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Sample records for energy act atg

  1. Atomic Energy Act (AtG) and subordinate legislation. Collections. 35. ed.

    International Nuclear Information System (INIS)

    Ziegler, Eberhard

    2018-01-01

    The Atomic Energy Act (AtG) and subordinate legislation covers the following issues: The German constitution, the atomic energy act, subordinate process regulations, radiation protection regulation, X-ray regulation, financial security regulation, cost regulations, safety delegate and reporting regulations, law on the installation of a Federal Office for nuclear disposal security, site selection law, final repository advance financing, radioactive waste transport regulation, disposal fund law, regulation on the payment receipt according to the disposal fund law, transitional disposal law, transparency law, run-off liability law, law on the installation of the Federal office for radiation protection, radiation protection law, food irradiation law, regulation on drug treatment with radioactivity or ionizing radiation, Paris agreement on nuclear liabilities and additional agreement, joint protocol on the application of the Vienna and Paris agreements, environmental compatibility assessment law, criminal code (partial), state competence regulations on the execution of regulations according the atomic energy act.

  2. Atomic Energy Act (AtG) and subordinate legislation. Collections. 35. ed.; Atomgesetz mit Verordnungen. Textsammlung

    Energy Technology Data Exchange (ETDEWEB)

    Ziegler, Eberhard (ed.)

    2018-03-01

    The Atomic Energy Act (AtG) and subordinate legislation covers the following issues: The German constitution, the atomic energy act, subordinate process regulations, radiation protection regulation, X-ray regulation, financial security regulation, cost regulations, safety delegate and reporting regulations, law on the installation of a Federal Office for nuclear disposal security, site selection law, final repository advance financing, radioactive waste transport regulation, disposal fund law, regulation on the payment receipt according to the disposal fund law, transitional disposal law, transparency law, run-off liability law, law on the installation of the Federal office for radiation protection, radiation protection law, food irradiation law, regulation on drug treatment with radioactivity or ionizing radiation, Paris agreement on nuclear liabilities and additional agreement, joint protocol on the application of the Vienna and Paris agreements, environmental compatibility assessment law, criminal code (partial), state competence regulations on the execution of regulations according the atomic energy act.

  3. Atomic Energy Act (AtG) and subordinate legislation. 19. ed.

    International Nuclear Information System (INIS)

    Ziegler, E.

    1995-01-01

    This 19th edition covers the amendments added since the 17th edition ( March 1994 ) referring to the following: (1) AtG sections 7 and 9a (Artikelgesetz, as of 19.7. 1994, published in BGBl I, p. 1618 ff); (2) incorporation of the legal requirements governing the environmental impact statement (EIS) in compliance with the EIS Act (UVPG) into the Nuclear Installations Ordinance (BGBl I, p. 181 ff); (3) amendment of the Radiation Protection Ordinance (StrlSchV) in sections 6, 22, 31, 42, 87, sub-sec. 2, due to the new act on medical products, in section 41 due to the amended act on health care facilities and services, and in section 87, sub-sec. 1 due to section 7 of the 31st penal reform law - 2nd law to combat environmental crime; (4) amendment of the Preventive Radiation Protection Act in section 11, extension of competence of the BfS (Federal Rad. Prot. Office); (5) amendment of the Penal Code, environmental crime committed by release of ionizing radiation, or faulty construction of a nuclear installation; (6) update of provisions concerning competences of the federal states in implementation of nuclear laws. In the 19th edition of the commentary, the numbering of the various acts and ordinances, and the relevant page numbering have been completely revised. (HP) [de

  4. Atomic Energy Act (AtG) and subordinate legislation. Collections. 33. ed.

    International Nuclear Information System (INIS)

    Ziegler, Eberhard

    2014-01-01

    The 33rd edition of the present statute book contains the Site Selection Law (StandAG) of 25 July 2013, which specifies the procedure for selecting sites for final disposal of high-level radioactive wastes, and the Law on the Establishment of a Federal Office for Disposal of Radioactive Wastes, promulgated as Art. 3 of the Site Selection Law. Some regulations of the StandAG already took effect on 27 July 2013, while others are to be enacted on 1 January 2014 along with amendments to the Atomic Energy Law, the Schedule of Costs to the Atomic Energy Law and the Law on Environmental Impact Assessments that result from the StandAG. The new edition also includes legislative amendments that were passed after the publication of the previous edition, namely those to the Food Irradiation Ordinance, the Law on the Establishment of the Federal Radiation Protection Office and to relevant regulations of the Criminal Code.

  5. The jurisdiction of administrative courts in disputes about the payment of costs incurred for investigating or supervisory tasks in compliance with section 21 AtG (Atomic Energy Act). Hess. VGH, decision of August 2, 1993 - 14 A 995/92

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    Disputes about payment of costs incurred by investigating or supervisory tasks in compliance with section 21 AtG (Atomic Energy Act) are to be settled by a the first instance, the administrative courts. (Judgment of Higher Adm. Court of Hesse, as of August 2, 1993 - 14 A 995/92). (orig./HSCH) [de

  6. The liability according to paragraph 26 of the German Atomic Energy Act. A wallflower?; Die Haftung nach paragraph 26 AtG. Ein Mauerbluemchen?

    Energy Technology Data Exchange (ETDEWEB)

    Raetzke, Christian [CONLAR Consulting on Nuclear Law and Regulation, Leipzig (Germany)

    2018-02-15

    According to German law, liability for damage caused by radioactivity can arise from several regulations. In most cases, liability under the Paris Convention on Third Party Liability in the Field of Nuclear Energy, which applies in the field of nuclear power, is at the forefront of discussion. According to paragraph 26 of the German Atomic Energy Act, liability is somewhat in the shadow of the Paris Convention. It applies to the handling of radioactivity in medicine, research and industry (e.g. for test emitters) as well as activities involving natural and depleted uranium and nuclear fusion. The article outlines the basic elements of liability under Section 26 of the German Atomic Energy Act, which may become increasingly important in future due to recent developments such as the phasing out of nuclear power in Germany.

  7. Evaluation of research projects and studies on nuclear safety in the context of implementation of the German Atomic Energy Act (AtG). Vol. 9

    International Nuclear Information System (INIS)

    Casper, H.

    2000-01-01

    The content of this report is a collection of research projects and investigations in the field of nuclear safety evaluated in 1999 and 2000 with regard to the application of the Atomic Energy Act (Atomgesetz). In addition the report gives an overview on objectives and procedures used for the evaluation. The purpose of this project, being executed for the Federal Ministry for Environment, Nature Conservation and Nuclear Safety (BMU) of the Federal Republic of Germany is to inform all parties involved in the licensing procedure as well as the consulting councils on the latest nuclear safety research results and the status of their verification in a precise short manner. In addition experts' opinions are given with regard to the relevance of these research results to nuclear rules and guidelines as well as to the execution of the Atomic Energy Act. The information consists of precise and short evaluations of final research reports or technical reports. These evaluations are prepared by specialists who are acquainted with the technical aspects of the licensing procedure of nuclear plants in the Federal Republic of Germany. This volume is the ninth report of this series. (orig.) [de

  8. The valuation key day in legal expropriation according to the Atomic Energy Act. On the transferability of the legal compensation fundamentals of the so called progression legislation on the 13th AtG amendment

    International Nuclear Information System (INIS)

    Cornils, Matthias

    2015-01-01

    Under the - constitutionally based - regime ruling compensation for expropriated property notably the valuation key day is of crucial importance for the level of compensation. The study examines the therefor acknowledged principles and criteria, their constitutional foundation, their applicability on expropriation measures directly performed by an Act of Parliament, finally their transferability to the 13th amendment to the Atomic Energy Act.

  9. Arabidopsis ATG4 cysteine proteases specificity toward ATG8 substrates

    Science.gov (United States)

    Park, Eunsook; Woo, Jongchan; Dinesh-Kumar, SP

    2014-01-01

    Macroautophagy (hereafter autophagy) is a regulated intracellular process during which cytoplasmic cargo engulfed by double-membrane autophagosomes is delivered to the vacuole or lysosome for degradation and recycling. Atg8 that is conjugated to phosphatidylethanolamine (PE) during autophagy plays an important role not only in autophagosome biogenesis but also in cargo recruitment. Conjugation of PE to Atg8 requires processing of the C-terminal conserved glycine residue in Atg8 by the Atg4 cysteine protease. The Arabidopsis plant genome contains 9 Atg8 (AtATG8a to AtATG8i) and 2 Atg4 (AtATG4a and AtATG4b) family members. To understand AtATG4’s specificity toward different AtATG8 substrates, we generated a unique synthetic substrate C-AtATG8-ShR (citrine-AtATG8-Renilla luciferase SuperhRLUC). In vitro analyses indicated that AtATG4a is catalytically more active and has broad AtATG8 substrate specificity compared with AtATG4b. Arabidopsis transgenic plants expressing the synthetic substrate C-AtAtg8a-ShR is efficiently processed by endogenous AtATG4s and targeted to the vacuole during nitrogen starvation. These results indicate that the synthetic substrate mimics endogenous AtATG8, and its processing can be monitored in vivo by a bioluminescence resonance energy transfer (BRET) assay. The synthetic Atg8 substrates provide an easy and versatile method to study plant autophagy during different biological processes. PMID:24658121

  10. From pricing regulations of the feed-in scheme (EEG) through to financial security under the Atomic Energy Act (AtG): the German legal system for the energy sector in the context of EC legislation on state aid

    International Nuclear Information System (INIS)

    Kuehling, J.

    2001-01-01

    This contribution is a comprehensive analysis of EC law on state aid and resulting possible impacts on the German legal system for the energy sector. The analysis reveals that, depending on the legal interpretation of Art. 87 of the EC Treaty, further non-compliance issues such as that currently under debate in connection with German legislation supporting market penetration of electricity from renewable energy sources, may arise in the future. Further examples referred to are the German system of liability reserves for the decommissioning of nuclear power plants, and the system of third party liability for nuclear power plant operators. The author addresses various problem areas and uses characteristic examples in explaining conceivable matters of conflict. (orig./CB) [de

  11. Differential processing of Arabidopsis ubiquitin-like Atg8 autophagy proteins by Atg4 cysteine proteases

    Science.gov (United States)

    Woo, Jongchan; Park, Eunsook; Dinesh-Kumar, S. P.

    2014-01-01

    Autophagy is a highly conserved biological process during which double membrane bound autophagosomes carry intracellular cargo material to the vacuole or lysosome for degradation and/or recycling. Autophagosome biogenesis requires Autophagy 4 (Atg4) cysteine protease-mediated processing of ubiquitin-like Atg8 proteins. Unlike single Atg4 and Atg8 genes in yeast, the Arabidopsis genome contains two Atg4 (AtAtg4a and AtAtg4b) and nine Atg8 (AtAtg8a–AtAtg8i) genes. However, we know very little about specificity of different AtAtg4s for processing of different AtAtg8s. Here, we describe a unique bioluminescence resonance energy transfer-based AtAtg8 synthetic substrate to assess AtAtg4 activity in vitro and in vivo. In addition, we developed a unique native gel assay of superhRLUC catalytic activity assay to monitor cleavage of AtAtg8s in vitro. Our results indicate that AtAtg4a is the predominant protease and that it processes AtAtg8a, AtAtg8c, AtAtg8d, and AtAtg8i better than AtAtg4b in vitro. In addition, kinetic analyses indicate that although both AtAtg4s have similar substrate affinity, AtAtg4a is more active than AtAtg4b in vitro. Activity of AtAtg4s is reversibly inhibited in vitro by reactive oxygen species such as H2O2. Our in vivo bioluminescence resonance energy transfer analyses in Arabidopsis transgenic plants indicate that the AtAtg8 synthetic substrate is efficiently processed and this is AtAtg4 dependent. These results indicate that the synthetic AtAtg8 substrate is used efficiently in the biogenesis of autophagosomes in vivo. Transgenic Arabidopsis plants expressing the AtAtg8 synthetic substrate will be a valuable tool to dissect autophagy processes and the role of autophagy during different biological processes in plants. PMID:24379391

  12. ''Further precaution'' in Atomic Energy Law? On unconstitutionality of paragraph 7d AtG

    International Nuclear Information System (INIS)

    Rossnagel, Alexander; Hentschel, Anja

    2011-01-01

    On 1st January 2011 the new paragraph 7d of the Atomic Energy Act became operative with the 12th Modification Law according to the Atomic Energy Law. This new paragraph introduces a new category of the nuclear-legal prevention of damage. The contribution under consideration examines how this new regulation for further precautionary actions against risks is to be understood within the existing regulations for permission and retrofitting of nuclear power plants and within the acknowledged dogmatics of the Atomic Energy Act. In addition it is examined whether this understanding of the regulations agrees with the jurisdiction of the constitutional court according to the nuclear legal protection obligations.

  13. Information by the Federal Minister of the Interior concerning Para. 7 of the Atomic Energy Act

    International Nuclear Information System (INIS)

    1980-01-01

    The structural characteristics of Section 7 of the AtG (Atomic Energy Act) have been proved. The changings of the permission assumptions of Section 7 of the Atomic Energy Act by means of a substitution of the applied undefined legal terms cannot be aspired. The jurisdiction of the Federal Constitutional Court has confirmed this interpretation. (orig.) [de

  14. Energy Policy Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Energy Policy Act (EPA) addresses energy production in the United States, including: (1) energy efficiency; (2) renewable energy; (3) oil and gas; (4) coal; (5)...

  15. The valuation key day in legal expropriation according to the Atomic Energy Act. On the transferability of the legal compensation fundamentals of the so called progression legislation on the 13th AtG amendment; Der Bewertungsstichtag bei der atomrechtlichen Legalenteignung. Zur Uebertragbarkeit der entschaedigungsrechtlichen Grundsaetze der sogenannten 'Steigerungsrechtsprechung' auf die 13. AtG-Novelle

    Energy Technology Data Exchange (ETDEWEB)

    Cornils, Matthias

    2015-07-01

    Under the - constitutionally based - regime ruling compensation for expropriated property notably the valuation key day is of crucial importance for the level of compensation. The study examines the therefor acknowledged principles and criteria, their constitutional foundation, their applicability on expropriation measures directly performed by an Act of Parliament, finally their transferability to the 13th amendment to the Atomic Energy Act.

  16. Atomic Energy Act and ordinances. 8. ed.

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    The new issue of the text contains the Atomic Energy Act (AtG) in its new wording of the announcement of 31 Oct 76, the new wording of the ordinances put in effect in 1977: Atomic procedure ordinance (AtVfV), radiation protection ordinance (SSU), and atomic financial security ordinance (AtDeckV); furthermore the x-ray ordinance (RoeV) of 1978 in its wording which has been changed by the radiation protection ordinance. Also printed are the cost ordinance (AtKostV) of 1971, the food irradiation ordinance (LebensmBestrV) in the wording of 1975 and the medicine ordinance (ArzneimV) in the wording of 1971. An addition was made by adding to the liability laws the Paris agreement (PUE) on the liability towards third persons in the field of nuclear energy in the wording of the announcement of 5 Feb 76. (orig./HP) [de

  17. Atomic Energy Control Act

    International Nuclear Information System (INIS)

    1970-01-01

    This act provides for the establishment of the Atomic Energy Control Board. The board is responsible for the control and supervision of the development, application and use of atomic energy. The board is also considered necessary to enable Canada to participate effectively in measures of international control of atomic energy

  18. Atomic Energy Commission Act, 2000 (Act 588)

    International Nuclear Information System (INIS)

    2000-01-01

    Act 588 of the Republic of Ghana entitled, Atomic Energy Commission Act, 2000, amends and consolidates the Atomic Energy Commission Act, 204 of 1963 relating to the establishment of the Atomic Energy Commission. Act 588 makes provision for the Ghana Atomic Energy Commission to establish more institutes for the purpose of research in furtherance of its functions and also promote the commercialization of its research and development results. (E.A.A.)

  19. Atomic Energy Act 1946

    International Nuclear Information System (INIS)

    1946-01-01

    This Act provides for the development of atomic energy in the United Kingdom and for its control. It details the duties and powers of the competent Minister, in particular his powers to obtain information on and to inspect materials, plant and processes, to control production and use of atomic energy and publication of information thereon. Also specified is the power to search for and work minerals and to acquire property. (NEA) [fr

  20. Runtime extension and nuclear safety. On the legal and technological context of the 11th and 12th amendment of the Atomic Energy Act; Laufzeitverlaengerung und nukleare Sicherheit. Zum rechtlichen und technischen Zusammenhang von 11. und 12. AtG Novelle

    Energy Technology Data Exchange (ETDEWEB)

    Renneberg, Wolfgang [Renneberg Consult UG, Alfter (Germany)

    2011-04-15

    The 11th and 12 Amendment of the Atomic Energy Act with which on the one hand the runtime is extended and on the other hand the safety requirements have been renormalized, formally are independent legislative projects. Concerning to the contents, the 12th Amendment appears as an essential element for securing the extension of operation periods. At the same time it constitutes censorship in the safety assessment of nuclear power plants which is equivalent to a modification in the existing security philosophy. The relationships allowing this interpretation go beyond purely legal issues. Therefore the contribution under consideration reports on the legal, safety related and safety political genesis of the actual legal situation following the contributions of Rossnagel/Hentschel and Ziehm.

  1. ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major.

    Directory of Open Access Journals (Sweden)

    Roderick A M Williams

    Full Text Available Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome formation. Nascent autophagosomes were found commonly associated with the mitochondrion. L. major mutants lacking ATG5 (Δatg5 were viable as promastigotes but were unable to form autophagosomes, had morphological abnormalities including a much reduced flagellum, were less able to differentiate and had greatly reduced virulence to macrophages and mice. Analyses of the lipid metabolome of Δatg5 revealed marked elevation of phosphatidylethanolamines (PE in comparison to wild type parasites. The Δatg5 mutants also had increased mitochondrial mass but reduced mitochondrial membrane potential and higher levels of reactive oxygen species. These findings indicate that the lack of ATG5 and autophagy leads to perturbation of the phospholipid balance in the mitochondrion, possibly through ablation of membrane use and conjugation of mitochondrial PE to ATG8 for autophagosome biogenesis, resulting in a dysfunctional mitochondrion with impaired oxidative ability and energy generation. The overall result of this is reduced virulence.

  2. The new Swiss Energy Act

    International Nuclear Information System (INIS)

    Tami, R.

    1999-01-01

    The new Swiss Energy Act and the accompanying regulation enable the instructions given in the poll by the electorate in 1990 -- the Energy Article in the Swiss Constitution -- to be implemented. The Energy Act creates the necessary basis for an advanced and sustainable energy policy. It should contribute to a sufficient, broadly based, dependable, economical and environment-friendly energy supply. The Energy Act and the Energy Regulation entered into force on January 1, 1999. (author)

  3. German Atomic Energy Act turns fifty

    International Nuclear Information System (INIS)

    Schneider, Horst

    2009-01-01

    The German Atomic Energy Act entered into force on January 1, 1960. It turns fifty at the beginning of 2010. Is this a reason to celebrate or rather the opposite? Lawyers, in principle, can view old pieces of legislation from 2 perspectives: On the one hand, aged laws are treated in a spirit of veneration and are celebrated as proven. On the other hand, an anniversary of this kind can be a welcome reason for demands to abolish or, at least, fundamentally renew that law. Over the past half century, the German Atomic Energy Act went through stormy and varied phases both of a legal and a political character. Its 50 th anniversary is likely to spark off very conflicting evaluations as well. A review of legal history shows that the German or, rather, the Federal German Atomic Energy Act (AtG) was not a first-of-its-kind piece of legislation but stemmed from the 1957 EURATOM Treaty, in a way representing a latecomer of that treaty. The Atomic Energy Act experienced a number of important developments throughout its history: - In 1975, compulsory licensing of fuel element factories was introduced. - The back end of the fuel cycle, especially final storage, were incorporated in the Atomic Energy Act comprehensively first in 1976. - In 1985, legislators decided in favor of unlimited nuclear liability. - In 1994 and 1998, only some innovations in special items were introduced under the headings of environmental impact assessment and suitability for repository storage because the controversy about nuclear power did not permit a fundamental alignment towards a more comprehensive modern safety law. - The decision to opt out of the peaceful uses of nuclear power in 2002 drew the final line so far of decisions about directions of nuclear law in a major amendment. In parallel, the decisions by the Federal Constitutional Court and the Federal Administrative Court in the late 1970s and, above all, the 1980s provided important assistance which has remained valid to this day. What is

  4. Atomic Energy Authority Act 1954

    International Nuclear Information System (INIS)

    1954-01-01

    This Act provides for the setting up of an Atomic Energy Authority for the United Kingdom. It also makes provision for the Authority's composition, powers, duties, rights and liabilities, and may amend, as a consequence of the establishment of the Authority and in connection therewith, the Atomic Energy Act, 1946, the Radioactive Substances Act 1948 and other relevant enactments. (NEA) [fr

  5. Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila.

    Science.gov (United States)

    Wen, Jung-Kun; Wang, Yi-Ting; Chan, Chih-Chiang; Hsieh, Cheng-Wen; Liao, Hsiao-Man; Hung, Chin-Chun; Chen, Guang-Chao

    2017-11-16

    Autophagy is essential for maintaining cellular homeostasis and survival under various stress conditions. Autophagy-related gene 9 (Atg9) encodes a multipass transmembrane protein thought to act as a membrane carrier for forming autophagosomes. However, the molecular regulation and physiological importance of Atg9 in animal development remain largely unclear. Here, we generated Atg9 null mutant flies and found that loss of Atg9 led to shortened lifespan, locomotor defects, and increased susceptibility to stress. Atg9 loss also resulted in aberrant adult midgut morphology with dramatically enlarged enterocytes. Interestingly, inhibiting the TOR signaling pathway rescued the midgut defects of the Atg9 mutants. In addition, Atg9 interacted with PALS1-associated tight junction protein (Patj), which associates with TSC2 to regulate TOR activity. Depletion of Atg9 caused a marked decrease in TSC2 levels. Our findings revealed an antagonistic relationship between Atg9 and TOR signaling in the regulation of cell growth and tissue homeostasis.

  6. Atomic Energy Commission Act, 1963

    International Nuclear Information System (INIS)

    1963-01-01

    Promulgated in 1963, the Atomic Energy Commission Act (204) established and vested in the Ghana Atomic Energy Commission the sole responsibility for all matters relating to the peaceful uses of atomic energy in the country. Embodied in the Act are provisions relating to the powers, duties, rights and liabilities of the Commission. (EAA)

  7. The Energy Act 1983

    International Nuclear Information System (INIS)

    1983-01-01

    Part II of This Act came into force on 1 September 1983 and is concerned with nuclear installations. Its main purpose is to amend the Nuclear Installations Act 1965 to give effect to the provisions of two Protocols amending the Paris Convention on nuclear third party liability and the Brussels Convention Supplementary to the Paris Convention respectively. The principal effect of these modifications is to increase the sums available to meet claims for nuclear damage. The United Kingdom is a Party to both Conventions and the provisions of the 1983 Act will enable it to ratify the Protocols. (NEA) [fr

  8. Atomic Energy Act 1989

    International Nuclear Information System (INIS)

    1989-05-01

    This Act, which entered into force on 1 september 1989, contains a series of provisions dealing with different subjects: increase of public financing for British Nuclear Fuels plc, amendment of the Nuclear Installations Act 1965 regarding the powers of the Health and Safety Executive to recover expenses directly from nuclear operators and obligation of the UKAEA to take out insurance or other financial security to cover its liability and finally, measures to enable the UK to ratify the IAEA Convention on Assistance in Case of a Nuclear Accident or Radiological Emergency [fr

  9. ATG16L1

    DEFF Research Database (Denmark)

    Salem, Mohammad; Ammitzboell, Mette; Nys, Kris

    2015-01-01

    Genetic variations in the autophagic pathway influence genetic predispositions to Crohn disease. Autophagy, the major lysosomal pathway for degrading and recycling cytoplasmic material, constitutes an important homeostatic cellular process. Of interest, single-nucleotide polymorphisms in ATG16L1...... (autophagy-related 16-like 1 [S. cerevisiae]), a key component in the autophagic response to invading pathogens, have been associated with an increased risk of developing Crohn disease. The most common and well-studied genetic variant of ATG16L1 (rs2241880; leading to a T300A conversion) exhibits a strong...... association with risk for developing Crohn disease. The rs2241880 variant plays a crucial role in pathogen clearance, resulting in imbalanced cytokine production, and is linked to other biological processes, such as the endoplasmic reticulum stress/unfolded protein response. In this review, we focus...

  10. Atomic Energy Authority Act 1971

    International Nuclear Information System (INIS)

    1971-01-01

    This Act provides for the transfer of property, rights, liabilities and obligations of parts of the undertaking of the United Kingdom Atomic Energy Autority, to two new Compagnies set up for this purpose: the Bristish Nuclear Fuels Limited, and the Radiochemical Centre Limited. Patents licences and registered designs owned by the Autority at the time of the transfer are not included therein. The Act also includes amendments to the Nuclear Installations Act 1965, notably as regards permits to operate granted to a body corporate. Finally, the Schedule to this Act lays down a certain number of provisions relating to security and the preservation of secrets. (NEA) [fr

  11. Atomic Energy Authority Act 1986

    International Nuclear Information System (INIS)

    1986-01-01

    Under this Act the UKAEA is given power to borrow so that it can finance its capital expenditure programme, and will undertake a debt to the Secretary of State for Energy representing its assets. Power is given for the Government to guarantee such borrowing. The UKAEA has been organised financially on the basis of a trading fund. The Act came into force on 1 April 1986. (NEA) [fr

  12. Act to amend cost regulations of the Atomic Energy Act

    International Nuclear Information System (INIS)

    1980-01-01

    Article 21 is replaced by articles 21 to 21b. According to this, fees or reimbursements for expenses for official acts (e.g. decisions, supervisory acts, safeguarding of nuclear fuels) as well as for the use of facilities according to article 9a, section 3, of the Atomic Energy Act (e.g. Laender facilities to collect nuclear waste). (HP) [de

  13. Atomic Energy Amendment Act 1978, No. 31

    International Nuclear Information System (INIS)

    1978-01-01

    This Act amends certain Sections of the Atomic Energy Act 1953. The principal modifications concern the definitions of atomic energy, prescribed substances, the provision and supply of uranium in relation to the functions of the Atomic Energy Commission, compliance with the agreement with the IAEA on the application of safeguards under the Non-Proliferation Treaty as well as with any agreement with any other international organization or another country. The Act also amends the 1953 Act in respect of the control of prescribed substances and repeals the section concerning jurisdiction of courts. (NEA) [fr

  14. Atomic Energy Authority (Weapons Group) Act 1973

    International Nuclear Information System (INIS)

    1973-01-01

    This Act, which came into force on 6th March 1973 and modified Section 2 of the Atomic Energy Authority Act 1954 in respect of the Authority's power to do work on explosive nuclear devices, made provision for the transfer to the Secretary of State for Defence of the Weapons Group of the Atomic Energy Authority. (NEA) [fr

  15. Tenth act amending the German atomic energy act

    International Nuclear Information System (INIS)

    Heller, W.

    2009-01-01

    On January 14, 2009, the German federal government introduced into parliament the 10th Act Amending the Atomic Energy Act. In the first reading in the federal parliament, Federal Minister for the Environment Gabriel emphasized 2 main points: Intensified protection of nuclear facilities and of transports of radioactive substances against unauthorized interventions; transfer by law to the Federal Office for Radiological Protection (BfS) of decommissioning of the Asse mine. Reliability review: The amendment to Sec.12 b of the Atomic Energy Act is to meet the different safety and security conditions after the terrorist attacks on September 11, 2001 in the United States and other terrorist activities afterwards (London, Madrid) also with respect to hazards arising to nuclear facilities and nuclear transports. The bill must be seen in conjunction with the Ordinance on Reliability Reviews under the Atomic Energy Act dated July 1, 1999 which covers reviews of reliability of persons holding special responsibilities. Asse II mine: The competence of the Federal Office for Radiological Protection is achieved by an amendment to Sec.23, Para.1, Number 2, Atomic Energy Act, in which the words ''and for the Asse II mine'' are added after the word ''waste.'' Further proceedings depend on the additional provision in a new Sec.57 b, Atomic Energy Act. Accordingly, the operation and decommissioning of the Asse II mine are subject to the regulations applicable to facilities of the federation pursuant to Sec.9a, Para.3. In this way, Asse II is given the same legal status as the federal waste management facilities. Moreover, it is stipulated that the mine is to be shut down immediately. (orig.)

  16. Atomic Energy Act 1953-1966

    International Nuclear Information System (INIS)

    1970-01-01

    The Atomic Energy Act 1953-1966 establishes the Australian Atomic Energy Commission and lays down its powers, duties, rules of procedure and financing. The members of the Commission are appointed by the Governor-General. It is responsible, inter alia, for all activities covering uranium research, mining and trading as well as for atomic energy development and nuclear plant construction and operation. Its duties also include training of scientific research workers and collection and dissemination of information on atomic energy. For purposes of security, the Act further-more prescribes sanctions in relation to unauthorised acquisition or communication of information on this subject. Finally, the Act repeals the Atomic Energy (Control of Materials) Act 1946 and 1952. (NEA) [fr

  17. Atomic Energy (Miscellaneous Provisions) Act 1981

    International Nuclear Information System (INIS)

    1981-01-01

    This Act extends the power of the United Kingdom Atomic Energy Authority to dispose of shares held by it in any company, and the power of the Secretary of State for Energy to dispose of shares held by him in companies engaged in activities in the field of atomic energy or radioactive substances. (NEA) [fr

  18. Energy policy act 2005 of the USA

    International Nuclear Information System (INIS)

    Marzi, Graziella

    2006-01-01

    The Energy Policy Act 2005 has ended a long energy policy debate in the United States. The new energy legislation aims to assure a stable energy supply and will impact on the structure of the electric sector and the supply of fuels. The paper assesses that while the implications on the electric sector are going to be substantial, those concerning the supply of fuels are expected to bring no significant changes in the present mix of fuels [it

  19. Participation of the public in licensing procedures under the Atomic Energy Act and the Federal Emission Control Act

    International Nuclear Information System (INIS)

    Hett, F.T.

    1994-01-01

    Section 7 of the Atomic Energy Act (AtG), section 4 of the Federal Emission Control Act (BImSchG), the Nuclear Installations Licensing Ordinance (AtVfV), and the Ninth Ordinance on the Implementation of the BImSchG (Principles of the licensing procedure) require participation of the public in the procedure before administrative provisions or decisions are issued. The book presents the legally prescribed steps at which participation of the public is mandatory, for the simple case (only one license on the agenda), and for the multi-stage licensing procedure: preliminary negotiations / filling of applications for a license and filing of documents / public announcement of projects / access to files / objections / preclusion of delayed objections / public hearing and other expert discussions / termination of procedure, decision-making by the authorities / decisions on subdivision of procedure into defined stages / modification of the procedure. The analysis of the functions of participation of the public examines the following goals: information / representation of interests / reconciliation of interests / legitimation / control / protection of rights / support. Finally, the book explains the principles of the Constitution demanding participation of the public: human dignity / democracy / rule of law / anticipated effects of the right to have recourse to the courts / civil rights. (orig./HP) [de

  20. Draft of a Fourth Act amending the Atomic Energy Act

    International Nuclear Information System (INIS)

    1976-01-01

    The bill comprises regulations concerning 1. the handling over and treatment of radioactive waste as well as its final storage under federal adminstration (article 87, section 3, sentence 1 Basic Law), 2. authorizations regarding the issuing of statuatory orders supplementing and extending sections 11 and 12 of the Atomic Energy Act, particulary in aim of the rationalization of licensing and the carrying-out of governmental supervision, 3. supplementing penal provisions. (LN) [de

  1. Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases.

    Science.gov (United States)

    Kauffman, Karlina J; Yu, Shenliang; Jin, Jiaxin; Mugo, Brian; Nguyen, Nathan; O'Brien, Aidan; Nag, Shanta; Lystad, Alf Håkon; Melia, Thomas J

    2018-04-10

    During macroautophagy/autophagy, mammalian Atg8-family proteins undergo 2 proteolytic processing events. The first exposes a COOH-terminal glycine used in the conjugation of these proteins to lipids on the phagophore, the precursor to the autophagosome, whereas the second releases the lipid. The ATG4 family of proteases drives both cleavages, but how ATG4 proteins distinguish between soluble and lipid-anchored Atg8 proteins is not well understood. In a fully reconstituted delipidation assay, we establish that the physical anchoring of mammalian Atg8-family proteins in the membrane dramatically shifts the way ATG4 proteases recognize these substrates. Thus, while ATG4B is orders of magnitude faster at processing a soluble unprimed protein, all 4 ATG4 proteases can be activated to similar enzymatic activities on lipid-attached substrates. The recognition of lipidated but not soluble substrates is sensitive to a COOH-terminal LIR motif both in vitro and in cells. We suggest a model whereby ATG4B drives very fast priming of mammalian Atg8 proteins, whereas delipidation is inherently slow and regulated by all ATG4 homologs.

  2. New US energy policy act in force

    International Nuclear Information System (INIS)

    Heller, W.

    2005-01-01

    The United States of America is accused by politicians of the German Red-Green federal government, but also by the EU, of not caring enough about climate protection. This allegation is fueled, above all, by the refusal of the United States to sign the Kyoto Protocol of the UN Climate Framework Convention of 1997. However, the US is not idle in this respect. In late July, the United States together with China, India, Japan, South Korea and Australia agreed on an Asia-Pacific Partnership on Clean Development and Climate. Almost at the same time, on July 29, 2005, after more than five years of debate, the US Congress adopted new energy legislation (A Bill to Ensure Jobs for the Future with Secure and Reliable Energy - the Energy Policy Act of 2005). The holistic aspect in this piece of US legislation covers nearly the whole field of energy policy. The Act encompasses these areas: - energy efficiency, - renewable energies, - oil and natural gas, - clean coal, - nuclear power, - vehicles and fuels, - hydrogen, - electricity, - research and development. With its new Energy Policy Act, the United States has paved the way politically for making energy supply in the world's largest industrialized national securer and safer on a technical basis and less pollutant for the environment and the climate. (orig.)

  3. Atomic Energy Act with ordinances. 16. ed.

    International Nuclear Information System (INIS)

    Ziegler, E.

    1992-01-01

    The convenient edition contains the entire body of German atomic energy and radiation protection laws in their updated version as of June 1992. Thus it also takes the amendments of the Atomic Energy Act (Article 22 Paragraph 1 Sentence 1 and Paragraph 3 as well as Article 46 Paragraph 3 Atomic Energy Act) into account on the basis of the Law on the Establishment of a Federal Export Office from February 28, 1992 (Code of Federal Laws I, pp. 376 ff). As a result of this law, which became effective as of April 1, 1992, within the scope of business of the Federal Ministry for Economic Affairs, a federal export office was established which was endowed with the status of a federal agency. This office is in charge of administrative and supervisory tasks on the federal level. Within the framework of the atomic energy law this agency is in charge of export and import permits as well as the supervision of the export and import of nuclear fuel and other radioactive materials. (orig./HP) [de

  4. Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes

    Directory of Open Access Journals (Sweden)

    C. A. Bader

    2015-11-01

    Full Text Available Autophagy is an intracellular recycling and degradation process, which is important for energy metabolism, lipid metabolism, physiological stress response and organism development. During Drosophila development, autophagy is up-regulated in fat body and midgut cells, to control metabolic function and to enable tissue remodelling. Atg9 is the only transmembrane protein involved in the core autophagy machinery and is thought to have a role in autophagosome formation. During Drosophila development, Atg9 co-located with Atg8 autophagosomes, Rab11 endosomes and Lamp1 endosomes-lysosomes. RNAi silencing of Atg9 reduced both the number and the size of autophagosomes during development and caused morphological changes to amphisomes/autolysosomes. In control cells there was compartmentalised acidification corresponding to intraluminal Rab11/Lamp-1 vesicles, but in Atg9 depleted cells there were no intraluminal vesicles and the acidification was not compartmentalised. We concluded that Atg9 is required to form intraluminal vesicles and for localised acidification within amphisomes/autolysosomes, and consequently when depleted, reduced the capacity to degrade and remodel gut tissue during development.

  5. The role of the Government Energy Efficiency Act in the National Energy Act of 1992

    International Nuclear Information System (INIS)

    Good, L.; Williams, D.R.

    1993-01-01

    Last year Senator John Glenn's Government Energy Efficiency Act to reform energy management in the Federal Government was adopted entirely into the Senate's comprehensive energy bill. This year key portions of an equivalent bill were incorporated into the House of Representatives comprehensive energy bill after intensive lobbying by AEE's National Capital Chapter. According to a House staffer who played a key role in the bill, the section on energy manager training was included as a direct result of the Chapter's persuasion. Each bill passed in its respective house. At the time of this writing, in the spring of 1992, the two houses are scheduled to go into conference and attempt to merge their separate bills into one National Energy Act of 1992. The 102nd Congress seems determined to establish a national energy policy before election time, but the two houses take very different approaches to the problem, The bill could be voted into law during or just before the 15th World Energy Engineering Congress (WEEC). This paper will discuss some of the strengths and loopholes that apply to the Federal sector. The presentation of this paper at WEEC in October will bring AEE members up to the minute on these developments

  6. Amendment of the Energy Economy Act. Novellierung des Energiewirtschaftsgesetzes

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-20

    The Federal Association of German Industry deliberates on the reform of the Energy Economy Act, arriving at the following intermediate result that is to be discussed by the member associations. The following might be essential points for the attitude of the industry regarding the reform of the energy economy act: deregulation, qualitative modernization, concentration on electric power and gas, differentiated regulations for power and gas, limitation of municipal influence (outside the scope of the energy economy act: reform of the municipal right of way), secure power and gas supply at internationally competitive prices. This is followed by considerations regarding the individual provisions of the energy economy act and their discussion. (orig./HSCH).

  7. Department of Energy Recovery Act Investment in Biomass Technologies

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-11-01

    The American Recovery and Reinvestment Act of 2009 (Recovery Act) provided more than $36 billion to the Department of Energy (DOE) to accelerate work on existing projects, undertake new and transformative research, and deploy clean energy technologies across the nation. Of this funding, $1029 million is supporting innovative work to advance biomass research, development, demonstration, and deployment.

  8. Energy for tomorrow's world. Acting now

    International Nuclear Information System (INIS)

    2000-01-01

    The statement 2000 of WEC (World Energy Council) is an extremely important document, committed to overcoming the energy shortage where it is found, pointing out, from one hand, the importance of quality and safety in the energy supply, and, from the other hand, the necessity of minimizing the impact of energy development on the environment and mankind health [it

  9. Atomic Energy Control Act, c A.19, s.1

    International Nuclear Information System (INIS)

    1985-01-01

    The Revised Statutes of Canada 1985 entered into force on 12 December 1988, revoking the previous Atomic Energy Control Act and replacing it with a new version. The new Act (Chapter A-16 of the Revised Statutes) updates the previous text and makes some linguistic corrections. The Atomic Energy Control Act establishes the Atomic Energy Control Board and sets out its duties and powers which include, in particular, the making of regulations for developing, controlling and licensing the production, application and use of atomic energy [fr

  10. The ''Article Act'' - a substitute for the miscarried energy consensus?

    International Nuclear Information System (INIS)

    Knott, G.

    1994-01-01

    A prerequisite for arriving at a long-term energy policy is that all political parties come to an energy consensus. This paper reviews the chronology of the energy consensus negatiations, their failure, and the consequent energy-political rerouting which is to be realised by an act securing hard coal a share in electricity generation and amending the Atomic Energy Act (termed 'Article Act'). The Article Act is an attempt at a binding definition of central issues of the energy consensus talks even in the absence of an all-party agreement. It is particularly noteworthy that the bill makes mention of both coal and nuclear energy, reviving this link-up between the two energy sources already decined lost. The German electricity industry considers the provisions on atomic energy law contained in the Article Act insufficient for securing already existing power plants an untroubled future and for providing the investment climate needed by the manufacturing industry. To the electricity industry the main problems lie in the execution deficits at the Laender level, but these are not affected by the Article Act. It is concluded that an all-party consensus on an answerable nuclear energy utilisation will have to be found by 1995 at the latest in order to give the manufacturing industry the go-alread for continuing research and provide electricity producers with a sound basis for investment decisions. (orig./HSCH) [de

  11. An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity.

    Science.gov (United States)

    Xiao, Yuzhong; Deng, Yalan; Yuan, Feixiang; Xia, Tingting; Liu, Hao; Li, Zhigang; Chen, Shanghai; Liu, Zhixue; Ying, Hao; Liu, Yi; Zhai, Qiwei; Guo, Feifan

    2017-06-03

    ATF4 (activating transcription factor 4) is an important transcription factor that has many biological functions, while its role in hypothalamic POMC (pro-opiomelanocortin-α) neurons in the regulation of energy homeostasis has not been explored. We recently discovered that mice with an Atf4 deletion specific to POMC neurons (PAKO mice) are lean and have higher energy expenditure. Furthermore, these mice are resistant to high-fat diet (HFD)-induced obesity and obesity-related metabolic disorders. Mechanistically, we found the expression of ATG5 (autophagy-related 5) is upregulated in POMC neurons of PAKO mice, and ATF4 regulates ATG5 expression by binding directly to its promoter. Mice with Atf4 and Atg5 double knockout in POMC neurons have reduced energy expenditure and gain more fat mass compared with PAKO mice under a HFD. Finally, the effect of Atf4 knockout in POMC neurons is possibly mediated by enhanced ATG5-dependent macroautophagy/autophagy and α-melanocyte-stimulating hormone (α-MSH) production in the hypothalamus. Together, this work not only identifies a beneficial role for ATF4 in hypothalamic POMC neurons in the regulation of obesity, but also provides a new potential therapeutic target for obesity and obesity-related metabolic diseases.

  12. Energy for Tomorrow's World - Acting Now

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-06-01

    WEC, with over 75 years of history, is concentrating on study and research about production and utilization of sustainable energy and regional and technology program for the maximum benefit of human beings. WEC is a global multi energy organization with supports from private companies, public corporations, governments, academics and famous people in around one hundred countries. The activities of WEC include major energy production and consumption market. 18 figs., 17 tabs.

  13. Characterization of a novel autophagy-specific gene, ATG29

    International Nuclear Information System (INIS)

    Kawamata, Tomoko; Kamada, Yoshiaki; Suzuki, Kuninori; Kuboshima, Norihiro; Akimatsu, Hiroshi; Ota, Shinichi; Ohsumi, Mariko; Ohsumi, Yoshinori

    2005-01-01

    Autophagy is a process whereby cytoplasmic proteins and organelles are sequestered for bulk degradation in the vacuole/lysosome. At present, 16 ATG genes have been found that are essential for autophagosome formation in the yeast Saccharomyces cerevisiae. Most of these genes are also involved in the cytoplasm to vacuole transport pathway, which shares machinery with autophagy. Most Atg proteins are colocalized at the pre-autophagosomal structure (PAS), from which the autophagosome is thought to originate, but the precise mechanism of autophagy remains poorly understood. During a genetic screen aimed to obtain novel gene(s) required for autophagy, we identified a novel ORF, ATG29/YPL166w. atg29Δ cells were sensitive to starvation and induction of autophagy was severely retarded. However, the Cvt pathway operated normally. Therefore, ATG29 is an ATG gene specifically required for autophagy. Additionally, an Atg29-GFP fusion protein was observed to localize to the PAS. From these results, we propose that Atg29 functions in autophagosome formation at the PAS in collaboration with other Atg proteins

  14. P.L. 96-294, "Energy Security Act" (1980)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-12-13

    Declares it to be the purpose of this title to reduce dependence on foreign energy resources by producing synthetic fuel. Part A: Development of Synthetic Fuel Under the Defense Production Act of 1950 - Defense Production Act Amendments of 1980 - Amends the Defense Production Act of 1950 to include within the policy objectives of such Act Government preparedness to contend with foreign actions which could reduce or terminate the availability of material, including energy, which is crucial to national defense. States that greater independence in domestic energy supplies is necessary to national defense preparedness. Designates "energy" as a "strategic and critical material." States that such designation shall not give the President any authority: (1) for the mandatory allocation or pricing of any fuel or feedstock; or (2) to engage in the production of energy in any manner whatsoever, except for synthetic fuel production.

  15. Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.

    Science.gov (United States)

    Qi, Shiqian; Kim, Do Jin; Stjepanovic, Goran; Hurley, James H

    2015-10-06

    The ULK1 complex, consisting of the ULK1 protein kinase itself, FIP200, Atg13, and Atg101, controls the initiation of autophagy in animals. We determined the structure of the complex of the human Atg13 HORMA (Hop1, Rev7, Mad2) domain in complex with the full-length HORMA domain-only protein Atg101. The two HORMA domains assemble with an architecture conserved in the Mad2 conformational heterodimer and the S. pombe Atg13-Atg101 HORMA complex. The WF finger motif that is essential for function in human Atg101 is sequestered in a hydrophobic pocket, suggesting that the exposure of this motif is regulated. Benzamidine molecules from the crystallization solution mark two hydrophobic pockets that are conserved in, and unique to, animals, and are suggestive of sites that could interact with other proteins. These features suggest that the activity of the animal Atg13-Atg101 subcomplex is regulated and that it is an interaction hub for multiple partners. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Energy Policy Act of 2005 and Underground Storage Tanks (USTs)

    Science.gov (United States)

    The Energy Policy Act of 2005 significantly affected federal and state underground storage tank programs, required major changes to the programs, and is aimed at reducing underground storage tank releases to our environment.

  17. Atomic Energy Amendment Act 1987 - No 5 of 1987

    International Nuclear Information System (INIS)

    1987-01-01

    This Act modifies substantially the Atomic Energy Act 1953 as already amended. It repeals almost all of the existing Atomic Energy Act, including the provisions establishing the Australian Atomic Energy Commission and the security provisions. A new authority is created under separate legislation to replace the Commission: the Australian Nuclear Science and Technology Organization. The only parts of the Act which remain are the sections covering the authorization of the Ranger Project and the Commonwealth title to uranium in the Northern Territory; and the requirement for reporting of discoveries of prescribed substances (uranium, thorium, i.e. any substance which may be used for production of atomic energy) and information on their production. Certain definitions have also been kept. (NEA) [fr

  18. Atomic Energy Authority Act, No. 19 of 1969

    International Nuclear Information System (INIS)

    1969-01-01

    Act to provide for the establishment of an Atomic Energy Authority and an advisory committee to advise such authority, to specify the power, duties, rights and functions of such authority, and to provide for matters connected therewith or incidental thereto

  19. Legislation in Hungary. Implementation of the Act on Atomic Energy

    International Nuclear Information System (INIS)

    Szonyi, Z.

    1999-01-01

    The presentation gives a short overview of the history and development of the Hungarian nuclear regulatory regime. The new Act on Atomic Energy is a consequence of the significant internal and international changes. The main characteristic of the Act represent the new expectations and challenges of the nuclear community and the solid and reliable Hungarian legal solutions. The competences, duties and responsibilities of Hungarian Atomic Energy Authority and of the joining other relevant ministries and the complete regulatory framework guarantee the enforcement of the requirements set by the Act.(author)

  20. P.L. 102-486, "Energy Policy Act" (1992)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-12-13

    Amends the Energy Conservation and Production Act to set a deadline by which each State must certify to the Secretary of Energy whether its energy efficiency standards with respect to residential and commercial building codes meet or exceed those of the Council of American Building Officials (CABO) Model Energy Code, 1992, and of the American Society of Heating, Refrigerating, and Air-Conditioning Engineers, respectively.

  1. Detection of a novel specificity (CTLA-4) in ATG/TMG globulins and sera from ATG-treated leukemic patients.

    Science.gov (United States)

    Pistillo, Maria Pia; Tazzari, Pier Luigi; Bonifazi, Francesca; Bandini, Giuseppe; Kato, Tomohiro; Matsui, Toshihiro; Nishioka, Kusuki; Conte, Roberto; Ferrara, Giovanni Battista

    2002-04-27

    T-cell costimulation has been shown to provide positive signals for T-cell activation and generation of effector activity. In this study, we analyzed the presence of antibodies (Abs) against the T-lymphocyte costimulatory molecules CD28, CTLA-4, CD80, and CD86 in anti-T-lymphocyte (ATG) and antithymocyte (TMG) globulin preparations to address their mechanism of action. We focused our attention on the role of CTLA-4-specific Abs in the immunosuppressive effect of ATG/TMG, because anti-CTLA-4 agonistic Abs may suppress T-cell proliferation and nonagonistic Abs may lead to T-cell depletion through an Ab-dependent cell cytotoxicity mechanism. ATG/TMG and patients' sera were tested for binding to recombinant human costimulatory molecules by ELISA techniques. CTLA-4 specificity was also analyzed by cytoplasmic immunofluorescence staining of a CTLA-4 transfectant by competitive inhibition immunofluorescence and by cell proliferation assay in allogeneic mixed lymphocyte reaction (MLR). Either ATG or TMG predominantly contained anti-CTLA-4 Abs, with higher reactivity in ATG followed by anti-CD86 and -CD28 Abs, whereas anti-CD80 Abs were found only in ATG. Anti-CTLA-4 Abs present in ATG/TMG recognized the native form of CTLA-4 molecule, and their removal reduced the effect of ATG in an allogeneic MLR. Kinetic studies indicated that such Abs were present in the sera of 12 ATG-treated leukemic patients up to 21 days after ATG administration. These data suggest that the novel anti-CTLA-4 Abs found in ATG may greatly contribute to its immunosuppressive effect, thus accounting for the absence of rejection and exceptionally low incidence of graft-versus-host disease in the group of patients analyzed.

  2. Depletion of autophagy-related genes ATG3 and ATG5 in Tenebrio molitor leads to decreased survivability against an intracellular pathogen, Listeria monocytogenes.

    Science.gov (United States)

    Tindwa, Hamisi; Jo, Yong Hun; Patnaik, Bharat Bhusan; Noh, Mi Young; Kim, Dong Hyun; Kim, Iksoo; Han, Yeon Soo; Lee, Yong Seok; Lee, Bok Luel; Kim, Nam Jung

    2015-01-01

    Macroautophagy (autophagy) is an evolutionarily conserved catabolic process involved in physiological and developmental processes including cell survival, death, and innate immunity. Homologues of most of 36 originally discovered autophagy-related (ATG) genes in yeast have been characterized in higher eukaryotes including insects. In this study, the homologues of ATG3 (TmATG3) and ATG5 (TmATG5) were isolated from the coleopteran beetle, Tenebrio molitor by expressed sequence tag and RNAseq approaches. The cDNA of TmATG3 and TmATG5 comprise open-reading frame sizes of 963 and 792 bp encoding polypeptides of 320 and 263 amino acid residues, respectively. TmATG3 and TmATG5 mRNA are expressed in all developmental stages, and mainly in fat body and hemocytes of larvae. TmATG3 and TmATG5 showed an overall sequence identity of 58-95% to other insect Atg proteins. There exist clear one-to-one orthologs of TmATG3 and TmATG5 in Tribolium and that they clustered together in the gene tree. Depletion of TmATG3 and TmATG5 by RNA interference led to a significant reduction in survival ability of T. molitor larvae against an intracellular pathogen, Listeria monocytogenes. Six days post-Listeria challenge, the survival rate in the dsEGFP-injected (where EGFP is enhanced green fluorescent protein) control larvae was significantly higher (55%) compared to 4 and 3% for TmATG3 and TmATG5 double-stranded RNA injected larvae, respectively. These data suggested that TmATG3 and TmATG5 may play putative role in mediating autophagy-based clearance of Listeria in T. molitor model. © 2014 Wiley Periodicals, Inc.

  3. Local policies for DSM: the UK's home energy conservation act

    International Nuclear Information System (INIS)

    Jones, E.; Leach, M.

    2000-01-01

    Residential energy use accounts for approximately 28 per cent of total primary energy use in the UK, with consumption in this sector forecast to increase due partly to expanding numbers of households. Finding ways to reduce residential energy consumption must form a key part of the climate change strategies of the UK and all developed countries. In 1995, an innovative piece of legislation was passed in the UK, devolving residential energy efficiency responsibility to local government. Under 'The Home Energy Conservation Act' (HECA), local authorities are obliged to consider the energy efficiency of private as well as public housing stock. Authorities were given a duty to produce a strategy for improving residential energy efficiency in their area by 30 per cent in the next 10-15 years. This paper describes the enormous variation in the quality of local authorities' strategies and discusses reasons for this variation. Based on a nationwide survey of HECA lead officers, it considers the opportunities and constraints facing local authorities, and what has been achieved to-date under the Act. It also examines how HECA fits into the UK's national energy policy and explains the roles of other institutions across the public, private and voluntary sector in facilitating implementation of the Act. Finally, the paper considers how other countries can learn from the UK's HECA experience and can use the Act as a template to apply the principle of subsidiarity to this area of environmental policy. (Author)

  4. Distribution effects of the renewable energies act; Verteilungswirkungen des EEG

    Energy Technology Data Exchange (ETDEWEB)

    Bardt, Hubertus; Niehues, Judith [Institut der deutschen Wirtschaft Koeln, Koeln (Germany)

    2013-09-15

    The Renewal Energies Act has so far been one of the cornerstones of the energy revolution. As a result of the Act the production of electricity from renewable sources has been considerably increased. As the most expensive forms of renewable energies have grown fastest, average costs have not shrunk but have risen significantly. The ongoing growth led to increasing subsidies for renewable energies and growing costs for electricity consumers in business and private households. It would be insufficient to look at absolute cost developments only, as distribution effects may be critical. As electricity consumption only slightly depends on household income, higher income leads to lower significance of electricity costs. Therefore, low income households bear a relatively higher burden of costs for renewable energies. Furthermore, wealthy households could benefit from the subsidies as they can invest in renewable energy systems.

  5. Combination erlotinib-cisplatin and Atg3-mediated autophagy in erlotinib resistant lung cancer.

    Directory of Open Access Journals (Sweden)

    Jasmine G Lee

    Full Text Available Tyrosine kinase inhibitors such as erlotinib are commonly used as a therapeutic agent against cancer due to its relatively low side-effect profile and, at times, greater efficacy. However, erlotinib resistance (ER in non-small cell lung cancer is being recognized as a major problem. Therefore, understanding the mechanism behind ER and developing effective regimens are needed. Autophagy's role in cancer has been controversial and remains unclear. In this study, we examined the effectiveness of low dose erlotinib-cisplatin combination in erlotinib resistant lung adenocarcinoma (ERPC9 cells and the role of autophagy in ER. ERPC9 cells were established from erlotinib sensitive PC9 cells. Appropriate treatments were done over two days and cell survival was quantified with Alamar Blue assay. LC3II and regulatory proteins of autophagy were measured by western blot. Small interfering RNA (siRNA was utilized to inhibit translation of the protein of interest. In ERPC9 cells, combination treatment induced synergistic cell death and a significant decrease in autophagy. At baseline, ERPC9 cells had a significantly higher LC3II and lower p-mTOR levels compared to PC9 cells. The addition of rapamycin increased resistance and 3-methyladenine sensitized ERPC9 cells, indicating autophagy may be acting as a protective mechanism. Further examination revealed that ERPC9 cells harbored high baseline Atg3 levels. The high basal Atg3 was targeted and significantly lowered with combination treatment. siRNA transfection of Atg3 resulted in the reversal of ER; 42.0% more cells died in erlotinib-alone treatment with transfection compared to non-transfected ERPC9 cells. We reveal a novel role for Atg3 in the promotion of ER as the inhibition of Atg3 translation was able to result in the re-sensitization of ERPC9 cells to erlotinib-alone treatment. Also, we demonstrate that combination erlotinib-cisplatin is an effective treatment against erlotinib resistant cancer by

  6. Foot-and-mouth disease virus infection suppresses autophagy and NF-кB antiviral responses via degradation of ATG5-ATG12 by 3Cpro.

    Science.gov (United States)

    Fan, Xuxu; Han, Shichong; Yan, Dan; Gao, Yuan; Wei, Yanquan; Liu, Xiangtao; Liao, Ying; Guo, Huichen; Sun, Shiqi

    2017-01-19

    Autophagy-related protein ATG5-ATG12 is an essential complex for the autophagophore elongation in autophagy, which has been reported to be involved in foot-and-mouth disease virus (FMDV) replication. Previous reports show that ATG5-ATG12 positively or negatively regulates type I interferon (IFN-α/β) pathway during virus infection. In this study, we found that FMDV infection rapidly induced LC3 lipidation and GFP-LC3 subcellular redistribution at the early infection stage in PK-15 cells. Along with infection time course to 2-5 h.p.i., the levels of LC3II and ATG5-ATG12 were gradually reduced. Further study showed that ATG5-ATG12 was degraded by viral protein 3C pro , demonstrating that FMDV suppresses autophagy along with viral protein production. Depletion of ATG5-ATG12 by siRNA knock down significantly increased the FMDV yields, whereas overexpression of ATG5-ATG12 had the opposite effects, suggesting that degradation of ATG5-ATG12 benefits virus growth. Further experiment showed that overexpression of ATG5-ATG12 positively regulated NF-кB pathway during FMDV infection, marked with promotion of IKKα/β phosphorylation and IκBα degradation, inhibition of p65 degradation, and facilitation of p65 nuclear translocation. Meanwhile, ATG5-ATG12 also promoted the phosphorylation of TBK1 and activation of IRF3 via preventing TRAF3 degradation. The positive regulation of NF-кB and IRF3 pathway by ATG5-ATG12 resulted in enhanced expression of IFN-β, chemokines/cytokines, and IFN stimulated genes, including anti-viral protein PKR. Altogether, above findings suggest that ATG5-ATG12 positively regulate anti-viral NF-κB and IRF3 signaling during FMDV infection, thereby limiting FMDV proliferation. FMDV has evolved mechanisms to counteract the antiviral function of ATG5-ATG12, via degradation of them by viral protein 3C pro .

  7. The type of ATG matters -- natural killer cells are influenced differentially by Thymoglobulin, Lymphoglobulin and ATG-Fresenius.

    Science.gov (United States)

    Penack, Olaf; Fischer, Lars; Gentilini, Chiara; Nogai, Axel; Muessig, Arne; Rieger, Kathrin; Ganepola, Susanne; Thiel, Eckhard; Uharek, Lutz

    2007-11-01

    Although ATG is frequently used in hematopoietic stem cell transplantation and solid organ transplantation, little is known on its effects on NK cells, which mediate important functions in post-transplantation immunology. We incubated peripheral blood lymphocytes of healthy donors with Thymoglobulin, Lymphoglobulin or ATG-Fresenius. Cell death and apoptosis of NK cells and T cells were determined by flow cytometry using propidium iodide and Annexin V. As expected, there were no significant differences between the different ATGs regarding their T cell toxicity. Surprisingly, we found profound differences between the different ATGs regarding their impact on NK cells: In clinically relevant concentrations Lymphoglobulin had less toxic effects on NK cells as compared to Thymoglobulin or ATG-Fresenius: the median percentages of apoptotic or necrotic NK cells in response to 1 mug/ml Lymphoglobulin, ATG-Fresenius and Thymoglobulin were 2%, 35% and 38%, respectively (pFresenius regarding the preservation of NK cell mediated immunity. Randomized trials addressing the impact of different ATGs on lymphocyte subpopulations in the clinical setting are urgently warranted.

  8. The autophagy-related genes BbATG1 and BbATG8 have different functions in differentiation, stress resistance and virulence of mycopathogen Beauveria bassiana

    Science.gov (United States)

    Ying, Sheng-Hua; Liu, Jing; Chu, Xin-Ling; Xie, Xue-Qin; Feng, Ming-Guang

    2016-01-01

    Autophagy-related proteins play significantly different roles in eukaryotes. In the entomopathogenic fungus Beauveria bassiana, autophagy is associated with fungal growth and development. BbATG1 (a serine/threonine protein kinase) and BbATG8 (a ubiquitin-like protein) have similar roles in autophagy, but different roles in other processes. Disruption mutants of BbATG1 and BbATG8 had impaired conidial germination under starvation stress. The mutant ΔBbATG8 exhibited enhanced sensitivity to oxidative stress, while a ΔBbATG1 mutant did not. BbATG1 and BbATG8 showed different roles in spore differentiation. The blastospore yield was reduced by 70% and 92% in ΔBbATG1 and ΔBbATG8 mutants, respectively, and the double mutant had a reduction of 95%. Conidial yield was reduced by approximately 90% and 50% in ΔBbATG1 and ΔBbATG8 mutants, respectively. A double mutant had a reduction similar to ΔBbATG1. Additionally, both BbATG1 and BbATG8 affected the levels of conidial protein BbCP15p required for conidiation. The virulence of each autophagy-deficient mutant was considerably weakened as indicated in topical and intrahemocoel injection assays, and showed a greater reduction in topical infection. However, BbATG1 and BbATG8 had different effects on fungal virulence. Our data indicate that these autophagy-related proteins have different functions in fungal stress response, asexual development and virulence. PMID:27197558

  9. Enraf Series 854 advanced technology gauge (ATG) acceptance test procedure

    International Nuclear Information System (INIS)

    Huber, J.H.

    1996-01-01

    This Acceptance Test Procedure was written to test the Enraf Series 854 Advanced Technology Gauge (ATG) prior to installation in the Tank Farms. The procedure sets various parameters and verifies that the gauge is functional

  10. ATG13: just a companion, or an executor of the autophagic program?

    Science.gov (United States)

    Alers, Sebastian; Wesselborg, Sebastian; Stork, Björn

    2014-06-01

    During the past 20 years, autophagy signaling has entered the main stage of the cell biological theater. Autophagy represents an intracellular degradation process that is involved in both the bulk recycling of cytoplasmic components and the selective removal of organelles, protein aggregates, or intracellular pathogens. The understanding of autophagy has been greatly facilitated by the characterization of the molecular machinery governing this process. In yeast, initiation of autophagy is controlled by the Atg1 kinase complex, which is composed of the Ser/Thr kinase Atg1, the adaptor protein Atg13, and the ternary complex of Atg17-Atg31-Atg29. In vertebrates, the orthologous ULK1 kinase complex contains the Ser/Thr kinase ULK1 and the accessory proteins ATG13, RB1CC1, and ATG101. Among these components, Atg1/ULK1 have gained major attention in the past, i.e., for the identification of upstream regulatory kinases, the characterization of downstream substrates controlling the autophagic flux, or as a druggable target for the modulation of autophagy. However, accumulating data indicate that the function of Atg13/ATG13 has been likely underestimated so far. In addition to ensuring proper Atg1/ULK1 recruitment and activity, this adaptor molecule has been implicated in ULK1-independent autophagy processes. Furthermore, recent data have identified additional binding partners of Atg13/ATG13 besides the components of the Atg1/ULK1 complex, e.g., Atg8 family proteins or acidic phospholipids. Therefore, in this review we will center the spotlight on Atg13/ATG13 and summarize the role that Atg13/ATG13 assumes in the autophagy stage play.

