WorldWideScience

Sample records for ene palo liina-mai

  1. Ene Ammer / Ene Ammer

    Index Scriptorium Estoniae

    Ammer, Ene

    1998-01-01

    ARS-i disainer Ene Ammer õppimisest Tartu kunstikoolis, ERKI-s. Esimestest töödest ARS-is, esimestest näitusekujundustest (elektroonika-alane autorong rändnäitus Moskva tellimisel), personaalnäituste ja messide kujundustest, suurnäituste komplekskujundusest, Olümpianäitusest, viimastest suurnäitustest pikemalt 1988. a. korraldatud Baltikumi ühisnäitusest "Kõik laste heaks" kujundusest. Sisearhitekt Mait Summatavet Ene Ammerist

  2. Palo : Integratsija - protsess dvustoronnii / Urve Palo

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2007-01-01

    Rahvastikuminister Urve Palo vastab on-line intervjuus küsimustele, mis puudutavad Eesti kodakondsuse andmist, tema hinnangut eelmise rahvastikuministri Paul-Eerik Rummo tegevusele, aprillikuiste sündmuste põhjusi, venekeelse telekanali loomist, venekeelsete koolide üleminekut osalisele eestikeelsele õppele, venelaste kultuurautonoomiat, etniliste eestlaste tagasipöördumist Venemaalt. Lisa: Urve Palo

  3. Pishi pro Palo / Urve Palo ; interv. Jevgenija Garanzha

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2008-01-01

    Rahvastikuminister Urve Palo tegutseb põhimõtte järgi - kui on probleemid, leiduvad neile ka lahendused. Uuest integratsiooniprogrammist, kodakondsusest, vene valijaskonnast, keeleoskusest, kultuurautonoomiast

  4. Anname lasteaiale lisaraha / Urve Palo

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2007-01-01

    Sotsiaalminister Urve Palo tutvustab järgmisel aastal käivituvat riiklikku programmi "Igale lapsele lasteaiakoht", kuid ainult riigi rahaga ei suudeta tagada lasteaiakohti kõigile soovijatele, aitama peavad ka kohalikud omavalitsused

  5. Ene Ergma / Ene Ergma ; interv. Anneli Ammas

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2007-01-01

    Eesti Vabariigi Riigikogu esimees 2003-2006 Ene Ergma oma lapsepõlvest ja elukutsevalikust, Moskva aastaist, isiksustest teaduses ja poliitikas, poliitilise karjääri algusest ja erakonna valikust, naistest poliitikas

  6. Palo Verde College Facts, 2001.

    Science.gov (United States)

    Palo Verde Coll., Blythe, CA.

    This is a 2001 report on Palo Verde College (PVC) (California) student demographics, enrollment status, citizenship, educational goals, and academic persistence. Student data were collected and analyzed to meet accrediting standards, improve institutional effectiveness, and fulfill the local district's mission. The report discusses enrollment…

  7. Lõimumiseta pole Eesti turvaline / Urve Palo

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke 29. mai lk. 9. Rahvastikuminister Urve Palo selgitab, et integratsioon on alati kahepoolne protsess ja edukaks integratsiooniks on vaja valmisolekut ning kaasatust erinevatel ühiskonnatasanditel

  8. Burrowing Owl - Palo Verde Valley [ds197

    Data.gov (United States)

    California Department of Resources — These burrowing owl observations were collected during the spring and early summer of 1976 in the Palo Verde Valley, eastern Riverside County, California. This is an...

  9. Escuela Superior de Palos Verdes

    Directory of Open Access Journals (Sweden)

    Neutra, Richard J.

    1965-02-01

    Full Text Available Before initiating the building operations for the «Palos Verdes» School, the site was divided into two large horizontal surfaces, at different levels. The lower one served to accommodate the playing fields, a car park, the physical training building, and shop and ancillary buildings. On the higher of these two surfaces, and to the West of the access road, there is a car park and also the building and plot of ground devoted to agricultural technology, as well as the literary studies and general purpose buildings. As a complement to these, there is a series of blocks, arranged in parallel rows, which house the administrative offices, the art school, the craft's school, the general classrooms, and those devoted to higher education. The fascinating aspect of this school is the outstanding penetration of the architect's mind into the essential function of the project. Its most evident merit is the sense of comradeship and harmony that permeates the whole architectural manifold.Antes de construir el complejo escolar «Palos Verdes» se comenzó por crear, en el terreno, dos grandes mesetas a niveles diferentes. Sobre el inferior se organizaron: los campos de juegos, de deportes, un aparcamiento, el edificio para educación física y los destinados a tiendas y servicios. Sobre la meseta superior, al oeste de la vía de acceso, se dispuso un aparcamiento y el edificio y campo para adiestramiento agrícola; al este, otro aparcamiento, el edificio dedicado a materias literarias, y el destinado a usos múltiples. Completan las instalaciones de la escuela una serie de bloques paralelos: la administración, la escuela de arte, las clases de trabajos manuales, las aulas de enseñanzas generales, y las de los cursos superiores. Lo fascinante de este complejo escolar es la perfecta y magistral compenetración del arquitecto con el tema proyectado, y su mayor mérito, la sensación de cordialidad y armonía con el ambiente.

  10. Urve Palo : vabad lasteaiakohad on saavutatavad / Urve Palo ; interv. Vahur Koorits

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2007-01-01

    Rahvastikuminister Urve Palo vastab küsimustele, mis puudutavad pronkssõduri äraviimist ja hukkunute säilmete ümbermatmist, uute töötajate otsimist büroosse, integratsiooniprogrammi, tööd rahvastikuvaldkonnas, pereväärtusi ja lasteaiakohti. Kommenteerib Paul-Eerik Rummo. Lisa: Urve Palo

  11. Žene Frankopanke

    OpenAIRE

    Šercer, Marija

    2011-01-01

    Izabravši četrnaest žena koje su rođene kao Frankopanke, ili su udajom dospjele u obitelj Frankopan autorica je ukazala na uvjete u kojima su se ženska djeca udavala. Njihova dob od devet ili dvanaest godina, nedovoljno poznavanje budućega supruga, nepoznavanje sredine u koju su ih udavali, možebitno nepoznavanje jezika, otežavali su život toj nezreloj djeci. Temeljna zadaća ženskoga djeteta bila je rađanje djece i osiguravanje potomstva. Česti porodi su nerijetko dovodili do prerane smrti. T...

  12. Aasta tekstiilikunstnikuks valiti Ene Pars

    Index Scriptorium Estoniae

    2011-01-01

    Eesti Tekstiilikunstnike Liit valis aasta tekstiilikunstnikuks Ene Parsi. Aasta teo 2010 preemia vääriliseks tunnistati Kadri Viires. Preemiakandidaatide näitus avatakse 18. märtsil Tallinnas Hop galeriis

  13. Microbial synthesis of alka(enes

    Directory of Open Access Journals (Sweden)

    Weihua eWang

    2013-10-01

    Full Text Available Alka(enes are the predominant constituents of gasoline, diesel, and jet fuels. They can be produced naturally by a wide range of microorganisms. Bio- alka(enes can be used as drop-in biofuels. To date, five microbial pathways that convert free fatty acids or fatty acid derivatives into alka(enes have been identified or reconstituted. The discoveries open a door to achieve microbial production of alka(enes with high efficiency. The modules derived from these alka(ene biosynthetic pathways can be assembled as biological parts and synthetic biology strategies can be employed to optimize the metabolic pathways and improve alka(ene production.

  14. Urve Palo : mõ võpolnjajem postavlennõje tseli / Urve Palo

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2008-01-01

    Ilmunud ka: Põhjarannik 9. juuli 2008, lk. 2 ; Severnoje Poberezhje 9. juuli 2008, lk. 2. Rahvastikuminister Urve Palo väidab, et 8. juuli Eesti Päevalehes tema tegevuse aadressil esitatud kriitika sisaldab moonutatud ja ebaõigeid fakte

  15. DOE Zero Energy Ready Home Case Study: Palo Duro Homes — Palo Duro Homes, Albuquerque, NM

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-09-01

    This builder was honored for Most DOE Zero Energy Ready Homes Built in the 2014 Housing Innovation Awards. By July 2014, Palo Duro had completed 152 homes since the program began in 2013 (under the original program title DOE Challenge Home), all of them certified to the stringent efficiency requirements of DOE’s Zero Energy Ready Home program.

  16. Toetame lasteaedu ja lasteaia õpetajaid / Urve Palo

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2007-01-01

    Ilmunud ka: Põhjarannik, 7. sept. 2007, lk. 2; Severnoje Poberezhje, 7. sept. 2007, lk. 2; Meie Maa, 7. sept. 2007, lk. 2; Kuulutaja, 7. sept. 2007, lk. 4; Koit, 8. sept. 2007, lk. 5; Võrumaa Teataja, 8. sept. 2007, lk. 2; Vooremaa, 8. sept. 2007, lk. 2; Sakala, 11. sept. 2007, lk. 2; Nädaline, 11. sept. 2007, lk. 2; Pärnu Postimees, 12. sept. 2007, lk. 15; Valgamaalane, 13. sept. 2007, lk. 2; Hiiu Leht, 18. sept. 2007, lk. 2; Sõnumitooja, 19. sept. 2007, lk. 2; Maaleht, 20. sept. 2007, lk. 8; Nädalaleht, 7. sept. 2007, lk. 2. Rahvastikuminister Urve Palo kinnitusel eraldab uus valitsus rohkem kui kunagi varem raha uute lasteaedade ehituseks ja vanade renoveerimiseks, oluliseks sammuks on lasteaiaõpetajate palga tõstmine, tähelepanu all on piirkondlike erinevuste vähendamine palgatasemetes ning lasteaiaõpetajate palga viimine põhikooliõpetajate alampalga tasemele

  17. U russkoi molodjozhi jest shans / Urve Palo ; interv. Ilja Gromov

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2008-01-01

    Rahvastikuminister Urve Palo selgitab Avatud Ühiskonna Instituudi vene keelt kõnelevate noorte seas läbi viidud uuringu tulemusi. Lisa: Küsitlus: Kas vene keelt kõnelevatel noortel on Eestis hea elada

  18. Ene Sepp esitles esikteost "Medaljon" / Heli Talinurm

    Index Scriptorium Estoniae

    Talinurm, Heli

    2009-01-01

    Ene Sepp esitles 19. veebruaril Rapla Keskraamatukogus oma raamatut, mis pälvis kolmanda koha Eesti Lastekirjanduse Teabekeskuse ja kirjastuse Tänapäev 2008. aasta noorsooromaani võistlusel. Ly Ehini mõtteid, mida Ene Sepa raamat temas tekitas

  19. Heavy mineral provinces of the Palos Verdes margin, southern California

    Science.gov (United States)

    Wong, Florence L.

    2002-04-01

    Natural sources of sediment for the Palos Verdes margin, southern California, have been augmented by effluent discharged from Los Angeles County Sanitation District's sewage-treatment facility and by the reactivation of the Portuguese Bend landslide. Heavy minerals in very fine and fine sand (63-250 μm) from beach and shelf sites off the Palos Verdes Peninsula distinguish effluent-affected sediment from unaffected deposits, and track the sediment contributed by the Portuguese Bend landslide. Heavy minerals also identify heterogeneous sediment sources for the nearshore zone and relate outer-shelf sediment to depositional cells north and south of the area.

  20. Intervjuu rahvastikuminister Urve Paloga / Urve Palo ; interv. Harda Roosna

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2008-01-01

    Rahvastikuminister Urve Palo annab hinnangu Eesti saarte, sh. ka Hiiumaa demograafilisele olukorrale, uuele perekonnaseaduse eelnõule. Minister andis Kärdla ühisgümnaasiumis ühiskonnaõpetuse tundi. Vt. samas lk. 1: Harda Roosna. Minister vaimustus Super-isa projektist

  1. Timo Palo jäine väljakutse

    Index Scriptorium Estoniae

    2014-01-01

    Fotonäitusest "Jäine väljakutse". Näitus koosneb kahest osast: National Geographicu fotograafi Paul Nickleni fotodest "Polar Obsession" ja Eesti polaarränduri Timo Palo retke põhjapooluselt Teravmägede saarestikku kirjeldavast väljapanekust

  2. Urve Palo : rääkige lastele, et rahutused pole seotud rahvusega / Urve Palo ; interv. Anneli Ammas

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2007-01-01

    Rahvastikuminister Urve Palo on seisukohal, et integratsiooniküsimustes saab kõige kiiremini alustada koolidest; praegune olukord näitab, et vene koolide õpetajatega ei ole piisavalt tegeldud. Heaks näiteks integratsiooni kohta nimetab ta politseid, kus kõrvuti töötavad eestlased ja venelased

  3. Fitopreparati za žene u menopauzi

    OpenAIRE

    Peteljak, Ivana

    2015-01-01

    Menopauza predstavlja kraj fizioloških menstrualnih krvarenja, odnosno kraj reproduktivne dobi žene. Očituje se brojnim vazomotornim smetnjama i psihičkim promjenama. U želji da ublaže simptome menopauze žene posežu za hormonskom nadomjesnom terapijom, a u zadnje vrijeme i brojnim biljnim pripravcima. Ovaj rad daje pregled biljnih vrsta za koje se smatra da bi mogle poslužiti kao alternativa estrogenima za olakšanje simptoma menopauze. Znanstvena istraživanja su pokazala da je biljna vrsta Ci...

  4. preparation of bicyclic lactones using lewis acids catalyzed ene ...

    African Journals Online (AJOL)

    Administrator

    INTRODUCTION. The synthesis of the cis-fused bicyclic lactones relies extensively on the Lewis acid catalysed carbonyl-ene reaction which has been widely used to access carbocycles. In 1943 Alder discovered the ene-reaction and classified it in his Nobel Lecture as an “indirect substitution addition” or “ene synthesis" in ...

  5. ENES the European Network for Earth System modelling and its infrastructure projects IS-ENES

    Science.gov (United States)

    Guglielmo, Francesca; Joussaume, Sylvie; Parinet, Marie

    2016-04-01

    The scientific community working on climate modelling is organized within the European Network for Earth System modelling (ENES). In the past decade, several European university departments, research centres, meteorological services, computer centres, and industrial partners engaged in the creation of ENES with the purpose of working together and cooperating towards the further development of the network, by signing a Memorandum of Understanding. As of 2015, the consortium counts 47 partners. The climate modelling community, and thus ENES, faces challenges which are both science-driven, i.e. analysing of the full complexity of the Earth System to improve our understanding and prediction of climate changes, and have multi-faceted societal implications, as a better representation of climate change on regional scales leads to improved understanding and prediction of impacts and to the development and provision of climate services. ENES, promoting and endorsing projects and initiatives, helps in developing and evaluating of state-of-the-art climate and Earth system models, facilitates model inter-comparison studies, encourages exchanges of software and model results, and fosters the use of high performance computing facilities dedicated to high-resolution multi-model experiments. ENES brings together public and private partners, integrates countries underrepresented in climate modelling studies, and reaches out to different user communities, thus enhancing European expertise and competitiveness. In this need of sophisticated models, world-class, high-performance computers, and state-of-the-art software solutions to make efficient use of models, data and hardware, a key role is played by the constitution and maintenance of a solid infrastructure, developing and providing services to the different user communities. ENES has investigated the infrastructural needs and has received funding from the EU FP7 program for the IS-ENES (InfraStructure for ENES) phase I and II

  6. 968-IJBCS-Article-Ene Pascal Chuka

    African Journals Online (AJOL)

    T60

    indexmedicus.afro.who.int. Phenotypic assay of adherent E. coli strains using hep-2 cells on diarrheic children in Rivers State of Nigeria. Pascal Chuka ENE1*, Sam D. ABBEY1, Chukwudi Gregory MADUBUATTAH2 and. Chukwubuike Udoka OKEKE3.

  7. Tipparhitektuur tagasi kinnisvaraturul / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2008-01-01

    Müüki on pandud Ralf Tamme projekteeritud kuubikmaja Veskimöldres, Vahur Sova funkmaja Pirital, Kalle Rõõmuse eramu Merirahu elamurajoonis, Ene Priimetsa paarismaja Nõmmel, Mart Liho projekteritud maja Nõmmel. Ralf Tamme ja Tõnu Toomparki kommentaarid. Fotod elamutest

  8. Kandidaadid : Ene Ergma versus Toomas Hendrik Ilves

    Index Scriptorium Estoniae

    2006-01-01

    Artiklis vastatakse küsimustele, kes oleksid Kadriorus Ene Ergma ja Toomas Hendrik Ilvese nõunikud, millist sõnumit kannaks nende esimene iseseisvuspäeva kõne, kuidas nad tähistaksid oma võitu presidendivalimistel, kellele nad annaksid Maarjamaa Risti, kuhu nad teeksid oma esimese välisvisiidi

  9. Age of Palos Verdes submarine debris avalanche, southern California

    Science.gov (United States)

    Normark, W.R.; McGann, M.; Sliter, R.

    2004-01-01

    The Palos Verdes debris avalanche is the largest, by volume, late Quaternary mass-wasted deposit recognized from the inner California Borderland basins. Early workers speculated that the sediment failure giving rise to the deposit is young, taking place well after sea level reached its present position. A newly acquired, closely-spaced grid of high-resolution, deep-tow boomer profiles of the debris avalanche shows that the Palos Verdes debris avalanche fills a turbidite leveed channel that extends seaward from San Pedro Sea Valley, with the bulk of the avalanche deposit appearing to result from a single failure on the adjacent slope. Radiocarbon dates from piston-cored sediment samples acquired near the distal edge of the avalanche deposit indicate that the main failure took place about 7500 yr BP. ?? 2003 Elsevier B.V. All rights reserved.

  10. Modeling Educational Content: The Cognitive Approach of the PALO Language

    Directory of Open Access Journals (Sweden)

    M. Felisa Verdejo Maíllo

    2004-01-01

    Full Text Available This paper presents a reference framework to describe educational material. It introduces the PALO Language as a cognitive based approach to Educational Modeling Languages (EML. In accordance with recent trends for reusability and interoperability in Learning Technologies, EML constitutes an evolution of the current content-centered specifications of learning material, involving the description of learning processes and methods from a pedagogical and instructional perspective. The PALO Language, thus, provides a layer of abstraction for the description of learning material, including the description of learning activities, structure and scheduling. The framework makes use of domain and pedagogical ontologies as a reusable and maintainable way to represent and store instructional content, and to provide a pedagogical level of abstraction in the authoring process.

  11. Feminizam ili poslanje žene?

    OpenAIRE

    Mišić, Anto

    2005-01-01

    Premda ni feminizam ni poslanje žene nisu tipično filozofske (metafizičke) teme, filozofsko promišljanje pomaže jasnijem poimanju, žene, njezina odnosa i uloge u društvu. Bez ispravnog shvaćanja ljudske naravi, a ona jednako pripada ženi i muškarcu, lako se upada u jednostranost i isključivost stavova i djelovanja. Premda ljudska narav, osobnost, jednako pripada i muškarcu i ženi, ona se u njima ipak različito ostvaruje. Zbog individualnih razlika, ljudska se narav na različite načine izriče,...

  12. IS-ENES project management - lessons learnt

    Science.gov (United States)

    Parinet, Marie; Guglielmo, Francesca; Joussaume, Sylvie

    2017-04-01

    IS-ENES is the distributed e-infrastructure of models, model data and metadata of the European Network for Earth System Modelling (ENES). It has benefitted from two EC FP7 grants and aims towards further European and national funding to achieve sustainability. We highlight here several challenges related to project management that have risen in the course of these two project-phases spanning 8 years. Some challenges are related to the heterogeneity of the activities within IS-ENES, with different groups working on very diverse activities, not necessarily strictly interdependent. An immediate consequence is the need of implementing and setting up in early phases of the project efficient collection and circulation of information to preserve and reinforce the systemic view of the infrastructure as a whole and the pursuit of common goals, including coordinated provision of services. Toward and beyond such common goals, managing IS-ENES, covering both scientific and more strictly management-related aspects, implies a double-paced approach: besides setting up efficient project workflow, there is the need of setting up longer term objectives. This implies, within the project lifetime, to elaborate and implement a coherent organizational (consistent with scientific goals, funding schemes, research and technology landscape) strategy to pursue these goals beyond the project itself. Furthermore, a series of more generic project management challenges will also be listed and can be gathered around 3 main objectives: ease the internal processes in order to optimize the work, anticipate delays and budget issues, and motivate the project teams by ensuring an efficient internal and external communication.

  13. Kodanikupäev, kas ainult kalendri jaoks? / Urve Palo

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2007-01-01

    Ilmunud ka: Põhjarannik, 13. nov. 2007, lk. 4; Severnoje Poberezhje, 13. nov. 2007, lk. 4; Meie Maa, 13. nov. 2007, lk. 2; Valgamaalane, 13. nov. 2007, lk. 2; Nädalaleht, 9. nov. 2007, lk. 8; Lääne Elu, 15. nov. 2007, lk. 2; Koit, 15. nov. 2007, lk. 6; Virumaa Teataja, 22. nov. 2007, lk. 2; Pärnu Postimees, 24. nov. 2007, lk. 19. Rahvastikuminister Urve Palo sõnul on riigi ülesanne kindlustada turvaline Eesti riik - keskkond elamiseks, õppimiseks, töötamiseks, laste kasvatamiseks ning ühiskondlikuks tegevuseks

  14. Deposition and Accumulation of Emerging Contaminants in the Sediments of the Palos Verde Shelf, California

    Science.gov (United States)

    Deposition and Accumulation of Emerging Contaminants in the Sediments of the Palos Verde Shelf, California Mark G. Cantwell, David R. Katz, Julia Sullivan, Robert P. Eganhouse, Monique M. Perron, Robert M. Burgess The Palos Verdes shelf is located off the Southern California coa...

  15. Sa uurisid ekspressionismi 1960ndatel ja 70ndatel... / Ene Lamp

    Index Scriptorium Estoniae

    Lamp, Ene

    2005-01-01

    2004. a. ilmunud raamatu "Ekspressionism" eest Eesti Kultuurkapitali suure kunstipreemia (100000 kr.) saanud Ene Lamp ekspressionismi tähenduse muutumiset, ekspressionismi rollist eesti kunstis, oma tulevikuplaanidest

  16. Ene Ergma : riigikogu liikme töökoht on riigikogus / Ene Ergma

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2007-01-01

    Riigikogu esimees vastab EPL Online'i lugejate küsimustele, mis muuhulgas puudutavad ka president Toomas Hendrik Ilvese ideed muuta kaitseväe juhataja ametisse määramise korda. Ene Ergma kiidab ka presidendi kõnet Riigikogu XI koosseisu avaistungil

  17. Ene-Liis Semper kodustab ruume / Ene-Liis Semper ; intervjueerinud Liina Luhats

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2011-01-01

    Video- ja teatrikunstnik Ene-Liis Semper oma Kumu Kunstimuuseumis 31. dets.-ni 2011 avatud näitusest, mis räägib ajast ja ajalikkusest ning inimesekolemisest selles, oma loomingust, valdkondade vahel liikumisest, tööst NO99 teatris, loomingulistest plaanidest

  18. Thiol-Ene Networks for Photon Upconversion

    Science.gov (United States)

    Lott, Joseph; Jentsch, Abagail

    Photon upconversion via the mechanism of triplet-triplet annihilation (TTA) offers the prospect of employing low-power and non-coherent excitation sources to drive the upconversion process. Solid-state materials capable of TTA present several significant challenges including limited solubility of the required chromophores and reduced molecular diffusion. Owing to the wide range of chemical compositions, tunable mechanical properties, and the ease of processing, polymeric materials have been at the forefront of solid-state materials for TTA. This study focuses on the use of thiol-ene `click' chemistry to create elastomeric films for TTA. Functionalized derivatives of 9,10-diphenylanthracene bearing two vinyl groups were synthesized and covalently incorporated into thiol-ene films, along with palladium (II) octaethylporphine as a sensitizing chromophore. Both emitter and sensitizer concentrations were systematically varied. The network formation was monitored using FTIR measurements and leaching experiments were conducted to quantify the amount of emitter chromophores not bonded into the network. The thermal and mechanical properties of the films were characterized using TGA, DSC, and DMTA. The upconverting performance was gauged using steady-state photoluminescence and lifetime measurements.

  19. Name, location, and length of sediment cores collected in 2009 offshore from Palos Verdes, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of the data release is a spreadsheet including the name, location, and length of sediment cores collected in 2009 offshore from Palos Verdes, California....

  20. Continuous core photographs of sediment cores collected in 2009 offshore from Palos Verdes, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of the data release includes continuous core photographs in bmp format of sediment cores collected in 2009 offshore of Palos Verdes, California. It is one...

  1. Raw computed tomography (CT) images of sediment cores collected in 2009 offshore from Palos Verdes, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of the data release includes raw computed tomography (CT) images of sediment cores collected in 2009 offshore of Palos Verdes, California. It is one of...

  2. Grain-size analysis of sediment cores collected in 2009 offshore from Palos Verdes, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of the data release includes grain-size analysis of sediment cores collected in 2009 offshore of Palos Verdes, California. It is one of seven files...

  3. Wetlands at Palo Alto Battlefield National Historic Site and Surrounding Areas, Texas

    Data.gov (United States)

    National Park Service, Department of the Interior — This is a vector polygon coverage of wetlands at and surronding Palo Alto Battlefield National Historic Site, Texas. Roughly 20% of the park can be classified as...

  4. Graphical representations of data from sediment cores collected in 2009 offshore from Palos Verdes, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of the data release includes graphical representation (figures) of data from sediment cores collected in 2009 offshore of Palos Verdes, California. This...

  5. Structural geometry and gravity constraints on the Palos Verdes and Cabrillo faults

    Science.gov (United States)

    Cengelcik, Yeliz

    The thesis presents and evaluates five new gravity constrained structural cross-sections about the Palos Verdes and Cabrillo faults of southern California. They both have been active since the Miocene, however the Palos Verdes fault zone is considered to be a greater seismic hazard. Using geologic, gravity and seismic data we present new interpretations about the geometry of the Palos Verdes and Cabrillo faults. In the San Pedro and Los Angeles Harbor region approximately125 new gravity data were collected with a Worden gravimeter and new structural cross-sections were constructed by using data of our gravity surveying. The collected data displays a Simple Bouguer gravity anomaly high near the Cabrillo fault and northwards toward the Palos Verdes fault there is an approximately 30 mGal decrease. The Palos Verdes fault itself is characterized by an inflection in the gravity data and a relatively flat zone immediately to the north. This shelf in the gravity data is important because the highly productive Wilmington Oil Field is located in this area and it is likely a product of the particular geometry in the region. The Palos Verdes fault also forms the edge of the larger Los Angeles Basin. Our basic interpretation is that the Palos Verdes and Cabrillo faults are primarily strike slip faults. However, a horst-like block between the two faults has been uplifted and horizontally shortened. Our main interpretation is that Catalina Schist basement uplift and subsequent basin fill to the north is responsible for the large negative gravity anomalies associated with the Palos Verdes fault.

  6. An academic with ambition / Ene Ergma ; interv. Kadri Kukk

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2006-01-01

    Intervjuus Riigikogu asespiikriga käsitletakse kõrghariduse korraldust, professorite rohkust kõrgkoolides, võimalikku kandideerimist Tartu ülikooli rektori kohale, omandatud poliitilisi kogemusi ning ajude äravoolu Eestist. Ene Ergma CV

  7. 5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry.

    Science.gov (United States)

    Kaminskyy, Danylo; Kryshchyshyn, Anna; Lesyk, Roman

    2017-11-10

    The presented review is an attempt to summarize a huge volume of data on 5-ene-4-thiazolidinones being a widely studied class of small molecules used in modern organic and medicinal chemistry. The manuscript covers approaches to the synthesis of 5-ene-4-thiazolidinone derivatives: modification of the C5 position of the basic core; synthesis of the target compounds in the one-pot or multistage reactions or transformation of other related heterocycles. The most prominent pharmacological profiles of 5-ene derivatives of different 4-thiazolidinone subtypes belonging to hit-, lead-compounds, drug-candidates and drugs as well as the most studied targets have been discussed. Currently target compounds (especially 5-en-rhodanines) are assigned as frequent hitters or pan-assay interference compounds (PAINS) within high-throughput screening campaigns. Nevertheless, the crucial impact of the presence/nature of C5 substituent (namely 5-ene) on the pharmacological effects of 5-ene-4-thiazolidinones was confirmed by the numerous listed findings from the original articles. The main directions for active 5-ene-4-thiazolidinones optimization have been shown: i) complication of the fragment in the C5 position; ii) introduction of the substituents in the N3 position (especially fragments with carboxylic group or its derivatives); iii) annealing in complex heterocyclic systems; iv) combination with other pharmacologically attractive fragments within hybrid pharmacophore approach. Moreover, the utilization of 5-ene-4-thiazolidinones in the synthesis of complex compounds with potent pharmacological application is described. The chemical transformations cover mainly the reactions which involve the exocyclic double bond in C5 position of the main core and correspond to the abovementioned direction of the 5-ene-4-thiazolidinone modification. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  8. Hexaarylbiimidazoles as Visible Light Thiol–Ene Photoinitiators

    Science.gov (United States)

    Clarkson, Brian H.; Scott, Timothy F.

    2015-01-01

    Objectives The aim of this study is to determine if hexaarylbiimidazoles (HABIs) are efficient, visible light-active photoinitiators for thiol–ene systems. We hypothesize that, owing to the reactivity of lophyl radicals with thiols and the necessarily high concentration of thiol in thiol–ene formulations, HABIs will effectively initiate thiol–ene polymerization upon visible light irradiation. Methods UV-vis absorption spectra of photoinitiator solutions were obtained using UV-vis spectroscopy, while EPR spectroscopy was used to confirm radical species generation upon HABI photolysis. Functional group conversions during photopolymerization were monitored using FTIR spectroscopy, and thermomechanical properties were determined using dynamic mechanical analysis. Results The HABI derivatives investigated exhibit less absorptivity than camphorquinone at 469 nm; however, they afford increased sensitivity at this wavelength when compared with bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide. Photolysis of the investigated HABIs affords lophyl radicals. Affixing hydroxyhexyl functional groups to the HABI core significantly improved solubility. Thiol–ene resins formulated with HABI photoinitiators polymerized rapidly upon irradiation with 469 nm. The glass transition temperatures of the thiol–ene resin formulated with a bis(hydroxyhexyl)-functionalized HABI and photopolymerized at room and body temperature were 49.5±0.5°C and 52.2±0.1°C, respectively. Significance Although thiol–enes show promise as continuous phases for composite dental restorative materials, they show poor reactivity with the conventional camphorquinone/tertiary amine photoinitiation system. Conversely, despite their relatively low visible light absorptivity, HABI photoinitiators afford rapid thiol–ene photopolymerization rates. Moreover, minor structural modifications suggest pathways for improved HABI solubility and visible light absorption. PMID:26119702

  9. The diagenetic fate of taraxer-14-ene and oleanene isomers

    Energy Technology Data Exchange (ETDEWEB)

    Ten Haven, H.L.; Rullkoetter, J. (Institute of Petroleum and Organic Geochemistry, Juelich (West Germany))

    1988-10-01

    The extractable organic matter in Holocene to early Miocene deep-sea sediments from Site 645 (ODP Leg 105) in Baffin Bay contains almost exclusively biological markers of terrigenous origin. Pentacyclic triterpenoids of the {alpha}-(ursene) and {beta}-amyrin (oleanene) type often occur as the most abundant compounds in the aliphatic hydrocarbon, ketone and alcohol fractions of the sediment extract. A specific diagenetic reaction involves the conversion of taraxer-14-ene into olean-12-ene in the upper 700 meters of the sedimentary sequence. The taraxerene-to-oleanene conversion is complete before the onset of isomerization of diasterenes at C-20. In the sediment as well as in laboratory simulation experiments, olean-12-ene further isomerizes to olean-13(18)-ene and olean-18-ene, the latter of which may be the direct precursor of 18{beta}(H)- and 18{alpha}(H)-oleanane found in sediments containing more mature organic matter and in crude oils. The subsurface interconversion of these triterpenoid skeletons indicate that oleanane does not necessarily start life as an oleanoid.

  10. ZOOARQUEOLOGÍA DE LA ALDEA FORMATIVA DE PALO BLANCO (TINOGASTA, CATAMARCA, ARGENTINA / Zooarchaeology of the formative village of Palo Blanco (Tinogasta, Catamarca, Argentina

    Directory of Open Access Journals (Sweden)

    Juan Pablo Miyano

    2015-12-01

    Full Text Available En el presente trabajo se abordan los conjuntos arqueofaunísticos de la localidad arqueológica de Palo Blanco recuperados en intervenciones realizadas en la década de 1960 y en la década de 2000. Esta localidad se encuentra emplazada en el sector norte del bolsón de Fiambalá (Tinogasta, Catamarca y se compone de varios núcleos habitacionales de distribución dispersa, predominantemente rectangulares y con muros de tapia. Su ocupación no fue sincrónica y se extiende desde el siglo III al siglo X A.D. La tendencia en el aprovechamiento de recursos faunísticos identificada fundamentalmente a partir del abordaje de los conjuntos de dos núcleos habitacionales sugiere que los camélidos fueron el principal recurso de origen animal utilizado en la aldea, en donde se encontraron especies tanto domesticadas (Lama glama como silvestres (Vicugna vicugna. Además, la presencia predominante de camélidos subadultos sugiere una estrategia de pastoreo vinculada al aprovechamiento de recursos primarios como carne, médula y grasa. Los resultados a los que se arribaron permiten profundizar en el conocimiento de las actividades económicas de los grupos humanos que habitaron la aldea de Palo Blanco a lo largo del primer milenio de la era. AbstractIn this paper we approach the archaeofaunistic remains recovered during excavations of the archeological locality of Palo Blanco in the decades of 1960 and 2000. Palo Blanco is located in the north sector of the Bolsón of Fimabalá area (Tinogasta, Catamarca and it is composed of several rectangular shaped dwellings with tapia-style walls and dispersed distribution. The period of occupation of the village was between the third and tenth century A.D. although the dwellings were not inhabited synchronously. The identified tendency in the exploitation of faunal resources indicates that the camelids were the main resources. Osteometric studies show that domestic and wild camelids (Lama glama and Vicugna vicugna

  11. 75 FR 8149 - Arizona Public Service Company, et al. Palo Verde Nuclear Generating Station, Units 1, 2, and 3...

    Science.gov (United States)

    2010-02-23

    ... COMMISSION Arizona Public Service Company, et al. Palo Verde Nuclear Generating Station, Units 1, 2, and 3... NPF-74, issued to the Arizona Public Service Company (APS, or the licensee), for operation of the Palo..., respectively). Documents may be examined, and/or copied for a fee, at the NRC's Public Document Room (PDR...

  12. ¿QUÉ PERCEPCIÓN TENEMOS DE LOS INSECTOS-PALO (Insecta: Phasmatodea?

    Directory of Open Access Journals (Sweden)

    MAURICIO VARGAS C.

    2006-01-01

    Full Text Available Se realizó un estudio compilatorio acerca de la relación que tienen las personas con los insectos palo (e insectos hoja; Insecta: Phasmatodea. Se destaca la importancia que tienen estos insectos en diferentes culturas, la forma de apreciarlos, percibirlos e interactuar con ellos. Se describen algunos aspectos etnotaxonómicos, de credo, usos y costumbres, representaciones gráficas, producciones literarias y cinematográficas de estos insectos en distintos grupos humanos. Se propone el estudio de la Etnofasmatología como disciplina dedicada a conocer las relaciones que tienen las distintas culturas con los insectos palo y hoja.

  13. Ene Ergma kihutas Valka 120 kilomeetrit tunnis / Kadi Viljak, Siim Randla

    Index Scriptorium Estoniae

    Viljak, Kadi

    2003-01-01

    Riigikogu spiiker Ene Ergma kasutas Valga kultuurikeskusesse valijatega kohtumisele jõudmiseks ametiautol vilkurit, mis lubab hoida kiirust vähemalt 120 kilomeetrit tunnis. Novembrikuus on Ene Ergma autojuht registreerinud alarmsõitu kaheksal korral

  14. 75 FR 52045 - Arizona Public Service Company, Palo Verde Nuclear Generating Station, Unit 3; Environmental...

    Science.gov (United States)

    2010-08-24

    ... COMMISSION Arizona Public Service Company, Palo Verde Nuclear Generating Station, Unit 3; Environmental... Operating License No. NPF-74, issued to Arizona Public Service Company (APS, the licensee), for operation of... the public health and safety. The NRC-approved Westinghouse Electric Company LLC (Westinghouse...

  15. Agrochemical characterization of vermicomposts produced from residues of Palo Santo (Bursera graveolens) essential oil extraction

    DEFF Research Database (Denmark)

    Carrión-Paladines, Vinicio; Fries, Andreas; Gomez Muñoz, Beatriz

    2016-01-01

    Fruits of Palo Santo (Bursera graveolens) are used for essential oil extraction. The extraction process is very efficient, because up to 3% of the fresh fruits can be transformed into essential oil; however, a considerable amount of waste is concurrently produced (>97% of the fresh biomass). Recent...

  16. "Mul ei ole infot. Ma ei varja midagi!" / Urve Palo ; interv. Tarmo Vahter

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2007-01-01

    Rahvastikuminister Urve Palo sõnul peab pronkssõduriga tegelema väga ettevaatlikult, tuleb teha palju selgitustööd, selles peavad osalema ka teised ministeeriumid. Vt. samas: Küsitlus: pronkssõdur ei huvita peaaegu kedagi

  17. Ene ja Tõnis Kask pole valikuga rahul / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2003-01-01

    Eesti Filmiajakirjanike Ühing andis auhinna Aasta film 2002 mängufilmile "Agent Sinikael" : režissöör Marko Raat. Viimane sai preemiaks 12 000 krooni. Auhinna rahastajad omanimelise fondi kaudu Eesti Rahvuskultuuri Fondi juures Ene ja Tõnis Kask peavad "Nimed marmortahvlil" väljajätmist isegi nominentide hulgast shokeerivaks

  18. Evidence for distinct dehydrogenase and isomerase sites within a single 3. beta. -hydroxysteroid dehydrogenase/5-ene-4-ene isomerase protein

    Energy Technology Data Exchange (ETDEWEB)

    Luu-The, V.; Takahashi, Masakazu; de Launoit, Y.; Dumont, M.; Lachance, Y.; Labrie, F. (Laval Univ., Quebec City, Quebec (Canada))

    1991-09-10

    Complementary DNA encoding human 3{beta}-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3-{beta}-HSD) has been expressed in transfected GH{sub 4}C{sub 1} with use of the cytomegalovirus promoter. The activity of the expressed protein clearly shows that both dehydrogenase and isomerase enzymatic activities are present within a single protein. However, such findings do not indicate whether the two activities reside within one or two closely related catalytic sites. With use of ({sup 3}H)-5-androstenedione, the intermediate compound in dehydroepiandrosterone (DHEA) transformation into 4-androstenedione by 3{beta}-HSD, the present study shows that 4MA (N,N-diethyl-4-methyl-3-oxo-4-aza-5{alpha}-androstane-17{beta}-carboxamide) and its analogues of 5-androstenedione to 4-androstenedione with an approximately 1,000-fold higher K{sub i} value. The present results thus strongly suggest that dehydrogenase and isomerase activities are present at separate sites on the 3-{beta}-HSD protein. Such data suggest that the irreversible step in the transformation of DHEA to 4-androstenedione is due to a separate site possessing isomerase activity that converts the 5-ene-3-keto to a much more stable 4-ene-3-keto configuration.

  19. Ene Ergma ja Toomas Hendrik Ilves : presidendikampaania kipub palaganiks / Ene Ergma, Toomas Hendrik Ilves ; interv. Kalev Vilgats

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2006-01-01

    Presidendikandidaadid Ene Ergma ja Toomas Hendrik Ilves annavad omapoolsed hinnangud eelolevatele presidendivalimistele. Vt. samas: Eesti Vabariigi presidendi valimise kord. Vt. ka Riina Martinsoni lühiinterv. Riigikogu liikmete Koit Pikaro, Mark Soosaare, Jaanus Männiku, Väino Linde, Trivimi Velliste, Toomas Alatalu, Aivar Õuna ja Ela Tomsoniga

  20. Ene Ergma : ikka otsitakse ju heledate lokkis juustega tüdrukuid / Ene Ergma ; interv. Märt Kivine

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2006-01-01

    Res Publica presidendikandidaadi sõnul on Eesti presidendi roll olla Eesti riigi nägu väljapoole. Presidendil on hiiglaslik vastutus, mitte niivõrd palju võimu, ta peab tajuma, kus on ühiskonna valulävi. CV: Ene Ergma

  1. Radiocarbon sample data and calibrated ages of sediment cores collected in 2009 offshore from Palos Verdes, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of the data release is a spreadsheet including radiocarbon sample information and calibrated ages of sediment cores collected in 2009 offshore of Palos...

  2. Digital Geologic Map of Palo Alto Battlefield National Historic Site and vicinity, Texas (NPS, GRD, GRE, PAAL, PAAL digital map)

    Data.gov (United States)

    National Park Service, Department of the Interior — The Digital Geologic Map of Palo Alto Battlefield National Historic Site and vicinity, Texas is composed of GIS data layers complete with ArcMap 9.2 layer (.LYR)...

  3. 5 küsimust Ene Läkile / Ene Läkk ; interv. Ell-Maaja Randküla

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2006-01-01

    Ene Läkist, kes on alates 2005. aastast interjööri-, disaini- ja arhitektuuriajakirja "Ruum" peatoimetaja. Ene Läkk, Eesti Sisearhitektide Liidu 2005. a. aastapreemia nominent ajakirjandusliku tegevuse eest, ajakirjast "Ruum". Ill.: 6 värv. vaadet, foto ajakirjanikust

  4. Teekond kogunemisest koostööni / Ene Kulasalu, Ene Velström, Koidu Tani-Jürisoo, Mari Karm ; vahendas Mari Karm

    Index Scriptorium Estoniae

    2003-01-01

    Vestlusringis on Avatud Meele Instituudi koolitajad Ene Kulasalu, Ene Velström, Koidu Tani-Jürisoo ja Mari Karm, et arutada koostöö ja selle juhtimise võimalikkust ja vajalikkust, grupi arengufaaside (sõltuvusfaas, konfliktifaas, eraldumisfaas, koostööfaas) toimimist ja nende teadvustamise tähtsust

  5. Ene-Liiz Semper. Anton Litvin. Bogdan Mamonov

    Index Scriptorium Estoniae

    2005-01-01

    Veebruaris Madridis toimunud Euroopa kunstilaada ARCO jaoks Vene saatkonna galerii poolt koostatud kunstinäitus TRINITY toimub nüüd Tallinnas Vene saatkonna galeriis. Kuraatorid Masha ja Andrei Melnikovid. Osalevad Ene-Liis Semper videoga ArtVideo, vene kunstnik Bogdan Mamonov maaliseeriaga "Ma kanoniseerisin oma sõpru" ja vene kunstnik Anton Litvin fotoprojektiga "Punktuatsioon". Madridis näitas Semper videot "Nimetu"

  6. Functional Conducting Polymers via Thiol-ene Chemistry

    OpenAIRE

    Feldman, Kathleen E.; Martin, David C.

    2012-01-01

    We demonstrate here that thiol-ene chemistry can be used to provide side-chain functionalized monomers based on 3,4-propylenedioxythiophene (ProDOT) containing ionic, neutral, hydrophobic, and hydrophilic side chains. All reactions gave high yields and purification could generally be accomplished through precipitation. These monomers were polymerized either chemically or electro-chemically to give soluble materials or conductive films, respectively. This strategy provides for facile tuning of...

  7. Interpretation of underpressuring using pressure-depth profiles, Palo Duro basin, Texas

    Energy Technology Data Exchange (ETDEWEB)

    Orr, E.D.; Kreitler, C.W.

    1984-04-01

    In the Palo Duro basin, the problems of the hydrogeologic setting are reduced by delineating regions with little variation in surface topography and structure. The P-D plots for these different regions vary considerably. To evaluate the effect of the hydrogeologic setting on these P-D plots, theoretical models of hydrostatic conditions were computed for the hydrogeologic setting of each region. Comparison of regression lines through real P-D data to those through modeled data distinguishes true hydrologic conditions from the misleading effects of the hydrogeologic setting. P-D plots indicate regional underpressuring in Palo Duro basin. Variations in potential vertical flow within the underpressured basin are indicated by variations in P-D gradients across the basin. Potential upward flow is indicated along the western flanks of the Amarillo uplift, while potential downward flow is indicated in the southwestern and eastern parts of the basin.

  8. ¿QUÉ PERCEPCIÓN TENEMOS DE LOS INSECTOS-PALO (Insecta: Phasmatodea)?

    OpenAIRE

    MAURICIO VARGAS C.

    2006-01-01

    Se realizó un estudio compilatorio acerca de la relación que tienen las personas con los insectos palo (e insectos hoja; Insecta: Phasmatodea). Se destaca la importancia que tienen estos insectos en diferentes culturas, la forma de apreciarlos, percibirlos e interactuar con ellos. Se describen algunos aspectos etnotaxonómicos, de credo, usos y costumbres, representaciones gráficas, producciones literarias y cinematográficas de estos insectos en distintos grupos humanos. Se propone el estudio ...

  9. Risk-based inservice testing program modifications at Palo Verde nuclear generating station

    Energy Technology Data Exchange (ETDEWEB)

    Knauf, S.; Lindenlaub, B.; Linthicum, R.

    1996-12-01

    Arizona Public Service Company (APS) is investigating changes to the Palo Verde Inservice Testing (IST) Program that are intended to result in the reduction of the required test frequency for various valves in the American Society of Mechanical Engineers (ASME) Section XI IST program. The analytical techniques employed to select candidate valves and to demonstrate that these frequency reductions are acceptable are risk based. The results of the Palo Verde probabilistic risk assessment (PRA), updated in June 1994, and the risk significant determination performed as part of the implementation efforts for 10 CFR 50.65 (the maintenance rule) were used to select candidate valves for extended test intervals. Additional component level evaluations were conducted by an `expert panel.` The decision to pursue these changes was facilitated by the ASME Risk-Based Inservice Testing Research Task Force for which Palo Verde is participating as a pilot plant. The NRC`s increasing acceptance of cost beneficial licensing actions and risk-based submittals also provided incentive to seek these changes. Arizona Public Service is pursuing the risk-based IST program modification in order to reduce the unnecessary regulatory burden of the IST program through qualitative and quantitative analysis consistent with maintaining a high level of plant safety. The objectives of this project at Palo Verde are as follows: (1) Apply risk-based technologies to IST components to determine their risk significance (i.e., high or low). (2) Apply a combination of deterministic and risk-based methods to determine appropriate testing requirements for IST components including improvement of testing methods and frequency intervals for high-risk significant components. (3) Apply risk-based technologies to high-risk significant components identified by the {open_quotes}expert panel{close_quotes} and outside of the IST program to determine whether additional testing requirements are appropriate.

  10. Perekond on kõige tähtsam / Urve Palo

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2007-01-01

    Ilmunud ka: Hiiu Leht, 21. dets. 2007, lk. 2; Pärnu Postimees, 21. dets. 2007, lk. 15; Severnoje Poberezhje, 21. dets. 2007, lk. 2; Nädalaleht, 21. dets. 2007, lk. 2; Koit, 22. dets. 2007, lk. 6; Meie Maa, 22. dets. 2007, lk. 2; Molodjozh Estonii, 29. dets. 2007, lk. 4; Võrumaa Teataja, 5. jaan. 2008, lk. 3; Järva Teataja, 5. jaan. 2008, lk. 2. Rahvastikuminister Urve Palo jõulu- ja aastalõputervitus

  11. Multi-chamber and multi-layer thiol-ene microchip for cell culture

    DEFF Research Database (Denmark)

    Tan, H. Y.; Hemmingsen, Mette; Lafleur, Josiane P.

    2014-01-01

    We present a multi-layer and multi-chamber microfluidic chip fabricated using two different thiol-ene mixtures. Sandwiched between the thiol-ene chip layers is a commercially available membrane whose morphology has been altered with coatings of thiol-ene mixtures. Experiments have been conducted ...... with the microchip and shown that the fabricated microchip is suitable for long term cell culture....

  12. IS-ENES: The Infrastructure for the European Network for Earth System modelling

    Science.gov (United States)

    Joussaume, Sylvie

    2013-04-01

    IS-ENES is the distributed e-infrastructure of models, model data and metadata of the European Network for Earth System Modelling (ENES). This network gathers together the European climate modelling community working on understanding and predicting climate variability and change. It organizes and supports European contributions to international experiments used in assessments of the Intergovernmental Panel on Climate Change, such as the Fifth Coupled Model Intercomparison Project (CMIP5) and the Coordinated regional Climate Downscaling Experiments (CORDEX). IS-ENES is supported by FP7 and is entering its second 4-year phase (http://is.enes.org). IS-ENES integrates the European climate modelling community, stimulates common developments of software for models and their environments, fosters the execution and exploitation of high-end simulations, in particular using the European PRACE facilities, and supports the dissemination of model results to the climate research and climate impact communities. The central point of entry to IS-ENES services, the ENES Portal (http://enes.org), integrates information on the European climate models and provides access to models and software environments needed to run and exploit model simulations, such as the climate data operators, as well as to simulation data, metadata and processing utilities. IS-ENES supports the European contribution to the international Earth System Grid Federation data distribution for CMIP5 and CORDEX. In order to help the use of climate model results for impact studies, e.g. in water management, a prototype portal climate4impact (http://www.climate4impact.eu) has been developed providing access to guidance on how to use global climate model results through documentation of use cases, and will be further developed in IS-ENES2. Adaptation to climate change requires strengthening the integration between the climate and hydro-meteorological communities and the e-infrastructure IS-ENES2 might contribute to this

  13. Naknada štete prouzročene kaznenim djelom

    OpenAIRE

    Votić, Antonija

    2016-01-01

    Tema ovog završnog rada je naknada štete prouzročene kaznenim djelom. U tom radu autorica je obuhvatila sljedeća poglavlja; opće i posebne pretpostavke odgovornosti za štetu, subjekte obveznog odnosa odgovornosti za štetu, nadalje vrste odgovornosti, vlastitu odgovornost, odgovornost za drugoga i odgovornost više osoba za istu štetu zatim je objasnila posebne slučajeve odgovornosti, popravljanje štete te uklanjanje opasnosti štete. Autorica je posebnu pozornost pridodala poglavljima o kazn...

  14. Agrochemical characterization of vermicomposts produced from residues of Palo Santo (Bursera graveolens) essential oil extraction.

    Science.gov (United States)

    Carrión-Paladines, Vinicio; Fries, Andreas; Gómez-Muñoz, Beatriz; García-Ruiz, Roberto

    2016-12-01

    Fruits of Palo Santo (Bursera graveolens) are used for essential oil extraction. The extraction process is very efficient, because up to 3% of the fresh fruits can be transformed into essential oil; however, a considerable amount of waste is concurrently produced (>97% of the fresh biomass). Recent developments in Ecuadorian policies to foster environmentally friendly agroforestry and industrial practices have led to widespread interest in reusing the waste. This study evaluated the application of four vermicomposts (VMs), which are produced from the waste of the Palo Santo fruit distillation in combination with other raw materials (kitchen leftovers, pig manure, goat manure, and King Grass), for agrochemical use and for carbon (C) and nitrogen (N) decomposition in two soils with different textures. The results showed that the vermicompost mixtures (VMM) were valuable for agricultural utilisation, because total N (min. 2.63%) was relatively high and the C/N ratio (max. 13.3), as well as the lignin (max. 3.8%) and polyphenol (max. 1.6%) contents were low. In addition, N availability increased for both soil types after the application of the VMM. In contrast, N became immobile during decomposition if the VM of the pure waste was added. This likely occurred because of the relatively low total N (1.16%) content and high C/N ratio (35.0). However, the comparatively low C decomposition of this VM type makes its application highly recommendable as a strategy to increase the levels of organic matter and C, as well as for soil reclamation. Overall, these results suggest that the residues of the Palo Santo essential oil extraction are a potential source for vermicompost production and sustainable agriculture. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Palos Verdes Shelf oceanographic study; data report for observations December 2007–April 2008

    Science.gov (United States)

    Rosenberger, Kurt J.; Noble, Marlene A.; Sherwood, Christopher R.; Martini, Marinna M.; Ferreira, Joanne T.; Montgomery, Ellyn T.

    2011-01-01

    Beginning in 1997, the Environmental Protection Agency (EPA) defined a contaminated section of the Palos Verdes Shelf region in southern California as a Superfund Site, initiating a continuing investigation of this area. The investigation involved the EPA, the U.S. Geological Survey (USGS), Science Applications International Corporation (SAIC), Los Angeles County Sanitation Districts (LACSD) data, and other allied agencies. In mid-2007, the Palos Verdes Shelf project team identified the need for additional data on the sediment properties and oceanographic conditions at the Palos Verdes Superfund Site and deployed seven bottom platforms, three subsurface moorings, and three surface moorings on the shelf. This additional data was needed to support ongoing modeling and feasibility studies and to improve our ability to model the fate of the effluent-affected deposit over time. It provided more detail on the spatial variability and magnitude of resuspension of the deposit during multiple storms that are expected to transit the region during a winter season. The operation began in early December 2007 and ended in early April 2008. The goal was to measure the sediment response (threshold of resuspension, suspended-sediment concentrations, and suspended-sediment transport rates) to bed stresses associated with waves and currents. Other objectives included determining the structure of the bottom boundary layer (BBL) relating nearbed currents with those measured at 10 m above bottom (mab) and comparing those with the long-term data from the LACSD Acoustic Doppler Current Profiler (ADCP) deployments for nearbed current speed and direction. Low-profile tripods with high-frequency ADCPs co-located with two of the large tripods were selected for this goal. This report describes the data obtained during the field program, the instruments and data-processing procedures used, and the archive that contains the data sets that have passed our quality-assurance procedures.

  16. Fabrication of a microfluidic cell made of thiol-ene for microarray applications

    DEFF Research Database (Denmark)

    Sola, Laura; Gagni, Paola; Jensen, Thomas G.

    2014-01-01

    We report on the fabrication of a microfluidic cell completely made of thiol-ene for microarray applications. To overcome the issues related to the hydrophobic nature of the thiol-ene material we have also introduced a new polymeric coating based of N, N-dimethylacrylamide (DMA) which is able to ...

  17. Structural Inversion of the Palos Verdes Fault, Southern California, and its Implications for Seismic Hazards Assessment

    Science.gov (United States)

    Brankman, C. M.; Shaw, J. H.

    2004-12-01

    The Palos Verdes Fault (PVF) defines the western margin of the Los Angeles basin, and is regarded as a likely source of moderate to large earthquakes that would affect the coastal metropolitan regions of southern California. In most hazard compilations, the PVF is generally considered to be a vertical, predominantly right-lateral, strike-slip fault system that extends continuously from the Santa Monica thrust southward across Santa Monica Bay, crossing the Palos Verdes Peninsula and continuing southeast across the Inner Borderlands to the area of Coronado Banks. A restraining bend where the fault dips steeply to the southwest generates uplift and folding of the Palos Verdes Peninsula. However, previous studies documenting the activity, slip rate, and slip sense of the PVF have used shallow subsurface excavations and high-frequency seismic data, which have generally limited observations to the upper kilometer of the crust. We use an extensive grid of petroleum industry seismic reflection data and well logs to define the three-dimensional subsurface geometry of the PVF in the region south of the Palos Verdes Peninsula. Our seismic data cover the complete offshore extent of the fault, from Santa Monica Bay to the Coronado Banks, and provide direct constraints on the fault geometry extending down to about 5km depth. We use the shapes of folded strata imaged in the seismic data and penetrated by wells to invert for permissible geometries of the fault as it extends to the base of the seismogenic crust. Our data and structural analyses indicate that the PVF developed by Pliocene inversion of a Miocene normal fault system. The fault has a significant component of reverse slip and southwesterly dip at depth along its extent. Oblique displacement on the fault appears to be partitioned at shallow levels into nearly pure right-lateral strike slip on near-vertical faults and contractional folding above gently to moderately dipping blind-thrust fault splays. These observations

  18. Macroinvertebrados bentónicos del humedal de Palo Verde, Costa Rica

    Directory of Open Access Journals (Sweden)

    F.A Trama

    2009-11-01

    Full Text Available El humedal de Palo Verde es uno de los más importantes de Centro America para aves acuáticas. Durante el período 2002 y 2005, se llevaron a cabo actividades de manejo para controlar la invasión de Typha domingensis. Con el fin de establecer una línea base para monitoreos futuros, en el 2003 se realizó una evaluación de macroinvertebrados acuáticos. Se efectuó un muestreo mensual durante un año, usando el método de sustratos artificiales. Se identificaron 116 táxones pertenecientes a 47 familias y a 18 órdenes. La mayor abundancia se encontró en la clase Conchostraca y la familia Chironomidae que juntas representaron casi la mitad de todos los individuos colectados. En contraste, el 97% de los táxones tuvieron, cada uno, menos del 1% del total de la abundancia. La diversidad de táxones, así como la abundancia de individuos y el número de especies, fueron mayores en la época seca que en la lluviosa. La curva acumulada de especies indicó que se hubiera registrado una mayor cantidad de táxones si los muestreos se hubieran extendido por más tiempo. Con este trabajo damos a conocer la primera lista de macroinvertebrados para el humedal de Palo Verde.Benthic macroinvertebrates of the Palo Verde wetland, Costa Rica. Palo Verde, Costa Rica, is one of the most important wetlands in the region now recovering from some invasive plants, especially Typha domingensis, and monitoring programs were started, including studies on the aquatic macoinvertebrate fauna. We sampled benthic macroinvertebrates monthly for more than a year with artificial substrates, and identified 116 taxa from 57 families and 18 orders, with 90 morfospecies of insects. The highest abundances were in the class Conchostraca (typical in seasonal wetlands and in the family Chironomidae (Diptera, Insecta, which together represent almost half of all individuals collected. In contrast, 97 taxa were less than 1% of total abundance each. Number of individuals and number of

  19. Novel Thiol-Ene Hybrid Coating for Metal Protection

    Directory of Open Access Journals (Sweden)

    Mona Taghavikish

    2016-04-01

    Full Text Available A novel hybrid anticorrosion coating with dual network of inorganic (Si–O–Si and organic bonds (C–S–C was prepared on metal through an in situ sol-gel and thiol-ene click reaction. This novel interfacial thin film coating incorporates (3-mercaptopropyl trimethoxysilane (MPTS and 1,4-di(vinylimidazolium butane bisbromide based polymerizable ionic liquid (PIL to form a thiol-ene based photo-polymerized film, which on subsequent sol-gel reaction forms a thin hybrid interfacial layer on metal surface. On top of this PIL hybrid film, a self-assembled nanophase particle (SNAP coating was employed to prepare a multilayer thin film coating for better corrosion protection and barrier performance. The novel PIL hybrid film was characterised for structure and properties using Fourier transform infrared spectroscopy (FTIR, differential scanning calorimetry (DSC, and thermogravimetric analysis (TGA. The corrosion protection performance of the multilayer coating was examined using potentiodynamic polarization and electrochemical impedance spectroscopy (EIS. The results reveal that this novel double layer coating on metal offers excellent protection against corrosion and has remarkably improved the barrier effect of the coating.

  20. Metasedimentos siliciclásticos proterozoicos en la Sierra de Pie de Palo, San Juan: Procedencia y ambiente tectónico Proterozoic Siliciclastic metasediments in Sierra de Pie de Palo, San Juan: Provenance and tectonic setting

    OpenAIRE

    GI Vujovich

    2003-01-01

    Los metasedimentos del Grupo Caucete aflorantes en la sierra de Pie de Palo constituyen una pieza importante para entender la evolución del margen gondwánico durante el Proterozoico tardío a Paleozoico temprano. Esta secuencia metamórfica está en contacto tectónico, a través del Corrimiento Las Pirquitas, con el Complejo Pie de Palo (Mesoproterozoico). El Grupo Caucete está integrado por dos unidades mayores, una siliciclástica y otra carbonática, y basado en estudios de campo entre las quebr...

  1. Macroinvertebrados bentónicos del humedal de Palo Verde, Costa Rica

    Directory of Open Access Journals (Sweden)

    F.A Trama

    2009-11-01

    Full Text Available El humedal de Palo Verde es uno de los más importantes de Centro America para aves acuáticas. Durante el período 2002 y 2005, se llevaron a cabo actividades de manejo para controlar la invasión de Typha domingensis. Con el fin de establecer una línea base para monitoreos futuros, en el 2003 se realizó una evaluación de macroinvertebrados acuáticos. Se efectuó un muestreo mensual durante un año, usando el método de sustratos artificiales. Se identificaron 116 táxones pertenecientes a 47 familias y a 18 órdenes. La mayor abundancia se encontró en la clase Conchostraca y la familia Chironomidae que juntas representaron casi la mitad de todos los individuos colectados. En contraste, el 97% de los táxones tuvieron, cada uno, menos del 1% del total de la abundancia. La diversidad de táxones, así como la abundancia de individuos y el número de especies, fueron mayores en la época seca que en la lluviosa. La curva acumulada de especies indicó que se hubiera registrado una mayor cantidad de táxones si los muestreos se hubieran extendido por más tiempo. Con este trabajo damos a conocer la primera lista de macroinvertebrados para el humedal de Palo Verde.

