WorldWideScience

Sample records for ene kolbre angelika

  1. Noorteprogramm "Angelika! Angelika!" / Helemall Piirfeldt

    Index Scriptorium Estoniae

    Piirfeldt, Helemall

    2005-01-01

    2005. a. mais Kadrioru Kunstimuuseumis näituse "Šveitsi muusa. Angelika Kauffmann (1741-1807)" raames toimunud noorteprogrammist "Angelika! Angelika!", mida juhendasid moekunstnik Sirje Märjamaa ja muuseumipedagoog Helemall Piirfeldt. Moeetenduse lavastas Tiina Makarov, konsultant oli grimmikunstnik Anu Konze

  2. The role of trust in business relations in Estonia / Urve Venesaar, Ene Kolbre

    Index Scriptorium Estoniae

    Venesaar, Urve, 1944-

    2004-01-01

    Ärisuhete analüüsi tulemustest lähtuvalt järeldavad autorid, et Eesti ettevõtjad ei ole koondanud oma ärisuhted ainult isiklikule, vaid ka kollektiivsele ja institutsionaalsele usaldusele, mida on mõjutanud ettevõtete kohanemise vajadus tänaseks välja kujunenud Eesti ärikeskkonnas. Tabelid

  3. Angelika Epple, Angelika Schaser (Hg.: Gendering Historiography. Beyond National Canons. Frankfurt am Main u.a.: Campus Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Svenja Kaduk

    2010-03-01

    Full Text Available Der Sammelband von Angelika Epple und Angelika Schaser bietet sowohl einen internationalen Überblick als auch detaillierte Einblicke in derzeitige geschlechtergeschichtliche und historiografische Forschungen. Die Beiträge erweitern zum einen den traditionellen historiografischen Kanon und fragen zum anderen nach den geschlechtlichen Grundlagen von In- und Exklusionen in der Geschichtswissenschaft. Dieser Wissenszuwachs treibt aber die nunmehr schon traditionell seitens der Geschlechtergeschichte geforderte Neuformulierung der ‚allgemeinen‘ (Historiografie-Geschichte nicht merklich voran. Ein erster Schritt in diese Richtung läge möglicherweise in der Formulierung einer Differenztheorie als analytischem Rahmen für eine pluralistische ‚Neu‘erzählung.The collected volume edited by Angelika Epple and Angelika Schaser offers an international overview of as well as detailed insight into current gender-historical and historiographic research. On the one hand, the contributions expand on the traditional historiographic canon and interrogate, on the other hand, the gender-based decisions for inclusion and exclusion in history scholarship. But this growth in knowledge does not significantly promote the demand for a reformulation of “general” (historiography-history, which can already be considered traditional in terms of gender history. A first step in this direction might be possible through the formulation of a theory of difference, which can become an analytical framework for a pluralistic “new” narrative.

  4. Rezension zu: Angelika Epple, Angelika Schaser (Hg.: Gendering Historiography. Beyond National Canons. Frankfurt am Main u.a.: Campus Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Svenja Kaduk

    2010-01-01

    Full Text Available Der Sammelband von Angelika Epple und Angelika Schaser bietet sowohl einen internationalen Überblick als auch detaillierte Einblicke in derzeitige geschlechtergeschichtliche und historiografische Forschungen. Die Beiträge erweitern zum einen den traditionellen historiografischen Kanon und fragen zum anderen nach den geschlechtlichen Grundlagen von In- und Exklusionen in der Geschichtswissenschaft. Dieser Wissenszuwachs treibt aber die nunmehr schon traditionell seitens der Geschlechtergeschichte geforderte Neuformulierung der ‚allgemeinen‘ (Historiografie-Geschichte nicht merklich voran. Ein erster Schritt in diese Richtung läge möglicherweise in der Formulierung einer Differenztheorie als analytischem Rahmen für eine pluralistische ‚Neu‘erzählung.

  5. E-poliitika ärikeskkonna kujundajana : kaubanduse ja kinnisvaraturu näitel / Ene Kolbre, Urve Venesaar

    Index Scriptorium Estoniae

    Kolbre, Ene, 1946-

    2003-01-01

    Ülevaade infotehnoloogia kasutamise tingimustest äris üldiselt, veidi põhjalikumalt internetikaubanduses ja kinnisvaraturul, toetudes kirjanduse, Eesti ärikeskkonna ja e-poliitika arengu analüüsile

  6. Ettevõtte strateegia ja kinnisvara väärtus / Veronika Ilsjan, Ene Kolbre, Signe Liiv

    Index Scriptorium Estoniae

    Ilsjan, Veronika

    2003-01-01

    Ettevõtte strateegia ja kinnisvarastrateegia ühendamine on kahesuunaline protsess - ettevõtte strateegia peab sisaldama kinnisvaraga arvestamist ja kinnisvara juhtimine lähtuma ettevõtte strateegiast. Tabel. Joonis

  7. Microbial synthesis of alka(enes

    Directory of Open Access Journals (Sweden)

    Weihua eWang

    2013-10-01

    Full Text Available Alka(enes are the predominant constituents of gasoline, diesel, and jet fuels. They can be produced naturally by a wide range of microorganisms. Bio- alka(enes can be used as drop-in biofuels. To date, five microbial pathways that convert free fatty acids or fatty acid derivatives into alka(enes have been identified or reconstituted. The discoveries open a door to achieve microbial production of alka(enes with high efficiency. The modules derived from these alka(ene biosynthetic pathways can be assembled as biological parts and synthetic biology strategies can be employed to optimize the metabolic pathways and improve alka(ene production.

  8. Ene Sepp esitles esikteost "Medaljon" / Heli Talinurm

    Index Scriptorium Estoniae

    Talinurm, Heli

    2009-01-01

    Ene Sepp esitles 19. veebruaril Rapla Keskraamatukogus oma raamatut, mis pälvis kolmanda koha Eesti Lastekirjanduse Teabekeskuse ja kirjastuse Tänapäev 2008. aasta noorsooromaani võistlusel. Ly Ehini mõtteid, mida Ene Sepa raamat temas tekitas

  9. [Bewusstes Erinnern und bewusstes Vergessen : der juristische Umgang mit der Vergangenheit in den Ländern Mittel- und Osteuropas / hrsg. v. Angelika Nußberger, Caroline von Gall. (Jus Internationale et Europaeum ; 52). Mohr Siebeck, Tübingen 2011.

    Index Scriptorium Estoniae

    Luts-Sootak, Marju, 1966-

    2014-01-01

    Arvustus: Bewusstes Erinnern und bewusstes Vergessen : der juristische Umgang mit der Vergangenheit in den Ländern Mittel- und Osteuropas / hrsg. v. Angelika Nußberger, Caroline von Gall (Jus Internationale et Europaeum ; 52). Mohr Siebeck, Tübingen 2011. 400 S.

  10. ENES the European Network for Earth System modelling and its infrastructure projects IS-ENES

    Science.gov (United States)

    Guglielmo, Francesca; Joussaume, Sylvie; Parinet, Marie

    2016-04-01

    The scientific community working on climate modelling is organized within the European Network for Earth System modelling (ENES). In the past decade, several European university departments, research centres, meteorological services, computer centres, and industrial partners engaged in the creation of ENES with the purpose of working together and cooperating towards the further development of the network, by signing a Memorandum of Understanding. As of 2015, the consortium counts 47 partners. The climate modelling community, and thus ENES, faces challenges which are both science-driven, i.e. analysing of the full complexity of the Earth System to improve our understanding and prediction of climate changes, and have multi-faceted societal implications, as a better representation of climate change on regional scales leads to improved understanding and prediction of impacts and to the development and provision of climate services. ENES, promoting and endorsing projects and initiatives, helps in developing and evaluating of state-of-the-art climate and Earth system models, facilitates model inter-comparison studies, encourages exchanges of software and model results, and fosters the use of high performance computing facilities dedicated to high-resolution multi-model experiments. ENES brings together public and private partners, integrates countries underrepresented in climate modelling studies, and reaches out to different user communities, thus enhancing European expertise and competitiveness. In this need of sophisticated models, world-class, high-performance computers, and state-of-the-art software solutions to make efficient use of models, data and hardware, a key role is played by the constitution and maintenance of a solid infrastructure, developing and providing services to the different user communities. ENES has investigated the infrastructural needs and has received funding from the EU FP7 program for the IS-ENES (InfraStructure for ENES) phase I and II

  11. Kandidaadid : Ene Ergma versus Toomas Hendrik Ilves

    Index Scriptorium Estoniae

    2006-01-01

    Artiklis vastatakse küsimustele, kes oleksid Kadriorus Ene Ergma ja Toomas Hendrik Ilvese nõunikud, millist sõnumit kannaks nende esimene iseseisvuspäeva kõne, kuidas nad tähistaksid oma võitu presidendivalimistel, kellele nad annaksid Maarjamaa Risti, kuhu nad teeksid oma esimese välisvisiidi

  12. Ene Käpp ali optimizem

    Directory of Open Access Journals (Sweden)

    Dušana Findeisen

    1998-12-01

    Full Text Available Na »Konferenci o vlogi in organizaciji izobraževanja odraslih v času prehoda«, ki je bila novembra lani v Tallinnu, glavnem mestu Estonije, smo srečevali nekaj razsvetljenih obrazov organizatorjev. Med njimi je bila Ene Kapp, kratko pristriženih las, živahnega videza in prodornega glasu. Ene Kapp je neprestano bedela nad nami. Tisti, ki so povezani z estonskim izobraževanjem odraslih, jo poznajo že dolgo. Srečujejo se z njo na ANDRAS-u, estonskem združenju za izobraževanje odraslih.

  13. IS-ENES project management - lessons learnt

    Science.gov (United States)

    Parinet, Marie; Guglielmo, Francesca; Joussaume, Sylvie

    2017-04-01

    IS-ENES is the distributed e-infrastructure of models, model data and metadata of the European Network for Earth System Modelling (ENES). It has benefitted from two EC FP7 grants and aims towards further European and national funding to achieve sustainability. We highlight here several challenges related to project management that have risen in the course of these two project-phases spanning 8 years. Some challenges are related to the heterogeneity of the activities within IS-ENES, with different groups working on very diverse activities, not necessarily strictly interdependent. An immediate consequence is the need of implementing and setting up in early phases of the project efficient collection and circulation of information to preserve and reinforce the systemic view of the infrastructure as a whole and the pursuit of common goals, including coordinated provision of services. Toward and beyond such common goals, managing IS-ENES, covering both scientific and more strictly management-related aspects, implies a double-paced approach: besides setting up efficient project workflow, there is the need of setting up longer term objectives. This implies, within the project lifetime, to elaborate and implement a coherent organizational (consistent with scientific goals, funding schemes, research and technology landscape) strategy to pursue these goals beyond the project itself. Furthermore, a series of more generic project management challenges will also be listed and can be gathered around 3 main objectives: ease the internal processes in order to optimize the work, anticipate delays and budget issues, and motivate the project teams by ensuring an efficient internal and external communication.

  14. Hydroxylative activity of Aspergillus niger towards androst-4-ene and androst-5-ene steroids.

    Science.gov (United States)

    Świzdor, Alina; Panek, Anna; Milecka-Tronina, Natalia

    2017-10-01

    Aspergillus niger, one of fungal species most frequently used for experimental and industrial-scale biotransformations of various organic compounds, is generally known to transform steroids at 16β position. In this work, application of the strain A. niger KCH910 to bioconversion of dehydroepiandrosterone (DHEA), androstenediol and testosterone is described, with emphasis on the metabolic steps leading to the products. Evidence from this study indicated that incubated 5-ene steroids underwent bioconversion within two metabolic pathways: oxidation by the action of 3β-HSD (3β-hydroxysteroid dehydrogenase) to 4-ene steroids, and minor allylic hydroxylation to epimeric 7-alcohols. Further transformation of the 3-oxo-4-ene metabolites resulted in non-selective 16-hydroxylation. It is the first report on an A. niger strain able to introduce not only 16β- but also 16α-hydroxyl function into steroids. Copyright © 2017. Published by Elsevier Inc.

  15. Hybrid Organic/Inorganic Thiol-ene-Based Photopolymerized Networks

    OpenAIRE

    Schreck, Kathleen M.; Leung, Diana; Bowman, Christopher N.

    2011-01-01

    The thiol-ene reaction serves as a more oxygen tolerant alternative to traditional (meth)acrylate chemistry for forming photopolymerized networks with numerous desirable attributes including energy absorption, optical clarity, and reduced shrinkage stress. However, when utilizing commercially available monomers, many thiol-ene networks also exhibit decreases in properties such as glass transition temperature (Tg) and crosslink density. In this study, hybrid organic/inorganic thiol-ene resins ...

  16. Sa uurisid ekspressionismi 1960ndatel ja 70ndatel... / Ene Lamp

    Index Scriptorium Estoniae

    Lamp, Ene

    2005-01-01

    2004. a. ilmunud raamatu "Ekspressionism" eest Eesti Kultuurkapitali suure kunstipreemia (100000 kr.) saanud Ene Lamp ekspressionismi tähenduse muutumiset, ekspressionismi rollist eesti kunstis, oma tulevikuplaanidest

  17. Zukunft der E-Books: Innovationen und Geschäftsmodelle von Verlagen für Medizinbibliotheken an Hochschulen: Je drei Fragen von Bruno Bauer an Klaus Bahmann (Springer, Peter Gemmel (Thieme und Angelika Lex (Elsevier / The future of e-books: innovations and business plan of publishers for medical libraries at universities: 3 questions to Klaus Bahmann (Springer, Peter Gemmel (Thieme and Angelika Lex (Elsevier by Bruno Bauer

    Directory of Open Access Journals (Sweden)

    Lex, Angelika

    2010-05-01

    Full Text Available In the past years electronic books were booming at scientific libraries. E-books have established especially at medical libraries as an important part of the document supply in particular for students.The current interview with Klaus Bahmann (Springer, Peter Gemmel (Thieme and Angelika Lex (Elsevier informs about development, situation and outlook of e-books of three big scientific publishers. They spoke about the focal points in the supply and the diverse business models and the different estimation for the future development of electronic books.

  18. Synthesis of some 16,17-secoandrost-5-ene derivatives

    Directory of Open Access Journals (Sweden)

    Gaković Andrea R.

    2010-01-01

    Full Text Available Starting from 3β-acetoxy-17-oxo-16,17-secoandrost-5-ene-16-nitrile (1, 3β-acetoxy-16,17-secoandrost-5-ene-16-nitrile (4 was synthesized by a three-stage procedure. First, the formyl group of compound 1 was reduced, to yield the alcohol 2. Compound 2 was further transformed to the mesyloxy derivative 3, whose reduction with NaBH3CN gave compound 4. Apart from compound 4 as the main reaction product, two additional products were obtained, for which the GC/MS analysis suggested that they are 8(14 and 14 derivatives of compound 4. Compound 4 was transformed into 3β-hydroxy-16,17-sesoandrost-5-ene-16-nitrile (7, the Oppenauer oxidation of which afforded 3-oxo-16,17-secoandrost-4-ene-16-nitrile (8.

  19. An academic with ambition / Ene Ergma ; interv. Kadri Kukk

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2006-01-01

    Intervjuus Riigikogu asespiikriga käsitletakse kõrghariduse korraldust, professorite rohkust kõrgkoolides, võimalikku kandideerimist Tartu ülikooli rektori kohale, omandatud poliitilisi kogemusi ning ajude äravoolu Eestist. Ene Ergma CV

  20. Tandem Wittig-ene reaction approach to kainic acid

    Digital Repository Service at National Institute of Oceanography (India)

    Majik, M.S.; Parameswaran, P.S.; Tilve, S.G.

    The first example of a tandem Wittig-intramolecular ene reaction approach and its application toward the synthesis of kainic acid is reported. The synthetic pathway involves conversion of prenyl bromide into phosphorane 3, followed by one-pot Wittig...

  1. 5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry.

    Science.gov (United States)

    Kaminskyy, Danylo; Kryshchyshyn, Anna; Lesyk, Roman

    2017-11-10

    The presented review is an attempt to summarize a huge volume of data on 5-ene-4-thiazolidinones being a widely studied class of small molecules used in modern organic and medicinal chemistry. The manuscript covers approaches to the synthesis of 5-ene-4-thiazolidinone derivatives: modification of the C5 position of the basic core; synthesis of the target compounds in the one-pot or multistage reactions or transformation of other related heterocycles. The most prominent pharmacological profiles of 5-ene derivatives of different 4-thiazolidinone subtypes belonging to hit-, lead-compounds, drug-candidates and drugs as well as the most studied targets have been discussed. Currently target compounds (especially 5-en-rhodanines) are assigned as frequent hitters or pan-assay interference compounds (PAINS) within high-throughput screening campaigns. Nevertheless, the crucial impact of the presence/nature of C5 substituent (namely 5-ene) on the pharmacological effects of 5-ene-4-thiazolidinones was confirmed by the numerous listed findings from the original articles. The main directions for active 5-ene-4-thiazolidinones optimization have been shown: i) complication of the fragment in the C5 position; ii) introduction of the substituents in the N3 position (especially fragments with carboxylic group or its derivatives); iii) annealing in complex heterocyclic systems; iv) combination with other pharmacologically attractive fragments within hybrid pharmacophore approach. Moreover, the utilization of 5-ene-4-thiazolidinones in the synthesis of complex compounds with potent pharmacological application is described. The chemical transformations cover mainly the reactions which involve the exocyclic double bond in C5 position of the main core and correspond to the abovementioned direction of the 5-ene-4-thiazolidinone modification. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  2. Fabrication and bonding of thiol-ene-based microfluidic devices

    DEFF Research Database (Denmark)

    Sikanen, Tiina M; Lafleur, Josiane P.; Moilanen, Maria-Elisa

    2013-01-01

    In this work, the bonding strength of microchips fabricated by thiol-ene free-radical polymerization was characterized in detail by varying the monomeric thiol/allyl composition from the stoichiometric ratio (1:1) up to 100% excess of thiol (2:1) or allyl (1:2) functional groups. Four different...... properties for each application. Here, a capillary electrophoresis separation is performed to demonstrate the attractive properties of stoichiometric thiol-ene microchips....

  3. Highly tailorable thiol-ene based emulsion-templated monoliths

    DEFF Research Database (Denmark)

    Lafleur, J. P.; Kutter, J. P.

    2014-01-01

    The attractive surface properties of thiol-ene polymers combined with their ease of processing make them ideal substrates in many bioanalytical applications. We report the synthesis of highly tailorable emulsion-templated porous polymers and beads in microfluidic devices based on off-stoichiometr......The attractive surface properties of thiol-ene polymers combined with their ease of processing make them ideal substrates in many bioanalytical applications. We report the synthesis of highly tailorable emulsion-templated porous polymers and beads in microfluidic devices based on off......-stoichiometry thiolene chemistry. The method allows monolith synthesis and anchoring inside thiol-ene microchannels in a single step. Variations in the monomer stoichiometric ratios and/or amount of porogen used allow for the creation of extremely varied polymer morphologies, from foam-like materials to dense networks...

  4. Thiol-ene/methacrylate systems for mechanical damping

    Science.gov (United States)

    McNair, Olivia; Senyurt, Askim; Wei, Huanyu; Gould, Trent; Piland, Scott; Hoyle, Charles; Savin, Daniel

    2010-03-01

    Ternary thiol-ene-methacrylate (TEMA) networks as materials for mechanical energy damping are unique to the sports world. Using a photoinitiation process, TEMA systems are formed via an initial thiol-ene step-growth mechanism along with traditional radical polymerization of acrylate and ene monomers. Final networks have two-part morphologies: acrylate homopolymer sectors imbedded in a multi-component mesh. Several (TEMA) systems have been synthesized and analyzed via thermal and mechanical probing. Initial studies on these ternary systems have shown excellent properties compared to traditional ethylene vinyl alcohol (EVA) copolymers. For example, PEMA networks exhibit glass transition temperatures 33 K higher than EVA, resulting in improved damping at room temperature. This research will help develop relationships between tan delta, glass transition and their effects on mechanical energy damping for ternary (TEMA) systems.

  5. Surface functionalized thiol-ene waveguides for fluorescence biosensing in microfluidic devices

    DEFF Research Database (Denmark)

    Feidenhans'l, Nikolaj Agentoft; Lafleur, Josiane P.; Jensen, Thomas Glasdam

    2013-01-01

    -ene waveguides were fabricated from 40% excess thiol thiol-ene to ensure the presence of thiol functional groups at the surface of the waveguide. Biotin alkyne was photografted at specific locations using a photomask, directly at the interface between the microfluidic channel and the thiol-ene waveguide prior...

  6. Proof of a conjecture of Colliot-Th\\'el\\`ene

    OpenAIRE

    Denef, Jan

    2011-01-01

    We prove a conjecture of Colliot-Th\\'el\\`ene that implies the Ax-Kochen Theorem on p-adic forms. We obtain it as an easy consequence of a diophantine excision theorem whose proof forms the body of the present paper.

  7. preparation of bicyclic lactones using lewis acids catalyzed ene

    African Journals Online (AJOL)

    Administrator

    The synthesis of the cis-fused bicyclic lactones relies extensively on the Lewis acid ... having an allylic hydrogen (an"ene") and a compound containing an electron .... observed that the lithium enolate obtained from 3-methyl-2(5H)- furanone ...

  8. Ene ja Tõnis Kask pole valikuga rahul / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2003-01-01

    Eesti Filmiajakirjanike Ühing andis auhinna Aasta film 2002 mängufilmile "Agent Sinikael" : režissöör Marko Raat. Viimane sai preemiaks 12 000 krooni. Auhinna rahastajad omanimelise fondi kaudu Eesti Rahvuskultuuri Fondi juures Ene ja Tõnis Kask peavad "Nimed marmortahvlil" väljajätmist isegi nominentide hulgast shokeerivaks

  9. Hybrid Organic/Inorganic Thiol-ene-Based Photopolymerized Networks.

    Science.gov (United States)

    Schreck, Kathleen M; Leung, Diana; Bowman, Christopher N

    2011-09-15

    The thiol-ene reaction serves as a more oxygen tolerant alternative to traditional (meth)acrylate chemistry for forming photopolymerized networks with numerous desirable attributes including energy absorption, optical clarity, and reduced shrinkage stress. However, when utilizing commercially available monomers, many thiol-ene networks also exhibit decreases in properties such as glass transition temperature (T(g)) and crosslink density. In this study, hybrid organic/inorganic thiol-ene resins incorporating silsesquioxane (SSQ) species into the photopolymerized networks were investigated as a route to improve these properties. Thiol- and ene-functionalized SSQs (SH-SSQ and allyl-SSQ, respectively) were synthesized via alkoxysilane hydrolysis/condensation chemistry, using a photopolymerizable monomer [either pentaerythriol tetrakis(3-mercaptopropionate) (PETMP) or 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (TATATO)] as the reaction solvent. The resulting SSQ-containing solutions (SSQ-PETMP and SSQ-TATATO) were characterized, and their incorporation into photopolymerized networks was evaluated.