  11. ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy.

    Science.gov (United States)

    Antonelli, Martina; Strappazzon, Flavie; Arisi, Ivan; Brandi, Rossella; D'Onofrio, Mara; Sambucci, Manolo; Manic, Gwenola; Vitale, Ilio; Barilà, Daniela; Stagni, Venturina

    2017-03-28

    The efficacy of Ataxia-Telangiectasia Mutated (ATM) kinase signalling inhibition in cancer therapy is tempered by the identification of new emerging functions of ATM, which suggests that the role of this protein in cancer progression is complex. We recently demonstrated that this tumor suppressor gene could act as tumor promoting factor in HER2 (Human Epidermal Growth Factor Receptor 2) positive breast cancer. Herein we put in evidence that ATM expression sustains the proportion of cells with a stem-like phenotype, measured as the capability to form mammospheres, independently of HER2 expression levels. Transcriptomic analyses revealed that, in mammospheres, ATM modulates the expression of cell cycle-, DNA repair- and autophagy-related genes. Among these, the silencing of the autophagic gene, autophagy related 4C cysteine peptidase (ATG4C), impairs mammosphere formation similarly to ATM depletion. Conversely, ATG4C ectopic expression in cells silenced for ATM expression, rescues mammospheres growth. Finally, tumor array analyses, performed using public data, identify a significant correlation between ATM and ATG4C expression levels in all human breast cancer subtypes, except for the basal-like one.Overall, we uncover a new connection between ATM kinase and autophagy regulation in breast cancer. We demonstrate that, in breast cancer cells, ATM and ATG4C are essential drivers of mammosphere formation, suggesting that their targeting may improve current approaches to eradicate breast cancer cells with a stem-like phenotype.

  12. Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum.

    Directory of Open Access Journals (Sweden)

    Kei Kitamura

    Full Text Available Autophagy is a membrane-mediated degradation process, which is governed by sequential functions of Atg proteins. Although Atg proteins are highly conserved in eukaryotes, protozoa possess only a partial set of Atg proteins. Nonetheless, almost all protozoa have the complete factors belonging to the Atg8 conjugation system, namely, Atg3, Atg4, Atg7, and Atg8. Here, we report the biochemical properties and subcellular localization of the Atg8 protein of the human malaria parasite Plasmodium falciparum (PfAtg8. PfAtg8 is expressed during intra-erythrocytic development and associates with membranes likely as a lipid-conjugated form. Fluorescence microscopy and immunoelectron microscopy show that PfAtg8 localizes to the apicoplast, a four membrane-bound non-photosynthetic plastid. Autophagosome-like structures are not observed in the erythrocytic stages. These data suggest that, although Plasmodium parasites have lost most Atg proteins during evolution, they use the Atg8 conjugation system for the unique organelle, the apicoplast.

  13. Renewable energies heat act and government grants in Germany

    International Nuclear Information System (INIS)

    Nast, M.

    2010-01-01

    In Germany renewable energies in the heat market are promoted by the Renewable Energies Heat Act (EEWaermeG) and by government grants. Ultimately, these two instruments are not only about short-term market success, but rather about the perspectives of climate protection and resource conservation. The focus of this report is therefore on the long-term significance of the current design of government grants and EEWaermeG. We will introduce and discuss the quantitative goals and structural changes strived for as well as - on a slightly shorter time horizon - the quality assurance regulations which must accompany the steady and stable growth of renewable energies. In the process, we will elaborate in particular on heat pumps, which have recently been added to the government support programme, along with solar collectors. Some explanations regarding the structural relationships between EEWaermeG and government grants round off this contribution. (author)

  14. Atomic Energy Amendment Act (No.2) 1978, No. 182 of 1978

    International Nuclear Information System (INIS)

    1978-01-01

    This Act amends the Atomic Energy Act 1953 by introducing detailed rules concerning the revocation, modification and assignment of an authorization under the latter Act to carry on operations concerned with the mining of prescribed substances. (NEA) [fr

  15. Preliminary assessment of fleets covered by the Energy Policy Act

    Energy Technology Data Exchange (ETDEWEB)

    Hu, P.S.; Davis, S.C.; Wang, M.Q. [and others

    1994-12-31

    To facilitate the goal of decreasing oil imports by 10 percent by the year 2000 and 30 percent by 2010, two sections of the Energy Policy Act encourage and mandate alternative fuel vehicles in the acquisition of fleet vehicles. The first step in estimating the contribution of these mandates toward meeting the aforementioned goal entails identifying affected fleets. This paper presents a preliminary assessment of potential vehicle fleet coverage. Only a limited number of companies in the methanol, ethanol, and hydrogen industries are likely to quality for this mandate. Whereas, many of the oil producers, petroleum refiners, and electricity companies are likely to be regulated.

  16. Wave Loadings Acting on an Innovative Breakwater for Energy Production

    DEFF Research Database (Denmark)

    Vicinanza, Diego; Ciardulli, F.; Buccino, M.

    2011-01-01

    The paper reports on 2D small scale experiments conducted to investigate wave loadings acting on a pilot project of device for the conversion of wave energy into electricity. The conversion concept is based on the overtopping principle and the structure is worldwide known with the acronym SSG....... The hydraulic model tests have been carried out at the LInC laboratory of the University of Naples Federico II using random waves. Results indicate wave overtopping is able to cause a sudden inversion of vertical force under wave crest, so that it is alternatively upward and downward directed over a short time...

  17. Wave loadings acting on Overtopping Breakwater for Energy Conversion

    DEFF Research Database (Denmark)

    Vicinanza, Diego; Nørgaard, Jørgen Harck; Contestabile, Pasquale

    2013-01-01

    distributions. Load measurements were compared with the most used prediction method for traditional breakwaters, available in the Coastal Engineering Manual (U.S. Army Corps of Engineers, 2002). These results suggest to use the experimental data as design loadings since the design criteria for the innovative......Any kind of Wave Energy Converter (WEC) requires information on reliability of technology and on time required for the return of the investment (reasonable payback). The structural response is one of the most important parameters to take in to account for a consistent assessment on innovative...... devices. This paper presents results on wave loading acting on an hybrid WEC named Overtopping BReakwater for Energy Conversion (OBREC). The new design is based on the concept of an integration between a traditional rubble mound breakwater and a front reservoir designed to store the wave overtopping from...

  18. Energy Independence and Security Act of 2007: A Summary of Major Provisions

    National Research Council Canada - National Science Library

    Sissine, Fred

    2007-01-01

    The Energy Independence and Security Act (P.L. 110-140, H.R. 6) is an omnibus energy policy law that consists mainly of provisions designed to increase energy efficiency and the availability of renewable energy...

  19. Atg21p is essential for macropexophagy and microautophagy in the yeast Hansenula polymorpha

    NARCIS (Netherlands)

    Leão-Helder, Adriana N; Krikken, Arjen M; Gellissen, Gerd; van der Klei, Ida J; Veenhuis, Marten; Kiel, Jan A K W

    2004-01-01

    ATG genes are required for autophagy-related processes that transport proteins/organelles destined for proteolytic degradation to the vacuole. Here, we describe the identification and characterisation of the Hansenula polymorpha ATG21 gene. Its gene product Hp-Atg21p, fused to eGFP, had a dual

  20. 78 FR 43974 - Energy and Water Use Labeling for Consumer Products Under the Energy Policy and Conservation Act...

    Science.gov (United States)

    2013-07-23

    ... FEDERAL TRADE COMMISSION 16 CFR Part 305 [3084-AB15] Energy and Water Use Labeling for Consumer Products Under the Energy Policy and Conservation Act (Energy Labeling Rule) AGENCY: Federal Trade...'') in 1979,\\1\\ pursuant to the Energy Policy and Conservation Act of 1975 (EPCA).\\2\\ The Rule requires...

  1. Structure-based drug design, synthesis and biological assays of P. falciparum Atg3-Atg8 protein-protein interaction inhibitors

    Science.gov (United States)

    Villa, Stefania; Legnani, Laura; Colombo, Diego; Gelain, Arianna; Lammi, Carmen; Bongiorno, Daniele; Ilboudo, Denise P.; McGee, Kellen E.; Bosch, Jürgen; Grazioso, Giovanni

    2018-03-01

    The proteins involved in the autophagy (Atg) pathway have recently been considered promising targets for the development of new antimalarial drugs. In particular, inhibitors of the protein-protein interaction (PPI) between Atg3 and Atg8 of Plasmodium falciparum retarded the blood- and liver-stages of parasite growth. In this paper, we used computational techniques to design a new class of peptidomimetics mimicking the Atg3 interaction motif, which were then synthesized by click-chemistry. Surface plasmon resonance has been employed to measure the ability of these compounds to inhibit the Atg3-Atg8 reciprocal protein-protein interaction. Moreover, P. falciparum growth inhibition in red blood cell cultures was evaluated as well as the cyto-toxicity of the compounds.

  2. Single-shot antithymocyte globulin (ATG) induction for pancreas/kidney transplantation: ATG-Fresenius versus Thymoglobulin.

    Science.gov (United States)

    Schulz, T; Papapostolou, G; Schenker, P; Kapischke, M

    2005-03-01

    Single-shot antithymocyte globulin (ATG) prior to reperfusion followed by tacrolimus (TAC), mycophenolate mofetil (MMF), and prednisolone (PRD) is an established induction therapy in simultaneous pancreas kidney transplant (SPK) recipients. We retrospectively analyzed 6-month data from 105 patients who received their first SPK. From January 1996 to December 2000, ATG-Fresenius was used. Since January 2001, Thymoglobulin has been administered. In the first group, 58 patients were treated with ATG-Fresenius (4-6 mg/kg body weight). In the second group, 47 patients received Thymoglobulin (1.5-2.5 mg/kg body weight). HLA-mismatch was comparable. After an observation period of 6 months, patients, kidney, and pancreas graft survival is 98.3%, 96.6%, and 93.1% in group I and 97.9%, 97.9%, and 85.1% in group II, respectively. In each group, one death with functioning graft (DWFG) was observed. Twenty (34.5%) acute rejection episodes (AR) were observed (18 patients) in group I. They were treated with steroids (n = 16) or steroids/OKT3 (n = 4). One kidney graft failure was observed due to rejection and one due to DWFG. Four pancreas grafts were lost (thrombosis, n = 2; AR, n = 1; DWFG, n = 1). In group II, 15 AR (31.9%) were seen in 12 patients and were treated with steroids (n = 12), steroids/ATG (n = 1), or steroids/OKT3 (n = 2). Seven pancreas (thrombosis, n = 5; rejection, n = 1; DWFG, n = 1) and one kidney (DWFG, n = 1) graft losses occurred. These data clearly establish that single-shot ATG prior to reperfusion, followed by TAC, MMF, and PRD results in a low incidence of AR (34.5% in group I and 31.9% in group II) after SPK. Only 6.9% (group I) and 6.4% (group II) of the patients received antibodies for rejection treatment.

  3. Problems arising in connection with the commissioning of experts in conflict-oriented implementation of nuclear law. The legal status of expert opinions in administrative procedures under the Atomic Energy Act

    International Nuclear Information System (INIS)

    Fiebig, T.H.

    1995-01-01

    Court decisions available so far do not primarily consider the problems linked to the commissioning of an expert and his mandate, as well as the legal status of the commissioning of an expert as an administrative act which might be legally contestable. Thus there are at present no court decisions that would create legal certainty in matters of the act of commissioning a nuclear expert opinion. The current legal situation is such that an independent order for commissioning of an expert opinion in compliance with section 19 III AtG (Atomic Energy Act), which in general is given in response to the refusal of the facility operator to do so, can be independently contested on the basis of section 44 a, sentence 2 VwGO (Rules of Administrative Courts). The current practice of conflict-oriented, or nuclear power phase-out-oriented, implementation of the nuclear law poses a threat to our constitutional state and to our democracy. The supply of energy as a common good is of essential importance and thus deserves fair and objective treatment free of emotions, including the matter of nuclear energy. In cases of nuclear licensing procedures meeting with impedimental treatment by a Land government favouring the nuclear power phase-out, this treatment however not fitting into the Land governments' overall political line, there is reason to call upon the Federal Government to take action for clarifying the situation. (orig./HP) [de

  4. miR-106a suppresses tumor cells death in colorectal cancer through targeting ATG7.

    Science.gov (United States)

    Hao, Haibin; Xia, Guangfeng; Wang, Chao; Zhong, Fuping; Liu, Laipeng; Zhang, Dong

    2017-06-01

    Autophagy-related gene 7 (ATG7) and miR-106a play an important role in cancer cell autophagy and apoptosis, but the outcome of ATG7 and miR-106a in colorectal cancer (CRC) still remains not clear. In this study, we found that ATG7 and miR-106a expression were mutually related with cell death and prognosis in CRC patients. In addition, we also showed that ATG7 and miR-106a expression were changeable in colorectal cancer cell lines when compared with normal cell lines, but ATG7 and miR-106a mRNA level was negatively correlated. Furthermore, ATG7 protein and mRNA levels decreased after over-expression of miR-106a, whereas the suppression of ATG7 had the opposite effect. We confirmed that miR-106a down-regulated ATG7 mRNA level by binding the specific sequence of ATG7 mRNA 3'UTR region. Moreover, the over-expression of ATG7 induced CRC cells death both in vitro and in vivo. Taken together, our study data demonstrated that ATG7 aggravated the cell death of CRC, which was inhibited by miR-106a.

  5. Overlapping Nuclear Safety Control Provisions of the Atomic Energy Act and Electric Utility Act

    International Nuclear Information System (INIS)

    Chang, Gun-Hyun; Kim, Sang-Won; Koh, Jae-Dong; Ahn, Hyung-Joon; Kim, Chang-Bum

    2007-01-01

    Before May 17, 2005, Korea's nuclear power plant (hereinafter referred to as 'NNP') regulation system was two-pronged. Every NPP system consists of primary or secondary system, and each type was respectively regulated by the Atomic Energy Act(hereinafter referred to as 'AEA') and the Electric Utility Act(hereinafter referred to as 'EUA'). This unusual regulatory regime gave rise to a number of problems with respect to operation and safety. For this reason, the Enforcement Regulation of AEA and applicable Notice were revised on May 17, 2005 to the effect that all regulation on NPPs subject to EUA was brought under the purview of AEA, except regulation on business license for nuclear power generation under Article 7 of EUA and approval of plan of works for setting up electric installations (hereinafter referred to as 'construction plan') (including approval of any changes; the same shall apply hereinafter) under Article 61 thereof. From the point of view of the Ministry of Science and Technology, the regulation of NPPs by a single law has enhanced their safety. However, the Ministry of Commerce, Industry and Energy retains regulatory authority regarding NPPs. It reviews and approves construction plans for secondary system pursuant to Article 61 of EUA and Article 28 of the Enforcement Regulation thereof. This situation arose because Article 28 of the Enforcement Regulation of EUA continues to provide for matters related with nuclear power. Therefore, continued control of NPPs under EUA ignores the relationship and respective nature of AEA and EUA. There is also possibility of violation of a superseding law. Even if said provision is not in violation of a superseding law, Article 28 of the Enforcement Regulation of EUA poses the possibility of overlapping regulation, which may violate the principle of prohibiting excessive regulation, one of the principles of the Korean Constitution. Assessment of the dual regulatory system for review of secondary system requires (i

  6. Consequences arising for research reactor operation from the planned amendment of the German atomic energy act (AtG) and atomic energy policy. Germany soon to be a third-world country in nuclear research?

    International Nuclear Information System (INIS)

    Krull, W.

    1999-01-01

    In the opinion of Dr. Wilfried Krull from Geesthacht, the Chairman of the German Research Reactor Trades Union, there is a great danger of the Federal Republic of Germany falling to the level of a third-world country as far as nuclear research is concerned. He says that it is a matter of urgency for binding exceptions from the general restrictions applicable to nuclear power stations to be incorporated into the opt-out amendment to nuclear law tabled by Juergen Trittin, the Minister for Environmental Affairs. He says that prohibition of reprocessing of spent fuel elements constitutes a violation of the surrender treaties concluded with the USA as part of non-proliferation. Furthermore, he states that a ban on reprocessing of spent nuclear fuel from research and training reactors is counterproductive. He says that there would be a particular danger if the limitation of research reactors to a rating of one megawatt, which Trittin has in the first instance planned in an initial draft law, were to be implemented in the form of a regulation. At that point, he claims, Germany would, as far as nuclear medicine (including cancer therapy) and modern technical inspection procedures (non-destructive, of materials) are concerned, become an importing country. (orig.) [de

  7. Implementing section 1332, Energy Policy Act of 1992

    International Nuclear Information System (INIS)

    Atwood, T.

    1993-01-01

    Sections 1332 Clean Coal Technology, and 1608 Environmental Technology of the Energy Policy Act of 1992 (EPACT) describe two technology Transfer Programs for creating jobs and reducing the trade deficit for the US, through providing financial assistance for projects to improve energy efficiency and reduce environmental emissions including open-quotes Greenhouse Gases.close quotes These projects are to be located in countries which are supported by the Agency for International Development (AID) or in countries with an economy in transition from a non-market to a market economy. The legislation requires a very similar approach for the two programs. Working with AID the DOE is to: (1) complete in 150 days an agreement with the appropriate US agencies for conducting the program in the host countries; (2) issue in 240 days a list of potential projects; (3) within one year issue a solicitation and (4) within 120 days after receipt of proposals make selection. In addition, the programs are to develop a procedure for providing financial assistance to projects applying for solicitations in other countries. After an initial consultation with US Treasury, Export-Import Bank, Overseas Private Investment Corp. (OPIC), and AID concerning Organization for Economic Cooperative Development rules for export credits, and the most appropriate means of financing projects under the Transfer Programs, it became apparent that, in addition to providing financing for projects through DOE programs, a more efficient, economical and prudent approach to implementing a transfer program would involve the financing of projects through organizations already experienced in the development of overseas investments. The program approach for implementation of these technology transfer programs is discussed

  8. The Putative HORMA Domain Protein Atg101 Dimerizes and Is Required for Starvation-Induced and Selective Autophagy in Drosophila

    Directory of Open Access Journals (Sweden)

    Krisztina Hegedűs

    2014-01-01

    Full Text Available The large-scale turnover of intracellular material including organelles is achieved by autophagy-mediated degradation in lysosomes. Initiation of autophagy is controlled by a protein kinase complex consisting of an Atg1-family kinase, Atg13, FIP200/Atg17, and the metazoan-specific subunit Atg101. Here we show that loss of Atg101 impairs both starvation-induced and basal autophagy in Drosophila. This leads to accumulation of protein aggregates containing the selective autophagy cargo ref(2P/p62. Mapping experiments suggest that Atg101 binds to the N-terminal HORMA domain of Atg13 and may also interact with two unstructured regions of Atg1. Another HORMA domain-containing protein, Mad2, forms a conformational homodimer. We show that Drosophila Atg101 also dimerizes, and it is predicted to fold into a HORMA domain. Atg101 interacts with ref(2P as well, similar to Atg13, Atg8a, Atg16, Atg18, Keap1, and RagC, a known regulator of Tor kinase which coordinates cell growth and autophagy. These results raise the possibility that the interactions and dimerization of the putative HORMA domain protein Atg101 play critical roles in starvation-induced autophagy and proteostasis, by promoting the formation of protein aggregate-containing autophagosomes.

  9. A study on the improvement of the legal system concerning Korean Atomic Energy Act

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Il Un; Jung, Jong Hak; Kim, Jae Ho; Moon, Jong Wook; Kim, In Sub [Chungnam National Univ., Taejon (Korea, Republic of)

    1998-03-15

    Cause-effect analysis, adjustment, and generalization of the current atomic energy act are contents of this research. These are to be based on the legal theory. Analysis of the current atomic energy act from the viewpoint of constitutional law and administrative law. Review of the other domestic legal systems which have similar problems as the atomic energy act has. Inquiry about the operation of nuclear legal systems of foreign nations.

  10. A study on the improvement of the legal system concerning Korean Atomic Energy Act

    International Nuclear Information System (INIS)

    Yoo, Il Un; Jung, Jong Hak; Kim, Jae Ho; Moon, Jong Wook; Kim, In Sub

    1998-03-01

    Cause-effect analysis, adjustment, and generalization of the current atomic energy act are contents of this research. These are to be based on the legal theory. Analysis of the current atomic energy act from the viewpoint of constitutional law and administrative law. Review of the other domestic legal systems which have similar problems as the atomic energy act has. Inquiry about the operation of nuclear legal systems of foreign nations

  11. German and European energy act. Collection of texts with accessory laws. 2. ed.

    International Nuclear Information System (INIS)

    Schwintowski, H.P.; Dannischewski, J.; Warg, F.

    2006-01-01

    The author of the book under consideration reports on the energy economy act, energy environment act, nuclear energy act as well as emission commercial law. The basis is the energy environment act from 7th July, 2005, enriched with access regulations and payment regulation in the area of electric current and gas. Furthermore, the reader of the book finds guiding principles according to price determination on the basis of direct costs. The reader also finds the main European guidelines both for electrical current and gas. The book under consideration also contains juristic texts. This book only contains the most important facts, and is written for practicians

  12. Atomic Energy Act and Related Legislation. Environmental Guidance Program Reference Book: Revision 6

    Energy Technology Data Exchange (ETDEWEB)

    1992-09-01

    This report presents information related to the Atomic Energy Act and related legislation. Sections are presented pertaining to legislative history and statutes, implementing regulations, and updates.

  13. 20 December Act No 103 amending Act No 28 of 12 May 1972 on Nuclear Energy Activities

    International Nuclear Information System (INIS)

    1985-01-01

    This Act amended the 1972 Act to take account of the ratification by Norway of the Protocols of 1982 to amend the Paris Convention on Third Party Liability in the Field of Nuclear Energy and the Brussels Supplementary Convention respectively. The amendments bring the third party liability provisions of the Act in line with the Conventions as amended by the Protocols. The modifications concern, inter alia, certain definitions, conversion of the unit of account into the Special Drawing Right (SDR) of the International Monetary Fund and increases in the amount of liability assigned at State level by a factor of approximately 2.5. (NEA) [fr

  14. Wheat homologs of yeast ATG6 function in autophagy and are implicated in powdery mildew immunity.

    Science.gov (United States)

    Yue, Jieyu; Sun, Hong; Zhang, Wei; Pei, Dan; He, Yang; Wang, Huazhong

    2015-04-01

    Autophagy-related ATG6 proteins are pleiotropic proteins functioning in autophagy and the phosphatidylinositol 3-phosphate-signaling pathways. Arabidopsis ATG6 regulates normal plant growth, pollen development and germination, and plant responses to biotic/abiotic stresses. However, the ATG6 functions in wheat (Triticum aestivum L.), an important food crop, are lacking. We identified three members, TaATG6a-6c, of the ATG6 family from common wheat. TaATG6a, 6b and 6c were localized on homeologous chromosomes 3DL, 3BL and 3AL, respectively, of the allo-hexaploid wheat genome, and evidence was provided for their essential role in autophagy. The TaATG6a-GFP fusion protein was found in punctate pre-autophagosomal structures. The expression of each TaATG6 gene restored the accumulation of autophagic bodies in atg6-mutant yeast. Additionally, TaATG6 knockdown plants showed impaired constitutive and pathogen-induced autophagy and growth abnormalities under normal conditions. We also examined the expression patterns of wheat ATG6s for clues to their physiological roles, and found that their expression was induced by the fungus Blumeria graminis f. sp. tritici (Bgt), the causal agent of powdery mildew, and by abiotic stress factors. A role for TaATG6s in wheat immunity to powdery mildew was further implied when knockdowns of TaATG6s weakly compromised the broad-spectrum powdery mildew resistance gene Pm21-triggered resistance response and, conversely and significantly, enhanced the basal resistance of susceptible plants. In addition, leaf cell death was sometimes induced by growth-retarded small Bgt mycelia on susceptible TaATG6 knockdown plants after a long period of interaction. Thus, we provide an important extension of the previous characterization of plant ATG6 genes in wheat, and observed a role for autophagy genes in wheat immune responses to fungal pathogens. Three wheat ATG6s were identified and shown to be essential for autophagy biogenesis. Wheat ATG6s are

  15. Act 25/1964 of 29 April on nuclear energy

    International Nuclear Information System (INIS)

    1964-01-01

    This outline Act governs all nuclear activities in Spain. It lays down all the principles presently applicable for safety and protection against ionizing radiation and for third party liability for nuclear damage. The Act also regulates the licensing of nuclear installations and the possession and use of radioactive materials. (NEA) [fr

  16. Outcomes of peripheral blood stem cell transplantation patients from HLA-mismatched unrelated donor with antithymocyte globulin (ATG)-Thymoglobulin versus ATG-Fresenius: a single-center study.

    Science.gov (United States)

    Huang, Wenrong; Zhao, Xiaoli; Tian, Yamin; Cao, Tingting; Li, Yanfen; Liu, Zhanxiang; Jing, Yu; Wang, Shuhong; Gao, Chunji; Yu, Li

    2015-02-01

    Although antithymocyte globulin (ATG) had been widely used in hematopoietic stem cell transplantation from unrelated donor due to its ability to prevent acute and chronic graft-versus-host disease (GVHD), the comparative efficacy and safety of ATG-Thymoglobulin (ATG-T) and ATG-Fresenius (ATG-F) in patients undergoing HLA-mismatched allogeneic peripheral blood stem cell transplantation from unrelated donors (UR-PBSCT) has not been evaluated. Retrospective analysis of patients who underwent HLA-mismatched UR-PBSCT between January 2003 and December 2013 and received pre-transplant ATG-T at a total dose of 10 mg/kg or ATG-F at a total dose of 20 mg/kg was performed. Patients who received ATG-T (n = 23) or ATG-F (n = 28) had similar baseline demographic, disease, and transplant characteristics. There were no significant between-groups differences in the probability of acute GVHD (P = 0.721) and chronic GVHD (P = 0.439). ATG-F was associated with nonsignificant trends toward higher disease-free survival at 3-year follow-up compared with ATG-T (45.7 ± 11.1 vs 61.3 ± 9.7 %, respectively, P = 0.07). A significantly greater proportion of ATG-T patients experienced high fever than ATG-F patients (P < 0.01) during ATG infusion. There was no difference in the rate of infection between the two treatment groups. There were less adverse effects comparing ATG-F with ATG-T. ATG-T at a total dose of 10 mg/kg and ATG-F at a total dose of 20 mg/kg had a similar clinical outcome in the setting of HLA-mismatched UR-PBSCT.

  17. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  18. [Knockdown of ATG5 enhances the sensitivity of human renal carcinoma cells to sunitinib].

    Science.gov (United States)

    Li, Peng; Han, Qi; Tang, Ming; Zhang, Keqin

    2017-03-01

    Objective To investigate the expression levels of autophagy-related gene 5 (ATG5) and microtubule-associated protein 1 light chain 3 (LC3) and their effects on sunitinib resistance in human renal carcinoma cells. Methods After clinic-pathologic feature and survival analysis, 99 renal clear cell carcinoma tissues with different histological grades were used to detect the expression of ATG5 and LC3 by immunohistochemistry. Renal carcinoma cell line A-498 was infected with lentivirus-mediated ATG5 shRNA. Western blot analysis was performed to confirm the efficiency of ATG5 knockdown. Proliferation rate of A-498 cells in control group and ATG5 low expression group was determined by flow cytometry. Finally, the survival rate was detected by MTT assay after A-498 cells were treated with different concentrations of sunitinib. Results The expression levels of ATG5 and LC3 in renal clear cell carcinoma tissues were significantly higher than those in para-tumor tissues. The expression levels of ATG5 and LC3 were associated with classification, histological grade, TNM stage and survival rate, rather than gender, age, location, tumor size. Compared with the control group, the protein expressions of ATG5 and LC3 significantly decreased in A-498 cells with ATG5 low expression. The cell proliferation rate in ATG5 downregulation group was lower than that in the control group. Compared with control group, the survival rate in ATG5 low expression group were significantly reduced in a dose-dependent manner after sunitinib treatment. Conclusion Autophagy is active in renal clear cell carcinoma, and the drug sensitivity to sunitinib in renal cancer cells can be enhanced by the downregulation of ATG5.

  19. 20-hydroxyecdysone upregulates Atg genes to induce autophagy in the Bombyx fat body

    Science.gov (United States)

    Tian, Ling; Ma, Li; Guo, Enen; Deng, Xiaojuan; Ma, Sanyuan; Xia, Qingyou; Cao, Yang; Li, Sheng

    2013-01-01

    Autophagy is finely regulated at multiple levels and plays crucial roles in development and disease. In the fat body of the silkworm, Bombyx mori, autophagy occurs and Atg gene expression peaks during the nonfeeding molting and pupation stages when the steroid hormone (20-hydroxyecdysone; 20E) is high. Injection of 20E into the feeding larvae upregulated Atg genes and reduced TORC1 activity resulting in autophagy induction in the fat body. Conversely, RNAi knockdown of the 20E receptor partner (USP) or targeted overexpression of a dominant negative mutant of the 20E receptor (EcRDN) in the larval fat body reduced autophagy and downregulated the Atg genes, confirming the importance of 20E-induction of Atg gene expression during pupation. Moreover, in vitro treatments of the larval fat body with 20E upregulated the Atg genes. Five Atg genes were potentially 20E primary-responsive, and a 20E response element was identified in the Atg1 (ortholog of human ULK1) promoter region. Furthermore, RNAi knockdown of 4 key genes (namely Br-C, E74, HR3 and βftz-F1) in the 20E-triggered transcriptional cascade reduced autophagy and downregulated Atg genes to different levels. Taken together, we conclude that in addition to blocking TORC1 activity for autophagosome initiation, 20E upregulates Atg genes to induce autophagy in the Bombyx fat body. PMID:23674061

  20. BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy: BECN2 CCD Structure and Interaction with ATG14

    Energy Technology Data Exchange (ETDEWEB)

    Su, Minfei; Li, Yue; Wyborny, Shane; Neau, David; Chakravarthy, Srinivas; Levine, Beth; Colbert, Christopher L.; Sinha, Sangita C. (NDSU); (IIT); (Cornell); (UTSMC)

    2017-03-12

    ATG14 binding to BECN/Beclin homologs is essential for autophagy, a critical catabolic homeostasis pathway. Here, we show that the α-helical, coiled-coil domain (CCD) of BECN2, a recently identified mammalian BECN1 paralog, forms an antiparallel, curved homodimer with seven pairs of nonideal packing interactions, while the BECN2 CCD and ATG14 CCD form a parallel, curved heterodimer stabilized by multiple, conserved polar interactions. Compared to BECN1, the BECN2 CCD forms a weaker homodimer, but binds more tightly to the ATG14 CCD. Mutation of nonideal BECN2 interface residues to more ideal pairs improves homodimer self-association and thermal stability. Unlike BECN1, all BECN2 CCD mutants bind ATG14, although more weakly than wild type. Thus, polar BECN2 CCD interface residues result in a metastable homodimer, facilitating dissociation, but enable better interactions with polar ATG14 residues stabilizing the BECN2:ATG14 heterodimer. These structure-based mechanistic differences in BECN1 and BECN2 homodimerization and heterodimerization likely dictate competitive ATG14 recruitment.

  1. The radioactive waste regulation in the new Czech Nuclear Energy Act

    International Nuclear Information System (INIS)

    Kucerka, M.

    1995-01-01

    Recently, in the Czech Republic, there is in the phase of development the Act on Peaceful Use of Nuclear Energy and Ionizing Radiation, so called the Nuclear Energy Act. This Act has to replace existing regulations and fulfill some not yet covered fields of that area. The act is developed as so called ''umbrella act'' and has to cover all aspects of the nuclear energy and ionizing radiation use, from uranium mining or isotopes use in medicine, to the power generation in nuclear power plants. It will include among others also provisions on registration and licensing, liability for nuclear damage, decommissioning and radioactive waste management funding, and some other topics, that were missing in the regulations up to today. The paper describes recent state policy in the field of radioactive waste management and the main provisions of proposed Nuclear Energy Act, concerning the radioactive waste management

  2. Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum.

    Directory of Open Access Journals (Sweden)

    Rahul Navale

    Full Text Available Conventional autophagy is a lysosome-dependent degradation process that has crucial homeostatic and regulatory functions in eukaryotic organisms. As malaria parasites must dispose a number of self and host cellular contents, we investigated if autophagy in malaria parasites is similar to the conventional autophagy. Genome wide analysis revealed a partial autophagy repertoire in Plasmodium, as homologs for only 15 of the 33 yeast autophagy proteins could be identified, including the autophagy marker Atg8. To gain insights into autophagy in malaria parasites, we investigated Plasmodium falciparum Atg8 (PfAtg8 employing techniques and conditions that are routinely used to study autophagy. Atg8 was similarly expressed and showed punctate localization throughout the parasite in both asexual and sexual stages; it was exclusively found in the pellet fraction as an integral membrane protein, which is in contrast to the yeast or mammalian Atg8 that is distributed among cytosolic and membrane fractions, and suggests for a constitutive autophagy. Starvation, the best known autophagy inducer, decreased PfAtg8 level by almost 3-fold compared to the normally growing parasites. Neither the Atg8-associated puncta nor the Atg8 expression level was significantly altered by treatment of parasites with routinely used autophagy inhibitors (cysteine (E64 and aspartic (pepstatin protease inhibitors, the kinase inhibitor 3-methyladenine, and the lysosomotropic agent chloroquine, indicating an atypical feature of autophagy. Furthermore, prolonged inhibition of the major food vacuole protease activity by E64 and pepstatin did not cause accumulation of the Atg8-associated puncta in the food vacuole, suggesting that autophagy is primarily not meant for degradative function in malaria parasites. Atg8 showed partial colocalization with the apicoplast; doxycycline treatment, which disrupts apicoplast, did not affect Atg8 localization, suggesting a role, but not exclusive, in

  3. Functional analysis of AoAtg11 in selective autophagy in the filamentous fungus Aspergillus oryzae.

    Science.gov (United States)

    Tadokoro, Takayuki; Kikuma, Takashi; Kitamoto, Katsuhiko

    2015-07-01

    Autophagy is a highly conserved cellular degradation process in eukaryotes and consists of both non-selective and selective types. Selective autophagic processes include pexophagy, mitophagy, and the cytoplasm-to-vacuole targeting (Cvt) pathway of yeast, in which particular vacuolar proteins, such as aminopeptidase I (Ape1), are selectively transported to vacuoles. Although selective autophagy has been mainly studied in the yeasts Saccharomyces cerevisiae and Pichia pastoris, there is evidence for selective autophagy in filamentous fungi; however, the details are poorly understood. In S. cerevisiae, Atg11 is a selective autophagy-specific protein that recognizes and transports substrates to the pre-autophagosomal structure (PAS). Here, we first identified an ATG11 homologue in the filamentous fungus Aspergillus oryzae and analyzed the localization of the corresponding protein, designated AoAtg11, fused to enhanced green fluorescent protein (EGFP). Imaging analysis revealed that AoAtg11-EGFP was localized to PAS-like structures. We next constructed an Aoatg11 disruptant of A. oryzae and showed that AoAtg11 is involved in pexophagy and mitophagy. In addition, AoAtg11 was found to be dispensable for non-selective autophagy and for transporting AoApe1 to vacuoles. Taken together, these results suggest that AoAtg11 is a selective autophagy-specific protein in A. oryzae, and has distinct molecular functions from that of S. cerevisiae Atg11. Copyright © 2015 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

  4. Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation.

    Science.gov (United States)

    Vuppalapati, Karuna K; Bouderlique, Thibault; Newton, Phillip T; Kaminskyy, Vitaliy O; Wehtje, Henrik; Ohlsson, Claes; Zhivotovsky, Boris; Chagin, Andrei S

    2015-12-01

    Longitudinal bone growth takes place in epiphyseal growth plates located in the ends of long bones. The growth plate consists of chondrocytes traversing from the undifferentiated (resting zone) to the terminally differentiated (hypertrophic zone) stage. Autophagy is an intracellular catabolic process of lysosome-dependent recycling of intracellular organelles and protein complexes. Autophagy is activated during nutritionally depleted or hypoxic conditions in order to facilitate cell survival. Chondrocytes in the middle of the growth plate are hypoxic and nutritionally depleted owing to the avascular nature of the growth plate. Accordingly, autophagy may facilitate their survival. To explore the role of autophagy in chondrocyte survival and constitutional bone growth, we generated mice with cartilage-specific ablation of either Atg5 (Atg5cKO) or Atg7 (Atg7cKO) by crossing Atg5 or Atg7 floxed mice with cartilage-specific collagen type 2 promoter-driven Cre. Both Atg5cKO and Atg7cKO mice showed growth retardation associated with enhanced chondrocyte cell death and decreased cell proliferation. Similarly, inhibition of autophagy by Bafilomycin A1 (Baf) or 3-methyladenine (3MA) promoted cell death in cultured slices of human growth plate tissue. To delineate the underlying mechanisms we employed ex vivo cultures of mouse metatarsal bones and RCJ3.IC5.18 rat chondrogenic cell line. Baf or 3MA impaired metatarsal bone growth associated with processing of caspase-3 and massive cell death. Similarly, treatment of RCJ3.IC5.18 chondrogenic cells by Baf also showed massive cell death and caspase-3 cleavage. This was associated with activation of caspase-9 and cytochrome C release. Altogether, our data suggest that autophagy is important for chondrocyte survival, and inhibition of this process leads to stunted growth and caspase-dependent death of chondrocytes. © 2015 American Society for Bone and Mineral Research.

  5. Electricity's "Disappearing Act": Understanding Energy Consumption and Phantom Loads

    Science.gov (United States)

    Rusk, Bryan; Mahfouz, Tarek; Jones, James

    2011-01-01

    Energy exists in many forms and can be converted from one form to another. However, this conversion is not 100% efficient, and energy is lost in the form of heat during conversion. In addition, approximately 6% of the monthly consumption of the average American household's electricity is neither lost nor used by its residents. These losses are…

  6. Structure of autophagy-related protein Atg8 from the silkworm Bombyx mori

    International Nuclear Information System (INIS)

    Hu, Chen; Zhang, Xuan; Teng, Yan-Bin; Hu, Hai-Xi; Li, Wei-Fang

    2010-01-01

    The crystal structure of autophagy-related protein Atg8 from the silkworm B. mori has two additional helices at the N-terminus before the expected ubiquitin fold. Autophagy-related protein Atg8 is ubiquitous in all eukaryotes. It is involved in the Atg8–PE ubiquitin-like conjugation system, which is essential for autophagosome formation. The structures of Atg8 from different species are very similar and share a ubiquitin-fold domain at the C-terminus. In the 2.40 Å crystal structure of Atg8 from the silkworm Bombyx mori reported here, the ubiquitin fold at the C-terminus is preceded by two additional helices at the N-terminus

  7. Recovery Act. Development of a Model Energy Conservation Training Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-07-05

    The overall objective of this project was to develop an updated model Energy Conservation training program for stationary engineers. This revision to the IUOE National Training Fund’s existing Energy Conservation training curriculum is designed to enable stationary engineers to incorporate essential energy management into routine building operation and maintenance tasks. The curriculum uses a blended learning approach that includes classroom, hands-on, computer simulation and web-based training in addition to a portfolio requirement for a workplace-based learning application. The Energy Conservation training program goal is development of a workforce that can maintain new and existing commercial buildings at optimum energy performance levels. The grant start date was July 6, 2010 and the project continued through September 30, 2012, including a three month non-funded extension.

  8. Identification of breast cancer cell subtypes sensitive to ATG4B inhibition.

    Science.gov (United States)

    Bortnik, Svetlana; Choutka, Courtney; Horlings, Hugo M; Leung, Samuel; Baker, Jennifer H; Lebovitz, Chandra; Dragowska, Wieslawa H; Go, Nancy E; Bally, Marcel B; Minchinton, Andrew I; Gelmon, Karen A; Gorski, Sharon M

    2016-10-11

    Autophagy, a lysosome-mediated degradation and recycling process, functions in advanced malignancies to promote cancer cell survival and contribute to cancer progression and drug resistance. While various autophagy inhibition strategies are under investigation for cancer treatment, corresponding patient selection criteria for these autophagy inhibitors need to be developed. Due to its central roles in the autophagy process, the cysteine protease ATG4B is one of the autophagy proteins being pursued as a potential therapeutic target. In this study, we investigated the expression of ATG4B in breast cancer, a heterogeneous disease comprised of several molecular subtypes. We examined a panel of breast cancer cell lines, xenograft tumors, and breast cancer patient specimens for the protein expression of ATG4B, and found a positive association between HER2 and ATG4B protein expression. We showed that HER2-positive cells, but not HER2-negative breast cancer cells, require ATG4B to survive under stress. In HER2-positive cells, cytoprotective autophagy was dependent on ATG4B under both starvation and HER2 inhibition conditions. Combined knockdown of ATG4B and HER2 by siRNA resulted in a significant decrease in cell viability, and the combination of ATG4B knockdown with trastuzumab resulted in a greater reduction in cell viability compared to trastuzumab treatment alone, in both trastuzumab-sensitive and -resistant HER2 overexpressing breast cancer cells. Together these results demonstrate a novel association of ATG4B positive expression with HER2 positive breast cancers and indicate that this subtype is suitable for emerging ATG4B inhibition strategies.

  9. Molecular cloning, characterization and expression analysis of ATG1 in the silkworm, Bombyx mori.

    Science.gov (United States)

    Casati, Barbara; Terova, Genciana; Cattaneo, Anna Giulia; Rimoldi, Simona; Franzetti, Eleonora; de Eguileor, Magda; Tettamanti, Gianluca

    2012-12-15

    Atg1 is a Serine/Threonine protein kinase that plays a pivotal role in autophagy. A complete coding sequence of ATG1 is not available for the silkworm, Bombyx mori which is a good model for studying the autophagic process. In the present study we isolated two full-length cDNAs of 2175 (transcript variant A) and 2271 (transcript variant B) bases representing ATG1 in the silkworm. Phylogenetic analysis indicated that BmATG1 was closely related to orthologs of other insects. The encoded BmAtg1 proteins shared extensive homology with orthologs from yeast to mammals, showing high conservation at the N-terminal region where the catalytic domain and ATP- and Mg-binding sites are located. A de novo prediction of the three-dimensional structure for each protein is presented. We used real-time RT-PCR to quantify dynamic changes in mRNA copy number of BmATG1 in the midgut and fat body of fifth instar larvae undergoing starvation, as well as in other tissues of silkworm at the end of last larval instar. Our qPCR results revealed that BmATG1 expression levels at the end of larval life were comparable in the midgut, fat body and Malpighian tubules, while these were higher in the gonads; moreover, the mRNA copy number of ATG1 was very different among the anterior, middle and posterior silk glands. Real-time PCR analysis also showed that starvation significantly influenced BmATG1 mRNA copy number in the fat body of silkworm, inducing an upregulation 24h after food withdrawal, with only a slight effect in the midgut. Low expression levels of BmATG1 were observed in both tissues of control animals up to the second day of spinning phase. Copyright © 2012 Elsevier B.V. All rights reserved.

  10. P.L. 110-140, "Energy Independence and Security Act of 2007", 2007

    Energy Technology Data Exchange (ETDEWEB)

    None

    2007-12-19

    The Energy Independence and Security Act of 2007 (EISA), signed into law on December 19, 2007, set forth an agenda for improving U.S. energy security across the entire economy. While industrial energy efficiency is specifically called out in Title IV, Subtitle D, other EISA provisions also apply to AMO activities.

  11. Yugoslavia: Act of 21 November 1984 on radiation protection and the safe use of nuclear energy

    International Nuclear Information System (INIS)

    1985-01-01

    This Act which entered into force on 1 December 1984 repeals the 1976 Act on Protection against Ionizing Radiation and regulates most of the peaceful uses of nuclear energy and radiation protection in Yugoslavia. The Act lays down the licensing procedure for nuclear installations and covers safety-related questions in connection with standards, technical criteria etc. It also takes into account several areas regulated at international level, namely safeguards and physical protection of nuclear material. (NEA) [fr

  12. Balancing act: Government roles in an energy conservation network

    NARCIS (Netherlands)

    Peterman, A.; Kourula, A.; Levitt, R.

    2014-01-01

    Government-led interorganizational alliance networks present a sensible opportunity to overcome many societal challenges through collaborative governance. In particular, few researchers have studied alliance networks in the field of energy conservation in commercial buildings—a sector with unique

  13. Endangered Species Act and energy facility planning: compliance and conflict

    Energy Technology Data Exchange (ETDEWEB)

    Shreeve, D; Calef, C; Nagy, J

    1978-05-01

    New energy facilities such as coal mines, gasification plants, refineries, and power plants--because of their severe environmental impacts--may, if sited haphazardly, jeopardize endangered species. By law, conflicts between energy-facility siting and endangered species occurrence must be minimized. To assess the likelihood of such conflicts arising, the authors used data from the Fish and Wildlife Service, Endangered Species Office, that describe the species' ranges by county. This data set was matched with county-level occurrences of imminent energy developments to find counties of overlap and hence potential conflict. An index was developed to measure the likelihood of actual conflict occurring in such counties. Factors determining the index are: numbers of endangered species inhabiting the county, number of energy-related developments, and to what degree the county remains in a wild or undeveloped state. Maps were prepared showing (1) geographic ranges of endangered species by taxonomic groups (mammals, fish, etc.) and (2) counties of conflict.

  14. Handbook of technology law. General funamentals, environment law, genetic engineering act, energy act, telecommunication act and media act, patent act, computer act. 2. ed.; Handbuch des Technikrechts. Allgemeine Grundlagen Umweltrecht, Gentechnikrecht, Energierecht, Telekommunikations- und Medienrecht, Patentrecht, Computerrecht

    Energy Technology Data Exchange (ETDEWEB)

    Schulte, Martin; Schroeder, Rainer (eds.) [Technische Univ. Dresden (Germany). Juristische Fakultaet

    2011-07-01

    On the boundaries between technology sciences, jurisprudence, social sciences and economic science the technology law proves as a cross-sectional area par excellence. The bases of the technology law are presented: individual, particularly important scopes of the technology law (appliance safety regulations, technology law and environment law, genetic engineering act, energy right, telecommunications law and media law, patent law, computer law, data security, legally binding telecooperation) are analyzed in detail. The manual contacts all lawyers who want to provide a first in-depth insight of this new field of law. [German] Im Grenzbereich von Technik-, Rechts-, Sozial- und Wirtschaftswissenschaften erweist sich das Technikrecht als Querschnittsmaterie par excellence. Die Grundlagen des Technikrechts werden dargestellt; einzelne, besonders wichtige Bereiche des Technikrechts (Geraetesicherheitsrecht, Technik und Umweltrecht, Gentechnikrecht, Energierecht, Telekommunikations- und Medienrecht, Patentrecht, Computerrecht, Datensicherheit, Rechtsverbindliche Telekooperation) werden eingehend analysiert. Das Handbuch wendet sich an alle in Wissenschaft und Praxis mit dem Technikrecht befassten Juristen, die sich einen ersten vertieften Einblick in dieses neue Rechtsgebiet verschaffen wollen. (orig.)

  15. Regulatory aspect of radiation usage : Atomic Energy Licensing Act, 1984 (ACT 304): summary

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    Explaning in general the matters must be obeyed by every `person` who exercise the activities related to atomic energy in Malaysia . Details explanation provided in the regulations and orders. Regulations and orders are supported by other documents - code of practice, standards, advice materials.

  16. Regulatory aspect of radiation usage : Atomic Energy Licensing Act, 1984 (ACT 304): summary

    International Nuclear Information System (INIS)

    1993-01-01

    Explaning in general the matters must be obeyed by every 'person' who exercise the activities related to atomic energy in Malaysia . Details explanation provided in the regulations and orders. Regulations and orders are supported by other documents - code of practice, standards, advice materials

  17. ALKEM: Public hearing held in accordance with the Atomic Energy Act on September 24, 1984

    International Nuclear Information System (INIS)

    1984-01-01

    The report presents the verbatim record of the public hearing organised in accordance with section 13 Atomic Energy Act, on the issue of a licence applied for for constructing and operating an ALKEM nuclear fuel fabrication plant, and extending the plutonium storage capacity from 460 kg of Pu to 6.7 tonnes of Pu, in compliance with section 7 Atomic Energy Act and section 4 BImSchG (air pollution abatement). (orig./HP) [de

  18. Bulgaria: act on the safe use of nuclear energy (as last amended on 29 december 2002)

    International Nuclear Information System (INIS)

    2003-01-01

    This issue concerns the act on the Safe use of nuclear energy (as last amended on 29 december 2002) in Bulgaria. This act covers the activities associated with the State regulation of the Safe use of nuclear energy and ionizing radiations and with the safety of radioactive waste management and spent fuel management. it specifies the rights and duties of licenses in conducting those activities, to ensure nuclear safety and radiation protection. (N.C.)

  19. Federal Act on the peaceful uses of atomic energy and protection against radiation

    International Nuclear Information System (INIS)

    1959-12-01

    This is a framework Act regulating the peaceful uses of atomic energy in Switzerland. It establishes a licensing and control system for the construction and operation of nuclear installations, transport and possession of nuclear substances as well as for other nuclear activities. The Act also defines the measures for protection against ionizing radiation and contains a series of provisions sanctioning any actions jeopardising nuclear safety or violating the Act itself. Chapter 4 (Sec. 12-18) dealing with nuclear third party liability is repealed and replaced by the Act of 1979 on nuclear third party liability. (NEA) [fr

  20. Act No. 1860 of 31 December 1962 on the peaceful uses of nuclear energy

    International Nuclear Information System (INIS)

    1963-01-01

    This Act is the first text which regulates in Italy the peaceful uses for nuclear energy. It concerns the industrial and scientific uses of the atom; plants for the preparation, manufacture, separation, treatment, etc. of nuclear substances and lays down general provisions for the different activities connected with the peaceful uses of nuclear energy. Following the establishment of the CNEN, this Act provides an essential framework for the development of national nuclear activities, also in connection with the regulations already provided by the Euratom Treaty ratified by Italy by Act No. 1203 of 14 October 1957. (NEA) [fr

  1. The Energy transition for green growth. Energy transition for green growth act in action: Regions - Citizens - Business

    International Nuclear Information System (INIS)

    2016-07-01

    A great ambition underlies France's Energy Transition for Green Growth Act: to make France - following on from the Paris Climate Summit - an exemplary nation in terms of reducing its greenhouse gas emissions, diversifying its energy model and increasing the deployment of renewable energy sources. This Act provides a unique opportunity both for climate negotiations and for France. It sets goals and implements operational solutions which can be shared with different regions, companies, researchers, the public and anyone with a long-standing commitment to fighting climate change. The Energy Transition for Green Growth Act and its attendant action plans are designed to give France the means to make a more effective contribution to tackling climate change and reinforce its energy independence, while striking a better balance in its energy mix and creating jobs and business growth. The texts required for its implementation are operational and support plans are in place. These tools are available to private individuals, businesses and the regions, enabling them to take concrete action. This document summarizes the actions under way: Defining common objectives, Acting together, Renovating buildings, developing clean transport, Tackling waste and promoting the circular economy, Promoting renewable energy, optimising nuclear safety and public information, Simplifying and clarifying procedures

  2. Blue Line Innovations brochure : Think green, act smart, save energy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    Blue Line Innovations Inc. is working with leading electric utilities and regulatory agencies to provide smart-home technologies to consumers for demand-side management. Their latest product is the PowerCost Monitor, a real-time feedback product that help households understand and reduce the amount of electricity they use. The monitor, which reveals electricity use in real-time by both total and current cost and kilowatt hour, uses wireless encrypted technology to send usage information from an outside meter to an in-home display. The small detector/transmitter can be easily installed to an existing household electro-mechanical utility meter by the homeowner without an electrician or service disruption. Studies have shown that when domestic users are provided with real-time feedback on electricity usage, they can reduce their energy bills by as much as 20 per cent. This in-home measuring and reporting unit helps customers make decisions about changing their usage habits, purchasing electricity-saving light and appliances and conserving energy. In a demonstration project, Hydro-One installed PowerCost Monitors in the homes of Hydro One customers in Ontario in July 2004. The objective was to determine the extent of changes in customer behaviour and reductions in electricity consumption resulting from direct real-time feedback information on electricity consumption. Other demonstration projects have been launched in conjunction with CEA Technologies Inc., Natural Resources Canada, Newfoundland Power and BC hydro to install the monitors in homes on both coasts of Canada. Governments, utilities, communities and individuals are recognizing that saving energy is a critical factor to sustainable development by conserving natural resources and reducing pollution. A list of suggestions for reducing electricity use in lighting, kitchens, laundry and heating and cooling were also presented. 1 fig.

  3. P.L. 110-140, "Energy Independence and Security Act of 2007" (2007)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2007-12-13

    An act to move the United States toward greater energy independence and security, to increase the production of clean renewable fuels, to protect consumers, to increase the efficiency of products, buildings, and vehicles, to promote research on and deploy greenhouse gas capture and storage options, and to improve the energy performance of the Federal Government, and for other purposes.

  4. No 12 of 1971, Nuclear Energy (An Bord Fuinnimh Nuicleigh) Act, 1971

    International Nuclear Information System (INIS)

    1971-07-01

    This Act sets up a Nuclear Energy Board and provides for its duties and composition. The Board advises the Government on nuclear energy matters, prepares safety codes and regulations on fissile or other radioactive substances and irradiating apparatus. It is the licensing authority for activities involving ionizing radiation [fr

  5. MicroRNA-20a inhibits autophagic process by targeting ATG7 and ATG16L1 and favors mycobacterial survival in macrophage cells.

    Directory of Open Access Journals (Sweden)

    Le Guo

    2016-10-01

    Full Text Available Autophagy plays important roles in the host immune response against mycobacterial infection. Mycobacterium tuberculosis (M. tuberculosis can live in macrophages owing to its ability to evade attacks by regulating autophagic response. MicroRNAs (miRNAs are small noncoding, endogenously encoded RNA which plays critical roles in precise regulation of macrophage functions. Whether miRNAs specifically influence the activation of macrophage autophagy during M. tuberculosis infection are largely unknown. In this study, we demonstrate that BCG infection of macrophages resulted in enhanced expression of miRNA-20a, which inhibits autophagic process by targeting ATG7 and ATG16L1 and promotes BCG survival in macrophages. Forced overexpression of miR-20a decreased the expression levels of LC3-II and the number of LC3 puncta in macrophages, and promoted BCG survival in macrophages, while transfection with miR-20a inhibitor had the opposite effect. Moreover, the inhibitory effect of miR-20a on autophagy was further confimed by transmission electron microscopy (TEM analysis. Quantification of autophagosomes per cellular cross-section revealed a significant reduction upon transfection with miR-20a mimic, but transfection with miR-20a inhibitor increased the number of autophagosomes per cellular cross-section. Moreover, silencing of ATG7 significantly inhibited autophagic response, and transfection with ATG7 siRNA plus miR-20a mimic could further decrease autophagic response. Collectively, our data reveal that miR-20a inhibits autophagic response and promotes BCG survival in macrophages by targeting ATG7 and ATG16L1, which may have implications for a better understanding of pathogenesis of M. tuberculosis infection.

  6. microRNA-20a Inhibits Autophagic Process by Targeting ATG7 and ATG16L1 and Favors Mycobacterial Survival in Macrophage Cells.

    Science.gov (United States)

    Guo, Le; Zhao, Jin; Qu, Yuliang; Yin, Runting; Gao, Qian; Ding, Shuqin; Zhang, Ying; Wei, Jun; Xu, Guangxian

    2016-01-01

    Autophagy plays important roles in the host immune response against mycobacterial infection. Mycobacterium tuberculosis ( M. tuberculosis ) can live in macrophages owing to its ability to evade attacks by regulating autophagic response. MicroRNAs (miRNAs) are small noncoding, endogenously encoded RNA which plays critical roles in precise regulation of macrophage functions. Whether miRNAs specifically influence the activation of macrophage autophagy during M. tuberculosis infection are largely unknown. In this study, we demonstrate that BCG infection of macrophages resulted in enhanced expression of miRNA-20a, which inhibits autophagic process by targeting ATG7 and ATG16L1 and promotes BCG survival in macrophages. Forced overexpression of miR-20a decreased the expression levels of LC3-II and the number of LC3 puncta in macrophages, and promoted BCG survival in macrophages, while transfection with miR-20a inhibitor had the opposite effect. Moreover, the inhibitory effect of miR-20a on autophagy was further confirmed by transmission electron microscopy (TEM) analysis. Quantification of autophagosomes per cellular cross-section revealed a significant reduction upon transfection with miR-20a mimic, but transfection with miR-20a inhibitor increased the number of autophagosomes per cellular cross-section. Moreover, silencing of ATG7 significantly inhibited autophagic response, and transfection with ATG7 siRNA plus miR-20a mimic could further decrease autophagic response. Collectively, our data reveal that miR-20a inhibits autophagic response and promotes BCG survival in macrophages by targeting ATG7 and ATG16L1, which may have implications for a better understanding of pathogenesis of M. tuberculosis infection.

  7. 75 FR 44163 - Implementation of Regulations Required Under Title XI of the Food, Conservation and Energy Act of...

    Science.gov (United States)

    2010-07-28

    ... Under Title XI of the Food, Conservation and Energy Act of 2008; Conduct in Violation of the Act AGENCY... Act and provide for a fairer market place. DATES: We will consider comments we receive by November 22... clarify conditions for industry compliance with the P&S Act and provide for a fairer market place. We have...

  8. Topical problems connected with the German act on electricity from renewable energy sources (StrEG)

    International Nuclear Information System (INIS)

    Pohlmann, M.

    1998-01-01

    The German act (StrEG) intended to enhance the use of renewable energy sources for electricity generation and to promote the relevant technologies raises some problems in connection with constitutional law that still await judicial review by the German Federal Constitutional Court. In addition, doubts as to the lawfulness of provisions of the act have been emerging in connection with EC laws governing the regime of subsidies and state aid. The article here summarizes the current situation. (orig./CB) [de

  9. 75 FR 35338 - Implementation of Regulations Required Under Title XI of the Food, Conservation and Energy Act of...

    Science.gov (United States)

    2010-06-22

    ... Under Title XI of the Food, Conservation and Energy Act of 2008; Conduct in Violation of the Act AGENCY... fairer market place. DATES: We will consider comments we receive by August 23, 2010. ADDRESSES: We invite... Title XI of the Food, Conservation and Energy Act of 2008 (Farm Bill) (Pub. L. 110-246), Congress...

  10. Building a Sustainable Energy Future for Africa - Acting Now and Together

    Energy Technology Data Exchange (ETDEWEB)

    Fall, L.

    2007-07-01

    The key energy challenges Africa is facing are: low level of access to commercial energy, low per capita energy consumption, weak development of energy infrastructure and lack of investment and financing for energy projects. Addressing these challenges is critical for sustainable economic and social development, and assured access to secure, affordable and reliable energy. In spite of these daunting challenges, Africa is well endowed in energy resources, but these resources are largely untapped and concentrated in a few countries. In addition, there are numerous 'rooms' for opportunities that could be seized concretely to overcome the main obstacles to the Sustainable Energy Development of the Continent. Thus, right actions must be taken to overcome these obstacles, including: financing the huge needed investments, technological development, private-public partnerships, energy market reform and effective regulation, sound and sustainable energy policies, and economic and social measures. Subsequently, from priority areas, the related stakeholders should 'act now' and 'act together', through effective collaboration and partnership and making proper alliances, to initiate effective and concrete actions to support Africa aspirations in order to build a Sustainable Energy Future for Africa, in a cost-effective and timely manner. (auth)

  11. Audit Report on "The Department of Energy's American Recovery and Reinvestment Act -- Florida State Energy Program"

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-06-01

    The Department of Energy's Office of Energy Efficiency and Renewable Energy (EERE) provides grants to states, territories, and the District of Columbia to support their energy priorities through the State Energy Program (SEP). The SEP provides Federal financial assistance to carry out energy efficiency and renewable energy projects that meet each state's unique energy needs while also addressing national goals such as energy security. Federal funding is based on a grant formula that takes into account population and energy consumption. The SEP emphasizes the state's role as the decision maker and administrator for the program. The American Recovery and Reinvestment Act of 2009 (Recovery Act) expanded the SEP, authorizing $3.1 billion in grants. Based on existing grant formulas and after reviewing state-level plans, EERE made awards to states. The State of Florida's Energy Office (Florida) was allocated $126 million - a 90-fold increase over Florida's average annual SEP grant of $1.4 million. Per the Recovery Act, this funding must be obligated by September 30, 2010, and spent by April 30, 2012. As of March 10, 2010, Florida had expended $13.2 million of the SEP Recovery Act funds. Florida planned to use its grant funds to undertake activities that would preserve and create jobs; save energy; increase renewable energy sources; and, reduce greenhouse gas emissions. To accomplish Recovery Act objectives, states could either fund new or expand existing projects. As a condition of the awards, EERE required states to develop and implement sound internal controls over the use of Recovery Act funds. Based on the significant increase in funding from the Recovery Act, we initiated this review to determine whether Florida had internal controls in place to provide assurance that the goals of the SEP and Recovery Act will be met and accomplished efficiently and effectively. We identified weaknesses in the implementation of SEP Recovery Act projects that

  12. Special Report "The American Recovery and Reinvestment Act and the Department of Energy"

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-03-01

    The American Recovery and Reinvestment Act of 2009 (Recovery Act) was signed into law on February 17, 2009, as a way to jumpstart the U.S. economy, create or save millions of jobs, spur technological advances in science and health, and invest in the Nation's energy future. This national effort will require an unprecedented level of transparency and accountability to ensure that U.S. citizens know where their tax dollars are going and how they are being spent. As part of the Recovery Act, the Department of Energy will receive more than $38 billion to support a number of science, energy, and environmental initiatives. Additionally, the Department's authority to make or guarantee energy-related loans has increased to about $127 billion. The Department plans to disburse the vast majority of the funds it receives through grants, cooperative agreements, contracts, and other financial instruments. The supplemental funding provided to the Department of Energy under the Recovery Act dwarfs the Department's annual budget of about $27 billion. The infusion of these funds and the corresponding increase in effort required to ensure that they are properly controlled and disbursed in a timely manner will, without doubt, strain existing resources. It will also have an equally challenging impact on the inherent risks associated with operating the Department's sizable portfolio of missions and activities and, this is complicated by the fact that, in many respects, the Recovery Act requirements represent a fundamental transformation of the Department's mission. If these challenges are to be met successfully, all levels of the Department's structure and its many constituents, including the existing contractor community; the national laboratory system; state and local governments; community action groups and literally thousands of other contract, grant, loan and cooperative agreement recipients throughout the Nation will have to strengthen existing or

  13. Act 25/1968 of 20 June amending Sections 9 and 16 of Act 25/1964 of 29 April on nuclear energy

    International Nuclear Information System (INIS)

    1968-01-01

    The main purpose of this Act to amend the 1964 Act on Nuclear Energy is to set the age limit for the Board of the Junta de Energia Nuclear at 70; that of the Director is set at 65. These same provisions also apply to the Chairman and the Director of the Institute for Nuclear Studies. Finally, the Act modifies the composition of the Board of the Junta which henceforth includes only one Vice-Chairman. (NEA) [fr

  14. Energy Policy Act transportation rate study: Availability of data and studies

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-13

    Pursuant to Section 1340(c) of the Energy Policy Act of 1992 (EPACT), this report presents the Secretary of Energy`s review of data collected by the Federal Government on rates for rail and pipeline transportation of domestic coal, oil, and gas for the years 1988 through 1997, and proposals to develop an adequate data base for each of the fuels, based on the data availability review. This report also presents the Energy Information Administration`s findings regarding the extent to which any Federal agency is studying the impacts of the Clean Air Act Amendments of 1990 (CAAA90) and other Federal policies on the transportation rates and distribution patterns of domestic coal, oil, and gas.