  2. Development of robots for rehabilitation therapy: the Palo Alto VA/Stanford experience.

    Science.gov (United States)

    Burgar, C G; Lum, P S; Shor, P C; Machiel Van der Loos, H F

    2000-01-01

    For over 25 years, personal assistant robots for severely disabled individuals have been in development. More recently, using robots to deliver rehabilitation therapy has been proposed. This paper summarizes the development and clinical testing of three mechatronic systems for post-stroke therapy conducted at the VA Palo Alto in collaboration with Stanford University. We describe the philosophy and experiences that guided their evolution. Unique to the Palo Alto approach is provision for bimanual, mirror-image, patient-controlled therapeutic exercise. Proof-of-concept was established with a 2-degree-of-freedom (DOF) elbow/forearm manipulator. Tests of a second-generation therapy robot producing planar forearm movements in 19 hemiplegic and control subjects confirmed the validity and reliability of interaction forces during mechanically assisted upper-limb movements. Clinical trials comparing 3-D robot-assisted therapy to traditional therapy in 21 chronic stroke subjects showed significant improvement in the Fugl-Meyer (FM) measure of motor recovery in the robot group, which exceeded improvements in the control group.

  3. Tetramethyl-1-silacycloprop-2-ene: its characterization and reactions

    Energy Technology Data Exchange (ETDEWEB)

    Cornett, B.J.

    1980-05-01

    The object of this research is to fully characterize and study some of the reactions of tetramethyl-1-silacycloprop-2-ene. The final characterization of this compound was accomplished by obtaining both Si29 and 13C nuclear magnetic resonance spectra. The reactions studied included those with fluorenone, acetone, styrene, phenylacetylene, acetonitrile, t-butylcyanide, methyl isocyanate, phenyl azide, and azobenzene. Product analyses suggest that aside from addition reactions tetramethylsilacyclopropene can react either via a radical chain polymerization or an anionic chain polymerization mechanism with the latter being the more prevalent. Other reactions studied included the photolysis of tetramethylsilacyclopropene and its reactions in the presence of Pd(PPh/sub 3/)/sub 2/Cl/sub 2/. An appendix includes a study of trimethylsilyl radical disproportionation in the liquid phase to a sila olefin. Trimethylsilyl radicals in solution undergo disproportionation as well as recombination in a 1:5 ratio. The sila olefin formed by disproportionation was trapped by alcohols.

  4. 75 FR 15745 - Arizona Public Service Company, et al. Palo Verde Nuclear Generating Station, Units 1, 2, and 3...

    Science.gov (United States)

    2010-03-30

    ... COMMISSION Arizona Public Service Company, et al. Palo Verde Nuclear Generating Station, Units 1, 2, and 3; Exemption 1.0 Background The Arizona Public Service Company (APS, the licensee) is the holder of Facility... portions of the letters are being withheld from public disclosure. The licensee has requested an exemption...

  5. 75 FR 13606 - Arizona Public Service Company, Palo Verde Nuclear Generating Station, Units 1, 2, and 3...

    Science.gov (United States)

    2010-03-22

    ... COMMISSION Arizona Public Service Company, Palo Verde Nuclear Generating Station, Units 1, 2, and 3...-51, and NPF-74, issued to Arizona Public Service Company (APS, the licensee), for operation of the...-related information and, accordingly, those portions of the letters are being withheld from public...

  6. Structural evolution of a composite middle to lower crustal section: The Sierra de Pie de Palo, northwest Argentina

    Science.gov (United States)

    Mulcahy, S. R.; Roeske, S. M.; McClelland, W. C.; Jourdan, F.; Iriondo, A.; Renne, P. R.; Vervoort, J. D.; Vujovich, G. I.

    2011-02-01

    The Sierra de Pie de Palo of northwest Argentina preserves middle to lower crustal metamorphic rocks that were penetratively deformed during Ordovician accretion of the Precordillera terrane to the Gondwana margin. New structural, petrologic, and geochronologic data from a 40 km structural transect reveals that the Sierra de Pie de Palo preserves a middle to lower crustal ductile thrust complex consisting of individual structural units and not an intact ophiolite and cover sequence. Top-to-the-west thrusting occurred intermittently on discrete ductile shear zones from ˜515 to ˜417 Ma and generally propagated toward the foreland with progressive deformation. Ordovician crustal shortening and peak metamorphic temperatures in the central portion of the Sierra de Pie de Palo were synchronous with retro-arc shortening and magmatic flare-up within the Famatina arc. Accretion of the Precordillera terrane resulted in the end of arc flare-up and the onset of synconvergent extension by ˜439 Ma. Continued synextensional to postextensional convergence was accommodated along progressively lower grade shear zones following terrane accretion and the establishment of a new plate margin west of the Precordillera terrane. The results support models of Cordilleran orogens that link voluminous arc magmatism to periods of regional shortening. The deformation, metamorphic, and magmatic history within the Sierra de Pie de Palo is consistent with models placing the region adjacent to the Famatina margin in the middle Cambrian and not as basement to the Precordillera terrane.

  7. Community Youth Engagement in East Palo Alto: A Study of the Youth Arts and Music Center Initiative

    Science.gov (United States)

    Henderson, Jamila; Biscocho, Francine; Gerstein, Amy

    2016-01-01

    The Youth Arts and Music Center Initiative is a community-wide effort to design and build an arts center in East Palo Alto. The six-year process, supported by the Goldman Foundation, centered on youth leadership and the arts, and engaged a cross-sector collaborative of partner organizations in an attempt to address the city's shortage of existing…

  8. El deslizamiento de Palo Alto, Turrialba, Costa Rica : apuntes para su estudio

    Directory of Open Access Journals (Sweden)

    Peraldo Huertas, Giovanni

    2015-12-01

    Full Text Available En este trabajo se busca caracterizar, desde un punto de vista geomorfológico y geológico, el deslizamiento de Palo Alto, en el contexto de los megaprocesos de inestabilidad de laderas presentes en las laderas del río Reventazón. El corredor del río Reventazón, entre Turrialba y Siquirres, muestra una serie de procesos complejos de remoción en masa, que generan morfologías típicas de procesos de deslizamiento, tan continuas que dan una apariencia morfológica caótica, donde es difícil definir patrones de movimiento del terreno. El área de inestabilidad de Palo Alto se reconoce fácilmente incluso en el mapa topográfico correspondiente a escala 1:50 000, pues muestra una típica forma en herradura. Los límites del deslizamiento están bien marcados mediante escarpes bien definidos en campo, pero los extremos de las coronas laterales hacia el oeste se desdibujan debido, entre otras cosas, a que en esos sectores queda indefinido el límite al norte con el área de inestabilidad compleja de Bonilla y al sur con el área similar de Guayabo - Lajas. Se efectuó una fotointerpretación del área de estudio, mediante la revisión de fotos aéreas de la línea de vuelo Orosi-Pejibaye, escala 1:20 000 del año 1988, así como fotografías aéreas del proyecto Terra 1998, con el fin de observar posibles cambios en los procesos erosivos, así como en la forma del deslizamiento. Posteriormente, se realizó trabajo de campo para revisar la morfología fotointerpretada, analizar la conformación geológica a nivel de litología y estructura y así afinar la interpretación final de la geomorfología del área inestable de Palo Alto. Desde un punto de vista geológico, el área de estudio está compuesta por rocas sedimentarias del Neógeno, tales como la Fm. Uscari (Mioceno y las formaciones Suretka y Fm. Doán (Plioceno; además de aglomerados que posiblemente se relacionan al volcanismo holoceno de la cordillera volcánica Central. Mediante an

  9. Surface functionalized thiol-ene waveguides for fluorescence biosensing in microfluidic devices

    DEFF Research Database (Denmark)

    Feidenhans'l, Nikolaj Agentoft; Lafleur, Josiane P.; Jensen, Thomas Glasdam

    2013-01-01

    Thiol-ene polymers possess physical, optical, and chemical characteristics thatmake them ideal substrates for the fabrication of optofluidic devices. In this work, thiol-ene polymers are used to simultaneously create microfluidic channels and optical waveguides in one simple moulding step....... The reactive functional groups present at the surface of the thiol-ene polymer are subsequently used for the rapid, one step, site-specific functionalization of the waveguide with biological recognition molecules. It was found that while the bulk properties and chemical surface properties of thiol...... to conjugation with fluorescently labeled streptavidin. Fluorescence excitation was achieved by launching light through the thiol-ene waveguide, revealing bright fluorescent patterns along the channel/waveguide interface...

  10. Kas on plaanis tõsta lasteaia kohatasu? / Jekaterina Kuru, Rain Sangernebo, Ene Tigas ... [jt.

    Index Scriptorium Estoniae

    2011-01-01

    Küsimusele vastasid Audru lasteaia direktor Jekaterina Kuru, Nõo vallavanem Rain Sangernebo, Põlva Lepatriinu lasteaia direktor Ene Tigas, Juuru vallavalitsuse arendus- ja kultuurispetsialist Aili Normak, Alu lasteaia-algkooli direktor Ülle Riisalu

  11. Composition of fluid inclusions in Permian salt beds, Palo Duro Basin, Texas, U.S.A.

    Science.gov (United States)

    Roedder, E.; d'Angelo, W. M.; Dorrzapf, A.F.; Aruscavage, P. J.

    1987-01-01

    Several methods have been developed and used to extract and chemically analyze the two major types of fluid inclusions in bedded salt from the Palo Duro Basin, Texas. Data on the ratio K: Ca: Mg were obtained on a few of the clouds of tiny inclusions in "chevron" salt, representing the brines from which the salt originally crystallized. Much more complete quantitative data (Na, K, Ca, Mg, Sr, Cl, SO4 and Br) were obtained on ??? 120 individual "large" (mostly ???500 ??m on an edge, i.e., ??? ??? 1.6 ?? 10-4 g) inclusions in recrystallized salt. These latter fluids have a wide range of compositions, even in a given piece of core, indicating that fluids of grossly different composition were present in these salt beds during the several (?) stages of recrystallization. The analytical results indicating very large inter-and intra-sample chemical variation verify the conclusion reached earlier, from petrography and microthermometry, that the inclusion fluids in salt and their solutes are generally polygenetic. The diversity in composition stems from the combination of a variety of sources for the fluids (Permian sea, meteoric, and groundwater, as well as later migrating ground-, formation, or meteoric waters of unknown age), and a variety of subsequent geochemical processes of dissolution, precipitation and rock-water interaction. The compositional data are frequently ambiguous but do provide constraints and may eventually yield a coherent history of the events that produced these beds. Such an understanding of the past history of the evaporite sequence of the Palo Duro Basin should help in predicting the future role of the fluids in the salt if a nuclear waste repository is sited there. ?? 1987.

  12. Heavy minerals from the Palos Verdes Margin, Southern California: data and actor analysis

    Science.gov (United States)

    Wong, Florence L.

    2001-01-01

    Heavy or high-density minerals in the 63-250-_m (micron) size fraction (very fine and fine sand) were analyzed from 36 beach and offshore sites (38 samples) of the Palos Verdes margin to determine the areal and temporal mineralogic distributions and the relation of those distributions to the deposit affected by material discharged from the Los Angeles County Sanitation District sewage system (Lee, 1994) (Figure 1). Data presented here were tabulated for a report to the Department of Justice (Wong, 1994). The results of the data analysis are discussed in Wong (in press). The study of heavy minerals is a common method of determining sources (provenance) and distributions of sediments (e.g., Van Andel and Poole, 1960). The choice of grain size is governed by ease of sample preparation, examination by optical microscopy, and comparability to previous studies. How representative the 63-250-_m heavy minerals are of the whole sample can be approximated by the amount of sand in the sample. Lee and others (1994) mapped a pre-effluent, effluent-affected, and surface layer in the study area off Palos Verdes. The amount of sand in the top and pre-effluent layers ranges from about 20 to 80 percent; in the middle of the effluent body, sand is less than 20 percent (Figure 2; MacArthur and others, 1994). Qualitatively, the 63-250-_m heavy minerals are more representative of the top and pre-effluent layer, but these minerals will also provide useful information about the middle layer.

  13. Evapotranspiration estimates using remote-sensing data, Parker and Palo Verde valleys, Arizona and California

    Science.gov (United States)

    Raymond, Lee H.; Rezin, Kelly V.

    1989-01-01

    In 1981 the U.S. Geological Survey established an experimental project to assess the possible and practical use of remote-sensing data to estimate evapotranspiration as an approximation of consumptive use of water in the lower Colorado River flood plain. The project area was in Parker Valley, Arizona. The approach selected was to measure the areas covered by each type of vegetation, using remote-sensing data in various types of analyses, and to multiply each area by a predetermined water-use rate. Two calibration and six remote-sensing methods of classifying crop types were compared for cost, accuracy, consistency, and labor requirements. Included were one method each for field reconnaissance using 1982 data, low-altitude (less than 5,000 feet) aerial photography using 1982 data, and visual photointerpretation of Landsat satellite images using 1981 and 1982 data; two methods for medium-altitude (15,000-18,000 feet) aerial photography using 1982 data; and three methods for digital Landsat satellite images using 1981 data. A test of the most promising digital-processing method, which used three image dates, was made in part of Palo Verde Valley, California, where 1981 crop data were more complete than in Parker Valley. Of the eight methods studied, the two-date digital-processing method was the most consistent and least labor intensive for identifying two or three major crops; visual photointerpretation of Landsat images was the least expensive. Evapotranspiration estimates from crop classifications by all methods differed by a maximum of 6 percent. Total evapotranspiration calculated from crop data and phreatophyte maps in 1981 ranged from 11 percent lower in Palo Verde Valley to 17 percent lower in Parker Valley than consumptive use calculated by water budgets. The difference was greater in Parker Valley because the winter crop data were not included.

  14. Geostatistical mapping of effluent-affected sediment distribution on the Palos Verdes shelf

    Science.gov (United States)

    Murray, C. J.; Lee, H. J.; Hampton, M. A.

    2002-05-01

    Geostatistical techniques were used to study the spatial continuity of the thickness of effluent-affected sediment in the offshore Palos Verdes Margin area. The thickness data were measured directly from cores and indirectly from high-frequency subbottom profiles collected over the Palos Verdes Margin. Strong spatial continuity of the sediment thickness data was identified, with a maximum range of correlation in excess of 1.4 km. The spatial correlation showed a marked anisotropy, and was more than twice as continuous in the alongshore direction as in the cross-shelf direction. Sequential indicator simulation employing models fit to the thickness data variograms was used to map the distribution of the sediment, and to quantify the uncertainty in those estimates. A strong correlation between sediment thickness data and measurements of the mass of the contaminant p, p'-DDE per unit area was identified. A calibration based on the bivariate distribution of the thickness and p, p'-DDE data was applied using Markov-Bayes indicator simulation to extend the geostatistical study and map the contamination levels in the sediment. Integrating the map grids produced by the geostatistical study of the two variables indicated that 7.8 million m 3 of effluent-affected sediment exist in the map area, containing approximately 61-72 Mg (metric tons) of p, p'-DDE. Most of the contaminated sediment (about 85% of the sediment and 89% of the p, p'-DDE) occurs in water depths areas where the contaminated sediment is most prevalent.

  15. Redox Mediators in Visible Light Photocatalysis: Photocatalytic Radical Thiol?Ene Additions

    OpenAIRE

    Tyson, Elizabeth L.; Niemeyer, Zachary L.; Yoon, Tehshik P.

    2014-01-01

    Synthetically useful radical thiol?ene reactions can be initiated by visible light irradiation in the presence of transition metal polypyridyl photocatalysts. The success of this method relies upon the use of p-toluidine as an essential additive. Using these conditions, high-yielding thiol?ene reactions of cysteine-containing biomolecules can be accomplished using biocompatibile wavelengths of visible light, under aqueous conditions, and with the thiol component as the limiting reagent. We pr...

  16. Rapid photochemical surface patterning of proteins in thiol-ene based microfluidic devices

    DEFF Research Database (Denmark)

    Lafleur, Josiane P.; Kwapiszewski, Radoslaw; Jensen, Thomas G.

    2012-01-01

    The ability to immobilize biomolecules at specific locations on the surface of solid supports is central to many biochip applications. This paper reports the rapid one-step photochemical surface patterning of biomolecules in thiol-ene microfluidic chips. Adjusting the stoichiometric ratio of "thi...... photolithography. We also present quantitative data on the number of functional groups available for surface modification on thiol-ene substrates and their stability....

  17. Combined bead polymerization and Cinchona organocatalyst immobilization by thiol–ene addition

    Directory of Open Access Journals (Sweden)

    Kim A. Fredriksen

    2012-07-01

    Full Text Available In this work, we report an unusually concise immobilization of Cinchona organocatalysts using thiol–ene chemistry, in which catalyst immobilization and bead polymerization is combined in a single step. A solution of azo initiator, polyfunctional thiol, polyfunctional alkene and an unmodified Cinchona-derived organocatalyst in a solvent is suspended in water and copolymerized on heating by thiol–ene additions. The resultant spherical and gel-type polymer beads have been evaluated as organocatalysts in catalytic asymmetric transformations.

  18. Combined bead polymerization and Cinchona organocatalyst immobilization by thiol-ene addition.

    Science.gov (United States)

    Fredriksen, Kim A; Kristensen, Tor E; Hansen, Tore

    2012-01-01

    In this work, we report an unusually concise immobilization of Cinchona organocatalysts using thiol-ene chemistry, in which catalyst immobilization and bead polymerization is combined in a single step. A solution of azo initiator, polyfunctional thiol, polyfunctional alkene and an unmodified Cinchona-derived organocatalyst in a solvent is suspended in water and copolymerized on heating by thiol-ene additions. The resultant spherical and gel-type polymer beads have been evaluated as organocatalysts in catalytic asymmetric transformations.

  19. Draama 2007. Töörahu / Ene Paaver

    Index Scriptorium Estoniae

    Paaver, Ene, 1963-

    2008-01-01

    Ülevaade 2007. aasta eesti draamast. Pikemalt käsitletakse järgmisi autoreid ja nende näidendeid: Mart Kivastik "Tõnu võitlused", Mart Kivastik "Eesti asi", Mart Kivastik "Sõdur", Mart Kivastik "Kuninga viimane lahing ja ülikooli algus", Mart Kivastik, "Nokia 3310", Andrus Kivirähk "Voldemar", Andrus Kivirähk "Uljas neitsi", Hendrik Toompere "Kommunisti surm", Andres Ehin "Saatuslik kihlvedu ehk Volquin Varbola all", Jan Rahman "Jõujaam", Jaak Kõdar "Muinassaar", Karl Berg "Teekond valguse riiki", Angela Randmets "Lembelood vanas linnas", Toomas Kall "Tähtede sadu", Lauri Vahtre "Muna EÜE", Urmas Espenberg "Kestvad kiiduavaldused", Kalju Saaber "Koduvõõrad", Indrek Hirv "Pauluse kiriku kellad", Katrin Saukas "Võlg", Heidi Sarapuu "Austatud Riigikogu liikmed!", Heidi Sarapuu "Helisev viis", Heidi Sarapuu "Ankur hiivata", Jakob Karu "Vanaema juures", Jim Ashilevi "Nagu poisid vihma käes", Jim Ashilevi "Portselansuits", Eva Koff "Mirr", Jaak Prints "Karaoke", Kati Murutar "Mina, naine!", Ott Aardam "Börs ja Börsitar", Andrus Kivirähk, Jan Rahman, Contra "Kõrts", Mart Kase "Perekond", Villu Tamme "Haned võlgu"; Tiit Ojasoo ja Ene-Liis Semperi "GEP ehk Gorjatshije estonskije parni"

  20. Preparation and Preliminary Dielectric Characterization of Structured C60-Thiol-Ene Polymer Nanocomposites Assembled Using the Thiol-Ene Click Reaction

    Directory of Open Access Journals (Sweden)

    Hanaa M. Ahmed

    2015-11-01

    Full Text Available Fullerene-containing materials have the ability to store and release electrical energy. Therefore, fullerenes may ultimately find use in high-voltage equipment devices or as super capacitors for high electric energy storage due to this ease of manipulating their excellent dielectric properties and their high volume resistivity. A series of structured fullerene (C60 polymer nanocomposites were assembled using the thiol-ene click reaction, between alkyl thiols and allyl functionalized C60 derivatives. The resulting high-density C60-urethane-thiol-ene (C60-Thiol-Ene networks possessed excellent mechanical properties. These novel networks were characterized using standard techniques, including infrared spectroscopy (FTIR, differential scanning calorimetry (DSC, dynamic mechanical analysis (DMA, and thermal gravimetric analysis (TGA. The dielectric spectra for the prepared samples were determined over a broad frequency range at room temperature using a broadband dielectric spectrometer and a semiconductor characterization system. The changes in thermo-mechanical and electrical properties of these novel fullerene-thiol-ene composite films were measured as a function of the C60 content, and samples characterized by high dielectric permittivity and low dielectric loss were produced. In this process, variations in chemical composition of the networks were correlated to performance characteristics.

  1. Ene-Liis Semper : hindan päeva, kui teen ühte asja / Ene-Liis Semper ; interv. Jaanus Kulli

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2008-01-01

    Teatri- ja videokunstnik Ene-Liis Semper oma elust ja tööst. Lisaks repliik "Parim päev on tööst prii päev" ja peagi Teater NO99s esietenduvast William Shakespeare'i lavastusest "Muinasjutuline "Perikles"

  2. Simple preparation of thiol-ene particles in glycerol and surface functionalization by thiol-ene chemistry (TEC) and surface chain transfer free radical polymerization (SCT-FRP)

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Chiaula, Valeria; Pinelo, Manuel

    2017-01-01

    Thiol-ene (TE) based polymer particles have traditionally been prepared via emulsion polymerization in water (using surfactants, stabilizers and co-solvents). Here, we present a green and simple alternative with excellent control over particle size, while avoiding the addition of stabilizers...

  3. Simple preparation of thiol-ene particles in glycerol and surface functionalization by thiol-ene chemistry (TEC) and surface chain transfer free radical polymerization (SCT-FRP)

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Chiaula, Valeria; Pinelo, Manuel

    2017-01-01

    functionalization of excess thiol groups via photochemical thiol-ene chemistry (TEC) resulting in a functional monolayer. In addition, surface chain transfer free radical polymerization (SCT-FRP) was used for the first time to introduce a thicker polymer layer on the particle surface. The application potential...

  4. Functionalization of embedded thiol-ene waveguides for evanescent wave induced fluorescence detection in a microfluidic device

    DEFF Research Database (Denmark)

    Feidenhans'l, Nikolaj Agentoft; Jensen, Thomas Glasdam; Lafleur, Josiane P.

    2013-01-01

    We demonstrate the use of functional surface groups inherently present on off-stoichiometric thiol−ene polymers, for site-specific immobilization of biomolecules and detection by evanescent wave-induced fluorescence. An optofluidic chip featuring an embedded thiol−ene waveguide was selectively...... functionalized with biotin using photografting. The biotin was used for immobilization of fluorescently labelled streptavidin, and experiments revealed a linear correlation between streptavidin concentration and fluorescent intensity. To further demonstrate the attractiveness of using thiol−ene for optofluidic...... devices, the optical properties of thiol−ene was evaluated by determining the transparency and refractive index of the cured polymer....

  5. Functionalization of embedded thiol-ene waveguides for evanescent wave-induced fluorescence detection in a microfluidic device

    DEFF Research Database (Denmark)

    Feidenhans, Nikolaj A.; Jensen, Thomas Glasdam; Lafleur, Josiane P.

    2013-01-01

    We demonstrate the use of functional surface groups inherently present on off-stoichiometric thiol-ene polymers, for site-specific immobilization of biomolecules and detection by evanescent wave-induced fluorescence. An optofluidic chip featuring an embedded thiol-ene waveguide was selectively...... functionalized with biotin using photografting. The biotin was used for immobilization of fluorescently labelled streptavidin, and experiments revealed a linear correlation between streptavidin concentration and fluorescent intensity. To further demonstrate the attractiveness of using thiol-ene for optofluidic...... devices, the optical properties of thiol-ene was evaluated by determining the transparency and refractive index of the cured polymer....

  6. Physical and chemical effects of grain aggregates on the Palos Verdes margin, southern California

    Science.gov (United States)

    Drake, D.E.; Eganhouse, R.; McArthur, W.

    2002-01-01

    Large discharges of wastewater and particulate matter from the outfalls of the Los Angeles County Sanitation Districts onto the Palos Verdes shelf since 1937 have produced an effluent-affected sediment deposit characterized by low bulk density, elevated organic matter content, and a high percentage of fine silt and clay particles relative to underlying native sands and sandy silts. Comparison of the results of grain-size analyses using a gentle wet-sieving technique that preserves certain grain aggregates to the results of standard size analyses of disaggregated particles shows that high percentages (up to 50%) of the silt and clay fractions of the effluent-affected mud are incorporated in aggregates having intermediate diameters in the fine-to-medium sand size range (63-500 ??m), Scanning electron microscope images of the aggregates show that they are predominantly oval fecal pellets or irregularly shaped fragments of pellets. Deposit-feeding polychaete worms such as Capitella sp. and Mediomastus sp., abundant in the mud-rich effluent-affected sediment on Palos Verdes shelf, are probably responsible for most of the grain aggregates through fecal pellet production. Particle settling rates and densities, and the concentrations of organic carbon and p,p???-DDE, a metabolite of the hydrophobic pesticide DDT, were determined for seven grain-size fractions in the effluent-affected sediment. Fecal pellet grain densities ranged from about 1.2 to 1.5 g/cc, and their average settling rates were reduced to the equivalent of about one phi size relative to spherical quartz grains of the same diameter. However, repackaging of fine silt and clay grains into the sand-sized fecal pellets causes an effective settling rate increase of up to 3 orders of magnitude for the smallest particles incorporated in the pellets. Moreover, organic carbon and p,p???-DDE exhibit a bimodal distribution with relatively high concentrations in the finest size fraction (0-20 ??m), as expected, and a

  7. Seafloor mapping of the southeast Iberian margin (from Cabo de Palos to Cabo de Gata)

    Science.gov (United States)

    Lastras, Galderic; Leon, César; Elvira, Elena; Pascual, Laura; Muñoz, Araceli; de Cárdenas, Enrique; Acosta, Juan; Canals, Miquel

    2014-05-01

    We present the multibeam bathymetry and derived maps of the southeast Iberian margin from Cabo de Palos to Cabo de Gata, 37º35'N to 35º45'N and 2º10'W to 0º20'E, from the coastline down to the Algero-Balearic abyssal plain at depths exceeding 2600 m. The edition of of the maps is carried out within the Complementary Action VALORPLAT ("Scientific valorisation of multibeam bathymetry data from the Spanish continental shelf and slope"), funded by the Spanish Ministry of Economy and Competitivity. The multibeam bathymetry data of the slope and abyssal plain were obtained during different surveys in 2004, 2006 and 2007 on board R/V Vizconde de Eza with a Simrad EM300 multibeam echo-sounder as part of the CAPESME Project, a collaboration between the Spanish Institute of Oceanography (IEO) and General Secretariat of Fisheries (SGP), primarily aiming at creating maps of the fishing grounds of the Mediterranean continental margins of Spain. Multibeam bathymetry data from the continental shelf were obtained within the ESPACE project, also in a cooperative frame between IEO and SGP. The map series is constituted by a general map at 1:400,000 scale and 14 detailed maps at 1:75,000 scale, which include inset maps on slope gradients and seafloor nature (rock or sediment type), the later obtained with rock dredges and Shipeck sediment dredges. Both the detailed maps and the general map are available in paper print, and the whole collection is also distributed in an edited USB. The geological features displayed in the different maps include the continental shelf, with abundant geomorphic features indicative of past sea-level changes, the continental slope carved by the Palos, Tiñoso, Cartagena Este, Cartagena Oeste, Águilas, Almanzora, Alias, Garrucha and Gata submarine canyons, the Mazarrón, Palomares and Al-Mansour escarpments, the Abubácer, Maimonides and Yusuf ridges, the Águilas and Al-Mansour seamounts, and the Algero-Balearic abyssal plain where prominent

  8. Development and Testing of a Detector to Study Neutrino Oscillations at Palo Verde

    Science.gov (United States)

    Cook, Brian M.

    A detector for the study of neutrino oscillations with a projected sensitivity to Delta m^2 of 10^{-3} eV ^2 and to sin^2 2theta of 0.1 is described. It is to be installed 800 m from three pressurized water reactors at the Palo Verde Nuclear Generating Station near Phoenix, Arizona. The detector is segmented and filled with 12 tons of gadolinium-loaded liquid scintillator. It will be placed in an underground vault with an overburden of 46 mwe and surrounded by a 1-m-thick water buffer and a hermetic active muon veto. Reactor antineutrinos are detected through proton inverse beta decay in the hydrogen-rich scintillator, and the resulting positrons are discriminated from fast neutron background by requiring a prompt coincidence across several cells between the positron and its annihilation radiation. Test results from prototype detector elements are presented showing excellent stability of the scintillator and acrylic target cells. A method of calibrating the positron detection efficiency is described in detail, and results of a prototype experiment using a small-scale detector are presented. The results of a full-detector Monte Carlo simulation, based on the CERN and Oak Ridge packages GEANT and GCALOR, are discussed: anticipated backgrounds due to natural radioactivity and to fast neutrons are described in detail.

  9. Environmental review for Site A/Plot M, Palos Forest Preserve, Cook County, Illinois

    Energy Technology Data Exchange (ETDEWEB)

    Biang, R.P.; Yuen, C.R.; Avci, H.I.; Haffenden, R.

    1993-06-01

    This report is an environmental review of two sites known as Site A and Plot M, which are located in the Palos Forest Preserve of the Forest Preserve District of Cook County, approximately 20 mi southwest of downtown Chicago and about 3 mi east of the current site of Argonne National Laboratory (ANL). An enlarged map of the area around the sites is shown in a figure. Site A covers about 19 acres, and Plot M covers about 1 acre. This document consists of the following sections: a review of the site history and environment, a description of the conceptual pathway models for both Site A and Plot M and a brief discussion of previous sampling events, a discussion of possible transport pathways, an evaluation of the Phase 2 Work Plan for Site A, a review of the applicable or relevant and appropriate regulations (ARARs), and recommendations for future study. The recommendations are based on an evaluation of previously collected data. Where data were sufficient, a geologic conceptual model was developed. If data were not sufficient to develop a model, recommendations for data collection are made. A new base map was developed for the site by using the base survey conducted in the 1940s, aerial photographs dating back to 1948, and site visits.

  10. Surface modification of cyclomatrix polyphosphazene microsphere by thiol-ene chemistry and lectin recognition

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chen; Zhu, Xue-yan; Gao, Qiao-ling; Fang, Fei; Huang, Xiao-jun, E-mail: hxjzxh@zju.edu.cn

    2016-11-30

    Graphical abstract: A new synthetic route leading to polyphosphazene cyclomatrix microsphere with various functional groups has achieved via thiol-ene click modification. Herein, hexacholorocyclophosphazene (HCCP) crosslinked with bisphenol-S and 4,4′-diallyl bisphenol-S to generate broadly dispersed microspheres. Thiol-ene modification under UV irradiation not only presented high efficiency and flexibility for post-functionalization, but also imposed no harm on global morphology and crosslinked skeleton of such microspheres. - Highlights: • Functional polyphosphazene microspheres with high chemical flexibility were synthesized by thiol-ene modification. • Polyphosphazene microspheres possessed high thermal stability. • Glycosylated polyphosphazene microspheres showed affinity to lectin Con-A, which inferred potential application in biomedicine. - Abstract: A new synthetic route leading to functional polyphosphazene cyclomatrix microsphere has been developed via thiol-ene click modification. Hexacholorocyclophosphazene (HCCP) was crosslinked with both bisphenol-S and 4,4′-diallyl bisphenol-S to obtain vinyl polyphosphazene microspheres (VPZM) in order to ensure high crosslinking degree and introduce vinyl moieties. Compared to the microspheres obtained by HCCP and bisphenol-S, the size of VPZM was broadly dispersed from 400 nm to 1.40 μm. Thiol-ene click reactions were carried out to attach functional groups, such as glucosyl, carboxyl, ester and dodecyl groups onto polyphosphazene microspheres, which demonstrated no change in morphology and size after modification. Solid state NMR (SSNMR) and Fourier transform infrared spectoscopy (FT-IR) results showed that the vinyl moieties were introduced in the period of crosslinking and functionalization was also successful via click reactions. Moreover, the microspheres presented a little difference in thermal properties after modification. Concanavalin A (Con-A) fluorescent adsorption was also observed for

  11. Thiol-ene functionalized siloxanes for use as elastomeric dental impression materials.

    Science.gov (United States)

    Cole, Megan A; Jankousky, Katherine C; Bowman, Christopher N

    2014-04-01

    Thiol- and allyl-functionalized siloxane oligomers are synthesized and evaluated for use as a radical-mediated, rapid set elastomeric dental impression material. Thiol-ene siloxane formulations are crosslinked using a redox-initiated polymerization scheme, and the mechanical properties of the thiol-ene network are manipulated through the incorporation of varying degrees of plasticizer and kaolin filler. Formulations with medium and light body consistencies are further evaluated for their ability to accurately replicate features on both the gross and microscopic levels. We hypothesize that thiol-ene functionalized siloxane systems will exhibit faster setting times and greater detail reproduction than commercially available polyvinylsiloxane (PVS) materials of comparable consistencies. Thiol-ene functionalized siloxane mixtures formulated with varying levels of redox initiators, plasticizer, and kaolin filler are made and evaluated for their polymerization speed (FTIR), consistency (ISO4823.9.2), and surface energy (goniometer). Feature replication is evaluated quantitatively by SEM. The Tg, storage modulus, and creep behavior are determined by DMA. Increasing redox initiation rate increases the polymerization rate but at high levels also limits working time. Combining 0.86 wt% oxidizing agent with up to 5 wt% plasticizer gave a working time of 3 min and a setting time of 2 min. The selected medium and light body thiol-ene formulations also achieved greater qualitative detail reproduction than the commercial material and reproduced micrometer patterns with 98% accuracy. Improving detail reproduction and setting speed is a primary focus of dental impression material design and synthesis. Radical-mediated polymerizations, particularly thiol-ene reactions, are recognized for their speed, reduced shrinkage, and 'click' nature. Copyright © 2014 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  12. Rapid and simple preparation of thiol-ene emulsion-templated monoliths and their application as enzymatic microreactors

    DEFF Research Database (Denmark)

    Lafleur, Josiane P; Senkbeil, Silja; Novotny, Jakub

    2015-01-01

    electron microscopy showed that the methanol-based emulsion templating process resulted in a network of highly interconnected and regular thiol-ene beads anchored solidly inside thiol-ene microchannels. Surface area measurements indicate that the monoliths are macroporous, with no or little micro...

  13. Crosslinking and degradation of step-growth hydrogels formed by thiol-ene photo-click chemistry

    Science.gov (United States)

    Shih, Han; Lin, Chien-Chi

    2014-01-01

    Thiol-ene photo-click hydrogels have been used for a variety of tissue engineering and controlled release applications. In this step-growth photopolymerization scheme, multi-arm poly(ethylene glycol) norbornene (PEG4NB) was crosslinked with di-thiol containing crosslinkers to form chemically crosslinked hydrogels. While the mechanism of thiol-ene gelation was well described in the literature, its network ideality and degradation behaviors are not well-characterized. Here, we compared the network crosslinking of thiol-ene hydrogels to Michael-type addition hydrogels and found thiol-ene hydrogels formed with faster gel points and higher degree of crosslinking. However, thiol-ene hydrogels still contained significant network non-ideality, demonstrated by a high dependency of hydrogel swelling on macromer contents. In addition, the presence of ester bonds within the PEG-norbornene macromer rendered thiol-ene hydrogels hydrolytically degradable. Through validating model predictions with experimental results, we found that the hydrolytic degradation of thiol-ene hydrogels was not only governed by ester bond hydrolysis, but also affected by the degree of network crosslinking. In an attempt to manipulate network crosslinking and degradation of thiol-ene hydrogels, we incorporated peptide crosslinkers with different sequences and characterized the hydrolytic degradation of these PEG-peptide hydrogels. In addition, we incorporated a chymotrypsin-sensitive peptide as part of the crosslinkers to tune the mode of gel degradation from bulk degradation to surface erosion. PMID:22708824

  14. 3-(1H-Indol-3-yl-4-(morpholin-4-ylcyclobut-3-ene-1,2-dione

    Directory of Open Access Journals (Sweden)

    Johann Grünefeld

    2012-06-01

    Full Text Available 3-(1H-Indol-3-yl-4-(morpholin-4-ylcyclobut-3-ene-1,2-dione was obtained in good yields (72–82% by nucleophilic substitution of 3-chloro-4-(1H-indol-3-ylcyclobut-3-ene-1,2-dione with morpholine.

  15. Rapid photochemical surface patterning of proteins in thiol-ene based microfluidic devices

    DEFF Research Database (Denmark)

    Lafleur, Josiane P.; Kwapiszewski, Radoslaw; Jensen, Thomas Glasdam

    2013-01-01

    The suitable optical properties of thiol–ene polymers combined with the ease of modifying their surface for the attachment of recognition molecules make them ideal candidates in many biochip applications. This paper reports the rapid one-step photochemical surface patterning of biomolecules...... ! 17 SH nm"2. Biotin alkyne was patterned directly inside thiol–ene microchannels prior to conjugation with fluorescently labelled streptavidin. The surface bound conjugates were detected by evanescent waveinduced fluorescence (EWIF), demonstrating the success of the grafting procedure and its...... potential for biochip applications....

  16. Preparation and Characterization of Fluorinated Hydrophobic UV-Crosslinkable Thiol-Ene Polyurethane Coatings

    Directory of Open Access Journals (Sweden)

    Wenjing Xia

    2017-08-01

    Full Text Available The polyurethane prepolymer terminated with a double bond was synthesized using isophorone diisocyanate (IPDI, hydroxyl terminated polybutadiene (HTPB, 1,4-butanediol (BDO, and 2-hydroxyethyl acrylate (HEA. Then, a series of innovative UV-curable polyurethane coatings were prepared by blending ene-terminated polyurethane, fluoroacrylate monomer, and multifunctional thiol crosslinker upon UV exposure. The incorporation of fluoroacrylate monomer and multifunctional thiols into polyurethane coatings significantly enhanced the hydrophobic property, mechanical property, pencil hardness, and glossiness of the polyurethane coatings. This method of preparing UV crosslinkable, hydrophobic polyurethane coatings based on thiol-ene chemistry exhibited numerous advantages over other UV photocuring systems.

  17. Juegos de Palo en Lara. Elementos para la historia social de un arte marcial venezolano

    Directory of Open Access Journals (Sweden)

    Röhrig Assunção, Matthias

    1999-04-01

    Full Text Available This article situates Venezuelan stick fighting among the wider field of European and Afro-American martial arts. The author analyses the different forms used since the early 19th century by men in the rural areas of the state of Lara, where it is still practised today. Whereas the Juego de Garrote serves recreational and sportive purposes, the Juego de Batalla is part of a broader devotion to Saint Anthony. The criminal records show how the use of the fighting stick in the period 1880-1930 allowed the construction of a male identity (the «guapo» through the frequent fights between men.

    Este trabajo intenta situar a los juegos de palo venezolanos dentro de una perspectiva más amplia de las artes marciales europeas y afro-americanas. Analiza las diferentes modalidades practicadas desde el siglo XIX por los hombres del campo en Lara, Estado donde se conservó su práctica hasta hoy en día. Mientras el Juego de Garrote servía y sirve para fines recreativos y deportivos, el Juego de Batalla era y es parte de la devoción a San Antonio. Los procesos criminales muestran cómo el uso del garrote permitió la construcción de una identidad masculina («el guapo» a través de las frecuentes riñas entre hombres en el período 1880-1930.

  18. Comparison of estimates of evapotranspiration and consumptive use in Palo Verde Valley, California

    Science.gov (United States)

    Raymond, Lee H.; Owen-Joyce, Sandra J.

    1987-01-01

    Estimates of evapotranspiration and consumptive use by vegetation in Palo Verde Valley, California, were compared for calendar years 1981 to 1984. Vegetation types were classified, and the areas covered by each type were computed from Landsat satellite digital-image analysis. Evapotranspiration was calculated by multiplying the area of each vegetation type by a corresponding water use rate adjusted for year-to-year variations in climate. The vegetation classification slightly underestimates the total vegetated area when compared to crop reports, because not all multiple cropping could be identified. The accuracy of evapotranspiration calculated from vegetation classification depends primarily on the correct classification of alfalfa and cotton because alfalfa and cotton have larger acreages and use more water/acre than the other crops in the valley. Consumptive use was calculated using a water budget for each of the 4 years. Estimates of evapotranspiration and consumptive use by vegetation, respectively, were: (1) 439,400 and 483,500 acre-ft in 1981, (2) 430,700 and 452,700 acre-ft in 1982, (3) 402,000 and 364,400 acre-ft in 1983, and (4) 406,700 and 373,800 acre-ft in 1984. Evapotranspiration estimates were lower than consumptive use estimates in 1981 and 1982 and higher in 1983 and 1984. Both estimates were lower in 1983 and 1984 than in 1981 and 1982. Yearly differences in estimates correspond most closely to significant changes in stage of the lower Colorado River caused by flood control releases in 1983 and 1984 and to changes in cropping practices. (Author 's abstract)

  19. Mait Agu nimelise stipendiumi pälvivad aastal 2013 Eliisa Sokk ja Ene Jakobson

    Index Scriptorium Estoniae

    2013-01-01

    Tallinna Ülikooli koreograafia osakond annab Mait Agu nimelist stipendiumi välja viieteistkümnendat korda. Stipendiumi saavad TLÜ koreograafia osakonna 3. kursuse tudeng Eliisa Sokk ja TLÜ koreograafia eriala 2. lennu lõpetaja, tantsuansambli "Sõleke" looja ning juht Ene Jakobson

  20. Preparation of Biomolecule Microstructures and Microarrays by Thiol–ene Photoimmobilization

    NARCIS (Netherlands)

    Weinrich, Dirk; Köhn, Maja; Jonkheijm, Pascal; Westerlind, Ulrika; Dehmelt, Leif; Engelkamp, Hans; Christianen, Peter C.M.; Kuhlmann, Jürgen; Maan, Jan C.; Nüsse, Dirk; Schröder, Hendrik; Wacker, Ron; Voges, Edgar; Breinbauer, Rolf; Kunz, Horst; Niemeyer, Christof M.; Waldmann, Herbert

    2010-01-01

    A mild, fast and flexible method for photoimmobilization of biomolecules based on the light-initiated thiol–ene reaction has been developed. After investigation and optimization of various surface materials, surface chemistries and reaction parameters, microstructures and microarrays of biotin,

  1. Patterned Hydrophilization of Nanoporous 1,2‐PB by Thiol‐ene Photochemistry

    DEFF Research Database (Denmark)

    Berthold, Anton; Sagar, Kaushal Shashikant; Ndoni, Sokol

    2011-01-01

    is monitored by FT‐IR, UV–Vis, contact angle, and gravimetry. Overall quantum yields are calculated for the two thiol‐ene “click” reactions in nano‐confinement, neatly revealing their chain‐like nature. Top–down photolithographic patterning is demonstrated, realizing hydrophilic nanoporous “corridors...

  2. On-resin peptide macrocyclization using thiol-ene click chemistry

    OpenAIRE

    Aimetti, Alex A.; Shoemaker, Richard K.; Lin, Chien-Chi; Anseth, Kristi S

    2010-01-01

    A versatile and rapid synthetic strategy has been developed for the on-resin cyclization of peptides using thiol-ene photochemistry. This unique method exploits the thiol group of natural cysteine amino acids and allows for various alkenes to be incorporated orthogonal to the peptide backbone.

  3. Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis

    KAUST Repository

    Baumgartner, Corinne

    2010-01-01

    Our efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted S N2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention of stereochemistry. © 2010 The Royal Society of Chemistry.

  4. Functional monolayers on oxide-free silicon surfaces via thiol–ene click chemistry

    NARCIS (Netherlands)

    Caipa Campos, Mabel A.; Paulusse, Jos Marie Johannes; Zuilhof, Han

    2010-01-01

    Thiol–ene click chemistry was used for the attachment of a variety of functional molecules onto oxide-free Si(111) surfaces using very mild conditions; the efficient nature of this coupling strategy allowed for successful light-induced micropatterning and thus provides a novel route towards

  5. Development of Thermal and Photochemical Strategies for Thiol−Ene Click Polymer Functionalization

    NARCIS (Netherlands)

    Campos, Luis M.; Killops, Kato L.; Sakai, Ryosuke; Paulusse, Jos Marie Johannes; Damiron, Denis; Drockenmuller, Eric; Messmore, Benjamin W.; Hawker, Craig J.

    2008-01-01

    A series of alkene-functional polymers were synthesized by controlled polymerization techniques in order to investigate and compare the efficiency and orthogonality of both photochemically and thermally initiated thiol−ene click coupling reactions. The copolymers were designed to have single or

  6. DFT Investigation of the Palladium-Catalyzed Ene-Yne Coupling

    DEFF Research Database (Denmark)

    Henriksen, Signe Teuber; Tanner, David Ackland; Skrydstrup, T.

    2010-01-01

    ). Concerning chemoselectivity, the calculations also clarify why the ene-yne coupling is able to dominate over plausible alternative reaction pathways such as alkene homocoupiing and alkyne polymerization. The role of the phosphine ligand at various stages of the catalytic cycle has also been delineated....

  7. Electron swarm parameter measurements of perfluorobut-2-ene (2-C4F8)

    OpenAIRE

    Chachereau, Alise; Franck, Christian M.

    2015-01-01

    In this contribution, the electron swarm parameters of perfluorobut-2-ene (2-C4F8) mixtures with the buffer gases N2, CO2 and Argon are experimentally investigated. The effective ionization rate constant and electron drift velocity are measured in the entire E/N range up to the critical density-reduced electric field.

  8. Rapid photochemical surface patterning of proteins in thiol-ene based microfluidic devices

    DEFF Research Database (Denmark)

    Lafleur, Josiane P.; Kwapiszewski, Radoslaw; Jensen, Thomas Glasdam

    2012-01-01

    ” and “ene” monomers present in the microfluidic chip bulk material provides a simple and efficient way of tuning the chip’s surface chemistry. Here, thiol-ene chips displaying an excess of functional thiol groups at their surfaces are functionalized with biotin and streptavidin in a controlled fashion using...

  9. Metasedimentos siliciclásticos proterozoicos en la Sierra de Pie de Palo, San Juan: Procedencia y ambiente tectónico

    OpenAIRE

    GI Vujovich

    2003-01-01

    Los metasedimentos del Grupo Caucete aflorantes en la sierra de Pie de Palo constituyen una pieza importante para entender la evolución del margen gondwánico durante el Proterozoico tardío a Paleozoico temprano. Esta secuencia metamórfica está en contacto tectónico, a través del Corrimiento Las Pirquitas, con el Complejo Pie de Palo (Mesoproterozoico). El Grupo Caucete está integrado por dos unidades mayores, una siliciclástica y otra carbonática, y basado en estudios de campo entre las quebr...

  10. Helminth infracommunity structure of Leptodactylus melanonotus (Anura) in Tres Palos, Guerrero, and other records for this host species in Mexico.

    Science.gov (United States)

    Mata-López, Rosario; León-Règagnon, Virginia; García-Prieto, Luis

    2013-06-01

    The amphibian genus Leptodactylus includes around 50 species, of which only 2 are distributed in Mexico; the helminth fauna of these 2 species is poorly known. As part of a research program on amphibian parasites in Mexico from 1997 to 2005, 281 sabinal frogs Leptodactylus melanonotus from 42 localities in 11 Mexican states were examined from a helminthological perspective. A total of 20 taxa of helminths-7 digeneans (5 adults, 2 larvae) and 13 nematodes (8 adults, 5 larvae)-was found to infect this amphibian host species. These data represent 105 new locality records, and 11 taxa are recorded in L. melanonotus for the first time. Infracommunity analyses of the sabinal frogs from Tres Palos indicated that these hosts are depauperate. The helminth community is dominated by specialist species, with Cosmocerca podicipinus the most common in almost 50% of the infracommunities. Percutaneous infection and predator-prey interactions were the 2 most common infection routes by helminths in frogs from Tres Palos, with 79% of the parasites recruited via skin penetration. Finally, our results show that the helminth fauna parasitizing L. melanonotus throughout Mexico has low similarity with the helminth fauna of leptodactylids studied comprehensively in South America, with only 2 digeneans and 3 nematodes being shared by hosts from both regions. As a result of our survey, the number of helminth species parasitizing L. melanonotus increased to 34. Considering its native distribution range, this number is now 36 with the inclusion of the nematodes Oswaldocruzia costaricensis and Cruzia empera in Costa Rica.

  11. Reformatted data sets used in the Cooperative LACSD/USGS Palos Verdes Flow Study, 2000--2008

    Science.gov (United States)

    Anderson, Todd; Rosenberger, Kurt J.; Gartner, Anne L.

    2012-01-01

    Beginning in 1997, the Environmental Protection Agency (EPA) defined a contaminated section of the Palos Verdes shelf in southern California as a Superfund site, initiating a continuing investigation of this area. A number of agencies, including the EPA, U.S. Geological Survey (USGS), and Science Applications International Corporation (SAIC), conducted two oceanographic measurement programs in 2004 and 2007-2008 (SAIC, 2004, 2005; Rosenberger and others, 2010; Sherwood and others, unpublished data) to improve our understanding of the natural processes that resuspend and transport sediment in the area, especially in the region southeast of the Whites Point ocean outfall where earlier measurements were thought to be deficient. Los Angeles County Sanitation Districts (LACSD) deployed a simpler but much broader array of instruments on the Palos Verdes shelf and within the northern reaches of San Pedro Bay from 2000 to 2008 in order to characterize the current and temperature patterns within these regions. This program overlapped the two programs run by USGS and other agencies in 2004 and 2007. The LACSD data were made available to the USGS and the EPA in order to support their joint efforts to model the transport of the contaminated sediments in the region. This report describes the LACSD data sets, the instruments and data-processing procedures used, and the archive that contains the data sets that have passed our quality-assurance procedures.

  12. A Study of Functional Polymer Colloids Prepared Using Thiol-Ene/Yne Click Chemistry

    Science.gov (United States)

    Durham, Olivia Z.

    This project demonstrates the first instance of thiol-ene chemistry as the polymerization method for the production of polymer colloids in two-phase heterogeneous suspensions, miniemulsions, and emulsions. This work was also expanded to thiol-yne chemistry for the production of polymer particles containing increased crosslinking density. The utility of thiol-ene and thiol-yne chemistries for polymerization and polymer modification is well established in bulk systems. These reactions are considered 'click' reactions, which can be defined as processes that are both facile and simple, offering high yields with nearly 100% conversion, no side products, easy product separation, compatibility with a diverse variety of commercially available starting materials, and orthogonality with other chemistries. In addition, thiol-ene and thiol-yne chemistry follow a step-growth mechanism for the development of highly uniform polymer networks, where polymer growth is dependent on the coupling of functional groups. These step-growth polymerization systems are in stark contrast to the chain-growth mechanisms of acrylic and styrenic monomers that have dominated the field of conventional heterogeneous polymerizations. Preliminary studies evaluated the mechanism of particle production in suspension and miniemulsion systems. Monomer droplets were compared to the final polymer particles to confirm that particle growth occurred through the polymerization of monomer droplets. Additional parameters examined include homogenization energy (mechanical mixing), diluent species and concentration, and monomer content. These reactions were conducted using photoinitiation to yield particles in a matter of minutes with diameters in the size range of several microns to hundreds of microns in suspensions or submicron particles in miniemulsions. Improved control over the particle size and size distribution was examined through variation of reaction parameters. In addition, a method of seeded suspension

  13. An Alpine-style Ordovician collision complex in the Sierra de Pie de Palo, Argentina: Record of subduction of Cuyania beneath the Famatina arc

    Science.gov (United States)

    van Staal, C. R.; Vujovich, G. I.; Currie, K. L.; Naipauer, M.

    2011-03-01

    The Caucete Group and structurally overlying Pie de Palo Complex in western Argentina are characterised by two generations of west-verging folds and thrust-related shear zones, which formed under amphibolite facies conditions. The Caucete Group is separated from the Pie de Palo Complex by the Pirquitas thrust. These structures are interpreted to have formed as a result of a progressive deformation, generated during Middle Ordovician, underthrusting of the Laurentian-derived Cuyania microcontinent beneath the active Famatina margin. Geometrical relationships are most simply explained if the Pie de Palo Complex was basement to the Caucete Group prior to Ordovician orogenesis. We propose that this basement-cover relationship was established during Cambrian rifting of the Cuyania microcontinent from Laurentia. The Pirquitas fault may have been initiated during this extension prior to its long-lived remobilization as a thrust. We cannot rule out the possibility that the Pie de Palo Complex was exotic with respect to the Caucete Group, but for this to be possible we have to introduce an extra generation of structures, for which no evidence is preserved. The deformation was characterised by early strain localization followed by a more homogeneously distributed non-coaxial flow during F 2. Thermal softening probably dominated over fabric softening during this stage.

  14. Development of a thiol-ene based screening platform for enzyme immobilization demonstrated using horseradish peroxidase

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Pinelo, Manuel; Woodley, John

    2017-01-01

    functionalization by thiol-ene chemistry (TEC) resulted in the formation of a functional monolayer in each well, whereas, polymer surface grafts were introduced through surface chain transfer free radical polymerization (SCT-FRP). Enzyme immobilization on the modified surfaces was evaluated by using a rhodamine...... labeled horseradish peroxidase (Rho-HRP) as a model enzyme, and the amount of immobilized enzyme was qualitatively assessed by fluorescence intensity (FI) measurements. Subsequently, Rho-HRP activity was measured directly on the surface. The broad range of utilized surface chemistries permits direct...... correlation of enzymatic activity to the surface functionality and improves the determination of promising enzyme-surface candidates. The results underline the high potential of this system as a screening platform for synergistic immobilization of enzymes onto thiol-ene polymer surfaces. This article...

  15. Hybrid thiol-ene network nanocomposites based on multi(meth)acrylate POSS.

    Science.gov (United States)

    Li, Liguo; Liang, Rendong; Li, Yajie; Liu, Hongzhi; Feng, Shengyu

    2013-09-15

    First, multi(meth)acrylate functionalized POSS monomers were synthesized in this paper. Secondly, FTIR was used to evaluate the homopolymerization behaviors of multi(meth)acrylate POSS and their copolymerization behaviors in the thiol-ene reactions with octa(3-mercaptopropyl) POSS in the presence of photoinitiator. Results showed that the photopolymerization rate of multimethacrylate POSS was faster than that of multiacrylate POSS. The FTIR results also showed that the copolymerizations were dominant in the thiol-ene reactions with octa(3-mercaptopropyl) POSS, different from traditional (meth)acrylate-thiol system, in which homopolymerizations were predominant. Finally, the resulted hybrid networks based on POSS were characterized by XRD, FE-SEM, DSC, and TGA. The characterization results showed that hybrid networks based on POSS were homogeneous and exhibited high thermal stability. Copyright © 2013 Elsevier Inc. All rights reserved.

  16. Abundancia, diversidad y categoría ecológica de los peces en estero damas y estero palo seco, Costa Rica

    Directory of Open Access Journals (Sweden)

    Hubert Araya

    2016-03-01

    Full Text Available Se trabajó de junio de 1986 a febrero de 1987 en una estación de muestreo en el estero Palo Seco y en dos en el estero Damas (Damas y San Bosco, Pacífico Central, Costa Rica. La temperatura del agua no presentó diferencias significativas entre las estaciones Damas y San Bosco, pero sí entre Damas-Palo Seco y San Bosco-Palo Seco. La salinidad varió significativamente entre las tres estaciones y el pH no mostró diferencias significativas. Se recolectaron representantes de 25 familias, 39 géneros y 54 especies. De las especies, 18 comparten los tres sitios de muestreo, siete se hallaron únicamente en Palo Seco, cinco en Damas y seis en San Bosco. De las especies recolectadas, el 7,41% es compartido entre Palo Seco y Damas; el 3,70% entre Palo Seco y San Bosco y el 22,22% entre Damas y San Bosco. El análisis de similitud determinó que las estaciones Damas y San Bosco comparten un 41,40% de las especies; mientras que Palo Seco solamente presento un 9,9% de especies comunes con el grupo Damas-San Bosco. La mayoría de las especies encontradas fueron de origen marino que utilizan estos dos esteros como área de crianza (42,59% y alimentación (40,74%; mientras que las de agua dulce, estuarinas y visitantes ocasionales están poco representadas. La mayor diversidad se encontró en San Bosco y se detectaron diferencias estadísticamente significativas en los valores de H' entre las estaciones. La mayor similitud de especies se presentó entre las estaciones Damas y San Bosco, lo que sugiere que estas áreas están bajo una mayor influencia de aguas continentales; lo que propicia que los peces estén más ampliamente distribuidos. Se deduce que la ictiofauna de los esteros estudiados es transitoria en los sitios de muestreo y que la misma se distribuye heterogéneamente.

  17. Acyloxylation of 1-methoxycyclohex-1-ene and other enol ethers with dimethyl peroxydicarbonate

    OpenAIRE

    Schank, Kurt; Beck, Horst; Pistorius, Susanne; Rapold, Thomas

    1995-01-01

    Acyloxylation of different types of enol ethers (derived from aldehydes and ketones) by dimethyl peroxydicarbonate (DPDC) results in either addition to the double bond or in a formal replacement of an allylic hydrogen by a methoxycarbonyloxy group forming vicinal oxygenated hydrocarbons. 1,3-oxygenated products via monoacyloxylation could not be observed. The results with 1-methoxycyclohex-1-ene (1a) are compared with copper(I)-salt catalyzed acyloxylations by means of tert. butyl peroxycarbo...

  18. Heterofunctional Glycopolypeptides by Combination of Thiol-Ene Chemistry and NCA Polymerization.

    Science.gov (United States)

    Krannig, Kai-Steffen; Schlaad, Helmut

    2016-01-01

    Glycopolypeptides are prepared either by the polymerization of glycosylated amino acid N-carboxyanhydrides (NCAs) or by the post-polymerization functionalization of polypeptides with suitable functional groups. Here we present a method for the in-situ functionalization and (co-) polymerization of allylglycine N-carboxyanhydride in a facile one-pot procedure, combining radical thiol-ene photochemistry and nucleophilic ring-opening polymerization techniques, to yield well-defined heterofunctional glycopolypeptides.

  19. Ene-Liis Semper : Kohalolu piiritsoonis = Presence in the border zone / Anu Allas

    Index Scriptorium Estoniae

    Allas, Anu, 1977-

    2007-01-01

    Teatri- ja videokunstnik Ene-Liis Semperi peamiselt 1990-ndate aastate videotest, mis on valdavalt rõhutatult lavastuslikud, paisutatult sümbolistlikud või kus on esitatud piirsituatsioone, ahistust ning selle teadlikku eksponeerimist väljakutsena publikule. Iseennast paljastades, alandades ja ohtu seades jääb kunstnik enamasti jahedalt distantseerituks, publikule jääb aga arusaamatuks, kas tegemist on ohvri, kangelanna või osava mänguriga

  20. One-pot, additive-free preparation of functionalized polyurethanes via amine-thiol-ene conjugation

    OpenAIRE

    Espeel, Pieter; Goethals, Fabienne; Driessen, Frank; Nguyen, Le Thu Thi; Du Prez, Filip

    2013-01-01

    A straightforward, isocyanate-free method for the synthesis of functionalized polyurethanes, based on amine-thiol-ene conjugation, was elaborated. Aminolysis of a readily available AB'-urethane monomer, containing both an acrylate (A) and a thiolactone unit (B'), facilitates the preparation of various reactive thiol-acrylates. In situ polymerization via Michael addition proceeds under ambient conditions, yielding polyurethanes with a large variety of chemical functionalities. Side-chain funct...