  10. Fabrication and bonding of thiol-ene-based microfluidic devices

    International Nuclear Information System (INIS)

    Sikanen, Tiina M; Moilanen, Maria-Elisa; Lafleur, Josiane P; Zhuang, Guisheng; Jensen, Thomas G; Kutter, Jörg P

    2013-01-01

    In this work, the bonding strength of microchips fabricated by thiol-ene free-radical polymerization was characterized in detail by varying the monomeric thiol/allyl composition from the stoichiometric ratio (1:1) up to 100% excess of thiol (2:1) or allyl (1:2) functional groups. Four different thiol-ene to thiol-ene bonding combinations were tested by bonding: (i) two stoichiometric layers, (ii) two layers bearing complementary excess of thiols and allyls, (iii) two layers both bearing excess of thiols, or (iv) two layers both bearing excess of allyls. The results showed that the stiffness of the cross-linked polymer plays the most crucial role regarding the bonding strength. The most rigid polymer layers were obtained by using the stoichiometric composition or an excess of allyls, and thus, the bonding combinations (i) and (iv) withstood the highest pressures (up to the cut-off value of 6 bar). On the other hand, excess of thiol monomers yielded more elastic polymer layers and thus decreased the pressure tolerance for bonding combinations (ii) and (iii). By using monomers with more thiol groups (e.g. tetrathiol versus trithiol), a higher cross-linking ratio, and thus, greater stiffness was obtained. Surface characterization by infrared spectroscopy confirmed that the changes in the monomeric thiol/allyl composition were also reflected in the surface chemistry. The flexibility of being able to bond different types of thiol-enes together allows for tuning of the surface chemistry to yield the desired properties for each application. Here, a capillary electrophoresis separation is performed to demonstrate the attractive properties of stoichiometric thiol-ene microchips. (technical note)

  11. 5 küsimust Ene Läkile / Ene Läkk ; interv. Ell-Maaja Randküla

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2006-01-01

    Ene Läkist, kes on alates 2005. aastast interjööri-, disaini- ja arhitektuuriajakirja "Ruum" peatoimetaja. Ene Läkk, Eesti Sisearhitektide Liidu 2005. a. aastapreemia nominent ajakirjandusliku tegevuse eest, ajakirjast "Ruum". Ill.: 6 värv. vaadet, foto ajakirjanikust

  12. Ene-Liiz Semper. Anton Litvin. Bogdan Mamonov

    Index Scriptorium Estoniae

    2005-01-01

    Veebruaris Madridis toimunud Euroopa kunstilaada ARCO jaoks Vene saatkonna galerii poolt koostatud kunstinäitus TRINITY toimub nüüd Tallinnas Vene saatkonna galeriis. Kuraatorid Masha ja Andrei Melnikovid. Osalevad Ene-Liis Semper videoga ArtVideo, vene kunstnik Bogdan Mamonov maaliseeriaga "Ma kanoniseerisin oma sõpru" ja vene kunstnik Anton Litvin fotoprojektiga "Punktuatsioon". Madridis näitas Semper videot "Nimetu"

  13. Multi-chamber and multi-layer thiol-ene microchip for cell culture

    DEFF Research Database (Denmark)

    Tan, H. Y.; Hemmingsen, Mette; Lafleur, Josiane P.

    2014-01-01

    We present a multi-layer and multi-chamber microfluidic chip fabricated using two different thiol-ene mixtures. Sandwiched between the thiol-ene chip layers is a commercially available membrane whose morphology has been altered with coatings of thiol-ene mixtures. Experiments have been conducted ...... with the microchip and shown that the fabricated microchip is suitable for long term cell culture....

  14. ENE-Mates - A public information program for women

    International Nuclear Information System (INIS)

    Nagashima, Kyoko

    1995-01-01

    Japan depends on import for more than 80 percent of its total energy supply. Nuclear energy is one of the most promising alternatives to oil. It plays a significant role for energy supply in terms of reliability, economic viability and reduction of CO 2 emissions. In order to secure needed capacity, the Government concentrates its efforts on acquiring public acceptance of nuclear power as well as ensuring the safety of plants and improving plant capability and reliability. An opinion poll, done by the Japanese Government in Sep. of 1990, showed that 73.3 percent of man and 57.4 percent of women think that nuclear power is necessary to secure energy supply. Nuclear Power Engineering Corporation (NUPEC) employs various methods for information services arid, in particular, electric power generation including nuclear with an assignment from the Japanese Government. Public information activities by the Nuclear Power Engineering Corporation (NUPEC) are as follows: a) Telephone QA service to respond to public inquiries; b) Publishing the 'Nuclear Newsletter' monthly and various brochures; c) Information service by personal computer network Atomnet concerning energy in general, and operation/trouble informations of nuclear plants; d) Distribution and service of personal computers to local governments offices/museums, etc., for users ranging from children to adults to gather nuclear related information; e) Organization of female monitors 'ENE-MATES' to have lecture meetings and site tours. ENE-MATES - A Public Information Program For Women. As a 1990 opinion poll shows, women's feelings about nuclear energy differ from that of men. Women are more sensitive and anxious than men on nuclear energy issues. To improve this situation several programs for women have been planned and implemented.'ENE-MATES' program is one of these cases. It's purpose is to encourage women, centering around house wives, to have unbiased understanding of energy-related issues

  15. On the reaction of the nitroso group with olefins. Mechanisms of ene reactions

    International Nuclear Information System (INIS)

    Seymour, C.A.; Greene, F.D.

    1982-01-01

    Intra- and intermolecular isotope effects point to a two-step process for the reaction of pentafluoronitrosobenzene with tetramethylethylene to afford the ene product, rate-determining formation of an intermediate (for which the arizidine N-oxide is suggested) followed by C-H (or C-D) cleavage to the ene product

  16. Novel Thiol-Ene Hybrid Coating for Metal Protection

    Directory of Open Access Journals (Sweden)

    Mona Taghavikish

    2016-04-01

    Full Text Available A novel hybrid anticorrosion coating with dual network of inorganic (Si–O–Si and organic bonds (C–S–C was prepared on metal through an in situ sol-gel and thiol-ene click reaction. This novel interfacial thin film coating incorporates (3-mercaptopropyl trimethoxysilane (MPTS and 1,4-di(vinylimidazolium butane bisbromide based polymerizable ionic liquid (PIL to form a thiol-ene based photo-polymerized film, which on subsequent sol-gel reaction forms a thin hybrid interfacial layer on metal surface. On top of this PIL hybrid film, a self-assembled nanophase particle (SNAP coating was employed to prepare a multilayer thin film coating for better corrosion protection and barrier performance. The novel PIL hybrid film was characterised for structure and properties using Fourier transform infrared spectroscopy (FTIR, differential scanning calorimetry (DSC, and thermogravimetric analysis (TGA. The corrosion protection performance of the multilayer coating was examined using potentiodynamic polarization and electrochemical impedance spectroscopy (EIS. The results reveal that this novel double layer coating on metal offers excellent protection against corrosion and has remarkably improved the barrier effect of the coating.

  17. Continuous Flow Science in an Undergraduate Teaching Laboratory: Photocatalytic Thiol-Ene Reaction Using Visible Light

    Science.gov (United States)

    Santandrea, Jeffrey; Kairouz, Vanessa; Collins, Shawn K.

    2018-01-01

    An undergraduate teaching laboratory experiment involving a continuous flow, photocatalytic thiol-ene reaction using visible-light irradiation is described that allows students to explore concepts of green chemistry, photochemistry, photocatalysis, and continuous flow chemistry.

  18. Investigations of thiol-modified phenol derivatives for the use in thiol–ene photopolymerizations

    OpenAIRE

    Sebastian Reinelt; Monir Tabatabai; Urs Karl Fischer; Norbert Moszner; Andreas Utterodt; Helmut Ritter

    2014-01-01

    Summary Thiol–ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol–ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate) (PETMP), is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-m...

  19. Draama 2007. Töörahu / Ene Paaver

    Index Scriptorium Estoniae

    Paaver, Ene, 1963-

    2008-01-01

    Ülevaade 2007. aasta eesti draamast. Pikemalt käsitletakse järgmisi autoreid ja nende näidendeid: Mart Kivastik "Tõnu võitlused", Mart Kivastik "Eesti asi", Mart Kivastik "Sõdur", Mart Kivastik "Kuninga viimane lahing ja ülikooli algus", Mart Kivastik, "Nokia 3310", Andrus Kivirähk "Voldemar", Andrus Kivirähk "Uljas neitsi", Hendrik Toompere "Kommunisti surm", Andres Ehin "Saatuslik kihlvedu ehk Volquin Varbola all", Jan Rahman "Jõujaam", Jaak Kõdar "Muinassaar", Karl Berg "Teekond valguse riiki", Angela Randmets "Lembelood vanas linnas", Toomas Kall "Tähtede sadu", Lauri Vahtre "Muna EÜE", Urmas Espenberg "Kestvad kiiduavaldused", Kalju Saaber "Koduvõõrad", Indrek Hirv "Pauluse kiriku kellad", Katrin Saukas "Võlg", Heidi Sarapuu "Austatud Riigikogu liikmed!", Heidi Sarapuu "Helisev viis", Heidi Sarapuu "Ankur hiivata", Jakob Karu "Vanaema juures", Jim Ashilevi "Nagu poisid vihma käes", Jim Ashilevi "Portselansuits", Eva Koff "Mirr", Jaak Prints "Karaoke", Kati Murutar "Mina, naine!", Ott Aardam "Börs ja Börsitar", Andrus Kivirähk, Jan Rahman, Contra "Kõrts", Mart Kase "Perekond", Villu Tamme "Haned võlgu"; Tiit Ojasoo ja Ene-Liis Semperi "GEP ehk Gorjatshije estonskije parni"

  20. Simple preparation of thiol-ene particles in glycerol and surface functionalization by thiol-ene chemistry (TEC) and surface chain transfer free radical polymerization (SCT-FRP)

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Chiaula, Valeria; Yu, Liyun

    2018-01-01

    functionalization of excess thiol groups via photochemical thiol-ene chemistry (TEC) resulting in a functional monolayer. In addition, surface chain transfer free radical polymerization (SCT-FRP) was used for the first time to introduce a thicker polymer layer on the particle surface. The application potential...

  1. Ene-Liis Semper : hindan päeva, kui teen ühte asja / Ene-Liis Semper ; interv. Jaanus Kulli

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2008-01-01

    Teatri- ja videokunstnik Ene-Liis Semper oma elust ja tööst. Lisaks repliik "Parim päev on tööst prii päev" ja peagi Teater NO99s esietenduvast William Shakespeare'i lavastusest "Muinasjutuline "Perikles"

  2. Preparation and Preliminary Dielectric Characterization of Structured C60-Thiol-Ene Polymer Nanocomposites Assembled Using the Thiol-Ene Click Reaction

    Directory of Open Access Journals (Sweden)

    Hanaa M. Ahmed

    2015-11-01

    Full Text Available Fullerene-containing materials have the ability to store and release electrical energy. Therefore, fullerenes may ultimately find use in high-voltage equipment devices or as super capacitors for high electric energy storage due to this ease of manipulating their excellent dielectric properties and their high volume resistivity. A series of structured fullerene (C60 polymer nanocomposites were assembled using the thiol-ene click reaction, between alkyl thiols and allyl functionalized C60 derivatives. The resulting high-density C60-urethane-thiol-ene (C60-Thiol-Ene networks possessed excellent mechanical properties. These novel networks were characterized using standard techniques, including infrared spectroscopy (FTIR, differential scanning calorimetry (DSC, dynamic mechanical analysis (DMA, and thermal gravimetric analysis (TGA. The dielectric spectra for the prepared samples were determined over a broad frequency range at room temperature using a broadband dielectric spectrometer and a semiconductor characterization system. The changes in thermo-mechanical and electrical properties of these novel fullerene-thiol-ene composite films were measured as a function of the C60 content, and samples characterized by high dielectric permittivity and low dielectric loss were produced. In this process, variations in chemical composition of the networks were correlated to performance characteristics.

  3. Rapid and simple preparation of thiol-ene emulsion-templated monoliths and their application as enzymatic microreactors

    DEFF Research Database (Denmark)

    Lafleur, Josiane P; Senkbeil, Silja; Novotny, Jakub

    2015-01-01

    A novel, rapid and simple method for the preparation of emulsion-templated monoliths in microfluidic channels based on thiol-ene chemistry is presented. The method allows monolith synthesis and anchoring inside thiol-ene microchannels in a single photoinitiated step. Characterization by scanning...... electron microscopy showed that the methanol-based emulsion templating process resulted in a network of highly interconnected and regular thiol-ene beads anchored solidly inside thiol-ene microchannels. Surface area measurements indicate that the monoliths are macroporous, with no or little micro...

  4. Investigations of thiol-modified phenol derivatives for the use in thiol-ene photopolymerizations.

    Science.gov (United States)

    Reinelt, Sebastian; Tabatabai, Monir; Fischer, Urs Karl; Moszner, Norbert; Utterodt, Andreas; Ritter, Helmut

    2014-01-01

    Thiol-ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol-ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate) (PETMP), is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-modified bis- and trisphenol derivatives in thiol-ene photopolymerizations. For this, six different thiol-modified bis- and trisphenol derivatives exhibiting four to six thiol groups are synthesized via the radical addition of thioacetic acid to suitable allyl-modified precursors and subsequent hydrolysis. Compared to PETMP better flexural strength and modulus of elasticity are achievable in thiol-ene photopolymerizations employing 1,3,5-triallyl-1,3,5-triazine-2,4,6-trione (TATATO) as the ene derivative. Especially, after storage in water, the flexural strength and modulus of elasticity is twice as high compared to the PETMP reference system.

  5. Investigations of thiol-modified phenol derivatives for the use in thiol–ene photopolymerizations

    Science.gov (United States)

    Reinelt, Sebastian; Tabatabai, Monir; Fischer, Urs Karl; Moszner, Norbert; Utterodt, Andreas

    2014-01-01

    Summary Thiol–ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol–ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate) (PETMP), is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-modified bis- and trisphenol derivatives in thiol–ene photopolymerizations. For this, six different thiol-modified bis- and trisphenol derivatives exhibiting four to six thiol groups are synthesized via the radical addition of thioacetic acid to suitable allyl-modified precursors and subsequent hydrolysis. Compared to PETMP better flexural strength and modulus of elasticity are achievable in thiol–ene photopolymerizations employing 1,3,5-triallyl-1,3,5-triazine-2,4,6-trione (TATATO) as the ene derivative. Especially, after storage in water, the flexural strength and modulus of elasticity is twice as high compared to the PETMP reference system. PMID:25161731

  6. Investigations of thiol-modified phenol derivatives for the use in thiol–ene photopolymerizations

    Directory of Open Access Journals (Sweden)

    Sebastian Reinelt

    2014-07-01

    Full Text Available Thiol–ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol–ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate (PETMP, is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-modified bis- and trisphenol derivatives in thiol–ene photopolymerizations. For this, six different thiol-modified bis- and trisphenol derivatives exhibiting four to six thiol groups are synthesized via the radical addition of thioacetic acid to suitable allyl-modified precursors and subsequent hydrolysis. Compared to PETMP better flexural strength and modulus of elasticity are achievable in thiol–ene photopolymerizations employing 1,3,5-triallyl-1,3,5-triazine-2,4,6-trione (TATATO as the ene derivative. Especially, after storage in water, the flexural strength and modulus of elasticity is twice as high compared to the PETMP reference system.

  7. Surface modification of cyclomatrix polyphosphazene microsphere by thiol-ene chemistry and lectin recognition

    International Nuclear Information System (INIS)

    Chen, Chen; Zhu, Xue-yan; Gao, Qiao-ling; Fang, Fei; Huang, Xiao-jun

    2016-01-01

    Graphical abstract: A new synthetic route leading to polyphosphazene cyclomatrix microsphere with various functional groups has achieved via thiol-ene click modification. Herein, hexacholorocyclophosphazene (HCCP) crosslinked with bisphenol-S and 4,4′-diallyl bisphenol-S to generate broadly dispersed microspheres. Thiol-ene modification under UV irradiation not only presented high efficiency and flexibility for post-functionalization, but also imposed no harm on global morphology and crosslinked skeleton of such microspheres. - Highlights: • Functional polyphosphazene microspheres with high chemical flexibility were synthesized by thiol-ene modification. • Polyphosphazene microspheres possessed high thermal stability. • Glycosylated polyphosphazene microspheres showed affinity to lectin Con-A, which inferred potential application in biomedicine. - Abstract: A new synthetic route leading to functional polyphosphazene cyclomatrix microsphere has been developed via thiol-ene click modification. Hexacholorocyclophosphazene (HCCP) was crosslinked with both bisphenol-S and 4,4′-diallyl bisphenol-S to obtain vinyl polyphosphazene microspheres (VPZM) in order to ensure high crosslinking degree and introduce vinyl moieties. Compared to the microspheres obtained by HCCP and bisphenol-S, the size of VPZM was broadly dispersed from 400 nm to 1.40 μm. Thiol-ene click reactions were carried out to attach functional groups, such as glucosyl, carboxyl, ester and dodecyl groups onto polyphosphazene microspheres, which demonstrated no change in morphology and size after modification. Solid state NMR (SSNMR) and Fourier transform infrared spectoscopy (FT-IR) results showed that the vinyl moieties were introduced in the period of crosslinking and functionalization was also successful via click reactions. Moreover, the microspheres presented a little difference in thermal properties after modification. Concanavalin A (Con-A) fluorescent adsorption was also observed for

  8. Surface modification of cyclomatrix polyphosphazene microsphere by thiol-ene chemistry and lectin recognition

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chen; Zhu, Xue-yan; Gao, Qiao-ling; Fang, Fei; Huang, Xiao-jun, E-mail: hxjzxh@zju.edu.cn

    2016-11-30

    Graphical abstract: A new synthetic route leading to polyphosphazene cyclomatrix microsphere with various functional groups has achieved via thiol-ene click modification. Herein, hexacholorocyclophosphazene (HCCP) crosslinked with bisphenol-S and 4,4′-diallyl bisphenol-S to generate broadly dispersed microspheres. Thiol-ene modification under UV irradiation not only presented high efficiency and flexibility for post-functionalization, but also imposed no harm on global morphology and crosslinked skeleton of such microspheres. - Highlights: • Functional polyphosphazene microspheres with high chemical flexibility were synthesized by thiol-ene modification. • Polyphosphazene microspheres possessed high thermal stability. • Glycosylated polyphosphazene microspheres showed affinity to lectin Con-A, which inferred potential application in biomedicine. - Abstract: A new synthetic route leading to functional polyphosphazene cyclomatrix microsphere has been developed via thiol-ene click modification. Hexacholorocyclophosphazene (HCCP) was crosslinked with both bisphenol-S and 4,4′-diallyl bisphenol-S to obtain vinyl polyphosphazene microspheres (VPZM) in order to ensure high crosslinking degree and introduce vinyl moieties. Compared to the microspheres obtained by HCCP and bisphenol-S, the size of VPZM was broadly dispersed from 400 nm to 1.40 μm. Thiol-ene click reactions were carried out to attach functional groups, such as glucosyl, carboxyl, ester and dodecyl groups onto polyphosphazene microspheres, which demonstrated no change in morphology and size after modification. Solid state NMR (SSNMR) and Fourier transform infrared spectoscopy (FT-IR) results showed that the vinyl moieties were introduced in the period of crosslinking and functionalization was also successful via click reactions. Moreover, the microspheres presented a little difference in thermal properties after modification. Concanavalin A (Con-A) fluorescent adsorption was also observed for

  9. Evaluation and Control of Thiol-ene/Thiol-epoxy Hybrid Networks

    OpenAIRE

    Carioscia, Jacquelyn A.; Stansbury, Jeffrey W.; Bowman, Christopher N.

    2007-01-01

    The development of thiol-ene/thiol-epoxy hybrid networks offers the advantage of tailorable polymerization kinetics while producing a highly crosslinked, high Tg polymer that has significantly reduced shrinkage stress. Stoichiometric mixtures of pentaerythritol tetra(3-mercaptopropionate) (PETMP)/triallyl-1,3,5-triazine-2,4,6-trione (TATATO) (thiol-ene, mixture 1) and PETMP/bisphenol a diglycidyl ether (BADGE) (thiol-epoxy, mixture 2) were prepared and hybrid mixtures of 75/25, 50/50, 25/75, ...

  10. Fabrication of Biomolecule Microarrays Using Rapid Photochemical Surface Patterning in Thiol-Ene-Based Microfluidic Devices.

    Science.gov (United States)

    Jönsson, Alexander; Lafleur, Josiane P

    2018-01-01

    In many biochip applications, it is advantageous to be able to immobilize biomolecules at specific locations on the surface of solid supports. In this protocol, we describe a photochemical surface patterning procedure based on thiol-ene/yne photochemistry which allows for the simple and rapid selective patterning of biomolecules on thiol-ene solid supports. We describe the preparation of solid supports which are required for the immobilization, including porous monoliths, as well as two different immobilization schemes based on biotin-streptavidin interactions and covalent linkage via free amino groups respectively.

  11. Preparation and Characterization of Fluorinated Hydrophobic UV-Crosslinkable Thiol-Ene Polyurethane Coatings

    Directory of Open Access Journals (Sweden)

    Wenjing Xia

    2017-08-01

    Full Text Available The polyurethane prepolymer terminated with a double bond was synthesized using isophorone diisocyanate (IPDI, hydroxyl terminated polybutadiene (HTPB, 1,4-butanediol (BDO, and 2-hydroxyethyl acrylate (HEA. Then, a series of innovative UV-curable polyurethane coatings were prepared by blending ene-terminated polyurethane, fluoroacrylate monomer, and multifunctional thiol crosslinker upon UV exposure. The incorporation of fluoroacrylate monomer and multifunctional thiols into polyurethane coatings significantly enhanced the hydrophobic property, mechanical property, pencil hardness, and glossiness of the polyurethane coatings. This method of preparing UV crosslinkable, hydrophobic polyurethane coatings based on thiol-ene chemistry exhibited numerous advantages over other UV photocuring systems.

  12. Episodic nature of the delta 4-ene and delta 5-ene steroidogenic pathways and their relationship to the adreno-gonadal axis in stallions.

    Science.gov (United States)

    Ganjam, V K

    1979-01-01

    Changes in the daily secretory patterns of testosterone and other 17 beta-hydroxyandrogen, total oestrogens and total corticoids were investigated in 7 stallions. Pulsatile fluctuations in plasma hormone levels were found in the serial blood samples collected hourly for 24 h in all animals. The plasma profiles indicated that corticoids, oestrogens and androgens were secreted episodically at all times in stallions. A significant correlation was observed between the precursor and products of delta 4-ene and delta 5-ene pathways and in inverse correlation (r = -0.68; P less than 0.01) was observed between total androgens and total corticoids. The significance of these episodic fluctuations of the major steroid hormones are discussed.

  13. Patterned Hydrophilization of Nanoporous 1,2‐PB by Thiol‐ene Photochemistry

    DEFF Research Database (Denmark)

    Berthold, Anton; Sagar, Kaushal Shashikant; Ndoni, Sokol

    2011-01-01

    is monitored by FT‐IR, UV–Vis, contact angle, and gravimetry. Overall quantum yields are calculated for the two thiol‐ene “click” reactions in nano‐confinement, neatly revealing their chain‐like nature. Top–down photolithographic patterning is demonstrated, realizing hydrophilic nanoporous “corridors...

  14. DFT Investigation of the Palladium-Catalyzed Ene-Yne Coupling

    DEFF Research Database (Denmark)

    Henriksen, Signe Teuber; Tanner, David Ackland; Skrydstrup, T.

    2010-01-01

    ). Concerning chemoselectivity, the calculations also clarify why the ene-yne coupling is able to dominate over plausible alternative reaction pathways such as alkene homocoupiing and alkyne polymerization. The role of the phosphine ligand at various stages of the catalytic cycle has also been delineated....