  15. German support systems for onshore wind farms in the context of Polish acts limiting wind energy development

    Directory of Open Access Journals (Sweden)

    Dawid Leszek

    2017-09-01

    Full Text Available European energy system is undergoing a deep transition to low-emission energy sources, mainly wind farms. This transition is caused mostly by energy politics of European Union (EU and its goals in the topic of renewable energy. European wind energy is dominated by Germany that produces half of total wind energy in EU. The aim of this article is to present support systems for wind farms existing in Germany in the context of introducing in Poland the Act of 20 May 2016 on Wind Energy Investments limiting onshore wind farms localization and Act of 22 June 2016 introducing changes to the Act on Renewable Energy Sources (RES and some other acts. It is postulated to make amendments of acts regulating RES while considering German solutions.

  16. Licensing of nuclear facilities according to the Bulgarian Act on the Safe Use of Nuclear Energy

    International Nuclear Information System (INIS)

    Stoyanova-Todorova, P.

    2004-01-01

    The new Bulgarian Act on the Safe Use of Nuclear Energy /Nuclear Act/ has replaced the former Act on the Use of Nuclear Energy for Peaceful Purposes. The new Nuclear Act covers the activities involving nuclear energy and sources of ionising radiation mainly by establishing a consistent licensing regime. About 13 regulations specifying the provisions of the Nuclear Act have been recently adopted by the Council of Ministers, the most important one being the Regulation on the Procedure for Issue of Licenses and Permits for the Safe Use of Nuclear Energy. The Chairman of the Nuclear Regulatory Agency (NRA) is authorised by the law to consider any application for issue of a license or a permit under the Bulgarian Nuclear Act. The procedure starts with an application, filed with the NRA, and continues about nine months. The final decision could be for issuing of the license or permit or a refusal for issuing the claimed document. The denial must be grounded and is subject to appeal. The Nuclear Act prescribes the conditions for issuing of two types of licensing documents (authorisations): licenses and permits. From a legal point of view the two types of licensing documents have one and the same nature - they are individual administrative acts according to the Bulgarian law. That is why there is no difference between them in terms of the issuing procedure. The difference between licenses and permits could be explained as follows: while a license is issued for reiterated activities, a permit is issued for non-reoccurring activities, this division being a specific feature of the Bulgarian Nuclear Act. In the field of nuclear facilities usage only one type of license is provided for by the Nuclear Act - a license for operation of a nuclear facility unit. For the rest of the activities issuing of permits is envisaged, those permits being in compliance with the main stages of the authorisation process formulated by the IAEA, following the step-by-step approach - siting, design

  17. Third-party protection and residual risk in Atomic Energy Act. On legally dogmatic classification of paragraph 7 Atomic Energy Act in the jurisprudence of the Federal Constitutional Law and Federal Administrative Court

    International Nuclear Information System (INIS)

    Arndt, Hans-Wolfgang

    2012-01-01

    On 25th June 2009, the Council of the European Union has passed the directive 2009/71/EURATOM on a common framework for nuclear safety of nuclear installations. At first, the 12th Law amending the Atomic Energy Act supplements the Atomic Energy Act by regulations which implement the directive 2009/71/EURATIM into national law. In addition, paragraph 7 Atomic Energy Act introduces a new substantive obligation of the operators of nuclear power plants. The author of the contribution reports on whether paragraph 7 Atomic Energy Act provides additional nuclear protection or reduces the potential protection by law and jurisprudence.

  18. Impacts of the Federal Energy Acts and Other Influences on Prices of Agricultural Commodities and Food

    OpenAIRE

    Ferris, John N.

    2013-01-01

    Most of the increase in ethanol production in the 2008-2012 period can be attributed to the Energy Independence and Security Act of 2007 (EISA) and earlier federal energy legislation. The expansion in U.S. biofuel production, particularly ethanol, was the predominant cause of the elevated commodity prices. Other influences documented were a weak dollar, speculation and an increasingly inelastic commodity demand function. The supply function displayed more elasticity as crop farmers responded ...

  19. Planned amendment to the Atomic Energy Act in the area of waste management

    International Nuclear Information System (INIS)

    Wild, E.

    1991-01-01

    In view of the present lack of agreement on nuclear energy utilization the lecturer would rather abide by the present legal status of the Atomic Energy Act and thus prefer no amendment. However he considers a jurisprudential discussion expedient and debates the main points of the Rengeling expertise from his point of view: privatization, licensing competence, plan approval, proof of having made provisions for waste disposal, European cooperation, direct ultimate waste disposal, financing. (HSCH) [de

  20. Energy Independence and Security Act of 2007: A Summary of Major Provisions

    Science.gov (United States)

    2007-12-21

    costs of the program. Section 548 stresses that funding will supplement, not replace, funding provided by DOE under the Weatherization and State Energy... telecommuting programs. Reports to Congress are required for each of those programs. Section 1204 raises the Small Business Investment Act (SBIA

  1. P.L. 94-163, "Energy Policy and Conservation Act" (EPCA) (1975)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-12-13

    Energy Policy and Conservation Act. Bill Summary & Status 94th Congress. Issue orders prohibiting power plants and major fuel burning installations from using natural gas or petroleum products as fuel if they had been capable on June 22, 1974, of burning coal.

  2. The intended purpose of the draft amendment of the Atomic Energy Act

    International Nuclear Information System (INIS)

    Preuss, U.K.

    1994-01-01

    The seventh amendments to the Atomic Energy Act may become the most sweeping and significant reform the German atomic energy laws have undergone: the suggested amendment will transform the character of the Atomic Energy Act from its present nature of a nuclear licensing system into a technology management and control instrument. The function of the Atomic Energy Act so far is to deal with the consequences of an established technology and its known, ambivalent effects: aspects such as waste management and the technical and economic consequences implied n the decommissioning of nuclear installations play a far bigger role than planning, construction and operation of new installations. It is only consequent in this respect to abolish the 'promotional purpose' of the Act. This will mean, however, that the Federal Government relinquishes its responsibility for development and management of nuclear technology, handling it over to the private plant owners and operators. The responsibility that will remain with the Federal Government in connection with nuclear technology is linked with the Government's duty to provide for protection of the citizens. (HP) [de

  3. Wave loadings acting on innovative rubble mound breakwater for overtopping wave energy conversion

    DEFF Research Database (Denmark)

    Contestabile, Pasquale; Iuppa, Claudio; Lauro, Enrico Di

    2017-01-01

    Highlights •An innovative breakwater for overtopping wave energy conversion has been studied. •Physical model tests have been carried out and analysed. •Breakwater design information on loadings acting on various parts of the structure has been presented. •Design formulae and validation of some t...

  4. Why the Energy Policy Act Is a Foundation for the Future

    Energy Technology Data Exchange (ETDEWEB)

    Kuhn, Thomas R.

    2005-12-01

    The Energy Policy Act of 2005 was a long time in the making. Given its scope, the very fact that it has become law is remarkable. But the devil is in the details, and there are many details to be worked out in the months and years ahead.

  5. Why the Energy Policy Act Is a Foundation for the Future

    Energy Technology Data Exchange (ETDEWEB)

    Thomas R. Kuhn

    2005-12-15

    The Energy Policy Act of 2005 was a long time in the making. Given its scope, the very fact that it has become law is remarkable. But the devil is in the details, and there are many details to be worked out in the months and years ahead.

  6. In vitro effects of ATG-Fresenius on immune cell adhesion.

    Science.gov (United States)

    Kanzler, I; Seitz-Merwald, I; Schleger, S; Kaczmarek, I; Kur, F; Beiras-Fernandez, A

    2013-06-01

    ATG-Fresenius, a purified rabbit polyclonal anti-human T-lymphocyte immunoglobulin is used for induction immunosuppression as well as prevention and treatment of acute rejection episodes among patients receiving solid organ transplants. The aim of this study was to investigate the in vitro activity of ATG-Fresenius upon immune cell adhesion, which may explain its activity to mitigate ischemia-reperfusion injury. Human vascular endothelial cells (HUVEC) and peripheral blood mononuclear cells (PBMCs) isolated from umbilical vein or peripheral blood were incubated 20 to 24 hours before analysis. HUVEC were incubated with 10 and 100 μg/mL ATG-Fresenius or reference polyclonal rabbit immunoglobulin G. Analysis of immune cell adhesion to endothelial cells was studied in cocultures of PBMCs and adherent HUVEC. Endothelial cell expression of adhesion molecules CD62E and CD54 was determined by flow cytometry. The numbers of T-, B- and natural killer cells attached to HUVEC were also determined by flow cytometry. Groups were compared using one-way analysis of variance. We showed that ATG-Fresenius binds to endothelial cells particularly activated ones expressing increased levels of E-selectin and ICAM-1. The increased binding of ATG-Fresenius to activated endothelial cells was consistent with its known binding to Intercellular Adhesion Molecule 1 (ICAM-1) and selectins. We also showed that ATG-Fresenius inhibited adhesion of prestimulated immune cells to activated endothelium. We demonstrated dose-dependent binding of ATG-Fresenius to activated endothelial cells. Copyright © 2013 Elsevier Inc. All rights reserved.

  7. Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis.

    Science.gov (United States)

    Bouderlique, Thibault; Vuppalapati, Karuna K; Newton, Phillip T; Li, Lei; Barenius, Björn; Chagin, Andrei S

    2016-03-01

    It has been suggested that the lysosomal recycling process called macro-autophagy plays a role in osteoarthritis development. We thus decided to genetically ablate the autophagy-indispensable Atg5 gene specifically in chondrocytes and analyse the development of osteoarthritis upon aging and in a post-traumatic model. Mice lacking the Atg5 gene in their chondrocytes (Atg5cKO) were generated by crossing Atg5-floxed mice with transgenic mice that expressed cre recombinase driven by the collagen type 2 promoter. Animals were analysed at the age of 2, 6 and 12 months for age-related osteoarthritis or underwent mini-open partial medial meniscectomy at 2 months of age and were analysed 1 or 2 months after surgery. We evaluated osteoarthritis using the Osteoarthritis Research Society International (OARSI) scoring on safranin-O-stained samples. Cell death was evaluated by terminal deoxy-nucleotidyl-transferase-mediated deoxy-UTP nick end labelling (TUNEL) and by immunostaining of cleaved caspases. We observed the development of osteoarthritis in Atg5cKO mice with aging including fibrillation and loss of proteoglycans, which was particularly severe in males. The ablation of Atg5 was associated with an increased cell death as assessed by TUNEL, cleaved caspase 3 and cleaved caspase 9. Surprisingly, no difference in the development of post-traumatic osteoarthritis was observed between Atg5cKO and control mice. Autophagy protects from age-related osteoarthritis by facilitating chondrocyte survival. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  8. Efficiency and the public interest: QF transmission and the Energy Policy Act of 1992

    International Nuclear Information System (INIS)

    Fox-Penner, P.

    1993-01-01

    Prior to the enactment of the Energy Policy Act of 1992 (Act), most Federal Energy Regulatory Commission (FERC or Commission) deliberations involving transmission services did not occur in transmission rate or service proceedings per se. The Commission conducted a number of general inquiries or studies of the subject, including setting the terms and conditions of transmission services as part of merger proceedings and open-quotes market-basedclose quotes pricing proceedings. With the passage of the Act, the FERC is likely to be asked to confront the advisability of requiring transmission services in a more direct manner. The Act permits open-quotes[a]ny electric utility, Federal power marketing agency, or any other person generating electrical energy for sale for resaleclose quotes to petition the Commission for a wheeling order. The FERC may order wheeling in accordance with section 212 of the Federal Power Act (FPA) and a finding that such wheeling would open-quotes otherwise be in the public interest.close quotes When compounded with the need to find that wheeling is in the public interest, the requirements set forth in section 212 are considerable. This article focuses on an important area of section 212 criteria, namely the interplay between between the public interest and economic efficiency criteria in the case of Public Utility Regulatory Policies Act of 1978 (PURPA) Qualifying Facilities (QF). Two recent proceedings in which the FERC considered the need to provide power transmission service guarantees for QFs are analyzed from the standpoint of public and private economic welfare. The two proceedings are the merger of Utah Power ampersand Light Company, PacifiCorp, PC/UP ampersand L Merging Corporation (Utah) and the Western Systems Power Pool application (WSPP)

  9. Regulatory restrictions and energy: The impact of the Jones Act on spot gasoline prices

    International Nuclear Information System (INIS)

    Gius, Mark

    2013-01-01

    The purpose of the present study is to estimate the effects of the Jones Act on spot gasoline prices. Although the Jones Act pertains to the domestic shipment of all types of goods, the present study will only focus on gasoline. The present study will use data obtained from the Energy Information Administration in order to determine if the price of gasoline declined during Jones Act waiver periods. Looking at daily prices, the results regarding the effects of the Jones Act on spot gasoline prices are mixed. When using a t-test, the results indicated either that there was no significant difference or that prices were actually higher during the waiver periods. When using a first-order autoregressive model, it was found that prices were lower during the 2005 waiver period but higher during the 2012 waiver. Given these inconclusive results, it is not possible to conclude that the Jones Act restrictions contribute to higher gasoline prices. - Highlights: • I examine the effect of the Jones Act on spot gasoline prices. • I use daily price data over a seven year period. • I find that the results are mixed. • For the Hurricane Katrina waiver, prices fell, but for the Hurricane Sandy waiver, prices rose

  10. Schedule to Nuclear Energy Act no 92, 1982: no. R. 1132, 13 Jun 1986

    International Nuclear Information System (INIS)

    1986-01-01

    This is a schedule to the Nuclear Energy Act, 1982 (Act no. 92 of 1982). In the event of a nuclear accident the corporation must keep clear records of the persons affected by such accidents, as well as information such as the place, date, time and nature of a nuclear accident. Records must be copied, reproduced or transcribed by the corporation and must be kept in such a durable manner that the records will remain suitable to be submitted at any time during a period of 30 years

  11. Slovak Republic act No. 541/2004 of 9 September 2004 on the peaceful use of nuclear energy (Atomic act) and on alterations and amendments to some acts

    International Nuclear Information System (INIS)

    2004-01-01

    This Atomic act contains: Part I: Basic provisions; Paragraph (P) 1: Subject of act; P2: Definition of certain terms; P3: Principles od peaceful use of nuclear energy. Part II: State Administration, state supervision and competencies of the Authority; P4: Competence of the Authority; P5: Use of nuclear energy; P6: Application for permission or authorisation; P7: Permission or authorisation issuance conditions; P8: Essentials and issuance of permission or authorisation; P9: Modification, cancellation or extinction of permission or authorisation; P10: Duties of the authorisation holder; Part III: Nuclear materials, special materials and equipment, and shipment of radioactive materials; P11: Nuclear materials, special materials and equipment; P12: Management of nuclear materials; P13: Record keeping system and control of nuclear materials; P14: Import and export of nuclear materials, special materials and equipment; P15: Shipment of radioactive materials; P16: Shipment of radioactive waste between Member States and from and to the Community. Part IV: Nuclear installations; P17: Siting of nuclear installations; P18: Building permission for the construction of nuclear installations; P19: Commissioning of nuclear installations and operation of nuclear installations; P20: Decommissioning. Part V: Management of radioactive waste and spent fuel: P21: Management of radioactive waste and spent fuel; P22: Repository closure and institutional measures. Part VI: Nuclear safety, professional competency, quality assurance, physical protection, operational events and emergency preparedness: P23: Nuclear safety; P24: Professional competency; P25: Quality assurance; P26: Physical protection; P27: Operational events at nuclear installation and events during shipment of radioactive materials; P28: Emergency planning and emergency preparedness. Part VII: Liability for nuclear damage and financial coverage there of: P29: Liability for nuclear damage; P30: Financial coverage of liability

  12. Enerplan, Professional association of solar energy - activity report 2008. Acting for solar energy promotion and development

    International Nuclear Information System (INIS)

    2009-01-01

    Enerplan is the French union of solar energy professionals. Created in 1983, its social purpose is the study and defense of the rights and of the material and moral interests of its members. Enerplan structures its action through two poles representing members' activities: 'solar energy and building' where topics about heat and electricity generation in relation with buildings are treated, and 'photovoltaic energy' where topics specific to big solar power plants are considered. Thanks to the collaborative participation of its members, both poles allow Enerplan union to be source of proposals to develop solar energy in France. As an active interface between professionals and institutions, Enerplan includes in its membership: industrialists, plant makers, engineering consultants, installers, associations, energy suppliers etc, from small-medium size companies to big groups. This document presents Enerplan's activities in 2008 (public relations, lobbying, meetings and conferences, promotional activities, collaborations, projects..)

  13. Priority to renewable energies - on the amendment to the renewable energies act

    International Nuclear Information System (INIS)

    Heller, W.

    2003-01-01

    The Federal Ministry for the Environment, which has been the competent authority for renewable energies since the 2002 federal election, has presented draft legislation on the accelerated development of renewable energies in the electricity sector. This is to reduce, through internalization, the costs to the national economy arising from power supply, to conserve nature and the environment, avoid conflicts over fossil energy resources, and promote the advanced development of renewable energy technologies. Emphasis is put solely on protection of the climate and of the environment. The way towards sustainable energy supply by taking into account ecological, economic and social aspects is abandoned. The funding rates laid down in legislation are not going to offer major incentives for further plant improvement by technological development. The quantitative goals of this draft legislation onesidedly aimed at electricity production are doubtful. Renewable energies are hardly the right way to replace nuclear power plants operated in the baseload mode. What is missing in the draft legislation, though it would be urgently needed, is a clear time limit on the eligibility of renewable energy plants for subsidizing, as this would counteract the impression of permanent subsidizing. (orig.)

  14. On the reform of the regulations in the Atomic Energy Act concerning governmental supervision

    International Nuclear Information System (INIS)

    Rebentisch, M.

    1991-01-01

    The deliberations on the amendment to the Atomic Energy Act aim at a harmonization with the Federal Immission Control Act. This holds especially for the area of regulations dealing with the installation. With its function as a licensing law for industrial installations the Federal Immission Control Act has a key position in technology and safety law. The lecture deals especially with the obligation to inform and with the right of the supervising authority to reserve its consent to minor alterations; legal qualification and lawfulness of the reservation of consent; reservation of consent to the start-up after an exchange of fuel elements; requirement of a permit for the decommissioning of installations. (orig./HSCH) [de

  15. Atg5 Is Essential for the Development and Survival of Innate Lymphocytes

    Directory of Open Access Journals (Sweden)

    Timothy E. O’Sullivan

    2016-05-01

    Full Text Available Autophagy is an essential cellular survival mechanism that is required for adaptive lymphocyte development; however, its role in innate lymphoid cell (ILC development remains unknown. Furthermore, the conditions that promote lymphocyte autophagy during homeostasis are poorly understood. Here, we demonstrate that Atg5, an essential component of the autophagy machinery, is required for the development of mature natural killer (NK cells and group 1, 2, and 3 innate ILCs. Although inducible ablation of Atg5 was dispensable for the homeostasis of lymphocyte precursors and mature lymphocytes in lymphoreplete mice, we found that autophagy is induced in both adaptive and innate lymphocytes during homeostatic proliferation in lymphopenic hosts to promote their survival by limiting cell-intrinsic apoptosis. Induction of autophagy through metformin treatment following homeostatic proliferation increased lymphocyte numbers through an Atg5-dependent mechanism. These findings highlight the essential role for autophagy in ILC development and lymphocyte survival during lymphopenia.

  16. RIP3 attenuates the pancreatic damage induced by deletion of ATG7.

    Science.gov (United States)

    Zhou, Xiaodong; Xie, Li; Xia, Leizhou; Bergmann, Frank; Büchler, Markus W; Kroemer, Guido; Hackert, Thilo; Fortunato, Franco

    2017-07-13

    Invalidation of pancreatic autophagy entails pancreatic atrophy, endocrine and exocrine insufficiency and pancreatitis. The aim of this study was to investigate whether depletion of Rip3, which is involved in necroptotic signaling, may attenuate the pancreatic atrophy and pancreatitis resulting from autophagy inhibition. Autophagy and necroptosis signaling were evaluated in mice lacking expression of Rip3 in all organs and Atg7 in the pancreas. Acinar cell death, inflammation and fibrosis were evaluated by using of a compendium of immunofluorescence methods and immunoblots. Mice deficient for pancreatic Atg7 developed acute pancreatitis, which progressed to chronic pancreatitis. This phenotype reduces autophagy, increase apoptosis and necroptosis, inflammation and fibrosis, as well as premature death of the animals. Knockout of Rip3 exacerbated the apoptotic death of acinar cells, increased tissue damage, reduced macrophage infiltration and further accelerated the death of the mice with Atg7-deficient pancreas. The pancreatic degeneration induced by autophagy inhibition was exacerbated by Rip3 deletion.

  17. Interactions between Energy Efficiency Programs funded under the Recovery Act and Utility Customer-Funded Energy Efficiency Programs

    Energy Technology Data Exchange (ETDEWEB)

    Goldman, Charles A.; Stuart, Elizabeth; Hoffman, Ian; Fuller, Merrian C.; Billingsley, Megan A.

    2011-02-25

    Since the spring of 2009, billions of federal dollars have been allocated to state and local governments as grants for energy efficiency and renewable energy projects and programs. The scale of this American Reinvestment and Recovery Act (ARRA) funding, focused on 'shovel-ready' projects to create and retain jobs, is unprecedented. Thousands of newly funded players - cities, counties, states, and tribes - and thousands of programs and projects are entering the existing landscape of energy efficiency programs for the first time or expanding their reach. The nation's experience base with energy efficiency is growing enormously, fed by federal dollars and driven by broader objectives than saving energy alone. State and local officials made countless choices in developing portfolios of ARRA-funded energy efficiency programs and deciding how their programs would relate to existing efficiency programs funded by utility customers. Those choices are worth examining as bellwethers of a future world where there may be multiple program administrators and funding sources in many states. What are the opportunities and challenges of this new environment? What short- and long-term impacts will this large, infusion of funds have on utility customer-funded programs; for example, on infrastructure for delivering energy efficiency services or on customer willingness to invest in energy efficiency? To what extent has the attribution of energy savings been a critical issue, especially where administrators of utility customer-funded energy efficiency programs have performance or shareholder incentives? Do the new ARRA-funded energy efficiency programs provide insights on roles or activities that are particularly well-suited to state and local program administrators vs. administrators or implementers of utility customer-funded programs? The answers could have important implications for the future of U.S. energy efficiency. This report focuses on a selected set of ARRA

  18. Main aspects of the planned reform of the Act on the Peaceful Uses of Atomic Energy and Protection against its Hazards (Atomic Energy Act)

    International Nuclear Information System (INIS)

    Lukes, R.

    1991-01-01

    There is no specific reason for planning a reform of the atomic energy law just now; the main idea is to keep the atomic energy law abreast with the developments made in the regime of protective laws pertaining to the sector of science and technology. A further aspect not to be neglected, however, is the nuclear power phase-out currently under debate, and a decision against the abandonment of nuclear power should be taken as an occasion to think about a nuclear law reform. The judiciary has been contributing to the development of nuclear law in the last years, and the decisions of the Federal Constitutional Court and of the Federal Administrative Court have not only set the corner flags for the future development of the nuclear law, but have given concrete shape by final settlement of cases of divergence of judicial decisions, to the protective intents of the law and to the subject-related purposes. Thus the judiciary has been taking into account the idea prevailing today, namely that the scope of duties of the Federal Government certainly includes the task of protecting the citizens against the hazards of technology in general, and of novel technologies in particular, and the task of avoiding hazards. So the main line of orientation to be pursued is to draw level with protective regulations established in other fields of law, and to make the Atomic Energy Act a modern instrument of protection by the law. (orig./HSCH) [de

  19. Targeted deletion of Atg5 reveals differential roles of autophagy in keratin K5-expressing epithelia

    Energy Technology Data Exchange (ETDEWEB)

    Sukseree, Supawadee [Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna (Austria); Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok (Thailand); Rossiter, Heidemarie; Mildner, Michael [Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna (Austria); Pammer, Johannes [Institute of Clinical Pathology, Medical University of Vienna, Vienna (Austria); Buchberger, Maria; Gruber, Florian [Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna (Austria); Watanapokasin, Ramida [Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok (Thailand); Tschachler, Erwin [Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna (Austria); Eckhart, Leopold, E-mail: leopold.eckhart@meduniwien.ac.at [Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna (Austria)

    2013-01-11

    Highlights: Black-Right-Pointing-Pointer We generated mice lacking Atg5 and autophagy in keratin K5-positive epithelia. Black-Right-Pointing-Pointer Suppression of autophagy in thymic epithelium was not associated with signs of autoimmunity. Black-Right-Pointing-Pointer Autophagy was required for normal terminal differentiation of preputial gland cells. Black-Right-Pointing-Pointer Autophagy-deficient cells of the preputial glands degraded nuclear DNA prematurely. -- Abstract: Autophagy contributes to the homeostasis of many tissues, yet its role in epithelia is incompletely understood. A recent report proposed that Atg5-dependent autophagy in thymic epithelial cells is essential for their function in the negative selection of self-reactive T-cells and, thus, for the suppression of tissue inflammation. Here we crossed mice carrying floxed alleles of the Atg5 gene with mice expressing the Cre recombinase under the control of the keratin K5 promoter to suppress autophagy in all K5-positive epithelia. The efficiency of autophagy abrogation was confirmed by immunoanalyses of LC3, which was converted to the autophagy-associated LC3-II form in normal but not Atg5-deficient cells, and of p62, which accumulated in Atg5-deficient cells. Mice carrying the epithelium-specific deletion of Atg5 showed normal weight gain, absence of tissue inflammation, and a normal morphology of the thymic epithelium. By contrast, autophagy-deficient epithelial cells of the preputial gland showed aberrant eosinophilic staining in histology and premature degradation of nuclear DNA during terminal differentiation. Taken together, the results of this study suggest that autophagy is dispensable for the suppression of autoimmunity by thymic epithelial cells but essential for normal differentiation of the preputial gland in mice.

  20. A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3

    Science.gov (United States)

    Murthy, Aditya; Li, Yun; Peng, Ivan; Reichelt, Mike; Katakam, Anand Kumar; Noubade, Rajkumar; Roose-Girma, Merone; Devoss, Jason; Diehl, Lauri; Graham, Robert R.; van Lookeren Campagne, Menno

    2014-02-01

    Crohn's disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract. A single-nucleotide polymorphism (SNP) encoding a missense variant in the autophagy gene ATG16L1 (rs2241880, Thr300Ala) is strongly associated with the incidence of Crohn's disease. Numerous studies have demonstrated the effect of ATG16L1 deletion or deficiency; however, the molecular consequences of the Thr300Ala (T300A) variant remains unknown. Here we show that amino acids 296-299 constitute a caspase cleavage motif in ATG16L1 and that the T300A variant (T316A in mice) significantly increases ATG16L1 sensitization to caspase-3-mediated processing. We observed that death-receptor activation or starvation-induced metabolic stress in human and murine macrophages increased degradation of the T300A or T316A variants of ATG16L1, respectively, resulting in diminished autophagy. Knock-in mice harbouring the T316A variant showed defective clearance of the ileal pathogen Yersinia enterocolitica and an elevated inflammatory cytokine response. In turn, deletion of the caspase-3-encoding gene, Casp3, or elimination of the caspase cleavage site by site-directed mutagenesis rescued starvation-induced autophagy and pathogen clearance, respectively. These findings demonstrate that caspase 3 activation in the presence of a common risk allele leads to accelerated degradation of ATG16L1, placing cellular stress, apoptotic stimuli and impaired autophagy in a unified pathway that predisposes to Crohn's disease.

  1. Use of ATG-Fresenius as an Induction Agent in Deceased-Donor Kidney Transplantation.

    Science.gov (United States)

    Yilmaz, M; Sezer, T Ö; Kir, O; Öztürk, A; Hoşcoşkun, C; Töz, H

    2017-04-01

    Anti-T-lymphocyte globulins (ATG) are most commonly used as induction agents in kidney transplantation (KT). In this study, we investigated the use of ATG as induction therapy in deceased-donor KT. Among 152 deceased-donor KT recipients transplanted between January 2009 and December 2003, 147 with exact data were enrolled in this study. Delayed graft function was defined as dialysis requirement after KT. Greater than 10% panel-reactive antibody (PRA) was considered as positive. Total ATG (rATG-Fresenius) dosage and induction duration was evaluated. Mean age was 45 ± 10 years; 91 patients were male and 56 patients were female. Class I and class II PRA-positive patient numbers were 20 (13.6%) and 17 (11.5%), respectively. Pre-transplant dialysis vintage was 108 ± 63 months. Mean donor age was 42 ± 17, and cold ischemia time was 16 ± 5 hours. Eighty-nine patients (60%) had delayed graft function and needed at least one session of hemodialysis after transplantation. Cumulative ATG-F dosage was 676 ± 274 mg. The mean ATG-F cumulative dosage was 10.6 ± 3.8 mg/kg. At the end of first year, mean creatinine and proteinuria levels were 1.4 ± 1.0 mg/dL and 0.3 ± 0.4 g/d, respectively. Mean follow-up time was 32 ± 20 months. During follow-up, there were 14 graft failures and 11 patients died. Patient survival for 1 and 2 years were 93% and 92.3%, respectively. Death-censored graft survival rates for 1 and 2 years were 94.8% and 90.8%, respectively. ATG-F induction provides acceptable graft and patient survival in deceased-donor KT. ATG-F infusion is well tolerated. Infection rates seem to be acceptable compared with all transplantation populations. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. 6-methylprednisolone does not impair anti-thymocyte globulin (ATG) immunosuppressive activity in non-human primates

    NARCIS (Netherlands)

    Preville, [No Value; Sick, E; Beauchard, S; Ossevoort, M; Tiollier, J; Revillard, JP; Jonker, Margreet

    2001-01-01

    Background: Induction treatments with anti-thymocyte globulin (ATG) in solid organ transplantation may enhance the efficacy of maintenance immunosuppressive therapy. Since ATG can trigger Fas (CD95) mediated T cell apoptosis, a process antagonized in vitro by corticosteroids, an important issue is

  3. The Energy Policy Act of 1992 and reductions in greenhouse gas emissions: The petroleum industry perspective

    International Nuclear Information System (INIS)

    Baer, M.T.

    1994-01-01

    The Energy Policy Act of 1992 (EPAct) directs the US Department of Energy policies, programs and regulations to stabilize and reduce the quantities of greenhouse gas emissions. These objectives will be accomplished through the regulation of sources associated with the production, transportation/distribution, and end-use of energy resources. Almost all of the 30 titles of the Act affect these sources: from the energy efficiency provisions of Titles 1 and XXI to the alternative fuels and vehicles programs of Titles 3 through 5; from the global climate change requirements of Title XVI to the petroleum alternative research programs of Titles VI, XII, XIII, XX, and XXI; and from the multiple titles pertaining to the development and regulation of nuclear facilities, supplies, and waste. The goals of the law are to: (1) reduce the use of oil in the domestic energy mix from 40% in 1990 to 35% by the year 2005, (2) require the use of alternative fuels and alternative fuel vehicles in designated fleets, (3) replace up to 30% of motor fuels with ''replacement fuels'' by the year 2010, (4) increase the overall efficiency of consumer, residential, and commercial products, (5) reduce and stabilize the emissions of greenhouse gases, and (6) encourage the development and commercialization of renewable and non petroleum energy resources. All these goals are intended to reduce the emissions of greenhouse gases as well. The EPAct's potential to impact all forms of energy and all energy producers and suppliers is obvious and substantial. This paper assesses three goals of the EPAct, now under study by the petroleum industry, that will affect the production, supply, composition, and use of petroleum products, most notably gasoline and natural gas

  4. Atg6/UVRAG/Vps34-Containing Lipid Kinase Complex Is Required for Receptor Downregulation through Endolysosomal Degradation and Epithelial Polarity during Drosophila Wing Development

    Directory of Open Access Journals (Sweden)

    Péter Lőrincz

    2014-01-01

    Full Text Available Atg6 (Beclin 1 in mammals is a core component of the Vps34 PI3K (III complex, which promotes multiple vesicle trafficking pathways. Atg6 and Vps34 form two distinct PI3K (III complexes in yeast and mammalian cells, either with Atg14 or with UVRAG. The functions of these two complexes are not entirely clear, as both Atg14 and UVRAG have been suggested to regulate both endocytosis and autophagy. In this study, we performed a microscopic analysis of UVRAG, Atg14, or Atg6 loss-of-function cells in the developing Drosophila wing. Both autophagy and endocytosis are seriously impaired and defective endolysosomes accumulate upon loss of Atg6. We show that Atg6 is required for the downregulation of Notch and Wingless signaling pathways; thus it is essential for normal wing development. Moreover, the loss of Atg6 impairs cell polarity. Atg14 depletion results in autophagy defects with no effect on endocytosis or cell polarity, while the silencing of UVRAG phenocopies all but the autophagy defect of Atg6 depleted cells. Thus, our results indicate that the UVRAG-containing PI3K (III complex is required for receptor downregulation through endolysosomal degradation and for the establishment of proper cell polarity in the developing wing, while the Atg14-containing complex is involved in autophagosome formation.

  5. Single-shot, high-dose rabbit ATG for rejection prophylaxis after kidney transplantation

    NARCIS (Netherlands)

    R. Zietse (Bob); E.P.M. van Steenberge (E. P M); C.J. Hesse (Cees); L.B. Vaessen (L.); J.N.M. IJzermans (Jan); W. Weimar (Willem)

    1993-01-01

    textabstractWe studied the effects of a single intravenous injection of rabbit ATG (RIVM, Bilthoven, The Netherlands) in a dose of 8 mg/kg body weight administered 6 h after kidney transplantation on graft survival, rejection incidence, T-cell subsets, and cost-effectiveness. A total of 58 (37

  6. The Energy Sector in Slovenia Two Years After the Adoption of the Energy Act

    International Nuclear Information System (INIS)

    Sencar, M.

    2001-01-01

    This paper describes the legal situation, status and main characteristics of the current Slovenian energy sector. The pace of change has encompassed the companies which have been unbundled, the authorities which have prepared the main secondary legislation, and the new independent regulatory authority which has adopted its own regulations. Power exchange has been established, and the first transactions have been undertaken. Main characteristics of the process of the market opening, status and main rules of both electricity and gas market are described. The regulatory agency has developed conditions for participation particularly in licensing and use of network charges. There are still some open questions and documents which remain to be produced, as discussed in the paper below.(author)

  7. Membrane morphology is actively transformed by covalent binding of the protein Atg8 to PE-lipids.

    Directory of Open Access Journals (Sweden)

    Roland L Knorr

    Full Text Available Autophagy is a cellular degradation pathway involving the shape transformation of lipid bilayers. During the onset of autophagy, the water-soluble protein Atg8 binds covalently to phosphatdylethanolamines (PEs in the membrane in an ubiquitin-like reaction coupled to ATP hydrolysis. We reconstituted the Atg8 conjugation system in giant and nm-sized vesicles with a minimal set of enzymes and observed that formation of Atg8-PE on giant vesicles can cause substantial tubulation of membranes even in the absence of Atg12-Atg5-Atg16. Our findings show that ubiquitin-like processes can actively change properties of lipid membranes and that membrane crowding by proteins can be dynamically regulated in cells. Furthermore we provide evidence for curvature sorting of Atg8-PE. Curvature generation and sorting are directly linked to organelle shapes and, thus, to biological function. Our results suggest that a positive feedback exists between the ubiquitin-like reaction and the membrane curvature, which is important for dynamic shape changes of cell membranes, such as those involved in the formation of autophagosomes.

  8. Decree of 29 August 1969, Stb. 358, concerning the implementation of Section 1 of the Nuclear Energy Act (Definitions)

    International Nuclear Information System (INIS)

    1969-01-01

    In implementation of Section 1 of the Nuclear Energy Act, this Decree lays down the percentages of uranium, plutonium and thorium substances must contain to be classified as fissionable materials under the Act. It provides for more detailed definitions of non-irradiated materials, natural, enriched and depleted uranium and ionizing radiations. (NEA) [fr

  9. Decree of 16 October 1969, Stb. 475, concerning the implementation of Section 74 of the Nuclear Energy Act (Contributions)

    International Nuclear Information System (INIS)

    1969-01-01

    In accordance with the Nuclear Energy Act, this Decree determines the amount of contributions required towards the costs incurred by the State in implementation of the Act. Contributions are required when licences are granted, when packaging must be approved and when materials are transported. (NEA) [fr

  10. Upregulation of autophagy-related gene-5 (ATG-5 is associated with chemoresistance in human gastric cancer.

    Directory of Open Access Journals (Sweden)

    Jie Ge

    Full Text Available Autophagy-related gene-5 (ATG-5 is one of the key regulators of autophagic cell death. It has been widely regarded as a protective molecular mechanism for tumor cells during the course of chemotherapy. In the present study, we investigated the expression pattern of ATG-5 and multidrug resistance-associated protein-1 (MRP-1 in 135 gastric cancers (GC patients who were treated with epirubicin, cisplatin and 5-FU adjuvant chemotherapy (ECF following surgical resection and explored their potential clinical significance. We found that both ATG-5 (77.78% and MRP-1 (79.26% were highly expressed in GC patients. ATG-5 expression was significantly associated with depth of wall invasion, TNM stages and distant metastasis of GC (P<0.05, whereas MRP-1 expression was significantly linked with tumor size, depth of wall invasion, lymph node metastasis, TNM stages and differentiation status (P<0.05. ATG-5 expression was positively correlated with MRP-1 (rp = 0.616, P<0.01. Increased expression of ATG-5 and MPR-1 was significantly correlated with poor overall survival (OS; P<0.01 and disease free survival (DFS; P<0.01 of our GC cohort. Furthermore, we demonstrated that ATG-5 was involved in drug resistant of GC cells, which was mainly through regulating autophagy. Our data suggest that upregulated expression of ATG-5, an important molecular feature of protective autophagy, is associated with chemoresistance in GC. Expression of ATG-5 and MRP-1 may be independent prognostic markers for GC treatment.

  11. ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei.

    Directory of Open Access Journals (Sweden)

    Ana Brennand

    Full Text Available We have previously identified homologs for nearly half of the approximately 30 known yeast Atg's in the genome database of the human sleeping sickness parasite Trypanosoma brucei. So far, only a few of these homologs have their role in autophagy experimentally confirmed. Among the candidates was the ortholog of Atg24 that is involved in pexophagy in yeast. In T. brucei, the peroxisome-like organelles named glycosomes harbor core metabolic processes, especially glycolysis. In the autotrophic yeast, autophagy is essential for adaptation to different nutritional environments by participating in the renewal of the peroxisome population. We hypothesized that autophagic turnover of the parasite's glycosomes plays a role in differentiation during its life cycle, which demands adaptation to different host environments and associated dramatic changes in nutritional conditions. We therefore characterized T. brucei ATG24, the T. brucei ortholog of yeast Atg24 and mammalian SNX4, and found it to have a regulatory role in autophagy and differentiation as well as endocytic trafficking. ATG24 partially localized on endocytic membranes where it was recruited via PI3-kinase III/VPS34. ATG24 silencing severely impaired receptor-mediated endocytosis of transferrin, but not adsorptive uptake of a lectin, and caused a major enlargement of the flagellar pocket. ATG24 silencing approximately doubled the number of autophagosomes, suggesting a role in repressing autophagy, and strongly accelerated differentiation, in accordance with a role of autophagy in parasite differentiation. Overexpression of the two isoforms of T. brucei ATG8 fused to GFP slowed down differentiation, possibly by a dominant-negative effect. This was overcome by ATG24 depletion, further supporting its regulatory role.

  12. Impact of the resource conservation and recovery act on energy facility siting

    International Nuclear Information System (INIS)

    Tevepaugh, C.W.

    1982-01-01

    The Resource Conservation and Recovery Act (RCRA) of 1976 is a multifaceted approach to the management of both solid and hazardous waste. The focus of this research is on the RCRA mandated proposed regulations for the siting of hazardous waste disposal facilities. This research is an analysis of the interactions among hazardous waste disposal facilities, energy supply technologies and land use issues. This study addresses the impact of RCRA hazardous waste regulations in a descriptive and exploratory manner. A literature and legislative review, interviews and letters of inquiry were synthesized to identify the relationship between RCRA hazardous waste regulations and the siting of selected energy supply technologies. The results of this synthesis were used to determine if and how RCRA influences national land use issues. It was found that the interaction between RCRA and the siting of hazardous waste disposal facilities required by energy supply technologies will impact national land use issues. All energy supply technologies reviewed generate hazardous waste. The siting of industrial functions such as energy supply facilities and hazardous waste disposal facilities will influence future development patterns. The micro-level impacts from the siting of hazardous waste disposal facilities will produce a ripple effect on land use with successive buffer zones developing around the facilities due to the interactive growth of the land use sectors

  13. Rutin (quercetin rutinoside) induced protein-energy malnutrition in chronic kidney disease, but quercetin acted beneficially.

    Science.gov (United States)

    Hsieh, Chiu-Lan; Peng, Chiung-Chi; Chen, Kuan-Chou; Peng, Robert Y

    2013-07-31

    Nutraceutically, much of the literature has indicated that an aglycon and its related glycoside would act similarly. However, controversial reports are accumulating. We hypothesize that rutin (RT) and quercetin (QT) pharmacodynamically could act differently. To confirm this, doxorubicin (DR) (8.5 mg/kg) was used to induce rat chronic kidney disease (CKD) and then treated with QT and RT (each 70 mg/kg body weight per day) for 13 weeks. QT exhibited better body weight gaining effect (420 ± 45) vs RT, 350 ± 57 g/rat (p protein-energy malnutrition". RT stimulated serum creatinine (sCr) production to reach 6.0 ± 0.9 mg/dL (p < 0.001). QT did not alter the sCr level. RT but not QT induced uremia and hypercreatininemia. DR significantly downregulated Bcl-2, but highly upregulated Bax, Bad, and cleaved caspase-3, implicating the intrinsic mitochondrial pathway. DR damaged DNA, but QT completely rescued such an effect and recovered renal amyloidosis and collagen deposition. Conclusively, RT and QT act differently, and RT is inferior to QT with respect to treating CKD.

  14. Residual risks of the 13th amendment to the German Atomic Energy Act

    International Nuclear Information System (INIS)

    Schneider, Horst

    2011-01-01

    The 13th amendment to the German Atomic Energy Act, which was adopted by the German federal parliament on June 30 and entered into force on August 6, 2011, must be judged in the light of its genesis. Federal Chancellor Merkel, in her government declaration of June 9, 2011, had mentioned topics such as residual risk, safety standards, and risk assumptions, on which the federal government, in the week after the event of March 11, 2011, had commissioned the Advisory Committee on Reactor Safeguards (RSK) to conduct a comprehensive safety review of all German nuclear power plants, and appointed an Ethics Committee to write an opinion on safe energy supply. On the basis of quickly drafted reports, the federal cabinet, without any international harmonization (EU, IEA), adopted a draft opt out law on June 6, 2011. How should the declarations by the Federal Chancellor on June 9, 2011 be classified in terms of atomic energy law? In her words, it all revolved around the residual risk. The debate, which has been shifted to the realm of constitutional law, is open to considerations and steps to attack the new opt out law on grounds of material unconstitutionality (violation of the property guarantee under Sec. 14 or the principle of equality under Art.3 of the Basic Law). As far as final storage is concerned, the amendment to the German Atomic Energy Act announced still for this year, also for transposition of the EURATOM Directive of July 19, 2011 about nuclear waste management, the ''re-assessment of the residual risk'' is not likely to play a role. All these events are reminiscent of a sentence by former Federal Chancellor Schmidt: ''The history of the NATO dual-track decision remains a textbook case showing that even in a democracy emotions using ethical arguments, mixed with demagogy, can become strong enough to cast aside balanced reason.'' There is also a distinction by Max Weber between ''ethics of ideology'' and ''ethics of responsibility''. (orig.)

  15. Identification, molecular cloning and expression analysis of a HORMA domain containing Autophagy-related gene 13 (ATG13 from the coleopteran beetle, Tenebrio molitor

    Directory of Open Access Journals (Sweden)

    Jung Hee eLee

    2015-06-01

    Full Text Available Autophagy is a process that is necessary during starvation as it replenishes metabolic precursors by eliminating damaged organelles. Autophagy is mediated by more than 35 autophagy-related (Atg proteins that manifest in the nucleation, elongation, and curving of autophagosome membrane. We isolated a homolog of an ATG13 gene from the transcriptome database of the larva of the mealworm beetle, Tenebrio molitor (designated as TmATG13. The sequence analysis showed that TmATG13 cDNA comprises of 1,176 bp open reading frame that encodes a protein of 391 amino acids. Analyses of the structure-specific features of TmAtg13 showed an intrinsically disordered middle and C-terminal region, rich in regulatory phosphorylation sites. The N-terminal Atg13 domain show a HORMA (Hop1, Rev7, and Mad2 fold containing conserved amino acid residues across the Atg13 orthologs in insects. qRT-PCR revealed that TmATG13 was expressed ubiquitously in all the developmental stages of insect. TmATG13 mRNA expression was high in fat body and gut of the larval and adult stages of the insect. During ovary development and maturation, the TmATG13 transcripts showed high expression until six days of development, followed by a significant decline. The prospective functions mediated by TmAtg13 during autophagy will be clarified by further studies in the near future.

  16. Full of hardship: On the hardship clause in the renewable energies act

    International Nuclear Information System (INIS)

    Heller, W.

    2003-01-01

    The German Federal Supreme Court (BGH) on June 11, 2003 ruled on cases in which operators of wind power plants had demanded that an electricity utility buy their wind power generated electricity. In line with earlier decisions, the BGH ruled that the legal requirement to buy this electricity was constitutional under the Renewable Energies Act (EEG) and the Electricity Feeding Act. This ruling further cements the principle of private parties subsidizing third parties under the EEG. The legal minimum prices for wind power generated electricity under the EEG are considerably above the market price of conventional electricity and, thus, have caused a boom in the construction of more wind power plants. The volume of payments for feeding into the public grid electricity from wind power plants reached the amount of Euro 1.530 billion in 2002, which is an average extra cost of, at present, Euro cent 0.46 per kWh. Given a 20-year period of subsidizing individual plants, double-digit billions are expected to arise as financial burdens over the next few decades. The German federal government introduced a proposal of an EEG hardship clause. This is unlikely to relieve industries of EEG burdens on a broad basis. Besides present economic burdens, also the sustainability of this kind of energy policy is doubtful, both from economic and social points of view. (orig.)

  17. Advanced mechanisms for the promotion of renewable energy-Models for the future evolution of the German Renewable Energy Act

    International Nuclear Information System (INIS)

    Langniss, Ole; Diekmann, Jochen; Lehr, Ulrike

    2009-01-01

    The German Renewable Energy Act (EEG) has been very successful in promoting the deployment of renewable electricity technologies in Germany. The increasing share of EEG power in the generation portfolio, increasing amounts of fluctuating power generation, and the growing European integration of power markets governed by competition calls for a re-design of the EEG. In particular, a more efficient system integration and commercial integration of the EEG power is needed to, e.g. better matching feed-in to demand and avoiding stress on electricity grids. This article describes three different options to improve the EEG by providing appropriate incentives and more flexibility to the promotion mechanism and the quantitative compensation scheme without jeopardising the fast deployment of renewable energy technologies. In the 'Retailer Model', it becomes the responsibility of the end-use retailers to adapt the EEG power to the actual demand of their respective customers. The 'Market Mediator Model' establishes an independent market mediator responsible to market the renewable electricity. This model is the primary choice when new market entrants are regarded as crucial for the better integration of renewable energy and enhanced competition. The 'Optional Bonus Model' relies more on functioning markets since power plant operators can alternatively choose to market the generated electricity themselves with a premium on top of the market price instead of a fixed price

  18. Atg12 Maintains Skeletal Integrity by Modulating Pro-Osteoclastogenic Signals and Chondrocyte Differentiation

    Science.gov (United States)

    Tahimic, Candice; Bahl, Disha; Shirazi-Fard, Yasaman; Marsh, Timothy; Schreurs, Anne-Sofie; Rael, Victoria E.; Glikbarg, Chloe; Debnath, Jayantha; Globus, Ruth K.

    2016-01-01

    Weightlessness and radiation, two unique elements of space, profoundly decreases bone mass. This bone loss is attributed to increased activity of bone-resorbing osteoclasts and functional changes in bone-forming osteoblasts, cells that give rise to mature osteocytes. Our long-term goal is to identify signaling pathways that may be targeted to mitigate bone loss in scenarios of space exploration, radiotherapy and accidental radiation exposure. We have previously shown that exposure of MLO-Y4 osteocyte-like cells to simulated space radiation (56Fe) increased the expression of the pro-osteoclastogenic gene rankl and decreased protein levels of LC3B-II, a key player in autophagy. In this current study, we aimed to further elucidate the role of autophagy in maintaining structural integrity of the skeleton. We hypothesize that loss of autophagy in bone leads to an imbalance in pro-osteoclastogenic and pro-osteogenic signals, resulting in net bone loss. To test our hypothesis we performed global postnatal deletion of Atg12 using tamoxifeninducible Cre recombinase under the control of the CAG promoter. Six-week-old CAGCreERT2/ FloxAtg12 animals were treated daily with Tamoxifen or Vehicle (Control, oil only) for five days and euthanasia performed two weeks after the onset of treatment. Percent change in body weights (prior to treatment and at euthanasia) was not significantly different between treatment groups within the same gender. Compared to Vehicle (Control) groups, Tamoxifen (Atg12 iKO) groups showed decreased LC3B-I to II conversion and increased p62 protein levels, consistent with loss of autophagy. Quantitative PCR revealed increased expression of proosteoclastogenic cytokines mcp1 and rankl in bone and marrow respectively in male iKOs compared to male controls. Expression levels of these genes were not significantly altered in the Atg12 iKO females compared to females controls. Microcomputed tomography of tibiae revealed decreased cortical bone volume, cortical

  19. Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy.

    Science.gov (United States)

    Hamer, Isabelle; Goffin, Emeline; De Bolle, Xavier; Letesson, Jean-Jacques; Jadot, Michel

    2014-09-02

    Several intracellular bacterial pathogens have evolved subtle strategies to subvert vesicular trafficking pathways of their host cells to avoid killing and to replicate inside the cells. Brucellae are Gram-negative facultative intracellular bacteria that are responsible for brucellosis, a worldwide extended chronic zoonosis. Following invasion, Brucella abortus is found in a vacuole that interacts first with various endosomal compartments and then with endoplasmic reticulum sub-compartments. Brucella establishes its replication niche in ER-derived vesicles. In the past, it has been proposed that B. abortus passed through the macroautophagy pathway before reaching its niche of replication. However, recent experiments provided evidence that the classical macroautophagy pathway was not involved in the intracellular trafficking and the replication of B. abortus in bone marrow-derived macrophages and in HeLa cells. In contrast, another study showed that macroautophagy favoured the survival and the replication of Brucella melitensis in infected RAW264.7 macrophages. This raises the possibility that B. abortus and B. melitensis followed different intracellular pathways before replicating. In the present work, we have addressed this issue by comparing the replication rate of B. abortus and B. melitensis in embryonic fibroblasts derived from wild-type and Atg5-/- mice, Atg5 being a core component of the canonical macroautophagic pathway. Our results indicate that both B. abortus S2308 and B. melitensis 16M strains are able to invade and replicate in Atg5-deficient fibroblasts, suggesting that the canonical Atg5-dependent macroautophagic pathway is dispensable for Brucella replication. The number of viable bacteria was even slightly higher in Atg5-/- fibroblasts than in wild-type fibroblasts. This increase could be due to a more efficient uptake or to a better survival rate of bacteria before the beginning of the replication in Atg5-deficient cells as compared to wild

  20. Directive of the Minister of Justice of 16 December 1969, Stcrt. 248 concerning the implementation of Section 83 of the Nuclear Energy Act (Civil Servants Competent for the Prosecution of Criminal Acts)

    International Nuclear Information System (INIS)

    1969-01-01

    This Directive, made in implementation of the Nuclear Energy Act, Lays down that Chief Inspectors and Regional Inspectors of the Ministry of Social Affairs and Public health are competent in respect of the prosecution of criminal acts. (NEA) [fr

  1. ENRAF Series 854 Advanced Technology Gauge (ATG) with SPU II card for Leak Detector Use Acceptance Test Procedure

    International Nuclear Information System (INIS)

    SMITH, S.G.

    1999-01-01

    The following Acceptance Test Procedure was written to test the ENRAF series 854 ATG with SPU II card prior to installation in the Tank Farms. The procedure sets various parameters and verifies the gauge and alarms functionality

  2. ENRAF Series 854 Advanced Technology Gauge (ATG) with SPU ll Card for Leak Detector Use Acceptance Test Procedure

    International Nuclear Information System (INIS)

    SMITH, S.G.

    1999-01-01

    The following Acceptance Test Procedure was written to test the Enraf Series 854 ATG with SPU-II card prior to installation in the Tank Farms. The procedure sets various parameters and verifies the gauge and the alarms functionality

  3. The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos.

    Science.gov (United States)

    Kuhn, Hallie; Sopko, Richelle; Coughlin, Margaret; Perrimon, Norbert; Mitchison, Tim

    2015-11-15

    Yolk provides an important source of nutrients during the early development of oviparous organisms. It is composed mainly of vitellogenin proteins packed into membrane-bound compartments called yolk platelets. Catabolism of yolk is initiated by acidification of the yolk platelet, leading to the activation of Cathepsin-like proteinases, but it is unknown how this process is triggered. Yolk catabolism initiates at cellularization in Drosophila melanogaster embryos. Using maternal shRNA technology we found that yolk catabolism depends on the Tor pathway and on the autophagy-initiating kinase Atg1. Whereas Atg1 was required for a burst of spatially regulated autophagy during late cellularization, autophagy was not required for initiating yolk catabolism. We propose that the conserved Tor metabolic sensing pathway regulates yolk catabolism, similar to Tor-dependent metabolic regulation on the lysosome. © 2015. Published by The Company of Biologists Ltd.

  4. Identification of breast cancer cell subtypes sensitive to ATG4B inhibition

    OpenAIRE

    Bortnik, Svetlana; Choutka, Courtney; Horlings, Hugo M.; Leung, Samuel; Baker, Jennifer H.; Lebovitz, Chandra; Dragowska, Wieslawa H.; Go, Nancy E.; Bally, Marcel B.; Minchinton, Andrew I.; Gelmon, Karen A.; Gorski, Sharon M.

    2016-01-01

    Autophagy, a lysosome-mediated degradation and recycling process, functions in advanced malignancies to promote cancer cell survival and contribute to cancer progression and drug resistance. While various autophagy inhibition strategies are under investigation for cancer treatment, corresponding patient selection criteria for these autophagy inhibitors need to be developed. Due to its central roles in the autophagy process, the cysteine protease ATG4B is one of the autophagy proteins being pu...

  5. The Atomic Energy Act: Looking back on its 30 years of existence, and on its contribution to environmental protection

    International Nuclear Information System (INIS)

    Wagner, H.

    1989-01-01

    The author gives an account of the developments and the efficiency in practice of the Atomic Energy Act since its coming into effect thirty years ago. Referring to the full name of the 'Act on the peaceful uses of atomic energy and protection against its hazards', the author reviews the practical impact of this legal instrument with respect to its purpose and intent, and with respect to the developments in terms of substantive law. The article also summarizes and briefly comments proposals for amendment of the atomic energy law in the light of the 30 years of experience. (orig.) [de

  6. Saturated fatty acid palmitate negatively regulates autophagy by promoting ATG5 protein degradation in meniscus cells.

    Science.gov (United States)

    Mallik, Aritra; Yammani, Raghunatha R

    2018-07-20

    Obesity and associated metabolic factors are major risk factors for the development of osteoarthritis. Previously, we have shown that the free fatty acid palmitate induces endoplasmic reticulum (ER) stress and induces apoptosis in meniscus cells. However, the molecular mechanisms involved in these effects are not clearly understood. In our current study, we found that palmitate inhibits autophagy by modulating the protein levels of autophagy-related genes-5 (ATG5) that is associated with decreased lipidation of LC3 and increased activation of cleaved caspase 3. Pretreatment of meniscus cells with 4-phenyl butyric acid, a small molecule chemical chaperone that alleviates ER stress, or with MG-132, a proteasome inhibitor, restored normal levels of ATG5 and autophagosome formation, and decreased expression of cleaved caspase 3. Thus, our data suggest that palmitate downregulates autophagy in meniscus cells by degrading ATG5 protein via ER-associated protein degradation, and thus promotes apoptosis. This is the first study to demonstrate that palmitate-induced endoplasmic reticulum stress negatively regulates autophagy. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  7. Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

    Science.gov (United States)

    Xie, Cuicui; Ginet, Vanessa; Sun, Yanyan; Koike, Masato; Zhou, Kai; Li, Tao; Li, Hongfu; Li, Qian; Wang, Xiaoyang; Uchiyama, Yasuo; Truttmann, Anita C.; Kroemer, Guido; Puyal, Julien; Blomgren, Klas; Zhu, Changlian

    2016-01-01

    ABSTRACT Perinatal asphyxia induces neuronal cell death and brain injury, and is often associated with irreversible neurological deficits in children. There is an urgent need to elucidate the neuronal death mechanisms occurring after neonatal hypoxia-ischemia (HI). We here investigated the selective neuronal deletion of the Atg7 (autophagy related 7) gene on neuronal cell death and brain injury in a mouse model of severe neonatal hypoxia-ischemia. Neuronal deletion of Atg7 prevented HI-induced autophagy, resulted in 42% decrease of tissue loss compared to wild-type mice after the insult, and reduced cell death in multiple brain regions, including apoptosis, as shown by decreased caspase-dependent and -independent cell death. Moreover, we investigated the lentiform nucleus of human newborns who died after severe perinatal asphyxia and found increased neuronal autophagy after severe hypoxic-ischemic encephalopathy compared to control uninjured brains, as indicated by the numbers of MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3)-, LAMP1 (lysosomal-associated membrane protein 1)-, and CTSD (cathepsin D)-positive cells. These findings reveal that selective neuronal deletion of Atg7 is strongly protective against neuronal death and overall brain injury occurring after HI and suggest that inhibition of HI-enhanced autophagy should be considered as a potential therapeutic target for the treatment of human newborns developing severe hypoxic-ischemic encephalopathy. PMID:26727396

  8. Act of 21 February 1963, Stb. 82, concerning the release of nuclear energy and the use of radioactive materials and of devices emitting ionizing radiations (Nuclear Energy Act) as amended by the Act of 30 June 1967, Stb. 337, and the Act of 8 May 1974, Stb. 291

    International Nuclear Information System (INIS)

    1963-01-01

    This basic Act governs all nuclear activities in the Netherlands and determines the Government's competence and the obligations of those involved in the nuclear field. It establishes definitions and sets up bodies to advise the Government in the different nuclear sectors and covers nuclear installations, fissionable materials, ores, radioactive materials, radiation-emitting devices and their licensing. It was brought into force progressively by decrees made in implementation of its provisions, which lay down detailed regulations for the activity concerned. The chapters of the Act not yet in force were brought into operation on 1 January 1970 by the Nuclear Energy Act (Implantation) Decree of 12 November 1969. (NEA) [fr

  9. The Brussels Nuclear Ship Convention and its impact on the German Atomic Energy Act

    International Nuclear Information System (INIS)

    Bernaerts, A.