  1. Seasonal patterns in metazoan parasite community of the "Fat Sleeper" Dormitator latifrons (Pisces: Eleotridae from Tres Palos Lagoon, Guerrero, Mexico

    Directory of Open Access Journals (Sweden)

    Juan Violante-González

    2008-09-01

    Full Text Available Dormitator is among the most important fish genera in the Mexican Pacific coastal lagoon systems. In Tres Palos Lagoon, the Fat Sleeper Dormitator latifrons is one of the most significant species based on catch volume, although it is only consumed locally. Very little information exists on this species’ parasitofauna. Composition and temporal variation in the metazoan parasite community structure of Dormitator latifrons from Tres Palos Lagoon (99º47’ W, 16º48’ N, Guerrero, Mexico, were determined using seasonal samples taken between April 2000 and June 2002. Ten parasite species (55 817 individuals were recovered from 219 examined hosts. These species included eight helminths (Ascocotyle (Phagicola longa, Echinochasmus leopoldinae, Clinostomum complanatum, Pseudoacanthostomum panamense, Saccocoelioides lamothei, Parvitaenia cochlearii, Contracaecum sp. and Neoechinorhynchus golvani and two crustaceans (Argulus sp. and Ergasilus sp.. Five of the helminth species exhibited seasonal variation in their infection dynamics associated with environmental changes during the dry and rainy seasons. The variations in the infection dynamics generated changes in the community structure over time. Rev. Biol. Trop. 56 (3: 1419-1427. Epub 2008 September 30.Entre abril del 2000 y junio del 2002 se efectuó un estudio para determinar la composición y la variación temporal en la estructura de la comunidad de parásitos metazoarios del popoyote Dormitator latifrons en la laguna de Tres Palos, Guerrero, México, a partir de muestras temporales. Se recuperaron diez especies de parásitos (55 817 individuos de 219 hospederos examinados. Estas especies incluyeron ocho helmintos (Ascocotyle (Phagicola longa, Echinochasmus leopoldinae, Clinostomum complanatum, Pseudoacanthostomum panamense, Saccocoelioides lamothei, Parvitaenia cochlearii, Contracaecum sp. y Neoechinorhynchus golvani y dos crustáceos (Argulus sp. y Ergasilus sp.. Cinco de las especies de

  2. Estimates of consumptive use and ground-water return flow using water budgets in Palo Verde Valley, California

    Science.gov (United States)

    Owen-Joyce, Sandra J.; Kimsey, Steven L.

    1987-01-01

    Palo Verde Valley, California, is an agricultural area in the flood plain of the Colorado River where irrigation water is diverted from the river and groundwater is discharged to a network of drainage ditches and (or) the river. Consumptive use by vegetation and groundwater return flow were calculated using water budgets. Consumptive use by vegetation was 484,000 acre-ft in 1981, 453,600 acre-ft in 1982, 364,400 acre-ft in 1983, and 374,300 acre-ft in 1984. The consumptive-use estimates are most sensitive to two measured components of the water budget, the diversion at Palo Verde Dam and the discharge from drainage ditches to the river. Groundwater return flow was 31,700 acre-ft in 1981, 24,000 acre-ft in 1982, 2,500 acre-ft in 1983, and 7 ,900 acre-ft in 1984. The return-flow estimates are most sensitive to discharge from drainage ditches; various irrigation requirements and crop areas, particularly alfalfa; the diversion at Palo Verde Dam; and the estimate of consumptive use. During increasing flows in the river, the estimate of groundwater return flow is sensitive also to change in groundwater storage. Change in groundwater storage was estimated to be -5,700 acre-ft in 1981, -12,600 acre-ft in 1982, 5,200 acre-ft in 1983, and 11 ,600 acre-ft in 1984. Changes in storage can be a significant component in the water budget used to estimate groundwater return flow but is negligible in the water budget used to estimate consumptive use. Change in storage was 1 to 3% of annual consumptive use. Change in storage for the area drained by the river ranged from 7 to 96% of annual groundwater return flow during the 4 years studied. Consumptive use calculated as diversions minus return flows was consistently lower than consumptive use calculated in a water budget. Water-budget estimates of consumptive use account for variations in precipitation, tributary inflow, river stage, and groundwater storage. The calculations for diversions minus return flows do not account for these

  3. Thiol-Ene Based Polymer Waveguides Fabricated By Uv-Assisted Soft Lithography For Optofluidic Applications

    DEFF Research Database (Denmark)

    Zhuang, Guisheng; Jensen, Thomas Glasdam; Kutter, Jörg Peter

    2011-01-01

    In this paper, a thiol-ene based polymer waveguide, defined by UV-assisted soft lithography, is designed, fabricated and characterized. Waveguides are formed by filling microfluidic channels with a high refractive index liquid mixture of ‘thiol’ and ‘ene’ monomers (e.g., trimethylolpropane tris(3...... thiol-ene based polymers as waveguide core materials for potential optofluidic applications.......In this paper, a thiol-ene based polymer waveguide, defined by UV-assisted soft lithography, is designed, fabricated and characterized. Waveguides are formed by filling microfluidic channels with a high refractive index liquid mixture of ‘thiol’ and ‘ene’ monomers (e.g., trimethylolpropane tris(3......-mercaptopropionate) = ‘thiol’, and 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione = ‘ene’), which can be cured by UV exposure into a solid polymer. The waveguides demonstrated good confinement of light, and a propagation loss of 0.5 dB/cm was obtained. To our best knowledge, this is the first report to employ...

  4. Facile and Efficient Synthesis of Carbosiloxane Dendrimers via Orthogonal Click Chemistry Between Thiol and Ene.

    Science.gov (United States)

    Zhang, Zhida; Feng, Shengyu; Zhang, Jie

    2016-02-01

    A combination of a thiol-Michael addition reaction and a free radical mediated thiol-ene reaction is employed as a facile and efficient approach to carbosiloxane dendrimer synthesis. For the first time, carbosiloxane dendrimers are constructed rapidly by an orthogonal click strategy without protection/deprotection procedures. The chemoselectivity of these two thiol-ene click reactions leads to a design of a new monomer containing both electron-deficient carbon-carbon double bonds and unconjugated carbon-carbon double bonds. Siloxane bonds are introduced as the linker between these two kinds of carbon-carbon double bonds. Starting from a bifunctional thiol core, the dendrimers are constructed by iterative thiol-ene click reactions under different but both mild reaction conditions. After simple purification steps the fifth dendrimer with 54 peripheral functional groups is obtained with an excellent overall yield in a single day. Furthermore, a strong blue glow is observed when the dendrimer is excited by a UV lamp. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Manifestaciones geomorfológicas y geofísicas de una estructura geológica profunda al sur de la Sierra de Pie de Palo, Sierras Pampeanas Geomorphological and geophysical features of the deep structure of southern Pie de Palo, Sierra Pampeanas

    OpenAIRE

    M. Patricia Martínez; Laura P. Perucca; Mario E. Giménez; Francisco Ruíz

    2008-01-01

    En el presente trabajo se vinculan las evidencias geomorfológicas y geofísicas con la existencia de una estructura emplazada en la corteza superior, ubicada al sur de la sierra de Pie de Palo y con similares dimensiones que ésta. A partir de valores de gravedad, se calculó una carta de anomalías de Bouguer, correspondiente a la sierra de Pie de Palo y zonas aledañas. Se aplicó el método de deconvolución de Euler, variando adecuadamente el ancho de ventana entre 20 y 35 km y con dos índices es...

  6. Currents, temperature, conductivity, attenuation, and sigma-theta data from moorings deployed off the coast of Palos Verdes, CA from platforms VICKERS and ROBERT GORDON SPROUL from May 21, 1992 and March 30, 1993 (NODC Accession 0067573)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The sediments on the shelf off Palos Verdes CA are contaminated with large amounts of DDT. Moorings were deployed on the shelf in the winter of 1993 in part to...

  7. An orthogonal, one-pot, simultaneous UV-mediated route to thiol-ene/sol-gel film

    Directory of Open Access Journals (Sweden)

    A. Chemtob

    2016-06-01

    Full Text Available We describe a novel combination of orthogonal reactions based on UV-driven thiol–ene and alkoxysilyl condensation reactions to form a single-step route toward thioether-bridged silsesquioxane films. Our chemical strategy consists of using two bifunctional (methacrylate (E and propanethiol (T trimethoxysilyl precursors containing two complementary functional moieties for thiol-ene coupling and sol-gel process. The reaction kinetics revealed that c.a. 85% of thiol and ene conversions were consumed concomitantly. Meanwhile, a complete hydrolysis was accomplished, affording ultimately a high degree of condensation (81%. Emphasis was placed on differences of mechanical properties between sol-gel hybrids resulting from thiol-ene reaction (E-T mixture and ene homopolymerization (E only using scratch test measurements. For the methacrylate system, the formation of thioether linkages within a vitreous silica network emerged as a useful strategy for the formation of a uniform, low-stress and flexible crosslinked hybrid structure. Enhanced mechanical properties were manifested by an expanded elastic domain, and better resistance to cracking. Moreover, there are clear indications that mechanical properties can be easily tuned upon varying the ratio of the two hybrid precursors.

  8. Advantages and drawbacks of Thiol-ene based resins for 3D-printing

    Science.gov (United States)

    Leonards, Holger; Engelhardt, Sascha; Hoffmann, Andreas; Pongratz, Ludwig; Schriever, Sascha; Bläsius, Jana; Wehner, Martin; Gillner, Arnold

    2015-03-01

    The technology of 3D printing is conquering the world and awakens the interest of many users in the most varying of applications. New formulation approaches for photo-sensitive thiol-ene resins in combination with various printing technologies, like stereolithography (SLA), projection based printing/digital light processing (DLP) or two-photon polymerization (TPP) are presented. Thiol-ene polymerizations are known for its fast and quantitative reaction and to form highly homogeneous polymer networks. As the resins are locally and temporally photo-curable the polymerization type is very promising for 3D-printing. By using suitable wavelengths, photoinitiator-free fabrication is feasible for single- and two photon induced polymerization. In this paper divinyl ethers of polyethylene glycols in combination with star-shaped tetrathiols were used to design a simple test-system for photo-curable thiol-ene resins. In order to control and improve curing depth and lateral resolution in 3D-polymerization processes, either additives in chemical formulation or process parameters can be changed. The achieved curing depth and resolution limits depend on the applied fabrication method. While two-/multiphoton induced lithography offers the possibility of micron- to sub-micron resolution it lacks in built-up speed. Hence single-photon polymerization is a fast alternative with optimization potential in sub-10-micron resolution. Absorber- and initiator free compositions were developed in order to avoid aging, yellowing and toxicity of resulting products. They can be cured with UV-laser radiation below 300 nm. The development at Fraunhofer ILT is focusing on new applications in the field of medical products and implants, technical products with respect to mechanical properties or optical properties of 3D-printed objects. Recent process results with model system (polyethylene glycol divinylether/ Pentaerithrytol tetrakis (3-mercaptopropionat), Raman measurements of polymer conversion

  9. Roll-to-plate fabrication of microfluidic devices with rheology-modified thiol-ene resins

    DEFF Research Database (Denmark)

    Senkbeil, Silja; Aho, Johanna; Yde, Leif

    2016-01-01

    In this paper, the replication possibilities of microfluidic channels by UV-roll-to-plate fabrication were investigated and a study of rheology-modified thiol-ene for the application in such a UV-roll-to-plate setup was conducted. The system allows the manufacture of channels with aspect ratios...... microfluidic channels with 40 × 95 μm cross-sectional dimensions. Moreover, deeper (90 μm) channels can be fabricated with highly viscous resins based on thiol-terminated oligomers. As a demonstration, capillary electrophoresis chips were prepared and tested for a simple separation of two fluorescent dyes....

  10. A Santería/Palo Mayombe ritual cauldron containing a human skull and multiple artifacts recovered in western Massachusetts, U.S.A.

    Science.gov (United States)

    Pokines, James T

    2015-03-01

    Santería and Palo Mayombe are West African-derived religions/sects with components of Catholicism, and both involve the ritual use of nonhuman skeletal remains which make them an increasing object of forensic interest. Palo Mayombe specifically involves also the use of human skeletal remains placed within ritual cauldrons or ngangas along with multiple ritual artifacts. A case of a nganga recovered from a periodically drained canal in Western Massachusetts, U.S.A. is presented. This nganga contained multiple items indicating its origin, including railroad spikes, coins, other metal objects, a stone, a glass bead, and multiple labeled and unlabeled sticks and was associated with a knife. It also contained skeletal remains of a bird and a snake as well as a nearly intact human skull of an adult male. The origin of the human remains is likely from a cemetery or as a former anatomical specimen. The find of this nganga is atypical in that it is away from the usual urban centers of Palo Mayombe in the U.S.A., and forensic practitioners should be aware that such sources of human remains may occur in their jurisdictions. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  11. Synthesis of 2-ene-1,4-diols by a new cascade-opening of 1,3-diepoxides: towards an efficient synthesis of dihydroxytaxoid derivatives.

    Science.gov (United States)

    Aldegunde, María J; Castedo, Luis; Granja, Juan R

    2009-01-01

    Taxing taxanes: A new method for the preparation of alk-2-ene-1,4-diols from 1,3-dienes, especially for geometrical constrained derivatives, via dioxirane derivative formation followed by Ti(III)-induced oxirane ring opening, is described. The strategy has been very efficiently implemented to the construction of the 11-ene-10,13-diol moiety present in taxol derivatives.

  12. Use of a continuous-flow microreactor for thiol-ene functionalization of RAFT-derived poly(butyl acrylate)

    OpenAIRE

    Vandenbergh, Joke; Junkers, Thomas

    2012-01-01

    This study describes the synthesis of functionalized RAFT-derived poly(n-butyl acrylate) polymers via the use of a continuous-flow microreactor, in which aminolysis as well as thiol-ene reactions are executed in reaction times of just 20 minutes. Poly(n-butyl acrylate) (M-n = 3800 g mol(-1), PDI = 1.10) with a trithiocarbonate end group was prepared via a conventional RAFT process. The polymer was then functionalized via aminolysis/thiol-ene reactions in the micro-flow reactor with isobornyl ...

  13. Synthesis and characterization of thiol-ene functionalized siloxanes and evaluation of their polymerization kinetics, network properties, and dental applications

    Science.gov (United States)

    Cole, Megan A.

    We explored formation-structure-property relationships in thiol-ene functionalized oligosiloxanes to create crosslinked networks. Specifically, nine oligomers were synthesized, three with thiol-functional silane repeats and three with allyl-functional silane repeats. Structural variations in each oligomer were systematically induced through the incorporation of non-reactive repeats bearing either diphenyl or di-n-octyl moieties, and the oligomer molecular weight was limited by the presence of monofunctional silane condensation species. The molecular weights and chain compositions of all oligomers were ascertained and subsequently used in the evaluation of network properties formed upon photopolymerization of thiol- and ene-functional reactants. Polymerization kinetics of the thiol-ene functionalized siloxanes were also investigated using photoinitiation owing to the spatial and temporal control afforded by this technique. In particular, the effects of the viscosity of the ene-functionalized oligomer and the degree of thiol functionalization on the observed polymerization rate were determined. Results showed that the speed of polymerization varied with changes to the rate-limiting step, which was heavily influenced by neighboring non-reactive functionalities. Moreover, the thiol-ene reaction was found to exhibity unimolecular termination exclusively in siloxane-based systems. Proposed use of the thiol-ene functionalized siloxane system as a dental impression material necessitated the development of a redox initiation scheme. Evaluation of the benzoylperoxide/dimethyl-p-toluidine redox pair in traditional systems showed bulk thiol-ene polymerizations comparable to photoinitiation with the added advantage of uninhibited depth control, as also demonstrated in small molecule thiol-ene coupling reactions initiated by this same redox system. Application of the redox pair to the siloxane system allowed for the viscoelastic properties as well as the feature replication

  14. Advanced functionalization of polyhydroxyalkanoate via the UV-initiated thiol-ene click reaction.

    Science.gov (United States)

    Tajima, Kenji; Iwamoto, Kosuke; Satoh, Yasuharu; Sakai, Ryosuke; Satoh, Toshifumi; Dairi, Tohru

    2016-05-01

    Polyhydroxyalkanoates (PHAs) incorporating vinyl-bearing 3-hydroxyalkanoates were prepared in 8.5-12.9 g L(-1) yield. The molar ratios (0-16 mol%) of the vinyl-bearing 3-hydroxyalkanoate derivatives were controlled by the continuous feeding of undecylenate at various concentrations. Subsequently, the PHAs were functionalized by UV-initiated thiol-ene click reaction and chemical modification. (1)H NMR spectra suggested that 3-mercaptopropionic acid and 2-aminoethanethiol were successfully introduced into the vinyl-bearing PHA. Subsequently, chemical modification using fluorescein or a fibronectin active fragment (GRGDS) was attempted. The former yielded a PHA derivative capable of emitting fluorescence under UV irradiation, which was useful for determining the miscibility of PHA in a composite film comprising poly-ʟ-lactic acid (PLLA) and PHA. In the latter case, PHA bearing GRGDS peptides exhibited cell adhesiveness, suggesting that its biocompatibility was improved upon peptide introduction. Taken together, the UV-initiated thiol-ene click reaction was demonstrated to be useful in PHA modification.

  15. Self-Healing Photocurable Epoxy/thiol-ene Systems Using an Aromatic Epoxy Resin

    Directory of Open Access Journals (Sweden)

    Ricardo Acosta Ortiz

    2016-01-01

    Full Text Available A rapid and efficient method to obtain self-healing epoxy resins is discussed. This method is based on the use of a thiol-disulfide oligomer obtained by partial oxidation of a multifunctional thiol using a hypervalent iodine (III compound as oxidant. The oligomer was characterized by Fourier transform infrared spectroscopy (FTIR, Raman and nuclear magnetic resonance spectroscopies, and gel permeation chromatography (GPC. The oligomer was a joint component of the thiol-ene system along with a tetra-allyl-functionalized curing agent. The kinetics of the photopolymerization of diglycidylether of bisphenol A (DGEBA revealed that conversions of the epoxy groups as high as 80% were achieved in only 15 minutes by increasing the concentration of the thiol-ene system in the formulation. The disulfide bonds introduced in the copolymer using the thiol-disulfide oligomer allowed the repairing of the test specimens in as little as 10 minutes when the specimens were heated at 80°C or for 500 minutes at room temperature. The analysis of the mechanical properties using dynamic mechanical analysis (DMA showed that the specimens displayed a healing efficiency up to 111% compared with the unhealed specimens, depending on the amount of polythioethers present in the copolymer.

  16. Spatial distribution of Guaiacum sanctum (Zygophyllaceae seedlings and saplings relative to canopy cover in Palo Verde National Park, Costa Rica

    Directory of Open Access Journals (Sweden)

    Eric J. Fuchs

    2013-09-01

    Full Text Available The spatial distribution of individuals is a fundamental property of most species and constitutes essential information for the development of restoration and conservation strategies, especially for endangered plant species. In this paper we describe the spatial distribution of different size classes of the endangered tropical tree Guaiacum sanctum and the effect of canopy cover on spatial aggregation. Adult G. sanctum were located and mapped in a 50ha plot in Palo Verde National Park, Costa Rica. Seedlings, saplings and juveniles were mapped to the nearest centimetre and permanently marked in three 50x50m subplots. Within each subplot spatial aggregation was assessed using Ripley’s K statistic and canopy opening readings were performed every 5m using a densitometer. Kriging spatial interpolation and Monte Carlo simulations were used to determine if average canopy cover differed among size classes. Individuals of G. sanctum were spatially aggregated at all size classes with seedlings being the most frequent size class in all subplots. Seedlings were found predominantly in areas with significantly higher canopy cover. In contrast, juveniles were more likely found in areas with higher light availability. The high number of seedlings, saplings, and juveniles relative to adults suggests that populations of G. sanctum in PVNP are expanding. Light availability and canopy structure are important factors shaping the spatial distribution of this species. The contemporary demographic structure of G. sanctum is dependent on forest gap dynamics and changes in human disturbance during the past 25 years.

  17. Spatial and temporal distribution of contaminated, effluent-affected sediment on the Palos Verdes margin, southern California

    Science.gov (United States)

    Lee, Homa J.; Sherwood, Christopher R.; Drake, David E.; Edwards, Brian D.; Wong, Florence; Hamer, Michael

    2002-05-01

    A sedimentary deposit on the continental margin near the Palos Verdes Peninsula, California is comprised of sewage effluent and geologic materials and is contaminated with metals, pesticides (including DDT and associated compounds), and PCBs. The deposit was mapped with subbottom acoustic profilers, and sediment cores were analyzed for geochemical and physical properties to determine the volume of the deposit and the distribution and mass of contaminants. Mapping showed that the deposit ranges up to 60-cm thick, has a total volume exceeding 9 million m 3, and covers over 40 km 2. Virtually the entire effluent-affected deposit is contaminated with DDT and PCBs. Nearly half of the area of the deposit lies on the continental slope, but 70-75% of the volume of the deposit and total mass of DDT reside on the continental shelf. Analysis of data collected biennially since 1981 by the Sanitation Districts of Los Angeles County show that the mass of DDT has apparently decreased at some stations but has remained essentially constant at others. Temporal changes in mass per unit area of DDT are not statistically significant (at the 90% confidence level) at the most contaminated locations over a 16-yr period. The results of this mapping effort were used as a basis for modeling efforts described elsewhere in this issue.

  18. Numerical analysis of the mobility of the Palos Verdes debris avalanche, California, and its implication for the generation of tsunamis

    Science.gov (United States)

    Locat, J.; Lee, H.J.; Locat, P.; Imran, J.

    2004-01-01

    Analysis of morphology, failure and post-failure stages of the Palos Verdes debris avalanche reveals that it may have triggered a significant tsunami wave. Our analysis of the failure itself indicates that the slope is stable under aseismic conditions but that a major earthquake (with a magnitude around 7) could have triggered the slide. A post-failure analysis, considering the debris avalanche as a bi-linear flow, shows that peak velocities of up to 45 m/s could have been reached and that the initial movement involved a mass of rock less than 10 km wide, 1 km long and about 50-80 m thick. Initial wave height estimates vary from 10 to 50 m. Tsunami waves propagating to the local shoreline would be significantly smaller. Such a range demonstrates our lack of proper knowledge of the transition from failure to post-failure behavior related to mass movements. Further investigations and analyses of terrestrial and submarine evidence are required for a proper hazard assessment related to tsunami generation in the Los Angeles area. ?? 2003 Elsevier B.V. All rights reserved.

  19. Regional underpressuring in Deep Brine Aquifers, Palo Duro Basin, Texas: 2. The effect of Cenozoic basin development

    Science.gov (United States)

    Senger, Rainer K.; Kreitler, Charles W.; Fogg, Graham E.

    1987-08-01

    The evolution of sedimentary basins, involving uplift, deposition, and erosion causes major changes in basin hydrodynamics and the hydrochemistry of basinal fluids. The role of these geologic processes is examined in the Palo Duro Basin of Texas with the help of a cross-sectional groundwater flow model employing time-dependent boundary conditions and a source term representing erosional unloading. Transient simulations of groundwater flow show that uplift and tilting of the basin (10-15 m.y. ago) caused a significant increase in groundwater flow rates. Timing of the erosional events implies that significant underpressuring (head difference between shallow and deep aquifers in excess of 175 m) and change in the groundwater flow pattern occurred within the last 1-2 m.y. as a result of erosional retreat of the Eastern Caprock Escarpment. Modeling also indicates that erosional unloading associated with the retreat of the Caprock Escarpment was ineffective in creating large-scale underpressuring in the Deep-Basin Brine aquifer. Only in the vicinity of the escarpment could erosional unloading and the resulting expansion of the underlying aquitard create significant subhydrostatic conditions within the aquitard.

  20. Regional underpressuring in deep brine aquifers, Palo Duro Basin, Texas 2. The effect of Cenozoic Basin Development

    Energy Technology Data Exchange (ETDEWEB)

    Senger, R.K.; Kreitler, C.W.; Fogg, G.E.

    1987-08-01

    The evolution of sedimentary basins, involving uplift, deposition, and erosion causes major changes in basin hydrodynamics and the hydrochemistry of basinal fluids. The role of these geologic processes is examined in the Palo Duro Basin of Texas with the help of a cross-sectional ground water flow model employing time-dependent boundary conditions and a source term representing erosional unloading. Transient simulations of ground water flow show that uplift and tilting of the basin (10-15 m.y. ago) caused a significant increase in ground water flow rates. Timing of the erosional events implies that significant underpressuring (head difference between shallow and deep aquifers in excess of 175 m) and change in the ground water flow pattern occurred within the last 1-2 m.y. as a results of erosional retreat of the Eastern Caprock Escarpment. Modeling also indicates that erosional unloading associated with the retreat of the Caprock Escarpment was ineffective in creating large-scale underpressuring in the Deep-Basin Brine aquifer. Only in the vicinity of the escarpment could erosional unloading and the resulting expansion of the underlying aquitard create significant subhydrostatic conditions within the aquitard.

  1. Kas erivajadustega lapsed saavad õigel ajal abi? / Ene Mägi, Urve Raudsepp-Alt, Ale Sprenk, Peeter Aas

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad: Tallinna Ülikooli Kasvatusteaduste Instituudi eri- ja sotsiaalpedagoogika osakonna juhataja Ene Mägi, Tallinna Haridusameti üldhariduse osakonna peaspetsialist Urve Raudsepp-Alt, Krabi põhikooli direktor Ale Sprenk, Põlva Maavalitsuse haridus-, kultuuri- ja sotsiaalosakonna juhataja Peeter Aas

  2. Mida teie oma tervise heaks teete? / Ly Jagor, Ülle Mihhailova, Ene Pill, Katrin Käbin...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad Pärnu Õppenõustamiskeskuse psühholoog Ly Jagor, Maasika lasteaia juhataja asetäitja Ülle Mihhailova, Tallinna Perekeskuse ja Tähetorni lastekeskuse psühholoog Ene Pill, Tallinna Nõmme Noortemaja väikelaste ringijuht Katrin Käbin, Tääksi Põhikooli õpetaja Silva Kolk

  3. Photoinduced thiol-ene polymerization reaction for fast preparation of macroporous hybrid monoliths and their application in capillary liquid chromatography.

    Science.gov (United States)

    Liu, Zhongshan; Ou, Junjie; Lin, Hui; Liu, Zheyi; Wang, Hongwei; Dong, Jing; Zou, Hanfa

    2014-08-25

    Hybrid monoliths with a macroporous structure were prepared within a few minutes via a photoinduced thiol-ene polymerization reaction, the surfaces of which showed hydrophobic character. The monolithic column demonstrated good separation performance towards alkylbenzenes, peptides, proteins and BSA tryptic digest in cLC.

  4. Efficient Functionalization of Oxide-Free Silicon(111) Surfaces: Thiol–yne versus Thiol–ene Click Chemistry

    NARCIS (Netherlands)

    Bhairamadgi, N.S.; Gangarapu, S.; Caipa Campos, M.A.; Paulusse, Jos Marie Johannes; van Rijn, C.J.M.; Zuilhof, H.

    2013-01-01

    Thiol-yne click (TYC) chemistry was utilized as a copper-free click reaction for the modification of alkyne-terminated monolayers on oxide-free Si(111) surfaces, and the results were compared with the analogous thiol–ene click (TEC) chemistry. A wide range of thiols such as

  5. Luuletus Halbdeutschis ja mõned küsimused substraadi kohta / Ilse Lehiste ; tlk. Ene-Reet Soovik

    Index Scriptorium Estoniae

    Lehiste, Ilse, 1922-2010

    2000-01-01

    Jacob Johann Malmi poolsaksakeelne satiiriline luuletus "Die Oberpalsche Freundschaft" aastast 1818 - luuletuse substraatkeelte eesti ja baltisaksa vokaalide ja konsonantsüsteemi ning grammatilise struktuuri võrdlus. Ilmunud: A poem in Halbdeutsch and some questions concerning substratum // Word 21, 1965, lk. 55-69. Tõlk. Ene-Reet Soovik

  6. Surface Modification of Poly(divinylbenzene) Microspheres via Thiol-Ene Chemistry and Alkyne-Azide Click Reactions

    NARCIS (Netherlands)

    Goldmann, Anja S.; Walther, Andreas; Nebhani, Leena; Joso, Raymond; Ernst, Dominique; Loos, Katja; Barner-Kowollik, Christopher; Barner, Leonie; Mueller, Axel H. E.; Müller, Axel H.E.

    2009-01-01

    We report the functionalization of cross-linked poly(divinylbenzene) (pDVB) microspheres using both thiol-ene chemistry and azide-alkyne click reactions. The RAFT technique was carried out to synthesize SH-functionalized poly(N-isopropylacrylimide) (pNIPAAm) and utilized to generate pNIPAAm

  7. Highly stretchable thermoset fibers and nonwovens using thiol-ene photopolymerization.

    Science.gov (United States)

    Shanmuganathan, Kadhiravan; Elliot, Steven M; Lane, Austin P; Ellison, Christopher J

    2014-08-27

    In this report, we describe the preparation and characterization of a new class of thermoset fibers with high elongation and elastic recovery. Integrating UV-activated thiol-ene photopolymerization and electrospinning, we demonstrate an environmentally friendly single step approach to convert small monomeric precursor molecules into highly elastic fibers and nonwoven mats. The fibers were derived by in situ photopolymerization of a trifunctional vinyl ether monomer and a tetrafunctional thiol. Although thermosets often offer good chemical and thermal stability, these fibers also have a high average elongation at break of 62%. The elastomeric nature of these vinyl-ether based fibers can be partly attributed to their subambient Tg and partly to the cross-link density, monomer structure, and resulting network homogeneity. Nonwoven mats of these fibers were also stretchable and exhibited a much higher elongation at break of about 85%. These thermoset stretchable fibers could have potential applications as textile, biomedical, hot chemical filtration, and composite materials.

  8. Photolithographic fabrication of solid–liquid core waveguides by thiol-ene chemistry

    DEFF Research Database (Denmark)

    Sagar, Kaushal Shashikant; Gopalakrishnan, Nimi; Christiansen, Mads Brøkner

    2011-01-01

    . The generated refractive index contrast between the patterned water-filled volume and the surrounding empty hydrophobic porous polymer allows for light confinement within the water-filled volume—the solid–liquid core. The presented fabrication process is simple and fast. It allows a high degree of flexibility...... are comparable with literature values for state-of-the-art liquid-core waveguide devices. The demonstrated waveguide function added to the nanoporous polymer with a very high internal surface area makes the system interesting for many applications in different areas, such as diagnostics and bio-chemical sensing.......In this work we demonstrate an efficient and cleanroom compatible method for the fabrication of solid–liquid core waveguides based on nanoporous polymers. We have used thiol-ene photo-grafting to tune and pattern the hydrophilicity of an originally hydrophobic nanoporous 1, 2-polybutadiene...

  9. Hydrophobic thiol-ene surfaces fabricated via plasma activation and photo polymerization

    Science.gov (United States)

    Champathet, P.; Ervithayasuporn, V.; Osotchan, T.; Dangtip, S.

    2017-09-01

    Alumina, such as glazed alumina for electrical insulator, operated in an open field subjects to a very harsh condition; resulting in lifetime shortening. Coating hydrophobic layer on alumina surface can help prolonging its lifetime. In this study, 25 ×25 mm alumina sheets were used as substrates. The hydrophobic composite polymers were prepared from (3-mercaptopropyl)trimethoxysilane(MPTMS), 2,4,6,8-tetramethyl-2,4,6,8tetravinylcyclotetra siloxane(TMTVSi), pentaerythritoltetra(3-mercaptopropionate)(PETMP), 2,2-dimethoxy-2-phe nylaceto phenone(photoinitiator) and heptadecafluorodecylmethacrylate(HEFDMA) via the thiol-ene reaction. The alumina sheets were first activated by dielectric-barrier discharge plasma to improve its adhesion. All the polymers were found to optimize at the ratio of (MPTMS:TMTVSi:PETMP:HDFDMA) to 4:2:1:2 for coating on the alumina substrate. To enhance polymerization, 2,2-dimethoxy-2-phenylaceto phenome was also used as a photoinitiator A proper mixing sequence in the thiol-ene reaction results in film with excellent surface retention after prolong soaking in solvent such as acetone. FTIR shows that S-H and C=C functional groups have significantly changed after photopolymerization and thermally cured. The static contact angle increase from mere 53.0°±1.5° of the uncoated substrate to 120.0°±1.2° after coating. SEM shows the film with clear appearance of a few-micron thick. Under AFM, the coated surface roughness was about 9.3 nm with evenly distributed spikes of a few nanometer in height. The cross-cut test also confirmed the film was very smooth and none of the square of the films detached.

  10. Hydrophobic Coatings by Thiol-Ene Click Functionalization of Silsesquioxanes with Tunable Architecture.

    Science.gov (United States)

    Dirè, Sandra; Bottone, Davide; Callone, Emanuela; Maniglio, Devid; Génois, Isabelle; Ribot, François

    2017-08-08

    The hydrolysis-condensation of trialkoxysilanes under strictly controlled conditions allows the production of silsesquioxanes (SSQs) with tunable size and architecture ranging from ladder to cage-like structures. These nano-objects can serve as building blocks for the preparation of hybrid organic/inorganic materials with selected properties. The SSQs growth can be tuned by simply controlling the reaction duration in the in situ water production route (ISWP), where the kinetics of the esterification reaction between carboxylic acids and alcohols rules out the extent of organosilane hydrolysis-condensation. Tunable SSQs with thiol functionalities (SH-NBBs) are suitable for further modification by exploiting the simple thiol-ene click reaction, thus allowing for modifying the wettability properties of derived coatings. In this paper, coatings were prepared from SH-NBBs with different architecture onto cotton fabrics and paper, and further functionalized with long alkyl chains by means of initiator-free UV-induced thiol-ene coupling with 1-decene (C10) and 1-tetradecene (C14). The coatings appeared to homogeneously cover the natural fibers and imparted a multi-scale roughness that was not affected by the click functionalization step. The two-step functionalization of cotton and paper warrants a stable highly hydrophobic character to the surface of natural materials that, in perspective, suggests a possible application in filtration devices for oil-water separation. Furthermore, the purification of SH-NBBs from ISWP by-products was possible during the coating process, and this step allowed for the fast, initiator-free, click-coupling of purified NBBs with C10 and C14 in solution with a nearly quantitative yield. Therefore, this approach is an alternative route to get sol-gel-derived, ladder-like, and cage-like SSQs functionalized with long alkyl chains.

  11. Amino acid-incorporated polymer network by thiol-ene polymerization

    Directory of Open Access Journals (Sweden)

    R. Yokose

    2015-08-01

    Full Text Available Triallyl L-alanine (A3A and triallyl L-phenylalanine (A3F were synthesized by reactions of L-alanine and L-phenylalanine with allyl bromide in the presence of sodium hydroxide, respectively. Thiol-ene thermal polymerization of A3A or A3F with pentaerythritol-based primary tetrathiol (pS4P or pentaerythritol-based secondary tetrathiol (S4P at allyl/SH 1/1 in the presence of 2,2'-azobis(isobutyronitrile produced an amino acid-incorporated polymer network (A3ApS4P, A3A-S4P or A3F-S4P. Although the thermally cured resins were homogeneous and flat films, the corresponding thiol-ene photopolymerization did not give a successful result. Degree of swelling for each thermally cured film in N,Ndimethylformamide was much higher than that in water. The glass transition and 5% weight loss temperatures (Tg and T5 of A3F-pS4P and A3F-S4P were higher than those of A3A-pS4P and A3A-S4P, respectively. Also, A3F-pS4P and A3F-S4P exhibited much higher tensile strengths and moduli than A3A-pS4P and A3A-S4P did, respectively. Consequently, A3FpS4P displayed the highest Tg (38.7°C, T5 (282.0°C, tensile strength (9.5 MPa and modulus (406 MPa among all the thermally cured resins.

  12. Structure of the Newport-Inglewood/Rose Canyon and Palos Verdes Fault Zones and Implications for Current Fault Models

    Science.gov (United States)

    Sahakian, V. J.; Bormann, J. M.; Klotsko, S.; Holmes, J. J.; Driscoll, N. W.; Harding, A. J.; Kent, G.; Wesnousky, S. G.

    2014-12-01

    Faulting in the Inner California Borderlands is complex. In the past, this region has undergone various deformational events such as extensional and rotational deformation to variable strike-slip deformation; this has imparted the geomorphology and fault structures observed offshore Southern California. Several hypotheses have been proposed to explain the current fault structures and the hazards they pose to populated coastal regions. The geometry and architecture of these structures can have significant implications for ground motions in the event of a rupture, and therefore impact working models of hazard assessment. Here, focusing on the Newport-Inglewood/Rose Canyon (NI/RC) and Palos Verdes (PV) fault zones, we use new and existing multibeam, CHIRP and Multi-Channel Seismic (MCS) data to describe the geometry of the fault system. We interpret reprocessed (prestack time migration) MCS data collected in 1979, 1986, and 2006 as well as newly acquired high-res MCS datasets collected offshore San Diego County. Combining these high and intermediate resolution datasets with very high resolution CHIRP data, we define structures that show distinct changes in the style of deformation through time, and place constraints on the segmentation of faults in this system. The timing of the most recent deformation on the NI/RC appears to vary along-strike. Likewise, the NI/RC fault's dip direction and angle appears to vary along-strike, and these changes in dip seem to mark the boundaries of restraining and releasing bends. Additionally, the NI/RC fault appears to die away to the north, possibly partitioning its strain on to the PV fault. We will present interpretations of the faults' current deformational activity as well as likelihood of rupture propagating across releasing/restraining bends, and discuss how this impacts current fault models that are employed for hazard assessment for Los Angeles and San Diego counties.

  13. Acoustic profiles and images of the Palos Verdes margin: implications concerning deposition from the White's Point outfall

    Science.gov (United States)

    Hampton, Monty A.; Karl, Herman A.; Murray, Christopher J.

    2002-05-01

    Subbottom profiles and sidescan-sonar images collected on and around the Palos Verdes Shelf show a surficial deposit interpreted to contain effluent from the White's Point diffusers, as well as showing several geologic features that affect the deposit's distribution. The effluent-affected deposit is visible in high-resolution subbottom profiles on the shelf and the adjacent San Pedro basin slope to water depths of 170 m. It has a maximum thickness of 75 cm and was mapped acoustically over an area of 10.8 km 2, which encompasses a volume of about 3.2 million m 3. The deposit's basal reflector is acoustically distinct over most of the mapped area, implying that the deposit has not been extensively mixed across its base, perhaps being relatively free of reworking since its initial deposition. Nearshore, the basal reflector is weak and fades away toward land, which could result from syndepositional intermixing of coarse native sediment (particularly from the Portuguese Bend landslide) with effluent in the high-energy nearshore zone, or postdepositionally by physical (wave) or biological mixing across the interface. The geometry of the deposit implies that effluent is dispersed primarily in a northwesterly and seaward direction from the diffusers. Dispersal across the shelf break is in some places strongly affected by topography, particularly by submarine canyons. The deposit overlies stratified and unstratified Quaternary sediment, up to 30 m thick, that in turn overlies the irregular erosional surface of deformed Miocene bedrock that crops out in places on the shelf and upper basin slope. The effluent-affected deposit rests on potentially unstable landslide deposits on the San Pedro basin slope. The acoustic profiles and side-scan images show evidence for active and inactive vents, probably of hot water and gas, some of which are within the boundary of the effluent-affected sediment deposit and could disrupt it if seepage occurs.

  14. Swern Oxidation of Bicyclo[2.2.1]hept-5-ene-2,3-diol and Its Pyrazine-fused Derivatives: An Improved Synthesis of Bicyclo[2.2.1]hept-5-ene-2,3-dione and An Unexpected Ring-Opening Reaction

    Directory of Open Access Journals (Sweden)

    Sayuri Kobayashi

    2000-09-01

    Full Text Available An improved synthesis of bicyclo[2.2.1]hept-5-ene-2,3-dione by Swern oxidation of bicyclo[2.2.1]hept-5-ene-2,3-diol, and an unexpected ring-opening reaction by the Swern oxidation of pyrazine-fused congeners are described.

  15. Comunidad de parásitos metazoarios de la charra Cichlasoma trimaculatum en la laguna de Tres Palos, Guerrero, México Metazoan parasite community in the three-spot cichlid Cichlasoma trimaculatum from Tres Palos Lagoon, Guerrero, Mexico

    Directory of Open Access Journals (Sweden)

    Juan Violante-González

    2008-12-01

    Full Text Available Entre abril de 2000 y noviembre de 2002 se examinó la composición de la comunidad de parásitos metazoarios de la charra, Cichlasoma trimaculatum a partir de muestras temporales. Fueron recuperadas 12 especies de parásitos (40 969 individuos de 231 hospederos examinados; 10 helmintos: Ascocotyle (Phagicola longa, Austrodiplostomum compactum, Cladocystis trifolium, Clinostomum complanatum, Crassicutis cichlasomae, Posthodiplostomum minimum, Pseudoacanthostomum panamense, Neoechinorhynchus golvani, Southwellina hispida y Contracaecum sp., y 2 crustáceos: Argulus sp. y Ergasilus sp. La comunidad se caracterizó por un número mayor de parásitos generalistas y pocos especialistas de cíclidos, además por ser pobre en especies. De las 5 especies comunes dentro de la comunidad, 4 presentaron variación temporal en su dinámica de infección a lo largo del tiempo, la cual fue asociada con cambios ambientales generados durante las temporadas de secas y lluvias. La variación en la dinámica de infección de las especies comunes fue capaz de generar cambios en la estructura, tanto en el nivel de componente como en el de infracomunidad; sin embargo, no se observó un patrón claro, lo que indica que la comunidad puede ser poco predecible, como se sugiere para otras comunidades de parásitos de peces dulceacuícolas.We analyzed metazoan parasite community composition in the three-spot cichlid Cichlasoma trimaculatum using seasonal samples taken between April 2000 and November 2002 from the Tres Palos Lagoon, Guerrero, Mexico. A total of 231 hosts were examined. Of the 12 parasite species recovered (40,969 individuals, 10 were helminths: Ascocotyle (Phagicola longa, Austrodiplostomum compactum, Cladocystis trifolium, Clinostomum complanatum, Crassicutis cichlasomae, Posthodiplostomum minimum, Pseudoacanthostomum panamense, Neoechinorhynchus golvani, Southwellina hispida, and Contracaecum sp. The remaining 2 were the crustaceans Argulus sp. and

  16. Near-field receiving water monitoring of trace metals and a benthic community near the Palo Alto Regional Water Quality Control Plant in south San Francisco Bay, California; 2015

    Science.gov (United States)

    Cain, Daniel J.; Thompson, Janet K.; Crauder, Jeffrey; Parchaso, Francis; Stewart, Robin; Turner, Matthew A.; Hornberger, Michelle I.; Luoma, Samuel N.

    2016-07-22

    Trace-metal concentrations in sediment and in the clam Macoma petalum (formerly reported as Macoma balthica), clam reproductive activity, and benthic macroinvertebrate community structure were investigated in a mudflat 1 kilometer south of the discharge of the Palo Alto Regional Water Quality Control Plant (PARWQCP) in South San Francisco Bay, California. This report includes data collected by U.S. Geological Survey (USGS) scientists for the period from January 2015 to December 2015. These data are appended to long-term datasets extending back to 1974, and serve as the basis for the City of Palo Alto’s Near-Field Receiving Water Monitoring Program, initiated in 1994.

  17. Near-field receiving water monitoring of trace metals and a benthic community near the Palo Alto Regional Water Quality Control Plant in south San Francisco Bay, California: 2014

    Science.gov (United States)

    Cain, Daniel J.; Thompson, Janet K.; Crauder, Jeff; Parcheso, Francis; Stewart, Robin; Kleckner, Amy E.; Dyke, Jessica; Hornberger, Michelle I.; Luoma, Samuel N.

    2015-01-01

    Trace-metal concentrations in sediment and in the clam Macoma petalum (formerly reported as Macoma balthica), clam reproductive activity, and benthic macroinvertebrate community structure were investigated in a mudflat 1 kilometer (km) south of the discharge of the Palo Alto Regional Water Quality Control Plant (PARWQCP) in South San Francisco Bay, Calif. This report includes the data collected by U.S. Geological Survey (USGS) scientists for the period January 2014 to December 2014. These append to long-term datasets extending back to 1974, and serve as the basis for the City of Palo Alto’s Near-Field Receiving Water Monitoring Program, initiated in 1994. 

  18. Manifestaciones geomorfológicas y geofísicas de una estructura geológica profunda al sur de la Sierra de Pie de Palo, Sierras Pampeanas

    OpenAIRE

    M. Patricia Martínez; Laura P. Perucca; Mario E. Giménez; Francisco Ruíz

    2008-01-01

    En el presente trabajo se vinculan las evidencias geomorfológicas y geofísicas con la existencia de una estructura emplazada en la corteza superior, ubicada al sur de la sierra de Pie de Palo y con similares dimensiones que ésta. A partir de valores de gravedad, se calculó una carta de anomalías de Bouguer, correspondiente a la sierra de Pie de Palo y zonas aledañas. Se aplicó el método de deconvolución de Euler, variando adecuadamente el ancho de ventana entre 20 y 35 km y con dos índices es...

  19. CARACTERIZACIÓN ESTRUCTURAL DEL MANGLAR EN EL ESTERO PALO VERDE, LAGUNA DE CUYUTLÁN, COLIMA

    Directory of Open Access Journals (Sweden)

    Citlalli P. Téllez-García

    2012-01-01

    Full Text Available En el Estero Palo Verde, ubicado en el vaso IV de la Laguna de Cuyutlán, estado de Colima, se establecieron 48 unidades de muestreo (UM en tres rodales de mangle: 10 UM en rodal monoespecífico de Laguncularia racemosa, 25 UM en rodal monoespecífico de Rhizophora mangle y 13 UM en rodal mixto de L. racemosa-R. mangle. Se registró altura del dosel, diámetro del tronco, densidad de adultos y de repoblación, también se calculó área basal y volumen de madera. Los resultados indicaron que la densidad, área basal y volumen, para la categoría diamétrica (CD de 5 cm fueron significativamente diferentes (P < 0.05 entre los rodales monoespecíficos de R. mangle (2,500 árboles•ha-1, 4.2 m2•ha-1 y 22 m3•ha-1, respectivamente y L. racemosa (700 árboles•ha-1, 1.9 m2•ha-1 y 10 m3•ha-1, respectivamente. En las CD de 20 a 30 cm, el área basal fue significativamente mayor (P < 0.05 en el rodal monoespecífico de L. racemosa (1.6 - 3.8 m2•ha-1 que en el mixto de L. racemosa-R. mangle (0.5 - 2.5 m2•ha-1. La repoblación natural fue más abundante en el rodal de R. mangle (138 a 270 individuos•ha-1 que en el de L. racemosa (70 a 80 individuos•ha-1. Los valores estructurales mayores se alcanzaron para altura del dosel (10 m en el rodal de L. racemosa; para diámetro (40 cm y área basal (14.1 m2•ha-1 en el rodal de L. racemosa-R. mangle; y para repoblación natural (624 individuos•ha-1 en el rodal de R. mangle.

  20. Ene-yne Cross-Metathesis for the Preparation of 2,3-Diaryl-1,3-dienes

    Directory of Open Access Journals (Sweden)

    Meriem K. Abderrezak

    2017-11-01

    Full Text Available Ene-yne cross-metathesis from alkynes and ethylene is a useful method to produce substituted conjugated butadiene derivatives. If this method has been used with aliphatic alkynes, it has however never been used starting from diarylacetylenes as internal alkynes. We show that the ene-yne cross-metathesis catalyzed by the second generation Hoveyda ruthenium catalyst provides the 2,3-diarylbuta-1,3-dienes under 3 atm of ethylene at 100 °C. The scope and limitations of the reaction have been evaluated starting from unsymmetrical functionalized diarylacetylene derivatives hence leading to unsymmetrical 2,3-diarylbuta-1,3-dienes in a straightforward and environmentally acceptable manner.

  1. Movement patterns, habitat use and site fidelity of the white croaker (Genyonemus lineatus) in the Palos Verdes Superfund Site, Los Angeles, California.

    Science.gov (United States)

    Wolfe, Barrett W; Lowe, Christopher G

    2015-08-01

    White croaker (Genyonemus lineatus family: Sciaenidae) are a schooling, benthic foraging fish historically associated with soft sediment and wastewater outfalls in southern California. While they are often used as an indicator species due to their high organochlorine contaminant loads, little is known of their movements in relation to contaminated habitats. A Vemco Positioning System acoustic telemetry array was used to collect fine-scale movement data and characterize the site fidelity, area use, and dispersal of 83 white croaker on the Palos Verdes Shelf Superfund Site, California over 27 months. White croaker generally demonstrated low residency and recurrence to the Palos Verdes Shelf, and were observed to be largely nomadic. However, individual behavior was highly variable. Although the entire monitored shelf was visited by tagged white croaker, habitats in 0-200 m proximity to wastewater outfalls and between 25 and 35 m depth were used most frequently. Approximately half of white croaker migrated into Los Angeles and Long Beach Harbors; areas where they may be targeted by subsistence fishers. A model framework for incorporating fish movement data into contaminant exposure estimates was developed to better understanding organochlorine contaminant exposure for planning future remediation and monitoring. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Emplazamiento hacia el ENE del manto de Los Reales (Alpujarrides occidentales: criterios estructurales y de petrofábrica

    Directory of Open Access Journals (Sweden)

    Tubía, J. M.

    1984-08-01

    Full Text Available Los Reales nappe rests over Ojén nappe to the North of Sierra Alpujata. The nappe contact zone shows a intense plastic deformation with mylonitic rocks, The deformation decreases progressively going away from the contacto The structural study of footwall and hangingwall roen permits to attribute this deformation to the Los Reales nappe emplacement over that of Ojén. The foliation and stretching lineation distributions show a WSW-ENE shear direction. The mylonite microstructural characteristics and the enstatite crystalline preferred orientations in the basal peridotites give a mear sense in according that, Los Reales nappe is displaced, in their present position, from the WSW towards the ENE.

    El manto de Los Reales descansa sobre el manto de Ojén, al norte de Sierra Alpujata. La zona de contacto entre mantos exhibe una intensa deformación plástica con rocas miloníticas; la deformación disminuye progresivamente al alejarse del contacto. El estudio estructural de las rocas infra y suprayacentes al contacto permite atribuir esta deformación al emplazamiento del manto de Los Reales sobre el de Ojén. , Las distribuciones de la foliación y de la lineación, de estiramiento indican una dirección de cizallamiento WSW-ENE. Las características microestructurales de las milonitas y las orientaciones preferentes cristalinas de la enstatita en las peridotitas basales proporcionan un sentido de cizallamiento tal que el manto de Los Reales se ha desplazado, en su posición actual, desde el WSW hacia el ENE.

  3. Vanemad mäletavad / Lain, Janet; Usin, Vello; Usin, Astra; Tiit, Birgit; Kuusk, Eneli; Kuusk, Vilja

    Index Scriptorium Estoniae

    2005-01-01

    Mõisaküla Keskkooli õpilased kogusid 2004. a. sügisel projekti "Mulgi murde päevad Mõisaküla koolis" raames vanemate inimeste mälestusi nende noorpõlvest ja kooliajast. Janet Lain pani kirja vanaisa Vello Usina ja vanaema Astra Usina mälestusi; Birgit Tiit ema Milvi Tiidu mälestusi ja Eneli Kuusk ema Vilja Kuuse mälestusi

  4. Aptamer-based organic-silica hybrid affinity monolith prepared via "thiol-ene" click reaction for extraction of thrombin.

    Science.gov (United States)

    Wang, Zheng; Zhao, Jin-cheng; Lian, Hong-zhen; Chen, Hong-yuan

    2015-06-01

    A novel strategy for preparing aptamer-based organic-silica hybrid monolithic column was developed via "thiol-ene" click chemistry. Due to the large specific surface area of the hybrid matrix and the simplicity, rapidness and high efficiency of "thiol-ene" click reaction, the average coverage density of aptamer on the organic-silica hybrid monolith reached 420 pmol μL(-1). Human α-thrombin can be captured on the prepared affinity monolithic column with high specificity and eluted by NaClO4 solution. N-p-tosyl-Gly-Pro-Arg p-nitroanilide acetate was used as the sensitive chromogenic substrate of thrombin. The thrombin enriched by this affinity column was detected with a detection of limit of 0.01 μM by spectrophotometry. Furthermore, the extraction recovery of thrombin at 0.15 μM in human serum was 91.8% with a relative standard deviation of 4.0%. These results indicated that "thiol-ene" click chemistry provided a promising technique to immobilize aptamer on organic-inorganic hybrid monolith and the easily-assembled affinity monolithic material could be used to realize highly selective recognition of trace proteins. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. ENED-GEM: A Conceptual Framework Model for Psychological Enjoyment Factors and Learning Mechanisms in Educational Games about the Environment.

    Science.gov (United States)

    Fjællingsdal, Kristoffer S; Klöckner, Christian A

    2017-01-01

    Based on a thorough review of psychological literature, this article seeks to develop a model of game enjoyment and environmental learning (ENvironmental EDucational Game Enjoyment Model, ENED-GEM) and delineate psychological processes that might facilitate learning and inspire behavioral change from educational games about the environment. A critically acclaimed digital educational game about environmental issues (Fate of the World by Red Redemption/Soothsayer Games) was used as a case study. Two hundred forty-nine reviews of the game from the popular gaming and reviewing platform known as Steam were analyzed by means of a thematic content analysis in order to identify key player enjoyment factors believed to be relevant to the process of learning from games, as well as to gain an understanding of positive and negative impressions about the game's general content. The end results of the thematic analysis were measured up to the suggested ENED-GEM framework. Initial results generally support the main elements of the ENED-GEM, and future research into the importance of these individual core factors is outlined.

  6. ENED-GEM: A Conceptual Framework Model for Psychological Enjoyment Factors and Learning Mechanisms in Educational Games about the Environment

    Science.gov (United States)

    Fjællingsdal, Kristoffer S.; Klöckner, Christian A.

    2017-01-01

    Based on a thorough review of psychological literature, this article seeks to develop a model of game enjoyment and environmental learning (ENvironmental EDucational Game Enjoyment Model, ENED-GEM) and delineate psychological processes that might facilitate learning and inspire behavioral change from educational games about the environment. A critically acclaimed digital educational game about environmental issues (Fate of the World by Red Redemption/Soothsayer Games) was used as a case study. Two hundred forty-nine reviews of the game from the popular gaming and reviewing platform known as Steam were analyzed by means of a thematic content analysis in order to identify key player enjoyment factors believed to be relevant to the process of learning from games, as well as to gain an understanding of positive and negative impressions about the game’s general content. The end results of the thematic analysis were measured up to the suggested ENED-GEM framework. Initial results generally support the main elements of the ENED-GEM, and future research into the importance of these individual core factors is outlined. PMID:28701988

  7. Spray-deposition and photopolymerization of organic-inorganic thiol-ene resins for fabrication of superamphiphobic surfaces.

    Science.gov (United States)

    Xiong, Li; Kendrick, Laken L; Heusser, Hannele; Webb, Jamie C; Sparks, Bradley J; Goetz, James T; Guo, Wei; Stafford, Christopher M; Blanton, Michael D; Nazarenko, Sergei; Patton, Derek L

    2014-07-09

    Superamphiphobic surfaces, exhibiting high contact angles and low contact angle hysteresis to both water and low surface tension liquids, have attracted a great deal attention in recent years because of the potential of these materials in practical applications such as liquid-resistant textiles, self-cleaning surfaces, and antifouling/anticorrosion coatings. In this work, we present a simple strategy for fabricating of superamphiphobic coatings based on photopolymerization of hybrid thiol-ene resins. Spray-deposition and UV photopolymerization of thiol-ene resins containing hydrophobic silica nanoparticles and perfluorinated thiols provide a multiscale topography and low-energy surface that endows the surface with superamphiphobicity. The wettability and chemical composition of the surfaces were characterized by contact-angle goniometry and X-ray photoelectron spectroscopy, respectively. The hierarchical roughness features of the thiol-ene surfaces were investigated with field-emission scanning electron microscopy. Droplet impact and sandpaper abrasion tests indicate the coatings respectively possess a robust antiwetting behavior and good mechanical durability.

  8. Superhydrophobic and Slippery Lubricant-Infused Flexible Transparent Nanocellulose Films by Photoinduced Thiol-Ene Functionalization.

    Science.gov (United States)

    Guo, Jiaqi; Fang, Wenwen; Welle, Alexander; Feng, Wenqian; Filpponen, Ilari; Rojas, Orlando J; Levkin, Pavel A

    2016-12-14

    Films comprising nanofibrillated cellulose (NFC) are suitable substrates for flexible devices in analytical, sensor, diagnostic, and display technologies. However, some major challenges in such developments include their high moisture sensitivity and the complexity of current methods available for functionalization and patterning. In this work, we present a facile process for tailoring the surface wettability and functionality of NFC films by a fast and versatile approach. First, the NFC films were coated with a layer of reactive nanoporous silicone nanofilament by polycondensation of trichlorovinylsilane (TCVS). The TCVS afforded reactive vinyl groups, thereby enabling simple UV-induced functionalization of NFC films with various thiol-containing molecules via the photo "click" thiol-ene reaction. Modification with perfluoroalkyl thiols resulted in robust superhydrophobic surfaces, which could then be further transformed into transparent slippery lubricant-infused NFC films that displayed repellency against both aqueous and organic liquids with surface tensions as low as 18 mN·m-1. Finally, transparent and flexible NFC films incorporated hydrophilic micropatterns by modification with OH, NH2, or COOH surface groups, enabling space-resolved superhydrophobic-hydrophilic domains. Flexibility, transparency, patternability, and perfect superhydrophobicity of the produced nanocellulose substrates warrants their application in biosensing, display protection, and biomedical and diagnostics devices.

  9. Polysiloxane-based luminescent elastomers prepared by thiol-ene "click" chemistry.

    Science.gov (United States)

    Zuo, Yujing; Lu, Haifeng; Xue, Lei; Wang, Xianming; Wu, Lianfeng; Feng, Shengyu

    2014-09-26

    Side-chain vinyl poly(dimethylsiloxane) has been modified with mercaptopropionic acid, methyl 3-mercaptopropionate, and mercaptosuccinic acid. Coordinative bonding of Eu(III) to the functionalized polysiloxanes was then carried out and crosslinked silicone elastomers were prepared by thiol-ene curing reactions of these composites. All these europium complexes could be cast to form transparent, uniform, thin elastomers with good flexibility and thermal stability. The networks were characterized by FTIR, NMR, UV/Vis, and luminescence spectroscopy as well as by scanning electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy. The europium elastomer luminophores exhibited intense red light at 617 nm under UV excitation at room temperature due to the (5)D0 →(7)F2 transition in Eu(III) ions. The newly synthesized luminescent materials offer many advantages, including the desired mechanical flexibility. They cannot be dissolved or fused, and so they have potential for use in optical and electronic applications. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Thiol-Ene Clickable Gelatin: A Platform Bioink for Multiple 3D Biofabrication Technologies.

    Science.gov (United States)

    Bertlein, Sarah; Brown, Gabriella; Lim, Khoon S; Jungst, Tomasz; Boeck, Thomas; Blunk, Torsten; Tessmar, Joerg; Hooper, Gary J; Woodfield, Tim B F; Groll, Juergen

    2017-11-01

    Bioprinting can be defined as the art of combining materials and cells to fabricate designed, hierarchical 3D hybrid constructs. Suitable materials, so called bioinks, have to comply with challenging rheological processing demands and rapidly form a stable hydrogel postprinting in a cytocompatible manner. Gelatin is often adopted for this purpose, usually modified with (meth-)acryloyl functionalities for postfabrication curing by free radical photopolymerization, resulting in a hydrogel that is cross-linked via nondegradable polymer chains of uncontrolled length. The application of allylated gelatin (GelAGE) as a thiol-ene clickable bioink for distinct biofabrication applications is reported. Curing of this system occurs via dimerization and yields a network with flexible properties that offer a wider biofabrication window than (meth-)acryloyl chemistry, and without additional nondegradable components. An in-depth analysis of GelAGE synthesis is conducted, and standard UV-initiation is further compared with a recently described visible-light-initiator system for GelAGE hydrogel formation. It is demonstrated that GelAGE may serve as a platform bioink for several biofabrication technologies by fabricating constructs with high shape fidelity via lithography-based (digital light processing) 3D printing and extrusion-based 3D bioprinting, the latter supporting long-term viability postprinting of encapsulated chondrocytes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Iron complexes of tetramine ligands catalyse allylic hydroxyamination via a nitroso–ene mechanism

    Directory of Open Access Journals (Sweden)

    David Porter

    2015-12-01

    Full Text Available Iron(II complexes of the tetradentate amines tris(2-pyridylmethylamine (TPA and N,N′-bis(2-pyridylmethyl-N,N′-dimethylethane-1,2-diamine (BPMEN are established catalysts of C–O bond formation, oxidising hydrocarbon substrates via hydroxylation, epoxidation and dihydroxylation pathways. Herein we report the capacity of these catalysts to promote C–N bond formation, via allylic amination of alkenes. The combination of N-Boc-hydroxylamine with either FeTPA (1 mol % or FeBPMEN (10 mol % converts cyclohexene to the allylic hydroxylamine (tert-butyl cyclohex-2-en-1-yl(hydroxycarbamate in moderate yields. Spectroscopic studies and trapping experiments suggest the reaction proceeds via a nitroso–ene mechanism, with involvement of a free N-Boc-nitroso intermediate. Asymmetric induction is not observed using the chiral tetramine ligand (+-(2R,2′R-1,1′-bis(2-pyridylmethyl-2,2′-bipyrrolidine ((R,R′-PDP.