  15. Evaluation and Control of Thiol-ene/Thiol-epoxy Hybrid Networks.

    Science.gov (United States)

    Carioscia, Jacquelyn A; Stansbury, Jeffrey W; Bowman, Christopher N

    2007-03-08

    The development of thiol-ene/thiol-epoxy hybrid networks offers the advantage of tailorable polymerization kinetics while producing a highly crosslinked, high T(g) polymer that has significantly reduced shrinkage stress. Stoichiometric mixtures of pentaerythritol tetra(3-mercaptopropionate) (PETMP)/triallyl-1,3,5-triazine-2,4,6-trione (TATATO) (thiol-ene, mixture 1) and PETMP/bisphenol a diglycidyl ether (BADGE) (thiol-epoxy, mixture 2) were prepared and hybrid mixtures of 75/25, 50/50, 25/75, and 10/90 w/w of mixtures 1 and 2 were polymerized using a combination of both radical and anionic initiation. The light exposure timing and the relative initiation conditions of the two types were used to control the order and relative rates of the radical and anionic polymerizations. The 50/50 w/w thiol-ene/thiol-epoxy hybrid material exhibited a final stress of only 0.2 MPa, which is 90 % lower than the stress developed in a control dimethacrylate resin. Kinetic analysis indicates composition affects network development in thiol-ene/thiol-epoxy hybrid networks and produces materials with robust mechanical properties.

  16. Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis

    KAUST Repository

    Baumgartner, Corinne

    2010-01-01

    Our efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted S N2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention of stereochemistry. © 2010 The Royal Society of Chemistry.

  17. Preparation of Biomolecule Microstructures and Microarrays by Thiol–ene Photoimmobilization

    NARCIS (Netherlands)

    Weinrich, Dirk; Köhn, Maja; Jonkheijm, Pascal; Westerlind, Ulrika; Dehmelt, Leif; Engelkamp, Hans; Christianen, Peter C.M.; Kuhlmann, Jürgen; Maan, Jan C.; Nüsse, Dirk; Schröder, Hendrik; Wacker, Ron; Voges, Edgar; Breinbauer, Rolf; Kunz, Horst; Niemeyer, Christof M.; Waldmann, Herbert

    2010-01-01

    A mild, fast and flexible method for photoimmobilization of biomolecules based on the light-initiated thiol–ene reaction has been developed. After investigation and optimization of various surface materials, surface chemistries and reaction parameters, microstructures and microarrays of biotin,

  18. Rapid photochemical surface patterning of proteins in thiol-ene based microfluidic devices

    DEFF Research Database (Denmark)

    Lafleur, Josiane P.; Kwapiszewski, Radoslaw; Jensen, Thomas Glasdam

    2013-01-01

    ! 17 SH nm"2. Biotin alkyne was patterned directly inside thiol–ene microchannels prior to conjugation with fluorescently labelled streptavidin. The surface bound conjugates were detected by evanescent waveinduced fluorescence (EWIF), demonstrating the success of the grafting procedure and its...

  19. Rapid photochemical surface patterning of proteins in thiol-ene based microfluidic devices

    DEFF Research Database (Denmark)

    Lafleur, Josiane P.; Kwapiszewski, Radoslaw; Jensen, Thomas Glasdam

    2012-01-01

    ” and “ene” monomers present in the microfluidic chip bulk material provides a simple and efficient way of tuning the chip’s surface chemistry. Here, thiol-ene chips displaying an excess of functional thiol groups at their surfaces are functionalized with biotin and streptavidin in a controlled fashion using...

  20. Orented immobilization of farnesylated proteins by the thiol-ene reaction

    NARCIS (Netherlands)

    Weinrich, Dirk; Lin, Po-Chiao; Jonkheijm, Pascal; Nguyen, Uyen T.T.; Schröder, Hendrik; Niemeyer, Christof M.; Alexandrov, Kirill; Goody, Roger; Waldmann, Herbert

    2010-01-01

    Anchoring the protein: Proteins were immobilized rapidly under mild conditions by thiol-ene photocoupling between S-farnesyl groups attached to a genetically encodable “CAAX-box” tetrapeptide sequence (A is aliphatic) at the C terminus of the protein and surface-exposed thiols (see scheme). This

  1. Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis

    KAUST Repository

    Baumgartner, Corinne; Ma, Sandy; Liu, Qi; Stoltz, Brian M.

    2010-01-01

    Our efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted S N2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention

  2. Heat- and light-induced thiol-ene oligomerization of soybean oil-based polymercaptan

    Science.gov (United States)

    Polymercaptanized soybean oil (PMSO), the product of a thiol-ene reaction between soybean oil and hydrogen sulfide, is a material of interest as a lubricant additive and polymer precursor. We investigated with gel permeation chromatography, nuclear magnetic resonance (one-dimensional and two-dimensi...

  3. Functionalization of embedded thiol-ene waveguides for evanescent wave induced fluorescence detection in a microfluidic device

    DEFF Research Database (Denmark)

    Feidenhans'l, Nikolaj Agentoft; Jensen, Thomas Glasdam; Lafleur, Josiane P.

    2013-01-01

    We demonstrate the use of functional surface groups inherently present on off-stoichiometric thiol−ene polymers, for site-specific immobilization of biomolecules and detection by evanescent wave-induced fluorescence. An optofluidic chip featuring an embedded thiol−ene waveguide was selectively...... functionalized with biotin using photografting. The biotin was used for immobilization of fluorescently labelled streptavidin, and experiments revealed a linear correlation between streptavidin concentration and fluorescent intensity. To further demonstrate the attractiveness of using thiol−ene for optofluidic...

  4. A Study of Functional Polymer Colloids Prepared Using Thiol-Ene/Yne Click Chemistry

    Science.gov (United States)

    Durham, Olivia Z.

    This project demonstrates the first instance of thiol-ene chemistry as the polymerization method for the production of polymer colloids in two-phase heterogeneous suspensions, miniemulsions, and emulsions. This work was also expanded to thiol-yne chemistry for the production of polymer particles containing increased crosslinking density. The utility of thiol-ene and thiol-yne chemistries for polymerization and polymer modification is well established in bulk systems. These reactions are considered 'click' reactions, which can be defined as processes that are both facile and simple, offering high yields with nearly 100% conversion, no side products, easy product separation, compatibility with a diverse variety of commercially available starting materials, and orthogonality with other chemistries. In addition, thiol-ene and thiol-yne chemistry follow a step-growth mechanism for the development of highly uniform polymer networks, where polymer growth is dependent on the coupling of functional groups. These step-growth polymerization systems are in stark contrast to the chain-growth mechanisms of acrylic and styrenic monomers that have dominated the field of conventional heterogeneous polymerizations. Preliminary studies evaluated the mechanism of particle production in suspension and miniemulsion systems. Monomer droplets were compared to the final polymer particles to confirm that particle growth occurred through the polymerization of monomer droplets. Additional parameters examined include homogenization energy (mechanical mixing), diluent species and concentration, and monomer content. These reactions were conducted using photoinitiation to yield particles in a matter of minutes with diameters in the size range of several microns to hundreds of microns in suspensions or submicron particles in miniemulsions. Improved control over the particle size and size distribution was examined through variation of reaction parameters. In addition, a method of seeded suspension

  5. Superhydrophobic hybrid inorganic-organic thiol-ene surfaces fabricated via spray-deposition and photopolymerization.

    Science.gov (United States)

    Sparks, Bradley J; Hoff, Ethan F T; Xiong, Li; Goetz, James T; Patton, Derek L

    2013-03-13

    We report a simple and versatile method for the fabrication of superhydrophobic inorganic-organic thiol-ene coatings via sequential spray-deposition and photopolymerization under ambient conditions. The coatings are obtained by spray-deposition of UV-curable hybrid inorganic-organic thiol-ene resins consisting of pentaerythritol tetra(3-mercaptopropionate) (PETMP), triallyl isocyanurate (TTT), 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane (TMTVSi), and hydrophobic fumed silica nanoparticles. The spray-deposition process and nanoparticle agglomeration/dispersion provide surfaces with hierarchical morphologies exhibiting both micro- and nanoscale roughness. The wetting behavior, dependent on the concentration of TMTVSi and hydrophobic silica nanoparticles, can be varied over a broad range to ultimately provide coatings with high static water contact angles (>150°), low contact angle hysteresis, and low roll off angles (spray-deposition and UV-cure process on a variety of substrate surfaces including glass, paper, stone, and cotton fabric.

  6. Ene-Liis Semper : Kohalolu piiritsoonis = Presence in the border zone / Anu Allas

    Index Scriptorium Estoniae

    Allas, Anu, 1977-

    2007-01-01

    Teatri- ja videokunstnik Ene-Liis Semperi peamiselt 1990-ndate aastate videotest, mis on valdavalt rõhutatult lavastuslikud, paisutatult sümbolistlikud või kus on esitatud piirsituatsioone, ahistust ning selle teadlikku eksponeerimist väljakutsena publikule. Iseennast paljastades, alandades ja ohtu seades jääb kunstnik enamasti jahedalt distantseerituks, publikule jääb aga arusaamatuks, kas tegemist on ohvri, kangelanna või osava mänguriga

  7. Heterofunctional Glycopolypeptides by Combination of Thiol-Ene Chemistry and NCA Polymerization.

    Science.gov (United States)

    Krannig, Kai-Steffen; Schlaad, Helmut

    2016-01-01

    Glycopolypeptides are prepared either by the polymerization of glycosylated amino acid N-carboxyanhydrides (NCAs) or by the post-polymerization functionalization of polypeptides with suitable functional groups. Here we present a method for the in-situ functionalization and (co-) polymerization of allylglycine N-carboxyanhydride in a facile one-pot procedure, combining radical thiol-ene photochemistry and nucleophilic ring-opening polymerization techniques, to yield well-defined heterofunctional glycopolypeptides.

  8. Preparation and Characterization of Fluorinated Hydrophobic UV-Crosslinkable Thiol-Ene Polyurethane Coatings

    OpenAIRE

    Wenjing Xia; Nianqing Zhu; Rongjie Hou; Wengui Zhong; Mingqing Chen

    2017-01-01

    The polyurethane prepolymer terminated with a double bond was synthesized using isophorone diisocyanate (IPDI), hydroxyl terminated polybutadiene (HTPB), 1,4-butanediol (BDO), and 2-hydroxyethyl acrylate (HEA). Then, a series of innovative UV-curable polyurethane coatings were prepared by blending ene-terminated polyurethane, fluoroacrylate monomer, and multifunctional thiol crosslinker upon UV exposure. The incorporation of fluoroacrylate monomer and multifunctional thiols into polyurethane ...

  9. Thiol-ene reaction as tool for crosslinking of polynorbornene micelles in the nanoscale

    Science.gov (United States)

    Rupp, Barbara; Bauer, Thomas; Slugovc, Christian

    2009-08-01

    The thiol-ene reaction is a established photoreaction of multifunctional thiols and enes. Virtually any type of ene will participate in a free radical polymerisation process with a thiol. An advantage over many other photochemical reactions is that the reaction proceeds almost as rapidly in ambient conditions as in inert atmosphere. In this work we introduce the UV-crosslinking of polynorbornenes made by ring opening metathesis polymerization making use of the residual double bond in the polymer backbone. The crosslinking experiments were done in thin films and were followed by FTIR measurements, to proof the accessibility of double-bonds in the polymers for the addition of the thiols. As a result of these pre-experiments we created flexible and light transmitting films. To further increase the scope of this reaction, amphiphilic block copolymers were prepared and used to form block copolymer micelles in a selective solvent, which were subsequently crosslinked with pentaerythritol tetra(3-mercaptopropionate) (PETMP). FT-IR, DLS and SEM-measurements were used to prove the successful crosslinking and thus nanoparticle formation.

  10. Antibiofouling hybrid dendritic Boltorn/star PEG thiol-ene cross-linked networks.

    Science.gov (United States)

    Bartels, Jeremy W; Imbesi, Philip M; Finlay, John A; Fidge, Christopher; Ma, Jun; Seppala, Jonathan E; Nystrom, Andreas M; Mackay, Michael E; Callow, James A; Callow, Maureen E; Wooley, Karen L

    2011-06-01

    A series of thiol-ene generated amphiphilic cross-linked networks was prepared by reaction of alkene-modified Boltorn polyesters (Boltorn-ene) with varying weight percent of 4-armed poly(ethylene glycol) (PEG) tetrathiol (0-25 wt%) and varying equivalents of pentaerythritol tetrakis(3-mercaptopropionate) (PETMP) (0-64 wt%). These materials were designed to present complex surface topographies and morphologies, with heterogeneity of surface composition and properties and robust mechanical properties, to serve as nontoxic antibiofouling coatings that are amenable to large-scale production for application in the marine environment. Therefore, a two-dimensional matrix of materials compositions was prepared to study the physical and mechanical properties, over which the compositions spanned from 0 to 25 wt% PEG tetrathiol and 0-64 wt% PETMP (the overall thiol/alkene (SH/ene) ratios ranged from 0.00 to 1.00 equiv), with both cross-linker weight percentages calculated with respect to the weight of Boltorn-ene. The Boltorn-ene components were prepared through the esterification of commercially available Boltorn H30 with 3-butenoic acid. The subsequent cross-linking of the Boltorn-PEG-PETMP films was monitored using IR spectroscopy, where it was found that near-complete consumption of both thiol and alkene groups occurred when the stoichiometry was ca. 48 wt% PETMP (0.75 equiv SH/ene, independent of PEG amount). The thermal properties of the films showed an increase in T(g) with an increase in 4-armed PEG-tetrathiol wt%, regardless of the PETMP concentration. Investigation of the bulk mechanical properties in dry and wet states found that the Young's modulus was the greatest at 48 wt% PETMP (0.75 equiv of SH/ene). The ultimate tensile strength increased when PETMP was constant and the PEG concentration was increased. The Young's modulus was slightly lower for wet films at constant PEG or constant PETMP amounts, than for the dry samples. The nanoscopic surface features were

  11. Advantages and drawbacks of Thiol-ene based resins for 3D-printing

    Science.gov (United States)

    Leonards, Holger; Engelhardt, Sascha; Hoffmann, Andreas; Pongratz, Ludwig; Schriever, Sascha; Bläsius, Jana; Wehner, Martin; Gillner, Arnold

    2015-03-01

    The technology of 3D printing is conquering the world and awakens the interest of many users in the most varying of applications. New formulation approaches for photo-sensitive thiol-ene resins in combination with various printing technologies, like stereolithography (SLA), projection based printing/digital light processing (DLP) or two-photon polymerization (TPP) are presented. Thiol-ene polymerizations are known for its fast and quantitative reaction and to form highly homogeneous polymer networks. As the resins are locally and temporally photo-curable the polymerization type is very promising for 3D-printing. By using suitable wavelengths, photoinitiator-free fabrication is feasible for single- and two photon induced polymerization. In this paper divinyl ethers of polyethylene glycols in combination with star-shaped tetrathiols were used to design a simple test-system for photo-curable thiol-ene resins. In order to control and improve curing depth and lateral resolution in 3D-polymerization processes, either additives in chemical formulation or process parameters can be changed. The achieved curing depth and resolution limits depend on the applied fabrication method. While two-/multiphoton induced lithography offers the possibility of micron- to sub-micron resolution it lacks in built-up speed. Hence single-photon polymerization is a fast alternative with optimization potential in sub-10-micron resolution. Absorber- and initiator free compositions were developed in order to avoid aging, yellowing and toxicity of resulting products. They can be cured with UV-laser radiation below 300 nm. The development at Fraunhofer ILT is focusing on new applications in the field of medical products and implants, technical products with respect to mechanical properties or optical properties of 3D-printed objects. Recent process results with model system (polyethylene glycol divinylether/ Pentaerithrytol tetrakis (3-mercaptopropionat), Raman measurements of polymer conversion

  12. Investigations of step-growth thiol-ene polymerizations for novel dental restoratives.

    Science.gov (United States)

    Lu, Hui; Carioscia, Jacquelyn A; Stansbury, Jeffery W; Bowman, Christopher N

    2005-12-01

    The goal of this work was to investigate the feasibility of formulating novel dental restorative materials that utilize a step-growth thiol-ene photopolymerization. Particularly, we are aiming to significantly reduce the polymerization shrinkage and shrinkage stress while retaining adequate physical properties as compared to current dimethacrylatre-based systems. The thiol-ene system is composed of a 4:3 molar mixture of triallyl-1,3,5-triazine-2,4,6-trione (TATATO) and pentaerythritol tetramercaptopropionate (PETMP). The simultaneous measurement of shrinkage stress and functional group conversion was performed. Solvent extraction of unreacted monomers and dynamic mechanical analysis on the polymer networks that were formed were also studied. Flexural strength was measured for both filled and unfilled PETMP/TATATO and Bis-GMA/TEGDMA systems. Photopolymerization of PETMP/TATATO occurs at a much higher rate, with the maximum polymerization rate six times faster, than Bis-GMA/TEGDMA cured under the identical conditions. The results from the simultaneous measurement of shrinkage stress and conversion showed that the onset of shrinkage stress coincides with the delayed gel point conversion, which is predicted to be 41% for the 3:4 stoichiometric PETMP/TATATO resin composition. The maximum shrinkage stress developed for PETMP/TATATO was about 0.4 MPa, which was only approximately 14% of the maximum shrinkage stress of the Bis-GMA/TEGDMA system. Adequate flexural strength and flexural modulus values were obtained for both filled and unfilled PETMP/TATATO systems. The dramatically reduced shrinkage stress, increased polymerization rate, significance increased functional group conversion, and decreased leachable species are all benefits for the use-of thiol-ene systems as potential dental restorative materials.

  13. Synergistic Diazo-OH Insertion/Conia-Ene Cascade Catalysis for the Stereoselective Synthesis of γ-Butyrolactones and Tetrahydrofurans.

    Science.gov (United States)

    Hunter, Arianne C; Schlitzer, Steven C; Sharma, Indrajeet

    2016-11-02

    A novel and highly efficient diazo-OH insertion/Conia-ene cascade reaction of readily available homopropargylic acids and alcohols with diazo carbonyl compounds is described. The cascade reaction involves a synergistic Rh/Ag/Au catalyst cocktail and proceeds instantly with a variety of substituted diazo compounds and acids/alcohols to provide functionalized γ-butyrolactones and tetrahydrofurans with complete regio- and stereoselectivity. The unprecedented rate-enhancement, complete stereoselectivity, and the enabling of new Conia-ene cyclizations suggest a concerted [4+1]-cycloaddition reaction pathway under synergistic (Rh/Ag/Au)-catalysis conditions. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Synthesis and characterization of thiol-ene functionalized siloxanes and evaluation of their polymerization kinetics, network properties, and dental applications

    Science.gov (United States)

    Cole, Megan A.

    We explored formation-structure-property relationships in thiol-ene functionalized oligosiloxanes to create crosslinked networks. Specifically, nine oligomers were synthesized, three with thiol-functional silane repeats and three with allyl-functional silane repeats. Structural variations in each oligomer were systematically induced through the incorporation of non-reactive repeats bearing either diphenyl or di-n-octyl moieties, and the oligomer molecular weight was limited by the presence of monofunctional silane condensation species. The molecular weights and chain compositions of all oligomers were ascertained and subsequently used in the evaluation of network properties formed upon photopolymerization of thiol- and ene-functional reactants. Polymerization kinetics of the thiol-ene functionalized siloxanes were also investigated using photoinitiation owing to the spatial and temporal control afforded by this technique. In particular, the effects of the viscosity of the ene-functionalized oligomer and the degree of thiol functionalization on the observed polymerization rate were determined. Results showed that the speed of polymerization varied with changes to the rate-limiting step, which was heavily influenced by neighboring non-reactive functionalities. Moreover, the thiol-ene reaction was found to exhibity unimolecular termination exclusively in siloxane-based systems. Proposed use of the thiol-ene functionalized siloxane system as a dental impression material necessitated the development of a redox initiation scheme. Evaluation of the benzoylperoxide/dimethyl-p-toluidine redox pair in traditional systems showed bulk thiol-ene polymerizations comparable to photoinitiation with the added advantage of uninhibited depth control, as also demonstrated in small molecule thiol-ene coupling reactions initiated by this same redox system. Application of the redox pair to the siloxane system allowed for the viscoelastic properties as well as the feature replication

  15. Photocured thiol-ene based optical fluorescence sensor for determination of gold(III)

    Energy Technology Data Exchange (ETDEWEB)

    Çubuk, Soner, E-mail: sonercubuk@marmara.edu.tr; Kahraman, Memet Vezir; Yetimoğlu, Ece Kök; Kenan, Sibel

    2014-02-17

    Graphical abstract: -- Highlights: •Photopolymerized fluorescence sensor for Au(III) analysis has been developed. •Preparation of polymeric sensor is simple and quick. •Fluorescence sensor used for analysis of Au(III) in real samples. -- Abstract: This study describes the preparation and the characterization of a new thiol-ene based polymeric fluorescence sensor by photo initiated polymerization of trimethylolpropane tris(3-mercaptopropionate), 2-hydroxyethylacrylate, and 2,4,6-triallyloxy-1,3,5-triazine which are used as monomers and also a photo initiator (2,2-dimethoxy-2-phenylacetophenone) for its usage as optical sensor for gold ions. The thiol-ene based polymeric membrane sensor was characterized by using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR) and scanning electron microscopy (SEM). The response characteristics of the sensors including dynamic range, pH effect, response time, and the effect of foreign ions were investigated. Fluorescence spectra showed that the excitation/emission maxima of the membrane were at 379/425 nm, respectively.

  16. Preliminary Engineering Report contaminated groundwater seeps 317/319/ENE area

    International Nuclear Information System (INIS)

    1996-01-01

    When the Resource Conservation and Recovery Act Facility Investigation (RFI) in the 317/319/ENE Area of Argonne National Laboratory-East (ANL-E) was being completed, groundwater was discovered moving to the surface through a series of seeps. The seeps are located approximately 600 ft south of the ANL fence line in Waterfall Glen Forest Preserve. Samples of this water were collected and analyzed for selected parameters. Two of five seeps sampled were found to contain detectable levels of organic contaminants. Three chemical species were identified: chloroform (14-25 μg/L), carbon tetrachloride (56-340 μg/L), and tetrachloroethylene (3-6 μg/L). The other seeps did not contain detectable levels of volatile organic compounds (VOCs). The water issuing from these two contaminated seeps flows into a narrow ravine, where it is visible as a trickle of water flowing through sand and gravel deposits on the floor of the ravine. Approximately 100-ft downstream of the seep area, the contaminated water is no longer visible, having drained back into the soil in the bed of the ravine. Figure 1 shows the location of the 317/319/ENE Area in relation to the ANL-E site and the Waterfall Glen Forest Preserve

  17. Photocured thiol-ene based optical fluorescence sensor for determination of gold(III)

    International Nuclear Information System (INIS)

    Çubuk, Soner; Kahraman, Memet Vezir; Yetimoğlu, Ece Kök; Kenan, Sibel

    2014-01-01

    Graphical abstract: -- Highlights: •Photopolymerized fluorescence sensor for Au(III) analysis has been developed. •Preparation of polymeric sensor is simple and quick. •Fluorescence sensor used for analysis of Au(III) in real samples. -- Abstract: This study describes the preparation and the characterization of a new thiol-ene based polymeric fluorescence sensor by photo initiated polymerization of trimethylolpropane tris(3-mercaptopropionate), 2-hydroxyethylacrylate, and 2,4,6-triallyloxy-1,3,5-triazine which are used as monomers and also a photo initiator (2,2-dimethoxy-2-phenylacetophenone) for its usage as optical sensor for gold ions. The thiol-ene based polymeric membrane sensor was characterized by using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR) and scanning electron microscopy (SEM). The response characteristics of the sensors including dynamic range, pH effect, response time, and the effect of foreign ions were investigated. Fluorescence spectra showed that the excitation/emission maxima of the membrane were at 379/425 nm, respectively

  18. Rapid and simple preparation of thiol–ene emulsion-templated monoliths and their application as enzymatic microreactors

    Czech Academy of Sciences Publication Activity Database

    Lafleur, J. P.; Senkbeil, S.; Novotný, Jakub; Nys, G.; Bøgelund, N.; Rand, K. D.; Foret, František; Kutter, J. P.