    1976-01-01

    Although the Brussels Nuclear Ship Liability Convention of 1962, whose incorporation into German law was agreed upon by the German Federal Parliament (the Bundestag) in 1975, will have only minor international significance once it has entered into force, it will yet provide a new legal basis for the nuclear liability of the German vessel N.S. 'Otto Hahn' for the periods of her stay within the Federal Republic of Germany. However, there is no smooth concurrence of the Brussels Convention and the German Atomic Energy Act adapted to the Paris Liability Convention in 1975. This means that a number of questions still need to be resolved with respect to the protection of victims and the liability of shipowners. (orig.) [de

  10. Atomic energy act, 2008: Acts supplement no. 12 to the Uganda gazette no. 61 volume CI dated 5th December, 2008

    International Nuclear Information System (INIS)

    2008-01-01

    The Act regulates peaceful application of ionising radiation, establishes the Atomic Energy Council, it provides for the protection and safety of individuals, society and the environment from dangers resulting from ionising radiation; for the production use of radiation sources and the management of radioactive wastes. It also provides for a framework for the promotion and development of nuclear energy for use in power generation and other peaceful purposes. It sets requirements for compliance with international safety and for the use of ionising radiation, radiation protection, and security of radioactive sources.

  11. ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice.

    Science.gov (United States)

    Kurdi, Ammar; Cleenewerck, Matthias; Vangestel, Christel; Lyssens, Sophie; Declercq, Wim; Timmermans, Jean-Pierre; Stroobants, Sigrid; Augustyns, Koen; De Meyer, Guido R Y; Van Der Veken, Pieter; Martinet, Wim

    2017-08-15

    Autophagy is a cell survival mechanism hijacked by advanced tumors to endure a rough microenvironment. Late autophagy inhibitors such as (hydroxy)chloroquine have been used clinically to halt tumor progression with modest success. However, given the toxic nature of these compounds and their lack of specificity, novel targets should be considered. We recently identified a benzotropolone derivative that significantly inhibited the essential autophagy protein ATG4B. Therefore, we synthesized and tested additional benzotropolone compounds to identify a promising ATG4B inhibitor that impairs autophagy both in vitro and in vivo. A compound library containing 27 molecules with a benzotropolone backbone was synthesized and screened for inhibition of recombinant ATG4B. Depending on the benzotropolone compound, inhibition of recombinant ATG4B ranged from 3 to 82%. Active compounds were evaluated in cellular assays to confirm inhibition of ATG4B and suppression of autophagy. Seven compounds inhibited processing of the autophagy protein LC3 and autophagosome formation. Compound UAMC-2526 was selected for further in vivo use because of its fair plasma stability. This compound abolished autophagy both in nutrient-deprived GFP-LC3 mice and in CD1 -/- Foxn1nu mice bearing HT29 colorectal tumor xenografts. Moreover, addition of UAMC-2526 to the chemotherapy drug oxaliplatin significantly improved inhibition of tumor growth. Our data indicate that suppression of autophagy via ATG4B inhibition is a feasible strategy to augment existing chemotherapy efficacy and to halt tumor progression. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Resorting to the Federal Constitutional Court against the atomic energy act consequences of events in Japan

    International Nuclear Information System (INIS)

    Schneider, Horst

    2011-01-01

    When the CDU/CSU-FDP coalition, which had won the federal elections, prepared the amendment to the Atomic Energy Act as announced in the election campaign, i.e. extend the operating life of nuclear power plants in Germany, the political opposition considered resorting to the Federal Constitutional Court. Several legal opinions were commissioned by federal states and other opposition groups with the intention, above all, to obtain confirmation of the need for consent to any plant life extension. Private persons filed complaints for unconstitutionality against the amendment to the Atomic Energy Act. Several federal states followed suit by filing proceedings for judicial review of the constitutionality of the amendment because of the missing consent of the Federal Council, and more than 210 Members of Parliament of SPD and Alliance 90/the Greens filed for judicial review of constitutionality listing as violations of the Constitution the missing approval by the Federal Council, insufficient safety standards, and the reduction of safety requirements. The Federal Constitutional Court has not yet continued proceedings by requesting comments mainly from the federal government, the federal states, and the nuclear power plant operators. What consequences, if any, are drawn from the events in Japan after the earthquake and the tsunami of March 11, 2011 for the operation of German nuclear power plants and worldwide cannot yet be assessed. In Germany, the anti-nuclear debate was triggered immediately in the absence of any exact knowledge of technical safety events and causes at the Fukushima nuclear power plant. International reactions in politics or by competent authorities turned out to be less pointed than in Germany. (orig.)

  13. Molecular cloning and characterization of autophagy-related gene TmATG8 in Listeria-invaded hemocytes of Tenebrio molitor.

    Science.gov (United States)

    Tindwa, Hamisi; Jo, Yong Hun; Patnaik, Bharat Bhusan; Lee, Yong Seok; Kang, Sang Sun; Han, Yeon Soo

    2015-07-01

    Macroautophagy (hereinafter called autophagy) is a highly regulated process used by eukaryotic cells to digest portions of the cytoplasm that remodels and recycles nutrients and disposes of unwanted cytoplasmic constituents. Currently 36 autophagy-related genes (ATG) and their homologs have been characterized in yeast and higher eukaryotes, including insects. In the present study, we identified and functionally characterized the immune function of an ATG8 homolog in a coleopteran insect, Tenebrio molitor (TmATG8). The cDNA of TmATG8 comprises of an ORF of 363 bp that encodes a protein of 120 amino acid residues. TmATG8 transcripts are detected in all the developmental stages analyzed. TmAtg8 protein contains a highly conserved C-terminal glycine residue (Gly116) and shows high amino acid sequence identity (98%) to its Tribolium castaneum homolog, TcAtg8. Loss of function of TmATG8 by RNAi led to a significant increase in the mortality rates of T. molitor larvae against Listeria monocytogenes. Unlike dsEGFP-treated control larvae, TmATG8-silenced larvae failed to turn-on autophagy in hemocytes after injection with L. monocytogenes. These data suggest that TmATG8 play a role in mediating autophagy-based clearance of Listeria in T. molitor. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Autophagy-Associated Protein SmATG12 Is Required for Fruiting-Body Formation in the Filamentous Ascomycete Sordaria macrospora.

    Science.gov (United States)

    Werner, Antonia; Herzog, Britta; Frey, Stefan; Pöggeler, Stefanie

    2016-01-01

    In filamentous fungi, autophagy functions as a catabolic mechanism to overcome starvation and to control diverse developmental processes under normal nutritional conditions. Autophagy involves the formation of double-membrane vesicles, termed autophagosomes that engulf cellular components and bring about their degradation via fusion with vacuoles. Two ubiquitin-like (UBL) conjugation systems are essential for the expansion of the autophagosomal membrane: the UBL protein ATG8 is conjugated to the lipid phosphatidylethanolamine and the UBL protein ATG12 is coupled to ATG5. We recently showed that in the homothallic ascomycete Sordaria macrospora autophagy-related genes encoding components of the conjugation systems are required for fruiting-body development and/or are essential for viability. In the present work, we cloned and characterized the S. macrospora (Sm)atg12 gene. Two-hybrid analysis revealed that SmATG12 can interact with SmATG7 and SmATG3. To examine its role in S. macrospora, we replaced the open reading frame of Smatg12 with a hygromycin resistance cassette and generated a homokaryotic ΔSmatg12 knockout strain, which displayed slower vegetative growth under nutrient starvation conditions and was unable to form fruiting bodies. In the hyphae of S. macrospora EGFP-labeled SmATG12 was detected in the cytoplasm and as punctate structures presumed to be phagophores or phagophore assembly sites. Delivery of EGFP-labelled SmATG8 to the vacuole was entirely dependent on SmATG12.

  15. Open road to control of constitutionality of section 7 of the Atomic Energy Act

    International Nuclear Information System (INIS)

    Rengeling, H.W.

    1978-01-01

    The Federal Constitutional Court (BVerfG), in answer to the court order of the Higher Administrative Court at Muenster, has affirmed in its interim decision of Jan. 31st, 1978 the permissibility of the concrete judicial review of the constitutionality of section 7 as being correct, and thus it has accepted at the same time the responsibility for the decision as being the responsibility of the Federal Constituional Court. For practical reasons the decision is to be welcomed because it is very likely that the question of the constitutionality of section 7 of the Atomic Energy Act as far as it permits the licensing of FRBs, which has come into the open now on account of the Muenster decision, would have been referred again in the near future to the BverfG, if the court had considered Muenster's order as not permissible. From the judicial point of view, the BVerfG's grounds are of interest; the permissibility of the judicial review of the constitutionality within the framework of the Kalkar case already having been very much in dispute before the verdict. The arguments of the BVerfG, which could be of great interest for similar proceedings in the future are briefly looked at in a critical manner, because the decision made in Karlsruhe will not remain without impacts on law concerning energy and environmental protection and on relevant policies. (orig.) [de

  16. S.1305: This Act may be cited as the Conservation and Energy Efficient Investment Act of 1991, introduced in the Senate of the United States, One Hundred Second Congress, First Session, June 17, 1991

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    This bill would amend the Internal Revenue Code of 1986 to encourage consumer participation in energy efficiency, conservation and cost-effective demand-side management by excluding from gross income payments made by utilities to customers for purchasing qualified energy conservation appliances and for taking energy conservation measures. Qualified energy conservation measures are defined in the National Energy Conservation Policy Act

  17. ATG-Fresenius inhibits blood circulating cell proliferation in a dose-dependent manner: an experimental study.

    Science.gov (United States)

    Werner, I; Seitz-Merwald, I; Kiessling, A H; Kur, F; Beiras-Fernandez, A

    2014-11-01

    Antithymocyte globulin (ATG)-Fresenius (Neovii-Biotech, Graefelfing, Germany), a highly purified rabbit polyclonal antihuman T-lymphocyte immunoglobulin resulting from immunization of rabbits with the Jurkat T-lymphoblast cell line, is currently used for the prevention of acute rejection in patients receiving solid organ transplants. Our aim was to investigate the in vitro activity of ATG-Fresenius regarding the proliferation of peripheral blood mononuclear cells (PBMCs), an important mechanism of rejection after solid organ transplantation. PBMCs were isolated from 6 healthy donors. Proliferation was assayed using [(3)H] thymidine incorporation. For analysis of mitogen-stimulated proliferation, the PBMCs were incubated at 37°C with various concentrations of ATG-Fresenius in the absence/presence of 40 μg/mL phytohemagglutinin. For analysis of the mixed lymphocyte reaction, PBMCs were incubated at 37°C with various concentrations of ATG-Fresenius for 3 days. On day 3, PBMCs (stimulator cells) from allogeneic donors were incubated with 25 μg/mL mitomycin C. The responder cells (preincubated with ATG-Fresenius) were then cultured at 37°C with the stimulator cells for 6 days. Groups were compared using ANOVA and the Tukey-Kramer multiple comparison test. Preincubation of PBMCs with ATG results in concentration-dependent inhibition of phytohemagglutinin-stimulated proliferation. The effect was more pronounced after 2 and 3 days of treatment with ATG compared with 1 day. There was a concentration-dependent decrease in the mixed lymphocyte reaction-induced proliferation (up to 80%) at ATG-Fresenius concentrations as low as 0.05 to 0.5 μg/mL. No further effect on proliferation at ATG-Fresenius concentrations of 0.5 to 50 μg/mL was seen, and higher concentrations (>100 μg/mL) totally inhibited proliferation. Our in vitro results provide more evidence of the beneficial effect of ATGs in the early phase of solid organ transplantation, by reducing effector cell

  18. The 2002 amendment to the German atomic energy act concerning the phase-out of nuclear power

    International Nuclear Information System (INIS)

    Vorwerk, A.

    2002-01-01

    The phase-out of the use of nuclear power for electricity production has now been legally regulated by the 2002 Atomic Energy Act, based on the Agreement between the German Government and the energy utilities. The provisions of this Act comply with constitutional and European law, and take account of Germany's international commitments. The new 2002 Atomic Energy Act is supplemented by additional steps towards the phase-out, in particular in the area of nuclear disposal. These steps are being taken primarily within the framework of a planned national disposal plan and a procedure to be enveloped for the selection of a location for a final disposal site for radioactive wastes. The key task for the Laender authorities and the Federal Ministry for the Environment, Nature Conservation and Nuclear Safety continues to be to ensure that operators of nuclear power plants comply with a high standard of safety during the residual operating periods of their plants. (author)

  19. Impact of the safe drinking water act on energy development. Final issue paper

    International Nuclear Information System (INIS)

    Guymont, F.J.; Shore, R.; Goldberg, M.

    1977-11-01

    Energy development activities will be impacted by the Underground Injection Control Regulations that are formulated under Part C of the Safe Drinking Water Act. The thrust of Part C of the Act is to protect groundwater that now is or in the future might be used for drinking water. A new draft of the regulations, on which this analysis is based, is currently being considered. These regulations will be either another set of proposed regulations or will be interim final which means they can be enforced immediately but EPA will still entertain comments on them and modify them if necessary. There are four possible situations in which the Underground Control Regulations would not apply. They are: If the aquifer in question can be left unprotected despite the fact that its solids level is less than 10,000 mg/1; if the aquifer is oil or mineral producing; if the aquifer is located at a depth that would made recovery of drinking water uneconomical; and if the aquifer is already contaminated. However, the individual states have to demonstrate this to the satisfaction of the EPA administrator. If none of the conditions holds, construction, monitoring operating and reporting requirements will be necessary to receive a permit. The economic impact of these requirements is uncertain but could involve significant economic and time expenditures. Permits do not have to be renewed and one permit can serve for a whole field of wells. However, the permit application requires a significant amount of information and will take a considerable amount of time and expense to fill out. Solution mining operations also will incur extra expenses establishing initial water quality profiles and maintaining monitoring wells

  20. ATG-Fresenius or daclizumab induction therapy in immunologically high risk kidney recipients: a prospective randomized pilot trial.

    Science.gov (United States)

    Kim, Min Jeong; Tsinalis, Dimitrios; Franz, Stefan; Binet, Isabelle; Gürke, Lorenz; Mihatsch, Michael J; Steiger, Jürg; Thiel, Gilbert; Dickenmann, Michael

    2008-01-01

    Despite all the advantages in the immunosuppressive therapy, kidney transplantation in immunologically high risk patients remains a challenge. Ideally, an induction therapy should provide maximal graft protection, while adverse events rate and costs remain as low as possible. Immunologically high risk kidney recipients with CDC-PRA ł 25% within the last 3 years, a positive B-cell CDC-crossmatch or graft loss due to rejection within 3 years following a prior transplantation, were randomized 1:1 to receive ATG-Fresenius (ATG-F) (9 mg/kg day 0; 3 mg/kg day 1-4) or Daclizumab therapy (1 mg/kg day 0, 14, 28, 42, 56) in a pilot study. Additional immunosuppression consisted of cyclosporine, mycophenolate mofetil, and steroids. 11 patients were included in each group. The patient (90% in ATG-F; 100% in Daclizumab) and graft survival (censored for death) (100% in ATG-F; 90% in Daclizumab) and the mean creatinine concentration at 24 months (139+/-68 mol/l in ATG-F; 176+/-103 mol/l in Daclizumab) were similar in both groups. More severe graft rejections (3 vascular rejections in Daclizumab) and adverse events (5.3/patient in ATG-F; 6.7/patient in Daclizumab) were observed in the Daclizumab group. The costs for hospitalization/ day within 24 months were lower in ATG-F (2.32+/-3.51 USD vs. 12.25+/-9.75 USD; p=0.02) resulting in an average cost-difference of more than 10'435 USD /patient. In this pilot trial, both treatments were comparably successful regarding graft and patient outcome.

  1. Act no. 933 of 11 August 1960. Establishment of the National Nuclear Energy Commission

    International Nuclear Information System (INIS)

    1960-01-01

    This Act which sets up the Comitato Nazionale per l'Energia Nucleare (CNEN) abolishes at the same time the National Committee for Nuclear Research (Comitato nazionale per le ricerche nucleari). This present Act No. 933 was subsequently annulled by Act No. 1240 of 15 December 1971 with the exception of Sections 12 to 16 which remained valid. (NEA) [fr

  2. Cloning, expression analysis, and RNA interference study of a HORMA domain containing autophagy-related gene 13 (ATG13) from the coleopteran beetle, Tenebrio molitor

    Science.gov (United States)

    Lee, Jung Hee; Jo, Yong Hun; Patnaik, Bharat Bhusan; Park, Ki Beom; Tindwa, Hamisi; Seo, Gi Won; Chandrasekar, Raman; Lee, Yong Seok; Han, Yeon Soo

    2015-01-01

    Autophagy is a process that is necessary during starvation, as it replenishes metabolic precursors by eliminating damaged organelles. Autophagy is mediated by more than 35 autophagy-related (Atg) proteins that participate in the nucleation, elongation, and curving of the autophagosome membrane. In a pursuit to address the role of autophagy during development and immune resistance of the mealworm beetle, Tenebrio molitor, we screened ATG gene sequences from the whole-larva transcriptome database. We identified a homolog of ATG13 gene in T. molitor (designated as TmATG13) that comprises a cDNA of 1176 bp open reading frame (ORF) encoding a protein of 391 amino acids. Analyses of the structure-specific features of TmAtg13 showed an intrinsically disordered middle and C-terminal region that was rich in regulatory phosphorylation sites. The N-terminal Atg13 domain had a HORMA (Hop1, Rev7, and Mad2) fold containing amino acid residues conserved across the Atg13 insect orthologs. A quantitative reverse-transcription-polymerase chain reaction analysis revealed that TmATG13 was expressed ubiquitously during all developmental stages of the insect. TmATG13 mRNA expression was high in the fat body and gut of the larval and adult stages of the insect. The TmATG13 transcripts were expressed at a high level until 6 days of ovarian development, followed by a significant decline. Silencing of ATG13 transcripts in T. molitor larvae showed a reduced survivability of 39 and 38% in response to Escherichia coli and Staphylococcus aureus infection. Furthermore, the role of TmAtg13 in initiating autophagy as a part of the host cell autophagic complex of the host cells against the intracellular pathogen Listeria monocytogenes is currently under study and will be critical to unfold the structure-function relationships. PMID:26136688

  3. Autophagy-Associated Protein SmATG12 Is Required for Fruiting-Body Formation in the Filamentous Ascomycete Sordaria macrospora.

    Directory of Open Access Journals (Sweden)

    Antonia Werner

    Full Text Available In filamentous fungi, autophagy functions as a catabolic mechanism to overcome starvation and to control diverse developmental processes under normal nutritional conditions. Autophagy involves the formation of double-membrane vesicles, termed autophagosomes that engulf cellular components and bring about their degradation via fusion with vacuoles. Two ubiquitin-like (UBL conjugation systems are essential for the expansion of the autophagosomal membrane: the UBL protein ATG8 is conjugated to the lipid phosphatidylethanolamine and the UBL protein ATG12 is coupled to ATG5. We recently showed that in the homothallic ascomycete Sordaria macrospora autophagy-related genes encoding components of the conjugation systems are required for fruiting-body development and/or are essential for viability. In the present work, we cloned and characterized the S. macrospora (Smatg12 gene. Two-hybrid analysis revealed that SmATG12 can interact with SmATG7 and SmATG3. To examine its role in S. macrospora, we replaced the open reading frame of Smatg12 with a hygromycin resistance cassette and generated a homokaryotic ΔSmatg12 knockout strain, which displayed slower vegetative growth under nutrient starvation conditions and was unable to form fruiting bodies. In the hyphae of S. macrospora EGFP-labeled SmATG12 was detected in the cytoplasm and as punctate structures presumed to be phagophores or phagophore assembly sites. Delivery of EGFP-labelled SmATG8 to the vacuole was entirely dependent on SmATG12.

  4. Interactions between energy efficiency and emission trading under the 1990 Clean Air Act Amendments

    International Nuclear Information System (INIS)

    Hillsman, E.L.; Alvic, D.R.

    1994-08-01

    The 1990 Clean Air Act Amendments affect electric utilities in numerous ways. The feature that probably has received the greatest attention is the provision to let utilities trade emissions of sulfur dioxide (SO 2 ), while at the same time requiring them to reduce S0 2 emissions in 2000 by an aggregate 43%. The emission trading system was welcomed by many as a way of reducing the cost of reducing emissions, by providing greater flexibility than past approaches. This report examines some of the potential interactions between trading emissions and increasing end-use energy efficiency. The analysis focuses on emission trading in the second phase of the trading program, which begins in 2000. The aggregate effects, calculated by an emission compliance and trading model, turn out to be rather small. Aggressive improvement of end-use efficiency by all utilities might reduce allowance prices by $22/ton (1990 dollars), which is small compared to the reduction that has occurred in the estimates of future allowance prices and when compared to the roughly $400/ton price we estimate as a base case. However, the changes in the allowance market that result are large enough to affect some compliance decisions. If utilities in only a few states improve end-use efficiency aggressively, their actions may not have a large effect on the price of an allowance, but they could alter the demand for allowances and thereby the compliance decisions of utilities in other states. The analysis shows how improving electricity end-use efficiency in some states can cause smaller emission reductions in other states, relative to what would have happened without the improvements. Such a result, while not surprising given the theory behind the emission trading system, is upsetting to people who view emissions, environmental protection, and energy efficiency in moral rather than strictly economic terms

  5. A study on how to divide and recodify the atomic energy act and its related regulations

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kyung Hui; Chung, Sang Ki; Lee, Sang Soo [Hannam Univ., Taejon (Korea, Republic of); Myung, Jae Jin [Chungnam National Univ., Taejon (Korea, Republic of)

    2003-02-15

    As a part of big project named 'streamlining and optimization of nuclear safety regulatory system', this report focuses on how to divide and recodify the Atomic Energy Act and its related regulations. Follow the first chapter of preface, the second chapter shows the systemic problems of regulation of current AEA and out strategy to reform and re-systematize it. This report concludes that the regulations of the current AEA need to be divided in three parts, i.e. the presidential regulations of FWAAE, NNA and RPA and the ministerial regulation of AEA in two part, i.e. that of NNA and RPA. Then the problems of current regulations of AEA are pointed out and the alternative regulations of FWAAE and NNA are persented in the third and forth chapter respectively. In the fifth chapter RPA is persented. And finally the legal character of several nuclear safety standards is estimated. Concerning nuclear safety or technology standards, those issued by Minister of Science and Technology (MST) empowered by law or its regulation is obviously forceful as a law. But the standards made by KINS to meet the tasks entrusted to KINS by MST is only conditionally forceful as a law, that is, on the condition that law or regulation empowered the chief of KINS to make nuclear safety and/or technology standards.

  6. Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.

    Science.gov (United States)

    Ichimura, Atsuhiko; Hirasawa, Akira; Hara, Takafumi; Tsujimoto, Gozoh

    2009-09-01

    Free fatty acids (FFAs) have been demonstrated to act as ligands of several G-protein-coupled receptors (GPCRs) (FFAR1, FFAR2, FFAR3, GPR84, and GPR120). These fatty acid receptors are proposed to play critical roles in a variety of types of physiological homeostasis. FFAR1 and GPR120 are activated by medium- and long-chain FFAs. GPR84 is activated by medium-chain, but not long-chain, FFAs. In contrast, FFAR2 and FFAR3 are activated by short-chain FFAs. FFAR1 is expressed mainly in pancreatic beta-cells and mediates insulin secretion, whereas GPR120 is expressed abundantly in the intestine and promotes the secretion of glucagon-like peptide-1 (GLP-1). FFAR3 is expressed in enteroendocrine cells and regulates host energy balance through effects that are dependent upon the gut microbiota. In this review, we summarize the identification, structure, and pharmacology of these receptors and present an essential overview of the current understanding of their physiological roles.

  7. The licensing procedure under the Atomic Energy Act - an instrument out of tune

    International Nuclear Information System (INIS)

    Kraemer, H.

    1981-01-01

    While it was possible until 1970 to license and build nuclear power plants in the Federal Republic of Germany on the basis of the Atomic Energy Act subject to stringent safety criteria more or less as quickly as in other industrialized countries, the situation became much more insecure in the seventies, as a result of the use of nuclear power more and more turning into a political issue. As a consequence, the time required for licensing and building a nuclear power plant increased from formerly five to at present ten years, which has created major losses to the German economy to this day. Tese losses are composed of the interest burden, price increases, additional conditions imposed by public authorities, and costs associated with purchases of electricity from outside sources in those cases where plants were completed late. For an average size electricity utility, these losses amount to several billion deutschmarks. The increasingly longer licensing procedures and the growing number of conditions imposed during the construction period no longer reflected the provisions necessary to ensure safety and reliability of the plant, but fostered intentions to incorporate even those conditions and criteria which might one day be raised, in a stage in which there was often no clear view of further developments. In this way, technical details were finalized at an unnecessarily early date and, very often, superfluous safety margins became necessary. (orig.) [de

  8. The role and limitation of judicial control in the licensing procedure under the Atomic Energy Act

    International Nuclear Information System (INIS)

    Sommer, W.E.

    1983-01-01

    This paper discusses the problems of the judiciary with decision-finding in proceedings where large and complicated technical installations are involved, presenting proposals aiming at more clearly defining and probably restricting judicial control. According to the author, a feasible step towards limiting the controlling competence of the judiciary is to more precisely define the factual characteristic 'state of the art in science and technology' which, in pursuance with sect. 7, sub-sect. 2 of the Atomic Energy Act is taken as a criterion to evaluate the efficiency of precautionary measures to prevent damage emanating from the erection and operation of nuclear installations. As the legislature explicitly wants the judiciary to use this characteristic, the judiciary has to have recourse to evaluation factors that do not belong to the science of jurisprudence. It is not the function of the judiciary to verify whether the 'state of the art' is based on appropriate principles. This adoption guarantees the 'best possible risk prevention and protection against hazards', as required by the Federal Constitutional Court. (orig./HSCH) [de

  9. The effects of the German renewable energy sources Act (EEG) on market, technical and industrial development

    International Nuclear Information System (INIS)

    Stryi-Hipp, G.

    2004-01-01

    Since 1999, the German photovoltaic market has been growing rapidly. In 2003, more than 130 MWp PV systems were installed in Germany; in 2004, more than 200 MWp are expected to be installed additionally. The main reason for this impressive market success has been the market stimulation policy of the German government. In January 1999, the 100.000 Roofs Programme for photovoltaic systems had started, offering interest-reduced loans for PV systems. In April 2000, it was backed by the Renewable Energy Sources Act (EEG), which considerably increased the feed-in tariff to 99 Pfennig (0.51 euros) per kWh. Since then, the PV market has boomed. In 2003, the 100,000 Roofs Programme (HTRP) ended successfully, after loans for more than 300 MWp PV systems had been granted. In order to fill the gap created by the termination of the programme, the government decided to increase the feed-in tariff provided by the EEG. Since January 2004, grid-connected PV systems on roofs and facades receive a tariff between 0,540 euros and 0,624 euros per kWh over 20 years. This improvement of the EEG further increased the interest in photovoltaics. The growth rate of the photovoltaic market, exceeding 50% in 2004, has led to the demand being higher than the available supply of PV systems. (author)

  10. Air toxics provisions of the Clean Air Act: Potential impacts on energy

    International Nuclear Information System (INIS)

    Hootman, H.A.; Vernet, J.E.

    1991-11-01

    This report provides an overview of the provisions of the Clean Air Act and its Amendments of 1990 that identify hazardous air pollutant (HAP) emissions and addresses their regulation by the US Environmental Protection Agency (EPA). It defines the major energy sector sources of these HAPs that would be affected by the regulations. Attention is focused on regulations that would cover coke oven emissions; chromium emission from industrial cooling towers and the electroplating process; HAP emissions from tank vessels, asbestos-related activities, organic solvent use, and ethylene oxide sterilization; and emissions of air toxics from municipal waste combustors. The possible implications of Title III regulations for the coal, natural gas, petroleum, uranium, and electric utility industries are examined. The report discusses five major databases of HAP emissions: (1) TRI (EPA's Toxic Release Inventory); (2) PISCES (Power Plant Integrated Systems: Chemical Emissions Studies developed by the Electric Power Research Institute); (3) 1985 Emissions Inventory on volatile organic compounds (used for the National Acid Precipitation Assessment Program); (4) Particulate Matter Species Manual (EPA); and (5) Toxics Emission Inventory (National Aeronautics and Space Administration). It also offers information on emission control technologies for municipal waste combustors

  11. Association of ATG16L1 gene haplotype with inflammatory bowel disease in Indians.

    Directory of Open Access Journals (Sweden)

    Srinivasan Pugazhendhi

    Full Text Available Inflammatory bowel disease (IBD is characterized by multigenic inheritance. Defects in autophagy related genes are considered to show genetic heterogeneity between populations. We evaluated the association of several single nucleotide polymorphisms (SNPs in the autophagy related 16 like 1 (ATG16L1 gene with IBD in Indians. The ATG16L1 gene was genotyped for ten different SNPs using DNA extracted from peripheral blood of 234 patients with Crohn's disease (CD, 249 patients with ulcerative colitis (UC and 393 healthy controls The SNPs rs2241880, rs4663396, rs3792106, rs10210302, rs3792109, rs2241877, rs6737398, rs11682898, rs4663402 and rs4663421 were genotyped using the Sequenom MassArray platform. PLINK was used for the association analysis and pairwise linkage disequilibrium (LD values. Haplotype analysis was done using Haploview. All SNPs were in Hardy Weinberg equilibrium in cases and controls. The G allele at rs6737398 exhibited a protective association with both CD and UC. The T allele at rs4663402 and C allele at rs4663421 were positively associated with CD and UC. The T allele at rs2241877 exhibited protective association with UC only. The AA genotype at rs4663402 and the GG genotype at rs4663421 were protectively associated with both CD and UC. Haplotype analysis revealed that all the SNPs in tight LD (D' = 0.76-1.0 and organized in a single haplotype block. Haplotype D was positively associated with IBD (P = 5.8 x 10-6 for CD and 0.002 for UC. SNPs in ATG16L1 were associated with IBD in Indian patients. The relevance to management of individual patients requires further study.

  12. Has the Federal Government the power to instruct State authorities in procedures under the Atomic Energy Act

    International Nuclear Information System (INIS)

    Ost, W.; Pelzer, N.

    1979-01-01

    The differences in opinion which have emerged between the Federal Government and ministers of the State of North Rhine-Westphalia about further permits to be issued for construction of the SNR 300 fast breeder reactor at Kalkar have raised the question of whether the Federal Government has the right to issue directives to a state authority to grant a permit. Close examination of the legal aspects indicates that hardly any literature and no court decisions are as yet available on this problem, because it has never played a role so far. However, it is undisputed that there is such a right to give instructions. Under the Constitution and the Atomic Energy Act the state authorities are responsible for granting permits, but only as agents acting on behalf of the federal authority. Such instructions must be in accordance with the Atomic Energy Act and the objective sought must be lawful for the instructions to be effective. (orig.) [de

  13. ATG-Fresenius S combined with cyclosporine a: an effective immunosuppressive therapy for children with aplastic anemia.

    Science.gov (United States)

    Luo, Cheng-Juan; Gao, Yi-Jin; Tang, Jing-Yan; Zhu, Xiao-Hua; Xue, Hui-Liang; Lu, Feng-Juan; Pan, Ci; Jiang, Hua; Luo, Chang-Ying; Ye, Qi-Dong; Zhou, Min; Chen, Jing

    2014-07-01

    For the first time, we conducted a 2-center retrospective study to show the efficacy of antithymocyte globulin (ATG)-Fresenius S plus cyclosporine treatment of children with severe aplastic anemia. From March 1997 to May 2011, a total of 124 patients (median age, 7.5 y; range, 1.5 to 16 y) from 2 centers with acquired AA treated with an immunosuppressive therapy (IST) regimen, consisting of ATG-Fresenius S (5 mg/kg per day for 5 d) and cyclosporine, were enrolled. The response rate was 55.6%. The median time between IST and response was 6 (0.5 to 18) months. After a median follow-up time of 29 (6 to 153) months, the rates of relapse and clonal evolution were 3.2% and 0.8%, respectively. Overall, 17 patients (13.7%) died in this study: 14 resulted from sepsis, 1 resulted from intracranial hemorrhage, 1 occurred after hematopoietic stem cell transplantation, and 1 resulted from clonal disease progression. The 5-year overall survival rate for the entire cohort was 74.7%. IST responders had a better survival rate (100%) than nonresponders (70.7%). The use of ATG-Fresenius S plus cyclosporine as a first-line immunosuppressive treatment appeared to be effective for children with severe aplastic anemia in our study. ATG-Fresenius S could be another option in the treatment arsenal, especially in countries where the other ATG products are harder to acquire.

  14. Protection of business and industrial secrets under the Atomic Energy Act and the relevant ordinances governing licensing and supervisory procedures

    International Nuclear Information System (INIS)

    Steinberg, R.

    1988-01-01

    The article deals with problems concerning the protection of secret information in licensing and supervisory procedures under the Atomic Energy Act and the relevant ordinances. The extent of the secret protection of business and industrial secrets is regulated differently for both procedures. These legal provisions have to be interpreted with due consideration for third party interests in information. (WG) [de

  15. Federal energy conservation programs pursuant to section 381 of the Energy Policy and Conservation Act (Public Law 94-163). Annual report to Congress

    Energy Technology Data Exchange (ETDEWEB)

    1979-02-21

    This report provides an overview of the activities and achievements of the executive branch of the Federal Government in implementing the energy conservation requirements and provisions of section 381 of the Energy Policy and Conservation Act (EPCA) of 1975 (Public Law 94-163). The report describes Federal actions to develop procurement policies that promote energy conservation and efficiency, develop a Federal 10-Year Buildings Energy Conservation Plan, develop responsible public education and information programs, encourage energy conservation and energy efficiency, and promote vanpooling and carpooling arrangements. About half of the Nation's energy is used in our homes and automobiles. Another 48 percent is used by State and local governments, business and insutry, in providing needed goods and services. The Federal Government is the Nation's largest energy user, accouting for 2.2 percent of the total national energy used in 1977. This energy is used by nearly 6 million people in more than 400 thousand buildings and in the operation of more than 600 thousand vehicles. While energy conservation and energy efficiency measures alone cannot solve our immediate problems, they are an essential part of our transition to an era of scarce and expensive energy supplies.

  16. The Ca{sup 2+} channel TRPML3 specifically interacts with the mammalian ATG8 homologue GATE16 to regulate autophagy

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Suzy; Kim, Hyun Jin, E-mail: kimhyunjin@skku.edu

    2014-01-03

    Highlights: •Split-ubiquitin MY2H screen identified GATE16 as an interacting protein of TRPML3. •TRPML3 specifically binds to a mammalian ATG8 homologue GATE16, not to LC3B. •The interaction of TRPML3 with GATE16 facilitates autophagosome formation. •GATE16 is expressed in both autophagosome and extra-autophagosomal compartments. -- Abstract: TRPML3 is a Ca{sup 2+} permeable cation channel expressed in multiple intracellular compartments. Although TRPML3 is implicated in autophagy, how TRPML3 can regulate autophagy is not understood. To search interacting proteins with TRPML3 in autophagy, we performed split-ubiquitin membrane yeast two-hybrid (MY2H) screening with TRPML3-loop as a bait and identified GATE16, a mammalian ATG8 homologue. GST pull-down assay revealed that TRPML3 and TRPML3-loop specifically bind to GATE16, not to LC3B. Co-immunoprecipitation (co-IP) experiments showed that TRPML3 and TRPML3-loop pull down only the lipidated form of GATE16, indicating that the interaction occurs exclusively at the organellar membrane. The interaction of TRPML3 with GATE16 and GATE16-positive vesicle formation were increased in starvation induced autophagy, suggesting that the interaction facilitates the function of GATE16 in autophagosome formation. However, GATE16 was not required for TRPML3 trafficking to autophagosomes. Experiments using dominant-negative (DN) TRPML3(D458K) showed that GATE16 is localized not only in autophagosomes but also in extra-autophagosomal compartments, by contrast with LC3B. Since GATE16 acts at a later stage of the autophagosome biogenesis, our results suggest that TRPML3 plays a role in autophagosome maturation through the interaction with GATE16, by providing Ca{sup 2+} in the fusion process.

  17. Health impact assessment of Ontario's green energy and green economy act. The roles of environmental informatics in sustainability

    International Nuclear Information System (INIS)

    Rattle, Robert

    2013-01-01

    Renewable energy received a boost in Ontario, Canada with the Green Energy and Green Economy Act (GEGEA), ushering in a new Feed-in-Tariff (FIT) program modelled on programs from Germany, Spain, Denmark and other jurisdictions. Information about lessons learned elsewhere has clearly benefited the Ontario experience. Part of the Ontario program included streamlining the impact assessment process to facilitate the swift development of provincial renewable energy capacities. In this context, the GEGEA has been remarkably successful, generating renewable energy sector capacities, resources, projects and their spin-off benefits in Ontario, along with more sustainable electricity system. Environmentalists along with industry continue to laud the benefits of renewable energy and the GEGEA, and with good reason. Renewable energy generation in Ontario has grown from to 2 per cent in 2012 and is expected to reach 10 per cent in 2013. (orig.)

  18. Act No. 18/1997 of 24 January 1997 on peaceful uses of nuclear energy and ionizing radiation (Atomic Act) and on the amendment of some laws

    International Nuclear Information System (INIS)

    1997-01-01

    This Act is the fundamental law governing the peaceful uses of nuclear energy and ionizing radiation in the Czech Republic, superseding all the previous Czech laws dealing with the partial segments of this field. The following topics are covered: (a) ways of using nuclear energy and ionizing radiation and requirements for activities associated with the use of nuclear energy and activities resulting in irradiation; (b) the system of protection of persons and the environment from adverse effects of ionizing radiation; (c) responsibilities in connection with the development and implementation of provisions to reduce natural irradiation and irradiation due to radiation accidents; (d) special requirements to ensure liability for nuclear damage; (e) conditions and requirements for a safe radioactive waste management; and (f) national regulatory responsibilities and activities with respect to the use of nuclear energy and activities resulting in irradiation, and to the supervision of nuclear items. This concerns particularly the State Office for Nuclear Safety as the national regulatory body. (P.A.)

  19. Using microbes as a key tool to unravel the mechanism of autophagy and the functions of the ATG proteins

    Directory of Open Access Journals (Sweden)

    Mario Mauthe

    2016-12-01

    Full Text Available The study of microbe infections has always been a very effective approach to unveil and dissect cellular pathways. Autophagy is not an exception. Although some of the breakthrough discoveries in the field were obtained using yeast, pathogens have been and still are a great tool to discover and characterize new molecular and functional aspects of autophagy. Research on pathogens has helped to acquire knowledge about selective types of autophagy and the assembly of the autophagy machinery, i.e the autophagy-related (ATG proteins, but also about alternative cellular roles of this pathway, such as secretion. Finally, microbes have also served to discover and characterize unconventional functions of the ATG proteins, which are uncoupled from their role in autophagy. In our recent study, we have taken advantage of viruses as a screening tool to determine the extent of the unconventional functions of the ATG proteome and characterize one of them.

  20. Defining energy vulnerability in mobility. Measuring energy vulnerability in mobility. Acting against energy vulnerability in mobility. Discussing energy vulnerability in mobility. Task no. 4

    International Nuclear Information System (INIS)

    Jouffe, Yves; Massot, Marie-Helene; Noble, Cyprien

    2015-01-01

    Extensive expansion of urban areas generates transportation needs and energy expenses for mobility. Households already impacted by fuel poverty also suffer from energy vulnerability in their mobility. This report was prepared in the framework of the study of fuel poverty in France in the light of several indicators from existing inquiries, databases and modeling tools. The report is organised in 4 parts dealing with: the definition of energy vulnerability in mobility, its measurement, the possible remedial actions, and the discussions about energy vulnerability in mobility through working group meetings, respectively

  1. To act in concrete terms for energy transition - The ATEE details its proposals

    International Nuclear Information System (INIS)

    2013-01-01

    The ATEE (Association Technique Energie Environnement) is a professional association which herein formulates eighteen proposals to support and promote energy transition. Before presenting these proposals, the report identifies and discusses two main axis of action: energy efficiency and saving (promotion of energetic renewal of existing buildings, promotion of energy management practices in companies, promotion of co-generation with natural gas) and renewable energies and energy storage (development of the biogas sector, create the conditions for the development of energy storage systems)

  2. Intraoperative anti-thymocyte globulin-Fresenius (ATG-F) administration as induction immunosuppressive therapy in kidney transplantation.

    Science.gov (United States)

    Abou-Jaoude, Maroun M; Almawi, Wassim Y

    2003-07-01

    We reviewed 43 adult kidney transplant patients (32 males and 11 females, 14-68 years of age) performed at our center between July 1999 and February 2002. Donors (39 males and 4 females) comprised two cadaverics, five living-related and 36 living-unrelated; age 18-44 years. Indications for kidney transplantation (KT) were: chronic glomerulonephritis (8), re-transplantation (4) and chronic pyelonephritis (3); kidney disease was unknown in 15 cases. ATG-F was given as a single intra-operative bolus induction therapy in 26 patients; extended ATG-F dose was given in 17 patients because of a high sensitization status, slow graft function (SGF) or development of calcineurin inhibitors toxicity. ATG-F was stopped in seven out of 17 patients because of thrombocytopenia or severe anemia. ATG-F-related fever occurred in six patients. Acute rejection (AR) occurred in eight patients (18%) 5-11 days post-KT. ATG-F was given in three steroid-resistant AR. Infection occurred in 19 patients (44%) for a total of 32 infectious episodes comprising 24 bacterial infections (nine urinary, seven catheter-related and three respiratory), six viral infections (five CMV and one herpes) and two fungal infections (one pulmonary aspergillosis and one catheter-related candidiasis). The hospital stay was 8-75 days for a median of 13 days. The mean serum creatinine upon discharge, at 1 and 6 months after KT were: 2.04+/-0.37, 1.43+/-0.16 and 1.29+/-0.08, respectively. One patient lost his graft on day 9 because of graft microthrombi related to Factor V-Leiden mutation. The 6 months actuarial patient and graft survival were 100 and 97.6%, respectively. ATG-F as a bolus therapy is an effective and safe induction treatment in KT.

  3. Let-7i-Induced Atg4B Suppression Is Essential for Autophagy of Placental Trophoblast in Preeclampsia.

    Science.gov (United States)

    Xu, Yinyan; Huang, Xinyan; Xie, Juan; Chen, Yanni; Fu, Jing; Wang, Li

    2017-09-01

    Autophagy, identified as type II programmed cell death, has already been known to be involved in the pathophysiology of preeclampsia (PE), which is a gestational disease with high morbidity. The present study aims to investigate the functional role of let-7i, a miRNA, in trophoblastic autophagy. Placental tissue used in this study was collected from patients with severe preeclampsia (SPE) or normal pregnant women. A decreased level of let-7i was found in placenta of SPE. In addition, autophagic vacuoles were observed in SPE and the expression of microtubule associated protein 1 light chain 3 (LC3) II/I was elevated. In vitro, let-7i mimics suppressed the autophagic activities in human HTR-8/SVneo trophoblast cell line (HTR-8) and human placental choriocarcinoma cell line JEG-3, whereas let-7i inhibitor enhanced the activities. As a potential target of let-7i, autophagy-related 4B cysteine peptidase (Atg4B) had an increased expression level in SPE. As expected, the increased expression of Atg4B was negatively regulated by let-7i using dual luciferase reporter assay. Furthermore, these trophoblast-like cells transfected with the let-7i mimic or inhibitors resulted in a significant change of Atg4B in both mRNA and protein level. More importantly, Atg4B overexpression could partly reverse let-7i mimic-reduced LC3II/I levels; whereas Atg4B silencing partly attenuated let-7i inhibitor-induced the level of LC3II/I expression. Taken together, these findings suggest that let-7i is able to regulate autophagic activity via regulating Atg4B expression, which might contribute to the pathogenesis of PE. J. Cell. Physiol. 232: 2581-2589, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  4. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5.

    Science.gov (United States)

    Nezich, Catherine L; Wang, Chunxin; Fogel, Adam I; Youle, Richard J

    2015-08-03

    The kinase PINK1 and ubiquitin ligase Parkin can regulate the selective elimination of damaged mitochondria through autophagy (mitophagy). Because of the demand on lysosomal function by mitophagy, we investigated a role for the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, in this process. We show that during mitophagy TFEB translocates to the nucleus and displays transcriptional activity in a PINK1- and Parkin-dependent manner. MITF and TFE3, homologues of TFEB belonging to the same microphthalmia/transcription factor E (MiT/TFE) family, are similarly regulated during mitophagy. Unlike TFEB translocation after starvation-induced mammalian target of rapamycin complex 1 inhibition, Parkin-mediated TFEB relocalization required Atg9A and Atg5 activity. However, constitutively active Rag guanosine triphosphatases prevented TFEB translocation during mitophagy, suggesting cross talk between these two MiT/TFE activation pathways. Analysis of clustered regularly interspaced short palindromic repeats-generated TFEB/MITF/TFE3/TFEC single, double, and triple knockout cell lines revealed that these proteins partly facilitate Parkin-mediated mitochondrial clearance. These results illuminate a pathway leading to MiT/TFE transcription factor activation, distinct from starvation-induced autophagy, which occurs during mitophagy.

  5. SmATG7 is required for viability in the homothallic ascomycete Sordaria macrospora.

    Science.gov (United States)

    Nolting, Nicole; Bernhards, Yasmine; Pöggeler, Stefanie

    2009-08-01

    In filamentous ascomycetes, autophagy is involved in several developmental processes. Nevertheless, until now little is known about its role in fruiting-body development. We therefore isolated a gene of the homothallic ascomycete Sordaria macrospora with high sequence similarity to the Saccharomyces cerevisiae autophagy-related gene ATG7, encoding a core autophagy regulator. This is the first characterization of an ATG7 homolog in filamentous ascomycetes. A S. cerevisiae complementation assay demonstrated that the S. macrospora Smatg7 gene functionally replaces the yeast homolog. We were not able to generate a homokaryotic knock-out mutant in S. macrospora, suggesting that Smatg7 is required for viability. However, a heterokaryotic DeltaSmatg7/Smatg7 strain and transformants generated by RNA interference showed considerable morphological phenotypes during fruiting-body development. Using real-time PCR, we demonstrated that in the wild type, the transcriptional expression of Smatg7 is markedly up-regulated under amino acid starvation conditions and at late stages during sexual development. Moreover, we showed that transcriptionally down-regulation of Smatg7 disturbs autophagy in S. macrospora.

  6. Efficacy and Safety of ATG-Fresenius as an Induction Agent in Living-Donor Kidney Transplantation.

    Science.gov (United States)

    Yilmaz, M; Sezer, T Ö; Günay, E; Solak, I; Çeltik, A; Hoşcoşkun, C; Töz, H

    2017-04-01

    Induction therapy is mostly recommended for deceased-donor transplantation, whereas it has some controversies in live-donor transplantation. In this study, we described the outcomes of live-donor renal transplant recipients who received ATG-Fresenius (ATG-F) induction. Live-donor transplantations in patients over 18 years old with ATG-F induction between 2009 and 2015 were included. All patients received quadruple immunosuppression, one of which was ATG-F induction. Biopsies after the artery anastomosis (zero hour) and protocol biopsies at the 6th month and at the 1st first year were obtained. Acute graft dysfunction was defined as a 20% to 25% increase in creatinine level from baseline. All acute rejection episodes were biopsy-confirmed. All episodes were initially treated with intravenous methyl prednisolone (MP) or ATG-F if resistant to MP. Four hundred twenty-two patients with live-donor transplantation were evaluated. The mean age was 40 ± 13 (18-73) years. The mean panel-reactive antibody levels were 42% ± 30% and 45% ± 30% for class I and II, respectively. The mean mismatch number for living unrelated donors (n = 112) was 4.6 ± 1.0. Acute rejection rate was 29.1% (123 patients) within the first year. The mean cumulative ATG-F doses for per patient and per kilogram were 344 ± 217 mg and 5.1 ± 2.7 mg, respectively. Patient survival rates were 98.3% and 96.7% for 12 months and 60 months, respectively. Death-censored graft survival rates were 97.6% and 92.1% for 12 months and 60 months, respectively. ATG-F induction provided excellent graft and patient survival rates without any significantly increased side effects. Increasing sensitized patient numbers, more unrelated donors, increasing re-transplantation numbers, and more desensitization protocols make ATG-F more favorable in an induction regimen. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Atomic Energy Authority (Special Constables) Act 1976 of 10 June 1976

    International Nuclear Information System (INIS)

    1976-01-01

    This Act, which came into force on 10th June 1976, extends the powers of the UKAEA's Special Constables (i.e. Police) so that they may be better able to safeguard fissile materials in nuclear installations and during transport. Under the Act the UKAEA's Special Constables are deemed to be Crown servants for the purposes of the Firearms Act 1968, Section 2, and it extends the kind of property in relation to which the UKAEA's Special Constables may exercise their powers when they are outside the premises within which they were appointed to act. It also extends the geographical limits within which the UKAEA's Special Constables may exercise their powers, so that their powers may now be exercised wherever they may go in order to safeguard fissile materials or to pursue persons believed to have removed or attempted to remove such materials unlawfully. (NEA) [fr

  8. Heat grids today and after the German Renewable Energies Act (EEG). A business segment for the agriculture?

    International Nuclear Information System (INIS)

    Clemens, Dietrich; Billerbeck, Hagen

    2016-01-01

    The development of a centralised and sustainable heat supply through the construction of heat grids offers consumers numerous advantages compared to a decentralised energy supply of residential and commercial properties. Where the migration to centralised heat supply relegates fossil fuels through the long-term incorporation of sustainable renewable energy sources, the projects make an important contribution towards meeting the government's climate protection goals. Heat generation and heat sales from renewable energy sources should be ensured in the long term. In the countryside, biogas plant operators are frequently the initiators of heat grid investments, or they take on the role of supplier for the provision of low-cost CHP heat from cogeneration units. In view of the limited remuneration period under the terms of the German Renewable Energy Act, the clock is ticking for the establishment of a centralised heat supply. This paper presents the advantages and disadvantages of a centralised, sustainable heat supply and additionally considers the flexibi/isation of biogas plants in view of the construction of the heat grid and the associated infrastructure. A focus is placed on the security of supply for customers after the discontinuation of remuneration under the German Renewable Energy Act and on how a competitive heat price from alternative energy sources can continue to be ensured.

  9. Constitutionality of section 7 of the Atomic Energy Act: Section 20 GG 'Kalkar decision'. [German Federal Republic

    Energy Technology Data Exchange (ETDEWEB)

    1978-06-01

    OVG Muenster, decision dated Aug. 18th, 1977 - VII A 338/74: 'Section 7 of the Atomic Energy Act disagrees with the constitution in as far as it also allows the licensing of FBR type reactores'. The grounds upon which the judgment is based are given in detail: According to the opinion of the Senate, section 7 of the Atomic Energy Act does not conform to the principle of separation of powers (section 20, sub-section 2, sentence 2 GG), to the principle of parliamentary democracy (section 20, sub-section 1 and 2 GG) and to the principles of the law and order state (section 20, sub-section 3 GG) in as far as the present version enables the licensing of fast breeders.

  10. Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study.

    Directory of Open Access Journals (Sweden)

    Monica Grafals

    Full Text Available Rabbit antithymocyte globulin (ATG is commonly used as an induction therapy in renal transplant recipients, but the ideal dosage in tacrolimus-based early steroid withdrawal protocols has not been established. The purpose of this pilot study was to determine the immunophenotyping and efficacy of lower dose ATG in low immunological-risk kidney transplant recipients. In this prospective study, 45 patients were randomized (1∶1 to our standard dose ATG (total dose 3.75 mg/kg(sATG vs. lower dose 2.25 mg/kg (lowATG. All patients underwent early steroid withdrawal within 7 days. The primary end point was biopsy-proven acute rejection at 12 months. Prospective immunophenotyping of freshly isolated PBMCs was performed at baseline, 3, 6, 12 months post-transplant. The rate of acute rejection was 17% and 10% in the sATG and lowATG, respectively. Effector memory T cells, Tregs and recent thymic emigrants T cells had similar kinetics post-transplant in both groups. No statistically significant differences were found in graft survival, patient survival or infections between the two groups, though there was a non-significant increase in leukopenia (43%v s. 30%, CMV (8% vs. 0 and BK (4% vs. 0 infections in sATG group vs. lowATG. In sum, in low immunological risk kidney recipients undergoing steroid withdrawal, low dose ATG seems to be efficacious in preventing acute rejection and depleting T cells with potentially lower infectious complications. A larger study is warranted to confirm these findings.ClinicalTrials.gov NCT00548405.

  11. Can Culture Act as an Enabler to Innovation? Exploring the Germany-Ontario Experience Regarding the Introduction of Green Energy

    OpenAIRE

    Bill Irwin; Jan A.C. Klakurka

    2015-01-01

    This paper explores the role that societal culture may play in terms of acting as an inhibitor or enabler when creating conditions conducive to innovative enterprise. To further understanding of this concept, the paper's authors explore different cultural influences and traditions of the country of Germany and the Canadian province of Ontario against the backdrop of the introduction of a government green energy policy and how local business reacts to new opportunities forthcoming from this sh...

  12. Proximity Ligation In situ Assay is a Powerful Tool to Monitor Specific ATG Protein Interactions following Autophagy Induction.

    Directory of Open Access Journals (Sweden)

    Thierry Gauthier

    Full Text Available Macroautophagy is a highly regulated intracellular degradation process which has been extensively studied over the last decade. This pathway has been initially described as a non selective process inducing the degradation of parts of the cytoplasm as well as organelles at random. Nevertheless, over the last few years, new research highlighted the existence of a more selective autophagy pathway specifically recruiting some organelles or aggregates to the autophagosomes in order to induce their degradation. These selective autophagy pathways such as aggrephagy, mitophagy, pexophagy or xenophagy, involve the intervention of a cargo, the material to be degraded, cargo adapters, the molecules allowing the recruitment of the cargo to the autophagosome, and the proteins of the ATG8 family which link the cargo adapters to the autophagosome. One of the main questions which now remain is to develop new techniques and protocols able to discriminate between these different types of induced autophagy. In our work, we studied the possibility to use the P-LISA technique, which has been recently developed to study endogenous in vivo protein interactions, as a new technique to characterize the ATG proteins specifically involved in bulk or selective autophagy. In this manuscript, we indeed demonstrate that this technique allows the study of endogenous ATG protein interactions in cells following autophagy induction, but more interestingly that this technique might be used to characterize the ATG proteins involved in selective autophagy.

  13. Renewable and Nuclear Energy: an International Study of Students' Beliefs About, and Willingness to Act, in Relation to Two Energy Production Scenarios

    Science.gov (United States)

    Skamp, Keith; Boyes, Eddie; Stanisstreet, Martin; Rodriguez, Manuel; Malandrakis, Georgios; Fortner, Rosanne; Kilinc, Ahmet; Taylor, Neil; Chhokar, Kiran; Dua, Shweta; Ambusaidi, Abdullah; Cheong, Irene; Kim, Mijung; Yoon, Hye-Gyoung

    2017-07-01

    Renewable and nuclear energy are two plausible alternatives to fossil fuel-based energy production. This study reports students' beliefs about the usefulness of these two options in reducing global warming and their willingness to undertake actions that would encourage their uptake. Using a specially designed questionnaire, students' (n > 12,000; grades 6 to 10) responses were obtained from 11 countries. Links between their beliefs about these energy options and their willingness to act were quantified using a range of novel derived indices: significant differences between beliefs and willingness to act were found across the various counties. One derived index, the Potential Effectiveness of Education, measures the extent to which enhancing a person's belief in the effectiveness of an action might increase their willingness to undertake that action: this indicated that education may impact willingness to act in some countries more than others. Interpretations are proffered for the reported differences between countries including whether the extent of students' concern about global warming had impacted their decisions and whether cultural attributes had any influence. Pedagogical ways forward are related to the findings.

  14. Neither eosinophils nor neutrophils require ATG5-dependent autophagy for extracellular DNA trap formation.

    Science.gov (United States)

    Germic, Nina; Stojkov, Darko; Oberson, Kevin; Yousefi, Shida; Simon, Hans-Uwe

    2017-11-01

    The importance of extracellular traps (ETs) in innate immunity is well established, but the molecular mechanisms responsible for their formation remain unclear and in scientific dispute. ETs have been defined as extracellular DNA scaffolds associated with the granule proteins of eosinophils or neutrophils. They are capable of killing bacteria extracellularly. Based mainly on results with phosphoinositide 3-kinase (PI3K) inhibitors such as 3-methyladenine (3-MA) and wortmannin, which are commonly used to inhibit autophagy, several groups have reported that autophagy is required for neutrophil extracellular trap (NET) formation. We decided to investigate this apparent dependence on autophagy for ET release and generated genetically modified mice that lack, specifically in eosinophils or neutrophils, autophagy-related 5 (Atg5), a gene encoding a protein essential for autophagosome formation. Interestingly, neither eosinophils nor neutrophils from Atg5-deficient mice exhibited abnormalities in ET formation upon physiological activation or exposure to low concentrations of PMA, although we could confirm that human and mouse eosinophils and neutrophils, after pre-treatment with inhibitors of class III PI3K, show a block both in reactive oxygen species (ROS) production and in ET formation. The so-called late autophagy inhibitors bafilomycin A1 and chloroquine, on the other hand, were without effect. These data indicate that ET formation occurs independently of autophagy and that the inhibition of ROS production and ET formation in the presence of 3-MA and wortmannin is probably owing to their additional ability to block the class I PI3Ks, which are involved in signalling cascades initiated by triggers of ET formation. © 2017 John Wiley & Sons Ltd.

  15. S. 1802: This Act may be referred to as the Department of Energy Nuclear Facilities of Act of 1989. Introduced in the Senate of the United States, One Hundredth First Congress, First Session, October 26, 1989

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    This bill would enhance nuclear safety at Department of Energy nuclear facilities, apply the provisions of the Occupational, Health, and Safety Act to certain Department of Energy nuclear facilities, encourage independent research on the effects of radiation on human beings, establish a comprehensive program within the Department of Energy of research, development, and demonstration of methods for waste cleanup and remediation, and establish a process for ensuring cleanup of Department of Energy nuclear facilities

  16. A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease.

    Directory of Open Access Journals (Sweden)

    Kaisa Kyöstilä

    2015-04-01

    Full Text Available Inherited neurodegenerative disorders are debilitating diseases that occur across different species. We have performed clinical, pathological and genetic studies to characterize a novel canine neurodegenerative disease present in the Lagotto Romagnolo dog breed. Affected dogs suffer from progressive cerebellar ataxia, sometimes accompanied by episodic nystagmus and behavioral changes. Histological examination revealed unique pathological changes, including profound neuronal cytoplasmic vacuolization in the nervous system, as well as spheroid formation and cytoplasmic aggregation of vacuoles in secretory epithelial tissues and mesenchymal cells. Genetic analyses uncovered a missense change, c.1288G>A; p.A430T, in the autophagy-related ATG4D gene on canine chromosome 20 with a highly significant disease association (p = 3.8 x 10-136 in a cohort of more than 2300 Lagotto Romagnolo dogs. ATG4D encodes a poorly characterized cysteine protease belonging to the macroautophagy pathway. Accordingly, our histological analyses indicated altered autophagic flux in affected tissues. The knockdown of the zebrafish homologue atg4da resulted in a widespread developmental disturbance and neurodegeneration in the central nervous system. Our study describes a previously unknown canine neurological disease with particular pathological features and implicates the ATG4D protein as an important autophagy mediator in neuronal homeostasis. The canine phenotype serves as a model to delineate the disease-causing pathological mechanism(s and ATG4D function, and can also be used to explore treatment options. Furthermore, our results reveal a novel candidate gene for human neurodegeneration and enable the development of a genetic test for veterinary diagnostic and breeding purposes.

  17. Genome-wide analysis of autophagy-related genes in banana highlights MaATG8s in cell death and autophagy in immune response to Fusarium wilt.

    Science.gov (United States)

    Wei, Yunxie; Liu, Wen; Hu, Wei; Liu, Guoyin; Wu, Chunjie; Liu, Wei; Zeng, Hongqiu; He, Chaozu; Shi, Haitao

    2017-08-01

    MaATG8s play important roles in hypersensitive-like cell death and immune response, and autophagy is essential for disease resistance against Foc in banana. Autophagy is responsible for the degradation of damaged cytoplasmic constituents in the lysosomes or vacuoles. Although the effects of autophagy have been extensively revealed in model plants, the possible roles of autophagy-related gene in banana remain unknown. In this study, 32 MaATGs were identified in the draft genome, and the profiles of several MaATGs in response to fungal pathogen Fusarium oxysporum f. sp. cubense (Foc) were also revealled. We found that seven MaATG8s were commonly regulated by Foc. Through transient expression in Nicotiana benthamiana leaves, we highlight the novel roles of MaATG8s in conferring hypersensitive-like cell death, and MaATG8s-mediated hypersensitive response-like cell death is dependent on autophagy. Notablly, autophagy inhibitor 3-methyladenine (3-MA) treatment resulted in decreased disease resistance in response to Foc4, and the effect of 3-MA treatment could be rescued by exogenous salicylic acid, jasmonic acid and ethylene, indicating the involvement of autophagy-mediated plant hormones in banana resistance to Fusarium wilt. Taken together, this study may extend our understanding the putative role of MaATG8s in hypersensitive-like cell death and the essential role of autophagy in immune response against Foc in banana.