  12. Oceanorium de Palos Verdes

    Directory of Open Access Journals (Sweden)

    Arquitectos Pereira y Luckman

    2017-05-01

    Full Text Available Publicado en el número 72 de INFORMES el conjunto de este proyecto, con el título de «Centro marítimo de turismo», en este artículo completamos su documentación con una exposición más detallada de las obras ya ejecutadas.

  13. Influencia de la topografía submarina sobre la distribución horizontal de las comunidades de ictioplancton en el entorno de la reserva marina de cabo de Palos - islas Hormigas (sudeste ibérico)

    OpenAIRE

    Vidal Peñas, I.; López Castejón, F.; Mas-Hernández, J. (Julio)

    2001-01-01

    The present study examines the relationships between the horizontal distribution of ichthyoplankton populations and submarine topography, in both neritic and oceanic waters of Cape Palos - Hormigas Islands Marine Reserve (southeast Spain). Larvae from self-spawners (Sardina pilchardus, Walbaum, 1792; Gobiidae and Sparidae) constituted the shallow community which dominated neritic waters, whereas larvae of Myctophidae (Benthosema glaciale, Reinhardt, 1837, and Lampanyctinae) constituted anothe...

  14. Photo-initiated thiol-ene click reactions as a potential strategy for incorporation of [M(I)(CO)3]+ (M = Re, (99m)Tc) complexes.

    Science.gov (United States)

    Hayes, Thomas R; Lyon, Patrice A; Silva-Lopez, Elsa; Twamley, Brendan; Benny, Paul D

    2013-03-18

    Click reactions offer a rapid technique to covalently assemble two molecules. In radiopharmaceutical construction, these reactions can be utilized to combine a radioactive metal complex with a biological targeting molecule to yield a potent tool for imaging or therapy applications. The photo-initiated radical thiol-ene click reaction between a thiol and an alkene was examined for the incorporation of [M(I)(CO)3](+) (M = Re, (99m)Tc) systems for conjugating biologically active targeting molecules containing a thiol. In this strategy, a potent chelate system, 2,2'-dipicolylamine (DPA), for [M(I)(CO)3](+) was functionalized at the central amine with a terminal alkene linker that was explored with two synthetic approaches, click then chelate and chelate then click, to determine the flexibility and applicability of the thiol-ene click reaction to specifically incorporate ligand systems and metal complexes with a thiol containing molecule. In the click then chelate approach, the thiol-ene click reaction was carried out with the DPA chelate followed by complexation with [M(I)(CO)3](+). In the chelate then click approach, the alkene functionalized DPA chelate was first complexed with [M(I)(CO)3](+) followed by the conduction of the thiol-ene click reaction. Initial studies utilized benzyl mercaptan as a model thiol for both strategies to generate the identical product from either route to provide information on reactivity and product formation. DPA ligands functionalized with two unique linker systems (allyl and propyl allyl ether) were prepared to examine the effect of the proximity of the chelate or complex on the thiol-ene click reaction. Both the thiol-ene click and coordination reactions with Re, (99m)Tc were performed in moderate to high yields demonstrating the potential of the thiol-ene click reaction for [M(I)(CO)3](+) incorporation into thiol containing biomolecules.

  15. Water and Energy Savings using Demand Hot Water Recirculating Systems in Residential Homes: A Case Study of Five Homes in Palo Alto, California

    Energy Technology Data Exchange (ETDEWEB)

    Ally, M.R.

    2002-11-14

    This report summarizes a preliminary study aimed at estimating the potential of saving potable water, (and the electrical energy used to heat it), that is presently lost directly to the drain while occupants wait for hot water to arrive at the faucet (point of use). Data were collected from five single-family homes in Palo Alto, California. Despite the small sample size in this study, the results make a compelling case for retrofitting homes with hot water recirculation systems to eliminate unnecessary wastage of water at the point of use. Technical as well as behavioral and attitudinal changes towards water conservation are necessary for a fulfilling and successful conservation effort. This report focuses on the technical issues, but behavioral issues are also noted, which may be factored into future studies involving local and state governments and utility companies.

  16. Interpretation of Pressure-Depth Data From Confined Underpressured Aquifers Exemplified by the Deep-Basin Brine Aquifer, Palo Duro Basin, Texas

    Science.gov (United States)

    Orr, Elizabeth D.; Kreitler, Charles W.

    1985-04-01

    Investigations of underpressured aquifers can be improved by accounting for factors that impede accurate interpretation of pressure-depth plots. Poor data quality and distribution obscure true pressure-depth trends. Plotted data may also be distorted by the hydrogeologic setting, i.e., the surface topography, the structural dip of the aquifer, and the potentiometric surface. In the Palo Duro Basin in the Texas Panhandle, distortions caused by the hydrogeologic setting are reduced by delineating regions having little variation in surface topography and in structural dip of the aquifer. Pressure-depth plots for these regions vary considerably. The effects of the hydrogeologic setting on these plots were evaluated by computing pressure-depth data for flow parallel to the structural dip of the aquifer in each region. By comparing regression lines through real pressure-depth data with those through computed data, true hydrologic conditions could be distinguished from the misleading effects of the hydrogeologic setting on pressure-depth plots.

  17. Interpretation of pressure-depth data from confined underpressured aquifers exemplified by the Deep-Basin Brine aquifer, Palo Duro Basin, Texas

    Energy Technology Data Exchange (ETDEWEB)

    Orr, E.D.; Kreitler, C.W.

    1985-04-01

    Investigations of underpressure aquifers can be improved by accounting for factors that impede accurate interpretation of pressure-depth plots. Poor data quality and distribution obscure true pressure-depth trends. Plotted data may also be distorted by the hydrogeologic setting, i.e., the surface topography, the structural dip of the aquifer, and the potentiometric surface. In the Palo Duro Basin in the Texas Panhandle, distortions caused by the hydrogeologic setting are reduced by delineating regions having little variations in surface topography and in structural dip of the aquifer. Pressure-depth plots for these regions vary considerably. The effects of the hydrogeologic setting on these plots were evaluated by computing pressure-depth data for flow parallel to the structural dip of the aquifer in each region. By comparing regression lines through real pressure-depth data with those through computed data, true hydrologic conditions could be distinguished from the misleading effects of the hydrogeologic setting on pressure-depth plots.

  18. Numerical modeling of regional ground-water flow in the deep-basin brine aquifer of the Palo Duro Basin, Texas Panhandle

    Energy Technology Data Exchange (ETDEWEB)

    Wirojanagud, P.; Kreitler, C.W.; Smith, D.A.

    1986-01-01

    Bedded Permian-age evaporite sequences in the Palo Duro Basin are being considered for a permanent nuclear waste repository by the U.S. Department of Energy. The purpose of this modeling study is to provide an understanding of regional ground-water flow in the formations beneath the Permian evaporite section. From this understanding, more detailed, smaller scale studies can be designed. This study is also intended to provide a better understanding of the boundary conditions and permeabilities of the aquifer and aquitard system as well as provide estimates of ground-water travel times across the basin. Numerical simulations were made of the Wolfcamp aquifer modeled as a single layer and of the entire Deep-Basin Brine aquifer system, including the Wolfcamp aquifer, modeled as a single layer.

  19. C27-C30 neohop-13(18)-enes and their saturated and aromatic derivatives in sediments: Indicators for diagenesis and water column stratification

    Science.gov (United States)

    Sinninghe Damsté, Jaap S.; Schouten, Stefan; Volkman, John K.

    2014-05-01

    A limited suite of C27, C29 and C30 rearranged hopenes identified as neohop-13(18)-enes have been reported in immature Recent and ancient marine/lacustrine sediments and their presence has been explained by dehydration and isomerisation of ubiquitous hopanols or hopenes. Here we investigated the source and fate of neohop-13(18)-enes in a range of Recent and ancient sediments. The analysis of δ13C values of hop-17(21)-ene and neohop-13(18)-ene in Arabian Sea surface sediments, in the Monterey Formation and in immature Cenomanian black shales show that they differ by 2-3‰, suggesting that the C30 neohop-13(18)-ene has a source different from those of the non-rearranged C30 hopenes. A new member of the family of neohop-13(18)-enes, the C28 hopene 28,30-dinorhop-13(18)-ene, was identified based on comparison of its mass spectral data with that of other members of the family of neohopenes. Its occurrence explains the formation of a series of orphan aromatic hopanoids bearing an ethyl group at C-21, known to occur in high concentrations in some organic-rich ancient sediments. Circumstantial evidence for this formation pathway is provided by identical δ13C values for the C28 28,30-dinorhop-13(18)-ene and two aromatic hopanoids in two Cretaceous black shales. Relatively abundant C28 28,30-dinorhopene and related aromatic derivatives were present in ancient sediments where the distribution of other biomarkers (i.e. isorenieratene derivatives) indicated a stratified palaeo water column. Therefore, it is suggested that these compounds are derived from bacteria dwelling at or below the chemocline and may be used as indicators of stratified water bodies in the past. 28,30-Dinorhop-13(18)-ene may also be a precursor of the unusual C28 desmethylhopane 28,30-dinorhopane found in high concentrations in anoxic sediments and a limited suite of crude oils, which is consistent with the proposal that it too ultimately derives from bacteria living at the oxic-anoxic interface.

  20. Synthesis and Transformations of di-endo-3-Aminobicyclo-[2.2.2]oct-5-ene-2-carboxylic Acid Derivatives

    Directory of Open Access Journals (Sweden)

    Márta Palkó

    2011-09-01

    Full Text Available all-endo-3-amino-5-hydroxybicyclo[2.2.2]octane-2-carboxylic acid (13 and all-endo-5-amino-6-(hydroxymethylbicyclo[2.2.2]octan-2-ol (10 were prepared via dihydro-1,3-oxazine or g-lactone intermediates by the stereoselective functionalization of an N-protected derivative of endo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acid (2. Ring closure of b-amino ester 4 resulted in tricyclic pyrimidinones 15 and 16. The structures, stereochemistry and relative configurations of the synthesized compounds were determined by IR and NMR.

  1. Vabariigi presidendi, riigikogu esimehe ja peaministri ühisavaldus 8. mail 2007 / Toomas Hendrik Ilves, Ene Ergma, Andrus Ansip

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2007-01-01

    President Toomas Hendrik Ilvese, Riigikogu spiikri Ene Ergma ja peaminister Andrus Ansipi avaldus Teise maailmasõja lõpu 62. aastapäeva puhul. Ilmunud ka: Severnoje Poberežje 9. mai 2007, lk. 2; Eesti Elu 11. mai 2007, lk. 2, pealk.: Riigijuhtide ühisavaldus Teise maailmasõja mälestuspäeval, ingl. k. lk. 11, pealk.: Joint statement May 8, 2007; ingl. k. Vaba Eesti Sõna 10. mai 2007, lk. 12, pealk.: Joint statement of the President, Speaker of the Parliament and Prime Minister of the Republic of Estonia

  2. Thiol-ene and photo-cleavage chemistry for controlled presentation of biomolecules in hydrogels.

    Science.gov (United States)

    Grim, Joseph C; Marozas, Ian A; Anseth, Kristi S

    2015-12-10

    photochemical methods have led to important advances in the tissue regeneration community, namely the thiol-ene photo-click reaction for bioconjugation and photocleavage reactions that allow for the removal of protecting groups. Specific examples will be highlighted where these methodologies have been used to engineer hydrogels that control and direct cell function with the aim of inspiring their use in regenerative medicine. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Currents, temperature, conductivity, attenuation, sigma-theta, and wave statistics data from moorings deployed off the coast of Palos Verdes, CA from platforms ROBERT GORDON SPROUL, YELLOWFIN, and SEA WATCH from December 3, 2007 to April 29, 2008 (NODC Accession 0067575)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Palos Verdes shelf near Los Angeles is contaminated with DDT and PCBs discharged through the White Point ocean outfalls, mostly prior to 1971. The U. S....

  4. Currents, wind speed, wind direction, temperature, attenuation, conductivity, and sigma-theta data from moorings deployed off the coast of Palos Verdes, CA from platforms ROBERT GORDON SPROUL, SEAWATCH, and YELLOWFIN from February 15, 2004 to July 8, 2004 (NODC Accession 0067574)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Palos Verdes shelf near Los Angeles is contaminated with DDT and PCBs discharged through the White Point ocean outfalls, mostly prior to 1971. The U. S....

  5. A neutral polyacrylate copolymer coating for surface modification of thiol-ene microchannels for improved performance of protein separation by microchip electrophoresis

    DEFF Research Database (Denmark)

    Mesbah, Kiarach; Mai, T.D.; Jensen, Thomas Glasdam

    2016-01-01

    We have investigated the behavior of thiol-ene substrates that is a class of promising materials for lab-on-a-chip electrophoresis applications. Two polymeric materials were prepared by copolymerization of N, N-dimethylacrylamide (DMA), (3-(methacryloyl-oxy)propyl)trimethoxysilane (PMA) and 3......-(DMA-PMAMAPS) copolymer were evaluated in terms of surface hydrophilicity, suppression and stability of electro-osmotic flow and prevention of protein adsorption. Surface modification of thiol-ene containing a 20 % excess of thiols with the terpolymer p-(DMA-PMA-MAPS) was found to offer the most stable coating and most...

  6. [Preparation of organic-inorganic hybrid boronate affinity monolith via thiol-ene click reaction for specific capture of glycoproteins].

    Science.gov (United States)

    Yang, Fan; Mao, Jie; He, Xiwen; Chen, Langxing; Zhang, Yukui

    2013-06-01

    A novel strategy for the preparation of the organic-inorganic hybrid boronate affinity monolith was developed via the "thiol-ene" click reaction. A thiol group-modified silica monolith was first synthesized via the sol-gel process by the in situ co-condensation with tetramethoxysilane (TMOS) and 3-mercaptopropyltrimethoxysilane (MPTMS) as precursors. Then 3-acrylamidophenylboronic acid (AAPBA) was covalently immobilized on the hybrid monolith via the "thiol-ene" click reaction to form AAPBA-silica hybrid affinity monolith. The reaction conditions for the preparation of AAPBA-silica hybrid affinity monolith were optimized, including the ratio of TMOS to MPTMS, the contents of poly(ethylene glycol) (PEG) and methanol. The morphology and mechanical stability of the boronate affinity monolith were characterized and evaluated by scanning electron microscopy and Fourier-transform infrared spectroscopy. The obtained boronate affinity hybrid monolith exhibited excellent specificity toward the nucleosides containing cis-diols under neutral conditions. It was further applied to the specific capture of the glycoproteins ovalbumin and horseradish peroxidase. The method is novel and reliable, which has a great potential for the preparation of different kinds of the boronate affinity monoliths.

  7. One-pot preparation of an organic polymer monolith by thiol-ene click chemistry for capillary electrochromatography.

    Science.gov (United States)

    Wang, Jiannan; Shen, Shufen; Lu, Xin; Ye, Fanggui

    2017-08-01

    A novel organic monolith was successfully fabricated by a one-pot thiol-ene click reaction of triallyl isocyanurate with pentaerythritol tetrakis-(2-mercaptoacetate) and mercaptopropionic acid in the presence of porogens. We investigated the effects of the ratio of monomer and cross-linking agent, the type and ratio of porogen, and click reaction temperature on the permeability and morphology of the prepared poly triallyl isocyanurate-co-pentaerythritol tetrakis (2-mercaptoacetate) monoliths. The monolith was also characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The results indicated that the monoliths had continuous porous framework, good permeability, and high mechanical stability. A series of analytes with different properties such as alkylbenzenes, polycyclic aromatic hydrocarbons, anilines, and phenols were used to evaluate the electrochromatographic performance of the prepared monoliths in pressurized capillary electrochromatography. The prepared polymer monolith showed typical reversed-phase electrochromatographic behavior for hydrophobic substances. Moreover, the prepared monolith showed a mix of reversed-phase and cation exchange interaction modes for basic aniline compounds. The minimum plate height of the monolith was 8.76 μm (132 100 plates/m) for propylbenzene. These results demonstrated that one-pot thiol-ene click chemistry can provide a simple and reliable method for the preparation of organic monoliths. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. A colorimetric detection of acrylamide in potato chips based on nucleophile-initiated thiol-ene Michael addition.

    Science.gov (United States)

    Hu, Qinqin; Fu, Yingchun; Xu, Xiahong; Qiao, Zhaohui; Wang, Ronghui; Zhang, Ying; Li, Yanbin

    2016-02-07

    Acrylamide (AA), a neurotoxin and a potential carcinogen, has been found in various thermally processed foods such as potato chips, biscuits, and coffee. Simple, cost-effective, and sensitive methods for the rapid detection of AA are needed to ensure food safety. Herein, a novel colorimetric method was proposed for the visual detection of AA based on a nucleophile-initiated thiol-ene Michael addition reaction. Gold nanoparticles (AuNPs) were aggregated by glutathione (GSH) because of a ligand-replacement, accompanied by a color change from red to purple. In the presence of AA, after the thiol-ene Michael addition reaction between GSH and AA with the catalysis of a nucleophile, the sulfhydryl group of GSH was consumed by AA, which hindered the subsequent ligand-replacement and the aggregation of AuNPs. Therefore, the concentration of AA could be determined by the visible color change caused by dispersion/aggregation of AuNPs. This new method showed high sensitivity with a linear range from 0.1 μmol L(-1) to 80 μmol L(-1) and a detection limit of 28.6 nmol L(-1), and especially revealed better selectivity than the fluorescence sensing method reported previously. Moreover, this new method was used to detect AA in potato chips with a satisfactory result in comparison with the standard methods based on chromatography, which indicated that the colorimetric method can be expanded for the rapid detection of AA in thermally processed foods.

  9. Synthesis of antibacterial amphiphilic elastomer based on polystyrene-block-polyisoprene-block-polystyrene via thiol-ene addition

    Energy Technology Data Exchange (ETDEWEB)

    Keleş, Elif, E-mail: elifkelesh@hotmail.com [Department of Chemistry, Bülent Ecevit University, Zonguldak 67100 (Turkey); Hazer, Baki, E-mail: bhazer2@yahoo.com [Department of Chemistry, Bülent Ecevit University, Zonguldak 67100 (Turkey); Cömert, Füsun B. [Department of Microbiology, Faculty of Medicine, Bülent Ecevit University, 67600 Zonguldak (Turkey)

    2013-04-01

    A new type of amphiphilic antibacterial elastomer has been described. Thermoplastic elastomer, polystyrene–block-polyisoprene–block-polystyrene (PS–b-PI–b-PS) triblock copolymer was functionalized in toluene solution by free radical mercaptan addition in order to obtain an amphiphilic antibacterial elastomer. Thiol terminated PEG was grafted through the double bonds of PS–b-PI–b-PS via free radical thiol-ene coupling reaction. The antibacterial properties of the amphiphilic graft copolymers were observed. The original and the modified polymers were used to create microfibers in an electro-spinning process. Topology of the electrospun micro/nanofibers were studied by using scanning electron microscopy (SEM). The chemical structures of the amphiphilic comb type graft copolymers were elucidated by the combination of elemental analysis, {sup 1}H NMR, {sup 13}C NMR, GPC and FTIR. - Graphical abstract: Double bonds of polyisoprene units in polystyrene–block-polyisoprene–block-polystyrene triblock copolymer were partially capped with PEG containing mercapto end group via thiol-ene addition in order to obtain antibacterial amphiphilic elastomer. Nano fibers from amphiphilic graft polymers solution were produced by electrospinning. The PEG grafted copolymer inhibits very effectively bacterial growth. Highlights: ► A commercial synthetic elastomer was grafted with PEG to obtain amphiphilic elastomer. ► Amphiphilic elastomer shows antibacterial properties. ► Electrospun micro fibers of the amphiphilic elastomer tend to globular formation.

  10. Functional characterization and stability improvement of a ‘thermophilic-like’ ene-reductase from Rhodococcus opacus 1CP

    Directory of Open Access Journals (Sweden)

    Anika eRiedel

    2015-10-01

    Full Text Available Ene-reductases are widely applied for the asymmetric synthesis of relevant industrial chemicals. A novel ene-reductase OYERo2 was found within a set of 14 putative Old Yellow Enzymes (OYEs obtained by genome mining of the actinobacterium Rhodococcus opacus 1CP. Multiple sequence alignment suggested that the enzyme belongs to the group of ‘thermophilic-like’ OYEs. OYERo2 was produced in Escherichia coli and biochemically characterized. The enzyme is strongly NADPH dependent and uses non-covalently bound FMNH2 for the reduction of activated α,β-unsaturated alkenes. In the active form OYERo2 is a dimer. Optimal catalysis occurs at pH 7.3 and 37 °C. OYERo2 showed highest specific activities (4550 U mg-1 on maleimides, which are efficiently converted to the corresponding succinimides. The OYERo2-mediated reduction of prochiral alkenes afforded the (R-products with excellent optical purity (ee > 99%. OYERo2 is not as thermo-resistant as related OYEs. Introduction of a characteristic intermolecular salt bridge by site-specific mutagenesis raised the half-life of enzyme inactivation at 32 °C from 28 min to 87 min and improved the tolerance towards organic co-solvents. The suitability of OYERo2 for application in industrial biocatalysis is discussed.

  11. Statistical effects in the thermal deazetization reaction of 2,3-diazabicyclo(2.2.1)hept-2-ene

    Science.gov (United States)

    Sorescu, Dan C.; Thompson, Donald L.; Raff, Lionel M.

    1995-10-01

    The deazetization reaction of 2,3-diazabicyclo(2.2.1)hept-2-ene-exo, exo-5,6-d2 is investigated using Monte Carlo classical variational transition-state theory, implemented by the efficient microcanonical sampling procedure. Comparison is made with the results of trajectory calculations performed on the same global potential-energy surface. The microcanonical reaction rates have been determined for both reaction channels, i.e., the stepwise and concerted cleavage of the two C-N bonds of the reactant. The results demonstrate that the thermal decomposition of 2,3-diazabicyclo (2.2.1)hept-2-ene-exo,exo-5,6-d2 is well described by statistical theories that assume equal weighting for all energetically accessible phase-space points. It is found that the rate coefficients of the statistical calculations are close upper bounds of the rates determined in trajectory calculations. Previously reported classical trajectory simulations have shown that the distribution of internal energy in the reactant configuration, at the transition state and beyond is very nearly microcanonical for the range of excitation energies analyzed (60-175 kcal/mol). Under such conditions, the agreement obtained between the present statistically computed rate coefficients and those extracted from the trajectory results is not surprising. It is suggested that nonstatistical post-transition-state events account for the nonunity ratio of the exo/endo reaction products observed experimentally. These events are not considered in the present statistical theories of the reaction rates.

  12. Geologic map of the Palo Alto and part of the Redwood Point 7-1/2' quadrangles, San Mateo and Santa Clara counties, California

    Science.gov (United States)

    Pampeyan, Earl H.

    1993-01-01

    The Palo Alto and southern part of the Redwood Point 7-1/2' quadrangles cover an area on the San Francisco peninsula between San Francisco Bay and the Santa Cruz Mountains. San Francisquito and Los Trancos Creeks, in the southeastern part of the map area, form the boundary between San Mateo and Santa Clara Counties. The area covered by the geologic map extends from tidal and marsh lands at the edge of the bay southward across a gently sloping alluvial plain to the foothills of the northern Santa Cruz Mountains. The foothills are separated from the main mass of the mountains by two northwest-striking faults, the San Andreas and Pilarcitos, that cross the southwest corner of the map area (fig. 1). The map and adjoining areas are here divided into three structural blocks juxtaposed along these faults, adopting the scheme of Nilsen and Brabb (1979): (1) the San Francisco Bay block lying east of the San Andreas Fault Zone; (2) the Pilarcitos block lying between the San Andreas and Pilarcitos Faults; and (3) the La Honda block that includes the main mass of the Santa Cruz Mountains lying west of the Pilarcitos Fault. The west boundary of the La Honda block is the Seal Cove-San Gregorio Fault. Pre-late Pleistocene Cenozoic rocks of the foothills have been compressed into northwest-striking folds, which have been overridden by Mesozoic rocks along southwest-dipping low-angle faults. Coarse- to fine-grained upper Pleistocene and Holocene alluvial and estuarine deposits, eroded from the foothills and composing the alluvial plain, are essentially undeformed. Most of the alluvial plain, including some parts of the marsh land that borders the bay, has been covered by residential and commercial developments, and virtually all of the remaining marsh land has been diked off and used as salt evaporating ponds. The map area includes parts of the municipalities of San Carlos, Redwood City, Atherton, Woodside, Portola Valley, Menlo Park, and East Palo Alto in San Mateo County; and

  13. Molecular structure and conformations of 1-methoxy-2,3,3,4,4-pentafluorocyclobut-1-ene

    Science.gov (United States)

    Frogner, Matthew; Hedberg, Kenneth; Hedberg, Lise; Lunelli, Bruno

    2010-08-01

    The structure of 1-monomethoxy-2,3,3,4,4-pentafluorocyclobut-1-ene (F5MCB) has been studied as a part of a series of investigations of the structures of substituted cyclobutenes. The experimental method was gas-phase electron diffraction (GED) augmented by molecular orbital calculations at the HF and B3LYP levels of theory with basis sets 6-31G(d), 6-311+G(3df,2p), and cc-pvtZ. The matter of most interest in these compounds is the length of the C3-C4 bond, which has been found to be significantly longer than the corresponding bond in cyclobutene itself when both ligands to the double bond are fluorine or chlorine atoms, but about the same as in cyclobutene when both substituents are methoxy groups. This result has been verified by the additional data provided by this study of F5MCB: the C3-C4 bond is about the same as in the dimethoxy compound and in cyclobutene. In the gas-phase at 25 °C, F5MCB exists as a mixture of two conformers, one with the methyl group cis to the double bond (about 70%) and one with it trans (about 30%), in good agreement with theory that predicts 63-70% cis. Some values (with estimated 2 σ uncertainties) of the more important parameters ( rg/Å; ∠ α/°) are for the cis/ trans forms r() = 1.101 (17)/1.121, r(C dbnd C) = 1.329 (36)/1.328, r(C1-C4) = 1.498 (19)/1.504, r(C2-C3) = 1.483 (19)/1.485, r(C3-C4) = 1.581 (21)/1.576, r(C2-F6)=1.346 (12)/1.339, r(C3-F7) = 1.347 (10)/1.349, r(C4-F9) = 1.344 (10)/1.350, r(C1-O5) = 1.337 (26)/1.343, r(O5-C11) = 1.469 (37)/1.493, ∠(C4C1C2) = 93.3 (8)/93.1, ∠(C1C2C3) = 96.4 (8)/96.6, ∠(C2C3C4) = 84.4 (8)/84.4, ∠(C3C4C1) = 85.0 (9)/85.9, ∠(C2C1O5) = 141.0 (14)/135.2, ∠(C1C2F6) = 135.4 (14)/135.1, ∠(C1O5C11) = 117.3 (33)/117.8, ∠(F9C4F10) = 108.3 (13)/107.7, ∠(F7C3F8) = 107.7 (13)/107.6, ∠(XC4C3) = 134.4 (15)/134.4, and ∠(X'C3C4) = 134.2 (15)/133.9, where X and X' are, respectively, the bisectors of the F9C4F10 and F7C3F8 angles. The structure is discussed with reference to the

  14. Combining ring-opening metathesis polymerization and thiol-ene coupling chemistries: facile access to novel functional linear and nonlinear macromolecules.

    Science.gov (United States)

    Lowe, Andrew B; Liu, Meina; van Hensbergen, Johannes Arend; Burford, Robert P

    2014-02-01

    The aim of this article is to highlight recent examples in which two powerful synthetic tools, namely ring-opening metathesis polymerization (ROMP) and thiol-ene (including the thiol-Michael variant) click chemistry have been combined to facilitate the preparation of novel functional materials of varying topology. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp.

    Science.gov (United States)

    Asami, Yukihiro; Kakeya, Hideaki; Onose, Rie; Yoshida, Arika; Matsuzaki, Hiroshi; Osada, Hiroyuki

    2002-08-22

    [structure: see text] Azaspirene isolated from the fungus Neosartorya sp. is a novel angiogenesis inhibitor with a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton. Azaspirene inhibits the endothelial migration induced by vascular endothelial growth factor (ED100 = 27.1 microM).

  16. N-(3,4-Dimethoxyphenyl-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-1-carboxamide Hydrochloride

    Directory of Open Access Journals (Sweden)

    Seranthimata Samshuddin

    2012-08-01

    Full Text Available A simple and novel route for synthesis of new spirocyclic amide derivative is developed. The present work involves the oxidative cleavage of tert-butyl 1-(furan-2-yl-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-7-carboxylate 1 followed by the amine coupling and deprotection of Boc.

  17. Noorsootöö Keskusel täitub kümnes tegevusaasta / Edgar Schlümmer ; kommenteerinud Irma Toodo, Ene Raid, Andres Lokk

    Index Scriptorium Estoniae

    Schlümmer, Edgar

    2009-01-01

    Eesti Noorsootöö Keskus (ENTK)tähistab kümnendat sünnipäeva. ENTK rolli tänapäeva noorsootöös kommenteerivad endine ENTK töötaja Irma Toodo ja praegused töötajad Ene Raid ning Andres Lokk

  18. Ene-Liis Semper: selle aasta puhkepäevad võib ühe käe sõrmedel kokku lugeda

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2011-01-01

    Tallinna kultuuripealinna projekti panustanud Ene-Liis Semper võtab 2011. aasta sündmused kokku ja selgitab, kuidas jõudsid publiku ette suurlavastused "The Rise and Fall of Estonia", "Three Kingdoms", Põhuteater ning isikunäitus Kumus

  19. (E-2-((4R,5R-5-((Benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-ylbut-2-ene-1,4-diol

    Directory of Open Access Journals (Sweden)

    Carlos R. Carreras

    2010-04-01

    Full Text Available The synthesis of (E-2-((4R,5R-5-((benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-ylbut-2-ene-1,4-diol by a one-step reduction of the appropriate 2-substituted butenolide is reported. Product characterization was carried out by IR, 1H NMR, 13C NMR, MS, elemental analysis and optical rotation.

  20. Joint statement of the President, Speaker of the Riigikogu and Prime Minister of the Republic of Estonia / Toomas Hendrik Ilves, Ene Ergma, Andrus Ansip

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    President Toomas Hendrik Ilvese, Riigikogu spiikri Ene Ergma ja peaminister Andrus Ansipi ühisavaldus Teise maailmasõja lõpu 62. aastapäeva puhul 8. mail 2007, milles kinnitatakse, et hoolimata Teise maailmasõja ajaloolistest tõlgendustest on kõik Eestis elavad inimesed vabad ning jagavad ühist tulevikku

  1. Broadening the scope of Baeyer-Villiger monooxygenase activities toward α,β-unsaturated ketones: a promising route to chiral enol-lactones and ene-lactones.

    Science.gov (United States)

    Reignier, T; de Berardinis, V; Petit, J-L; Mariage, A; Hamzé, K; Duquesne, K; Alphand, V

    2014-07-25

    Three regiodivergent Baeyer-Villiger mono-oxygenases (enantioselectively) oxidized a series of cyclic α,β-unsaturated ketones into (chiral) either enol-lactones or ene-lactones. An easy-to-use and efficient biocatalytic process based on a host-microorganism deprived of unwanted activities (knock-out mutant) was developed to enable the exclusive synthesis of unsaturated lactones.

  2. C27-C30 neohop-13(18)-enes and their saturated and aromatic derivatives in sediments: Indicators for diagenesis and water column stratification

    NARCIS (Netherlands)

    Sinninghe Damsté, J.S.; Schouten, S.; Volkman, J.K.

    2014-01-01

    A limited suite of C27, C29 and C30 rearranged hopenes identified as neohop-13(18)-enes have been reported in immature Recent and ancient marine/lacustrine sediments and their presence has been explained by dehydration and isomerisation of ubiquitous hopanols or hopenes. Here we investigated the

  3. Records of continental slope sediment flow morphodynamic responses to gradient and active faulting from integrated AUV and ROV data, offshore Palos Verdes, southern California Borderland

    Science.gov (United States)

    Maier, Katherine L.; Brothers, Daniel; Paull, Charles K.; McGann, Mary; Caress, David W.; Conrad, James E.

    2016-01-01

    Variations in seabed gradient are widely acknowledged to influence deep-water deposition, but are often difficult to measure in sufficient detail from both modern and ancient examples. On the continental slope offshore Los Angeles, California, autonomous underwater vehicle, remotely operated vehicle, and shipboard methods were used to collect a dense grid of high-resolution multibeam bathymetry, chirp sub-bottom profiles, and targeted sediment core samples that demonstrate the influence of seafloor gradient on sediment accumulation, depositional environment, grain size of deposits, and seafloor morphology. In this setting, restraining and releasing bends along the active right-lateral Palos Verdes Fault create and maintain variations in seafloor gradient. Holocene down-slope flows appear to have been generated by slope failure, primarily on the uppermost slope (~ 100–200 m water depth). Turbidity currents created a low relief (sediment waves (λ = ~ 100 m, h ≤ 2 m), and a series of depocenters that have accumulated up to 4 m of Holocene sediment. Sediment waves increase in wavelength and decrease in wave height with decreasing gradient. Integrated analysis of high-resolution datasets provides quantification of morphodynamic sensitivity to seafloor gradients acting throughout deep-water depositional systems. These results help to bridge gaps in scale between existing deep-sea and experimental datasets and may provide constraints for future numerical modeling studies.

  4. Características tecnológicas de la madera de palo morado (Peltogyne mexicana Martínez de tierra colorada, Guerrero, México

    Directory of Open Access Journals (Sweden)

    J. Navarro-Martínez

    2005-01-01

    Full Text Available El presente trabajo contribuye al conocimiento de las características y propiedades tecnológicas de la madera de Palo morado (Peltogyne mexicana Martínez, mediante la caracterización anatómica, porcentaje de elementos y determinación de las propiedades físicas y tres mecánicas. Se colectaron dos árboles en Tierra Colorada Guerrero. El material se obtuvo de trozas a 1.30 m de altura. Para el estudio macroscópico se usaron muestras de 7 x 15 x 1 cm y para el microscópico se elaboraron preparaciones fijas de cortes y de material disociado. La madera presenta un color violeta intenso, porosidad difusa, parénquima en bandas y aliforme confluente con cristales, los elementos de vaso son cortos de diámetro medio, con inclusiones, rayos uniseriados, biseriados, triseriados y raramente multiseriados; las fibras son de tipo libriforme de longitud media, diámetro fino y pared gruesa, presenta densidad básica, contracciones y dureza alta.

  5. 1,25-(OH)2-16ene-23yne-D3 reduces secondary hyperparathyroidism in uremic rats with little calcemic effect.

    Science.gov (United States)

    Lippuner, Kurt; Perrelet, Romain; Casez, Jean-Paul; Popp, Albrecht; Uskokovic, Milan R; Jaeger, Philippe

    2004-01-01

    To compare the effects of vitamin D analogs versus calcitriol on serum levels of Ca, P and parathyroid hormone (PTH). A compound better than calcitriol should increase the Ca x P product less than calcitriol for an equivalent decrease in PTH levels. Biological activity of 4 vitamin D analogs, 1,25-(OH)(2)-16ene- D(3) (RO(1)), 1,25-(OH)(2)-16ene-23yne-D(3) (RO(2)), 1,25-(OH)(2)-26,27-hexafluoro-16ene-23yne-D(3) (RO(3)) and 1,25-(OH)(2)-16ene-23yne-26,27-hexafluoro-19nor-D(3) (RO(4)) was tested vs. calcitriol in parathyroidectomized rats. In a second set of experiments, the effects of RO(2), RO(4) and calcitriol were studied in 5/6 nephrectomized rats with secondary hyperparathyroidism. In parathyroidectomized rats, all analogs (250 pmol/day) led calcemia to rise after 7 days. In uremic rats, all treatments reduced PTH levels. RO(4) revealed toxicity. RO(2) was as effective as calcitriol in suppressing PTH in a dose dependent manner. Mean plasma ionized calcium did not change from baseline to day 14 and day 28 on RO(2) (250 or 500 pmol/day) whereas it increased significantly on RO(2) (1,000 pmol/day) and calcitriol (125 or 250 pmol/day). Increasing the dose of calcitriol led Ca x P to rise more dramatically than increasing the dose of RO(2), which appears to have a wider therapeutic window than calcitriol. 1,25-(OH)(2)-16ene-23yne-D(3) (RO(2)) may represent a novel candidate for the treatment of renal osteodystrophy in humans. Copyright 2004 S. Karger AG, Basel

  6. Synthesis and preliminary bioevaluation of 99mTc(CO)3-17α-triazolylandrost-4-ene-3-one derivative prepared via click chemistry route.

    Science.gov (United States)

    Dhyani, Manish V; Satpati, Drishty; Korde, Aruna; Banerjee, Sharmila

    2011-10-01

    Azolyl steroids are known to manifest antiprostate cancer and antiandrogenic activities. These azolyl steroids have been shown to express affinity toward androgen receptors (ARs) overexpressed on LNCaP (human prostate adenocarcinoma) cell line. Hence, suitably derivatized azolyl steroids can be envisaged as potential vectors for targeting overexpression of ARs in prostate cancer. In the present study, testosterone has been derivatized to 17α-azidoandrost-4-ene-3-one using microwave-mediated azidation of the mesylate. Subsequently, a facile one-pot Cu(I)-catalyzed Click reaction was carried out to synthesize (99m)Tc(CO)(3)-labeled 17α-triazolylandrost-4-ene-3-one, which was characterized by HPLC. The chemical characterization of (99m)Tc(CO)(3)-17α-triazolylandrost-4-ene-3-one was carried out by preparing its corresponding rhenium complex using [NEt(4)](2)[Re(CO)(3)Br(3)] precursor. The radiolabeled complex could be prepared in >95% radiochemical yield as determined by HPLC. In vitro studies of (99m)Tc(CO)(3)-17α-triazolylandrost-4-ene-3-one complex in LNCaP cell lines overexpressing ARs showed binding of 4.95%±1.2%, with inhibition of 8%±0.9%. In vivo biodistribution studies in male Wistar rats have shown uptake in the prostate to the extent of 0.48%±0.19% injected dose/g at 1 hpi and retention therein till 3 hpi. The present study demonstrates a novel and facile one-pot reaction for preparation of (99m)Tc-labeled 17α-triazolylandrost-4-ene-3-one complex using Click chemistry. The corresponding Re-analog has been prepared for purpose of comparative characterization with the (99m)Tc-labeled complex. The radiosynthetic strategy described in this article can be further extended toward preparation of radiolabeled complexes of other triazolyl steroidal derivatives.

  7. The preparation and physical properties of polysulfide-based elastomers through one-pot thiol-ene click reaction

    Directory of Open Access Journals (Sweden)

    Y. W. Quan

    2013-07-01

    Full Text Available In this paper, polysulfide-based elastomers were successfully prepared through a simple one-pot thiol-ene click reaction of the liquid polysulfide oligomer with bisphenol-A diacrylate resin. Real-time Fourier transform infrared spectroscopy (FTIR analysis showed that the molecular weight of the liquid polysulfide oligomer had no effect on mercaptan functional group conversion. The obtained elastomers continued to keep low temperature flexibility of polysulfide except Elastomer-LP3, which was due to higher content of bisphenol-A structure. All the samples had a tensile strength of over 0.7 MPa, which was comparable to that of polysulfide polymer cured by metal oxide. Moreover, the samples exhibited higher thermal stability than metal oxide cured polysulfide. This vulcanization methodology will provide a fast, efficient, and environmentally friendly approach (without metal oxides and plasticizers for preparing polysulfide elastomers.

  8. Modifying surface resistivity and liquid moisture management property of keratin fibers through thiol-ene click reactions.

    Science.gov (United States)

    Yu, Dan; Cai, Jackie Y; Church, Jeffrey S; Wang, Lijing

    2014-01-22

    This paper reports on a new method for improving the antistatic and liquid moisture management properties of keratinous materials. The method involves the generation of thiols by controlled reduction of cystine disulfide bonds in keratin with tris(2-carboxyethyl) phosphine hydrochloride and subsequent grafting of hydrophilic groups onto the reduced keratin by reaction with an acrylate sulfonate or acrylamide sulfonate through thiol-ene click chemistry. The modified substrates were characterized with Raman spectroscopy and scanning electron microscopy and evaluated for their performance changes in liquid moisture management, surface resistivity, and wet burst strength. The results have revealed that the thiol-acrylate reaction is more efficient than the thiol-acrylamide reaction, and the keratinous substrate modified with an acrylate sulfonate salt exhibits significantly improved antistatic and liquid moisture management properties.

  9. Preparation of a novel carboxyl stationary phase by "thiol-ene" click chemistry for hydrophilic interaction chromatography.

    Science.gov (United States)

    Peng, Xi-Tian; Liu, Tao; Ji, Shu-Xian; Feng, Yu-Qi

    2013-08-01

    A novel carboxyl-bonded silica stationary phase was prepared by "thiol-ene" click chemistry. The resultant Thiol-Click-COOH phase was evaluated under hydrophilic interaction liquid chromatography (HILIC) mobile phase conditions. A comparison of the chromatographic performance of Thiol-Click-COOH and pure silica columns was performed according to the retention behaviors of analytes and the charged state of the stationary phases. The results indicated that the newly developed Thiol-Click-COOH column has a higher surface charge and stronger hydrophilicity than the pure silica column. Furthermore, the chromatographic behaviors of five nucleosides on the Thiol-Click-COOH phase were investigated in detail. Finally, a good separation of 13 nucleosides and bases, and four water-soluble vitamins was achieved. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Orthogonal dual thiol–chloroacetyl and thiol–ene couplings for the sequential one-pot assembly of heteroglycoclusters

    Directory of Open Access Journals (Sweden)

    Michele Fiore

    2014-07-01

    Full Text Available We describe the first one-pot orthogonal strategy to prepare well-defined cyclopeptide-based heteroglycoclusters (hGCs from glycosyl thiols. Both thiol–chloroactetyl coupling (TCC and thiol–ene coupling (TEC have been used to decorate cyclopeptides regioselectively with diverse combination of sugars. We demonstrate that the reaction sequence starting with TCC can be performed one-pot whereas the reverse sequence requires a purification step after the TEC reaction. The versatility of this orthogonal strategy has been demonstrated through the synthesis of diverse hGCs displaying alternating binary combinations of α-D-Man or β-D-GlcNAc, thus providing rapid access to attractive heteroglycosylated platforms for diverse biological applications.

  11. Photoinduced Thiol-ene Chemistry Applied to the Synthesis of Self-Assembling Elastin-Inspired Glycopeptides.

    Science.gov (United States)

    Piccirillo, Germano; Pepe, Antonietta; Bedini, Emiliano; Bochicchio, Brigida

    2017-02-21

    Synthetic (glyco)peptides inspired by proteins able to self-assemble are appealing biomaterials in the field of tissue engineering and regenerative medicine. Herein, for the first time, taking advantage of thiol-ene chemistry coupled to solid-phase peptide synthesis, a self-assembling peptide inspired by elastin protein was bioconjugated to three carbohydrates in order to obtain the corresponding glycopeptides. They were studied at the molecular and supramolecular level. The results show that the carbohydrate influences the molecular conformation of the glycopeptide and its self-aggregation properties as well. As future perspective, the results could enable us to tune the final self-aggregation properties of the glycopeptide by changing the sugar moiety. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Stereochemistry of 16a-Hydroxyfriedelin and 3-Oxo-16-methylfriedel-16-ene Established by 2D NMR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Vagner Fernandes Knupp

    2009-02-01

    Full Text Available Friedelin (1, 3b-friedelinol (2, 28-hydroxyfriedelin (3, 16a-hydroxyfriedelin (4, 30-hydroxyfriedelin (5 and 16a,28-dihydroxyfriedelin (6 were isolated through fractionation of the hexane extract obtained from branches of Salacia elliptica. After a week in CDCl3 solution, 16a-hydroxyfriedelin (4 reacted turning into 3-oxo-16-methylfriedel-16-ene (7. This is the first report of a dehydration followed by a Nametkin rearrangement of a pentacyclic triterpene in CDCl3 solution occurring in the NMR tube. These seven pentacyclic triterpenes was identified through NMR spectroscopy and the stereochemistry of compound 4 and 7 was established by 2D NMR (NOESY spectroscopy and mass spectrometry (GC-MS. It is also the first time that all the 13C-NMR and 2D NMR spectral data are reported for compounds 4 and 7.

  13. Molecular dynamics studies of the thermal decomposition of 2,3-diazabicyclo(2.2.1)hept-2-ene

    Science.gov (United States)

    Sorescu, Dan C.; Thompson, Donald L.; Raff, Lionel M.

    1995-05-01

    The reaction dynamics of the thermal gas-phase decomposition of 2,3-diazabicyclo (2.2.1)hept-2-ene-exo, exo-5,6-d2 have been investigated using classical trajectory methods on a semiempirical potential-energy surface. The global potential is written as a superposition of different reaction channel potentials containing bond stretching, bending and torsional terms, connected by parametrized switching functions. Reaction channels for stepwise and concerted cleavage of the two C-N bonds of the reactant have both been considered in construction of the potential. The geometries of 2,3-diazabicyclo(2.2.1)hept-2-ene, the diazenyl biradical and of the transition state corresponding to breaking of the remaining C-N bond of diazenyl biradical have been determined at the second order Möller-Plesset perturbation theory (MP2/6-31G*) and at Hartree-Fock (HF/6-31G*) levels, respectively. The bond dissociation energies have been estimated using the available thermochemical data and previously reported results for bicyclo(2.1.0)pentane [J. Chem. Phys. 101, 3729 (1994)]. The equilibrium geometries predicted by the semiempirical potential for reactants and products, the barrier height for thermal nitrogen extrusion from 2,3-diazabicyclo(2.2.1)hept-2-ene and the fundamental vibrational frequencies are in good to excellent agreement with the measured or ab initio calculated values. Using a projection method of the instantaneous Cartesian velocities onto the normal mode vectors and classical trajectory calculations, the dissociation dynamics of 2,3-diazabicyclo(2.2.1)hept-2-ene-exo, exo-5,6-d2 are investigated at several excitation energies in the range 60-175 kcal/mol. The results show the following: (1) The thermal reaction takes place with a preference for inversion of configuration in the reaction products, the exo-labeled bicyclo(2.1.0) pentane being the major product. The exo/endo ratio of bicyclo(2.1.0) pentane isomers is found to vary between 1.8-2.2 for the energy range

  14. Unexpected Carbon-Carbon Coupling between Organic Cyanides and an Isopropyl β-Carbon in a Hafnium Ene Diamide Complex

    OpenAIRE

    Bol, Johan E.; Hessen, Bart; Teuben, Jan H.; Smeets, Wilberth J.J.; Anthony L. Spek

    1992-01-01

    A reaction sequence involving two hydrogen transfers and a C-C coupling on the β-carbon of an isopropyl group leads to formation of a new dianionic tridentate ligand in the reaction of the ene diamide complex Cp*Hf(σ2,π-iPr-DAB)Cl (1; Cp* = η5-C5Me5, iPr-DAB = 1,4-diisopropyl-1,4-diaza-1,3-butadiene) with organic cyanides. The product Cp*Hf [iPrNCH=CHNC(Me)=CHC(tBu)=NH]Cl was structurally characterized (Pbca, a = 13.454 (1) Å, b = 11.470 (1) Å, c = 31.297 (2) Å, 100 K). The reaction sequence ...

  15. Facile preparation of organic-silica hybrid monolith for capillary hydrophilic liquid chromatography based on "thiol-ene" click chemistry.

    Science.gov (United States)

    Chen, Ming-Luan; Zhang, Jun; Zhang, Zheng; Yuan, Bi-Feng; Yu, Qiong-Wei; Feng, Yu-Qi

    2013-04-05

    In this work, a one-step approach to facile preparation of organic-inorganic hybrid monoliths was successfully developed. After vinyl-end organic monomers and azobisisobutyronitrile (AIBN) were mixed with hydrolyzed tetramethoxysilane (TMOS) and 3-mercaptopropyltrimethoxysilane (MPTMS), the homogeneous mixture was introduced into a fused-silica capillary for simultaneous polycondensation and "thiol-ene" click reaction to form the organic-silica hybrid monoliths. By employing this strategy, two types of organic-silica hybrid monoliths with positively charged quaternary ammonium and amide groups were prepared, respectively. The functional groups were successfully introduced onto the monoliths during the sol-gel process with "thiol-ene" click reaction, which was demonstrated by ζ-potential assessment, energy dispersive X-ray spectroscopy (EDX), and Fourier transform infrared (FT-IR) spectroscopy. The porous structure of the prepared monolithic columns was examined by scanning electron microscopy (SEM), nitrogen adsorption-desorption measurement, and mercury intrusion porosimetry. These results indicate the prepared organic-silica hybrid monoliths possess homogeneous column bed, large specific surface area, good mechanical stability, and excellent permeability. The prepared monolithic columns were then applied for anion-exchange/hydrophilic interaction liquid chromatography. Different types of analytes, including benzoic acids, inorganic ions, nucleosides, and nucleotides, were well separated with high column efficiency around 80,000-130,000 plates/m. Taken together, we present a facile and universal strategy to prepare organic-silica hybrid monoliths with a variety of organic monomers using one-step approach. Copyright © 2013 Elsevier B.V. All rights reserved.

  16. Assessment of 1-chloro-4-[2,2-dichloro-1-(4-chlorophenyl)ethenyl]benzene (DDE) Transformation Rates on the Palos Verdes Shelf, CA

    Science.gov (United States)

    Eganhouse, Robert P.; Pontolillo, James

    2008-01-01

    In 1953, the world's largest producer of DDT, Montrose Chemical Corporation, began to discharge process wastes into sewers of the Los Angeles County Sanitation Districts (LACSD), California. By 1971, when the sewer connection was terminated, approximately 1,500-2,000 metric tons of DDT had been introduced to the LACSD treatment plant in Carson, CA. After treatment, effluent from this plant was released to the ocean through a submarine outfall system on the Palos Verdes Shelf (PVS) near Los Angeles, resulting in the accumulation of highly contaminated marine sediments. Numerous investigations of the PVS have been undertaken since the late 1960s, but few have focused on the biogeochemical fate of DDT and its transformation products. In the early 1990s, it was shown that DDE, the major DDT compound in the sediments, was being reductively dechlorinated by microorganisms resident in sediments on the PVS. The U.S. Geological Survey undertook a study in cooperation with the U.S. Environmental Protection Agency to provide a better understanding of the range of reductive dechlorination rates on the PVS and the environmental factors that control them. Existing data show that rates of reductive dechlorination are variable spatially. A comparison of data from two cores collected approximately 7 kilometers downcurrent from the outfall systems in 1992 and 2003 yielded an average first-order transformation rate of approximately 0.05 yr-1. A multistep reaction model suggests that inventories of DDE in PVS sediments at the study site will continue to decline, whereas the inventory of the metabolite DDNU will reach a maximum around 2014.

  17. The Palos Verdes Fault offshore Southern California: Late Pleistocene to present tectonic geomorphology, seascape evolution, and slip rate estimate based on AUV and ROV surveys

    Science.gov (United States)

    Brothers, Daniel S.; Conrad, James E.; Maier, Katherine L.; Paull, Charles K.; McGann, Mary; Caress, David W.

    2015-07-01

    The Palos Verdes Fault (PVF) is one of few active faults in Southern California that crosses the shoreline and can be studied using both terrestrial and subaqueous methodologies. To characterize the near-seafloor fault morphology, tectonic influences on continental slope sedimentary processes and late Pleistocene to present slip rate, a grid of high-resolution multibeam bathymetric data, and chirp subbottom profiles were acquired with an autonomous underwater vehicle (AUV) along the main trace of PVF in water depths between 250 and 600 m. Radiocarbon dates were obtained from vibracores collected using a remotely operated vehicle (ROV) and ship-based gravity cores. The PVF is expressed as a well-defined seafloor lineation marked by subtle along-strike bends. Right-stepping transtensional bends exert first-order control on sediment flow dynamics and the spatial distribution of Holocene depocenters; deformed strata within a small pull-apart basin record punctuated growth faulting associated with at least three Holocene surface ruptures. An upper (shallower) landslide scarp, a buried sedimentary mound, and a deeper scarp have been right-laterally offset across the PVF by 55 ± 5, 52 ± 4 , and 39 ± 8 m, respectively. The ages of the upper scarp and buried mound are approximately 31 ka; the age of the deeper scarp is bracketed to 17-24 ka. These three piercing points bracket the late Pleistocene to present slip rate to 1.3-2.8 mm/yr and provide a best estimate of 1.6-1.9 mm/yr. The deformation observed along the PVF is characteristic of strike-slip faulting and accounts for 20-30% of the total right-lateral slip budget accommodated offshore Southern California.

  18. The Palos Verdes Fault offshore southern California: late Pleistocene to present tectonic geomorphology, seascape evolution and slip rate estimate based on AUV and ROV surveys

    Science.gov (United States)

    Brothers, Daniel S.; Conrad, James E.; Maier, Katherine L.; Paull, Charles K.; McGann, Mary L.; Caress, David W.

    2015-01-01

    The Palos Verdes Fault (PVF) is one of few active faults in Southern California that crosses the shoreline and can be studied using both terrestrial and subaqueous methodologies. To characterize the near-seafloor fault morphology, tectonic influences on continental slope sedimentary processes and late Pleistocene to present slip rate, a grid of high-resolution multibeam bathymetric data, and chirp subbottom profiles were acquired with an autonomous underwater vehicle (AUV) along the main trace of PVF in water depths between 250 and 600 m. Radiocarbon dates were obtained from vibracores collected using a remotely operated vehicle (ROV) and ship-based gravity cores. The PVF is expressed as a well-defined seafloor lineation marked by subtle along-strike bends. Right-stepping transtensional bends exert first-order control on sediment flow dynamics and the spatial distribution of Holocene depocenters; deformed strata within a small pull-apart basin record punctuated growth faulting associated with at least three Holocene surface ruptures. An upper (shallower) landslide scarp, a buried sedimentary mound, and a deeper scarp have been right-laterally offset across the PVF by 55 ± 5, 52 ± 4 , and 39 ± 8 m, respectively. The ages of the upper scarp and buried mound are approximately 31 ka; the age of the deeper scarp is bracketed to 17–24 ka. These three piercing points bracket the late Pleistocene to present slip rate to 1.3–2.8 mm/yr and provide a best estimate of 1.6–1.9 mm/yr. The deformation observed along the PVF is characteristic of strike-slip faulting and accounts for 20–30% of the total right-lateral slip budget accommodated offshore Southern California.

  19. Utilizing Tritium and CFC-12 to Determine Groundwater Sources in an Unconfined Aquifer Within the Abalone Cove Landslide, Palos Verdes, California

    Science.gov (United States)

    Difilippo, E. L.; Hammond, D. E.; Douglas, R.; Clark, J. F.; Avisar, D.; Dunker, R.

    2004-12-01

    The Abalone Cove landslide occupies 80 acres of an ancient landslide complex on the Palos Verdes peninsula, and was re-activated in 1979. The uphill portion of the ancient landslide complex has remained stable in historic times. Water infiltration into the slide is a short term catalyst for mass movement in the area, so it is important to determine the sources of groundwater throughout the slide mass. Water may enter the slide mass through direct percolation of recent precipitation, inflow along the head scarp of the ancient landslide or by rising through the slide plane from a deeper aquifer. The objective of this contribution is to use geochemical tracers (tritium and CFC-12) in combination with numerical modeling to constrain the importance of each of these sources. Numerical models were constructed to predict geochemical tracer concentrations throughout the basin, assuming that the only source of water to the slide mass is percolation of recent precipitation. Predicted concentrations were then compared to measured tracer values. In the ancient landslide, predicted and measured tracer concentrations are in good agreement, indicating that most of the water in this area is recent precipitation falling within the basin. Groundwater recharged uphill of the ancient landslide contributes minor flow into the complex through the head scarp, with the majority of this water flowing beneath the ancient slide plane. However, predicted tracer concentrations in the toe of the Abalone Cove landslide are not consistent with measured values. Both CFC-12 and tritium concentrations indicate that water is older than predicted and communication between the slide mass and the aquifer beneath the slide plane must occur in this area. Infiltration of this deep circulating water may exert upward hydraulic pressure on the landslide slip surface, increasing the potential for movement. This hypothesis is consistent with the observation that current movement is only occurring in the area in

  20. The IS-ENES climate4impact portal: bridging the CMIP5 and CORDEX data to impact users

    Science.gov (United States)

    Som de Cerff, Wim; Plieger, Maarten; Page, Christian; Tatarinova, Natalia; Hutjes, Ronald; de Jong, Fokke; Bärring, Lars; Sjökvist, Elin; Vega Saldarriaga, Manuel; Santiago Cofiño Gonzalez, Antonio

    2015-04-01

    The aim of climate4impact (climate4impact.eu) is to enhance the use of Climate Research Data and to enhance the interaction with climate effect/impact communities. The portal is based on 17 impact use cases from 5 different European countries, and is evaluated by a user panel consisting of use case owners. It has been developed within the IS-ENES European project and is currently operated and further developed in the IS ENES2 project. As the climate impact community is very broad, the focus is mainly on the scientific impact community. Climate4impact is connected to the Earth System Grid Federation (ESGF) nodes containing global climate model data (GCM data) from the fifth phase of the Coupled Model Intercomparison Project (CMIP5) and regional climate model data (RCM) data from the Coordinated Regional Climate Downscaling Experiment (CORDEX). This global network of climate model data centers offers services for data description, discovery and download. The climate4impact portal connects to these services using OpenID, and offers a user interface for searching, visualizing and downloading global climate model data and more. A challenging task is to describe the available model data and how it can be used. The portal informs users about possible caveats when using climate model data. All impact use cases are described in the documentation section, using highlighted keywords pointing to detailed information in the glossary. Climate4impact currently has two main objectives. The first one is to work on a web interface which automatically generates a graphical user interface on WPS endpoints. The WPS calculates climate indices and subset data using OpenClimateGIS/icclim on data stored in ESGF data nodes. Data is then transmitted from ESGF nodes over secured OpenDAP and becomes available in a new, per user, secured OpenDAP server. The results can then be visualized again using ADAGUC WMS. Dedicated wizards for processing of climate indices will be developed in close

  1. First example of stepwise, zwitterionic mechanism for bicyclo[2.2.1]hept-5-ene (norbornene) formation process catalyzed by the 1-butyl-3-methylimidazolium cations.

    Science.gov (United States)

    Jasiński, Radomir

    B3LYP/6-31++G(d) calculations indicated that the reaction of (2 E )-3-phenyl-2-nitroprop-2-enenitrile with cyclopentadiene catalyzed by cations of 1,3-dialkylimidazolium ionic liquid shall not take place according to the classical scheme of one-step [2+4] Diels-Alder cycloaddition. Along the path finally leading to bicyclo[2.2.1]hept-5-ene (norbornene) with a nitro group in endo orientation, the process of bicarbocyclic skeleton formation shall take place according to the domino mechanism, via [2+4] heterocycloadduct. On the other hand, along the path leading finally to bicyclo[2.2.1]hept-5-ene with a nitro group in exo orientation, acyclic adduct with a zwitterionic nature is formed in the first reaction, which undergoes cyclisation next in the second step of the reaction.

  2. Polysiloxane-Based Autonomic Self-Healing Elastomers Obtained through Dynamic Boronic Ester Bonds Prepared by Thiol-Ene "Click" Chemistry.

    Science.gov (United States)

    Zuo, Yujing; Gou, Zhiming; Zhang, Changqiao; Feng, Shengyu

    2016-07-01

    Cross-linked silicone elastomers constructed with dynamic-covalent boronic esters are first synthesized by photoinitiated radical thiol-ene "click" chemistry. The resultant samples can be cut with a sharp knife into two pieces and then healed via the reversibility of the boronic ester cross-linkages to restore the original silicone sample within 30 min. Regulation of luminescent properties is achieved by incorporating organic dye into the elastomers through a "one-pot" thiol-ene reaction. The proposed synthesis procedure demonstrates a new strategy to produce boronic acid silicone materials capable of self-healing without external forces. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. [3,3]-Sigmatropic shifts and retro-ene rearrangements in cyanates, isocyanates, thiocyanates, and isothiocyanates of the form RX-YCN and RX-NCY.

    Science.gov (United States)

    Koch, Rainer; Finnerty, Justin J; Murali, Sukumaran; Wentrup, Curt

    2012-02-17

    Retro-ene type [2π + 2π + 2σ] and [3,3]-sigmatropic shift reactions involving the substituent groups R in heteroatom-substituted cyanates and thiocyanates RX-YCN and the isomeric isocyanates and isothiocyanates of the type RX-NCY (X = CR(2), NR', O, or S; Y = O or S) have been investigated computationally at the B3LYP/6-311++G(d,p) level. Retro-ene reactions of alkyl derivatives of the title compounds afford alkenes, imines, carbonyl and thiocarbonyl compounds together with HNCO (HNCS) or HOCN (HSCN). [3,3]-Sigmatropic shifts (hetero-Cope rearrangements) of the corresponding allyl, propargyl, benzyl, and aryl derivatives causes allylic rearrangements, propargyl-allenyl rearrangement, conversion of benzyl cyanates to o-isocyanatotoluenes, and conversion of N-cyanatoarylamines to o-isocyanatoanilines, etc. The corresponding rearrangements of allyl thiocyanates, arylamino thiocyanates and isothiocyanates, and arylsulfenyl thiocyanates and isothiocyanates are also described.

