata, Nakao; Levinson, Douglas F.; Gejman, Pablo V.; Shi, Jianxin; Sanders, Alan R.; Duan, Jubao; Sisodiya, Sanjay; Costain, Gregory; Degenhardt, Franziska; Giegling, Ina; Rujescu, Dan; Hreidarsson, Stefan J.; Saemundsen, Evald; Ahn, Joo Wook; Ogilvie, Caroline; Stefansson, Hreinn; Stefansson, Kari; O’Donovan, Michael C.; Owen, Michael J.; Bassett, Anne; Kirov, George

2016-01-01

Duplications at 15q11.2-q13.3 overlapping the Prader-Willi/Angelman syndrome (PWS/AS) region have been associated with developmental delay (DD), autism spectrum disorder (ASD) and schizophrenia (SZ). Due to presence of imprinted genes within the region, the parental origin of these duplications may be key to the pathogenicity. Duplications of maternal origin are associated with disease, whereas the pathogenicity of paternal ones is unclear. To clarify the role of maternal and paternal duplications, we conducted the largest and most detailed study to date of parental origin of 15q11.2-q13.3 interstitial duplications in DD, ASD and SZ cohorts. We show, for the first time, that paternal duplications lead to an increased risk of developing DD/ASD/multiple congenital anomalies (MCA), but do not appear to increase risk for SZ. The importance of the epigenetic status of 15q11.2-q13.3 duplications was further underlined by analysis of a number of families, in which the duplication was paternally derived in the mother, who was unaffected, whereas her offspring, who inherited a maternally derived duplication, suffered from psychotic illness. Interestingly, the most consistent clinical characteristics of SZ patients with 15q11.2-q13.3 duplications were learning or developmental problems, found in 76% of carriers. Despite their lower pathogenicity, paternal duplications are less frequent in the general population with a general population prevalence of 0.0033% compared to 0.0069% for maternal duplications. This may be due to lower fecundity of male carriers and differential survival of embryos, something echoed in the findings that both types of duplications are de novo in just over 50% of cases. Isodicentric chromosome 15 (idic15) or interstitial triplications were not observed in SZ patients or in controls. Overall, this study refines the distinct roles of maternal and paternal interstitial duplications at 15q11.2-q13.3, underlining the critical importance of maternally

22 CFR 133.665 - State.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false State. 133.665 Section 133.665 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 133.665 State. State means any of the States of the United States, the District of...

27 CFR 21.133 - Vinegar.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Vinegar. 21.133 Section 21.133 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS FORMULAS FOR DENATURED ALCOHOL AND RUM Specifications for Denaturants § 21.133 Vinegar. (a...

21 CFR 133.173 - Pasteurized process cheese food.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Pasteurized process cheese food. 133.173 Section 133.173 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific...

Study of the 2H(p,γ)3He reaction in the BBN energy range at LUNA

Science.gov (United States)

Trezzi, Davide; LUNA Collaboration

2018-01-01

Using Big Bang Nucleosynthesis with the recent cosmological parameters obtained by the Planck collaboration, a primordial deuterium abundance value D/H = (2.65 ± 0.07) × 10-5 is obtained. This one is a little bit in tension with astronomical observations on metal- poor damped Lyman alpha systems where D/H = (2.53 ± 0.04) × 105. In order to reduce the BBN calculation uncertainty, a measurement of the 2H(p,γ)3He cross section in the energy range 10-300 keV with a 3% accuracy is thus desirable. Thanks to the low background of the underground Gran Sasso Laboratories, and to the experience accumulated in more than twenty years of scientific activity, LUNA (Laboratory for Underground Nuclear Astrophysics) planned to measure the 2H(p,γ)3He fusion cross section at the BBN energy range in 2015-2016. A feasibility test of the measurement has been recently performed at LUNA. In this paper, the results obtained will be shown. Possible cosmological outcomes from the future LUNA data will be also discussed.

Long range energy transfer in graphene hybrid structures

International Nuclear Information System (INIS)

Gonçalves, Hugo; Bernardo, César; Moura, Cacilda; Belsley, Michael; Schellenberg, Peter; Ferreira, R A S; André, P S; Stauber, Tobias

2016-01-01

In this work we quantify the distance dependence for the extraction of energy from excited chromophores by a single layer graphene flake over a large separation range. To this end hybrid structures were prepared, consisting of a thin (2 nm) layer of a polymer matrix doped with a well chosen strongly fluorescent organic molecule, followed by an un-doped spacer layer of well-defined thicknesses made of the same polymer material and an underlying single layer of pristine, undoped graphene. The coupling strength is assessed through the variation of the fluorescence decay kinetics as a function of distance between the graphene and the excited chromophore molecules. Non-radiative energy transfer to the graphene was observed at distances of up to 60 nm; a range much greater than typical energy transfer distances observed in molecular systems. (paper)

MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16

DEFF Research Database (Denmark)

Yin, Hang; Pasut, Alessandra; Soleimani, Vahab D

2013-01-01

Brown adipose tissue (BAT) is an energy-dispensing thermogenic tissue that plays an important role in balancing energy metabolism. Lineage-tracing experiments indicate that brown adipocytes are derived from myogenic progenitors during embryonic development. However, adult skeletal muscle stem cells...... (satellite cells) have long been considered uniformly determined toward the myogenic lineage. Here, we report that adult satellite cells give rise to brown adipocytes and that microRNA-133 regulates the choice between myogenic and brown adipose determination by targeting the 3'UTR of Prdm16. Antagonism...... of microRNA-133 during muscle regeneration increases uncoupled respiration, glucose uptake, and thermogenesis in local treated muscle and augments whole-body energy expenditure, improves glucose tolerance, and impedes the development of diet-induced obesity. Finally, we demonstrate that miR-133 levels...

21 CFR 133.147 - Grated American cheese food.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Grated American cheese food. 133.147 Section 133.147 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized...

Chemoresistance of CD133(+) colon cancer may be related with increased survivin expression.

Science.gov (United States)

Lee, Mi-Ra; Ji, Sun-Young; Mia-Jan, Khalilullah; Cho, Mee-Yon

2015-07-31

CD133, putative cancer stem cell marker, deemed to aid chemoresistance. However, this claim has been challenged recently and we previously reported that patients with CD133(+) colon cancer have benefit from 5-fluorouracil (5-FU) chemotherapy incontrast to no benefit in patients with CD133(-) cancer. To elucidate the role of CD133 expression in chemoresistance, we silenced the CD133 expression in a colon cancer cell line and determined its effect on the biological characteristics downstream. We comparatively analyzed the sequential changes of MDR1, ABCG2, AKT1 and survivin expression and the result of proliferation assay (WST-1 assay) with 5-FU treatment in CD133(+) and siRNA-induced CD133(-) cells, derived from Caco-2 colon cancer cell line. 5-FU treatment induced significantly increase of the mRNA expression of MDR1, ABCG2 and AKT1genes, but not protein level. CD133 had little to no effect on the mRNA and protein expression of these genes. However, survivin expression at mRNA and protein level were significantly increased in CD133(+) cells compared with siRNA-induced CD133-cells and Mock (not sorted CD133(+) cells) at 96 h after siRNA transfection. The cytotoxicity assay demonstrated notable increase of chemoresistance to 5-FU treatment (10 μM) in CD133(+) cells at 96 h after siRNA transfection. From this study, we conclude that CD133(+) cells may have chemoresistance to 5-FU through the mechanism which is related with survivin expression, instead of MDR1, ABCG2 and AKT1 expression. Therefore a survivin inhibitor can be a new target for effective treatment of CD133(+) colon cancer. Copyright © 2015 Elsevier Inc. All rights reserved.

Measurements of sigma (e+e-→μ+-μ-+) in the energy range 1.2-3.0 GeV

International Nuclear Information System (INIS)

Alles-Borelli, V.; Bernardini, M.; Bollini, D.; Giusti, P.; Massam, T.; Monari, L.; Palmonari, F.; Valenti, G.; Zichichi, A.

1975-01-01

The analysis of 1466 events of the type e + e - →μ +- μ -+ , in the time-like range from 1.44 to 9.00 GeV 2 , shows that the absolute value of the cross-section and its energy dependence follow QED expectations within (+- 3.2%) and (+- 1.2%), respectively. (Auth.)

Chemoresistance of CD133{sup +} colon cancer may be related with increased survivin expression

Energy Technology Data Exchange (ETDEWEB)

Lee, Mi-Ra; Ji, Sun-Young; Mia-Jan, Khalilullah [Department of Pathology, Yonsei University, Wonju College of Medicine, Wonju (Korea, Republic of); Cho, Mee-Yon, E-mail: meeyon@yonsei.ac.kr [Department of Pathology, Yonsei University, Wonju College of Medicine, Wonju (Korea, Republic of); Institute of Genomic Cohort, Yonsei University, Wonju College of Medicine, Wonju (Korea, Republic of)

2015-07-31

CD133, putative cancer stem cell marker, deemed to aid chemoresistance. However, this claim has been challenged recently and we previously reported that patients with CD133{sup +} colon cancer have benefit from 5-fluorouracil (5-FU) chemotherapy incontrast to no benefit in patients with CD133{sup −} cancer. To elucidate the role of CD133 expression in chemoresistance, we silenced the CD133 expression in a colon cancer cell line and determined its effect on the biological characteristics downstream. We comparatively analyzed the sequential changes of MDR1, ABCG2, AKT1 and survivin expression and the result of proliferation assay (WST-1 assay) with 5-FU treatment in CD133{sup +} and siRNA-induced CD133{sup −} cells, derived from Caco-2 colon cancer cell line. 5-FU treatment induced significantly increase of the mRNA expression of MDR1, ABCG2 and AKT1genes, but not protein level. CD133 had little to no effect on the mRNA and protein expression of these genes. However, survivin expression at mRNA and protein level were significantly increased in CD133{sup +} cells compared with siRNA-induced CD133-cells and Mock (not sorted CD133{sup +} cells) at 96 h after siRNA transfection. The cytotoxicity assay demonstrated notable increase of chemoresistance to 5-FU treatment (10 μM) in CD133{sup +} cells at 96 h after siRNA transfection. From this study, we conclude that CD133{sup +} cells may have chemoresistance to 5-FU through the mechanism which is related with survivin expression, instead of MDR1, ABCG2 and AKT1 expression. Therefore a survivin inhibitor can be a new target for effective treatment of CD133{sup +} colon cancer. - Highlights: • We evaluate the role of CD133 in chemoresistance of colon cancer. • We compared the chemoresistance of CD133{sup +} cells and siRNA-induced CD133{sup −} cells. • CD133 had little to no effect on MDR1, ABCG2 and AKT1 expression. • Survivin expression and chemoresistance were increased in CD133{sup +} colon cancer cells.

Measurement of D(d,p)T Reaction Cross Sections in Sm Metal in Low Energy Region (10(≤) Ed(≤)20 keV)

Institute of Scientific and Technical Information of China (English)

WANG Tie-Shan; YANG Zhen; H. Yunemura; A. Nakagawa; LV Hui-Yi; CHEN Jian-Yong; LIU Sheng-Jin; J. Kasagi

2007-01-01

To study the screening effect of nuclear reactions in metallic environments, the thick target yields, the cross sections and the experimental S(E) factors of the D{d,p)T reaction have been measured on deuterons implanted in Sm metal at 133.2 K for beam energies ranging from 10 to 20keV. The thick target yields of protons emitted in the D(d,p)T reaction are measured and compared with those data extrapolated from cross sections and stopping power data at higher energies. The screening potential in Sm metal at 133.2K is deduced to be 520±56eV. As compared with the value achieved in the gas target, the calculated screening potential values are much larger. This screening potential cannot be simply interpreted only by the electron screening. Energy dependences of the cross section cr(E) and the experimental S(E) factor for D(d,p)T reaction in Sm metal at 133.2K are obtained, respectively.

An improved energy-range relationship for high-energy electron beams based on multiple accurate experimental and Monte Carlo data sets

International Nuclear Information System (INIS)

Sorcini, B.B.; Andreo, P.; Hyoedynmaa, S.; Brahme, A.; Bielajew, A.F.

1995-01-01

A theoretically based analytical energy-range relationship has been developed and calibrated against well established experimental and Monte Carlo calculated energy-range data. Only published experimental data with a clear statement of accuracy and method of evaluation have been used. Besides published experimental range data for different uniform media, new accurate experimental data on the practical range of high-energy electron beams in water for the energy range 10-50 MeV from accurately calibrated racetrack microtrons have been used. Largely due to the simultaneous pooling of accurate experimental and Monte Carlo data for different materials, the fit has resulted in an increased accuracy of the resultant energy-range relationship, particularly at high energies. Up to date Monte Carlo data from the latest versions of the codes ITS3 and EGS4 for absorbers of atomic numbers between four and 92 (Be, C, H 2 O, PMMA, Al, Cu, Ag, Pb and U) and incident electron energies between 1 and 100 MeV have been used as a complement where experimental data are sparse or missing. The standard deviation of the experimental data relative to the new relation is slightly larger than that of the Monte Carlo data. This is partly due to the fact that theoretically based stopping and scattering cross-sections are used both to account for the material dependence of the analytical energy-range formula and to calculate ranges with the Monte Carlo programs. For water the deviation from the traditional energy-range relation of ICRU Report 35 is only 0.5% at 20 MeV but as high as - 2.2% at 50 MeV. An improved method for divergence and ionization correction in high-energy electron beams has also been developed to enable use of a wider range of experimental results. (Author)

Examination of post operative split lung function using quantitative xenon 133 (133Xe) inhalation scan

International Nuclear Information System (INIS)

Omote, Yoshiharu; Maeda, Tomio; Ikeda, Koichiro; Kubo, Yoshihiko

1992-01-01

133 Xe inhalation scan and ordinary lung function testing were performed three times in 34 patients undergoing pulmonary resection: before surgery, and one and six months postoperatively. Forced vital capacity (FVC) and forced expiratory volume in the first second (FEV 1.0 ) were used as spirometric parameters. From the 133 Xe inhalation scan, a split lung capacity (right to left, upper, middle and lower) and T1/2 (time required for half of the inhalation of 133 Xe gas to be expired) were calculated by computer and used as indices of split lung capacity and ventilation, respectively. The predicted postoperative lung functions were calculated using preoperative spirometric respiratory function and 133 Xe inhalation data according to the formula reported by Ali and associates. At sixth postoperative month, both predicted FVC (r=0.895, p 1.0 (r=0.897, p<0.001) correlated highly with those actually observed. These results appear to be very useful for preoperative evaluation of operative indications and the choice of surgical method. The ratios of observed to predicted lung capacity in the post operative state were examined by splitting the right and left lung and the means±S.D.(%) were 80.5±9.7% on the operated side and 119.2±11.7% on the opposite side one month after surgery. Six months after surgery, the corresponding figures were 111.0±5.6% and 96.7±16.4%. The post operative T1/2 values on the operated sides were about 2.4 times the preoperative values at one month after surgery but returned to the preoperative values by the six postoperative month. From these results, it can be said that respiratory functions after pulmonary resection are maintained primarily by compensatory lung function of opposite and operated sides at one and six months, respectively. These results also provide valuable information on postoperative respiratory care for patients who have undergone lung resection. (author)

Binding characteristics of 9-fluoropropyl-(+)-dihydrotetrabenzazine (AV-133) to the vesicular monoamine transporter type 2 in rats

Energy Technology Data Exchange (ETDEWEB)

Tsao, H.-H. [Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan (China); Lin, K.-J. [Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan (China); Department of Nuclear Medicine, Chang Gung University and Memorial Hospital, Taoyuan, Taiwan (China); Juang, J.-H. [Division of Endocrinology and Metabolism, Chung Gung University and Chung Gung Memorial Hospital, Taoyuan, Taiwan (China); Skovronsky, Daniel M. [Avid Radiopharmaceuticals, Philadelphia, PA (United States); Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 (United States); Yen, T.-C. [Department of Nuclear Medicine, Chang Gung University and Memorial Hospital, Taoyuan, Taiwan (China); Wey, S.-P. [Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan (China); Kung, M.-P. [Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan (China); Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 (United States)], E-mail: kungmp@sunmac.spect.upenn.edu

2010-05-15

The vesicular monoamine transporter type 2 (VMAT2) is highly expressed in pancreatic {beta}-cells and thus has been proposed to be a potential target for measuring {beta}-cell mass (BCM) by molecular imaging. C-11- and F-18-labeled tetrabenazine derivatives targeting VMAT2 have shown some promising results as potential biomarkers for BCM. In the present study, we examined the binding characteristics of 9-fluoropropyl-(+)-dihydrotetrabenzazine ([{sup 18}F]AV-133), a potential PET tracer for BCM imaging, in rat pancreas and rat brain. Methods: Pancreatic exocrine cells and pancreatic islet cells were isolated and purified from Sprague-Dawley rats. Membrane homogenates, prepared from both pancreatic exocrine and islet cells as well as from brain striatum and hypothalamus regions, were used for in vitro binding studies. In vitro and ex vivo autoradiography studies with [{sup 18}F]AV-133 were performed on rat brain and rat pancreas sections. Immunohistochemistry studies were performed to confirm the distribution of VMAT2 on islet {beta}-cells. Results: Excellent binding affinities of [{sup 18}F]AV-133 were observed in rat striatum and hypothalamus homogenates with K{sub d} values of 0.19 and 0.25 nM, respectively. In contrast to single-site binding observed in rat striatum homogenates, rat islet cell homogenates showed two saturable binding sites (site A: K{sub d}=6.76 nM, B{sub max}=60 fmol/mg protein; site B: K{sub d}=241 nM, B{sub max}=1500 fmol/mg protein). Rat exocrine pancreas homogenates showed only a single low-affinity binding site (K{sub d}=209 nM), which was similar to site B in islet cells. In vitro autoradiography of [{sup 18}F]AV-133 using frozen sections of rat pancreas showed specific labeling of islets, as evidenced by co-localization with anti-insulin antibody. Ex vivo VMAT2 pancreatic autoradiography in the rat, however, was not successful, in contrast to the excellent ex vivo autoradiography of VMAT2 binding sites in the brain. In vivo/ex vivo islet

STARCODES, Stopping Power and Ranges for Electrons, Protons, He

International Nuclear Information System (INIS)

2000-01-01

1 - Description of program or function: The 'STAR CODES', ESTAR, PSTAR, and ASTAR, calculate stopping-power and range tables for electrons, protons, and helium ions (alphas), according to methods described in ICRU Reports 37 and 39. 2 - Method of solution: Collision stopping powers are calculated from the theory of Bethe (1930, 1932), with a density-effect correction evaluated according to Sternheimer (1952, 1982). The stopping-power formula contains an important parameter, the mean excitation energy (I-value), which characterizes the stopping properties of a material. The codes provide output for electrons in any stopping material (279 provided) and for protons and helium ions in 74 materials. The calculations include the 1) Collision stopping power, 2) Radiative stopping power (electrons only), 3) Nuclear stopping power (protons and helium ions), 4) Total stopping power, 5) CSDA range, 6) Projected range (protons and helium ions), 7) Density effect parameter (electrons), 8) Radiation yield (electrons), and 9) Detour factor (protons and helium ions). Standard energy grids and files of elements w/ionization-excitation information are included with lookup table capabilities. 3 - Restrictions on the complexity of the problem: The minimum energies used in the calculations are at 1 KeV (protons and helium ions) and 10 KeV (electrons), and the maximum are 1 GeV. The standard energy grids are set at 81 for electrons, equally spaced (logarithmically), 133 for protons, and 122 for helium ions. The lower energy electron calculations (< 10 KeV) have up to 5-10% errors and are considered too fallable

Total cross sections for electron scattering by CO2 molecules in the energy range 400 endash 5000 eV

International Nuclear Information System (INIS)

Garcia, G.; Manero, F.

1996-01-01

Total cross sections for electron scattering by CO 2 molecules in the energy range 400 endash 5000 eV have been measured with experimental errors of ∼3%. The present results have been compared with available experimental and theoretical data. The dependence of the total cross sections on electron energy shows an asymptotic behavior with increasing energies, in agreement with the Born-Bethe approximation. In addition, an analytical formula is provided to extrapolate total cross sections to higher energies. copyright 1996 The American Physical Society

Scintillation Response of CaF2 to H and He over a Continuous Energy Range

International Nuclear Information System (INIS)

Zhang, Yanwen; Xiang, Xia; Weber, William J.

2008-01-01

Recent demands for new radiation detector materials with improved γ-ray detection performance at room temperature have prompted research efforts on both accelerated material discovery and efficient techniques that can be used to identify material properties relevant to detector performance. New material discovery has been limited due to the difficulties of large crystal growth to completely absorb γ-energies; whereas high-quality thin films or small crystals of candidate materials can be readily produced by various modern growth techniques. In this work, an ion-scintillator technique is demonstrated that can be applied to study scintillation properties of thin films and small crystals. The scintillation response of a benchmark scintillator, europium-doped calcium fluoride (CaF2:Eu), to energetic proton and helium ions is studied using the ion-scintillator approach based on a time of flight (TOF) telescope. Excellent energy resolution and fast response of the TOF telescope allow quantitative measurement of light yield, nonlinearity and energy resolution over an energy range from a few tens to a few thousands of keV

Flow measurements in biological systems using Xe-127 and Xe-133

International Nuclear Information System (INIS)

Tripathi, R.R.

1981-01-01

Xe-133 and Xe-127 are widely used for quantitative evaluation of ventilation in human subjects. Owing to differences in scattering in the biological system as well as differences in the detector response to photons of selected energies, clinical Xe-133 images are much more distorted than the corresponding Xe-127 images. This thesis concerns itself with the evaluation of Xe-133 and Xe-127 as potential tracers for pulmonary function studies. Through the simulation of clinical images it is shown that such smaller abnormalities are able to be detected with Xe-127 than with Xe-133. It is also found that even for poorly ventilated regions, the measured lesion size in the simulated image is comparable to the known lesion size when studied with Xe-127. With Xe-133, however, the measured size of the lesion is smaller than its known size. By fitting the washout portion of the clinical data to a linear sum of two exponentials, a weighted average clearance constant for the tracer - which relates to the reciprocal of the mean flow through the system - can be calculated and used as an index for comparison of the two Xenon isotopes. When an appropriate model is used for data interpretation, more accurate clinical information can be derived from the Xe-127 data. Unlike Xe-133, ventilation study with Xe-127 can be performed immediately after the perfusion study with Tc-99m. Lower radiation dose and longer shelf-life of Xe-127 are added advantages over Xe-133. Various compartmental and non-compartmental models are examined and appropriate technique(s) for clinical data interpretation is(are) recommended

Long-range prospects of world energy demands and future energy sources

International Nuclear Information System (INIS)

Kozaki, Yasuji

1998-01-01

The long-range prospects for world energy demands are reviewed, and the major factors which are influential in relation to energy demands are discussed. The potential for various kinds of conventional and new energy sources such as fossil fuels, solar energies, nuclear fission, and fusion energies to need future energy demands is also discussed. (author)

47 CFR 25.133 - Period of construction; certification of commencement of operation.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false Period of construction; certification of commencement of operation. 25.133 Section 25.133 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Applications and Licenses Earth Stations § 25.133 Period...

46 CFR 133.105 - Survival craft.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Survival craft. 133.105 Section 133.105 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS Requirements for All OSVs § 133.105 Survival craft. (a) Each survival craft must be approved and equipped as...

CD133 antibody conjugation to decellularized human heart valves intended for circulating cell capture.

Science.gov (United States)

Vossler, John D; Min Ju, Young; Williams, J Koudy; Goldstein, Steven; Hamlin, James; Lee, Sang Jin; Yoo, James J; Atala, Anthony

2015-09-03

The long term efficacy of tissue based heart valve grafts may be limited by progressive degeneration characterized by immune mediated inflammation and calcification. To avoid this degeneration, decellularized heart valves with functionalized surfaces capable of rapid in vivo endothelialization have been developed. The aim of this study is to examine the capacity of CD133 antibody-conjugated valve tissue to capture circulating endothelial progenitor cells (EPCs). Decellularized human pulmonary valve tissue was conjugated with CD133 antibody at varying concentrations and exposed to CD133 expressing NTERA-2 cl.D1 (NT2) cells in a microflow chamber. The amount of CD133 antibody conjugated on the valve tissue surface and the number of NT2 cells captured in the presence of shear stress was measured. Both the amount of CD133 antibody conjugated to the valve leaflet surface and the number of adherent NT2 cells increased as the concentration of CD133 antibody present in the surface immobilization procedure increased. The data presented in this study support the hypothesis that the rate of CD133(+) cell adhesion in the presence of shear stress to decellularized heart valve tissue functionalized by CD133 antibody conjugation increases as the quantity of CD133 antibody conjugated to the tissue surface increases.

Energy efficiency and CO_2 mitigation potential of the Turkish iron and steel industry using the LEAP (long-range energy alternatives planning) system

International Nuclear Information System (INIS)

Ates, Seyithan A.

2015-01-01

With the assistance of the LEAP (long-range energy alternatives planning) energy modeling tool, this study explores the energy efficiency and CO_2 emission reduction potential of the iron and steel industry in Turkey. With a share of 35%, the steel and iron industry is considered as the most energy-consuming sector in Turkey. The study explores that the energy intensity rate can be lowered by 13%, 38% and 51% in SEI (slow-speed energy efficiency improvement), AEI (accelerating energy efficiency improvement) and CPT (cleaner production and technology scenario) scenarios, respectively. Particularly the projected aggregated energy savings of the scenarios CPT and AES are very promising with saving rates of 33.7% and 23% respectively. Compared to baseline scenarios, energy efficiency improvements correspond to economic potential of 0.1 billion dollars for SEI, 1.25 dollars for AEI and 1.8 billion dollars for CPT scenarios annually. Concerning GHG (greenhouse gas) emissions, in 2030 the iron and steel industry in Turkey is estimated to produce 34.9 MtCO_2 in BAU (business-as-usual scenario), 32.5 MtCO_2 in SEI, 24.6 MtCO_2 in AEI and 14.5 MtCO_2 in CPT a scenario which corresponds to savings of 9%–39%. The study reveals that energy consumption and GHG emissions of the iron and steel industry can be lowered significantly if the necessary measures are implemented. It is expected that this study will fill knowledge gaps pertaining to energy efficiency potential in Turkish energy intensive industries and help stakeholders in energy intensive industries to realize the potential for energy efficiency and GHG mitigation. - Highlights: • This paper explores energy efficiency potential of iron and Steel industry in Turkey. • We applied the LEAP modeling to forecast future developments. • Four different scenarios have been developed for the LEAP modeling. • There is a huge potential for energy efficiency and mitigation of GHG emissions.

46 CFR 133.135 - Rescue boats.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Rescue boats. 133.135 Section 133.135 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS Requirements for All OSVs § 133.135 Rescue boats. (a) Each OSV must carry at least one rescue boat. Each rescue...

49 CFR 383.133 - Testing methods.

Science.gov (United States)

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Testing methods. 383.133 Section 383.133... STANDARDS; REQUIREMENTS AND PENALTIES Tests § 383.133 Testing methods. (a) All tests shall be constructed in... must be at least as stringent as the Federal standards. (c) States shall determine specific methods for...

The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells.

Directory of Open Access Journals (Sweden)

Erika Bourseau-Guilmain

Full Text Available As the pentaspan stem cell marker CD133 was shown to bind cholesterol and to localize in plasma membrane protrusions, we investigated a possible function for CD133 in endocytosis. Using the CD133 siRNA knockdown strategy and non-differentiated human colon cancer Caco-2 cells that constitutively over-expressed CD133, we provide for the first time direct evidence for a role of CD133 in the intracellular accumulation of fluorescently labeled extracellular compounds. Assessed using AC133 monoclonal antibody, CD133 knockdown was shown to improve Alexa488-transferrin (Tf uptake in Caco-2 cells but had no impact on FITC-dextran or FITC-cholera-toxin. Absence of effect of the CD133 knockdown on Tf recycling established a role for CD133 in inhibiting Tf endocytosis rather than in stimulating Tf exocytosis. Use of previously identified inhibitors of known endocytic pathways and the positive impact of CD133 knockdown on cellular uptake of clathrin-endocytosed synthetic lipid nanocapsules supported that CD133 impact on endocytosis was primarily ascribed to the clathrin pathway. Also, cholesterol extraction with methyl-β-cyclodextrine up regulated Tf uptake at greater intensity in the CD133(high situation than in the CD133(low situation, thus suggesting a role for cholesterol in the inhibitory effect of CD133 on endocytosis. Interestingly, cell treatment with the AC133 antibody down regulated Tf uptake, thus demonstrating that direct extracellular binding to CD133 could affect endocytosis. Moreover, flow cytometry and confocal microscopy established that down regulation of CD133 improved the accessibility to the TfR from the extracellular space, providing a mechanism by which CD133 inhibited Tf uptake. As Tf is involved in supplying iron to the cell, effects of iron supplementation and deprivation on CD133/AC133 expression were investigated. Both demonstrated a dose-dependent down regulation here discussed to the light of transcriptional and post

CD133 positive U87 glioma stem cell radiosensitivity and DNA double-strand break repair

International Nuclear Information System (INIS)

Li Ping; Zong Tianzhou; Ji Xiaoqin; Lu Xueguan

2013-01-01

Objective: To explore the radiosensitivity and DNA double-strand break repair of CD133 + U87 glioma stem cell. Methods: CD133 + and CD133 - cells were isolated from glioma U87 cell lines by flow cytometry sorter system. After irradiated vertically by 4 Gy X-rays, the radiosensitivity of cells was determined by clonogenic assay. The radiation-induced DNA double-strand break repair of CD133 + and CD133 - cells was determined by the neutral comet assay,and the expression of phosphorylated histone H2AX (γ-H2AX) and Rad51 foci were measured by immunofluorescence. Results: The clone forming rate of CD133 + cells was higher than CD133 - cells (t=3.66, P<0.01) with no radiation. The clone forming rate of CD133 + cells irradiated by 4 Gy X-rays has no significant changes compared to that of the non-irradiation cells (t=0.71, P>0.05), but for CD133 - cells, it decreased compared to non-irradiation cells (t=2.91, P<0.05). The tailmoment between CD133 + cells and CD133 - cells had no difference at 0.5 h after irradiation (t=1.44, P>0.05); the tailmoment of CD133 + cells was lower than CD133 - cells at 6 and 24 h after irradiation,respectively (t=5.31 and 8.09, P<0.01). There was no significant difference in the expression of γ-H2AX foci between CD133 + and CD133 - cells at 0.5 and 6 h after irradiation (t=0.12 and 0.99, P>0.05), γ-H2AX foci of CD133 + cells was significantly decreased compared to CD133 - cells at 24 h after irradiation (t=4.99, P<0.01). For Rad 51 foci, there was no difference between CD133 + and CD133 - cells at 0.5 h after irradiation (t=1.12, P>0.05). The expression of Rad 51 foci of CD133 - cells was decreased compared to that of CD133 + cells at 6 and 24 h after irradiation,respectively (t=22.88 and 12.43, P<0.01). And the expression of Rad51 foci of CD133 + cells had no significant changes at 6-24 h after irradiation. Conclusions: Glioma stem cells is more radioresistive than glioma non-stem cells. The probable mechanism is that the DNA double

Alternative separation of exchange and correlation energies in multi-configuration range-separated density-functional theory.

Science.gov (United States)

Stoyanova, Alexandrina; Teale, Andrew M; Toulouse, Julien; Helgaker, Trygve; Fromager, Emmanuel

2013-10-07

The alternative separation of exchange and correlation energies proposed by Toulouse et al. [Theor. Chem. Acc. 114, 305 (2005)] is explored in the context of multi-configuration range-separated density-functional theory. The new decomposition of the short-range exchange-correlation energy relies on the auxiliary long-range interacting wavefunction rather than the Kohn-Sham (KS) determinant. The advantage, relative to the traditional KS decomposition, is that the wavefunction part of the energy is now computed with the regular (fully interacting) Hamiltonian. One potential drawback is that, because of double counting, the wavefunction used to compute the energy cannot be obtained by minimizing the energy expression with respect to the wavefunction parameters. The problem is overcome by using short-range optimized effective potentials (OEPs). The resulting combination of OEP techniques with wavefunction theory has been investigated in this work, at the Hartree-Fock (HF) and multi-configuration self-consistent-field (MCSCF) levels. In the HF case, an analytical expression for the energy gradient has been derived and implemented. Calculations have been performed within the short-range local density approximation on H2, N2, Li2, and H2O. Significant improvements in binding energies are obtained with the new decomposition of the short-range energy. The importance of optimizing the short-range OEP at the MCSCF level when static correlation becomes significant has also been demonstrated for H2, using a finite-difference gradient. The implementation of the analytical gradient for MCSCF wavefunctions is currently in progress.

Gamma-ray astronomy in the medium energy (10-50 MeV) range

International Nuclear Information System (INIS)

Kniffen, D.A.; Bertsch, D.L.; Palmeira, R.A.R.; Rao, K.R.

1977-01-01

Gamma-ray astronomy in the medium energy (10-50 MeV) range can provide unique information with which to study many astrophysical problems. Observations in the 10-50 MeV range provide the cleanest window with which to view the isotropic diffuse component of the radiation and to study the possible cosmological implications of the spectrum. For the study of compact sources, this is the important region between the X-ray sky and the vastly different γ-ray sky seen by SAS-2 and COS-B. To understand the implications of medium energy γ-ray astronomy to the study of the galactic diffuse γ-radiation, the model developed to explain the high energy γ-ray observations of SAS-2 is extended to the medium energy range. This work illustrates the importance of medium energy γ-ray astronomy for studying the electromagnetic component of the galactic cosmic rays. To observe the medium energy component of the intense galactic center γ-ray emission, two balloon flights of a medium energy γ-ray spark chamber telescope were flown in Brazil in 1975. These results indicate the emission is higher than previously thought and above the predictions of the theoretical model

65Zn and 133Ba standardizing by photon-photon coincidence counting

International Nuclear Information System (INIS)

Loureiro, Jamir S.; Cruz, Paulo A.L. da; Iwahara, Akira; Delgado, José U.; Lopes, Ricardo T.

2017-01-01

The LNMRI/Brazil has deployed a system using X-gamma coincidence technique for the standardizing radionuclide, which present simple and complex decay scheme with X-rays of energy below 100 keV. The work was carried on radionuclide metrology laboratory using a sodium iodide detector, for gamma photons, in combination with a high purity germanium detector for X-rays. Samples of 65 Zn and 133 Ba were standardized and the results for both radionuclides showed good precision and accuracy when compared with reference values. The standardization differences were 0.72 % for 65 Zn and 0.48 % for 133 Ba samples. (author)

65Zn and 133Ba standardizing by photon-photon coincidence counting

Science.gov (United States)

Loureiro, Jamir S.; da Cruz, Paulo A. L.; Iwahara, Akira; Delgado, José U.; Lopes, Ricardo T.

2018-03-01

The LNMRI/Brazil has deployed a system using X-gamma coincidence technique for the standardizing radionuclide, which present simple and complex decay scheme with X-rays of energy below 100 keV. The work was carried on radionuclide metrology laboratory using a sodium iodide detector, for gamma photons, in combination with a high purity germanium detector for X-rays. Samples of 65Zn and 133Ba were standardized and the results for both radionuclides showed good precision and accuracy when compared with reference values. The standardization differences were 0.72 % for 65Zn and 0.48 % for 133Ba samples.

DM2 results on e+e- annihilation into multihadrons in the 1350-2400 MeV energy range

International Nuclear Information System (INIS)

Bisello, D.; Busetto, G.; Castro, A.; Nigro, M.; Pescara, L.; Sartori, P.; Stanco, L.; Antonelli, A.; Baldini, R.; Biagini, M.E.; Calcaterra, A.; Schioppa, M.; Augustin, J.E.; Cosme, G.; Couchot, F.; Fulda, F.; Grosdidier, G.; Jean-Marie, B.; Lepeltier, V.; Szklarz, G.

1990-06-01

We present preliminary results on the study of e + e - annihilation into π + π - π + π - , π + π - π 0 π 0 , π + π - π 0 , π + π - π + π - π 0 , K + K - π + π - and K s 0 K ± π -+ in the 1350-2400 MeV energy range. Data have been collected with the DM2 detector at DCI, the Orsay colliding ring, and refer to about 2 pb -1 integrated luminosity

/sup 133/Xe clearance of the knee joint of patients suffering from arthritis and osteoarthrosis

Energy Technology Data Exchange (ETDEWEB)

Balint, G.; Reviczky, L.A.; Lendvay, J.; Boehm, U.; Kucsera, K.; Genti, Gy. (Orszagos Reuma es Fizioterapias Intezet, Budapest (Hungary))

1982-01-01

65 inflammed and 13 non-inflammed knee joints of patients suffering from osteoarthrosis were examined by the Xe/sup 133/ clearance method. The control group consisted of 27 patients with exsudative arthritis of the knee. The counts of 80 ..mu..C /sup 133/Xe given intraarticcularly were measured above the knee joint by NK 350 energy selective counter. The time needed to halve the count rate measured in the 4th minute after administration (biological half life (T1/2)) was significantly different in the three groups. It was the longest in the non-inflammed arthrosis, the shortest in the exsudative arthritis group. Significant differences were apparent regarding joint pain and tenderness in all the three groups. Though the synovial protein level and the C/sub 3/ complement level were significantly different, in the three groups no relationship was found between the T1/2 and synovial/serum protein ratio or between the synovial/serum C/sub 3/ ratio. The authors concluded that /sup 133/Xe clearance, which measures the perfusion of the synovial membrane, can be used for measuring the inflammatory activity of knee joint synovitis.

The inclusion of long-range polarisation functions in calculations of low-energy e+-H2 scattering using the Kohn method

International Nuclear Information System (INIS)

Armour, E.A.G.; Plummer, M.

1989-01-01

An explanation is given of why it is necessary to include long-range polarisation functions in the trial function when carrying out Kohn calculations of low-energy positron (and electron) scattering by atoms and simple molecules. The asymptotic form of these functions in low-energy e + -H 2 scattering is deduced. Appropriate functions with this asymptotic form are used to represent the closed-channel part of the wavefunction in a Kohn calculation of the lowest partial wave of Σ u + symmetry in e + -H 2 scattering at very low energies. For k≤0.03a 0 -1 , the results obtained are in good agreement with those obtained using the Born approximation and the asymptotic forms of the static and polarisation potentials. The relationship is pointed out between this method of taking into account long-range polarisation and the polarised pseudostate method used in R-matrix calculations. (author)

Range energy for heavy ions in CR-39

International Nuclear Information System (INIS)

Gil, L.R.; Marques, A.

1987-01-01

Range-energy relations in CR-39, for ions from He to Ar, are obtained after their effective nuclear charge. Comparison with earlier calculations and numerical results in the energy range 0,1 to 200 Mev/ Nucleon are also given. (M.W.O.)

The total release of xenon-133 from the Fukushima Dai-ichi nuclear power plant accident

International Nuclear Information System (INIS)

Stohl, Andreas; Seibert, Petra; Wotawa, Gerhard

2012-01-01

The accident at the Fukushima Dai-ichi nuclear power plant (FD-NPP) on 11 March 2011 released large amounts of radioactivity into the atmosphere. We determine the total emission of the noble gas xenon-133 ( 133 Xe) using global atmospheric concentration measurements. For estimating the emissions, we used three different methods: (i) using a purely observation-based multi-box model, (ii) comparisons of dispersion model results driven with GFS meteorological data with the observation data, and (iii) such comparisons with the dispersion model driven by ECMWF data. From these three methods, we have obtained total 133 Xe releases from FD-NPP of (i) 16.7 ± 1.9 EBq, (ii) 14.2 ± 0.8 EBq, and (iii) 19.0 ± 3.4 EBq, respectively. These values are substantially larger than the entire 133 Xe inventory of FD-NPP of about 12.2 EBq derived from calculations of nuclear fuel burn-up. Complete release of the entire 133 Xe inventory of FD-NPP and additional release of 133 Xe due to the decay of iodine-133 ( 133 I), which can add another 2 EBq to the 133 Xe FD-NPP inventory, is required to explain the atmospheric observations. Two of our three methods indicate even higher emissions, but this may not be a robust finding given the differences between our estimates. - Highlights: ► We determine the total release of xenon-133 from the Fukushima nuclear accident. ► We used global measurements and a box model, as well as dispersion model estimates. ► Total 133 Xe release is about 14.2-19 EBq, more than Fukushima 133 Xe inventory. ► Additional release of iodine-133 and decay into 133 Xe needed to explain results.

Possibility of a 4He2 bound state, effective range theory, and very low energy He--He scattering

International Nuclear Information System (INIS)

Uang, Y.; Stwalley, W.C.

1982-01-01

The best available intermolecular potential for helium by Aziz, Nain, Carley, Taylor, and McConville is shown here for the first time to have a 4 He 2 bound state. Two numerical analyses, namely, eigenvalue solution and effective range theory, are used to support this conclusion. Unlike usual chemically bound species, the binding energy of this very weakly bound level is found to be only 8.3 x 10 -4 K, which is four orders of magnitude smaller than the potential well depth epsilon = 10.8 K. The scattering length for He+He collisions, determined from effective range theory, is used to calculate the elastic cross section in the very low energy limit. The results (1.878 x 10 5 A 2 for 4 He+ 4 He and 6.035 x 10 2 A for 3 He+ 3 He) are consistent with measurements at the lowest velocities yet attained. In terms of the estimated uncertainties of the parameters of the potential of Aziz and co-workers, it is shown that it is very likely that a bound state of the 4 He 2 molecule does in fact exist

Page | 133 LEGISLATIVE APPROVAL OF EXECUTIVE ...

African Journals Online (AJOL)

Fr. Ikenga

NAUJILJ 9 (2) 2018. Page | 133 ... Keywords: Executive appointments, Legislative approval, National Assembly, Constitutional duty. 1. ... Representatives is led by a Speaker.6 The election of the leadership of the senate is entirely the affair of.

NEUTRON-PROTON EFFECTIVE RANGE PARAMETERS AND ZERO-ENERGY SHAPE DEPENDENCE.

Energy Technology Data Exchange (ETDEWEB)

HACKENBURG, R.W.

2005-06-01

A completely model-independent effective range theory fit to available, unpolarized, np scattering data below 3 MeV determines the zero-energy free proton cross section {sigma}{sub 0} = 20.4287 {+-} 0.0078 b, the singlet apparent effective range r{sub s} = 2.754 {+-} 0.018{sub stat} {+-} 0.056{sub syst} fm, and improves the error slightly on the parahydrogen coherent scattering length, a{sub c} = -3.7406 {+-} 0.0010 fm. The triplet and singlet scattering lengths and the triplet mixed effective range are calculated to be a{sub t} = 5.4114 {+-} 0.0015 fm, a{sub s} = -23.7153 {+-} 0.0043 fm, and {rho}{sub t}(0,-{epsilon}{sub t}) = 1.7468 {+-} 0.0019 fm. The model-independent analysis also determines the zero-energy effective ranges by treating them as separate fit parameters without the constraint from the deuteron binding energy {epsilon}{sub t}. These are determined to be {rho}{sub t}(0,0) = 1.705 {+-} 0.023 fm and {rho}{sub s}(0,0) = 2.665 {+-} 0.056 fm. This determination of {rho}{sub t}(0,0) and {rho}{sub s}(0,0) is most sensitive to the sparse data between about 20 and 600 keV, where the correlation between the determined values of {rho}{sub t}(0,0) and {rho}{sub s}(0,0) is at a minimum. This correlation is responsible for the large systematic error in r{sub s}. More precise data in this range are needed. The present data do not event determine (with confidence) that {rho}{sub t}(0,0) {ne} {rho}{sub t}(0, -{epsilon}{sub t}), referred to here as ''zero-energy shape dependence''. The widely used measurement of {sigma}{sub 0} = 20.491 {+-} 0.014 b from W. Dilg, Phys. Rev. C 11, 103 (1975), is argued to be in error.

9 CFR 3.133 - Separation.

Science.gov (United States)

2010-01-01

... Warmblooded Animals Other Than Dogs, Cats, Rabbits, Hamsters, Guinea Pigs, Nonhuman Primates, and Marine... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Separation. 3.133 Section 3.133 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL...

Imaging yield from 133 consecutive patients with prostate cancer and low trigger PSA from a single institution

International Nuclear Information System (INIS)

Shinagare, A.B.; Keraliya, A.; Somarouthu, B.; Tirumani, S.H.; Ramaiya, N.H.; Kantoff, P.W.