    2015-01-01

    Roč. 15, č. 10 (2015), s. 2162-2172 ISSN 1473-0197 R&D Projects: GA ČR(CZ) GBP206/12/G014 Institutional support: RVO:68081715 Keywords : thiol-enes * mictoreactor * monolith * fabrication * proteins Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 5.586, year: 2015

  19. Kas erivajadustega lapsed saavad õigel ajal abi? / Ene Mägi, Urve Raudsepp-Alt, Ale Sprenk, Peeter Aas

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad: Tallinna Ülikooli Kasvatusteaduste Instituudi eri- ja sotsiaalpedagoogika osakonna juhataja Ene Mägi, Tallinna Haridusameti üldhariduse osakonna peaspetsialist Urve Raudsepp-Alt, Krabi põhikooli direktor Ale Sprenk, Põlva Maavalitsuse haridus-, kultuuri- ja sotsiaalosakonna juhataja Peeter Aas

  20. Koolirõõmuta kool on lapsele kui sunnitöö / Ene-Silvia Sarv ; intervjueerinud Karin Klaus

    Index Scriptorium Estoniae

    Sarv, Ene-Silvia, 1945-

    2013-01-01

    Intervjuu Pärnus hariduskonverentsil "Õnnelik õpilane, õnnelik õpetaja" esinenud Tallinna ülikooli lektori Ene-Silvia Sarvega, kes rääkis oma ettekandes, milline paistab tänapäeva kool õpilaste silme läbi ja mis mõjutab koolikliimat kõige enam

  1. Poly(ethylene glycol)-based thiol-ene hydrogel coatings: curing chemistry, aqueous stability, and potential marine antifouling applications

    NARCIS (Netherlands)

    Lundberg, P.; Bruin, A.; Klijnstra, J.W.; Nyström, A.M.; Johansson, M.; Malkoch, M.; Hult, A.

    2010-01-01

    Photocured thiol-ene hydrogel coatings based on poly(ethylene glycol) (PEG) were investigated for marine antifouling purposes. By varying the PEG length, vinylic end-group, and thiol cross-linker, a library of hydrogel coatings with different structural composition was efficiently accomplished, with

  2. High performance thiol-ene thermosets based on fully bio-based poly(limonene carbonate)s

    NARCIS (Netherlands)

    Li, C.; Johansson, M.; Sablong, R.J.; Koning, C.E.

    2017-01-01

    High glass transition temperature (Tg) thiol-ene networks (TENs) based on poly(limonene carbonate)s (PLCs), derived from orange oils and of potential degradability are described here. PLCs with moderate molecular weight were prepared by copolymerization of limonene oxide with CO2 and subsequent

  3. A Convergent Enantioselective Total Synthesis of (-)-Perhydrohistrionicotoxin with an Intramolecular Imino Ene-type Reaction as a Key Step

    DEFF Research Database (Denmark)

    Tanner, David Ackland; Hagberg, Lars

    1998-01-01

    A convergent enantioselective total synthesis of the neurotoxic spirocyclic alkaloid (-)-perhydrohistrionicotoxin (2) is described. A Lewis acid-mediated intramolecular imine ene-type reaction was used for the key spirocyclisation step (14 to 3, with 3 being obtained as a single diastereoisomer...

  4. Mida teie oma tervise heaks teete? / Ly Jagor, Ülle Mihhailova, Ene Pill, Katrin Käbin...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad Pärnu Õppenõustamiskeskuse psühholoog Ly Jagor, Maasika lasteaia juhataja asetäitja Ülle Mihhailova, Tallinna Perekeskuse ja Tähetorni lastekeskuse psühholoog Ene Pill, Tallinna Nõmme Noortemaja väikelaste ringijuht Katrin Käbin, Tääksi Põhikooli õpetaja Silva Kolk

  5. 1-Methoxy-3-o-tolylbicyclo[2.2.2]oct-5-ene-2,2-dicarbonitrile

    Directory of Open Access Journals (Sweden)

    Orhan Büyükgüngör

    2009-09-01

    Full Text Available In the title compound, C18H18N2O, the cyclohexene and cyclohexane rings of the bicyclo[2.2.2]oct-5-ene unit adopt distorted boat conformations. In the crystal, molecules exist as C—H...N hydrogen-bonded centrosymmetric R22(14 dimers, which are further linked by C—H...π interactions.

  6. Thermal decomposition of lanthanides (III) and yttrium (III) solid complexes from ethyl ene diamine tetraacetic acid

    International Nuclear Information System (INIS)

    Mercadante, A.

    1991-01-01

    Solid state compounds of lanthanides (III) and yttrium derived from ethyl ene diamine tetraacetic acid were prepared from respective basic carbonates, that were neutralized with EDTA stoichiometry quantities. Complexometry with EDTA, thermogravimetry (TG), differential thermal analysis (DTA) and X-ray diffraction have been used in the study of these compounds. The results of complexometry with EDTA as well as TG and DTA curves bed to the stoichiometry of these compounds the following general formula is obeyed: H[Ln(EDTA]. n H 2 O. X-ray powder patterns of these compounds permitted to establish two isomorphous series. The DTA ant TG curves allowed us to study the dehydration process, the thermal stability and thermal decomposition of these compounds. (C.G.C.)

  7. 3-(2-Benzofuranyl)quinuclidin-2-ene derivatives: novel muscarinic antagonists.

    Science.gov (United States)

    Nordvall, G; Sundquist, S; Johansson, G; Glas, G; Nilvebrant, L; Hacksell, U

    1996-08-16

    A series of 26 derivatives of the novel muscarinic antagonist 3-(2-benzofuranyl)quinuclidin-2-ene (1) has been synthesized and evaluated for muscarinic and antimuscarinic properties. The affinity of the compounds was determined by competition experiments in homogenates of cerebral cortex, heart, parotid gland, and urinary bladder from guinea pigs using (-)-[3H]-3-quinuclidinyl benzilate as the radioligand, and the antimuscarinic-potency was determined in a functional assay on isolated guinea pig urinary bladder using carbachol as the agonist. The 5-fluorobenzofuranyl derivative was slightly more potent than 1. The 7-bromo-substituted 8 displayed a 14-fold tissue selectivity ratio for muscarinic receptors in the cortex versus the parotid gland. Comparative molecular field analysis and quantitative structure-activity relationship models were developed for this series of substituted benzofuranyl derivatives.

  8. Inorganic-Organic Thiol-ene Coated Mesh for Oil/Water Separation.

    Science.gov (United States)

    Chen, Qiyi; de Leon, Al; Advincula, Rigoberto C

    2015-08-26

    A highly efficient mesh for oil/water separation was fabricated by using a superhydrophobic and superoleophilic coating of thiol-ene hybrid, consisting of pentaerythritol tetra(3-mercaptopropionate) (PETMP), 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane (TMTVSi), and hydrophobic fumed silica nanoparticles, via a simple two-step fabrication process. Spray deposition and UV curing photopolymerization were sequentially performed, during which solvent evaporation provides microscale roughness while nanoparticle aggregation forms nanoscale roughness. The hierarchical morphologies were stabilized after UV curing photopolymerization. High contact angle (>150°) and low roll-off angle (<5°) were achieved due to the multiscale roughness structure of the hierarchical morphologies. These coatings also have excellent chemical resistance, as well as temperature and pH stability, after curing.

  9. Development of a thiol-ene based screening platform for enzyme immobilization demonstrated using horseradish peroxidase

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Pinelo, Manuel; Woodley, John

    2017-01-01

    Efficient immobilization of enzymes on support surfaces requires an exact match between the surface chemistry and the specific enzyme. A successful match would normally be identified through time consuming screening of conventional resins in multiple experiments testing individual immobilization...... strategies. In this study we present a versatile strategy that largely expands the number of possible surface functionalities for enzyme immobilization in a single, generic platform. The combination of many individual surface chemistries and thus immobilization methods in one modular system permits faster...... functionalization by thiol-ene chemistry (TEC) resulted in the formation of a functional monolayer in each well, whereas, polymer surface grafts were introduced through surface chain transfer free radical polymerization (SCT-FRP). Enzyme immobilization on the modified surfaces was evaluated by using a rhodamine...

  10. Amino acid-incorporated polymer network by thiol-ene polymerization

    Directory of Open Access Journals (Sweden)

    R. Yokose

    2015-08-01

    Full Text Available Triallyl L-alanine (A3A and triallyl L-phenylalanine (A3F were synthesized by reactions of L-alanine and L-phenylalanine with allyl bromide in the presence of sodium hydroxide, respectively. Thiol-ene thermal polymerization of A3A or A3F with pentaerythritol-based primary tetrathiol (pS4P or pentaerythritol-based secondary tetrathiol (S4P at allyl/SH 1/1 in the presence of 2,2'-azobis(isobutyronitrile produced an amino acid-incorporated polymer network (A3ApS4P, A3A-S4P or A3F-S4P. Although the thermally cured resins were homogeneous and flat films, the corresponding thiol-ene photopolymerization did not give a successful result. Degree of swelling for each thermally cured film in N,Ndimethylformamide was much higher than that in water. The glass transition and 5% weight loss temperatures (Tg and T5 of A3F-pS4P and A3F-S4P were higher than those of A3A-pS4P and A3A-S4P, respectively. Also, A3F-pS4P and A3F-S4P exhibited much higher tensile strengths and moduli than A3A-pS4P and A3A-S4P did, respectively. Consequently, A3FpS4P displayed the highest Tg (38.7°C, T5 (282.0°C, tensile strength (9.5 MPa and modulus (406 MPa among all the thermally cured resins.

  11. Hydrophobic thiol-ene surfaces fabricated via plasma activation and photo polymerization

    Science.gov (United States)

    Champathet, P.; Ervithayasuporn, V.; Osotchan, T.; Dangtip, S.

    2017-09-01

    Alumina, such as glazed alumina for electrical insulator, operated in an open field subjects to a very harsh condition; resulting in lifetime shortening. Coating hydrophobic layer on alumina surface can help prolonging its lifetime. In this study, 25 ×25 mm alumina sheets were used as substrates. The hydrophobic composite polymers were prepared from (3-mercaptopropyl)trimethoxysilane(MPTMS), 2,4,6,8-tetramethyl-2,4,6,8tetravinylcyclotetra siloxane(TMTVSi), pentaerythritoltetra(3-mercaptopropionate)(PETMP), 2,2-dimethoxy-2-phe nylaceto phenone(photoinitiator) and heptadecafluorodecylmethacrylate(HEFDMA) via the thiol-ene reaction. The alumina sheets were first activated by dielectric-barrier discharge plasma to improve its adhesion. All the polymers were found to optimize at the ratio of (MPTMS:TMTVSi:PETMP:HDFDMA) to 4:2:1:2 for coating on the alumina substrate. To enhance polymerization, 2,2-dimethoxy-2-phenylaceto phenome was also used as a photoinitiator A proper mixing sequence in the thiol-ene reaction results in film with excellent surface retention after prolong soaking in solvent such as acetone. FTIR shows that S-H and C=C functional groups have significantly changed after photopolymerization and thermally cured. The static contact angle increase from mere 53.0°±1.5° of the uncoated substrate to 120.0°±1.2° after coating. SEM shows the film with clear appearance of a few-micron thick. Under AFM, the coated surface roughness was about 9.3 nm with evenly distributed spikes of a few nanometer in height. The cross-cut test also confirmed the film was very smooth and none of the square of the films detached.

  12. Hydrophobic Coatings by Thiol-Ene Click Functionalization of Silsesquioxanes with Tunable Architecture.

    Science.gov (United States)

    Dirè, Sandra; Bottone, Davide; Callone, Emanuela; Maniglio, Devid; Génois, Isabelle; Ribot, François

    2017-08-08

    The hydrolysis-condensation of trialkoxysilanes under strictly controlled conditions allows the production of silsesquioxanes (SSQs) with tunable size and architecture ranging from ladder to cage-like structures. These nano-objects can serve as building blocks for the preparation of hybrid organic/inorganic materials with selected properties. The SSQs growth can be tuned by simply controlling the reaction duration in the in situ water production route (ISWP), where the kinetics of the esterification reaction between carboxylic acids and alcohols rules out the extent of organosilane hydrolysis-condensation. Tunable SSQs with thiol functionalities (SH-NBBs) are suitable for further modification by exploiting the simple thiol-ene click reaction, thus allowing for modifying the wettability properties of derived coatings. In this paper, coatings were prepared from SH-NBBs with different architecture onto cotton fabrics and paper, and further functionalized with long alkyl chains by means of initiator-free UV-induced thiol-ene coupling with 1-decene (C10) and 1-tetradecene (C14). The coatings appeared to homogeneously cover the natural fibers and imparted a multi-scale roughness that was not affected by the click functionalization step. The two-step functionalization of cotton and paper warrants a stable highly hydrophobic character to the surface of natural materials that, in perspective, suggests a possible application in filtration devices for oil-water separation. Furthermore, the purification of SH-NBBs from ISWP by-products was possible during the coating process, and this step allowed for the fast, initiator-free, click-coupling of purified NBBs with C10 and C14 in solution with a nearly quantitative yield. Therefore, this approach is an alternative route to get sol-gel-derived, ladder-like, and cage-like SSQs functionalized with long alkyl chains.

  13. Fabrication of antibody-loaded microgels using microfluidics and thiol-ene photoclick chemistry.

    Science.gov (United States)

    Gregoritza, Manuel; Abstiens, Kathrin; Graf, Moritz; Goepferich, Achim M

    2018-06-01

    Reducing burst effects, providing controlled release, and safeguarding biologics against degradation are a few of several highly attractive applications for microgels in the field of controlled release. However, the incorporation of proteins into microgels without impairing stability is highly challenging. In this proof of concept study, the combination of microfluidics and thiol-ene photoclick chemistry was evaluated for the fabrication of antibody-loaded microgels with narrow size distribution. Norbornene-modified eight-armed poly(ethylene glycol) with an average molecular mass of 10,000 Da, 20,000 Da, or 40,000 Da were prepared as macromonomers for microgel formation. For functionalization, either hydrolytically cleavable ester or stable amide bonds were used. A microfluidic system was employed to generate precursor solution droplets containing macromonomers, the cross-linker dithiothreitol and the initiator Eosin-Y. Irradiation with visible light was used to trigger thiol-ene reactions which covalently cross-linked the droplets. For all bond-types, molecular masses, and concentrations gelation was very rapid (<20 s) and a plateau for the complex shear modulus was reached after only 5 min. The generated microgels had a rod-like shape and did not show considerable cellular toxicity. Stress conditions during the fabrication process were simulated and it could be shown that fabrication did not impair the activity of the model proteins lysozyme and bevacizumab. It was confirmed that the average hydrogel network mesh size was similar or smaller than the hydrodynamic diameter of bevacizumab which is a crucial factor for restricting diffusion and delaying release. Finally, microgels were loaded with bevacizumab and a sustained release over a period of 30 ± 4 and 47 ± 7 days could be achieved in vitro. Copyright © 2018 Elsevier B.V. All rights reserved.

  14. Ene-yne Cross-Metathesis for the Preparation of 2,3-Diaryl-1,3-dienes

    Directory of Open Access Journals (Sweden)

    Meriem K. Abderrezak

    2017-11-01

    Full Text Available Ene-yne cross-metathesis from alkynes and ethylene is a useful method to produce substituted conjugated butadiene derivatives. If this method has been used with aliphatic alkynes, it has however never been used starting from diarylacetylenes as internal alkynes. We show that the ene-yne cross-metathesis catalyzed by the second generation Hoveyda ruthenium catalyst provides the 2,3-diarylbuta-1,3-dienes under 3 atm of ethylene at 100 °C. The scope and limitations of the reaction have been evaluated starting from unsymmetrical functionalized diarylacetylene derivatives hence leading to unsymmetrical 2,3-diarylbuta-1,3-dienes in a straightforward and environmentally acceptable manner.

  15. Emplazamiento hacia el ENE del manto de Los Reales (Alpujarrides occidentales: criterios estructurales y de petrofábrica

    Directory of Open Access Journals (Sweden)

    Tubía, J. M.

    1984-08-01

    Full Text Available Los Reales nappe rests over Ojén nappe to the North of Sierra Alpujata. The nappe contact zone shows a intense plastic deformation with mylonitic rocks, The deformation decreases progressively going away from the contacto The structural study of footwall and hangingwall roen permits to attribute this deformation to the Los Reales nappe emplacement over that of Ojén. The foliation and stretching lineation distributions show a WSW-ENE shear direction. The mylonite microstructural characteristics and the enstatite crystalline preferred orientations in the basal peridotites give a mear sense in according that, Los Reales nappe is displaced, in their present position, from the WSW towards the ENE.

    El manto de Los Reales descansa sobre el manto de Ojén, al norte de Sierra Alpujata. La zona de contacto entre mantos exhibe una intensa deformación plástica con rocas miloníticas; la deformación disminuye progresivamente al alejarse del contacto. El estudio estructural de las rocas infra y suprayacentes al contacto permite atribuir esta deformación al emplazamiento del manto de Los Reales sobre el de Ojén. , Las distribuciones de la foliación y de la lineación, de estiramiento indican una dirección de cizallamiento WSW-ENE. Las características microestructurales de las milonitas y las orientaciones preferentes cristalinas de la enstatita en las peridotitas basales proporcionan un sentido de cizallamiento tal que el manto de Los Reales se ha desplazado, en su posición actual, desde el WSW hacia el ENE.

  16. ENED-GEM: A Conceptual Framework Model for Psychological Enjoyment Factors and Learning Mechanisms in Educational Games about the Environment

    Science.gov (United States)

    Fjællingsdal, Kristoffer S.; Klöckner, Christian A.

    2017-01-01

    Based on a thorough review of psychological literature, this article seeks to develop a model of game enjoyment and environmental learning (ENvironmental EDucational Game Enjoyment Model, ENED-GEM) and delineate psychological processes that might facilitate learning and inspire behavioral change from educational games about the environment. A critically acclaimed digital educational game about environmental issues (Fate of the World by Red Redemption/Soothsayer Games) was used as a case study. Two hundred forty-nine reviews of the game from the popular gaming and reviewing platform known as Steam were analyzed by means of a thematic content analysis in order to identify key player enjoyment factors believed to be relevant to the process of learning from games, as well as to gain an understanding of positive and negative impressions about the game’s general content. The end results of the thematic analysis were measured up to the suggested ENED-GEM framework. Initial results generally support the main elements of the ENED-GEM, and future research into the importance of these individual core factors is outlined. PMID:28701988

  17. ENED-GEM: A Conceptual Framework Model for Psychological Enjoyment Factors and Learning Mechanisms in Educational Games about the Environment

    Directory of Open Access Journals (Sweden)

    Kristoffer S. Fjællingsdal

    2017-06-01

    Full Text Available Based on a thorough review of psychological literature, this article seeks to develop a model of game enjoyment and environmental learning (ENvironmental EDucational Game Enjoyment Model, ENED-GEM and delineate psychological processes that might facilitate learning and inspire behavioral change from educational games about the environment. A critically acclaimed digital educational game about environmental issues (Fate of the World by Red Redemption/Soothsayer Games was used as a case study. Two hundred forty-nine reviews of the game from the popular gaming and reviewing platform known as Steam were analyzed by means of a thematic content analysis in order to identify key player enjoyment factors believed to be relevant to the process of learning from games, as well as to gain an understanding of positive and negative impressions about the game’s general content. The end results of the thematic analysis were measured up to the suggested ENED-GEM framework. Initial results generally support the main elements of the ENED-GEM, and future research into the importance of these individual core factors is outlined.

  18. ENED-GEM: A Conceptual Framework Model for Psychological Enjoyment Factors and Learning Mechanisms in Educational Games about the Environment.

    Science.gov (United States)

    Fjællingsdal, Kristoffer S; Klöckner, Christian A

    2017-01-01

    Based on a thorough review of psychological literature, this article seeks to develop a model of game enjoyment and environmental learning (ENvironmental EDucational Game Enjoyment Model, ENED-GEM) and delineate psychological processes that might facilitate learning and inspire behavioral change from educational games about the environment. A critically acclaimed digital educational game about environmental issues (Fate of the World by Red Redemption/Soothsayer Games) was used as a case study. Two hundred forty-nine reviews of the game from the popular gaming and reviewing platform known as Steam were analyzed by means of a thematic content analysis in order to identify key player enjoyment factors believed to be relevant to the process of learning from games, as well as to gain an understanding of positive and negative impressions about the game's general content. The end results of the thematic analysis were measured up to the suggested ENED-GEM framework. Initial results generally support the main elements of the ENED-GEM, and future research into the importance of these individual core factors is outlined.

  19. Spray-deposition and photopolymerization of organic-inorganic thiol-ene resins for fabrication of superamphiphobic surfaces.

    Science.gov (United States)

    Xiong, Li; Kendrick, Laken L; Heusser, Hannele; Webb, Jamie C; Sparks, Bradley J; Goetz, James T; Guo, Wei; Stafford, Christopher M; Blanton, Michael D; Nazarenko, Sergei; Patton, Derek L

    2014-07-09

    Superamphiphobic surfaces, exhibiting high contact angles and low contact angle hysteresis to both water and low surface tension liquids, have attracted a great deal attention in recent years because of the potential of these materials in practical applications such as liquid-resistant textiles, self-cleaning surfaces, and antifouling/anticorrosion coatings. In this work, we present a simple strategy for fabricating of superamphiphobic coatings based on photopolymerization of hybrid thiol-ene resins. Spray-deposition and UV photopolymerization of thiol-ene resins containing hydrophobic silica nanoparticles and perfluorinated thiols provide a multiscale topography and low-energy surface that endows the surface with superamphiphobicity. The wettability and chemical composition of the surfaces were characterized by contact-angle goniometry and X-ray photoelectron spectroscopy, respectively. The hierarchical roughness features of the thiol-ene surfaces were investigated with field-emission scanning electron microscopy. Droplet impact and sandpaper abrasion tests indicate the coatings respectively possess a robust antiwetting behavior and good mechanical durability.

  20. Iron complexes of tetramine ligands catalyse allylic hydroxyamination via a nitroso–ene mechanism

    Directory of Open Access Journals (Sweden)

    David Porter

    2015-12-01

    Full Text Available Iron(II complexes of the tetradentate amines tris(2-pyridylmethylamine (TPA and N,N′-bis(2-pyridylmethyl-N,N′-dimethylethane-1,2-diamine (BPMEN are established catalysts of C–O bond formation, oxidising hydrocarbon substrates via hydroxylation, epoxidation and dihydroxylation pathways. Herein we report the capacity of these catalysts to promote C–N bond formation, via allylic amination of alkenes. The combination of N-Boc-hydroxylamine with either FeTPA (1 mol % or FeBPMEN (10 mol % converts cyclohexene to the allylic hydroxylamine (tert-butyl cyclohex-2-en-1-yl(hydroxycarbamate in moderate yields. Spectroscopic studies and trapping experiments suggest the reaction proceeds via a nitroso–ene mechanism, with involvement of a free N-Boc-nitroso intermediate. Asymmetric induction is not observed using the chiral tetramine ligand (+-(2R,2′R-1,1′-bis(2-pyridylmethyl-2,2′-bipyrrolidine ((R,R′-PDP.