  4. Thiol-ene thermosets exploiting surface reactivity for layer-by-layer structures and control of penetration depth for selective surface reactivity

    DEFF Research Database (Denmark)

    Daugaard, Anders Egede; Westh, Andreas; Pereira Rosinha Grundtvig, Ines

    Thiol-ene thermosets have been shown to be an efficient platform for preparation of functional polymer surfaces. Especially the effectiveness and versatility of the system has enabled a large variety of network properties to be obtained in a simple and straight-forward way. Due to its selectivity......, various thiols and allyl or other vinyl reactants can be used to obtain either soft and flexible1 or more rigid functional thermosets 2. The methodology permits use of etiher thermal or photochemical conditions both for matrix preparation as well as for surface functionalization. Due to excess reactive...... groups in thµe surface of thiol-ene thermosets, it is possible to prepare surface functional thermosets or to exploit the reactive groups for modular construction and subsequent chemical bonding. Here a different approach preparing monolithic layer-by-layer structures with controlled mechanical...

  5. Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles.

    Science.gov (United States)

    Yan, Yue; Fu, Jie; Wang, Tianfu; Lu, Xiuyang

    2017-03-15

    As efficient drug carriers, stimuli-responsive mesoporous silica nanoparticles are at the forefront of research on drug delivery systems. An acid-responsive system based on silyl ether has been applied to deliver a hybrid prodrug. Thiol-ene click chemistry has been successfully utilized for tethering this prodrug to mesoporous silica nanoparticles. Here, by altering the steric bulk of the substituent on the silicon atom, the release rate of a model drug, camptothecin, was controlled. The synthesized drug delivery system was investigated by analytical methods to confirm the functionalization and conjugation of the mesoporous silica nanoparticles. Herein, trimethyl silyl ether and triethyl silyl ether were selected to regulate the release rate. Under normal plasma conditions (pH 7.4), both types of camptothecin-loaded mesoporous silica nanoparticles (i.e., MSN-Me-CPT and MSN-Et-CPT) did not release the model drug. However, under in vitro acidic conditions (pH 4.0), based on a comparison of the release rates, camptothecin was released from MSN-Me-CPT more rapidly than from MSN-Et-CPT. To determine the biocompatibility of the modified mesoporous silica nanoparticles and the in vivo camptothecin uptake behavior, MTT assays with cancer cells and confocal microscopy observations were conducted, with positive results. These functionalized nanoparticles could be useful in clinical treatments requiring controlled drug release. As the release rate of drug from drug-carrier plays important role in therapy effects, trimethyl silyl ether (TMS) and triethyl silyl ether (TES) were selected as acid-sensitive silanes to control the release rates of model drugs conjugated from MSNs by thiol-ene click chemistry. The kinetic profiles of TMS and TES materials have been studied. At pH 4.0, the release of camptothecin from MSN-Et-CPT occurred after 2h, whereas MSN-Me-CPT showed immediate drug release. The results showed that silyl ether could be used to control release rates of drugs from

  6. Vapor-liquid interfacial reaction to fabricate superhydrophilic and underwater superoleophobic thiol-ene/silica hybrid decorated fabric for oil/water separation

    Science.gov (United States)

    Li, Hongqiang; Liang, Tao; Lai, Xuejun; Su, Xiaojing; Zhang, Lin; Zeng, Xingrong

    2018-01-01

    With oil spill accidents and oil industrial wastewater increasing, oil/water separation has attracted much attention in recent years. Herein, we report the fabrication of superhydrophilic and underwater superoleophobic thiol-ene/silica hybrid decorated fabrics for oil/water separation via vapor-liquid interfacial reaction. It is based on sol-gel reaction of tetraethyl orthosilicate (TEOS) to generate silica and thiol-ene reaction between poly(ethylene glycol) dimethacrylate (PEGDMA) and trimethylolpropane tris(3-mercaptopropionate) (TTMP) to form crosslinked hydrophilic polymer on polyester fabric under the catalysis of butylamine/ammonia vapor. The chemical structure of the surfaces on thiol-ene/silica hybrid decorated fabric was confirmed by FTIR and XPS, and obvious micro-nano morphology and roughness were observed with SEM and AFM. The water contact angle of the fabric attained 0° in 0.36 s, and the underwater oil contact angle reached up to 160°. Importantly, the fabric exhibited high separation efficiency at 99.5%, fast water flux above 71600 Lm-2h-1 and excellent recyclability in oil/water separation. Our findings open a new strategy to fabricate organic-inorganic hybrid superhydrophobic and underwater superoleophobic materials for oil/water separation.

  7. Enantioselective Reduction of Citral Isomers in NCR Ene Reductase: Analysis of an Active-Site Mutant Library.

    Science.gov (United States)

    Kress, Nico; Rapp, Johanna; Hauer, Bernhard

    2017-04-18

    A deeper understanding of the >99 % S-selective reduction of both isomers of citral catalyzed by NCR ene reductase was achieved by active-site mutational studies and docking simulation. Though structurally similar, the E/Z isomers of citral showed a significantly varying selectivity response to introduced mutations. Although it was possible to invert (E)-citral reduction enantioselectivity to ee 46 % (R) by introducing mutation W66A, for (Z)-citral it remained ≥88 % (S) for all single-residue variants. Residue 66 seems to act as a lever for opposite binding modes. This was underlined by a W66A-based double-mutant library that enhanced the (E)-citral derived enantioselectivity to 63 % (R) and significantly lowered the S selectivity for (Z)-citral to 44 % (S). Formation of (R)-citronellal from an (E/Z)-citral mixture is a desire in industrial (-)-menthol synthesis. Our findings pave the way for a rational enzyme engineering solution. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Synthesis and Antimicrobial Activity of N-(6-Carboxyl Cyclohex-3-ene Carbonyl Chitosan with Different Degrees of Substitution

    Directory of Open Access Journals (Sweden)

    Mohamed E. I. Badawy

    2016-01-01

    Full Text Available Five products of N-(6-carboxyl cyclohex-3-ene carbonyl chitosan as antimicrobial agents were prepared by reaction of chitosan with tetrahydrophthalic anhydride (THPA at different degrees of substitution (DS. The antimicrobial activity was evaluated against four plant bacteria and eight fungi. The results proved that the inhibitory property and water solubility of the synthesized chitosan derivatives, with increase of the DS, exhibited a remarkable improvement over chitosan. The product with a DS of 0.40 was the most active one with MIC of 510, 735, 240, and 385 mg/L against Erwinia carotovora, Ralstonia solanacearum, Rhodococcus fascians, and Rhizobium radiobacter, respectively, and also in mycelial growth inhibition against Alternaria alternata (EC50 = 683 mg/L, Botrytis cinerea (EC50 = 774 mg/L, Botryodiplodia theobromae (EC50 = 501 mg/L, Fusarium oxysporum (EC50 = 500 mg/L, F. solani (EC50 = 260 mg/L, Penicillium digitatum (EC50 = 417 mg/L, Phytophthora infestans (EC50 = 298 mg/L, and Sclerotinia sclerotiorum (EC50 = 763 mg/L. These compounds based on a biodegradable and biocompatible chitosan could be used as potentially antimicrobial agents in crop protection instead of hazardous synthetic pesticides.

  9. Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription.

    Science.gov (United States)

    Osorio, Alex A; Muñóz, Alejandro; Torres-Romero, David; Bedoya, Luis M; Perestelo, Nayra R; Jiménez, Ignacio A; Alcamí, José; Bazzocchi, Isabel L

    2012-06-01

    In the present study we report the isolation of nine new olean-18-ene triterpenes (1-9), along with three known ones (10-12), from Cassine xylocarpa and Maytenus jelskii. Their stereostructures have been elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR techniques (COSY, ROESY, HSQC and HMBC), and spectrometric methods. The natural compounds and derivatives 13-15 have been tested for their potential as inhibitors of human immunodeficiency virus type 1 replication. Five compounds from this series displayed potent antiviral activity with IC(50)s in the micromolar range (1, 3, 4, 7 and 8) being 1 and 8 the most active compounds. The target of these compounds was different from antiretroviral drugs currently licensed as they act as inhibitors of enhancer-dependent transcription. The structure-activity relationships were established based on the regiosubstitution and oxidation degree of the triterpene scaffold, revealing that these aspects were able to modulate the selectivity and intensity of HIV inhibition. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  10. Low-Cost Perovskite Solar Cells Employing Dimethoxydiphenylamine-Substituted Bistricyclic Aromatic Enes as Hole Transport Materials.

    Science.gov (United States)

    Rakstys, Kasparas; Paek, Sanghyun; Grancini, Giulia; Gao, Peng; Jankauskas, Vygintas; Asiri, Abdullah M; Nazeeruddin, Mohammad Khaja

    2017-10-09

    The synthesis, characterization and photovoltaic performance of series of novel molecular hole transport materials (HTMs) based on bistricyclic aromatic enes (BAEs) are presented. The new derivatives were obtained following a simple and straightforward procedure from inexpensive starting reagents mimicking the synthetically challenging 9,9'-spirobifluorene moiety of the well-studied spiro-OMeTAD. The novel HTMs were tested in mixed cations and anions perovskite solar cells (PSCs) yielding a power conversion efficiency (PCE) of 19.2 % under standard global 100 mW cm-2 AM1.5G illumination using 9-{2,7-bis[bis(4-methoxyphenyl)amino]-9H-fluoren-9-ylidene}-N2 ,N2 ,N7 ,N7 -tetrakis(4-methoxyphenyl)-9H-thioxanthene-2,7-diamine (coded as KR374). The power conversion efficiency data confirms the easily attainable heteromerous fluorenylidenethioxanthene structure as valuable core for low-cost and highly efficient HTM design and paves the way towards cost-effective PSC technology. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Thiol-Ene Photo-Click Collagen-PEG Hydrogels: Impact of Water-Soluble Photoinitiators on Cell Viability, Gelation Kinetics and Rheological Properties

    Directory of Open Access Journals (Sweden)

    Róisín Holmes

    2017-06-01

    Full Text Available Thiol-ene photo-click hydrogels were prepared via step-growth polymerisation using thiol-functionalised type-I collagen and 8-arm poly(ethylene glycol norbornene-terminated (PEG-NB, as a potential injectable regenerative device. Type-I collagen was thiol-functionalised by a ring opening reaction with 2-iminothiolane (2IT, whereby up to 80 Abs.% functionalisation and 90 RPN% triple helical preservation were recorded via 2,4,6-Trinitrobenzenesulfonic acid (TNBS colorimetric assay and circular dichroism (CD. Type, i.e., either 2-Hydroxy-1-[4-(2-hydroxyethoxy phenyl]-2-methyl-1-propanone (I2959 or lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP, and concentration of photoinitiator were varied to ensure minimal photoinitiator-induced cytotoxicity and to enable thiol-ene network formation of collagen-PEG mixtures. The viability of G292 cells following 24 h culture in photoinitiator-supplemented media was largely affected by the photoinitiator concentration, with I2959-supplemented media observed to induce higher toxic response (0.1 → 0.5% (w/v I2959, cell survival: 62 → 2 Abs.% compared to LAP-supplemented media (cell survival: 86 → 8 Abs.%. In line with the in vitro study, selected photoinitiator concentrations were used to prepare thiol-ene photo-click hydrogels. Gelation kinetics proved to be largely affected by the specific photoinitiator, with LAP-containing thiol-ene mixtures leading to significantly reduced complete gelation time (τ: 187 s with respect to I2959-containing mixtures (τ: 1683 s. Other than the specific photoinitiator, the photoinitiator concentration was key to adjusting the hydrogel storage modulus (G’, whereby 15-fold G’ increase (232 → 3360 Pa was observed in samples prepared with 0.5% (w/v compared to 0.1% (w/v LAP. Further thiol-ene formulations with 0.5% (w/v LAP and varied content of PEG-NB were tested to prepare photo-click hydrogels with porous architecture, as well as tunable storage modulus (G

  12. Trophic transfer and effects of DDT in male hornyhead turbot (Pleuronichthys verticalis) from Palos Verdes Superfund site, CA (USA) and comparisons to field monitoring.

    Science.gov (United States)

    Crago, Jordan; Xu, Elvis Genbo; Kupsco, Allison; Jia, Fang; Mehinto, Alvine C; Lao, Wenjian; Maruya, Keith A; Gan, Jay; Schlenk, Daniel

    2016-06-01

    High concentrations of DDT and metabolites (ΣDDT) have been detected in sediment and the demersal flatfish hornyhead turbot (Pleuronichtys verticalis) collected from Palos Verdes (PV), California, USA, a site contaminated with over 100 metric tons of DDT throughout 1960s-70s. This study was conducted to assess the transfer of ΣDDT from PV-sediment into polychaetes (Neanthes arenaceodentata) and hornyhead turbot, and to investigate if the responses in turbots from two different laboratory exposures mimic those in turbots caught in PV (PV-turbot). Turbot fed PV-sediment-contaminated polychaete for 7 days had liver concentrations of ΣDDT similar to PV-turbot. After 28 days, ΣDDT also accumulated in livers of turbot gavaged with a ΣDDT mixture. In vitro cell bioassays indicated significant increases of 17β-estradiol equivalents (EEQ) in turbot bile extracts as compared to the control in the 7-day study. These responses corresponded to those measured in PV-fish. Glucocorticoid receptor (GR), anti-androgen receptor (anti-AR), estrogen receptor (ER) or aryl hydrocarbon receptor (AhR) activities were also observed in extracts of PV-sediment, and PV-sediment-exposed worm. Anti-AR, AhR and GR activities were significantly higher in PV-sediment than reference sediment (San Diego, SD). Higher transcripts of hepatic VTG, ERα and ERβ were found in PV-turbot than SD-turbot, but were unaltered in fish exposed to sediment-contaminated worms for the 7-day study. In contrast, liver extracts from the 28-day treatment of ΣDDT showed lower EEQ but similar hepatic VTG and ERβ transcripts relative to those of PV-turbot. These data indicated that trophic transfer of sediment-associated DDT in 7-day exposures corresponded to field measurements of DDT residues and in vitro ER bioactivities, but failed to mimic in vivo biological effects observed in field fish. In contrast, treatment with ΣDDT alone for 28 days mimicked in vivo biological effects of DDTs in PV fish, but did not

  13. Possible Connections Between the Coronado Bank Fault Zone and the Newport-Inglewood, Rose Canyon, and Palos Verdes Fault Zones Offshore San Diego County, California.

    Science.gov (United States)

    Sliter, R. W.; Ryan, H. F.

    2003-12-01

    High-resolution multichannel seismic-reflection and deep-tow Huntec data collected by the USGS were interpreted to map the Coronado Bank fault zone (CBFZ) offshore San Diego County, California. The CBFZ is comprised of several major strands (eastern, central, western) that change in both orientation and degree of deformation along strike. Between Coronado Bank and San Diego, the CBFZ trends N25W and occupies a narrow 7 km zone. Immediately north of La Jolla submarine canyon (LJSC), the easternmost strand changes orientation to almost due north and appears to be offset in a right-lateral sense across the canyon axis. The strand merges with a prominent fault that follows the base of the continental slope in about 600 m water depth. The central portion of the CBFZ is mapped as a negative flower structure and deforms seafloor sediment as far north as 15 km north of LJSC. Farther north, this structure is buried by more than 400 m of basin sediment. Along the eastern edge of the Coronado Bank, the western portion of the CBFZ is characterized by high angle normal faults that dip to the east. North of the Coronado Bank, the western segment follows the western edge of a basement high; it cuts through horizontal basin reflectors and in places deforms the seafloor. We mapped an additional splay of the CBFZ that trends N40W; it is only observed north and west of LJSC. Although the predominant trend of the CBFZ is about N40W, along strike deviations from this orientation of some of the strands indicate that these strands connect with other offshore fault zones in the area. Based on the limited data available, the trend of the CBFZ south of Coronado Bank suggests that it might connect with the Rose Canyon fault zone (RCFZ) that has been mapped in San Diego Bay. North of Coronado Bank, the CBFZ is a much broader fault zone (about 25 km wide) composed of diverging fault strands. The westernmost strand may merge with the western strand of the Palos Verdes fault zone (PVFZ) south of

  14. Potential depletion of surface water in the Colorado River and agricultural drains by groundwater pumping in the Parker-Palo Verde-Cibola area, Arizona and California

    Science.gov (United States)

    Leake, Stanley A.; Owen-Joyce, Sandra J.; Heilman, Julian A.

    2013-01-01

    Water use along the lower Colorado River is allocated as “consumptive use,” which is defined to be the amount of water diverted from the river minus the amount that returns to the river. Diversions of water from the river include surface water in canals and water removed from the river by pumping wells in the aquifer connected to the river. A complication in accounting for water pumped by wells occurs if the pumping depletes water in drains and reduces measured return flow in those drains. In that case, consumptive use of water pumped by the wells is accounted for in the reduction of measured return flow. A method is needed to understand where groundwater pumping will deplete water in the river and where it will deplete water in drains. To provide a basis for future accounting for pumped groundwater in the Parker-Palo Verde-Cibola area, a superposition model was constructed. The model consists of three layers of finite-difference cells that cover most of the aquifer in the study area. The model was run repeatedly with each run having a pumping well in a different model cell. The source of pumped water that is depletion of the river, expressed as a fraction of the pumping rate, was computed for all active cells in model layer 1, and maps were constructed to understand where groundwater pumping depletes the river and where it depletes drains. The model results indicate that if one or more drains exist between a pumping well location and the river, nearly all of the depletion will be from drains, and little or no depletion will come from the Colorado River. Results also show that if a well pumps on a side of the river with no drains in the immediate area, depletion will come from the Colorado River. Finally, if a well pumps between the river and drains that parallel the river, a fraction of the pumping will come from the river and the rest will come from the drains. Model results presented in this report may be considered in development or refinement of strategies

  15. Urve Palo : Utshitsja nuzhno vsem / Urve Palo ; interv. Jevgenija Gorski

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2007-01-01

    Intervjuu rahvastikuminister Urve Paloga integratsiooniteemadel. Minister peab vajalikuks siinsetele inimestele teadvustada mõtet, et meil võivad olla erinevad kultuurid ja keel, kuid ühtne tulevik ja kodumaa

  16. Regulation of a putative corticosteroid, 17, 21-dihydroxypregn-4-ene, 3, 20-one, in sea lamprey, Petromyzon marinus.

    Science.gov (United States)

    Roberts, Brent W.; Didier, Wes; Satbir, Rai; Johnson, Nicholas S.; Libants, Scot V.; Sang-Seon, Yun; Close, David

    2013-01-01

    In higher vertebrates, in response to stress, the hypothalamus produces corticotropin-releasing hormone (CRH), which stimulates cells in the anterior pituitary to produce adrenocorticotropic hormone (ACTH), which in turn stimulates production of either cortisol (F) or corticosterone (B) by the adrenal tissues. In lampreys, however, neither of these steroids is present. Instead, it has been proposed that the stress steroid is actually 17,21-dihydroxypregn-4-ene-3,20-dione (11-deoxycortisol; S). However, there have been no studies yet to determine its mechanism of regulation or site of production. Here we demonstrate that (1) intraperitoneal injections of lamprey-CRH increase plasma S in a dose dependent manner, (2) intraperitoneal injections of four lamprey-specific ACTH peptides at 100 lg/kg, did not induce changes in plasma S concentrations in either males or females; (3) two lamprey-specific gonadotropin-releasing hormones (GnRH I and III) and arginine-vasotocin (AVT), all at single doses, stimulated S production as well as, or to an even greater extent than CRH; (4) sea lamprey mesonephric kidneys, in vitro, converted tritiated 17a-hydroxyprogesterone (17a-P) into a steroid that had the same chromatographic properties (on HPLC and TLC) as S; (5) kidney tissues released significantly more immunoassayable S into the incubation medium than gill, liver or gonad tissues. One interpretation of these results is that the corticosteroid production of the sea lamprey, one of the oldest extant vertebrates, is regulated through multiple pathways rather than the classical HPI-axis. However, the responsiveness of this steroid to the GnRH peptides means that a reproductive rather than a stress role for this steroid cannot yet be ruled out.

  17. A stepwise retro-imino-ene as a key step in the mechanism of allene formation via the Crabbé acetylene homologation.

    Science.gov (United States)

    González, Marta; Rodríguez, Roi Álvarez; Cid, Maria Magdalena; López, Carlos Silva

    2012-05-15

    The mechanism of the acetylene homologation procedure accidentally discovered and further developed by Crabbé and coworkers is unknown. Kinetic isotope effect (KIE) experiments, however, suggest that an intramolecular hydrogen shift is the key step of the transformation. In this work, we present a computational study of this mechanism. We found that the reaction proceeds via an unexpected stepwise retro-imino-ene rearrangement. This mechanism justifies the role of Cu(I) as a reaction catalyst and is also compatible with the KIE experiments reported. Copyright © 2012 Wiley Periodicals, Inc.

  18. Facile synthesis of linear-dendritic cholesteryl-poly(epsilon-caprolactone)-b-(L-lysine)(G2) by thiol-ene and azide-alkyne "click" reactions

    DEFF Research Database (Denmark)

    Javakhishvili, Irakli; Binder, W.H.; Tanner, S.

    2010-01-01

    The construction of a linear-dendritic block copolymer consisting of terminal cholesteryl moiety, poly(epsilon-caprolactone), and a second generation L-lysine dendron has been accomplished by the combination of copper(I) catalyzed azide-alkyne and UV-triggered thiol-ene "click" reactions. Ring......-opening polymerization of E-caprolactone initiated by 5-hexyn-1-ol and Mitsunobu coupling with 4-pentenoic acid provide hetero-telechelic poly(epsilon-caprolactone) bearing terminal alkyne and alkene groups. It is then employed in the sequential "click" reactions with the azide-functionalized dendritic wedge...

  19. Volumetric Properties of the Mixture Hex-1-ene C6H12 + C10H12 1,2,3,4-Tetrahydronaphthalene (VMSD1211, LB3980_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Hex-1-ene C6H12 + C10H12 1,2,3,4-Tetrahydronaphthalene (VMSD1211, LB3980_V)' providing data from direct low-pressure dilatometric measurement of molar excess volume at variable mole fraction and constant temperature.

  20. Heat of Mixing and Solution of Hex-1-ene C6H12 + C12H16 Cyclohexylbenzene (HMSD1111, LB4068_H)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Heat of Mixing and Solution of Hex-1-ene C6H12 + C12H16 Cyclohexylbenzene (HMSD1111, LB4068_H)' providing data from direct low-pressure calorimetric measurement of molar excess enthalpy at variable mole fraction and constant temperature.

  1. Vapor-Liquid Equilibrium in the Mixture 3-Methylthiophene C5H6S + C6H12 Hex-1-ene (EVLM1131, LB5703_E)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'vapor-liquid Equilibrium in the Mixture 3-Methylthiophene C5H6S + C6H12 Hex-1-ene (EVLM1131, LB5703_E)' providing data from direct measurement of pressure and mole fraction in vapor phase at variable mole fraction in liquid phase and constant temperature.

  2. Heat of Mixing and Solution of 2-Methylpyridine C6H7N + C6H12 Hex-1-ene (HMSD1111, LB3864_H)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Heat of Mixing and Solution of 2-Methylpyridine C6H7N + C6H12 Hex-1-ene (HMSD1111, LB3864_H)' providing data from direct low-pressure calorimetric measurement of molar excess enthalpy at variable mole fraction and constant temperature.

  3. Volumetric Properties of the Mixture Hex-1-ene C6H12 + C8H10 1,2-Dimethylbenzene (VMSD1212, LB4577_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Hex-1-ene C6H12 + C8H10 1,2-Dimethylbenzene (VMSD1212, LB4577_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  4. Volumetric Properties of the Mixture Hex-1-ene C6H12 + C8H10 1,2-Dimethylbenzene (VMSD1111, LB5004_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Hex-1-ene C6H12 + C8H10 1,2-Dimethylbenzene (VMSD1111, LB5004_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  5. Volumetric Properties of the Mixture Hex-1-ene C6H12 + C12H16 Cyclohexylbenzene (VMSD1211, LB3987_V)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Hex-1-ene C6H12 + C12H16 Cyclohexylbenzene (VMSD1211, LB3987_V)' providing data from direct low-pressure dilatometric measurement of molar excess volume at variable mole fraction and constant temperature.

  6. Heat of Mixing and Solution of Hex-1-ene C6H12 + C10H12 1,2,3,4-Tetrahydronaphthalene (HMSD1111, LB4061_H)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Heat of Mixing and Solution of Hex-1-ene C6H12 + C10H12 1,2,3,4-Tetrahydronaphthalene (HMSD1111, LB4061_H)' providing data from direct low-pressure calorimetric measurement of molar excess enthalpy at variable mole fraction and constant temperature.

  7. Syntheses of Four Enantiomers of 2,3-Diendo- and 3-Endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic Acid and Their Saturated Analogues

    Directory of Open Access Journals (Sweden)

    Márta Palkó

    2013-12-01

    Full Text Available Ethyl 2,3-diendo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylate ((±-1 was resolved with O,O'-dibenzoyltartaric acid via diastereomeric salt formation. The efficient synthesis of the enantiomers of 2,3-diendo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acid ((+-7 and (–-7, 3-endo-aminobicyclo[2.2.2]oct-5-ene-2-exo-carboxylic acid ((+-5 and (–-5, cis- and trans-3-aminobicyclo[2.2.2]octane-2-carboxylic acid ((+-6, (–-6, (+-8 and (–-8 was achieved via isomerization, hydrogenation and hydrolysis of the corresponding esters (–-1 and (+-1. The stereochemistry and relative configurations of the synthesized compounds were determined by NMR spectroscopy (based on the 3J(H,H coupling constants and X-ray crystallography.

  8. Porušena crkva Rođenja Blažene Djevice Marije u Silbi

    Directory of Open Access Journals (Sweden)

    Eugen Motušić

    2014-12-01

    Full Text Available Već otprije je bio poznat podatak da se godine 1828. u Silbi porušila stara crkva Rođenja B.D. Marije kako bi se dobivenim građevinskim materijalom dovršila prekinuta gradnja nove župne crkve koja naslijeđuje i njen titular. Prema arhivskim podacima rušenje je dozvolio zadarski nadbiskup Josip Nowak i odredio da se do izgradnje nove crkve kao župna koristi nekadašnja franjevačka Gospe od Karmela. Od čitavog je sklopa do danas sačuvan tek zvonik koji je ostao služiti novoj župnoj crkvi. Prema shematiziranim tlocrtu i dimenzijama porušene crkve, dokumentiranima u danas zagubljenom spisu iz župnog arhiva, razvidno je da se radilo o jednobrodnoj longitudinalnoj crkvi s pravokutnom, od lađe užom sakristijom na začelju, dvjema plitkim kapelama dograđenima uz pobočne zidove, te otvorenim predvorjem (ložom duž pročelja koje se svojim južnim uglom oslanjalo na ugao zvonika. Crkvena je dvorana osim glavnog oltara prislonjenog uz začelje lađe imala tri para pobočnih oltara. Analiza apostolskih i kanonskih vizitacija crkve, prvi puta spomenute 1579. godine, pokazuje da je još u drugoj četvrtini 17. stoljeća ona bila skromna građevina u kojoj se, radi udaljenosti tadašnje župne crkve sv. Marka od naselja, čuva ulje za bolesničko pomazanje. Ipak, crkva je tada imala pet pobočnih oltara koje podižu ugledniji pojedinci i laičke bratovštine od kojih se isticala ona Gospe od Ružarija po kojoj se i crkva tijekom 18. stoljeća pučki nazivala. Na temelju analize zapisa vizitacije nadbiskupa Evanđeliste Parzaghija iz 1670. godine, zaključuje se da je crkva netom prije njegova pohoda pregrađena, dok se prilikom opisa pojedinih oltara navodi da su u ovoj obnovi mijenjali poziciju. Godine 1678. prvi se put spominje zvonik – kampanel. Komparativnom analizom može se ustvrditi da je crkva Male Gospe u Silbi svojom tipologijom pripadala brojnoj skupini jednostavnih, prostranih, ali prema građevnim oblicima ruralnih crkava

  9. Metabolism of selective 20-epi-vitamin D3 analogs in rat osteosarcoma UMR-106 cells: Isolation and identification of four novel C-1 fatty acid esters of 1α,25-dihydroxy-16-ene-20-epi-vitamin D3.

    Science.gov (United States)

    Flarakos, Caroline Ceailles; Weiskopf, Andrew; Robinson, Matthew; Wang, Guoshun; Vouros, Paul; Sasso, Gino J; Uskokovic, Milan R; Reddy, G Satyanarayana

    2017-03-01

    Analogs of 1α,25-dihydroxyvitamin D3 (S1) with 20-epi modification (20-epi analogs) possess unique biological properties. We previously reported that 1α,25-dihydroxy-20-epi-vitamin D3 (S2), the basic 20-epi analog is metabolized into less polar metabolites (LPMs) in rat osteosarcoma cells (UMR-106) but not in a perfused rat kidney. Furthermore, we also noted that only selective 20-epi analogs are metabolized into LPMs. For example, 1α,25-dihydroxy-16-ene-20-epi-vitamin D3 (S4), but not 1α,25-dihydroxy-16-ene-23-yne-20-epi-vitamin D3 (S5) is metabolized into LPMs. In spite of these novel findings, the unequivocal identification of LPMs has not been achieved to date. We report here on a thorough investigation of the metabolism of S4 in UMR-106 cells and isolated two major LPMs produced directly from the substrate S4 itself and two minor LPMs produced from 3-epi-S4, a metabolite of S4 produced through C-3 epimerization pathway. Using GC/MS, ESI-MS and (1)H NMR analysis, we identified all the four LPMs of S4 as 25-hydroxy-16-ene-20-epi-vitamin D3-1-stearate and 25-hydroxy-16-ene-20-epi-vitamin D3-1-oleate and their respective C-3 epimers. We report here for the first time the elucidation of a novel pathway of metabolism in UMR-106 cells in which both 1α,25(OH)2-16-ene-20-epi-D3 and 1α,25(OH)2-16-ene-20-epi-3-epi-D3 undergo C-1 esterification into stearic and oleic acid esters. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Ära söö kiles saia ehk kas poliitilist kunsti on võimalik mõista? = Do not eat white bread in plastic, or is it possible to understand political art? / Ene-Liis Semper, Eero Epner

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2006-01-01

    Poliitillisest teatrist. NO99 lavastusest "Nafta" (lavastajad, autorid: Tiit Ojasoo, Ene-Liis Semper, kunstnik Ene-Liis Semper). Ettekanne Kaasaegse Kunsti Eesti Keskuse 4. ettekannete päeval "Kunstnike moraalsed valikud kultuurikonfliktides" Tallinna Kunstihoones 27.04.2006. Bibliograafia lk. 112

  11. Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes

    Energy Technology Data Exchange (ETDEWEB)

    Surendradoss, Jayakumar; Chang, Thomas K.H.; Abbott, Frank S., E-mail: frank.abbott@ubc.ca

    2012-11-01

    Valproic acid (VPA) undergoes cytochrome P450-mediated desaturation to form 4-ene-VPA, which subsequently yields (E)-2,4-diene-VPA by β-oxidation. Another biotransformation pathway involves β-oxidation of VPA to form (E)-2-ene-VPA, which also generates (E)-2,4-diene-VPA by cytochrome P450-mediated desaturation. Although the synthetic form of (E)-2,4-diene-VPA is more hepatotoxic than VPA as shown in various experimental models, there is no conclusive evidence to implicate the in situ generated (E)-2,4-diene-VPA in VPA hepatotoxicity. The present study investigated the effects of modulating the in situ formation of (E)-2,4-diene-VPA on markers of oxidative stress (formation of 2′,7′-dichlorofluorescein; DCF), steatosis (accumulation of BODIPY 558/568 C{sub 12}), necrosis (release of lactate dehydrogenase; LDH), and on cellular total glutathione (GSH) levels in sandwich-cultured rat hepatocytes treated with VPA or (E)-2-ene-VPA. Treatment with either of these chemicals alone increased each of the toxicity endpoints. In VPA-treated hepatocytes, (E)-2,4-diene-VPA was detected only at trace levels, even after phenobarbital (PB) pretreatment and there was no effect on the toxicity of VPA. Furthermore, pretreatment with a cytochrome P450 enzyme inhibitor, 1-aminobenzotriazole (1-ABT), did not influence the extent of VPA toxicity in both PB-pretreated and vehicle-pretreated hepatocytes. However, in (E)-2-ene-VPA-treated hepatocytes, PB pretreatment greatly enhanced the levels of (E)-2,4-diene-VPA and this was accompanied by a further enhancement of the effects of (E)-2-ene-VPA on DCF formation, BODIPY accumulation, LDH release, and GSH depletion. Pretreatment with 1-ABT reduced the concentrations of (E)-2,4-diene-VPA and the extent of (E)-2-ene-VPA toxicity; however, this occurred in PB-pretreated hepatocytes, but not in control hepatocytes. In conclusion, in situ generated (E)-2,4-diene-VPA is not responsible for the hepatocyte toxicity of VPA, whereas it

  12. Novel Anti-Biofouling Soft Contact Lens: l-Cysteine Conjugated Amphiphilic Conetworks via RAFT and Thiol-Ene Click Chemistry.

    Science.gov (United States)

    Zhang, Chengfeng; Liu, Ziyuan; Wang, Haiye; Feng, Xiaofeng; He, Chunju

    2017-07-01

    A unique l-cysteine conjugated antifouling amphiphilic conetwork (APCN) is synthesized through end-crosslinking of well-defined triblock copolymers poly(allyl methacrylate)-b-poly(ethylene glycol)-b-poly(allyl methacrylate) via a combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and thiol-ene "click" chemistry. The synthesized poly(ethylene glycol) macro-RAFT agent initiates the polymerization of allyl methacrylate in a controlled manner. The vinyl pendant groups of the precursor partially conjugate with l-cysteine and the rest fully crosslink with mercaptopropyl-containing siloxane via thiol-ene click chemistry under UV irradiation into APCNs, which show distinguished properties, that is, excellent biocompatibility, more than 39.6% water content, 101 barrers oxygen permeability, optimized mechanical properties, and more than 93% visible light transmittance. What's more, the resultant APCNs exhibit eminent resistance to protein adsorption, where the bovine serum albumin and lysozyme adsorption are decreased to 12 and 21 µg cm(-2) , respectively. The outstanding properties of APCNs depend on the RAFT controlled method, which precisely designs the hydrophilic/hydrophobic segments and eventually greatly improves the crosslinking efficiency and homogeneity. Meantime, the l-cysteine monolayer can effectively reduce the surface hydrophobicity and prevent protein adsorption, which exhibits the viability for antifouling surface over and under ophthalmic devices, suggesting a promising soft contact lens. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Facile one-pot preparation of a novel imidazolium-based monolith by thiol-ene click chemistry for capillary liquid chromatography.

    Science.gov (United States)

    Zhang, Peng; Yang, Haiguan; Chen, Tao; Qin, Yuemei; Ye, Fanggui

    2017-11-01

    In this work, a novel imidazolium-based monolith was fabricated through a simple route. With 1-vinyl-3-octadecylimidazolium bromide and ethylene dimethacrylate as monomers, pentaerythritol tetra-(3-mercaptopropionate) as crosslinker, AIBN as thermal initiator, the monolith was facilely fabricated by one-pot thiol-ene click chemistry. The influences of both the content of monomer/crosslinker and porogenic systems on the morphology, and permeability of the monolith were studied. The optimal reaction conditions were used to prepare a homogeneous and permeable monolith. The optimal preparation of monolithic column was characterized by scanning electron microscopy, Fourier transform infrared spectrometry, X-ray photoelectron spectroscopy, and thermogravimetric analysis. High efficiency and quick separation of alkylbenzenes, styrene and ethylbenzene, polycyclic aromatic hydrocarbon, phenols, anilines, and aromatic acids were achieved. The minimum plate height of this monolith were determined as 11.42 μm for thiourea and 13.26 μm for benzene. All results indicated that thiol-ene click chemistry provides a quick way for the fabrication of imidazolium-based monolith. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Pyriculins A and B, two monosubstituted hex-4-ene-2,3-diols and other phytotoxic metabolites produced by Pyricularia grisea isolated from buffelgrass (Cenchrus ciliaris).

    Science.gov (United States)

    Masi, Marco; Meyer, Susan; Górecki, Marcin; Mandoli, Alessandro; Di Bari, Lorenzo; Pescitelli, Gennaro; Cimmino, Alessio; Cristofaro, Massimo; Clement, Suzette; Evidente, Antonio

    2017-11-01

    Pyricularia grisea has been identified as a foliar pathogen on buffelgrass (Cenchrus ciliaris) in North America and was studied as a potential source of phytotoxins for buffelgrass control. Two monosubstituted hex-4-ene-2,3-diols, named pyriculins A and B, were isolated from its culture filtrate organic extract together with (10S,11S)-(-)-epipyriculol, trans-3,4-dihydro-3,4,8-trihydroxy-1(2H)-napthalenone, and (4S)-(+)-isosclerone. Pyriculins A and B were characterized by spectroscopic (essentially nuclear magnetic resonance [NMR], High-resolution electrospray ionization mass spectrometry [HRESIMS]) and chemical methods such as (4E)-1-(4-hydroxy-1,3-dihydroisobenzofuran-1-yl)hex-4-ene-2,3-diols. The relative and absolute configuration of these compounds was determined by a combination of spectroscopic (NMR, electronic circular dichroism [ECD]) and computational tools. When bioassayed in a buffelgrass coleoptile and radicle elongation test, (10S,11S)-(-)-epipyriculol proved to be the most toxic compound. Seed germination was much reduced and slowed with respect to the control and radicles failed to elongate. All five compounds delayed germination, but only (10S,11S)-(-)-epipyriculol was able to prevent radicle development of buffelgrass seedlings. It had no effect on coleoptile elongation, while the other four compounds caused significantly increased coleoptile development relative to the control. © 2017 Wiley Periodicals, Inc.

  15. A combination of "thiol-ene" click chemistry and surface initiated atom transfer radical polymerization: Fabrication of boronic acid functionalized magnetic graphene oxide composite for enrichment of glycoproteins.

    Science.gov (United States)

    Su, Jie; He, Xiwen; Chen, Langxing; Zhang, Yukui

    2018-04-01

    An efficient glycoproteins enrichment platform is one of vital preprocessing steps in biomarker research and in particular glycoproteomics. In this work, a well-defined boronic acid functionalized magnetic graphene oxide nanocomposite (Fe3O4-GO@PAAPBA) was synthesized for the selective enrichment of glycoproteins from complex biological samples via a novel strategy based on the "thiol-ene" click chemistry and surface initiated atom transfer radical polymerization (SI-ATRP). The initiator of ATRP was anchored to the surface of substrate through "thiol-ene" click reaction. The product Fe3O4-GO@PAAPBA was successfully synthesized in following SI-ATRP. The Fe3O4-GO@PAAPBA nanocomposite was characterized by transmission electron microscopy (TEM), Fourier transform-infrared spectroscopy (FTIR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometry (VSM) and thermogravimetric analysis. The adsorption capacity of Fe3O4-GO@PAAPBA towards ovalbumin (OVA) and transferrin (Trf) is 471mgg-1 and 450mgg-1, respectively. The nanocomposite also featured good selectivity to glycoproteins in the mixture of glycoproteins and non-glycoproteins at alkaline (pH 9.0) and physiological conditions (pH 7.4). Furthermore, it can be applied to extract glycoproteins directly from egg white samples. These results have indicated that Fe3O4-GO@PAAPBA was a potential affinity material in glycoprotein analysis. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Optimization of the surface modification process of cross-linked polythiol-coated chiral stationary phases synthesized by a two-step thiol-ene click reaction.

    Science.gov (United States)

    Schmitt, Kristina; Lämmerhofer, Michael

    2018-01-11

    A new platform technology for the preparation of stable chiral stationary phases was successfully optimized. The chiral selector tert-butylcarbamoylquinine was firstly covalently connected to the polymer poly(3-mercaptopropyl)methylsiloxane by thiol-ene click reaction. Secondly, the quinine carbamate functionalized polysiloxane conjugate was coated onto the surface of vinyl modified silica particles and cross-linked via thiol-ene click reaction. The amount of polysiloxane, chiral selector, radical initiator, reaction solvent (chloroform and methanol), reaction time, and pore size of the supporting silica particles were varied and systematically optimized in terms of achievable plate numbers while maintaining simultaneously enantioselectivity. The optimization was based on elemental analysis data, chromatographic results, and H/u-curves (Van Deemter) of the resultant chiral stationary phases. The results suggest that better chromatographic efficiency (higher plate numbers) at equal enantioselectivity can be achieved with methanol (a poor solvent for the polysiloxane that is dispersed rather than dissolved) and a lower film thickness of quinine carbamate functionalized polysiloxane. In this study, chiral stationary phases based on 100 Å silica slightly outperformed 200 Å silica particles (each 5 μm). The optimized two step material exhibited significantly reduced mass transfer resistance compared to the one step material and equal performance as a brush-type chiral stationary phase. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Kultuskirjanik Pratchett / Ene Paaver

    Index Scriptorium Estoniae

    Paaver, Ene, 1963-

    2001-01-01

    Terry Pratchetti "Mort - Surma õpipoiss" Eesti Draamateatris, lavastaja Ain Prosa. Pratchetti kohta avaldavad arvamust lavakujundaja Maret Kukkur, dramatiseerija Urmas Vadi ja laulusõnade autor Villu Kangur. Esietendus 7. juunil

  18. Whats 'App-ening'

    DEFF Research Database (Denmark)

    Ankersen, Dorit V; Weimers, Petra; Burisch, Johan

    2017-01-01

    in number. ehealth helps patients in coping with their disease by promoting self-management, which increases adherence to medical treatment and diets, and leads to an improved quality of life. For irritable bowel syndrome (IBS), there are multiple applications that provide dietary advice, for example, a low...

  19. Grunge kodukujunduses / Ene Vool

    Index Scriptorium Estoniae

    Vool, Ene, 1948-

    2004-01-01

    Low-tech, campi ja grunge ehitus- ja sisustusstiilidest meil ja mujal - kommenteerivad Andro Kööp ja Ain Nurmela. Tutvustatakse ka Mari-Mira projekti Pariisis, mis kujutab endast nn. mutant-küla, putka- ja onnikultuuri koketeriid. Artikli lõpus kommenteerib kunstiteadlane Karin Paulus grungestiili muusikas, riietuses ja sisekujunduses.

  20. Ene-Obong, HN

    African Journals Online (AJOL)

    based Oral Rehydration Solution for Home Management of Diarrhoea in Children Abstract · Vol 33, No 1 (2012) - Articles Dietary Habits and Nutritional Status of Rural School Age Children in Ebonyi State, Nigeria Abstract. ISSN: 0189-0913.

  1. Taevo Gans / Ene Ammer

    Index Scriptorium Estoniae

    Ammer, Ene

    1998-01-01

    Sisearhitekt Taevo Gansist. Tudengipõlvest, selle aja projektidest, sõpruskonnast, tandemist Summatavet & Gans, Venemaa tellimustest, kaastöölistest. Üksinda Hommilkumaal vene tarbekunsti näitusega 1974. a. 1988. a. loodud perefirmast "GaDis" (omanikud Taevo, Helle Gans, Riia Oja), mis nõustab ka "Wermot" mööbli osas. "GaDise" sisekujundusprojektidest, millega Taevo ja Helle Gans tegelevad üheskoos

  2. Sedimentación lacustre-palustre, formación de ópalos y otras silicificaciones en el Mioceno medio al sur de Villaluenga

    Directory of Open Access Journals (Sweden)

    Bustillo, Mª Angeles

    1984-08-01

    nuevas perspectivas a la interpretación y génesis de estas rocas. Las principales facies calcáreas encontradas han sido: 1 micritas complejas con laminación difusa (¿criptoalgar ?, pseudomorfos de cristales lenticulares de yesos e indicios de posibles diatomeas; 2 biomicritas con alta proporción de charáceas, moluscos y ostrácodos que se disponen con estructura laminada por acumulación de los componentes esqueléticos en niveles; 3 biomicritas con los mismos componentes anteriores, pero desorganizados, existiendo además en algún caso diatomeas; 4 pseudoesparitas y microesparitas con pseudomorfos calcáreos de cristales lenticulares de yeso; 5 margas sepiolíticas, El ambiente de sedimentación es, en general, muy superficial, de baja salinidad, calcáreo, altamente productivo, con abundante vegetación (a veces diatomeas y ocasionalmente llegan a existir períodos de exposición subaérea. Todos los tipos de facies, desde las lacustres; poco profundas a las que manifiestan subaerismo, presentan fenómenos de silicificación, aunque éstos pueden ser diferentes. Se determina que hay una silicificación penecontemporánea, discontinua que origina sólo minerales de la sílice y que puede estar relacionada con la disolución de las frústulas de diatomeas incluidas en la caliza. Muy tempranamente en la diagénesis, pero posterior a la anterior, tiene lugar una nuevas silicificación más compleja que ha originado los niveles continuos ópalo-arcillosos, homogéneos o con estructuras Liesegang, y en los que, además de los minerales exclusivamente silíceos, se ha producido Sepiolita. Se piensa que esta segunda silicificación se origina en la interfase agua-sedimento, cuando en las pequeñas depresiones, en las que se origina la sedimentación lacustre-palustre, el espesor de la lámina de agua es muy pequeña, llegando, a veces , a la desecación. Las cementaciones silíceas sobre diferentes porosidades de la roca (fenestral, pequeños huecos kársticos, etc

  3. Eesti Merenduspoliitika uuel juriidilisel ringil / Jaano Martin Ots

    Index Scriptorium Estoniae

    Ots, Jaano Martin, 1969-

    2011-01-01

    Riigikogu ei kiitnud heaks riiklikku arengukava „Eesti merenduspoliitika 2011-2020“. Kommenteerivad Ene Ergma, Toomas Haidak, Jüri Lember, Tarmo Kõuts, Annely Akkermann, Kalev Kallo, Urve Palo, Kaja Kallas

  4. Limitations of the Neurological Evolutional Exam (ENE as a motor assessment for first graders Limitações do Exame Neurológico Evolutivo (ENE como um instrumento de avaliação motora para crianças da primeira série

    Directory of Open Access Journals (Sweden)

    Priscila M. Caçola

    2010-10-01

    Full Text Available BACKGROUND: Many clinicians and researchers in Brazil consider the Neurological Developmental Exam (NDE, a valid and reliable assessment for Brazilian school-aged children. However, since its inception, several tests have emerged that, according to some researchers, provide more in-depth evaluation of motor ability and go beyond the detection of general motor status (soft neurological signs. OBJECTIVES: To highlight the limitations of the NDE as a motor skill assessment for first graders. METHODS: Thirty-five children were compared on seven selected items of the NDE, seven of the Bruininks-Oseretsky Test (BOT, and seven of the Visual-Motor Integration test (VMI. Participants received a "pass" or "fail" score for each item, as prescribed by the respective test manual. RESULTS: Chi-square and ANOVA results indicated that the vast majority of children (74% passed the NDE items, whereas values for the other tests were 29% (BOT and 20% (VMI. Analysis of specific categories (e.g. visual, fine, and gross motor coordination revealed a similar outcome. CONCLUSIONS: Our data suggest that while the NDE may be a valid and reliable test for the detection of general motor status, its use as a diagnostic/remedial tool for identifying motor ability is questionable. One of our recommendations is the consideration of a revised NDE in light of the current needs of clinicians and researchers.CONTEXTUALIZAÇÃO: Muitos clínicos e pesquisadores brasileiros consideram o Exame Neurológico Evolutivo (ENE, um instrumento válido e confiável para crianças brasileiras em idade escolar. Entretanto, desde a sua criação, surgiram outros testes para uma avaliação mais profunda de habilidade motora, os quais vão além de detectar status motor geral em forma de sinais neurológicos leves. OBJETIVOS: Demonstrar os pontos fracos do ENE como teste de avaliação de habilidade motora para crianças de primeira série. MÉTODOS: Trinta e cinco crianças realizaram 7 itens

  5. Poly[[(μ3-5,6-dicarboxybicyclo[2.2.2]oct-7-ene-2,3-dicarboxylato(1,10-phenanthrolinecopper(II] monohydrate

    Directory of Open Access Journals (Sweden)

    Ji-Cheng Ma

    2008-12-01

    Full Text Available In the title compound, {[Cu(C12H10O8(C12H8N2]·H2O}n, the CuII ion is five-coordinated by two N atoms from one phenanthroline ligand and three O atoms from three different H2L2− anions (H4L is bicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxylic acid in a distorted square-pyramidal geometry. Each H2L2− ion bridges three CuII atoms to form a zigzag sheet parallel to the ab plane. The crystal structure is consolidated by O—H...O hydrogen bonds.

  6. Çene Eklemi Rahatsızlıklarında Teşhis ve Tedavi Yöntemleri (*)

    OpenAIRE

    YENGİN, Esengün

    2013-01-01

    ÖZETÇene ekleminin fonksiyon bozukluklarında romatoid artrit, osteoartrit ve travmatik artritlerin yanı sıra ruhi bunalımlar, akut eklem romatizması, neoplazmalar ve enfeksiyöz artrit gibi hastalıklar etkili olabilmektedir. Bu hastalıkların ayırıcı teşhisinde klinik muayenenin yanı sıra, TME radyografileri, çiğneme kaslarının elektromiyografik tetkiki ile klinik ve serolojik testler yapmakta fayda vardır.Hastalarda genellikle TME tıkırtısı ve ağrısı, masseler ve dış pterigoid kaslarda ağrı, k...

  7. C(10)-C(19) bond cleavage reaction of 19-oxygenated androst-4-ene-3,6-dione steroids under various conditions.

    Science.gov (United States)

    Nagaoka, Masao; Numazawa, Mitsuteru

    2004-08-01

    C(10)-C(19) bond cleavage reaction of 19-hydroxy- and 19-oxoandrost-4-ene-3,6,17-triones (5, 6) was explored under various conditions. Treatment of steroids 5 and 6 with KOH in MeOH gave the A-ring aromatized product 6-oxoestrone (11) in a fair yield, respectively, in contrast, the treatment with a weak base yielded 4-methyl steroid 17 (20%) in the case of 19-alcohol 5 or 19-nor-Delta(5(10))-steroid 9 (12-67%) along with compound 11 (6-27%) in the case of 19-aldehyde 6. Reaction of compound 6 with HCl in MeOH produced 3-methyl ethers of 6-oxoestrone and Delta(6)-estrone, compounds 12 and 14 (ca. 20% each). Thus, 6-oxosteroids 5 and 6 showed unique C(10)-C(19) bond cleavage reactions with a base or acid.

  8. A Rapid One-Pot Synthesis of Novel High-Purity Methacrylic Phosphonic Acid (PA-Based Polyhedral Oligomeric Silsesquioxane (POSS Frameworks via Thiol-Ene Click Reaction

    Directory of Open Access Journals (Sweden)

    K. Karuppasamy

    2017-05-01

    Full Text Available Herein, we demonstrate a facile methodology to synthesis a novel methacrylic phosphonic acid (PA-functionalized polyhedral oligomeric silsesquioxanes (POSSs via thiol-ene click reaction using octamercapto thiol-POSS and ethylene glycol methacrylate phosphate (EGMP monomer. The presence of phosphonic acid moieties and POSS-cage structure in POSS-S-PA was confirmed by Fourier transform infrared (FT-IR and nuclear magnetic resonance (1H, 29Si and 31P-NMR analyses. Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF mass spectrum of POSS-S-PA acquired in a dithranol matrix, which has specifically designed for intractable polymeric materials. The observed characterization results signposted that novel organo-inorganic hybrid POSS-S-PA would be an efficacious material for fuel cells as a proton exchange membrane and high-temperature applications due to its thermal stability of 380 °C.

  9. The Molecular Structure and Vibrational Spectrum of 6-bromo-8-thia-1,4-epoxybicyclo[4.3.0]non-2-ene

    Directory of Open Access Journals (Sweden)

    Aydın Demircan

    2007-10-01

    Full Text Available Geometric parameters and FT-IR spectrum of 6-bromo-8-thia-1,4-epoxybicyclo[4.3.0]non-2-ene were computed by the HF, B3LYP, B3PW91 andmPW1PW91 methods in conjunction with the 6-31G(d,p basis set. The calculated IRspectra are in a good agreement with the observed FT-IR spectrum. A general betterperformance of B3LYP, B3PW91 and mPW1PW91 versus HF was quantitativelycharacterized by using PAVF 1.0 program. Optimal uniform scaling factors calculated forthe title compound are 0.8952, 0.9552, 0.9520 and 0.9456 for HF, B3LYP, B3PW91 andMPW1PW91 methods, respectively.

  10. One-pot synthesis of (3-sulfopropyl methacrylate potassium)-silica hybrid monolith via thiol-ene click chemistry for CEC.

    Science.gov (United States)

    Yang, Huihui; Chen, Yingzhuang; Liu, Yixuan; Nie, Lihua; Yao, Shouzhuo

    2013-02-01

    A novel (3-sulfopropyl methacrylate potassium)-silica hybrid monolithic column for CEC has been prepared by a simple one-pot approach based on efficient thiol-ene click chemistry. In this process, the polycondensation of hydrolyzed alkoxysilanes and in situ click reaction of vinyl groups on 3-sulfopropyl methacrylate potassium and thiol groups on the precondensed siloxanes simultaneously occurred in a pretreated capillary. Homogeneous monolithic matrix with large through-pores tightly bonded to the inner wall of the capillary was shown by optical microscope and SEM. The minimum plate height of this hybrid monolithic column was determined as 3.9 μm for thiourea. Anilines, alkylbenzenes, and phenols were well separated on this hybrid monolithic column by CEC, which indicated typical reversed-phase and cation-exchange chromatographic retention mechanisms of the column. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Near-field receiving water monitoring of trace metals and a benthic community near the Palo Alto Regional Water Quality Control Plant in south San Francisco Bay, California; 2016

    Science.gov (United States)

    Cain, Daniel J.; Thompson, Janet K.; Parchaso, Francis; Pearson, Sarah; Stewart, Robin; Turner, Mathew; Barasch, David; Luoma, Samuel N.

    2017-10-30

    Trace-metal concentrations in sediment and in the clam Macoma petalum (formerly reported as Macoma balthica), clam reproductive activity, and benthic macroinvertebrate community structure were investigated in a mudflat 1 kilometer south of the discharge of the Palo Alto Regional Water Quality Control Plant (PARWQCP) in south San Francisco Bay, Calif. This report includes the data collected by U.S. Geological Survey (USGS) scientists for the period January 2014 to December 2016. These append to long-term datasets extending back to 1974. A major focus of the report is an integrated description of the 2016 data within the context of the longer, multi-decadal dataset. This dataset supports the City of Palo Alto’s Near-Field Receiving Water Monitoring Program, initiated in 1994.Significant reductions in silver and copper concentrations in sediment and M. petalum occurred at the site in the 1980s following the implementation by PARWQCP of advanced wastewater treatment and source control measures. Since the 1990s, concentrations of these elements appear to have stabilized at concentrations somewhat above (silver) or near (copper) regional background concentrations Data for other metals, including chromium (Cr), mercury (Hg), nickel (Ni), selenium (Se), and zinc (Zn), have been collected since 1994. Over this period, concentrations of these elements have remained relatively constant, aside from seasonal variation that is common to all elements. In 2016, concentrations of silver and copper in M. petalum varied seasonally in response to a combination of site-specific metal exposures and annual growth and reproduction, as reported previously. Seasonal patterns for other elements, including Cr, Ni, Zn, Hg, and Se, were generally similar in timing and magnitude as those for Ag and Cu. This record suggests that legacy contamination and regional-scale factors now largely control sedimentary and bioavailable concentrations of silver and copper, as well as other elements of

  12. Preparation of polyhedral oligomeric silsesquioxane-based hybrid monolith by ring-opening polymerization and post-functionalization via thiol-ene click reaction.

    Science.gov (United States)

    Liu, Zhongshan; Ou, Junjie; Lin, Hui; Wang, Hongwei; Dong, Jing; Zou, Hanfa

    2014-05-16

    A polyhedral oligomeric silsesquioxane (POSS) hybrid monolith was simply prepared by using octaglycidyldimethylsilyl POSS (POSS-epoxy) and cystamine dihydrochloride as monomers via ring-opening polymerization. The effects of composition of prepolymerization solution and polycondensation temperature on the morphology and permeability of monolithic column were investigated in detail. The obtained POSS hybrid monolithic column showed 3D skeleton morphology and exhibited high column efficiency of ∼71,000 plates per meter in reversed-phase mechanism. Owing to this POSS hybrid monolith essentially possessing a great number of disulfide bonds, the monolith surface would expose thiol groups after reduction with dithiothreitol (DTT), which supplied active sites to functionalize with various alkene monomers via thiol-ene click reaction. The results indicated that the reduction with DTT could not destroy the 3D skeleton of hybrid monolith. Both stearyl methylacrylate (SMA) and benzyl methacrylate (BMA) were selected to functionalize the hybrid monolithic columns for reversed-phase liquid chromatography (RPLC), while [2-(methacryloyloxy)ethyl]-dimethyl-(3-sulfopropyl)-ammonium hydroxide (MSA) was used to modify the hybrid monolithic column in hydrophilic interaction chromatography (HILIC). These modified hybrid monolithic columns could be successfully applied for separation of small molecules with high efficiency. It is demonstrated that thiol-ene click reaction supplies a facile way to introduce various functional groups to the hybrid monolith possessing thiol groups. Furthermore, due to good permeability of the resulting hybrid monoliths, we also prepared long hybrid monolithic columns in narrow-bore capillaries. The highest column efficiency reached to ∼70,000 plates using a 1-m-long column of 75μm i.d. with a peak capacity of 147 for isocratic chromatography, indicating potential application in separation and analysis of complex biosamples. Copyright © 2014

  13. Liquid chromatography–tandem mass spectrometry method for simultaneous determination of valproic acid and its ene-metabolites in epilepsy patient plasma

    Directory of Open Access Journals (Sweden)

    Huan Lu

    2016-04-01

    Full Text Available A simple and high throughput method was developed and validated for simultaneous determination of valproic acid and its two toxicant ene-metabolites, 2-enevalproic acid and 4-enevalproic acid in epilepsy patient plasma using liquid chromatography–tandem mass spectrometry. Probenecid was used as internal standard and solid-phase extraction was selected for sample preparation. A chromatographic separation was performed on an Agilent Poroshell SB-C18 column (50 mm×4.6 mm i.d., 2.7 μm by an optimized gradient elution at a flow rate of 0.9 mL/min. The total run time was 7 min. Electrospray ionization was used in negative ion mode by multiple reaction monitoring of the precursor-to-product ion transitions at m/z 143.0→143.0 for valproic acid, m/z 140.9→140.9 for 2-enevalproic acid and 4-enevalproic acid for their poor fragments, and m/z 283.9→239.9 for probenecid. The results showed good linearity of valproic acid, 2-enevalproic acid and 4-enevalproic acid in their respective linear ranges. The correlation coefficients were more than 0.998. The intra- and inter-day precision of the assay was less than 11.0% and the accuracy ranged from 2% to 12%. This analytical method was successfully applied to assay plasma concentrations of valproic acid and its two ene-metabolites in epilepsy patient plasma and used for therapeutic drug monitoring.

  14. Eksperimentalno ispitivanje aerodinamičkih karakteristika modela laserski vođene bombe / Experimental investigation of aerodynamic characteristics of the laser guided bomb model

    Directory of Open Access Journals (Sweden)

    Dijana Damljanović

    2005-09-01

    Full Text Available U radu su prikazani rezultati merenja aerodinamičkih sila i momenata, kao i vizualizacija strujanja u graničnom sloju na krilima i krmilima modela laserski vođene bombe. Ispitivanje je izvršeno u aerotunelu T-38. Analiziranje uticaj rastojanja vrha konusa tela, u odnosu na sekciju krmila, na aerodinamičke karakteristike modela za dva Mahova broja M∞ = 0,8 i 0,9 i otklon krmila δ=15°. Normalne sile koje se javljaju na modelu i krmilu merene su unutrašnjim aerovagama. Dobijeni rezultati merenja normalne sile na modelu i posebno na krmilu povezani su sa rezultatima vizualizacije strujanja metodom uljnih premaza. Priložene fotografije vizualizacije strujanja ilustruju promene strujanja oko modela i potvrđuju rezultate aerodinamičkih merenja. / Aerodynamic test results and boundary layer flow visualization on the wings and fins of laser guided bomb model are presented in this article. Test was performed in the T-38 wind tunnel. Influence of fin position relative to conic top of the model on aerodynamic characteristics was analyzed. Analysis was performed on aerodynamic characteristics of the model for two Mach numbers M∞ = 0,8 and 0,9 and fin deflection δ=15°. Normal forces present on the model and fin were measured by internal strain gauge balances. Obtained test results of normal force on the model and especially on the fin were associated with flow visualization results, which were performed by oil emulsion method. Presented images of flow visualization show changes of the flow around the model and confirm the results of the aerodynamic measurements.