2016-01-01

Aim: To investigate the yield of imaging in patients with relapsed prostate cancer (PC) with a low trigger prostate-specific antigen (PSA). Materials and methods: This institutional review board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study included all 133 patients (mean age 68 years; range 45–88; median 69 months since original diagnosis; interquartile range [IQR]: 32–139) with hormone-sensitive PC (HSPC, n=28) or castration-resistant PC (CRPC, n=105) and trigger PSA 0.05 for all). Fifty-seven of the 133 (43%) patients had findings seen only at CT, of which 37 had new extra-osseous findings. Only 2/133 (2%) had findings at bone scintigraphy not seen at CT, both in areas not covered on CT. Conclusion: Imaging frequently demonstrated new metastatic and non-metastatic findings in patients with a low trigger PSA. CT is valuable in these patients because extra-osseous findings not visible at bone scintigraphy are frequently seen. - Highlights: • New and existing metastases common in prostate cancer with low trigger PSA. • Previous reports of threshold PSA levels may not apply in follow-up setting. • No difference in metastatic pattern between hormone sensitive and resistant disease. • CT showed extra-osseous findings not seen on bone scan in 44% patients. • Bone scan rarely showed findings not visible on concurrent CT.

29 CFR 1990.133 - Publication.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Publication. 1990.133 Section 1990.133 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED... Publication. (a) The Secretary shall publish the Candidate List in the Federal Register at least annually. (b...

46 CFR 133.70 - Personal lifesaving appliances.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Personal lifesaving appliances. 133.70 Section 133.70 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS Requirements for All OSVs § 133.70 Personal lifesaving appliances. (a) Lifebuoys. Each OSV must...

22 CFR 133.635 - Drug-free workplace.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Drug-free workplace. 133.635 Section 133.635 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 133.635 Drug-free workplace. Drug-free workplace means a site for the...

Attenuation coefficients of soils and some building materials of Bangladesh in the energy range 276-1332 keV

International Nuclear Information System (INIS)

Alam, M.N.; Miah, M.M.H.; Chowdhury, M.I.; Kamal, M.; Ghose, S.; Rahman, Runi

2001-01-01

The linear and mass attenuation coefficients of different types of soil, sand, building materials and heavy beach mineral samples from the Chittagong and Cox's Bazar area of Bangladesh were measured using a high-resolution HPGe detector and the γ-ray energies 276.1, 302.8, 356.0, 383.8, 661.6 and 1173.2 and 1332.5 keV emitted from point sources of 133 Ba, 137 Cs and 60 Co, respectively. The linear attenuation coefficients show a linear relationship with the corresponding densities of the samples studied. The variations of the mass attenuation coefficient with γ-ray energy were exponential in nature. The measured mass attenuation coefficient values were compared with measurements made in other countries for similar kinds of materials. The values are in good agreement with each other in most cases

CD133(+) niches and single cells in glioblastoma have different phenotypes

DEFF Research Database (Denmark)

Christensen, Karina; Schrøder, Henrik Daa; Kristensen, Bjarne Winther

2011-01-01

with CD133 and the candidate stem cell markers Sox2, Bmi-1, EGFR, podoplanin and nestin, the proliferation marker Ki67 and the endothelial cell markers CD31, CD34, and VWF. Cell counting showed that the CD133(+) cells in the niches had a significantly higher expression of Sox2, EGFR and nestin compared...

27 CFR 17.133 - Food product formulas.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Food product formulas. 17.133 Section 17.133 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... PRODUCTS Formulas and Samples Approval of Formulas § 17.133 Food product formulas. Formulas for nonbeverage...

50 CFR 14.133 - Care in transit.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Care in transit. 14.133 Section 14.133 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR TAKING..., Sea Otters, Pinnipeds, and Polar Bears) § 14.133 Care in transit. (a) Any marine mammal shall be...

23 CFR 1.33 - Conflicts of interest.

Science.gov (United States)

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Conflicts of interest. 1.33 Section 1.33 Highways... § 1.33 Conflicts of interest. No official or employee of a State or any other governmental... project shall have, directly or indirectly, any financial or other personal interest in any such contract...

Energy-range relations for hadrons in nuclear matter

Science.gov (United States)

Strugalski, Z.

1985-01-01

Range-energy relations for hadrons in nuclear matter exist similarly to the range-energy relations for charged particles in materials. When hadrons of GeV kinetic energies collide with atomic nuclei massive enough, events occur in which incident hadron is stopped completely inside the target nucleus without causing particle production - without pion production in particular. The stoppings are always accompanied by intensive emission of nucleons with kinetic energy from about 20 up to about 400 MeV. It was shown experimentally that the mean number of the emitted nucleons is a measure of the mean path in nuclear matter in nucleons on which the incident hadrons are stopped.

miR-206/133b Cluster: A Weapon against Lung Cancer?

Directory of Open Access Journals (Sweden)

Jing-Yu Pan

2017-09-01

Full Text Available Lung cancer is a deadly disease that ends numerous lives around the world. MicroRNAs (miRNAs are a group of non-coding RNAs involved in a variety of biological processes, such as cell growth, organ development, and tumorigenesis. The miR-206/133b cluster is located on the human chromosome 6p12.2, which is essential for growth and rebuilding of skeletal muscle. The miR-206/133b cluster has been verified to be dysregulated and plays a crucial role in lung cancer. miR-206 and miR-133b participate in lung tumor cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. The mechanisms are sophisticated, involving various target genes and molecular pathways, such as MET, EGFR, and the STAT3/HIF-1α/VEGF signal pathway. Hence, in this review, we summarize the role and potential mechanisms of the miR-206/133b cluster in lung cancer. Keywords: lung cancer, miR-206/133b cluster, miR-206, miR-133b

Range-energy relation, range straggling and response function of CsI(Tl), BGO and GSO(Ce) scintillators for light ions

CERN Document Server

Avdeichikov, V; Jakobsson, B; Rodin, A M; Ter-Akopian, G M

2000-01-01

Range-energy relations and range straggling of sup 1 sup , sup 2 sup , sup 3 H and sup 4 sup , sup 6 He isotopes with the energy approx 50A MeV are measured for the CsI(Tl), BGO and GSO(Ce) scintillators with an accuracy better than 0.2% and 5%, respectively. The Si-Sci/PD telescope was exposed to secondary beams from the mass separator ACCULINNA. The experimental technique is based on the registration of the 'jump' in the amplitude of the photodiode signal for ions passing through the scintillation crystal. Light response of the scintillators for ions 1<=Z<=4 is measured in energy range (5-50)A MeV, the results are in good agreement with calculations based on Birks model. The energy loss straggling for particles with DELTA E/E=0.01-0.50 and mass up to A=10 in 286 mu m DELTA E silicon detector is studied and compared with theoretical prescriptions. The results allow a precise absolute calibration of the scintillation crystal and to optimize the particle identification by the DELTA E-E(Sci/PD) method.

MicroRNA-133b inhibits hepatocellular carcinoma cell progression by targeting Sirt1

Energy Technology Data Exchange (ETDEWEB)

Tian, Zhijie [School of Biomedicine, Chengdu Medical College, Chengdu, Sichuan 610500 (China); Jiang, Hequn [The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041 (China); Liu, Ying; Huang, Yong [School of Biomedicine, Chengdu Medical College, Chengdu, Sichuan 610500 (China); Xiong, Xin [Laboratory Research Center, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016 (China); Wu, Hongwei, E-mail: hongweiwu2118@sina.com [The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610041 (China); Dai, Xiaozhen, E-mail: xiaozhendai2012@163.com [School of Biomedicine, Chengdu Medical College, Chengdu, Sichuan 610500 (China); Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, Chongqing 400044 (China); Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY (United States)

2016-05-01

MicroRNAs (miRNAs) are a class of small non-coding RNAs that function as critical gene regulators by targeting mRNAs for translational repression or degradation. In this study, we showed that the expression level of miR-133b was decreased, while Sirt1 mRNA expression levels were increased in hepatocellular carcinoma (HCC) and cell lines, and we identified Sirt1 as a novel direct target of miR-133b. The over-expression of miR-133b suppressed Sirt1 expression. In addition, miR-133b over-expression resulted in attenuating HCC cell proliferation and invasion together with apoptosis increase in vitro. HepG2 cell transplantation revealed that up-regulation of miR-133b could inhibit HCC tumor genesis in vivo. Forced expression of Sirt1 partly rescued the effect of miR-133b in vitro. Furthermore, our study showed that miR-133b over-expression or Sirt1 down-regulation elevated E-cadherin expression, and repressed glypican-3 (GPC3) and the anti-apoptotic proteins (Bcl-2, Bcl-xL, and Mcl-1) expression. The inhibition of GPC3 expression repressed Bcl-2, Bcl-xL, and Mcl-1 expression, and elevated E-cadherin expression. Moreover, the Sirt1 up-regulation resulted in increases in HCC cell proliferation and invasion together with decreases apoptosis, and increases in the cytosolic accumulation and nuclear translocation of the transcription factor β-catenin in vitro. But the effect of Sirt1 up-regulation was partly reversed by GPC3 down-regulation in vitro. Taken together, these findings provide insight into the role and mechanism of miR-133b in regulating HCC cell proliferation, invasion and apoptosis via the miR-133b/Sirt1/GPC3/Wnt β-catenin axis, and miR-133b may serve as a potential therapeutic target in HCC in the future. - Highlights: • Sirt1 is a direct target of miR-133b in HCC. • miR-133b over-expression suppresses HCC progression in vitro and in vivo. • Sirt1 restoration reverses the effect of miR-133b over-expression on HCC cells. • GPC3 down-regulation reverses

MicroRNA-133b inhibits hepatocellular carcinoma cell progression by targeting Sirt1

International Nuclear Information System (INIS)

Tian, Zhijie; Jiang, Hequn; Liu, Ying; Huang, Yong; Xiong, Xin; Wu, Hongwei; Dai, Xiaozhen

2016-01-01

MicroRNAs (miRNAs) are a class of small non-coding RNAs that function as critical gene regulators by targeting mRNAs for translational repression or degradation. In this study, we showed that the expression level of miR-133b was decreased, while Sirt1 mRNA expression levels were increased in hepatocellular carcinoma (HCC) and cell lines, and we identified Sirt1 as a novel direct target of miR-133b. The over-expression of miR-133b suppressed Sirt1 expression. In addition, miR-133b over-expression resulted in attenuating HCC cell proliferation and invasion together with apoptosis increase in vitro. HepG2 cell transplantation revealed that up-regulation of miR-133b could inhibit HCC tumor genesis in vivo. Forced expression of Sirt1 partly rescued the effect of miR-133b in vitro. Furthermore, our study showed that miR-133b over-expression or Sirt1 down-regulation elevated E-cadherin expression, and repressed glypican-3 (GPC3) and the anti-apoptotic proteins (Bcl-2, Bcl-xL, and Mcl-1) expression. The inhibition of GPC3 expression repressed Bcl-2, Bcl-xL, and Mcl-1 expression, and elevated E-cadherin expression. Moreover, the Sirt1 up-regulation resulted in increases in HCC cell proliferation and invasion together with decreases apoptosis, and increases in the cytosolic accumulation and nuclear translocation of the transcription factor β-catenin in vitro. But the effect of Sirt1 up-regulation was partly reversed by GPC3 down-regulation in vitro. Taken together, these findings provide insight into the role and mechanism of miR-133b in regulating HCC cell proliferation, invasion and apoptosis via the miR-133b/Sirt1/GPC3/Wnt β-catenin axis, and miR-133b may serve as a potential therapeutic target in HCC in the future. - Highlights: • Sirt1 is a direct target of miR-133b in HCC. • miR-133b over-expression suppresses HCC progression in vitro and in vivo. • Sirt1 restoration reverses the effect of miR-133b over-expression on HCC cells. • GPC3 down-regulation reverses

1/J2 corrections to BMN energies from the quantum long range Landau-Lifshitz model

International Nuclear Information System (INIS)

Minahan, Joseph A.; Tirziu, Alin; Tseytlin, Arkady A.

2005-01-01

In a previous paper [hep-th/0509071], it was shown that quantum 1/J corrections to the BMN spectrum in an effective Landau-Lifshitz (LL) model match with the results from the one-loop gauge theory, provided one chooses an appropriate regularization. In this paper we continue this study for the conjectured Bethe ansatz for the long range spin chain representing perturbative large-N N = 4 Super Yang-Mills in the SU(2) sector, and the 'quantum string' Bethe ansatz for its string dual. The comparison is carried out for corrections to BMN energies up to order λ-tilde 3 in the effective expansion parameter λ-tilde = λ/J 2 . After determining the 'gauge-theory' LL action to order λ-tilde 3 , which is accomplished indirectly by fixing the coefficients in the LL action so that the energies of circular strings match with the energies found using the Bethe ansatz, we find perfect agreement. We interpret this as further support for an underlying integrability of the system. We then consider the 'string-theory' LL action which is a limit of the classical string action representing fast string motion on an S 3 subspace of S 5 and compare the resulting λ-tilde 3 /J 2 corrections to the prediction of the 'string' Bethe ansatz. As in the gauge case, we find precise matching. This indicates that the LL hamiltonian supplemented with a normal ordering prescription and ζ-function regularization reproduces the full superstring result for the 1/J 2 corrections, and also signifies that the string Bethe ansatz does describe the quantum BMN string spectrum to order 1/J 2 . We also comment on using the quantum LL approach to determine the non-analytic contributions in λ that are behind the strong to weak coupling interpolation between the string and gauge results

133Xe release during post-irradiation annealing of uranium metal in the presence of a constant volume of air Pt. 1

International Nuclear Information System (INIS)

Marei, S.A.; El-Garhy, M.; El-Bayoumy, S.; Muenze, R.; Hladik, O.

1978-01-01

The fractional release of 133 Xe at different temperatures was studied as a function of time in the presence of air during post-irradiation annealing of uranium metal. The relation between the fractional release and tsup(1/2) was found to be irregular. There is an initial step in the annealing curves (at the temperature range of 400-710 deg C) which decreases by increasing temperature and totally disappears at the high temperature of 800-1000 deg C. The initial step was found to be due to the surface oxidation of uranium metal. The other two parts of the release curves are normal for 133 Xe release from uranium metal. Since in this work the irradiation temperature is low ( 133 Xe. (T.G.)

Spectroscopy of particle-phonon coupled states in $^{133}$Sb by the cluster transfer reaction of $^{132}$Sn on $^{7}$Li

CERN Multimedia

We propose to investigate, with MINIBALL coupled to T-REX, the one-valence-proton $^{133}$Sb nucleus by the cluster transfer reaction of $^{132}$Sn on $^{7}$Li. The excited $^{133}$Sb will be populated by transfer of a triton into $^{132}$Sn, followed by the emission of an $\\alpha$-particle (detected in T-REX) and 2 neutrons. The aim of the experiment is to locate states arising from the coupling of the valence proton of $^{133}$Sb to the collective low-lying phonon excitations of $^{132}$Sn (in particular the 3$^−$). According to calculations in the weak-coupling approach, these states lie in the 4$\\, - \\,$5 MeV excitation energy region and in the spin interval 1/2$\\, - \\,$ 19/2, i.e., in the region populated by the cluster transfer reaction. The results will be used to perform advanced tests of different types of nuclear interactions, usually employed in the description of particle-phonon coupled excitations. States arising from couplings of the proton with simpler core excitations, involving few nucleons...

Range-energy relations and stopping power of water, water vapour and tissue equivalent liquid for α particles over the energy range 0.5 to 8 MeV

International Nuclear Information System (INIS)

Palmer, R.B.J.; Akhavan-Rezayat, Ahmad

1978-01-01

Experimental range-energy relations are presented for alpha particles in water, water vapour and tissue equivalent liquid at energies up to 8 MeV. From these relations differential stopping powers are derived at 0.25 MeV energy intervals. Consideration is given to sources of error in the range-energy measurements and to the uncertainties that these will introduce into the stopping power values. The ratio of the differential stopping power of muscle equivalent liquid to that of water over the energy range 0.5 to 7.5 MeV is discussed in relation to the specific gravity and chemical composition of the muscle equivalent liquid. Theoretical molecular stopping power calculations based upon the Bethe formula are also presented for water. The effect of phase upon the stopping power of water is discussed. The molecular stopping power of water vapour is shown to be significantly higher than that of water for energies below 1.25 MeV and above 2.5 MeV, the ratio of the two stopping powers rising to 1.39 at 0.5 MeV and to 1.13 at 7.0 MeV. Stopping power measurements for other liquids and vapours are compared with the results for water and water vapour and some are observed to have stopping power ratios in the vapour and liquid phases which vary with energy in a similar way to water. It is suggested that there may be several factors contributing to the increased stopping power of liquids. The need for further experimental results on a wider range of liquids is stressed

Regional cerebral blood studies by the xenon-133 inhalation method in cases of cerebrovascular diseases

International Nuclear Information System (INIS)

Shimomura, Takahide

1982-01-01

rCBF was measured 428 times in 191 patients and 15 healthy volunteers by the Xenon-133 inhalation technique. The two-compartment analysis and the estimate of initial slope index were performed. There was no difference in blood flow between the two hemispheres in the 15 healthy volunteers, whose mean age was 36.5 +- 13.5 years (F 1 , right: 83.1 +- 11.4; left: 85.1 +- 12.1; 1Sl, right: 51.6 +- 6.3; left: 52.4 +- 6.0). Good correlation with a correlation coefficient of 0.965 was observed between the value obtained by the Xenon-133 inhalation and intracarotid methods in 14 patients with brain diseases. Reproducibilities of the Xenon-133 inhalation technique by serial measurement of rCBF at intervals of 30 - 40 minutes and 3 - 5 days were almost the same, with a variation coefficient of 3.7% and a correlation coefficient of 0.98. Repeated rCBF measurement by the Xenon-133 inhalation was performed during a long follow-up period of up to 1 year after bypass surgery. In 28 adult patients with occlusive cerebrovascular disease, CBF values of most patients stabilized in normal range within 3 months after the operation. In 12 patients with Moyamoya disease, CBF values were distributed over a wide range preoperatively, and increased gradually and tended to stabilize in the relatively subnormal range within 3 months after operation. This clinical experience indicates that the Xenon-133 inhalation method is a useful and safe procedure for the determination of rCBF, especially for repeated studies in cases with bypass surgery during long postoperative follow-up periods and for measurement of rCBF in child cases. (J.P.N.)

Decay /sup 133/Ba

Energy Technology Data Exchange (ETDEWEB)

Singh, K; Hasiza, M L; Grewal, B S; Sahota, H S

1982-07-01

The relative gamma ray intensities of transitions in the decay of /sup 133/Ba have been measured using an intrinsic Ge detector. The electron capture branching ratios have been determined for 81, 161, 384 and 437 keV levels. The attenuation effect of long half-life of 81 keV levels has been studied in solid and liquid media. The electron capture decay has been investigated by changing the concentration of ethylene-diamine-tetraacetic acid (EDTA) environment. The 5/2/sup +/ yields 5/2/sup +/ 79.67 keV transition has an E0 to E2 intensity qsub(k)sup(2) <= 0.31. 10 refs., 4 figures.

Experimental data on study of cosmic ray particles in the E≥2 TeV energy range at the Kosmos-1713 satellite with the Sokol-2 device

International Nuclear Information System (INIS)

Ivanenko, I.P.; Rapoport, I.D.; Shestoperov, V.Ya.

1989-01-01

Primary data of results of experiment on studying the cosmic ray particles with energy in the range exceeding 2 TeV at the Kosmos-1713 satellite using the Sokol-2 equipment are presented in the tabular form. A brief description of the equipment is given. 4 refs.; 2 figs.; 1 tab

Cerebral blood flow tomography with xenon-133

DEFF Research Database (Denmark)

Lassen, N A

1985-01-01

computed tomograph (SPECT) is required. Two brain-dedicated SPECT systems designed for this purpose are mentioned, and the method is described with special reference to the limitations inherent in the soft energy of the 133Xe primary photons. CBF tomography can be used for a multitude of clinical...... of other tracers for CBF tomography using SPECT is summarized with emphasis on the 99mTc chelates that freely pass the intact blood-brain barrier. The highly sensitive brain-dedicated SPECT systems described are a prerequisite for achieving high resolution tomograms with such tracers....

Prediction of the metabolizable energy requirements of free-range laying hens.

Science.gov (United States)

Brainer, M M A; Rabello, C B V; Santos, M J B; Lopes, C C; Ludke, J V; Silva, J H V; Lima, R A

2016-01-01

This experiment was conducted with the aim of estimating the ME requirements of free-range laying hens for maintenance, weight gain, and egg production. These experiments were performed to develop an energy requirement prediction equation by using the comparative slaughter technique and the total excreta collection method. Regression equations were used to relate the energy intake, the energy retained in the body and eggs, and the heat production of the hens. These relationships were used to determine the daily ME requirement for maintenance, the efficiency energy utilization above the requirements for maintenance, and the NE requirement for maintenance. The requirement for weight gain was estimated from the energy content of the carcass, and the diet's efficiency energy utilization was determined from the weight gain, which was measured during weekly slaughter. The requirement for egg production was estimated by considering the energy content of the eggs and the efficiency of energy deposition in the eggs. The requirement and efficiency energy utilization for maintenance were 121.8 kcal ME/(kg∙d)and 0.68, respectively. Similarly, the NE requirement for maintenance was 82.4 kcal ME/(kg∙d), and the efficiency energy utilization above maintenance was 0.61. Because the carcass body weight and energy did not increase during the trial, the weight gain could not be estimated. The requirements for egg production requirement and efficiency energy utilization for egg production were 2.48 kcal/g and 0.61, respectively. The following energy prediction equation for free-range laying hens (without weight gain) was developed: ME /(hen ∙ d) = 121.8 × W + 2.48 × EM, in which W = body weight (kg) and EM = egg mass (g/[hen ∙ d]).

Physics of ep collisions in the TeV energy range

International Nuclear Information System (INIS)

Altarelli, G.; Mele, B.; Rueckl, R.

1984-01-01

We study the physics of electron-proton collisions in the range of centre-of-mass energies between √s approx.= 0.3 TeV (HERA) and √s approx.= (1-2) TeV. The latter energies would be achieved if the electron or positron beam of LEP [Esub(e) approx.= (50-100) GeV] is made to collide with the proton beam of LHC [Esub(p) approx.= (5-10) TeV]. (orig.)

Single-Particle States in $^{133}$Sn

CERN Multimedia

Huck, A

2002-01-01

% IS338 \\\\ \\\\ It is suggested to investigate the $\\beta^- $-decay of $^{133}$In and $^{134}$In in order to determine the single-particle states in $^{133}$Sn, which are so far unknown and needed for the shell-model description of the region close to $^{132}$Sn. Large hyper-pure Ge-detectors will be used for the $\\gamma$-ray spectroscopy. In the experiments with $^{134}$In, delayed neutrons in coincidence with $\\gamma$-rays from excited states in $^{133}$Sn provide the opportunity for a very selective detection of the states in question.

Emission probability determination of {sup 133}Ba by the sum-peak method

Energy Technology Data Exchange (ETDEWEB)

Silva, R.L. da; Almeida, M.C.M. de; Delgado, J.U.; Poledna, R.; Araujo, M.T.F.; Trindade, O.L.; Veras, E.V. de; Santos, A.; Rangel, J.; Ferreira Filho, A.L., E-mail: ronaldo@ird.gov.br, E-mail: marcandida@yahoo.com.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

2016-07-01

The National Laboratory of Metrology Ionizing Radiation (LNMRI/IRD/CNEN) has several measurement methods in order to ensure low uncertainties about the results. Through gamma spectrometry analysis by sum-peak absolute method they were performed the standardization of {sup 133}Ba activity and your emission probability determination of different energies with reduced uncertainties. The advantages of radionuclides calibrations by absolute method are accuracy, low uncertainties and is not necessary the use of radionuclides reference standards. {sup 133}Ba is used in research laboratories on calibration detectors in different work areas. The uncertainties for the activity and for the emission probability results are lower than 1%. (author)

21 CFR 133.178 - Pasteurized neufchatel cheese spread with other foods.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Pasteurized neufchatel cheese spread with other foods. 133.178 Section 133.178 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... karaya, gum tragacanth, carob bean gum, gelatin, algin (sodium alginate), propylene glycol alginate, guar...

hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors.

Directory of Open Access Journals (Sweden)

Shunsuke Ohnishi

Full Text Available CD133 is a cellular surface protein that has been reported to be a cancer stem cell marker, and thus it is considered to be a potential target for cancer treatment. However, the mechanism regulating CD133 expression is not yet understood. In this study, we analyzed the activity of five putative promoters (P1-P5 of CD133 in human embryonic kidney (HEK 293 cells and colon cancer cell line WiDr, and found that the activity of promoters, particularly of P5, is elevated by overexpression of hypoxia-inducible factors (HIF-1α and HIF-2α. Deletion and mutation analysis identified one of the two E-twenty six (ETS binding sites (EBSs in the P5 region as being essential for its promoter activity induced by HIF-1α and HIF-2α. In addition, a chromatin imunoprecipitation assay demonstrated that HIF-1α and HIF-2α bind to the proximal P5 promoter at the EBSs. The immunoprecipitation assay showed that HIF-1α physically interacts with Elk1; however, HIF-2α did not bind to Elk1 or ETS1. Furthermore, knockdown of both HIF-1α and HIF-2α resulted in a reduction of CD133 expression in WiDr. Taken together, our results revealed that HIF-1α and HIF-2α activate CD133 promoter through ETS proteins.

Kilovoltage energy imaging with a radiotherapy linac with a continuously variable energy range.

Science.gov (United States)

Roberts, D A; Hansen, V N; Thompson, M G; Poludniowski, G; Niven, A; Seco, J; Evans, P M

2012-03-01

In this paper, the effect on image quality of significantly reducing the primary electron energy of a radiotherapy accelerator is investigated using a novel waveguide test piece. The waveguide contains a novel variable coupling device (rotovane), allowing for a wide continuously variable energy range of between 1.4 and 9 MeV suitable for both imaging and therapy. Imaging at linac accelerating potentials close to 1 MV was investigated experimentally and via Monte Carlo simulations. An imaging beam line was designed, and planar and cone beam computed tomography images were obtained to enable qualitative and quantitative comparisons with kilovoltage and megavoltage imaging systems. The imaging beam had an electron energy of 1.4 MeV, which was incident on a water cooled electron window consisting of stainless steel, a 5 mm carbon electron absorber and 2.5 mm aluminium filtration. Images were acquired with an amorphous silicon detector sensitive to diagnostic x-ray energies. The x-ray beam had an average energy of 220 keV and half value layer of 5.9 mm of copper. Cone beam CT images with the same contrast to noise ratio as a gantry mounted kilovoltage imaging system were obtained with doses as low as 2 cGy. This dose is equivalent to a single 6 MV portal image. While 12 times higher than a 100 kVp CBCT system (Elekta XVI), this dose is 140 times lower than a 6 MV cone beam imaging system and 6 times lower than previously published LowZ imaging beams operating at higher (4-5 MeV) energies. The novel coupling device provides for a wide range of electron energies that are suitable for kilovoltage quality imaging and therapy. The imaging system provides high contrast images from the therapy portal at low dose, approaching that of gantry mounted kilovoltage x-ray systems. Additionally, the system provides low dose imaging directly from the therapy portal, potentially allowing for target tracking during radiotherapy treatment. There is the scope with such a tuneable system

CD133 expression in well-differentiated pancreatic neuroendocrine tumors: a potential predictor of progressive clinical courses.

Science.gov (United States)

Sakai, Yasuhiro; Hong, Seung-Mo; An, Soyeon; Kim, Joo Young; Corbeil, Denis; Karbanová, Jana; Otani, Kyoko; Fujikura, Kohei; Song, Ki-Byung; Kim, Song Cheol; Akita, Masayuki; Nanno, Yoshihide; Toyama, Hirochika; Fukumoto, Takumi; Ku, Yonson; Hirose, Takanori; Itoh, Tomoo; Zen, Yoh

2017-03-01

The present study aimed to elucidate whether the stemness molecule, CD133, is expressed in well-differentiated pancreatic neuroendocrine tumors (PanNETs; World Health Organization grades 1 and 2) and establish its clinical relevance using 2 separate cohorts. In the first series (n = 178) in which tissue microarrays were available, immunohistochemistry revealed that CD133 was expressed in 14 cases (8%). CD133+ PanNETs had higher TNM stages (P < .01), more frequent lymphovascular invasion (P = .01), and higher recurrence rates (P = .01). In the second cohort (n = 56), the expression of CD133 and CK19 was examined in whole tissue sections. CD133 and CK19 were positive in 10 (18%) and 36 (64%) cases, respectively. CD133 expression correlated with higher pT scores (P < .01), the presence of microscopic venous infiltration (P = .03), and shorter disease-free periods (P < .01). When cases were divided into grade 1 and 2 neoplasms, patients with CD133+ PanNET continued to have shorter disease-free periods than did those with CD133- tumors in both groups (P < .01 and P = .02, respectively). Although CK19+ cases had shorter disease-free periods than did CK19- cases in the whole cohort (P = .02), this difference was less apparent in subanalyses of grade 1 and 2 cases. CD133 expression also appeared to be an independent predictive factor for tumor recurrence in a multivariate analysis (P = .018). The CD133 phenotype was identical between primary and metastatic foci in 17 of 18 cases from which tissues of metastatic deposits were available. In conclusion, the combination of CD133 phenotyping and World Health Organization grading may assist in stratifying patients in terms of the risk of progressive clinical courses. Copyright © 2016 Elsevier Inc. All rights reserved.

46 CFR 133.03 - Relationship to international standards.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Relationship to international standards. 133.03 Section 133.03 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS General § 133.03 Relationship to international standards. This subpart and subpart B of...

Expression and Significance of Stem Cell Markers CK19, Notch3, CD133, P75NTR, STRO-1 and ABCG2 in Pulmonary Squamous Carcinomas

Directory of Open Access Journals (Sweden)

Xuyong LIN, , , , ,

2009-04-01

Full Text Available Background and objective Increasing reports showed that some tumor stem cells were selfrenewal and multi-lineage differentiated in tumors, similar to the normal stem cells in human body. The aim of this study is to observe the expression of stem cell markers in lung squamous carcinoma tissues. Methods Fifty-four lung cancer specimens from surgery were analyzed for CK19, Notch3, CD133, P75NTR, STRO-1 and ABCG2 expression by using S-P immunohistochemistry. In addition, ten normal lung tissue samples were included as control. Results CK19, Notch3, CD133 and ABCG2 were expressed in 54 Lung cancer tissues, without expression of P75NTR and STRO-1. The expressionrate of CK19, Notch3, CD133 and ABCG2 was 66.67% (36/54, 87.04% (47/54, 50% (27/54, and 61.11% (33/54 respectively. The levels of expression of Notch3, CD133 and ABCG2 were significantly lower in high differentiation group than those in moderate and low differentiation group (P <0.05. The levels of expression of CK19, CD133 and ABCG2 were significantly higher in lymph node metastasis group than those in non-metastasis group (P <0.05. The percentage of total positive cells of four stem cell markers in serial tissue sections was lower than 2%. Conclusion There was expression ofsome stem cell markers in pulmonary squamous carcinomas, and there was relationship between expression degree withdifferentiation degree and lymph node metastasis.

40 CFR 133.102 - Secondary treatment.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Secondary treatment. 133.102 Section... TREATMENT REGULATION § 133.102 Secondary treatment. The following paragraphs describe the minimum level of effluent quality attainable by secondary treatment in terms of the parameters—BOD5, SS and pH. All...

Range-separated density-functional theory for molecular excitation energies

International Nuclear Information System (INIS)

Rebolini, E.

2014-01-01

Linear-response time-dependent density-functional theory (TDDFT) is nowadays a method of choice to compute molecular excitation energies. However, within the usual adiabatic semi-local approximations, it is not able to describe properly Rydberg, charge-transfer or multiple excitations. Range separation of the electronic interaction allows one to mix rigorously density-functional methods at short range and wave function or Green's function methods at long range. When applied to the exchange functional, it already corrects most of these deficiencies but multiple excitations remain absent as they need a frequency-dependent kernel. In this thesis, the effects of range separation are first assessed on the excitation energies of a partially-interacting system in an analytic and numerical study in order to provide guidelines for future developments of range-separated methods for excitation energy calculations. It is then applied on the exchange and correlation TDDFT kernels in a single-determinant approximation in which the long-range part of the correlation kernel vanishes. A long-range frequency-dependent second-order correlation kernel is then derived from the Bethe-Salpeter equation and added perturbatively to the range-separated TDDFT kernel in order to take into account the effects of double excitations. (author)

Energy Impacts of Effective Range Hood Use for all U.S. Residential Cooking

Energy Technology Data Exchange (ETDEWEB)

Logue, Jennifer M; Singer, Brett

2014-06-01

Range hood use during residential cooking is essential to maintaining good indoor air quality. However, widespread use will impact the energy demand of the U.S. housing stock. This paper describes a modeling study to determine site energy, source energy, and consumer costs for comprehensive range hood use. To estimate the energy impacts for all 113 million homes in the U.S., we extrapolated from the simulation of a representative weighted sample of 50,000 virtual homes developed from the 2009 Residential Energy Consumption Survey database. A physics-based simulation model that considered fan energy, energy to condition additional incoming air, and the effect on home heating and cooling due to exhausting the heat from cooking was applied to each home. Hoods performing at a level common to hoods currently in U.S. homes would require 19?33 TWh [69?120 PJ] of site energy, 31?53 TWh [110-190 PJ] of source energy; and would cost consumers $1.2?2.1 billion (U.S.$2010) annually in the U.S. housing stock. The average household would spend less than $15 annually. Reducing required airflow, e.g. with designs that promote better pollutant capture has more energy saving potential, on average, than improving fan efficiency.

46 CFR 133.130 - Stowage of survival craft.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Stowage of survival craft. 133.130 Section 133.130... SYSTEMS Requirements for All OSVs § 133.130 Stowage of survival craft. (a) General. Each survival craft must be stowed as follows: (1) Each survival craft must be as close to the accommodation and service...

41 CFR 105-71.133 - Supplies.

Science.gov (United States)

2010-07-01

... aggregate fair market value upon termination or completion of the award, and if the supplies are not needed... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Supplies. 105-71.133...-Award Requirements/Changes, Property, and Subawards § 105-71.133 Supplies. (a) Title. Title to supplies...

Cosmic ray antiproton measurements in the 4-19 GeV energy range using the NMSU/WiZard-matter antimatter superconducting spectrometer 2 (MASS2)

Energy Technology Data Exchange (ETDEWEB)

Basini, G.; Bongiorno, F. [INFN, Laboratori Nazionali di Frascati, Rome (Italy); Brunetti, M.T.; Codini, A.; Grimani, C. [Perugia Univ. (Italy)]|[INFN, Perugia (Italy); De Pascale, M.P. [Rome Univ. `Tor Vergata` (Italy)]|[INFN, Rome (Italy); Hof, M. [Siegen Univ. (Germany). Fachbereich Physik; Golden, R.L.; Stochaj, S.J. [New Mexico State Univ., Las Cruces, NM (United States). Particle Astrophysics Lab.; Brancaccio, F.M. [Florence Univ. (Italy)]|[INFN, Florence (Italy)

1995-09-01

The p/p-ratio from 4 to 19 GeV has been measured using the NMSU/WiZard balloon borne matter antimatter superconducting spectrometer (MASS2) instrument. This is the first confirmation of the cosmic ray antiproton component made in this energy range since their discovery in 1979. The MASS2 instrument is an updated version of the instrument flown in 1979. The p/p- ratio is 1.52x10{sup -}4.

{sup 65}Zn and {sup 133}Ba standardizing by photon-photon coincidence counting

Energy Technology Data Exchange (ETDEWEB)

Loureiro, Jamir S.; Cruz, Paulo A.L. da; Iwahara, Akira; Delgado, José U., E-mail: palcruz@ird.gov.br [Instituto de Radioproteção e Dosimetria (LNMRI/IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Lab. Nacional de Metrologia das Radiações Ionizantes; Lopes, Ricardo T. [Coordenacao de Pos-Graduacao e Pesquisa de Engenharia (PEN/COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear

2017-07-01

The LNMRI/Brazil has deployed a system using X-gamma coincidence technique for the standardizing radionuclide, which present simple and complex decay scheme with X-rays of energy below 100 keV. The work was carried on radionuclide metrology laboratory using a sodium iodide detector, for gamma photons, in combination with a high purity germanium detector for X-rays. Samples of {sup 65}Zn and {sup 133}Ba were standardized and the results for both radionuclides showed good precision and accuracy when compared with reference values. The standardization differences were 0.72 % for {sup 65}Zn and 0.48 % for {sup 133}Ba samples. (author)

33 CFR 133.9 - Requests: Where made.

Science.gov (United States)

2010-07-01

...) MARINE POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL LIABILITY TRUST FUND; STATE ACCESS § 133.9 Requests: Where made. Requests for access to the Fund under § 133.5 must be made by telephone or...

Increased expression of CD133 and reduced dystroglycan expression are strong predictors of poor outcome in colon cancer patients

Directory of Open Access Journals (Sweden)

Coco Claudio

2012-09-01

Full Text Available Abstract Background Expression levels of CD133, a cancer stem cell marker, and of the α-subunit of the dystroglycan (α-DG complex, have been previously reported to be altered in colorectal cancers. Methods Expression levels of CD133 and α-DG were assessed by immunohistochemistry in a series of colon cancers and their prognostic significance was evaluated. Results Scattered cells positive for CD133 were rarely detected at the bases of the crypts in normal colonic mucosa while in cancer cells the median percentage of positive cells was 5% (range 0–80. A significant correlation was observed with pT parameter and tumor stage but not with tumor grade and N status. Recurrence and death from disease were significantly more frequent in CD133-high expressing tumors and Kaplan-Meier curves showed a significant separation between high vs low expressor groups for both disease-free (p = 0.002 and overall (p = 0.008 survival. Expression of α-DG was reduced in a significant fraction of tumors but low α-DG staining did not correlate with any of the classical clinical-pathological parameters. Recurrence and death from the disease were significantly more frequent in α-DG-low expressing tumors and Kaplan-Meier curves showed a significant separation between high vs low expressor tumors for both disease-free (p = 0.02 and overall (p = 0.02 survival. Increased expression of CD133, but not loss of α-DG, confirmed to be an independent prognostic parameters at a multivariate analysis associated with an increased risk of recurrence (RR = 2.4; p = 0.002 and death (RR = 2.3; p = 0.003. Conclusions Loss of α-DG and increased CD133 expression are frequent events in human colon cancer and evaluation of CD133 expression could help to identify high-risk colon cancer patients.

12 CFR 13.3 - Business conduct.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Business conduct. 13.3 Section 13.3 Banks and....3 Business conduct. A bank that is a government securities broker or dealer shall observe high standards of commercial honor and just and equitable principles of trade in the conduct of its business as a...

Infrared Absorption Spectra, Radiative Efficiencies, and Global Warming Potentials of Newly-Detected Halogenated Compounds: CFC-113a, CFC-112 and HCFC-133a

Directory of Open Access Journals (Sweden)

Maryam Etminan

2014-07-01

Full Text Available CFC-113a (CF3CCl3, CFC-112 (CFCl2CFCl2 and HCFC-133a (CF3CH2Cl are three newly detected molecules in the atmosphere that are almost certainly emitted as a result of human activity. It is important to characterise the possible contribution of these gases to radiative forcing of climate change and also to provide information on the CO2-equivalence of their emissions. We report new laboratory measurements of absorption cross-sections of these three compounds at a resolution of 0.01 cm−1 for two temperatures 250 K and 295 K in the spectral range of 600–1730 cm−1. These spectra are then used to calculate the radiative efficiencies and global warming potentials (GWP. The radiative efficiencies are found to be between 0.15 and 0.3 W∙m−2∙ppbv−1. The GWP for a 100 year time horizon, relative to carbon dioxide, ranges from 340 for the relatively short-lived HCFC-133a to 3840 for the longer-lived CFC-112. At current (2012 concentrations, these gases make a trivial contribution to total radiative forcing; however, the concentrations of CFC-113a and HCFC-133a are continuing to increase. The 2012 CO2-equivalent emissions, using the GWP (100, are estimated to be about 4% of the current global CO2-equivalent emissions of HFC-134a.

Impact of CD133 positive stem cell proportion on survival in patients with glioblastoma multiforme

International Nuclear Information System (INIS)

Kase, Marju; Minajeva, Ave; Niinepuu, Kristi; Kase, Sandra; Vardja, Markus; Asser, Toomas; Jaal, Jana

2013-01-01

The aim of the study was to assess the impact of CD133-positive (CD133+) cancer stem cell proportions on treatment results of glioblastoma multiforme (GBM) patients. Patients with GBM (n = 42) received postoperative radiotherapy (± chemotherapy). Surgically excised GBM tissue sections were immunohistochemically examined for CD133 expression. The proportions of CD133+ GBM cells were determined (%). The proportion of CD133+ GBM stem cells was established by 2 independent researchers whose results were in good accordance (R = 0.8, p < 0.01). Additionally, CD133 expression levels were correlated with patients overall survival. The proportion of CD133+ cells varied between patients, being from 0.5% to 82%. Mean and median proportions of CD133+ cells of the entire study group were 33% ± 24% (mean ± SD) and 28%, respectively. Clinical data do not support the association between higher proportion of stem cells and the aggressiveness of GBM. Median survival time of the study group was 10.0 months (95% CI 9.0–11.0). The survival time clearly depended on the proportion of CD133+ cells (log rank test, p = 0.02). Median survival times for patients with low (< median) and high (≥ median) proportion of CD133+ cells were 9.0 months (95% CI 7.6–10.5) and 12.0 months (95% CI 9.3–14.7), respectively. In multivariate analysis, the proportion of CD133+ cells emerged as a significant independent predictor for longer overall survival (HR 2.0, 95% CI 1.0–3.8, p = 0.04). In patients with higher stem cell proportion, significantly longer survival times after postoperative radiotherapy were achieved. Underlying reasons and possible higher sensitivity of GBM stem cells to fractionated radio-therapy should be clarified in further studies

CD133-expressing thyroid cancer cells are undifferentiated, radioresistant and survive radioiodide therapy

International Nuclear Information System (INIS)

Ke, Chien-Chih; Liu, Ren-Shyan; Yang, An-Hang; Liu, Ching-Sheng; Chi, Chin-Wen; Tseng, Ling-Ming; Tsai, Yi-Fan; Ho, Jennifer H.; Lee, Chen-Hsen; Lee, Oscar K.

2013-01-01

131 I therapy is regularly used following surgery as a part of thyroid cancer management. Despite an overall relatively good prognosis, recurrent or metastatic thyroid cancer is not rare. CD133-expressing cells have been shown to mark thyroid cancer stem cells that possess the characteristics of stem cells and have the ability to initiate tumours. However, no studies have addressed the influence of CD133-expressing cells on radioiodide therapy of the thyroid cancer. The aim of this study was to investigate whether CD133 + cells contribute to the radioresistance of thyroid cancer and thus potentiate future recurrence and metastasis. Thyroid cancer cell lines were analysed for CD133 expression, radiosensitivity and gene expression. The anaplastic thyroid cancer cell line ARO showed a higher percentage of CD133 + cells and higher radioresistance. After γ-irradiation of the cells, the CD133 + population was enriched due to the higher apoptotic rate of CD133 - cells. In vivo 131 I treatment of ARO tumour resulted in an elevated expression of CD133, Oct4, Nanog, Lin28 and Glut1 genes. After isolation, CD133 + cells exhibited higher radioresistance and higher expression of Oct4, Nanog, Sox2, Lin28 and Glut1 in the cell line or primarily cultured papillary thyroid cancer cells, and lower expression of various thyroid-specific genes, namely NIS, Tg, TPO, TSHR, TTF1 and Pax8. This study demonstrates the existence of CD133-expressing thyroid cancer cells which show a higher radioresistance and are in an undifferentiated status. These cells possess a greater potential to survive radiotherapy and may contribute to the recurrence of thyroid cancer. A future therapeutic approach for radioresistant thyroid cancer may focus on the selective eradication of CD133 + cells. (orig.)

Improved energy of the 21.5 keV M1+E2 nuclear transition in Eu-151

Czech Academy of Sciences Publication Activity Database

Inoyatov, A. K.; Kovalík, Alojz; Filosofov, D. V.; Ryšavý, Miloš; Perevoshchikov, L. L.; Baimukhanova, A.