  1. Inspection and monitoring plan, contaminated groundwater seeps 317/319/ENE Area, Argonne National Laboratory

    International Nuclear Information System (INIS)

    1996-01-01

    During the course of completing the Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI) in the 317/319/East-Northeast (ENE) Area of Argonne National Laboratory-East (ANL-E), groundwater was discovered moving to the surface through a series of groundwater seeps. The seeps are located in a ravine approximately 600 ft south of the ANL-E fence line in Waterfall Glen Forest Preserve. Samples of the seep water were collected and analyzed for selected parameters. Two of the five seeps sampled were found to contain detectable levels of organic contaminants. Three chemical species were identified: chloroform (14--25 microg/L), carbon tetrachloride (56--340 microg/L), and tetrachloroethylene (3--6 microg/L). The other seeps did not contain detectable levels of volatile organics. The nature of the contaminants in the seeps will also be monitored on a regular basis. Samples of surface water flowing through the bottom of the ravine and groundwater emanating from the seeps will be collected and analyzed for chemical and radioactive constituents. The results of the routine sampling will be compared with the concentrations used in the risk assessment. If the concentrations exceed those used in the risk assessment, the risk calculations will be revised by using the higher numbers. This revised analysis will determine if additional actions are warranted

  2. Photolithographic fabrication of solid–liquid core waveguides by thiol-ene chemistry

    International Nuclear Information System (INIS)

    Sagar, Kaushal; Gopalakrishnan, Nimi; Christiansen, Mads Brøkner; Kristensen, Anders; Ndoni, Sokol

    2011-01-01

    In this work we demonstrate an efficient and cleanroom compatible method for the fabrication of solid–liquid core waveguides based on nanoporous polymers. We have used thiol-ene photo-grafting to tune and pattern the hydrophilicity of an originally hydrophobic nanoporous 1, 2-polybutadiene. The generated refractive index contrast between the patterned water-filled volume and the surrounding empty hydrophobic porous polymer allows for light confinement within the water-filled volume—the solid–liquid core. The presented fabrication process is simple and fast. It allows a high degree of flexibility on the type and grade of surface chemistry imparted to the large nanoporous area depending upon the application. The fabrication does not need demanding chemical reaction conditions. Thus, it can be readily used on a standard silicon lithography bench. The propagation loss values reported in this work are comparable with literature values for state-of-the-art liquid-core waveguide devices. The demonstrated waveguide function added to the nanoporous polymer with a very high internal surface area makes the system interesting for many applications in different areas, such as diagnostics and bio-chemical sensing

  3. Superhydrophobic and Slippery Lubricant-Infused Flexible Transparent Nanocellulose Films by Photoinduced Thiol-Ene Functionalization.

    Science.gov (United States)

    Guo, Jiaqi; Fang, Wenwen; Welle, Alexander; Feng, Wenqian; Filpponen, Ilari; Rojas, Orlando J; Levkin, Pavel A

    2016-12-14

    Films comprising nanofibrillated cellulose (NFC) are suitable substrates for flexible devices in analytical, sensor, diagnostic, and display technologies. However, some major challenges in such developments include their high moisture sensitivity and the complexity of current methods available for functionalization and patterning. In this work, we present a facile process for tailoring the surface wettability and functionality of NFC films by a fast and versatile approach. First, the NFC films were coated with a layer of reactive nanoporous silicone nanofilament by polycondensation of trichlorovinylsilane (TCVS). The TCVS afforded reactive vinyl groups, thereby enabling simple UV-induced functionalization of NFC films with various thiol-containing molecules via the photo "click" thiol-ene reaction. Modification with perfluoroalkyl thiols resulted in robust superhydrophobic surfaces, which could then be further transformed into transparent slippery lubricant-infused NFC films that displayed repellency against both aqueous and organic liquids with surface tensions as low as 18 mN·m -1 . Finally, transparent and flexible NFC films incorporated hydrophilic micropatterns by modification with OH, NH 2 , or COOH surface groups, enabling space-resolved superhydrophobic-hydrophilic domains. Flexibility, transparency, patternability, and perfect superhydrophobicity of the produced nanocellulose substrates warrants their application in biosensing, display protection, and biomedical and diagnostics devices.

  4. Polysiloxane-based luminescent elastomers prepared by thiol-ene "click" chemistry.

    Science.gov (United States)

    Zuo, Yujing; Lu, Haifeng; Xue, Lei; Wang, Xianming; Wu, Lianfeng; Feng, Shengyu

    2014-09-26

    Side-chain vinyl poly(dimethylsiloxane) has been modified with mercaptopropionic acid, methyl 3-mercaptopropionate, and mercaptosuccinic acid. Coordinative bonding of Eu(III) to the functionalized polysiloxanes was then carried out and crosslinked silicone elastomers were prepared by thiol-ene curing reactions of these composites. All these europium complexes could be cast to form transparent, uniform, thin elastomers with good flexibility and thermal stability. The networks were characterized by FTIR, NMR, UV/Vis, and luminescence spectroscopy as well as by scanning electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy. The europium elastomer luminophores exhibited intense red light at 617 nm under UV excitation at room temperature due to the (5)D0 →(7)F2 transition in Eu(III) ions. The newly synthesized luminescent materials offer many advantages, including the desired mechanical flexibility. They cannot be dissolved or fused, and so they have potential for use in optical and electronic applications. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Chalcogenidobis(ene-1,2-dithiolate)molybdenum(IV) complexes (chalcogenide E = O, S, Se): probing Mo≡E and ene-1,2-dithiolate substituent effects on geometric and electronic structure.

    Science.gov (United States)

    Sugimoto, Hideki; Tano, Hiroyuki; Suyama, Koichiro; Kobayashi, Tomoya; Miyake, Hiroyuki; Itoh, Shinobu; Mtei, Regina P; Kirk, Martin L

    2011-02-07

    New square-pyramidal bis(ene-1,2-dithiolate)MoSe complexes, [Mo(IV)Se(L)(2)](2-), have been synthesised along with their terminal sulfido analogues, [Mo(IV)S(L)(2)](2-), using alkyl (L(C(4)H(8))), phenyl (L(Ph)) and methyl carboxylate (L(COOMe)) substituted dithiolene ligands (L). These complexes now complete three sets of Mo(IV)O, Mo(IV)S and Mo(IV)Se species that are coordinated with identical ene-1,2-dithiolate ligands. The [alkyl substituted Mo(S/Se)(L(C(4)H(8)))(2)](2-) complexes were reported in prior investigations (H. Sugimoto, T. Sakurai, H. Miyake, K. Tanaka and H. Tsukube, Inorg. Chem. 2005, 44, 6927, H. Tano, R. Tajima, H. Miyake, S. Itoh and H. Sugimoto, Inorg. Chem. 2008, 47, 7465). The new series of complexes enable a systematic investigation of terminal chalcogenido and supporting ene-1,2-dithiolate ligand effects on geometric structure, electronic structure, and spectroscopic properties. X-ray crystallographic analysis of these (Et(4)N)(2)[MoEL(2)] (E = terminal chalocogenide) complexes reveals an isostructural Mo centre that adopts a distorted square pyramidal geometry. The M≡E bond distances observed in the crystal structures and the ν(M≡E) vibrational frequencies indicate that these bonds are weakened with an increase in L→Mo electron donation (L(COOMe) < L(Ph) < L(C(4)H(8))), and this order is confirmed by an electrochemical study of the complexes. The (77)Se NMR resonances in MoSeL complexes appear at lower magnetic fields as the selenido ion became less basic from MoSeL(C(4)H(8)), MoSeL(Ph) and MoSeL(COOMe). Electronic absorption and resonance Raman spectroscopies have been used to assign key ligand-field, MLCT, LMCT and intraligand CT bands in complexes that possess the L(COOMe) ligand. The presence of low-energy intraligand CT transition in these MoEL(COOMe) compounds directly probes the electron withdrawing nature of the -COOMe substituents, and this underscores the complex electronic structure of square pyramidal bis(ene-1

  6. Synthesis and Transformations of di-endo-3-Aminobicyclo-[2.2.2]oct-5-ene-2-carboxylic Acid Derivatives

    Directory of Open Access Journals (Sweden)

    Márta Palkó

    2011-09-01

    Full Text Available all-endo-3-amino-5-hydroxybicyclo[2.2.2]octane-2-carboxylic acid (13 and all-endo-5-amino-6-(hydroxymethylbicyclo[2.2.2]octan-2-ol (10 were prepared via dihydro-1,3-oxazine or g-lactone intermediates by the stereoselective functionalization of an N-protected derivative of endo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acid (2. Ring closure of b-amino ester 4 resulted in tricyclic pyrimidinones 15 and 16. The structures, stereochemistry and relative configurations of the synthesized compounds were determined by IR and NMR.

  7. Vabariigi presidendi, riigikogu esimehe ja peaministri ühisavaldus 8. mail 2007 / Toomas Hendrik Ilves, Ene Ergma, Andrus Ansip

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2007-01-01

    President Toomas Hendrik Ilvese, Riigikogu spiikri Ene Ergma ja peaminister Andrus Ansipi avaldus Teise maailmasõja lõpu 62. aastapäeva puhul. Ilmunud ka: Severnoje Poberežje 9. mai 2007, lk. 2; Eesti Elu 11. mai 2007, lk. 2, pealk.: Riigijuhtide ühisavaldus Teise maailmasõja mälestuspäeval, ingl. k. lk. 11, pealk.: Joint statement May 8, 2007; ingl. k. Vaba Eesti Sõna 10. mai 2007, lk. 12, pealk.: Joint statement of the President, Speaker of the Parliament and Prime Minister of the Republic of Estonia

  8. Selective fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene by nucleotides.

    Science.gov (United States)

    Marquez, Cesar; Pischel, Uwe; Nau, Werner M

    2003-10-16

    [reaction: see text] The fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by nucleotides has been studied. The quenching mechanism was analyzed on the basis of deuterium isotope effects, tendencies for exciplex formation, and the quenching efficiency in the presence of a molecular container (cucurbit[7]uril). Exciplex-induced quenching appears to prevail for adenosine, cytidine, and uridine, while hydrogen abstraction becomes competitive for thymidine and guanosine. Compared to other fluorescent probes, DBO responds very selectively to the type of nucleotide.

  9. Stereoselectivity in ene reactions with 1O2: matrix effects in polymer supports, photo-oxygenation of organic salts and asymmetric synthesis.

    Science.gov (United States)

    Griesbeck, Axel G; Bartoschek, Anna; Neudörfl, Jörg; Miara, Claus

    2006-01-01

    The ene reaction of chiral allylic alcohols is applied as a tool for the investigation of intrapolymer effects by means of the stereoselectivity of the singlet-oxygen addition. The diastereo selectivity strongly depends on the structure of the polymer, the substrate loading degree and also on the degree of conversion demonstrating additional supramolecular effects evolving during the reaction. The efficiency and the stability of polymer-bound sensitizers were evaluated by the ene reaction of singlet oxygen with citronellol. The ene reaction with chiral ammonium salts of tiglic acid was conducted under solution phase conditions or in polystyrene beads under chiral contact ion-pair conditions. The products thus obtained precipitate during the photoreaction as ammonium salts. Moderate asymmetric induction was observed for this procedure for the first time.

  10. Evaluation of fracture toughness and mechanical properties of ternary thiol-ene-methacrylate systems as resin matrix for dental restorative composites.

    Science.gov (United States)

    Beigi, Saeed; Yeganeh, Hamid; Atai, Mohammad

    2013-07-01

    Study and evaluation of fracture toughness, flexural and dynamic mechanical properties, and crosslink density of ternary thiol-ene-methacrylate systems and comparison with corresponding conventional methacrylate system were considered in the present study. Urethane tetra allyl ether monomer (UTAE) was synthesized as ene monomer. Different formulations were prepared based on combination of UTAE, BisGMA/TEGDMA and a tetrathiol monomer (PETMP). The photocuring reaction was conducted under visible light using BD/CQ combination as photoinitiator system. Mechanical properties were evaluated via measuring flexural strength, flexural modulus and fracture toughness. Scanning electron microscopy (SEM) was utilized to study the morphology of the fractured specimen's cross section. Viscoelastic properties of the samples were also determined by dynamic mechanical thermal analysis (DMTA). The same study was performed on a conventional methacrylate system. The data were analyzed and compared by ANOVA and Tukey HSD tests (significance level=0.05). The results showed improvement in fracture toughness of the specimens containing thiol-ene moieties. DMTA revealed a lower glass transition temperature and more homogenous structure for thiol-ene containing specimens in comparison to the system containing merely methacrylate monomer. The flexural modulus and flexural strength of the specimens with higher thiol-ene content were lower than the neat methacrylate system. The SEM micrographs of the fractured surface of specimens with higher methacrylate content were smooth and mirror-like (shiny) which represent brittle fracture. The thiol-ene-methacrylate system can be used as resin matrix of dental composites with enhanced fracture toughness in comparison to the methacrylate analogous. Copyright © 2013 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  11. Thiol-ene and photo-cleavage chemistry for controlled presentation of biomolecules in hydrogels.

    Science.gov (United States)

    Grim, Joseph C; Marozas, Ian A; Anseth, Kristi S

    2015-12-10

    photochemical methods have led to important advances in the tissue regeneration community, namely the thiol-ene photo-click reaction for bioconjugation and photocleavage reactions that allow for the removal of protecting groups. Specific examples will be highlighted where these methodologies have been used to engineer hydrogels that control and direct cell function with the aim of inspiring their use in regenerative medicine. Copyright © 2015 Elsevier B.V. All rights reserved.

  12. Stavovi medicinskih sestara u Hrvatskoj o primarnom oživljavanju prijevremeno rođene novorođenčadi

    OpenAIRE

    Bilić, Iva; Prpić, Igor; Radić, Jelena; Vukelić, Petar; Petrović, Ana; Juretić, Emilija; Furlan, Ivanka

    2008-01-01

    CILJ: Cilj istraživanja bilo je ispitati stavove medicinskih sestara u Hrvatskoj o primarnom oživljavanju prijevremeno rođene djece. METODE: Pisanom anketom ispitivana je dob, roditeljstvo, radno iskustvo i mjesto rada te stavovi medicinskih sestara iz Hrvatske o primarnom oživljavanju prijevremeno rođene djece. Anketirano je 174 medicinskih sestara; 49 zaposlenih u rađaonici ili na mjestima rada sa trudnicama (Rađ/Tr), 79 u pedijatrijskim/ neonatološkim jedinicama intenzivnog liječenja (...

  13. Investigation of curing rates of bio-based thiol-ene films from diallyl 2,5-furandicaboxylate

    DEFF Research Database (Denmark)

    Larsen, Daniel Bo; Sønderbæk-Jørgensen, Rene; Duus, Jens Ø.

    2018-01-01

    The bio-based monomer, 2,5-furandicarboxylic acid, has been adapted to classic thiol-ene chemistry by derivatization of the acid with allyl alcohol. This new monomer has allowed for the synthesis of new thermoset systems, capable of forming green, sustainable materials through UV-crosslinking. In......The bio-based monomer, 2,5-furandicarboxylic acid, has been adapted to classic thiol-ene chemistry by derivatization of the acid with allyl alcohol. This new monomer has allowed for the synthesis of new thermoset systems, capable of forming green, sustainable materials through UV......-crosslinking. In this study, the synthesis of the new monomer along with thorough kinetic studies of the new thermoset systems are presented. In order to determine kinetic values for the systems, all reactions have been followed by real-time FT-IR. Initially, a study of three different photoinitiators is performed...... on a classic TEMPIC-TATATO system, in order to determine the superior initiator for the new systems. The new monomer is crosslinked with five different thiol compounds in both stoichiometric and off-stoichiometric ratios, yielding an array of bio-based thermosets. The properties of these systems are determined...

  14. Thiol-ene click chemistry derived cationic cyclodextrin chiral stationary phase and its enhanced separation performance in liquid chromatography.

    Science.gov (United States)

    Yao, Xiaobin; Tan, Timothy Thatt Yang; Wang, Yong

    2014-01-24

    This work is the first demonstration of a simple thiol-ene click chemistry to anchor vinyl imidazolium β-CD onto thiol silica to form a novel cationic native cyclodextrin (CD) chiral stationary phase (CSP). The CSP afforded high enantioseparation ability towards dansyl (Dns) amino acids, carboxylic aryl compounds and flavonoids in chiral HPLC. The current CSP demonstrates the highest resolving ability (selectivity >1.1, resolution >1.5) towards Dns amino acids in a mobile phase buffered at pH=6.5, with the resolution of Dns-dl-leucine as high as 6.97. 2,4-dichloride propionic acid (2,4-ClPOPA) was well resolved with the selectivity and resolution of 1.37 and 4.88, respectively. Compared to a previously reported native CD-CSP based on a triazole linkage, the current cationic CD-CSP shows a stronger retention and higher resolution towards acidic chiral compounds, ascribed to the propitious strong electrostatic attraction. Stability evaluation results indicated that thiol-ene reaction can provide a facile and robust approach for the preparation of positively charged CD CSPs. Copyright © 2013 Elsevier B.V. All rights reserved.

  15. Functional characterization and stability improvement of a ‘thermophilic-like’ ene-reductase from Rhodococcus opacus 1CP

    Directory of Open Access Journals (Sweden)

    Anika eRiedel

    2015-10-01

    Full Text Available Ene-reductases are widely applied for the asymmetric synthesis of relevant industrial chemicals. A novel ene-reductase OYERo2 was found within a set of 14 putative Old Yellow Enzymes (OYEs obtained by genome mining of the actinobacterium Rhodococcus opacus 1CP. Multiple sequence alignment suggested that the enzyme belongs to the group of ‘thermophilic-like’ OYEs. OYERo2 was produced in Escherichia coli and biochemically characterized. The enzyme is strongly NADPH dependent and uses non-covalently bound FMNH2 for the reduction of activated α,β-unsaturated alkenes. In the active form OYERo2 is a dimer. Optimal catalysis occurs at pH 7.3 and 37 °C. OYERo2 showed highest specific activities (4550 U mg-1 on maleimides, which are efficiently converted to the corresponding succinimides. The OYERo2-mediated reduction of prochiral alkenes afforded the (R-products with excellent optical purity (ee > 99%. OYERo2 is not as thermo-resistant as related OYEs. Introduction of a characteristic intermolecular salt bridge by site-specific mutagenesis raised the half-life of enzyme inactivation at 32 °C from 28 min to 87 min and improved the tolerance towards organic co-solvents. The suitability of OYERo2 for application in industrial biocatalysis is discussed.

  16. Biocatalysis with thermostable enzymes: structure and properties of a thermophilic 'ene'-reductase related to old yellow enzyme.

    Science.gov (United States)

    Adalbjörnsson, Björn V; Toogood, Helen S; Fryszkowska, Anna; Pudney, Christopher R; Jowitt, Thomas A; Leys, David; Scrutton, Nigel S

    2010-01-25

    We report the crystal structure of a thermophilic "ene" reductase (TOYE) isolated from Thermoanaerobacter pseudethanolicus E39. The crystal structure reveals a tetrameric enzyme and an active site that is relatively large compared to most other structurally determined and related Old Yellow Enzymes. The enzyme adopts higher order oligomeric states (octamers and dodecamers) in solution, as revealed by sedimentation velocity and multiangle laser light scattering. Bead modelling indicates that the solution structure is consistent with the basic tetrameric structure observed in crystallographic studies and electron microscopy. TOYE is stable at high temperatures (T(m)>70 degrees C) and shows increased resistance to denaturation in water-miscible organic solvents compared to the mesophilic Old Yellow Enzyme family member, pentaerythritol tetranitrate reductase. TOYE has typical ene-reductase properties of the Old Yellow Enzyme family. There is currently major interest in using Old Yellow Enzyme family members in the preparative biocatalysis of a number of activated alkenes. The increased stability of TOYE in organic solvents is advantageous for biotransformations in which water-miscible organic solvents and biphasic reaction conditions are required to both deliver novel substrates and minimize product racemisation.

  17. (E-2-((4R,5R-5-((Benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-ylbut-2-ene-1,4-diol

    Directory of Open Access Journals (Sweden)

    Carlos R. Carreras

    2010-04-01

    Full Text Available The synthesis of (E-2-((4R,5R-5-((benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-ylbut-2-ene-1,4-diol by a one-step reduction of the appropriate 2-substituted butenolide is reported. Product characterization was carried out by IR, 1H NMR, 13C NMR, MS, elemental analysis and optical rotation.

  18. Kui oluliseks isikuandmete kaitsmist kooli oludes peate ja millest seda tehes lähtute? / Harri Kõo, Ene Tannberg, Kalle Niinas, Maria Tiro...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad Tabasalu Ühisgümnaasiumi direktor Harri Kõo, Tartu Miina Härma Gümnaasiumi direktor Ene Tannberg, Jakob Westholmi Gümnaasiumi direktor Kalle Niinas, Jüri Gümnaasiumi direktor Maria Tiro ja Viimsi Keskkooli direktor Leelo Tiisvelt

  19. Katkenud õpingute teise kõrgkooli "kolimine" nõuab visadust / Agne Narusk, Ene Küüner, Heli Mattisen, Kadri Osula

    Index Scriptorium Estoniae

    Narusk, Agne

    2007-01-01

    Pooleli jäänud ülikooliõpingute lõpetamisest. Varasemate õpingute ja töökogemuse arvestamise tingimusi õpingute jätkamisel selgitavad Tartu Ülikooli avatud ülikooli tasemeõppe koordinaator Ene Küüner, Tallinna Ülikooli akadeemiline prorektor Heli Mattisen ja Estonian Business Schoolì õppeosakonna juhataja Kadri Osula

  20. Ene-Liis Semper: selle aasta puhkepäevad võib ühe käe sõrmedel kokku lugeda

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2011-01-01

    Tallinna kultuuripealinna projekti panustanud Ene-Liis Semper võtab 2011. aasta sündmused kokku ja selgitab, kuidas jõudsid publiku ette suurlavastused "The Rise and Fall of Estonia", "Three Kingdoms", Põhuteater ning isikunäitus Kumus

  1. Joint statement of the President, Speaker of the Riigikogu and Prime Minister of the Republic of Estonia / Toomas Hendrik Ilves, Ene Ergma, Andrus Ansip

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    President Toomas Hendrik Ilvese, Riigikogu spiikri Ene Ergma ja peaminister Andrus Ansipi ühisavaldus Teise maailmasõja lõpu 62. aastapäeva puhul 8. mail 2007, milles kinnitatakse, et hoolimata Teise maailmasõja ajaloolistest tõlgendustest on kõik Eestis elavad inimesed vabad ning jagavad ühist tulevikku

  2. One-step fabrication of PEGylated fluorescent nanodiamonds through the thiol-ene click reaction and their potential for biological imaging

    Science.gov (United States)

    Huang, Hongye; Liu, Meiying; Tuo, Xun; Chen, Junyu; Mao, Liucheng; Wen, Yuanqing; Tian, Jianwen; Zhou, Naigen; Zhang, Xiaoyong; Wei, Yen

    2018-05-01

    Over the past years, fluorescent carbon nanoparticles have got growing interest for biological imaging. Fluorescent nanodiamonds (FNDs) are novel fluorescent carbon nanoparticles with multitudinous useful properties, including remarkable fluorescence properties, extremely low toxicity and high refractive index. However, facile preparation of FNDs with designable properties and functions from non-fluorescent detonation nanodiamonds (DNDs) has demonstrated to be challengeable. In this work, we reported for the first time that preparation of Polyethylene glycol (PEG) functionalized FNDs through a one-step thiol-ene click reaction using thiol containing PEG (PEG-SH) as the coating agent. Based on the characterization results, we demonstrated that PEG-SH could be efficiently introduced on DNDs to obtain FNDs through the thiol-ene click chemistry. The resultant FND-PEG composites showed high water dispersibility, strong fluorescence and low cytotoxicity. Moreover, FND-PEG composites could be internalized by cells and displayed good cell dyeing performance. All of these features implied that FND-PEG composites are of great potential for biological imaging. Taken together, a facile one-step strategy based on the one-step thiol-ene click reaction has been developed for efficient preparation of FND-PEG composites from non-fluorescent DNDs. The strategy should be also useful for fabrication of many other functional FNDs via using different thiol containing compounds for the universality of thiol-ene click reaction.