  15. One-pot preparation of glutathione-silica hybrid monolith for mixed-mode capillary liquid chromatography based on "thiol-ene" click chemistry.

    Science.gov (United States)

    Lin, Zian; Tan, Xiaoqing; Yu, Ruifang; Lin, Jiashi; Yin, Xiaofei; Zhang, Lan; Yang, Huanghao

    2014-08-15

    A novel glutathione (GSH)-silica hybrid monolithic column synthesized via a combination of thiol-ene click reaction and one-pot process was described, where thiol-end GSH organic monomer and 2,2-azobisisobutyronitrile (AIBN) were mixed with hydrolyzed tetramethyloxysilane (TMOS) and γ-methacryloxypropyltrimethoxysilane (γ-MAPS) and then introduced into a fused-silica capillary for simultaneous polycondensation and "thiol-ene" click reaction to form the GSH-silica hybrid monolith. The effects of the molar ratio of TMOS/γ-MAPS, the amount of GSH, and the volume of porogen on the morphology, permeability and pore properties of the prepared GSH-silica hybrid monoliths were studied in detail. A uniform monolithic network with high porosity was obtained. A series of test compounds including alkylbenzenes, amides, and anilines were used to evaluate the retention behaviors of the GSH-silica hybrid monolithic column. The results demonstrated that the prepared GSH-silica hybrid monolith exhibited multiple interactions including hydrophobicity, hydrophilicity, as well as cation exchange interaction. The run-to-run, column-to-column and batch-to-batch reproducibilities of the GSH-silica hybrid monolith for phenols' retention were satisfactory with the relative standard deviations (RSDs) less than 1.3% (n=5), 2.6% (n=3) and 3.2% (n=3), respectively, indicating the effectiveness and practicability of the proposed method. In addition, the GSH-silica hybrid monolith was applied to the separation of nucleotides, peptides and protein tryptic digests, respectively. The successful applications suggested the potential of the GSH-silica hybrid monolith in complex sample analysis. Copyright © 2014 Elsevier B.V. All rights reserved.

  16. Liquefaction Hazard Maps for Three Earthquake Scenarios for the Communities of San Jose, Campbell, Cupertino, Los Altos, Los Gatos, Milpitas, Mountain View, Palo Alto, Santa Clara, Saratoga, and Sunnyvale, Northern Santa Clara County, California

    Science.gov (United States)

    Holzer, Thomas L.; Noce, Thomas E.; Bennett, Michael J.

    2008-01-01

    Maps showing the probability of surface manifestations of liquefaction in the northern Santa Clara Valley were prepared with liquefaction probability curves. The area includes the communities of San Jose, Campbell, Cupertino, Los Altos, Los Gatos Milpitas, Mountain View, Palo Alto, Santa Clara, Saratoga, and Sunnyvale. The probability curves were based on complementary cumulative frequency distributions of the liquefaction potential index (LPI) for surficial geologic units in the study area. LPI values were computed with extensive cone penetration test soundings. Maps were developed for three earthquake scenarios, an M7.8 on the San Andreas Fault comparable to the 1906 event, an M6.7 on the Hayward Fault comparable to the 1868 event, and an M6.9 on the Calaveras Fault. Ground motions were estimated with the Boore and Atkinson (2008) attenuation relation. Liquefaction is predicted for all three events in young Holocene levee deposits along the major creeks. Liquefaction probabilities are highest for the M7.8 earthquake, ranging from 0.33 to 0.37 if a 1.5-m deep water table is assumed, and 0.10 to 0.14 if a 5-m deep water table is assumed. Liquefaction probabilities of the other surficial geologic units are less than 0.05. Probabilities for the scenario earthquakes are generally consistent with observations during historical earthquakes.

  17. The effect of 3β, 6β, 16β-trihydroxylup-20(29)-ene lupane compound isolated from Combretum leprosum Mart. on peripheral blood mononuclear cells.

    Science.gov (United States)

    Lacouth-Silva, Fabianne; Xavier, Caroline V; da S Setúbal, Sulamita; Pontes, Adriana S; Nery, Neriane M; de Castro, Onassis Boeri; Fernandes, Carla F C; Honda, Eduardo R; Zanchi, Fernando B; Calderon, Leonardo A; Stábeli, Rodrigo G; Soares, Andreimar M; Silva-Jardim, Izaltina; Facundo, Valdir A; Zuliani, Juliana P

    2015-11-25

    The Combretum leprosum Mart. plant, popularly known as mofumbo, is used in folk medicine for inflammation, pain and treatment of wounds. From this species, it is possible to isolate three triterpenes: (3β, 6β, 16β-trihydroxylup-20(29)-ene) called lupane, arjunolic acid and molic acid. In this study, through preclinical tests, the effect of lupane was evaluated on the cytotoxicity and on the ability to activate cellular function by the production of TNF-α, an inflammatory cytokine, and IL-10, an immuno regulatory cytokine was assessed. The effect of lupane on the enzymes topoisomerase I and II was also evaluated. For this reason, peripheral blood mononuclear cells (PBMCs) were obtained and cytotoxicity was assessed by the MTT method at three different times (1, 15 and 24 h), and different concentrations of lupane (0.3, 0.7, 1.5, 6, 3 and 12 μg/mL). The cell function was assessed by the production of TNF-α and IL-10 by PBMCs quantified by specific enzyme immunoassay (ELISA). The activity of topoisomerases was assayed by in vitro biological assays and in silico molecular docking. The results obtained showed that lupane at concentrations below 1.5 μg/mL was not toxic to the cells. Moreover, lupane was not able to activate cellular functions and did not alter the production of IL-10 and TNF-α. Furthermore, the data showed that lupane has neither interfered in the action of topoisomerase I nor in the action of topoisomerase II. Based on preclinical results obtained in this study, we highlight that the compound studied (lupane) has moderate cytotoxicity, does not induce the production of TNF-α and IL-10, and does not act on human topoisomerases. Based on the results of this study and taking into consideration the reports about the anti-inflammatory and leishmanicidal activity of 3β, 6β, 16β-trihydroxylup-20(29)-ene, we suggest that this compound may serve as a biotechnological tool for the treatment of leishmaniasis in the future.

  18. Origin and palaeoenvironmental significance of C25 and C27n-alk-1-enes in a 25,000-year lake-sedimentary record from equatorial East Africa

    Science.gov (United States)

    van Bree, L. G. J.; Rijpstra, W. I. C.; Cocquyt, C.; Al-Dhabi, N. A.; Verschuren, D.; Sinninghe Damsté, J. S.; de Leeuw, J. W.

    2014-11-01

    We studied the distribution of long-chain alkenes (n-C23 to n-C31) in well-dated sediments from Lake Challa, a deep crater lake near Mt. Kilimanjaro in equatorial East Africa, to reveal signatures of palaeo-environmental and palaeo-climatic changes affecting the production of these compounds during the last 25 kyr. The apolar fractions of organic sediment extracts dated to the last 16 kyr showed an unusual dominance of δ13C-depleted n-C25:1 and n-C27:1 alk-1-enes. These alkenes were not detected in soil and litter from near the shoreline and from the inner rim of the crater, pointing to an autochthonous, aquatic source. Analysis of suspended particulate matter indicated that the n-alk-1-enes are produced in the well-oxygenated upper 30 m of the water column, indicating a phytoplanktonic origin. Sedimenting particles collected monthly from December 2006 to November 2007 showed increased fluxes of n-alk-1-enes following the locally prominent short rain season in November-December. Green algae and/or cyanobacteria were identified as candidate sources of these alkenes. Production of the n-C25:1 and n-C27:1 alkenes in Lake Challa was much reduced during the Last Glacial Maximum and early late-glacial period, suggesting a temperature or CO2 effect on habitat suitability. We explored the potential of n-alk-1-ene accumulation rates, and of a derived Alkene Index [n-C27:1]/([n-C25:1] + [n-C27:1]), to record longer-term climatic changes. The Alkene Index record of Lake Challa over the past 25 kyr shows clear periodicity with a dominant frequency of ∼2.3 kyr, potentially indicative of monsoon variability directly or indirectly forced by variation in solar radiation.

  19. Effects of Bisphenol A Metabolite 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene on Lung Function and Type 2 Pulmonary Alveolar Epithelial Cell Growth.

    Science.gov (United States)

    Liu, Shing-Hwa; Su, Chin-Chuan; Lee, Kuan-I; Chen, Ya-Wen

    2016-12-16

    Bisphenol A (BPA) is recognized as a major pollutant worldwide. 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) is a major active metabolite of BPA. The epidemiological and animal studies have reported that BPA is harmful to lung function. The role of MBP in lung dysfunction after BPA exposure still remains unclear. This study investigated whether MBP would induce lung alveolar cell damage and evaluated the role of MBP in the BPA exposure-induced lung dysfunction. An in vitro type 2 alveolar epithelial cell (L2) model and an ex vivo isolated reperfused rat lung model were used to determine the effects of BPA or MBP on cell growth and lung function. MBP, but not BPA, dose-dependently increased the mean artery pressure (Pa), pulmonary capillary pressure (Pc), pulmonary capillary filtration coefficient (Kfc), and wet/dry weight ratio in isolated reperfused rat lungs. MBP significantly reduced cell viability and induced caspases-3/7 cleavage and apoptosis and increased AMP-activated protein kinas (AMPK) phosphorylation and endoplasmic reticulum (ER) stress-related molecules expression in L2 cells, which could be reversed by AMPK-siRNA transfection. These findings demonstrated for the first time that MBP exposure induced type 2 alveolar cell apoptosis and lung dysfunction through an AMPK-regulated ER stress signaling pathway.

  20. Fast preparation of a highly efficient organic monolith via photo-initiated thiol-ene click polymerization for capillary liquid chromatography.

    Science.gov (United States)

    Chen, Lianfang; Ou, Junjie; Liu, Zhongshan; Lin, Hui; Wang, Hongwei; Dong, Jing; Zou, Hanfa

    2015-05-15

    A novel organic monolith was firstly prepared in a UV-transparent fused-silica capillary by a single-step approach via photo-initiated thiol-ene click polymerization reaction of 1,2,4-trivinylcyclohexane (TVCH) and pentaerythriol tetra(3-mercaptopropionate) (4SH) within 10min. The effects of both composition of prepolymerization solution and polymerization time on the morphology and permeability of monolithic column were investigated in detail. Then, the optimal condition was acquired to fabricate a homogeneous and permeable organic monolith. The chemical groups of the monolithic column were confirmed by Fourier transform infrared spectroscopy (FT-IR). The SEM graphs showed the organic monolith possessed a uniform porous structure, which promotes the highest column efficiency of ∼133,000 plates per meter for alkylbenzenes at the linear velocity of 0.65mm/s in reversed-phase liquid chromatography. Finally, the organic monolithic column was further applied for separation of basic compounds, pesticides and EPA610, indicating satisfactory separation ability. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. The synthesis of weak acidic type hybrid monolith via thiol-ene click chemistry and its application in hydrophilic interaction chromatography.

    Science.gov (United States)

    Zeng, Jiao; Liu, Shengquan; Wang, Menglin; Yao, Shouzhuo; Chen, Yingzhuang

    2017-05-01

    In this work, a porous structure and good permeability monolithic column was polymerized in UV transparent fused-silica capillaries via photo-initiated thiol-ene click polymerization of 2,4,6,8-tetravinyl-2,4,6,8-tetramethylcyclotetrasiloxane (TMTVS), pentaerythritol tetra(3-mercaptopropionate)(PETMP), itaconic acid, respectively, in the presence of porogenic solvents (tetrahydrofuranand methanol) and an initiator (2,2-dimethoxy-2-phenylacetophenone) (DMPA) within 30 min. The physical properties of this monolith were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and nitrogen adsorption/desorption measurements. For an overall evaluation of the monolith in chromatographic application, separations of polycyclic aromatic hydrocarbons (PAHs), phenols, amides and bases were carried out. The column efficiency of this monolith could be as high as 112 560 N/m. It also possesses a potential application in fabrication of monoliths with high efficiency for c-LC. In addition, the resulting monolithic column demonstrated the potential use in analysis of environment waters. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Occurrence of (Z)-3,4-Dideoxyglucoson-3-ene in Different Types of Beer and Malt Beer as a Result of 3-Deoxyhexosone Interconversion.

    Science.gov (United States)

    Hellwig, Michael; Nobis, Arndt; Witte, Sophia; Henle, Thomas

    2016-04-06

    In beer, 3-deoxyglucosone (3-DG) and 3-deoxygalactosone (3-DGal) are important sugar degradation products, but little is known about the relevance of the interconversion reaction between these compounds in different types of beer. In the present study, 3-DG was quantitated at concentrations of 12.9-52.7 mg/L and 3-DGal at concentrations of 6.0-26.4 mg/L in different types of beer (pilsner, wheat, bock, dark, and alcohol-free beers). The concentrations in malt beer tended to be higher. Largely overlapping concentration ranges precluded a classification of beers by their 3-deoxyglycosone contents. 3,4-Dideoxyglucoson-3-ene (3,4-DGE) was identified as an important intermediate and quantitated in beer and malt beer for the first time. The E and Z isomers of the corresponding quinoxaline were synthesized by a new synthetic approach and isolated by semipreparative HPLC. An assay was developed for quantitation of (E)- and (Z)-3,4-DGE by HPLC-MS/MS, and the Z isomer was determined at concentrations of 0.3-1.7 mg/L in beer and 0.5-4.8 mg/L in malt beer samples. The E isomer was shown to be of little importance. Concentrations of 5-hydroxymethylfurfural (HMF) were twice as high as those of (Z)-3,4-DGE in beer samples (0.4-3.7 mg/L) but much higher in malt beer samples (1.6-336 mg/L).

  3. "One-step" preparation of thiol-ene clickable PEG-based thermoresponsive hyperbranched copolymer for in situ crosslinking hybrid hydrogel.

    Science.gov (United States)

    Dong, Yixiao; Saeed, Aram Omer; Hassan, Waqar; Keigher, Catherine; Zheng, Yu; Tai, Hongyun; Pandit, Abhay; Wang, Wenxin

    2012-01-01

    A well-defined poly(ethylene glycol) based hyperbranched thermoresponsive copolymer with high content of acrylate vinyl groups was synthesized via a "one-pot and one-step" deactivation enhanced atom transfer radical polymerization approach, which provided an injectable and in situ crosslinkable system via Michael-type thiol-ene reaction with a thiol-modified hyaluronan biopolymer. The hyperbranched structure, molecular weight, and percentage of vinyl content of the copolymer were characterized by gel permeation chromatography and (1)H NMR. The lower critical solution temperature of this copolymer is close to body temperature, which can result in a rapid thermal gelation at 37 °C. The scanning electron microscopy analysis of crosslinked hydrogel showed the network formation with porous structure, and 3D cell culture study demonstrated the good cell viability after the cells were embedded inside the hydrogel. This injectable and in situ crosslinking hybrid hydrogel system offers great promise as a new class of hybrid biomaterials for tissue engineering. Copyright © 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Critical Parameters and Critical-Region (p,ρ ,T) Data of trans-1,1,1,3-Tetrafluorobut-2-ene [HFO-1354mzy(E)

    Science.gov (United States)

    Kimura, Takeru; Kayukawa, Yohei; Miyamoto, Hiroyuki; Saito, Kiyoshi

    2017-08-01

    This study presents the experimental measurement of the pρ T properties and critical parameters of a low GWP type refrigerant, trans-1,1,1,3-Tetrafluorobut-2-ene (HFO-1354mzy(E)). The sample purity of the substance was 99 area %. p ρ T property measurements and visual observations of the meniscus of HFO-1354mzy(E) were carried out using a metal-bellows volumometer with an optical cell. The critical temperature was determined by observation of the critical opalescence. The critical pressure and critical density were determined as the inflection point of the isothermal p ρ T property data at the critical temperature. For more precise clarification of the thermodynamic surface in the vicinity of the critical point, additional p ρ T property measurements were carried out on three isotherms in the supercritical region. The expanded uncertainties (k = 2) in the temperature, pressure, and density measurements were estimated to be less than 3 mK, 1.2 kPa, and 0.32 \\hbox {kg} \\cdot \\hbox {m}^{-3}, respectively. The expanded uncertainties of the critical parameters were estimated to be less than 13 mK, 1.4 kPa, and 2.3 \\hbox {kg} \\cdot \\hbox {m}^{-3}, respectively. These values are the first reported for HFO-1354mzy(E) and are necessary for the development of its equation of state in the near future.

  5. Thiol-ene immobilisation of carbohydrates onto glass slides as a simple alternative to gold-thiol monolayers, amines or lipid binding.

    Science.gov (United States)

    Biggs, Caroline I; Edmondson, Steve; Gibson, Matthew I

    2015-01-01

    Carbohydrate arrays are a vital tool in studying infection, probing the mechanisms of bacterial, viral and toxin adhesion and the development of new treatments, by mimicking the structure of the glycocalyx. Current methods rely on the formation of monolayers of carbohydrates that have been chemically modified with a linker to enable interaction with a functionalised surface. This includes amines, biotin, lipids or thiols. Thiol-addition to gold to form self-assembled monolayers is perhaps the simplest method for immobilisation as thiolated glycans are readily accessible from reducing carbohydrates in a single step, but are limited to gold surfaces. Here we have developed a quick and versatile methodology which enables the use of thiolated carbohydrates to be immobilised as monolayers directly onto acrylate-functional glass slides via a 'thiol-ene'/Michael-type reaction. By combining the ease of thiol chemistry with glass slides, which are compatible with microarray scanners this offers a cost effective, but also useful method to assemble arrays.

  6. IN0523 (Urs-12-ene-3α,24β-diol) a plant based derivative of boswellic acid protect Cisplatin induced urogenital toxicity.

    Science.gov (United States)

    Singh, Amarinder; Arvinda, S; Singh, Surjeet; Suri, Jyotsna; Koul, Surinder; Mondhe, Dilip M; Singh, Gurdarshan; Vishwakarma, Ram

    2017-03-01

    The limiting factor for the use of Cisplatin in the treatment of different type of cancers is its toxicity and more specifically urogenital toxicity. Oxidative stress is a well-known phenomenon associated with Cisplatin toxicity. However, in Cisplatin treated group, abnormal animal behavior, decreased body weight, cellular and sub-cellular changes in the kidney and sperm abnormality were observed. Our investigation revealed that Cisplatin when administered in combination with a natural product derivative (Urs-12-ene-3α,24β-diol, labeled as IN0523) resulted in significant restoration of body weight and protection against the pathological alteration caused by Cisplatin to kidney and testis. Sperm count and motility were significantly restored near to normal. Cisplatin caused depletion of defense system i.e. glutathione peroxidase, catalase and superoxide dismutase, which were restored close to normal by treatment of IN0523. Reduction in excessive lipid peroxidation induced by Cisplatin was also found by treatment with IN0523. The result suggests that IN0523 is a potential candidate for ameliorating Cisplatin induced toxicity in the kidney and testes at a dose of 100mg/kg p.o. via inhibiting the oxidative stress/redox status imbalance and may be improving the efflux mechanism. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Preparation and characterization of hydrophilic hybrid monoliths via thiol-ene click polymerization and their applications in chromatographic analysis and glycopeptides enrichment.

    Science.gov (United States)

    Bai, Jingyao; Liu, Zhongshan; Wang, Hongwei; You, Xin; Ou, Junjie; Shen, Yehua; Ye, Mingliang

    2017-05-19

    A macroporous hydrophilic organic-silica hybrid monolithic column was synthesized via photoinitiated thiol-ene click polymerization reaction of 1-thioglycerol-modified polyhedral oligomeric vinylsilsesquioxane (vinylPOSS) and dithiothreitol (DTT) in a binary porogenic system consisting of tetrahydrofuran (THF) and dodecanol. 1-Thioglycerol was used to modify vinylPOSS in order to form a precursor with good solubility in the binary porogenic system. The influences of both the ratio of 1-thioglycerol/vinylPOSS and the porogenic solvents on the morphology and permeability of hybrid monoliths were studied in detail. The physical properties of hybrid monolith were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and nitrogen adsorption/desorption measurement. The chromatographic performance was evaluated by separation of neutral polar compounds in capillary liquid chromatography (cLC). The resulting column possessed homogeneous macroporous structure and showed hydrophilic interaction liquid chromatography (HILIC) separation mechanism with high efficiency of 65,000Nm -1 for formamide. Ultimately, the hybrid matrix was grafted with hydrazine groups and then exhibited the ability of glycopeptides enrichment. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. One-Pot Multicomponent Synthesis of Glycopolymers through a Combination of Host-Guest Interaction, Thiol-ene, and Copper-Catalyzed Click Reaction in Water.

    Science.gov (United States)

    Hu, Xiang; Gao, Jinbo; Luo, Yan; Wei, Ting; Dong, Yishi; Chen, Gaojian; Chen, Hong

    2017-10-01

    There is a common phenomenon that the heterogeneity of natural oligosaccharides contains various sugar units, which can be used to enhance affinity and selectivity toward a specific receptor, so the synthesis of heterogeneous glycopolymers is always an important issue in the glycopolymer field. Herein, this study conducts a one-pot method to prepare polyrotaxane-based heteroglycopolymers anchored with different sugar units and fluorescent moieties via the combination of host-guest interaction, thiol-ene, and copper-catalyzed click chemistry in water. Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, gel permeation chromatography, X-ray diffraction, and Ellman's assay test are used in the paper to characterize the compounds. Quartz crystal microbalance-dissipation (QCD-D) experiments and bacterial adhesion assay are utilized to study the interactions of polyrotaxane-based heteroglycopolymers with Con A and Escherichia coli. The results reveal that polyrotaxanes (PRs) with mannose and glucose present better specificity toward Con A and E. coli than PRs with glucose due to synergistic effects. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. One-pot preparation of mercaptotetrazole-silica hybrid monoliths by the thiol-ene click reaction for mixed-mode capillary liquid chromatography.

    Science.gov (United States)

    Wang, Haojiang; Hu, Wenli; Zheng, Qiong; Bian, Wei; Lin, Zian

    2017-06-01

    A novel mercaptotetrazole-silica hybrid monolithic column was prepared for capillary liquid chromatography, in which the thiol-end mercaptotetrazole was mixed with hydrolyzed γ-methacryloxypropyltrimethoxysilane and tetramethyloxysilane for the co-polycondensation and thiol-ene click reaction in a one-pot process. The effects of the molar ratio of silanes, the amount of mercaptotetrazole, and the volume of porogen on the morphology, permeability and pore properties of the as-prepared mercaptotetrazole-silica hybrid monoliths were investigated in detail. A series of test compounds including alkylbenzenes, amides and anilines were employed for evaluating the retention behaviors of the mercaptotetrazole-silica hybrid monolithic columns. The results demonstrated that the mercaptotetrazole-silica hybrid monoliths exhibited hydrophobic, hydrophilic as well as ion-exchange interaction. The run-to-run, column-to-column and batch-to-batch reproducibilities of the mercaptotetrazole-silica hybrid monoliths were satisfactory with the relative standard deviations less than 1.4 (n = 5), 3.9 (n = 3) and 4.0% (n = 5), respectively. In addition, the mercaptotetrazole-silica hybrid monolith was further applied to the separation of sulfonamides, nucleobases and protein tryptic digests. These successful applications confirmed the promising potential of the mercaptotetrazole-silica hybrid monolith in the separation of complex samples. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Facile "one-pot" synthesis of poly(methacrylic acid)-based hybrid monolith via thiol-ene click reaction for hydrophilic interaction chromatography.

    Science.gov (United States)

    Lv, Xumei; Tan, Wangming; Chen, Ye; Chen, Yingzhuang; Ma, Ming; Chen, Bo; Yao, Shouzhuo

    2016-07-08

    A novel sol-gel "one-pot" approach in tandem with a radical-mediated thiol-ene reaction for the synthesis of a methacrylic acid-based hybrid monolith was developed. The polymerization monomers, tetramethoxysilane (TMOS) and 3-mercaptopropyl trimethoxysilane (MPTS), were hydrolyzed in high-concentration methacrylic acid solution that also served as a hydrophilic functional monomer. The resulting solution was then mixed with initiator (2, 2'-azobis (2-methylpropionamide) dihydrochloride) and porogen (urea, polyethylene glycol 20,000) in a capillary column and polymerized in water bath. The column had a uniform porous structure and a good permeability. The evaluation of the monolith was performed by separation of small molecules including nucleosides, phenols, amides, bases and Triton X-100. The calibration curves for uridine, inosine, adenosine and cytidine were determined. All the calibration curves exhibited good linear regressions (R(2)≥0.995) within the test ranges of 0.5-40μg/mL for four nucleosides. Additionaliy, atypical hydrophilic mechanism was proved by elution order from low to high according to polarity retention time increased with increases in the content of the organic solvent in the mobile phase. Further studies indicated that hydrogen bond and electrostatic interactions existed between the polar analytes and the stationary phase. This was the mechanism of retention. The excellent separation of the BSA digest showed good hydrophility of the column and indicated the potential in separation of complex biological samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Crystal and Molecular Structure Studies of Ethyl 4-(4-Hydroxyphenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate and Ethyl 4-(3-Bromophenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate

    Directory of Open Access Journals (Sweden)

    Badiadka Narayana

    2012-08-01

    Full Text Available The crystal and molecular structures of the title compounds, ethyl 4-(4-hydroxyphenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate (I and ethyl 4-(3-bromophenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate (II, are reported and confirmed by single crystal X-ray diffraction data. Compound (I, C26H24O5, crystallizes from a methanol solution in the monoclinic C2/c space group with eight molecules in the unit cell. The unit cell parameters are: a = 25.4114(5 Å, b = 8.47440(10 Å, c = 20.6921(4 Å, β = 108.328(2° and V = 4229.92(13 Å3. Disorder is observed throughout the entire molecule with an occupancy ratio 0.690(2:0.310(2. Compound (II, C26H23O4Br, crystallizes from an ethyl acetate solution in the monoclinic P21/c spacegroup with four molecules in the unit cell. The unit cell parameters are a = 17.8991(9 Å, b = 11.4369(6 Å, c = 10.8507(5 Å, β = 92.428(4° and V = 2219.25(19 Å3. Disorder is observed in the cyclohexenone ring and the carboxylate group with an occupancy ratio 0.830(6:0.170(6. Weak O–H...O (I or C–H...O (II intermolecular interactions are observed which influence crystal packing stability. These chalcone derivative types of molecules are important in their ability to act as activated unsaturated systems in conjugated addition reactions of carbanions in the presence of basic catalysts which exhibit a multitude of biological activities.

  12. Near-field receiving water monitoring of trace metals and a benthic community near the Palo Alto Regional Water Quality Control Plant in South San Francisco Bay, California: 2013

    Science.gov (United States)

    Dyke, Jessica; Cain, Daniel J.; Thompson, Janet K.; Kleckner, Amy E.; Parcheso, Francis; Hornberger, Michelle I.; Luoma, Samuel N.

    2014-01-01

    Trace-metal concentrations in sediment and in the clam Macoma petalum (formerly reported as Macoma balthica), clam reproductive activity, and benthic macroinvertebrate community structure were investigated in a mudflat 1 kilometer south of the discharge of the Palo Alto Regional Water Quality Control Plant (PARWQCP) in South San Francisco Bay, Calif. This report includes the data collected by U.S. Geological Survey (USGS) scientists for the period January 2013 to December 2013. These data serve as the basis for the City of Palo Alto’s Near-Field Receiving Water Monitoring Program, initiated in 1994. Following significant reductions in the late 1980s, silver (Ag) and copper (Cu) concentrations in sediment and M. petalum appear to have stabilized. Data for other metals, including chromium (Cr), mercury (Hg), nickel (Ni), selenium (Se), and zinc (Zn), have been collected since 1994. Over this period, concentrations of these elements have remained relatively constant, aside from seasonal variation that is common to all elements. In 2013, concentrations of Ag and Cu in M. petalum varied seasonally in response to a combination of site-specific metal exposures and annual growth and reproduction, as reported previously. Seasonal patterns for other elements, including Cr, Ni, Zn, Hg, and Se, were generally similar in timing and magnitude as those for Ag and Cu. In M. petalum, all observed elements showed annual maxima in January–February and minima in April, except for Zn, which was lowest in December. In sediments, annual maxima also occurred in January–February, and minima were measured in June and September. In 2013, metal concentrations in both sediments and clam tissue were among the lowest concentrations on record. This record suggests that regional-scale factors now largely control sedimentary and bioavailable concentrations of Ag and Cu, as well as other elements of regulatory interest, at the Palo Alto site. Analyses of the benthic community structure of a

  13. Near-field receiving water monitoring of trace metals and a benthic community near the Palo Alto Regional Water Quality Control Plant in south San Francisco Bay, California, 2012

    Science.gov (United States)

    Dyke, Jessica; Thompson, Janet K.; Cain, Daniel J.; Kleckner, Amy E.; Parcheso, Francis; Luoma, Samuel N.; Hornberger, Michelle I.

    2013-01-01

    Trace-metal concentrations in sediment and in the clam Macoma petalum (formerly reported as Macoma balthica), clam reproductive activity, and benthic macroinvertebrate community structure were investigated in a mudflat 1 kilometer south of the discharge of the Palo Alto Regional Water Quality Control Plant (PARWQCP) in South San Francisco Bay, Calif. This report includes the data collected by U.S. Geological Survey (USGS) scientists for the period January to December 2012. These data serve as the basis for the City of Palo Alto’s Near-Field Receiving Water Monitoring Program, initiated in 1994. Following significant reductions in the late 1980s, silver (Ag) and copper (Cu) concentrations in sediment and in M. petalum appear to have stabilized. Data for other metals, including chromium (Cr), mercury (Hg), nickel (Ni), selenium (Se), and zinc (Zn), have been collected since 1994. Over this period, concentrations of these elements have remained relatively constant, aside from seasonal variation that is common to all elements. In 2012, concentrations of Ag and Cu in M. petalum varied seasonally in response to a combination of site-specific metal exposures and annual growth and reproduction, as reported for previous time periods. Seasonal patterns for other elements, including Cr, Ni, Zn, Hg, and Se were generally similar in timing and magnitude as those for Ag and Cu. In 2012, metal concentrations in both sediments and clam tissue were among the lowest concentrations on record. This record suggests that regional-scale factors now largely control sedimentary and bioavailable concentrations of Ag and Cu, as well as other elements of regulatory interest, at the Palo Alto site. Analyses of the benthic community structure of a mudflat in South San Francisco Bay over a 39-year period show that changes in the community have occurred concurrent with reduced concentrations of metals in the sediment and in the tissues of the biosentinel clam, M. petalum, from the same area

  14. Near-field receiving water monitoring of trace metals and a benthic community near the Palo Alto Regional Water Quality Control Plant in south San Francisco Bay, California: 2011

    Science.gov (United States)

    Dyke, Jessica; Thompson, Janet K.; Cain, Daniel J.; Kleckner, Amy E.; Parcheso, Francis; Luoma, Samuel N.; Hornberger, Michelle I.

    2012-01-01

    Trace-metal concentrations in sediment and in the clam Macoma petalum (formerly reported as Macoma balthica), clam reproductive activity, and benthic macroinvertebrate community structure were investigated in a mudflat 1 kilometer south of the discharge of the Palo Alto Regional Water Quality Control Plant (PARWQCP) in South San Francisco Bay, Calif. This report includes the data collected by U.S. Geological Survey (USGS) scientists for the period January 2011 to December 2011. These data serve as the basis for the City of Palo Alto's Near-Field Receiving Water Monitoring Program, initiated in 1994. Following significant reductions in the late 1980s, silver (Ag) and copper (Cu) concentrations in sediment and M. petalum appear to have stabilized. Data for other metals, including chromium, mercury, nickel, selenium, and zinc, have been collected since 1994. Over this period, concentrations of these elements have remained relatively constant, aside from seasonal variation that is common to all elements. In 2011, concentrations of Ag and Cu in M. petalum varied seasonally in response to a combination of site-specific metal exposures and annual growth and reproduction, as reported previously. Seasonal patterns for other elements, including Cr, Hg, Ni, Se, and Zn, were generally similar in timing and magnitude as those for Ag and Cu. In 2011, metal concentrations in both sediments and clam tissue were among the lowest concentrations on record. This record suggests that regional-scale factors now largely control sedimentary and bioavailable concentrations of Ag and Cu, as well as other elements of regulatory interest, at the Palo Alto site. Analyses of the benthic community structure of a mudflat in South San Francisco Bay over a 38-year period show that changes in the community have occurred concurrent with reduced concentrations of metals in the sediment and in the tissues of the biosentinel clam, M. petalum, from the same area. Analysis of the M. petalum community

  15. Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases.

    Science.gov (United States)

    Calić, Maja; Bosak, Anita; Kuca, Kamil; Kovarik, Zrinka

    2008-09-25

    Kinetic parameters were evaluated for inhibition of native and reactivation of tabun-inhibited human erythrocyte acetylcholinesterase (AChE, EC 3.1.1.7) and human plasma butyrylcholinesterase (BChE, EC 3.1.1.8) by three bispyridinium para-aldoximes with butane (K074), but-2-ene (K075) or xylene-like linker (K114). Tested aldoximes reversibly inhibited both cholinesterases with the preference for binding to the native AChE. Both cholinesterases showed the highest affinity for K114 (K(i) was 0.01 mM for AChE and 0.06 mM for BChE). The reactivation of tabun-inhibited AChE was efficient by K074 and K075. Their overall reactivation rate constants were around 2000 min(-1)M(-1), which is seven times higher than for the classical bispyridinium para-aldoxime TMB-4. The reactivation of tabun-inhibited AChE assisted by K114 was slow and reached 90% after 20 h. Since the aldoxime binding affinity of tabun-inhibited AChE was similar for all tested aldoximes (and corresponded to their K(i)), the rate of the nucleophilic displacement of the phosphoryl-moiety from the active site serine was the limiting factor for AChE reactivation. On the other hand, none of the aldoximes displayed a significant reactivation of tabun-inhibited BChE. Even after 20 h, the reactivation maximum was 60% for 1 mM K074 and K075, and only 20% for 1 mM K114. However, lower BChE affinities for K074 and K075 compared to AChE suggest that the fast tabun-inhibited AChE reactivation by these compounds would not be obstructed by their interactions with BChE in vivo.

  16. C60 and Sc3N@C80(TMB-PPO derivatives as constituents of singlet oxygen generating, thiol-ene polymer nanocomposites

    Directory of Open Access Journals (Sweden)

    Ashli R. Toles

    2016-07-01

    Full Text Available Numerous functionalization methods have been employed to increase the solubility, and therefore, the processability of fullerenes in composite structures, and of these radical addition reactions continue to be an important methodology. C60 and Sc3N@C80 derivatives were prepared via radical addition of the photodecomposition products from the commercial photoinitiator TMB-PPO, yielding C60(TMB-PPO5 and Sc3N@C80(TMB-PPO3 as preferred soluble derivatives obtained in high yields. Characterization of the mixture of isomers using standard techniques suggests an overall 1PPO:6TMB ratio of addends, reflecting the increased reactivity of the carbon radical. Although, a higher percentage of PPO is observed in the Sc3N@C80(TMB-PPO3 population, perhaps due to reverse electronic requirements of the substrate. Visually dispersed thiol-ene nanocomposites with low extractables were prepared using two monomer compositions (PETMP:TTT and TMPMP:TMPDE with increasing fullerene derivative loading to probe network structure-property relationships. Thermal stability of the derivatives and the resulting networks decreased with increased functionality and at high fullerene loadings, respectively. TMPMP:TMPDE composite networks show well-dispersed derivatives via TEM imaging, and increasing Tg’s with fullerene loading, as expected for the incorporation of a more rigid network component. PETMP:TTT composites show phase separation in TEM, which is supported by the observed Tg’s. Singlet oxygen generation of the derivatives decreases with increased functionality; however, this is compensated for by the tremendous increase in solubility in organic solvents and miscibility with monomers. Most importantly, singlet oxygen generation from the composites increased with fullerene derivative loading, with good photostability of the networks.

  17. Studies directed towards a mechanistic evaluation of inactivation of aromatase by the suicide substrates androsta-1,4-diene-3,17-diones and its 6-ene derivatives aromatase inactivation by the 19-substituted derivatives and their enzymic aromatization.

    Science.gov (United States)

    Numazawa, Mitsuteru; Nagaoka, Masao; Handa, Wakako; Ogawa, Yoko; Matsuoka, Satomi

    2007-01-01

    To gain insight into the mechanistic features for aromatase inactivation by the typical suicide substrates, androsta-1,4-diene-3,17-dione (ADD, 1) and its 6-ene derivative 2, we synthesized 19-substituted (methyl and halogeno) ADD and 1,4,6-triene derivatives 8 and 10 along with 4,6-diene derivatives 9 and tested for their ability to inhibit aromatase in human placental microsomes as well as their ability to serve as a substrate for the enzyme. 19-Methyl-substituted steroids were the most powerful competitive inhibitors of aromatase (K(i): 8.2-40 nM) in each series. Among the 19-substituted inhibitors examined, 19-chloro-ADD and its 6-ene derivatives (7b and 9b) inactivated aromatase in a time-dependent manner in the presence of NADPH in air while the other ones did not. The time-dependent inactivation was blocked by the substrate AD and required NADPH. Only the time-dependent inactivators 7b and 9b in series of 1,4-diene and 1,4,6-triene steroids as well as all of 4,6-diene steroids 9, except for the methyl compound 9a, served as a substrate for aromatase to yield estradiol and/or its 6-ene estradiol with lower conversion rates compared to the corresponding parent steroids 1,4-diene, 1,4,6-triene and 4,6-diene derivatives. The present findings strongly suggest that the aromatase reaction, 19-oxygenation, at least in part, would be involved in the time-dependent inactivation of aromatase by the suicide substrates 1 and 2, where the 19-substitutent would play a critical role in the aromatase reaction probably though steric and electronic reasons.

  18. Aproximación a la situación de salud en tres comunidades Asháninkas ubicadas en las cuencas del río Tambo y Ene, 2006

    OpenAIRE

    Carolina Tarqui-Mamani; Javier Vargas-Herrera; Elisa Terreros-Martínez; Walter Torres

    2009-01-01

    En mayo de 2006 se realizó un estudio transversal en tres comunidades Asháninkas ubicadas en las cuencas de los ríos Tambo y Ene, para describir su situación de salud. Se definió la situación salud sobre la base de cinco indicadores: prevalencia de la desnutrición infantil, enfermedades diarreicas agudas (EDA), infecciones respiratorias agudas (IRA), mortalidad materna y mortalidad infantil. Se interrogó a los padres o madres de familia acerca de defunciones en menores de 1 año, defunciones m...

  19. Kas oleksite nõus koolidirektorina võtma endale karistusõigust, seega õigust õpilasi trahvida? / Ojaveer, Ott; Tannberg, Ene; Kikas, Peeter; Braziulane, Alina; Samm, Toomas; Reinson, Jaan; Asser, Hiie; Kokk, Undel; Serk, Ants; Ahven, Ruth

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad Hugo Treffneri gümnaasiumi direktor Ott Ojaveer, Miina Härma gümnaasiumi direktor Ene Tannberg, Tartu kunstigümnaasiumi direktor Peeter Kikas, Vene lütseumi direktor Alina Braziulane, Mart Reiniku gümnaasiumi direktor Toomas Samm, Descantes'i lütseumi direktor Jaan Reinson, Annelinna gümnaasiumi direktor Hiie Asser, Karlova gümnaasiumi direktor Undel Kokk, Kivilinna gümnaasiumi direktor Ants Serk, Veeriku kooli direktor Ruth Ahven

  20. Synphos modified Pt nanoclusters, their heterogenization by silica sol-gel entrapment, and catalytic activity in hydrogenolysis of bicyclo[2.2.2]oct-7-enes and hydrogenation of ethyl pyruvate

    Energy Technology Data Exchange (ETDEWEB)

    Neatu, F; Parvulescu, V I [Faculty of Chemistry, Department of Chemical Technology and Catalysis, University of Bucharest, B-dul Regina Elisabeta 4-12, Bucharest 030018 (Romania); Kraynov, A [Jacobs University Bremen, Campus Ring 8, D-28759 Bremen (Germany); Kranjc, K; Kocevar, M [Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, SI-1000 Ljubljana (Slovenia); Ratovelomanana-Vidal, V [Laboratoire de Synthese Selective Organique et Produits Naturels, Ecole Nationale Superieure de Chimie de Paris, UMR 7573 CNRS, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05 (France); Richards, R [Department of Chemistry and Geochemistry, Colorado School of Mines, 1500 Illiniois, Golden, CO 80401 (United States)], E-mail: v_parvulescu@chem.unibuc.ro, E-mail: virginie-vidal@enscp.fr, E-mail: rrichard@mines.edu

    2008-06-04

    Platinum (Pt) colloids modified by the chiral ligand synphos were prepared with the goal of obtaining a catalytic nanomaterial and were subsequently embedded in silica to form a heterogeneous catalyst. The systems were characterized by {sup 31}P-NMR, x-ray diffraction, molecular modeling and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTs) measurements. These colloids, both as 'quasi-homogeneous catalysts' (or soluble heterogeneous catalysts) and embedded in silica (heterogeneous catalysts) were employed in the selective hydrogenolysis of highly sterically constrained bicyclo[2.2.2]oct-7-enes and hydrogenation of ethyl pyruvate.

  1. Heat of Mixing and Solution of Hex-1-ene C6H12 + C6H18N3OP Phosphoric tris(dimethylamide) (HMSD1111, LB3772_H)

    Science.gov (United States)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Heat of Mixing and Solution of Hex-1-ene C6H12 + C6H18N3OP Phosphoric tris(dimethylamide) (HMSD1111, LB3772_H)' providing data from direct low-pressure calorimetric measurement of molar excess enthalpy at variable mole fraction and constant temperature.

  2. Preparation of a novel weak cation exchange/hydrophobic interaction chromatography dual-function polymer-based stationary phase for protein separation using "thiol-ene click chemistry".

    Science.gov (United States)

    Yang, Fan; Bai, Quan; Zhao, Kailou; Gao, Dong; Tian, Lei

    2015-02-01

    A novel dual-function mixed-mode stationary phase based on poly(glycidyl methacrylate-co-ethylene dimethacrylate) microspheres was synthesized by thiol-ene click chemistry and characterized by infrared spectroscopy and elemental analysis. The new system displays both hydrophobic interaction chromatography (HIC) character in a high salt concentration mobile phase, and weak cation exchange (WCX) chromatography character in a low salt concentration mobile phase. It can be used to separate proteins in both ion-exchange chromatography (IEC) mode and HIC mode. The resolution and selectivity of the stationary phase were evaluated in both HIC mode and IEC mode using protein standards. In comparison with the conventional WCX and HIC columns, the results were satisfactory and acceptable. Protein mass and bioactivity recoveries of more than 96% can be achieved in both HIC mode and IEC mode using this column. The results indicate that the novel dual-function mixed-mode column in many cases can replace the use of two individual WCX and HIC columns. In addition, the effects on protein separation of different ligand structures in the dual-function stationary phase and the pH of the mobile phase used were also investigated in detail. The results show that electrostatic interaction of the ligand with proteins must match the hydrophobicity of the ligand, which is an important factor to prepare the dual-function stationary phase. On the basis of this dual-function mixed-mode chromatography column, a new two-dimensional liquid chromatography technology with a single column system was also developed in this study, and was used to renature and purify recombinant human interferon-γ from inclusion bodies. The mass recovery, purity, and specific bioactivity obtained for the purified recombinant human interferon-γ were 87.2%, 92.4%, and 2.8 × 10(7) IU/mg, respectively, in IEC mode, and 83.4%, 95.2%, and 4.3 × 10(7) IU/mg, respectively, in HIC mode. The results indicate that the

  3. Zeytinli Ada İskelet Topluluğunun Diş ve Çene Patolojisi Açısından İncelenmesi

    Directory of Open Access Journals (Sweden)

    Saadet BIÇAK

    2015-03-01

    Full Text Available Özet. Zeytinli ada, Balıkesir ili Erdek ilçesi sahiline yaklaşık olarak 250 metre uzaklıkta yer alıp 7900 metrekarelik bir alanı kapsar. Zeytinli ada arkeolojik buluntuları açısından oldukça zengin bir tarihe ve aynı zamanda da Helen-Roma-Bizans ve Osmanlı dönemlerini içeren mozaik bir yapıya sahiptir. Çalışma materyalini, 2007-2011 yılları arasında gerçekleştirilen kazılar sonucunda ortaya çıkarılan 18 kadın, 37 erkek, 11 bebek ve çocuk, 60’ı cinsiyeti bilinmeyen olmak üzere toplam 126 bireye ait çene ve dişler oluşturmaktadır. Bireylere ait 467 diş üzerinde çürük, aşınma, apse, ölüm öncesi diş kaybı (antemortem, hypoplasia, alveol kaybı ve diş taşına bakılarak bunların bireylere ve cinsiyetlere göre dağılımları ortaya konulmaya çalışılmıştır. Abstract. Zeytinli ada, being far away almost 250 meters from the Coast of Erdekli in Balıkesir, takes in the area of 7900 sqm. Zeytinli Ada has a rich history in the view of archeological finds and also has a mosaic structure including the periods of Hellen-Rome- Byzantine and Ottoman. The study materials consist of jaws and teeth belonging to total 126 people ; 18 women, 38 men, 11 infants and  children, 60 unknown  sex  having been  come into existence in the result of excavations between 2007-2011 years.  It is studied to determine the distribution according to the gender and individuals by examining decay, abrasion, abscess, the tooth loss before death (antemortem, hypoplasia, alveolar loss, and dental stone on 467 teeth belonging to individuals.

  4. Palo Monte, um rito Congo em Cuba

    Directory of Open Access Journals (Sweden)

    José da Silva Ribeiro

    2007-01-01

    Full Text Available Juntaram-se em Cuba a partir do século XVI africanos provenientes de toda a costa ocidental africana pertencentes a muitos grupos étnicos. Estes em contacto com as culturas em presença (autóctone, espanhola, portuguesa, africanas desenvolveram diversos sistemas de crença, rituais e práticas mágico-religiosas. No Século XIX o dia de Reis construía o momento mais alto da afirmação da cultura africana em Cuba. Estas manifestações eram acompanhadas da coroação de reis e rainhas Congo, figuras principais da festa e da vida social africana.Africans coming from all West Africa coasts from a large variety of ethnic groups gathered in Cuba since XVIth century. These, in contact with other cultures (native, Spanish, Portuguese, Africans developed some belief systems, rituals and magical-religious practices. On XIXth century the King’s day was the highest moment of affirmation of African culture in Cuba. These experiences were accompanied of king and queen’s crowning, principal figures of African festival and social life.

  5. Advanced Placement Program at Palo Verde College.

    Science.gov (United States)

    Twitchell, Theodore G.

    This study reports the outcome of an initial implementation of a California law permitting mentally gifted high school students to attend a junior college part time. The program procedure is described in terms of (1) selection and enrollment, (2) discipline, (3) books, (4) matters relating to high school graduation, (5) information for parents,…

  6. Kas Ene Ergmast saab president? / Ene Ergma ; interv. Peeter Ernits

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2006-01-01

    Riigikogu aseesimees räägib presidendivalimistel osalemisest, presidendile esitatavatest nõuetest, oma väidetavast kunagisest seotusest Nõukogude eriteenistusega, hariduse tähtsusest Eesti arengus ja Res Publica käekäigust

  7. 2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition.

    Science.gov (United States)

    Tilley, Andrew J; Zanatta, Shannon D; Qin, Cheng Xue; Kim, In-Kyeom; Seok, Young-Mi; Stewart, Alastair; Woodman, Owen L; Williams, Spencer J

    2012-04-01

    Isoflavone consumption correlates with reduced rates of cardiovascular disease. Epidemiological studies and clinical data provide evidence that isoflavone metabolites, such as the isoflavan equol, contribute to these beneficial effects. In this study we developed a new route to isoflavans and isoflavenes via 2-morpholinoisoflavenes derived from a condensation reaction of phenylacetaldehydes, salicylaldehydes and morpholine. We report the synthesis of the isoflavans equol and deoxygenated analogues, and the isoflavenes 7,4'-dihydroxyisoflav-3-ene (phenoxodiol, haganin E) and 7,4'-dihydroxyisoflav-2-ene (isophenoxodiol). Vascular pharmacology studies reveal that all oxygenated isoflavans and isoflavenes can attenuate phenylephrine-induced vasoconstriction, which was unaffected by the estrogen receptor antagonist ICI 182,780. Furthermore, the compounds inhibited U46619 (a thromboxane A(2) analogue) induced vasoconstriction in endothelium-denuded rat aortae, and reduced the formation of GTP RhoA, with the effects being greatest for equol and phenoxodiol. Ligand displacement studies of rat uterine cytosol estrogen receptor revealed the compounds to be generally weak binders. These data are consistent with the vasorelaxation activity of equol and phenoxodiol deriving at least in part by inhibition of the RhoA/Rho-kinase pathway, and along with the limited estrogen receptor affinity supports a role for equol and phenoxodiol as useful agents for maintaining cardiovascular function with limited estrogenic effects. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Estimación del impacto económico de los museos a través de las nuevas tecnologías de la información: el caso del museo Ene.Térmica

    Directory of Open Access Journals (Sweden)

    Vicente COLL-SERRANO

    Full Text Available Cada vez es más necesario poner de relieve el potencial de la cultura como motor del desarrollo económico y su capacidad para generar ingresos y crear empleo. Por este motivo, en este trabajo se evalúa el impacto económico del museo Ene.Térmica sobre el territorio en el que se ubica, Ponferrada (Comunidad de Castilla y León, España. Para lograr este objetivo, la estimación de los distintos tipos de efectos necesarios para determinar el impacto de las actividades económicas vinculas a la existencia de Ene.Térmica se realiza, en base a la metodología de las Tablas Input-Output, mediante la herramienta Impactrimonio, una aplicación implementada sobre una plataforma web. Los resultados obtenidos indican que entre las actividades del museo y los flujos de demanda desplegados por el efecto arrastre de los visitantes se generó, entre los años 2011 y 2012, un incremento de la producción de más de 15 millones de euros, un incremento de las rentas de la población de casi 10 millones de euros y un aumento de la ocupación de 327 empleos.

  9. In-situ functionalized monolithic polysiloxane-polymethacrylate composite materials from polythiol-ene double click reaction in capillary column format for enantioselective nano-high-performance liquid chromatography.

    Science.gov (United States)

    Wolter, Marc; Lämmerhofer, Michael

    2017-05-12

    This work reports on the proof-of-principle of preparation of novel one step in-situ functionalized monolithic polysiloxane-polymethacrylate composite materials in capillary columns for enantioselective nano-HPLC using a thiol-ene click reaction. Quinine carbamate as functional monomer and ethylene dimethacrylate as crosslinker were both used as ene components in a thermally initiated double click-type polymerization reaction with poly(3-mercaptopropyl)methylsiloxane as thiol component in presence of 1-propanol as porogenic solvent. Elemental analysis and on-capillary fluorescence measurement proved the successful incorporation of the functional chiral monomer into the polymer. Scanning electron microscopy images revealed a macroporous polymer morphology which is typical for a nucleation and growth mechanism of pore formation. The individual microglobules appear relatively spherical and smooth indicating a non-porous nature. Nano-HPLC experiments of the chiral monolithic capillary column provided successful enantiomer separation of N-3,5-dinitrobenzoylleucine as test compound in polar organic elution mode clearly documenting the successful implementation of the proposed concept towards new functionalized monolithic composite materials. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Crystal structure of a compact three-dimensional metal-organic framework based on Cs(+) and (4,5-di-cyano-1,2-phenyl-ene)bis-(phospho-nic acid).

    Science.gov (United States)

    Mendes, Ricardo F; Venkatramaiah, Nutalapati; Tomé, João P C; Almeida Paz, Filipe A

    2016-12-01

    A new metal-organic framework compound, poly[[μ7-dihydrogen (4,5-di-cyano-1,2-phenyl-ene)diphospho-nato]-(oxonium)caesium], [Cs(C8H4N2O6P2)(H3O)] n (I), based on Cs(+) and the organic linker 4,5-di-cyano-1,2-phenyl-ene)bis-(phospho-nic acid, (H4cpp), containing two distinct coordinating functional groups, has been prepared by a simple diffusion method and its crystal structure is reported. The coordination polymeric structure is based on a CsO8N2 complex unit comprising a monodentate hydro-nium cation, seven O-atom donors from two phospho-nium groups of the (H2cpp)(2-) ligand, and two N-atom donors from bridging cyano groups. The high level of connectivity from both the metal cation and the organic linker allow the formation of a compact and dense three-dimensional network without any crystallization solvent. Topologically (I) is a seven-connected uninodal network with an overall Schäfli symbol of {4(17).6(4)}. Metal cations form an undulating inorganic layer, which is linked by strong and highly directional O-H⋯O hydrogen-bonding inter-actions. These metallic layers are, in turn, connected by the organic ligands along the [010] direction to form the overall three-dimensional framework structure.

  11. LEADER-tegevusest / Ene Sarapuu

    Index Scriptorium Estoniae

    Sarapuu, Ene

    2009-01-01

    Läänemaa LEADER-tegevusgrupi eesmärk on maakonna kui terviku ühtne areng, et kogu Läänemaa oleks vajalike teenustega kaetud ning ettevõtjad julgeks ning suudaks uute teenuste ja toodetega turule tulla

  12. Parim personaliprojekt 2014 / Ene Olle

    Index Scriptorium Estoniae

    Olle, Ene

    2014-01-01

    Personalijuhtimise ühingu PARE konverentsil "Töötajat väärtustav organisatsioon" pälvis tiitli "Parim personaliprojekt 2013" ettevõtte ISS Eesti erivajadustega inimeste värbamise projekt. Teistest konkursil osalenud projektidest

  13. Messiuudised : Maison & Objet / Ene Jakobi

    Index Scriptorium Estoniae

    Jakobi, Ene

    2008-01-01

    Uusi trende kõige suuremalt disainimessilt Maison & Objet Prantsusmaal - Jean-Charles de Castelbajaci joonistatud toolid, Jean-Christophe Bernardi pleksiklaasist tool ja laud, Joseph Licciardi ja Paul Coheni-Philipp Veenendaali etanoolil põlevad kaminad, Philippe Lebru kellad, Vincenzo Antonuccio vaasid ja Anna Siedlecka ning Radek Achramoviczi täispuhutavad valgustid

  14. Inimlikkus ja erootika / Ene Lamp

    Index Scriptorium Estoniae

    Lamp, Ene

    1998-01-01

    Erootilise motiivi toimimisest eelmise ja praeguse sajandivahetuse kunstis Pärnu Uue Kunsti Muuseumi korraldatud näituste - Gustav Klimti ja Egon Schiele akvarellide ja joonistuste faksiimiletest, Jean Rustini maalidest - põhjal. Erotismi jõudmisest eesti kunsti (Triik, Vabbe, Wiiralt)

  15. Paleoenvironmental significance of aluminum phosphate-sulfate minerals in the upper Cretaceous ooidal ironstones, E-NE Aswan area, southern Egypt

    Science.gov (United States)

    Salama, Walid

    2014-09-01

    Aluminum phosphate-sulfate (APS) minerals are present as small, disseminated crystals in the upper Cretaceous shallow marine ooidal ironstones, E-NE Aswan area, southern Egypt. Their association with the ironstones is considered as a proxy of subaerial weathering and post-diagenetic meteoric water alteration. The mineralogical composition of the ooidal ironstones was investigated by optical and scanning electron microscopes, X-ray diffraction, Fourier transform infrared and Raman spectroscopy. The ooidal ironstones are composed mainly of ooids and groundmass, both of which consist of a mixture of detrital (quartz) and diagenetic (fluorapatite, chamosite and pyrite) mineral assemblages. These mineral assemblages are destabilized under acidic and oxidizing, continental conditions. These conditions resulted from the oxidation of pyrite and probably organic matter under warm and humid, tropical climate followed the Santonian Sea regression and subaerial exposure. These pedogenic conditions promoted corrosion of quartz, dissolution of chamosite and apatite and hydrolysis of feldspars of the nearby exposed granitoids. The released Si, Al and Sr from quartz, chamosite and feldspars; Fe and S from pyrite and P, Ca and light rare earth elements (LREE) from apatite are reprecipitated as hematite, kaolinite, apatite and APS minerals from the pore fluids or along fractures. The paragenetic sequence and textural relationships of this post-diagenetic mineral assemblage indicate that hematite was formed by replacement of chamosite followed by formation of a secondary generation of pore filling chlorapatite and APS minerals and finally the precipitation of kaolinite in the remaining pore spaces. The formation of APS minerals and chlorapatite is simultaneous, but APS minerals are stable at shallow depths under acidic to neutral pH conditions, whereas chlorapatite is stable under alkaline pH conditions. Alkaline conditions were maintained at greater depths when the infiltrated

  16. Anti-inflammatory effect of triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene obtained from Combretum leprosum Mart & Eich in mice.

    Science.gov (United States)

    Longhi-Balbinot, Daniela T; Lanznaster, Débora; Baggio, Cristiane Hatsuko; Silva, Morgana Duarte; Cabrera, Celeste Heiseke; Facundo, Valdir A; Santos, Adair R S

    2012-06-26

    The 3β, 6β, 16β-trihydroxylup-20(29)-ene (TTHL) is a pentacyclic triterpene obtained from a medicinal plant named Combretum leprosum. In folk medicine, this plant is used to treat several diseases associated with inflammation and pain. We previously demonstrated that TTHL presents a significant antinociceptive effect, suggesting the involvement of the glutamatergic system. This study was designed to investigate the effect of TTHL on nociception and vascular permeability induced by acetic acid. We also evaluated the effect of TTHL on carrageenan-induced peritonitis and the levels of cytokines (interleukin 1-β [IL-1β], tumor necrosis factor α [TNF-α] and interleukin 10 [IL-10]) on peritoneal fluid. TTHL was administered orally by intra-gastric gavage (i.g.) 60 min prior to experimentation. Abdominal contractions and vascular permeability were induced by an intraperitoneal (i.p.) injection of acetic acid (0.6%). We also investigated whether TTHL decreases carrageenan-induced peritonitis (750 μg/cavity) by measuring leukocyte migration and vascular permeability. In addition, we evaluated the effects of TTHL on TNF-α, IL-1β and IL-10 release induced by carrageenan on peritoneal fluid. The levels of these cytokines were measured by ELISA. TTHL (0.01-10 mg/kg) administered by intra-gastric (i.g.) gavage inhibited (69±3%) acetic acid-induced abdominal constrictions, with an ID₅₀ of 0.15 (0.03-0.8) mg/kg. TTHL (10mg/kg) also reduced the leukocyte infiltration induced by acetic acid, with an inhibition of 59±9 but had no effect on abdominal vascular permeability. In addition, indomethacin (10 mg/kg, i.p.) reduced the nociceptive behavior (92±1%), total leukocyte migration (29±3%) and capillary permeability (71±3%) induced by acetic acid. While the glucocorticoid dexamethasone (2 mg/kg, s.c.) reduced partially but significantly the nociception (31±1%), besides to promote a marked reduction on total leukocyte migration (60±2%) to the peritoneal cavity

  17. Transformations of the molecular complex of hydroiodide of 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene and 5,5‧-dibromo-2,2‧-biphenol between crystal and solutions

    Science.gov (United States)

    Wojciechowski, Grzegorz; Ratajczak-Sitarz, Małgorzata; Katrusiak, Andrzej; Brzezinski, Bogumil

    2005-05-01

    A complex of 5,5'-dibromo-2,2'-biphenol with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene hydroiodide has been studied by X-ray diffraction, FT-IR, and 1HNMR spectroscopy. In the crystal structure, the iodide anion is hydrogen-bonded to the MTBDH + cation and to two hydroxyl groups of two 5,5'-dibromo-2,2'-biphenol molecules. In chloroform and acetonitrile the structure of the complex assumes a new structure due to almost complete dissociation of the protonated MTBD molecule. In chloroform the MTBDH + cation is hydrogen bonded to 5,5'-dibromo-2,2'-biphenol whereas in acetonitrile it is free and solvated by the solvent. In both cases the 5,5'-dibromo-2,2'-biphenol molecule is hydrogen bonded to the iodide anion. In chloroform the iodide ion interacts strongly with the solvent.