2016-01-01

Roč. 52, č. 5 (2016), s. 133 ISSN 1434-6001 R&D Projects: GA ČR(CZ) GAP203/12/1896; GA MŠk LG14004 Institutional support: RVO:61389005 Keywords : electron binding energies * internal conversion * Gd-151 Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 2.833, year: 2016

Properties of short-range and long-range correlation energy density functionals from electron-electron coalescence

International Nuclear Information System (INIS)

Gori-Giorgi, Paola; Savin, Andreas

2006-01-01

The combination of density-functional theory with other approaches to the many-electron problem through the separation of the electron-electron interaction into a short-range and a long-range contribution is a promising method, which is raising more and more interest in recent years. In this work some properties of the corresponding correlation energy functionals are derived by studying the electron-electron coalescence condition for a modified (long-range-only) interaction. A general relation for the on-top (zero electron-electron distance) pair density is derived, and its usefulness is discussed with some examples. For the special case of the uniform electron gas, a simple parametrization of the on-top pair density for a long-range only interaction is presented and supported by calculations within the ''extended Overhauser model.'' The results of this work can be used to build self-interaction corrected short-range correlation energy functionals

Low-energy modes and medium-range correlated motions in Pd79Ge21 alloy glass

International Nuclear Information System (INIS)

Shibata, Kaoru; Mizuseki, Hiroshi; Suzuki, Kenji

1993-01-01

It is well known that there are excess modes over the sound wave in low energy region below about 10 meV in glass materials, which do not exist in corresponding crystalline materials. We examined the low energy modes in a Pd 79 Ge 21 alloys glass by means of inelastic neutron scattering. Measurements were performed on the crystal analyzer type time-of-flight spectrometer LAM-40 with PG(002) and Ge(311) analyzer mirror, which is installed at KENS. The dynamic structure factor S(Q,ω) was obtained over the wide momentum range from 0.5 to 5.2A -1 . The measured S(Q,ω)'s have almost same momentum (Q) dependence at each energy (ℎω) in the energy range from 2.0 to 8.0 meV. In the energy region below 3 meV, we found a small shoulder peak at Q = 1.7A -1 in the momentum dependence of S(Q,ω). It corresponds to a prepeak in S(Q). Therefore it is concluded that the low energy modes in Pd 79 Ge 21 alloy glass is mainly contributed from medium-range correlated motions in the cluster consisting of a few chemical short-range structure units of Pd 6 Ge trigonal prism. (author)

Transcatheter Arterial Infusion of Autologous CD133+ Cells for Diabetic Peripheral Artery Disease

Directory of Open Access Journals (Sweden)

Xiaoping Zhang

2016-01-01

Full Text Available Microvascular lesion in diabetic peripheral arterial disease (PAD still cannot be resolved by current surgical and interventional technique. Endothelial cells have the therapeutic potential to cure microvascular lesion. To evaluate the efficacy and immune-regulatory impact of intra-arterial infusion of autologous CD133+ cells, we recruited 53 patients with diabetic PAD (27 of CD133+ group and 26 of control group. CD133+ cells enriched from patients’ PB-MNCs were reinfused intra-arterially. The ulcer healing followed up till 18 months was 100% (3/3 in CD133+ group and 60% (3/5 in control group. The amputation rate was 0 (0/27 in CD133+ group and 11.54% (3/26 in control group. Compared with the control group, TcPO2 and ABI showed obvious improvement at 18 months and significant increasing VEGF and decreasing IL-6 level in the CD133+ group within 4 weeks. A reducing trend of proangiogenesis and anti-inflammatory regulation function at 4 weeks after the cells infusion was also found. These results indicated that autologous CD133+ cell treatment can effectively improve the perfusion of morbid limb and exert proangiogenesis and anti-inflammatory immune-regulatory impacts by paracrine on tissue microenvironment. The CD133+ progenitor cell therapy may be repeated at a fixed interval according to cell life span and immune-regulatory function.

40 CFR 133.105 - Treatment equivalent to secondary treatment.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Treatment equivalent to secondary treatment. 133.105 Section 133.105 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS SECONDARY TREATMENT REGULATION § 133.105 Treatment equivalent to secondary treatment...

Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders

DEFF Research Database (Denmark)

Isles, Anthony R; Ingason, Andrés; Lowther, Chelsea

2016-01-01

Duplications at 15q11.2-q13.3 overlapping the Prader-Willi/Angelman syndrome (PWS/AS) region have been associated with developmental delay (DD), autism spectrum disorder (ASD) and schizophrenia (SZ). Due to presence of imprinted genes within the region, the parental origin of these duplications m...

Electron-impact rotationally elastic total cross sections for H2CO and HCOOH over a wide range of incident energy (0.01-2000 eV)

International Nuclear Information System (INIS)

Vinodkumar, Minaxi; Bhutadia, Harshad; Antony, Bobby; Mason, Nigel

2011-01-01

This paper reports computational results of the total cross sections for electron impact on H 2 CO and HCOOH over a wide range of electron impact energies from 0.01 eV to 2 keV. The total cross section is presented as sum of the elastic and electronic excitation cross sections for incident energies. The calculation uses two different methodologies, below the ionization threshold of the target the cross section is calculated using the UK molecular R-matrix code through the Quantemol-N software package while cross sections at higher energies are evaluated using the spherical complex optical potential formalism. The two methods are found to be consistent at the transition energy (∼15 eV). The present results are, in general, found to be in good agreement with previous experimental and theoretical results (wherever available) and, thus, the present results can serve as a benchmark for the cross section over a wide range of energy.

CD133 and BMI1 expressions and its prognostic role in primary ...

Indian Academy of Sciences (India)

This study aimed to analyse the expression of CD133 mRNA and its correlations ... CD133 mRNA and BMI1 protein expression could independently predict the glioblastoma .... treatment at the National Institute of Mental Health and Neu- .... Low. 16 (76.2). High. 53 mutations of which 38 were exonic and 15 were intronic.

Daily energy expenditure in free-ranging Gopher Tortoises (Gopherus polyphemus)

Science.gov (United States)

Jodice, P.G.R.; Epperson, D.M.; Visser, G. Henk

2006-01-01

Studies of ecological energetics in chelonians are rare. Here, we report the first measurements of daily energy expenditure (DEE) and water influx rates (WIRs) in free-ranging adult Gopher Tortoises (Gopherus polyphemus). We used the doubly labeled water (DLW) method to measure DEE in six adult tortoises during the non-breeding season in south-central Mississippi, USA. Tortoise DEE ranged from 76.7-187.5 kj/day and WIR ranged from 30.6-93.1 ml H2O/day. Daily energy expenditure did not differ between the sexes, but DEE was positively related to body mass. Water influx rates varied with the interaction of sex and body mass. We used a log/log regression model to assess the allometric relationship between DEE and body mass for Gopher Tortoises, Desert Tortoises (Gopherus agassizii), and Box Turtles (Terrapene carolina), the only chelonians for which DEE has been measured. The slope of this allometric model (0.626) was less than that previously calculated for herbivorous reptiles (0.813), suggesting that chelonians may expend energy at a slower rate per unit of body mass compared to other herbivorous reptiles. We used retrospective power analyses and data from the DLW isotope analyses to develop guidelines for sample sizes and duration of measurement intervals, respectively, for larger-scale energetic studies in this species. ?? 2006 by the American Society of Ichthyologists and Herpetologists.

CD133 (Prominin negative human neural stem cells are clonogenic and tripotent.

Directory of Open Access Journals (Sweden)

Yirui Sun

Full Text Available CD133 (Prominin is widely used as a marker for the identification and isolation of neural precursor cells from normal brain or tumor tissue. However, the assumption that CD133 is expressed constitutively in neural precursor cells has not been examined.In this study, we demonstrate that CD133 and a second marker CD15 are expressed heterogeneously in uniformly undifferentiated human neural stem (NS cell cultures. After fractionation by flow cytometry, clonogenic tripotent cells are found in populations negative or positive for either marker. We further show that CD133 is down-regulated at the mRNA level in cells lacking CD133 immunoreactivity. Cell cycle profiling reveals that CD133 negative cells largely reside in G1/G0, while CD133 positive cells are predominantly in S, G2, or M phase. A similar pattern is apparent in mouse NS cell lines. Compared to mouse NS cells, however, human NS cell cultures harbour an increased proportion of CD133 negative cells and display a longer doubling time. This may in part reflect a sub-population of slow- or non-cycling cells amongst human NS cells because we find that around 5% of cells do not take up BrdU over a 14-day labelling period. Non-proliferating NS cells remain undifferentiated and at least some of them are capable of re-entry into the cell cycle and subsequent continuous expansion.The finding that a significant fraction of clonogenic neural stem cells lack the established markers CD133 and CD15, and that some of these cells may be dormant or slow-cycling, has implications for approaches to identify and isolate neural stem cells and brain cancer stem cells. Our data also suggest the possibility that CD133 may be specifically down-regulated during G0/G1, and this should be considered when this marker is used to identify and isolate other tissue and cancer stem cells.

Long-range outlook of energy demands and supplies

International Nuclear Information System (INIS)

1984-01-01

An interim report on the long-range outlook of energy demands and supplies in Japan as prepared by an ad hoc committee, Advisory Committee for Energy was given for the period up to the year 2000. As the energy demands in terms of crude oil, the following figures are set: 460 million kl for 1990, 530 million kl for 1995, and 600 million kl for 2000. In Japan, without domestic energy resources, over 80% of the primary energy has been imported; the reliance on Middle East where political situation is unstable, for petroleum is very large. The following things are described. Background and policy; energy demands in industries, transports, and people's livelihood; energy supplies by coal, nuclear energy, petroleum, etc.; energy demand/supply outlook for 2000. (Mori, K.)

19 CFR 133.26 - Demand for redelivery of released merchandise.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Demand for redelivery of released merchandise. 133... Recorded Trademarks or Recorded Trade Names § 133.26 Demand for redelivery of released merchandise. If it... restrictions of § 133.22 or § 133.23 of this subpart, the port director shall promptly make demand for the...

The partition coefficients of 133Xe between blood and bone

International Nuclear Information System (INIS)

Lahtinen, T.; Karjalainen, P.; Vaeaenaenen, A.; Lahtinen, R.; Alhava, E.M.

1981-01-01

The partition coefficients of 133 Xe between blood and haematopoietic bone marrow and homogenised bone have been determined in vitro. The partition coefficient lambda 1 corresponding to haematopoietic marrow was 0.95 ml g -1 while that corresponding to homogenised bone was a function of age, lambda 2 = 3.11 + 0.049(age)(ml g -1 ). These data can be used for calculating regional blood flow in healthy human femur by means of a simple 133 Xe radionuclide method. (author)

Establishment of CMab-43, a Sensitive and Specific Anti-CD133 Monoclonal Antibody, for Immunohistochemistry.

Science.gov (United States)

Itai, Shunsuke; Fujii, Yuki; Nakamura, Takuro; Chang, Yao-Wen; Yanaka, Miyuki; Saidoh, Noriko; Handa, Saori; Suzuki, Hiroyoshi; Harada, Hiroyuki; Yamada, Shinji; Kaneko, Mika K; Kato, Yukinari

2017-10-01

CD133, also known as prominin-1, was first described as a cell surface marker on early progenitor and hematopoietic stem cells. It is a five-domain transmembrane protein composed of an N-terminal extracellular tail, two small cytoplasmic loops, two large extracellular loops containing seven potential glycosylation sites, and a short C-terminal intracellular tail. CD133 has been used as a marker to identify cancer stem cells derived from primary solid tumors and as a prognostic marker of gliomas. Herein, we developed novel anti-CD133 monoclonal antibodies (mAbs) and characterized their efficacy in flow cytometry, Western blot, and immunohistochemical analyses. We expressed the full length of CD133 in LN229 glioblastoma cells, immunized mice with LN229/CD133 cells, and performed the first screening using flow cytometry. After limiting dilution, we established 100 anti-CD133 mAbs, reacting with LN229/CD133 cells but not with LN229 cells. Subsequently, we performed the second and third screening with Western blot and immunohistochemical analyses, respectively. Among 100 mAbs, 11 strongly reacted with CD133 in Western blot analysis. One of 11 clones, CMab-43 (IgG 2a , kappa), showed a sensitive and specific reaction against colon cancer cells, warranting the use of CMab-43 in detecting CD133 in pathological analyses of CD133-expressing cancers.

Interpretation of cosmic ray spectrum above the knee measured by the Tunka-133 array

Energy Technology Data Exchange (ETDEWEB)

Sveshnikova, Lyubov, E-mail: tfl10@mail.ru [Skobeltsyn Institute of Nuclear Physics MSU, Leninskie Gory GSP 1, Moscow 119992 (Russian Federation); Kuzmichev, Leonid; Korosteleva, Elena; Prosin, Vasiliy [Skobeltsyn Institute of Nuclear Physics MSU, Leninskie Gory GSP 1, Moscow 119992 (Russian Federation); Ptuskin, V.S. [Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propogation (IZMIRAN), Russian Academy of Sciences, Troitsk, Moscow region 142092 (Russian Federation)

2014-11-15

A probable interpretation of the fine structure of all particle energy spectrum between the knee and the ankle (the sharp first knee at 3–4 PeV, the spectrum hardening at 20–30 PeV, the second knee at 200–300 PeV) as well as a (E) dependence measured recently by the Tunka-133 experiment, is presented. We show that these features are compatible with the combined model where cosmic rays around the knee are produced by the group of dedicated sources and the extragalactic light component appears in the energy region of 10{sup 16}–10{sup 17} eV and reaches about 50% of all particles around (2–3)×10{sup 17} eV.

Long-range energy transfer in self-assembled quantum dot-DNA cascades

Science.gov (United States)

Goodman, Samuel M.; Siu, Albert; Singh, Vivek; Nagpal, Prashant

2015-11-01

The size-dependent energy bandgaps of semiconductor nanocrystals or quantum dots (QDs) can be utilized in converting broadband incident radiation efficiently into electric current by cascade energy transfer (ET) between layers of different sized quantum dots, followed by charge dissociation and transport in the bottom layer. Self-assembling such cascade structures with angstrom-scale spatial precision is important for building realistic devices, and DNA-based QD self-assembly can provide an important alternative. Here we show long-range Dexter energy transfer in QD-DNA self-assembled single constructs and ensemble devices. Using photoluminescence, scanning tunneling spectroscopy, current-sensing AFM measurements in single QD-DNA cascade constructs, and temperature-dependent ensemble devices using TiO2 nanotubes, we show that Dexter energy transfer, likely mediated by the exciton-shelves formed in these QD-DNA self-assembled structures, can be used for efficient transport of energy across QD-DNA thin films.The size-dependent energy bandgaps of semiconductor nanocrystals or quantum dots (QDs) can be utilized in converting broadband incident radiation efficiently into electric current by cascade energy transfer (ET) between layers of different sized quantum dots, followed by charge dissociation and transport in the bottom layer. Self-assembling such cascade structures with angstrom-scale spatial precision is important for building realistic devices, and DNA-based QD self-assembly can provide an important alternative. Here we show long-range Dexter energy transfer in QD-DNA self-assembled single constructs and ensemble devices. Using photoluminescence, scanning tunneling spectroscopy, current-sensing AFM measurements in single QD-DNA cascade constructs, and temperature-dependent ensemble devices using TiO2 nanotubes, we show that Dexter energy transfer, likely mediated by the exciton-shelves formed in these QD-DNA self-assembled structures, can be used for efficient

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

Directory of Open Access Journals (Sweden)

Lu Lizhi

2006-12-01

Full Text Available Abstract Background Recently, a small population of cancer stem cells in adult and pediatric brain tumors has been identified. Some evidence has suggested that CD133 is a marker for a subset of leukemia and glioblastoma cancer stem cells. Especially, CD133 positive cells isolated from human glioblastoma may initiate tumors and represent novel targets for therapeutics. The gene expression and the drug resistance property of CD133 positive cancer stem cells, however, are still unknown. Results In this study, by FACS analysis we determined the percentage of CD133 positive cells in three primary cultured cell lines established from glioblastoma patients 10.2%, 69.7% and 27.5%, respectively. We also determined the average mRNA levels of markers associated with neural precursors. For example, CD90, CD44, CXCR4, Nestin, Msi1 and MELK mRNA on CD133 positive cells increased to 15.6, 5.7, 337.8, 21.4, 84 and 1351 times, respectively, compared to autologous CD133 negative cells derived from cell line No. 66. Additionally, CD133 positive cells express higher levels of BCRP1 and MGMT mRNA, as well as higher mRNA levels of genes that inhibit apoptosis. Furthermore, CD133 positive cells were significantly resistant to chemotherapeutic agents including temozolomide, carboplatin, paclitaxel (Taxol and etoposide (VP16 compared to autologous CD133 negative cells. Finally, CD133 expression was significantly higher in recurrent GBM tissue obtained from five patients as compared to their respective newly diagnosed tumors. Conclusion Our study for the first time provided evidence that CD133 positive cancer stem cells display strong capability on tumor's resistance to chemotherapy. This resistance is probably contributed by the CD133 positive cell with higher expression of on BCRP1 and MGMT, as well as the anti-apoptosis protein and inhibitors of apoptosis protein families. Future treatment should target this small population of CD133 positive cancer stem cells in

Numerical simulation on range of high-energy electron moving in accelerator target

International Nuclear Information System (INIS)

Shao Wencheng; Sun Punan; Dai Wenjiang

2008-01-01

In order to determine the range of high-energy electron moving in accelerator target, the range of electron with the energy range of 1 to 100 MeV moving in common target material of accelerator was calculated by Monte-Carlo method. Comparison between the calculated result and the published data were performed. The results of Monte-Carlo calculation are in good agreement with the published data. Empirical formulas were obtained for the range of high-energy electron with the energy range of 1 to 100 MeV in common target material by curve fitting, offering a series of referenced data for the design of targets in electron accelerator. (authors)

Study of the 2H(p,γ)3He reaction in the Big Bang Nucleosynthesis energy range at LUNA

Science.gov (United States)

Mossa, Viviana

2018-01-01

Deuterium is the first nucleus produced in the Universe, whose accumulation marks the beginning of the so called Big Bang Nucleosynthesis (BBN). Its primordial abundance is very sensitive to some cosmological parameters like the baryon density and the number of the neutrino families. Presently the main obstacle to an accurate theoretical deuterium abundance evaluation is due to the poor knowledge of the 2H(p,γ)3He cross section at BBN energies. The aim of the present work is to describe the experimental approach proposed by the LUNA collaboration, whose goal is to measure, with unprecedented precision, the total and the differential cross section of the reaction in the 30 < Ec.m. [keV] < 300 energy range.

The astrophysical S-factor for dd-reactions at keV-energy range

International Nuclear Information System (INIS)

Bystritskii, V.; Bystritsky, V.; Chaikovsky, S.

2001-01-01

The experimental results of measurements of the astrophysical S-factor for dd-reaction at keV-energy range collision energies using liner plasma technique are presented. The experiments were carried out at the high current generator of the Institute of High-Current Electronics in Tomsk, Russia. The measured values of the S-factors for the deuteron collision energies 1.80, 2.06 and 2.27 keV are S dd =(114±68), (64±30), (53±16) b x keV, respectively. The corresponding cross sections for dd-reactions, described as a product of the barrier factor and measured astrophysical S-factor, are σ dd n (E col =1.80 keV)=(4.3±2.6) x 10 -33 cm 2 ; σ dd n (E col =2.06 keV)=(9.8±4.6) x 10 -33 cm 2 ; σ dd n (E col =2.27 keV)=(2.1±0.6) x 10 -32 cm 2 . (orig.) [de

CD133, Selectively Targeting the Root of Cancer

Directory of Open Access Journals (Sweden)

Jörg U. Schmohl

2016-05-01

Full Text Available Cancer stem cells (CSC are capable of promoting tumor initiation and self-renewal, two important hallmarks of carcinoma formation. This population comprises a small percentage of the tumor mass and is highly resistant to chemotherapy, causing the most difficult problem in the field of cancer research, drug refractory relapse. Many CSC markers have been reported. One of the most promising and perhaps least ubiquitous is CD133, a membrane-bound pentaspan glycoprotein that is frequently expressed on CSC. There is evidence that directly targeting CD133 with biological drugs might be the most effective way to eliminate CSC. We have investigated two entirely unrelated, but highly effective approaches for selectively targeting CD133. The first involves using a special anti-CD133 single chain variable fragment (scFv to deliver a catalytic toxin. The second utilizes this same scFv to deliver components of the immune system. In this review, we discuss the development and current status of these CD133 associated biological agents. Together, they show exceptional promise by specific and efficient CSC elimination.

R-matrix analysis of 235U neutron transmission and cross sections in the energy range 0 to 2.25 keV

International Nuclear Information System (INIS)

Leal, L.C.; Derrien, H.; Larson, N.M.; Wright, R.Q.

1997-11-01

This document describes a new R-matrix analysis of 235 U cross section data in the energy range from 0 to 2,250 eV. The analysis was performed with the computer code SAMMY, that has recently been updated to permit, for the first time, inclusion of both differential and integral data within the analysis process. Fourteen differential data sets and six integral quantities were used in this evaluation: two measurements of fission plus capture, one of fission plus absorption, six of fission alone, two of transmission, and one of eta, plus standard values of thermal cross sections for fission, capture, and scattering, and of K1 and the Westcott g-factors for both fission and absorption. An excellent representation was obtained for the high-resolution transmission, fission, and capture cross-section data as well as for the integral quantities. The result is a single set of resonance parameters spanning the entire range up to 2,250 eV, a decided improvement over the present ENDF/VI evaluation, in which eleven discrete resonance parameter sets are required to cover that same energy range. This new evaluation is expected to greatly improve predictability of the criticality safety margins for nuclear systems in which 235 U is present

Ion range estimation by using dual energy computed tomography

Energy Technology Data Exchange (ETDEWEB)

Huenemohr, Nora; Greilich, Steffen [German Cancer Research Center (DKFZ), Heidelberg (Germany). Medical Physics in Radiation Oncology; Krauss, Bernhard [Siemens AG, Forchheim (Germany). Imaging and Therapy; Dinkel, Julien [German Cancer Research Center (DKFZ), Heidelberg (Germany). Radiology; Massachusetts General Hospital, Boston, MA (United States). Radiology; Gillmann, Clarissa [German Cancer Research Center (DKFZ), Heidelberg (Germany). Medical Physics in Radiation Oncology; University Hospital Heidelberg (Germany). Radiation Oncology; Ackermann, Benjamin [Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg (Germany); Jaekel, Oliver [German Cancer Research Center (DKFZ), Heidelberg (Germany). Medical Physics in Radiation Oncology; Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg (Germany); University Hospital Heidelberg (Germany). Radiation Oncology

2013-07-01

Inaccurate conversion of CT data to water-equivalent path length (WEPL) is one of the most important uncertainty sources in ion treatment planning. Dual energy CT (DECT) imaging might help to reduce CT number ambiguities with the additional information. In our study we scanned a series of materials (tissue substitutes, aluminum, PMMA, and other polymers) in the dual source scanner (Siemens Somatom Definition Flash). Based on the 80 kVp/140Sn kVp dual energy images, the electron densities Q{sub e} and effective atomic numbers Z{sub eff} were calculated. We introduced a new lookup table that translates the Q{sub e} to the WEPL. The WEPL residuals from the calibration were significantly reduced for the investigated tissue surrogates compared to the empirical Hounsfield-look-up table (single energy CT imaging) from (-1.0 {+-} 1.8)% to (0.1 {+-} 0.7)% and for non-tissue equivalent PMMA from -7.8% to -1.0%. To assess the benefit of the new DECT calibration, we conducted a treatment planning study for three different idealized cases based on tissue surrogates and PMMA. The DECT calibration yielded a significantly higher target coverage in tissue surrogates and phantom material (i.e. PMMA cylinder, mean target coverage improved from 62% to 98%). To verify the DECT calibration for real tissue, ion ranges through a frozen pig head were measured and compared to predictions calculated by the standard single energy CT calibration and the novel DECT calibration. By using this method, an improvement of ion range estimation from -2.1% water-equivalent thickness deviation (single energy CT) to 0.3% (DECT) was achieved. If one excludes raypaths located on the edge of the sample accompanied with high uncertainties, no significant difference could be observed. (orig.)

Calibration efficiency of HPGe detector in the 50-1800 KeV energy range

International Nuclear Information System (INIS)

Venturini, Luzia

1996-01-01

This paper describes the efficiency of an HPGe detector in the 50 - 1800 keV energy range, for two geometries for water measurements: Marinelli breaker (850 ml) and a polyethylene flask (100 ml). The experimental data were corrected for the summing effect and fitted to a continuous, differentiable and energy dependent function given by 1n(ε)=b 0 +b 1 .1n(E/E 0 )+ β.1n(E/E 0 ) 2 , where β = b 2 if E>E 0 and β =a 2 if E ≤E 0 ; ε = the full absorption peak efficiency; E is the gamma-ray energy and {b 0 , b 1 , b 2 , a 2 , E 0 } is the parameter set to be fitted. (author)

Iodine 131 and 133 as Fission Indicators

Energy Technology Data Exchange (ETDEWEB)

Broda, E.

1944-07-01

This report was written by E. Broda at the Cavendish Laboratory (Cambridge) in September 1944 and is about the possible use of Iodine 131 and 133 as fission indicators. Additionally, the description of the chemical procedure for I 131 and I 133 and the corresponding results can be found in this report. (nowak)

Mesenchymal stem cell-like properties of CD133+ glioblastoma initiating cells

Science.gov (United States)

Pavon, Lorena Favaro; Sibov, Tatiana Tais; de Oliveira, Daniela Mara; Marti, Luciana C.; Cabral, Francisco Romero; de Souza, Jean Gabriel; Boufleur, Pamela; Malheiros, Suzana M.F.; de Paiva Neto, Manuel A.; da Cruz, Edgard Ferreira; Chudzinski-Tavassi, Ana Marisa; Cavalheiro, Sérgio

2016-01-01

Glioblastoma is composed of dividing tumor cells, stromal cells and tumor initiating CD133+ cells. Recent reports have discussed the origin of the glioblastoma CD133+ cells and their function in the tumor microenvironment. The present work sought to investigate the multipotent and mesenchymal properties of primary highly purified human CD133+ glioblastoma-initiating cells. To accomplish this aim, we used the following approaches: i) generation of tumor subspheres of CD133+ selected cells from primary cell cultures of glioblastoma; ii) analysis of the expression of pluripotency stem cell markers and mesenchymal stem cell (MSC) markers in the CD133+ glioblastoma-initiating cells; iii) side-by-side ultrastructural characterization of the CD133+ glioblastoma cells, MSC and CD133+ hematopoietic stem cells isolated from human umbilical cord blood (UCB); iv) assessment of adipogenic differentiation of CD133+ glioblastoma cells to test their MSC-like in vitro differentiation ability; and v) use of an orthotopic glioblastoma xenograft model in the absence of immune suppression. We found that the CD133+ glioblastoma cells expressed both the pluripotency stem cell markers (Nanog, Mush-1 and SSEA-3) and MSC markers. In addition, the CD133+ cells were able to differentiate into adipocyte-like cells. Transmission electron microscopy (TEM) demonstrated that the CD133+ glioblastoma-initiating cells had ultrastructural features similar to those of undifferentiated MSCs. In addition, when administered in vivo to non-immunocompromised animals, the CD133+ cells were also able to mimic the phenotype of the original patient's tumor. In summary, we showed that the CD133+ glioblastoma cells express molecular signatures of MSCs, neural stem cells and pluripotent stem cells, thus possibly enabling differentiation into both neural and mesodermal cell types. PMID:27244897

Determination of peripheral hemodynamics by 133Xe muscle clearance in sauna treatment of arterial essential hypertension (stage 1 and 2)

International Nuclear Information System (INIS)

Siewert, H.; Winterfeld, H.J.; Strangfeld, D.

1982-01-01

In patients with essential hypertension under permanent propanolol treatment the muscular blood supply and the decreasing blood pressure was determined after sauna treatment using the 133 Xe muscle clearance method. Significant decrease of the blood pressure was reached already after 2 weeks sauna treatment twice a week. Continuation of sauna therapy led to permanently decreased blood pressure. The half-life period of the 133 Xe muscle clearance was significantly shortened and the functional vascular cross-section was increased. The blood pressure increased again after sauna treatment only once a week and became manifest in the prolongation of the half-life period as well as in the reduction of the functional vascular cross-section

Transcript of the proceedings of the first Albuquerque informal range/energy workshop

International Nuclear Information System (INIS)

Brice, D.K.

1981-04-01

An informal workshop was held to discuss aspects of the calculation of range and energy deposition distributions which are of interest in ion implantation experiments. Topics covered include: problems encountered in using published range and energy deposition tabulations; some limitations in the solutions of range/energy transport equations; the effect of the scattering cross section on straggle; Monte Carlo calculations of ranges and straggling; damage studies in aluminum; simulation of heavy-ion irradiation of gold using MARLOWE; and MARLOWE calculations of range distribution parameters - dependence on input data and calculational model

Sox2, a stemness gene, regulates tumor-initiating and drug-resistant properties in CD133-positive glioblastoma stem cells

Directory of Open Access Journals (Sweden)

Wen-Shin Song

2016-10-01

Conclusion: SOX2 plays a crucial role in regulating tumorigenicity in CD133+ GBM cells. Our results not only revealed the genetic plasticity contributing to drug resistance and stemness but also demonstrated the dominant role of SOX2 in maintenance of GBM CSCs, which may provide a novel therapeutic target to overcome the conundrum of poor survival of brain cancers.

Correlation between blister skin thickness, the maximum in the damage-energy distribution, and projected ranges of helium ions in Nb for the energy range 10 to 1500 keV

International Nuclear Information System (INIS)

St-Jacques, R.G.; Martel, J.G.; Terreault, B.; Veilleux, G.; Das, S.K.; Kaminsky, M.; Fenske, G.

1976-01-01

The skin thickness of blisters formed on polycrystalline niobium by 4 He + irradiation at room temperature for energies from 15 to 80 keV have been measured. Similar measurements were conducted for 10 keV 4 He + irradiation at 500 0 C to increase blister exfoliation, and thereby allow examination of a larger number of blister skins. For energies smaller than 100 keV the skin thicknesses are compared with the projected range and the damage-energy distributions constructed from moments interpolated from Winterbon's tabulated values. For energies of 10 and 15 keV the projected ranges and damage-energy distributions have also been computed with a Monte Carlo program. For energies larger than 100 keV the projected ranges of 4 He + in Nb were calculated using either Brice's formalism or the one given by Schiott. The thicknesses for 60 and 80 keV, and those reported earlier for 100 to 1500 keV correlate well with calculated projected ranges. For energies lower than 60 keV the measured thicknesses are larger than the calculated ranges

Low energy range dielectronic recombination of Fluorine-like Fe17+ at the CSRm

Science.gov (United States)

Khan, Nadir; Huang, Zhong-Kui; Wen, Wei-Qiang; Mahmood, Sultan; Dou, Li-Jun; Wang, Shu-Xing; Xu, Xin; Wang, Han-Bing; Chen, Chong-Yang; Chuai, Xiao-Ya; Zhu, Xiao-Long; Zhao, Dong-Mei; Mao, Li-Jun; Li, Jie; Yin, Da-Yu; Yang, Jian-Cheng; Yuan, You-Jin; Zhu, Lin-Fan; Ma, Xin-Wen

2018-05-01

The accuracy of dielectronic recombination (DR) data for astrophysics related ions plays a key role in astrophysical plasma modeling. The absolute DR rate coefficient of Fe17+ ions was measured at the main cooler storage ring at the Institute of Modern Physics, Lanzhou, China. The experimental electron-ion collision energy range covers the first Rydberg series up to n = 24 for the DR resonances associated with the {}2P1/2\\to {}2P3/2{{Δ }}n=0 core excitations. A theoretical calculation was performed by using FAC code and compared with the measured DR rate coefficient. Overall reasonable agreement was found between the experimental results and calculations. Moreover, the plasma rate coefficient was deduced from the experimental DR rate coefficient and compared with the available results from the literature. At the low energy range, significant discrepancies were found, and the measured resonances challenge state-of-the-art theory at low collision energies. Supported by the National Key R&D Program of China (2017YFA0402300), the National Natural Science Foundation of China through (11320101003, U1732133, 11611530684) and Key Research Program of Frontier Sciences, CAS (QYZDY-SSW-SLH006)

Long-Range Energy Propagation in Nanometer Arrays of Light Harvesting Antenna Complexes

NARCIS (Netherlands)

Escalantet, Maryana; Escalante Marun, M.; Lenferink, Aufrid T.M.; Zhao, Yiping; Tas, Niels Roelof; Huskens, Jurriaan; Hunter, C. Neil; Subramaniam, Vinod; Otto, Cornelis

2010-01-01

Here we report the first observation of long-range transport of excitation energy within a biomimetic molecular nanoarray constructed from LH2 antenna complexes from Rhodobacter sphaeroides. Fluorescence microscopy of the emission of light after local excitation with a diffraction-limited light beam

Blocking the NOTCH pathway can inhibit the growth of CD133-positive A549 cells and sensitize to chemotherapy

Energy Technology Data Exchange (ETDEWEB)

Liu, Juntao; Mao, Zhangfan; Huang, Jie; Xie, Songping; Liu, Tianshu; Mao, Zhifu, E-mail: 48151660@qq.com

2014-02-21

Highlights: • Notch signaling pathway members are expressed lower levels in CD133+ cells. • CD133+ cells are not as sensitive as CD133− cells to chemotherapy. • GSI could inhibit the growth of both CD133+ and CD133− cells. • Blockade of Notch signaling pathway enhanced the effect of chemotherapy with CDDP. • DAPT/CDDP co-therapy caused G2/M arrest and elimination in CD133+ cells. - Abstract: Cancer stem cells (CSCs) are believed to play an important role in tumor growth and recurrence. These cells exhibit self-renewal and proliferation properties. CSCs also exhibit significant drug resistance compared with normal tumor cells. Finding new treatments that target CSCs could significantly enhance the effect of chemotherapy and improve patient survival. Notch signaling is known to regulate the development of the lungs by controlling the cell-fate determination of normal stem cells. In this study, we isolated CSCs from the human lung adenocarcinoma cell line A549. CD133 was used as a stem cell marker for fluorescence-activated cell sorting (FACS). We compared the expression of Notch signaling in both CD133+ and CD133− cells and blocked Notch signaling using the γ-secretase inhibitor DAPT (GSI-IX). The effect of combining GSI and cisplatin (CDDP) was also examined in these two types of cells. We observed that both CD133+ and CD133− cells proliferated at similar rates, but the cells exhibited distinctive differences in cell cycle progression. Few CD133+ cells were observed in the G{sub 2}/M phase, and there were half as many cells in S phase compared with the CD133− cells. Furthermore, CD133+ cells exhibited significant resistance to chemotherapy when treated with CDDP. The expression of Notch signaling pathway members, such as Notch1, Notch2 and Hes1, was lower in CD133+ cells. GSI slightly inhibited the proliferation of both cell types and exhibited little effect on the cell cycle. The inhibitory effects of DPP on these two types of cells were

Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells

International Nuclear Information System (INIS)

Suetsugu, Atsushi; Nagaki, Masahito; Aoki, Hitomi; Motohashi, Tsutomu; Kunisada, Takahiro; Moriwaki, Hisataka

2006-01-01

The CD133 antigen, identified as a hematopoietic stem cell marker, appears in various human embryonic epithelia including the neural tube, gut, and kidney. We herein investigated whether CD133 + cells isolated from human hepatocellular carcinoma cell lines possess cancer stem/progenitor cell-like properties. Among the three cell lines studied, the CD133 antigen was found to be expressed only on the surface of Huh-7 cells. CD133 + cells from Huh-7 performed a higher in vitro proliferative potential and lower mRNA expressions of mature hepatocyte markers, glutamine synthetase and cytochrome P450 3A4, than CD133 - population of Huh-7 cells. When either CD133 + or CD133 - cells were subcutaneously injected into SCID mice, CD133 + cells formed tumors, whereas CD133 - cells induced either a very small number of tumors or none at all. Taken together, the identification of CD133 + cells could thus be a potentially powerful tool to investigate the tumorigenic process in the hepatoma system and to also develop effective therapies targeted against hepatocellular carcinoma

Mid-range adiabatic wireless energy transfer via a mediator coil

International Nuclear Information System (INIS)

Rangelov, A.A.; Vitanov, N.V.

2012-01-01

A technique for efficient mid-range wireless energy transfer between two coils via a mediator coil is proposed. By varying the coil frequencies, three resonances are created: emitter–mediator (EM), mediator–receiver (MR) and emitter–receiver (ER). If the frequency sweeps are adiabatic and such that the EM resonance precedes the MR resonance, the energy flows sequentially along the chain emitter–mediator–receiver. If the MR resonance precedes the EM resonance, then the energy flows directly from the emitter to the receiver via the ER resonance; then the losses from the mediator are suppressed. This technique is robust against noise, resonant constraints and external interferences. - Highlights: ► Efficient and robust mid-range wireless energy transfer via a mediator coil. ► The adiabatic energy transfer is analogous to adiabatic passage in quantum optics. ► Wireless energy transfer is insensitive to any resonant constraints. ► Wireless energy transfer is insensitive to noise in the neighborhood of the coils.

19 CFR 133.21 - Articles bearing counterfeit trademarks.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Articles bearing counterfeit trademarks. 133.21... Recorded Trademarks or Recorded Trade Names § 133.21 Articles bearing counterfeit trademarks. (a... substantially indistinguishable from, a registered trademark. (b) Seizure. Any article of domestic or foreign...

Battery electric vehicle energy consumption modelling for range estimation

NARCIS (Netherlands)

Wang, J.; Besselink, I.J.M.; Nijmeijer, H.

2017-01-01

Range anxiety is considered as one of the major barriers to the mass adoption of battery electric vehicles (BEVs). One method to solve this problem is to provide accurate range estimation to the driver. This paper describes a vehicle energy consumption model considering the influence of weather

Mechanism of long-range penetration of low-energy ions in botanic samples

International Nuclear Information System (INIS)

Liu Feng; Wang Yugang; Xue Jianming; Wang Sixue; Du Guanghua; Yan Sha; Zhao Weijiang

2002-01-01

The authors present experimental evidence to reveal the mechanism of long-range penetration of low-energy ions in botanic samples. In the 100 keV Ar + ion transmission measurement, the result confirmed that low-energy ions could penetrate at least 60 μm thick kidney bean slices with the probability of about 1.0 x 10 -5 . The energy spectrum of 1 MeV He + ions penetrating botanic samples has shown that there is a peak of the count of ions with little energy loss. The probability of the low-energy ions penetrating the botanic sample is almost the same as that of the high-energy ions penetrating the same samples with little energy loss. The results indicate that there are some micro-regions with mass thickness less than the projectile range of low-energy ions in the botanic samples and they result in the long-range penetration of low-energy ions in botanic samples

Correlation of optical energy gap with the nearest neighbour short range order in amorphous V2O5 films

International Nuclear Information System (INIS)

Dhawan, Sahil; Vedeshwar, Agnikumar G; Tandon, R P

2011-01-01

The optical and structural properties of well characterized vacuum-evaporated amorphous V 2 O 5 films were studied in the thickness range 5-500 nm. The structural analyses show that V-O, O-O and V-V nearest neighbour distances defining the short range order vary nonlinearly with film thickness. The optical absorption shows thickness-dependent energy gap (E g ) and the nonlinear behaviour of thickness-dependent E g is similar to that of nearest neighbour distance with film thickness. The E g correlates linearly very well with all the three nearest neighbour distances. The variation of E g with film thickness is attributed to the residual stress in the film which causes the changes in short range order. The change in E g corresponding to the change in V-O distance was found to be 35 eV nm -1 . This change is almost three times of that with V-V distance.

Range and energy functions of interest in neutron dosimetry

International Nuclear Information System (INIS)

Bhatia, D.P.; Nagarajan, P.S.

1978-01-01

This report documents the energy and range functions generated and used in fast neutron interface dosimetry studies. The basic data of stopping power employed are the most recent. The present report covers a number of media mainly air, oxygen, nitrogen, polythene, graphite, bone and tissue, and a number of charged particles, namely protons, alphas, 9 Be, 11 B, 12 C, 13 C, 14 N and 16 O. These functions would be useful for generation of energy and range values for any of the above particles in any of the above media within +- 1% in any dosimetric calculations. (author)

CD133 is a marker of bioenergetic stress in human glioma.

Directory of Open Access Journals (Sweden)

Corinne E Griguer

Full Text Available Mitochondria dysfunction and hypoxic microenvironment are hallmarks of cancer cell biology. Recently, many studies have focused on isolation of brain cancer stem cells using CD133 expression. In this study, we investigated whether CD133 expression is regulated by bioenergetic stresses affecting mitochondrial functions in human glioma cells. First, we determined that hypoxia induced a reversible up-regulation of CD133 expression. Second, mitochondrial dysfunction through pharmacological inhibition of the Electron Transport Chain (ETC produced an up-regulation of CD133 expression that was inversely correlated with changes in mitochondrial membrane potential. Third, generation of stable glioma cells depleted of mitochondrial DNA showed significant and stable increases in CD133 expression. These glioma cells, termed rho(0 or rho(0, are characterized by an exaggerated, uncoupled glycolytic phenotype and by constitutive and stable up-regulation of CD133 through many cell passages. Moreover, these rho(0 cells display the ability to form "tumor spheroids" in serumless medium and are positive for CD133 and the neural progenitor cell marker, nestin. Under differentiating conditions, rho(0 cells expressed multi-lineage properties. Reversibility of CD133 expression was demonstrated by transfering parental mitochondria to rho(0 cells resulting in stable trans-mitochondrial "cybrid" clones. This study provides a novel mechanistic insight about the regulation of CD133 by environmental conditions (hypoxia and mitochondrial dysfunction (genetic and chemical. Considering these new findings, the concept that CD133 is a marker of brain tumor stem cells may need to be revised.

6 CFR 13.3 - Basis for civil penalties and assessments.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Basis for civil penalties and assessments. 13.3 Section 13.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.3 Basis for civil penalties and assessments. (a) Claims. (1) Except as provided in...

Electron response of some low-Z scintillators in wide energy range

International Nuclear Information System (INIS)

Swiderski, L; Marcinkowski, R; Moszynski, M; Czarnacki, W; Szawlowski, M; Szczesniak, T; Pausch, G; Plettner, C; Roemer, K

2012-01-01

Light yield nonproportionality and the intrinsic resolution of some low atomic number scintillators were studied by means of the Wide Angle Compton Coincidence (WACC) technique. The plastic and liquid scintillator response to Compton electrons was measured in the energy range of 10 keV up to 4 MeV, whereas a CaF 2 :Eu sample was scanned from 3 keV up to 1 MeV. The nonproportionality of the CaF 2 :Eu light yield has characteristics typical for inorganic scintillators of the multivalent halides group, whereas tested organic scintillators show steeply increasing nonproportionality without saturation point. This is in contrast to the behavior of all known inorganic scintillators having their nonproportionality curves at saturation above energies between tens and several hundred keV.

Electron response of some low-Z scintillators in wide energy range

Science.gov (United States)

Swiderski, L.; Marcinkowski, R.; Moszynski, M.; Czarnacki, W.; Szawlowski, M.; Szczesniak, T.; Pausch, G.; Plettner, C.; Roemer, K.

2012-06-01

Light yield nonproportionality and the intrinsic resolution of some low atomic number scintillators were studied by means of the Wide Angle Compton Coincidence (WACC) technique. The plastic and liquid scintillator response to Compton electrons was measured in the energy range of 10 keV up to 4 MeV, whereas a CaF2:Eu sample was scanned from 3 keV up to 1 MeV. The nonproportionality of the CaF2:Eu light yield has characteristics typical for inorganic scintillators of the multivalent halides group, whereas tested organic scintillators show steeply increasing nonproportionality without saturation point. This is in contrast to the behavior of all known inorganic scintillators having their nonproportionality curves at saturation above energies between tens and several hundred keV.

Investigation of EBT2 and EBT3 films for proton dosimetry in the 4-20 MeV energy range.

Science.gov (United States)

Reinhardt, S; Würl, M; Greubel, C; Humble, N; Wilkens, J J; Hillbrand, M; Mairani, A; Assmann, W; Parodi, K

2015-03-01

Radiochromic films such as Gafchromic EBT2 or EBT3 films are widely used for dose determination in radiation therapy because they offer a superior spatial resolution compared to any other digital dosimetric 2D detector array. The possibility to detect steep dose gradients is not only attractive for intensity-modulated radiation therapy with photons but also for intensity-modulated proton therapy. Their characteristic dose rate-independent response makes radiochromic films also attractive for dose determination in cell irradiation experiments using laser-driven ion accelerators, which are currently being investigated as future medical ion accelerators. However, when using these films in ion beams, the energy-dependent dose response in the vicinity of the Bragg peak has to be considered. In this work, the response of these films for low-energy protons is investigated. To allow for reproducible and background-free irradiation conditions, the films were exposed to mono-energetic protons from an electrostatic accelerator, in the 4-20 MeV energy range. For comparison, irradiation with clinical photons was also performed. It turned out that in general, EBT2 and EBT3 films show a comparable performance. For example, dose-response curves for photons and protons with energies as low as 11 MeV show almost no differences. However, corrections are required for proton energies below 11 MeV. Care has to be taken when correction factors are related to an average LET from depth-dose measurements, because only the dose-averaged LET yields similar results as obtained in mono-energetic measurements.

29 CFR 4.133 - Beneficiary of contract services.

Science.gov (United States)

2010-07-01

... service and laundry and dry cleaning service for personnel at military installations. Furthermore, there... 29 Labor 1 2010-07-01 2010-07-01 true Beneficiary of contract services. 4.133 Section 4.133 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Application of the...

Darwin: Dose monitoring system applicable to various radiations with wide energy ranges

International Nuclear Information System (INIS)

Sato, T.; Satoh, D.; Endo, A.; Yamaguchi, Y.