  3. A neutral polyacrylate copolymer coating for surface modification of thiol-ene microchannels for improved performance of protein separation by microchip electrophoresis

    DEFF Research Database (Denmark)

    Mesbah, Kiarach; Mai, T.D.; Jensen, Thomas Glasdam

    2016-01-01

    We have investigated the behavior of thiol-ene substrates that is a class of promising materials for lab-on-a-chip electrophoresis applications. Two polymeric materials were prepared by copolymerization of N, N-dimethylacrylamide (DMA), (3-(methacryloyl-oxy)propyl)trimethoxysilane (PMA) and 3-tri...

  4. Stereochemistry of 16a-Hydroxyfriedelin and 3-Oxo-16-methylfriedel-16-ene Established by 2D NMR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Vagner Fernandes Knupp

    2009-02-01

    Full Text Available Friedelin (1, 3b-friedelinol (2, 28-hydroxyfriedelin (3, 16a-hydroxyfriedelin (4, 30-hydroxyfriedelin (5 and 16a,28-dihydroxyfriedelin (6 were isolated through fractionation of the hexane extract obtained from branches of Salacia elliptica. After a week in CDCl3 solution, 16a-hydroxyfriedelin (4 reacted turning into 3-oxo-16-methylfriedel-16-ene (7. This is the first report of a dehydration followed by a Nametkin rearrangement of a pentacyclic triterpene in CDCl3 solution occurring in the NMR tube. These seven pentacyclic triterpenes was identified through NMR spectroscopy and the stereochemistry of compound 4 and 7 was established by 2D NMR (NOESY spectroscopy and mass spectrometry (GC-MS. It is also the first time that all the 13C-NMR and 2D NMR spectral data are reported for compounds 4 and 7.

  5. Modifying surface resistivity and liquid moisture management property of keratin fibers through thiol-ene click reactions.

    Science.gov (United States)

    Yu, Dan; Cai, Jackie Y; Church, Jeffrey S; Wang, Lijing

    2014-01-22

    This paper reports on a new method for improving the antistatic and liquid moisture management properties of keratinous materials. The method involves the generation of thiols by controlled reduction of cystine disulfide bonds in keratin with tris(2-carboxyethyl) phosphine hydrochloride and subsequent grafting of hydrophilic groups onto the reduced keratin by reaction with an acrylate sulfonate or acrylamide sulfonate through thiol-ene click chemistry. The modified substrates were characterized with Raman spectroscopy and scanning electron microscopy and evaluated for their performance changes in liquid moisture management, surface resistivity, and wet burst strength. The results have revealed that the thiol-acrylate reaction is more efficient than the thiol-acrylamide reaction, and the keratinous substrate modified with an acrylate sulfonate salt exhibits significantly improved antistatic and liquid moisture management properties.

  6. Facile preparation of organic-silica hybrid monolith for capillary hydrophilic liquid chromatography based on "thiol-ene" click chemistry.

    Science.gov (United States)

    Chen, Ming-Luan; Zhang, Jun; Zhang, Zheng; Yuan, Bi-Feng; Yu, Qiong-Wei; Feng, Yu-Qi

    2013-04-05

    In this work, a one-step approach to facile preparation of organic-inorganic hybrid monoliths was successfully developed. After vinyl-end organic monomers and azobisisobutyronitrile (AIBN) were mixed with hydrolyzed tetramethoxysilane (TMOS) and 3-mercaptopropyltrimethoxysilane (MPTMS), the homogeneous mixture was introduced into a fused-silica capillary for simultaneous polycondensation and "thiol-ene" click reaction to form the organic-silica hybrid monoliths. By employing this strategy, two types of organic-silica hybrid monoliths with positively charged quaternary ammonium and amide groups were prepared, respectively. The functional groups were successfully introduced onto the monoliths during the sol-gel process with "thiol-ene" click reaction, which was demonstrated by ζ-potential assessment, energy dispersive X-ray spectroscopy (EDX), and Fourier transform infrared (FT-IR) spectroscopy. The porous structure of the prepared monolithic columns was examined by scanning electron microscopy (SEM), nitrogen adsorption-desorption measurement, and mercury intrusion porosimetry. These results indicate the prepared organic-silica hybrid monoliths possess homogeneous column bed, large specific surface area, good mechanical stability, and excellent permeability. The prepared monolithic columns were then applied for anion-exchange/hydrophilic interaction liquid chromatography. Different types of analytes, including benzoic acids, inorganic ions, nucleosides, and nucleotides, were well separated with high column efficiency around 80,000-130,000 plates/m. Taken together, we present a facile and universal strategy to prepare organic-silica hybrid monoliths with a variety of organic monomers using one-step approach. Copyright © 2013 Elsevier B.V. All rights reserved.

  7. The IS-ENES climate4impact portal: bridging the CMIP5 and CORDEX data to impact users

    Science.gov (United States)

    Som de Cerff, Wim; Plieger, Maarten; Page, Christian; Tatarinova, Natalia; Hutjes, Ronald; de Jong, Fokke; Bärring, Lars; Sjökvist, Elin; Vega Saldarriaga, Manuel; Santiago Cofiño Gonzalez, Antonio

    2015-04-01

    The aim of climate4impact (climate4impact.eu) is to enhance the use of Climate Research Data and to enhance the interaction with climate effect/impact communities. The portal is based on 17 impact use cases from 5 different European countries, and is evaluated by a user panel consisting of use case owners. It has been developed within the IS-ENES European project and is currently operated and further developed in the IS ENES2 project. As the climate impact community is very broad, the focus is mainly on the scientific impact community. Climate4impact is connected to the Earth System Grid Federation (ESGF) nodes containing global climate model data (GCM data) from the fifth phase of the Coupled Model Intercomparison Project (CMIP5) and regional climate model data (RCM) data from the Coordinated Regional Climate Downscaling Experiment (CORDEX). This global network of climate model data centers offers services for data description, discovery and download. The climate4impact portal connects to these services using OpenID, and offers a user interface for searching, visualizing and downloading global climate model data and more. A challenging task is to describe the available model data and how it can be used. The portal informs users about possible caveats when using climate model data. All impact use cases are described in the documentation section, using highlighted keywords pointing to detailed information in the glossary. Climate4impact currently has two main objectives. The first one is to work on a web interface which automatically generates a graphical user interface on WPS endpoints. The WPS calculates climate indices and subset data using OpenClimateGIS/icclim on data stored in ESGF data nodes. Data is then transmitted from ESGF nodes over secured OpenDAP and becomes available in a new, per user, secured OpenDAP server. The results can then be visualized again using ADAGUC WMS. Dedicated wizards for processing of climate indices will be developed in close

  8. Thiol-ene thermosets exploiting surface reactivity for layer-by-layer structures and control of penetration depth for selective surface reactivity

    DEFF Research Database (Denmark)

    Daugaard, Anders Egede; Westh, Andreas; Pereira Rosinha Grundtvig, Ines

    Thiol-ene thermosets have been shown to be an efficient platform for preparation of functional polymer surfaces. Especially the effectiveness and versatility of the system has enabled a large variety of network properties to be obtained in a simple and straight-forward way. Due to its selectivity......, various thiols and allyl or other vinyl reactants can be used to obtain either soft and flexible1 or more rigid functional thermosets 2. The methodology permits use of etiher thermal or photochemical conditions both for matrix preparation as well as for surface functionalization. Due to excess reactive...... groups in thµe surface of thiol-ene thermosets, it is possible to prepare surface functional thermosets or to exploit the reactive groups for modular construction and subsequent chemical bonding. Here a different approach preparing monolithic layer-by-layer structures with controlled mechanical...

  9. Facile synthesis of linear-dendritic cholesteryl-poly(epsilon-caprolactone)-b-(L-lysine)(G2) by thiol-ene and azide-alkyne "click" reactions

    DEFF Research Database (Denmark)

    Javakhishvili, Irakli; Binder, W.H.; Tanner, S.

    2010-01-01

    The construction of a linear-dendritic block copolymer consisting of terminal cholesteryl moiety, poly(epsilon-caprolactone), and a second generation L-lysine dendron has been accomplished by the combination of copper(I) catalyzed azide-alkyne and UV-triggered thiol-ene "click" reactions. Ring-op...... and thiocholesterol. Near to quantitative functionalization of the intermediate and final products has been attained as confirmed by NMR spectroscopy and MALDI-TOF spectrometry....

  10. Cyclohex-1-ene carboxylic acids: synthesis and biological evaluation of novel inhibitors of human 5 alpha reductase.

    Science.gov (United States)

    Baston, Eckhard; Salem, Ola I A; Hartmann, Rolf W

    2003-03-01

    In search of novel nonsteroidal mimics of steroidal inhibitors of 5 alpha reductase, 4-(2-phenylethyl)cyclohex-1-ene carboxylic acids 1-5 were synthesized with different substituents in para position of the phenyl ring (1: N, N-diisopropylcarbamoyl, 2: phenyl, 3: phenoxy, 4: benzoyl, and 5: benzyl). The principal synthetic approach for the desired compounds consisted of a Wittig olefination between 1, 4-dioxaspiro [4.5]-decane-8-carbaldehyde (4g and the appropriate phosphonium salts. The compounds were tested for inhibition of human 5 alpha reductase isozymes 1 and 2 using DU 145 cells and preparations from prostatic tissue, respectively. They turned out to be good inhibitors of the prostatic isozyme 2 with compound 1 being the most potent one (IC(50) = 760 nM). Isozyme 1 was only slightly inhibited. It is concluded that the novel structures are appropriate for being further optimized, aiming at the development of a novel drug for the treatment of benign prostatic hyperplasia.

  11. Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription.

    Science.gov (United States)

    Osorio, Alex A; Muñóz, Alejandro; Torres-Romero, David; Bedoya, Luis M; Perestelo, Nayra R; Jiménez, Ignacio A; Alcamí, José; Bazzocchi, Isabel L

    2012-06-01

    In the present study we report the isolation of nine new olean-18-ene triterpenes (1-9), along with three known ones (10-12), from Cassine xylocarpa and Maytenus jelskii. Their stereostructures have been elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR techniques (COSY, ROESY, HSQC and HMBC), and spectrometric methods. The natural compounds and derivatives 13-15 have been tested for their potential as inhibitors of human immunodeficiency virus type 1 replication. Five compounds from this series displayed potent antiviral activity with IC(50)s in the micromolar range (1, 3, 4, 7 and 8) being 1 and 8 the most active compounds. The target of these compounds was different from antiretroviral drugs currently licensed as they act as inhibitors of enhancer-dependent transcription. The structure-activity relationships were established based on the regiosubstitution and oxidation degree of the triterpene scaffold, revealing that these aspects were able to modulate the selectivity and intensity of HIV inhibition. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  12. Investigations on the fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene by certain flavonoids.

    Science.gov (United States)

    Anbazhagan, V; Kalaiselvan, A; Jaccob, M; Venuvanalingam, P; Renganathan, R

    2008-05-29

    The fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by seven flavonoids namely flavone, flavanone, quercetin, rutin, genistein, diadzein and chrysin has been investigated in acetonitrile and dichloromethane solvents. The bimolecular quenching rate constants lie in the range of 0.09-5.75 x 10(9)M(-1)s(-1) and are explained in terms of structure of the flavonoids studied. The reactivity of flavonoids are in the order: quercetin>rutin>genistein>diadzein>chrysin>flavone>flavanone. The quenching rate constants (k(q)) increase with increase in the number of -OH groups. The endergonic thermodynamic values of DeltaG(et) reveal that electron transfer quenching mechanism can be ruled out. Bond dissociation enthalpy calculations reveal that the position of -OH is important. Further in vitro-antioxidant activities of flavonoids were evaluated with rat liver catalase by gel electrophoresis. The deuterium isotope effect thus observed in this work provides evidence for hydrogen abstraction involved in the quenching process of singlet excited DBO by flavonoids. The data suggest the involvement of direct hydrogen atom transfer (radical scavenging) in the fluorescence quenching of DBO. Bond dissociation enthalpy calculation performed at B3LYP/6-31G(p')//B3LYP/3-21G level are in excellent agreement with the above observations and further reveal that the number OH groups and position of them decide the quenching ability of the flavonoids.

  13. Theoretical study on the photolysis mechanism of 2,3-diazabicyclo[2.2.2]oct-2-ene.

    Science.gov (United States)

    Chen, Hui; Li, Shuhua

    2005-09-28

    A CASPT2/CASSCF study has been carried out to investigate the mechanism of the photolysis of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) under direct and triplet-sensitized irradiation. By exploring the detailed potential energy surfaces including intermediates, transition states, conical intersections, and singlet/triplet crossing points, for the first excited singlet (S(1)) and the low-lying triplet states (T(1), T(2), and T(3)), we provide satisfactory explanations of many experimental findings associated with the photophysical and photochemical processes of DBO. A key finding of this work is the existence of a significantly twisted S(1) minimum, which can satisfactorily explain the envelope of the broad emission band of DBO. It is demonstrated that the S(1) (n-pi*) intermediate can decay to the T(1) (n-pi*) state by undergoing intersystem crossing (rather inefficient) to the T(2) (pi-pi*) state followed by internal conversion to the T(1) state. The high fluorescence yield and the extraordinarily long lifetime of the singlet excited DBO are due to the presence of relatively high barriers, both for intersystem crossing and for C-N cleavage. The short lifetime of the triplet DBO is caused by fast radiationless decay to the ground state.

  14. Thiol-Ene Photo-Click Collagen-PEG Hydrogels: Impact of Water-Soluble Photoinitiators on Cell Viability, Gelation Kinetics and Rheological Properties

    Directory of Open Access Journals (Sweden)

    Róisín Holmes

    2017-06-01

    Full Text Available Thiol-ene photo-click hydrogels were prepared via step-growth polymerisation using thiol-functionalised type-I collagen and 8-arm poly(ethylene glycol norbornene-terminated (PEG-NB, as a potential injectable regenerative device. Type-I collagen was thiol-functionalised by a ring opening reaction with 2-iminothiolane (2IT, whereby up to 80 Abs.% functionalisation and 90 RPN% triple helical preservation were recorded via 2,4,6-Trinitrobenzenesulfonic acid (TNBS colorimetric assay and circular dichroism (CD. Type, i.e., either 2-Hydroxy-1-[4-(2-hydroxyethoxy phenyl]-2-methyl-1-propanone (I2959 or lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP, and concentration of photoinitiator were varied to ensure minimal photoinitiator-induced cytotoxicity and to enable thiol-ene network formation of collagen-PEG mixtures. The viability of G292 cells following 24 h culture in photoinitiator-supplemented media was largely affected by the photoinitiator concentration, with I2959-supplemented media observed to induce higher toxic response (0.1 → 0.5% (w/v I2959, cell survival: 62 → 2 Abs.% compared to LAP-supplemented media (cell survival: 86 → 8 Abs.%. In line with the in vitro study, selected photoinitiator concentrations were used to prepare thiol-ene photo-click hydrogels. Gelation kinetics proved to be largely affected by the specific photoinitiator, with LAP-containing thiol-ene mixtures leading to significantly reduced complete gelation time (τ: 187 s with respect to I2959-containing mixtures (τ: 1683 s. Other than the specific photoinitiator, the photoinitiator concentration was key to adjusting the hydrogel storage modulus (G’, whereby 15-fold G’ increase (232 → 3360 Pa was observed in samples prepared with 0.5% (w/v compared to 0.1% (w/v LAP. Further thiol-ene formulations with 0.5% (w/v LAP and varied content of PEG-NB were tested to prepare photo-click hydrogels with porous architecture, as well as tunable storage modulus (G

  15. Regulation of a putative corticosteroid, 17, 21-dihydroxypregn-4-ene, 3, 20-one, in sea lamprey, Petromyzon marinus.

    Science.gov (United States)

    Roberts, Brent W.; Didier, Wes; Satbir, Rai; Johnson, Nicholas S.; Libants, Scot V.; Sang-Seon, Yun; Close, David

    2013-01-01

    In higher vertebrates, in response to stress, the hypothalamus produces corticotropin-releasing hormone (CRH), which stimulates cells in the anterior pituitary to produce adrenocorticotropic hormone (ACTH), which in turn stimulates production of either cortisol (F) or corticosterone (B) by the adrenal tissues. In lampreys, however, neither of these steroids is present. Instead, it has been proposed that the stress steroid is actually 17,21-dihydroxypregn-4-ene-3,20-dione (11-deoxycortisol; S). However, there have been no studies yet to determine its mechanism of regulation or site of production. Here we demonstrate that (1) intraperitoneal injections of lamprey-CRH increase plasma S in a dose dependent manner, (2) intraperitoneal injections of four lamprey-specific ACTH peptides at 100 lg/kg, did not induce changes in plasma S concentrations in either males or females; (3) two lamprey-specific gonadotropin-releasing hormones (GnRH I and III) and arginine-vasotocin (AVT), all at single doses, stimulated S production as well as, or to an even greater extent than CRH; (4) sea lamprey mesonephric kidneys, in vitro, converted tritiated 17a-hydroxyprogesterone (17a-P) into a steroid that had the same chromatographic properties (on HPLC and TLC) as S; (5) kidney tissues released significantly more immunoassayable S into the incubation medium than gill, liver or gonad tissues. One interpretation of these results is that the corticosteroid production of the sea lamprey, one of the oldest extant vertebrates, is regulated through multiple pathways rather than the classical HPI-axis. However, the responsiveness of this steroid to the GnRH peptides means that a reproductive rather than a stress role for this steroid cannot yet be ruled out.

  16. Design and fabrication of uniquely shaped thiol-ene microfibers using a two-stage hydrodynamic focusing design.

    Science.gov (United States)

    Boyd, Darryl A; Shields, Adam R; Howell, Peter B; Ligler, Frances S

    2013-08-07

    Microfluidic systems have advantages that are just starting to be realized for materials fabrication. In addition to the more common use for fabrication of particles, hydrodynamic focusing has been used to fabricate continuous polymer fibers. We have previously described such a microfluidics system which has the ability to generate fibers with controlled cross-sectional shapes locked in place by in situ photopolymerization. The previous fiber fabrication studies produced relatively simple round or ribbon shapes, demonstrated the use of a variety of polymers, and described the interaction between sheath-core flow-rate ratios used to control the fiber diameter and the impact on possible shapes. These papers documented the fact that no matter what the intended shape, higher flow-rate ratios produced rounder fibers, even in the absence of interfacial tension between the core and sheath fluids. This work describes how to fabricate the next generation of fibers predesigned to have a much more complex geometry, as exemplified by the "double anchor" shape. Critical to production of the pre-specified fibers with complex features was independent control over both the shape and the size of the fabricated microfibers using a two-stage hydrodynamic focusing system. Design and optimization of the channels was performed using finite element simulations and confocal imaging to characterize each of the two stages theoretically and experimentally. The resulting device design was then used to generate thiol-ene fibers with a unique double anchor shape. Finally, proof-of-principle functional experiments demonstrated the ability of the fibers to transport fluids and to interlock laterally.

  17. Ära söö kiles saia ehk kas poliitilist kunsti on võimalik mõista? = Do not eat white bread in plastic, or is it possible to understand political art? / Ene-Liis Semper, Eero Epner

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2006-01-01

    Poliitillisest teatrist. NO99 lavastusest "Nafta" (lavastajad, autorid: Tiit Ojasoo, Ene-Liis Semper, kunstnik Ene-Liis Semper). Ettekanne Kaasaegse Kunsti Eesti Keskuse 4. ettekannete päeval "Kunstnike moraalsed valikud kultuurikonfliktides" Tallinna Kunstihoones 27.04.2006. Bibliograafia lk. 112

  18. Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes

    Energy Technology Data Exchange (ETDEWEB)

    Surendradoss, Jayakumar; Chang, Thomas K.H.; Abbott, Frank S., E-mail: frank.abbott@ubc.ca

    2012-11-01

    Valproic acid (VPA) undergoes cytochrome P450-mediated desaturation to form 4-ene-VPA, which subsequently yields (E)-2,4-diene-VPA by β-oxidation. Another biotransformation pathway involves β-oxidation of VPA to form (E)-2-ene-VPA, which also generates (E)-2,4-diene-VPA by cytochrome P450-mediated desaturation. Although the synthetic form of (E)-2,4-diene-VPA is more hepatotoxic than VPA as shown in various experimental models, there is no conclusive evidence to implicate the in situ generated (E)-2,4-diene-VPA in VPA hepatotoxicity. The present study investigated the effects of modulating the in situ formation of (E)-2,4-diene-VPA on markers of oxidative stress (formation of 2′,7′-dichlorofluorescein; DCF), steatosis (accumulation of BODIPY 558/568 C{sub 12}), necrosis (release of lactate dehydrogenase; LDH), and on cellular total glutathione (GSH) levels in sandwich-cultured rat hepatocytes treated with VPA or (E)-2-ene-VPA. Treatment with either of these chemicals alone increased each of the toxicity endpoints. In VPA-treated hepatocytes, (E)-2,4-diene-VPA was detected only at trace levels, even after phenobarbital (PB) pretreatment and there was no effect on the toxicity of VPA. Furthermore, pretreatment with a cytochrome P450 enzyme inhibitor, 1-aminobenzotriazole (1-ABT), did not influence the extent of VPA toxicity in both PB-pretreated and vehicle-pretreated hepatocytes. However, in (E)-2-ene-VPA-treated hepatocytes, PB pretreatment greatly enhanced the levels of (E)-2,4-diene-VPA and this was accompanied by a further enhancement of the effects of (E)-2-ene-VPA on DCF formation, BODIPY accumulation, LDH release, and GSH depletion. Pretreatment with 1-ABT reduced the concentrations of (E)-2,4-diene-VPA and the extent of (E)-2-ene-VPA toxicity; however, this occurred in PB-pretreated hepatocytes, but not in control hepatocytes. In conclusion, in situ generated (E)-2,4-diene-VPA is not responsible for the hepatocyte toxicity of VPA, whereas it

  19. Novel Anti-Biofouling Soft Contact Lens: l-Cysteine Conjugated Amphiphilic Conetworks via RAFT and Thiol-Ene Click Chemistry.

    Science.gov (United States)

    Zhang, Chengfeng; Liu, Ziyuan; Wang, Haiye; Feng, Xiaofeng; He, Chunju

    2017-07-01

    A unique l-cysteine conjugated antifouling amphiphilic conetwork (APCN) is synthesized through end-crosslinking of well-defined triblock copolymers poly(allyl methacrylate)-b-poly(ethylene glycol)-b-poly(allyl methacrylate) via a combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and thiol-ene "click" chemistry. The synthesized poly(ethylene glycol) macro-RAFT agent initiates the polymerization of allyl methacrylate in a controlled manner. The vinyl pendant groups of the precursor partially conjugate with l-cysteine and the rest fully crosslink with mercaptopropyl-containing siloxane via thiol-ene click chemistry under UV irradiation into APCNs, which show distinguished properties, that is, excellent biocompatibility, more than 39.6% water content, 101 barrers oxygen permeability, optimized mechanical properties, and more than 93% visible light transmittance. What's more, the resultant APCNs exhibit eminent resistance to protein adsorption, where the bovine serum albumin and lysozyme adsorption are decreased to 12 and 21 µg cm -2 , respectively. The outstanding properties of APCNs depend on the RAFT controlled method, which precisely designs the hydrophilic/hydrophobic segments and eventually greatly improves the crosslinking efficiency and homogeneity. Meantime, the l-cysteine monolayer can effectively reduce the surface hydrophobicity and prevent protein adsorption, which exhibits the viability for antifouling surface over and under ophthalmic devices, suggesting a promising soft contact lens. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Synthesis of Upconverting Hydrogel Nanocomposites Using Thiol-Ene Click Chemistry: Template for the Formation of Dendrimer-Like Gold Nanoparticle Assemblies.