  18. Synthesis and Evaluation of in Vitro Biological Activity of 4-Substituted Arylpiperazine Derivatives of 1,7,8,9-Tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

    Directory of Open Access Journals (Sweden)

    David Collu

    2009-12-01

    Full Text Available A series of twenty arylpiperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared. These derivatives were tested in vitro with the aim of identifying novel lead compounds active against emergent and re-emergent human and cattle infectious diseases (AIDS, hepatitis B and C, tuberculosis, bovine viral diarrhea. In particular, these compounds were evaluated in vitro against representatives of different virus classes, such as a HIV-1 (Retrovirus, a HBV (Hepadnavirus and the single-stranded RNA+ viruses Yellow fever virus (YFV and Bovine viral diarrhea virus (BVDV, both belonging to the Flaviridae. Compounds 2c, 2g and 3d showed a modest activity against CVB-2. The molecular structures of the starting imide 1 and one of propyl-piperazine derivatives, 3b, have been determined by an X-ray crystallography study.

  19. Urve Palo : "Tshitaja Delfi, hotshetsja povessitsja..." / Urve Palo ; interv. Jana Litvinova

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2007-01-01

    Rahvastikuminister vastab küsimustele, mis puudutavad uut integratsiooniprogrammi, eesti keele valdamist, keeleoskust, vähemusrahvustega ühise inforuumi loomist, kodakondsuse saamist, eesti keele ja rahvuse püsimist

  20. The Bridges SOI Model School Program at Palo Verde School, Palo Verde, Arizona.

    Science.gov (United States)

    Stock, William A.; DiSalvo, Pamela M.

    The Bridges SOI Model School Program is an educational service based upon the SOI (Structure of Intellect) Model School curriculum. For the middle seven months of the academic year, all students in the program complete brief daily exercises that develop specific cognitive skills delineated in the SOI model. Additionally, intensive individual…

  1. Rhodium-catalyzed [5 + 2 + 1] cycloaddition of ene-vinylcyclopropanes and CO: reaction design, development, application in natural product synthesis, and inspiration for developing new reactions for synthesis of eight-membered carbocycles.

    Science.gov (United States)

    Wang, Yi; Yu, Zhi-Xiang

    2015-08-18

    Practical syntheses of natural products and their analogues with eight-membered carbocyclic skeletons are important for medicinal and biological investigations. However, methods and strategies to construct the eight-membered carbocycles are limited. Therefore, developing new methods to synthesize the eight-membered carbocycles is highly desired. In this Account, we describe our development of three rhodium-catalyzed cycloadditions for the construction of the eight-membered carbocycles, which have great potential in addressing the challenges in the synthesis of medium-sized ring systems. The first reaction described in this Account is our computationally designed rhodium-catalyzed two-component [5 + 2 + 1] cycloaddition of ene-vinylcyclopropanes (ene-VCPs) and CO for the diastereoselective construction of bi- and tricyclic cyclooctenones. The design of this reaction is based on the hypothesis that the C(sp(3))-C(sp(3)) reductive elimination of the eight-membered rhodacycle intermediate generated from the rhodium-catalyzed cyclopropane cleavage and alkene insertion, giving Wender's [5 + 2] cycloadduct, is not easy. Under CO atmosphere, CO insertion may occur rapidly, converting the eight-membered rhodacycle into a nine-membered rhodacycle, which then undergoes an easy C(sp(2))-C(sp(3)) reductive elimination process and furnishes the [5 + 2 + 1] product. This hypothesis was supported by our preliminary DFT studies and also served as inspiration for the development of two [7 + 1] cycloadditions: the [7 + 1] cycloaddition of buta-1,3-dienylcyclopropanes (BDCPs) and CO for the construction of cyclooctadienones, and the benzo/[7 + 1] cycloaddition of cyclopropyl-benzocyclobutenes (CP-BCBs) and CO to synthesize the benzocyclooctenones. The efficiency of these rhodium-catalyzed cycloadditions can be revealed by the application in natural product synthesis. Two eight-membered ring-containing natural products, (±)-asterisca-3(15),6-diene and (+)-asteriscanolide, have been

  2. Three closely related (2E,2'E)-3,3'-(1,4-phenyl-ene)bis-[1-(meth-oxy-phen-yl)prop-2-en-1-ones]: supra-molecular assemblies in one dimension mediated by hydrogen bonding and C-H⋯π inter-actions.

    Science.gov (United States)

    Sim, Aijia; Chidan Kumar, C S; Kwong, Huey Chong; Then, Li Yee; Win, Yip-Foo; Quah, Ching Kheng; Naveen, S; Chandraju, S; Lokanath, N K; Warad, Ismail

    2017-06-01

    In the title compounds, (2E,2'E)-3,3'-(1,4-phenyl-ene)bis-[1-(2-meth-oxy-phen-yl)prop-2-en-1-one], C26H22O4 (I), (2E,2'E)-3,3'-(1,4-phenyl-ene)bis-[1-(3-meth-oxy-phen-yl)prop-2-en-1-one], C26H22O4 (II) and (2E,2'E)-3,3'-(1,4-phenyl-ene)bis-[1-(3,4-di-meth-oxy-phen-yl)prop-2-en-1-one], C28H26O6 (III), the asymmetric unit consists of a half-mol-ecule, completed by crystallographic inversion symmetry. The dihedral angles between the central and terminal benzene rings are 56.98 (8), 7.74 (7) and 7.73 (7)° for (I), (II) and (III), respectively. In the crystal of (I), mol-ecules are linked by pairs of C-H⋯π inter-actions into chains running parallel to [101]. The packing for (II) and (III), features inversion dimers linked by pairs of C-H⋯O hydrogen bonds, forming R22(16) and R22(14) ring motifs, respectively, as parts of [201] and [101] chains, respectively.

  3. Cycloartan-24-ene-1α,2α,3β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells.

    Science.gov (United States)

    Gao, Wenyan; Su, Xiaojie; Dong, Xiaoyan; Chen, Yingli; Zhou, Chunlan; Xin, Ping; Yu, Chunhao; Wei, Taiming

    2015-03-01

    Plant-derived antitumor drugs are currently used in chemotherapy. Cycloartane triterpenoids have shown a cytotoxic effect on human prostate cancer cells. The aim of the present study was to isolate a cycloartane triterpenoid from Commiphora myrrha and evaluate its anticancer potential. Cycloartan-24-ene-1α,2α,3β-triol (MY-1) was isolated from Commiphora myrrha, and its structure was determined through 1H and 13C nuclear magnetic resonance spectroscopy. The cytotoxic and apoptotic effects of MY-1 on human prostatic cancer PC-3 cells were estimated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometric analysis and terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) staining assay, and the expression of apoptotic-related proteins were evaluated by western blotting. MY-1 showed cytotoxic activity on PC-3 cells in a concentration-dependent manner with an IC50 value of 9.6 µM at 24 h. MY-1 induced cell cycle arrest and apoptosis. Western blot analysis revealed that MY-1 regulated the expression levels of B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), p53 and caspase-3 in the PC-3 cells. These findings indicate that MY-1 exerts significantly pro-apoptotic activity against human hormone-independent prostatic cancer and support MY-1 as a potential anticancer drug.

  4. Structural, spectroscopic and theoretical studies of the 2:2 complex of 5,5‧-dibromo-2,2‧-biphenol with 1,5,7-triazabicyclo[4.4.0]dec-5-ene

    Science.gov (United States)

    Wojciechowski, G.; Brzezinski, B.; Naumov, P.; Chantrapromma, S.; Ibrahim, A. R.; Fun, H.-K.; Ng, S. W.

    2001-12-01

    In the crystal of the 2:2 complex of 1,5,7-triazabicyclo[4.4.0]dec-5-ene with 5,5‧-dibromo-2,2‧-biphenol a cooperative inter-intra-molecular hydrogen-bonded system is formed. The intermolecular hydrogen bonds are relatively long [2.708(6) and 2.895(7)] and do not show large proton polarizability. The intramolecular OHO- hydrogen bond is relatively short [2.489(6)]. The structure of the complex is very well reflected in its FT-IR spectrum in the solid. On the basis of the FT-IR and 1H NMR studies of the complex in chloroform and in acetonitrile a structure different than in the solid is proposed. DFT structures of both isolated ions in their ground electronic states at the B3LYP/6-31++G(d,p) level are employed to follow the effects of the hydrogen bonding on the intrinsic ionic structures.

  5. Crystal and molecular structure of a complex formed between the hydrochloride of 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene and 5,5‧-dibromo-2,2‧-biphenol

    Science.gov (United States)

    Bartoszak-Adamska, E.; Wojciechowski, G.; Jaskólski, M.; Brzezinski, B.

    2001-09-01

    A complex of 5,5‧-dibromo-2,2‧-biphenol with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD) hydrochloride has been studied using X-ray diffraction, FT-IR, and 1H NMR spectroscopy. The compound crystallises in the space group P21/c with a=9.738(2), b=12.100(2), c=18.347(4) Å,β=92.62(3)° (at 100 K), and Z=4. In the crystal structure, the MTBDH+ cation, a chloride anion, and one molecule of 5,5‧-dibromo-2,2‧-biphenol are present. In the solid state the Cl- anion is an acceptor in N+-H⋯Cl-, O-H⋯Cl- and C-H⋯Cl- intermolecular hydrogen bonds. In chloroform the structure of the complex is comparable with that in the solid, whereas in acetonitryle the complex assumes a new structure owing to the almost complete dissociation of the protonated MTBD molecule. The 5,5‧-dibromo-2,2‧-biphenol molecule is hydrogen-bonded with the chloride anion. Within this complex the OH⋯OH hydrogen bond shows very large proton polarisability indicated by the continuous absorption in the FTIR spectrum.

  6. Molecular structure of a complex formed between hydrobromide of 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene and 5,5'-dibromo-2,2'-biphenol in crystal and solutions

    Science.gov (United States)

    Wojciechowski, Grzegorz; Ratajczak-Sitarz, Małgorzata; Katrusiak, Andrzej; Brzezinski, Bogumil

    2002-08-01

    A complex of 5,5'-dibromo-2,2'-biphenol with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene hydrobromide has been studied using X-ray diffraction, FT-IR, and 1H NMR spectroscopy. In the crystal structure, a bromide anion is hydrogen-bonded with MTBDH + cation and two hydroxyl groups of two 5,5'-dibromo-2,2'-biphenol molecules. In the solid state, the Br - anion is an acceptor in N +-H⋯Br -, and two O-H⋯Br - intermolecular hydrogen bonds. In chloroform and acetonitrile, the structure of the complex assumes a new structure due to almost complete dissociation of protonated MTBD molecule. In chloroform, the MTBDH + cation is hydrogen-bonded with 5,5'-dibromo-2,2'-biphenol whereas in acetonitrile it is free and solvated by the solvent. In both cases, the 5,5'-dibromo-2,2'-biphenol molecule is hydrogen-bonded to the bromide anion.

  7. Cooperative hydrogen-bonded chain in molecular ionic complex of 5,5'-dibromo-2,2'-biphenol with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene hydrofluoride

    Science.gov (United States)

    Wojciechowski, Grzegorz; Ratajczak-Sitarz, Małgorzata; Katrusiak, Andrzej; Brzezinski, Bogumil

    2002-08-01

    A complex of 5,5'-dibromo-2,2'-biphenol (DBBPh) with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD) hydrofluoride has been studied using X-ray diffraction, FT-IR, and 1H NMR spectroscopy. The formula unit of the crystal structure consists of a MTBDH + cation, a fluoride anion, and one neutral molecule of 5,5'-dibromo-2,2'-biphenol. In the solid state the F - anion is an acceptor in two very short O-H⋯F - intermolecular hydrogen bonds of 2.487 and 2.390 Å involving the hydroxyl groups. One oxygen atom of these groups forms also an N +-H⋯O intermolecular hydrogen bond of 2.775 Å with the MTBDH + cation. In chloroform and acetonitrile, the structures of the complexes are comparable with those studied previously for 5,5'-dibromo-2,2'-biphenol with MTBD, because the hydrogen fluoride goes into the gas phase during the solution process.

  8. Antimicrobial Effect of the Triterpene 3β,6β,16β-Trihydroxylup-20(29-ene on Planktonic Cells and Biofilms from Gram Positive and Gram Negative Bacteria

    Directory of Open Access Journals (Sweden)

    Francisco Flávio Vasconcelos Evaristo

    2014-01-01

    Full Text Available This study evaluated the antimicrobial effect of 3β,6β,16β-trihydroxylup-20(29-ene (CLF1, a triterpene isolated from Combretum leprosum Mart., in inhibiting the planktonic growth and biofilms of Gram positive bacteria Streptococcus mutans and S. mitis. The antimicrobial activity was assessed by determining the minimum inhibitory concentration (MIC and minimum bactericidal concentration (MBC. The antibiofilm potential was determined by quantifying total biomass and enumerating biofilm-entrapped viable bacteria. In addition, the acute toxicity of CLF1 on Artemia sp. nauplii was also determined. The results showed that CLF1 was able in inhibiting the growth of S. mutans and S. mitis with MIC and MBC of 7.8 μg/mL and 15.6 μg/mL, respectively. CLF1 was highly effective on biofilms of both bacteria. Only 7.8 μg/mL CLF1 was enough to inhibit by 97% and 90% biomass production of S. mutans and S. mitis, respectively. On the other hand, such effects were not evident on Gram negative Pseudomonas aeruginosa and Klebsiella oxytoca. The toxicity tests showed that the LC50 of CLF1 was 98.19 μg/mL. Therefore, CLF1 isolated from C. leprosum may constitute an important natural agent for the development of new therapies for caries and other infectious diseases caused by S. mutans and S. mitis.

  9. Molecular structure, vibrational spectroscopic, first order hyperpolarizability and HOMO-LUMO studies of 7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.

    Science.gov (United States)

    Ramalingam, M; Sethuraman, V; Sundaraganesan, N

    2011-02-01

    The FT-IR and FT-Raman spectra of 7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (7AVCA) were recorded in the region 4000-400 cm(-1) and 3500-10 cm(-1), respectively. Quantum chemical calculations of energies, geometrical structure and vibrational wavenumbers were carried out by ab initio HF and density functional theoretical methods invoking 6-311G(d,p) basis set. The differences between the observed and scaled wavenumber values of most of the fundamentals are very small. The electric dipole moment (μ) and the first order hyperpolarizability (β0) values have been computed quantum mechanically. The calculated results show that 7AVCA may have microscopic nonlinear optical (NLO) behavior with non-zero values. A detailed interpretation of the FT-IR and FT-Raman spectra of 7AVCA is reported. The theoretical IR and Raman spectra of 7AVCA have also been constructed. The calculated HOMO and LUMO energies show that the charge transfer occurs within the molecule. Copyright © 2010 Elsevier B.V. All rights reserved.

  10. Zinc(II PVC-based membrane sensor based on 5,6-benzo-4,7,13,16,21,24- hexaoxa-1,10-diazabicyclo[8,8,8]hexacos-5-ene

    Directory of Open Access Journals (Sweden)

    Zamani Hassan Ali

    2006-01-01

    Full Text Available The 5,6-benzo-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8,8,8]hexacos-5-ene (BHDE was used as an excellent ionophore in construction of a Zn(II PVC-based membrane sensor. The best performance was obtained with a membrane composition of 30% poly(vinyl chloride, 64.5% nitrobenzen (NB, 2.5% BHDE and 3% sodium tetraphenylborate (NaTPB. This sensor shows very good selectivity and sensitivity towards zinc ion over a wide variety of cations, including alkali, alkaline earth, transition and heavy metal ions. The sensor revealed a great enhancement in selectivity coefficients for zinc ions, in comparison to the previously reported zinc sensors. The proposed sensor exhibits a Nernstian behavior (with slope of 29.1 ? 0.4 mV per decade over a wide concentration range (1.0 10-6-1.0 10-1 mol L-1 with a detection limit of 6.3 x10-7 mol L-1 (41.2 ng mL-1. It shows relatively fast response time, in the whole concentration range (< 10s, and can be used for at least 10 weeks in a pH range of 2.8-7.3. The proposed sensor was successfully used in direct determination of zinc ions in wastewater of industrial zinc electroplating companies, and also as an indicator electrode in titration with EDTA.

  11. New optically active and thermally stable poly(amide-imide)s containing N,N'-(Bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic)-bis-L-alanine and aromatic diamines: synthesis and characterization

    Energy Technology Data Exchange (ETDEWEB)

    Faghihi, Khalil; Absalar, Morteza; Hajibeygi, Mohsen [Arak University (Iran, Islamic Republic of). Faculty of Science. Organic Polymer Chemistry Research Lab.

    2009-07-01

    Five new optically active poly(amide-imide)s (PAIs) 6a-e were prepared by direct polycondensation reaction of the newly synthesized N,N'-(bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetra carboxylic)-bis-L-alanine 4 with various aromatic diamines 5a-e using polar aprotic solvents such as N-methyl-2-pyrrolidone (NMP). In this technique triphenyl phosphite (TPP) and pyridine were used as condensing agents to form poly(amide-imide)s through the N-phosphonium salts of pyridine. All of the polymers were obtained in quantitative yields with inherent viscosities between 0.29-0.46 dL g{sup -1} and were highly soluble in polar aprotic solvents such as N,N-dimethyl acetamide (DMAc), N,N-dimethyl formamide (DMF), dimethyl sulfoxide (DMSO), N-methyl- 2-pyrrolidone (NMP) and solvents such as sulfuric acid. They were fully characterized by means of {sup 1}H NMR, FTIR spectroscopy, elemental analyses, inherent viscosity, solubility test, specific rotation and thermal properties of these polymers were investigated using thermogravimetric analysis techniques (TGA and DTG). (author)

  12. Facile one-pot synthesis of a aptamer-based organic-silica hybrid monolithic capillary column by "thiol-ene" click chemistry for detection of enantiomers of chemotherapeutic anthracyclines.

    Science.gov (United States)

    Jiang, Han-Peng; Zhu, Jiu-Xia; Peng, Chunyan; Gao, Jiajia; Zheng, Fang; Xiao, Yu-Xiu; Feng, Yu-Qi; Yuan, Bi-Feng

    2014-10-07

    In the current study, we developed a facile strategy for the one-pot synthesis of an aptamer-based organic-silica hybrid monolithic capillary column. A 5'-SH-modified aptamer, specifically targeting doxorubicin, was covalently modified in the hybrid silica monolithic column by a sol-gel method combined with "thiol-ene" click reaction. The prepared monolithic column had good stability and permeability, large specific surface, and showed excellent selectivity towards chemotherapeutic anthracyclines of doxorubicin and epirubicin. In addition, the enantiomers of doxorubicin and epirubicin can be easily separated by aptamer-based affinity monolithic capillary liquid chromatography. Furthermore, doxorubicin and epirubicin spiked in serum and urine were also successfully determined, which suggested that the complex biological matrix had a negligible effect on the detection of doxorubicin and epirubicin. Finally, we quantified the concentration of epirubicin in the serum of breast cancer patients treated with epirubicin by intravenous injection. The developed analytical method is cost-effective and rapid, and biological samples can be directly analyzed without any tedious sample pretreatment, which is extremely useful for monitoring medicines in serum and urine for pharmacokinetic studies.

  13. Kohustus kannatada, et näha ja mõista. Ene Mihkelsoni ja Ingeborg Bachmanni kirjanikunägemus. The Writer’s Duty to Suffer in Order to See and Understand: The Literary Vision of Ene Mihkelson and Ingeborg Bachmann

    Directory of Open Access Journals (Sweden)

    Aija Sakova

    2012-04-01

    Full Text Available In an interview from 1971 the Austrian poet and author Ingeborg Bachmann (b 1923 said that there are phenomena that science and scientific language cannot explain. According to her these are the phenomena that belong to the realm of writers and literature. In the same year Ene Mihkelson (b 1946, who had not yet published a single book of poetry or a novel because of censorship, pondered on the role of the author within society: “The author digs under the surface and the author’s responsibility to society lies in his/her persistence, in his/her duty to suffer, to endure stress, which the people in the midst of their busy, daily lives are unable to fully grasp.” Responsibility to society and the duty to suffer and explore the deepest layers below the surface are common to both Mihkelson and Bachmann. Both writers were born and grew up in the shadow of war, violence and totalitarianism. Mihkelson was brought up in a guerrilla family in Soviet Estonia; Bachmann spent her childhood years growing up in the Nationalist-Socialist Austria and in her youth she witnessed the Second World War and its catastrophic consequences. So both of them understand that as writers they cannot overlook the events that they had, either directly or indirectly, witnessed. In an interview from 2009 Mihkelson said that the fact that she remained alive while many did not, that she was not deported to Siberia although it could have happened, has obligated her to write and reflect on what had happened. No consensus has been reached in Europe to condemn Communism as a crime against humanity, but for Estonians Communism and the 50 years of Soviet regime signify a lengthy experience of a totalitarian regime and, in spite of a possible opposition from German-speaking cultures, Communism very often equals Nazism in Estonia. According to Mihkelson, in order to understand and reflect this experience it is not sufficient to rely only on the archives, biographies and books of

  14. The roles of pregn-5-ene-3β,20α-diol and 20α-hydroxy steroid dehydrogenase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat

    Science.gov (United States)

    Kuhn, N. J.; Briley, M. S.

    1970-01-01

    1. The activity of 20α-hydroxy steroid dehydrogenase in rat ovarian corpora lutea increased at least 50-fold between 2 days before and 2 days after parturition, and then fell gradually during lactation. The activity of 3β-hydroxy Δ5-steroid dehydrogenase decreased by 50% at parturition but remained constant at other times. 2. The 20α-hydroxypregn-4-en-3-one/progesterone concentration ratio in the ovary fell tenfold between 1 day before and 1 day after parturition, in contrast with the increase of the ratio for these steroids in plasma. 3. Pregnenolone was metabolized in intact cells or cell-free systems either to pregn-5-ene-3β,20α-diol and then to 20α-hydroxypregn-4-en-3-one by 20α-hydroxy steroid dehydrogenase and 3β-hydroxy Δ5-steroid dehydrogenase respectively, or directly to progesterone by the latter enzyme. The relative activities of these pathways appeared to reflect the relative amounts of the two enzymes and the concentrations of their respective coenzymes NADPH and NAD+. 4. From these and other observations it was concluded that the cessation of progesterone secretion, which precedes parturition and lactogenesis at the end of pregnancy, is partly due to the redirected metabolism of pregnenolone away from progesterone and towards 20α-hydroxypregn-4-en-3-one as the secreted end product. This is primarily the consequence of the sharp increase in the activity of 20α-hydroxy steroid dehydrogenase. This mechanism is super-imposed on the already declining rate of net Δ4-steroid release by the ovary. 5. A relationship of these pathways to subcellular compartments of luteal cells is proposed. PMID:4392955

  15. Situación de riesgo y salud de los adolescentes en el valle de los ríos Apurímac, Ene y Mantaro en Perú

    Directory of Open Access Journals (Sweden)

    Fabiola Yeckting Vilela

    Full Text Available Se presenta el diagnóstico de las condiciones de vida de los adolescentes varones y mujeres en la zona del valle de los ríos Apurímac, Ene y Mantaro (VRAEM, quienes atraviesan situaciones de riesgo y vulnerabilidad social y sexual debido a los altos niveles de producción de la hoja de coca y el contexto del narcotráfico, que crean la ilusión del rápido ascenso social. A partir de ello, es necesario preguntarse ¿cuáles son las condiciones de vida y situaciones de riesgo de los adolescentes en el VRAEM? y ¿cuáles son las alternativas para una mejora de su situación desde el acceso a la educación y los programas de atención de su salud? Esta situación de riesgo es el resultado de las relaciones desiguales de género, violencia sexual, deserción escolar, embarazo adolescente, consumo de alcohol y drogas, así como de la falta de oportunidades como consecuencia de la participación en la economía de la coca y el narcotráfico entre los adolescentes en el VRAEM. Finalmente, se presentan los resultados de la atención de profesionales de los centros de salud para favorecer la consejería en salud sexual y reproductiva y el acceso a los servicios de salud del Programa Vida Adolescente, como oportunidad de vincular los contenidos del currículo de educación y las metas de cumplimiento de este sector, visibilizando la necesidad de un enfoque de interculturalidad e igualdad de género en el acceso a la salud y la educación de los adolescentes.

  16. 7-{[2-(4-Hydroxyphenylmethylidene]amino}-1,3-thiazol-4-yl-2-(methoxyiminoacetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-ylsulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

    Directory of Open Access Journals (Sweden)

    Ghulam Fareed

    2012-05-01

    Full Text Available Novel 7-{[2-(4-hydroxyphenylmethylidene]amino}-1,3-thiazol-4-yl-2-(methoxyiminoacetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-ylsulfanyl]methyl}-8-oxo-5-thia-1azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid was prepared by condensation of ceftriaxone disodium (1 with 4-hydroxybenzaldehyde (2 in ethanol under reflux conditions for 3–4 h. The structure of synthesized compound was elucidated using LCMS, 1H-NMR, and CHN techniques.

  17. Aproximación a la situación de salud en tres comunidades Asháninkas ubicadas en las cuencas del río Tambo y Ene, 2006

    Directory of Open Access Journals (Sweden)

    Carolina Tarqui-Mamani

    2009-01-01

    Full Text Available En mayo de 2006 se realizó un estudio transversal en tres comunidades Asháninkas ubicadas en las cuencas de los ríos Tambo y Ene, para describir su situación de salud. Se definió la situación salud sobre la base de cinco indicadores: prevalencia de la desnutrición infantil, enfermedades diarreicas agudas (EDA, infecciones respiratorias agudas (IRA, mortalidad materna y mortalidad infantil. Se interrogó a los padres o madres de familia acerca de defunciones en menores de 1 año, defunciones maternas, casos de EDA e IRA. Se evaluó el estado nutricional mediante la medición del peso y la talla en niños de 0 a 6 años y se observó el estado de protección vacunal en los carnés de vacunación. Se realizó 53 entrevistas a los padres y se evaluó a 83 niños en las comunidades de Samaniato, Tziquireni y Mayapo. No se reportó muertes maternas ni infantiles. La desnutrición global alcanzó 43,3% y fluctúa entre 53 a 57% entre los 12 y los 47 meses y aumenta a 58,8% después de los 48 meses. La desnutrición crónica alcanzó al 78,3% de niños evaluados. Los padres reportaron que 53,1% de los niños presentaron un episodio de EDA y 57% de IRA. 98,9% de los niños mayores de un año estuvieron protegidos. Los resultados encontrados permiten una aproximación a la situación de salud en las comunidades Asháninkas, lo cual debe favorecer el diseño de programas de intervención focalizados o acciones de ayuda nutricional dirigidas a los niños de dicha comunidad.

  18. Synthesis, biological evaluation, and molecular docking studies of benzyl, alkyl and glycosyl [2-(arylamino)-4,4-dimethyl-6-oxo-cyclohex-1-ene]carbodithioates, as potential immunomodulatory and immunosuppressive agents.

    Science.gov (United States)

    El Ashry, El Sayed H; Amer, Mohammad R; Abdalla, Omer M; Aly, Aly A; Soomro, Samreen; Jabeen, Almas; Halim, Sobia Ahsan; Ahmed Mesaik, M; Ul-Haq, Zaheer

    2012-05-01

    The immunomodulating properties of functionalized [2-(arylamino)-4,4-dimethyl-6-oxo-cyclohex-1-ene] carbodithioates and 6,6-dimethyl-4-(2-(propan-2-ylidene)hydrazinyl)-6,7-dihydro-2H-indazole-3(5H)-thione compounds have been investigated. Four of them, 13, 18, 19 and 20 inhibited PBMC proliferation induced by phytohemagglutinin (PHA) in a dose dependent manner with an IC(50) of ≤ 20 μM. The Th-1 cytokine, interleukin-2 (IL-2) in PHA/PMA-stimulated peripheral blood mononuclear cells (PBMCs) is significantly inhibited by 13, 19 and 20 with an IC(50) of 8.4 ± 0.4, 5.34 ± 0.15 and 4.9 ± 0.7 μM, respectively. They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1β and TNF-α production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1β and by 83.8%, 48.2% and 58.7% for TNF-α, respectively. Only 20 showed significant suppressive activity against the phagocyte oxidative burst in a dose dependent manner, with an IC(50) of 23.8 μM. LPS-induced nitrites in mouse macrophages were found to be inhibited by compounds 6, 8, 13-15 and 19 with an IC(50), which range between 7.7 and 63 μM. The cytotoxicity for the active compounds was also studied on Rat Wistar Hepatocyte cell line, CC1 and the Mouse Fibroblast cell line 3T3 NIH in the presence of compounds using a standard MTT assay. Furthermore, structural-activity relationship using automated docking software revealed that active compounds 7, 13 and 19, adapted the same binding mode, however the most active compound 20 is found deeply inserted within the ligand binding site of IL-2, as multiple hydrophobic and hydrophilic key interactions stabilize the compound inside the binding site, thus contributing higher activity. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. Vaesusriski muutused Eestis / Ene-Margit Tiit

    Index Scriptorium Estoniae

    Tiit, Ene-Margit, 1934-

    2006-01-01

    Seoses Eesti majanduse kiire arenguga tellis sotsiaalministeerium 2005. aastal uue tarbimiskaalude hinnangu, mille aluseks olid leibkonna eelarvehinnangu andmed aastaist 2000-2004 ning hinnati erineva struktuuriga leibkondade tarbimiskulutusi. Diagrammid. Graafikud

  20. Maia Laul / Maia Laul ; interv. Ene Ammer

    Index Scriptorium Estoniae

    Laul, Maia, 1921-2009

    1998-01-01

    Maia Laul eriala omandamisest, õppejõududest. Lõpetas 1949. a. Tallinna Riikliku Tarbekunsti Instituudi. Alar Kotli käealusena "Estonia" teatri taastamisprojekti juures. Peeter Tarvase ja August Volbergiga ENSV paviljponi kujundamas Moskvas VDNHs. Töötamisest ARSis. Sisearhitektuur ja monumentaalkunst (koostöö Eva Jänesega). Esinemistest näitustel "Ruum ja vorm". Ühiskondlike hoonete sisekujundustest. Vanaturu apteek (klaasigraafika Tiit Jürna)

  1. Modernne kastmaja Nõmmel / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    1999-01-01

    Projekteerija: arhitektuuribüroo Mark & Tamm. Konstruktiivne osa: inseneribüroo Randväli Karema. Arhitektid Ülar Mark, Kalle Komissarov. Kahekorruseline maja Vabaduse pst. ääres on mahutatud puude vahele kitsale alale. Kommenteerib Ü. Mark.

  2. Szentendre koolkond / Ene Asu-Õunas

    Index Scriptorium Estoniae

    Asu-Õunas, Ene, 1943-

    2005-01-01

    Näitus "Szentendre kunstnikekoloonia 75" Tartu Kunstimajas. 1928. a. asutatud koloonia taastati 1997. astal. 12 kunstnikku saavad 1-3 aasta vältel kasutada külalisateljeed. Szentendre on tänaseks Euroopa kunstnike kolooniate võrgu liige

  3. Seadusemuudatused, mis teevad elu paremaks / Ene Kaups

    Index Scriptorium Estoniae

    Kaups, Ene, 1963-

    2008-01-01

    2008. aastal jõustuvatest seadusemuudatustest. Ilmunud ka Koit 7. veeb. 2008, lk. 6 ; Lääne Elu 7. veeb. 2008, lk. 2 ; Hiiu Leht 8. veeb. 2008, lk. 2 ; Järva Teataja 9. veeb. 2008, lk. 2 ; Türi Rahvaleht 8. veeb. 2008, lk. 4, pealkiri kujul: Seadusemuudatustest ; Meie Maa 15. veeb. 2008, lk. 2 ; Sakala 15. veeb. 2008, lk. 2, pealkiri kujul: Käesolev aasta toob hulga olulisi muudatusi ; Sõnumitooja 27. veeb. 2008, lk. 2 ; Valgamaalane 26. veeb. 2008, lk. 2

  4. Mida lugeja raamatukogult tegelikult ootab / Ene Riet

    Index Scriptorium Estoniae

    Riet, Ene, 1954-

    2011-01-01

    4. teadus- ja erialaraamatukogude päev toimus 21. oktoobril 2011 Eesti Muusika- ja Teatriakadeemias. Teadusraamatukogu aasta teo auhinna pälvis Urmas Sinisalu tulemusliku ja innovaatilise töö eest raamatukogude infosüsteemi ESTER arendamisel. Erialaraamatukogu aasta teo auhinna sai TÜ ajakirjanduse ja kommunikatsiooni instituudi raamatukoguhoidja Maio Vaniko raamatukogundust arendava tegevuse eest

  5. Riik arhitektuuritellijana / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2010-01-01

    Näidete varal Riigi Kinnisvara AS-i korraldatud projekteerimise hangetest, mil välja valiti odavaim pakkumine. Valminud Rakvere politseihoonest ning Jõgeva kohtu- ja politseihoonest. Mudelprojekteerimise (BIM) nõudest. Riigihankest kui salastatud protsessist. Sunnist loobuda autoriõigusest. Riigihankega ühendatud arhitektuurikonkursist

  6. 968-IJBCS-Article-Ene Pascal Chuka

    African Journals Online (AJOL)

    T60

    Keywords: Adherent E. coli (DEC); Enteropathogenic E. coli (EPEC); Enteroaggregative E. coli (EAEC);. Diffusely adherent E. coli (DAEC); Mixed Infections; Intestinal Parasites. INTRODUCTION. Among the bacterial causes of diarrhea is Escherichia coli. The diarrheagenic E. coli. (DEC) is the most important bacterial.

  7. Professor Pekka Puska loengud / Ene Indermitte

    Index Scriptorium Estoniae

    Indermitte, Ene, 1967-

    2004-01-01

    Soome Rahvatervishoiu Instituudi direktor, Põhja-Karjala projekti juht prof Pekka Puska peab Tartu ülikoolis loengu "The North Karelia Projekt in Finland and lessons for global chronic disease prevention"

  8. Cultural Trauma and Life Stories / Ene Kõresaar

    Index Scriptorium Estoniae

    Kõresaar, Ene

    2007-01-01

    Aili Aarelaid-Tarti 15-aastase uuringu tulemused raamatus "Cultural Trauma and Life Stories", Hesinki, Kikimora Publications, 2006. Uuritud on kolme suurt rahvusgruppi 1940-test tingitud trauma kontekstis: eestlased kodumaal, eestlased eksiilis ja venekeelne rahvusgrupp Eestis postsovetlikus diskursuses

  9. Küberjulgeolekule teed rajades / Ene Ergma

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2007-01-01

    Riigikogu esimees analüüsib aprillisündmustega kaasnenud küberrünnakute kui ühe terrorismi erivormi tagamaid, toob välja vajaduse kujundada küberrünnakute suhtes Euroopa Liidus ja NATO-s ühtne poliitika

  10. Kas 270 rahvaraamatukogust piisab? / Ene Riet

    Index Scriptorium Estoniae

    Riet, Ene, 1954-

    2016-01-01

    Haldusreformi mõjust rahvaraamatukogude võrgule. Uuringust "Era- ja avalike teenuste ruumilise paiknemise ja kättesaadavuse tagamisest ja teenuste käsitlemisest maakonnaplaneeringute käigus" (2015)

  11. Muutuv Eesti pere / Ene-Margit Tiit

    Index Scriptorium Estoniae

    Tiit, Ene-Margit, 1934-

    2008-01-01

    Ettekanne Vabariigi Presidendi akadeemilise nõukogu ja Tallinna Ülikooli korraldatud konverentsil "Jätkusuutlik Eesti" 25. mail 2006. a. Tallinnas. Euroopa perekonna muutumisest 20. sajandi esimesest poolest 21. sajandini, perekonna eluviisi ja elustiili muutumisest Eestis, tänapäeva Eesti pere elujärjest ja sellega rahulolust. Lisatud statistilised diagrammid ja joonised

  12. Alfred Vogel / Jasmiin-Ene Kallas

    Index Scriptorium Estoniae

    Kallas, Jasmiin-Ene

    1999-01-01

    Ravimtaimede tundja, rändur, toitumisteadlane, publitsist, maailmamainega lektor, ühe tuntuima firma Bioforce AG looja shveitslane Alfred Vogel (1902-1996). Järgneb 1.,8.,15.,22.,29. dets. ; 2000, 5.,12.,19. jaan.

  13. Redetermination of cyclo-trimethyl-ene-trinitramine.

    Science.gov (United States)

    Hakey, Patrick; Ouellette, Wayne; Zubieta, Jon; Korter, Timothy

    2008-07-09

    The redetermined structure of 1,3,5-trinitro-1,3,5-triaza-cyclo-hexane, C(3)H(6)N(6)O(6), at 90 (2) K has ortho-rhom-bic (Pbca) symmetry. It is of inter-est with respect to energetic compounds. The structure was originally investigated through X-ray diffraction by Hultgren [(1936). J. Chem. Phys.4, 84]. Later X-ray investigations were completed by McCrone [(1950). Anal. Chem.22, 954-955] and Harris, Reed & Gluyas [(1959). AFOSR-TR-59-165 Ohio State University Research Foundation, Columbus, Ohio, USA]. A single-crystal neutron diffraction study was performed by Choi & Prince [(1972). Acta Cryst. B28, 2857-2862] to ascertain the H-atom positions, which had not been defined by the earlier X-ray diffraction studies. All previous studies were performed at or near room temperature. The structure provided is the α polymorph of the title compound. The ring atoms are arranged in the chair conformation with two nitro groups occupying pseudo-equatorial positions and the remaining nitro group is axial. The crystal packing is stabilized by close intramolecular interactions from one H atom in each methylene group to O atoms of adjacent nitro groups, ranging from 2.251 to 2.593 Å.

  14. Uued suunad ID-maailmas / Ene Vihtla

    Index Scriptorium Estoniae

    Vihtla, Ene

    2010-01-01

    Alates 2010. aasta oktoobrist väljastab Politsei- ja Piirivalveamet digitaalset isikutunnistust ehk digi-ID. 1. jaanuarist muutuvad ID-kaartide turvamärgid ja Eestis elavatele välismaalastele, kes ei ole EL-i kodanikud, hakatakse ID-kaardi asemel välja andma elamisloakaarti

  15. Eesti Etnograafia Ring Kanadas / Ene Runge

    Index Scriptorium Estoniae

    Runge, Ene, 1919-1999

    1993-01-01

    Etnograafia Ring looodi 1971.a ja on pidevalt õpetanud käsitööd, pidanud loenguid eesti ja inglise keeles, korraldanud näitusi ja loonud eesti sektsiooni Royal Ontario Museumi ja Canadian National Museumi juurde kultuurivara säilitamiseks. Seltsi 20. aastapäevaks oli välja antud 61 õppekirja, lisaks õpetused ajakirjas "Triinu" ja õppefilmid, fotod ja diapositiivid, abi on antud samasugustele ringidele Rootsis ja Austraalias, ERM-ile saadeti 1991. a üle 200 rahvakultuuri eseme

  16. Kaitseliit vajas Naiskodukaitse toetust / Ene Puusemp

    Index Scriptorium Estoniae

    Puusemp, Ene, 1942-

    2007-01-01

    Tartu Linnamuuseumis avatud näitusest "Õed Soome lahe kahelt kaldalt", kus tutvustatakse 1921. aastal loodud Soome naisorganisatsiooni Lotta Svärd ja ja 1927. aastal Eestis moodustatud Naiskodukaitse arengulugu

  17. Human foibles and psychoanalytic technique: Freud, Ferenczi, and Gizella Palos.

    Science.gov (United States)

    Kilborne, Benjamin

    2008-03-01

    This paper explores relations between human conundrums and psychoanalytic technique and theory through the relationship between Freud and Ferenczi. Rather than vilify (or lionize) either figure, the paper seeks to see into their struggles and conflicts, and to draw from correspondence and writings a portrait of a relationship. The paper describes not two dusty figures drawn from the closet of history but rather two live, flawed, and struggling human beings whose rational ideas about what they were doing could never keep step with their emotions. There is therefore much to be learned from their relationship: about transference and countertransference, about boundaries and friendship, about rivalry and despair, and about shame.

  18. Pen and Pal are nucleotide-sugar dehydratases that convert UDP-GlcNAc to UDP-6-deoxy-D-GlcNAc-5,6-ene and then to UDP-4-keto-6-deoxy-L-AltNAc for CMP-pseudaminic acid synthesis in Bacillus thuringiensis.

    Science.gov (United States)

    Li, Zi; Hwang, Soyoun; Ericson, Jaime; Bowler, Kyle; Bar-Peled, Maor

    2015-01-09

    CMP-pseudaminic acid is a precursor required for the O-glycosylation of flagellin in some pathogenic Gram-negative bacteria, a process known to be critical in bacterial motility and infection. However, little is known about flagellin glycosylation in Gram-positive bacteria. Here, we identified and functionally characterized an operon, named Bti_pse, in Bacillus thuringiensis israelensis ATCC 35646, which encodes seven different enzymes that together convert UDP-GlcNAc to CMP-pseudaminic acid. In contrast, Gram-negative bacteria complete this reaction with six enzymes. The first enzyme, which we named Pen, converts UDP-d-GlcNAc to an uncommon UDP-sugar, UDP-6-deoxy-D-GlcNAc-5,6-ene. Pen contains strongly bound NADP(+) and has distinct UDP-GlcNAc 4-oxidase, 5,6-dehydratase, and 4-reductase activities. The second enzyme, which we named Pal, converts UDP-6-deoxy-D-GlcNAc-5,6-ene to UDP-4-keto-6-deoxy-L-AltNAc. Pal is NAD(+)-dependent and has distinct UDP-6-deoxy-d-GlcNAc-5,6-ene 4-oxidase, 5,6-reductase, and 5-epimerase activities. We also show here using NMR spectroscopy and mass spectrometry that in B. thuringiensis, the enzymatic product of Pen and Pal, UDP-4-keto-6-deoxy-L-AltNAc, is converted to CMP-pseudaminic acid by the sequential activities of a C4″-transaminase (Pam), a 4-N-acetyltransferase (Pdi), a UDP-hydrolase (Phy), an enzyme (Ppa) that adds phosphoenolpyruvate to form pseudaminic acid, and finally a cytidylyltransferase that condenses CTP to generate CMP-pseudaminic acid. Knowledge of the distinct dehydratase-like enzymes Pen and Pal and their role in CMP-pseudaminic acid biosynthesis in Gram-positive bacteria provides a foundation to investigate the role of pseudaminic acid and flagellin glycosylation in Bacillus and their involvement in bacterial motility and pathogenicity. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  19. Pen and Pal Are Nucleotide-Sugar Dehydratases That Convert UDP-GlcNAc to UDP-6-Deoxy-d-GlcNAc-5,6-ene and Then to UDP-4-Keto-6-deoxy-l-AltNAc for CMP-Pseudaminic Acid Synthesis in Bacillus thuringiensis*♦

    Science.gov (United States)

    Li, Zi; Hwang, Soyoun; Ericson, Jaime; Bowler, Kyle; Bar-Peled, Maor

    2015-01-01

    CMP-pseudaminic acid is a precursor required for the O-glycosylation of flagellin in some pathogenic Gram-negative bacteria, a process known to be critical in bacterial motility and infection. However, little is known about flagellin glycosylation in Gram-positive bacteria. Here, we identified and functionally characterized an operon, named Bti_pse, in Bacillus thuringiensis israelensis ATCC 35646, which encodes seven different enzymes that together convert UDP-GlcNAc to CMP-pseudaminic acid. In contrast, Gram-negative bacteria complete this reaction with six enzymes. The first enzyme, which we named Pen, converts UDP-d-GlcNAc to an uncommon UDP-sugar, UDP-6-deoxy-d-GlcNAc-5,6-ene. Pen contains strongly bound NADP+ and has distinct UDP-GlcNAc 4-oxidase, 5,6-dehydratase, and 4-reductase activities. The second enzyme, which we named Pal, converts UDP-6-deoxy-d-GlcNAc-5,6-ene to UDP-4-keto-6-deoxy-l-AltNAc. Pal is NAD+-dependent and has distinct UDP-6-deoxy-d-GlcNAc-5,6-ene 4-oxidase, 5,6-reductase, and 5-epimerase activities. We also show here using NMR spectroscopy and mass spectrometry that in B. thuringiensis, the enzymatic product of Pen and Pal, UDP-4-keto-6-deoxy-l-AltNAc, is converted to CMP-pseudaminic acid by the sequential activities of a C4″-transaminase (Pam), a 4-N-acetyltransferase (Pdi), a UDP-hydrolase (Phy), an enzyme (Ppa) that adds phosphoenolpyruvate to form pseudaminic acid, and finally a cytidylyltransferase that condenses CTP to generate CMP-pseudaminic acid. Knowledge of the distinct dehydratase-like enzymes Pen and Pal and their role in CMP-pseudaminic acid biosynthesis in Gram-positive bacteria provides a foundation to investigate the role of pseudaminic acid and flagellin glycosylation in Bacillus and their involvement in bacterial motility and pathogenicity. PMID:25414257

  20. Age determination, validation, and growth of Brazilian flathead (Percophis brasiliensis from the southwest Atlantic coastal waters (34°-41°S Determinación de edad, validación y crecimiento del pez palo (Percophis brasiliensis de aguas costeras del Atlántico sudoccidental (34°-41°S

    Directory of Open Access Journals (Sweden)

    Alfredo C Barretto

    2011-07-01

    Full Text Available The age and growth parameters of Brazilian flathead, Percophis brasiliensis, from the southwest Atlantic coastal waters (34°-41°S were determined for samples collected in spring (n = 853; years 1998 and 2000 and winter (n = 596; year 2004, whereas age was validated through the edge analysis of otoliths collected in 2007 (n = 1367 otoliths. The indices of precision APE, V, and D were used to test the reproducibility, between agers, of the ages determined from 845 otoliths. Maximum determined ages were 19 years for males and 15 years for females. One opaque and one translucent band are laid down per year, in the sagittal otolith. According to the APE (0.668%, V (1.121%, and D (0.647% indices, the age determination was consistent. Von Bertalanffy's growth parameters [males: spring (L∞ = 58.1 cm, k = 0.26 year-1, t0= -2.02 years, winter (L∞ = 58.7 cm, k = 0.21 year-1, t0 = -2.90 years; females: spring (L∞ = 65.2 cm, k = 0.29 year-1, t0 = -1.15 years, winter (L∞= 63.5 cm, k = 0.26 year-1, t0 = -2.01 years] were significantly different between sexes and seasons. From the first year of life, females grow faster and reach greater lengths than males of the same age due, probably, to an asynchronism in the sexual maturity.Se determinó la edad y los parámetros de crecimiento del pez palo, Percophis brasiliensis, de aguas costeras del Atlántico sudoccidental (34°-41°S en muestras obtenidas durante primavera (n = 853; años 1998 y 2000 e invierno (n = 596; año 2004, mientras que la edad fue validada mediante análisis del tipo de borde de otolitos colectados durante 2007 (n = 1367 otoliths. Los índices de precisión APE, V, y D fueron usados para probar la reproducibilidad, entre lectores, de las edades determinadas a partir de 845 otolitos. Las edades máximas determinadas fueron 19 años para machos y 15 años para hembras. Una banda opaca y una translúcida se depositan anualmente en el otolito sagitta. Los índices APE (0,668%, V (1

  1. Environmental analysis of a formerly utilized MED/AEC site: Site A and plot M, Palos Forest Preserve, Palos Park, Illinois

    Energy Technology Data Exchange (ETDEWEB)

    1979-09-01

    This environmental analysis report describes the existing site environment and evaluates the environmental impacts of 8 options for remedial action, including allowing buried waste to remain undisturbed. Conformity or conflict with governmental statutes, regulations and standards was determined, especially with regard to compliance with contamination criteria and guidelines. The program of measurements, documentation, and control to demonstrate compliance with these criteria and guidelines was identified.

  2. Puhtus ja kord majas ning mõtetes / Ene Vool

    Index Scriptorium Estoniae

    Vool, Ene, 1948-

    2007-01-01

    Kalle Rõõmuse projekteeritud inimese bioenergiast lähtuvast eramust, kus raudse järjekindlusega kasutati energeetilisest seisukohast ülimalt inimsõbralikke loodusmaterjale - mida vähem materjale, seda vähem väljamõjusid. Sisearhitekt oli Terje Kivist. Kalle Rõõmuse kommentaar

  3. Episteemilise loogika mõningad aspektid / Ene Grauberg

    Index Scriptorium Estoniae

    Grauberg, Ene, 1944-

    2004-01-01

    Episteemiline loogika on modaalse loogika alasüsteemi loogika teooria, mis kasutab episteemilise operaatoreid ...teab,et..., ...eeldab,et.... Tema aineks on neid operaatoreid sisaldavate otsustuste õige organiseerimise reeglid ja tingimused. Varem ilmunud: Metod modelirovanija i nekotorõje filosofskije problemõ istorii i metodologii jestestvoznanija. Tallinn, 1975.

  4. Lapsevanemate osalemine koolielus ja rahulolu kooliga / Eda Heinla, Ene Pill

    Index Scriptorium Estoniae

    Heinla, Eda, 1953-

    2008-01-01

    Artikkel analüüsib lapsevanemate koostööd kooliga, hinnanguid koolitöös osalemise võimalustele, nägemusi kooli hoolekogu ülesannetest ning rahulolu lapse kooli suhtes. Artikkel põhineb Tallinna üldhariduskoolide õpilaste vanemate küsitlusel

  5. Panaches horizontaux non-Boussinesq en milieu homog\\`ene

    CERN Document Server

    Daddi-Moussa-Ider, Abdallah; Mehaddi, Rabah; Vauquelin, Olivier; Candelier, Fabien

    2014-01-01

    The environmental impact of pollutants and effluents discharged into the atmosphere or the oceans has led researchers to conduct studies related to this issue. Several works have been carried out in this context in order to reduce the effect on the local environment. These types of ejections in nature are modeled as jets in the presence of a density gradient. In this study we treated the problem of inclined round turbulent buoyant jets and plumes ejected in a homogeneous or stratified fluid, at rest or in motion. The prediction of the flow behavior, i.e. the evolution of its variables, is first treated theoretically from a model whose formalism is valid in both the Boussinesq case as well as in the non-Boussinesq general case. Solving the equations governing the plumes is performed numerically using a Runge-Kutta 4th order. To validate the model, laboratory experiments are performed with round jets of air and helium for a wide range of densities. The confrontation theory-experience aims here to fix the limits...

  6. Läänemeri vs Nord Stream / Ene Kaups

    Index Scriptorium Estoniae

    Kaups, Ene, 1963-

    2009-01-01

    Riigikogu võttis vastu avalduse Läänemerre kavandatava gaasijuhtmega seotud keskkonnariskidest, kus avaldatakse muret, et Nord Stream AG poolt algatatud gaasijuhtme projekti rahvusvahelise keskkonnamõju hinnangutes ei ole piisavalt arvestatud kõigi seonduvate keskkonnariskidega

  7. Leedu graafika Tartus / Ene Asu-Õunas

    Index Scriptorium Estoniae

    Asu-Õunas, Ene, 1943-

    1999-01-01

    Näitus "Leedu graafika iseseisvusaastatel" Kaunase rahvusliku M. K. Ciurlionise nimelise kunstimuuseumi kogudest 26. veebr.-st Tartu Kunstimuuseumis. Esindatud 21 autori teosed. Rahvusvaheliselt tuntumaid kunstnikke Aldomas Galdikas.

  8. Ain Prosa ja Surma õpipoiss / Ain Prosa ; interv. Ene Paaver

    Index Scriptorium Estoniae

    Prosa, Ain, 1967-

    2001-01-01

    Terry Pratchetti "Mort - Surma õpipoiss" Eesti Draamateatris, lavastaja Ain Prosa. Lavastajast ja tema töödest. Arvavad ka stsenarist Mihkel Ulman, näitleja Pille Lukin ja Rakvere teatri direktor Indrek Saar

  9. ŽENE I SPORT U CRNOJ GORI

    Directory of Open Access Journals (Sweden)

    Cheryl Cooky

    2011-08-01

    Full Text Available This paper is part of a larger study that identifies who plays sport in Montenegro, and the factors (family, education, economic, religious, cultural stereotypes, and so on that contribute to girls and women’s participation in sport or that limit girls and women’s participation in sport. This study is the first evidencebased research assessing the current status of girls and women’s sport participation in Montenegro, at all institutional levels. Using mixed-methodologies (quantitative assessment, survey data and qualitative focus group interviews this study will determine the numbers of girls and women participating in sport, as compared to boys and men in similar demographic categories, and to examine why girls and women do or do not participate in sport and what are their experiences in sport. Initial findings from the demographic assessment of sport in Montenegro illustrate overall gender disparities in sport participation in the 7 most popular sports; the majority of athletes, coaches, managers and decision-makers, medical staff, referees and sport delegates were men. We found the greatest gender imbalance in soccer and basketball, which were overwhelmingly male-dominated, and the greatest gender parity in handball and volleyball- and in some cases there were more female participants than male participants in these sports. We also examined overall trends in gender and sport participation across the different geographical regions, which were similar. However, there were differences in the types of sports men and women played in the different regions, which may indicate that some sports were more popular, or accepted, or easier to access for women in the central part of the country while other sports were more popular, or accepted or easier to access for women in the northern and southern regions. The project is a collaborative partnership with US- and Montenegro based scholars, the International Olympic Committee, the Montenegrin Olympic Committee, the United Nations Development Program, the Office for Gender Equality of the Ministry for Human and Minority Right of Montenegro, and NGO Inovativnost. Reflections and insights on multi-institutional partnerships in the study gender and sport participation will be offered.

  10. Iseloomuga majad, vol 1 / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2008-01-01

    Eesti Arhitektide Liidu korraldatud konkursi "Eramu 2006-2007" nominendid: 1. Funkvilla Nõmmel (arhitekt Andres Ringo); 2. Villa Tabasalus (arhitekt Tiit Trummal); 3. Sõlmes alumiiniummaja (arhitektid Peeter Pere, Urmas Muru); 4. Etnomodernne palkmaja (arhitektid Tauno Aadma, Laur Pihel); 5. Villa Kurepesa Pirita jõekäärus (arhitekt Kalle Rõõmus); 6. Vaskvilla Võrus (arhitekt Karmo Tõra)

  11. Iseloomuga majad, vol 2 / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2008-01-01

    Eesti Arhitektide Liidu korraldatud konkursi "Eramu 2006-2007" nominendid: 1. Vonklev arhitektimaja (arhitekt Karmo Tõra); 2. Betoonmaja Kloogarannas (arhitektid Laur Pihel, Tauno Aadma); 3. Funktalu Jõgisool (arhitekt Jaak Huimerind); 4. Villa Kakumäel (arhitekt Tiina Kaljundi); 5. Räästamaja Suurupis (arhitekt Raul Vaiksoo); 6. Klotsidest maja (arhitekt Eero Palm, kaasautor Kristiina Ott)

  12. Tööjuhendid loovuse arendajana / Ene Lind

    Index Scriptorium Estoniae

    Lind, Ene

    2001-01-01

    Loovuse arendamine tööõpetuse ja käsitöö tunnis. Katsest Tallinna koolide 2. ja 4. klasside õpilaste seas, milles katsetati kaht töö raskusastme ning kasutatavate materjalide ja töövahendite poolest erinevat tööjuhendit. Katse järel viidi läbi küsitlus, kus lapsed andsid hinnangu ja kommenteerisid tööjuhendi järgi iseseisvalt töötamist tööõpetuse tunnis

  13. Videomuinasjutt algastme eesti keele tundi : miks ka mitte? / Ene Peterson

    Index Scriptorium Estoniae

    Peterson, Ene

    2002-01-01

    Rets. : Tungal, Leelo. Videomuinasjutt "Printsess Mari ja konn Konrad" [Videosalvestis] = A fairytale on video "Princess Mari and frog Konrad". - Tallinn : Elav Teadus, 1993. - 1 videokassett (VHS) (120 min) + 1 raamat (32 lk.)

  14. 500-tonniste muldseintega elamu / Ene Läkk, Helen Urbanik

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Arhitekt Rick Joy projekteeritud arst John Palmeri villa USAs Arizona osariigis, Santa Catalina mäestiku jalamil. Hoone ühes osas asuvad perekonna eluruumid, teine on avatud ruum. Pressitud muldseinad ja liblikatiiva kujulised terasest katusesiilud jäljendavad ümbritseva maastiku vorme. Suuri seina- ja aknapindu katab raamimata klaas.

  15. Põllumajandussaaduste turg : [1994-2003 Eestis] / Ene Maadvere

    Index Scriptorium Estoniae

    Maadvere, Ene, 1948-

    2004-01-01

    Ilmunud ka: Agriculture and rural development : overview 2003/2004. - Tallinn, 2004, lk. 124-132. Põllumajandussaaduste ekspordimaht vähenes 2003. a. eelmise aasta sama perioodiga võrreldes 0,4%, importmaht aga suurenes 7%. Tabelid. Diagrammid. Graafikud

  16. Phytochemical Screening and Characterization of Olean-18-ene ...

    African Journals Online (AJOL)

    http://dx.doi.org/10.4314/star.v4i1.15 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER RESOURCES... for Researchers · for Journals · for Authors · for Policy Makers ...

  17. Sotsiaal-majanduslik staatus tervise tausttegurina / Margo Kikas, Ene Lausvee

    Index Scriptorium Estoniae

    Kikas, Margo

    2008-01-01

    Uuringust seoste kohta Eesti inimeste tunnetatud tervise ning sotsiaal-majandusliku ja psühhosotsiaalse seisundi vahel. Uuring tugineb Tallinna Ülikooli sotsiaaltöö eriala üliõpilaste poolt aastatel 2001-2002 tehtud anonüümsel ankeetküsitlusel põhiliselt toimetulekuraskuste, krooniliste haiguste, puudega või riskikäitumisega isikute seas

  18. Prantsusmaale oma lõhna looma / Ene Poll

    Index Scriptorium Estoniae

    Poll, Ene

    2001-01-01

    Prantsusmaa väikelinnas Grasses, maailma parfümeeriakeskuses, on võimalik tutvuda Galimardi vabriku tootmisprotsessiga, lõhnaõli muuseumiga ja lõhnaloomisstuudios valmistada endale ise ainukordne parfüüm

  19. Otsused andmekandjate kohta kriminaalmenetluses: proportsionaalsusnõudega arvestamine / Eneli Laurits

    Index Scriptorium Estoniae

    Laurits, Eneli

    2016-01-01

    Riigikohtu lahendist nr. 3-1-1-57-12, proportsionaalsuse nõude rakendamisest asitõendi (andmekandja) täieliku hävitamise korral alamaastmete kohtute praktikas. Sisaldab 2013-2015 aastate asjakohast kohtupraktikat

  20. Preparation of Novel Hydrolyzing Urethane Modified Thiol-Ene Networks

    Science.gov (United States)

    2011-10-25

    networks will influence the rate in which water is absorbed into the film. This work represents the preliminary characterization of the hydrolysis of...Linossier, I.; Peron , J.J.; Langlois, V.; Vallee-Rehel, K. Antifouling activity of marine paints: Study of erosion. Prog. Org. Coat. 2007, 60, 194-206

  1. Hüdra aastasada / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet

    1997-01-01

    Arvustus: Galsworthy, John. Peatüki lõpp : Üle jõe / tlk. Jüri ja Liisi Ojamaa. Tallinn : Eesti Raamat, 1997; Amis, Kingsley. qnneseen Jim / tlk. Urve Hanko. Tallinn : Eesti Raadio, 1997; Boyd, William. Sinine pärastlõuna / tlk. Virve Krimm. Tallinn : Varrak, 1997. Briti XX saj. kirjanduse ülevaade

  2. Modernse arhitektuuri ja okupatsioonimuuseumi liit / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2001-01-01

    Okupatsioonimuuseumi ideest ja teostamisest. Avaliku arhitektuurivõistluse "Lähimineviku okupatsioonide muuseum" võitjad: I preemia: Indrek Peil, Siiri Vallner, II preemia Tiina Teng, Peeter Loo, III preemia Reio Avaste (AS Arhitektuuribüroo Eek & Mutso), ostupreemia: Margus (?) Kaasik, Kalle Komissarov, Andres Ojari, Indrek Tiigi, Ilmar Valdur (Arhitektuuribüroo Kolm Pluss Üks OÜ), ostupreemia: Andres Kask

  3. Ehte näitamise kunst / Ene Poll

    Index Scriptorium Estoniae

    Poll, Ene

    2009-01-01

    Tanel Veenre isikunäitus "Ehe" Rotermanni Nisurukkiveskis 24.-30. oktoobrini. Eksponeeritud 29 ehet on valminud viimase kolme aasta jooksul. Näitusega koos ilmus autoriraamat "Ehe", mis räägib kunsti ja kunstniku suhtest

  4. Fluoriidid Eesti elanike joogivees / Astrid Saava, Ene Indermitte

    Index Scriptorium Estoniae

    Saava, Astrid, 1938-

    2007-01-01

    Eesti elanike joogivee-uuringust, mis tehti 2004. aastal Eesti Stomatoloogia Seltsi tellimisel. Lisad: Eesti elanike joogivee fluoriidisisalduse kaart. Elanike jaotus tarbitava joogivee fluoriidisisalduse alusel maakonniti

  5. Kooli tehnoloogiaõpetus tuleb atraktiivseks muuta / Ene Lind

    Index Scriptorium Estoniae

    Lind, Ene, 1954-

    2010-01-01

    Üleeuroopalisest tehnoloogiaõppe edendamise projektist "Understanding and Providing a Developmental Approach to Technology Education" - UPDATE ("Tehnoloogiaõpetuse arenguvõimaluste mõistmine ning rakendamine"). Jyväskylä Ülikooli juhtimisel tegid koostööd 16 Euroopa haridus- ja teadusasutust, Eestit esindas Tallinna Ülikooli tööõpetuse osakond koos Eesti Tehnoloogiakasvatuse Liiduga

  6. Minimalismi asemele hiilib barokk / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    1999-01-01

    Trendikatest jõulukompositsioonidest. Nõu annavad Stockholmi kuusekaunistamise maailmameistrivõistluse maailmameistrid Taivo Piller ja Mart Haber. T. Pilleri parim õpetaja - norra lilleseadja Linda Johansen.