2007-01-01

A new radiation dose monitor, designated as DARWIN (Dose monitoring system Applicable to various Radiations with Wide energy ranges), has been developed for real-time monitoring of doses in workspaces and surrounding environments of high-energy accelerator facilities. DARWIN is composed of a Phoswitch-type scintillation detector, which consists of liquid organic scintillator BC501A coupled with ZnS(Ag) scintillation sheets doped with 6 Li, and a data acquisition system based on a Digital-Storage-Oscilloscope. DARWIN has the following features: (1) capable of monitoring doses from neutrons, photons and muons with energies from thermal energy to 1 GeV, 150 keV to 100 MeV and 1 MeV to 100 GeV, respectively, (2) highly sensitive with precision and (3) easy to operate with a simple graphical user-interface. The performance of DARWIN was examined experimentally in several radiation fields. The results of the experiments indicated the accuracy and wide response range of DARWIN for measuring dose rates from neutrons, photons and muons with wide energies. It was also found from the experiments that DARWIN enables us to monitor small fluctuations of neutron dose rates near the background level because of its high sensitivity. With these properties, DARWIN will be able to play a very important role for improving radiation safety in high-energy accelerator facilities. (authors)

Electron beam absorption in solid and in water phantoms: depth scaling and energy-range relations

International Nuclear Information System (INIS)

Grosswendt, B.; Roos, M.

1989-01-01

In electron dosimetry energy parameters are used with values evaluated from ranges in water. The electron ranges in water may be deduced from ranges measured in solid phantoms. Several procedures recommended by national and international organisations differ both in the scaling of the ranges and in the energy-range relations for water. Using the Monte Carlo method the application of different procedures for electron energies below 10 MeV is studied for different phantom materials. It is shown that deviations in the range scaling and in the energy-range relations for water may accumulate to give energy errors of several per cent. In consequence energy-range relations are deduced for several solid phantom materials which enable a single-step energy determination. (author)

Possible manifestation of long range forces in high energy hadron collisions

International Nuclear Information System (INIS)

Kuraev, Eh.A.; Ferro, P.; Trentadue, L.

1997-01-01

Pion-pion and photon-photon scattering are discussed.. We obtain, starting from the impact representation introduced by Cheng and Wu a new contribution to the high energy hadron-hadron scattering amplitude for small transferred momentum q 2 of the form is (q 2 /m 4 )ln(-q 2 /m 2 ). This behaviour may be interpreted as a manifestation of long transverse-range forces between hadrons which, for ρ>> m -1 fall off as ρ -4 . We consider the examples of pion and photon scattering with photons converted in the intermediate state to two pairs of quarks interacting by exchanging two gluon colorless state. A phenomenological approach for proton impact factor is used to analyze proton-proton scattering. The analysis of the lowest order radiative corrections for the case of photon-photon scattering is done. We discuss the possibility of observing the effects of these long range forces

Energy- and time-resolved detection of prompt gamma-rays for proton range verification.

Science.gov (United States)

Verburg, Joost M; Riley, Kent; Bortfeld, Thomas; Seco, Joao

2013-10-21

In this work, we present experimental results of a novel prompt gamma-ray detector for proton beam range verification. The detection system features an actively shielded cerium-doped lanthanum(III) bromide scintillator, coupled to a digital data acquisition system. The acquisition was synchronized to the cyclotron radio frequency to separate the prompt gamma-ray signals from the later-arriving neutron-induced background. We designed the detector to provide a high energy resolution and an effective reduction of background events, enabling discrete proton-induced prompt gamma lines to be resolved. Measuring discrete prompt gamma lines has several benefits for range verification. As the discrete energies correspond to specific nuclear transitions, the magnitudes of the different gamma lines have unique correlations with the proton energy and can be directly related to nuclear reaction cross sections. The quantification of discrete gamma lines also enables elemental analysis of tissue in the beam path, providing a better prediction of prompt gamma-ray yields. We present the results of experiments in which a water phantom was irradiated with proton pencil-beams in a clinical proton therapy gantry. A slit collimator was used to collimate the prompt gamma-rays, and measurements were performed at 27 positions along the path of proton beams with ranges of 9, 16 and 23 g cm(-2) in water. The magnitudes of discrete gamma lines at 4.44, 5.2 and 6.13 MeV were quantified. The prompt gamma lines were found to be clearly resolved in dimensions of energy and time, and had a reproducible correlation with the proton depth-dose curve. We conclude that the measurement of discrete prompt gamma-rays for in vivo range verification of clinical proton beams is feasible, and plan to further study methods and detector designs for clinical use.

16 CFR 1500.133 - Extremely flammable contact adhesives; labeling.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Extremely flammable contact adhesives... REGULATIONS § 1500.133 Extremely flammable contact adhesives; labeling. (a) Extremely flammable contact adhesives, also known as contact bonding cements, when distributed in containers intended or suitable for...

Liquid argon as an electron/photon detector in the energy range of 50 MeV to 2 GeV: a Monte Carlo investigation

International Nuclear Information System (INIS)

Goodman, M.S.; Denis, G.; Hall, M.; Karpovsky, A.; Wilson, R.; Gabriel, T.A.; Bishop, B.L.

1980-12-01

Monte Carlo techniques which have been used to study the characteristics of a proposed electron/photon detector based on the total absorption of electromagnetic showers in liquid argon have been investigated. The energy range studied was 50 MeV to 2 GeV. Results are presented on the energy and angular resolution predicted for the device, along with the detailed predictions of the transverse and longitudinal shower distributions. Comparisons are made with other photon detectors, and possible applications are discussed

Study of regional lung ventilation and perfusion by xenon 133

International Nuclear Information System (INIS)

Lombard, Yves.

1976-01-01

The present work consists of a regional lung exploration after injection of xenon 133, dissolved in physiological serum, followed a few minutes later by that of 99m Tc-labelled serumalbumin microspheres. The aim is three fold: first of all to study perfusion and ventilation by xenon 133, next to compare the results obtained after xenon 133 and 99 m Tc-labelled microsphere injection, lastly to establish the value of the technique and its routine application. This examination has not solved all problems of lung exploration by xenon 133. For example we deliberately kept to intraveinous injection of the gas dissolved in physiological serum, leaving aside the breathing test. Xenon 133 scintigraphy in our opinion will not tend to replace 99m Tc-labelled microsphere scintigraphy, which has irreplaceable morphological qualities, but will serve as an excellent complement. The basic advantage of xenon 133 is the regional ventilation estimate it provides allowing any anomaly of the lung parenchyma to be located immediately or conversely the functional value of the healthy lung to be established with a view to a surgical removal of a diseased zone [fr

High-energy X-ray diffraction studies of short- and intermediate-range structure in oxide glasses

International Nuclear Information System (INIS)

Suzuya, Kentaro

2002-01-01

The feature of high-energy X-ray diffraction method is explained. The oxide glasses studies by using BL04B2, high-energy X-ray diffraction beam line of SPring-8, and the random system materials by high-energy monochromatic X-ray diffraction are introduced. An advantage of third generation synchrotron radiation is summarized. On SPring-8, the high-energy X-ray diffraction experiments of random system are carried out by BL04B2 and BL14B1 beam line. BL04B2 can select Si (111)(E=37.8 keV, λ=0.033 nm) and Si(220)(E=61.7 keV, λ=0.020 nm) as Si monochromator. The intermediate-range structure of (MgO) x (P 2 O 5 ) 1-x glass ,MgP 2 O 6 glass, B 2 O 3 glass, SiO 2 and GeO 2 are explained in detail. The future and application of high-energy X-ray diffraction are stated. (S.Y.)

Fragrance material review on 1-(3,3-dimethylcyclohexyl)ethan-1-one.

Science.gov (United States)

Scognamiglio, J; Letizia, C S; Api, A M

2013-12-01

A Toxicologic and Dermatologic review of 1-(3,3-dimethylcyclohexyl)ethan-1-one when used as a fragrance ingredient is presented. 1-(3,3-Dimethylcyclohexyl)ethan-1-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1-(3,3-dimethylcyclohexyl)ethan-1-one were evaluated then summarized and includes physical properties, skin irritation, mucous membrane (eye) irritation, skin sensitization, and genotoxicity data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al., 2013(1) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances. Copyright © 2013 Elsevier Ltd. All rights reserved.

46 CFR 108.133 - Hull superstructure, structural bulkheads, decks, and deckhouses.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Hull superstructure, structural bulkheads, decks, and deckhouses. 108.133 Section 108.133 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A... Protection § 108.133 Hull superstructure, structural bulkheads, decks, and deckhouses. Each hull...

Experimental investigation of dd reaction in range of ultralow energies using Z-pinch

International Nuclear Information System (INIS)

Bystritskij, V.M.; Grebenyuk, V.M.; Parzhitskij, S.S.

1998-01-01

Results of the experiments to measure the dd reaction cross section in the range of deuteron collision energies from 0.1 keV to 1.5 keV using Z-pinch technique are presented. The experiment was performed at the Pulsed Ion Beam Accelerator of the High-Current Electronics Institute in Tomsk. The dd fusion neutrons were registered by scintillation detectors using time-of-flight method and BF 3 detectors of thermal neutrons. At 90% confidence level, the upper limits of the neutron producing dd reaction cross sections are obtained for average deuteron collision energies of 0.11, 0.34, 0.37 and 1.46 keV. The results demonstrate that high-intensity pulsed accelerators with a generator current of 2-3 MA allow the dd reaction cross sections to be measured in the range of deuteron collision energies from 0.8 keV to 3 keV

Exposure mode study to xenon-133 in a reactor building

International Nuclear Information System (INIS)

Perier, Aurelien

2014-01-01

The work described in this thesis focuses on the external and internal dose assessment to xenon-133. During the nuclear reactor operation, fission products and radioactive inert gases, as 133 Xe, are generated and might be responsible for the exposure of workers in case of clad defect. Particle Monte Carlo transport code is adapted in radioprotection to quantify dosimetric quantities. The study of exposure to xenon-133 is conducted by using Monte-Carlo simulations based on GEANT4, an anthropomorphic phantom, a realistic geometry of the reactor building, and compartmental models. The external exposure inside a reactor building is conducted with a realistic and conservative exposure scenario. The effective dose rate and the eye lens equivalent dose rate are determined by Monte-Carlo simulations. Due to the particular emission spectrum of xenon-133, the equivalent dose rate to the lens of eyes is discussed in the light of expected new eye dose limits. The internal exposure occurs while xenon-133 is inhaled. The lungs are firstly exposed by inhalation, and their equivalent dose rate is obtained by Monte-Carlo simulations. A biokinetic model is used to evaluate the internal exposure to xenon-133. This thesis gives us a better understanding to the dosimetric quantities related to external and internal exposure to xenon-133. Moreover the impacts of the dosimetric changes are studied on the current and future dosimetric limits. The dosimetric quantities are lower than the current and future dosimetric limits. (author)

Correlation of circulating CD133+ progenitor subclasses with a mild phenotype in Duchenne muscular dystrophy patients.

Directory of Open Access Journals (Sweden)

Chiara Marchesi

2008-05-01

Full Text Available Various prognostic serum and cellular markers have been identified for many diseases, such as cardiovascular diseases and tumor pathologies. Here we assessed whether the levels of certain stem cells may predict the progression of Duchenne muscular dystrophy (DMD.The levels of several subpopulations of circulating stem cells expressing the CD133 antigen were determined by flow cytometry in 70 DMD patients. The correlation between the levels and clinical status was assessed by statistical analysis. The median (+/-SD age of the population was 10.66+/-3.81 (range 3 to 20 years. The levels of CD133+CXCR4+CD34- stem cells were significantly higher in DMD patients compared to healthy controls (mean+/-standard deviation: 17.38+/-1.38 vs. 11.0+/-1.70; P = 0.03 with a tendency towards decreased levels in older patients. Moreover, the levels of this subpopulation of cells correlated with the clinical condition. In a subgroup of 19 DMD patients after 24 months of follow-up, increased levels of CD133+CXCR4+CD34- cells was shown to be associated with a phenotype characterised by slower disease progression. The circulating CD133+CXCR4+CD34- cells in patients from different ages did not exhibit significant differences in their myogenic and endothelial in vitro differentiation capacity.Our results suggest that levels of CD133+CXCR4+CD34- could function as a new prognostic clinical marker for the progression of DMD.

Complete genome sequencing of Agrobacterium sp. H13-3, the former Rhizobium lupini H13-3, reveals a tripartite genome consisting of a circular and a linear chromosome and an accessory plasmid but lacking a tumor-inducing Ti-plasmid.

Science.gov (United States)

Wibberg, Daniel; Blom, Jochen; Jaenicke, Sebastian; Kollin, Florian; Rupp, Oliver; Scharf, Birgit; Schneiker-Bekel, Susanne; Sczcepanowski, Rafael; Goesmann, Alexander; Setubal, Joao Carlos; Schmitt, Rüdiger; Pühler, Alfred; Schlüter, Andreas

2011-08-20

Agrobacterium sp. H13-3, formerly known as Rhizobium lupini H13-3, is a soil bacterium that was isolated from the rhizosphere of Lupinus luteus. The isolate has been established as a model system for studying novel features of flagellum structure, motility and chemotaxis within the family Rhizobiaceae. The complete genome sequence of Agrobacterium sp. H13-3 has been established and the genome structure and phylogenetic assignment of the organism was analysed. For de novo sequencing of the Agrobacterium sp. H13-3 genome, a combined strategy comprising 454-pyrosequencing on the Genome Sequencer FLX platform and PCR-based amplicon sequencing for gap closure was applied. The finished genome consists of three replicons and comprises 5,573,770 bases. Based on phylogenetic analyses, the isolate could be assigned to the genus Agrobacterium biovar I and represents a genomic species G1 strain within this biovariety. The highly conserved circular chromosome (2.82 Mb) of Agrobacterium sp. H13-3 mainly encodes housekeeping functions characteristic for an aerobic, heterotrophic bacterium. Agrobacterium sp. H13-3 is a motile bacterium driven by the rotation of several complex flagella. Its behaviour towards external stimuli is regulated by a large chemotaxis regulon and a total of 17 chemoreceptors. Comparable to the genome of Agrobacterium tumefaciens C58, Agrobacterium sp. H13-3 possesses a linear chromosome (2.15 Mb) that is related to its reference replicon and features chromosomal and plasmid-like properties. The accessory plasmid pAspH13-3a (0.6 Mb) is only distantly related to the plasmid pAtC58 of A. tumefaciens C58 and shows a mosaic structure. A tumor-inducing Ti-plasmid is missing in the sequenced strain H13-3 indicating that it is a non-virulent isolate. Copyright © 2011 Elsevier B.V. All rights reserved.

Average fast neutron flux in three energy ranges in the Quinta assembly irradiated by two types of beams

Directory of Open Access Journals (Sweden)

Strugalska-Gola Elzbieta

2017-01-01

Full Text Available This work was performed within the international project “Energy plus Transmutation of Radioactive Wastes” (E&T - RAW for investigations of energy production and transmutation of radioactive waste of the nuclear power industry. 89Y (Yttrium 89 samples were located in the Quinta assembly in order to measure an average high neutron flux density in three different energy ranges using deuteron and proton beams from Dubna accelerators. Our analysis showed that the neutron density flux for the neutron energy range 20.8 - 32.7 MeV is higher than for the neutron energy range 11.5 - 20.8 MeV both for protons with an energy of 0.66 GeV and deuterons with an energy of 2 GeV, while for deuteron beams of 4 and 6 GeV we did not observe this.

33 CFR 133.1 - Purpose.

Science.gov (United States)

2010-07-01

... FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL LIABILITY TRUST FUND; STATE ACCESS § 133.1 Purpose. This... trust Fund (the Fund) for oil pollution removal costs under section 1012(d)(1) of the Oil Pollution Act...

/sup 133/Xe clearance technique in the assessment of hypogastric arteries insufficiency

Energy Technology Data Exchange (ETDEWEB)

Vattimo, A.; Setacci, C.; Lore, F.; Pisani, M.; Campoccia, G.

1982-10-01

The clearance of the radioactive inert gas /sup 133/Xenon injected intramuscularly in the gluteal region was studied in healthy subjects and in patients with aortoiliac disease, in order to measure the muscular blood flow (MBF) in the vascular bed of the hypogastric arteries. At rest MBF averaged 6.0 +- 2.1 SD ml/100 g per min in healthy subjects and 5.1 +- 2.7 ml/100 g per min in patients with arterial disease. After exercise-induced hyperemia, maximal MBF in healthy subjects averaged 121.6 +- 60.9 ml/100 g per min, a value markedly higher than the corresponding 6.0 +- 3.6 ml/100 g per min observed in vascular disease patients. The /sup 133/Xe values corresponded well, in patients with occlusive vascular disease, with the results obtained in the same subjects by measurement of the penile blood pressure using a Doppler shift ultrasound detector. The /sup 133/Xe clearance is a simple and reliable procedure, which could be particularly useful for an assessment of the conditions of hypogastric arteries prior to abdominal surgery.

The 133Xe clearance technique in the assessment of hypogastric arteries insufficiency

International Nuclear Information System (INIS)

Vattimo, A.; Setacci, C.; Lore, F.; Pisani, M.; Campoccia, G.

1982-01-01

The clearance of the radioactive inert gas 133 Xenon injected intramuscularly in the gluteal region was studied in healthy subjects and in patients with aortoiliac disease, in order to measure the muscular blood flow (MBF) in the vascular bed of the hypogastric arteries. At rest MBF averaged 6.0 +- 2.1 SD ml/100 g per min in healthy subjects and 5.1 +- 2.7 ml/100 g per min in patients with arterial disease. After exercise-induced hyperemia, maximal MBF in healthy subjects averaged 121.6 +- 60.9 ml/100 g per min, a value markedly higher than the corresponding 6.0 +- 3.6 ml/100 g per min observed in vascular disease patients. The 133 Xe values corresponded well, in patients with occlusive vascular disease, with the results obtained in the same subjects by measurement of the penile blood pressure using a Doppler shift ultrasound detector. The 133 Xe clearance is a simple and reliable procedure, which could be particularly useful for an assessment of the conditions of hypogastric arteries prior to abdominal surgery. (orig.) [de

Thermal decomposition of 1,3,3-trinitroazetidine (TNAZ): A density functional theory and ab initio study

International Nuclear Information System (INIS)

Veals, Jeffrey D.; Thompson, Donald L.

2014-01-01

Density functional theory and ab initio methods are employed to investigate decomposition pathways of 1,3,3-trinitroazetidine initiated by unimolecular loss of NO 2 or HONO. Geometry optimizations are performed using M06/cc-pVTZ and coupled-cluster (CC) theory with single, double, and perturbative triple excitations, CCSD(T), is used to calculate accurate single-point energies for those geometries. The CCSD(T)/cc-pVTZ energies for NO 2 elimination by N–N and C–N bond fission are, including zero-point energy (ZPE) corrections, 43.21 kcal/mol and 50.46 kcal/mol, respectively. The decomposition initiated by trans-HONO elimination can occur by a concerted H-atom and nitramine NO 2 group elimination or by a concerted H-atom and nitroalkyl NO 2 group elimination via barriers (at the CCSD(T)/cc-pVTZ level with ZPE corrections) of 47.00 kcal/mol and 48.27 kcal/mol, respectively. Thus, at the CCSD(T)/cc-pVTZ level, the ordering of these four decomposition steps from energetically most favored to least favored is: NO 2 elimination by N–N bond fission, HONO elimination involving the nitramine NO 2 group, HONO elimination involving a nitroalkyl NO 2 group, and finally NO 2 elimination by C–N bond fission

Thermal decomposition of 1,3,3-trinitroazetidine (TNAZ): A density functional theory and ab initio study

Science.gov (United States)

Veals, Jeffrey D.; Thompson, Donald L.

2014-04-01

Density functional theory and ab initio methods are employed to investigate decomposition pathways of 1,3,3-trinitroazetidine initiated by unimolecular loss of NO2 or HONO. Geometry optimizations are performed using M06/cc-pVTZ and coupled-cluster (CC) theory with single, double, and perturbative triple excitations, CCSD(T), is used to calculate accurate single-point energies for those geometries. The CCSD(T)/cc-pVTZ energies for NO2 elimination by N-N and C-N bond fission are, including zero-point energy (ZPE) corrections, 43.21 kcal/mol and 50.46 kcal/mol, respectively. The decomposition initiated by trans-HONO elimination can occur by a concerted H-atom and nitramine NO2 group elimination or by a concerted H-atom and nitroalkyl NO2 group elimination via barriers (at the CCSD(T)/cc-pVTZ level with ZPE corrections) of 47.00 kcal/mol and 48.27 kcal/mol, respectively. Thus, at the CCSD(T)/cc-pVTZ level, the ordering of these four decomposition steps from energetically most favored to least favored is: NO2 elimination by N-N bond fission, HONO elimination involving the nitramine NO2 group, HONO elimination involving a nitroalkyl NO2 group, and finally NO2 elimination by C-N bond fission.

Neutron radiative capture cross section of 232Th in the energy range 0.1 to 1.2 MeV

International Nuclear Information System (INIS)

Jain, H.M.; Kailas, S.

1987-01-01

Recently reported neutron radiative capture cross section of 232 Th measurements in the energy range 0.1 to 1.2 MeV are compared with the calculations based on the statistical model Hauser-Feshbach theory using the spherical optical model transmission coefficients and simple Fermi gas level density formula. The calculations are in good agreement with the recent experimental data, reproducing both the absolute magnitude and the shape exhibited by the excitation function. The results of this comparative study can be used for improving the evaluation of the neutron radiative capture cross section of 232 Th. 16 refs., 3 tables, 4 figures. (author)

Neutron radiative capture cross section of 232Th in the energy range 0.1 to 1.2 MeV

International Nuclear Information System (INIS)

Jain, H.M.; Kailas, S.

1987-03-01

Recently reported neutron radiative capture cross section of Th-232 measurements in the energy range 0.1 to 1.2 MeV are compared with the calculations based on the statistical model Hauser-Feshbach theory using the spherical optical model transmission coefficients and simple Fermi gas level density formula. The calculations are in good agreement with the recent experimental data, reproducing both the absolute magnitude and the shape exhibited by the excitation function. The results of this comparative study can be used for improving the evaluation of the neutron radiative capture cross section of Th-232. (author)

Determination of the change of nuclear charge radius in the 81 keV transition of {sup 133}Cs by implantation of {sup 133}Xe

Energy Technology Data Exchange (ETDEWEB)

Muramatsu, Hisakazu; Tanaka, Eiji; Ishii, Hiroko [Shinshu Univ., Matsumoto, Nagano (Japan)] [and others

1996-04-01

{sup 133}Cs is a useful probe for studying the binding state of substances with high ionic bond because {sup 133}Cs is only one nuclear species belonging to the alkali elements to make it possible to determine both the Moessbauer effect and the internal conversion electron by the same transition. In this paper, {Delta}R/R (the difference in the nuclear charge radii between the excited state and the ground state of nucleus) in the 81 KeV transition of {sup 133}Cs was determined by the internal conversion method which measured the Moessbauer isomer shift and the strength of internal conversion of the external electron. Al, Zn and Mo are used as the matrices for observation. On Zn and Mo, {Delta}R/R{approx}+0.5x10{sup -4} is derived as the initial value from {rho}4s(0)theor=1344.7 a.u., R=1.2xA{sup 1/3} fm, the isomer shift {delta} and the internal conversion strength ratio (0+P)/N{sub 1} (=({alpha}{sub o}+{alpha}{sub p})/{alpha}N{sub 1}). (S.Y.)

Assessment of tidal range energy resources based on flux conservation in Jiantiao Bay, China

Science.gov (United States)

Du, Min; Wu, He; Yu, Huaming; Lv, Ting; Li, Jiangyu; Yu, Yujun

2017-12-01

La Rance Tidal Range Power Station in France and Jiangxia Tidal Range Power Station in China have been both long-term successful commercialized operations as kind of role models for public at large for more than 40 years. The Sihwa Lake Tidal Range Power Station in South Korea has also developed to be the largest marine renewable power station with its installed capacity 254 MW since 2010. These practical applications prove that the tidal range energy as one kind of marine renewable energy exploitation and utilization technology is becoming more and more mature and it is used more and more widely. However, the assessment of the tidal range energy resources is not well developed nowadays. This paper summarizes the main problems in tidal range power resource assessment, gives a brief introduction to tidal potential energy theory, and then we present an analyzed and estimated method based on the tide numerical modeling. The technical characteristics and applicability of these two approaches are compared with each other. Furthermore, based on the theory of tidal range energy generation combined with flux conservation, this paper proposes a new assessment method that include a series of evaluation parameters and it can be easily operated to calculate the tidal range energy of the sea. Finally, this method is applied on assessment of the tidal range power energy of the Jiantiao Harbor in Zhejiang Province, China for demonstration and examination.

K-shell ionization and double-ionization of Au atoms with 1.33 MeV photons

International Nuclear Information System (INIS)

Belkacem, A.; Dauvergne, D.; Feinberg, B.; Ionescu, D.; Maddi, J.; Sorensen, A.H.

2000-01-01

At relativistic energies, the cross section for the atomic photoelectric effect drops off as does the cross section for liberating any bound electron through Compton scattering. However, when the photon energy exceeds twice the rest mass of the electron, ionization may proceed via electron-positron pair creation. We used 1.33 MeV photons impinging on Au thin foils to study double K-shell ionization and vacuum-assisted photoionization. The preliminary results yield a ratio of vacuum-assisted photoionization and pair creation of 2x10 -3 , a value that is substantially higher than the ratio of photo double ionization to single photoionization that is found to be 0.5-1x10 -4 . Because of the difficulties and large error bars associated with the small cross sections additional measurements are needed to minimize systematic errors

CGC/saturation approach for soft interactions at high energy: long range rapidity correlations

International Nuclear Information System (INIS)

Gotsman, E.; Maor, U.; Levin, E.

2015-01-01

In this paper we continue our program to construct a model for high energy soft interactions that is based on the CGC/saturation approach. The main result of this paper is that we have discovered a mechanism that leads to large long range rapidity correlations and results in large values of the correlation function R(y 1 , y 2 ) ≥ 1, which is independent of y 1 and y 2 . Such a behavior of the correlation function provides strong support for the idea that at high energies the system of partons that is produced is not only dense but also has strong attractive forces acting between the partons. (orig.)

Regional lung function (133Xe-radiospirometry) in bronchial cancer

International Nuclear Information System (INIS)

Arborelius, M.; Kristersson, S.; Lindell, S.E.

1976-01-01

In a prospective study of all patients with bronchial cancer in the city of Malmoe, all patients considered for surgery were examined with regard to overall function (conventional spirometry) and regional lung function (133-Xe-radiospirometry). Out of 116 consecutive cases examined with 133-Xe-radiospirometry before surgery,

Investigation of the 232Th neutron cross-sections in resonance energy range

International Nuclear Information System (INIS)

Grigoriev, Yu.V.; Kitaev, V.Ya.; Sinitsa, V.V.; Zhuravlev, B.V.; Borzakov, S.B.; Faikov-Stanchik, H.; Ilchev, G.L.; Panteleev, Ts.Ts.; Kim, G.N.

2001-01-01

The alternative path in the development of atomic energy is the uranium-thorium cycle. In connection with this, the measurements of the 232 Th neutron capture and total cross-sections and its resonance self-shielding coefficients in resonance energy range are necessary because of their low accuracy. In this work, the results of the investigations of the thorium-232 neutron cross-sections are presented. The measurements have been carried out on the gamma-ray multisection liquid detector and neutron detector as a battery of boron counters on the 120 m flight path of the pulsed fast reactor IBR-30. As the filter samples were used the metallic disks of various thickness and diameter of 45 mm. Two plates from metallic thorium with thickness of 0.2 mm and with the square of 4.5x4.5 cm 2 were used as the radiator samples. The group neutron total and capture cross-sections within the accuracy of 2-7% in the energy range of (10 eV-10 keV) were obtained from the transmissions and the sum spectra of g-rays from the fourth multiplicity to the seventh one. The neutron capture group cross-sections of 238 U were used as the standard for obtaining of thorium ones. Analogous values were calculated on the GRUCON code with the ENDF/B-6, JENDL-3 evaluated data libraries. Within the limits of experimental errors an agreement between the experiment and calculation is observed, but in some groups the experimental values are larger than the calculated ones. (author)

Photoproduction in the Energy Range 70-200 GeV

CERN Multimedia

2002-01-01

This experiment continues the photoproduction studies of WA4 and WA57 up to the higher energies made available by the upgrading of the West Hall. An electron beam of energy 200 GeV is used to produce tagged photons in the range 65-180 GeV; The photon beam is incident on a 60 cm liquid hydrogen target in the Omega Spectrometer. A Ring Image Cherenkov detector provides pion/kaon separation up to 150 GeV/c. The Transition Radiation Detector extends the charged pion identification to the momentum range from about 80 GeV/c upwards. The large lead/liquid scintillator calorimeter built by the WA70 collaboration and the new lead/scintillating fibre det (Plug) are used for the detection of the $\\gamma$ rays produced by the interactions of the primary photons in the hydrogen target. \\\\ \\\\ The aim is to make a survey of photoproduction reactions up to photon energies of 200 GeV. The large aperture of the Omega Spectrometer will particularly enable study of fragmentation of the photon to states of high mass, up to @C 9 G...

Regional cerebral blood flow measurements using noninvasive 133Xe clearance method in children

International Nuclear Information System (INIS)

Nishimoto, Hiroshi; Maeda, Koji; Kagawa, Yukihide; Morozumi, Kunihiko; Hashimoto, Manami; Tsubokawa, Takashi.

1985-01-01

The noninvasive 133-Xe clearance method of estimating rCBF has been widely used in adult clinical studies. It is safe, noninvasive and reproducible, and has provided valuable insight into adult cerebrovascular pathophysiology. However, in children, this technique has not been used to measure rCBF for some fundamental problems. This study was performed to clarify these fundamental problems for applications of noninvasive 133-Xe clearance technique to children. The results showed that three fundamental problems concerning; (1) volume of dead spaces in airway circuits of the system, (2) increasing of look-through phenomenon and (3) correction methods for recirculated 133-Xe and airway artifacts to estimate rCBF are important for applications to children. These problems should be improved to measure as correct rCBF in children as in adults. (author)

7 CFR 1955.133 - Nondiscrimination.

Science.gov (United States)

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.133... for which the Federal financial assistance was extended. (b) Affirmative Fair Housing Marketing Plan...

Exploring the range of energy savings likely from energy efficiency retrofit measures in Ireland's residential sector

International Nuclear Information System (INIS)

Dineen, D.; Ó Gallachóir, B.P.

2017-01-01

This paper estimates the potential energy savings in the Irish residential sector by 2020 due to the introduction of an ambitious retrofit programme. We estimate the technical energy savings potential of retrofit measures targeting energy efficiency of the space and water heating end uses of the 2011 stock of residential dwellings between 2012 and 2020. We build eight separate scenarios, varying the number of dwellings retrofitted and the depth of retrofit carried out in order to investigate the range of energy savings possible. In 2020 the estimated technical savings potential lies in the range from 1713 GWh to 10,817 GWh, but is more likely to fall within the lower end of this range, i.e. between 1700 and 4360 GWh. When rebound effects are taken into account this reduces further to 1100 GWh and 2800 GWh per annum. The purpose of this paper was to test the robustness of the NEEAP target savings for residential retrofit, i.e. 3000 GWh by 2020. We conclude that this target is technically feasible but very challenging and unlikely to be achieved based on progress to date. It will require a significant shift towards deeper retrofit measures compared to what has been achieved by previous schemes. - Highlights: • Paper estimates range of energy savings likely from Irish residential retrofit. • Achieving NEEAP target savings of 3000 GWh by 2020 is feasible but very challenging. • Likely savings of 1100–2800 GWh per annum in 2020, including rebound. • NEEAP target unlikely to be achieved based on current trends.

21 CFR 133.155 - Mozzarella cheese and scamorza cheese.

Science.gov (United States)

2010-04-01

... Section 133.155 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... procedure which produces a finished cheese having the same physical and chemical properties. It may be... culture. One or more of the clotting enzymes specified in paragraph (b)(2) of this section is added to set...

Alpha Beam Energy Determination Using a Range Measuring Device for Radioisotope Production

Energy Technology Data Exchange (ETDEWEB)

Choi, Jun Yong; Kim, Byeon Gil; Hong, Seung Pyo; Kim, Ran Young; Chun, Kwon Soo [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

2016-05-15

The threshold energy of the {sup 209}Bi(α,3n){sup 210} At reaction is at about 30MeV. Our laboratory suggested an energy measurement method to confirm the proton-beam's energy by using a range measurement device. The experiment was performed energy measurement of alpha beam. The alpha beam of energy 29 MeV has been extracted from the cyclotron for the production of {sup 211}At. This device was composed of four parts: an absorber, a drive shaft, and a servo motor and a Faraday cup. The drive shaft was mounted on the absorber and connects with the axis of the servo motor and rotates linearly and circularly by this servo motor. A Faraday cup is for measuring the beam flux. As this drive shaft rotates, the thickness of the absorber varies depending on the rotation angle of the absorber. The energy of the alpha particle accelerated and extracted from MC-50 cyclotron was calculated with the measurement of the particle range in Al foil and using ASTAR, SRIM, MCNPX software. There were a little discrepancy between the expected energy and the calculated energy within the 0.5MeV error range. We have a plan to make an experiment with various alpha particle energies and another methodology, for example, the cross section measurement of the nuclear reaction.

A low background-rate detector for ions in the 5 to 50 keV energy range to be used for radioisotope dating with a small cyclotron

International Nuclear Information System (INIS)

Friedman, P.G.

1986-01-01

Accelerator mass spectrometry in tandem Van de Graaff accelerators has proven successful for radioisotope dating small samples. We are developing a 20 cm diameter 30 to 40 keV cyclotron dedicated to high-sensitivity radioisotope dating, initially for 14 C. At this energy, range and dE/dx methods of particle identification are impossible. Thus arises the difficult problem of reliably detecting 30 to 40 keV 14 C at 10 -2 counts/sec in the high background environment of the cyclotron, where lower energy ions, electrons, and photons bombard the detector at much higher rates. We have developed and tested an inexpensive, generally useful ion detector that allows dark-count rates below 10 -4 counts/sec and excellent background suppression. With the cyclotron tuned near the 13 CH background peak, to the frequency for 14 C, the detector suppresses the background to 6 x 10 -4 counts/sec. For each 14 C ion the detectors grazing-incidence Al 2 O 3 conversion dynode emits about 20 secondary electrons, which are independently multiplied in separate pores of a microchannel plate. The output signal is proportional to the number of secondary electrons, allowing pulse-height discrimination of background. We have successfully tested the detector with positive 12 C, 23 Na, 39 K, 41 K, 85 Rb, 87 Rb, and 133 Cs at 5 to 40 keV, and with 36 keV negative 12 C and 13 CH. It should detect ions and neutrals of all species, at energies above 5 keV, with good efficiency and excellent background discrimination. Counting efficiency and background discrimination improve with higher ion energy. The detector can be operated at least up to 2 x 10 -7 Torr and be repeatedly exposed to air. The maximum rate is 10/sup 6.4/ ions/sec in pulse counting mode and 10/sup 9.7/ ions/sec in current integrating mode

Range-energy relations and stopping powers of organic liquids and vapours for alpha particles

International Nuclear Information System (INIS)

Akhavan-Rezayat, A.; Palmer, R.B.J.

1980-01-01

Experimental range-energy relations are presented for alpha particles in methyl alcohol, propyl alcohol, dichloromethane, chloroform and carbon tetrachloride in both the liquid and vapour phases. Stopping power values for these materials and for oxygen gas over the energy range 1.0-8.0 MeV are also given. From these results stopping powers have been derived for the -CH 2 -group and for -Cl occurring in chemical combination in the liquid and vapour phases. The molecular stopping power in the vapour phase is shown to exceed that in the liquid phase by 2-6% below 2 MeV, reducing to negligible differences at about 5 MeV for the materials directly investigated and for the -Cl atom. No significant phase effect is observed for the -CH 2 -group, but it is noted that the uncertainties in the values of the derived stopping powers are much greater in this case. Comparison of the experimental molecular stopping powers with values calculated from elemental values using the Bragg additivity rule shows agreement for vapours but not for liquids. (author)

CD133 expression is not selective for tumor initiating or radioresistant cell populations in the CRC line HCT-116

International Nuclear Information System (INIS)

Seidel, Claudia; Dietrich, Antje; Wondrak, Marit; Kunz-Schughart, Leoni A.; Grade, Marian; Ried, Thomas

2009-01-01

The hypothesis of certain subpopulations of cancer cells with stem-cell like characteristics that might be responsible for treatment resistance and recurrence of disease is still challenging and under quite controversial discussion. In most studies, surrogate cell surface antigens such as the 92-110 kDa transmembrane glycoprotein CD133 (human Prominin-1) were labeled to isolate particular small cancer cell populations for studying their tumorigenic potential. In colorectal carcinomas (CRC) for example, a small CD133 positive (CD133 + ) cell population has recently been described to be enriched for tumor-initiating/cancer stem cells (TIC/CSC) as compared to the CD133 negative (CD133) population. Furthermore, it was documented that the CD133 + subpopulation could exclusively be maintained in culture as spheres under serum-free conditions. Addition of serum resulted in cell differentiation, growth in 2-D and downregulation of CD133 expression. This would imply that established colorectal cancer (CRC) cell lines that have been grown under adherent, serum-supplemented conditions for years should be devoid of CD133 + cells and TIC/CSC, respectively, which seems contradictory to the finding that many CRC lines produce tumors in nude mice models. In order to gain insight into this paradox, we studied the expression of CD133 in numerous established CRC lines under standard culture conditions and chose one particular cell line based on its expression pattern to study the behavior of CD133 + / CD133 - subpopulations

First quarter 2006: sales up by 13.3% to euros 2,476 million

International Nuclear Information System (INIS)

2006-04-01

The AREVA group's first quarter 2006 sales was euros 2,476 million, compared with euros 2,186 million for the same period in 2005, representing 13.3% growth in terms of reported data. Organic growth was 13.0%. Nuclear operations posted sales of euros 1,660 million, up 11.5% (up 11.6% like-for-like), and buoyant business volume marked by: net growth for the Front End Division (+20.4%), with 60% coming from volume-product mix effects and 40% from favorable price effects, especially for uranium supply and enrichment services; the contribution from the OL3 (Finland), Ling Ao-Phase II (China) and Flamanville 3 EPR (France) reactor projects, which boosted the Reactors and Services Division's sales by 13.2%; a slight decrease in the Back End Division (-2.5%). The Transmission and Distribution Division posted sales of euros 817 million, representing strong organic growth (up 16.6%), consistent with the increase in orders recorded in 2005. Orders booked in the first quarter of 2006 were up by 15.4% like-for-like (up 25.4% in reported data) compared with the first quarter of 2005. For 2006, the Group expects net growth in sales, like-for-like, although not at the particularly high levels of the first quarter

Targeting the Ca2+ Sensor STIM1 by Exosomal Transfer of Ebv-miR-BART13-3p is Associated with Sjögren's Syndrome

Directory of Open Access Journals (Sweden)

Alessia Gallo

2016-08-01

Full Text Available Primary Sjögren's syndrome (pSS is a systemic autoimmune disease that is associated with inflammation and dysfunction of salivary and lacrimal glands. The molecular mechanism(s underlying this exocrinopathy is not known, although the syndrome has been associated with viruses, such as the Epstein Barr Virus (EBV. We report herein that an EBV-specific microRNA (ebv-miR-BART13-3p is significantly elevated in salivary glands (SGs of pSS patients and we show that it targets stromal interacting molecule 1 (STIM1, a primary regulator of the store-operated Ca2+ entry (SOCE pathway that is essential for SG function, leading to loss of SOCE and Ca2+-dependent activation of NFAT. Although EBV typically infects B cells and not salivary epithelial cells, ebv-miR-BART13-3p is present in both cell types in pSS SGs. Importantly, we further demonstrate that ebv-miR-BART13-3p can be transferred from B cells to salivary epithelial cells through exosomes and it recapitulates its functional effects on calcium signaling in a model system.

Symmetry breaking nuclear quadrupole coupling tensor orientation for cesium-133 nuclei located in a mirror plane

Energy Technology Data Exchange (ETDEWEB)

Kim, Tae Ho; Kim, Jin Eun [Dept. of Chemistry (BK21 plus) and Research Institute of Natural Science, Gyeongsang National University, Jinju (Korea, Republic of); Lee, Kang Yeol [School of Mechanical Engineering, Korea University, Seoul (Korea, Republic of)

2016-11-15

Simultaneous multiple data set fits of all transition peaks of {sup 133}Cs nuclei enabled us to obtain accurate cesium-133 nuclear magnetic resonance (NMR) parameters and Euler angles between the principal axis systems of the chemical shift (CS) and quadrupole coupling (Q) tensors of {sup 133}Cs nuclei in Cs{sub 2}CrO{sub 4} . Although in a previous study of Cs{sub 2}CrO{sub 4} by Power et al. (W. P. Power, S. Mooibroek, R. E. Wasylishen, T. S. Cameron, J. Phys. Chem. 1994, 98, 1552), one central transition was observed for cesium sites 1 and 2 in the {sup 133}Cs NMR spectra and one Euler angle between the CS tensors and Q tensors was obtained as 52° and 7° for cesium sites 1 and 2, respectively, the present single-crystal {sup 133}Cs NMR measurements found two Euler angles (10(2)°, 51.9(1)°, 0°) for site 1 and two central transition peaks for site 2. Three principal components of the CS tensor for Cs1 are oriented along the crystallographic a, b, and c axes, whereas none of the principal components of the Q tensor for Cs1 are oriented along the crystal axes. The principal component V{sub 22} of the Q tensor for Cs1 is tilted 10° from the b axis in the bc plane, and the other two components are not located in the ac plane. Therefore, we have found that the requirement that “the quadrupole coupling tensor for a nucleus located in a mirror plane has one principal axis perpendicular to the mirror plane” cannot be applied to Cs1. On the other hand, δ{sub 11} and V{sub 22} for Cs2 are aligned along the b axis, and the other components of the CS and Q tensors deviate at an angle of 1.4(1)° and 10.1(1)°, respectively, from the a and c axes in the ac plane. A distortion-free powder {sup 133}Cs NMR spectrum of Cs{sub 2}CrO{sub 4} was measured using a solid-state spin echo technique.

Physiologic oxygen concentration enhances the stem-like properties of CD133+ human glioblastoma cells in vitro.

Science.gov (United States)

McCord, Amy M; Jamal, Muhammad; Shankavaram, Uma T; Shankavarum, Uma T; Lang, Frederick F; Camphausen, Kevin; Tofilon, Philip J

2009-04-01

In vitro investigations of tumor stem-like cells (TSC) isolated from human glioblastoma (GB) surgical specimens have been done primarily at an atmospheric oxygen level of 20%. To determine whether an oxygen level more consistent with in situ conditions affects their stem cell-like characteristics, we compared GB TSCs grown under conditions of 20% and 7% oxygen. Growing CD133(+) cells sorted from three GB neurosphere cultures at 7% O(2) reduced their doubling time and increased the self-renewal potential as reflected by clonogenicity. Furthermore, at 7% oxygen, the cultures exhibited an enhanced capacity to differentiate along both the glial and neuronal pathways. As compared with 20%, growth at 7% oxygen resulted in an increase in the expression levels of the neural stem cell markers CD133 and nestin as well as the stem cell markers Oct4 and Sox2. In addition, whereas hypoxia inducible factor 1alpha was not affected in CD133(+) TSCs grown at 7% O(2), hypoxia-inducible factor 2alpha was expressed at higher levels as compared with 20% oxygen. Gene expression profiles generated by microarray analysis revealed that reducing oxygen level to 7% resulted in the up-regulation and down-regulation of a significant number of genes, with more than 140 being commonly affected among the three CD133(+) cultures. Furthermore, Gene Ontology categories up-regulated at 7% oxygen included those associated with stem cells or GB TSCs. Thus, the data presented indicate that growth at the more physiologically relevant oxygen level of 7% enhances the stem cell-like phenotype of CD133(+) GB cells.

Occupational exposure to xenon-133 among hospital workers

International Nuclear Information System (INIS)

Deschamps, M.

1984-11-01

During procedures for pulmonary ventilation studies on patients in hospitals, xenon-133 may escape into ambient air. Measurements of air concentrations were required to permit an evaluation of the exposure to which hospital workers are subjected. Two complementary methods of in situ measurements of air concentrations were employed: a commercial air monitor and evacuated blood sampling tubes. Personal dosimeters (TLDs) were exposed simultaneously with the commercial air monitor, and the results were compared. This report presents the results of the measurements of air concentrations during studies on patients. Substantial leakage of xenon-133 was noted, but workers received less than the maximum permissible dose. Personal dosimeters do not permit accurate evaluation of the skin doses resulting from exposure to xenon-133; measurements of air concentrations are required for such evaluation. A number of procedures are recommended to minimize leakage and personnel exposure

Mean range and energy of 28Si ions some Makrofol track detectors

International Nuclear Information System (INIS)

Shyam, S.; Mishra, R.; Tripathy, S.P.; Mawar, A.K.; Dwivedi, K.K.; Khathing, D.T.; Srivastava, A.; Avasthi, D.K.