    Science.gov (United States)

    Meesaragandla, Brahmaiah; Mahalingam, Venkataramanan

    2015-11-16

    The synthesis of upconverting hydrogel nanocomposites by base-catalyzed thiol-ene click reaction between 10-undecenoic acid capped Yb(3+)/Er(3+)-doped NaYF4 nanoparticles and pentaerythritol tetrakis(3-mercaptopropionate) (PETMP) as tetrathiol monomer is reported. This synthetic strategy for nanocomposite gels is quite different from works where usually the preformed gels are mixed with the nanoparticles. Developing nanocomposites by surface modification of capping ligands would allow tuning and controlling of the separation of the nanoparticles inside the gel network. The hydrogel nanocomposites prepared by thiol-ene click reaction show strong enhancement in luminescence intensity compared to 10-undecenoic acid-capped Yb(3+)/Er(3+)-doped NaYF4 nanoparticles through the upconversion process (under 980 nm laser excitation). The hydrogel nanocomposites display strong swelling characteristics in water resulting in porous structures. Interestingly, the resulting nanocomposite gels act as templates for the synthesis of dendrimer-like Au nanostructures when HAuCl4 is reduced in the presence of the nanocomposite gels. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Pyriculins A and B, two monosubstituted hex-4-ene-2,3-diols and other phytotoxic metabolites produced by Pyricularia grisea isolated from buffelgrass (Cenchrus ciliaris).

    Science.gov (United States)

    Masi, Marco; Meyer, Susan; Górecki, Marcin; Mandoli, Alessandro; Di Bari, Lorenzo; Pescitelli, Gennaro; Cimmino, Alessio; Cristofaro, Massimo; Clement, Suzette; Evidente, Antonio

    2017-11-01

    Pyricularia grisea has been identified as a foliar pathogen on buffelgrass (Cenchrus ciliaris) in North America and was studied as a potential source of phytotoxins for buffelgrass control. Two monosubstituted hex-4-ene-2,3-diols, named pyriculins A and B, were isolated from its culture filtrate organic extract together with (10S,11S)-(-)-epipyriculol, trans-3,4-dihydro-3,4,8-trihydroxy-1(2H)-napthalenone, and (4S)-(+)-isosclerone. Pyriculins A and B were characterized by spectroscopic (essentially nuclear magnetic resonance [NMR], High-resolution electrospray ionization mass spectrometry [HRESIMS]) and chemical methods such as (4E)-1-(4-hydroxy-1,3-dihydroisobenzofuran-1-yl)hex-4-ene-2,3-diols. The relative and absolute configuration of these compounds was determined by a combination of spectroscopic (NMR, electronic circular dichroism [ECD]) and computational tools. When bioassayed in a buffelgrass coleoptile and radicle elongation test, (10S,11S)-(-)-epipyriculol proved to be the most toxic compound. Seed germination was much reduced and slowed with respect to the control and radicles failed to elongate. All five compounds delayed germination, but only (10S,11S)-(-)-epipyriculol was able to prevent radicle development of buffelgrass seedlings. It had no effect on coleoptile elongation, while the other four compounds caused significantly increased coleoptile development relative to the control. © 2017 Wiley Periodicals, Inc.

  2. Grunge kodukujunduses / Ene Vool

    Index Scriptorium Estoniae

    Vool, Ene, 1948-

    2004-01-01

    Low-tech, campi ja grunge ehitus- ja sisustusstiilidest meil ja mujal - kommenteerivad Andro Kööp ja Ain Nurmela. Tutvustatakse ka Mari-Mira projekti Pariisis, mis kujutab endast nn. mutant-küla, putka- ja onnikultuuri koketeriid. Artikli lõpus kommenteerib kunstiteadlane Karin Paulus grungestiili muusikas, riietuses ja sisekujunduses.

  3. Taevo Gans / Ene Ammer

    Index Scriptorium Estoniae

    Ammer, Ene

    1998-01-01

    Sisearhitekt Taevo Gansist. Tudengipõlvest, selle aja projektidest, sõpruskonnast, tandemist Summatavet & Gans, Venemaa tellimustest, kaastöölistest. Üksinda Hommilkumaal vene tarbekunsti näitusega 1974. a. 1988. a. loodud perefirmast "GaDis" (omanikud Taevo, Helle Gans, Riia Oja), mis nõustab ka "Wermot" mööbli osas. "GaDise" sisekujundusprojektidest, millega Taevo ja Helle Gans tegelevad üheskoos

  4. Repliik / Ene Pajula

    Index Scriptorium Estoniae

    Pajula, Ene, 1950-

    2008-01-01

    Õpilaskodude foorumist ja õpilaskodudest, mis on loodud kodanikualgatuse korras ja nende inimeste tunnustamise vajadusest, tänu kellele meil on kakskümmend kaheksa õpilaskodu, kus elule tagasi võidetud saab nii mõnigi laps

  5. Whats 'App-ening'

    DEFF Research Database (Denmark)

    Ankersen, Dorit V; Weimers, Petra; Burisch, Johan

    2017-01-01

    in number. ehealth helps patients in coping with their disease by promoting self-management, which increases adherence to medical treatment and diets, and leads to an improved quality of life. For irritable bowel syndrome (IBS), there are multiple applications that provide dietary advice, for example, a low...

  6. Limitations of the Neurological Evolutional Exam (ENE as a motor assessment for first graders Limitações do Exame Neurológico Evolutivo (ENE como um instrumento de avaliação motora para crianças da primeira série

    Directory of Open Access Journals (Sweden)

    Priscila M. Caçola

    2010-10-01

    Full Text Available BACKGROUND: Many clinicians and researchers in Brazil consider the Neurological Developmental Exam (NDE, a valid and reliable assessment for Brazilian school-aged children. However, since its inception, several tests have emerged that, according to some researchers, provide more in-depth evaluation of motor ability and go beyond the detection of general motor status (soft neurological signs. OBJECTIVES: To highlight the limitations of the NDE as a motor skill assessment for first graders. METHODS: Thirty-five children were compared on seven selected items of the NDE, seven of the Bruininks-Oseretsky Test (BOT, and seven of the Visual-Motor Integration test (VMI. Participants received a "pass" or "fail" score for each item, as prescribed by the respective test manual. RESULTS: Chi-square and ANOVA results indicated that the vast majority of children (74% passed the NDE items, whereas values for the other tests were 29% (BOT and 20% (VMI. Analysis of specific categories (e.g. visual, fine, and gross motor coordination revealed a similar outcome. CONCLUSIONS: Our data suggest that while the NDE may be a valid and reliable test for the detection of general motor status, its use as a diagnostic/remedial tool for identifying motor ability is questionable. One of our recommendations is the consideration of a revised NDE in light of the current needs of clinicians and researchers.CONTEXTUALIZAÇÃO: Muitos clínicos e pesquisadores brasileiros consideram o Exame Neurológico Evolutivo (ENE, um instrumento válido e confiável para crianças brasileiras em idade escolar. Entretanto, desde a sua criação, surgiram outros testes para uma avaliação mais profunda de habilidade motora, os quais vão além de detectar status motor geral em forma de sinais neurológicos leves. OBJETIVOS: Demonstrar os pontos fracos do ENE como teste de avaliação de habilidade motora para crianças de primeira série. MÉTODOS: Trinta e cinco crianças realizaram 7 itens

  7. Reaalsust taltsutades / Jean-Louis Poitevin ; tõlk. Mailis Seero

    Index Scriptorium Estoniae

    Poitevin, Jean-Louis

    2008-01-01

    Läti, leedu ja eesti kunstnike ühisnäitus Pariisi Cite Internationale des Arts'is kuni 26. X. Kuraatorid: Aili Vahtrapuu, Liena Bondare, Birute Pankunaite. Miks Mitrevicsi, Inta Brunina, Laura Garbshtiene, Reiu Tüüri, Anu Kalmu, Peeter Alliku, Urmas Viigi, Anu Põdra, Jüri Ojaveri, Jaanus Samma, Ene-Liis Semperi, Mari-Liis Tammi, Angelika Schneideri ja Virge Jõekalda töödest

  8. The photochemical reaction of 1,1-dicyano-3-phenylbut-1-ene. Simultaneous occurrence of p-methane and di-p-methane rearrangements

    Directory of Open Access Journals (Sweden)

    Silva Francisco A. da

    1999-01-01

    Full Text Available The direct photolysis of 1,1-dicyano-3-phenylbut-1-ene (3-MDCN was investigated at room temperature in solvents of different polarities (hexane, dichloromethane and acetonitrile. Cyclopropanes arising from both the di-pi-methane and pi-methane (1,2-H migration processes were obtained as photoproducts. The structures of the products were elucidated by ¹H-NMR, GC/MS, IR and chromatography. Relative quantum yield determination and GC analysis of sequential irradiations gave evidence that: i no secondary reactions occur, even at high conversions; ii the di-pi-methane rearrangement is significantly more affected by the solvent variation than the pi-methane reaction. Photosensitization with acetophenone or acetone did not yield any observable products. The existence of the simultaneous mechanisms and the observed effects were considered as evidence of a possible differentiation between localized and delocalized excitation on the excited state surface.

  9. Ambiguity tolerance and the concept of "Innere führung" / Angelika Dörfler-Dierken

    Index Scriptorium Estoniae

    Dörfler-Dierken, Angelika

    2013-01-01

    Juhtimisfilosoofia ja sõjalise juhtimise põhimõtted sõjaväes Saksamaa näite põhjal, ohtude õige hindamise tähtsus ja sellele vastava tegevusviisi valimine sõduritel ja nende oskuste arendamine läbi laiapõhjalise väljaõppe

  10. Enantioselective synthesis of possible diastereomers of heptadeca-1-ene-4,6-diyne-3,8,9,10-tetrol; putative structure of a conjugated diyne natural product isolated from Hydrocotyle leucocephala.

    Science.gov (United States)

    Prasad, Kavirayani R; Swain, Bandita

    2011-04-01

    Enantioselective synthesis of possible diastereomers of heptadeca-1-ene-4,6-diyne-3,8,9,10-tetrol, a structure proposed for the natural product isolated from Hydrocotyle leucocephala is accomplished. The reported spectral data of the natural product did not match those of any of the isomers that were synthesized and established that the structure proposed for the natural product is not correct and requires revision.

  11. IN0523 (Urs-12-ene-3α,24β-diol) a plant based derivative of boswellic acid protect Cisplatin induced urogenital toxicity

    International Nuclear Information System (INIS)

    Singh, Amarinder; Arvinda, S; Singh, Surjeet; Suri, Jyotsna; Koul, Surinder; Mondhe, Dilip M.; Singh, Gurdarshan; Vishwakarma, Ram

    2017-01-01

    The limiting factor for the use of Cisplatin in the treatment of different type of cancers is its toxicity and more specifically urogenital toxicity. Oxidative stress is a well-known phenomenon associated with Cisplatin toxicity. However, in Cisplatin treated group, abnormal animal behavior, decreased body weight, cellular and sub-cellular changes in the kidney and sperm abnormality were observed. Our investigation revealed that Cisplatin when administered in combination with a natural product derivative (Urs-12-ene-3α,24β-diol, labeled as IN0523) resulted in significant restoration of body weight and protection against the pathological alteration caused by Cisplatin to kidney and testis. Sperm count and motility were significantly restored near to normal. Cisplatin caused depletion of defense system i.e. glutathione peroxidase, catalase and superoxide dismutase, which were restored close to normal by treatment of IN0523. Reduction in excessive lipid peroxidation induced by Cisplatin was also found by treatment with IN0523. The result suggests that IN0523 is a potential candidate for ameliorating Cisplatin induced toxicity in the kidney and testes at a dose of 100 mg/kg p.o. via inhibiting the oxidative stress/redox status imbalance and may be improving the efflux mechanism. - Highlights: • Synthesis of a novel boswellic acid derivative (IN0523) • Counter oxidative stress induced due to Cisplatin • Protect against urogenital toxicity induced by Cisplatin

  12. Occurrence of (Z)-3,4-Dideoxyglucoson-3-ene in Different Types of Beer and Malt Beer as a Result of 3-Deoxyhexosone Interconversion.

    Science.gov (United States)

    Hellwig, Michael; Nobis, Arndt; Witte, Sophia; Henle, Thomas

    2016-04-06

    In beer, 3-deoxyglucosone (3-DG) and 3-deoxygalactosone (3-DGal) are important sugar degradation products, but little is known about the relevance of the interconversion reaction between these compounds in different types of beer. In the present study, 3-DG was quantitated at concentrations of 12.9-52.7 mg/L and 3-DGal at concentrations of 6.0-26.4 mg/L in different types of beer (pilsner, wheat, bock, dark, and alcohol-free beers). The concentrations in malt beer tended to be higher. Largely overlapping concentration ranges precluded a classification of beers by their 3-deoxyglycosone contents. 3,4-Dideoxyglucoson-3-ene (3,4-DGE) was identified as an important intermediate and quantitated in beer and malt beer for the first time. The E and Z isomers of the corresponding quinoxaline were synthesized by a new synthetic approach and isolated by semipreparative HPLC. An assay was developed for quantitation of (E)- and (Z)-3,4-DGE by HPLC-MS/MS, and the Z isomer was determined at concentrations of 0.3-1.7 mg/L in beer and 0.5-4.8 mg/L in malt beer samples. The E isomer was shown to be of little importance. Concentrations of 5-hydroxymethylfurfural (HMF) were twice as high as those of (Z)-3,4-DGE in beer samples (0.4-3.7 mg/L) but much higher in malt beer samples (1.6-336 mg/L).

  13. The synthesis of weak acidic type hybrid monolith via thiol-ene click chemistry and its application in hydrophilic interaction chromatography.

    Science.gov (United States)

    Zeng, Jiao; Liu, Shengquan; Wang, Menglin; Yao, Shouzhuo; Chen, Yingzhuang

    2017-05-01

    In this work, a porous structure and good permeability monolithic column was polymerized in UV transparent fused-silica capillaries via photo-initiated thiol-ene click polymerization of 2,4,6,8-tetravinyl-2,4,6,8-tetramethylcyclotetrasiloxane (TMTVS), pentaerythritol tetra(3-mercaptopropionate)(PETMP), itaconic acid, respectively, in the presence of porogenic solvents (tetrahydrofuranand methanol) and an initiator (2,2-dimethoxy-2-phenylacetophenone) (DMPA) within 30 min. The physical properties of this monolith were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and nitrogen adsorption/desorption measurements. For an overall evaluation of the monolith in chromatographic application, separations of polycyclic aromatic hydrocarbons (PAHs), phenols, amides and bases were carried out. The column efficiency of this monolith could be as high as 112 560 N/m. It also possesses a potential application in fabrication of monoliths with high efficiency for c-LC. In addition, the resulting monolithic column demonstrated the potential use in analysis of environment waters. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Thiol-ene immobilisation of carbohydrates onto glass slides as a simple alternative to gold-thiol monolayers, amines or lipid binding.

    Science.gov (United States)

    Biggs, Caroline I; Edmondson, Steve; Gibson, Matthew I

    2015-01-01

    Carbohydrate arrays are a vital tool in studying infection, probing the mechanisms of bacterial, viral and toxin adhesion and the development of new treatments, by mimicking the structure of the glycocalyx. Current methods rely on the formation of monolayers of carbohydrates that have been chemically modified with a linker to enable interaction with a functionalised surface. This includes amines, biotin, lipids or thiols. Thiol-addition to gold to form self-assembled monolayers is perhaps the simplest method for immobilisation as thiolated glycans are readily accessible from reducing carbohydrates in a single step, but are limited to gold surfaces. Here we have developed a quick and versatile methodology which enables the use of thiolated carbohydrates to be immobilised as monolayers directly onto acrylate-functional glass slides via a 'thiol-ene'/Michael-type reaction. By combining the ease of thiol chemistry with glass slides, which are compatible with microarray scanners this offers a cost effective, but also useful method to assemble arrays.

  15. Poly(allyl methacrylate) functionalized hydroxyapatite nanocrystals via the combination of surface-initiated RAFT polymerization and thiol-ene protocol: a potential anticancer drug nanocarrier.

    Science.gov (United States)

    Bach, Long Giang; Islam, Md Rafiqul; Vo, Thanh-Sang; Kim, Se-Kwon; Lim, Kwon Taek

    2013-03-15

    Hydroxyapatite nanocrystals (HAP NCs) were encapsulated by poly(allyl methacrylate) (PolyAMA) employing controlled surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization of allyl methacrylate to afford HAP-PolyAMA nanohybrids. The subsequent thiol-ene coupling of nanohybrids with 2-mercaptosuccinic acid resulted HAP-Poly(AMA-COOH) possessing multicarboxyl group. The formation of the nanohybrids was confirmed by FT-IR and EDS analyses. The TGA and FE-SEM investigation were further suggested the grafting of PolyAMA onto HAP NCs. The utility of the HAP-PolyAMA nanohybrid as drug carrier was also explored. The pendant carboxyl groups on the external layers of nanohybrids were conjugated with anticancer drug cisplatin to afford HAP-Poly(AMA-COOH)/Pt complex. The formation of the complex was confirmed by FT-IR, XPS, and FE-SEM. In vitro evaluation of the synthesized complex as nanomedicine revealed its potential chemotherapeutic efficacy against cancer cell lines. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. Synthesis of Pyridine and Spiropyridine Derivatives Derived from 2-aminoprop- 1-ene-1,1,3-tricarbonitrile Together with their c-Met Kinase and Antiproliferative Evaluations.

    Science.gov (United States)

    Mohareb, Rafat M; Abouzied, Amr S; Abbas, Nermeen S

    2018-02-07

    Among a wide range of pyridines, 3-cyanopyridines acquired a special attention due to their wide range of pharmacological activities especially the therapeutic activities. Many pharmacological drugs containing the pyridine nucleus were known in the market. The aim of this work was to synthesize target molecules not only possess anti-tumor activities but also kinase inhibitors. To achieve this goal, our strategy was to synthesize a series of 3-cyanopyridine derivatives using 2-aminoprop-1-ene-1,1,3-tricarbonitrile (1) as the key starting material for many heterocyclization reactions. Muticoponent reactions were adopted using compound 1 to get different pyridine derivatives that were capable for different heterocyclization reactions. Antiproliferative evaluations and c-Met kinase, Pim-1 kinse inhibitions were perform where some compounds gave high activities. Compounds that showed high antiprolifeative activity were tested gor c-Met-independent and the results showed that compounds 5c, 5e, 5f, 7c, 7f and 16d were more active than foretinib. The Pim-1 kinase inhibition activity of some selected compounds showed that compounds 5e and 16c were high potent to inhibit Pim-1 activity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  17. Properties of solid electrolyte interphase formed by prop-1-ene-1,3-sultone on graphite anode of Li-ion batteries

    International Nuclear Information System (INIS)

    Li, Bin; Xu, Mengqing; Li, Benzhen; Liu, Yanlin; Yang, Liang; Li, Weishan; Hu, Shejun

    2013-01-01

    Highlights: • SEI formed by PES on NG was characterized with charge/discharge test, SEM, FTIR, and XPS. • NG in PC-based electrolyte can be well protected using PES. • Sulfur-containing species is the main component of the SEI formed by PES. • Preferable reduction of PES results in the formation of protective SEI on NG. -- Abstract: The physical and chemical properties of the solid electrolyte interphase (SEI) formed by prop-1-ene-1,3-sultone (PES) on graphite anode in propylene carbonate (PC) based electrolyte for lithium ion battery were investigated by charge–discharge test, scanning electron spectroscopy with energy dispersive X-ray spectroscopy (SEM–EDS), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). It is found that the charge–discharge performance of the cell LiCoO 2 /natural graphite (NG) using PC-based electrolyte containing 3 wt% PES is superior to that containing 6 wt% propane sultone (PS), an SEI formation additive that has the similar molecular structure to PES but is reduced not as easily as PES. The results from SEM–EDS, FTIR and XPS show that the structure of graphite has been protected and some S-containing species are proven to be components of the SEI, suggesting that the preferable reduction of PES plays an important role in the formation of a protective SEI on NG

  18. IN0523 (Urs-12-ene-3α,24β-diol) a plant based derivative of boswellic acid protect Cisplatin induced urogenital toxicity

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Amarinder [Academy of Scientific & Innovative Research (AcSIR), New Delhi (India); PK-PD-Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J& K (India); Arvinda, S [Deptt. of Pathology, Govt. Medical College, Jammu 180001, J& K (India); Singh, Surjeet [PK-PD-Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J& K (India); Suri, Jyotsna [Deptt. of Pathology, Govt. Medical College, Jammu 180001, J& K (India); Koul, Surinder [Bio-Organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J& K (India); Mondhe, Dilip M. [Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J& K (India); Singh, Gurdarshan, E-mail: singh_gd@iiim.ac.in [PK-PD-Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J& K (India); Vishwakarma, Ram [Bio-Organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J& K (India)

    2017-03-01

    The limiting factor for the use of Cisplatin in the treatment of different type of cancers is its toxicity and more specifically urogenital toxicity. Oxidative stress is a well-known phenomenon associated with Cisplatin toxicity. However, in Cisplatin treated group, abnormal animal behavior, decreased body weight, cellular and sub-cellular changes in the kidney and sperm abnormality were observed. Our investigation revealed that Cisplatin when administered in combination with a natural product derivative (Urs-12-ene-3α,24β-diol, labeled as IN0523) resulted in significant restoration of body weight and protection against the pathological alteration caused by Cisplatin to kidney and testis. Sperm count and motility were significantly restored near to normal. Cisplatin caused depletion of defense system i.e. glutathione peroxidase, catalase and superoxide dismutase, which were restored close to normal by treatment of IN0523. Reduction in excessive lipid peroxidation induced by Cisplatin was also found by treatment with IN0523. The result suggests that IN0523 is a potential candidate for ameliorating Cisplatin induced toxicity in the kidney and testes at a dose of 100 mg/kg p.o. via inhibiting the oxidative stress/redox status imbalance and may be improving the efflux mechanism. - Highlights: • Synthesis of a novel boswellic acid derivative (IN0523) • Counter oxidative stress induced due to Cisplatin • Protect against urogenital toxicity induced by Cisplatin.

  19. IN0523 (Urs-12-ene-3α,24β-diol) a plant based derivative of boswellic acid protect Cisplatin induced urogenital toxicity.

    Science.gov (United States)

    Singh, Amarinder; Arvinda, S; Singh, Surjeet; Suri, Jyotsna; Koul, Surinder; Mondhe, Dilip M; Singh, Gurdarshan; Vishwakarma, Ram

    2017-03-01

    The limiting factor for the use of Cisplatin in the treatment of different type of cancers is its toxicity and more specifically urogenital toxicity. Oxidative stress is a well-known phenomenon associated with Cisplatin toxicity. However, in Cisplatin treated group, abnormal animal behavior, decreased body weight, cellular and sub-cellular changes in the kidney and sperm abnormality were observed. Our investigation revealed that Cisplatin when administered in combination with a natural product derivative (Urs-12-ene-3α,24β-diol, labeled as IN0523) resulted in significant restoration of body weight and protection against the pathological alteration caused by Cisplatin to kidney and testis. Sperm count and motility were significantly restored near to normal. Cisplatin caused depletion of defense system i.e. glutathione peroxidase, catalase and superoxide dismutase, which were restored close to normal by treatment of IN0523. Reduction in excessive lipid peroxidation induced by Cisplatin was also found by treatment with IN0523. The result suggests that IN0523 is a potential candidate for ameliorating Cisplatin induced toxicity in the kidney and testes at a dose of 100mg/kg p.o. via inhibiting the oxidative stress/redox status imbalance and may be improving the efflux mechanism. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Critical Parameters and Critical-Region (p,ρ ,T) Data of trans-1,1,1,3-Tetrafluorobut-2-ene [HFO-1354mzy(E)

    Science.gov (United States)

    Kimura, Takeru; Kayukawa, Yohei; Miyamoto, Hiroyuki; Saito, Kiyoshi

    2017-08-01

    This study presents the experimental measurement of the pρ T properties and critical parameters of a low GWP type refrigerant, trans-1,1,1,3-Tetrafluorobut-2-ene (HFO-1354mzy(E)). The sample purity of the substance was 99 area %. p ρ T property measurements and visual observations of the meniscus of HFO-1354mzy(E) were carried out using a metal-bellows volumometer with an optical cell. The critical temperature was determined by observation of the critical opalescence. The critical pressure and critical density were determined as the inflection point of the isothermal p ρ T property data at the critical temperature. For more precise clarification of the thermodynamic surface in the vicinity of the critical point, additional p ρ T property measurements were carried out on three isotherms in the supercritical region. The expanded uncertainties (k = 2) in the temperature, pressure, and density measurements were estimated to be less than 3 mK, 1.2 kPa, and 0.32 \\hbox {kg} \\cdot \\hbox {m}^{-3}, respectively. The expanded uncertainties of the critical parameters were estimated to be less than 13 mK, 1.4 kPa, and 2.3 \\hbox {kg} \\cdot \\hbox {m}^{-3}, respectively. These values are the first reported for HFO-1354mzy(E) and are necessary for the development of its equation of state in the near future.