  7. Ainenõukogu tähelepanekuid / Ene Laanes

    Index Scriptorium Estoniae

    Laanes, Ene

    2003-01-01

    Üleriigiline kehalise kasvatuse ainenõukogu peab vajalikuks juhtida haridusametnike, koolijuhtide ja kooli omanike tähelepanu kehalise kasvatuse ainekava läbiviimisel üles kerkinud probleemidele: meditsiinilisse erigruppi kuuluvate õpilaste hindamine kehalise kasvatuse aines, kehalise kasvatuse tunniks vajalikud harjutuspaigad ja vahendid, nädalatundide arv

  8. Production of 4-Ene-3-ketosteroids in Corynebacterium glutamicum

    Directory of Open Access Journals (Sweden)

    Julia García-Fernández

    2017-10-01

    Full Text Available Corynebacterium glutamicum has been widely used for the industrial production of amino acids and many value-added chemicals; however, it has not been exploited for the production of steroids. Using C. glutamicum as a cellular biocatalyst we have expressed the 3β-hydroxysteroid dehydrogenase/isomerase MSMEG_5228 from Mycobacterium smegmatis to demonstrate that the resulting recombinant strain is able to oxidize in vivo C19 and C21 3-OH-steroids to their corresponding keto-derivatives. This new approach constitutes a proof of concept of a biotechnological process for producing value-added intermediates such as 4-pregnen-16α,17α-epoxy-16β-methyl-3,20-dione.

  9. Võrumaa mitmekesisuse võlu / Ere Raag ; intervjueerinud Ene Riet

    Index Scriptorium Estoniae

    Raag, Ere

    2015-01-01

    Võrumaa Keskraamatukogu pearaamatukoguhoidja räägib, kuidas ja miks valis ta oma erialaks raamatukogunduse, kus ja kellena ta on töötanud ning mida on raamatukogundus talle andnud. Arutletakse ka raamatukogunduse ning raamatukoguhoidja tuleviku üle

  10. 3α-Dimethylamino-20-(N-methylacetamidopregn-5-ene

    Directory of Open Access Journals (Sweden)

    S. Yousuf

    2011-11-01

    Full Text Available The title compond, C26H44N2O, is an steroidal alkaloid isolated from the medicinally important plant Sarcococca saligna. The molecule consists of four fused rings (A–D, having chair, half-chair, chair and envelope conformations, respectively. The dimethylamino group is axially oriented on ring A, whereas the (N-methylacetamidoethyl group is attached equatorially on ring D. The crystal structure is stabilized only by van der Waals forces.

  11. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    DEFF Research Database (Denmark)

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet...

  12. Tuul väljal / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet

    1997-01-01

    Arvustus: Woolf, Virginia. Esseed/ inglise k. tlk. Malle Talvet, Jaak Rähesoo. Tallinn : Hortus Litterarum, 1997; Woolf, Virginia. Orlando : elulugu / inglise k. tlk. Riina Jesmin. Tallinn : Perioodika, 1997. (Loomingu Raamatukogu; 31-34)

  13. Põllumajandussaaduste eksport ja import Eestis 1995. aastal / Ene Maadvere

    Index Scriptorium Estoniae

    Maadvere, Ene, 1948-

    1996-01-01

    Tabelid: Kaupade eksport ja import Eestis; Põhiliste kaubagruppide osatähtsuse muutumine toidukaupade ekspordis; Hinnad; Mõnede toidukaupade eksport 1995.a. võrreldes 1994.a.; Imporditud toidukaupade struktuur võrreldes 1995.a.; Nisuhind Chicago börsil. Diagrammid: Liha-piima tootmine, tarbimine, eksport ja tonnides; Põllumajandussaaduste eksport 1995.a. riikide lõikes

  14. Euroopa kõige ilusamad hotellid / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2007-01-01

    Hotel Puerta America Madridis, mille on kujundanud 19 maailmakuulsat disainerit. Hotell Luzernis, kus laekujunduses on kasutatud filmikaadreid. Hotell Lute Suites Hollandis. Duomo Hotel Riminis, kujundus Ron Arad'ilt. Kruisherenhotel Maastrichtis

  15. Tandem Wittig-ene reaction approach to kainic acid

    Digital Repository Service at National Institute of Oceanography (India)

    Majik, M.S.; Parameswaran, P.S.; Tilve, S.G.

    bromide (1 equiv) in CH 3 CN (2 mL) over a period of 10 min in an ice cold water bath. The reaction mixture was stirred for1hatroom temperature and then concentrated under reduced pressure. Purification of residue by column chromatography on silica gel... solution of bromoacetyl bromide (1.2 equiv) in CHCl 3 (1 mL) at 0 °C over a period of 10 min. The reaction mixture was then stirred for1hatroom temperature and diluted with water (20 mL), and product was extracted with CHCl 3 (3 × 20 mL). The organic phase...

  16. Mentor - mis see veel on? / Ene-Silvia Sarv

    Index Scriptorium Estoniae

    Sarv, Ene-Silvia

    2001-01-01

    Mentori rollist praktikantide, kutseaastat sooritavate ja uute õpetajate juhendajana, klassijuhatajate ja aineõpetajate nõustajana, kontaktisikuna noorte õpetajate ettevalmistamisel ülikoolis. TPÜ magistrantide mentorirühma projektseminaril "Mentori roll lähituleviku Eesti koolis" ja TÜ mentorirühma õppustel olid teoreetilise põhikursuse kõrval arutusel mentorite praktilise rakendamise võimalused. Analüüsi põhjal tuletati mentorluse neli võimalikku stsenaariumi

  17. Lapse ülalpidamise hind / Ene-Margit Tiit

    Index Scriptorium Estoniae

    Tiit, Ene-Margit, 1934-

    2005-01-01

    Tutvustav artikkel sotsiaalministeeriumi tellimusel läbiviidud uuringust, mille eesmärgiks oli välja töötada lapse kõikidest vajadustest lähtuv ühtne metoodika lapse ülalpidamiskulude arvutamiseks ühes kuus. Tabelid. Diagrammid. Vt. ka lk. 15-16: Kaplan, Signe. Metoodika kasutamisvõimalusi

  18. Õppimine - argine? / Ene-Silvia Sarv

    Index Scriptorium Estoniae

    Sarv, Ene-Silvia

    2001-01-01

    Tagasivaateliselt õppimise uurimisest ja õppimise tähtsuse suurenemisest 20. sajandil. Õppimise käsitlusi. Aju ja õppimine, ajupõhise õppimise põhimõtted ja seosed õppekava, õpetamise ja hindamisega

  19. People in Ida-Virumaa : between two cultures / Ene Must

    Index Scriptorium Estoniae

    Must, Ene

    2002-01-01

    Peamistest probleemidest Ida-Virumaal, Sillamäel ja Narvas. Kohalike elanike seas läbi viidud Eesti sotsioloogide, Eesti integratsioonifondi ja Saar Polli uuringufirma uurimusest, kus uuriti nende sidemeid naaberriikidega, majanduslikku olukorda ning nende võimalikku elukoha muutust seoses majandusliku olukorraga Eestis ja liitumisega EL-iga. Kokkuvõtted uuringu tulemustest. Diagrammid

  20. Ühest poisist : film ja raamat / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene

    2002-01-01

    Mängufilm "Suur poiss ja väike poiss" ("About a Boy") : režissöörid Paul ja Chris Weitz : Suurbritannia - Ameerika Ühendriigid - Prantsusmaa 2002. Võrdlus filmi ja selle aluseks olnud Nick Hornby romaani "Ühest poisist" vahel

  1. Options for In Situ Capping of Palos Verdes Shelf Contaminated Sediments

    Science.gov (United States)

    1999-03-01

    Cosmochemica Acta 58. 1243-49. Boyer, J. M., Chapra , S. C., Ruiz, C. E., and Dortch, M. S. (1994). “RECOVERY, a mathematical model to predict the...NJ. Boyer, J. M., Chapra , S. C., Ruiz, C. E., and Dortch, M. S. (1994). “RECOVERY, a mathematical model to predict the temporal response of surface

  2. DOE ZERH Case Study: Palo Duro Homes, Via del Cielo, Santa Fe, NM

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning production home in the mixed-dry climate that got a HERS 48 without PV, with 2x6 24” on center walls with R-21 blown fiberglass; slab foundation with R-10 under slab and R-5rigid foam at slab edge; vented attic with R-75 blown fiberglass; ducted minisplit heat pump 16.5 SEER, 9.5 HSPF.

  3. 77 FR 60672 - Grant of Authority for Subzone Status; Tesla Motors, Inc., (Electric Passenger Vehicles), Palo...

    Science.gov (United States)

    2012-10-04

    ... Foreign-Trade Zones Board Grant of Authority for Subzone Status; Tesla Motors, Inc., (Electric Passenger... electric passenger vehicles and related powertrain components at the Tesla Motors, Inc., facilities located... establish a special-purpose subzone at the electric passenger vehicle manufacturing facilities of Tesla...

  4. "Improvizz" toob Tartu Ülikooli aula lavale improvisatsiooniorkestri / Karin Palo

    Index Scriptorium Estoniae

    Palo, Karin

    2005-01-01

    Neljandast rahvusvahelisest improvisatsioonilise muusika festivalist "Improvizz" (festivali peakorraldajaks Aleksander Sünter). Kontserdid: "Opera Kit" 4. märtsil Tartu Sadamateatris, 5. märtsil Tartu Sadamateatris, 6. märtsil TÜ Ajaloomuuseumis, 6. märtsil "Ettearvamatu lõppkontsert" TÜ aulas

  5. Peagi käivituv riiklik programm aitab kaasa lasteaedade olukorra paranemisele / Urve Palo

    Index Scriptorium Estoniae

    Palo, Urve, 1972-

    2008-01-01

    Selleks, et kaasa aidata sündivuse kasvule ja lastega perede heaolu paranemisele, eraldab riik järgmise nelja aasta jooksul 1,4 miljardit krooni olemasoleva lasteaiavõrgu kvaliteedi parandamiseks, õpetajate palkade tõusuks ja uute lasteaiakohtade loomiseks

  6. Proceedings of Image Understanding Workshop Held in Palo Alto, California on 23-26 May 1989.

    Science.gov (United States)

    1989-05-01

    standards :tcross the IU comunnity . We initially developed the PowerVision environnient Mc(’nnell et.al. - 68I on the SYMBOLICS LISP tiachines using...Carnegie-Mellon University, 1976. [13] Kirkpatrick, S. and R.H. Swendsen, "Statistical Mechanics and Disordered Systems," Comm. of the ACM, Vol. 28, No

  7. Tartust pärit eurolauljate võiduvõimalused vähenesid / Karin Palo

    Index Scriptorium Estoniae

    Palo, Karin

    2005-01-01

    Tänavusest Eesti Eurovisiooni finaalist, lauljast Laura Põldverest lauludega "Moonwalk ja "Let's Get Loud" (viimane ansambli Suntribe koosseisus)" ja Julia Bomani esitatud laulu "Nevermore Island" väljajätmisest finaalvõistlusest

  8. Options for In Situ Capping of Palos Verdes Shelf Contaminated Sediments

    National Research Council Canada - National Science Library

    Palermo, Michael; Schroeder, Paul; Rivera, Yilda; Ruiz, Carlos; Clarke, Doug; Gailani, Joe; Clausner, James; Hynes, Mary; Fredette, Thomas; Tardy, Barbara

    1999-01-01

    .... This study included prioritizing areas of the PV shelf to be capped, determining an appropriate cap design or designs, developing an equipment selection and operations plan for placement of the cap...

  9. The Palo Alto Group: Difficulties and Directions of the Interactional View for Human Communication Research.

    Science.gov (United States)

    Wilder, Carol

    1979-01-01

    Summarizes the theoretical and epistemological bases of the interaction view, noting the pragmatic instances for which this framework is invoked as explanation and justification. Introduces some conceptual and methodological difficulties which need be addressed in formulating appropriate research. Suggests general and specific directions for…

  10. Land disposal of San Luis drain sediments, Panoche Water District, South Dos Palos, California

    Energy Technology Data Exchange (ETDEWEB)

    Zawislanski, Peter; Benson, Sally; TerBerg, Robert; Borglin, Sharon

    2002-07-01

    Lawrence Berkeley National Laboratory (LBNL), LFR Levine-Fricke (LFR), the U.S. Bureau of Reclamation (USBR) and the Panoche Water District, have completed a pilot-scale test of the viability of land application of selenium- (Se-) enriched San Luis Drain (SLD) sediments. The project was initiated in October 1998 by LBNL. LFR assumed the role of primary subcontractor on the project in July 2001. Substantial portions of this report, describing work performed prior to November 2000, were previously prepared by LBNL personnel. The data set, findings, and recommendations are herein updated with information collected since November 2000. Local land disposal is an attractive option due to its low cost and the proximity of large areas of available land. Two modes of disposal are being tested: (1) the application to a nearby SLD embankment, and (2) the application to and incorporation with nearby farm soils. The study of these options considers the key problems that may potentially arise from this approach. These include disturbance of SLD sediments during dredging, resulting in increased downstream Se concentrations; movement of the land-applied Se to groundwater; reduced productivity of farm crops; and Se uptake by wild and crop plants. This report describes field and laboratory activities carried out from 1998 through February 2002, and results of these investigations.

  11. Image Understanding: Proceedings of a Workshop held at Palo Alto, California, 15-16 September, 1982

    Science.gov (United States)

    1982-09-16

    sr:.pt driven situation assessment module, prognosis and plans. The ACRONYM system, which is This latte. module will provide the capability to the...0-V ovt~in-E p, . a-7 = pcos + qsinB \\ ax Figures: Vanishing Point of a Une and at Corollaries of this definition are:q’ . -7 - - psin 8 + q cos ay’ 1

  12. V/STOL Conference, Palo Alto, Calif., June 6-8, 1977, Technical Papers

    Science.gov (United States)

    1977-01-01

    Papers are presented on practical aspects of commercial STOL operations, a Vertical Attitude Takeoff and Landing (VATOL) program, powered-lift STOL ground effects, conceptual design studies of Navy Type A V/STOL aircraft, and a V/STOL shaft propulsion system analytical performance model. Also considered are the management of swirling flows with application to wind tunnel design and V/STOL testing, flight control testing of the VAK-191B, and surface fluctuating pressure measurements on a 1/4-scale YC-14 boilerplate model.

  13. Structure-activity relationships of 3-deoxy androgens as aromatase inhibitors. Synthesis and biochemical studies of 4-substituted 4-ene and 5-ene steroids.

    Science.gov (United States)

    Nagaoka, Masao; Watari, Yoko; Yajima, Hiromi; Tsukioka, Kaoru; Muroi, Yasuyo; Yamada, Keiko; Numazawa, Mitsuteru

    2003-08-01

    As part of our investigation into the structure-activity relationship of a novel class of aromatase inhibitors, two series of 3-deoxy androgens, androst-5-en-17-ones with a non-polar alkoxy (5 and 6), alkyl (20-22), or phenylalkyl (23 and 24) group at C-4beta and 4-acyloxyandrost-4-en-17-ones (29-32, and 34) were synthesized and evaluated. The 4beta-alkyl and 4beta-phenylalkyl compounds were obtained through reaction of 4alpha,5alpha-epoxy steroid (8) with RMgBr (R: alkyl and phenylalkyl) followed by dehydration of the 4beta-substituted 5alpha-hydroxy products (15-19) with SOCl(2) as key reactions. Acylation of 4alpha,5alpha-diol (25) with (RCO)(2)O in pyridine and subsequent dehydration with SOCl(2) gave the 4-acyloxy steroids. All of the steroids studied, except for 4-acetoxy-19-ol (34) that was a non-competitive inhibitor of human placental aromatase, blocked aromatase activity in a competitive manner. 4-Benzoyloxy- and 4-acetoxy steroids (31) and (32) were the most powerful inhibitors of aromatase (K(i)=70 and 60nM, respectively). Elongation of an acetoxy group in a series of 4-acyloxy steroids or a methyl group in a series of 4beta-alkyl steroids decreased affinity for aromatase principally in relation to carbon number of the acyl or alkyl function. The present findings are potentially useful for understanding the spatial and electronic nature of the binding site of aromatase as well as for developing effective aromatase inhibitors.

  14. Minister Palo püüab reklaamiga halli passi omanikke / Aleksei Günter, Aleksei Ivanov, Andrei Babin

    Index Scriptorium Estoniae

    Günter, Aleksei, 1979-

    2008-01-01

    Valitsus alustas mittekodanikele suunatud reklaamikampaaniat "Erinevad inimesed - üks rahvas". Vt. samas: Kai Kalamees. Sünnijärgse kodakondsuse idee põrus riigikogus taas; Kampaania; Kommenteerivad Paul-Eerik Rummo ja Evelyn Sepp

  15. 75 FR 9623 - Arizona Public Service Company, et al.; Palo Verde Nuclear Generating Station, Units 1, 2, and 3...

    Science.gov (United States)

    2010-03-03

    ...-temperature limits identified as `ASME [American Society for Mechanical Engineers] Appendix G limits' in Table... methods of analysis and the margins of safety of Appendix G of Section XI of the ASME Code .'' The regulations in 10 CFR Part 50, Appendix G, also specify the applicable editions and addenda of the ASME Code...

  16. 75 FR 53985 - Arizona Public Service Company, et al., Palo Verde Nuclear Generating Station, Unit 3; Temporary...

    Science.gov (United States)

    2010-09-02

    ... release, hydrogen concentration, and cladding oxidation from the metal- water reaction. The temporary...\\TM\\. The underlying purpose of 10 CFR part 50, Appendix K, Section I.A.5, ``Metal-Water Reaction Rate..., regulations, and orders of the Nuclear Regulatory Commission (NRC, the Commission) now or hereafter in effect...

  17. Reductive dechlorination rate data for 4,4'-DDE in sediments of the Palos Verdes Shelf, CA (1981-2010)

    Data.gov (United States)

    Department of the Interior — Wastes from the world’s largest manufacturer of DDT were released into the Los Angeles County municipal sewer system from 1947 to 1971. Following primary treatment,...

  18. Archaeological Test Excavations at CA-LAn-105, -291, and -1269, Palos Verdes Peninsula, Los Angeles County, California.

    Science.gov (United States)

    1986-08-01

    Ursus horribilis ), coyote (Canis latrans), gray fox (Urocyon cinereoargenteus), raccoon (Procyon lotor), badger (Taxidea taxus), striped skunk...291 or as a locus of CA-LAn-291. In any event, CA-LAn-105 has been severely disturbed and its relationship to CA-LAn-291 totally destroyed by the

  19. Prügilill, vana hõng ja minimalism / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Kahest äärmusest praeguses aiakujunduses: minimalismist ja vanahõngulisest, hästi organiseeritud segadusest. Erinevatest materjalidest terrassist, "woodland'ist", moesolevatest prügitaimedest. Trendinäiteks Saksa saatkonna haljasalast Tallinnas (arhitekt R. Herms, teostus Ü. ja U. Grishakov). Soovitusi maastikuarhitekt Ü. Grishakovilt

  20. Vaesus ja ebavõrdsus = Poverty and inequality / Mari Kreitzberg, Ene-Margit Tiit

    Index Scriptorium Estoniae

    Kreitzberg, Mari

    2004-01-01

    Vaesuse ja ühiskonna sotsiaalsest sidususest, vaesuse määratlemisest, subjektiivsest vaesusest, sissetuleku- ja kuluvaesusest, vaesuspiirist, absoluutsest ning suhtelisest vaesusest. Diagrammid. Tabelid. Graafikud

  1. Whats 'App-ening': the help of new technologies in nutrition in digestive diseases.

    Science.gov (United States)

    Ankersen, Dorit V; Weimers, Petra; Burisch, Johan

    2017-09-01

    The aim of this study is to review the basic concepts of electronic health (eHealth), with a focus on its nutritional applications and its usefulness for digestive diseases. eHealth applications for the treatment and monitoring of digestive disease are growing in number. ehealth helps patients in coping with their disease by promoting self-management, which increases adherence to medical treatment and diets, and leads to an improved quality of life. For irritable bowel syndrome (IBS), there are multiple applications that provide dietary advice, for example, a low FODMAP (Fermentable Oligo, Mono, Disaccharides And Polyols) diet. However, many applications lack a symptom scoring function and do not include a module for assisting the essential reintroduction of high FODMAP foods. In general, there are very few applications that enable direct patient communication with healthcare professionals. A more holistic approach that educates patients and enables them to communicate directly with eCare provider through a web application is one of the functions most requested by patients. eHealth solutions for digestive diseases have a supportive function and a positive impact on patients. However, there is a need to increase patient education and further develop the possibility for care team-patient communication within eHealth solutions.

  2. Õpetaja haridus, kooliharidus ja ühiskond / Ene-Silvia Sarv

    Index Scriptorium Estoniae

    Sarv, Ene-Silvia, 1945-

    1999-01-01

    Rahvusvahelise Haridusentsüklopeedia tekstist ja Eesti õpetajakoolituse uuendamise kavadest inspireeritud mõtisklus. Teoreetilised teadmised, võimed, eeldused, mida peetakse õpetajale vajalikuks, on seotud haridusele omastatavate eesmärkidega

  3. N,N?-(Ethane-1,2-diyldi-o-phenyl?ene)bis?(pyridine-2-carboxamide)

    OpenAIRE

    Sarkar, Shuranjan; Lee, Hong-In

    2011-01-01

    The title molecule, C26H22N4O2, is centrosymmetric and adopts an anti conformation. Two intramolecular hydrogen bonds, viz. amide–pyridine N—H...N and phenyl–amide C—H...O, stabilize the trans conformation of the (pyridine-2-carboxamido)phenyl group about the amide plane. In the crystal, the presence of weak intermolecular C—H...O hydrogen bonds results in the formation of a three-dimensional network.

  4. Meistrid : [luuletused] / Lajos Kassák ; tlk. Ene Asu-Õunas

    Index Scriptorium Estoniae

    Kassák, Lajos

    2004-01-01

    Sisu: Meistrid ; "Tulin kõrvaltänavast 11 sõbraga, olime maakad ja virginia ..." ; "Siniste linade all lamavad minu surnud ..." ; "Seisan värava juures, unustatud maja värava juures ehavalguses ..." ; Kauge tervitus ; Kõnelen meie surnutest ; Täiskuu ; Emake valvab meid ; Suletud värava ees ; Béla Bartók ; Surnud sõdurid ; Ühtsus ; Tinane vihm ; Öö segadus ; Meister ja õpilane ; Sealpool piiri ; Hõbehall ; Arusaamatu pilt ; Reekviem ühele naisele. Andmeid autori kohta lk. 7-8

  5. Animafilm mõistmisest ja tolerantsist jõuab Kuressaarde / Ene Kallas

    Index Scriptorium Estoniae

    Kallas, Ene

    2008-01-01

    Kuressaarde jõuab koos ajaloolase David Vseviovi sissejuhatava loenguga animadraama "Persepolis" : režissöörid Marjane Satrapi (oma koomiksi järgi) ja Vincent Paronnaud : Prantsusmaa - Ameerika Ühendriigid - Iraan 2007

  6. Thiol-ene crosslinking polyamidoamine dendrimer-hyaluronic acid hydrogel system for biomedical applications.

    Science.gov (United States)

    Bi, Xiangdong; Liang, Aiye; Tan, Yu; Maturavongsadit, Panita; Higginbothem, Ashley; Gado, Togor; Gramling, Abigail; Bahn, Hanna; Wang, Qian

    2016-01-01

    A series of alkene functionalized polyamidoamine (PAMAM) dendrimers were synthesized to prepare in situ forming hydrogels with varied gelation time and mechanical properties through crosslinking with thiolated hyaluronic acid (HS-HA). By varying the alkenyl groups on the dendrimers, the gelation time displayed a large range from 8 seconds to 18 hours, and the modulus of the hydrogels ranged from 36 to 183 Pa under experimental conditions. Investigation by (1)H-NMR spectroscopy revealed that the gelation time and the stiffness of the hydrogels were governed by the degree of electron deficiency of alkenyl groups on the dendrimers. This research provided a systematic study on the relationship between chemical structures versus gelation time and mechanical properties of hydrogels, which could guide the way to synthesize in situ forming hydrogels with designated gelation time and stiffness for biomedical applications. Further, a RGD peptide was attached to the PAMAM dendrimers to enhance cell attachment and proliferation. Viability assays of Human Umbilical Vein Endothelial Cells (HUVEC) in the synthesized hydrogels demonstrated the biocompatibility of the hydrogels after 48 hours of culturing, and the RGD peptide improved the viability of HUVEC cells in hydrogels. We believe the PAMAM/HA hydrogel system is a tuneable and biocompatible system for diverse biomedical applications.

  7. How newness enters a country : reception of the "postcolonial" in Estonia / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet, 1968-

    2006-01-01

    Postkolonialistliku tõlkekirjanduse retseptsiooni Eestis vaadeldakse kolme romaani põhjal: Arundhati Roy "Väikeste Asjade Jumal" (eesti k. 1997 ja 2004), Salman Rushdie "Mauri viimane ohe" (eesti k. 2001 ja 2008), Ben Okri "Näljutatud tee" (eesti k. 1998)

  8. Terves kehas terve vaim - a sound mind in a sound body / Ene Kelder

    Index Scriptorium Estoniae

    Kelder, Ene

    2012-01-01

    Pühajärve Haridusseltsi täiskasvanutele suunatud projektist, mille eesmärgiks oli suurendada täiskasvanud õppijate hulka piirkonnas ning praktiseerida aktiivset eluhoiakut ja tervislikke eluviise

  9. Muudatused sisemajanduse koguprodukti arvestustes = Changes in the methodology of macroeconomic statistics / Ene Kaldma

    Index Scriptorium Estoniae

    Kaldma, Ene

    2004-01-01

    2004. aastal tehtud muudatused makromajandusstatistika metoodikas tõid kaasa 1993.-2003. aasta sisemajanduse koguprodukti (SKP) ja selle komponentide suuruse korrigeerimise. Tabel: Sisemajanduse koguprodukt turuhindades kvartalite kaupa enne ja pärast metoodika muutumist, 1993-2003

  10. Novel approaches for using dehydrogenases and ene-reductases for organic synthesis

    NARCIS (Netherlands)

    Gargiulo, S.

    2015-01-01

    Oxidation of alcohols is a reaction of major interest for organic chemistry. However, the most common chemical routes developed so far involve the use of toxic or hazardous reagents or catalysts that often lack good chemoselectivity. In this respect, alcohol dehydrogenases (ADHs) represent a very

  11. Raport : Eesti eramu 2006 - 2007 / Ene Läkk ; interv. Urmas Oja

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2008-01-01

    Eesti Arhitektide Liidu korraldatud konkursist parima eramu tiitlile, žürii koosseis. Väljavalitud töödest koostatakse Arhitektuuri- ja Disainigaleriis näitus "Eramu 2006-2007". Viimaste aastate eramuarhitektuurist, muudatustest ruumiplaneeringus, materjalivalikust

  12. Emotsioonisõnad töises keskkonnas - millest kõnelevad loetelukatsete tulemused? / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene

    2007-01-01

    Emotsioonisõnade esiletulekut tööl ja mujal võrreldakse 2001. aastal läbi viidud loetelukatsetes, tulemuste semantilise analüüsi põhjal tehakse järeldused koha mõju üle emotsioonisõnavarale

  13. 1-(3,5-Dichlorophenyl-3-(2-methoxyphenyltriaz-1-ene

    Directory of Open Access Journals (Sweden)

    Behrouz Notash

    2012-03-01

    Full Text Available The title molecule, C13H11Cl2N3O, is almost planar and adopts a trans conformation with respect to the –N=N– bond; the dihedral angle between the rings is 3.47 (2°. The N—N bond lengths indicate the presence of single- and double-bond characters and hence the –N=N—NH– moiety. In the crystal, inversion dimers linked by pairs of N—H...Cl hydrogen bonds occur, and C—H...π and π–π stacking interactions are also observed.

  14. Learning Organizations. Studiu exploratoriu asupra Consiliilor Judeţene din România

    OpenAIRE

    Diana GHIURA

    2012-01-01

    This article is the result of an ample study centered on the concept of learning organizations, more precisely on the degree in which Romanian County Councils are learning organizations. In order to analyze this, a research instrument has been sent to every County Council. This tool has been developed by three Harvard professors: David A. Garvin, Amy C. Edmondson and Francesca Gino who also published, in 2008, an article in Harvard Business Review ‘Is Yours A Learning Organization?’. Their ar...

  15. Kelle emotsioonile anda teksti ette lugedes hääl? Vaatlus mitmest perspektiivist / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene, 1964-

    2014-01-01

    Püütakse esile tuua, milliste inimloomusest tulenevate tõsiasjadega peab arvestama, kui hakata sünteeskõnele emotsioone matkivat prosoodiat lisama. Koondatud on lähenemised erinevatest teadusharudest

  16. Comparison of photopolymerizable thiol-ene PEG and acrylate-based PEG hydrogels for cartilage development.

    Science.gov (United States)

    Roberts, Justine J; Bryant, Stephanie J

    2013-12-01

    When designing hydrogels for tissue regeneration, differences in polymerization mechanism and network structure have the potential to impact cellular behavior. Poly(ethylene glycol) hydrogels were formed by free-radical photopolymerization of acrylates (chain-growth) or thiol-norbornenes (step-growth) to investigate the impact of hydrogel system (polymerization mechanism and network structure) on the development of engineered tissue. Bovine chondrocytes were encapsulated in hydrogels and cultured under free swelling or dynamic compressive loading. In the acrylate system immediately after encapsulation chondrocytes exhibited high levels of intracellular ROS concomitant with a reduction in hydrogel compressive modulus and higher variability in cell deformation upon compressive strain; findings that were not observed in the thiol-norbornene system. Long-term the quantity of sulfated glycosaminoglycans and total collagen was greater in the acrylate system, but the quality resembled that of hypertrophic cartilage with positive staining for aggrecan, collagens I, II, and X and collagen catabolism. The thiol-norbornene system led to hyaline-like cartilage production especially under mechanical loading with positive staining for aggrecan and collagen II and minimal staining for collagens I and X and collagen catabolism. Findings from this study confirm that the polymerization mechanism and network structure have long-term effects on the quality of engineered cartilage, especially under mechanical loading. Copyright © 2013 Elsevier Ltd. All rights reserved.

  17. Interview; kunst of kliederen; “De ene graffiti is de andere niet”

    NARCIS (Netherlands)

    Keus, R; Vanderveen, G.N.G.

    2010-01-01

    De aanpak van graffiti staat bij veel gemeenten hoog op de agenda. Het tegengaan van overlast en verloedering is hierbij meestal de belangrijkste reden. Maar om een aanpak echt te laten slagen, moet er volgens onderzoekster Gabry Vanderveen eerst goed worden nagegaan welke vormen van graffiti voor

  18. Kinnisvarakorilus Süda tänaval / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2003-01-01

    Kriitiline vaatenurk tunneli rajamise plaanile läbi miljööväärtusliku Tallinna Süda tänava kvartali. Arhitektuuribüroode R-Konsultant ja Koot & Koot pakutavate erinevate lahenduste võrdlus. Arhitektide kommentaare

  19. Punane moon või kaine mõistus / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2001-01-01

    Nukuteatri uue hoone sisekujunduse võistluse I ja II koha töödest. I koha töö autorid Raivo Kotov ja Andrus Kõresaar, II koha töö autorid Ülar Mark, Liina Link, stilist Ain Nurmela ja arvutigraafik Tanel Viks büroost Mark & Tamm Arhitektid

  20. Tööjuhendid algklassi tööõpetuse tundides / Ene Lind

    Index Scriptorium Estoniae

    Lind, Ene

    2001-01-01

    Tekstiga tööst tööõpetuse tunnis, kirjalikust ja suulisest juhendamisest. Tallinna Pedagoogikaülikooli üliõpilaste poolt läbi viidud küsitlusest, milles osalesid 22 klassiõpetajat Tallinnast ja 15 mujalt vabariigist. Kõik pedagoogid andsid oma klassis ka tööõpetuse või käsitöö tunde. Küsitlusega selgitati, milline on tööjuhendite abil korraldatava iseseisva individuaalse töö osatähtsus noorema kooliastme tööõpetuse ja eri õppeainete tundides

  1. Tre tilfaelde af visceral leishmaniasis: det ene hos en HIV-positiv mand

    DEFF Research Database (Denmark)

    Balslev, U; Jonsbo, F; Junge, Jette

    1991-01-01

    Three cases of visceral leishmaniasis (kala-azar) are presented. One of these was in a 43-year-old patient with AIDS who was infected in Southern Spain. Another was in a man aged 25 years infected in West Africa. These cases are the first two adults to be reported in Denmark. The third case was a...

  2. Lean versus Quick Response Manufacturing og andre koncepter - er Lean den eneste ene?

    DEFF Research Database (Denmark)

    Michelsen, Aage U

    2005-01-01

    principper fra andre koncepter? Artiklen er opdelt i fire hovedafsnit. I første afsnit skitseres baggrunden for Lean. I andet afsnit skitseres kort indholdet i Lean. I tredje afsnit skitseres tankegangen bag Quick Response Manufacturing - et begreb, der har mange ligheder med Lean, men som har fokus på......Begrebet Lean har gennem de senere år vundet en enorm udbredelse. Antallet af publikationer om Lean har været eksplosivt stigende, og mange virksomheder har gennemført eller gennemfører Lean-projekter. Er Lean et nyt koncept? Er Lean den eneste løsning? Kan Lean kombineres med tankegange og...... løsning af en anden produktionsopgave. I fjerde afsnit skitseres kort relationerne mellem Lean og to andre begreber, Six Sigma og TPM, der begge har samme mål som Lean, men forskellige udgangspunkter og forskellige indfaldsvinkler....

  3. Riigipeade kokad - Chefs des Chefs / Sirkka Ruottinen, Indrek Kivisalu ; interv. Ene Ojaveski

    Index Scriptorium Estoniae

    Ruottinen, Sirkka

    2006-01-01

    Soome presidendi Tarja Haloneni ja Eesti presidendi Arnold Rüütli peakokad räägivad oma karjäärist presidendi peakoka ametini, kirjeldavad tavalist tööpäeva ja töökeskkonda presidendi köögis, iseloomustavad Soome ja Eesti toidukultuuri ning meenutavad huvitavaid seiku oma ametiajast. Vt. samas: Sirkka Ruottinen vastab küsimustele, mis puudutavad Riigipeade Peakokkade Klubi (Club des Chefs des Chefs) tegevust

  4. Me suudame ajaga kaasas käia / interv. Ene Riet

    Index Scriptorium Estoniae

    2003-01-01

    Eesti raamatukoguhoidjate VIII kongressi (9.-10. juuni 2002) delegaatitelt küsiti arvamust Eesti raamatukogunduse kohta, vastasid: Kalli Kuhi, Sirje Okapuu, Toomas Liivamägi, Sirje Lauring-Vaska, Helve Sreiberg, Irina Kruusla, Ädu Neemre, Tiit Margna, Valentina Brovina, Asko Tamme, Meeli Veskus

  5. Identification of fungal ene-reductase activity by means of a functional screening.

    Science.gov (United States)

    Romagnolo, Alice; Spina, Federica; Brenna, Elisabetta; Crotti, Michele; Parmeggiani, Fabio; Varese, Giovanna Cristina

    2015-06-01

    Bioeconomy stresses the need of green processes promoting the development of new methods for biocatalyzed alkene reductions. A functional screening of 28 fungi belonging to Ascomycota, Basidiomycota, and Zygomycota isolated from different habitats was performed to analyze their capability to reduce C=C double bonds towards three substrates (cyclohexenone, α-methylnitrostyrene, and α-methylcinnamaldehyde) with different electron-withdrawing groups, i.e., ketone, nitro, and aldehyde, respectively. Almost all the fungi showed this reducing activity. Noteworthy Gliomastix masseei, Mucor circinelloides, and Mucor plumbeus resulted versatile and effective, being able to reduce all the model substrates quickly and with high yields. Copyright © 2015 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

  6. Tre tilfaelde af visceral leishmaniasis: det ene hos en HIV-positiv mand

    DEFF Research Database (Denmark)

    Balslev, U; Jonsbo, F; Junge, Jette

    1991-01-01

    Three cases of visceral leishmaniasis (kala-azar) are presented. One of these was in a 43-year-old patient with AIDS who was infected in Southern Spain. Another was in a man aged 25 years infected in West Africa. These cases are the first two adults to be reported in Denmark. The third case...

  7. Lendab nagu kotkas üle maailmas kogutud tarkuse / Richard Aroksaar ; intervjueerinud Ene Riet

    Index Scriptorium Estoniae

    Aroksaar, Richard

    2014-01-01

    Intervjuu eestlase Richard Aroksaarega, kes õppinud psühholoogiat ja raamatukogundust, töötab USA Rahvusparkide Ühenduse raamatukogus (National Park Service Library, NPS) süsteemi raamatukoguhoidja ja administraatorina

  8. Tre tilfaelde af visceral leishmaniasis: det ene hos en HIV-positiv mand

    DEFF Research Database (Denmark)

    Balslev, U; Jonsbo, F; Junge, Jette

    1991-01-01

    Three cases of visceral leishmaniasis (kala-azar) are presented. One of these was in a 43-year-old patient with AIDS who was infected in Southern Spain. Another was in a man aged 25 years infected in West Africa. These cases are the first two adults to be reported in Denmark. The third case was a...... was an 18 month old previously healthy boy, infected in Southern Spain. The symptomtology, diagnosis and treatment of the disease are discussed and it is stressed that serological diagnostic tests have limited value in HIV positive patients.......Three cases of visceral leishmaniasis (kala-azar) are presented. One of these was in a 43-year-old patient with AIDS who was infected in Southern Spain. Another was in a man aged 25 years infected in West Africa. These cases are the first two adults to be reported in Denmark. The third case...

  9. Eesti keele sõnavara afektikalduvus ja mis sellega peale hakata / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene, 1964-

    2012-01-01

    Praktilisest vajadusest väljakasvanud probleemist muuta eestikeelne sünteeskõne loomulikumaks ja emotsionaalselt usutavamaks. Artiklis keskendutakse leksikaalsele tasandile, arutletakse selle üle, millised sõnaklassid on enim emotsioonidega seotud

  10. DRUŽINSKA MEDIACIJA, KO SO OGROŽENE OTROKOVE KORISTI

    OpenAIRE

    Mendaš, Dominika

    2014-01-01

    Družinska mediacija se je v zadnjih letih tudi v Sloveniji uveljavila kot učinkovit način alternativnega reševanja družinskopravnih sporov. Družinski konflikti pogosto vključujejo tudi otroke, katerim moramo ob nenadnih življenjskih spremembah posvetiti posebno pozornost. Vključevanje otrok v mediacijo se je v praksi izkazalo kot pozitiven način, kako usmeriti pozornost udeleženih strank na ključno temo razprave varovanje otrokovih koristi. Mednarodni in nacionalni pravni akti dajejo pravn...

  11. Maja nagu kuupidest küla / Ene Läkk, Helen Urbanik

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Ühepereelamu Maastrichti lähedal. Projekti autorid Ettore Sottsass, Johanna Grawunder, arhitekt Oliver Layseca. Keskse siseõue ümber eraldiseisvaid kuupe ühendavad koridorid. Iga elutegevuse jaoks on omaette tsoon. Uksed peaaegu puuduvad. Sisekujunduses domineerib massiivne ja mahukas mööbel.

  12. Austraalia ilusaim rannikutee sõjaohvrite mälestuseks / Eneli Ivask

    Index Scriptorium Estoniae

    Ivask, Eneli

    2006-01-01

    Vt. ka Delovõje Vedomosti : Vkuss Zhizni 13. sept., lk. 4-5. Austraalia lõunarannikul, mitte kaugel Melbourneist on maailma kauneimaks peetav 400 km pikkune hingematvalt lummavate ja erinäoliste vaadetega rannikutee - Great Ocean Road

  13. Tootedisaineri töö peenmehaanika ja olemise jaatus / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2011-01-01

    Tootjate ja riskikapitalistide huvist tootedisaineri teenuse vastu. Eesti disainibüroodest MaDis-Stuudio (Matti Õunapuu), Ten Twelve (asutaja: Jukka Halttunen), Keha3 (Margus Triibmann, Tarmo Luisk, Pavel Sidorenko, juht: Ville Jehe) ja Iseasi (Martin Pärn, Sven Sõrmus, Edina Dufala-Pärn, Pent Talvet, Kaspar Torn), pakutavatest teenustest ja töödest

  14. "Ostanovimsja na mig v tishine..." : [luuletused] / Ene Mihkelson ; lühibiograafia: T. L. [Toomas Liiv

    Index Scriptorium Estoniae

    Mihkelson, Ene, 1944-2017-

    1999-01-01

    Sisu: "Ostanovimsja na mig v tishine..." / tlk. V. Fadin ; Rekviem / tlk. Marju Lauristin ; "Dom eto tolko godõ..." ; "Dvoje bezumtsev mezh nimi treti..." ; "Eva v Tapa zhivjot / tlk. Boris Tuch ; "Ljagushka prõgnula skvoz lezvije kossõ..." ; "Vse stantsii peremeshtshalis..." ; "Dõb iz trub stekajet..." ; "Vremja neuklonno i surovo..." / tlk. M. Korol ; Pjat tshassov kogda snega net / tlk. Jelena Salkova. Orig.: Reekviem ; "Konn hüppas vikatist läbi..." ; "Kõik jaamad segunesid Valisime keeli..." ; "Suits sajab korstnaist maha..." ; "Aeg on karm ja ühepoolne Meid..."; Kell viis kui pole lund

  15. Ida-Virumaa rahvakultuuri mänguline muusa - Meeri Amanda / Ene Raudar

    Index Scriptorium Estoniae

    Raudar, Ene

    2015-01-01

    Ida-Virumaa kultuuritöötajate ühisest aktsioonist 2014. a. 26. okt. - kultuuri killavoor Aserist Avinurme, et Eesti Pärandkultuuri aastal pöörata rohkem tähelepanu väikestele rahvamajadele, kus igapäevast rahvakultuuri elus hoitaksegi

  16. Kui tuulispasa poolt pühitud / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    1998-01-01

    Nõmme keskuses asunud kultuurimälestiseks tunnistatud tornist, mille kevadel lammutas Tallinna Elektrivõrk. Muinsuskaitseinspektsioon nõuab torni taastamist. AS 'Vunder' kavatses sinna rajada kunstigalerii, sidudes torni uusehitisega. Arhitekt Margus Koot arhitektuuribüroost Koot ja Koot. Kommenteerivad Maret Järv Nõmme linnaosavalitsusest, Margus Koot, Andri Ksenofontov jt.

  17. Vene kinopravdast sai prantsuse cinema-verite / Ronald Bergan ; tõlk. Ene Jürna

    Index Scriptorium Estoniae

    Bergan, Ronald

    2004-01-01

    FIPRESCI asepresident meenutab 18. veebruaril 2004.a. surnud prantsuse dokumentalistika suurkuju Jean Rouchi (sünd. 31.05.1917). Lisatud Jaan Ruusi kommentaar Rouchi sidemetest Eesti kineastide Mark Soosaare ja Vladimir Karassev-Orgussaarega

  18. UGROŽENE VRSTE RIBA U SVIJETU: Aphanius farsicus Teimori, Esmaeili i Reichenbacher, 2011 (Cyprinodontidae)

    OpenAIRE

    KEIVANY, Yazdan; Reza Esmaeili, Hamid

    2013-01-01

    Vrsta šaranozupke Aphanius farsicus Teimori (Esmaeili i Reichenbacher, 2011) iz porodice Cyprinodontidae ili endemična farska vrsta nekoć je bila česta u slivu jezera Maharloo, a danas nestaje iz autohtonog staništa. Ova vrsta šaranozupke još se ne nalazi na popisu IUCN-ove Crvene knjige ugroženih vrsta, iako zadovoljava sve kriterije za svrstavanje na spomenuti popis – ograničena joj je distribucija, mrijestilišna područja se razaraju, zagađuje se okoliš i javlja se suša. Ova osjetljiva vrst...

  19. Tammsaare, Kangro ja Vanapagan / Ilse Lehiste ; inglise k. tlk. Ene-Reet Soovik

    Index Scriptorium Estoniae

    Lehiste, Ilse, 1922-2010

    2000-01-01

    Orig.: Tammsaare, Kangro and the Devil. Varem ilmunud: Baltic Literature and Linguistics. Ohio : Association for the Advancement of Baltic Studies, 1973. A. H. Tammsaare romaanist "Põrgupõhja uus Vanapagan" (1939) ning Bernard Kangro romaanist "Taeva võtmed" (1956)

  20. Kriisimissioonidel ei anta üksnes abi, seal õpitakse palju ka ise / Ene Pajula

    Index Scriptorium Estoniae

    Pajula, Ene, 1950-

    2010-01-01

    Lääne-Tallinna keskhaigla kirurgia- ja anestesioloogiakliiniku juhataja, anestesioloog Jaak Talving on üks Eesti kümmekonnast päästemeedikuks koolitatud arstist. Ta on käinud missioonil Indoneesias ja Haitil ning aidanud sisustada Afganistani väikehaiglat

  1. 1-[(Z-1-Bromo-2-(butyldichloro-λ4-tellanylethenyl]cyclohex-1-ene

    Directory of Open Access Journals (Sweden)

    Julio Zukerman-Schpector

    2011-07-01

    Full Text Available The TeIV atom in the title compound, [Te(C4H9(C8H10BrCl2] or C12H19BrCl2Te, is in a distorted ψ-trigonal–bipyramidal geometry, with the lone pair of electrons projected to occupy a position in the equatorial plane, and with the Cl atoms being mutually trans [172.48 (4°]. Close intramolecular [Te...Br = 3.3444 (18 Å] and intermolecular [Te...Cl = 3.675 (3 Å] interactions are observed. The latter lead to centrosymmetric dimers which assemble into layers in the bc plane. The primary connections between layers are of the type C—H...Cl.

  2. Tre tilfaelde af visceral leishmaniasis: det ene hos en HIV-positiv mand

    DEFF Research Database (Denmark)

    Balslev, U; Jonsbo, F; Junge, Jette

    1991-01-01

    Three cases of visceral leishmaniasis (kala-azar) are presented. One of these was in a 43-year-old patient with AIDS who was infected in Southern Spain. Another was in a man aged 25 years infected in West Africa. These cases are the first two adults to be reported in Denmark. The third case...... was an 18 month old previously healthy boy, infected in Southern Spain. The symptomtology, diagnosis and treatment of the disease are discussed and it is stressed that serological diagnostic tests have limited value in HIV positive patients....

  3. Otsusta Eesti Tulevik / Arnold Rüütel, Ene Ergma, Juhan Parts

    Index Scriptorium Estoniae

    Rüütel, Arnold

    2003-01-01

    Ilmunud ka Valgamaalane (2003/Jun/28) lk. 2 ; Sakala (2003/Jun/27) lk. 2 ; Koit (2003/Jun/26) lk. 7 ; Maaleht (2003/Jun/26) lk. 4 ; Põhjarannik (2003/Jun/26) lk. 2 ; Severnoje Poberezhje (2003/Jun/26) lk. 2 ; Vooremaa (2003/Jun/26) lk. 1 ; Vaba Eesti Sõna (2003/Jul/2) lk. 3 ; Tribüün : Euroopa Liidu rahvahääletuse eri (2003/Aug/15) lk. 3. Vabariigi Presidendi, Riigikogu esimehe ja peaministri ühisavalduse tekst

  4. Interviewer behaviour during oral proficiency interviews : a gender perspective / Edith Reemann, Ene Alas, Suliko Liiv

    Index Scriptorium Estoniae

    Reemann, Edith

    2013-01-01

    Analüüsitakse intervjueerija käitumise soolisi iseärasusi inglise keele riigieksami suulise keelepädevustesti läbiviimisel, kas on olemas ühele või teisele sugupoolele omaseid käitumismalle ning kas need võiksid mõjutada intervjueeritavat oma oskuste demonstreerimisel

  5. Artur Lemba - tunglakandja : Ühe suurmehe metaelulugu / Ene Metsjärv ; intervjueerinud Marju Riisikamp

    Index Scriptorium Estoniae

    Metsjärv, Ene, 1943-

    2014-01-01

    Pianist, helilooja ja pedagoog Artur Lemba elust ja loometööst. A. Lemba õpilaste Veera Lensini, Salme Lohuaru (kuni 1950 Andre), Valentine Riivese, Tiiu Targamaa, Villem Reimanni ja Elsa Avessoni ülestähendusi oma õpetajast

  6. Emotsioonid eesti keele käeväljendites / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene, 1964-

    2010-01-01

    Analüüsitakse eesti keele kõnelejate konventsionaalseid teadmisi ja ettekujutusi suhtlusprotsessist, uurides lähemalt leksikaalseid väljendeid, mille üheks komponendiks on viide käele (või selle osale)

  7. Dollar$ & $en$e. Part IV: Measuring the value of people, structural, and customer capital.

    Science.gov (United States)

    Wilkinson, I

    2001-01-01

    In Part I of this series, I introduced the concept of memes (1). Memes are ideas or concepts, the information world equivalent of genes. The goal of this series of articles is to infect you with my memes, so that you will assimilate, translate, and express them. We discovered that no matter what our area of expertise or "-ology," we all are in the information business. Our goal is to be in the wisdom business. We saw that when we convert raw data into wisdom we are moving along a value chain. Each step in the chain adds a different amount of value to the final product: timely, relevant, accurate, and precise knowledge which can then be applied to create the ultimate product in the value chain: wisdom. In Part II of this series, I infected you with a set of memes for measuring the cost of adding value (2). In Part III of this series, I infected you with a new set of memes for measuring the added value of knowledge, i.e., intellectual capital (3). In Part IV of this series, I will infect you with memes for measuring the value of people, structural, and customer capital.

  8. Maakondliku Liivide etluskonkursi võitis gümnasist Marian Heinat / Ene Kallas

    Index Scriptorium Estoniae

    Kallas, Ene

    2008-01-01

    Maakondliku Juhan ja Jakob Liivi etluskonkursi žüriisse kuulusid Ott Aardam, Käthe Pihlak, Piret Rauk, Vaido Luks ja Marili Pärtel. Grand prix' võitis Marian Heimat, laureaatideks tulid Liisa Saaremäel, Maria Pihlak ja Laura Oolup. Eripreemiad said Marii Metsmaa, Ermo Loik, Sander Aavik, Kaimar Nuut ja Priidu Aardam

  9. Asutamisvabadus Euroopa Ühenduse õiguses : kohaldatavus ladina notariaadile / Ene Andresen

    Index Scriptorium Estoniae

    Andresen, Ene, 1977-

    1999-01-01

    Euroopa Ühenduse asutamislepingu kohaldatavusest notariametile, "avaliku võimu teostamise" mõistest ning vastavatest Euroopa Kohtu lahenditest, Eesti notariaaltoimingute vastavusest Euroopa Ühenduse asutamislepingule ning üksikute tegevuste eraldatavuse probleemist

  10. Disainer Maile Grünberg üllatab taas / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2011-01-01

    Maile Grünbergi poolt kujundatud kasevineerist mööbliseeria "Veneer MG" Tallinnas Arhitektuuri ja Disainigaleriis 24.11.-14.12.2011. Kaubamärk "Veneer MG" sündis koostöös ettevõttega Aja Nägu OÜ. Mööbel on mõeldud seeriatootmiseks

  11. Solvent Effects in Asymmetric Hetero Diels-Alder and Ene Reactions

    DEFF Research Database (Denmark)

    Johannsen, Mogens; Jørgensen, Karl Anker

    1996-01-01

    The use of polar solvents such as nitromethane or 2-nitropropane leads to a significant improvement of the catalytic properties of a cationic copper-Lewis acid in the hetero Diels-Alder reaction of alkyl glyoxylates with dienes; The scope of a newly developed copper(II)-bisoxazoline catalyst...... for the hetero Diels-Alder reaction is demonstrated by the reaction of different dienes with alkyl glyoxylates in nitroalkane solvents with the formation of the hetero Diels-Alder adduct in high enantiomeric excess as the major product. The synthetic application of the reaction is exemplified by an improved...

  12. Learning Organizations. Studiu exploratoriu asupra Consiliilor Judeţene din România

    Directory of Open Access Journals (Sweden)

    Diana GHIURA

    2012-12-01

    Full Text Available This article is the result of an ample study centered on the concept of learning organizations, more precisely on the degree in which Romanian County Councils are learning organizations. In order to analyze this, a research instrument has been sent to every County Council. This tool has been developed by three Harvard professors: David A. Garvin, Amy C. Edmondson and Francesca Gino who also published, in 2008, an article in Harvard Business Review ‘Is Yours A Learning Organization?’. Their article is fundamental for this study. Approximately 26 out of 41 County Councils participated to the study and the findings are summarized in this article. The results were really interesting and according to them, Romanian County Councils are learning organizations only in terms of leadership that encourages learning. Regarding the other two blocks – learning environment and learning processes, the findings revealed that the County Councils act like learning organizations in a very small degree. As a consequence, the organizations that participated to the study still have many things to improve in order to become learning organizations.

  13. "Juu Jääb" 2009 džässisaarel / Ene Kallas

    Index Scriptorium Estoniae

    Kallas, Ene

    2009-01-01

    Kolmeteistkümnenda tulevikumuusika festivali "Juu Jääb" (peakorraldaja Villu Veski) üritustest Muhu saarel, Vormsil ja Kuressaares. Muhus Nautse külas Mihkli talus toimunud kontsertidest, kus esinesid saksa lauljanna Pascal von Wroblewsky, USA ansambel Napoleon Maddox Quartet, saksofonist Lembit Saarsalu koos Trio X-ga, Ivo Linna koos Olav Ehala, Toivo Undi ja Kaspar Kallustega

  14. Courants du Monde'i programmi toel Prantsusmaal / Asko Tamme ; intervjueerinud Ene Riet

    Index Scriptorium Estoniae

    Tamme, Asko

    2010-01-01

    Intervjuu Tartu Linnaraamatukogu direktori Asko Tammega, kes käis tutvumas Prantsusmaa raamatukogudega, sh Pompidou keskuse raamatukoguga, Rennes'i keskraamatukoguga ning Raamatu ja Lugemise Bretagne'i keskusega (Livre et Lecture en Bretagne)

  15. Intramolecular butenolide allene photocycloadditions and ensuing retro-ene reactions of some photoadducts

    NARCIS (Netherlands)

    Lutteke, G.; Kleinnijenhuis, R.A.; Jacobs, I.; Wrigstedt, P.J.; Correia, A.C.A.; Nieuwenhuizen, R.; Hue, B.T.B.; Goubitz, K.; Peschar, R.; van Maarseveen, J.H.; Hiemstra, H.

    2011-01-01

    This report describes intramolecular [2+2] photocycloadditions of several butenolides with an allenylmethyl substituent at the 5-position. These photosubstrates were prepared from 2-(silyloxy)furans through silver-mediated reactions with allenylmethyl bromides. Two cases were studied where the

  16. The role of trust in business relations in Estonia / Urve Venesaar, Ene Kolbre

    Index Scriptorium Estoniae

    Venesaar, Urve, 1944-

    2004-01-01

    Ärisuhete analüüsi tulemustest lähtuvalt järeldavad autorid, et Eesti ettevõtjad ei ole koondanud oma ärisuhted ainult isiklikule, vaid ka kollektiivsele ja institutsionaalsele usaldusele, mida on mõjutanud ettevõtete kohanemise vajadus tänaseks välja kujunenud Eesti ärikeskkonnas. Tabelid

  17. Mida teevad mõtted, kui nad "mõlguvad"? / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene, 1964-

    2013-01-01

    Kognitiivsest semantikast, eriti kehapõhisuse teooriast lähtudes, uuritakse, milline kehaline kogemus on motiveerinud sõna "mõlkuma" kasutuselevõtmist perioodilisi mõtteprotsesse tähistava verbina

  18. Päevad on laused : [luulekava] / Ene Mihkelson ; koost. Arne Merilai

    Index Scriptorium Estoniae

    Mihkelson, Ene, 1944-2017-

    2005-01-01

    Sisu: "Ühel väga pimedal väga lagedal väljal kus must taevas..." ; "Luuletaja elas pimedas toas ja ootas nägemusi..." ; "Ma lähen ma tulen ma olen ma seisan alati paigal..." ; "Miks meeldib mulle tetraeeder just karjamaal..." ; "Igavene on ilmaköis..." ; "Elu ongi jumalagajätt väljamõeldud..." ; "Kui olin saanud neljaseks Nii väga kiitis..." ; "Meid oli üks tüdruk Me rääkisime..." ; "Olin kaua endaga ma isekeskis õppisin..." ; "Varemed ei põle need vajuvad mulda..." ; "Juustes kasvab valgus..." ; "Küll tahaks vabaneda valeluulest..." ; "Ta armastus on surm..." ; "Minult on küsitud, kas ma saan keerulisemalt ja ma olen öelnud..." ; "Ta haridus oli lünklik, omandatud peamiselt iseõppimise..." ; "Valge kala ujub läbi metsa..." ; "Sinagi kuuled vist kuidas..." ; "Raual on raua kõla..." ; "Need köied ripuvad..." ; "Ärkasin kolmekümne seitsme aastasena..." ; "Üksteise sisse on minek asjadel ja elul..." ; "Mitte metsade vahelt vaid põldude äärest..." ; "Hämarusest tulevad ja hämarusse lähevad näod..." ; "Ta jutustas, mida nägi, ja see oli nii, nagu oleksid kõik..." ; "Mu päevatöö on read mu päevatöö on vari..." ; "Minevik on müüa..." ; "Üks kauge küla tappis ennast ise..." ; "Suur must auk on küla sees..." ; "Rooste on rahulik Rooste..." ; "Mees kes pianisti sõrmeluid ükshaaval murdnud..." ; "Kellele tema oma hinge müüs..." ; "Tuletan sulle meelde et oleme palju..." ; "Sest tema oli barbar mitte päritolu tõttu, vabast tahtest..." ; "Kui veel reagi kirjutad..." ; "Sügavale on taevas mind matnud..." ; "Kes ta siis ikkagi oli: inimene eikuskilt, miks ta ei..." ; "Me läheme ürgsele maale seal pilvede kodu..." ; "Kannan sõelaga aega..." ; "Jumal sina oled näinud mu kujutluste..." ; "Tõstsin kivi mille all elas vähk..." ; "See hingelõpp see võppumine..." ; "Risti alla pandi sinu keha..." ; "Igal ajal ööl on musta värvi..." ; "Vahest elaski kord mees kelle..." ; "Vast ainult üks meil on see päris hull..." ; "Arturi kollased silmad..." ; "Lumi on katnud kinni varemed ja kuusehekk kasvanud..." ; "Kord jäävad ainult jooned ajalukku..." ; "Meie kirjutame luuletusi hõredale õhule..." ; "Ammutamatu on õhtu mil läheme koju..." ; "Väike poiss igavesti narmendavas palitus..." ; "Aadu oli mu klassivend..." ; Kell viis kui pole lund

  19. 78 FR 717 - ENE (Environment Northeast); Greater Boston Real Estate Board; National Consumer Law Center...

    Science.gov (United States)

    2013-01-04

    ... Consumer Law Center; NEPOOL Industrial Customer Coalition; v. Bangor Hydro-Electric Company; Central Maine Power Company; New England Power Company; New Hampshire Transmission LLC; NSTAR Electric Company; Northeast Utilities Service Company; The United Illuminating Company; Unitil Energy Systems, Inc.; Fitchburg...

  20. Collective memory and the politics of experience in Estonian post-Soviet life stories / Ene Kõresaar

    Index Scriptorium Estoniae

    Kõresaar, Ene, 1971-

    2005-01-01

    Elulugude põimumine kultuuritraditsioonide ja suulise traditsiooniga ning nende jutustamine kui poliitilise ajaloo väljendusvorm. Kollektiivse mälu ja poliitika vahelistest seostest kahe Eesti Kultuuriloolisele Arhiivile saadetud Eesti nõukogude aega kajastava eluloo alusel