2000-01-01

The rate of energy loss of the impinging ion as it passes through succeeding layers of the target material gives information regarding the nature of material and helps to calculate the range of the ions in a thick target in which the ions are stopped. Here the range, energy loss of 118 MeV 28 Si were measured in Makrofol-N, Makrofol-G and Makrofol-KG, using nuclear track technique. The experimental range data are compared with the theoretical values obtained from different computer codes. (author)

40 CFR 133.101 - Definitions.

Science.gov (United States)

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS SECONDARY TREATMENT REGULATION § 133.101 Definitions. Terms used in this part are defined as follows: (a) 7-day average. The... pond is used as the principal process, and (3) The treatment works provide significant biological...

Passively-switched energy harvester for increased operational range

International Nuclear Information System (INIS)

Liu, Tian; Livermore, Carol; Pierre, Ryan St

2014-01-01

This paper presents modeling and experimental validation of a new type of vibrational energy harvester that passively switches between two dynamical modes of operation to expand the range of driving frequencies and accelerations over which the harvester effectively extracts power. In both modes, a driving beam with a low resonant frequency couples into ambient vibrations and transfers their energy to a generating beam that has a higher resonant frequency. The generating beam converts the mechanical power into electrical power. In coupled-motion mode, the driving beam bounces off the generating beam. In plucked mode, the driving beam deflects the generating beam until the driving beam passes from above the generating beam to below it or vice versa. Analytical system models are implemented numerically in the time domain for driving frequencies of 3 Hz to 27 Hz and accelerations from 0.1 g to 2.6 g, and both system dynamics and output power are predicted. A corresponding switched-dynamics harvester is tested experimentally, and its voltage, power, and dynamics are recorded. In both models and experiments, coupled-motion harvesting is observed at lower accelerations, whereas plucked harvesting and/or mixed mode harvesting are observed at higher accelerations. As expected, plucked harvesting outputs greater power than coupled-motion harvesting in both simulations and experiments. The predicted (1.8 mW) and measured (1.56 mW) maximum average power levels are similar under measured conditions at 0.5 g. When the system switches to dynamics that are characteristic of higher frequencies, the difference between predicted and measured power levels is more pronounced due to non-ideal mechanical interaction between the beams’ tips. Despite the beams’ non-ideal interactions, switched-dynamics operation increases the harvester’s operating range. (paper)

CGC/saturation approach for soft interactions at high energy: long range rapidity correlations

Energy Technology Data Exchange (ETDEWEB)

Gotsman, E.; Maor, U. [Tel Aviv University, Department of Particle Physics, School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Science, Tel Aviv (Israel); Levin, E. [Tel Aviv University, Department of Particle Physics, School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Science, Tel Aviv (Israel); Universidad Tecnica Federico Santa Maria and Centro Cientifico- Tecnologico de Valparaiso, Departemento de Fisica, Valparaiso (Chile)

2015-11-15

In this paper we continue our program to construct a model for high energy soft interactions that is based on the CGC/saturation approach. The main result of this paper is that we have discovered a mechanism that leads to large long range rapidity correlations and results in large values of the correlation function R(y{sub 1}, y{sub 2}) ≥ 1, which is independent of y{sub 1} and y{sub 2}. Such a behavior of the correlation function provides strong support for the idea that at high energies the system of partons that is produced is not only dense but also has strong attractive forces acting between the partons. (orig.)

Analysis for mass distribution of proton-induced reactions in intermediate energy range

CERN Document Server

Xiao Yu Heng

2002-01-01

The mass and charge distribution of residual products produced in the spallation reactions needs to be studied, because it can provide useful information for the disposal of nuclear waste and residual radioactivity generated by the spallation neutron target system. In present work, the Many State Dynamical Model (MSDM) is based on the Cascade-Exciton Model (CEM). The authors use it to investigate the mass distribution of Nb, Au and Pb proton-induced reactions in energy range from 100 MeV to 3 GeV. The agreement between the MSDM simulations and the measured data is good in this energy range, and deviations mainly show up in the mass range of 90 - 150 for the high energy proton incident upon Au and Pb

Calibration of a large multi-element neutron counter in the energy range 85-430 MeV

CERN Document Server

Strong, J A; Esterling, R J; Garvey, J; Green, M G; Harnew, N; Jane, M R; Jobes, M; Mawson, J; McMahon, T; Robertson, A W; Thomas, D H

1978-01-01

Describes the calibration of a large 60 element neutron counter with a threshold of 2.7 MeV equivalent electron energy. The performance of the counter has been measured in the neutron kinetic energy range 8.5-430 MeV using a neutron beam at the CERN Synchrocyclotron. The results obtained for the efficiency as a function of energy are in reasonable agreement with a Monte Carlo calculation. (7 refs).

Thermal decomposition of 1,3,3-trinitroazetidine (TNAZ): A density functional theory and ab initio study

Energy Technology Data Exchange (ETDEWEB)

Veals, Jeffrey D.; Thompson, Donald L. [Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211 (United States)

2014-04-21

Density functional theory and ab initio methods are employed to investigate decomposition pathways of 1,3,3-trinitroazetidine initiated by unimolecular loss of NO{sub 2} or HONO. Geometry optimizations are performed using M06/cc-pVTZ and coupled-cluster (CC) theory with single, double, and perturbative triple excitations, CCSD(T), is used to calculate accurate single-point energies for those geometries. The CCSD(T)/cc-pVTZ energies for NO{sub 2} elimination by N–N and C–N bond fission are, including zero-point energy (ZPE) corrections, 43.21 kcal/mol and 50.46 kcal/mol, respectively. The decomposition initiated by trans-HONO elimination can occur by a concerted H-atom and nitramine NO{sub 2} group elimination or by a concerted H-atom and nitroalkyl NO{sub 2} group elimination via barriers (at the CCSD(T)/cc-pVTZ level with ZPE corrections) of 47.00 kcal/mol and 48.27 kcal/mol, respectively. Thus, at the CCSD(T)/cc-pVTZ level, the ordering of these four decomposition steps from energetically most favored to least favored is: NO{sub 2} elimination by N–N bond fission, HONO elimination involving the nitramine NO{sub 2} group, HONO elimination involving a nitroalkyl NO{sub 2} group, and finally NO{sub 2} elimination by C–N bond fission.

SU-G-TeP1-02: Analytical Stopping Power and Range Parameterization for Therapeutic Energy Intervals

Energy Technology Data Exchange (ETDEWEB)

Donahue, W [Louisiana State University, Baton Rouge, LA (United States); Newhauser, W [Louisiana State University, Baton Rouge, LA (United States); Mary Bird Perkins Cancer Center, Baton Rouge, LA (United States); Ziegler, J F [United States Naval Academy, Annapolis, MD (United States)

2016-06-15

Purpose: To develop a simple, analytic parameterization of stopping power and range, which covers a wide energy interval and is applicable to many species of projectile ions and target materials, with less than 15% disagreement in linear stopping power and 1 mm in range. Methods: The new parameterization was required to be analytically integrable from stopping power to range, and continuous across the range interval of 1 µm to 50 cm. The model parameters were determined from stopping power and range data for hydrogen, carbon, iron, and uranium ions incident on water, carbon, aluminum, lead and copper. Stopping power and range data was taken from SRIM. A stochastic minimization algorithm was used to find model parameters, with 10 data points per energy decade. Additionally, fitting was performed with 2 and 26 data points per energy decade to test the model’s robustness to sparse Results: 6 free parameters were sufficient to cover the therapeutic energy range for each projectile ion species (e.g. 1 keV – 300 MeV for protons). The model agrees with stopping power and range data well, with less than 9% relative stopping power difference and 0.5 mm difference in range. As few as, 4 bins per decade were required to achieve comparable fitting results to the full data set. Conclusion: This study successfully demonstrated that a simple analytic function can be used to fit the entire energy interval of therapeutic ion beams of hydrogen and heavier elements. Advantages of this model were the small number (6) of free parameters, and that the model calculates both stopping power and range. Applications of this model include GPU-based dose calculation algorithms and Monte Carlo simulations, where available memory is limited. This work was supported in part by a research agreement between United States Naval Academy and Louisiana State University: Contract No N00189-13-P-0786. In addition, this work was accepted for presentation at the American Nuclear Society Annual Meeting

SU-G-TeP1-02: Analytical Stopping Power and Range Parameterization for Therapeutic Energy Intervals

International Nuclear Information System (INIS)

Donahue, W; Newhauser, W; Ziegler, J F

2016-01-01

Purpose: To develop a simple, analytic parameterization of stopping power and range, which covers a wide energy interval and is applicable to many species of projectile ions and target materials, with less than 15% disagreement in linear stopping power and 1 mm in range. Methods: The new parameterization was required to be analytically integrable from stopping power to range, and continuous across the range interval of 1 µm to 50 cm. The model parameters were determined from stopping power and range data for hydrogen, carbon, iron, and uranium ions incident on water, carbon, aluminum, lead and copper. Stopping power and range data was taken from SRIM. A stochastic minimization algorithm was used to find model parameters, with 10 data points per energy decade. Additionally, fitting was performed with 2 and 26 data points per energy decade to test the model’s robustness to sparse Results: 6 free parameters were sufficient to cover the therapeutic energy range for each projectile ion species (e.g. 1 keV – 300 MeV for protons). The model agrees with stopping power and range data well, with less than 9% relative stopping power difference and 0.5 mm difference in range. As few as, 4 bins per decade were required to achieve comparable fitting results to the full data set. Conclusion: This study successfully demonstrated that a simple analytic function can be used to fit the entire energy interval of therapeutic ion beams of hydrogen and heavier elements. Advantages of this model were the small number (6) of free parameters, and that the model calculates both stopping power and range. Applications of this model include GPU-based dose calculation algorithms and Monte Carlo simulations, where available memory is limited. This work was supported in part by a research agreement between United States Naval Academy and Louisiana State University: Contract No N00189-13-P-0786. In addition, this work was accepted for presentation at the American Nuclear Society Annual Meeting

Transport properties of gaseous ions over a wide energy range, IV

International Nuclear Information System (INIS)

Viehland, L.A.; Mason, E.A.

1995-01-01

This paper updates three previous papers entitled open-quotes Transport Properties of Gaseous Ions over a Wide Energy Range.close quotes. These papers referred to as Parts I, II, and III, were by H.W.Ellis, P.Y. Pai, E.W. McDaniel, E.A. Mason, and L.A. Viehland, S.L. Lin, M.G. Thackston. Part IV contains compilations of experimental data on ionic mobilities and diffusion coefficients (both longitudinal and transverse) for ions in neutral gases in an externally applied electrostatic field, at various gas temperatures; the data are tabulated as a function of the ionic energy parameter E/N, where E is the electric field strength and N is the number density of the neutral gas. Part IV also contains a locator key to ionic mobilities and diffusion coefficients compiled in Parts I-IV. The coverage of the literature extends into 1994. The criteria for selection of the data are; (1) the measurements must cover a reasonably wide range of E/N; (2) the identity of the ions must be well established; and (3) the accuracy of the data must be good. 26 refs., 6 tabs

36 CFR 223.133 - Definitions.

Science.gov (United States)

2010-07-01

... 223.133 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND... from Forest Service timber sale contracts for a reasonable, specified period of time. A purchaser so... evidence means proof by information that, compared with that opposing it, leads to the conclusion that the...

46 CFR 56.01-3 - Power boilers, external piping and appurtenances (Replaces 100.1.1, 100.1.2, 122.1, 132 and 133).

Science.gov (United States)

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Power boilers, external piping and appurtenances... boilers, external piping and appurtenances (Replaces 100.1.1, 100.1.2, 122.1, 132 and 133). (a) Power boiler external piping and components must meet the requirements of this part and §§ 52.01-105, 52.01-110...

Photoabsorption and S 2p photoionization of the SF6 molecule: resonances in the excitation energy range of 200-280 eV.

Science.gov (United States)

Stener, M; Bolognesi, P; Coreno, M; O'Keeffe, P; Feyer, V; Fronzoni, G; Decleva, P; Avaldi, L; Kivimäki, A

2011-05-07

Photoabsorption and S 2p photoionization of the SF(6) molecule have been studied experimentally and theoretically in the excitation energy range up to 100 eV above the S 2p ionization potentials. In addition to the well-known 2t(2g) and 4e(g) shape resonances, the spin-orbit-resolved S 2p photoionization cross sections display two weak resonances between 200 and 210 eV, a wide resonance around 217 eV, a Fano-type resonance around 240 eV, and a second wide resonance around 260 eV. Calculations based on time-dependent density functional theory allow us to assign the 217-eV and 260-eV features to the shape resonances in S 2p photoionization. The Fano resonance is caused by the interference between the direct S 2p photoionization channel and the resonant channel that results from the participator decay of the S 2s(-1)6t(1u) excited state. The weak resonances below 210-eV photon energy, not predicted by theory, are tentatively suggested to originate from the coupling between S 2p shake-up photoionization and S 2p single-hole photoionization. The experimental and calculated angular anisotropy parameters for S 2p photoionization are in good agreement.

Cerebral blood flow (CBF) with 133Xe inhalation method

International Nuclear Information System (INIS)

Kusunoki, Tadaki; Masumura, Michio; Tamaki, Norihiko; Matsumoto, Satoshi; Yamashita, Hideyuki.

1982-01-01

The effects of CO 2 inhalation on the cerebral blood flow (CBF) were examined with 133 Xe inhalation method (Novo Inhalation Cerebrograph) on 9 normal peoples and 20 patients. Nine normal peoples were divided into 3 groups consisting of each 3 peoples, namely young age group, middle age group, and old age group. Each increased CBF (%) by CO 2 inhalation was 40 -- 44 in young age group, 36 -- 37 in middle age group, and 35 -- 36 in old age group in the blood flow of the first compartment (F 1 ), and 27 -- 28 in young age group, 30 -- 31 in middle age group and 23 -- 24 in old age group in the initial slope index (ISI). Each CO 2 reactivity factor (RF) was 5.5 -- 5.8 in young age group, 3.8 -- 4.0 in middle age group and 3.3 in old age group in F 1 , and 3.1 -- 3.2 in young age group, 2.0 -- 3.3 in middle age group, and 1.2 -- 1.3 in old age group in ISI. Twenty patients consisted of 15 patients of occlusive cerebrovascular disease, 2 patients of head injury, 2 patients of normal pressure hydrocephalus and one patient of subarachnoid hemorrhage. RF was abnormally lower than normal value in 5 patients in F 1 , but in 7 in ISI. Clinical benefits of CBF study during CO 2 inhalation with 133 Xe inhalation method were discussed. (author)

Alternative separation of exchange and correlation energies in range-separated density-functional perturbation theory

DEFF Research Database (Denmark)

Cornaton, Y.; Stoyanova, A.; Jensen, Hans Jørgen Aagaard

2013-01-01

of the noninteracting Kohn-Sham one. When second-order corrections to the density are neglected, the energy expression reduces to a range-separated double-hybrid (RSDH) type of functional, RSDHf, where "f" stands for "full-range integrals" as the regular full-range interaction appears explicitly in the energy...

Immunocapture of CD133-positive cells from human cancer cell lines by using monodisperse magnetic poly(glycidyl methacrylate) microspheres containing amino groups

Energy Technology Data Exchange (ETDEWEB)

Kuan, Wei-Chih [Department of Chemical Engineering, Systems Biology and Tissue Engineering Research Center, National Chung Cheng University, Minhisung 621, Taiwan (China); Horák, Daniel, E-mail: horak@imc.cas.cz [Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6 (Czech Republic); Plichta, Zdeněk [Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6 (Czech Republic); Lee, Wen-Chien [Department of Chemical Engineering, Systems Biology and Tissue Engineering Research Center, National Chung Cheng University, Minhisung 621, Taiwan (China)

2014-01-01

Magnetic poly(glycidyl methacrylate)-based macroporous microspheres with an average particle size of 4.2 μm were prepared using a modified multi-step swelling polymerization method and by introducing amino functionality on their surfaces. Antibody molecules were oxidized on their carbohydrate moieties and bound to the amino-containing magnetic microspheres via a site-directed procedure. CD133-positive cells could be effectively captured from human cancer cell lines (HepG2, HCT116, MCF7, and IMR-32) by using magnetic microspheres conjugated to an anti-human CD133 antibody. After further culture, the immunocaptured CD133-expressing cells from IMR-32 proliferated and gradually detached from the magnetic microspheres. Flow-cytometric analysis confirmed the enrichment of CD133-expressing cells by using the antibody-bound magnetic microspheres. Such microspheres suitable for immunocapture are very promising for cancer diagnosis because the CD133-expressing cells in cancer cell lines have been suggested to be cancer stem cells. - Highlights: • Multi-step swelling polymerization produced poly(glycidyl methacrylate) microspheres. • Anti-human CD133 antibodies were bound to the amino-containing magnetic microspheres. • CD133-positive cells were effectively captured from human cancer cell lines. • Immunocaptured CD133-expressing cells proliferated and were detached from microspheres. • Enrichment of CD133-expressing cells was confirmed by flow-cytometric analysis.

CMOS Active Pixel Sensors as energy-range detectors for proton Computed Tomography

International Nuclear Information System (INIS)

Esposito, M.; Waltham, C.; Allinson, N.M.; Anaxagoras, T.; Evans, P.M.; Poludniowski, G.; Green, S.; Parker, D.J.; Price, T.; Manolopoulos, S.; Nieto-Camero, J.

2015-01-01

Since the first proof of concept in the early 70s, a number of technologies has been proposed to perform proton CT (pCT), as a means of mapping tissue stopping power for accurate treatment planning in proton therapy. Previous prototypes of energy-range detectors for pCT have been mainly based on the use of scintillator-based calorimeters, to measure proton residual energy after passing through the patient. However, such an approach is limited by the need for only a single proton passing through the energy-range detector in a read-out cycle. A novel approach to this problem could be the use of pixelated detectors, where the independent read-out of each pixel allows to measure simultaneously the residual energy of a number of protons in the same read-out cycle, facilitating a faster and more efficient pCT scan. This paper investigates the suitability of CMOS Active Pixel Sensors (APSs) to track individual protons as they go through a number of CMOS layers, forming an energy-range telescope. Measurements performed at the iThemba Laboratories will be presented and analysed in terms of correlation, to confirm capability of proton tracking for CMOS APSs

CMOS Active Pixel Sensors as energy-range detectors for proton Computed Tomography.

Science.gov (United States)

Esposito, M; Anaxagoras, T; Evans, P M; Green, S; Manolopoulos, S; Nieto-Camero, J; Parker, D J; Poludniowski, G; Price, T; Waltham, C; Allinson, N M

2015-06-03

Since the first proof of concept in the early 70s, a number of technologies has been proposed to perform proton CT (pCT), as a means of mapping tissue stopping power for accurate treatment planning in proton therapy. Previous prototypes of energy-range detectors for pCT have been mainly based on the use of scintillator-based calorimeters, to measure proton residual energy after passing through the patient. However, such an approach is limited by the need for only a single proton passing through the energy-range detector in a read-out cycle. A novel approach to this problem could be the use of pixelated detectors, where the independent read-out of each pixel allows to measure simultaneously the residual energy of a number of protons in the same read-out cycle, facilitating a faster and more efficient pCT scan. This paper investigates the suitability of CMOS Active Pixel Sensors (APSs) to track individual protons as they go through a number of CMOS layers, forming an energy-range telescope. Measurements performed at the iThemba Laboratories will be presented and analysed in terms of correlation, to confirm capability of proton tracking for CMOS APSs.

33 CFR 133.5 - Requests: General.

Science.gov (United States)

2010-07-01

... POLLUTION FINANCIAL RESPONSIBILITY AND COMPENSATION OIL SPILL LIABILITY TRUST FUND; STATE ACCESS § 133.5...) and 49 CFR parts 18, 20, 29, and 90 apply to Fund monies obligated for payment under this part. ...

46 CFR 133.110 - Survival craft muster and embarkation arrangements.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Survival craft muster and embarkation arrangements. 133... VESSELS LIFESAVING SYSTEMS Requirements for All OSVs § 133.110 Survival craft muster and embarkation... lighting supplied from the emergency source of electrical power. (e) Each davit-launched survival craft...

Distance Support In-Service Engineering for the High Energy Laser

Science.gov (United States)

2015-03-01

FEL only) o Isoplanatic angle (if available) o Fried coherence length o Object distance o Dwell time o Laser spot size While many of the items...system and the HEL system. Acquisition Sensor Laser Subsystem Beam Shaping Sensor Suile . Range Finder -. Coarse Tracker . Fine Tracker Optical...distribution is unlimited DISTANCE SUPPORT IN-SERVICE ENGINEERING FOR THE HIGH ENERGY LASER by Team Raising HEL from a Distance Cohort 311-133O March

21 CFR 133.136 - Washed curd and soaked curd cheese.

Science.gov (United States)

2010-04-01

... Section 133.136 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... this section or by any other procedure which produces a finished cheese having the same physical and... bacterial culture. One or more of the clotting enzymes specified in paragraph (b)(2) of this section is...

Mass energy-absorption coefficients and average atomic energy-absorption cross-sections for amino acids in the energy range 0.122-1.330 MeV

Energy Technology Data Exchange (ETDEWEB)

More, Chaitali V., E-mail: chaitalimore89@gmail.com; Lokhande, Rajkumar M.; Pawar, Pravina P., E-mail: pravinapawar4@gmail.com [Department of physics, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004 (India)

2016-05-06

Mass attenuation coefficients of amino acids such as n-acetyl-l-tryptophan, n-acetyl-l-tyrosine and d-tryptophan were measured in the energy range 0.122-1.330 MeV. NaI (Tl) scintillation detection system was used to detect gamma rays with a resolution of 8.2% at 0.662 MeV. The measured attenuation coefficient values were then used to determine the mass energy-absorption coefficients (σ{sub a,en}) and average atomic energy-absorption cross sections (μ{sub en}/ρ) of the amino acids. Theoretical values were calculated based on XCOM data. Theoretical and experimental values are found to be in good agreement.

4.5 Tesla magnetic field reduces range of high-energy positrons -- Potential implications for positron emission tomography

International Nuclear Information System (INIS)

Wirrwar, A.; Vosberg, H.; Herzog, H.; Halling, H.; Weber, S.; Mueller-Gaertner, H.W.; Forschungszentrum Juelich GmbH

1997-01-01

The authors have theoretically and experimentally investigated the extent to which homogeneous magnetic fields up to 7 Tesla reduce the spatial distance positrons travel before annihilation (positron range). Computer simulations of a noncoincident detector design using a Monte Carlo algorithm calculated the positron range as a function of positron energy and magnetic field strength. The simulation predicted improvements in resolution, defined as full-width at half-maximum (FWHM) of the line-spread function (LSF) for a magnetic field strength up to 7 Tesla: negligible for F-18, from 3.35 mm to 2.73 mm for Ga-68 and from 3.66 mm to 2.68 mm for Rb-82. Also a substantial noise suppression was observed, described by the full-width at tenth-maximum (FWTM) for higher positron energies. The experimental approach confirmed an improvement in resolution for Ga-68 from 3.54 mm at 0 Tesla to 2.99 mm FWHM at 4.5 Tesla and practically no improvement for F-18 (2.97 mm at 0 Tesla and 2.95 mm at 4.5 Tesla). It is concluded that the simulation model is appropriate and that a homogeneous static magnetic field of 4.5 Tesla reduces the range of high-energy positrons to an extent that may improve spatial resolution in positron emission tomography

TAp63 suppress metastasis via miR-133b in colon cancer cells.

Science.gov (United States)

Lin, C W; Li, X R; Zhang, Y; Hu, G; Guo, Y H; Zhou, J Y; Du, J; Lv, L; Gao, K; Zhang, Y; Deng, H

2014-04-29

TAp63 is a tumour-suppressor protein that is often underexpressed in various types of cancer. It has been shown to activate gene transcription depending on the transcription domain and to be closely related with metastasis. In this study, we demonstrate that TAp63 suppresses metastasis in colon cancer cells through microRNA-133b. We evaluated the correlation of TAp63 and miR-133b with HT-29 and SW-620 cells and investigated the roles of TAp63 in the expression of RhoA, E-cadherin and vimentin. We further investigated the roles of TAp63-mediated invasion and migration of colon cancer cells. TAp63 expression is downregulated in colon cancer, and microRNA-133b is a transcriptional target of TAp63. Furthermore, microRNA-133b is essential for the inhibitory effects of TAp63 on RhoA, E-cadherin and vimentin. Moreover, TAp63 inhibits cell migration and invasion through microRNA-133b. Correspondingly, the inhibitory effect of TAp63 on RhoA, E-cadherin, vimentin, migration and invasion can be blocked by the microRNA-133b inhibitor. TAp63 and microRNA-133b were able to suppress the metastasis of colon cancer. Both TAp63 and microRNA-133b may be potential biomarkers for diagnosis in colon cancer metastasis and may provide unique therapeutic targets for this common malignancy.

MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells

International Nuclear Information System (INIS)

Zhao, Yu; Zhu, Zhenggang; Huang, Jie; Zhang, Li; Qu, Ying; Li, Jianfang; Yu, Beiqin; Yan, Min; Yu, Yingyan; Liu, Bingya

2014-01-01

Emerging evidence has shown that microRNAs are involved in gastric cancer development and progression. Here we examine the role of miR-133b in gastric cancer. Quantitative real-time PCR analysis was performed in 140 patient gastric cancer tissues and 8 gastric cancer cell lines. The effects of miR-133b in gastric cancer cells metastasis were examined by scratch assay, transwell migration and matrigel invasion. In vivo effects of miR-133b were examined in an intraperitoneal mouse tumor model. Targets of miR-133b were predicted by bioinformatics tools and validated by luciferase reporter analyses, western blot, and quantitative real-time PCR. MiR-133b was significantly downregulated in 70% (98/140) of gastric cancer patients. Expression of miR-133b was negatively correlated with lymph node metastasis of gastric cancer in patients. Similarly, the expression of miR-133b was significantly lower in seven tested gastric cancer cell lines than in the immortalized non-cancerous GES-1 gastric epithelial cells. Overexpression of miR-133b markedly inhibited metastasis of gastric cancer cells in vitro and in vivo. Moreover, the transcriptional factor Gli1 was identified as a direct target for miR-133b. Level of Gli1 protein but not mRNA was decreased by miR-133b. Activity of luciferase with Gli1 3′-untranslated region was markedly decreased by miR-133b in gastric cancer cells. Gli1 target genes, OPN and Zeb2, were also inhibited by miR133b. MiR-133b is frequently decreased in gastric cancer. Overexpression of miR-133b inhibits cell metastasis in vitro and in vivo partly by directly suppressing expression of Gli1 protein. These results suggested that miR-133b plays an important role in gastric cancer metastasis

DDX4 (DEAD box polypeptide 4) colocalizes with cancer stem cell marker CD133 in ovarian cancers

International Nuclear Information System (INIS)

Kim, Ki Hyung; Kang, Yun-Jeong; Jo, Jin-Ok; Ock, Mee Sun; Moon, Soo Hyun; Suh, Dong Soo; Yoon, Man Soo; Park, Eun-Sil; Jeong, Namkung; Eo, Wan-Kyu; Kim, Heung Yeol; Cha, Hee-Jae

2014-01-01

Highlights: • Germ cell marker DDX4 was significantly increased in ovarian cancer. • Ovarian cancer stem cell marker CD133 was significantly increased in ovarian cancer. • DDX4 and CD133 were mostly colocalized in various types of ovarian cancer tissues. • CD133 positive ovarian cancer cells also express DDX4 whereas CD133-negative cells did not possess DDX4. • Germ cell marker DDX4 has the potential of ovarian cancer stem cell marker. - Abstract: DDX4 (DEAD box polypeptide 4), characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), is an RNA helicase which is implicated in various cellular processes involving the alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. DDX4 is known to be a germ cell-specific protein and is used as a sorting marker of germline stem cells for the production of oocytes. A recent report about DDX4 in ovarian cancer showed that DDX4 is overexpressed in epithelial ovarian cancer and disrupts a DNA damage-induced G2 checkpoint. We investigated the relationship between DDX4 and ovarian cancer stem cells by analyzing the expression patterns of DDX4 and the cancer stem cell marker CD133 in ovarian cancers via tissue microarray. Both DDX4 and CD133 were significantly increased in ovarian cancer compared to benign tumors, and showed similar patterns of expression. In addition, DDX4 and CD133 were mostly colocalized in various types of ovarian cancer tissues. Furthermore, almost all CD133 positive ovarian cancer cells also express DDX4 whereas CD133-negative cells did not possess DDX4, suggesting a strong possibility that DDX4 plays an important role in cancer stem cells, and/or can be used as an ovarian cancer stem cell marker

Total photoabsorption cross section on nuclei measured in energy range 0.5-2.6 GeV; Misura della sezione d`urto di fotoassorbimento tra 0.5 e 2.6 GeV su nuclei ed analisi dei dati

Energy Technology Data Exchange (ETDEWEB)

Mirazita, M. [INFN, Laboratori Nazionali di Frascati, Rome (Italy)

1998-03-01

The total photoabsorption cross section on several nuclei has been measured in the energy range 0.5 - 2.6 GeV. Nuclear data show a significant reduction of the absorption strength with respect to the free nucleon case suggesting a shadowing effect at low energies.

In vitro identification and characterization of CD133(pos cancer stem-like cells in anaplastic thyroid carcinoma cell lines.

Directory of Open Access Journals (Sweden)

Giovanni Zito

Full Text Available Recent publications suggest that neoplastic initiation and growth are dependent on a small subset of cells, termed cancer stem cells (CSCs. Anaplastic Thyroid Carcinoma (ATC is a very aggressive solid tumor with poor prognosis, characterized by high dedifferentiation. The existence of CSCs might account for the heterogeneity of ATC lesions. CD133 has been identified as a stem cell marker for normal and cancerous tissues, although its biological function remains unknown.ATC cell lines ARO, KAT-4, KAT-18 and FRO were analyzed for CD133 expression. Flow cytometry showed CD133(pos cells only in ARO and KAT-4 (64+/-9% and 57+/-12%, respectively. These data were confirmed by qRT-PCR and immunocytochemistry. ARO and KAT-4 were also positive for fetal marker oncofetal fibronectin and negative for thyrocyte-specific differentiating markers thyroglobulin, thyroperoxidase and sodium/iodide symporter. Sorted ARO/CD133(pos cells exhibited higher proliferation, self-renewal, colony-forming ability in comparison with ARO/CD133(neg. Furthermore, ARO/CD133(pos showed levels of thyroid transcription factor TTF-1 similar to the fetal thyroid cell line TAD-2, while the expression in ARO/CD133(neg was negligible. The expression of the stem cell marker OCT-4 detected by RT-PCR and flow cytometry was markedly higher in ARO/CD133(pos in comparison to ARO/CD133(neg cells. The stem cell markers c-KIT and THY-1 were negative. Sensitivity to chemotherapy agents was investigated, showing remarkable resistance to chemotherapy-induced apoptosis in ARO/CD133(pos when compared with ARO/CD133(neg cells.We describe CD133(pos cells in ATC cell lines. ARO/CD133(pos cells exhibit stem cell-like features--such as high proliferation, self-renewal ability, expression of OCT-4--and are characterized by higher resistance to chemotherapy. The simultaneous positivity for thyroid specific factor TTF-1 and onfFN suggest they might represent putative thyroid cancer stem-like cells. Our in

[Regional liver circulation and scintigraphic imaging of portal circulation with 133Xe].

Science.gov (United States)

Kroiss, A

1984-01-01

Regional hepatic blood flow has been determined by 4 methods with the aid of the 133Xe washout technique: scintisplenoportography (direct application of 133Xe into the spleen by means of a thin needle); arterial method (133Xe is injected into the A. hepatica by means of a catheter); retrograde-venous method (133Xe administered by an occluding hepatic vein catheter); percutaneous intrahepatic method (133Xe administered directly into the parenchyma by means of a Chiba needle). Ad 1.: Scintisplenoportography (SSP) was executed with 97 patients: 8 patients with a healthy liver presented a hepatic blood flow of 103.37 +/- 11.5 ml/100 g/min. 4 patients with a chronic hepatitis showed a hepatic blood flow of 105.67 +/- 10.2 ml/100 g/min. In 38 patients with compensated cirrhosis, hepatic blood flow was determined with 58.15 +/- 11.5 ml/100 g/min and 19 patients with decompensated cirrhosis showed a blood flow of 34.54 +/- 7.2 ml/100 g/min. Of the 19 patients, who did not present any liver image, 2 patients suffered from a prehepatic block, 1 patient (female) from a posthepatic block, the rest were decompensated cirrhoses. In 5 patients suffering from steatosis only collateral circulation was determined and in 4 patients the spleen could not be punctured. In the patients with compensated and decompensated cirrhosis of the liver, hepatic blood flow differentiated significantly (p less than 0.001) from patients with healthy livers and chronic hepatitis. In the patients with bioptically assured steatosis only the washout constant was determined. Reproducibility of this method was tested in 4 patients and no statistical difference of hepatic blood flow values could be found and the correlation coefficient amounted to 0.9856. The advantage of SSP lies in the possibility of recording the portal vein circulation: cranial collaterals were found in 33 patients, 2 patients had caudal collaterals exclusively and 29 patients cranial and caudal collaterals. 33 cirrhosis patients

Ventilation abnormalities in obstructive airways disorder. Detection with pulmonary dynamic densitometry by means of spinal CT versus dynamic Xe-133 SPECT

International Nuclear Information System (INIS)

Suga, Kazuyoshi; Nishigauchi, Kazuya; Kume, Norihiko; Takana, Katsuyuki; Koike, Shinji; Shimizu, Kensaku; Matsunaga, Naofumi

1999-01-01

The usefulness of pulmonary dynamic densitometry (PDD) acquired by spiral computed tomography (CT) to detect ventilation abnormalities in obstructive airway disorders was evaluated in comparison with dynamic xenon-133 (Xe-133) SPECT. Eight-second, continuous spiral CT scan was performed over 2-3 respiratory cycles in six healthy volunteers, 19 patients with airways disorder, and six patients with restrictive lung disease. The data set were reconstructed as 36 one-second temporally overlapping images at 0.2-second intervals, and regional PDD curves were displayed. Regional ventilation was assessed by Xe-133 clearance-time on Xe-133 SPECT. Normal lungs showed smooth, sinusoidal PDD curves with maximal amplitude in lung attenuation change (MALAC) of 54.9+24.5 HU; whereas, obstructive airways disorders with prolonged Xe-133 clearance showed significantly diminished MALAC (31.6+20.1 HU, P<0.0001), accompanied by irregularity, asynchronous phase, and deterioration of normal ventral-to-dorsal gradients in MALAC and lung attenuation. Restrictive diseases without prolonged Xe-133 clearance did not show statistically significant reduction in MALAC. In total 251 lung regions, regional MALAC correlated inversely with Xe-133 clearance-time (r=842). PDD acquired by spiral CT is acceptable for detecting ventilation abnormalities in obstructive airways disorder. (author)

19 CFR 133.51 - Relief from forfeiture or liquidated damages.

Science.gov (United States)

2010-04-01

... following conditions and such other conditions as may be specified by the appropriate Customs authority: (1... 19 Customs Duties 1 2010-04-01 2010-04-01 false Relief from forfeiture or liquidated damages. 133.51 Section 133.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY...

21 CFR 133.156 - Low-moisture mozzarella and scamorza cheese.

Science.gov (United States)

2010-04-01

....156 Section 133.156 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... this section, or by any other procedure which produces a finished cheese having the same physical and... bacterial culture. One or more of the clotting enzymes specified in paragraph (b)(2) of this action is added...

Relationship of 133Xe cerebral blood flow to middle cerebral arterial flow velocity in men at rest

Science.gov (United States)

Clark, J. M.; Skolnick, B. E.; Gelfand, R.; Farber, R. E.; Stierheim, M.; Stevens, W. C.; Beck, G. Jr; Lambertsen, C. J.

1996-01-01

Cerebral blood flow (CBF) was measured by 133Xe clearance simultaneously with the velocity of blood flow through the left middle cerebral artery (MCA) over a wide range of arterial PCO2 in eight normal men. Average arterial PCO2, which was varied by giving 4% and 6% CO2 in O2 and by controlled hyperventilation on O2, ranged from 25.3 to 49.9 mm Hg. Corresponding average values of global CBF15 were 27.2 and 65.0 ml 100 g min-1, respectively, whereas MCA blood-flow velocity ranged from 42.8 to 94.2 cm/s. The relationship of CBF to MCA blood-flow velocity over the imposed range of arterial PCO2 was described analytically by a parabola with the equation: CBF = 22.8 - 0.17 x velocity + 0.006 x velocity2 The observed data indicate that MCA blood-flow velocity is a useful index of CBF response to change in arterial PCO2 during O2 breathing at rest. With respect to baseline values measured while breathing 100% O2 spontaneously, percent changes in velocity were significantly smaller than corresponding percent changes in CBF at increased levels of arterial PCO2 and larger than CBF changes at the lower arterial PCO2. These observed relative changes are consistent with MCA vasodilation at the site of measurement during exposure to progressive hypercapnia and also during extreme hyperventilation hypocapnia.

15q13.3 microdeletions increase risk of idiopathic generalized epilepsy

DEFF Research Database (Denmark)

Helbig, Ingo; Mefford, Heather C; Sharp, Andrew J

2009-01-01

We identified 15q13.3 microdeletions encompassing the CHRNA7 gene in 12 of 1,223 individuals with idiopathic generalized epilepsy (IGE), which were not detected in 3,699 controls (joint P = 5.32 x 10(-8)). Most deletion carriers showed common IGE syndromes without other features previously...... associated with 15q13.3 microdeletions, such as intellectual disability, autism or schizophrenia. Our results indicate that 15q13.3 microdeletions constitute the most prevalent risk factor for common epilepsies identified to date....

Activation of the sonic hedgehog signaling pathway occurs in the CD133 positive cells of mouse liver cancer Hepa 1–6 cells

Directory of Open Access Journals (Sweden)

Jeng KS

2013-08-01

Full Text Available Kuo-Shyang Jeng,1 I-Shyan Sheen,2 Wen-Juei Jeng,2 Ming-Che Yu,3 Hsin-I Hsiau,3 Fang-Yu Chang,3 Hsin-Hua Tsai31Department of Surgery, Far Eastern Memorial Hospital, Taipei, 2Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, 3Department of Medical Research, Far Eastern Memorial Hospital, Taipei, Taiwan, Republic of ChinaBackground: The important role of cancer stem cells in carcinogenesis has been emphasized in research. CD133+ cells have been mentioned as liver cancer stem cells in hepatocellular carcinoma (HCC. Some researchers have proposed that the sonic hedgehog (Shh pathway contributes to hepatocarcinogenesis and that the pathway activation occurs mainly in cancer stem cells. We investigated whether the activation of the Shh pathway occurs in CD133+ cells from liver cancer.Materials and methods: We used magnetic sorting to isolate CD133+ cells from mouse cancer Hepa 1–6 cells. To examine the clonogenicity, cell culture and soft agar colony formation assay were performed between CD133+ and CD133- cells. To study the activation of the Shh pathway, we examined the mRNA expressions of Shh, patched homolog 1 (Ptch-1, glioma-associated oncogene homolog 1 (Gli-1, and smoothened homolog (Smoh by real-time polymerase chain reaction of both CD133+ and CD133- cells.Results: The number (mean ± standard deviation of colonies of CD133+ cells and CD133- cells was 1,031.0 ± 104.7 and 119.7 ± 17.6 respectively. This difference was statistically significant (P < 0.001. Their clonogenicity was 13.7% ± 1.4% and 1.6% ± 0.2% respectively with a statistically significant difference found (P < 0.001. CD133+ cells and CD133– cells were found to have statistically significant differences in Shh mRNA and Smoh mRNA (P = 0.005 and P = 0.043 respectively.Conclusion: CD133+ Hepa 1–6 cells have a significantly higher colony proliferation and clonogenicity. The Shh pathway is activated in these

3He(α, γ7Be cross section in a wide energy range

Directory of Open Access Journals (Sweden)

Szücs Tamás

2017-01-01

Full Text Available The reaction rate of the 3He(α,γ7 Be reaction is important both in the Big Bang Nucleosynthesis (BBN and in the Solar hydrogen burning. There have been a lot of experimental and theoretical efforts to determine this reaction rate with high precision. Some long standing issues have been solved by the more precise investigations, like the different S(0 values predicted by the activation and in-beam measurement. However, the recent, more detailed astrophysical model predictions require the reaction rate with even higher precision to unravel new issues like the Solar composition. One way to increase the precision is to provide a comprehensive dataset in a wide energy range, extending the experimental cross section database of this reaction. This paper presents a new cross section measurement between Ecm = 2.5 − 4.4 MeV, in an energy range which extends above the 7Be proton separation threshold.

[Regional liver circulation and the scintigraphic representation of the portal circulation with 133Xe].

Science.gov (United States)

Kroiss, A

1984-01-01

Regional hepatic blood flow has been determined by 4 methods with the aid of the 133Xe washout technique: scintisplenoportography (direct application of 133Xe into the spleen by means of a thin needle); arterial method (133Xe is injected into the A. hepatica by means of a catheter); retrograde-venous method (133Xe administered by an occluding hepatic vein catheter); percutaneous intrahepatic method (133Xe administered directly into the parenchyma by means of a Chiba needle). Ad 1.: Scintisplenoportography (SSP) was executed with 97 patients: 8 patients with a healthy liver presented a hepatic blood flow of 103.37 +/- 11.5 ml/100 g/min. 4 patients with a chronic hepatitis showed a hepatic blood flow of 105.67 +/- 10.2 ml/100 g/min. In 38 patients with compensated cirrhosis, hepatic blood flow was determined with 58.15 +/- 11.5 ml/100 g/min and 19 patients with decompensated cirrhosis showed a blood flow of 34.54 +/- 7.2 ml/100 g/min. Of the 19 patients, who did not present any liver image, 2 patients suffered from a prehepatic block, 1 patient (female) from a posthepatic block, the rest were decompensated cirrhoses. In 5 patients suffering from steatosis only collateral circulation was determined and in 4 patients the spleen could not be punctured. In the patients with compensated and decompensated cirrhosis of the liver, hepatic blood flow differentiated significantly (p less than 0.001) from patients with healthy livers and chronic hepatitis. In the patients with bioptically assured steatosis only the washout constant was determined. Reproducibility of this method was tested in 4 patients and no statistical difference of hepatic blood flow values could be found and the correlation coefficient amounted to 0.9856. The advantage of SSP lies in the possibility of recording the portal vein circulation: cranial collaterals were found in 33 patients, 2 patients had caudal collaterals exclusively and 29 patients cranial and caudal collaterals. 33 cirrhosis patients

Production of pure 133mXe for CTBTO

Science.gov (United States)

Peräjärvi, K.; Eronen, T.; Gorelov, D.; Hakala, J.; Jokinen, A.; Kettunen, H.; Kolhinen, V.; Laitinen, M.; Moore, I. D.; Penttilä, H.; Rissanen, J.; Saastamoinen, A.; Toivonen, H.; Turunen, J.; Äystö, J.

2014-01-01

Underground nuclear weapon detonations release gaseous species into the atmosphere. The most interesting isotopes/isomers from the detection point of view are 131mXe, 133mXe, 133Xe and 135Xe. We have developed a method that employs high-precision Penning trap mass spectrometry at the JYFLTRAP facility, the University of Jyväskylä, to produce pure calibration samples of these isotopes/isomers. Among developments this work required a new mass resolution record of a few parts-per-million. Here the status and future plans of the project are reviewed.

Short-range second order screened exchange correction to RPA correlation energies

Science.gov (United States)

Beuerle, Matthias; Ochsenfeld, Christian

2017-11-01

Direct random phase approximation (RPA) correlation energies have become increasingly popular as a post-Kohn-Sham correction, due to significant improvements over DFT calculations for properties such as long-range dispersion effects, which are problematic in conventional density functional theory. On the other hand, RPA still has various weaknesses, such as unsatisfactory results for non-isogyric processes. This can in parts be attributed to the self-correlation present in RPA correlation energies, leading to significant self-interaction errors. Therefore a variety of schemes have been devised to include exchange in the calculation of RPA correlation energies in order to correct this shortcoming. One of the most popular RPA plus exchange schemes is the second order screened exchange (SOSEX) correction. RPA + SOSEX delivers more accurate absolute correlation energies and also improves upon RPA for non-isogyric processes. On the other hand, RPA + SOSEX barrier heights are worse than those obtained from plain RPA calculations. To combine the benefits of RPA correlation energies and the SOSEX correction, we introduce a short-range RPA + SOSEX correction. Proof of concept calculations and benchmarks showing the advantages of our method are presented.