  18. Our contribution to the debate on the programming act on energy transition

    International Nuclear Information System (INIS)

    2014-01-01

    This publication states the position of the UFIP (the French Union of oil industries) on the energy context in order to provide a contribution to the French policy for energy transition. It outlines the still very important share of oil in the French energy mix (in primary and final energy, and more particularly in transports), and that, despite the development of other energies, an energy transition is always very slow. It discusses the perspectives for hydrocarbon reserves and production of oil and natural gas. It discusses the possible role shale hydrocarbons may have in the future. It outlines that oil remains the most important energy for mobility, the benefits of conventional fuels, the French energy taxing policy and environmental taxing policy, the issue of security of energy supply (with its different components: exploration-production, refining, logistics and depots, distribution and station network). It outlines the high contribution of oil industry to economic activity and employment in France, and discusses the evolution of the economic situation (margin) of the refining activity

  19. Renewable Energy Sources Act and Trading of Emission Certificates: A national and a supranational tool direct energy turnover to renewable electricity-supply in Germany

    International Nuclear Information System (INIS)

    Kirsten, Selder

    2014-01-01

    Aim: After the nuclear disaster at Fukushima in 2011, Germany decided to phase out atomic energy, without producing new CO 2 emissions. The article discusses the promotion systems that are used. Scope: The percentage of renewable energies in Germany's electricity consumption increased from 3 in 1990 to 23 in 2012. This development was introduced and guided by a law called Renewable Energy Sources Act. It guarantees a privileged acceptance of electricity and a fixed gratification for 20 years to the operators of regenerative power plants. It allows the operators to install regenerative power plants at a reduced risk. By contrast, the international means for CO 2 reduction is the trading of emission certificates, which is also valid for Germany. The article discusses how the promotion of the Erneuerbar-Energien-Gesetz (EEG) and other plant-based promotion systems fit into this condition. It also elucidates the actual decline of promotion, its problems to the country’s environmental economy and the approach of decentralized photovoltaic (PV) energy plants towards economical efficiency. Conclusions: Germany’s energy turnaround to a regenerative energy supply is characterized by a strong and differentiated promotion system. Substantial efforts have to be made as the percentage of the renewable energy sources has significantly increased but is still under 25%

  20. Requirements and impacts of the Federal Facility Compliance Act on the Department of Energy

    Energy Technology Data Exchange (ETDEWEB)

    Chang, L.; Tripp, S.C. [Dept. of Energy, Washington, DC (United States). Office of Environmental Restoration and Waste Management

    1993-03-01

    The Federal Facilities Compliance Act (FFCA, the Act) was signed into law on October 6, 1992, primarily as a means of waiving sovereign immunity for federal facilities with respect to requirements under the Resource Conservation and Recovery Act. DOE`s implementation of the FFCA will have significant effects on current and future DOE waste management operations. DOE will need to rethink its strategy in the area of future compliance agreements to ensure commitments and deliverables are made consistent throughout the different DOE facilities. Several types of agreements that address mixed waste land disposal restriction (LDR) compliance have already been signed by both DOE and the regulators. These agreements are in place at the Hanford Reservation, the Savannah River Site, the Oak Ridge Reservation (Oak Ridge National Laboratory, K-25, Y-12), and the Paducah Gaseous Diffusion Plant. The Rocky Flats Agreement is now being renegotiated. Los Alamos National Laboratory, Sandia/Albuquerque National Laboratory, Lawrence Livermore National Laboratory, and Idaho National Engineering Laboratory agreements are in progress. Major components of the FFCA include provisions on: sovereign immunity waiver; cost reimbursements; mixed waste requirements, including inventory reports on mixed waste and treatment capacity and technologies; and plans for the development of treatment capacities and technologies. Each of these components is discussed within this paper.

  1. Enerplan, activity report 2009. Acting for solar energy promotion and development

    International Nuclear Information System (INIS)

    2010-01-01

    Enerplan is the French union of solar energy professionals. Created in 1983, its social purpose is the study and defense of the rights and of the material and moral interests of its members. Enerplan structures its action through two poles representing members' activities: 'solar energy and building' where topics about heat and electricity generation in relation with buildings are treated, and 'photovoltaic energy' where topics specific to big solar power plants are considered. Thanks to the collaborative participation of its members, both poles allow Enerplan union to be source of proposals to develop solar energy in France. As an active interface between professionals and institutions, Enerplan includes in its membership: industrialists, plant makers, engineering consultants, installers, associations, energy suppliers etc, from small-medium size companies to big groups. This document presents Enerplan's activities in 2009 (public relations, lobbying, meetings and conferences, promotional activities, collaborations, projects..)

  2. Decree of 11 August 1973 amending the Radioactive Materials (Nuclear Energy Act) Decree (Bulletin of Acts, Orders and Decrees 404/1969)

    International Nuclear Information System (INIS)

    Anon.

    1973-01-01

    This Decree amends the Radioactive Materials (Nuclear Energy Act) Decree of 1969 in order to insert special regulations for the use of radioactive luminous paint in timepieces. The amendment, which consists of a new Part 4a and an Annex to the 1969 Decree incorporates in Netherlands legislation the Radiation Protection Standards for Radioluminous Timepieces recommended for adoption by the OECD Council on 19th July 1966 and by the IAEA Board of Governors on 19th September 1966. An Explanatory Memorandum is also attached to the Decree. The new provisions specify the permissible nuclides as well as their activity limits for the different categories of timepieces, the markings, the requirements for the cases. The Annex lays down the tests and inspections to be carried out during manufacture of the timepieces; finally, the Explanatory Memorandum states that these standards have been incorporated with national legislation, in view of the increasing use of such products and analyses the new provisions. (N.E.A.) [fr

  3. 78 FR 78305 - Energy and Water Use Labeling for Consumer Products Under the Energy Policy and Conservation Act...

    Science.gov (United States)

    2013-12-26

    ... that your comment does not include any sensitive personal information, such as anyone's Social Security... Part 305 Advertising, Energy conservation, Household appliances, Labeling, reporting and recordkeeping... as HDMI, Component video, Svideo, Composite video; and/or (3) Media storage devices such as a USB...

  4. Resolution of the Conference of Ministers of Economics of the German Laender, relating to the act obliging electric utilities to purchase electricity generated from renewable energy sources (Stromeinspeisungsgesetz)

    International Nuclear Information System (INIS)

    Anon.

    1996-01-01

    The Conference of Ministers welcomes the minimum payment for electricity generated from renewable energy sources as defined in the planned act as a suitable incentive to exploit renewable energy sources, but at the same time regrets that the Federal Government still does not give appropriate support in general to enhanced use of these energy sources. The resolution comprises seven statements. (orig./CB) [de

  5. Can Culture Act as an Enabler to Innovation? Exploring the Germany-Ontario Experience Regarding the Introduction of Green Energy

    Directory of Open Access Journals (Sweden)

    Bill Irwin

    2015-02-01

    Full Text Available This paper explores the role that societal culture may play in terms of acting as an inhibitor or enabler when creating conditions conducive to innovative enterprise. To further understanding of this concept, the paper's authors explore different cultural influences and traditions of the country of Germany and the Canadian province of Ontario against the backdrop of the introduction of a government green energy policy and how local business reacts to new opportunities forthcoming from this shift in policy direction. The authors contend that the current Ontario psyche has contributed to an overall cultural drag on innovative activities. They demonstrate that in no place is this cultural impact more evident than the apparent lack of home-grown innovative activity surrounding green energy entrepreneurship; where, in spite of progressive and favourable provincial government policy, continued manufacturing growth is led by offshore companies The Ontario experience is in sharp contrast to current and historical German activity, when it comes to local innovation and advances in green energy. While Germany officially enacted their green energy act at the turn of the last century, experts agree that the German tenure with going green is in fact 35 to 40 years in the making. Although it has been contended that unique historical conditions such as postwar reconstruction and the reunification of the former East and West Germany have been significant contributing factors to Germany's embracing of sustainable energy, the authors of this paper contend that cultural factors such as the German sense of naturfreund; an overwhelming sense of being a nature-lover, may also play a significant role. In their exploration the authors build upon Hofstede's cultural dimension theory unpacking specific cultural components, as they compare actions and responses made by German and Ontarian policy-makers and business decision-makers.

  6. Recovery Act - CAREER: Sustainable Silicon -- Energy-Efficient VLSI Interconnect for Extreme-Scale Computing

    Energy Technology Data Exchange (ETDEWEB)

    Chiang, Patrick [Oregon State Univ., Corvallis, OR (United States)

    2014-01-31

    The research goal of this CAREER proposal is to develop energy-efficient, VLSI interconnect circuits and systems that will facilitate future massively-parallel, high-performance computing. Extreme-scale computing will exhibit massive parallelism on multiple vertical levels, from thou­ sands of computational units on a single processor to thousands of processors in a single data center. Unfortunately, the energy required to communicate between these units at every level (on­ chip, off-chip, off-rack) will be the critical limitation to energy efficiency. Therefore, the PI's career goal is to become a leading researcher in the design of energy-efficient VLSI interconnect for future computing systems.

  7. Clean Air Act Standards and Guidelines for Energy, Engines, and Combustion

    Science.gov (United States)

    This page contains the stationary sources of air pollution for the energy, engines, and combustion industries, and their corresponding air pollution regulations. To learn more about the regulations for each industry, just click on the links below.

  8. Korea act on compensation for nuclear damage (as amended on 16 January 2001). Norway act on radiation protection and use of radiation (12 May 2000). Poland atomic energy act (29 November 2000)

    International Nuclear Information System (INIS)

    2001-01-01

    This volume reprints the English and French translation of three nuclear laws. The first law concerns Korea and its purpose is to protect victims and to contribute to the sound development of the nuclear industry by establishing matters relating to compensation in the event of nuclear damage arising during the operation of a nuclear reactor. The second law concerns Norway and its purpose is to prevent the harmful effects of radiation on human health and to contribute to the protection of the environment. It applies to any production, import, export, transport, transfer, possession, installation, use, handling and waste management of radiation sources. It applies also to human activities which causes increased levels of naturally-occurring ionizing radiation in the environment, and to planning and emergency preparedness against incidents and accidents. The last law is the atomic energy act of Poland. It defines the activities related to the peaceful use of atomic energy, involving real and potential exposures to ionizing radiation emitted by artificial radioactive sources, nuclear materials, devices generating ionizing radiation, radioactive waste and spent fuel. It defines also duties of the head of the organisational entity conducting these activities, the authorities competent in the area of nuclear safety and radiological protection, and the principles of third party liability for nuclear damage. The act also establishes financial penalties for the violation of nuclear regulations and the rules for imposing such penalties. It applies also to practices conducted in conditions of exposure to natural ionizing radiation enhanced by human activity. Finally, it defines the principles of radioactive contamination monitoring and establishes rules governing activities undertaken in the event of a radiological emergency as well as in chronic exposure conditions in the aftermath of a radiological emergency or a past practice

  9. Decree of 22 October 1969, Stb. 474, concerning the implementation of Section 58, paragraph 4 of the Nuclear Energy Act (Duties of Food and Drugs Inspectors)

    International Nuclear Information System (INIS)

    1969-01-01

    This Decree defines the responsibilities of municipal and provincial food and drug inspectors appointed under the Nuclear Energy Act. They are required to ascertain that the provisions of the Act concerning the protection of the biological, chemical and physical human environment are observed. Their duties do not include the protection of workers. (NEA) [fr

  10. Modeling Innovative Power Take-Off Based on Double-Acting Hydraulic Cylinders Array for Wave Energy Conversion

    Directory of Open Access Journals (Sweden)

    Juan Carlos Antolín-Urbaneja

    2015-03-01

    Full Text Available One of the key systems of a Wave Energy Converter for extraction of wave energy is the Power Take-Off (PTO device. This device transforms the mechanical energy of a moving body into electrical energy. This paper describes the model of an innovative PTO based on independently activated double-acting hydraulic cylinders array. The model has been developed using a simulation tool, based on a port-based approach to model hydraulics systems. The components and subsystems used in the model have been parameterized as real components and their values experimentally obtained from an existing prototype. In fact, the model takes into account most of the hydraulic losses of each component. The simulations show the flexibility to apply different restraining torques to the input movement depending on the geometrical configuration and the hydraulic cylinders on duty, easily modified by a control law. The combination of these two actions allows suitable flexibility to adapt the device to different sea states whilst optimizing the energy extraction. The model has been validated using a real test bench showing good correlations between simulation and experimental tests.

  11. Decree of 13 October 1969, Stb. 473, concerning the implementation of Section 56, paragraph 4 of the Nuclear Energy Act (Appeals)

    International Nuclear Information System (INIS)

    1969-01-01

    This Decree concerns the conditions attached to the licences required under the Nuclear Energy Act. It provides for the procedure for lodging appeals against additional conditions which may be imposed upon applicants for a licence. (NEA) [fr

  12. Recovery Act: Energy Efficiency of Data Networks through Rate Adaptation (EEDNRA) - Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Matthew Andrews; Spyridon Antonakopoulos; Steve Fortune; Andrea Francini; Lisa Zhang

    2011-07-12

    This Concept Definition Study focused on developing a scientific understanding of methods to reduce energy consumption in data networks using rate adaptation. Rate adaptation is a collection of techniques that reduce energy consumption when traffic is light, and only require full energy when traffic is at full provisioned capacity. Rate adaptation is a very promising technique for saving energy: modern data networks are typically operated at average rates well below capacity, but network equipment has not yet been designed to incorporate rate adaptation. The Study concerns packet-switching equipment, routers and switches; such equipment forms the backbone of the modern Internet. The focus of the study is on algorithms and protocols that can be implemented in software or firmware to exploit hardware power-control mechanisms. Hardware power-control mechanisms are widely used in the computer industry, and are beginning to be available for networking equipment as well. Network equipment has different performance requirements than computer equipment because of the very fast rate of packet arrival; hence novel power-control algorithms are required for networking. This study resulted in five published papers, one internal report, and two patent applications, documented below. The specific technical accomplishments are the following: • A model for the power consumption of switching equipment used in service-provider telecommunication networks as a function of operating state, and measured power-consumption values for typical current equipment. • An algorithm for use in a router that adapts packet processing rate and hence power consumption to traffic load while maintaining performance guarantees on delay and throughput. • An algorithm that performs network-wide traffic routing with the objective of minimizing energy consumption, assuming that routers have less-than-ideal rate adaptivity. • An estimate of the potential energy savings in service-provider networks

  13. American Recovery and Reinvestment Act (ARRA) Federal Energy Management Program Technical Assistance Project 282 Renewable Energy Opportunities at Fort Gordon, Georgia

    Energy Technology Data Exchange (ETDEWEB)

    Boyd, Brian K.; Gorrissen, Willy J.; Hand, James R.; Horner, Jacob A.; Orrell, Alice C.; Russo, Bryan J.; Weimar, Mark R.; Williamson, Jennifer L.; Nesse, Ronald J.

    2010-09-30

    This document provides an overview of renewable resource potential at Fort Gordon, based primarily upon analysis of secondary data sources supplemented with limited on-site evaluations. This effort focuses on grid-connected generation of electricity from renewable energy sources and also on ground source heat pumps for heating and cooling buildings. The effort was funded by the American Recovery and Reinvestment Act (ARRA) as follow-on to the 2005 Department of Defense (DoD) Renewables Assessment. The site visit to Fort Gordon took place on March 9, 2010.

  14. Energy, economic and environmental discourses and their policy impact: The case of Ontario's Green Energy and Green Economy Act

    International Nuclear Information System (INIS)

    Winfield, Mark; Dolter, Brett

    2014-01-01

    This paper examines the debates around the Ontario's Green Energy and Green Economy Act (GEGEA) as an energy and economic development strategy through comparative public policy and discourse analysis approaches. The evidence regarding the economic impacts of the GEGEA is found to be almost entirely based on the results of economic modeling exercises. Critics and supporters of the legislation have arrived at very different conclusions through such exercises. These outcomes are similar to those seen in other jurisdictions pursuing renewable energy initiatives, such as Feed In Tariffs (FITs), renewables obligations and portfolio standards. A discourse analysis approach is employed to examine the reasons for the different conclusions being reached over the impacts of renewable energy initiatives. Differences in modeling approaches and assumptions are found to reflect differences in ideational perspectives on the part of the modelers with respect to the appropriate roles of markets and the state and the relationship between economic development and environmental sustainability in public policy. The paper concludes with suggestions regarding the gathering and availability of information regarding economic development in the renewable energy sector, and a discussion of potential ways to strengthen future efforts to understand the economic and environmental impact of renewable energy initiatives. - Highlights: • The discourse surrounding renewable energy initiatives is embedded within wider ideological debates. • The information that underpins the debates in Ontario is the result of economic modelling, not empirical data. • All of the existing modelling efforts suffer from significant shortcomings. • FITS are seen as politically feasible mechanisms for correcting biases in favour of conventional technologies. • The province's long-term commitment of renewable energy development is now uncertain

  15. Energy Policy Act transportation rate study: Interim report on coal transportation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-10-01

    The primary purpose of this report is to examine changes in domestic coal distribution and railroad coal transportation rates since enactment of the Clean Air Act Amendments of 1990 (CAAA90). From 1988 through 1993, the demand for low-sulfur coal increased, as a the 1995 deadline for compliance with Phase 1 of CAAA90 approached. The shift toward low-sulfur coal came sooner than had been generally expected because many electric utilities switched early from high-sulfur coal to ``compliance`` (very low-sulfur) coal. They did so to accumulate emissions allowances that could be used to meet the stricter Phase 2 requirements. Thus, the demand for compliance coal increased the most. The report describes coal distribution and sulfur content, railroad coal transportation and transportation rates, and electric utility contract coal transportation trends from 1979 to 1993 including national trends, regional comparisons, distribution patterns and regional profiles. 14 figs., 76 tabs.

  16. Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growth.

    Science.gov (United States)

    Bao, Xing; Ren, Tingting; Huang, Yi; Sun, Kunkun; Wang, Shidong; Liu, Kuisheng; Zheng, Bingxin; Guo, Wei

    2017-02-09

    Current practices for the therapy of chondrosarcoma, including wide-margin surgical resection and chemotherapy, are less than satisfactory. Recently, emerging evidence has demonstrated that long non-coding RNAs (lncRNAs) have an essential role in the initiation and progression of tumors. As a typical lncRNA, HOTAIR is significantly overexpressed in various tumors. However, the function and potential biological mechanisms of HOTAIR in human chondrosarcoma remain unknown. Quantitative RT-PCR demonstrated that HOTAIR expression was upregulated in chondrosarcoma tissues and cell lines. High HOTAIR expression is correlated with tumor stage and poor prognosis. Functional experiments reveal that HOTAIR knockdown leads to growth inhibition of human chondrosarcoma cells in vitro and in vivo. In addition to cycle arrest and apoptosis, knockdown of HOTAIR inhibits autophagy, which favors cell death. Mechanistically, we demonstrated that HOTAIR induced DNA methylation of miR-454-3p by recruiting EZH2 and DNMT1 to the miR-454-3p promoter regions, which markedly silences miR-454-3p expression. Further analysis revealed that STAT3 and ATG12 are targets of miR-454-3p, initiate HOTAIR deficiency-induced apoptosis and reduce autophagy. Collectively, our data reveal the roles and functional mechanisms of HOTAIR in human chondrosarcoma and suggest that HOTAIR may act as a prognostic biomarker and potential therapeutic target for chondrosarcoma.

  17. Think globally, act locally? Local climate change and energy policies in Sweden and the UK

    International Nuclear Information System (INIS)

    Collier, U.; Loefstedt, R.E.

    1997-01-01

    While climate change is obviously a global environmental problem, there is nevertheless potential for policy initiatives at the local level. Although the competences of local authorities vary between countries, they all have some responsibilities in the crucial areas of energy and transport policy. This paper examines local competences in Sweden and the UK and looks at the responses to the climate change issue by six local authorities, focussing on energy related developments. The points of departure are very different in the two countries. Swedish local authorities are much more independent than UK ones, especially through the ownership of local energy companies. Yet, UK local authorities are relatively active in the climate change domain, at least in terms of drawing up response strategies, which they see as an opportunity for reasserting their role, after a long period of erosion of their powers. Furthermore, there is more scope for action in the UK, as in Sweden many potential measures, especially in the energy efficiency field, have already been taken. However, in both countries climate change is only a relatively marginal area of local environmental policy making and the political will, as well as the financial resources, for more radical measures are often absent. (Author)

  18. Recovery Act: Tennessee Energy Efficient Schools Initiative Ground Source Heat Pump Program

    Energy Technology Data Exchange (ETDEWEB)

    Townsend, Terry [Townsend Engineering, Inc., Davenport, IA (United States); Slusher, Scott [Townsend Engineering, Inc., Davenport, IA (United States)

    2017-04-24

    The Tennessee Energy Efficient Schools Initiative (EESI) Hybrid-Water Source Heat Pump (HY-GSHP) Program sought to provide installation costs and operation costs for different Hybrid water source heat pump systems’ configurations so that other State of Tennessee School Districts will have a resource for comparison purposes if considering a geothermal system.

  19. Color van der Waals force acting in heavy-ion scattering at low energies

    International Nuclear Information System (INIS)

    Hussein, M.S.; Lima, C.L.; Pato, M.P.; Bertulani, C.A.

    1990-01-01

    The influence of the color van der Waals force in the elastic scattering of 208 Pb on 208 Pb at sub-barrier energies is studied. The conspicuous changes in the Mott oscillation found here are suggested as a possible experimental test

  20. Improved long-term survival after intra-operative single high-dose ATG-Fresenius induction in renal transplantation: a single centre experience.

    Science.gov (United States)

    Kaden, Jürgen; May, Gottfried; Völp, Andreas; Wesslau, Claus

    2009-01-01

    In organ grafts donor-specific sensitization is initiated immediately after revascularization. Therefore, in 1990 we introduced the intra-operative single high-dose ATG-Fresenius (ATG-F) induction in addition to standard triple drug therapy (TDT) consisting of steroids, azathioprine and cyclosporin. A total of 778 first renal transplantations from deceased donors, performed between 1987 and 1998, were included in this evaluation. This retrospective analysis of clinic records and electronic databases presents data of all recipients of first kidney grafts who received two different ATG-F inductions (1(st) group: 9 mg/kg body weight as single high-dose intra-operatively, n=484; 2(nd) group: 3 mg/kg body weight on 7 or 8 consecutive days as multiple-dose starting also intra-operatively, n=78) and standard TDT alone (3(rd) group: TDT alone, n=216). The 10-year patient survival rates were 72.6+/-2.6% (TDT + ATG-F single high-dose), 79.5+/-5.1% (TDT + ATG-F multiple-dose) and 67.2+/-3.7%% (TDT alone; Kaplan-Meier estimates with standard errors; ATG-F vs TDT alone, p=0.001). The 10-year graft survival rates with censoring of patients that died with a functioning graft were 73.8+/-2.4%, 57.7+/-5.8% and 58.4+/-3.6% (Kaplan-Meier estimates with standard errors; 1(st) vs 2(nd )and 3(rd) group, respectively, p<0.001) and the 10-year graft survival rates with patient death counted as graft failure were 58.3+/-2.7%, 55.7+/-5.8% and 48.2+/-3.5% (Kaplan-Meier estimates with standard errors; ATG-F single high-dose vs TDT, p=0.023). In pre-sensitized recipients there were also significant differences in favour of ATG-F, more notably in the single high-dose ATG-F induction. A total of 69% of the patients in the two cohorts receiving ATG-F did not experience any transplant rejections compared to 56% in patients undergoing TDT alone (p=0.018). The incidence of infectious complications was comparable across all groups. According to evidence obtained from the routine documentation of 778

  1. One year results of preoperative single bolus ATG-Fresenius induction therapy in sensitized renal transplant recipients.

    Science.gov (United States)

    Wang, D; Chen, J H; Wu, W Z; Yang, S L; Wu, G J; Wang, H; Tan, J M

    2007-01-01

    Sensitization in kidney transplantation is associated with more acute rejections, inferior graft survival, and an increase in delayed graft function. This study was designed to evaluate the efficacy and safety of preoperative single bolus antithymocyte globulin (ATG) induction therapy in sensitized renal transplant recipients. Fifty-six cadaveric donor kidney transplant recipients were divided into two groups: Group I (nonsensitized group, n = 30) and group II (sensitized group, PRA>10%, n = 26). ATG was given as a single preoperative bolus induction therapy to group II (ATG IV; 9 mg/kg). The group I patients were treated with mycophenolate mofetil preoperatively as induction therapy. The basic immunosuppressive regimen included tacrolimus (FK-506) or cyclosporine, mycophenolate mofetil, and prednisolone. After hospital discharge, patients were followed on a routine outpatient basis for 12 months. Acute rejection episodes (ARE) occurred in 20% (6/30) of group I and 15.38% (4/26) of group II patients (P = NS). Infections occurred in eight patients (26.7%) as 11 episodes (36.7%), averaging 1.4 episodes per infected patient in group 1, and 6 patients (23.1%) for a total of 10 episodes (38.5%), averaging 1.7 episodes per infected patient, in group II (P = NS). Occurrence of side effects and hospital stay were almost comparable in the two groups. No delayed graft function was observed in either group. The 12-month actuarial patient and graft survival were 100% in Group I and II. A preoperative single bolus ATG induction therapy was an effective and safe therapeutic measure, yielding an acceptable acute rejection rate in presensitized renal transplant recipients.

  2. Energy transport corridors: the potential role of Federal lands in states identified by the Energy Policy Act of 2005, section 368(b).

    Energy Technology Data Exchange (ETDEWEB)

    Krummel, J.; Hlohowskyj, I.; Kuiper, J.; Kolpa, R.; Moore, R.; May, J.; VanKuiken, J.C.; Kavicky, J.A.; McLamore, M.R.; Shamsuddin, S. (Decision and Information Sciences); ( EVS)

    2011-09-01

    On August 8, 2005, the President signed the Energy Policy Act of 2005 (EPAct) into law. In Subtitle F of EPAct, Congress set forth various provisions that would change the way certain federal agencies (Agencies) coordinate to authorize the use of land for a variety of energy-related purposes. As part of Subtitle F of EPAct, Section 368 addresses the issue of energy transportation corridors on federal land for oil, gas, and hydrogen pipelines, as well as electricity transmission and distribution facilities. Because of the critical importance of improving the nation's electrical transmission grid, Congress recognized that electricity transmission issues should receive added attention when the Agencies address corridor location and analysis issues. In Section 368, Congress specifically directed the Agencies to consider the need for upgraded and new facilities to deliver electricity: In carrying out [Section 368], the Secretaries shall take into account the need for upgraded and new electricity transmission and distribution facilities to (1) improve reliability; (2) relieve congestion; and (3) enhance capability of the national grid to deliver electricity. Section 368 does not require the Agencies to consider or approve specific projects, applications for rights-of-way (ROWs), or other permits within designated energy corridors. Importantly, Section 368 does not direct, license, or otherwise permit any on-the-ground activity of any sort. If an applicant is interested in obtaining an authorization to develop a project within any corridor designated under Section 368, the applicant would have to apply for a ROW authorization and applicable permits. The Agencies would consider each application by applying appropriate project-specific reviews under requirements of laws and related regulations, including, but not limited to, the National Environmental Policy Act (NEPA), the Clean Water Act, the Clean Air Act, Section 7 of the Endangered Species Act (ESA), and Section

  3. MdATG18a overexpression improves tolerance to nitrogen deficiency and regulates anthocyanin accumulation through increased autophagy in transgenic apple.

    Science.gov (United States)

    Sun, Xun; Jia, Xin; Huo, Liuqing; Che, Runmin; Gong, Xiaoqing; Wang, Ping; Ma, Fengwang

    2018-02-01

    Nitrogen (N) availability is an essential factor for plant growth. Recycling and remobilization of N have strong impacts on crop yield and quality under N deficiency. Autophagy is a critical nutrient-recycling process that facilitates remobilization under starvation. We previously showed that an important AuTophaGy (ATG) protein from apple, MdATG18a, has a positive role in drought tolerance. In this study, we explored its biological role in response to low-N. Overexpression of MdATG18a in both Arabidopsis and apple improved tolerance to N-depletion and caused a greater accumulation of anthocyanin. The increased anthocyanin concentration in transgenic apple was possibly due to up-regulating flavonoid biosynthetic and regulatory genes (MdCHI, MdCHS, MdANS, MdPAL, MdUFGT, and MdMYB1) and higher soluble sugars concentration. MdATG18a overexpression enhanced starch degradation with up-regulating amylase gene (MdAM1) and up-regulated sugar metabolism related genes (MdSS1, MdHXKs, MdFK1, and MdNINVs). Furthermore, MdATG18a functioned in nitrate uptake and assimilation by up-regulating nitrate reductase MdNIA2 and 3 high-affinity nitrate transporters MdNRT2.1/2.4/2.5. MdATG18a overexpression also elevated other important MdATG genes expression and autophagosomes formation under N-depletion, which play key contributions to above changes. Together, these results demonstrate that overexpression of MdATG18a enhances tolerance to N-deficiencies and plays positive roles in anthocyanin biosynthesis through greater autophagic activity. © 2017 John Wiley & Sons Ltd.

  4. Simplification of the Provisions of the Nuclear Energy Act on Imports and Exports; A Working Group Report

    International Nuclear Information System (INIS)

    2001-01-01

    The Ministry of Trade and Industry appointed a working group to map out possibilities of simplifying the provisions on imports and exports of nuclear products and to submit a proposal for the amendment of the Nuclear Energy Act in this respect. The working group should especially map out relevant international and EU norms and consider to what extent it would be possible to replace the present licensing procedure with obligations imposed on operators and/or a notification procedure. The working group should further study the possibility of combining the provisions on the control of nuclear materials, the safety of transports of nuclear and other radioactive material nuclear liability and physical protection of nuclear materials with the provisions on imports and exports. The working group did not discuss the provisions on the imports and exports of nuclear waste. The Council Regulation concerning the control of exports of dual-use items and technology, which entered into force in September 2000, and the amendment of the Regulation with a view to nuclear material adopted in January 2001 call for an amendment of the provisions of the Nuclear Energy Act concerning exports. The working group proposes that a direct reference to the EU Regulation should be included in the Nuclear Energy Decree. The definition of exports is proposed to be changed so that it corresponds to the definition in the EU Regulation. The Nuclear Energy Decree should, however, comprise provisions on applying for an authorization, on a licensing authority and on the possibility of applying for a global authorisation. The global authorisation shall replace the Intra-Community trade licence, which is proposed to be abolished. It is proposed that the Ministry of Trade and Industry should be the licensing authority. It is further proposed that provisions should be issued on a notification procedure for products falling under the scope of the Nuclear Energy Act for which no export authorisation is

  5. ATG-Fresenius treatment and low-dose tacrolimus: results of a randomized controlled trial in liver transplantation.

    Science.gov (United States)

    Benítez, C E; Puig-Pey, I; López, M; Martínez-Llordella, M; Lozano, J J; Bohne, F; Londoño, M C; García-Valdecasas, J C; Bruguera, M; Navasa, M; Rimola, A; Sánchez-Fueyo, A

    2010-10-01

    We report the results of a prospective randomized controlled trial in liver transplantation assessing the efficacy and safety of antithymocyte globulin (ATG-Fresenius) plus tacrolimus monotherapy at gradually decreasing doses. Patients were randomized to either: (a) standard-dose tacrolimus plus steroids;or (b) peritransplant ATG-Fresenius plus reduced-dose tacrolimus monotherapy followed by weaning of tacrolimus starting 3 months after transplantation. The primary end-point was the achievement of very low-dose tacrolimus (every-other-day or once daily dose with Fresenius group but no benefits in terms of improved renal function, lower metabolic complications or increased prevalence of tolerance-related biomarkers were observed. In conclusion, the use of ATG-Fresenius and tacrolimus at gradually decreasing doses was associated with a high rate of rejection, did not allow for the administration of very low doses of tacrolimus and failed to provide detectable clinical benefits. ClinicalTrials.gov identifier: NCT00436722. © 2010 The Authors Journal compilation © 2010 The American Society of Transplantation and the American Society of Transplant Surgeons.

  6. ATG5 overexpression is neuroprotective and attenuates cytoskeletal and vesicle-trafficking alterations in axotomized motoneurons.

    Science.gov (United States)

    Leiva-Rodríguez, Tatiana; Romeo-Guitart, David; Marmolejo-Martínez-Artesero, Sara; Herrando-Grabulosa, Mireia; Bosch, Assumpció; Forés, Joaquim; Casas, Caty

    2018-05-24

    Injured neurons should engage endogenous mechanisms of self-protection to limit neurodegeneration. Enhancing efficacy of these mechanisms or correcting dysfunctional pathways may be a successful strategy for inducing neuroprotection. Spinal motoneurons retrogradely degenerate after proximal axotomy due to mechanical detachment (avulsion) of the nerve roots, and this limits recovery of nervous system function in patients after this type of trauma. In a previously reported proteomic analysis, we demonstrated that autophagy is a key endogenous mechanism that may allow motoneuron survival and regeneration after distal axotomy and suture of the nerve. Herein, we show that autophagy flux is dysfunctional or blocked in degenerated motoneurons after root avulsion. We also found that there were abnormalities in anterograde/retrograde motor proteins, key secretory pathway factors, and lysosome function. Further, LAMP1 protein was missorted and underglycosylated as well as the proton pump v-ATPase. In vitro modeling revealed how sequential disruptions in these systems likely lead to neurodegeneration. In vivo, we observed that cytoskeletal alterations, induced by a single injection of nocodazole, were sufficient to promote neurodegeneration of avulsed motoneurons. Besides, only pre-treatment with rapamycin, but not post-treatment, neuroprotected after nerve root avulsion. In agreement, overexpressing ATG5 in injured motoneurons led to neuroprotection and attenuation of cytoskeletal and trafficking-related abnormalities. These discoveries serve as proof of concept for autophagy-target therapy to halting the progression of neurodegenerative processes.

  7. ATG18 and FAB1 are involved in dehydration stress tolerance in Saccharomyces cerevisiae.

    Science.gov (United States)

    López-Martínez, Gema; Margalef-Català, Mar; Salinas, Francisco; Liti, Gianni; Cordero-Otero, Ricardo

    2015-01-01

    Recently, different dehydration-based technologies have been evaluated for the purpose of cell and tissue preservation. Although some early results have been promising, they have not satisfied the requirements for large-scale applications. The long experience of using quantitative trait loci (QTLs) with the yeast Saccharomyces cerevisiae has proven to be a good model organism for studying the link between complex phenotypes and DNA variations. Here, we use QTL analysis as a tool for identifying the specific yeast traits involved in dehydration stress tolerance. Three hybrids obtained from stable haploids and sequenced in the Saccharomyces Genome Resequencing Project showed intermediate dehydration tolerance in most cases. The dehydration resistance trait of 96 segregants from each hybrid was quantified. A smooth, continuous distribution of the anhydrobiosis tolerance trait was found, suggesting that this trait is determined by multiple QTLs. Therefore, we carried out a QTL analysis to identify the determinants of this dehydration tolerance trait at the genomic level. Among the genes identified after reciprocal hemizygosity assays, RSM22, ATG18 and DBR1 had not been referenced in previous studies. We report new phenotypes for these genes using a previously validated test. Finally, our data illustrates the power of this approach in the investigation of the complex cell dehydration phenotype.

  8. ATG18 and FAB1 are involved in dehydration stress tolerance in Saccharomyces cerevisiae.

    Directory of Open Access Journals (Sweden)

    Gema López-Martínez

    Full Text Available Recently, different dehydration-based technologies have been evaluated for the purpose of cell and tissue preservation. Although some early results have been promising, they have not satisfied the requirements for large-scale applications. The long experience of using quantitative trait loci (QTLs with the yeast Saccharomyces cerevisiae has proven to be a good model organism for studying the link between complex phenotypes and DNA variations. Here, we use QTL analysis as a tool for identifying the specific yeast traits involved in dehydration stress tolerance. Three hybrids obtained from stable haploids and sequenced in the Saccharomyces Genome Resequencing Project showed intermediate dehydration tolerance in most cases. The dehydration resistance trait of 96 segregants from each hybrid was quantified. A smooth, continuous distribution of the anhydrobiosis tolerance trait was found, suggesting that this trait is determined by multiple QTLs. Therefore, we carried out a QTL analysis to identify the determinants of this dehydration tolerance trait at the genomic level. Among the genes identified after reciprocal hemizygosity assays, RSM22, ATG18 and DBR1 had not been referenced in previous studies. We report new phenotypes for these genes using a previously validated test. Finally, our data illustrates the power of this approach in the investigation of the complex cell dehydration phenotype.

  9. NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus

    Science.gov (United States)

    Cantó, Carles; Menzies, Keir; Auwerx, Johan

    2015-01-01

    NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD+ metabolism revived interest in NAD+ boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. In this review, we summarize how NAD+ metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited. PMID:26118927

  10. H.R. 2605: Energy and Water Development Appropriations Act, 2000

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    Appropriations are made for the following purposes: (1) Corps of Engineers for general investigations, construction, flood control, operation and maintenance, regulatory program, general expenses, revolving fund, and administrative provision; (2) Dept. of the Interior for the central Utah project, Bureau of Reclamation, water and related resources, Central Valley project restoration fund, California Bay-Delta restoration, and administrative provisions; (3) Dept. of Energy for energy supply, non-defense environmental management, uranium enrichment decontamination and decommissioning fund, science, nuclear waste disposal, and departmental administration; (4) Atomic Energy Defense activities for weapon activities, defense environmental restoration and waste management, defense environmental management privatization, and defense nuclear waste disposal; (5) Power marketing administrations for Bonneville Power Administration fund, operation and maintenance of the Southeastern Power Administration, the Southwestern Power Administration, the Western Area Power Administration, Falcon and Amistad operating and maintenance fund, and salaries and expenses for FERC; (6) Independent agencies including Appalachian Regional Commission, Denali Commission, Defense Nuclear Facilities Safety Board, Nuclear Regulatory Commission, Office of Inspector General, Nuclear Waste Technical Review Board, and the Tennessee Valley Authority fund. Certain appropriations are also rescinded.

  11. Crisis or not, renewable energy is hot. To reap the rewards, governments and companies should act now

    International Nuclear Information System (INIS)

    2009-03-01

    2009 brings us new and difficult challenges. But it also offers real opportunities to change the course of our economies and the impact of the environmental footprint we will leave behind. As the European Union's 2020 environmental targets - 20% less CO2, 20% more energy efficiency, and an overall energy mix comprising 20% renewables - loom nearer, data suggests we are not yet on course to meet these ambitious targets. Despite the economic downturn, now is the time for action. The investments required in renewables could contribute to reverse the economic downtrend. To provide a sound basis for that action, PwC recently examined Europe's future renewable energy marketplace through the lens of progress towards the 2020 goals. This PwC study considers the market's potential, compares approaches in various countries, and puts forth some high-level recommendations for how governments and companies can reap the rewards. Making renewable energy 20% of total energy consumption in the 27 countries of the EU will require an investment of 1.8 to 7.3 trillion euros over the next decade depending on the type of renewable technology. In practical terms, that will mean building more than a million windmills or installing enough solar panels to cover an area twice the size of Belgium. A formidable challenge, no doubt. The opportunities, however, are proportionate to that challenge. The take-away from this study is really quite simple: The renewable market is set to become a major part of the energy sector - and the time to act is now

  12. Authorization process in the sphere of nuclear fuel utilization according to the Bulgarian Act on the Safe Use of Nuclear Energy

    International Nuclear Information System (INIS)

    Stoyanova, P.; Vitkova, M.; Elenkov, D.; Vapirev, E.

    2003-01-01

    The new Bulgarian Act on the Safe Use of Nuclear Energy (ASUNE) was adopted in the year 2002. It replaced the former Act on the Use of Nuclear Energy for Peaceful Purposes, which was in force for about 17 years. The ASUNE covers the activities involving nuclear energy and sources of ionizing radiation mainly by establishing a consistent authorization regime. It is an up-to-date act, based on the IAEA requirements and standards, and yet fully in compliance with the Bulgarian legislative system. The newly adopted Act is based on the following main principles: Priority of safety over economic and other social needs; Occupational and public exposure to ionizing radiation to be kept as low as reasonably achievable (ALARA); Direct and personal liability of the licensee/permit holder; Independence of the regulatory body; Application of a less prescriptive approach; Issuing of authorizations under conditions of legal equality and transparency

  13. Recovery Act: Integrated DC-DC Conversion for Energy-Efficient Multicore Processors

    Energy Technology Data Exchange (ETDEWEB)

    Shepard, Kenneth L

    2013-03-31

    In this project, we have developed the use of thin-film magnetic materials to improve in energy efficiency of digital computing applications by enabling integrated dc-dc power conversion and management with on-chip power inductors. Integrated voltage regulators also enables fine-grained power management, by providing dynamic scaling of the supply voltage in concert with the clock frequency of synchronous logic to throttle power consumption at periods of low computational demand. The voltage converter generates lower output voltages during periods of low computational performance requirements and higher output voltages during periods of high computational performance requirements. Implementation of integrated power conversion requires high-capacity energy storage devices, which are generally not available in traditional semiconductor processes. We achieve this with integration of thin-film magnetic materials into a conventional complementary metal-oxide-semiconductor (CMOS) process for high-quality on-chip power inductors. This project includes a body of work conducted to develop integrated switch-mode voltage regulators with thin-film magnetic power inductors. Soft-magnetic materials and inductor topologies are selected and optimized, with intent to maximize efficiency and current density of the integrated regulators. A custom integrated circuit (IC) is designed and fabricated in 45-nm CMOS silicon-on-insulator (SOI) to provide the control system and power-train necessary to drive the power inductors, in addition to providing a digital load for the converter. A silicon interposer is designed and fabricated in collaboration with IBM Research to integrate custom power inductors by chip stacking with the 45-nm CMOS integrated circuit, enabling power conversion with current density greater than 10A/mm2. The concepts and designs developed from this work enable significant improvements in performance-per-watt of future microprocessors in servers, desktops, and mobile

  14. S.741: This Act may be cited as the National Energy Efficiency and Development Act of 1991, introduced in the Senate of the United States, One Hundred Second Congress, First Session, March 21, 1991

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    The bill would promote cost effective energy efficiency improvements in all sectors of the economy, promote the use of natural gas and encourage increased energy production, thereby reducing the Nations's dependence on imported oil and enhancing the Nation's environmental and economic competitiveness. Contents include: Measures to improve the energy efficiency of the US economy (Research and development, Industrial energy efficiency, Efficiency in commercial and residential buildings and other products, Federal energy management, Utility energy efficiency, Used Oil Energy Production Act of 1991, Tire recycling incentives, and Insular areas energy assistance); Measures to promote the use of renewable energy (Renewable energy technology transfer and Amendments to the Committee on Renewable Energy Commerce and Trade); Measures to promote the use of alternative motor vehicles and fuels (Alternative transportation fuels, Alternative fuel fleet requirement, and Electric vehicle technology development and demonstration); Transportation energy efficiency; Measures to displace petroleum as a vehicle fuel; Measures to promote the use of natural gas; and Tax treatment of energy resources (Renewable energy production incentive, Transportation, Building and housing tax credits, Utilities, and Fees and rebates)

  15. H.R. 3184: The Act may be cited as the Department of Energy Minority Economic Impact Revitalization Act. Introduced in the House of Representatives, One Hundredth Congress, First Session, August 4, 1989

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    H.R. 3184 is a bill to establish within the Office of Minority Economics Impact of the Department of Energy (DOE) programs involving loans and grants to enhance the development and operation of minority business enterprises with respect to energy-related business, to amend the Nuclear Waste Policy Act of 1982 to permit the investment of certain funds in the Minority Bank Deposit Program of the Department of the Treasury, and for other purposes

  16. Act No. 1240 of 15 December 1971. Regulations concerning the restructuring of the National Nuclear Energy Commission (CNEN)

    International Nuclear Information System (INIS)

    1972-01-01

    This Act which annuls the preceding Act of 1960 with the exception of Sections 12 to 16, confirms the CNEN's responsibilities. As opposed to the previous Act this Act contains provisions concerning the National Institute for Nuclear Physics (INFN). (NEA) [fr

  17. A statistical analysis of the energy policy act of 2005, its changes to the daylight saving program, and impact on residential energy consumption

    Science.gov (United States)

    Murray, Patrick L.

    Government programs designed to decrease resource consumption, improve productivity and capitalize on extended daylight hours in the summer have been developed and implemented throughout the world for nearly three hundred years. In 2005, The United States government adopted an extended daylight savings program that increases the number of weeks where the country observes Daylight Saving Time (DST) from 31 to 35 weeks. The program took effect in March 2007. Arguments in support of DST programs highlight the portion of electricity consumption attributed to residential lighting in the evening hours. Adjusting clocks forward by one hour in summer months is believed to reduce electricity consumption due to lighting and therefore significantly reduce residential energy consumption during the period of DST. This paper evaluates the efficacy of the changes to DST resulting from the Energy Policy Act of 2005. The study focuses on changes to household electricity consumption during the extended four weeks of DST. Arizona, one of two states that continue to opt out of DST serves as the study's control for a comparison with neighboring states, Colorado, Nebraska, Nevada, New Mexico, Oklahoma, Texas and Utah. Results from the regression analysis of a Difference in Difference model indicate that contrary to evaluations by Congress and the Department of Energy, the four week period of Extended Daylight Saving Time does not produce a significant decrease in per capita electricity consumption in Southwestern states.

  18. Residual risks of the 13{sup th} amendment to the German Atomic Energy Act; Restrisiken der 13. Atomgesetzaenderung

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Horst

    2011-08-15

    The 13th amendment to the German Atomic Energy Act, which was adopted by the German federal parliament on June 30 and entered into force on August 6, 2011, must be judged in the light of its genesis. Federal Chancellor Merkel, in her government declaration of June 9, 2011, had mentioned topics such as residual risk, safety standards, and risk assumptions, on which the federal government, in the week after the event of March 11, 2011, had commissioned the Advisory Committee on Reactor Safeguards (RSK) to conduct a comprehensive safety review of all German nuclear power plants, and appointed an Ethics Committee to write an opinion on safe energy supply. On the basis of quickly drafted reports, the federal cabinet, without any international harmonization (EU, IEA), adopted a draft opt out law on June 6, 2011. How should the declarations by the Federal Chancellor on June 9, 2011 be classified in terms of atomic energy law? In her words, it all revolved around the residual risk. The debate, which has been shifted to the realm of constitutional law, is open to considerations and steps to attack the new opt out law on grounds of material unconstitutionality (violation of the property guarantee under Sec. 14 or the principle of equality under Art.3 of the Basic Law). As far as final storage is concerned, the amendment to the German Atomic Energy Act announced still for this year, also for transposition of the EURATOM Directive of July 19, 2011 about nuclear waste management, the ''re-assessment of the residual risk'' is not likely to play a role. All these events are reminiscent of a sentence by former Federal Chancellor Schmidt: ''The history of the NATO dual-track decision remains a textbook case showing that even in a democracy emotions using ethical arguments, mixed with demagogy, can become strong enough to cast aside balanced reason.'' There is also a distinction by Max Weber between ''ethics of ideology

  19. Ethanol and Acetate Acting as Carbon/Energy Sources Negatively Affect Yeast Chronological Aging

    Directory of Open Access Journals (Sweden)

    Ivan Orlandi

    2013-01-01

    Full Text Available In Saccharomyces cerevisiae, the chronological lifespan (CLS is defined as the length of time that a population of nondividing cells can survive in stationary phase. In this phase, cells remain metabolically active, albeit at reduced levels, and responsive to environmental signals, thus simulating the postmitotic quiescent state of mammalian cells. Many studies on the main nutrient signaling pathways have uncovered the strong influence of growth conditions, including the composition of culture media, on CLS. In this context, two byproducts of yeast glucose fermentation, ethanol and acetic acid, have been proposed as extrinsic proaging factors. Here, we report that ethanol and acetic acid, at physiological levels released in the exhausted medium, both contribute to chronological aging. Moreover, this combined proaging effect is not due to a toxic environment created by their presence but is mainly mediated by the metabolic pathways required for their utilization as carbon/energy sources. In addition, measurements of key enzymatic activities of the glyoxylate cycle and gluconeogenesis, together with respiration assays performed in extreme calorie restriction, point to a long-term quiescent program favoured by glyoxylate/gluconeogenesis flux contrary to a proaging one based on the oxidative metabolism of ethanol/acetate via TCA and mitochondrial respiration.

  20. Molecular identification of GAPDHs in cassava highlights the antagonism of MeGAPCs and MeATG8s in plant disease resistance against cassava bacterial blight.

    Science.gov (United States)

    Zeng, Hongqiu; Xie, Yanwei; Liu, Guoyin; Lin, Daozhe; He, Chaozu; Shi, Haitao

    2018-06-01

    MeGAPCs were identified as negative regulators of plant disease resistance, and the interaction of MeGAPCs and MeATG8s was highlighted in plant defense response. As an important enzyme of glycolysis metabolic pathway, glyceraldehyde-3-P dehydrogenase (GAPDH) plays important roles in plant development, abiotic stress and immune responses. Cassava (Manihot esculenta) is most important tropical crop and one of the major food crops, however, no information is available about GAPDH gene family in cassava. In this study, 14 MeGAPDHs including 6 cytosol GAPDHs (MeGAPCs) were identified from cassava, and the transcripts of 14 MeGAPDHs in response to Xanthomonas axonopodis pv manihotis (Xam) indicated their possible involvement in immune responses. Further investigation showed that MeGAPCs are negative regulators of disease resistance against Xam. Through transient expression in Nicotiana benthamiana, we found that overexpression of MeGAPCs led to decreased disease resistance against Xam. On the contrary, MeGAPCs-silenced cassava plants through virus-induced gene silencing (VIGS) conferred improved disease resistance. Notably, MeGAPCs physically interacted with autophagy-related protein 8b (MeATG8b) and MeATG8e and inhibited autophagic activity. Moreover, MeATG8b and MeATG8e negatively regulated the activities of NAD-dependent MeGAPDHs, and are involved in MeGAPCs-mediated disease resistance. Taken together, this study highlights the involvement of MeGAPCs in plant disease resistance, through interacting with MeATG8b and MeATG8e.

  1. H.R. 1543: This Act may be cited as the Comprehensive Energy Policy Act of 1991, introduced in the House of Representatives, One Hundred Second Congress, First Session, March 21, 1991

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    This bill would encourage cost effective energy conservation and energy efficiency and would permit the exploration, development, production, purchase, and sale of domestic energy resources to the maximum extent practicable and in a manner consistent with environmental values. Sections of the bill describe the following: Conservation and energy efficiency in the electricity sector (electricity and utilities; residential, commercial, and Federal energy use; standards and information; and tax provisions); Conservation in the transportation sector (alternative fuels; natural gas as a transportation fuel; fuel economy; and miscellaneous); Renewable energy sources (PURPA size cap and co-firing reform; hydroelectric power regulatory reform; credit for electricity generated using solar, wind, or geothermal energy; study of tax and rate treatment of renewable energy projects; and encouragement of energy recovery from waste); Electric power (Public Utility Holding Company Act reform; miscellaneous); Natural gas regulatory reform; Oil and gas production (Arctic coastal plain domestic energy leasing; tax incentives for oil and gas exploration and production; oil pipeline deregulation; leasing of Naval Petroleum Reserve; outer continental shelf local impact assistance; western hemisphere energy policy); Coal and coal technology;Nuclear energy (licensing reform; amendment of PUHCA; and Fast Flux Test Facility)

  2. DOE FY 2010 Budget Request and Recovery Act Funding for Energy Research, Development, Demonstration, and Deployment: Analysis and Recommendations

    Energy Technology Data Exchange (ETDEWEB)

    Anadon, Laura Diaz; Gallagher, Kelly Sims; Bunn, Matthew

    2009-06-01

    The combination of the FY 2010 budget request for the Department of Energy (DOE) and the portion of the American Recovery and Reinvestment Act of 2009 (ARRA) funds likely to be available in 2010 would (assuming that they would be split evenly between FY 2010 and FY 2011) result in a doubling in funding available for energy research, development, and deployment (ERD and D) from $3.6 billion in FY 2009 to $7.2 billion in FY 2010. Without the stimulus funds, DOE ERD and D investments in FY 2010 would decrease very slightly when compared to FY 2009. Excluding the $7.5 billion for the Advanced Technology Vehicles Manufacturing Loans in FY 2009, the FY 2010 budget request for deployment represents a 33 percent decrease from the FY 2009 levels from $520 million to $350 million. This decrease is largely due to the large amounts of funds appropriated in ARRA for DOE deployment programs, or $23.6 billion, which are three times greater than those appropriated in the FY 2009 budget. These very substantial funding amounts, coupled with the broad range of institutional innovations the administration is putting in place and movement toward putting a price on carbon emissions, will help accelerate innovation for a broad range of energy technologies. DOE's Advanced Research Projects Agency-Energy (ARPA-E) and the Energy Innovation Hubs are important initiatives that could contribute to two weak points of the government's energy innovation effort, namely funding high-risk projects in transformational technologies and in companies that have not traditionally worked with the government and strengthening the integration of basic and applied research in priority areas. Increasing the funding for different types of energy storage research, providing some support for exploring opportunities in coal-to-liquids with carbon capture and storage (CCS) and coal-and-biomass-to-liquids with CCS, and reducing funding for fission RD and D are other actions that Congress could take in the

  3. S.1220: This Act may be referred to as the National Energy Security Act of 1991, introduced in the Senate of the United States, One Hundred Second Congress, First Session, June 5, 1991

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    This bill would reduce the Nation's dependence on imported oil and provide for the energy security of the US. The contents of this bill are extensive. The Titles are as follows: Findings and purposes; Definitions; Corporate average fuel economy; Fleets and alternative fuels; Renewable energy; Energy efficiency; Oil and gas leasing in the Arctic National Wildlife Refuge; Advanced nuclear reactor commercialization; Nuclear reactor licensing; Uranium; Natural gas; Outer continental shelf; Research, development, demonstration and commercialization activities; Coal, coal technology, and electricity; Public Utility Holding Company Act reform; and Strategic petroleum reserve

  4. Voluntary reporting of greenhouse gases under Section 1605(b) of the Energy Policy Act of 1992: General Guidelines

    International Nuclear Information System (INIS)

    1994-10-01

    Because of concerns with the growing threat of global climate change from increasing emissions of greenhouse gases, Congress authorized a voluntary program for the public to report achievements in reducing those gases. This document offers guidance on recording historic and current greenhouse gas emissions, emissions reductions, and carbon sequestration. Under the Energy Policy Act (EPAct) reporters will have the opportunity to highlight specific achievements. If you have taken actions to lessen the greenhouse gas effect, either by decreasing greenhouse gas emissions or by sequestering carbon, the Department of Energy (DOE) encourages you to report your achievements under this program. The program has two related, but distinct parts. First, the program offers you an opportunity to report your annual emissions of greenhouse gases. Second, the program records your specific projects to reduce greenhouse gas emissions and increase carbon sequestration. Although participants in the program are strongly encouraged to submit reports on both, reports on either annual emissions or emissions reductions and carbon sequestration projects will be accepted. These guidelines and the supporting technical documents outline the rationale for the program and approaches to analyzing emissions and emissions reduction projects. Your annual emissions and emissions reductions achievements will be reported

  5. The new duty of care for nuclear power plant operators in Sec. 9a subpara. 2a AtG; Zur neuen Sorgepflicht der Kraftwerksbetreiber gem. paragraph 9a Abs. 2a AtG

    Energy Technology Data Exchange (ETDEWEB)

    Posser, Herbert [Freshfields Bruckhaus Deringer LLP, Duesseldorf (Germany)

    2014-07-15

    The new stipulation in Sec. 9a subpara. 2a AtG - pursuant to which operators of nuclear power plants are no longer entitled to use the interim storage facility in Gorleben for radioactive waste stemming from the reprocessing plants in Sellafield and La Hague, but have to establish further capacities in their own facilities for spent nuclear fuels at the site of the power plants - is illegal under constitutional law. It imposes an unproportional burden on the plant operators as well as on GNS, and infringes property rights without pursuing a legitimate purpose. (orig.)

  6. The Clean Air Act Amendments of 1990: Opportunities for Promoting Renewable Energy; Final Report: December 11, 2000

    Energy Technology Data Exchange (ETDEWEB)

    Wooley, D.R.; Morss, E.M. (Young, Sommer, Ward, Ritzenberg, Wooley, Baker and Moore, LLC, Albany, New York)

    2001-01-08

    This report explores key aspects of the intersection between the nation's clean air and energy goals and proposes alternatives for encouraging renewable energy in the context of the federal Clean Air Act (CAA). As with most environmental statutes enacted in the early 1970s, the 1970 CAA embraced a somewhat rigid ''command-and-control'' approach to achieving its clean air goals. Although effective, this approach has been criticized for discouraging creative and cost-effective solutions to reducing air emissions. In response to this concern, Congress included the first significant market-based program to address an environmental problem-in this case, acid rain caused by sulfur dioxide (SO2) emissions from power plants-in the 1990 CAA Amendments. This program prompted the federal government and various state governments to pursue other market-based programs to address air pollution problems. Ten years have elapsed since the passage of the 1990 CAA Amendments, so the time is ripe to consider expanding opportunities for renewable energy development in the reform of clean air policies. A significant potential for renewables exists in conjunction with international efforts to reduce emissions of greenhouse gases (GHG), including CO2. Unfortunately, Congressional opposition to international GHG reduction agreements makes it difficult to develop GHG emission-reduction programs, including a cap-and-trade alternative, that would enable the renewables industry to harness this potential. The renewable industry can, however, track developments both nationally and internationally to ensure that the programs developed adequately address renewables.

  7. Uniparental mitochondrial DNA inheritance is not affected in Ustilago maydis Δatg11 mutants blocked in mitophagy.

    Science.gov (United States)

    Wagner-Vogel, Gaby; Lämmer, Frauke; Kämper, Jörg; Basse, Christoph W

    2015-02-06

    Maternal or uniparental inheritance (UPI) of mitochondria is generally observed in sexual eukaryotes, however, the underlying mechanisms are diverse and largely unknown. Recently, based on the use of mutants blocked in autophagy, it has been demonstrated that autophagy is required for strict maternal inheritance in the nematode Caenorhabditis elegans. Uniparental mitochondrial DNA (mtDNA) inheritance has been well documented for numerous fungal species, and in particular, has been shown to be genetically governed by the mating-type loci in the isogamous species Cryptococcus neoformans, Phycomyces blakesleeanus and Ustilago maydis. Previously, we have shown that the a2 mating-type locus gene lga2 is decisive for UPI during sexual development of U. maydis. In axenic culture, conditional overexpression of lga2 triggers efficient loss of mtDNA as well as mitophagy. To assess a functional relationship, we have investigated UPI in U. maydis Δatg11 mutants, which are blocked in mitophagy. This study has revealed that Δatg11 mutants are not affected in pathogenic development and this has allowed us to analyse UPI under comparable developmental conditions between mating-compatible wild-type and mutant strain combinations. Explicitly, we have examined two independent strain combinations that gave rise to different efficiencies of UPI. We demonstrate that in both cases UPI is atg11-independent, providing evidence that mitophagy is not critical for UPI in U. maydis, even under conditions of strict UPI. Until now, analysis of a role of mitophagy in UPI has not been reported for microbial species. Our study suggests that selective autophagy does not contribute to UPI in U. maydis, but is rather a consequence of selective mtDNA elimination in response to mitochondrial damage.

  8. Autophagy Facilitates Metadherin-Induced Chemotherapy Resistance Through the AMPK/ATG5 Pathway in Gastric Cancer

    Directory of Open Access Journals (Sweden)

    Guoqing Pei

    2018-04-01

    Full Text Available Background/Aims: Metadherin (MTDH is overexpressed in some malignancies and enhances drug resistance; however, its role in gastric cancer (GC and the underlying mechanisms remain largely unexplored. Here, we explore the mechanism by which MTDH induces drug resistance in GC. Methods: We analysed the level of MTDH in GC and adjacent normal gastric mucosal tissues by real-time quantitative PCR (q-PCR. We also analysed the level of autophagy by western blot analysis, confocal microscopy, and transmission electron microscopy after MTDH knockdown and overexpression, and examined fluorouracil (5-FU resistance by Cell Counting Kit-8 at the same time. Finally, GC patient-derived xenograft tumours were used to demonstrate 5-FU resistance. An AMPK pathway inhibitor was applied to determine the molecular mechanisms of autophagy. Results: MTDH expression was significantly increased in the GC specimens compared with that in the adjacent normal gastric mucosal tissues. Further study showed a positive correlation between the expression level of MTDH and 5-FU resistance. MTDH overexpression in MKN45 cells increased the levels of P-glycoprotein (P-gp and promoted 5-FU resistance, while inhibition of MTDH showed the opposite result. The simultaneous inhibition of autophagy and overexpression of MTDH decreased the levels of P-gp and inhibited 5-FU resistance. Moreover, MTDH induced AMPK phosphorylation, regulated ATG5 expression, and finally influenced autophagy, suggesting that MTDH may activate autophagy via the AMPK/ATG5 signalling pathway. Our findings reveal a unique mechanism by which MTDH promotes GC chemoresistance and show that MTDH is a potential target for improved chemotherapeutic sensitivity and GC patient survival. Conclusions: MTDH-stimulated cancer resistance to 5-FU may be mediated through autophagy activated by the AMPK/ATG5 pathway in GC.

  9. Opposite Effects of Two Human ATG10 Isoforms on Replication of a HCV Sub-genomic Replicon Are Mediated via Regulating Autophagy Flux in Zebrafish

    Directory of Open Access Journals (Sweden)

    Yu-Chen Li

    2018-04-01

    Full Text Available Autophagy is a host mechanism for cellular homeostatic control. Intracellular stresses are symptoms of, and responses to, dysregulation of the physiological environment of the cell. Alternative gene transcription splicing is a mechanism potentially used by a host to respond to physiological or pathological challenges. Here, we aimed to confirm opposite effects of two isoforms of the human autophagy-related protein ATG10 on an HCV subgenomic replicon in zebrafish. A liver-specific HCV subreplicon model was established and exhibited several changes in gene expression typically induced by HCV infection, including overexpression of several HCV-dependent genes (argsyn, leugpcr, rasgbd, and scaf-2, as well as overexpression of several ER stress related genes (atf4, chop, atf6, and bip. Autophagy flux was blocked in the HCV model. Our results indicated that the replication of the HCV subreplicon was suppressed via a decrease in autophagosome formation caused by the autophagy inhibitor 3MA, but enhanced via dysfunction in the lysosomal degradation caused by another autophagy inhibitor CQ. Human ATG10, a canonical isoform in autophagy, facilitated the amplification of the HCV-subgenomic replicon via promoting autophagosome formation. ATG10S, a non-canonical short isoform of the ATG10 protein, promoted autophagy flux, leading to lysosomal degradation of the HCV-subgenomic replicon. Human ATG10S may therefore inhibit HCV replication, and may be an appropriate target for future antiviral drug screening.

  10. Interleukin-6 downregulated vascular smooth muscle cell contractile proteins via ATG4B-mediated autophagy in thoracic aortic dissection.