22q13.3 Deletion Syndrome: An Underdiagnosed Cause of Mental Retardation

Directory of Open Access Journals (Sweden)

ilknur Erol

2015-03-01

Full Text Available Phelan-McDermid syndrome, also known as 22q13.3 deletion syndrome, is characterized by global developmental delay, absent or delayed speech, generalized hypotonia, and minor physical anomalies. The deletion typically involves the terminal band 22q13.3 and has been associated with both familial and de-novo translocations. We report the case of an 11-year-old Turkish girl with 22q13.3 deletion syndrome presenting with repeated seizures during the course of a rubella infection. We also review the clinical features of 22q13.3 deletion syndrome and emphasize the importance of considering a rare microdeletion syndrome for idiopathic mental retardation when results of a routine karyotype analysis are normal. To the best of our knowledge, this is the first reported case of a Turkish patient with isolated 22q13.3 deletion syndrome. [Cukurova Med J 2015; 40(1.000: 169-173

Energy-Efficient Algorithm for Sensor Networks with Non-Uniform Maximum Transmission Range

Directory of Open Access Journals (Sweden)

Yimin Yu

2011-06-01

Full Text Available In wireless sensor networks (WSNs, the energy hole problem is a key factor affecting the network lifetime. In a circular multi-hop sensor network (modeled as concentric coronas, the optimal transmission ranges of all coronas can effectively improve network lifetime. In this paper, we investigate WSNs with non-uniform maximum transmission ranges, where sensor nodes deployed in different regions may differ in their maximum transmission range. Then, we propose an Energy-efficient algorithm for Non-uniform Maximum Transmission range (ENMT, which can search approximate optimal transmission ranges of all coronas in order to prolong network lifetime. Furthermore, the simulation results indicate that ENMT performs better than other algorithms.

Cerebral distribution of 133Xe and blood flow measured with high purity germanium

International Nuclear Information System (INIS)

Reich, T.; Rusinek, H.; Youdin, M.; Clagnaz, M.

1985-01-01

Distribution of cerebral blood flow was measured with an array of 200 ultra-pure germanium radiation detectors and 133 Xe by inhalation. The array sees the head as a composite of different subvolumes and enables measurement of the concentration history of tracer every 1-10 sec in each subvolume simultaneously. Subvolume mean flows, (fm), and partition coefficients, lambda m, are derived by compartmental analysis of tissue concentration washout curves. Errors from cross talk, scalp radiation, look through, and assumed partition coefficients are eliminated. Average fm adjusted for 40 mm Hg PACO 2 in 14 cortical subvolumes (7 right, 7 left) of four normal 21-24 year old controls ranged from 50 to 60 ml/100 cc tissue/min, and lambda m ranged from 0.97 to 1.14. Average fm and lambda m in white matter was 24 ml/100 cc/min and 1.42 - 1.14 respectively. During CO 2 inhalation, right and left hemispheric fm increased 6.4% and 5.7%/mm Hg respectively, whereas white matter fm increased 2.2% and 3.4% mm Hg respectively. There was no systematic difference between front and back or dominant vs non-dominant sides. Three 73-84 year old controls had reduced fm and CO 2 reactivity in all subvolumes, lambda m was in the same range as in younger controls. Two patients with intracranial cerebrovascular disease showed excellent localization of ischemic subvolumes. One patient with asymptomatic unilateral 98% stenosis of the internal carotid artery had a similar distribution of blood flow in both hemispheres

4 CFR 28.133 - Stay proceedings.

Science.gov (United States)

2010-01-01

... GOVERNMENT ACCOUNTABILITY OFFICE GENERAL PROCEDURES GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL APPEALS BOARD; PROCEDURES APPLICABLE TO CLAIMS CONCERNING EMPLOYMENT PRACTICES AT THE GOVERNMENT ACCOUNTABILITY OFFICE Corrective Action, Disciplinary and Stay Proceedings § 28.133 Stay proceedings. (a) Prior to the effective...

Dependence of wavelength of Xe ion-induced rippled structures on the fluence in the medium ion energy range

Energy Technology Data Exchange (ETDEWEB)

Hanisch, Antje; Grenzer, Joerg [Institute of Ion Beam Physics and Materials Research, Dresden (Germany); Biermanns, Andreas; Pietsch, Ullrich [Institute of Physics, University of Siegen (Germany)

2010-07-01

Ion-beam eroded self-organized nanostructures on semiconductors offer new ways for the fabrication of high density memory and optoelectronic devices. It is known that wavelength and amplitude of noble gas ion-induced rippled structures tune with the ion energy and the fluence depending on the energy range, ion type and substrate. The linear theory by Makeev predicts a linear dependence of the ion energy on the wavelength for low temperatures. For Ar{sup +} and O{sub 2}{sup +} it was observed by different groups that the wavelength grows with increasing fluence after being constant up to an onset fluence and before saturation. In this coarsening regime power-law or exponential behavior of the wavelength with the fluence was monitored. So far, investigations for Xe ions on silicon surfaces mainly concentrated on energies below 1 keV. We found a linear dependence of both the ion energy and the fluence on the wavelength and amplitude of rippled structures over a wide range of the Xe{sup +} ion energy between 5 and 70 keV. Moreover, we estimated the ratio of wavelength to amplitude to be constant meaning a shape stability when a threshold fluence of 2.10{sup 17} cm{sup -2} was exceeded.

Measurement of home-made LaCl3 : Ce scintillation detector sensitivity with different energy points in range of fission energy

International Nuclear Information System (INIS)

Hu Mengchun; Li Rurong; Si Fenni

2010-01-01

Gamma rays of different energy were obtained in the range of fission energy by Compton scattering in intense 60 Co gamma source and the standard isotopic gamma sources which are 0.67 MeV 137 Cs and l.25 MeV 60 Co sources of point form. Sensitivity of LaCl 3 : Ce scintillator was measured in these gamma ray energy by a fast response scintillation detector with the home-made LaCl 3 : Ce scintillator. Results were normalized by the sensitivity to 0.67 MeV gamma ray. Sensitivity of LaCl 3 : Ce to 1.25 MeV gamma ray is about l.28. For ø40 mm × 2 mm LaCl 3 : Ce scintillator, the biggest sensitivity is l.18 and the smallest is 0.96 with gamma ray from 0.39 to 0.78 MeV. And for ø40 mm × 10 mm LaCl 3 : Ce scintillator, the biggest sensitivity is l.06 and the smallest is 0.98. The experimental results can provide references for theoretical study of the LaCl 3 : Ce scintillator and data to obtain the compounded sensitivity of LaCl 3 : Ce scintillator in the range of fission energy. (authors)

Mechanical valve assembly for xenon 133 gas delivery systems

Energy Technology Data Exchange (ETDEWEB)

Round, W.H. (Royal Brisbane Hospital, Herston (Australia))

Some gas delivery systems used in pulmonary ventilation scanning are unable to satisfactorily supply /sup 133/Xe gas to bed-ridden patients. A mechanical gas valve assembly to control the flow of gas in such systems was constructed. A commercially produced /sup 133/Xe gas delivery system when fitted with the new assembly was able to ventilate almost all patients whereas previously this could be achieved with approximately only 50% of patients.

19 CFR 133.46 - Demand for redelivery of released articles.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Demand for redelivery of released articles. 133.46... § 133.46 Demand for redelivery of released articles. If it is determined that articles which have been... of the port of entry shall promptly make demand for redelivery of the articles under the terms of the...

MPEG-CS/Bmi-1RNAi Nanoparticles Synthesis and Its Targeted Inhibition Effect on CD133+ Laryngeal Stem Cells.

Science.gov (United States)

Wei, Xudong; He, Jian; Wang, Jingyu; Wang, Wei

2018-03-01

Previous studies have confirmed that CD133+ cells in laryngeal tumor tissue have the characteristics of cancer stem cells. Bmi-1 gene expression is central to the tumorigenicity of CD133+ cells. In this study, we tried to develop a new siRNA carrier system using chitosan-methoxypolyethylene nanoparticles (CS-mPEG-NPs) that exhibit higher tumor-targeting ability and enhanced gene silencing efficacy in CD133+ tumor stem cells. It is hoped to block the self-renewal and kill the stem cells of laryngeal carcinoma. The mPEG-CS-Bmi-1RNAi-NPs were synthesized and their characters were checked. The changes in invasion ability and sensitivity to radiotherapy and chemotherapy of CD133+Hep-2 tumor cells were observed after Bmi-1 gene silencing. The mPEG-CS-Bmi-1RNAi-NPs synthesized in this experiment have a regular spherical form, a mean size of 139.70 ±6.40 nm, an encapsulation efficiency of 85.21 ± 1.94%, with drug loading capacity of 18.47 ± 1.83%, as well as low cytotoxicity, providing good protection to the loaded gene, strong resistance to nuclease degradation and high gene transfection efficiency. After Bmi-1 gene silencing, the invasion ability of CD133+ cells was weakened. Co-cultured with paclitaxel, the survival rates of CD133+Bmi-1RNAi cells were lower. After radiotherapy, the mean growth inhibition rate of CD133+/Bmi-1RNAi cells was significantly lower than CD133+ cells. In conclusion, the mPEG-CS nano-carrier is an ideal vector in gene therapy, while silencing the Bmi-1 gene can enhance the sensitivity of CD133+ tumor stem cells to chemoradiotherapy and abate their invasion ability.

CD133+ cells contribute to radioresistance via altered regulation of DNA repair genes in human lung cancer cells

International Nuclear Information System (INIS)

Desai, Amar; Webb, Bryan; Gerson, Stanton L.

2014-01-01

Background: Radioresistance in human tumors has been linked in part to a subset of cells termed cancer stem cells (CSCs). The prominin 1 (CD133) cell surface protein is proposed to be a marker enriching for CSCs. We explore the importance of DNA repair in contributing to radioresistance in CD133+ lung cancer cells. Materials and methods: A549 and H1299 lung cancer cell lines were used. Sorted CD133+ cells were exposed to either single 4 Gy or 8 Gy doses and clonogenic survival measured. ϒ-H2AX immunofluorescence and quantitative real time PCR was performed on sorted CD133+ cells both in the absence of IR and after two single 4 Gy doses. Lentiviral shRNA was used to silence repair genes. Results: A549 but not H1299 cells expand their CD133+ population after single 4 Gy exposure, and isolated A549 CD133+ cells demonstrate IR resistance. This resistance corresponded with enhanced repair of DNA double strand breaks (DSBs) and upregulated expression of DSB repair genes in A549 cells. Prior IR exposure of two single 4 Gy doses resulted in acquired DNA repair upregulation and improved repair proficiency in both A549 and H1299. Finally Exo1 and Rad51 silencing in A549 cells abrogated the CD133+ IR expansion phenotype and induced IR sensitivity in sorted CD133+ cells. Conclusions: CD133 identifies a population of cells within specific tumor types containing altered expression of DNA repair genes that are inducible upon exposure to chemotherapy. This altered gene expression contributes to enhanced DSB resolution and the radioresistance phenotype of these cells. We also identify DNA repair genes which may serve as promising therapeutic targets to confer radiosensitivity to CSCs

19p13.3 aberrations are associated with dysmorphic features and deviant psychomotor development.

Science.gov (United States)

Siggberg, L; Olsén, P; Näntö-Salonen, K; Knuutila, S

2011-01-01

Here, we describe 2 patients with de novo genomic imbalances of 19p13.3. Using high-resolution microarray analysis, we detected a 1.25-Mb deletion in one patient and a 0.81- Mb duplication in another. The resulting phenotypes are quite different; one is a 2-year-old boy with macrocephaly and normal growth, while the other is a 9-year-old boy with microcephaly and growth retardation since birth. Both have dysmorphic features and psychomotor developmental delay. This report gives evidence of the effect of small aberrations of chromosome 19 and describes the phenotypes arising from a duplication and deletion of the same location at 19p13.3. Copyright © 2010 S. Karger AG, Basel.

Application of long range energy alternative planning (LEAP) model for Thailand energy outlook 2030 : reference case

International Nuclear Information System (INIS)

Charusiri, W.; Eua-arporn, B.; Ubonwat, J.

2008-01-01

In 2004, the total energy consumption in Thailand increased 8.8 per cent, from 47,806 to 60,260 ktoe. Long-range Energy Alternatives Planning (LEAP) is an accounting tool that simulates future energy scenarios. According to a Business As Usual (BAU) case, the overall energy demand in Thailand is estimated to increase from 61,262 to 254,200 ktoe between 2004 and 2030. Commercial energy consumption, which comprises petroleum products, natural gas, coal and its products, and electricity, increased by 9.0 per cent in Thailand in 2004, and new and renewable energy increased by 7.8 per cent. Nearly 60 per cent of the total commercial energy supply in Thailand was imported and increased for a fifth year in a row. The changes in energy consumption can be attributed to population growth and increase in economic activity and development. 10 refs., 5 tabs., 14 figs

Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a

Science.gov (United States)

Singh, Jagmohan; Boopathi, Ettickan; Addya, Sankar; Phillips, Benjamin; Rigoutsos, Isidore; Penn, Raymond B.

2016-01-01

A comprehensive genomic and proteomic, computational, and physiological approach was employed to examine the (previously unexplored) role of microRNAs (miRNAs) as regulators of internal anal sphincter (IAS) smooth muscle contractile phenotype and basal tone. miRNA profiling, genome-wide expression, validation, and network analyses were employed to assess changes in mRNA and miRNA expression in IAS smooth muscles from young vs. aging rats. Multiple miRNAs, including rno-miR-1, rno-miR-340-5p, rno-miR-185, rno-miR-199a-3p, rno-miR-200c, rno-miR-200b, rno-miR-31, rno-miR-133a, and rno-miR-206, were found to be upregulated in aging IAS. qPCR confirmed the upregulated expression of these miRNAs and downregulation of multiple, predicted targets (Eln, Col3a1, Col1a1, Zeb2, Myocd, Srf, Smad1, Smad2, Rhoa/Rock2, Fn1, Tagln v2, Klf4, and Acta2) involved in regulation of smooth muscle contractility. Subsequent studies demonstrated an aging-associated increase in the expression of miR-133a, corresponding decreases in RhoA, ROCK2, MYOCD, SRF, and SM22α protein expression, RhoA-signaling, and a decrease in basal and agonist [U-46619 (thromboxane A2 analog)]-induced increase in the IAS tone. Moreover, in vitro transfection of miR-133a caused a dose-dependent increase of IAS tone in strips, which was reversed by anti-miR-133a. Last, in vivo perianal injection of anti-miR-133a reversed the loss of IAS tone associated with age. This work establishes the important regulatory effect of miRNA-133a on basal and agonist-stimulated IAS tone. Moreover, reversal of age-associated loss of tone via anti-miR delivery strongly implicates miR dysregulation as a causal factor in the aging-associated decrease in IAS tone and suggests that miR-133a is a feasible therapeutic target in aging-associated rectoanal incontinence. PMID:27634012

Online Energy Management of Plug-In Hybrid Electric Vehicles for Prolongation of All-Electric Range Based on Dynamic Programming

Directory of Open Access Journals (Sweden)

Zeyu Chen

2015-01-01

Full Text Available The employed energy management strategy plays an important role in energy saving performance and exhausted emission reduction of plug-in hybrid electric vehicles (HEVs. An application of dynamic programming for optimization of power allocation is implemented in this paper with certain driving cycle and a limited driving range. Considering the DP algorithm can barely be used in real-time control because of its huge computational task and the dependence on a priori driving cycle, several online useful control rules are established based on the offline optimization results of DP. With the above efforts, an online energy management strategy is proposed finally. The presented energy management strategy concerns the prolongation of all-electric driving range as well as the energy saving performance. A simulation study is deployed to evaluate the control performance of the proposed energy management approach. All-electric range of the plug-in HEV can be prolonged by up to 2.86% for a certain driving condition. The energy saving performance is relative to the driving distance. The presented energy management strategy brings a little higher energy cost when driving distance is short, but for a long driving distance, it can reduce the energy consumption by up to 5.77% compared to the traditional CD-CS strategy.

Determination of skin blood flow by 133Xe washout and by heat flux from a heated tc-Po2 electrode

International Nuclear Information System (INIS)

Jaszczak, P.; Sejrsen, P.

1984-01-01

133 Xe washout measurements were used to determine cutaneous and subcutaneous blood flow beneath a specially designed double-thermostated tc-Po 2 electrode. The skin blood flow was determined using thermal methods based on reduced heat dissipation during blood flow cessation. A total of 20 measurements were performed on two healthy volunteers, using the volar side of the right forearm as the experimental area. Cutaneous as well as subcutaneous blood flow increased with increasing electrode temperature. The cutaneous blood flow increased from 12.3 +- 1.3 ml (100 g) -1 . min -1 (37degC) to 49.1 +- 5.4 ml (100g) -1 . min -1 (45degC) and the subcutaneous values from 20.9 +- 0.2 ml (100 g) -1 . min -1 to 57.3 +- 0.5 ml(100 g) -1 . min -1 . Preheating of the measuring area or injection of papaverine as blood flow accelerator did not increase the maximum blood flow values. A considerable inter-individual difference between cutaneous and subcutaneous blood flow was observed, but in spite of that a good overall correlation between the 133 Xe washout measurements and the two thermal flow measurements was found (r = 0.932 and 0.945, respectively). It is concluded that in some cases, but not always, measurements of tc-Po 2 at electrode temperatures of 45degC take place on a maximally perfused skin and that it is possible to determine skin blood flow by means of determinations of the heat dissipated from the tc-Po 2 electrode to the underlying skin. (author)

Development of dose monitoring system applicable to various radiations with wide energy ranges

International Nuclear Information System (INIS)

Sato, Tatsuhiko; Satoh, Daiki; Endo, Akira

2006-01-01

A new radiation dose monitor, designated as DARWIN (Dose monitoring system Applicable to various Radiations with WIde energy raNges), has been developed for real-time monitoring of doses in workspaces and surrounding environments of high energy accelerator facilities. DARWIN is composed of a phoswitch-type scintillation detector, which consists of liquid organic scintillator BC501A coupled with ZnS(Ag) scintillation sheets doped with 6 Li, and a data acquisition system based on a Digital-Storage-Oscilloscope. DARWIN has the following features: (1) capable of monitoring doses from neutrons, photons and muons with energies from thermal energy to 1 GeV, 150 keV to 100 MeV, and 1 MeV to 100 GeV, respectively, (2) highly sensitive with precision, and (3) easy to operate with a simple graphical user-interface. The performance of DARWIN was examined experimentally in several radiation fields. The results of the experiments indicated the accuracy and rapid response of DARWIN for measuring dose rates from neutrons, photons and muons with wide energies. With these properties, we conclude that DARWIN will be able to play a very important role for improving radiation safety in high energy accelerator facilities. (author)

The optimization of 18F-nucleophilic fluorination reaction and its application in synthesis of VMAT2 imaging tracer: [18F]AV-133

International Nuclear Information System (INIS)

Liu Yajing; Zhu Lin; Karl, P.; Qu Wenchao

2010-01-01

Objective: The nucleophilic introduction of n.c.a. [ 18 F]F- into alkanes by nucleophilic reaction is the main method of preparing 18 F-labelled radiopharmaceuticals, and the efficient and rapid reaction is important in 18 F-labelled radiopharmaceuticals. Method: Using 2-(3-substitute propoxy)naphthalene as model compound, the optimal reaction condition was achieved by comparing the different [ 18 F]fluorination condition: 1)different leaving groups (-OTs, -I, -Br and -Cl), 2) different [ 18 F]fluorination catalysts (Kryptofix222/K 2 CO 3 and TBAHCO 3 ), 3) different reaction solvent (ACN, DMSO and DMF), 4) [ 18 F]fluorination temperature (40, 50 and 60 degree C) and 5) reaction time. The radiochemical yields were analyzed by TLC and HPLC. VMAT2 imaging tracer [ 18 F]AV-133 was synthesized under the optimal conditions. Results: From the experiment results, the reation activity was the highest when using -OTs as the leaving group, followed by -I and -Br, -Clunder the [ 18 F]fluorination condition of using K222/K 2 CO 3 as catalyst and ACN as solvent. And also, the radiochemical yield raised as the reaction time and temperature increased. The higher temperature, the shorter time to reach the equilibrium. When changing the solvent from ACN to DMSO, the radiochemical yields were increased. On the contrary, the radiochemical yields were decreasing by using DMF. Comparing the catalyst K222/K 2 CO 3 with TBAHCO 3 , the [ 18 F] fluorination of -OTs gave a higher radiochemical yield in the presence of K222/K 2 CO 3 . So the optimized [ 18 F]fluorination reaction condition was that choosing -OTs as the leaving group, the [ 18 F]fluorination reaction was efficient and gave higher radiochemical yield catalyzed by K222/K 2 CO 3 in DMSO at high temperature. [ 18 F]fluorination of AV-244 was found to provide the VMAT2 imaging tracer [ 18 F]AV-133 in 80 ± 2% radiochemical yield after reaction at 120 degree C for 3 min under optimized conditions. Conclusion: We have described an

Renewable Energy Opportunities at White Sands Missile Range, New Mexico

Energy Technology Data Exchange (ETDEWEB)

Chvala, William D.; Solana, Amy E.; States, Jennifer C.; Warwick, William M.; Weimar, Mark R.; Dixon, Douglas R.

2008-09-01

The document provides an overview of renewable resource potential at White Sands Missile Range (WSMR) based primarily upon analysis of secondary data sources supplemented with limited on-site evaluations. The effort was funded by the U.S. Army Installation Management Command (IMCOM) as follow-on to the 2005 DoD Renewable Energy Assessment. This effort focuses on grid-connected generation of electricity from renewable energy sources and also ground source heat pumps (GSHPs) for heating and cooling buildings, as directed by IMCOM.

CO2 reduction through energy conservation

International Nuclear Information System (INIS)

1991-05-01

A study was carried out of the potential to economically reduce carbon dioxide emissions through energy conservation in the petroleum and natural gas industry. The study examined current and projected emissions levels, cogeneration at gas plants, flaring, economics, regulation, reporting requirements, implementation, and research and development. Economically attractive energy conservation measures can reduce oil and gas industry, exclusive of Athabasca oil sands operations, CO 2 emissions by 6-7%. The energy conservation options identified range from field energy awareness committees through to equipment retrofits and replacement. At ca 3 million tonnes/y, these reductions will not offset the increases in oil and gas related CO 2 emissions anticipated by producers and Alberta government agencies. There will be increasing emphasis on in-situ bitumen production, more energy intensive light crude oil production and increasing natural gas sales, increasing energy inputs in excess of reductions. Cogeneration of electricity for utility company distribution and for internally required steam at gas plants and in-situ production sites is not economic due to low electricity prices. 8 tabs

Partial wave analysis of DM2 data in the η(1430) energy range

International Nuclear Information System (INIS)

Augustin, J.E.; Cosme, G.; Couchot, F.; Fulda, F.; Grosdidier, G.; Jean-Marie, B.; Lepeltier, V.; Szklarz, G.; Bisello, D.; Busetto, G.; Castro, A.; Pescara, L.; Sartori, P.; Stanco, L.; Ajaltouni, Z.; Falvard, A.; Jousset, J.; Michel, B.; Montret, J.C.

1990-10-01

Partial Wave Analysis of the J/ψ → γK S 0 K ± π -+ , γK ± K -+ π 0 decays in the ι/η(1430) mass range shows a clear pseudoscalar dominance, with two dynamical components. The main one, centered at ∼ 1460 MeV/c 2 , proceeds via a 0 (980)π dynamics, while the second one with K*(892)K dynamics is peaked at ∼ 1420 MeV/c 2 , close to its threshold. In addition, the higher part of the mass spectrum contains a significant contribution from the 1 ++ K*(892)K wave. In the PWA of the J/ψ → γηπ + π - channel a resonant a 0 π production is observed slightly below 1400 MeV/c 2

Xenon-133 determination of muscle blood flow: Use in evaluating cardioactive drugs

International Nuclear Information System (INIS)

Wexler, J.P.; Davis, L.; Mancini, D.; Chadwick, B.; Le Jemtel, T.

1985-01-01

Cardioactive drugs may effect both the central and peripheral circulatory systems. The effects on the central and peripheral circulatory systems of chronic Captorpril therapy in 7 pts with severe congestive heart failure (CHF) were evaluated simultaneously. Skeletal muscle blood flow (SMBF) determined using 133-Xe washout and a Cd/Te detector, oxygen consumption (VO/sub 2/), and radial artery and femoral vein O/sub 2/ concentration difference (A-V) were determined at rest and peak upright bicycle exercise before (BT) and after (AT) 6-12 weeks of Captopril therapy. In CI pts there was a significant increase in VO/sub 2/ and SMBF AT vs BT. In contrast, in CNC pts there was no change in VO/sub 2/ and a significant decrease in SMBF AT vs BT. In pts with severe CHF who are CI, there is an apparent fall in peripheral vascular resistance (PVR). In contrast, in CNC pts there is an increase in PVR. This study demonstrates that SMBF determines using 133-Xe is an important method for determining the effects of cardioactive drugs

miR-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction

Directory of Open Access Journals (Sweden)

Alberto Izarra

2014-12-01

Full Text Available miR-133a and miR-1 are known as muscle-specific microRNAs that are involved in cardiac development and pathophysiology. We have shown that both miR-1 and miR-133a are early and progressively upregulated during in vitro cardiac differentiation of adult cardiac progenitor cells (CPCs, but only miR-133a expression was enhanced under in vitro oxidative stress. miR-1 was demonstrated to favor differentiation of CPCs, whereas miR-133a overexpression protected CPCs against cell death, targeting, among others, the proapoptotic genes Bim and Bmf. miR-133a-CPCs clearly improved cardiac function in a rat myocardial infarction model by reducing fibrosis and hypertrophy and increasing vascularization and cardiomyocyte proliferation. The beneficial effects of miR-133a-CPCs seem to correlate with the upregulated expression of several relevant paracrine factors and the plausible cooperative secretion of miR-133a via exosomal transport. Finally, an in vitro heart muscle model confirmed the antiapoptotic effects of miR-133a-CPCs, favoring the structuration and contractile functionality of the artificial tissue.

Autonomous Vehicles Have a Wide Range of Possible Energy Impacts (Poster)

Energy Technology Data Exchange (ETDEWEB)

Brown, A.; Repac, B.; Gonder, J.

2013-07-01

This poster presents initial estimates of the net energy impacts of automated vehicles (AVs). Automated vehicle technologies are increasingly recognized as having potential to decrease carbon dioxide emissions and petroleum consumption through mechanisms such as improved efficiency, better routing, lower traffic congestion, and by enabling advanced technologies. However, some effects of AVs could conceivably increase fuel consumption through possible effects such as longer distances traveled, increased use of transportation by underserved groups, and increased travel speeds. The net effect on petroleum use and climate change is still uncertain. To make an aggregate system estimate, we first collect best estimates for the energy impacts of approximately ten effects of AVs. We then use a modified Kaya Identity approach to estimate the range of aggregate effects and avoid double counting. We find that depending on numerous factors, there is a wide range of potential energy impacts. Adoption of automated personal or shared vehicles can lead to significant fuel savings but has potential for backfire.

Photon stimulated desorption investigations of positive ions of MgO, TiO2, Yb2O3, Nd2O3, H2O/Si(100), CaF2/Si and of H2O, CO and NO on Yb and Nd in the energy range 14 eV up to 800 eV

International Nuclear Information System (INIS)

Senf, F.

1987-01-01

Photon-stimulated desorption of positive ions from surfaces has been studied with synchrotron radiation in the photon energy range 14 -800 eV of the 'FLIPPER'-monochromator using a time-of-flight mass spectrometer. TiO 2 , as a prototype of a maximal valency ionic compound, shows a strong desorption of O +- in the photon energy range of the Ti 3 p → 3d- and Ti 2p → 3d-resonance as well as at the 0 1s-excitation due to intraatomic respectively intraatomic Auger decays, which is in agreement with the Knotek-Feibelman model. The desorption of F + from CaF 2 -covered silicon is found to follow the respective excitation and decay processes in Ca and F. In addition, the very large cross section for the F + desorption causes a radiation damage by photons of more than about 30 eV. The adsorbate system H 2 O/Si (100) needs a multiple electron excitation to show a significant desorption setting in only 30 eV above the 0 1s threshold. The rare earth metals Yb and Nd covered with O 2 , H 2 O, CO or NO exhibit a competitive desorption of O + partly due to intraatomic Auger decays caused by single electron excitations and partly due to multiple electron excitations. The variation of the 0 + yield with regard to the different adsorbates on Yb and Nd is unexpectedly low. A detailed investigation was concerned with thin oxidized Mg-films and differently prepared MgO-single-crystals. Here we found a very efficient desorption of O + and H + resulting from the excitation of O 1s-surface-excitons. In addition, the strong hole-hole-interaction energy of crystalline MgO appears to be responsible for a suppressed O + -signal in the energy range of the Mg 2p-excitation. (orig./BHO)

Polaron variable range hopping in TiO2-δ(-0.04=<δ=<0.2) thin films

International Nuclear Information System (INIS)

Heluani, S.P.; Comedi, D.; Villafuerte, M.; Juarez, G.

2007-01-01

The mechanisms of electrical conduction in TiO 2-δ (-0.04= 2 +Ar gas atmospheres where changes in δ and film structure had been achieved by varying the O 2 flow rate and the substrate temperature. The electrical transport properties of these samples were investigated by measuring the conductivity as a function of temperature between 17K and room temperature. At the temperature range between 200 and 290K the best fit to the experimental data was obtained assuming a dependence characteristic of adiabatic variable range hopping. At lower temperature the activation energy for the conductivity tends to zero. The results suggest that the conduction mechanism is adiabatic small polaron hopping, which switches to conduction in a polaron band at low temperatures

Tables of range and rate of energy loss of charged particles of energy 0,5 to 150 MeV

Energy Technology Data Exchange (ETDEWEB)

Williamson, C; Boujot, J P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1962-07-01

The accurate knowledge of ranges and rates of energy loss of charged particles is very important for physicists working with nuclear accelerators. The tabulations of Aron, Hoffmann, and Williams and later of Madey and Rich have proved extremely useful. However, recent experimental range measurements have indicated the need for a new tabulation of the range-energy relation. It was felt that a useful purpose would be served by performing the calculations for a large number of stopping materials distributed throughout the periodic table, including the materials most commonly used as targets, detectors, and entrance foils. (authors)

Defect formation energies and homogeneity ranges of rock salt-, pyrite-, chalcopyrite- and molybdenite-type compound semiconductors

Energy Technology Data Exchange (ETDEWEB)

Fiechter, S. [Hahn-Meitner-Institut, Glienicker Strasse 100, Berlin D-14109 (Germany)

2004-07-01

Employing the generalisation of Van Vechten's cavity model, formation energies of neutral point defects in pyrites (FeS{sub 2}, RuS{sub 2}), chalcopyrites (II-IV-V{sub 2} and I-III-VI{sub 2}) as well as molybdenites (MoS{sub 2}, WS{sub 2}) have been estimated. As input parameters the fundamental band gaps, work functions, electron affinities, surface energies, coordination numbers, covalent or ionic radii and unit cell parameters were used. The values calculated for tetrahedrally and octahedrally coordinated compounds agreed well with measured values. The data obtained can be used to calculate point defect concentrations and homogeneity ranges as a function of partial pressure and temperature. Introducing charged vacancies, the conductivity type can be predicted.

Water Ice Radiolytic O2, H2, and H2O2 Yields for Any Projectile Species, Energy, or Temperature: A Model for Icy Astrophysical Bodies

Science.gov (United States)

Teolis, B. D.; Plainaki, C.; Cassidy, T. A.; Raut, U.

2017-10-01

O2, H2, and H2O2 radiolysis from water ice is pervasive on icy astrophysical bodies, but the lack of a self-consistent, quantitative model of the yields of these water products versus irradiation projectile species and energy has been an obstacle to estimating the radiolytic oxidant sources to the surfaces and exospheres of these objects. A major challenge is the wide variation of O2 radiolysis yields between laboratory experiments, ranging over 4 orders of magnitude from 5 × 10-7 to 5 × 10-3 molecules/eV for different particles and energies. We revisit decades of laboratory data to solve this long-standing puzzle, finding an inverse projectile range dependence in the O2 yields, due to preferential O2 formation from an 30 Å thick oxygenated surface layer. Highly penetrating projectile ions and electrons with ranges ≳30 Å are therefore less efficient at producing O2 than slow/heavy ions and low-energy electrons (≲ 400 eV) which deposit most energy near the surface. Unlike O2, the H2O2 yields from penetrating projectiles fall within a comparatively narrow range of (0.1-6) × 10-3 molecules/eV and do not depend on range, suggesting that H2O2 forms deep in the ice uniformly along the projectile track, e.g., by reactions of OH radicals. We develop an analytical model for O2, H2, and H2O2 yields from pure water ice for electrons and singly charged ions of any mass and energy and apply the model to estimate possible O2 source rates on several icy satellites. The yields are upper limits for icy bodies on which surface impurities may be present.

MicroRNA-133 mediates cardiac diseases: Mechanisms and clinical implications

Energy Technology Data Exchange (ETDEWEB)

Liu, Yi; Liang, Yan [Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang 524023, Guangdong (China); Zhang, Jin-fang [Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong (China); Fu, Wei-ming, E-mail: fuweiming76@smu.edu.cn [School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515 (China)

2017-05-15

MicroRNAs (miRNAs) belong to the family of small non-coding RNAs that mediate gene expression by post-transcriptional regulation. Increasing evidence have demonstrated that miR-133 is enriched in muscle tissues and myogenic cells, and its aberrant expression could induce the occurrence and development of cardiac disorders, such as cardiac hypertrophy, heart failure, etc. In this review, we summarized the regulatory roles of miR-133 in cardiac disorders and the underlying mechanisms, which suggest that miR-133 may be a potential diagnostic and therapeutic tool for cardiac disorders. - Highlights: • miR-218 is frequently downregulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

MicroRNA-133 mediates cardiac diseases: Mechanisms and clinical implications

International Nuclear Information System (INIS)

Liu, Yi; Liang, Yan; Zhang, Jin-fang; Fu, Wei-ming

2017-01-01

MicroRNAs (miRNAs) belong to the family of small non-coding RNAs that mediate gene expression by post-transcriptional regulation. Increasing evidence have demonstrated that miR-133 is enriched in muscle tissues and myogenic cells, and its aberrant expression could induce the occurrence and development of cardiac disorders, such as cardiac hypertrophy, heart failure, etc. In this review, we summarized the regulatory roles of miR-133 in cardiac disorders and the underlying mechanisms, which suggest that miR-133 may be a potential diagnostic and therapeutic tool for cardiac disorders. - Highlights: • miR-218 is frequently downregulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

24 CFR 17.133 - Written agreement to repay debt as alternative to salary offset.

Science.gov (United States)

2010-04-01

... alternative to salary offset. 17.133 Section 17.133 Housing and Urban Development Office of the Secretary... the Government Salary Offset Provisions § 17.133 Written agreement to repay debt as alternative to salary offset. (a) Notification by employee. The employee may propose, in response to a Notice of Intent...

Pulse height defect in ion implanted silicon detector for heavy ions with Z=6-28 in the energy range ∼ 0.25-2.5 MeV/u

International Nuclear Information System (INIS)

Diwan, P.K.; Sharma, V.; Shyam Kumar; Avasthi, D.K.

2005-01-01

The response of ion implanted silicon detector has been studied for heavy ions with Z= 6-28 in the energy range ∼ 0.25-2.5 MeV/u utilizing the 15UD Pelletron Accelerator facility at Nuclear Science Centre, New Delhi, India. The variation of pulse height in ion implanted silicon detector with projectile's atomic number and its energy have been investigated. It has been observed that pulse height-energy calibration for a given projectile is described well by a linear relationship indicating no pulse height defect with the variation in energy for specific Z projectile. Pulse height defect has been found to increase with increasing projectile atomic number. The mean slope of the collected charge signal versus projectile energy depends significantly on the atomic number of the projectile. (author)

Electronic energy distribution function at high electron swarm energies in neon

International Nuclear Information System (INIS)

Brown, K.L.; Fletcher, J.

1995-01-01

Electron swarms moving through a gas under the influence of an applied electric field have been extensively investigated. Swarms at high energies, as measured by the ratio of the applied field to the gas number density, E/N, which are predominant in many applications have, in general, been neglected. Discharges at E/N in the range 300 0 < 133 Pa using a differentially pumped vacuum system in which the swarm electrons are extracted from the discharge and energy analysed in both a parallel plate retarded potential analyser and a cylindrical electrostatic analyser. Both pre-breakdown and post-breakdown discharges have been studied. Initial results indicate that as the discharge traverses breakdown no sudden change in the nature of the discharge occurs and that the discharge can be described by both a Monte Carlo simulation and by a Boltzmann treatment given by Phelps et al. (1987). 18 refs., 8 figs

Regional cerebral blood flow (RCBF) measurements by SPECT analysis of Xenon-133 transit: Validation of technique and clinical correlation

International Nuclear Information System (INIS)

Rezai, K.; Kirchner, P.; Armstrong, C.; Ehrhardt, J.; Damasio, H.; Adams, H.; Damasio, A.

1984-01-01

The SPECT system (Tomomatic-64) developed by a previous study for rCBF measurements with Xe-133 was validated with phantom simulations and clinical studies. A bi-compartmental flow phantom was developed consisting of a Xenon-133 pump connected in series to head and lung compartments. Flow rates between 0.2 and 1.4 brain volumes/min (20-140 cc/100ml/min) were tested against Tomomatic measurements by linear regression. Correlation was excellent (r=1.0) in the range of 0.2-1.2 (20-120 cc/100ml/min), representing flow rates which are most likely to be encountered in clinical studies. Flow rates above 1.2 (120 cc/100 ml/min) were significantly underestimated. 32 studies on 20 volunteers gave a mean normal flow of 72 (SD=12) cc/ 100g/min. Mean regional flow ranged from 62 in frontal lobes to 75 in central gray matter. Right-to-left variation was less than 5%. The lowest regional flow in a normal subject was 45 cc/100g/min. 68 studies were performed on 30 stroke patients. In 27 rCBF was less than 45 in affected brain areas for a sensitivity of 90% which improved to 97% when comparisons with contralateral brain were included. Initial CT scans were normal or non-diagnostic in 10, but showed CVA's in regions of reduced rCBF in 17 patients. rCBF abnormalities involved greater portions of brain than CT changes, often (8/17) including distant regions, unpredicted by CT or clinical studies but known to be strongly interconnected to the area of structural damage. SPECT estimates of rCBF appear to be a sensitive research and diagnostic tool and complement the structural information provided by CT

Calibration of high-dynamic-range, finite-resolution x-ray pulse-height spectrometers for extracting electron energy distribution data from the PFRC-2 device

Science.gov (United States)

Swanson, C.; Jandovitz, P.; Cohen, S. A.

2017-10-01

Knowledge of the full x-ray energy distribution function (XEDF) emitted from a plasma over a large dynamic range of energies can yield valuable insights about the electron energy distribution function (EEDF) of that plasma and the dynamic processes that create them. X-ray pulse height detectors such as Amptek's X-123 Fast SDD with Silicon Nitride window can detect x-rays in the range of 200eV to 100s of keV. However, extracting EEDF from this measurement requires precise knowledge of the detector's response function. This response function, including the energy scale calibration, the window transmission function, and the resolution function, can be measured directly. We describe measurements of this function from x-rays from a mono-energetic electron beam in a purpose-built gas-target x-ray tube. Large-Z effects such as line radiation, nuclear charge screening, and polarizational Bremsstrahlung are discussed.

Energy System Expectations for Nuclear in the 21. Century: A Plausible Range

International Nuclear Information System (INIS)

Langlois, Lucille M.; McDonald, Alan; Rogner, Hans-Holger; Vera, Ivan

2002-01-01

This paper outlines a range of scenarios describing what the world's energy system might look like in the middle of the century, and what nuclear energy's most profitable role might be. The starting point is the 40 non-greenhouse-gas-mitigation scenarios in the Special Report on Emissions Scenarios (SRES) of the Intergovernmental Panel on Climate Change (IPCC, 2000). Given their international authorship and comprehensive review by governments and scientific experts, the SRES scenarios are the state of the art in long-term energy scenarios. However, they do not present the underlying energy system structures in enough detail for specific energy technology and infrastructure analyses. This paper therefore describes initial steps within INPRO (The International Project on Innovative Nuclear Reactors and Fuel Cycles of the International Atomic Energy Agency) to translate the SRES results into a range of possible nuclear energy technology requirements for mid-century. The paper summarizes the four SRES scenarios that will be used in INPRO and the reasons for their selection. It provides illustrative examples of the sort of additional detail that is being developed about the overall energy system implied by each scenario, and about specific scenario features particularly relevant to nuclear energy. As recommended in SRES, the selected scenarios cover all four SRES 'story-line families'. The energy system translations being developed in INPRO are intended to indicate how energy services may be provided in mid-century and to delineate likely technology and infrastructure implications. They will indicate answers to questions like the following. The list is illustrative, not comprehensive. - What kind of nuclear power plants will best fit the mid-century energy system? - What energy forms and other products and services provided by nuclear reactors will best fit the mid-century energy system? - What would be their market shares? - How difficult will it be to site new nuclear

Effects of cytokine combinations on the cell cycle and early apoptosis of irradiated umbilical cord blood AC133+ cells

International Nuclear Information System (INIS)

Liu Yulong; Dai Hong; Jiang Zhong; Zhou Liying; Guo Xiaokui; Zhou Jianying

2005-01-01

The cell cycle and early apoptosis of 2.5 Gy 6 MV-X ray irradiated umbilical cord blood AC133 + cells cultured with cytokine combinations (IL-3 + FL + SCF) were immunolabelled and analyzed by flow cytometry at d 0, 1, 2, 3 and 7. The result of flow cytometry analysis showed that majority of irradiated umbilical cord blood AC133 + cells were in G 0 /G 1 phase of the cell cycle at d 0. Under the influence of cytokine combinations (IL-3 + FL + SCF), nearly 50% of cells were in S phase on 3rd day. AC133 + cells irradiated were in vitro incubated in the medium without cytokines, nearly all cells died by apoptosis. However, when we incubated cells with cytokine combinations (IL-3 + FL + SCF), (38.0 ± 6.8)% of cells were saved from apoptosis at d 2. The more percent of saved AC133 + cells became to proliferate with the extension of culture. In short, cytokine combinations (IL-3 + FL + SCF) could have a key role to protect irradiated cells and partially avoid induction of apoptosis by ionizing radiation in hematopoietics stem/progenitor cells. (authors)

Advanced Range Safety System for High Energy Vehicles

Science.gov (United States)

Claxton, Jeffrey S.; Linton, Donald F.

2002-01-01

The advanced range safety system project is a collaboration between the National Aeronautics and Space Administration and the United States Air Force to develop systems that would reduce costs and schedule for safety approval for new classes of unmanned high-energy vehicles. The mission-planning feature for this system would yield flight profiles that satisfy the mission requirements for the user while providing an increased quality of risk assessment, enhancing public safety. By improving the speed and accuracy of predicting risks to the public, mission planners would be able to expand flight envelopes significantly. Once in place, this system is expected to offer the flexibility of handling real-time risk management for the high-energy capabilities of hypersonic vehicles including autonomous return-from-orbit vehicles and extended flight profiles over land. Users of this system would include mission planners of Space Launch Initiative vehicles, space planes, and other high-energy vehicles. The real-time features of the system could make extended flight of a malfunctioning vehicle possible, in lieu of an immediate terminate decision. With this improved capability, the user would have more time for anomaly resolution and potential recovery of a malfunctioning vehicle.

3-Bromopyruvate inhibits cell proliferation and induces apoptosis in CD133+ population in human glioma.

Science.gov (United States)

Xu, Dong-Qiang; Tan, Xiao-Yu; Zhang, Bao-Wei; Wu, Tao; Liu, Ping; Sun, Shao-Jun; Cao, Yin-Guang

2016-03-01

The study was aimed to investigate the role of 3-bromopyruvate in inhibition of CD133+ U87 human glioma cell population growth. The results demonstrated that 3-bromopyruvate inhibited the viability of both CD133+ and parental cells derived from U87 human glioma cell line. However, the 3-bromopyruvate-induced inhibition in viability was more prominent in CD133+ cells at 10 μM concentration after 48 h. Treatment of CD133+ cells with 3-bromopyruvate caused reduction in cell population and cell size, membrane bubbling, and degradation of cell membranes. Hoechst 33258 staining showed condensation of chromatin material and fragmentation of DNA in treated CD133+ cells after 48 h. 3-Bromopyruvate inhibited the migration rate of CD133+ cells significantly compared to the parental cells. Flow cytometry revealed that exposure of CD133+ cells to 3-bromopyruvate increased the cell population in S phase from 24.5 to 37.9 % with increase in time from 12 to 48 h. In addition, 3-bromopyruvate significantly enhanced the expression of Bax and cleaved caspase 3 in CD133+ cells compared to the parental cells. Therefore, 3-bromopyruvate is a potent chemotherapeutic agent for the treatment of glioma by targeting stem cells selectively.

Measurement and analysis of excitation functions in 16O + 103Rh system in the excitation energy range ≅ 2-4 MeV/A

International Nuclear Information System (INIS)

Singh, Devendra P.; Unnati; Sharma, Manoj Kumar; Singh, Pushpendra P.; Singh, B.P.; Prasad, R.; Gupta, Sunita; Rakesh Kumar; Bhardwaj, H.D.

2006-01-01

In the present work, excitation functions for seven evaporation residues (ERs) produced via complete fusion and incomplete fusion processes in 16 O + 103 Rh system have been measured in the energy range ≅ 47-85 MeV, using recoil catcher technique followed by off-line gamma-ray spectrometry. Comparison of the experimental data with statistical model based computer code PACE 2 revealed dominance of incomplete fusion in reactions involving alpha-emission channels. To the best of our knowledge these reactions are being reported for the first time

A microRNA, mir133b, suppresses melanopsin expression mediated by failure dopaminergic amacrine cells in RCS rats.

Science.gov (United States)

Li, Yaochen; Li, Chunshi; Chen, Zhongshan; He, Jianrong; Tao, Zui; Yin, Zheng Qin

2012-03-01

The photopigment melanopsin and melanopsin-containing RGCs (mRGCs or ipRGCs) represent a brand-new and exciting direction in the field of visual field. Although the melanopsin is much less sensitive to light and has far less spatial resolution, mRGCs have the unique ability to project to brain areas by the retinohypothalamic tract (RHT) and communicate directly with the brain. Unfortunately, melanopsin presents lower expression levels in many acute and chronic retinal diseases. The molecular mechanisms underlying melanopsin expression are not yet really understood. MicroRNAs play important roles in the control of development. Most importantly, the link of microRNA biology to a diverse set of cellular processes, ranging from proliferation, apoptosis and malignant transformation to neuronal development and fate specification is emerging. We employed Royal College of Surgeon (RCS) rats as animal model to investigate the underlying molecular mechanism regulating melanopsin expression using a panel of miRNA by quantitative real-time reverse transcription polymerase chain reaction. We identified a microRNA, mir133b, that is specifically expressed in retinal dopaminergic amacrine cells as well as markedly increased expression at early stage during retinal degeneration in RCS rats. The overexpression of mir133b downregulates the important transcription factor Pitx3 expression in dopaminergic amacrine cells in RCS rats retinas and makes amacrine cells stratification deficit in IPL. Furthermore, deficient dopaminergic amacrine cells presented decreased TH expression and dopamine production, which lead to a failure to direct mRGCs dendrite to stratify and enter INL and lead to the reduced correct connections between amacrine cells and mRGCs. Our study suggested that overexpression of mir133b and downregulated Pitx3 suppress maturation and function of dopaminergic amacrine cells, and overexpression of mir133b decreased TH and D2 receptor expression as well as dopamine

Daily energy expenditure in free-ranging Gopher Tortoises (Gopherus polyphemus)

NARCIS (Netherlands)

Jodice, PGR; Epperson, DM; Visser, GH

2006-01-01

Studies of ecological energetics in chelonians are rare. Here, we report the first measurements of daily energy expenditure (DEE) and water influx rates (WIRS) in free-ranging adult Gopher Tortoises (Gopherus polyphemus). We used the doubly labeled water (DLW) method to measure DEE in six adult

Prospects for bioenergy use in Ghana using Long-range Energy Alternatives Planning model

International Nuclear Information System (INIS)

Kemausuor, Francis; Nygaard, Ivan; Mackenzie, Gordon

2015-01-01

As Ghana's economy grows, the choice of future energy paths and policies in the coming years will have a significant influence on its energy security. A Renewable Energy Act approved in 2011 seeks to encourage the influx of renewable energy sources in Ghana's energy mix. The new legal framework combined with increasing demand for energy has created an opportunity for dramatic changes in the way energy is generated in Ghana. However, the impending changes and their implication remain uncertain. This paper examines the extent to which future energy scenarios in Ghana could rely on energy from biomass sources, through the production of biogas, liquid biofuels and electricity. Analysis was based on moderate and high use of bioenergy for transportation, electricity generation and residential fuel using the LEAP (Long-range Energy Alternatives Planning) model. Results obtained indicate that introducing bioenergy to the energy mix could reduce GHG (greenhouse gas) emissions by about 6 million tonnes CO_2e by 2030, equivalent to a 14% reduction in a business-as-usual scenario. This paper advocates the use of second generation ethanol for transport, to the extent that it is economically exploitable. Resorting to first generation ethanol would require the allocation of over 580,000 ha of agricultural land for ethanol production. - Highlights: • This paper examines modern bioenergy contribution to Ghana's future energy mix. • Three scenarios are developed and analysed. • Opportunities exist for modern bioenergy to replace carbon intensive fuels. • Introducing modern bioenergy to the mix could result in a 14% reduction in GHG.

Resveratrol-Induced Apoptosis and Increased Radiosensitivity in CD133-Positive Cells Derived From Atypical Teratoid/Rhabdoid Tumor

International Nuclear Information System (INIS)

Kao, C.-L.; Huang, P.-I; Tsai, P.-H.; Tsai, M.-L.; Lo, J.-F.; Lee, Y.-Y.; Chen, Y.-J.; Chen, Y.-W.; Chiou, S.-H.

2009-01-01

Purpose: CD133 has recently been proposed as a marker for cancer stem-like cells (CSC) in brain tumors. The aim of the present study was to investigate the possible role of resveratrol (RV) in radiosensitivity of CD133-positive/-negative cells derived from atypical teratoid/rhabdoid tumors (AT/RT-CD133 +/- ). Materials and Methods: AT/RT-CD133 +/- were isolated and characterized by flow cytometry and quantitative real-time reverse transcription-polymerase chain reaction, and then treated with RV at different doses. Migratory ability, colony formation, apoptotic activity, and xenotransplantation were assessed for RV alone, ionizing radiation (IR) alone, and IR with RV conditions. Results: AT/RT-CD133 + displayed enhanced self-renewal and highly coexpressed 'stem cell' genes and drug-resistant genes, in addition to showing significant resistance to chemotherapeutic agents and radiotherapy as compared with CD133 - cells. After treatment with 200 μM RV, the in vitro proliferation rates and in vivo tumor restoration abilities of ATRT-CD133 + were dramatically inhibited. Importantly, treatment with 150 μM RV can effectively inhibit the expression of drug-resistant genes in AT/RT-CD133 + , and further facilitate to the differentiation of CD133 + into CD133 - . In addition, treatment with 150 μM RV could significantly enhance the radiosensitivity and IR-mediated apoptosis in RV-treated ATRT-CD133 +/- . Kaplan-Meier survival analysis indicated that the mean survival rate of mice with ATRT-CD133 + that were treated with IR could be significantly improved when IR was combined with 150 μM RV treatment. Conclusions: AT/RT-CD133 + exhibit CSC properties and are refractory to IR treatment. Our results suggest that RV treatment plays crucial roles in antiproliferative, proapoptotic, and radiosensitizing effects on treated-CD133 +/- ; RV may therefore improve the clinical treatment of AT/RT.

Correlations between potassium, rubidium and cesium (133Cs and 137Cs) in sporocarps of Suillus variegatus in a Swedish boreal forest

International Nuclear Information System (INIS)

Vinichuk, M.; Rosen, K.; Johanson, K.J.; Dahlberg, A.

2011-01-01

An analysis of sporocarps of ectomycorrhizal fungi Suillus variegatus assessed whether cesium ( 133 Cs and 137 Cs) uptake was correlated with potassium (K) or rubidium (Rb) uptake. The question was whether intraspecific correlations of Rb, K and 133 Cs mass concentrations with 137 Cs activity concentrations in sporocarps were higher within, rather than among, different fungal species, and if genotypic origin of sporocarps within a population affected uptake and correlation. Sporocarps (n = 51) from a Swedish forest population affected by the fallout after the Chernobyl accident were studied. The concentrations were 31.9 ± 6.79 g kg -1 for K (mean ± SD, dwt), 0.40 ± 0.09 g kg -1 for Rb, 8.7 ± 4.36 mg kg -1 for 133 Cs and 63.7 ± 24.2 kBq kg -1 for 137 Cs. The mass concentrations of 133 Cs correlated with 137 Cs activity concentrations (r = 0.61). There was correlation between both 133 Cs concentrations (r = 0.75) and 137 Cs activity concentrations (r = 0.44) and Rb, but the 137 Cs/ 133 Cs isotopic ratio negatively correlated with Rb concentration. Concentrations of K and Rb were weakly correlated (r = 0.51). The 133 Cs mass concentrations, 137 Cs activity concentrations and 137 Cs/ 133 Cs isotopic ratios did not correlate with K concentrations. No differences between, within or, among genotypes in S. variegatus were found. This suggested the relationships between K, Rb, 133 Cs and 137 Cs in sporocarps of S. variegatus is similar to other fungal species. - Highlights: → We studied uptake of Cs ( 133 Cs and 137 Cs), K and Rb by Suillus variegates sporocarps. → Genotypic origin of fungus did not affect uptake of studied elements (isotopes). → Genotypic origin did not affect correlation between Cs ( 133 Cs and 137 Cs), K and Rb.

Study of regional lung function with xenon 133

International Nuclear Information System (INIS)

Devaux, D.; Wagner, R.; Germain, M.; Chardon, G.

1975-01-01

Exploration of regional lung function includes study of the closed circuit perfusion and ventilation respectively by injection and inhalation of xenon 133. The radiation is measured across the chest using 4 fixed scintillation counters, placed opposite the subject's back, 2 per lung field. Theoretical regional values using 15 normal young subjects are determined. Three cases justified the practical interest of this method. The percentage of variation for the parameters studied was about 10%. The method proved very useful for the clinician to whom it provides a numerical assessment of regional ventilation and perfusion [fr

Review of xenon-133 production and related problems; Estudio bibliografico de la produccion de xenon-133 y problemas afines

Energy Technology Data Exchange (ETDEWEB)

Barrachina, M; Ropero, M

1980-07-01

A literature survey is given on the production methods of fission xenon-133 and related problems, such as purification, metrological and dosimetric aspects, preparation of isotopic solutions, recycling, etc. 127 references are included. (Author) 127 refs.

Damage growth in Si during self-ion irradiation: A study of ion effects over an extended energy range

International Nuclear Information System (INIS)

Holland, O.W.; El-Ghor, M.K.; White, C.W.

1989-01-01

Damage nucleation/growth in single-crystal Si during ion irradiation is discussed. For MeV ions, the rate of growth as well as the damage morphology are shown to vary widely along the track of the ion. This is attributed to a change in the dominant, defect-related reactions as the ion penetrates the crystal. The nature of these reactions were elucidated by studying the interaction of MeV ions with different types of defects. The defects were introduced into the Si crystal prior to high-energy irradiation by self-ion implantation at a medium energy (100 keV). Varied damage morphologies were produced by implanting different ion fluences. Electron microscopy and ion-channeling measurements, in conjunction with annealing studies, were used to characterize the damage. Subtle changes in the predamage morphology are shown to result in markedly different responses to the high-energy irradiation, ranging from complete annealing of the damage to rapid growth. These divergent responses occur over a narrow range of dose (2--3 times 10 14 cm -2 ) of the medium-energy ions; this range also marks a transition in the growth behavior of the damage during the predamage implantation. A model is proposed which accounts for these observations and provides insight into ion-induced growth of amorphous layers in Si and the role of the amorphous/crystalline interface in this process. 15 refs, 9 figs

[Overexpressed miRNA-134b inhibits proliferation and invasion of CD133+ U87 glioma stem cells].

Science.gov (United States)

Liu, Yifeng; Zhang, Baochao; Wen, Changming; Wen, Gongling; Zhou, Guoping; Zhang, Jingwei; He, Haifa; Wang, Ning; Li, Wei

2017-05-01

Objective To investigate the role of microRNA-134b (miR-134b) in the tumorigenesis of glioma stem cells (GSCs) and the possible molecular mechanism. Methods Real-time quantitative PCR (qRT-PCR) was used to evalate the expression of miR-134b in CD133 + and CD133 - U87 GSCs. A lentiviral vector overexpressing miR-134b in U87 GSCs was constructed, and the effect of miR-134b overexpression on matrix metalloproteinase-2 (MMP-2), MMP-9 and MMP-12 expressions at both mRNA and protein levels were detected by qRT-PCR and Western blotting, respectively. Transwell TM assay was performed to determine the effect of miR-134b overexpression on GSCs invasion ability. Tumor xenograft models in nude mice were established to evaluate the effect of miR-134b overexpression on tumorgenesis in vivo. Results The qRT-PCR showed that, compared with CD133 - cells, miR-134b was significantly down-regulated in CD133 + cells. Cell line over-expressing miR-134b was successfully established, and miR-134b was up-regulated significantly compared with empty vector control. Overexpression of miR-134b remarkably inhibited the invasion of U87 GSCs and the expression of MMP-12. However, overexpression of miR-134b did not affect MMP-2 and MMP-9 expressions. miR-134b also suppressed U87 GSCs xenograft growth in vivo. Tumor volume in tumor xenograft model group was significantly lower than that in control group, and tumor weight decreased by 42% in the former group. Conclusion Overexpression of miR-134b inhibits the growth and invasion of CD133 + GSCs.

Comparison of 133Xe gas dynamic SPECT and thin-section CT in patients with pulmonary emphysema

International Nuclear Information System (INIS)

Takahashi, Kazue; Satoh, Katashi; Ohkawa, Motoomi

2001-01-01

We assessed 133 Xe gas dynamic single photon emission computed tomography (SPECT) by comparing washout axial images with thin-section CT (TSCT) in patients with pulmonary emphysema. Twenty-three patients were studied. All patients were diagnosed as having pulmonary emphysema on the basis of TSCT. We compared TSCT of upper, middle and lower lung fields with 133 Xe gas dynamic SPECT axial images at the corresponding levels during the 3 to 4 minutes of washout phase. If the degree of 133 Xe gas retention or TSCT finding of ventral and dorsal parts was not the same, the images were divided into two parts. A total of 174 lesions in 23 cases were examined, but 3 lesions having no retention of 133 Xe gas at equilibrium phase were excluded. The results showed that: there were 37 lesions (21.6%) with equivalent severity on both images; there were 42 lesions (24.5%) with more severity on 133 Xe gas dynamic SPECT than on TSCT; and there were 92 lesions (53.8%) with more severity on TSCT than on 133 Xe gas dynamic SPECT. The severity on 133 Xe gas dynamic SPECT and TSCT was not always compatible. One of the reasons for the variable 133 Xe gas retention even when the lesion had the same severity on TSCT, may be bronchial stricture which cannot be seen on TSCT. By comparison of axial images of 133 Xe gas dynamic SPECT with CT images, we could recognize the areas of 133 Xe gas retention in detail. Results suggest that 133 Xe gas dynamic SPECT can be useful to identify ventilation impairment in pulmonary emphysema. (author)

21 CFR 133.146 - Grated cheeses.

Science.gov (United States)

2010-04-01

... Products § 133.146 Grated cheeses. (a) Description. Grated cheeses is the class of foods prepared by..., and skim milk cheese for manufacturing may not be used. All cheese ingredients used are either made... ___ cheese”, the name of the cheese filling the blank. (ii) If only parmesan and romano cheeses are used and...

MicroRNA-133a Inhibits Osteosarcoma Cells Proliferation and Invasion via Targeting IGF-1R

Directory of Open Access Journals (Sweden)

Guangnan Chen

2016-02-01

Full Text Available Background/Aims: MicroRNAs (miRNAs are a class of small noncoding RNAs that regulate gene expression by repressing translation or cleaving RNA transcripts in a sequence-specific manner. Downregulated microRNAs and their roles in cancer development have attracted much attention. A growing body of evidence showed that microRNA-133a (miR-133a has inhibitory effects on cell proliferation, migration, invasion, and metastasis of osteosarcoma. Methods: MiR-133a expression in human osteosarcoma cell lines and human normal osteoblastic cell line hFOB was investigated by real-time PCR (RT-PCR. The role of miR-133a in human osteosarcoma growth and invasion was assessed in cell lines in vitro and in vivo. Then, luciferase reporter assay validated IGF-1R as a downstream and functional target of miR-133a, and functional studies revealed that the anti-tumor effect of miR-133a was probably due to targeting and repressing of IGF-1R expression. Results: MiR-133a was lower expressed in human osteosarcoma cell lines than human normal osteoblastic cell line hFOB and its effect on inhibiting proliferation, invasion and metastasis is mediated by its direct interaction with the IGF-1R. Furthermore, the tumour-suppressive function of miR-133a probably contributed to inhibiting the activation AKT and ERK signaling pathway. Conclusion: MiR-133a suppresses osteosarcoma progression and metastasis by targeting IGF-1R in human osteosarcoma cells, providing a novel candidate prognostic factor and a potential anti-metastasis therapeutic target in osteosarcoma.

Purification, crystallization and preliminary X-ray analysis of a Nup107–Nup133 heterodimeric nucleoporin complex

International Nuclear Information System (INIS)

Boehmer, Thomas; Schwartz, Thomas U.

2007-01-01

A heterodimeric complex consisting of the C-terminal domains of human nucleoporins Nup107 and Nup133 was purified and crystallized and complete diffraction data sets were collected. The nuclear pore complex (NPC), the sole gateway of traffic between the nucleus and the cytoplasm, is built up from multiple copies of about 30 proteins collectively termed nucleoporins (nups). Nups are organized into distinct subcomplexes. Nup107 and Nup133 are members of the essential Nup107–160 subcomplex, a component of the central NPC architecture. A dimeric complex of the C-terminal domains of human Nup107 and Nup133 was expressed from a bicistronic vector in Escherichia coli, purified and crystallized in two different crystal forms. Crystals grown in the presence of 18–22% PEG 3350 belong to space group P2 1 2 1 2 1 and diffracted to 2.9 Å. Native and seleno-l-methionine-derivative crystals grown in the presence of 1.1 M sodium malonate belong to space group C2 and diffracted to 2.55 and 2.9 Å, respectively. Structure determination of this complex will give the first insights into the protein–protein interactions within a core module of the NPC

Purification, crystallization and preliminary X-ray analysis of a Nup107–Nup133 heterodimeric nucleoporin complex

Energy Technology Data Exchange (ETDEWEB)

Boehmer, Thomas; Schwartz, Thomas U., E-mail: tus@mit.edu [Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (United States)

2007-09-01

A heterodimeric complex consisting of the C-terminal domains of human nucleoporins Nup107 and Nup133 was purified and crystallized and complete diffraction data sets were collected. The nuclear pore complex (NPC), the sole gateway of traffic between the nucleus and the cytoplasm, is built up from multiple copies of about 30 proteins collectively termed nucleoporins (nups). Nups are organized into distinct subcomplexes. Nup107 and Nup133 are members of the essential Nup107–160 subcomplex, a component of the central NPC architecture. A dimeric complex of the C-terminal domains of human Nup107 and Nup133 was expressed from a bicistronic vector in Escherichia coli, purified and crystallized in two different crystal forms. Crystals grown in the presence of 18–22% PEG 3350 belong to space group P2{sub 1}2{sub 1}2{sub 1} and diffracted to 2.9 Å. Native and seleno-l-methionine-derivative crystals grown in the presence of 1.1 M sodium malonate belong to space group C2 and diffracted to 2.55 and 2.9 Å, respectively. Structure determination of this complex will give the first insights into the protein–protein interactions within a core module of the NPC.

Xenon-133 hepatic retention ratio: A useful index for fatty liver quantification

International Nuclear Information System (INIS)

Yeh, S.H.; Wu, L.C.; Wang, S.J.; Lin, H.C.; Liu, R.S.; Lee, S.D.; Wu, J.C.

1989-01-01

Xenon-133 hepatic retention ratio was developed for quantifying fatty liver. Data were acquired in frame mode in the hepatic region and both lung bases for 5 min after rebreathing 20 mCi of gaseous 133 Xe and for another 5 min during washout. Static [ 99m Tc]sulfur colloid liver imaging was performed with the patient in the identical position immediately after the ventilation study and data were stored for liver localization. A hepatic time-activity curve corrected for background activity was generated. The 133Xe retention ratio was derived by dividing the activity at 3.5 min after washout by the peak activity. The data of 16 controls and 20 patients with fatty liver were analyzed. The retention ratio (mean +/- s.d.) was greatly increased in patients with fatty infiltration (0.43 +/- 0.20 vs. 0.04 +/- 0.08 in controls, p less than 0.001). There was a strong positive correlation between the 133 Xe retention ratios and percentage of fat on biopsy as assessed by the amount of the liver tissue occupied by fat globules on H ampersand E stained sections. The 133 Xe hepatic retention ratio is a simple, accurate and clinically useful index of detecting, quantifying and managing fatty infiltration of the liver

Theoretical photoionization spectra in the UV photon energy range for a Mg-like Al+ ion

International Nuclear Information System (INIS)

Kim, Dae-Soung; Kim, Young Soon

2008-01-01

In the present work, we report the photoionization cross sections of the Al + ion calculated for the photon energy range 20-26 eV and 30-50 eV. We have expanded our previous calculation (2007 J. Phys. Soc. Japan 76 014302) with an optimized admixture of the initial ground state 3s 21 S and exited states 3s3p 1,3 P, 3s3d 1,3 D and 3s4s 1,3 S, and obtained significantly improved predictions for the main background and autoionizing resonance structures of the reported experimental spectra. The absolute measurements of the photoionization cross sections of the Al + ion in these energy ranges have been performed by West et al (2001 Phys. Rev. A 63 052719), and they reported that the prominent peaks around 21 eV were attributed to the effects of the significant influence of the small fraction of the fourth-order radiation with energies around 84 eV from the synchrotron source. In our previous work, the main shape for these cross sections was calculated assuming an admixture of initial 3s 21 S and 3s3p 3 P states, only with a rough overall estimate for the experimental spectra in the photon energy range 20-26 eV, and without these peaks around 21 eV. The report of the experimental assignment attributes these peaks to the excitation of a 2p electron from the core. However, our present results with the new admixture reveal similar peaks without considering the possibility of the core excitation

Raman, dielectric and variable range hopping nature of Gd2O3-doped K0.5N0.5NbO3 piezoelectric ceramics

Directory of Open Access Journals (Sweden)

Mahesh Peddigari

2015-10-01

Full Text Available (K0.5Na0.5NbO3 (KNN + x wt% Gd2O3 (x = 0 -1.5 ceramics have been prepared by conventional solid state reaction method. The effect of Gd2O3 on the structural, microstructural and dielectric properties of KNN ceramics were studied systematically. The effect of Gd2O3 on phase transformation from orthorhombic to psuedocubic structure is explained interms of changes in the internal vibration modes of NbO6 octahedra. The Raman intensity of the stretching mode v1 enhanced and shifted toward higher wavenumber with Gd2O3 concentration, which is attributed to the increase in polarizability and change in the O-Nb-O bond angles. Microstructural analysis revealed that the grain size of the KNN ceramics decreases from 2.26 ± 1.07 μm to 0.35 ± 0.13 μm and becomes homogenous with an increase in Gd2O3 concentration. The frequency dependent dielectric spectra are analyzed by using Havriliak-Negami function. The fitted symmetry parameter and relaxation time (τ are found to be 0.914 and 8.78 × 10−10 ± 5.5 × 10−11 s, respectively for the sample doped with x = 1.0. The addition of Gd2O3 to the KNN shifted the polymorphic phase transition orthorhombic to tetragonal transition temperature (TO-T from 199oC to 85oC with enhanced dielectric permittivity (ε′ = 1139 at 1 MHz. The sample with x = 1.0, shown a high dielectric permittivity (ε′ = 879 and low dielectric loss (<5% in the broad temperature range (-140oC – 150oC with the Curie temperature 307 oC can have the potential for high temperature piezoelectric and tunable RF circuit applications. The temperature dependent AC-conductivity follows the variable range hopping conduction mechanism by obtaining the slope -0.25 from the ln[ln(ρac] versus ln(T graph in the temperature range of 133 K-308 K. The effect of Gd2O3 on the Mott’s parameters such as density of states (N(EF, hopping length (RH, and hopping energy (WH have been discussed.

The anisotropy of cosmic ray particles in the energy range 1011-1019 eV

International Nuclear Information System (INIS)

Xu Chunxian

1985-01-01

A study of the anisotropy of primary cosmic ray is presented. The expression of the anisotropy is derived in a model of statistical discrete sources in an infinite galaxy. Using these derived formulas, the amplitudes of the first harmonic anisotropies caused by eleven supernovea nearby the Earth are estimated individually and the trend of the resultant anisotropy is investigated. It is found that the expected results can account for the power law of Esup(0.5) of the anisotropy above the energy 5 x 10 15 eV. The Compton-getting effect can cause an additional anisotropy which is independent of energy and added to the resultant anisotropy of these discrete sources. It is apparent that the anisotropies available in the low energy range 10 11 - 10 14 eV are caused by the Compton-Getting effect. Taking the differential spectrum index γ = 2.67 measured in the same energy bound we get the streaming velocity of 35 km/s with respect to the cosmic ray background

Determination of hyperacute kidney rejection in different xenogeneic system by 133xenon washout technique

International Nuclear Information System (INIS)

Welter, H.; Schmidt, K.R.; Pfeifer, K.J.; Hammer, C.; Chaussy, C.

1980-01-01

1. 133 Xenon washout technique is suitable for studying all stages of xenogeneic kidney rejection. 2. Follow-up studies allow differentiation between kidney rejection and kidneys in shock. 3. Changes of intrarenal blood flow distribution correlate with the histologic changes caused by rejection. 4. Total blood flow measurements employing 133 xenon washout yield 10-20% lower values compared with venous outflow measurements. 5. Graft rejection in the xenogeneic cat-dog system can be significantly delayed by ALG pretreatment. 6. The beneficial effect of blood transfusion described in different clinical and experimental studies could not be found after pretreatment of dogs with fox red blood cells. (orig.)

Measurement of neutron activation cross sections in the energy range between 2 and 7 MeV by using a Ti-deuteron target and a deuteron gas target

Energy Technology Data Exchange (ETDEWEB)

Senga, T.; Sakane, H.; Shibata, M.; Yamamoto, H.; Kawade, K. [Nagoya Univ. (Japan); Kasugai, Yoshimi; Ikeda, Yujiro; Takeuchi, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

2000-03-01

Using a Ti-deuteron target in the neutron energy range between 2 and 4.5 MeV and a deuteron gas target between 4.5 and 7 MeV, mono-energetic neutrons could be generated enough for activation cross section measurements. The KN-3750 Van de Grraff accelerator at Nagoya University and the Fusion Neutronics Source (FNS) at Japan Atomic Energy Research Institute (JAERI) were used. Preliminary results of activation cross sections were obtained for reactions of {sup 27}Al(n,p){sup 27}Mg, {sup 47}Ti(n,p){sup 47}Sc, {sup 58}Ni(n,p){sup 58}Co. The evaluation data of JENDL-3.2 showed reasonable agreement with our results. (author)

Partitioning of the nonfixed excess energy and the reverse critical energy in CH2OH + --> CHO + +H2: A classical trajectory study

Science.gov (United States)

Lee, Tae Geol; Kim, Myung Soo; Park, Seung C.

1996-04-01

Dynamics of the four-centered elimination reaction CH2OH+→CHO++H2 has been investigated over the internal energy range 4.6-5.9 eV using the classical trajectory method. A realistic semiempirical potential reported previously [J. Chem. Phys. (in press, 1996)] has been used for the calculation. It has been found that the disposal of the nonfixed excess energy at the transition state and of the reverse critical energy can be considered independently as manifest in the sum rule analysis. The former is determined statistically while the latter dynamically. Based on the above idea, a method to determine the kinetic energy release distribution originating only from the reverse critical energy has been developed.

A distance of 133-137 parsecs to the Pleiades star cluster.

Science.gov (United States)

Pan, Xiaopei; Shao, M; Kulkarni, S R

2004-01-22

Nearby 'open' clusters of stars (those that are not gravitationally bound) have played a crucial role in the development of stellar astronomy because, as a consequence of the stars having a common age, they provide excellent natural laboratories to test theoretical stellar models. Clusters also play a fundamental part in determining distance scales. The satellite Hipparcos surprisingly found that an extensively studied open cluster--the Pleiades (also known as the Seven Sisters)--had a distance of D = 118 +/- 4 pc (refs 2, 3), about ten per cent smaller than the accepted value. The discrepancy generated a spirited debate because the implication was that either current stellar models were incorrect by a surprising amount or Hipparcos was giving incorrect distances. Here we report the orbital parameters of the bright double star Atlas in the Pleiades, using long-baseline optical/infrared interferometry. From the data we derive a firm lower bound of D > 127 pc, with the most likely range being 133 < D < 137 pc. Our result reaffirms the fidelity of current stellar models.

Energy supply modelling of a low-CO 2 emitting energy system: Case study of a Danish municipality

DEFF Research Database (Denmark)

Sveinbjörnsson, Dadi Þorsteinn; Ben Amer-Allam, Sara; Hansen, Anders Bavnhøj

2017-01-01

Municipal activities play an important role in national and global CO2-emission reduction efforts, with Nordic countries at the forefront thanks to their energy planning tradition and high penetration of renewable energy sources. In this work, we present a case study of the Danish municipality...... dependent on changes in energy prices.We conclude that in order to achieve their CO2 emission goals in the most energy-efficient, cost-effective and sustainable way, municipalities similar to Sønderborg should compare a wide range of energy system configurations, for example, scenarios with a high degree...

Energy of nuclear-active particles in the 1-50 TeV energy range

International Nuclear Information System (INIS)

Kotlyarevskij, D.M.; Garsevanishvili, L.P.; Morozov, I.V.

1979-01-01

The ''TsKhRA-TsKARO'' installation designed for the investigation of cosmic beams interaction with nuclei in the energy range of 1-50 TeV is described. The installation comprises a magnetic spark spectrometer, photography system, ionization calorimeter and scintillating trigger device. The ionization calorimeter contains 12 rows of ionization chambers interlayed with 4 lead and 8 iron absorbers. The rows of ionization chambers of the calorimeter upper half are placed in the mutually-perpendicular direction to restore the direction and spatial situation of the electron-nuclear cascade. All in all the ionization calorimeter contains 100 channels of preintensifiers from which the information is transmitted to the terminal intensifiers and then to the storage cells. The aperture ratio of the whole installation (taking account of the upper chambers) is 0.5 m 2 /steradian, and the aperture ratio of the calorimeter together with the lower chambers is approximately 2 m 2 /steradian. Presented are integral spectra of the hadrons at the height of mountains and at the height of 2500 m above sea level obtained with the help of the installation described. Comparison of the number of charged and neutral particles recorded with the ''TsKhRA-TsKARO'' installation agrees well with the known ratio of charged and neutral cosmic hadrons on the heights of mountains n/c = 0.52+-0.05

21 CFR 133.118 - Colby cheese.

Science.gov (United States)

2010-04-01

... coloring may be added. Sufficient rennet, or other safe and suitable milk-clotting enzyme that produces... of enzymes of animal or plant origin capable of aiding in the curing or development of flavor of.../catalase as provided in § 133.113(a)(3). (d)(1) Colby cheese in the form of slices or cuts may have added...

21 CFR 133.169 - Pasteurized process cheese.

Science.gov (United States)

2010-04-01

...) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.169 Pasteurized process cheese. (a)(1) Pasteurized process cheese is... two or more varieties, except cream cheese, neufchatel cheese, cottage cheese, lowfat cottage cheese...

Fragrance material review on 1-(3,3-dimethylcyclohexyl)pent-4-en-1-one.

Science.gov (United States)

Scognamiglio, J; Letizia, C S; Api, A M

2013-12-01

A toxicologic and dermatologic review of 1-(3,3-dimethylcyclohexyl)pent-4-en-1-one when used as a fragrance ingredient is presented. 1-(3,3-Dimethylcyclohexyl)pent-4-en-1-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1-(3,3-dimethylcyclohexyl)pent-4-en-1-one were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, elicitation, repeated dose, and genotoxicity data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A toxicologic and dermatologic assessment of alkyl cyclic ketones when used as fragrance ingredients (submitted for publication) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances. Copyright © 2013 Elsevier Ltd. All rights reserved.

Photofragmentation spectra of halogenated methanes in the VUV photon energy range

Energy Technology Data Exchange (ETDEWEB)

Cartoni, Antonella, E-mail: antonella.cartoni@uniroma1.it [Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P.le Aldo Moro 5, Roma 00185 (Italy); Bolognesi, Paola; Fainelli, Ettore; Avaldi, Lorenzo [CNR-IMIP, Area della Ricerca di Roma 1, Monterotondo Scalo (Rm) 00015 (Italy)

2014-05-14

In this paper an investigation of the photofragmentation of dihalomethanes CH{sub 2}X{sub 2} (X = F, Cl, Br, I) and chlorinated methanes (CH{sub n}Cl{sub 4−n} with n = 0–3) with VUV helium, neon, and argon discharge lamps is reported and the role played by the different halogen atoms is discussed. Halogenated methanes are a class of molecules used in several fields of chemistry and the study of their physical and chemical proprieties is of fundamental interest. In particular their photodissociation and photoionization are of great importance since the decomposition of these compounds in the atmosphere strongly affects the environment. The results of the present work show that the halogen-loss is the predominant fragmentation channel for these molecules in the VUV photon energy range and confirm their role as reservoir of chlorine, bromine, and iodine atoms in the atmosphere. Moreover, the results highlight the peculiar feature of CH{sub 2}F{sub 2} as a source of both fluorine and hydrogen atoms and the characteristic formation of I{sub 2}{sup +} and CH{sub 2}{sup +} ions from the photofragmentation of the CH{sub 2}I{sub 2} molecule.

Performance tests of a special ionization chamber for X-rays in mammography energy range

Energy Technology Data Exchange (ETDEWEB)

Silva, J.O., E-mail: jonas.silva@ufg.br [Universidade Federal de Goiás (UFG), Goiânia (Brazil). Instituto de Física; Caldas, L.V.E. [Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP), São Paulo, SP (Brazil). Centro de Metrologia das Radiações

2017-07-01

A special mammography homemade ionization chamber was developed to be applied for mammography energy range dosimetry. This chamber has a total sensitive volume of 6 cm{sup 3} and is made of a PMMA body and graphite coated collecting electrode. Performance tests as saturation, ion collection efficiency, linearity of chamber response versus air kerma rate and energy dependence were determined. The results obtained with this special homemade ionization chamber are within the limits stated in international recommendations. This chamber can be used in quality control programs of mammography energy range. All measurements were carried out at the Calibration Laboratory of IPEN. (author)

Federal R&D Agenda for Net Zero Energy, High-Performance Green Buildings

Science.gov (United States)

2008-09-30

Source: 2007 DOE Buildings Energy Data Book . Tables 1.1.3, 1.2.3, 1.3.3 Energy consumption associated with buildings has a substantial impact on...from poor indoor air quality (IAQ) include Legionnaire’s disease, heart disease and lung cancer from secondhand smoke, and carbon monoxide poisoning...publications/pdfs/highperformance/commercialbuildi ngsroadmap.pdf DOE. 2007a. Buildings energy data book . http://buildingsdatabook.eren.doe.gov/ DOE

Energy and exergy prices of various energy sources along with their CO2 equivalents

International Nuclear Information System (INIS)

Caliskan, Hakan; Hepbasli, Arif

2010-01-01

Various types of energy sources are used in the residential and industrial sectors. Choosing the type of sources is important. When an energy source is selected, its CO 2 equivalent and energy and exergy prices must be known for a sustainable future and for establishing energy policies. These prices are based on their energy values. Exergy analysis has been recently applied to a wide range of energy-related systems. Thus, obtaining the exergy values has become more meaningful for long-term planning. In this study, energy and exergy prices of various energy sources along with CO 2 equivalents are calculated and compared for residential and industrial applications in Turkey. Energy sources considered include coal, diesel oil, electricity, fuel oil, liquid petroleum gas (LPG), natural gas, heat pumps and geothermal, and their prices were obtained over a period of 18 months, from January 2008 to June 2009. For the residential and industrial sectors, minimum energy and exergy prices were found for ground source heat pumps, while maximum energy and exergy prices belong to LPG for both sectors.

Xe-133 recuperation by adsorption in active carbon impregnated with PF5

International Nuclear Information System (INIS)

Mondino, A.V.; Marques, R.O.

1990-01-01

Since the Mo-99 Fission Project has the aim to produce Xe-133 from gases generated in the alkaline dissolution of Al-U plates irradiated with thermal neutrons and, considering the importance of this radioisotope from the nuclear medicine point of view, studies to improve and optimize the Xe-133 recuperation were continued. Experiences were made on 'static' equilibrium employing high purity xenon and for the 'dynamic' case, Xe-133 mixed with a carrier and nitrogen as gas carrier; in this case, a 44% and a 34% increase in the capacity of xenon adsorption relaxed with activated carbon without being impregnated and impregnated with AgF, were respectively achieved. (Author) [es

Metrological activity determination of {sup 133}Ba by sum-peak absolute method

Energy Technology Data Exchange (ETDEWEB)

Silva, R.L. da; Delgado, J.U.; Poledna, R.; Santos, A.; Veras, E.V. de; Rangel, J.; Trindade, O.L. [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Almeida, M.C.M. de, E-mail: marcandida@yahoo.com.br, E-mail: candida@cnen.gov.br [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)

2015-07-01

The National Laboratory for Metrology of Ionizing Radiation provides gamma sources of radionuclide and standardized in activity with reduced uncertainties. Relative methods require standards to determine the sample activity while the absolute methods, as sum-peak, not. The activity is obtained directly with good accuracy and low uncertainties. {sup 133}Ba is used in research laboratories and on calibration of detectors for analysis in different work areas. Classical absolute methods do not calibrate {sup 133}Ba due to its complex decay scheme. The sum-peak method using gamma spectrometry with germanium detector standardizes {sup 133}Ba samples. Uncertainties lower than 1% to activity results were obtained.

CD133+CD24lo defines a 5-Fluorouracil-resistant colon cancer stem cell-like phenotype

Science.gov (United States)

Paschall, Amy V.; Yang, Dafeng; Lu, Chunwan; Redd, Priscilla S.; Choi, Jeong-Hyeon; Heaton, Christopher M.; Lee, Jeffrey R.; Nayak-Kapoor, Asha; Liu, Kebin

2016-01-01

The chemotherapeutic agent 5-Fluorouracil (5-FU) is the most commonly used drug for patients with advanced colon cancer. However, development of resistance to 5-FU is inevitable in almost all patients. The mechanism by which colon cancer develops 5-FU resistance is still unclear. One recently proposed theory is that cancer stem-like cells underlie colon cancer 5-FU resistance, but the phenotypes of 5-FU-resistant colon cancer stem cells are still controversial. We report here that 5-FU treatment selectively enriches a subset of CD133+ colon cancer cells in vitro. 5-FU chemotherapy also increases CD133+ tumor cells in human colon cancer patients. However, sorted CD133+ colon cancer cells exhibit no increased resistance to 5-FU, and CD133 levels exhibit no correlation with colon cancer patient survival or cancer recurrence. Genome-wide analysis of gene expression between sorted CD133+ colon cancer cells and 5-FU-selected colon cancer cells identifies 207 differentially expressed genes. CD24 is one of the genes whose expression level is lower in the CD133+ and 5-FU-resistant colon cancer cells as compared to CD133+ and 5-FU-sensitive colon cancer cells. Consequently, CD133+CD24lo cells exhibit decreased sensitivity to 5-FU. Therefore, we determine that CD133+CD24lo phenotype defines 5-FU-resistant human colon cancer stem cell-like cells. PMID:27659530

Analyzing power of inclusive production of π+,π-, and KS0 by polarized protons at 13.3 and 18.5 GeV/c

International Nuclear Information System (INIS)

Bonner, B.E.; Buchanan, J.A.; Clement, J.M.; Corcoran, M.D.; Krishna, N.M.; Kruk, J.W.; Miettinen, H.E.; Moss, R.M.; Mutchler, G.S.; Nessi-Tedaldi, F.; Nessi, M.; Phillips, G.C.; Roberts, J.B.; Stevenson, P.M.; Tonse, S.R.; Birman, A.; Chung, S.U.; Etkin, A.; Fernow, R.C.; Kirk, H.; Protopopescu, S.D.; Willutzki, H.; Hallman, T.; Madansky, L.; Bar-Yam, Z.; Dowd, J.; Kern, W.; King, E.; Mayes, B.W.; Pinsky, L.S.

1990-01-01

We have measured the analyzing power in π + , π - , and K S 0 production by a polarized proton beam at 13.3 and 18.5 GeV/c. The data cover the central and the beam fragmentation region, in the transverse-momentum range up to 2 GeV/c. The results indicate that sizable effects are present at high x F and also persist into the hard-scattering region for K S 0 and π + . A zero value of the analyzing power was observed for π - production

High energy storage density over a broad temperature range in sodium bismuth titanate-based lead-free ceramics.

Science.gov (United States)

Yang, Haibo; Yan, Fei; Lin, Ying; Wang, Tong; Wang, Fen

2017-08-18

A series of (1-x)Bi 0.48 La 0.02 Na 0.48 Li 0.02 Ti 0.98 Zr 0.02 O 3 -xNa 0.73 Bi 0.09 NbO 3 ((1-x)LLBNTZ-xNBN) (x = 0-0.14) ceramics were designed and fabricated using the conventional solid-state sintering method. The phase structure, microstructure, dielectric, ferroelectric and energy storage properties of the ceramics were systematically investigated. The results indicate that the addition of Na 0.73 Bi 0.09 NbO 3 (NBN) could decrease the remnant polarization (P r ) and improve the temperature stability of dielectric constant obviously. The working temperature range satisfying TCC 150  °C  ≤±15% of this work spans over 400 °C with the compositions of x ≥ 0.06. The maximum energy storage density can be obtained for the sample with x = 0.10 at room temperature, with an energy storage density of 2.04 J/cm 3 at 178 kV/cm. In addition, the (1-x)LLBNTZ-xNBN ceramics exhibit excellent energy storage properties over a wide temperature range from room temperature to 90 °C. The values of energy storage density and energy storage efficiency is 0.91 J/cm 3 and 79.51%, respectively, for the 0.90LLBNTZ-0.10NBN ceramic at the condition of 100 kV/cm and 90 °C. It can be concluded that the (1-x)LLBNTZ-xNBN ceramics are promising lead-free candidate materials for energy storage devices over a broad temperature range.

[The expression and significance of CD(276) and CD(133) in colorectal cancer and precancerous lesions].

Science.gov (United States)

Lu, G F; Huang, L N; Ren, J L; Hu, G M; Zheng, Z H; Wu, J X; Zhu, Y P; Tang, F A

2018-06-01

In order to study the significance of CD(276) and CD(133) in the development and progression of colorectal cancer (CRC), the expression of CD(276) and CD(133) was detected by immunohistochemistry in CRC and precancerous lesions. The results showed that the intensity of CD(276) and CD(133) in CRC samples was higher than that in adenoma group and non-adenoma group. CD(276) and CD(133) single and double positive expression were significantly correlated with CRC lymph node metastasis, distant metastasis and survival. CD(276) and CD(133) are significantly correlated to the development and progression of CRC and associated with poor prognosis.

Ultraviolet-induced cutaneous hyperemia and steroid-induced cutaneous hypoemia measured by 133Xe disappearance in dogs

International Nuclear Information System (INIS)

Chimoskey, J.E.; Flanagan, W.

1974-01-01

133 Xe disappearance rates in dog skin were determined by injection of 100 μc 133 Xe dissolved in 0.025 ml physiologic saline solution into the skin with a 30-gauge needle and external detection of gamma radiation with a 2-inch sodium iodide crystal, photomultiplier, rate meter, and timer-scaler system. Skin temperature was measured by a thermistor. Skin blood flow was manipulated by the topical application of fluocinolone acetonide and by ultraviolet radiation. Fluocinolone acetonide caused significant reduction of skin blood flow, and ultraviolet irradiation caused significant increase in skin blood flow

Decreased 133Xe clearance in the proximal femur in acromegaly

International Nuclear Information System (INIS)

Kapitola, J.; Marek, J.; Jahoda, I.; Vilimovska, D.

1986-01-01

Using the 133 Xe tissue clearance method, the blood flow in the greater trochanter of the femur was studied in 30 patients with acromegaly. Both the washout rate constant (k 2 ) and blood flow (P 2 ) values are significantly decreased in acromegaly (p < 0.01). There is a significant negative correlation (r = -0.42, p < 0.05) between the flow values and mean daily concentrations of growth hormone in serum of acromegalic patients. The observation is presented as a preliminary evidence of a possible influence of growth hormone on the blood flow in bone. (author)

Multilayer optics for monochromatic high-resolution X-ray imaging diagnostic in a broad photon energy range from 2 keV to 22 keV

International Nuclear Information System (INIS)

Troussel, Ph.; Dennetiere, D.; Maroni, R.; Høghøj, P.; Hedacq, S.; Cibik, L.; Krumrey, M.