    Science.gov (United States)

    An, Zhao; Qiao, Fan; Lu, Qijue; Ma, Ye; Liu, Yang; Lu, Fanglin; Xu, Zhiyun

    2017-12-01

    Interleukin-6 (IL-6) overexpression played an important role in the pathogenesis of thoracic aortic dissection (TAD). Our previous study found enhanced autophagy accompanying with contractile proteins α smooth muscle actin (α-SMA) and smooth muscle 22α (SM22α) degradation in TAD aortic vascular smooth muscle cells (VSMCs). Autophagy is an important way for intracellular proteins degradation, while IL-6 has been found as a contributing factor of autophagy in some cancers. These indicated IL-6 might contribute to the occurrence of TAD by promoting autophagy-induced contractile proteins degradation, which has not been investigated. The aim of the present study is to verify this hypothesis and investigate the mechanism of it. We collected 10 TAD and 10 control aortic specimens from patients underwent TAD surgical repair and coronary artery bypass grafting, respectively. Quantitative real-time polymerase chain reaction was used to detect mRNA expression. Protein expression level was assessed by enzyme-linked immunosorbent assay, western blot, and immunohistochemistry. Microtubule-associated protein 1 light chain 3 beta overexpression adenovirus with green and red fluorescent protein tags and transmission electron microscopy were used to detect autophagy level in VSMCs. 3-Methyladenine (3-MA) and chloroquine were used to block autophagy in human VSMCs. Experiment results showed that the expression of IL-6 was significantly increased accompanying with up-regulated autophagy in TAD aortic wall compared with controls. In vitro results showed that IL-6 stimulation decreased the expression of VSMCs contractile proteins α-SMA and SM22α accompanying with up-regulated autophagy. Blocking autophagy with 3-MA or chloroquine inhibited IL-6 induced α-SMA and SM22α degradation. Further investigation showed that autophagy-related 4B cysteine peptidase (ATG4B) was significantly overexpressed in TAD aortic wall and played important role in IL-6 induced autophagy up

  11. The new duty of care for nuclear power plant operators in Sec. 9a subpara. 2a AtG

    International Nuclear Information System (INIS)

    Posser, Herbert

    2014-01-01

    The new stipulation in Sec. 9a subpara. 2a AtG - pursuant to which operators of nuclear power plants are no longer entitled to use the interim storage facility in Gorleben for radioactive waste stemming from the reprocessing plants in Sellafield and La Hague, but have to establish further capacities in their own facilities for spent nuclear fuels at the site of the power plants - is illegal under constitutional law. It imposes an unproportional burden on the plant operators as well as on GNS, and infringes property rights without pursuing a legitimate purpose. (orig.)

  12. Office of Electricity Delivery and Energy Reliability (OE) National Energy Technology Laboratory (NETL) American Recovery and Reinvestment Act 2009 United States Department of Energy

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Mohit [Seeo, Incorporated, Hayward, CA (United States); Grape, Ulrik [Seeo, Incorporated, Hayward, CA (United States)

    2014-07-29

    The purpose of this project was for Seeo to deliver the first ever large-scale or grid-scale prototype of a new class of advanced lithium-ion rechargeable batteries. The technology combines unprecedented energy density, lifetime, safety, and cost. The goal was to demonstrate Seeo’s entirely new class of lithium-based batteries based on Seeo’s proprietary nanostructured polymer electrolyte. This technology can enable the widespread deployment in Smart Grid applications and was demonstrated through the development and testing of a 10 kilowatt-hour (kWh) prototype battery system. This development effort, supported by the United States Department of Energy (DOE) enabled Seeo to pursue and validate the transformational performance advantages of its technology for use in grid-tied energy storage applications. The focus of this project and Seeo’s goal as demonstrated through the efforts made under this project is to address the utility market needs for energy storage systems applications, especially for residential and commercial customers tied to solar photovoltaic installations. In addition to grid energy storage opportunities Seeo’s technology has been tested with automotive drive cycles and is seen as equally applicable for battery packs for electric vehicles. The goals of the project were outlined and achieved through a series of specific tasks, which encompassed materials development, scaling up of cells, demonstrating the performance of the cells, designing, building and demonstrating a pack prototype, and providing an economic and environmental assessment. Nearly all of the tasks were achieved over the duration of the program, with only the full demonstration of the battery system and a complete economic and environmental analysis not able to be fully completed. A timeline over the duration of the program is shown in figure 1.

  13. International Fusion Energy Act of 1993. Hearing before the Committee on Energy and Natural Resources, United States Senate, One Hundred Third Congress, First Session on S. 646, May 6, 1993

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    The text of the bill, International Fusion Energy Act of 1993, is included along with statements from the following: B. Bradley, Senator, NJ; Dr. J. Decker, DOE Office of Energy Research; J. Gavin; Dr. R. Hirsch, Electric Power Research Institute; B. Johnston, Senator, LA; Dr. D. Overskei, General Atomics; Dr. P. Rebut, International Thermonuclear Experimental Reactor; M. Wallop, Senator, WY

  14. The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients

    DEFF Research Database (Denmark)

    Metzger, Silke; Walter, Carolin; Riess, Olaf

    2013-01-01

    The cause of Huntington disease (HD) is a polyglutamine repeat expansion of more than 36 units in the huntingtin protein, which is inversely correlated with the age at onset of the disease. However, additional genetic factors are believed to modify the course and the age at onset of HD. Recently......, we identified the V471A polymorphism in the autophagy-related gene ATG7, a key component of the autophagy pathway that plays an important role in HD pathogenesis, to be associated with the age at onset in a large group of European Huntington disease patients. To confirm this association in a second...... independent patient cohort, we analysed the ATG7 V471A polymorphism in additional 1,464 European HD patients of the "REGISTRY" cohort from the European Huntington Disease Network (EHDN). In the entire REGISTRY cohort we could not confirm a modifying effect of the ATG7 V471A polymorphism. However, analysing...

  15. Impact of T300A Variant of ATG16L1 on Antibacterial Response, Risk of Culture Positive Infections, and Clinical Course of Crohn's Disease

    DEFF Research Database (Denmark)

    Salem, Mohammad; Nielsen, Ole Haagen; Nys, Kris

    2015-01-01

    OBJECTIVES: Autophagy-related 16-like 1 (ATG16L1) deficiency leads to impaired cellular autophagy and bacterial degradation as well as an altered cytokine production. The single-nucleotide polymorphism rs2241880 (T300A) is associated with an increased risk for Crohn's disease (CD). ATG16L1...... polymorphisms could therefore have an impact on the risk of infectious complications and disease course in CD. We examined the impact of the T300A genotype on the antibacterial response toward a panel of pathogenic bacteria in vitro, as well as clinical infectious complications in vivo and the disease course...... risk variant, AG heterozygous variant, respectively). The median duration of disease was 128 months (range, 30-175). The cumulative follow-up of this cohort was 2,366 patient-years. ATG16L1 gene variations interfered with the production of IL-1β, which was significantly increased in PBMCs from GG...

  16. The Energy Policy Act of 1992 and Executive Order 13149: Proposed compliance strategies and process improvements for federal agencies

    International Nuclear Information System (INIS)

    Helwig, Michael; Deason, Jonathan P.

    2007-01-01

    Under the Energy Policy Act of 1992 (EPAct), 75 percent of Light Duty Vehicle acquisitions by federal agencies must be Alternative Fuel Vehicles (AFVs). EPAct's intent was to reduce United States reliance on oil imports, with federal agencies assuming a leadership role in acquiring AFVs and using alternative fuel in those AFVs. Executive Order (E.O.) 13149, issued in 2000, required federal agencies to reduce petroleum consumption 20 percent relative to a 1999 baseline and use alternative fuels the majority of the time in their AFVs by 2005. Most federal agencies met the EPAct 75 percent acquisition requirement in 2004, however, most will not achieve the petroleum reduction and alternative fuel use requirements. Frequently, federal agencies acquire the relatively expensive AFVs and then fuel those vehicles with gasoline. Besides wasting taxpayer dollars, this approach does not meet the intent of EPAct. It was surmised that federal agencies lack an objective, quantitative methodology for AFV acquisitions and Executive Order 13149 compliance. Several types of optimization models were constructed, using the United States Navy as a test case, for models focusing on EPAct and/or E.O. 13149 compliance. Results of a tiered set of models indicate there are efficiencies that federal agencies could take advantage of when developing EPAct and E.O. 13149 compliance strategies that are not currently being exploited

  17. Alkem instruction: Legal relief of a Federal State against instructions under the Atomic Energy Act issued by the Federal Government

    International Nuclear Information System (INIS)

    Steinberg, R.

    1987-01-01

    The German Federal Minister for the Environment, Protection of Nature, and Reactor Safety instructed the Hesse State Minister for Economics and Technology to grant the applications filed by Alkem GmbH for a first partial permit of the construction and operation of a fuel element factory, and to grant it on the basis of a draft working document discussed between the two ministries. The new feature is the refusal of the Hesse State Minister to follow these instructions. This has given rise to a conflict between the State and Federal Governments. The article deals with one aspect of the multifaceted legal controversy, i.e., the question of the possibilities of legal relief open to a Federal State against an instruction under the Atomic Energy Act issued by the Federal Government. First, the rank of this instruction within the scope of administration on behalf of the Federal Government will be discussed. Next, the central problem of the preconditions under which an instruction may violate rights of a Federal State will be investigated. Finally, the possibilities of litigation will be briefly referred to. (orig./HP) [de

  18. Act No 1860 of 31 December 1962 of the President of the Republic on the peaceful uses of nuclear energy as amended at 10 May 1975

    International Nuclear Information System (INIS)

    1975-01-01

    This English and French translation of Act No 1860 on the Peaceful Uses of Nuclear Energy incorporates and indicates the successive amendments made since the Act was published in 1962. Act No 1860 is a Basic Act covering all nuclear activities in Italy (regime for ores and nuclear materials, construction and operation of nuclear installations, third party liability, patents, penal provisions...). Given its general character it has been the subject of numerous implementing regulations. The most important, and most recent amendment, is emboided in a Decree of the President of the Republic dated 10th May 1975 which covers the provisions of the third party liability of operators of nuclear installations; its purpose is to embody in Italian domestic law the principles of the Paris Convention and Brussels Supplementary Convention on nuclear third party liability whose ratification was approved by Parliament in 1974 [fr

  19. Perioperative single high dose ATG-Fresenius S administration as induction immunosuppressive therapy in cadaveric renal transplantation--preliminary results.

    Science.gov (United States)

    Samsel, R; Chmura, A; Włodarczyk, Z; Wyzgał, J; Cieciura, T; Lagiewska, B; Pliszczyński, J; Korczak, G; Lazowski, T; Paczek, L; Wałaszewski, J; Lao, M; Rowiński, W

    1999-01-01

    Monoclonal and polyclonal antilymphocyte antibodies have been used successfully in organ transplantation as induction therapy and in the treatment of acute graft rejection. Used for induction the medication is generally given for the first 7-10 days. The aim of this study was to assess the safety and efficacy of single high dose (9 mg/kg) ATG Fresenius S given perioperatively, before revascularization, to kidney allograft recipients. During last twelve months seventy six, first cadaveric kidney adult recipients were included into the study in two centers (center A-64, center B-12). All patients received triple drug immunosuppression (Neoral, steroids and Cellcept which was replaced by azathioprine after 4 months), and were randomized to receive ATG or not. The follow-up period ranged from 1 month up to 1 year. The preliminary results are very promising, the rejection rate in bolus group was significantly lower than in control. No significant side effects or serious adverse events in both groups were observed.

  20. Standard Compliance: Guidelines to Help State and Alternative Fuel Provider Fleets Meet Their Energy Policy Act Requirements, 10 CFR Part 490 (Book)

    Energy Technology Data Exchange (ETDEWEB)

    2014-03-01

    This guidebook addresses the primary requirements of the Alternative Fuel Transportation Program to help state and alternative fuel provider fleets comply with the Energy Policy Act via the Standard Compliance option. It also addresses the topics that covered fleets ask about most frequently.

  1. Decree of 8 October 1969, Stb. 471, concerning the implementation of Sections 13 and 14 of the Nuclear Energy Act (Fissionable Materials and Ores (Registration))

    International Nuclear Information System (INIS)

    1969-01-01

    This Decree lays down the system for registration and notification of fissionable materials and ores in accordance with the Nuclear Energy Act. The register must list the quantities of fissionable materials and ores available in the Netherlands and their location. This procedure applies only to materials and ores subject to licensing. (NEA) [fr

  2. Decree pf 16 July 1970, no.46, Stcrt. 140, concerning the implementation of Section 22, paragraph 4, of the Nuclear Energy Act

    International Nuclear Information System (INIS)

    1970-01-01

    Under the Nuclear Energy Act, any fissionable materials or ores held without due authorization shall be seized and handed over to an establishment designated by Decree. This Decree designates the establishment to which such materials or ores shall be transferred. (NEA) [fr

  3. Experiences with interpretation and application of the German Atomic Energy Act for the German research reactors in Geesthacht FRG-1 and FRG-2

    International Nuclear Information System (INIS)

    Krull, W.

    1980-01-01

    The German research reactors FRG-1 and FRG-2 have passed different types of licensing procedures in the past years. It is reported about the experiences we have got in the interpretation and application of section 7 of the German Atomic Energy Act. Following these experiences an estimation is done for the licensing procedure for the reduction of the uranium enrichment. (orig.) [de

  4. Health impact assessment of Ontario's green energy and green economy act. The roles of environmental informatics in sustainability

    Energy Technology Data Exchange (ETDEWEB)

    Rattle, Robert

    2013-07-01

    Renewable energy received a boost in Ontario, Canada with the Green Energy and Green Economy Act (GEGEA), ushering in a new Feed-in-Tariff (FIT) program modelled on programs from Germany, Spain, Denmark and other jurisdictions. Information about lessons learned elsewhere has clearly benefited the Ontario experience. Part of the Ontario program included streamlining the impact assessment process to facilitate the swift development of provincial renewable energy capacities. In this context, the GEGEA has been remarkably successful, generating renewable energy sector capacities, resources, projects and their spin-off benefits in Ontario, along with more sustainable electricity system. Environmentalists along with industry continue to laud the benefits of renewable energy and the GEGEA, and with good reason. Renewable energy generation in Ontario has grown from to 2 per cent in 2012 and is expected to reach 10 per cent in 2013. (orig.)

  5. Comprehensive Energy Assessment: EE and RE Project Optimization Modeling for United States Pacific Command (USPACOM) American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance

    Energy Technology Data Exchange (ETDEWEB)

    Brigantic, Robert T.; Papatyi, Anthony F.; Perkins, Casey J.

    2010-09-30

    This report summarizes a study and corresponding model development conducted in support of the United States Pacific Command (USPACOM) as part of the Federal Energy Management Program (FEMP) American Reinvestment and Recovery Act (ARRA). This research was aimed at developing a mathematical programming framework and accompanying optimization methodology in order to simultaneously evaluate energy efficiency (EE) and renewable energy (RE) opportunities. Once developed, this research then demonstrated this methodology at a USPACOM installation - Camp H.M. Smith, Hawaii. We believe this is the first time such an integrated, joint EE and RE optimization methodology has been constructed and demonstrated.

  6. Air quality impacts of increased use of ethanol under the United States’ Energy Independence and Security Act

    Science.gov (United States)

    Cook, Rich; Phillips, Sharon; Houyoux, Marc; Dolwick, Pat; Mason, Rich; Yanca, Catherine; Zawacki, Margaret; Davidson, Ken; Michaels, Harvey; Harvey, Craig; Somers, Joseph; Luecken, Deborah

    2011-12-01

    Increased use of ethanol in the United States fuel supply will impact emissions and ambient concentrations of greenhouse gases, "criteria" pollutants for which the U. S. EPA sets ambient air quality standards, and a variety of air toxic compounds. This paper focuses on impacts of increased ethanol use on ozone and air toxics under a potential implementation scenario resulting from mandates in the U. S. Energy Independence and Security Act (EISA) of 2007. The assessment of impacts was done for calendar year 2022, when 36 billion gallons of renewable fuels must be used. Impacts were assessed relative to a baseline which assumed ethanol volumes mandated by the first renewable fuels standard promulgated by U. S. EPA in early 2007. This assessment addresses both impacts of increased ethanol use on vehicle and other engine emissions, referred to as "downstream" emissions, and "upstream" impacts, i.e., those connected with fuel production and distribution. Air quality modeling was performed for the continental United States using the Community Multi-scale Air Quality Model (CMAQ), version 4.7. Pollutants included in the assessment were ozone, acetaldehyde, ethanol, formaldehyde, acrolein, benzene, and 1,3-butadiene. Results suggest that increased ethanol use due to EISA in 2022 will adversely increase ozone concentrations over much of the U.S., by as much as 1 ppb. However, EISA is projected to improve ozone air quality in a few highly-populated areas that currently have poor air quality. Most of the ozone improvements are due to our assumption of increases in nitrogen oxides (NO x) in volatile organic compound (VOC)-limited areas. While there are some localized impacts, the EISA renewable fuel standards have relatively little impact on national average ambient concentrations of most air toxics, although ethanol concentrations increase substantially. Significant uncertainties are associated with all results, due to limitations in available data. These uncertainties are

  7. 11{sup th} and 12{sup th} draft laws amending the Atomic Energy Act; Die Gesetzentwuerfe zur elften und zwoelften Aenderung des Atomgesetzes

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Horst

    2010-11-15

    On September 28, 2010, the German Federal Government adopted the energy concept and, in addition, 2 draft amendments to the Atomic Energy Act to assist the coalition groups in the wording. The coalition groups tabled the 2 drafts in the Federal Parliament the same day. The subject of the 11{sup th} amending law is the extended plant life of nuclear power plants, that of the 12{sup th} amending law, the transposition into national law of the EURATOM Safety Directive of June 2009, the re-introduction of expropriation provisions about final storage, and the duty of operators to enhance the safety of existing nuclear power plants. The Federal Government's energy concept contains this statement about nuclear power: An extension for a limited period of time of the plant life of existing nuclear power plants makes a key contribution to ensuring, for an interim period of time, the three energy policy goals of climate protection, economy, and security of supply in Germany. It eases the way into the era of renewable energies, especially by its controlling effect on the price of electricity and by reducing greenhouse gas emissions related to power production.'' The amendment to the Atomic Energy Act, which does not require the consent of the Federal Council, extends the operating life of nuclear power plants by an average of 12 years. The EURATOM Safety Directive must be transposed into national law by July 22, 2011. The draft of a 12{sup th} amendment to the Atomic Energy Act submitted to this end, which also requires no consent of the Federal Council, bases its reasoning on the fact that most of the important requirements in the Directive had already been taken care of in Germany. Under the 12{sup th} amendment to the Atomic Energy Act, the expropriation regulations deemed to be necessary for repository storage, which had been introduced in the 1998 amendment to the Atomic Energy Act and abolished by the opt-out amendment of 2002, are to be reinstated. (orig.)

  8. Energy Efficiency and Renewable Energy Research, Development, and Deployment in Meeting Greenhouse Gas Mitigation Goals. The Case of the Lieberman-Warner Climate Security Act of 2007 (S. 2191)

    Energy Technology Data Exchange (ETDEWEB)

    Showalter, Sharon [OnLocation, Inc./ Energy Systems Consulting, Vienna, VA (United States); Wood, Frances [OnLocation, Inc./ Energy Systems Consulting, Vienna, VA (United States); Vimmerstedt, Laura [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2010-06-01

    The U.S. federal government is considering actions to reduce greenhouse gas emissions. Renewable energy and energy efficiency technologies could help reduce greenhouse gas emissions, so the cost of these technologies could significantly influence the overall cost of meeting greenhouse gas limits. This paper examines the potential benefit of reduced technology cost by analyzing the case of the Lieberman-Warner Climate Security Act of 2007 (S.2191). This act had a goal of reducing national carbon emissions in 2050 to levels 72 percent below 2006 emission levels. In April 2008, the U.S. Department of Energy, Energy Information Administration (EIA) published an analysis of the effects of S.2191 on the U.S. energy sector. This report presents a similar analysis: both analyses examined the impacts of S.2191, and both used versions of the National Energy Modeling System. The analysis reported here used modified technology assumptions to reflect U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy (EERE) program goals. The results show that achieving EERE program goals could reduce the cost of meeting greenhouse gas limits, reduce the cost of renewable electricity generation and biofuels, and reduce energy intensity.

  9. Energy Efficiency and Renewable Energy Research, Development, and Deployment in Meeting Greenhouse Gas Mitigation Goals: The Case of the Lieberman-Warner Climate Security Act of 2007 (S.2191)

    Energy Technology Data Exchange (ETDEWEB)

    Showalter, S.; Wood, F.; Vimmerstedt, L.

    2010-06-01

    The U.S. federal government is considering actions to reduce greenhouse gas emissions. Renewable energy and energy efficiency technologies could help reduce greenhouse gas emissions, so the cost of these technologies could significantly influence the overall cost of meeting greenhouse gas limits. This paper examines the potential benefit of reduced technology cost by analyzing the case of the Lieberman-Warner Climate Security Act of 2007 (S.2191). This act had a goal of reducing national carbon emissions in 2050 to levels 72 percent below 2006 emission levels. In April 2008, the U.S. Department of Energy, Energy Information Administration (EIA) published an analysis of the effects of S.2191 on the U.S. energy sector. This report presents a similar analysis: both analyses examined the impacts of S.2191, and both used versions of the National Energy Modeling System. The analysis reported here used modified technology assumptions to reflect U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy (EERE) program goals. The results show that achieving EERE program goals could reduce the cost of meeting greenhouse gas limits, reduce the cost of renewable electricity generation and biofuels, and reduce energy intensity.

  10. Lipidation of BmAtg8 is required for autophagic degradation of p62 bodies containing ubiquitinated proteins in the silkworm, Bombyx mori.

    Science.gov (United States)

    Ji, Ming-Ming; Lee, Jae Man; Mon, Hiroaki; Iiyama, Kazuhiro; Tatsuke, Tsuneyuki; Morokuma, Daisuke; Hino, Masato; Yamashita, Mami; Hirata, Kazuma; Kusakabe, Takahiro

    2017-10-01

    p62/Sequestosome-1 (p62/SQSTM1, hereafter referred to as p62) is a major adaptor that allows ubiquitinated proteins to be degraded by autophagy, and Atg8 homologs are required for p62-mediated autophagic degradation, but their relationship is still not understood in Lepidopteran insects. Here it is clearly demonstrated that the silkworm homolog of mammalian p62, Bombyx mori p62 (Bmp62), forms p62 bodies depending on its Phox and Bem1p (PB1) and ubiquitin-associated (UBA) domains. These two domains are associated with Bmp62 binding to ubiquitinated proteins to form the p62 bodies, and the UBA domain is essential for the binding, but Bmp62 still self-associates without the PB1 or UBA domain. The p62 bodies in Bombyx cells are enclosed by BmAtg9-containing membranes and degraded via autophagy. It is revealed that the interaction between the Bmp62 AIM motif and BmAtg8 is critical for the autophagic degradation of the p62 bodies. Intriguingly, we further demonstrate that lipidation of BmAtg8 is required for the Bmp62-mediated complete degradation of p62 bodies by autophagy. Our results should be useful in future studies of the autophagic mechanism in Lepidopteran insects. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. AoAtg26, a putative sterol glucosyltransferase, is required for autophagic degradation of peroxisomes, mitochondria, and nuclei in the filamentous fungus Aspergillus oryzae.

    Science.gov (United States)

    Kikuma, Takashi; Tadokoro, Takayuki; Maruyama, Jun-Ichi; Kitamoto, Katsuhiko

    2017-02-01

    Autophagy is a conserved process in eukaryotic cells for degradation of cellular proteins and organelles. In filamentous fungi, autophagic degradation of organelles such as peroxisomes, mitochondria, and nuclei occurs in basal cells after the prolonged culture, but its mechanism is not well understood. Here, we functionally analyzed the filamentous fungus Aspergillus oryzae AoAtg26, an ortholog of the sterol glucosyltransferase PpAtg26 involved in pexophagy in the yeast Pichia pastoris. Deletion of Aoatg26 caused a severe decrease in conidiation and aerial hyphae formation, which is typically observed in the autophagy-deficient A. oryzae strains. In addition, cup-shaped AoAtg8-positive membrane structures were accumulated in the Aoatg26 deletion strain, indicating that autophagic process is impaired. Indeed, the Aoatg26 deletion strain was defective in the degradation of peroxisomes, mitochondria, and nuclei. Taken together, AoAtg26 plays an important role for autophagic degradation of organelles in A. oryzae, which may physiologically contribute to the differentiation in filamentous fungi.

  12. Heat grids today and after the German Renewable Energies Act (EEG). A business segment for the agriculture?; Waermenetze heute und nach dem EEG. Ein Betriebszweig fuer die Landwirtschaft?

    Energy Technology Data Exchange (ETDEWEB)

    Clemens, Dietrich; Billerbeck, Hagen [Treurat und Partner Unternehmensberatungsgesellschaft mbH, Lueneburg (Germany). Abt. ' ' Climate and Energy' '

    2016-08-01

    The development of a centralised and sustainable heat supply through the construction of heat grids offers consumers numerous advantages compared to a decentralised energy supply of residential and commercial properties. Where the migration to centralised heat supply relegates fossil fuels through the long-term incorporation of sustainable renewable energy sources, the projects make an important contribution towards meeting the government's climate protection goals. Heat generation and heat sales from renewable energy sources should be ensured in the long term. In the countryside, biogas plant operators are frequently the initiators of heat grid investments, or they take on the role of supplier for the provision of low-cost CHP heat from cogeneration units. In view of the limited remuneration period under the terms of the German Renewable Energy Act, the clock is ticking for the establishment of a centralised heat supply. This paper presents the advantages and disadvantages of a centralised, sustainable heat supply and additionally considers the flexibi/isation of biogas plants in view of the construction of the heat grid and the associated infrastructure. A focus is placed on the security of supply for customers after the discontinuation of remuneration under the German Renewable Energy Act and on how a competitive heat price from alternative energy sources can continue to be ensured.

  13. H.R. 3593: This act may be cited as the Department of Energy Small Business and Industry Partnership Enhancement Act of 1998, introduced in the House of Representatives, One Hundred Fifth Congress, Second Session, March 30, 1998

    International Nuclear Information System (INIS)

    1998-01-01

    The purposes of this Act are to improve the ability of small businesses, Federal agencies, industry, and universities to work with the contractor-operated facilities of the Department of Energy while ensuring full cost recovery of each contractor-operated facility's expenses incurred in such work; to encourage the contractor-operated facilities to expand their partnerships with universities and industries; and to expand interactions of contractor-operated facilities with small businesses so as to encourage commercial evaluation and development of the science and technology base of the contractor-operated facilities; and provide technical assistance to small businesses

  14. Factors impacting short and long-term kidney graft survival: modification by single intra-operative -high-dose induction with ATG-Fresenius.

    Science.gov (United States)

    Kaden, Jürgen; May, Gottfried; Völp, Andreas; Wesslau, Claus

    2011-01-01

    A majority of recipients benefited from the intra-operative single high-dose induction (HDI) with ATG-Fresenius (ATG-F) still leaving a group of recipients who did not profit from this kind of induction. Therefore the aim of this retrospective analysis was 1st to identify the risk factors impacting short and long-term graft survival, and 2nd to assess the efficacy of this type of induction in kidney graft recipients with or without these risk factors. A total of 606 recipients receiving two different immunosuppressive treatment regimens (1st: Triple drug therapy [TDT, n=196] consisting mainly of steroids, azathioprine and cyclosporine; 2nd: TDT + 9 mg/kg ATG-F intra-operatively [HDI, n=410]) were included in this analysis and grouped according to their kidney graft survival time (short GST: ≤1 yr, n=100 and long GST: >5 yrs, n=506). The main risk factors associated with a shortened graft survival were pre-transplant sensitization, re-transplantation, rejections (in particular vascular or mixed ones) and the necessity of a long-term anti-rejection therapy. Adding ATG-F single high dose induction to TDT was more efficient in prolonging kidney graft survival than TDT alone not only in recipients without any risk factors (p<0.005) but also in recipients with at least one risk factor (p<0.021). Only in 4.6% of recipients having two or more risk factors this effect could not be demonstrated. The intra-operative single high-dose induction with ATG-F significantly improves the kidney graft survival in recipients with or without risk factors and can therefore be recommended.

  15. Effect of a single intraoperative high-dose ATG-Fresenius on delayed graft function in donation after cardiac-death donor renal allograft recipients: a randomized study.

    Science.gov (United States)

    van den Hoogen, Martijn W F; Kho, Marcia M L; Abrahams, Alferso C; van Zuilen, Arjan D; Sanders, Jan-Stephan; van Dijk, Marja; Hilbrands, Luuk B; Weimar, Willem; Hoitsma, Andries J

    2013-04-01

    Reducing the incidence of delayed graft function after transplant with donation after cardiac death donor renal allografts would facilitate managing recipients during their first weeks after a transplant. To reduce this incidence, in most studies, induction therapy with depleting anti-T-lymphocyte antibodies is coupled with a reduction of the dosage of the calcineurin inhibitor. The separate effect of anti-T-cell therapy on the incidence and duration of delayed graft function is therefore difficult to assess. We performed a randomized study to evaluate the effect of a single intraoperative high-dose of anti-T-lymphocyte immunoglobulin (ATG)-Fresenius (9 mg/kg body weight) on the incidence of delayed graft function. Eligible adult recipients of a first donation after cardiac death donor renal allograft were randomly assigned to ATG-Fresenius or no induction therapy. Maintenance immunosuppression consisted of tacrolimus, in an unadjusted dose, mycophenolate mofetil, and steroids. The study was prematurely terminated because of a lower-than-anticipated inclusion rate. Baseline characteristics were comparable in the ATG-Fresenius group (n=28) and the control group (n=24). Twenty-two patients in the ATG-Fresenius group (79%) had delayed graft function, compared with 13 in the control group (54%; P = .06). Allograft and patient survival were comparable in both groups. Serious adverse events occurred more frequently in the ATG-Fresenius group than they did in the control group (57% vs 29%; P Fresenius in donation after cardiac death donor renal allograft recipients, followed by triple immunosuppression with an unadjusted tacrolimus dose, seems ineffective to reduce the incidence of delayed graft function. Moreover, this was associated with a higher rate of serious adverse events (EudraCT-number, 2007-000210-36.).

  16. Analysis of recently enacted national energy legislation and the Clean Air Act Amendments of 1990 as related to Decontamination and Decommissioning at Federal, State, and private facilities

    International Nuclear Information System (INIS)

    1994-01-01

    This report is a summary of an analysis of recently enacted national energy legislation and the Clean Air Act Amendments of 1990 as related to Decontamination and Decommissioning (D ampersand D) at Federal, State and private facilities. It is submitted pursuant to Appendix A of subcontract 9-X62-0785E-1, dated July 27, 1992, between the Regents of the University of California and Van Ness, Feldman ampersand Curtis

  17. Nuclear Regulatory Authority Act, 2015 (Act 895)

    International Nuclear Information System (INIS)

    2015-04-01

    An Act to establish a Nuclear Regulatory Authority in Ghana. This Act provides for the regulation and management of activities and practices for the peaceful use of nuclear material or energy, and to provide for the protection of persons and the environment against the harmful effects of radiation; and to ensure the effective implementation of the country’s international obligations and for related matters. This Act replaced the Radiation Protection Instrument, of 1993 (LI 1559).

  18. The end of the nuclear power generation. On the recommendations of the ethics committee according to the 13th amendment to the Atomic Energy Act

    International Nuclear Information System (INIS)

    Becker, Peter

    2011-01-01

    With the 13th Amendment to the Atomic Energy Act the nuclear consequences of the earthquake disaster in Japan will result in an end to nuclear power generation in Germany. Here, the legislature resorted to unusual methods. For the first time, the legislature received advices from the ''ethics committee reliable energy supply''. This Ethics Commission adopted its recommendations ''on behalf of the Chancellor'' in the period from 4th April to 28th May, 2011. The understanding of this development, its epochal character and speed of decision-making requires an excursion into the economic history and the establishment of nuclear power generation with their legal protection.

  19. Radioactive Substances Act 1960

    International Nuclear Information System (INIS)

    1960-01-01

    This Act regulates the keeping and use of radioactive material and makes provision for the disposal and storage of radioactive waste in the United Kingdom. It provides for a licensing system for such activities and for exemptions therefrom, in particular as concerns the United Kingdom Atomic Energy Authority. The Act repeals Section 4(5) of the Atomic Energy Authority Act, 1954 which made temporary provision for discharge of waste on or from premises occupied by the Authority. (NEA) [fr

  20. Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti-T-cell globulin ATG-Fresenius.

    Science.gov (United States)

    Socié, Gérard; Schmoor, Claudia; Bethge, Wolfgang A; Ottinger, Hellmut D; Stelljes, Matthias; Zander, Axel R; Volin, Liisa; Ruutu, Tapani; Heim, Dominik A; Schwerdtfeger, Rainer; Kolbe, Karin; Mayer, Jiri; Maertens, Johan A; Linkesch, Werner; Holler, Ernst; Koza, Vladimir; Bornhäuser, Martin; Einsele, Hermann; Kolb, Hans-Jochem; Bertz, Hartmut; Egger, Matthias; Grishina, Olga; Finke, Jürgen

    2011-06-09

    Previous randomized graft-versus-host disease (GVHD)-prophylaxis trials have failed to demonstrate reduced incidence and severity of chronic GVHD (cGVHD). Here we reanalyzed and updated a randomized phase 3 trial comparing standard GVHD prophylaxis with or without pretransplantation ATG-Fresenius (ATG-F) in 201 adult patients receiving myeloablative conditioning before transplantation from unrelated donors. The cumulative incidence of extensive cGVHD after 3 years was 12.2% in the ATG-F group versus 45.0% in the control group (P < .0001). The 3-year cumulative incidence of relapse and of nonrelapse mortality was 32.6% and 19.4% in the ATG-F group and 28.2% and 33.5% in the control group (hazard ratio [HR] = 1.21, P = .47, and HR = 0.68, P = .18), respectively. This nonsignificant reduction in nonrelapse mortality without increased relapse risk led to an overall survival rate after 3 years of 55.2% in the ATG-F group and 43.3% in the control group (HR = 0.84, P = .39, nonsignificant). The HR for receiving immunosuppressive therapy (IST) was 0.31 after ATG-F (P < .0001), and the 3-year probability of survival free of IST was 52.9% and 16.9% in the ATG-F versus control, respectively. The addition of ATG-F to standard cyclosporine, methotrexate GVHD prophylaxis lowers the incidence and severity of cGVHD, and the risk of receiving IST without raising the relapse rate. ATG-F prophylaxis reduces cGVHD morbidity.

  1. Opportunities for Energy Development in Water Conduits: A Report Prepared in Response to Section 7 of the Hydropower Regulatory Efficiency Act of 2013

    Energy Technology Data Exchange (ETDEWEB)

    Sale, Michael J. [BCS, Incorporated, Laurel, MD (United States); Bishop, Norman A. [Knight Piesold, Chicago, IL (United States); Reiser, Sonya L. [Knight Piesold, Chicago, IL (United States); Johnson, Kurt [Telluride Energy LLC, Grand Junction, CO (United States); Bailey, Andrea C. [BCS, Incorporated, Laurel, MD (United States); Frank, Anthony [BCS, Incorporated, Laurel, MD (United States); Smith, Brennan T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Environmental Sciences Division

    2014-09-01

    In Section 7 of the Hydropower Regulatory Efficiency Act (HREA) of 2013 (P.L. 113-23), Congress directed the U.S. Department of Energy (DOE) to prepare an analysis of conduit hydropower opportunities available in the United States and to present case studies that describe the potential energy generation from these types of hydropower projects. Those analyses have been included in a new DOE report to Congress, and this ORNL/TM provides additional technical details supporting that report. Conduit hydropower offers important new ways to enhance renewable energy portfolios in the United States, as well as to increase the energy efficiency of water delivery systems. Conduit hydropower projects are constructed on existing water-conveyance structures, such as irrigation canals or pressurized pipelines that deliver water to municipalities, industry, or agricultural water users. Although water conveyance infrastructures are usually designed for non-power purposes, new renewable energy can often be harvested from them without affecting their original purpose and without the need to construct new dams or diversions. Conduit hydropower differs from more conventional hydropower development in that it is generally not located on natural rivers or waterways and therefore does not involve the types of environmental impacts that are associated with hydropower. The addition of hydropower to existing water conduits can provide valuable new revenue sources from clean, renewable energy. The new energy can be used within the existing water distribution systems to offset other energy demands, or it can be sold into regional transmission systems.

  2. Genome-wide analysis of autophagy-associated genes in foxtail millet (Setaria italica L.) and characterization of the function of SiATG8a in conferring tolerance to nitrogen starvation in rice.

    Science.gov (United States)

    Li, Weiwei; Chen, Ming; Wang, Erhui; Hu, Liqin; Hawkesford, Malcolm J; Zhong, Li; Chen, Zhu; Xu, Zhaoshi; Li, Liancheng; Zhou, Yongbin; Guo, Changhong; Ma, Youzhi

    2016-10-12

    Autophagy is a cellular degradation process that is highly evolutionarily-conserved in yeast, plants, and animals. In plants, autophagy plays important roles in regulating intracellular degradation and recycling of amino acids in response to nutrient starvation, senescence, and other environmental stresses. Foxtail millet (Setaria italica) has strong resistance to stresses and has been proposed as an ideal material for use in the study of the physiological mechanisms of abiotic stress tolerance in plants. Although the genome sequence of foxtail millet (Setaria italica) is available, the characteristics and functions of abiotic stress-related genes remain largely unknown for this species. A total of 37 putative ATG (autophagy-associated genes) genes in the foxtail millet genome were identified. Gene duplication analysis revealed that both segmental and tandem duplication events have played significant roles in the expansion of the ATG gene family in foxtail millet. Comparative synteny mapping between the genomes of foxtail millet and rice suggested that the ATG genes in both species have common ancestors, as their ATG genes were primarily located in similar syntenic regions. Gene expression analysis revealed the induced expression of 31 SiATG genes by one or more phytohormone treatments, 26 SiATG genes by drought, salt and cold, 24 SiATG genes by darkness and 25 SiATG genes by nitrogen starvation. Results of qRT-PCR showing that among 37 SiATG genes, the expression level of SiATG8a was the highest after nitrogen starvation treatment 24 h, suggesting its potential role in tolerance to nutrient starvation. Moreover, the heterologous expression of SiATG8a in rice improved nitrogen starvation tolerance. Compared to wild type rice, the transgenic rice performed better and had higher aboveground total nitrogen content when the plants were grown under nitrogen starvation conditions. Our results deepen understanding about the characteristics and functions of ATG genes in

  3. Price-Anderson Act Amendments Act of 1985. Hearing before the Subcommittee on Energy Research and Development of the Committee on Energy and Natural Resources, United States Senate, Ninety-Ninth Congress, First Session on S. 1225, June 25, 1985

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    A hearing on S. 1225, which clarifies and expands insurance coverage under the Price-Anderson Act, brought testimony from Nuclear Regulatory Commissioners, representatives of several states and power companies, insurance underwriters, and DOE. At issue was DOE's recommended changes to limit liability and to include commercial and defense waste facilities under the provisions for special coverage in event of an extraordinary nuclear occurrence. DOE's request was to update, but not to radically change the Price-Anderson Act. Utilities and insurance underwriters objected to policies which would impose heavier financial burdens on the nuclear power industry by requiring insurance pools. Witnesses noted the adverse effects of unlimited liability as well as the need to insure the health of the insurance industry in conjunction with promoting nuclear power. The testimony of 17 witnesses and additional responses for the record follows the text of S. 1225

  4. A Look Back at the Long Path to Mandating Electric Reliability Standards through the Energy Policy Act of 2005

    Energy Technology Data Exchange (ETDEWEB)

    Young, Ellen Swyler

    2006-07-15

    The Act was the culmination of more than eight years of legislative effort in Congress. During this period, the nation saw the Western electricity crisis of 2000-01, the Sept. 11 attacks, the collapse of Enron, the growth of RTOs, and the August 2003 blackout. Each of these influenced the dynamics of the debate. (author)

  5. Range and limits of application of Sec.12, Atomic Energy Act, as a legal basis of the nuclear plant safety ordinance

    International Nuclear Information System (INIS)

    Schmidt-Preuss, Matthias

    2009-01-01

    Ensuring plant safety is a key purpose of nuclear law. Sec.7 II No.3, Atomic Energy Act, is considered the basic norm of nuclear legislation. The main requirement this embodies is ensuring 'the provisions against damage arising from construction and operation of a plant as required in accordance with the state of the art'. These normative requirements constitute the strictest yardstick existing in legislation about technology. Putting it into effect has always been the purpose of the set of nuclear rules and regulations constituting the next lower level of legislation, which so far have developed by evolution and are now to be updated comprehensively in the format of so-called modules as provided for in the concept of the Federal Ministry for the Environment, Nature Conservation, and Nuclear Safety (BMU). So far, there has not been a nuclear plant safety ordinance. The Atomic Energy Act has always provided a basis for adopting such an ordinance, especially so in Sec.12 I 1 No.1, Atomic Energy Act. No federal government has so far wanted to make use of it. This makes it all the more remarkable that the BMU took up the subject of a nuclear plant safety ordinance as early as in 2006, starting a dialog with the federal states. This dialog meanwhile has come to a halt. The subject seems to be dormant right now, but certainly has not been shelved. Ensuring plant safety is a key purpose of nuclear law. Sec.7 II No.3, Atomic Energy Act, is considered the basic norm of nuclear legislation. The main requirement this embodies is ensuring 'the provisions against damage arising from construction and operation of a plant as required in accordance with the state of the art'. These normative requirements constitute the strictest yardstick existing in legislation about technology. Putting it into effect has always been the purpose of the set of nuclear rules and regulations constituting the next lower level of legislation, which so far have developed by evolution and are now to be

  6. Steel and Aluminum Energy Conservation and Technology Competitiveness Act of 1988: Annual report of the metals initiative for fiscal year 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-01-01

    This annual report has been prepared for the President and Congress describing the activities carried out under the Steel and Aluminum Energy Conservation and Technology Competitiveness Act of 1988, commonly referred to as the Metals Initiative. The Act has the following purposes: (1) increase energy efficiency and enhance the competitiveness of the American steel, aluminum, and copper industries; and (2) continue research and development efforts begun under the U.S. Department of Energy (DOE) program known as the Steel Initiative. These activities are detailed in a subsequent section. Other sections describe the appropriation history, the distribution of funds through fiscal year 1996, and the estimated funds necessary to continue projects through fiscal year 1997. The Metals Initiative supported four research and development projects with the U.S. Steel industry: (1) steel plant waste oxide recycling and resource recovery by smelting, (2) electrochemical dezincing of steel scrap, (3) rapid analysis of molten metals using laser-produced plasmas, and (4) advanced process control. There are three Metals Initiative projects with the aluminum industry: (1) evaluation of TiB2-G cathode components, (2) energy efficient pressure calciner, and (3) spray forming of aluminum. 1 tab.

  7. Steel and Aluminum Energy Conservation and Technology Competitiveness Act of 1988: Annual report of the metals initiative for fiscal year 1996

    International Nuclear Information System (INIS)

    1998-01-01

    This annual report has been prepared for the President and Congress describing the activities carried out under the Steel and Aluminum Energy Conservation and Technology Competitiveness Act of 1988, commonly referred to as the Metals Initiative. The Act has the following purposes: (1) increase energy efficiency and enhance the competitiveness of the American steel, aluminum, and copper industries; and (2) continue research and development efforts begun under the U.S. Department of Energy (DOE) program known as the Steel Initiative. These activities are detailed in a subsequent section. Other sections describe the appropriation history, the distribution of funds through fiscal year 1996, and the estimated funds necessary to continue projects through fiscal year 1997. The Metals Initiative supported four research and development projects with the U.S. Steel industry: (1) steel plant waste oxide recycling and resource recovery by smelting, (2) electrochemical dezincing of steel scrap, (3) rapid analysis of molten metals using laser-produced plasmas, and (4) advanced process control. There are three Metals Initiative projects with the aluminum industry: (1) evaluation of TiB2-G cathode components, (2) energy efficient pressure calciner, and (3) spray forming of aluminum. 1 tab

  8. 75 FR 68094 - Partial Grant and Partial Denial of Clean Air Act Waiver Application Submitted by Growth Energy...

    Science.gov (United States)

    2010-11-04

    ... of the common metals, elastomers, and plastics used in motor vehicle fuel systems. Growth Energy... temperatures, component interaction, chemical changes, increased permeation, and materials degradation) that...

  9. Act of 18 July 1966 on Third Party Liability in the Field of Nuclear Energy, establishing certain measures regarding implementation of the Paris Convention and its additional protocol

    International Nuclear Information System (INIS)

    1966-01-01

    This Act on nuclear third party liability lays down that certain Articles (definitions, liability, scope and amounts of liability, insurance) of the Convention on Third Party Liability in the Field of Nuclear Energy (Paris Convention) are immediately applicable in Belgium. It stipulates that a nuclear operator is recognised as such by the King when he furnishes proof that he has taken out insurance or other financial security to cover his liability under this Act, without prejudice to implementation of legal and regulatory provisions on protection of the population against the hazards of ionizing radiations. Finally, the operator of a nuclear installation must take out and maintain, for each installation, insurance approved by the appropriate authorities; if the State itself operates a nuclear installation, it has no obligation to take out insurance or other financial security. (NEA) [fr

  10. Constitutional questions on a reform of the Atomic Energy Act, in particular on the distribution of administrative competence within the Federation

    International Nuclear Information System (INIS)

    Steinberg, R.

    1991-01-01

    The lecture deals in particular with the constitutional framing and the principles of the Laender administration on behalf of the Federal Government, the responsibility of the Land for subject matters and action and submit reports, court proceedings the barrier of Paragraph 85 II of the Basic Law: 'Directives'. The final conclusion is that the proposals to shift the administrative responsibilities for the execution of the Atomic Energy Act to the Federation and those for a supposed elimination of weak points in the Laender administration on behalf of the Federal Government are highly questionable in the face of constitutional law. The attempt at a new interpretation of the regulations on the Federal Government is equal to the intention of amending the Constitution without a law for such an amendment. What poses the foremost problems, however, is the perspective that is to set the course here for the reform of the Atomic Energy Act: strengthening of the Federation and further weakening of the competences of the Laender that constitute their autonomous statehood. No consideration is given to the point that structural changes to the atomic energy administration must necessarily effect other areas of the Laender administration on behalf of the Federal Government where the work done over more than 40 years has been to everyone's satisfaction. Then again the intention of fostering the nuclear industry by strengthening the Federal Government might backfire after the next elections to the Bundestag. (orig./HSCH) [de

  11. Article 74 sect. 1 no. 24 (air pollution control) as a competent fundament for Renewable Energy Resources Act and thermal energy law; Art. 74 Abs. Nr. 24 GG (Luftreinhaltung) als Kompetenzgrundlage fuer EEG und EEWaermeG

    Energy Technology Data Exchange (ETDEWEB)

    Soesemann, F. [Kammergericht, Berlin (Germany); Humboldt-Univ. Berlin (Germany); Ecologic gGmbH, Berlin (Germany)

    2008-08-15

    Since the reform of federalism, no examination of requirement is necessary in accordance with article 72 sect. 2 Basic Law in order to support federal laws on article 74 sect. 1 no. 24 Basic Law. It is in the interest of the federal law giver to legislate the climate protection such as Renewable Energy Resources Act and thermal energy law alone on the basis of the authority standard in order to avoid the examination of requirement. In the sense of the article 74 sect. 1 no. 24 Basic Law, the climate protection is considered as air pollution control and serves to the reduction of greenhouse gases.

  12. National Energy Policy Plan; A Report to Congress Required by Title VIII of the Department of Energy Organization Act (Public Law 95-91)

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    This plan report is divided into the following chapters: the course ahead, currently predominant fuels (oil, gas), America's energy triad, sources of diversity and long-term supply, sources of uncertainty, summary of current projections, and public comments on the nation's policy toward energy. (DLC)

  13. American Recovery and Reinvestment Act (ARRA) Federal Energy Management Program Technical Assistance Project 279 IMCOM-Southeast Region: Redstone Arsenal

    Energy Technology Data Exchange (ETDEWEB)

    Hatley, Darrel D.; Goddard, James K.

    2010-09-30

    Report describing a building retuning workshop presented to staff at Redstone Arsenal. Document includes issues identified during building audits and recommendations for future activities to reduce energy use at the site.

  14. Privacy Act

    Science.gov (United States)

    Learn about the Privacy Act of 1974, the Electronic Government Act of 2002, the Federal Information Security Management Act, and other information about the Environmental Protection Agency maintains its records.

  15. American Recovery and Reinvestment Act (ARRA) Federal Energy Management Program Technical Assistance Project 281 Solar Hot Water Application Assessment for U.S. Army IMCOM-Southeast Region

    Energy Technology Data Exchange (ETDEWEB)

    Russo, Bryan J.; Chvala, William D.

    2010-09-30

    The Energy Independence and Security Act of 2007 requires installations (EISA) to install solar systems of sufficient capacity to provide 30% of service hot water in new construction and renovations where cost-effective. However, installations are struggling with how to implement solar hot water, and while several installations are installing solar hot water on a limited basis, paybacks remain long. Pacific Northwest National Laboratory (PNNL) was tasked to address this issue to help determine how best to implement solar hot water projects. This documents discusses the results of that project.

  16. Code of Conduct for Gas Marketers : rule made under part 3 of the Ontario Energy Board Act, 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-02

    Text of the code of conduct for gas marketers in Ontario is presented. This code sets the minimum standards under which a gas marketer may sell or offer to sell gas to a low-volume consumer, or act as an agent or broker with respect to the sale of gas. The document describes the standards and principles regarding: (1) fair marketing practices, (2) identification, (3) information to be maintained by a gas marketer, (4) confidentiality of consumer information, (5) conditions in offers, (6) contracts, (7) contract renewals, (8) assignment, sale and transfer contracts, (9) independent arms-length consumer complaints resolution process, and (10) penalties for breach of this code.

  17. Code of Conduct for Gas Marketers : rule made under part 3 of the Ontario Energy Board Act, 1998

    International Nuclear Information System (INIS)

    1999-01-01

    Text of the code of conduct for gas marketers in Ontario is presented. This code sets the minimum standards under which a gas marketer may sell or offer to sell gas to a low-volume consumer, or act as an agent or broker with respect to the sale of gas. The document describes the standards and principles regarding: (1) fair marketing practices, (2) identification, (3) information to be maintained by a gas marketer, (4) confidentiality of consumer information, (5) conditions in offers, (6) contracts, (7) contract renewals, (8) assignment, sale and transfer contracts, (9) independent arms-length consumer complaints resolution process, and (10) penalties for breach of this code

  18. p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.

    Science.gov (United States)

    Morselli, Eugenia; Shen, Shensi; Ruckenstuhl, Christoph; Bauer, Maria Anna; Mariño, Guillermo; Galluzzi, Lorenzo; Criollo, Alfredo; Michaud, Mickael; Maiuri, Maria Chiara; Chano, Tokuhiro; Madeo, Frank; Kroemer, Guido

    2011-08-15

    The tumor suppressor protein p53 tonically suppresses autophagy when it is present in the cytoplasm. This effect is phylogenetically conserved from mammals to nematodes, and human p53 can inhibit autophagy in yeast, as we show here. Bioinformatic investigations of the p53 interactome in relationship to the autophagy-relevant protein network underscored the possible relevance of a direct molecular interaction between p53 and the mammalian ortholog of the essential yeast autophagy protein Atg17, namely RB1-inducible coiled-coil protein 1 (RB1CC1), also called FAK family kinase-interacting protein of 200 KDa (FIP200). Mutational analyses revealed that a single point mutation in p53 (K382R) abolished its capacity to inhibit autophagy upon transfection into p53-deficient human colon cancer or yeast cells. In conditions in which wild-type p53 co-immunoprecipitated with RB1CC1/FIP200, p53 (K382R) failed to do so, underscoring the importance of the physical interaction between these proteins for the control of autophagy. In conclusion, p53 regulates autophagy through a direct molecular interaction with RB1CC1/FIP200, a protein that is essential for the very apical step of autophagy initiation.

  19. Silencing of RpATG6 impaired the yolk accumulation and the biogenesis of the yolk organelles in the insect vector R. prolixus.

    Directory of Open Access Journals (Sweden)

    Priscila H Vieira

    2018-05-01

    Full Text Available In oviparous animals, the egg yolk is synthesized by the mother in a major metabolic challenge, where the different yolk components are secreted to the hemolymph and delivered to the oocytes mostly by endocytosis. The yolk macromolecules are then stored in a wide range of endocytic-originated vesicles which are collectively referred to as yolk organelles and occupy most of the mature oocytes cytoplasm. After fertilization, the contents of these organelles are degraded in a regulated manner to supply the embryo cells with fundamental molecules for de novo synthesis. Yolk accumulation and its regulated degradation are therefore crucial for successful development, however, most of the molecular mechanisms involved in the biogenesis, sorting and degradation of targeted yolk organelles are still poorly understood. ATG6 is part of two PI3P-kinase complexes that can regulate the recruitment of the endocytic or the autophagy machineries. Here, we investigate the role of RpATG6 in the endocytosis of the yolk macromolecules and in the biogenesis of the yolk organelles in the insect vector Rhodnius prolixus. We found that vitellogenic females express high levels of RpATG6 in the ovaries, when compared to the levels detected in the midgut and fat body. RNAi silencing of RpATG6 resulted in yolk proteins accumulated in the vitellogenic hemolymph, as a consequence of poor uptake by the oocytes. Accordingly, the silenced oocytes are unviable, white (contrasting to the control pink oocytes, smaller (62% of the control oocyte volume and accumulate only 40% of the yolk proteins, 80% of the TAG and 50% of the polymer polyphosphate quantified in control oocytes. The cortex of silenced oocytes present atypical smaller vesicles indicating that the yolk organelles were not properly formed and/or sorted, which was supported by the lack of endocytic vesicles near the plasma membrane of silenced oocytes as seen by TEM. Altogether, we found that RpATG6 is central for the

  20. Survey of the authorities competent for licensing and supervision in the field of radiation protection under the terms of the Atomic Energy Act (As of January 1980)

    International Nuclear Information System (INIS)

    1980-01-01

    Contents: 1. Portfolio of the Federal Minister of Defence. 2. Handling of other radioactive substances, equipment for the generation of ionizing radiation and activities in installations owned by third parties: 2.1 Licensing authorities; 2.2 competent authorities for the acception and documentation of notifications required under sections 4, sub-section 1, 17 sub-section 1, of the Radiation Protection Ordinance; 2.3 authorities competent for the registration of radiation records; 2.4 supervisory authorities. 3. Carriage of radioactive substances: 3.1 Federal authorities responsible for licensing and supervisions; 3.2 Land authorities responsible for licensing; 3.3 Land authorities responsible for supervision. 4. Permits concerning the design of equipment. 5. Import and export of radioactive substances: 5.1 Licensing authorities; 5.2 supervisory authorities. 6. Competent authorities in accordance with section 63 sub-section 3 paragraph 1 of the Radiation Protection Ordinance (monitoring stations) and according to the provisions of Land legislation. 7. Licensing and supervisory authorities for the treatment, processing or any other use of nuclear fuels under section 9 of the Atomic Energy Act. 8. Competences of the Laender in the implementation of the Atomic Energy Act and the Radiation Protection Ordinance. (orig.) [de

  1. The terms 'current scientific knowledge', and 'precautionary measures to provide protection' in the provisions governing the licensing procedure under the Atomic Energy Act

    International Nuclear Information System (INIS)

    Renneberg, W.

    1986-01-01

    Under the Atomic Energy Act, a licence may be granted for a nuclear installation provided that 'every precaution which is necessary in the light of existing scientific knowledge and technology has been taken to provide adequate protection against damage due to the erection or operation of the installation' (section 7, sub-sec. (2), no. 3 of the Atomic Energy Act). This condition can be split off into two specific problem fields, and for each a rather unspecific legal concept is to be more exactly defined. The author explains the technique of the law hitherto applied in the weighting and evaluation of hazards and risks and comes to the conclusion that the technique adopted has been subject to pre-legal appraisals: the result in terms of the law is not the final step in the process of legal evaluation, but quite to the contrary, the legal technique applied has been derived from the wanted result. This, the author says, is a crisis of legitimation of the law. (HSCH) [de

  2. Energy-water nexus of wind power in China: The balancing act between CO2 emissions and water consumption

    International Nuclear Information System (INIS)

    Li Xin; Feng Kuishuang; Siu, Yim Ling; Hubacek, Klaus

    2012-01-01

    At the end of 2010, China's contribution to global CO 2 emissions reached 25.1%. Estimates show that power generation accounts for 37.2% of the Chinese CO 2 emissions. Even though there is an increasing number of studies using life cycle analysis (LCA) to examine energy consumption and CO 2 emissions required by different types of power generation technologies, there are very few studies focusing on China. Furthermore, the nexus between water consumption and energy production has largely been ignored. In this paper, we adopt input–output based hybrid life cycle analysis to evaluate water consumption and CO 2 emissions of wind power in China. Our results show that China's wind energy consumes 0.64 l/kWh of water and produces 69.9 g/kWh of CO 2 emission. Given that the Chinese government aims to increase the wind power generation capacity to 200 GW by 2020, wind power could contribute a 23% reduction in carbon intensity and could save 800 million m 3 of water which could be sufficient enough for use by 11.2 million households. Thus, given the often postulated water crisis, China's energy policy would reap double benefits through progressive energy policies when increasing the share of wind power as part of overall efforts to diversify its electricity generation technologies. - Highlights: ► The nexus of water consumption and CO 2 emission of China's wind power is examined. ► Wind power consumes 0.64 l/kWh of water and produces 69.9 g/kWh of CO 2 . ► Wind power could save 800 million m 3 of water for use by 11.2 million households. ► Wind power could contribute 23% of China's carbon intensity target by 2020. ► Wind power deemed to be a viable means of achieving carbon and water savings.

  3. Delegation of Authority to Review Leases of Property at Department of Energy Weapon Production Facilities Under the Department of Energy Organization Act

    Science.gov (United States)

    The purpose of this memorandum is to request that the Human Resources Staff for OSWER and OECA start the Green Border review process for the attached draft delegation of authority, which delegates the authority of the Administrator to review leases of property at Department of Energy (DOE) weapon production facilities to the Assistant Administrator for OSWER and Regional Administrators.

  4. The association between dietary energy density and type 2 diabetes in Europe: results from the EPIC-InterAct Study.

    Directory of Open Access Journals (Sweden)

    Saskia W van den Berg

    Full Text Available Observational studies implicate higher dietary energy density (DED as a potential risk factor for weight gain and obesity. It has been hypothesized that DED may also be associated with risk of type 2 diabetes (T2D, but limited evidence exists. Therefore, we investigated the association between DED and risk of T2D in a large prospective study with heterogeneity of dietary intake.A case-cohort study was nested within the European Prospective Investigation into Cancer (EPIC study of 340,234 participants contributing 3.99 million person years of follow-up, identifying 12,403 incident diabetes cases and a random subcohort of 16,835 individuals from 8 European countries. DED was calculated as energy (kcal from foods (except beverages divided by the weight (gram of foods estimated from dietary questionnaires. Prentice-weighted Cox proportional hazard regression models were fitted by country. Risk estimates were pooled by random effects meta-analysis and heterogeneity was evaluated. Estimated mean (sd DED was 1.5 (0.3 kcal/g among cases and subcohort members, varying across countries (range 1.4-1.7 kcal/g. After adjustment for age, sex, smoking, physical activity, alcohol intake, energy intake from beverages and misreporting of dietary intake, no association was observed between DED and T2D (HR 1.02 (95% CI: 0.93-1.13, which was consistent across countries (I(2 = 2.9%.In this large European case-cohort study no association between DED of solid and semi-solid foods and risk of T2D was observed. However, despite the fact that there currently is no conclusive evidence for an association between DED and T2DM risk, choosing low energy dense foods should be promoted as they support current WHO recommendations to prevent chronic diseases.

  5. The social conflict about nuclear energy and the procedure of public participation - theses explaining the demand for operative acts

    International Nuclear Information System (INIS)

    Gloede, F.

    1989-01-01

    (1) The opinion of the population on the participation procedure depends on its judgement of the project. (2) Judgement of the leading groups taking part in the procedure is an independent factor. (3) The fundamental disagreement about the use of nuclear energy cannot be adjusted by administrative procedures. (4) The gradational disagreement about nuclear engineering projects suggests a procedural reform. (5) Political settlement of the fundamental controversy and reforms of the public participation procedure cannot be substituted one for the other. (6) There is a social and political interaction between the fundamental and the gradational disagreement. (orig.) [de

  6. Law for the expanion of renewable energies. German Renewable Energy Act 2014 - EEG 2014. Special volume to volume 2. 3. new rev. and enl. ed.

    International Nuclear Information System (INIS)

    Saecker, Franz Juergen

    2015-01-01

    No field of law is currently so intense in motion as the energy law. The amendment of 2014 has been for one of the most important tools for implementing the energy transition in Germany, the EEG, a ''fundamental reform'' (as in the title of the Law of 07.21.2014). In the present additional special volume of Berlin commentary on energy law EEG 2014 is explained with all its serious changes by respected academics and practitioners; the possibility of the draft amendment to the federal government is already taken into account by 01.04.2015. Particular attention will be the new rules for tendering promoting of greenfield installations. Questions of auditing which have the great practical importance under the amended regulations for placement exemption under paragraph paragraph 60 ff. EEG 2014, for the first time commented on by auditors. Besides dogmatic foundations of comment therefore provides an important aid in practical issues of relevance levy burden and its exceptions. [de

  7. Proceedings of the International Conference on Wind Energy in Remote Regions; Actes du Colloque International sur Energie Eolienne et Site Eloignes

    Energy Technology Data Exchange (ETDEWEB)

    Gipe, P.; Brudny, J.F.; Ilinca, A.; Bouchard, Y.; Proulx, P.; Chaumel, J.L.; Brunelle, M.T.; Henin, S.; Beaudoin, P.; Poirier, N.; Belanger, M. [Quebec Univ., Rimouski, PQ (Canada). WERR Organizational Committee

    2005-07-01

    This international conference focused on the growth opportunities for the wind power industry in Canada, with particular focus on Quebec and eastern Canada. The conference presented formal paper sessions dealing with the largest wind turbine technology to the smallest machines. It also included tutorials, site visits, case studies and commercial exhibits aimed at wind power developers, utility managers, manufacturers, sub-contractors, theoreticians and practitioners. Participants discussed the best and innovative solutions for the efficient regional development of wind power with particular focus on remote, off-grid applications such as isolated northern communities and islands. The presentations emphasized how wind energy can allow isolated communities to reduce their dependence on costly imported diesel fuel by combining modern electronics with wind turbines and diesel power systems. Environmental impacts and future innovations in wind technology were also discussed along with practical solutions for combining wind energy with other sources of energy. The conference featured 30 presentations, of which 18 have been catalogued separately for inclusion in this database. refs., tabs., figs.