2014-01-01

The “Commissariat à l’énergie atomique et aux énergies alternatives” (CEA) studies and designs advanced X-ray diagnostics to probe dense plasmas produced at the future Laser MegaJoule (LMJ) facility. Mainly for X-ray imaging with high spatial resolution, different types of multilayer mirrors were developed to provide broadband X-ray reflectance at grazing incidence. These coatings are deposited on two toroidal mirror substrates that are then mounted into a Wolter-type geometry (working at a grazing angle of 0.45°) to realize an X-ray microscope. Non-periodic (depth graded) W/Si multilayer can be used in the broad photon energy range from 2 keV to 22 keV. A third flat mirror can be added for the spectral selection of the microscope. This mirror is coated with a Mo/Si multilayer for which the d-spacing varies in the longitudinal direction to satisfy the Bragg condition within the angular acceptance of the microscope and also to compensate the angular dispersion due to the field of the microscope. We present a study of such a so-called Göbel mirror which was optimized for photon energy of 10.35 keV. The three mirrors were coated using magnetron sputtering technology by Xenocs SA. The reflectance in the entire photon energy range was determined in the laboratory of the Physikalisch-Technische Bundesanstalt (PTB) at the synchrotron radiation facility BESSY II in Berlin

Multilayer optics for monochromatic high-resolution X-ray imaging diagnostic in a broad photon energy range from 2 keV to 22 keV

Energy Technology Data Exchange (ETDEWEB)

Troussel, Ph., E-mail: philippe.troussel@cea.fr [CEA, DAM, DIF, F-91297 Arpajon (France); Dennetiere, D. [Synchrotron Soleil, L’orme des Merisiers, 91190 Saint-Aubin (France); Maroni, R. [CEA, DAM, DIF, F-91297 Arpajon (France); Høghøj, P.; Hedacq, S. [Xenocs SA, 19, rue François Blumet, F-38360 Sassenage (France); Cibik, L.; Krumrey, M. [Physikalisch-Technische Bundesanstalt (PTB), Abbestr. 2-12, 10587 Berlin (Germany)

2014-12-11

The “Commissariat à l’énergie atomique et aux énergies alternatives” (CEA) studies and designs advanced X-ray diagnostics to probe dense plasmas produced at the future Laser MegaJoule (LMJ) facility. Mainly for X-ray imaging with high spatial resolution, different types of multilayer mirrors were developed to provide broadband X-ray reflectance at grazing incidence. These coatings are deposited on two toroidal mirror substrates that are then mounted into a Wolter-type geometry (working at a grazing angle of 0.45°) to realize an X-ray microscope. Non-periodic (depth graded) W/Si multilayer can be used in the broad photon energy range from 2 keV to 22 keV. A third flat mirror can be added for the spectral selection of the microscope. This mirror is coated with a Mo/Si multilayer for which the d-spacing varies in the longitudinal direction to satisfy the Bragg condition within the angular acceptance of the microscope and also to compensate the angular dispersion due to the field of the microscope. We present a study of such a so-called Göbel mirror which was optimized for photon energy of 10.35 keV. The three mirrors were coated using magnetron sputtering technology by Xenocs SA. The reflectance in the entire photon energy range was determined in the laboratory of the Physikalisch-Technische Bundesanstalt (PTB) at the synchrotron radiation facility BESSY II in Berlin.

Multilayer optics for monochromatic high-resolution X-ray imaging diagnostic in a broad photon energy range from 2 keV to 22 keV

Science.gov (United States)

Troussel, Ph.; Dennetiere, D.; Maroni, R.; Høghøj, P.; Hedacq, S.; Cibik, L.; Krumrey, M.

2014-12-01

The "Commissariat à l'énergie atomique et aux énergies alternatives" (CEA) studies and designs advanced X-ray diagnostics to probe dense plasmas produced at the future Laser MegaJoule (LMJ) facility. Mainly for X-ray imaging with high spatial resolution, different types of multilayer mirrors were developed to provide broadband X-ray reflectance at grazing incidence. These coatings are deposited on two toroidal mirror substrates that are then mounted into a Wolter-type geometry (working at a grazing angle of 0.45°) to realize an X-ray microscope. Non-periodic (depth graded) W/Si multilayer can be used in the broad photon energy range from 2 keV to 22 keV. A third flat mirror can be added for the spectral selection of the microscope. This mirror is coated with a Mo/Si multilayer for which the d-spacing varies in the longitudinal direction to satisfy the Bragg condition within the angular acceptance of the microscope and also to compensate the angular dispersion due to the field of the microscope. We present a study of such a so-called Göbel mirror which was optimized for photon energy of 10.35 keV. The three mirrors were coated using magnetron sputtering technology by Xenocs SA. The reflectance in the entire photon energy range was determined in the laboratory of the Physikalisch-Technische Bundesanstalt (PTB) at the synchrotron radiation facility BESSY II in Berlin.

A method for determining leakage of 133Xe gas from septum-sealed glass vials

International Nuclear Information System (INIS)

McAllister, J.R.; Borak, T.B.; Pellicciarini, D.W.

2000-01-01

The authors have developed a method for determining the leakage of 133 Xe gas from septum-sealed glass vials that are supplied for medical examinations. Twenty vials each originally containing 370 MPq of 133 Xe and 20 vials each originally containing 740 MBq 133 Xe were measured daily for 26 d. Retention of 133 Xe within the vial was modeled as a first order process with a constant rate coefficient, λ T . The value of λ T was estimated for each vial using a regression analysis. The leakage rate, λ L , was then determined assuming that λ L = λ L + λ r where λ r represents the physical decay of 133 Xe. Monte Carlo simulations were performed using uncertainties in the estimates of each vial to obtain the mean and tails of the distribution for the average leakage rate, bar λ L . the average leakage rate for the complete sample of vials was 0.00007 d -1 with an upper, one-sided, 95% confidence limit of 0.0011 d -1 . Uncertainties in the published values of λ r for 133 Xe made a significant contribution to the uncertainties of the leakage rate for this sample of vials. The methods described can be applied to other situations where leakage of radioactive materials may be of concern

Energy development and CO2 emissions in China

International Nuclear Information System (INIS)

Xiaolin Xi

1993-03-01

The objective of this research is to provide a better understanding of future Chinese energy development and CO 2 emissions from burning fossil fuels. This study examines the current Chinese energy system, estimates CO 2 emissions from burning fossil fuels and projects future energy use and resulting CO 2 emissions up to the year of 2050. Based on the results of the study, development strategies are proposed and policy implications are explored. This study first develops a Base scenario projection of the Chinese energy development based upon a sectoral analysis. The Base scenario represents a likely situation of future development, but many alternatives are possible. To explore this range of alternatives, a systematic uncertainty analysis is performed. The Base scenario also represents an extrapolation of current policies and social and economic trends. As such, it is not necessarily the economically optimal future course for Chinese energy development. To explore this issue, an optimization analysis is performed. For further understanding of developing Chinese energy system and reducing CO 2 emissions, a Chinese energy system model with 84 supply and demand technologies has been constructed in MARKAL, a computer LP optimization program for energy systems. Using this model, various technological options and economic aspects of energy development and CO 2 emissions reduction in China during the 1985-2020 period are examined

CD133 Modulate HIF-1α Expression under Hypoxia in EMT Phenotype Pancreatic Cancer Stem-Like Cells

Directory of Open Access Journals (Sweden)

Koki Maeda

2016-06-01

Full Text Available Although CD133 is a known representative cancer stem cell marker, its function in tumor aggressiveness under hypoxia is not fully known. The aim of this study is to demonstrate that CD133 regulates hypoxia inducible factor (HIF-1α expression with tumor migration. The CD133+ pancreatic cancer cell line, Capan1M9, was compared with the CD133− cell line, shCD133M9, under hypoxia. HIF-1α expression levels were compared by Western blot, HIF-1α nucleus translocation assay and real-time (RT-PCR. The hypoxia responsive element (HRE was observed by luciferase assay. The migration ability was analyzed by migration and wound healing assays. Epithelial mesenchymal transition (EMT related genes were analyzed by real-time RT-PCR. HIF-1α was highly expressed in Capan1M9 compared to shCD133M9 under hypoxia because of the high activation of HRE. Furthermore, the migration ability of Capan1M9 was higher than that of shCD133M9 under hypoxia, suggesting higher expression of EMT related genes in Capan1M9 compared to shCD133M9. Conclusion: HIF-1α expression under hypoxia in CD133+ pancreatic cancer cells correlated with tumor cell migration through EMT gene expression. Understanding the function of CD133 in cancer aggressiveness provides a novel therapeutic approach to eradicate pancreatic cancer stem cells.

Energy booklet. Part 2. Energy saving tips for more pocket money and environment; EnergieFibel. Heft 2. EnergieSparTipps fuer mehr Taschengeld und Umwelt

Energy Technology Data Exchange (ETDEWEB)

NONE

2009-07-01

The effective environmental protection begins when saving. Energy which is not used at all also cannot burden the environment. Pleasant side effect: also the purse is treated gently. One of the most important measures for the reduction of energy consumption is the correct thermal insulation of a building so that heating energy cannot escape unused in the free. Thus, between 50 and 75 per cent of energy can be saved. Investments within this range usually are profitable already after a short time. The utilization of damming materials from regenerative raw materials enables application of financial incentives. In addition, within other ranges of the house modernizations and a change of the behaviour of utilization help to save energy. The contribution under consideration gives advices in order to improve dwellings energy-technically. The environment and the purse will thank it.

15q13.3 homozygous knockout mouse model display epilepsy-, autism- and schizophrenia-related phenotypes

DEFF Research Database (Denmark)

Forsingdal, A; Fejgin, Kim; Nielsen, Viggo

2016-01-01

The 15q13.3 microdeletion syndrome is caused by a 1.5-MB hemizygous microdeletion located on 15q13.3 affecting seven genes: FAN1; MTMR10; TRPM1; miR-211; KLF13; OTUD7A; and CHRNA7. The 15q13.3 microdeletion increases the risk of intellectual disability, epilepsy, autism spectrum disorder...

XENON-133 IN CALIFORNIA, NEVADA, AND UTAH FROM THE CHERNOBYL ACCIDENT (JOURNAL VERSION)

Science.gov (United States)

The accident at the Chernobyl nuclear reactor in the USSR introduced numerous radioactive nuclides into the atmosphere, including the noble gas xenon-133. EPA's Environmental Monitoring Systems Laboratory, Las Vegas, NV, detected xenon-133 from the Chernobyl accident in air sampl...

Vertical detachment energies of anionic thymidine: Microhydration effects.

Science.gov (United States)

Kim, Sunghwan; Schaefer, Henry F

2010-10-14

Density functional theory has been employed to investigate microhydration effects on the vertical detachment energy (VDE) of the thymidine anion by considering the various structures of its monohydrates. Structures were located using a random searching procedure. Among 14 distinct structures of the anionic thymidine monohydrate, the low-energy structures, in general, have the water molecule bound to the thymine base unit. The negative charge developed on the thymine moiety increases the strength of the intermolecular hydrogen bonding between the water and base units. The computed VDE values of the thymidine monohydrate anions are predicted to range from 0.67 to 1.60 eV and the lowest-energy structure has a VDE of 1.32 eV. The VDEs of the monohydrates of the thymidine anion, where the N(1)[Single Bond]H hydrogen of thymine has been replaced by a 2(')-deoxyribose ring, are greater by ∼0.30 eV, compared to those of the monohydrates of the thymine anion. The results of the present study are in excellent agreement with the accompanying experimental results of Bowen and co-workers [J. Chem. Phys. 133, 144304 (2010)].

Report of the subpanel on long-range planning for the US High-Energy-Physics Program of the High-Energy-Physics Advisory Panel

International Nuclear Information System (INIS)

1982-01-01

The US High Energy Program remains strong, but it faces vigorous competition from other regions of the world. To maintain its vitality and preeminence over the next decade it requires the following major ingredients: (1) strong exploitation of existing facilities; (2) the expeditious completion of construction projects which will expand these facilities over the next few years; (3) the construction of a substantial new facility to be ready for research by the end of the 1980's; and (4) the vigorous pursuit of a wide range of advanced accelerator R and D programs in preparation for the design and construction of a higher energy accelerator which would probably be initiated near the end of this decade. The Subpanel has considered how best to accomplish these goals under two different budgetary assumptions; namely, average yearly support levels of $440M DOE, $35M NSF, and $395M DOE, $34M NSF (FY 1982 dollars). It has also considered the impact of a yet lower support level of $360M DOE and $32M NSF. A description of facilities in high energy physics is given, and facility recommendations and long range plans are discussed. Recommendations for international collaboration are included

Regional cerebral blod flow studied by xenon-133. Intra-arterial injection studies and inhalation studies using emission tomography

DEFF Research Database (Denmark)

Lassen, N A

1980-01-01

.) technique is insensitive both to hyperemia and ischemia yielding essentially only a mean flow value. A new rapidly moving single photon tomograph following D. Kuhl's principle is presented applicable to Xe-133. Preliminary clinical data show that this technique is able to detect ischemic areas both with Xe......A survey of the Xenon-133 techniques for measurement of regional cerebral blood flow, rCBF, in man is presented. The intra-arterial Xe-133 injection method is very sensitive for detecting even small hyperemic areas, but cannot "see" smaller ischemic areas. The Xe-133 inhalation (or i.v. inj......-133 intra-arterial injection and with Xe-133 inhalation. The practical and economic advantages of Xe-133 or Xe-127 tomography over positron tomography for rCBF are discussed....

The role of CD133 in normal human prostate stem cells and malignant cancer-initiating cells.

Science.gov (United States)

Vander Griend, Donald J; Karthaus, Wouter L; Dalrymple, Susan; Meeker, Alan; DeMarzo, Angelo M; Isaacs, John T

2008-12-01

Resolving the specific cell of origin for prostate cancer is critical to define rational targets for therapeutic intervention and requires the isolation and characterization of both normal human prostate stem cells and prostate cancer-initiating cells (CIC). Single epithelial cells from fresh normal human prostate tissue and prostate epithelial cell (PrEC) cultures derived from them were evaluated for the presence of subpopulations expressing stem cell markers and exhibiting stem-like growth characteristics. When epithelial cell suspensions containing cells expressing the stem cell marker CD133+ are inoculated in vivo, regeneration of stratified human prostate glands requires inductive prostate stromal cells. PrEC cultures contain a small subpopulation of CD133+ cells, and fluorescence-activated cell sorting-purified CD133+ PrECs self-renew and regenerate cell populations expressing markers of transit-amplifying cells (DeltaNp63), intermediate cells (prostate stem cell antigen), and neuroendocrine cells (CD56). Using a series of CD133 monoclonal antibodies, attachment and growth of CD133+ PrECs requires surface expression of full-length glycosylated CD133 protein. Within a series of androgen receptor-positive (AR+) human prostate cancer cell lines, CD133+ cells are present at a low frequency, self-renew, express AR, generate phenotypically heterogeneous progeny negative for CD133, and possess an unlimited proliferative capacity, consistent with CD133+ cells being CICs. Unlike normal adult prostate stem cells, prostate CICs are AR+ and do not require functional CD133. This suggests that (a) AR-expressing prostate CICs are derived from a malignantly transformed intermediate cell that acquires "stem-like activity" and not from a malignantly transformed normal stem cell and (b) AR signaling pathways are a therapeutic target for prostate CICs.

Charge-transfer cross sections of ground state He+ ions in collisions with He atoms and simple molecules in the energy range below 4.0 keV

International Nuclear Information System (INIS)

Kusakabe, Toshio; Kitamuro, Satoshi; Nakai, Yohta; Tawara, Hiroyuki; Sasao, Mamiko

2012-01-01

Charge-transfer cross sections of the ground state He + ions in collisions with He atoms and simple molecules (H 2 , D 2 , N 2 , CO and CO 2 ) have been measured in the energy range of 0.20 to 4.0 keV with the initial growth rate method. Since previously published experimental data are scattered in the low energy region, the present observations would provide reasonably reliable cross section data below 4 keV. The charge transfer accompanied by dissociation of product molecular ion can be dominant at low energies for molecular targets. In He + + D 2 collisions, any isotope effect was not observed over the present energy range, compared to H 2 molecule. (author)

Optimized high energy resolution in γ-ray spectroscopy with AGATA triple cluster detectors

Energy Technology Data Exchange (ETDEWEB)

Wiens, Andreas

2011-06-20

The AGATA demonstrator consists of five AGATA Triple Cluster (ATC) detectors. Each triple cluster detector contains three asymmetric, 36-fold segmented, encapsulated high purity germanium detectors. The purpose of the demonstrator is to show the feasibility of position-dependent γ-ray detection by means of γ-ray tracking, which is based on pulse shape analysis. The thesis describes the first optimization procedure of the first triple cluster detectors. Here, a high signal quality is mandatory for the energy resolution and the pulse shape analysis. The signal quality was optimized and the energy resolution was improved through the modification of the electronic properties, of the grounding scheme of the detector in particular. The first part of the work was the successful installation of the first four triple cluster detectors at INFN (National Institute of Nuclear Physics) in Legnaro, Italy, in the demonstrator frame prior to the AGATA commissioning experiments and the first physics campaign. The four ATC detectors combine 444 high resolution spectroscopy channels. This number combined with a high density were achieved for the first time for in-beam γ-ray spectroscopy experiments. The high quality of the ATC detectors is characterized by the average energy resolutions achieved for the segments of each crystal in the range of 1.943 and 2.131 keV at a γ-ray energy of 1.33 MeV for the first 12 crystals. The crosstalk level between individual detectors in the ATC is negligible. The crosstalk within one crystal is at a level of 10{sup -3}. In the second part of the work new methods for enhanced energy resolution in highly segmented and position sensitive detectors were developed. The signal-to-noise ratio was improved through averaging of the core and the segment signals, which led to an improvement of the energy resolution of 21% for γ-energies of 60 keV to a FWHM of 870 eV. In combination with crosstalk correction, a clearly improved energy resolution was

Study of vacancy decays in the L-shell photoionization of barium in the excitation energy range of 5.6-30 keV: from L{sub 2} edge to energy high above the thresholds of double L-vacancy production

Energy Technology Data Exchange (ETDEWEB)

Zou, Y [Key Laboratory of Applied Ion Beam Physics (Chinese Educational Ministry), Fudan University, Shanghai 200433 (China); Oura, M [RIKEN Spring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Hutton, R [Lund Observatory, SE-221 00 Lund (Sweden); Yamaoka, H [RIKEN Spring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148 (Japan); Takeshima, N [Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585 (Japan); Takahiro, K [Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585 (Japan); Kawatsura, K [Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585 (Japan); Mukoyama, T [Kansai Gaidai University, 16-1 Nakamiyahigashino-cho, Hirakata, Osaka 573-1001 (Japan)

2006-11-28

Photoinduced Ba L x-rays were measured, in the excitation energy range of 5.6-30 keV, by using high-brilliance undulator radiation. The obtained intensity ratios, the excitation-energy independent L{beta}{sub 4}/L{beta}{sub 3}, L{eta}/L{beta}{sub 1}, L{iota}/L{alpha}{sub 1,2}, L{beta}{sub 6}/L{alpha}{sub 1,2} and L{beta}{sub 2,15}/L{alpha}{sub 1,2} as well as the excitation-energy dependent L{beta}{sub 1}/L{alpha}{sub 1,2}, L{beta}{sub 3}/L{alpha}{sub 1,2} and L{beta}{sub 3}/L{beta}{sub 1}, were compared with theoretical calculations, in which the calculations were performed by applying various subsets of the L subshell fluorescence yields and Coster-Kronig yields. Deviations of the theoretical calculations from the experimental results call on improvements in theory for the emission rates. We have also surveyed the L{alpha}{sub 1,2} related x-ray hypersatellite lines in the photoinduced Ba L x-ray spectrum.

Short-range order in the quantum XXZ honeycomb lattice material BaCo2(PO4)2

Science.gov (United States)

Nair, Harikrishnan S.; Brown, J. M.; Coldren, E.; Hester, G.; Gelfand, M. P.; Podlesnyak, A.; Huang, Q.; Ross, K. A.

2018-04-01

We present observations of highly frustrated quasi-two-dimensional (2D) magnetic correlations in the honeycomb lattice layers of the Seff =1 /2 compound γ -BaCo2(PO4)2 (γ -BCPO). Specific heat shows a broad peak comprised of two weak kink features at TN 1˜6 K and TN 2˜3.5 K, the relative weights of which can be modified by sample annealing. Neutron powder diffraction measurements reveal short range quasi-2D order that is established below TN 1 and TN 2, at which two separate, incompatible, short range magnetic orders onset: commensurate antiferromagnetic correlations with correlation length ξc=60 ±2 Å (TN 1) and in quasi-2D helical domains with ξh=350 ±11 Å (TN 2). The ac magnetic susceptibility response lacks frequency dependence, ruling out spin freezing. Inelastic neutron scattering data on γ -BCPO is compared with linear spin wave theory, and two separate parameter regions of the XXZ J1-J2-J3 model with ferromagnetic nearest-neighbor exchange J1 are favored, both near regions of high classical degeneracy. High energy coherent excitations (˜10 meV) persist up to at least 40 K, suggesting strong in-plane correlations persist above TN. These data show that γ -BCPO is a rare highly frustrated, quasi-2D Seff =1 /2 honeycomb lattice material which resists long range magnetic order and spin freezing.

Renewable energy and CO_2 abatement in Italy

International Nuclear Information System (INIS)

Marcantonini, Claudio; Valero, Vanessa

2017-01-01

In order to combat global warming, Italy has committed to reduce its CO_2 emissions. To this end, it has significantly encouraged renewable energy development through a variety of support schemes, ranging from green certificates to feed-in and premium tariffs. As a result, the production of electricity from renewable energy sources, in particular from solar and wind energy, has risen considerably over the past years. In this paper we review the Italian support schemes for wind and solar energy and estimate the cost of abating CO_2 emissions by generating electricity from these two sources of energy for the period 2008–2011. The results show that the average costs for wind were around 165 €/tCO_2. For solar, they were much higher, around 1000 €/tCO_2, as solar energy received much higher remunerations than wind energy. These costs were much higher than in Germany. This was due to the differences between the level of incentives and the different power systems. - Highlights: • We estimate the cost of reducing CO_2 emissions by wind and solar energy in Italy in 2008–2011. • The average costs for wind were around 165 €/tCO_2. • The average costs for solar were much higher, around 1000 €/tCO_2. • Those costs were much higher than in Germany. • This was due to the differences in the levels of incentives and to the different power systems.

Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.

Science.gov (United States)

Burrows, Jeremy N; Cumming, John G; Fillery, Shaun M; Hamlin, Gordon A; Hudson, Julian A; Jackson, Ruth J; McLaughlin, Sharon; Shaw, John S

2005-01-03

Investigation of weak screening hits led to the identification of N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides and N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-N'-benzylureas as potent, selective ligands for the human CCR5 chemokine receptor.

Circulating levels of miR-133a predict the regression potential of left ventricular hypertrophy after valve replacement surgery in patients with aortic stenosis.

Science.gov (United States)

García, Raquel; Villar, Ana V; Cobo, Manuel; Llano, Miguel; Martín-Durán, Rafael; Hurlé, María A; Nistal, J Francisco

2013-08-15

Myocardial microRNA-133a (miR-133a) is directly related to reverse remodeling after pressure overload release in aortic stenosis patients. Herein, we assessed the significance of plasma miR-133a as an accessible biomarker with prognostic value in predicting the reversibility potential of LV hypertrophy after aortic valve replacement (AVR) in these patients. The expressions of miR-133a and its targets were measured in LV biopsies from 74 aortic stenosis patients. Circulating miR-133a was measured in peripheral and coronary sinus blood. LV mass reduction was determined echocardiographically. Myocardial and plasma levels of miR-133a correlated directly (r=0.46, Pregression analysis identified plasma miR-133a as a positive predictor of the hypertrophy reversibility after surgery. The discrimination of the model yielded an area under the receiver operator characteristic curve of 0.89 (Pregression analysis revealed plasma miR-133a and its myocardial target Wolf-Hirschhorn syndrome candidate 2/Negative elongation factor A as opposite predictors of the LV mass loss (g) after AVR. Preoperative plasma levels of miR-133a reflect their myocardial expression and predict the regression potential of LV hypertrophy after AVR. The value of this bedside information for the surgical timing, particularly in asymptomatic aortic stenosis patients, deserves confirmation in further clinical studies.

Photospallation reactions of 133Cs and 139La by 100 MeV- and 200 MeV bremsstrahlungs

International Nuclear Information System (INIS)

Sakamoto, K.; Toramoto, H.; Hamajima, Y.; Okada, K.; Dohniwa, M.

1984-01-01

Spallation yields relative to the 196 Au yield from 197 Au(γ,n) of 26 to 46 nuclides of Sb, Te, I, Xe, Cs and/or Ba and La from 133 Cs and 139 La targets irradiated with bremsstrahlungs of end energies of 100 MeV and 200 MeV were radiochemically determined. The isomeric yield ratios for 132 La and 131 Ba from the ( 139 La + 100 MeV-γ), 132 La, 131 Ba, 121 Te and 119 Te from the ( 139 La + 200 MeV-γ, and 120 I, 121 Te and 119 Te from the ( 133 Cs +- 200 MeV-γ) were also determined. The isotopic yields from the (γ,yn) reactions decrease exponentially with increase of y up to 5, and show no dependence on energy and targets studied, indicating that the reactions of a few neutron emissions occur at energies lower than 100 MeV. When the product yields from the (γ,xpyn) reactions were plotted against (x + y) for each x (isotopic distribution), a regular variation of the Gaussian distributions, typical of nuclear spallation, was observed. Isobaric mass distributions and charge dispersions were deduced to extract characteristic features of these reactions. The isobaric distributions due only to photons of 100 MeV to 200 MeV, which were obtained by subtracting the 100 MeV-yields from the 200 MeV-yields, are very close to a symmetric one peaking at about 8 amu from the target masses. Nuclear charges are also dispersed symmetrically, with most probable N/Zsub(p) of about 1.3 replaced by about 1 amu to the neutron-deficient side from the beta stability valley in all the cases studied. Parameters included in Rudstam's semi-empirical formula were examined by comparing with the observed yield curves. The P values of 0.45 and 0.65, chosen for a better fit to the 200 MeV data on 133 Cs and 139 La, respectively, were larger than the predictions reported in the literature. The magic number effects of 139 La may explain the target-differences in mass distributions. (orig.)

VUV photoionization of acetamide studied by electron/ion coincidence spectroscopy in the 8–24 eV photon energy range

International Nuclear Information System (INIS)

Schwell, Martin; Bénilan, Yves; Fray, Nicolas; Gazeau, Marie-Claire; Es-Sebbar, Et.; Garcia, Gustavo A.; Nahon, Laurent; Champion, Norbert; Leach, Sydney

2012-01-01

Highlights: ► We study the VUV photoionization of acetamide in the 8–24 eV photon energy range. ► Electron/ion coincidence measurements are performed using synchrotron radiation. ► The adiabatic ionization energy of acetamide is determined by TPEPICO measurements. ► VUV induced fragmentation pathways of acetamide are assigned and discussed. - Abstract: A VUV photoionization study of acetamide was carried out over the 8–24 eV photon energy range using synchrotron radiation and photoelectron/photoion coincidence (PEPICO) spectroscopy. Threshold photoelectron photoion coincidence (TPEPICO) measurements were also made. Photoion yield curves and branching ratios were measured for the parent ion and six fragment ions. The adiabatic ionization energy of acetamide was determined as I.E. (1 2 A′) = (9.71 ± 0.02) eV, in agreement with an earlier reported photoionization mass spectrometry (PIMS) value. The adiabatic energy of the first excited state of the ion, 1 2 A″, was determined to be ≈10.1 eV. Assignments of the fragment ions and the pathways of their formation by dissociative photoionization were made. The neutral species lost in the principal dissociative photoionization processes are CH 3 , NH 2 , NH 3 , CO, HCCO and NH 2 CO. Heats of formation are derived for all ions detected and are compared with literature values. Some astrophysical implications of these results are discussed.

2 mm range ESR of the transmutation-produced phosphorus impurity in 6HSiC

International Nuclear Information System (INIS)

Kalabukhova, E.N.; Lukin, S.N.; Mokhov, E.N.

1993-01-01

Phosphorus impurity is introduced into 6HSiC monocrystals via neutron transmutation doping. Parameters of ESR two spectra referred to ESR spectra of separated phosphorus atoms in the lattice cubic and hexagonal position are detected and determined in the specimens at T=4.2 K. variation dynamics of ESR spectra of phosphorus and nitrogen within 4.2-73 K temperature range is studied. Ionization energies of phosphorus atoms are determined to be less, than those of nitrogen atoms, and ionization energy of phosphorus atoms in hexagonal position is higher, than that of phosphorus atoms in cubic position

Review of xenon-133 production and related problems

International Nuclear Information System (INIS)

Barrachina, M.; Ropero, M.

1980-01-01

A literature survey is given on the production methods of fission xenon-133 and related problems, such as purification, metrological and dosimetric aspects, preparation of isotopic solutions, recycling, etc. 127 references are included. (Author) 127 refs

CO-ANALYSIS OF SOLAR MICROWAVE AND HARD X-RAY SPECTRAL EVOLUTIONS. I. IN TWO FREQUENCY OR ENERGY RANGES

International Nuclear Information System (INIS)

Song Qiwu; Huang Guangli; Nakajima, Hiroshi

2011-01-01

Solar microwave and hard X-ray spectral evolutions are co-analyzed in the 2000 June 10 and 2002 April 10 flares, and are simultaneously observed by the Owens-Valley Solar Array in the microwave band and by Yohkoh/Hard X-ray Telescope or RHESSI in the hard X-ray band, with multiple subpeaks in their light curves. The microwave and hard X-ray spectra are fitted by a power law in two frequency ranges of the optical thin part and two photon energy ranges, respectively. Similar to an earlier event in Shao and Huang, the well-known soft-hard-soft pattern of the lower energy range changed to the hard-soft-hard (HSH) pattern of the higher energy range during the spectral evolution of each subpeak in both hard X-ray flares. This energy dependence is actually supported by a positive correlation between the overall light curves and spectral evolution in the lower energy range, while it becomes an anti-correlation in the higher energy range. Regarding microwave data, the HSH pattern appears in the spectral evolution of each subpeak in the lower frequency range, which is somewhat similar to Huang and Nakajima. However, it returns back to the well-known pattern of soft-hard-harder for the overall spectral evolution in the higher frequency range of both events. This frequency dependence is confirmed by an anti-correlation between the overall light curves and spectral evolution in the lower frequency range, but it becomes a positive correlation in the higher frequency range. The possible mechanisms are discussed, respectively, for reasons why hard X-ray and microwave spectral evolutions have different patterns in different energy and frequency intervals.

Optical frequency measurements of 6s 2S1/2-6p 2P3/2 transition in a 133Cs atomic beam using a femtosecond laser frequency comb

International Nuclear Information System (INIS)

Gerginov, V.; Tanner, C.E.; Diddams, S.; Bartels, A.; Hollberg, L.

2004-01-01

Optical frequencies of the hyperfine components of the D 2 line in 133 Cs are determined using high-resolution spectroscopy and a femtosecond laser frequency comb. A narrow-linewidth probe laser excites the 6s 2 S 1/2 (F=3,4)→6p 2 P 3/2 (F=2,3,4,5) transition in a highly collimated atomic beam. Fluorescence spectra are taken by scanning the laser frequency over the excited-state hyperfine structure. The laser optical frequency is referenced to a Cs fountain clock via a reference laser and a femtosecond laser frequency comb. A retroreflected laser beam is used to estimate and minimize the Doppler shift due to misalignment between the probe laser and the atomic beam. We achieve an angular resolution on the order of 5x10 -6 rad. The final uncertainties (∼±5 kHz) in the frequencies of the optical transitions are a factor of 20 better than previous results [T. Udem et al., Phys. Rev. A 62, 031801 (2000).]. We find the centroid of the 6s 2 S 1/2 →6p 2 P 3/2 transition to be f D2 =351 725 718.4744(51) MHz

Quantum computing applied to calculations of molecular energies: CH2 benchmark

Czech Academy of Sciences Publication Activity Database

Veis, L.; Pittner, Jiří

2010-01-01

Roč. 133, č. 19 (2010), s. 194106 ISSN 0021-9606 R&D Projects: GA ČR GA203/08/0626 Institutional research plan: CEZ:AV0Z40400503 Keywords : computation * algorithm * systems Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 2.920, year: 2010

Energy booklet. Energy saving tips for more pocket money and environment. Booklet 2; EnergieSparFibel. EnergieSparTipps fuer mehr Taschengeld und Umwelt. Heft 2

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-07-01

The effective environmental protection begins when saving. Energy which is not used at all also cannot burden the environment. Pleasant side effect: also the purse is treated gently. One of the most important measures for the reduction of energy consumption is the correct thermal insulation of a building so that heating energy cannot escape unused in the free. Thus, between 50 and 75 per cent of energy can be saved. Investments within this range usually are profitable already after a short time. The utilization of damming materials from regenerative raw materials enables application of financial incentives. In addition, within other ranges of the house modernizations and a change of the behaviour of utilization help to save energy. The contribution under consideration gives advices in order to improve dwellings energy-technically. The environment and the purse will thank it.

Mutations in the Ras-Raf Axis Underlie the Prognostic Value of CD133 in Colorectal Cancer

NARCIS (Netherlands)

Kemper, Kristel; Versloot, Miranda; Cameron, Katherine; Colak, Selçuk; de Sousa E Melo, Felipe; de Jong, Joan H.; Bleackley, Joanne; Vermeulen, Louis; Versteeg, Rogier; Koster, Jan; Medema, Jan Paul

2012-01-01

Purpose: High expression of cancer stem cell (CSC) marker CD133 has been used as a predictor for prognosis in colorectal cancer (CRC), suggesting that enumeration of CSCs, using CD133, is predictive for disease progression. However, we showed recently that both CD133 mRNA and protein are not

27 CFR 31.133 - Change in management.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Change in management. 31..., DEPARTMENT OF THE TREASURY LIQUORS ALCOHOL BEVERAGE DEALERS Changes in Registration Information Other Changes § 31.133 Change in management. A change in management that involves no change in ownership of the...

Studying the Range of Incident Alpha Particles on Cu , Ge , Ag , Cd , Te and Au, With Energy (4-15 MeV)

International Nuclear Information System (INIS)

Kadhim, R.O.; Jasim, W.N.

2015-01-01

In this paper theoretical calculation of the range for alpha particles with the energy range (4 – 15)MeV when passing in some metallic media (Cu , Ge , Ag , Cd , Te and Au).Semi empirical formula was used in addition to (SRIM-2012) program. The Semi empirical equation was programmed to calculate the range using Matlab Language.The results of the range in these media were compared with the results obtained from SRIM-2012 and )(2011)Andnet) results.There was good agreement among the semi empirical equation result , SRIM- 2012 results and with )(2011)Andnet) results in the low energy.The results showed exponential relation between the range of alpha particles in these media and the velocity of the particles.By recourse with SRIM- 2012 results and application them in Matlab program and by using Curve Fitting Tool we extraction equation with its constants to calculate the range of alpha particles in any element of these six elements with the energy range (4 – 15)MeV.The maximum deviation between the results from the semi empirical calculation and SRIM-2012 results was calculated the statistical test ( kstest2) in Matlab program

Commercial cyclotrons. Part I: Commercial cyclotrons in the energy range 10 30 MeV for isotope production

Science.gov (United States)

Papash, A. I.; Alenitsky, Yu. G.

2008-07-01

A survey of commercial cyclotrons for production of medical and industrial isotopes is presented. Compact isochronous cyclotrons which accelerate negative hydrogen ions in the energy range 10 30 MeV have been widely used over the last 25 years for production of medical isotopes and other applications. Different cyclotron models for the energy range 10 12 MeV with moderate beam intensity are used for production of 11C, 13N, 15O, and 18F isotopes widely applied in positron emission tomography. Commercial cyclotrons with high beam intensity are available on the market for production of most medical and industrial isotopes. In this work, the physical and technical parameters of different models are compared. Possibilities of improving performance and increasing intensity of H- beams up to 2 3 mA are discussed.

Energy of N two-dimensional bosons with zero-range interactions

Science.gov (United States)

Bazak, B.; Petrov, D. S.

2018-02-01

We derive an integral equation describing N two-dimensional bosons with zero-range interactions and solve it for the ground state energy B N by applying a stochastic diffusion Monte Carlo scheme for up to 26 particles. We confirm and go beyond the scaling B N ∝ 8.567 N predicted by Hammer and Son (2004 Phys. Rev. Lett. 93 250408) in the large-N limit.

miR-133b down-regulates ABCC1 and enhances the sensitivity of CRC to anti-tumor drugs.

Science.gov (United States)

Chen, Miao; Li, Daojiang; Gong, Ni; Wu, Hao; Su, Chen; Xie, Canbin; Xiang, Hong; Lin, Changwei; Li, Xiaorong

2017-08-08

Multidrug resistance (MDR) is the main cause of failed chemotherapy treatments. Therefore, preventing MDR is pivotal in treating colorectal cancer (CRC). In a previous study miR-133b was shown to be a tumor suppressor. Additionally, in CRC cells transfected with miR-133b, ATP-binding cassette (ABC) subfamily C member 1(ABCC1) was shown to be significantly down regulated. Whether miR-133b also enhances the chemosensitivity of drugs used to treat CRC by targeting ABCC1 is still unclear. Here, we utilized flow cytometry and high-performance liquid chromatography (HPLC) analysis to identify the ability of miR-133b to reserve MDR in CRC. We then used a dual-luciferase reporter assay to validate that miR-133b targets ABCC1. Further in vivo experiments were designed to validate the method in which miR-133b reversed MDR in CRC cells. The results demonstrated that the level of miR-133b was down-regulated and the expression of ABCC1 was up-regulated in drug-resistant CRC cells compared to non-drug-resistant CRC cells. The restoration of miR-133b expression in CRC drug-resistant cells in vitro resulted in reduced IC50s to chemotherapeutic drugs, significantly induced G1 accumulation, inhibited growth and promoted necrosis in combination with either 5-fluorouracil (5-FU) or vincristine (VCR), and decreased the expression of ABCC1. The dual-luciferase assay demonstrated that miR-133b directly targets ABCC1. The combination of agomiRNA-133b with chemotherapeutic drugs in vivo inhibited tumor growth induced by CRC drug-resistant cells. A xenograft from the in vivo model resulted in up-regulated levels of miR-133b and down-regulated levels of ABCC1. Therefore, miR-133b enhances the chemosensitivity of CRC cells to anti-tumor drugs by directly down-regulating ABCC1. This discovery provides a therapeutic strategy in which miR-133b is used as a potential sensitizer for drug-resistant CRC.

Determination of muscle microcirculation of the limbs of healthy persons and patients with scleroderma by means of 133Xe clearance. 2

International Nuclear Information System (INIS)

Poenitzsch, I.; Wiemers, U.; Haustein, U.F.; Schneider, G.

1984-01-01

By means of 133 Xe muscle clearance the blood flow of the musculus tibialis anterior and the musculus opponens pollicis was determined during nonischemic work and after 3 minutes ischemia in patients with progressive scleroderma and additionally of the ischemic musculus opponens pollicis following contrast baths. In relation to 53 patients with normal vessels the reactive hyperemia of the musculus tibialis anterior after ischemia and of the musculus opponens pollicis after heat, cold as well as arterial flow decreasing was significantly decreased in patients with scleroderma and was as a disturbance of the microcirculation realized. For scientific problems in progressive scleroderma the 133 Xe muscle clearance is suitable as to the musculus opponens pollicis. (author)

21 CFR 133.174 - Pasteurized process cheese food with fruits, vegetables, or meats.

Science.gov (United States)

2010-04-01

..., vegetables, or meats. 133.174 Section 133.174 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... with fruits, vegetables, or meats. (a) Pasteurized process cheese food with fruits, vegetables, or... fruits, vegetables, or meats is “Pasteurized process cheese food with ___”, the blank being filled in...

46 CFR 133.40 - Evaluation, testing and approval of lifesaving appliances and arrangements.

Science.gov (United States)

2010-10-01

... appliances and arrangements. 133.40 Section 133.40 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... lifesaving appliances and arrangements. (a) Each item of lifesaving equipment required by this part to be... OCMI for use on the OSV. (c) The Commandant (CG-521) may accept a novel lifesaving appliance or...

Characterization and optimization of laser-driven electron and photon sources in keV and MeV energy ranges

International Nuclear Information System (INIS)

Bonnet, Thomas

2013-01-01

This work takes place in the framework of the characterization and the optimization of laser-driven electron and photon sources. With the goal of using these sources for nuclear physics experiments, we focused on 2 energy ranges: one around a few MeV and the other around a few tens of keV. The first part of this work is thus dedicated to the study of detectors routinely used for the characterization of laser-driven particle sources: Imaging Plates. A model has been developed and is fitted to experimental data. Response functions to electrons, photons, protons and alpha particles are established for SR, MS and TR Fuji Imaging Plates for energies ranging from a few keV to several MeV. The second part of this work present a study of ultrashort and intense electron and photon sources produced in the interaction of a laser with a solid or liquid target. An experiment was conducted at the ELFIE facility at LULI where beams of electrons and photons were accelerated up to several MeV. Energy and angular distributions of the electron and photons beams were characterized. The sources were optimized by varying the spatial extension of the plasma at both the front and the back end of the initial target position. In the optimal configuration of the laser-plasma coupling, more than 1011 electrons were accelerated. In the case of liquid target, a photon source was produced at a high repetition rate on an energy range of tens of keV by the interaction of the AURORE Laser at CELIA (10 16 W.cm -2 ) and a melted gallium target. It was shown that both the mean energy and the photon number can be increased by creating gallium jets at the surface of the liquid target with a pre-pulse. A physical interpretation supported by numerical simulations is proposed. (author)

27 CFR 28.133 - Disposition of forms.

Science.gov (United States)

2010-04-01

..., or Transportation to a Manufacturing Bonded Warehouse Return of Wines to Bonded Wine Cellar § 28.133 Disposition of forms. On receipt of the wines at the bonded wine cellar, the proprietor shall endorse, on each..., DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Withdrawal of Wine Without Payment of Tax for...

Alterations of regional pulmonary function in patients with mitral stenosis studied with xenon-133 following surgical treatment

International Nuclear Information System (INIS)

Kurata, Naohiko

1983-01-01

The purpose of this study is to investigate the regional pulmonary function in mitral stenosis using Xenon-133 before and after surgical treatment. Twenty-seven patients with mitral stenosis have been studied. There were four types of distribution of pulmonary perfusion. According to the increase of pulmonary capillary wedge pressure, the distribution of pulmonary perfusion showed a vertical distribution different from that of normal man, as well known according to the many past reports. But Type IV(PCWP > 30mmHg) showed the distribution uniform throughout the lung. The patients with Type IV had severe pulmonary vascular resistance and abnormal distribution of ventilation. They showed decreased %VC, SaO 2 and increased FRV in the tests of total lung functions. Postoperatively, the distribution of pulmonary perfusion in Type II and Type III returned to normal after 6 - 12 months of surgical treatment, but in the Type IV never returned to normal even after 12 months of surgical treatment. The hemodynamic data in the Type IV after 3 - 6 months of surgical treatment showed the moderate pulmonary hypertension and pulmonary vascular resistance. In total lung function tests, %VC, SaO 2 and FRV were recognized the improvement after surgical treatment, but they retained under normal range even after 12 months of sutgical treatment. The abnormal distribution of ventilation improved to normal distribution after 12 months of surgical treatment. The regional pulmonary function test using Xenon-133 is very beneficial to estimate the severity of mitral stenosis and to expect the effects of surgical treatment on the pulmonary circulation and ventilation. (J.P.N.)

Deuteron stripping on beryllium target in the 100-2300 MeV energy range

International Nuclear Information System (INIS)

Lecolley, J.F.; Varignon, C.; Durand, D.; Le Brun, C.; Lecolley, F.R.; Lefebvres, F.; Louvel, M.; Thun, J.; Borne, F.; Martinez, E.; Menard, S.; Pras, P.; Boudard, A.; Duchazeaubeneix, J.C.; Durand, J.M.; Frehaut, J.; Hanappe, F.; Ledoux, X.; Legrain, R.; Leray, S.; Milleret, G.; Patin, Y.; Stuttge, L.; Terrien, Y.

1999-01-01

Cross sections for stripping and dissociation of deuterons interacting with Be targets in the 100-2300 MeV energy range have been measured. Comparisons with model calculations suggest a dominant contribution of the stripping process. It is also shown that the deuteron break-up cross section exhibits the same energy dependence as the nucleon-nucleon cross section. (orig.)