  8. Nuclear Non-Proliferation Policy Act of 1977. Hearings before the Subcommittee on Energy Research and Development of the Committee on Energy and Natural Resources, United States Senate, Ninety-Fifth Congress, First Session on S. 897 and S. 1432

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    On April 7, 1977, President Carter announced his nuclear power policy. The policy statement set forth seven specific objectives for the future use of nuclear energy in this country and the rest of the world. The two proposed instruments for implementing this policy are the revised fiscal year 1978 ERDA authorization draft bill and S. 1432, the Nuclear Non-Proliferation Act of 1977. These legislative proposals are linked in that S. 1432 is designed to establish a non-proliferation framework with specific objectives established for the ERDA nuclear energy programs. The ERDA authorization bill is the budgetary vehicle to implement those objectives. The Committee on Energy and Natural Resources obtained joint referral of certain portions of the Nuclear Non-Proliferation Act to insure that non-proliferation policy is implemented in a manner consistent with the policy of having sufficient energy for this country and foreign countries in the future. The Subcommittee on Energy Research and Development must examine the costs and the consequences of various initiatives before they are implemented. F or example, the proposal to guarantee uranium enrichment services for foreign nations poses specific requirements on ERDA to expand considerably our enrichment capacity by the year 2000. Without reprocessing, it is expected that spent fuel rods from abroad will be returned to this country for storage with attendant costs and siting decisions. Also, international fuel-cycle evaluation programs must be carefully examined to insure that all options, including regional fuel cycle centers with international controls and inspection, are considered in seeking international approaches to the non-proliferation objectives. At the June 10 hearing, the subcommittee received testimony on S. 1432, the bill prepared by the administration. The hearings on September 13 and 14 focused on S. 897. Statements by many witnesses are included

  9. Possibilities of sanction of the improper behaviour of a power network operator. Instruments of energy economy act, public order law, and criminal law; Sanktionsmoeglichkeiten bei missbraeuchlichem Verhalten eines Energienetzbetreibers. Energiewirtschaftsrechtliche, ordnungsrechtliche und strafrechtliche Instrumentarien

    Energy Technology Data Exchange (ETDEWEB)

    Mitto, L.

    2007-07-01

    The liberalization of the electric power market and gas market has released a comprehensive reorganisation of the energy branch. Under this aspect, the author of the book under consideration reports on power network operators, their improper behaviour as well as the use of the instruments of energy economy act, public order law, and criminal law in order to sanction power network operators.

  10. Climate policy and energy-intensive manufacturing: A comprehensive analysis of the effectiveness of cost mitigation provisions in the American Energy and Security Act of 2009

    International Nuclear Information System (INIS)

    Bassi, Andrea M.; Yudken, Joel S.

    2011-01-01

    In response to the ongoing climate policy debates, this study examines the cost impacts of carbon-pricing legislation on selected US energy-intensive manufacturing industries. Specifically, it evaluates output-based rebate measures and the border adjustment provision specified in the bill, and tests the effectiveness of cost containment features of the policy, such as the international offsets, under various market assumptions. Results of the examination confirm that in all policy cases or industries, the output-based rebates would effectively mitigate the manufacturers' carbon-pricing costs in the short-to-medium term. However as the rebates decline after 2020, especially in a case where low-carbon electricity generation or international offsets are not readily available or implemented, these industries would suffer greater declines in profitability. At the same time, the study's findings were mixed concerning the effectiveness of the border adjustment measure in reducing cost impacts after 2020. While border adjustments could reduce costs to US manufacturing sectors, at least temporarily, they could create problems for domestic downstream producers and exports, under cost pass-along conditions. However at best, the output-based rebates, international offset, and border adjustment and measures primarily buy time for manufacturers. The only long-term solution is for EITE industries to invest in energy-saving and next-generation low-carbon technologies. - Highlights: → The output-based rebates would effectively mitigate the costs of carbon-pricing for EITE industries. → After 2021 economic impacts on the EITE industries would escalate. → The BA measure would support US firms passing through their emissions costs to their US customers. → The BA measure would not alleviate the higher production costs of US. EITE exports. → In the medium term the only true solution is for US. EITE manufacturers to invest in energy-saving technologies.

  11. Autophagy Deficiency Compromises Alternative Pathways of Respiration following Energy Deprivation in Arabidopsis thaliana.

    Science.gov (United States)

    Barros, Jessica A S; Cavalcanti, João Henrique F; Medeiros, David B; Nunes-Nesi, Adriano; Avin-Wittenberg, Tamar; Fernie, Alisdair R; Araújo, Wagner L

    2017-09-01

    Under heterotrophic conditions, carbohydrate oxidation inside the mitochondrion is the primary energy source for cellular metabolism. However, during energy-limited conditions, alternative substrates are required to support respiration. Amino acid oxidation in plant cells plays a key role in this by generating electrons that can be transferred to the mitochondrial electron transport chain via the electron transfer flavoprotein/ubiquinone oxidoreductase system. Autophagy, a catabolic mechanism for macromolecule and protein recycling, allows the maintenance of amino acid pools and nutrient remobilization. Although the association between autophagy and alternative respiratory substrates has been suggested, the extent to which autophagy and primary metabolism interact to support plant respiration remains unclear. To investigate the metabolic importance of autophagy during development and under extended darkness, Arabidopsis ( Arabidopsis thaliana ) mutants with disruption of autophagy ( atg mutants) were used. Under normal growth conditions, atg mutants showed lower growth and seed production with no impact on photosynthesis. Following extended darkness, atg mutants were characterized by signatures of early senescence, including decreased chlorophyll content and maximum photochemical efficiency of photosystem II coupled with increases in dark respiration. Transcript levels of genes involved in alternative pathways of respiration and amino acid catabolism were up-regulated in atg mutants. The metabolite profiles of dark-treated leaves revealed an extensive metabolic reprogramming in which increases in amino acid levels were partially compromised in atg mutants. Although an enhanced respiration in atg mutants was observed during extended darkness, autophagy deficiency compromises protein degradation and the generation of amino acids used as alternative substrates to the respiration. © 2017 American Society of Plant Biologists. All Rights Reserved.

  12. Nuclear Siting and Licensing Act of 1978. Hearings before the Subcommittee on Energy and Power, Committee on Interstate and Foreign Commerce, House of Representatives, Ninety-Fifth Congress

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    The Subcommittee on Energy and Power conducted hearings on the administration proposal to revise the process by which nuclear power plants are licensed. The purpose of this proposal is to substantially reduce the amount of time needed to license and construct nuclear powerplants. The bill attempts to encourage the early selection of possible sites by separating the process by which such sites are approved fom the process by which plants are licensed. The bill would dispense with the existing requirement that all hearings be adjudicatory, and instead authorize informal hearings on certain issues, principally those which would be conducted pursuant to the National Environmental Policy Act of 1969. The bill would authorize a State which has established a program, consistent with the criteria contained in the act and regulations promulgated by the Nuclear Regulatory Commission, to determine the environmental acceptability of, and/or the need for, a proposed nuclear plant which would be located within its boundaries. Finally, the bill seeks to encourage the use of standardized design and authorizes the NRC to provide funds to intervenors under certain specified conditions

  13. The function and the structural characteristics of the state-of-the-art concept in the provisions for damage required under the Atomic Energy Act

    International Nuclear Information System (INIS)

    Obenhaus, W.; Kuckuck, B.

    1980-01-01

    The authors examine the function and the structural characteristcs of the state-of-the-art concept. It is described as a yardstick in judging the means to be employed to attain the goals of protection under Sec. 1, Subsec. 2 of the Atomic Energy Act. The concept was used to ensure that the advances in theoretical knowledge were met also by an adequate development of technical measures of protection so as to ensure a maximum of safety. The concept included a scientific and engineering state of the art, which allowed a sufficiently reliable forecast to be made of the technical feasibility of science-based concepts of safety and protection. The forecast constituted an obligation to monitor the progress of the state of the art by elucidating progressive developments in safety proposals and concerns. (HSCH) [de

  14. Slovak Republic Act of 1 April 1998 on the peaceful use of nuclear energy and on alterations and amendments to Act No. 174/1968 Zb. on State supervision of work safety as amended by Act of the National Council of the Slovak Republic No. 256/1994 Z.z

    International Nuclear Information System (INIS)

    1998-01-01

    This Act is a part of Report and contains: Part I. Chapter (Ch.) one: Basic provisions; Paragraph (P) 1: Subject of act; P2: Definition of certain terms; P3: Principles of peaceful use of nuclear energy; P4: Conditions for use of nuclear energy; P5: Conditions for issue of authorization; P6: Application for the issue of an authorization; P7: Issue of authorization; P8: Termination and limitation of authorization; P8: Termination and limitation of authorization. Ch.2: Nuclear materials; P9: Nuclear materials, special materials and equipment; P10: Procurement and use of nuclear materials (NM); P11: Transportation of NM; P12: Accounting and control of NM; Ch.3: Nuclear installations, management of radioactive waste and spent nuclear fuel; P13: Nuclear installation (NI); P14: Construction of nuclear installations (NI); P15. Commissioning and operation of NI; P16. Extension of operational lifetime of NI; P17: Radioactive waste management; P18: Management of spent nuclear fuel; P19: Decommissioning of NIs; Ch.4. Nuclear safety and quality assurance; P20: Nuclear safety; P21: Professional qualification; P22: Quality assurance; P23: Physical protection of NIs and NMs; P24. Events at nuclear installations and accidents during transportation of NMs; P25: Emergency planning; Ch.5. P26: Nuclear damage and compensation for such damage; P27: Liability for nuclear damage; P28: Limitation of liability; P29: Meeting of claims for compensation for nuclear damage; P30: Financial cover for nuclear damage liability. Ch.6: NRA SR. P31: Competence of the Authority; P32: The Authority performs the State supervision; P33: The obligations of the authorized persons towards the authority and apprising by the authority of the national organs; P34: Nuclear safety inspectors; P35: Discontinuation of the operating of a NI or its construction. P36: Penalties. Ch.7. Common, temporary and concluding provisions. P37. Relation to administrative procedure; P38: Temporary provisions; P39: Abrogation

  15. Slovak Republic act of 1 April 1998 on the peaceful use of nuclear energy and on alterations and amendments to Act No. 174/1968 Collection of laws of CSSR on State supervision of work safety as amended by Act of the National Council of the Slovak Republic No. 256/1994 of Collection of laws of the Slovak Republic

    International Nuclear Information System (INIS)

    1998-01-01

    These act contains: Part I. Chapter (Ch.) one: Basic provisions; Paragraph (P) 1: Subject of act; P2: Definition of certain terms; P3: Principles of peaceful use of nuclear energy; P4: Conditions for use of nuclear energy; P5: Conditions for issue of authorization; P6: Application for the issue of an authorization; P7: Issue of authorization; P8: Termination and limitation of authorization; P8: Termination and limitation of authorization. Ch.2: Nuclear materials; P9: Nuclear materials, special materials and equipment; P10: Procurement and use of nuclear materials (NM); P11: Transportation of NM; P12: Accounting and control of NM; Ch.3: Nuclear installations, management of radioactive waste and spent nuclear fuel; P13: Nuclear installation (NI); P14: Construction of nuclear installations (NI); P15. Commissioning and operation of NI; P16. Extension of operational lifetime of NI; P17: Radioactive waste management; P18: Management of spent nuclear fuel; P19: Decommissioning of NIs; Ch.4. Nuclear safety and quality assurance; P20: Nuclear safety; P21: Professional qualification; P22: Quality assurance; P23: Physical protection of NIs and NMs; P24. Events at nuclear installations and accidents during transportation of NMs; P25: Emergency planning; Ch.5. P26: Nuclear damage and compensation for such damage; P27: Liability for nuclear damage; P28: Limitation of liability; P29: Meeting of claims for compensation for nuclear damage; P30: Financial cover for nuclear damage liability. Ch.6: NRA SR. P31: Competence of the Authority; P32: The Authority performs the State supervision; P33: The obligations of the authorized persons towards the authority and apprising by the authority of the national organs; P34: Nuclear safety inspectors; P35: Discontinuation of the operating of a NI or its construction. P36: Penalties. Ch.7. Common, temporary and concluding provisions. P37. Relation to administrative procedure; P38: Temporary provisions; P39: Abrogation provision; P40: List of

  16. German legislation for promotion of renewable energies 2014. Act on feed-in and guaranteed pricing of electricity from renewable energy sources (EEG). Commentary. 7. new rev. ed.

    International Nuclear Information System (INIS)

    Salje, Peter

    2015-01-01

    The EEG is continuously subjected to changes and the permanent center of political discussions. Therefore now already the 7th edition of the EEG comment of the science and practice well recognized and highly recognized author Prof. Dr. Dr. Peter Salje appear. The revision includes, inter alia, further evaluation of the law of electric power produced from renewable energy sources from the EEG of 2012 and the regulations made there under (including Biomass and AusglMechV). The changes associated with the so-called Photovoltaic amendment dated August 2012 and the recent case law since the publication of the previous edition handed down are considered. In particular, the incorporation of the full basic EEG reform in 2014 guarantees the highest topicality. [de

  17. Nuclear Non-Proliferation Policy Act of 1977. Hearings before the Subcommittee on Energy Research and Development of the Committee on Energy and Natural Resources, United States Senate, Ninety-Fifth Congress, First Session, June 10, September 13, 14, 1977

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    Senator Frank Church presented the opening statement on the June 10, 1977 hearing concerning the Nuclear Non-Proliferation Policy Act of 1977, S.1432. S.1432 is designed to establish a nonproliferation framework with specific objectives established for the ERDA nuclear energy programs. The ERDA authorization bill is the budgetary vehicle to implement these objectives. The Committee on Energy and Natural Resources obtained joint referral of certain portions of the Nuclear Non-Proliferation Act to insure that nonproliferation policy is implemented in a manner consistent with the policy of having sufficent energy for this country and foreign countries in the future. Additionally, the Subcommittee on Energy Research and Development must examine the cost and the consequences of various initiatives before they are implemented. For example, the proposal to guarantee uranium enrichment services for foreign nations poses specific requirements on ERDA to expand considerably our enrichment capacity by the year 2000. Without reprocessing, it is expected that spent fuel rods from abroad will be returned to this country for storage with attendant costs and siting decisions. Also, international fuel cycle evaluation programs must be carefully examined to insure that all options, including regional fuel cycle centers with international controls and inspection, are considered in seeking international approaches to the nonproliferation objectives. It is these and related questions to which the subcommittee seeks answers. The hearings on September 13 and 14 focused on S.897, a bill to strengthen U.S. policies on nonproliferation and to reorganize certain export functions of the Federal government to promote more efficient administration of such functions. Statements were presented by experts in government, private firms, and industrial sectors

  18. ACTS 2014

    DEFF Research Database (Denmark)

    Co-curator of ACTS 2014 together with Rasmus Holmboe, Judith Schwarzbart and Sanne Kofoed. ACTS is the Museum of Contemporary Art’s international bi-annual festival. ACTS was established in 2011 and, while the primary focus is on sound and performance art, it also looks toward socially oriented art....... For the 2014 festival, the museum has entered into a collaboration with the Department for Performance Design at Roskilde University – with continued focus on sound and performance art, and social art in public spaces. With ACTS, art moves out of its usual exhibition space and instead utilizes the city, its...... various possibilities and public spaces as a stage. ACTS takes place in and around the museum and diverse locations in Roskilde city. ACTS is partly curated by the museum staff and partly by guest curators. ACTS 2014 is supported by Nordea-fonden and is a part of the project The Museum goes downtown....

  19. The Clean Air Act

    International Nuclear Information System (INIS)

    Coburn, L.L.

    1990-01-01

    The Clean Air Act amendments alter the complex laws affecting atmospheric pollution and at the same time have broad implications for energy. Specifically, the Clean Air Act amendments for the first time deal with the environmental problem of acid deposition in a way that minimizes energy and economic impacts. By relying upon a market-based system of emission trading, a least cost solution will be used to reduce sulfur dioxide (SO 2 ) emissions by almost 40 percent. The emission trading system is the centerpiece of the Clean Air Act (CAA) amendments effort to resolve energy and environmental interactions in a manner that will maximize environmental solutions while minimizing energy impacts. This paper will explore how the present CAA amendments deal with the emission trading system and the likely impact of the emission trading system and the CAA amendments upon the electric power industry

  20. Establishment of networks in the energy economy. Change management in the background of the revised version of the energy economy act; Etablierung von Netzwerken in der Energiewirtschaft. Change Management vor dem Hintergrund der Neufassung des Energiewirtschaftsgesetzes

    Energy Technology Data Exchange (ETDEWEB)

    Meister, F.

    2007-02-15

    The revision of the energy economy act results into fundamental modifications with respect to the energy economy. Especially, smaller public utilities are threatened in their existence due to the liberalisation of the European current markets. In order to exist in the competition, company networks offer themselves as a solution. The establishment of such networks failed due to an extreme complexity, political interests, insufficient trust in co-operation partners as well as company cultural problems. Under this aspect, the author of the book under consideration reports on an analysis of six successful networks and one unsuccessful network. It is shown how networks generally and especially in the energy economy can be realized successfully. Apart from economical questions sociological and psychological aspects are examined. Main aspects are distribution of power, building up of confidence, regionality and transferring network contents. The author develops a comprehensive approach of change management in order to establish company networks and identifies success factors as well as failure factors with respect to the practical conversion. This book is written for lecturers and students of the applied economics (main field: research of networks, change management, personnel, organization, management and energy economy), managers in the area of company development of power supply companies as well as management consultants and personnel companies.

  1. Impact on the steam electric power industry of deleting Section 316(a) of the Clean Water Act: Energy and environmental impacts

    International Nuclear Information System (INIS)

    Veil, J.A.; VanKuiken, J.C.; Folga, S.; Gillette, J.L.

    1993-01-01

    Many power plants discharge large volumes of cooling water. In some cases, the temperature of the discharge exceeds state thermal requirements. Section 316(a) of the Clean Water Act (CWA) allows a thermal discharger to demonstrate that less stringent thermal effluent limitations would still protect aquatic life. About 32% of the total steam electric generating capacity in the United States operates under Section 316(a) variances. In 1991, the US Senate proposed legislation that would delete Section 316(a) from the CWA. This study, presented in two companion reports, examines how this legislation would affect the steam electric power industry. This report quantitatively and qualitatively evaluates the energy and environmental impacts of deleting the variance. No evidence exists that Section 316(a) variances have caused any widespread environmental problems. Conversion from once-through cooling to cooling towers would result in a loss of plant output of 14.7-23.7 billion kilowatt-hours. The cost to make up the lost energy is estimated at $12.8-$23.7 billion (in 1992 dollars). Conversion to cooling towers would increase emission of pollutants to the atmosphere and water loss through evaporation. The second report describes alternatives available to plants that currently operate under the variance and estimates the national cost of implementing such alternatives. Little justification has been found for removing the 316(a) variance from the CWA

  2. A quantum theory of the self-energy of non-relativistic fermions and of the Coulomb-Yukawa force acting between them

    International Nuclear Information System (INIS)

    Ernst, V.

    1978-01-01

    The idea of the systematic Weisskopf-Wigner approximation as used sporadically in atomic physics and quantum optics, is extended here to the interaction of a field of non-relativistic fermions with a field of relativistic bosons. It is shown that the usual (non-existing) interaction Hamiltonian of this system can be written as a sum of a countable number of self-adjoint and bounded partial Hamiltonians. The system of these Hamiltonians defines the order hierarchy of the present approximation scheme. To demonstrate its physical utility it is shown that in a certain order it provides satisfactory quantum theory of the 'self-energy' of the fermions under discussion. This is defined as the binding energy of bosons bound to the fermions and building up the latter's 'individual Coulomb or Yukawa fields' in the sense of expectation values of the corresponding field operator. In states of more than one fermion the bound photons act as a mediating agent between the fermions; this mechanism closely resembles the Coulomb or Yukawa 'forces' used in conventional non-relativistic quantum mechanics. (author)

  3. Quantifying the Impact of Vehicle and Motor Fuel Provisions from the Energy Policy Act on the Sustainability and Resilience of U.S. Cities: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Steward, Darlene; Sears, Ted

    2017-02-01

    The Energy Policy Act (EPAct) of 1992, with later amendments, was enacted with the goal of reducing U.S. petroleum consumption by building a core market for alternative fuels and vehicles. The U.S. Department of Energy manages three federal programs related to EPAct; the Sustainable Federal Fleets Program, the State and Alternative Fuel Provider Program, and Clean Cities. Federal agencies and State and Alternative Fuel Provider Fleets are required to submit annual reports that document their compliance with the legislation. Clean Cities is a voluntary program aimed at building partnerships and providing technical expertise to encourage cities to reduce petroleum use in transportation. This study reviews the evolution of these three programs in relation to alternative fuel and vehicle markets and private sector adoption of alternative fueled vehicles to assess the impact of the programs on reduction in petroleum use and greenhouse gas emissions both within the regulated fleets and through development of alternative fuel and vehicle markets. The increased availability of alternative fuels and use of alternative fuels in regulated fleets is expected to improve cities' ability to respond to and quickly recover from both local disasters and short- and long-term regional or national fuel supply interruptions. Our analysis examines the benefits as well as potential drawbacks of alternative fuel use for the resiliency of U.S. cities.

  4. Overexpression of the autophagy-related gene SiATG8a from foxtail millet (Setaria italica L.) confers tolerance to both nitrogen starvation and drought stress in Arabidopsis.

    Science.gov (United States)

    Li, Wei-wei; Chen, Ming; Zhong, Li; Liu, Jia-ming; Xu, Zhao-shi; Li, Lian-cheng; Zhou, Yong-Bin; Guo, Chang-Hong; Ma, You-Zhi

    2015-12-25

    Autophagy is an evolutionarily conserved biological process in all eukaryotes for the degradation of intracellular components for nutrient recycling. Autophagy is known to be involved in responses to low nitrogen stress in Arabidopsis. Foxtail millet has strong abiotic stress resistance to both low nutrient and drought stress. However, to date, there have only been a few genes reported to be related with abiotic stress resistance in foxtail millet. In this study, we identified an autophagy-related gene, SiATG8a, from foxtail millet. SiATG8a is mainly expressed in stems and its expression was dramatically induced by drought stress and nitrogen starvation treatments. SiATG8a was localized in the membrane and cytoplasm of foxtail millet. Overexpression of SiATG8a in Arabidopsis conferred tolerance to both nitrogen starvation and to drought stress. Under nitrogen starvation conditions, the SiATG8a transgenic plants had larger root and leaf areas and accumulated more total nitrogen than wild-type plants. The transgenic plants had lower total protein concentrations than did the WT plants. Under drought stress, the SiATG8a transgenic plants had higher survival rates, chlorophyll content, and proline content, but had lower MDA content than wild type plants. Taken together, our results represent the first identified case where overexpression of autophagy related gene can simultaneously improve plant resistance to low nitrogen and drought stresses. These findings implicate plant autophagy in plant stress responses to low nitrogen and drought and should be helpful in efforts to improve stresses resistance to nitrogen starvation and drought of crops by genetic transformation. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Autophagy adaptor protein p62/SQSTM1 and autophagy-related gene Atg5 mediate autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells.

    Directory of Open Access Journals (Sweden)

    Shintaro Seto

    Full Text Available Mycobacterium tuberculosis is an intracellular pathogen that can survive within phagocytic cells by inhibiting phagolysosome biogenesis. However, host cells can control the intracellular M. tuberculosis burden by the induction of autophagy. The mechanism of autophagosome formation to M. tuberculosis has been well studied in macrophages, but remains unclear in dendritic cells. We therefore characterized autophagosome formation in response to M. tuberculosis infection in dendritic cells. Autophagy marker protein LC3, autophagy adaptor protein p62/SQSTM1 (p62 and ubiquitin co-localized to M. tuberculosis in dendritic cells. Mycobacterial autophagosomes fused with lysosomes during infection, and major histcompatibility complex class II molecules (MHC II also localized to mycobacterial autophagosomes. The proteins p62 and Atg5 function in the initiation and progression of autophagosome formation to M. tuberculosis, respectively; p62 mediates ubiquitination of M. tuberculosis and Atg5 is involved in the trafficking of degradative vesicles and MHC II to mycobacterial autophagosomes. These results imply that the autophagosome formation to M. tuberculosis in dendritic cells promotes the antigen presentation of mycobacterial peptides to CD4(+ T lymphocytes via MHC II.

  6. Canada's Clean Air Act

    International Nuclear Information System (INIS)

    2006-01-01

    This paper provided an outline of Canada's Clean Air Act and examined some of the regulatory changes that will occur as a result of its implementation. The Act is being introduced to strengthen the legislative basis for taking action on reducing air pollution and GHGs, and will allow the government to regulate both indoor and outdoor air pollutants and GHGs. The Act will require the Ministers of the Environment and Health to establish national air quality objectives, as well as to monitor and report on their attainment. The Canadian Environmental Protection Act will be amended to enable the government to regulate the blending of fuels and their components. The Motor Vehicle Fuel Consumption Standards Act will also be amended to enhance the government's authority to regulate vehicle fuel efficiency. The Energy Efficiency Act will also be expanded to allow the government to set energy efficiency standards and labelling requirements for a wider range of consumer and commercial products. The Act will commit to short, medium and long-term industrial air pollution targets. Regulations will be proposed for emissions from industry; on-road and off-road vehicles and engines; and consumer and commercial products. It was concluded that the Government of Canada will continue to consult with provinces, territories, industries and Canadians to set and reach targets for the reduction of both indoor and outdoor air pollutants and GHG emissions. 6 figs

  7. 10 CFR 430.61 - Prohibited acts.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Prohibited acts. 430.61 Section 430.61 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CONSERVATION PROGRAM FOR CONSUMER PRODUCTS Certification and... convenience of the user, the revised text is set forth as follows: § 430.61 Prohibited acts. (b) In accordance...

  8. 77 FR 28595 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2012-05-15

    ... Power Cooperative; Great River Energy; Hoosier Energy Rural Electric Cooperative, Inc.; Indiana...-000 National Grid Transmission Services Corporation and Bangor Hydro Electric Company. Hydro H-1 P... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Sunshine Act Meeting Notice The...

  9. Energy

    International Nuclear Information System (INIS)

    Meister, F.; Ott, F.

    2002-01-01

    This chapter gives an overview of the current energy economy in Austria. The Austrian political aims of sustainable development and climate protection imply a reorientation of the Austrian energy policy as a whole. Energy consumption trends (1993-1998), final energy consumption by energy carrier (indexed data 1993-1999), comparative analysis of useful energy demand (1993 and 1999) and final energy consumption of renewable energy sources by sector (1996-1999) in Austria are given. The necessary measures to be taken in order to reduce the energy demand and increased the use of renewable energy are briefly mentioned. Figs. 5. (nevyjel)

  10. Curatorial Acts

    NARCIS (Netherlands)

    Bal, M.

    2012-01-01

    In a self-critical inquiry into my own recent work of co-curating and the experience of seeing my video work being curated by others, this article examines acts of framing as performative acts that seek to transform visitors' preconceptions. This affective effect is pursued by means of immersion,

  11. Energy

    International Nuclear Information System (INIS)

    Meister, F.

    2001-01-01

    This chapter of the environmental control report deals with the environmental impact of energy production, energy conversion, atomic energy and renewable energy. The development of the energy consumption in Austria for the years 1993 to 1999 is given for the different energy types. The development of the use of renewable energy sources in Austria is given, different domestic heat-systems are compared, life cycles and environmental balance are outlined. (a.n.)

  12. Successful implementation of the National Environmental Policy Act (NEPA) at a US Department of Energy (DOE) site: Environmental assessment preparation - a case study

    International Nuclear Information System (INIS)

    Haagenstad, T.; Ladino, A.

    1997-01-01

    The U.S. Department of Energy (DOE) at Los Alamos National Laboratory (LANL) implements the requirements of the National Environmental Policy Act (NEPA) using a NEPA Compliance Team. The NEPA Compliance Team (Team) is composed of DOE Los Alamos Area Office (LAAO) and LANL employees that combine to create quality improvements in the DOE NEPA compliance process at both LAAO and LANL. A major focus of quality improvement has been in the area of Environmental Assessment (EA) documentation preparation. The NEPA Team within LANL's Ecology Group (ESH-20) is the organization responsible for preparing the EA documentation on behalf of DOE. DOE and LANL team in an interdisciplinary process to prepare review, and complete EAs using the technical expertise of individuals throughout the DOE and LANL. This approach has demonstrated significant time and cost savings as well as EA document quality improvements. The process used to prepare an EA for the Low Energy Demonstration Accelerator (LEDA) is presented as an example of a successful approach to implementing NEPA. The LEDA EA is used as a case study example to demonstrate how an integrated and interdisciplinary approach to conducting a NEPA analysis yields extremely successful results. The LEDA EA was prepared on an extremely aggressive schedule with tight cost constraints. The ESH-20 NEPA Team was successful in providing a critical link between the DOE decision-makers and the LEDA project representatives within LANL. As the technical scope of the LEDA project changed during the preparation of the EA, by emphasizing an interdisciplinary approach, the Team was able to quickly assess the implications and potential impacts through open communications with the various subject matter experts while maintaining a pace consistent with the EA schedule demands

  13. Environmental Compliance Guide. Guidance manual for Department of Energy compliance with the Clean Water Act: National Pollutant Discharge Elimination System (NPDES)

    Energy Technology Data Exchange (ETDEWEB)

    1982-07-01

    This manual provides general guidance for Department of Energy (DOE) officials for complying with Sect. 402 of the Clean Water Act (CWA) of 1977 and amendments. Section 402 authorizes the US Environmental Protection Agency (EPA) or states with EPA approved programs to issue National Pollutant Discharge Elimination System (NPDES) permits for the direct discharge of waste from a point source into waters of the United States. Although the nature of a project dictates the exact information requirements, every project has similar information requirements on the environmental setting, type of discharge(s), characterization of effluent, and description of operations and wastewater treatment. Additional information requirements for projects with ocean discharges, thermal discharges, and cooling water intakes are discussed. Guidance is provided in this manual on general methods for collecting, analyzing, and presenting information for an NPDES permit application. The NPDES program interacts with many sections of the CWA; therefore, background material on pertinent areas such as effluent limitations, water quality standards, toxic substances, and nonpoint source pollutants is included in this manual. Modifications, variances, and extensions applicable to NPDES permits are also discussed.

  14. RECOVERY ACT: DYNAMIC ENERGY CONSUMPTION MANAGEMENT OF ROUTING TELECOM AND DATA CENTERS THROUGH REAL-TIME OPTIMAL CONTROL (RTOC): Final Scientific/Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Ron Moon

    2011-06-30

    This final scientific report documents the Industrial Technology Program (ITP) Stage 2 Concept Development effort on Data Center Energy Reduction and Management Through Real-Time Optimal Control (RTOC). Society is becoming increasingly dependent on information technology systems, driving exponential growth in demand for data center processing and an insatiable appetite for energy. David Raths noted, 'A 50,000-square-foot data center uses approximately 4 megawatts of power, or the equivalent of 57 barrels of oil a day1.' The problem has become so severe that in some cases, users are giving up raw performance for a better balance between performance and energy efficiency. Historically, power systems for data centers were crudely sized to meet maximum demand. Since many servers operate at 60%-90% of maximum power while only utilizing an average of 5% to 15% of their capability, there are huge inefficiencies in the consumption and delivery of power in these data centers. The goal of the 'Recovery Act: Decreasing Data Center Energy Use through Network and Infrastructure Control' is to develop a state of the art approach for autonomously and intelligently reducing and managing data center power through real-time optimal control. Advances in microelectronics and software are enabling the opportunity to realize significant data center power savings through the implementation of autonomous power management control algorithms. The first step to realizing these savings was addressed in this study through the successful creation of a flexible and scalable mathematical model (equation) for data center behavior and the formulation of an acceptable low technical risk market introduction strategy leveraging commercial hardware and software familiar to the data center market. Follow-on Stage 3 Concept Development efforts include predictive modeling and simulation of algorithm performance, prototype demonstrations with representative data center equipment to

  15. ACT Test

    Science.gov (United States)

    ... to clot, the higher the degree of clotting inhibition. During surgery, the ACT is kept above a ... What is ECLS? An Introduction to Extracorporeal Life Support. University of Michigan Health System [On-line information]. ...

  16. S.1269: This Act may be cited as the Renewable Hydrogen Energy Research and Development Act of 1991, introduced in the Senate of the United States, One Hundred Second Congress, First Session, June 11, 1991

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    The bill would require the Secretary of Energy to expedite the development of hydrogen derived from renewable energy sources as an alternative energy system for residential, industrial, utility, and motor vehicle use. The purposes of this bill are to reduce the US dependence on imported oil; accelerate the development of renewable hydrogen; accelerate research and development programs on components of a renewable hydrogen energy system; reduce emissions of greenhouse gases, acid rain, precursors to smog, and other air pollution; and establish industry and government cost shared projects to speed the development of renewable hydrogen energy systems

  17. MicroRNA-144-3p inhibits autophagy activation and enhances Bacillus Calmette-Guérin infection by targeting ATG4a in RAW264.7 macrophage cells.

    Science.gov (United States)

    Guo, Le; Zhou, Linlin; Gao, Qian; Zhang, Aijun; Wei, Jun; Hong, Dantong; Chu, Yuankui; Duan, Xiangguo; Zhang, Ying; Xu, Guangxian

    2017-01-01

    MicroRNAs (miRNAs) are small noncoding nucleotides that play major roles in the response of host immune cells. Autophagy plays a key role in activating the antimicrobial host defense against Mycobacterium tuberculosis (M. tuberculosis). Whether miRNAs specifically influence the activation of macrophage autophagy during M. tuberculosis infection is largely unknown. In the present study, we demonstrate that Mycobacterium bovis Bacillus Calmette-Guérin (BCG) infection of macrophages leads to increased expression of miR-144-3p, which targets autophagy-related gene 4a (ATG4a), to inhibit autophagy activation and antimicrobial responses to BCG. Overexpression of miR-144-3p significantly decreased both mRNA and protein levels of ATG4a, inhibited the formation of autophagosomes in RAW264.7 cells and increased intracellular survival of BCG. However, transfection with miR-144-3p inhibitor led to an increase in ATG4a levels, accelerated the autophagic response in macrophages, and decreased BCG survival in macrophages. The experimental results of this study reveal a novel role of miR-144-3p in inhibiting autophagy activation by targeting ATG4a and enhancing BCG infection, and provide potential targets for developing improved treatment.

  18. Energy

    International Nuclear Information System (INIS)

    Bobin, J.L.

    1996-01-01

    Object of sciences and technologies, energy plays a major part in economics and relations between nations. Jean-Louis Bobin, physicist, analyses the relations between man and energy and wonders about fears that delivers nowadays technologies bound to nuclear energy and about the fear of a possible shortage of energy resources. (N.C.). 17 refs., 14 figs., 2 tabs

  19. Energy

    CERN Document Server

    Foland, Andrew Dean

    2007-01-01

    Energy is the central concept of physics. Unable to be created or destroyed but transformable from one form to another, energy ultimately determines what is and isn''t possible in our universe. This book gives readers an appreciation for the limits of energy and the quantities of energy in the world around them. This fascinating book explores the major forms of energy: kinetic, potential, electrical, chemical, thermal, and nuclear.

  20. New governmental subsidies and taxation relief for modernization and energy conservation measures in residential and commercial buildings: the new Modernization and Energy Conservation Act. [in German]. Neue Staatszuschuesse und Steuerverguenstigungen fuer Modernisierungs- und Energieeinsparungsmassnahmen bei Wohnungen und gewerblichen Gebaeuden. Das neue Modernisierungs- und Energieeinsparungsgesetz (ModEnG)

    Energy Technology Data Exchange (ETDEWEB)

    Krautzberger, M; Eisel, R; Raff, H

    1978-01-01

    The new Modernization and Energy Conservation Act was put into force on July 1, 1978, thus providing a new legal basis for and initiating governmental promotion of constructional measures for the purpose of energy conservation. The promotion of the modernization of residential buildings was likewise extended by an amendment to the Income Tax Act. This compilation of legal regulations and explanations is not meant to serve as a legal textbook but rather as a guide for those working in trade and industry or in the administration, and for tenants and landlords interested in the subject, in order to facilitate access to the regulations governing governmental promotion of modernization and energy conservation measures.

  1. On the scope of the Federal Government to issue orders in plan approval procedures under para. 9b of the Atomic Energy Act as provided by article 85 section 3 of the Basic Law

    International Nuclear Information System (INIS)

    Ossenbuehl, F.

    1991-01-01

    Under Paragraph 9b of the Atomic Energy Act the Lower Saxonian Minister of the Environment has the competence for the plan approval procedure concerning the final disposal site Konrad. The plan approval procedure under atomic energy law is a unitary administrative procedure which makes further administrative procedures and administrative decisions superfluous on the strength of its unitary character and without impingement on constitutional law. In conducting the plan approval procedure the Lower Saxonican Minister of the Environment is acting within the framework of Laender administration on behalf of the Federation. To this extent he is subject to the orders of the Federal Minister of the Enviroment under Article 85 Section 3 of The Basic Law with respect to the formation of the procedure and procedural decisions as well as decisions on the merits pending. The concentrating effect of the plan approval procedure under atomic energy law also extends to permits under water law. (orig./HSCH) [de

  2. Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster.

    Science.gov (United States)

    Rodriguez-Fernandez, Imilce A; Dell'Angelica, Esteban C

    2015-01-01

    The Adaptor Protein (AP)-3 complex is an evolutionary conserved, molecular sorting device that mediates the intracellular trafficking of proteins to lysosomes and related organelles. Genetic defects in AP-3 subunits lead to impaired biogenesis of lysosome-related organelles (LROs) such as mammalian melanosomes and insect eye pigment granules. In this work, we have performed a forward screening for genetic modifiers of AP-3 function in the fruit fly, Drosophila melanogaster. Specifically, we have tested collections of large multi-gene deletions--which together covered most of the autosomal chromosomes-to identify chromosomal regions that, when deleted in single copy, enhanced or ameliorated the eye pigmentation phenotype of two independent AP-3 subunit mutants. Fine-mapping led us to define two non-overlapping, relatively small critical regions within fly chromosome 3. The first critical region included the Atg2 gene, which encodes a conserved protein involved in autophagy. Loss of one functional copy of Atg2 ameliorated the pigmentation defects of mutants in AP-3 subunits as well as in two other genes previously implicated in LRO biogenesis, namely Blos1 and lightoid, and even increased the eye pigment content of wild-type flies. The second critical region included the ArfGAP1 gene, which encodes a conserved GTPase-activating protein with specificity towards GTPases of the Arf family. Loss of a single functional copy of the ArfGAP1 gene ameliorated the pigmentation phenotype of AP-3 mutants but did not to modify the eye pigmentation of wild-type flies or mutants in Blos1 or lightoid. Strikingly, loss of the second functional copy of the gene did not modify the phenotype of AP-3 mutants any further but elicited early lethality in males and abnormal eye morphology when combined with mutations in Blos1 and lightoid, respectively. These results provide genetic evidence for new functional links connecting the machinery for biogenesis of LROs with molecules implicated in

  3. The 15th German Atomic Energy Act Amendment to the implementation of the EURATOM nuclear safety directive; Die 15. AtG-Novelle zur Umsetzung der EURATOM-Sicherheits-Richtlinie

    Energy Technology Data Exchange (ETDEWEB)

    Mueller-Dehn, Christian [PreussenElektra GmbH, Hannover (Germany)

    2017-06-15

    The 15th German Atomic Energy Act Amendment has now passed the parliamentary legislative procedure with the decision of the Bundestag in the third reading of 30 March 2017. The publication in the Federal Law Gazette (Bundesgesetzblatt) is still pending. The background of the amendment is the addition to the Euratom safeguards directive adopted by the European Council in July 2014. This directive has to be implemented in the national regulations of the EURATOM Member States. However, since most of these supplements were already standard in German atomic law, the regulatory requirements for Germany were low. This is also explicitly stated in the statement to the act.

  4. H.R. 2662: This Act may be cited as the Department of Energy Nuclear Contractors Accountability and Award System Act of 1989. Introduced in the House of Representatives, One Hundredth First Congress, First Session, June 15, 1989

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    H.R. 2662 is a bill to prohibit the Department of Energy from paying fines or penalties assessed against national security program contractors for violation of laws or regulations and to direct the Secretary of Energy to revise the system of award fees to such contractors to encourage discovery and remedy of conditions and practices that could lead to such violations

  5. YUCCA MOUNTAIN PROJECT RECOMMENDATION BY THE SECRETARY OF ENERGY REGARDING THE SUITABILITY OF THE YUCCA MOUNTAIN SITE FOR A REPOSITORY UNDER THE NUCLEAR WASTE POLICY ACT OF 1982

    Energy Technology Data Exchange (ETDEWEB)

    NA

    2002-03-26

    For more than half a century, since nuclear science helped us win World War II and ring in the Atomic Age, scientists have known that !he Nation would need a secure, permanent facility in which to dispose of radioactive wastes. Twenty years ago, when Congress adopted the Nuclear Waste Policy Act of 1982 (NWPA or ''the Act''), it recognized the overwhelming consensus in the scientific community that the best option for such a facility would be a deep underground repository. Fifteen years ago, Congress directed the Secretary of Energy to investigate and recommend to the President whether such a repository could be located safely at Yucca Mountain, Nevada. Since then, our country has spent billions of dollars and millions of hours of research endeavoring to answer this question. I have carefully reviewed the product of this study. In my judgment, it constitutes sound science and shows that a safe repository can be sited there. I also believe that compelling national interests counsel in favor of proceeding with this project. Accordingly, consistent with my responsibilities under the NWPA, today I am recommending that Yucca Mountain be developed as the site for an underground repository for spent fuel and other radioactive wastes. The first consideration in my decision was whether the Yucca Mountain site will safeguard the health and safety of the people, in Nevada and across the country, and will be effective in containing at minimum risk the material it is designed to hold. Substantial evidence shows that it will. Yucca Mountain is far and away the most thoroughly researched site of its kind in the world. It is a geologically stable site, in a closed groundwater basin, isolated on thousands of acres of Federal land, and farther from any metropolitan area than the great majority of less secure, temporary nuclear waste storage sites that exist in the country today. This point bears emphasis. We are not confronting a hypothetical problem. We have a

  6. YUCCA MOUNTAIN PROJECT RECOMMENDATION BY THE SECRETARY OF ENERGY REGARDING THE SUITABILITY OF THE YUCCA MOUNTAIN SITE FOR A REPOSITORY UNDER THE NUCLEAR WASTE POLICY ACT OF 1982

    International Nuclear Information System (INIS)

    2002-01-01

    For more than half a century, since nuclear science helped us win World War II and ring in the Atomic Age, scientists have known that the Nation would need a secure, permanent facility in which to dispose of radioactive wastes. Twenty years ago, when Congress adopted the Nuclear Waste Policy Act of 1982 (NWPA or ''the Act''), it recognized the overwhelming consensus in the scientific community that the best option for such a facility would be a deep underground repository. Fifteen years ago, Congress directed the Secretary of Energy to investigate and recommend to the President whether such a repository could be located safely at Yucca Mountain, Nevada. Since then, our country has spent billions of dollars and millions of hours of research endeavoring to answer this question. I have carefully reviewed the product of this study. In my judgment, it constitutes sound science and shows that a safe repository can be sited there. I also believe that compelling national interests counsel in favor of proceeding with this project. Accordingly, consistent with my responsibilities under the NWPA, today I am recommending that Yucca Mountain be developed as the site for an underground repository for spent fuel and other radioactive wastes. The first consideration in my decision was whether the Yucca Mountain site will safeguard the health and safety of the people, in Nevada and across the country, and will be effective in containing at minimum risk the material it is designed to hold. Substantial evidence shows that it will. Yucca Mountain is far and away the most thoroughly researched site of its kind in the world. It is a geologically stable site, in a closed groundwater basin, isolated on thousands of acres of Federal land, and farther from any metropolitan area than the great majority of less secure, temporary nuclear waste storage sites that exist in the country today. This point bears emphasis. We are not confronting a hypothetical problem. We have a staggering amount of

  7. S.1225: a Bill to amend the Atomic Energy Act of 1954. Introduced in the Senate of the United States, Ninety-Ninth Congress, First Session, May 24, 1985

    International Nuclear Information System (INIS)

    1985-01-01

    The Price-Anderson Act Amendments Act of 1985 (S.1225) amends the Atomic Energy Act of 1954 by incorporating past experiences and new developments into a fair and efficient system for compensating the public when there is an accident involving nuclear materials. Licensees under the Nuclear Regulatory Commission must carry liability insurance only to the extent that private sources can provide, although large nuclear power plants can combine financial protection from a variety of self-insurance and external sources. The bill describes a retrospective rating plan for allocating premiums and procedures for deferring premiums. There are provisions for compensation in the event of liabilities incurred during periods of storage, transfer, or disposal of spent nuclear fuel. No more than $100 million will be available in the compensation for incidents outside the US. If enacted, the indemnification period extends from August 30, 1954 to August 1, 2012

  8. Energy

    CERN Document Server

    Robertson, William C

    2002-01-01

    Confounded by kinetic energy? Suspect that teaching about simple machines isn t really so simple? Exasperated by electricity? If you fear the study of energy is beyond you, this entertaining book will do more than introduce you to the topic. It will help you actually understand it. At the book s heart are easy-to-grasp explanations of energy basics work, kinetic energy, potential energy, and the transformation of energy and energy as it relates to simple machines, heat energy, temperature, and heat transfer. Irreverent author Bill Robertson suggests activities that bring the basic concepts of energy to life with common household objects. Each chapter ends with a summary and an applications section that uses practical examples such as roller coasters and home heating systems to explain energy transformations and convection cells. The final chapter brings together key concepts in an easy-to-grasp explanation of how electricity is generated. Energy is the second book in the Stop Faking It! series published by NS...

  9. Energy

    International Nuclear Information System (INIS)

    1975-10-01

    On the occasion of the World Environment Day the Norwegian Ministry for the Environment held a conference on growth problems in energy consumption. The themes which were treated were energy conservation, hydroelectric power, the role of nuclear power, radioactive waste disposal, fossil fuel resources, ecological limits, pollution and international aspects. Nuclear energy forms the main theme of one lecture and an aspect of several others. (JIW)

  10. Energy

    OpenAIRE

    Torriti, Jacopo

    2016-01-01

    The impact of energy policy measures has been assessed with various appraisal and evaluation tools since the 1960s. Decision analysis, environmental impact assessment and strategic environmental assessment are all notable examples of progenitors of Regulatory Impact Assessment (RIA) in the assessment of energy policies, programmes and projects. This chapter provides overview of policy tools which have been historically applied to assess the impacts of energy policies, programmes and projects....

  11. Energies

    International Nuclear Information System (INIS)

    2003-01-01

    In the framework of the National Debate on the energies in a context of a sustainable development some associations for the environment organized a debate on the nuclear interest facing the renewable energies. The first part presents the nuclear energy as a possible solution to fight against the greenhouse effect and the associated problem of the wastes management. The second part gives information on the solar energy and the possibilities of heat and electric power production. A presentation of the FEE (French wind power association) on the situation and the development of the wind power in France, is also provided. (A.L.B.)

  12. Process for Transition of Uranium Mill Tailings Radiation Control Act Title II Disposal Sites to the U.S. Department of Energy Office of Legacy Management for Long-Term Surveillance and Maintenance

    Energy Technology Data Exchange (ETDEWEB)

    None

    2012-03-01

    This document presents guidance for implementing the process that the U.S. Department of Energy (DOE) Office of Legacy Management (LM) will use for assuming perpetual responsibility for a closed uranium mill tailings site. The transition process specifically addresses sites regulated under Title II of the Uranium Mill Tailings Radiation Control Act (UMTRCA) but is applicable in principle to the transition of sites under other regulatory structures, such as the Formerly Utilized Sites Remedial Action Program.

  13. H.R.1301: A bill to implement the National Energy Strategy Act, and for other purposes, introduced in the US House of Representatives, One Hundred Second Congress, First Session, March 6, 1991

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    This bill contains the following: Title I - Residential, commercial, and Federal energy use: consumer and commercial products, and Federal energy management; Title II - Natural gas: natural gas pipeline regulatory reform, natural gas import/export deregulation, and structural reform of the Federal Energy Regulatory Commission; Title III - Oil: Alaska coastal plain oil and gas leasing, Naval Petroleum Reserve leasing, and oil pipeline deregulation; Title IV - Electricity generation and use: Public Utility Holding Company Act reform, and power marketing administration repayment reform; Title V - Nuclear power: licensing reform, nuclear waste management; Title VI - Renewable energy: PURPA size cap and co-firing reform, and hydroelectric power regulatory reform; Title VII - Alternative fuel: alternative and dual fuel vehicle credits, and alternative transportation fuels; Title VIII - Innovation and technology transfer; Title IX - Tax incentives

  14. 75 FR 64306 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2010-10-19

    ... Transmission System. Hydro H-1 P-12107-005 Granite County, Montana. H-2 P-2496-222 Eugene Water and Electric... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Sunshine Act Meeting Notice October 14... Sunshine Act (Pub. L. 94-409), 5 U.S.C. 552b: Agency Holding Meeting: Federal Energy Regulatory Commission...

  15. No 592 - Radiation Act

    International Nuclear Information System (INIS)

    1991-01-01

    This Act will enter into force on 1 January 1992. The scope of the Act is extensive as, in addition to ionizing radiation, it will also apply to activities involving exposure to natural radiation and non-ionizing radiation. Its purpose is to prevent and restrict harmful effects to health resulting from radiation. The basic principles of the Act are that the practice involving radiation should be justified; radiation protection should be optimized; and radiation doses should be as low as reasonably achievable. Licensed organisations using radiation will be responsible for the safety of the activity involving exposure to radiation and for having available the appropriate expertise to this effect. The required so-called safety licence provides the regulatory control to ensure that radiation is used sensibly, that the equipment and shields are technically acceptable and the operating personnel is competent, and that the radioactive waste is dealt with appropriately. The Radiation Act will also apply to nuclear activities within the scope of the 1987 Nuclear Energy Act [fr

  16. Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3 Mutants in Drosophila melanogaster.

    Directory of Open Access Journals (Sweden)

    Imilce A Rodriguez-Fernandez

    Full Text Available The Adaptor Protein (AP-3 complex is an evolutionary conserved, molecular sorting device that mediates the intracellular trafficking of proteins to lysosomes and related organelles. Genetic defects in AP-3 subunits lead to impaired biogenesis of lysosome-related organelles (LROs such as mammalian melanosomes and insect eye pigment granules. In this work, we have performed a forward screening for genetic modifiers of AP-3 function in the fruit fly, Drosophila melanogaster. Specifically, we have tested collections of large multi-gene deletions--which together covered most of the autosomal chromosomes-to identify chromosomal regions that, when deleted in single copy, enhanced or ameliorated the eye pigmentation phenotype of two independent AP-3 subunit mutants. Fine-mapping led us to define two non-overlapping, relatively small critical regions within fly chromosome 3. The first critical region included the Atg2 gene, which encodes a conserved protein involved in autophagy. Loss of one functional copy of Atg2 ameliorated the pigmentation defects of mutants in AP-3 subunits as well as in two other genes previously implicated in LRO biogenesis, namely Blos1 and lightoid, and even increased the eye pigment content of wild-type flies. The second critical region included the ArfGAP1 gene, which encodes a conserved GTPase-activating protein with specificity towards GTPases of the Arf family. Loss of a single functional copy of the ArfGAP1 gene ameliorated the pigmentation phenotype of AP-3 mutants but did not to modify the eye pigmentation of wild-type flies or mutants in Blos1 or lightoid. Strikingly, loss of the second functional copy of the gene did not modify the phenotype of AP-3 mutants any further but elicited early lethality in males and abnormal eye morphology when combined with mutations in Blos1 and lightoid, respectively. These results provide genetic evidence for new functional links connecting the machinery for biogenesis of LROs with

  17. Portfolio of patents after the Brazilian Innovation Act: the case of the Comissao Nacional de Energia Nuclear - CNEN (Brazilian National Nuclear Energy Commission)

    International Nuclear Information System (INIS)

    Pereira, Gustavo Jose; Guimaraes, Regia Ruth Ramirez; Perry, Katia da Silva Peixoto; Teruya, Dirceu Yoshikazu

    2013-01-01

    The process of technological development is due to the need to promote a solution to a particular problem of agents, compete with products and/or processes on the international market and to promote scientific advancement. Thus, the patent system is a repository of knowledge for protection, for promotion of diffusion through licensing agreements and an indicator of technological development. In 2004, the Brazilian Government enacted the Brazilian Innovation Act and the mechanisms were improved for cooperation between firms and public education, science and technology organisations and also promoted the commercialisation of technology produced by public education, science and technology organisations and the mandatory establishment of Technology Transfer Offices. The Comissao Nacional de Energia Nuclear (CNEN) is a federal agency responsible for basic and applied research in the field of nuclear technology and has used the patent system since the 1980s to protect its knowledge. With the advent of the Innovation Act in 2004, there was a significant boost in requests for patents in CNEN which also established an internal set of normative acts and created a System of Innovation Management and Technology Innovation Offices in its research institutes to support management and dissemination of knowledge. The aim of this case study is to present the profile of the requests for patents by CNEN before and after the enactment of the Brazilian Innovation Act covering the period of time between 1980 and 2010. (author)

  18. Administrative Changes (Consequentia Provisions) Act 1978, No. 36 of 1978

    International Nuclear Information System (INIS)

    1978-01-01

    This Act which amends a series of Acts from the administrative viewpoint also amends the 1953 Atomic Energy Act by laying down that, wherever mentioned, the Treasurer must be substituted by the Minister of Finance. (NEA) [fr

  19. Pacific Northwest Electric Power Planning and Conservation Act : Legislative History of the Act to Assist the Electrical Consumers of the Pacific Northwest through use of the Federal Columbia River Power System to Achieve Cost-Effective Energy Conservation : P.L. 96-501, 94 Stat. 2697.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1981-01-01

    The Pacific Northwest Electric Power Planning and Conservation Act became effective when it was signed into law by President Carter on December 5, 1980. This ended a four-year debate over legislation designed to plan and coordinate the region's energy future. This legislative history is an abbreviated version taken from the larger historical file maintained by the BPA Law Library. It is intended to assist BPA personnel and others who are studying the Northwest Power Act and working on its implementation. The documents included were selected for their value in determining what Congress meant in enacting the statute and to provide the researcher with a starting point for further investigation. These documents include: a history of the Act, a chronology of the legislative action leading to passage of the law; a section-by-section analysis of the Act; the Congressional Records of Senate and House debates on the bill and its amendments, and a list of Congressional committee hearings.

  20. Moderate Autophagy Inhibits Vascular Smooth Muscle Cell Senescence to Stabilize Progressed Atherosclerotic Plaque via the mTORC1/ULK1/ATG13 Signal Pathway

    Directory of Open Access Journals (Sweden)

    Zhenli Luo

    2017-01-01

    Full Text Available In order to investigate the effects of autophagy induced by rapamycin in the development of atherosclerosis plaque we established murine atherosclerosis model which was induced in ApoE−/− mice by high fat and cholesterol diet (HFD for 16 weeks. Rapamycin and 3-Methyladenine (MA were used as autophagy inducer and inhibitor respectively. The plaque areas in aortic artery were detected with HE and Oil Red O staining. Immunohistochemical staining were applied to investigate content of plaque respectively. In contrast to control and 3-MA groups, rapamycin could inhibit atherosclerosis progression. Rapamycin was able to increase collagen content and a-SMA distribution relatively, as well as decrease necrotic core area. Then we used MOVAS and culture with ox-LDL for 72 h to induce smooth muscle-derived foam cell model in vitro. Rapamycin and 3-MA were cultured together respectively. Flow cytometry assay and SA-β-Gal staining experiments were performed to detect survival and senescence of VSMCs. Western blot analysis were utilized to analyze the levels of protein expression. We found that rapamycin could promote ox-LDL-induced VSMCs autophagy survival and alleviate cellular senescence, in comparison to control and 3-MA groups. Western blot analysis showed that rapamycin could upregulate ULK1, ATG13 and downregulate mTORC1 and p53 protein expression.

  1. Stress and phase changes in a low-thermal-expansion Al-3at.%Ge alloy film on oxidized silicon wafers

    International Nuclear Information System (INIS)

    Tu, K.N.; Rodbell, K.P.; Herd, S.R.; Mikalsen, D.J.

    1993-01-01

    The alloy of Al-3at.%Ge has been found to have a low thermal expansion and contraction in the temperature range of room temperature to 400 C. The reason for the low thermal contraction (or expansion) is the precipitation (or dissolution) of Ge in the alloy. The Ge precipitates have a diamond structure in which each Ge atom occupies a much larger atomic volume than a Ge atom dissolved substitutionally in Al. The volume difference compensates for the effect of thermal expansion and contraction with changing temperature which in turn reduces the thermal stress due to thermal mismatch. The technique of wafer bending was used to determine the stress of the alloy film on oxidized silicon wafers upon thermal cycling; indeed, it is much lower than that of pure Al on identical wafers. The morphology of precipitation and dissolution of Ge in Al has been studied by transmission and scanning electron microscopy. It is found that the precipitation follows a discontinuous mode and occurs predominantly along grain boundaries. In dissolving the Ge precipitates into Al, voids are left behind because of the volume difference. It is proposed that this may explain the enhancement of nucleation of voids in the alloy film upon thermal cycling. (orig.)

  2. Reasons for decision in the matter of Altresco Pittsfield L.P., Crestar Energy, Enron Capital and Trade Resources Corp. applications pursuant to Part VI of the National Energy Board Act of Licences to Export Natural Gas and, Husky Oil Operations Ltd., application pursuant to section 32 of the National Energy Board Act to amend a Licence to Export Natural Gas. Vol. 1

    International Nuclear Information System (INIS)

    1996-01-01

    Basis for the National Energy Board's decisions in four gas export applications were presented. Gas export applications were discussed in general terms, followed by a review of each of the four applications. (Altreso Pittsfield L.P., Crestar Energy, Enron Capital and Trade Resources Corp., and Husky Oil Operations Ltd). The reviews took into account the current gas supply, transportation, markets, gas sales contracts, and the status of regulatory authorizations. All four applications were approved. The terms and conditions of the licences to be issued were reproduced in Appendix 1. 1 tab

  3. Energy Theater

    Science.gov (United States)

    Daane, Abigail R.; Wells, Lindsay; Scherr, Rachel E.

    2014-01-01

    Energy Theater is a dynamic, full-body activity that engages all students in representing the flow of energy in various phenomena, such as a light bulb burning steadily or a refrigerator cooling food. In Energy Theater, each participant acts as a unit of energy that has one form at a time. Regions on the floor correspond to objects in a physical…

  4. Clean Air Act Amendments of 1990: Impacts on natural gas markets. Summary of the annual GRI Energy Seminar (12th) for the GRI Board of Directors and Advisory Council. Held in Asheville, North Carolina on August 12-14, 1991

    International Nuclear Information System (INIS)

    Farrell, M.D.

    1991-01-01

    Each year, Gas Research Institute (GRI) conducts an energy seminar for its Board of Directors and Advisory Council on an issue of timely importance to the gas industry. The topic selected for the Twelfth Annual GRI Energy Seminar was 'Clean Air Act Amendments of 1990: Impacts on Natural Gas Markets.' The two sessions of the seminar focused upon the sectors of the energy market most significantly affected by the legislation. Session I: Fuel Choices for Stationary Applications explored the impact of the Clean Air Act Amendments upon stationary, fuel-burning applications, particularly power plants. The current outlook for bringing existing coal-fired power plants into conformance with the law and the significance of the provisions for the choice of fuels for major future fuel-burning facilities were discussed, along with the impact of the provisions upon GRI's strategies and the technical and economic targets for ongoing R and D. Session II: The Emerging Alternative-Fuel Vehicle Market addressed the significance of the new requirements to the outlook for compressed natural gas vehicles and the suitability of GRI's methane vehicle R and D strategy to the revised outlook. The report summarizes the presentations and discussions at the seminar

  5. S. 1514: This Act may be cited as the Department of Energy National Security Act for Fiscal Years 1992 and 1993, introduced in the United States Senate, One Hundred Second Congress, First Session, July 22, 1991

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Title 31, Part A, National Security Programs Authorizations, includes the following sections: Operating Expenses; Plant and Capital Equipment; Environmental Restoration and Waste Management; Funding Limitations; and General Reduction in Authorizations. Part B, Recurring General Provisions, presents the following Sections: Reprogramming; Limits on General Plant Projects; Limits on construction Projects; Fund Transfer Authority; Authority for Construction Design; Authority for Emergency Construction, Design and Construction Activities; and Funds Available for all DOE National Security Programs. Part C, Miscellaneous, includes the following: Scholarship and Fellowship Program for Environmental Restoration and Waste Management; Defense Environmental Restoration and Waste Management Program; Private Sector Participation in Waste Cleanup and Modernization Activities; Career Development Program for National Laboratory Employees; Resumption of Plutonium Operations at Rocky Flats Plant; Training and Protection of Nuclear Facilities Workers Who Respond to Emergencies Related to Hazardous Substances; and DOE Partnerships for Energy Critical Technologies, Advanced Manufacturing Technology, and Materials Processing, Synthesis, and Commercialization. Title 22, Defense Nuclear Facilities Safety Board Authorization, notes funds authorized for the board and discusses briefly changes in its powers and functions

  6. Decree of 16 October 1969, Stb. 472, concerning the implementation of Sections 27 and 58, paragraph 5 of the Nuclear Energy Act (Registration of Radioactive Materials and Food and Drugs Inspectorate Charges)

    International Nuclear Information System (INIS)

    1969-01-01

    Under the Nuclear Energy Act, any person who prepares, transports, uses or dumps radioactive materials must keep a register concerning the materials and theses operations. This Decree stipulates that the register must be kept in such a way as to show clearly which radioactive materials subject to registration are present within the area under the jurisdiction of the food and drug inspectorates concerned. It also lays down rules concerning provision of information from the register and financing the cost of the food and drug inspectorates. (NEA) [fr

  7. The CAT-ACT Beamline at ANKA: A new high energy X-ray spectroscopy facility for CATalysis and ACTinide research

    Science.gov (United States)

    Zimina, A.; Dardenne, K.; Denecke, M. A.; Grunwaldt, J. D.; Huttel, E.; Lichtenberg, H.; Mangold, S.; Pruessmann, T.; Rothe, J.; Steininger, R.; Vitova, T.

    2016-05-01

    A new hard X-ray beamline for CATalysis and ACTinide research has been built at the synchrotron radiation facility ANKA. The beamline design is dedicated to X-ray spectroscopy, including ‘flux hungry’ photon-in/photon-out and correlative techniques with a special infrastructure for radionuclide and catalysis research. The CAT-ACT beamline will help serve the growing need for high flux/hard X-ray spectroscopy in these communities. The design, the first spectra and the current status of this project are reported.

  8. Act No. 160 of 17 March 1979 containing regulations approving the Paris Convention of 29 July 1960 on Third Party Liability in the Field of Nuclear Energy and its Additional Protocol of 28 January 1964 as well as the Brussels Convention of 31 January 1963 supplementary to the Paris Convention and its Additional Protocol of 28 January 1964

    International Nuclear Information System (INIS)

    1979-01-01

    By this Act the Netherlands approved the 1960 Paris Convention on Third Party Liability in the Field of Nuclear Energy, as well as the Brussels Convention of 1963 Supplementary to that Convention. This Act came into force on 28 December 1979 thus bringing into force on that date the Paris Convention and the Brussels Supplementary Convention in the Netherlands. (NEA) [fr

  9. The ''state of the art in science'' examined as a concept of law from the angle of epistemology, with the example of the principle of averting danger, as defined in the emission control law and in the atomic energy law

    International Nuclear Information System (INIS)

    Lohse, D.

    1994-01-01

    The term ''state of the art in science'' is the essential element guaranteeing the legally required measures for averting danger during specified normal operation and in case of an accident, as defined in the Atomic Energy Act and in the Federal Emission Control Act. The literature, jurisdiction, and the licensing practice are not unanimous in the interpretation of the content of this term ''state of the art in science'', its function in the licensing procedure, and its distinctions as compared to the term ''state of the art in technology''. The book in hand sets out to provide answers. The term state of the art in science appears at different places in the Atomic Energy Act (AtG) or the Federal Emission Control Act (BImSchG), and in different factual contexts. Reference to the measures for averting danger offers the possibility of gearing to a specific context of this term and thus to discuss the term in a selected context. The principle of averting danger therefore offers the factual frame for an epistemological examination of the term ''state of the art in science''. Other than the Federal Constitutional Court in its Kalkar reactor judgment, the author's opinion is that the limits of the human capacity of knowledge are not due to theoretical capacities, but rather to practical. The aquired knowledge thus lags behind the knowledge achievable from the angle of epidemology. The remaining uncertainty in the author's theory thus is larger than that assumed in the judgment of the Federal Constitutional Court. The limits of the human capacity of knowledge, the author says, cannot be regarded to likewise set the same limits to the principle or instrument of averting danger. The limits of averting danger are a result of the administrative capacities. (orig.) [de

  10. Recovery Act: Federspiel Controls (now Vigilent) and State of California Department of General Services Data Center Energy Efficient Cooling Control Demonstration. Final technical project report

    Energy Technology Data Exchange (ETDEWEB)

    Federspiel, Clifford; Evers, Myah

    2011-09-30

    Eight State of California data centers were equipped with an intelligent energy management system to evaluate the effectiveness, energy savings, dollar savings and benefits that arise when powerful artificial intelligence-based technology measures, monitors and actively controls cooling operations. Control software, wireless sensors and mesh networks were used at all sites. Most sites used variable frequency drives as well. The system dynamically adjusts temperature and airflow on the fly by analyzing real-time demands, thermal behavior and historical data collected on site. Taking into account the chaotic interrelationships of hundreds to thousands of variables in a data center, the system optimizes the temperature distribution across a facility while also intelligently balancing loads, outputs, and airflow. The overall project will provide a reduction in energy consumption of more than 2.3 million kWh each year, which translates to $240,000 saved and a reduction of 1.58 million pounds of carbon emissions. Across all sites, the cooling energy consumption was reduced by 41%. The average reduction in energy savings across all the sites that use VFDs is higher at 58%. Before this case study, all eight data centers ran the cooling fans at 100% capacity all of the time. Because of the new technology, cooling fans run at the optimum fan speed maintaining stable air equilibrium while also expending the least amount of electricity. With lower fan speeds, the life of the capital investment made on cooling equipment improves, and the cooling capacity of the data center increases. This case study depicts a rare technological feat: The same process and technology worked cost effectively in eight very different environments. The results show that savings were achieved in centers with diverse specifications for the sizes, ages and types of cooling equipment. The percentage of cooling energy reduction ranged from 19% to 78% while keeping temperatures substantially within the

  11. H.R. 5448: a bill to amend the Atomic Energy Act of 1954, as amended, to reorganize the functions of the Nuclear Regulatory Commission by abolishing the Commission and in its place establishing the Nuclear Regulation and Safety Agency. Introduced in the House of Representatives, Ninety-Ninth Congress, Second Session, August 15, 1986

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    The Omnibus Nuclear Safety Act of 1986 amends the Atomic Energy Act of 1954 by replacing the Nuclear Regulatory Commission with a new entity, the Nuclear Regulation and Safety Agency. The purposes are to promote an energy policy that is better coordinated and more consistent with the protection of public health and safety. The new agency would also expedite licensing for construction and operation of nuclear power plants by using pre-approved standardized designs and sites

  12. Adjustment of Energy requirements in TEK; TEK= Technical Regulations under the Norwegian Planning and Building Act; Justering av energikrav i TEK

    Energy Technology Data Exchange (ETDEWEB)

    Thyholt, Marit; Dokka, Tor Helge; Schild, Peter; Grini, Catherine; Mysen, Mads; Sartori, Igor

    2008-07-01

    The National Office of Building Technology and Administration (BE) desired to review the consequences of different levels of ambition for requirements for heat gaining from vent air, as well as a possible requirement for energy efficient design of building fronts. In addition the energy scope in the regulation (TEK2007) should be adjusted according to the final establishment of a new calculation standard (Norwegian Standard - NS 3031:2007). A statement on these subjects has been carried out at SINTEF Byggforsk, and is described in this report. Adjustments of framework regulations.There are only minor differences between adjusted calculations according to NS 3031 and the original energy framework calculations, i.e. the difference for net energy need amounts to the size of 0 to 6 percent. Heat gain.The report shows that it is possible - both from techical and financial considerations - to increase the requirement level for heat gain from vent air for most categories of buildings. This implies a sharpening of the annual median temperature efficiency from 70 % to 80 %, for all building categories, except from hospitals, institutions and light industry/workshops. A possible sharpening of regulations for heat gain in houses has not been evaluated. Depending on building category a sharpening of regulations for heat gain from vent air will imply that net energy need will be reduced on a scale of 20 to 30 kWh/m2 per annum. The report demonstrates that despite a possible sharpening of the requirements on energy efficiency for heat recovery devices does not prevent the use of large areas of windows and window panes. Vulnerability analyses show that deviations from the prerequisites in the basis for the energy framework concerning air quantities and air temperatures give the possibility of weakening the building's heating characteristics. Building fronts. Different methods for added requirements for building fronts have been examined. The aim has been to find methods and

  13. S.743: A bill entitled the National Energy Efficiency and Development Tax Act of 1991, introduced in the Senate of the United States, One Hundred Second Congress, First Session, March 21, 1991

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    The bill would amend certain sections of the Internal Revenue Act to provide tax incentives for renewable energy production. Qualified technologies include solar thermal, photovoltaic, wind, geothermal (other than dry steam), and biomass. The bill would also limit exclusion from gross income for parking and allow exclusion for employer subsidies for mass transit and van pooling. A tax credit would be allowed for retrofitting of home oil heaters. The bill would allow exclusion from gross income for energy and water conservation subsidies provided by public utilities. The Safe and Efficient Vehicles Incentive Act of 1991 is included in this bill. The net income limitation on percentage depletion would not apply to oil and gas wells and a crude oil production credit would be available for maintaining economically marginal wells. There is a credit for crude oil and natural gas exploration and development and the intangible drilling costs would be removed from the Alternative Minimum Tax. Several other credits for the petroleum industry are described

  14. 76 FR 71013 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2011-11-16

    .......... North American Electric Reliability Corporation. E-6 RC11-1-001........ Cedar Creek Wind Energy, LLC...-2576-151........ FirstLight Hydro Generating Company. H-3 P-2601-015........ Duke Energy Carolinas, LLC... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Sunshine Act Meeting Notice November 10...

  15. S. 1225: to bill to amend the Atomic Energy Act of 1954, as amended, to establish a comprehensive, equitable, reliable, and efficient mechanism for full compensation of the public in the event of an accident. Introduced in the Senate of the United States, Ninety-Ninth Congress, Second Session, May 24, 1985

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    The Price-Anderson Act Amendments of 1985 amend the Atomic Energy Act of 1954 to establish a comprehensive, equitable, reliable, and efficient mechanism for full compensation of the public in the event of an accident. The amended Act sets the amount of financial protection required as the amount of liability insurance available from private sources, with power plants having a rated capacity of 100,000 KWe or more required to have the maximum amount available at reasonable cost. The Act also changes the terms of indemnification agreements for activities done under contract to DOE

  16. The energy turnaround is in progress. The EEWaermeG (Erneuerbare-Energien-Waermegesetz, Act on Power Generation from Renewable Energy Sources) and its consequences; Die Energiewende ist eingelaeutet. Das Erneuerbare-Energien-Waermegesetz (EEWaermeG) und seine Folgen

    Energy Technology Data Exchange (ETDEWEB)

    Mardo, Dietrich

    2009-06-29

    The Erneuerbare-Energien-Waermegesetz (EEG) is the first legislation ever that dictates the use of renewable energy sources for new buildings. By 2020, the share of renewables in end use energy consumption is to amount to 14 %. The new law came into force on 1 January 2009 and has initiated all kinds of prognoses. It appears that a world-wide energy revolution may have begun. This is the first of a series of articles in ISOLIERTECHNIK on all relevant renewable energy sources. (orig.)

  17. Decree of 20 October 1969, Stb. 476, concerning the implementation of Sections 14, 21, 28, 32, 34 and 75 of the Nuclear Energy Act (National Defense (Exemption))

    International Nuclear Information System (INIS)

    1969-01-01

    Under this Decree, no licence is required concerning fissionable materials, ores and radioactive materials, as well as establishments or equipment for use by the Netherlands Armed Forces or the Armed Forces of an allied country. However, exemptions from licensing under the Decree are without prejudice to the general provisions of the Nuclear Energy (Radioactive Materials) Decree and in the Fissionable Materials, Ores and Radioactive Materials (Transport) Decree. (NEA) [fr

  18. Life extension of German nuclear power plants only with the consent of the Federal Council? The importance and extent of the need for consent to an amendment to the German Atomic Energy Act

    International Nuclear Information System (INIS)

    Schneider, Horst

    2010-01-01

    In its coalition agreement of October 26, 2009, the new German federal government plans ''to extend the service life of German nuclear power plants while, at the same time, complying with the strict German and international safety standards.'' This has triggered a debate not only about (nuclear) energy, as in the past election campaign in the summer of 2009, but also about the constitutional law issue whether an amendment to the Atomic Energy Act resulting in longer operating life of nuclear power plants required the consent of the Federal Council (the ''Bundesrat,'' the second chamber of parliament). After the election to the state parliament in North Rhine-Westphalia on May 9, 2010, majority in the Federal Council changed. As a consequence, no consent to an amendment to the Atomic Energy Act must be expected. In view of the large number of recent statements about constitutional law in opinions for various federal and ministerial accounts as well as firms and associations, the outline by R. Scholz in the May issue of atw 2010 will be followed in this issue by the key points of examination of the need for consent, under aspects of constitutional law, and an attempt will be made to explain the evaluations underlying the generation of a legal concept about these items. The decision by the German Federal Constitutional Court of May 4, 2010, published on June 11, 2010, plays a major role in this respect because it established clarity in some important aspects of a legal subject matter in the field of state admini-stration on behalf of the federation, albeit in the field of air traffic law, not nuclear law. However, the structures of the norms in the German Basic Law (Art. 87c and Art. 87d, para.2) to be applied are almost identical. The energy policy and energy economy aspects of a plant life extension are considered along with the option of an appeal to the Federal Constitutional Court against any plant life extension. Finally, the key findings are summarized briefly

  19. Administrative changes (Consequential Provisions) Act 1976, No. 91

    International Nuclear Information System (INIS)

    1976-01-01

    This Act which amends a series of Acts from the viewpoint of administrative changes also amends the Atomic Energy Act 1953 by laying down that the Territories of Papua and New Guinea are henceforth to be omitted from the list of Territories for which the Atomic Energy Commission must obtain approval from the competent Minister before exercising its powers. (NEA) [fr

  20. Nevada state and local government comments on the US Department of Energy's report to Congress pursuant to Section 175 of the Nuclear Waste Policy Act, as amended

    International Nuclear Information System (INIS)

    1989-03-01

    The State of Nevada and affected local governments and Indian Tribes recognize the difficulties Department of Energy (DOE) encountered in attempting to compile a meaningful report on possible repository-related impacts in the relatively short amount of time available for the task. Overall, the Section 175 Report represents a positive beginning in what must, necessarily, be a much more thorough and detailed impact assessment effort. Although the current Report Does not identify the full range of repository impacts, nor seek to quantify them, it is useful as a framework or scoping document which, when supplemented with information on the specifics of impacts and costs/strategies for mitigation, may be useful in understanding the effects a repository will have upon the State of Nevada and affected communities. Subsequent socioeconomic analyses should follow-up this positive beginning and specify in greater detail the areas where undefined impacts may occur. Such analyses should expand the geographic scope of the Report, address transportation impacts along potential high-level waste routes, complete the project description (i.e., uncertainties with regard to labor force, materials requirements, etc.) used in forecasting effects within various categories of impacts, refine the section on impact mitigation strategies, and give fuller treatment to tourism and economic development impacts

  1. The market premium of the German Renewable Energy Sources Act 2012. Does it really contribute to both market and system integration of renewables?; Die Marktpraemie im EEG 2012. Ein sinnvoller Beitrag zur Markt- und Systemintegration erneuerbarer Energien?

    Energy Technology Data Exchange (ETDEWEB)

    Gawel, Erik [Helmholtz-Zentrum fuer Umweltforschung, Leipzig (Germany). Dept. Oekonomie; Univ. Leipzig (Germany). Inst. fuer Infrastruktur und Ressourcenmanagement; Purkus, Alexandra [Helmholtz-Zentrum fuer Umweltforschung (Germany). Dept. Bioenergie

    2013-03-15

    With the share of renewable energies within the electricity sector rising, improving their market integration (i.e. inclusion in the steering and remuneration processes of the electricity market) and system integration (i.e. enhanced responsibility for grid stability) is of increasing importance. To transform the energy system efficiently while ensuring security of supply, it is necessary to increase the alignment of renewable electricity production with short- and long-term market signals. The German Renewable Energy Sources Act 2012 introduced the market premium to provide market experience to renewable plant operators and incentives for demand-oriented electricity production. Shortly after its introduction, the instrument is already being criticised as ineffective and expensive. Building on early experiences, this article examines whether the market premium in its current design improves market and/or system integration, and if it seems suitable in principle to contribute to these aims (effectiveness). Also, potential efficiency gains and additional costs of ''administering integration'' are discussed (efficiency). While market integration in a strict sense (i.e. exposing renewables to price risks) is not the purpose of the market premium, it has successfully increased participation in direct marketing. However, windfall profits are high, and the benefits of gradually leading plant operators towards the market are questionable. Incentives for demand-oriented electricity production are established, but they prove insufficient particularly in the case of intermittent renewable energy sources. A continuation of the instrument in its current form therefore does not seem recommendable. To conclude, potential alternative solutions are presented.

  2. Partnerships for technology introduction -- Putting the technologies of tomorrow into the marketplace of today. Report to Congress on Sections 127 and 128 of the Energy Policy Act of 1992

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    This report to Congress was prepared on behalf of the Secretary of the US Department of Energy (DOE) in response to Sections 127 and 128 of the Energy Policy Act of 1992 (EPAct), Pub. L. 102-486. In preparing the report to the Congress, DOE has assessed the national and regional energy savings potential of products already on the market and those that will be available to consumers by the late 1990s. The Department has also examined the present cost-effectiveness of these emerging appliances as mature technologies. To help in its assessment, DOE organized eight workshops at which representatives from manufacturing and building industries, utilities, retailers and wholesalers, public interest groups and Federal and state government agencies could express their views. The information derived from these workshops was key to the formulation of the report`s general and specific recommendations. DOE has concluded that the Federal Government can effectively stimulate the market for emerging technologies by forming partnerships with the appliance industry and other interested parties promoting the use of highly efficient appliances. Based on the interaction with industry at the eight workshops and through direct contact, DOE has concluded that Federal action and technical assistance is not only desired by industry, but crucial to the expansion of these markets. Section 128 of EPAct requires an assessment of the energy savings and environmental benefits of replacing older, less efficient appliances with more efficient products than currently required by Federal law. Since early replacement of appliances is but one possible market-stimulating action, DOE has elected to include its discussion as part of the overall report to the Congress.

  3. Act No 282 reorganising ENEA

    International Nuclear Information System (INIS)

    1991-01-01

    This Act reorganises the National Agency for Research and Development of Nuclear and Alternative Energies - ENEA - and reorients its responsibilities. It is now called the National Agency for New Technologies, Energy and the Environment and retains its acronym (Ente per le nouve tecnologies, l'energia e l'ambiente - ENEA). It will also deal with environmental questions and new technologies, in particular, carrying out studies and research on the latter and evaluating their economic, social and environmental consequences. Already in 1982, the National Nuclear Energy Committee (CNEN) had been entrusted with wider tasks and renamed ENEA. The present ENEA retains its competence regarding nuclear activities, notably in the field of nuclear safety and radiation protection. The new Act confirms the tasks already conferred on the Nuclear Safety and Health Protection Directorate (DISP), we well as its operational independence while remaining within ENEA [fr

  4. Oxygen sensors and energy sensors act synergistically to achieve a graded alteration in gene expression: consequences for assessing the level of neuroprotection in response to stressors.

    Science.gov (United States)

    Renshaw, Gillian M C; Warburton, Joshua; Girjes, Adeeb

    2004-01-01

    Changes in gene expression are associated with switching to an autoprotected phenotype in response to environmental and physiological stress. Ubiquitous molecular chaperones from the heat shock protein (HSP) superfamily confer neuronal protection that can be blocked by antibodies. Recent research has focused on the interactions between the molecular sensors that affect the increased expression of neuroprotective HSPs above constitutive levels. An examination of the conditions under which the expression of heat shock protein 70 (Hsp70) was up regulated in a hypoxia and anoxia tolerant tropical species, the epaulette shark (Hemiscyllium ocellatum), revealed that up-regulation was dependent on exceeding a stimulus threshold for an oxidative stressor. While hypoxic-preconditioning confers neuroprotective changes, there was no increase in the level of Hsp70 indicating that its increased expression was not associated with achieving a neuroprotected state in response to hypoxia in the epaulette shark. Conversely, there was a significant increase in Hsp70 in response to anoxic-preconditioning, highlighting the presence of a stimulus threshold barrier and raising the possibility that, in this species, Hsp70 contributes to the neuroprotective response to extreme crises, such as oxidative stress. Interestingly, there was a synergistic effect of coincident stressors on Hsp70 expression, which was revealed when metabolic stress was superimposed upon oxidative stress. Brain energy charge was significantly lower when adenosine receptor blockade, provided by treatment with aminophylline, was present prior to the final anoxic episode, under these circumstances, the level of Hsp70 induced was significantly higher than in the pair-matched saline treated controls. An understanding of the molecular and metabolic basis for neuroprotective switches, which result in an up-regulation of neuroprotective Hsp70 expression in the brain, is needed so that intervention strategies can be devised

  5. Review of the nuclear liability act

    International Nuclear Information System (INIS)

    1990-01-01

    There has always been concern that nuclear materials have the potential to cause injury and property damage. For this reason, nuclear operators have always been required by national regulatory authorities to exercise special precautions in the operation of their facilities. Federal legislation was drafted in Canada as the Nuclear Liability Act in 1970. The Act ensures that funds are available from all operators of nuclear facilities to provide financial compensation to third parties for injuries or damages suffered as a result of a nuclear incident; at the same time the Act provides protection to the operators by limiting their related liability. The Act also protects persons other than operators. The review of the Act has progressed in stages. The first stage was conducted by the staff of the Atomic Energy Control Board and catalogued previously identified difficulties with the Act. The second stage was a preliminary examination of the Act by an Interdepartmental Working Group. 2 figs

  6. HASP: human acts simulation program

    International Nuclear Information System (INIS)

    Asai, Kiyoshi; Kambayashi, Shaw; Higuchi, Kenji; Kume, Etsuo; Otani, Takayuki; Fujii, Minoru; Uenaka, Junji; Fujisaki, Masahide.

    1990-01-01

    The Human Acts Simulation Program (HASP) aims computer simulations of mechanized human acts in a nuclear plant by a human shaped intelligent robot. The HASP has started as a ten-year program at Japan Atomic Energy Research Institute since 1987. The purposes of HASP are threefold as follows; development of basic and generalized design technologies for intelligent robots, development of basic technologies for an advanced intelligent and automatic nuclear power plant, and provision of artificial intelligence techniques for researchers in the nuclear field. In this paper, the contents of the HASP are described. (author)

  7. Directive of the Secretary of State for Social Affairs and Public Health and other Ministers of 24 November 1969, no. 132695, Stcrt. 239 concerning the implementation of Section 58, paragraphs 1 and 3 of the Nuclear Energy Act (Supervision of Observance)

    International Nuclear Information System (INIS)

    1969-01-01

    The Nuclear Energy Act lays down provisions relating to officials appointed by the Ministers concerned for the purpose of supervising observance of the Act. This Directive designates the Government Departments, the officials of which shall be responsible for ensuring compliance with the provisions governing the activities within their competence and provides for the setting up of a consultative and co-ordinating committee, which includes representatives of the Ministries concerned for co-operation between the different supervisory services. (NEA) [fr

  8. H.R. 3653: a bill to amend the Price-Anderson provisions of the Atomic Energy Act of 1954 to extend and improve procedures for liability and indemnification for nuclear incidents. Introduced in the House of Representatives, Ninety-Ninth Congress, Second Session, October 30, 1985

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    The Price-Anderson Amendments Act of 1986 amends provisions of the Atomic Energy Act of 1954 in order to improve the liability and indemnification procedures for nuclear incidents. The bill places the primary financial responsibility for protection on large electrical generating facilities, with a limit of $200 million. The bill also makes changes in premium, borrowing authority, and indemnification agreements for licensing. Other changes include defense waivers and judicial reviews

  9. S. 1439: Export Reorganization Act of 1976. Hearings before the Joint Committee on Atomic Energy, Congress of the United States, Ninety-Fourth Congress, Second Session on S. 1439, S. 3770, and H.R. 15273

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    The hearing of July 28, 1976 on S. 1439, a bill to reorganize certain export functions of the Federal government, included statements from the following: Sen. John O. Pastore, Chairman, JCAE; Sen. Abraham Ribicoff; Sen. Charles H. Percy; Myron B. Kratzer, Deputy Ass't. Secy. for Nuclear Energy and Energy Technology, Dept. of State; Charles W. Robinson, Deputy Secy. of State; Dr. Robert W. Fri, Deputy Administrator, ERDA; Marcus A. Rowden, Chairman, NRC, accompanied by Commissioners Kennedy and Gilinsky; and the joint prepared statement of Senators Glenn, Percy, and Ribicoff. S. 1439 was unanimously rejected by the Joint Committee in open meeting on Aug. 26, 1976. Then on Aug. 31, 1976, the Joint Committee met to receive testimony on the Nuclear Explosive Proliferation Control Act of 1976, S. 3770 and H.R. 15273, the proposed substitute for S. 1439. The Aug. 31 hearing included statements by Rep. Melvin Price, Vice Chairman, JCAE, and Fri, Rowden, and Kratzer. Further background information, mainly letters, is included under ''Additional Materials'' and in three appendixes

  10. Atomic Act amended

    International Nuclear Information System (INIS)

    Drabova, D.

    2002-01-01

    In the paper by the chairwoman of the Czech nuclear regulatory authority, the history of Czech nuclear legislation is outlined, the reasons for the amendment of the Atomic Act (Act No. 18/1997) are explained, and the amendments themselves are highlighted. The Act No. 13/2002 of 18 December 2001 is reproduced from the official Collection of Acts of the Czech Republic in the facsimile form. The following acts were thereby amended: Atomic Act No. 18/1997, Metrology Act No. 505/1990, Public Health Protection Act No. 258/2000, and Act No. 2/1969 on the Establishment of Ministries and Other Governmental Agencies of the Czech Republic. (P.A.)

  11. New Statute of the Nuclear Energy Research Centre (CEN), copy of Act No. 1429, amended by Act No. 1145 and Act No. 5652, respectively published in the annexes of the Belgian Official Gazette of 28 March 1963, 3 March 1966 and 17 September 1970

    International Nuclear Information System (INIS)

    1963-01-01

    The Statute of the Belgian Nuclear Research Centre (CEN) lays down the objects of the Centre which consist of undertaking research on the applications of nuclear energy, promoting scientific and technical studies of such applications, carrying out advanced technological research on other topics in the country's scientific and technological programmes; and at the public authorities' request co-ordinating such research by all means available to it. The CEN is run by a Board of Directors selected by representatives of the nuclear industry, scientific and university circles as well as by the Government. The Statute also provides for the rules of procedure of the Board as well as for the Centre's budget and management under the responsibility of a Director General appointed by the Board. Finally, the CEN is declared as being an establishment created in the public interest, and any amendment to its Statute must obtain the prior approval of the King. (NEA) [fr

  12. Review of the nuclear liability act

    International Nuclear Information System (INIS)

    1991-11-01

    The review of the Act has progressed in stages. The first stage was conducted by the staff of the Atomic Energy Control Board (AECB) and catalogued previously identified difficulties with the Act. The second stage was a preliminary examination of the Act by an Interdepartmental Working Group (IWG). The IWG was formed in 1982 at the direction of the President of the AECB. It was instructed to review all matters relating to the administration of, and experience with, the Act and to examine these matters in as much detail as was required to resolve each point raised during the review. The IWG was composed of representatives of the AECB (which administers the Act), the Department of Energy, Mines and Resources, the Department of Finance, the Department of Insurance, the Department of Justice, and the Treasury Board Secretariat

  13. 1984 Act on nuclear activities (1984:3)

    International Nuclear Information System (INIS)

    1984-01-01

    This 1984 Act on Nuclear Activities (1984:3) replaces the 1956 Atomic Energy Act as well as the 1977 Act on special permits to charge nuclear reactors with nuclear fuel and the 1980 Act on Public Insight into the Safety Work at Nuclear Power Plants. Like the 1956 Act, the 1984 Act in a safety legislation, which is based on a system of licensing conditions and supervision. According to the fundamental provisions of the 1984 Act, nuclear activities should be conducted in such a way as to meet safety requirements and fulfil the obligations that follow from Sweden's international agreements for the purpose of preventing the proliferation of nuclear weapons. (NEA) [fr

  14. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Therapeutics Lab Developing New Treatments The CF Foundation offers a number of resources for learning about clinical ... her father: Demonstrate and discuss common ACT therapies Offer their tips for fitting ACTs into daily life ...

  15. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Treatments and Therapies Airway Clearance Airway Clearance Techniques (ACTs) There are different ways to clear your airways. ... or caregiver. Older kids and adults can choose ACTs that they can do on their own. Share ...

  16. Energies; Energies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    In the framework of the National Debate on the energies in a context of a sustainable development some associations for the environment organized a debate on the nuclear interest facing the renewable energies. The first part presents the nuclear energy as a possible solution to fight against the greenhouse effect and the associated problem of the wastes management. The second part gives information on the solar energy and the possibilities of heat and electric power production. A presentation of the FEE (French wind power association) on the situation and the development of the wind power in France, is also provided. (A.L.B.)

  17. German legislation for promotion of renewable energies 2014. Act on feed-in and guaranteed pricing of electricity from renewable energy sources (EEG). Commentary. 7. new rev. ed.; Erneuerbare-Energien-Gesetz 2014. Gesetz fuer den Ausbau erneuerbarer Energien. Kommentar

    Energy Technology Data Exchange (ETDEWEB)

    Salje, Peter [Hannover Univ. (Germany). Lehrstuhl fuer Zivilrecht und Recht der Wirtschaft

    2015-07-01

    The EEG is continuously subjected to changes and the permanent center of political discussions. Therefore now already the 7th edition of the EEG comment of the science and practice well recognized and highly recognized author Prof. Dr. Dr. Peter Salje appear. The revision includes, inter alia, further evaluation of the law of electric power produced from renewable energy sources from the EEG of 2012 and the regulations made there under (including Biomass and AusglMechV). The changes associated with the so-called Photovoltaic amendment dated August 2012 and the recent case law since the publication of the previous edition handed down are considered. In particular, the incorporation of the full basic EEG reform in 2014 guarantees the highest topicality. [German] Das EEG ist fortlaufend Neuerungen unterworfen und im staendigen Mittelpunkt der politischen Diskussionen. In nunmehr bereits 7. Auflage erscheint daher der EEG-Kommentar von dem in Wissenschaft und Praxis bestens ausgewiesenen und hoechst anerkannten Autor Prof. Dr. Dr. Peter Salje. Die Neubearbeitung umfasst u.a. die weitere Auswertung des Rechts der Stromerzeugung aus Erneuerbaren Energien aus dem EEG 2012 und den dazu ergangenen Verordnungen (u.a. BiomasseV und AusglMechV). Die mit der sog. Photovoltaik-Novelle vom August 2012 einhergehenden Aenderungen sowie die seit Erscheinen der Vorauflage ergangene Rechtsprechung werden beruecksichtigt. Insbesondere die vollumfaengliche Einarbeitung der grundlegenden EEG-Reform 2014 garantiert hoechste Aktualitaet.

  18. Nuclear Installations Act 1965

    International Nuclear Information System (INIS)

    1965-01-01

    This Act governs all activities related to nuclear installations in the United Kingdom. It provides for the licensing procedure for nuclear installations, the duties of licensees, the competent authorities and carriers of nuclear material in respect of nuclear occurrences, as well as for the system of third party liability and compensation for nuclear damage. The Act repeals the Nuclear Installations (Licensing and Insurance) Act 1959 and the Nuclear Installations (Amendment Act) 1965 except for its Section 17(2). (NEA) [fr

  19. The history of energy industry law in Germany. With particular emphasis on the development of the Energy Act (EnWG) and current proposals for reform under discussion; Zur Entwicklung des Energierechts in Deutschland. Unter besonderer Beruecksichtigung des Energiewirtschaftsgesetzes und der aktuellen Reformdiskussion

    Energy Technology Data Exchange (ETDEWEB)

    Smeddinck, U.

    1995-11-01

    The paper describes the history and development of the regulatory framework governing the energy industry and the reasons why this legislation has been creating an organisational framework of the power industry in Germany with some strikingly peculiar features. The core structure and the essential aspects of the Energy Act (EnWG) are discussed in detail, followed by a survey of relevant cartel laws and the regime of franchise agreements and franchise duties. The amendments made in response to the oil crisis in the early seventies are mentioned, and current trends and proposals for reform are outlined. The Annex contains material illustrating a number of significant developments and issues in the history of the energy industry law, with brief explanations. The bibliography also lists publications of interest to readers wishing to get more insight into ongoing debates about problems posed by energy industry law, and proposed reforms. [Deutsch] Der Beitrag zeichnet die Entstehung und Veraenderung des rechtlichen Ordnungsrahmens nach, der fuer die derzeitige eigentuemliche Organisation der deutschen Elektrizitaetswirtschaft verantwortlich ist. Im Mittelpunkt steht das EnWG mit seinem Grundmuster. Darueberhinaus werden die einschlaegigen kartellrechtlichen Vorschriften und das Konzessionsabgabenrecht vorgestellt. Weiter wird die Reaktion des Gesetzgebers auf die dramatische Oelkrise zu Beginn der siebziger Jahre deutlich. Schliesslich wird der gegenwaertige Stand der Novellierungsbemuehungen skizziert. Die im Anhang enthaltenen Materialien veranschaulichen einige markante Punkte der energierechtlichen Entwicklung. Sie sind jeweils mit einer kurzen Erlaeuterung versehen. Das Literaturverzeichnis enthaelt auch Veroeffentlichungen zur aktuellen Diskussion, die dem interessierten Leser den vertieften Einstieg in dieses Problemfeld moeglich machen.

  20. S.2166: An act to reduce the Nation's dependence on imported oil, to provide for the energy security of the Nation, and for other purposes, introduced in the United States Senate and House of Representatives, One Hundred Second Congress, Second Session, February 19, 1992

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    This bill, also referred to as the National Energy Security Act of 1992, contains the following: Title I - Findings and purposes: Climate protection goals,least-cost energy strategy, and Director of climate protection: Title II - Definitions; Title III (none); Title IV - Fleets and alternative fuels: Alternative fuel fleets, Alternative fuels, Mass transit and training; Title V - Renewable energy: CORECT and COEECT, Renewable energy initiatives, Hydropower; Title VI - Energy efficiency: Industrial, commercial, and residential, Federal energy management, Utilities, State, local, insular, and tribal energy assistance, LIHEAP options pilot program, Consultative commission on western hemisphere energy and environment; Title VII (none); Title VIII - Advanced nuclear reactor commercialization; Title IX - Nuclear reactor licensing; Title X - Uranium: Uranium enrichment, Uranium; Title XI - Natural gas; Title XII - Outer continental shelf: Coastal communities impact assistance, Coastal resources enhancement fund, relationship to other law, Prohibition of leasing and preleasing activity; Title XIII - Research, development, demonstration and commercialization activities; Title XIV - Coal and coal technology, Electricity, Innovative technology transfer; Title XV - Public Utility Holding Company Act reform; Title XVI - Strategic Petroleum Reserve; Title XVII - Stratospheric ozone depletion; Title XVIII - Indian energy resource development commission; Title XIX - General provisions

  1. Act of 20 July 1978 establishing provisions enabling the International Atomic Energy Agency to undertake inspections and verifications on the Belgian territory in execution of the International Agreement of 5 April 1973 made in implementation of paragraph 1 and 4 of Article III of the Treaty of 1 July 1968 on the Non-Proliferation of Nuclear Weapons

    International Nuclear Information System (INIS)

    1978-01-01

    The purpose of this Act is to authorise representatives of the International Atomic Energy Agency to carry out inspections and verifications in installations in Belgium where source materials and special fissionable materials are produced, stored or used. These inspections are organised in the frame of the Agreement on verification of safeguards concluded between that Agency and Euratom. (NEA) [fr

  2. Directive of the Secretary of State for Social Affairs and Public Health of 18 December 1969, no. 133.024, Stcrt. 253, concerning the Nomination of Civil Servants in Implementation of Section 58, paragraphs 1 and 3 of the Nuclear Energy Act

    International Nuclear Information System (INIS)

    1969-01-01

    Further to the Directive of 29 November 1969 (Stcrt.239) on officials responsible for supervising observance of the provisions of the Nuclear Energy Act, this Directive concerns the appointment of medical and veterinary inspectors under the authority of the Government Public Health Inspectorate. (NEA) [fr

  3. Energies; Energies

    Energy Technology Data Exchange (ETDEWEB)

    Cotard, E.

    2002-02-01

    A review is made about the consequences of the European directive on energy that entered into application in august 2000. It appears that most countries are opening their electricity and gas markets at a faster pace than required by the E.U. directive. European gas imports reached 480 Gm{sup 3} in 2000 and are expected to be over 700 Gm{sup 3} in 2015, so the question of the reliability of the gas suppliers has to be answered at the European level. The current time is marked by an increase of the complexity of the energy market that is due to different factors: 1) the delay in the implementation of European energy directives in France, 2) new arrangement is occurring in United-Kingdom in the energy sector, 3) the lack of a regulating authority in Germany, and 4) the difficulty of inter-connecting the different European energy networks. This transitory period may generate some economic imbalances and competition disturbances by allowing some enterprises to benefit from lower energy prices before others. (A.C.)

  4. Learning dialog act processing

    OpenAIRE

    Wermter, Stefan; Löchel, Matthias

    1996-01-01

    In this paper we describe a new approach for learning dialog act processing. In this approach we integrate a symbolic semantic segmentation parser with a learning dialog act network. In order to support the unforeseeable errors and variations of spoken language we have concentrated on robust data-driven learning. This approach already compares favorably with the statistical average plausibility method, produces a segmentation and dialog act assignment for all utterances in a robust manner,...

  5. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Reform Could Impact People With CF The Preserving Employee Wellness Programs Act Our Advocacy Work Advocacy Achievements Advocacy News Briefings, Testimonies, and Regulatory ...

  6. Radiological Protection Act 1970

    International Nuclear Information System (INIS)

    1970-01-01

    This Act provides for the establishment of a Radiological Protection Board to undertake research and advise on protection from radiation hazards. Its functions include provision of advice to Government departments with responsibilities in relation to protection of sectors of the community or the community as a whole against the hazards of ionizing radiation. The Act, which lays down that the Board shall replace certain departments concerned with radiation protection, repeals several Sections of the Radioactive Substances Act 1948 and the Science and Technology Act 1965. (NEA) [fr

  7. 25 CFR 700.33 - Act (The Act).

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Act (The Act). 700.33 Section 700.33 Indians THE OFFICE OF NAVAJO AND HOPI INDIAN RELOCATION COMMISSION OPERATIONS AND RELOCATION PROCEDURES General Policies and Instructions Definitions § 700.33 Act (The Act). (a) The Act. The Act is Pub. L. 93-531, (88 Stat...

  8. Radioactive Material (Road Transport) Act 1991

    International Nuclear Information System (INIS)

    1991-01-01

    This Act came into force on 27 August 1991. It replaces earlier legislation dating from 1948 and enables the United Kingdom to give effect to the International Atomic Energy Agency's (IAEA) latest recommended Regulations for the Safe Transport of Radioactive Material. The new Act clarifies and extends the power of the Secretary of State to make regulations regarding, among other things, the design, labelling, handling, transport and delivery of packages containing radioactive material and the placarding of vehicles transporting such packages. The Act gives the Secretary of State the power to appoint inspectors to assist him in enforcing the regulations. (NEA)

  9. Marine Mammal Protection Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Marine Mammal Protection Act (MMPA or Act) prohibits, with certain exceptions, the "take" of marine mammals in U.S. waters and by U.S. citizens on the high seas,...

  10. Collective speech acts

    NARCIS (Netherlands)

    Meijers, A.W.M.; Tsohatzidis, S.L.

    2007-01-01

    From its early development in the 1960s, speech act theory always had an individualistic orientation. It focused exclusively on speech acts performed by individual agents. Paradigmatic examples are ‘I promise that p’, ‘I order that p’, and ‘I declare that p’. There is a single speaker and a single

  11. Americans with Disabilities Act.

    Science.gov (United States)

    Kaesberg, Mary Ann; Murray, Kenneth T.

    1994-01-01

    Presents a 35-item checklist of practical activities for school district compliance with the Americans with Disabilities Act (ADA). The checklist is based on ADA statutes, other civil rights legislation and litigation, as well as pertinent regulations and the legislative history of the act contained in the Congressional Record. (MLF)

  12. Radiation emitting devices act

    International Nuclear Information System (INIS)

    1970-01-01

    This Act, entitled the Radiation Emitting Devices Act, is concerned with the sale and importation of radiation emitting devices. Laws relating to the sale, lease or import, labelling, advertising, packaging, safety standards and inspection of these devices are listed as well as penalties for any person who is convicted of breaking these laws

  13. Nuclear Installations Act 1969

    International Nuclear Information System (INIS)

    1969-01-01

    The purpose of this Act is to amend the Nuclear Installations Act 1965 to bring it into full compliance with the international conventions on nuclear third party liability to which the United Kingdom is a Signatory, namely, the Paris Convention, the Brussels Supplementary Convention and the Vienna Convention. (NEA) [fr

  14. Decree of 28 December 1965, Stb. 647, in implementation of Section 2 of the Act of 27 October 1965, Stb 546, on Third Party Liability in the Field of Nuclear Energy

    International Nuclear Information System (INIS)

    1965-01-01

    This Decree excludes from the scope of application of the Nuclear Incidents (Third Party Liability) Act, small quantities of nuclear substances during transport in view of the small extent of the risk involved. (NEA) [fr

  15. Calendar Year 2007 Resource Conservation and Recovery Act Annual Monitoring Report for the U.S. Department of Energy Y-12 National Security Complex, Oak Ridge, Tennessee - RCRA Post-Closure Permit Nos. TNHW-113, TNHW-116, and TNHW-128

    Energy Technology Data Exchange (ETDEWEB)

    Elvado Environmental

    2008-02-01

    This report contains groundwater quality monitoring data obtained during calendar year (CY) 2007 at the following hazardous waste treatment, storage, and disposal (TSD) units located at the US Department of Energy (DOE) Y-12 National Security Complex (hereafter referenced as Y-12) in Oak Ridge, Tennessee; this S-3 Site, Oil Landfarm, Bear Creek Burial Grounds/Walk-In Pits (BCBG/WIP), Eastern S-3 Site Plume, Chestnut Ridge Security Pits (CRSP), Chestnut Ridge Sediment Disposal Baste (CRSDB), few Hollow Quarry (KHQ), and East Chestnut Ridge Waste Pile (ECRWP). Hit monitoring data were obtained in accordance with the applicable Resource Conservation and Recovery Act of 1976 (RCRA) hazardous waste post-closure permit (PCP). The Tennessee Department of Environment and Conservation (TDEC) - Division of Solid Waste Management issued the PCPs to define the requirements for RCRA post-closure inspection, maintenance, and groundwater monitoring at the specified TSD units located within the Bear Creek Hydrogeologic Regime (PCP no. TNHW-116), Upper East Fork Poplar Creek Hydrogeologic Regime (PCP no. TNHW-113), and Chestnut Ridge Hydrogeologic Regime (PCP no. TNHW-128). Each PCP requires the Submittal of an annual RCRA groundwater monitoring report containing the groundwater sampling information and analytical results obtained at each applicable TSD unit during the preceding CY, along with an evaluation of groundwater low rates and directions and the analytical results for specified RCRA groundwater target compounds; this report is the RCRA annual groundwater monitoring report for CY 2007. The RCRA post-closure groundwater monitoring requirements specified in the above-referenced PCP for the Chestnut Ridge Regime replace those defined in the previous PCP (permit no. TNHW-088), which expired on September 18, 2005, but remained effective until the TDEC issued the new PCP in September 2006. The new PCP defines site-specific groundwater sampling and analysis requirements for the

  16. The Radiation Protection Act

    International Nuclear Information System (INIS)

    Persson, L.

    1989-01-01

    The new Radiation Protection Act (1988:220) entered into force in Sweden on July 1st, 1988. This book presents the Act as well as certain regulations connected to it. As previously, the main responsibility for public radiation protection will rest with one central radiation protection authority. According to the 1988 Act, the general obligations with regard to radiation protection will place a greater responsibility than in the past on persons carrying out activities involving radiation. Under the act, it is possible to adjust the licensing and supervisory procedures to the level of danger of the radiation source and the need for adequate competence, etc. The Act recognises standardised approval procedures combined with technical regulations for areas where the risks are well known. The Act contains several rules providing for more effective supervision. The supervising authority may in particular decide on the necessary regulations and prohibitions for each individual case. The possibilities of using penal provisions have been extended and a rule on the mandatory execution of orders has been introduced. The Ordinance on Radiation Protection (1988:293) designates the National Institute of Radiation Protection (SSI) as the central authority referred to in the Radiation Protection Act. The book also gives a historic review of radiation protection laws in Sweden, lists regulations issued by SSI and presents explanations of radiation effects and international norms in the area. (author)

  17. 77 FR 64112 - Office of Energy Efficiency and Renewable Energy

    Science.gov (United States)

    2012-10-18

    ... DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy Nationwide Categorical Waivers of the American Recovery and Reinvestment Act AGENCY: Office of Energy Efficiency and Renewable... Efficiency and Renewable Energy, U.S. Department of Energy. [FR Doc. 2012-25636 Filed 10-17-12; 8:45 am...

  18. US Atomic Energy Law

    International Nuclear Information System (INIS)

    1981-01-01

    This is a new volume follows in the series supplementing the volumes 11 and 12 published in 1965 and 1966, updating the collection of Federal Acts and Executive Orders of the President of the United States of America relating to atomic energy legislation. Since the publication of volumes 11 and 12, the US Atomic Energy Act of 1954 alone has been amended 25 times, mainly as a consequence of by the Nuclear Non-Proliferation Act and the Uranium Mill Tailings Radiation Control Act, both of 1978. The Atomic Energy Act of 1954 is supplemented by a selection of the most important Federal Acts, Executive Orders of the President and Resolutions of the Congress. (orig./HSCH) [de

  19. 75 FR 63703 - Privacy Act of 1974; Privacy Act Regulation

    Science.gov (United States)

    2010-10-18

    ... FEDERAL RESERVE SYSTEM 12 CFR Part 261a [Docket No. R-1313] Privacy Act of 1974; Privacy Act... implementing the Privacy Act of 1974 (Privacy Act). The primary changes concern the waiver of copying fees... records under the Privacy Act; the amendment of special procedures for the release of medical records to...

  20. Abandoned Shipwreck Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data represents the extent of the Abandoned Shipwreck Act (ASA). The ASA allows states to manage a broad range of resources within submerged lands, including...

  1. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... The Preserving Employee Wellness Programs Act Our Advocacy Work Advocacy ... the value of tapping into the expertise that only people with CF and their families have. We invite you to share insights to ...

  2. ACTS – SUCCESS STORY

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. ACTS – SUCCESS STORY. Totally 103 experiments were conducted and the programme succeeded in the areas. Medicine; Education; Defence; Emergency Response; Maritime and Aeronautical Mobile Communications; Science and Astronomy.

  3. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... There are different ways to clear your airways. Most are easy to do. Infants and toddlers will ... best ACT is the one that you are most likely to perform as part of your daily ...

  4. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... to loosen mucus from airway walls. See how different airway clearance techniques work to help you clear the thick, sticky mucus ... Offer their tips for fitting ACTs into daily life Airway Clearance Techniques | Webcast ... Facebook Twitter ...

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    Medline Plus

    Full Text Available ... CF Community in Health Care Reform Milestones in Health Care Reform How Tax Reform Could Impact People With CF The Preserving Employee Wellness Programs Act Our Advocacy Work Advocacy Achievements ...

  6. Clean Water Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data represent geographic terms used within the Clean Water Act (CWA). The CWA establishes the basic structure for regulating the addition of pollutants...

  7. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... toddlers will need help from a parent or caregiver. Older kids and adults can choose ACTs that ... into the smaller airways to attack bacteria. Choose What's Best for You Your respiratory therapist or another ...

  8. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... that help thin and move the mucus, and antibiotics. Bronchodilators should be inhaled before you start ACTs. This medication helps to widen your airways (bronchi) by relaxing the ...

  9. Endangered Species Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of the Endangered Species Act (ESA) is to protect and recover imperiled species and the ecosystems upon which they depend. The U.S. Fish and Wildlife...

  10. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Reform Could Impact People With CF The Preserving Employee Wellness Programs Act Our Advocacy Work Advocacy Achievements ... on their own. Share Facebook Twitter Email More options Print Share Facebook Twitter Email Print Permalink All ...

  11. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... 3-D Structure Consortium CFTR Folding Consortium Epithelial Stem Cell Consortium Mucociliary Clearance Consortium SUCCESS WITH THERAPIES RESEARCH ... ACTs involve coughing or huffing . Many of them use percussion (clapping) or vibration to loosen mucus from ...

  12. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... today. ANNUAL FUND Become a Corporate Supporter Cause Marketing Make a Charitable Gift Our Corporate Supporters Workplace ... Clearance Airway Clearance Techniques (ACTs) There are different ways to clear your airways. Most are easy to ...

  13. Marine Pollution Prevention Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Marine Pollution Prevention Act of 2008 implements the International Convention for the Prevention of Pollution from Ships, including related Protocols (MARPOL)...

  14. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... CF Community in Health Care Reform Milestones in Health Care Reform How Tax Reform Could Impact People With CF The Preserving Employee Wellness Programs Act Our Advocacy Work Advocacy Achievements Advocacy News Briefings, Testimonies, and Regulatory ...

  15. Preventive Radiation Protection Act

    International Nuclear Information System (INIS)

    Roewer, H.

    1988-01-01

    The commentary is intended to contribute to protection of the population by a practice-oriented discussion and explanation of questions arising in connection with the Preventive Radiation Protection Act. Leaving aside discussions about abandonment of nuclear power, or criticism from any legal point of view, the commentary adopts the practical approach that accepts, and tries to help implementing, the act as it is. It is a guide for readers who are not experts in the law and gives a line of orientation by means of explanations and sometimes by citations from other acts (in footnotes). The commentary also presents the EURATOM Directive No. 3954/87 dated 22 December 1987, the EC Directive No. 3955/87 dated 22 December 1987, and the EC Directive No. 1983/88 dated 5 July 1988. A tabular survey shows the system of duties and competences defined by the Preventive Radiation Protection Act. (RST) [de

  16. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Contraception and Protection How Does CF Affect the Female Reproductive System? How Does CF Affect the Male ... Reform Could Impact People With CF The Preserving Employee Wellness Programs Act Our Advocacy Work Advocacy Achievements ...

  17. ACT250 Districts

    Data.gov (United States)

    Vermont Center for Geographic Information — The ACT 250 Districts layer is part of a larger dataset that contains administrative boundaries for Vermont's Agency of Natural Resources. The dataset includes...

  18. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... ACTs involve coughing or huffing . Many of them use percussion (clapping) or vibration to loosen mucus from airway walls. See how different airway clearance techniques work to help you clear the thick, sticky mucus ...

  19. Acts of Research

    DEFF Research Database (Denmark)

    Nelund, Sidsel

    place mostly in seminars and articles, in which knowledge is often discussed as an intrinsic quality of the artwork. Acts of Research, however, is devoted to studying the rise of knowledge production in contemporary art from the perspective of artistic, curatorial and educational research...... described as knowledge producers and exhibitions and art works as instances of knowledge production. Acts of Research: Knowledge Production in Contemporary Arts between Knowledge Economy and Critical Practices analyses this development. The academic discussion of knowledge production in the arts has taken...... with an awareness of larger political, economic, geographical and art-related aspects. The concept of ‘acts of research’ is suggested as a way to understand knowledge production as a creative act in which research carried out in relation to a specific material challenges and resists the protocols of conventional...

  20. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Congressional Cystic Fibrosis Caucus Our Policy Agenda Policy Principles SIGN UP FOR ADVOCACY ACTION ALERTS Community We ... options Print Share Facebook Twitter Email Print Permalink All ACTs involve coughing or huffing . Many of them ...

  1. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... How Does CF Affect the Male Reproductive System? Sex and CF: Some Practical Advice Family Planning and ... need help from a parent or caregiver. Older kids and adults can choose ACTs that they can ...

  2. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... FOR ADVOCACY ACTION ALERTS Community We recognize the value of tapping into the expertise that only people ... ACTs involve coughing or huffing . Many of them use percussion (clapping) or vibration to loosen mucus from ...

  3. National Environmental Policy Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Environmental Policy Act (NEPA) was the first major environmental law in the United States and established national environmental policies for the...

  4. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Reform Could Impact People With CF The Preserving Employee Wellness Programs Act Our Advocacy Work Advocacy Achievements ... Board of Trustees Our Leadership Careers Reports and Financials Contact Us Governance and Policies What is CF? ...

  5. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... own. Share Facebook Twitter Email More options Print Share Facebook Twitter Email Print Permalink All ACTs involve ... CF Care Team Research About Our Research Developing New Treatments Researcher Resources Assistance Services Find Resources: CF ...

  6. Affordable Care Act (ACA)

    Data.gov (United States)

    Social Security Administration — The Affordable Care Act (ACA) is a federal statute enacted with a goal of increasing the quality and affordability of health insurance. Through a web service, CMS...

  7. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... The Preserving Employee Wellness Programs Act Our Advocacy Work Advocacy Achievements Advocacy News Briefings, Testimonies, and Regulatory Comments Congressional Cystic Fibrosis Caucus Our Policy Agenda Policy Principles SIGN UP FOR ADVOCACY ACTION ...

  8. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... people with cystic fibrosis so that they make smart decisions about CF-related research, treatment, and access ... The Preserving Employee Wellness Programs Act Our Advocacy Work Advocacy Achievements Advocacy News Briefings, Testimonies, and Regulatory ...

  9. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... What to Consider Regarding a Lung Transplant Medications Antibiotics Bronchodilators CFTR Modulator Therapies Mucus Thinners Nebulizer Care ... that help thin and move the mucus, and antibiotics. Bronchodilators should be inhaled before you start ACTs. ...

  10. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... resources you need to continuously build upon this work. Awards and Grants Career Development Awards Research Awards ... The Preserving Employee Wellness Programs Act Our Advocacy Work Advocacy Achievements Advocacy News Briefings, Testimonies, and Regulatory ...

  11. The Corporations Act 2001

    OpenAIRE

    Bostock, Tom

    2002-01-01

    The author outlines reforms made in Australia in the area of company law with an analysis of the Corporations Act 2001, which along with the Australian Securities and Investments Commission Act 2001 comprises Corporations legislation in Australia. Article by Tom Bostock (a partner in the law firm Mallesons Stephen Jaques, Melbourne, Australia). Published in Amicus Curiae - Journal of the Institute of Advanced Legal Studies and its Society for Advanced Legal Studies. The Journal is produced by...

  12. Dissection of autophagy in tobacco BY-2 cells under sucrose starvation conditions using the vacuolar H(+)-ATPase inhibitor concanamycin A and the autophagy-related protein Atg8.

    Science.gov (United States)

    Yano, Kanako; Yanagisawa, Takahiro; Mukae, Kyosuke; Niwa, Yasuo; Inoue, Yuko; Moriyasu, Yuji

    2015-01-01

    Tobacco BY-2 cells undergo autophagy in sucrose-free culture medium, which is the process mostly responsible for intracellular protein degradation under these conditions. Autophagy was inhibited by the vacuolar H(+)-ATPase inhibitors concanamycin A and bafilomycin A1, which caused the accumulation of autophagic bodies in the central vacuoles. Such accumulation did not occur in the presence of the autophagy inhibitor 3-methyladenine, and concanamycin in turn inhibited the accumulation of autolysosomes in the presence of the cysteine protease inhibitor E-64c. Electron microscopy revealed not only that the autophagic bodies were accumulated in the central vacuole, but also that autophagosome-like structures were more frequently observed in the cytoplasm in treatments with concanamycin, suggesting that concanamycin affects the morphology of autophagosomes in addition to raising the pH of the central vacuole. Using BY-2 cells that constitutively express a fusion protein of autophagosome marker protein Atg8 and green fluorescent protein (GFP), we observed the appearance of autophagosomes by fluorescence microscopy, which is a reliable morphological marker of autophagy, and the processing of the fusion protein to GFP, which is a biochemical marker of autophagy. Together, these results suggest the involvement of vacuole type H(+)-ATPase in the maturation step of autophagosomes to autolysosomes in the autophagic process of BY-2 cells. The accumulation of autophagic bodies in the central vacuole by concanamycin is a marker of the occurrence of autophagy; however, it does not necessarily mean that the central vacuole is the site of cytoplasm degradation.

  13. The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib.

    Science.gov (United States)

    Booth, Laurence; Roberts, Jane L; Poklepovic, Andrew; Kirkwood, John; Sander, Cindy; Avogadri-Connors, Francesca; Cutler, Richard E; Lalani, Alshad S; Dent, Paul

    2018-02-01

    The FDA approved irreversible inhibitor of ERBB1/2/4, neratinib, was recently shown to rapidly down-regulate the expression of ERBB1/2/4 as well as the levels of c-MET and mutant K-RAS via autophagic degradation. In the present studies, in a dose-dependent fashion, neratinib reduced the expression levels of mutant K-RAS or of mutant N-RAS, which was augmented in an additive to greater than additive fashion by the HDAC inhibitors sodium valproate and AR42. Neratinib could reduce PDGFRα levels in GBM cells, that was enhanced by sodium valproate. Knock down of Beclin1 or of ATG5 prevented neratinib and neratinib combined with sodium valproate / AR42 from reducing the expression of mutant N-RAS in established PDX and fresh PDX models of ovarian cancer and melanoma, respectively. Neratinib and the drug combinations caused the co-localization of mutant RAS proteins and ERBB2 with Beclin1 and cathepsin B. The drug combination activated the AMP-dependent protein kinase that was causal in enhancing HMG Co A reductase phosphorylation. Collectively, our data reinforce the concept that the irreversible ERBB1/2/4 inhibitor neratinib has the potential for use in the treatment of tumors expressing mutant RAS proteins.

  14. Nuclear Safeguards and Electricity (Finance) Act 1978

    International Nuclear Information System (INIS)

    1978-01-01

    This Act of 30 June 1978 gives effect to the Agreement concluded on 6 September 1976 between the United Kingdom, the European Atomic Energy Community and the International Atomic Energy Agency for the application of safeguards in the territory of the United Kingdom in connection with the Treaty on the Non-Proliferation of nuclear Weapons. It also deals with the financial support provided by the State for the generating station at Drax. (NEA) [fr

  15. Informal administrative acts in public economic law

    International Nuclear Information System (INIS)

    Bauer, H.

    1987-01-01

    The article deals with agreements between the administration and citizens, which play a considerable part in public commercial law and in atomic energy law. The legal basis can be the doctrine of administrative legal relationship, which clarifies the reciprocity and multilaterality of the legal relationship. In the future informal administrative acts will have an increasing meaning. (CW) [de

  16. Act local, think global

    International Nuclear Information System (INIS)

    Lewis, Chris; McRoberts, Doug

    2002-01-01

    Tip O'Neill, one of the grand old men of modem US politics, once famously remarked that all politics is local. Like most politicians who succeed on the national stage - and not just in the US - it was a truth he never lost sight of. What is true for politicians is equally true in the communications business. We may increasingly live in a global village, but successful companies - even multi-nationals - forget the importance of local and regional public relations at their peril. Think of Douglas Ivester, the CEO of Coca-Cola at the time of the 1999 Belgian contamination scandal, who allegedly reacted to first reports of the crisis by asking: 'Where the hell is Belgium?' A more appropriate question today - several years after Coke's share price toppled and the CEO was unceremoniously sacked - might be: 'Who the hell is Douglas Nester?' But - to adapt another famous phrase - the fact that communications (and marketing) professionals still need to 'act local' as much as ever before should not blind us to the growing need to 'think global'. In the nuclear industry, as in the world economy generally, increasing global integration is a reality, as are the international nature of the news media and the increasingly global nature of the anti-nuclear pressure groups. Indeed, it was the growing need for a truly global information network to counter these trends, by increasing the overall speed and accuracy of the worldwide nuclear information flow, that led the nuclear community to establish NucNet in 1991. So where exactly is the line between local and regional nuclear communications on the one hand, and global communications on the other? Is there one spin for a regional audience, and another for a global audience? This presentation proposes some guiding principles, by examining the response of nuclear communicators world-wide to the new communications agenda imposed in the wake of the September 11th suicide attacks in the US. NucNet President Doug McRoberts and Executive

  17. Outer Continental Shelf Lands Act

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data represents geographic terms used within the Outer Continental Shelf Lands Act (OCSLA or Act). The Act defines the United States outer continental shelf...

  18. Act No. 442 of 13 June 1979 containing rules with regard to a number of general subjects concerning the environment (Environment Act - general provisions)

    International Nuclear Information System (INIS)

    1979-08-01

    This Act and the Act implementing it (Bulletin of Acts, Orders and Decrees No. 443, 1979) came into foce on 1st September 1980. The Environmental Protection Act makes a number of amendments to the Nuclear Energy Act of 21st February 1963. The amendments concern the licensing procedures, in particular, applications, issue of licences and appeals and provide for greater access to documents as well as public involvement in the granting of licences. (NEA) [fr

  19. 18 CFR 380.13 - Compliance with the Endangered Species Act.

    Science.gov (United States)

    2010-04-01

    ... Endangered Species Act. 380.13 Section 380.13 Conservation of Power and Water Resources FEDERAL ENERGY... ENVIRONMENTAL POLICY ACT § 380.13 Compliance with the Endangered Species Act. (a) Definitions. For purposes of... Species Act of 1973, as amended (ESA). (2) Consultation requirement. (i) Prior to the filing of the...

  20. Report and accounts of the United Kingdom Atomic Energy Authority for the year ended 31 March 1981 together with the Comptroller and Auditor General's report on the accounts submitted to the Secretary of State for Energy in accordance with the Atomic Energy Authority Act 1954

    International Nuclear Information System (INIS)

    1981-01-01

    The report falls under the headings: general (nuclear power development; safety and the environment; fusion; underlying research; Select Committee on Energy; work outside the nuclear power programme; members, organisation and staff; energy conservation; information services; finance); technical (advanced gas-cooled reactor; water-cooled reactors; fast reactor; safety and the environment; nuclear contract work; nuclear fusion; underlying research; work outside the nuclear power programme); appendices (Authority senior staff; functions of Authority establishments; Authority reactors and major facilities); accounts. (U.K.)