  1. Reaction of singlet-excited 2,3-diazabicyclo[2.2.2]oct-2-ene and tert-butoxyl radicals with aryl-substituted benzofuranones.

    Science.gov (United States)

    Lundgren, Cecilia Vannesjö; Koner, Apurba L; Tinkl, Michael; Pischel, Uwe; Nau, Werner M

    2006-03-03

    5,7-Di-tert-butyl-3-aryl-3H-benzofuran-2-ones are lactones with potential antioxidant activity, owing to their abstractable benzylic C-H hydrogens. The fluorescence quenching of the azoalkane 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO), an established probe for the hydrogen-donor propensity of chain-breaking antioxidants, was investigated for 16 aryl-substituted benzofuranone derivatives [m,m-(CF3)2, p-CN, m-CN, p-CF3, p-COOCH3, m-CF3, p-Cl, p-F, H, m-CH3, p-CH3, m,p-(CH3)2, p-OCH3, o-CH3, o-CF3, o,m-(CH3)2]. Analysis of the rate data in terms of a linear free energy relationship yielded a reaction constant of rho = +0.35. This implies that n,pi*-excited DBO acts as nucleophilic species. In contrast, hydrogen abstraction of tert-butoxyl radicals from the benzofuranones was accelerated by electron-donating substituents (rho = -0.23), in conformity with the electrophilic character of oxygen-centered alkoxyl radicals. Possible implications for the optimization of the hydrogen-donor propensity of antioxidants through structural variation are discussed.

  2. Investigation of the fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by certain substituted uracils

    Energy Technology Data Exchange (ETDEWEB)

    Anbazhagan, V. [School of Chemistry, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu (India); Renganathan, R. [School of Chemistry, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu (India)], E-mail: rrengas@yahoo.com

    2009-04-15

    The fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by a series of uracils has been studied in water and acetonitrile solvents using steady-state and time-resolved fluorescence techniques. The steady-state fluorescence quenching technique has been performed in three different pHs (i.e. 4, 8 and 12). The bimolecular quenching rate constant (k{sub q}) increases with increase in pH of uracils. In acidic pH, a pure hydrogen atom abstraction is proposed as the quenching mechanism. This is supported by a pronounced solvent deuterium isotope effect. Electron transfer from the anionic form of uracil to the excited state of DBO is proposed as a mechanism for quenching in basic pH on the basis of highly exergonic thermodynamics obtained from the Rehm-Weller equation. The variation of k{sub q} is explained on the basis of the electronic effect of substitution in uracils as well.

  3. Investigation of the fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by certain substituted uracils

    International Nuclear Information System (INIS)

    Anbazhagan, V.; Renganathan, R.

    2009-01-01

    The fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) by a series of uracils has been studied in water and acetonitrile solvents using steady-state and time-resolved fluorescence techniques. The steady-state fluorescence quenching technique has been performed in three different pHs (i.e. 4, 8 and 12). The bimolecular quenching rate constant (k q ) increases with increase in pH of uracils. In acidic pH, a pure hydrogen atom abstraction is proposed as the quenching mechanism. This is supported by a pronounced solvent deuterium isotope effect. Electron transfer from the anionic form of uracil to the excited state of DBO is proposed as a mechanism for quenching in basic pH on the basis of highly exergonic thermodynamics obtained from the Rehm-Weller equation. The variation of k q is explained on the basis of the electronic effect of substitution in uracils as well

  4. Crystal and Molecular Structure Studies of Ethyl 4-(4-Hydroxyphenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate and Ethyl 4-(3-Bromophenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate

    Directory of Open Access Journals (Sweden)

    Badiadka Narayana

    2012-08-01

    Full Text Available The crystal and molecular structures of the title compounds, ethyl 4-(4-hydroxyphenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate (I and ethyl 4-(3-bromophenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate (II, are reported and confirmed by single crystal X-ray diffraction data. Compound (I, C26H24O5, crystallizes from a methanol solution in the monoclinic C2/c space group with eight molecules in the unit cell. The unit cell parameters are: a = 25.4114(5 Å, b = 8.47440(10 Å, c = 20.6921(4 Å, β = 108.328(2° and V = 4229.92(13 Å3. Disorder is observed throughout the entire molecule with an occupancy ratio 0.690(2:0.310(2. Compound (II, C26H23O4Br, crystallizes from an ethyl acetate solution in the monoclinic P21/c spacegroup with four molecules in the unit cell. The unit cell parameters are a = 17.8991(9 Å, b = 11.4369(6 Å, c = 10.8507(5 Å, β = 92.428(4° and V = 2219.25(19 Å3. Disorder is observed in the cyclohexenone ring and the carboxylate group with an occupancy ratio 0.830(6:0.170(6. Weak O–H...O (I or C–H...O (II intermolecular interactions are observed which influence crystal packing stability. These chalcone derivative types of molecules are important in their ability to act as activated unsaturated systems in conjugated addition reactions of carbanions in the presence of basic catalysts which exhibit a multitude of biological activities.

  5. C60 and Sc3N@C80(TMB-PPO derivatives as constituents of singlet oxygen generating, thiol-ene polymer nanocomposites

    Directory of Open Access Journals (Sweden)

    Ashli R. Toles

    2016-07-01

    Full Text Available Numerous functionalization methods have been employed to increase the solubility, and therefore, the processability of fullerenes in composite structures, and of these radical addition reactions continue to be an important methodology. C60 and Sc3N@C80 derivatives were prepared via radical addition of the photodecomposition products from the commercial photoinitiator TMB-PPO, yielding C60(TMB-PPO5 and Sc3N@C80(TMB-PPO3 as preferred soluble derivatives obtained in high yields. Characterization of the mixture of isomers using standard techniques suggests an overall 1PPO:6TMB ratio of addends, reflecting the increased reactivity of the carbon radical. Although, a higher percentage of PPO is observed in the Sc3N@C80(TMB-PPO3 population, perhaps due to reverse electronic requirements of the substrate. Visually dispersed thiol-ene nanocomposites with low extractables were prepared using two monomer compositions (PETMP:TTT and TMPMP:TMPDE with increasing fullerene derivative loading to probe network structure-property relationships. Thermal stability of the derivatives and the resulting networks decreased with increased functionality and at high fullerene loadings, respectively. TMPMP:TMPDE composite networks show well-dispersed derivatives via TEM imaging, and increasing Tg’s with fullerene loading, as expected for the incorporation of a more rigid network component. PETMP:TTT composites show phase separation in TEM, which is supported by the observed Tg’s. Singlet oxygen generation of the derivatives decreases with increased functionality; however, this is compensated for by the tremendous increase in solubility in organic solvents and miscibility with monomers. Most importantly, singlet oxygen generation from the composites increased with fullerene derivative loading, with good photostability of the networks.

  6. Spectral behavior and photophysical parameters of (2Z)-3-[4-(dimethylamino) phenyl]-2-(4-fluorophenyl) prop-2-ene-nitrile (DPF) in different media

    Energy Technology Data Exchange (ETDEWEB)

    Pannipara, Mehboobali [Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589 (Saudi Arabia); Asiri, Abdullah M. [Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589 (Saudi Arabia); Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, P.O. Box 80203 (Saudi Arabia); Alamry, Khalid A. [Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589 (Saudi Arabia); Salem, Ibrahim A. [Department of Chemistry, Faculty of Science, Tanta University, 31527 Tanta (Egypt); El-Daly, Samy A., E-mail: samyeldaly@yahoo.com [Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589 (Saudi Arabia); Department of Chemistry, Faculty of Science, Tanta University, 31527 Tanta (Egypt)

    2015-01-15

    A new fluorophore, (2Z)-3-[4-(dimethylamino) phenyl]-2-(4-fluorophenyl) prop-2-ene-nitrile (DPF), was synthesized by knoevenagel condensation of 4-(dimethylamino) benzaldehyde and 4-fluorobenzyl cyanide in ethanol using NaOH as base. The electronic absorption and emission characteristic of DPF were studied in different solvents. The X-ray crystallographic structure of DPF was also investigated. DPF exhibits a red-shift in its emission spectrum as solvent polarity increases, indicating a large change in the dipole moment of dye molecule upon excitation due to intramolecular charge transfer in excited DPF{sup ⁎}. The fluorescence quantum yield depends strongly on the properties of the solvents, which was attributed to positive and negative solvatokinetic effects. A crystalline solid of DPF gives a strong yellow emission at about 532 nm; these phenomena are important for the application of DPF dye in organic photoemitting diode. The photochemical quantum yield of cis–trans isomerization of DPF was also determined in different solvents. The DPF dye displays solubilization in both cationic (CTAB) and anionic (SDS) micelle and may be used as a probe to determine the critical micelle concentration (CMC) of SDS and CTAB. - Highlights: • Organic pi conjugated molecule with a donor acceptor group was studied. • Crystalline solid of the molecule shows strong and intense yellow emission. • The dye displays solubilization in cationic micelle with abrupt change in emission intensity at CMC. • This work gives an insight into the application of organic luminescent material in various fields.

  7. Design of peptide substrates for nanosecond time-resolved fluorescence assays of proteases: 2,3-diazabicyclo[2.2.2]oct-2-ene as a noninvasive fluorophore.

    Science.gov (United States)

    Hennig, Andreas; Florea, Mara; Roth, Doris; Enderle, Thilo; Nau, Werner M

    2007-01-15

    Fluorescence protease assays were investigated with peptide substrates containing a 2,3-diazabicyclo[2.2.2]oct-2-ene-labeled asparagine (Dbo) as a fluorescent amino acid. The special characteristic of the fluorophore Dbo is its exceedingly long fluorescence lifetime (ca. 300 ns in water under air), which allows the use of nanosecond time-resolved fluorescence (Nano-TRF) detection to efficiently suppress shorter-lived background emission. In addition, the natural amino acids tryptophan and tyrosine can be employed as intramolecular fluorescence quenchers, which facilitates substrate design. Fourteen synthetic peptide substrates (composed of 2-19 amino acids) and five enzymes (trypsin, pepsin, carboxypeptidase A, leucine aminopeptidase, and chymotrypsin) were investigated and, in all 28 examined combinations, enzymatic activity was detected by monitoring the increase in steady state fluorescence with time and determining the reaction rates as kcat/Km values, which ranged from 0.2 to 80x10(6) M-1 min-1. The results suggest an excellent compatibility of the very small and hydrophilic fluorescent probe Dbo with solid-phase peptide synthesis and the investigated proteases. For all 14 peptides the fluorescence lifetimes before and after enzymatic cleavage were measured and Nano-TRF measurements were performed in 384-well microplates. The fluorescence lifetimes of the different peptides provide the basis for the rational design of Dbo-based fluorescent substrates for protease assays. Measurements in Nano-TRF mode revealed, in addition to efficient suppression of background fluorescence, an increased differentiation between cleaved and uncleaved substrate. The Dbo-based assays can be adapted for high-throughput screening.

  8. Refractive index effects on the oscillator strength and radiative decay rate of 2,3-diazabicyclo[2.2.2]oct-2-ene.

    Science.gov (United States)

    Mohanty, Jyotirmayee; Nau, Werner M

    2004-01-01

    The photophysical properties of 2,3-diazabicyclo[2.2.2]oct-2-ene (DBO) were determined in 15 solvents, two supramolecular hosts (cucurbit[7]uril and beta-cyclodextrin) as well as in the gas phase. The oscillator strength and radiative decay rate of DBO as a function of refractive index i.e. polarizability have been analyzed. The oscillator strength increases by a factor of 10 upon going from the gas phase to the most polarizable carbon disulfide, while the corresponding radiative decay rates increase by a factor of 40. There is a good empirical correlation between the oscillator strength of the weakly allowed n,pi* transition of DBO and the reciprocal bulk polarizability, which can be employed to assess the polarizability of unknown microheterogeneous environments. A satisfactory correlation between the radiative decay rate and the square of the refractive index is also found, as previously documented for chromophores with allowed transitions. However, the correlation improves significantly when the oscillator strength is included in the correlation, which demonstrates the importance of this factor in the Strickler-Berg equation for chromophores with forbidden or weakly allowed transitions, for which the oscillator strength may be strongly solvent dependent. The radiative decay rate of DBO in two supramolecular assemblies has been determined, confirming the very low polarizability inside the cucurbituril cavity, in between perfluorohexane and the gas phase. The fluorescence quantum yield of DBO in the gas phase has been remeasured (5.1 +/- 0.5%) and was found to fall one full order of magnitude below a previously reported value.

  9. 1,4a-Dimethyl-6-methyl-ene-5-(5,5,6,6-tetra-cyano-2-methyl-cyclo-hex-2-enylmeth-yl)deca-hydro-naphthalene-1-carboxylic acid: a trans-communic acid derivative.

    Science.gov (United States)

    Rejouani, Nezha; Auhmani, Aziz; Ait Itto, My Youssef; Benharref, Ahmed; Daran, Jean-Claude

    2008-01-18

    In the search for cancer chemopreventive agents, we have studied the Diels-Alder reaction of trans-communic acid with tetra-cyano-ethyl-ene in the presence of SiO(2) as catalyst. The title cycloadduct, C(26)H(30)N(4)O(2), was obtained in 75% yield. The mol-ecules are arranged in pairs through O-H⋯O hydrogen bonds, forming an R(2) (2)(8) ring motif. Both the fused cyclohexyl rings adopt a chair conformation, whereas the nonfused ring adopts a half-chair conformation.

  10. Estimación del impacto económico de los museos a través de las nuevas tecnologías de la información: el caso del museo Ene.Térmica

    Directory of Open Access Journals (Sweden)

    Vicente COLL-SERRANO

    Full Text Available Cada vez es más necesario poner de relieve el potencial de la cultura como motor del desarrollo económico y su capacidad para generar ingresos y crear empleo. Por este motivo, en este trabajo se evalúa el impacto económico del museo Ene.Térmica sobre el territorio en el que se ubica, Ponferrada (Comunidad de Castilla y León, España. Para lograr este objetivo, la estimación de los distintos tipos de efectos necesarios para determinar el impacto de las actividades económicas vinculas a la existencia de Ene.Térmica se realiza, en base a la metodología de las Tablas Input-Output, mediante la herramienta Impactrimonio, una aplicación implementada sobre una plataforma web. Los resultados obtenidos indican que entre las actividades del museo y los flujos de demanda desplegados por el efecto arrastre de los visitantes se generó, entre los años 2011 y 2012, un incremento de la producción de más de 15 millones de euros, un incremento de las rentas de la población de casi 10 millones de euros y un aumento de la ocupación de 327 empleos.

  11. Kadriorust leiate pargiraamatukogu / Ene Tamsalu

    Index Scriptorium Estoniae

    Tamsalu, Ene

    2009-01-01

    2006. aastal avati Kadrioru Pargi raamatukogu, mille kogu aluseks on soome maastikuarhitektuuri professori Tuula Maria Merivuori pärandatud erialaraamatukogu, kus leiab kirjandust maastiku-, pargi- ja aiaarhitektuurist, linna- ja regionaalplaneerimisest, botaanikast ja aiandusest

  12. LEADER-tegevusest / Ene Sarapuu

    Index Scriptorium Estoniae

    Sarapuu, Ene

    2009-01-01

    Läänemaa LEADER-tegevusgrupi eesmärk on maakonna kui terviku ühtne areng, et kogu Läänemaa oleks vajalike teenustega kaetud ning ettevõtjad julgeks ning suudaks uute teenuste ja toodetega turule tulla

  13. Messiuudised : Maison & Objet / Ene Jakobi

    Index Scriptorium Estoniae

    Jakobi, Ene

    2008-01-01

    Uusi trende kõige suuremalt disainimessilt Maison & Objet Prantsusmaal - Jean-Charles de Castelbajaci joonistatud toolid, Jean-Christophe Bernardi pleksiklaasist tool ja laud, Joseph Licciardi ja Paul Coheni-Philipp Veenendaali etanoolil põlevad kaminad, Philippe Lebru kellad, Vincenzo Antonuccio vaasid ja Anna Siedlecka ning Radek Achramoviczi täispuhutavad valgustid

  14. Armastus esimesest pilgust / Ene Vool

    Index Scriptorium Estoniae

    Vool, Ene, 1948-

    2005-01-01

    Annika Tederi jaapani stiilis aiast kui tähtsast osast eluruumis, mille kujundamisel on abiks olnud Liina Rehepapp. Jaapani aedadest, jaapanlaste suhtumisest aiakunsti ja lisaks artikkel "Eriilmelised ja -otstarbelised jaapani aiad"

  15. Comment on "An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model" by C. E. Puerto Galvis and V. V. Kouznetsov, Org. Biomol. Chem., 2013, 11, 407.

    Science.gov (United States)

    Zubkov, F I; Kvyatkovskaya, E A; Nikitina, E V; Amoyaw, P N-A; Kouznetsov, V V; Lazarenko, V A; Khrustalev, V N

    2017-08-02

    It has been proved that the reaction between furfuryl amines and N-R-maleimides leads to the formation of aza-Michael addition products - 3-(furylmethylamino)-N-R-pyrrolidine-2,5-diones, instead of 7-oxa-2-azabicyclo[2.2.1]hept-5-enes, as this journal reported previously.

  16. Synthesis and Evaluation of in Vitro Biological Activity of 4-Substituted Arylpiperazine Derivatives of 1,7,8,9-Tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

    Directory of Open Access Journals (Sweden)

    David Collu

    2009-12-01

    Full Text Available A series of twenty arylpiperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared. These derivatives were tested in vitro with the aim of identifying novel lead compounds active against emergent and re-emergent human and cattle infectious diseases (AIDS, hepatitis B and C, tuberculosis, bovine viral diarrhea. In particular, these compounds were evaluated in vitro against representatives of different virus classes, such as a HIV-1 (Retrovirus, a HBV (Hepadnavirus and the single-stranded RNA+ viruses Yellow fever virus (YFV and Bovine viral diarrhea virus (BVDV, both belonging to the Flaviridae. Compounds 2c, 2g and 3d showed a modest activity against CVB-2. The molecular structures of the starting imide 1 and one of propyl-piperazine derivatives, 3b, have been determined by an X-ray crystallography study.

  17. Clinical efficacy of implementing Bio Immune(G)ene MEDicine in the treatment of chronic asthma with the objective of reducing or removing effectively corticosteroid therapy: A novel approach and promising results.

    Science.gov (United States)

    Glady, Gilbert

    2018-06-01

    Asthma is one of the diseases that demonstrates a wide range of variation in its clinical expression, in addition to an important heterogeneity in the pathophysiological mechanisms present in each case. The ever-increasing knowledge of the molecular signalling routes and the development of the Bio Immune(G)ene Medicine [BI(G)MED] therapy in line with this knowledge has revealed a whole novel potential set of self-regulation biological molecules, that may be used to promote the physiological immunogenic self-regulation mechanisms and re-establish the homeostatic balance at a genomic, proteomic and cellular level. The aim of the present study is to demonstrate that the sublingual use of a therapeutic protocol based on BI(G)MED regulatory BIMUREGs in the treatment of chronic asthma may reduce or suppress corticosteroid therapy and avoid its harmful side effects which some patients suffer when using this treatment on a long-term basis. The clinical efficacy of BI(G)MED for chronic asthma was evaluated through a multi-centre study carried out in 2016 implementing a 6-month BI(G)MED treatment protocol for Bronchial Asthma. A total of 61 patients from private medical centres and of European countries including Germany, Austria, France, Belgium and Spain participated. The manuscript describes in detail the clinical efficacy of Bio Immune(G)ene regulatory BI(G)MED treatment protocol that allows the reduction or total removal of the corticosteroid dose in patients with chronic asthma. No adverse reactions were observed. The BI(G)MED regulatory therapy brings novel therapeutic possibilities as an effective and safe treatment of chronic asthma. BI(G)MED was demonstrated to significantly reduce asthma severity when parameter compositions were all analysed by categorical outcomes. Therefore, it is considered a good therapeutic alternative for patients who respond poorly to steroids.

  18. Code of Practice for Organic Food Processing. With contributions from Ursula Kretzschmar, Angelika Ploeger and Otto Schmid.

    OpenAIRE

    Beck, Alexander

    2006-01-01

    The consumers of “low input” and organic foods have specific expectations with respect to quality parameters of processed food. These may relate to the degree of processing, concern about specific additives, nutritional composition, integrity or whole food concepts, the degree of convenience, the level of energy use and transportation distances, but also to food safety. For many processors, fulfilling all of these expectations represents a tremendous challenge in understanding and impleme...

  19. Rhodium-catalyzed [5 + 2 + 1] cycloaddition of ene-vinylcyclopropanes and CO: reaction design, development, application in natural product synthesis, and inspiration for developing new reactions for synthesis of eight-membered carbocycles.

    Science.gov (United States)

    Wang, Yi; Yu, Zhi-Xiang

    2015-08-18

    Practical syntheses of natural products and their analogues with eight-membered carbocyclic skeletons are important for medicinal and biological investigations. However, methods and strategies to construct the eight-membered carbocycles are limited. Therefore, developing new methods to synthesize the eight-membered carbocycles is highly desired. In this Account, we describe our development of three rhodium-catalyzed cycloadditions for the construction of the eight-membered carbocycles, which have great potential in addressing the challenges in the synthesis of medium-sized ring systems. The first reaction described in this Account is our computationally designed rhodium-catalyzed two-component [5 + 2 + 1] cycloaddition of ene-vinylcyclopropanes (ene-VCPs) and CO for the diastereoselective construction of bi- and tricyclic cyclooctenones. The design of this reaction is based on the hypothesis that the C(sp(3))-C(sp(3)) reductive elimination of the eight-membered rhodacycle intermediate generated from the rhodium-catalyzed cyclopropane cleavage and alkene insertion, giving Wender's [5 + 2] cycloadduct, is not easy. Under CO atmosphere, CO insertion may occur rapidly, converting the eight-membered rhodacycle into a nine-membered rhodacycle, which then undergoes an easy C(sp(2))-C(sp(3)) reductive elimination process and furnishes the [5 + 2 + 1] product. This hypothesis was supported by our preliminary DFT studies and also served as inspiration for the development of two [7 + 1] cycloadditions: the [7 + 1] cycloaddition of buta-1,3-dienylcyclopropanes (BDCPs) and CO for the construction of cyclooctadienones, and the benzo/[7 + 1] cycloaddition of cyclopropyl-benzocyclobutenes (CP-BCBs) and CO to synthesize the benzocyclooctenones. The efficiency of these rhodium-catalyzed cycloadditions can be revealed by the application in natural product synthesis. Two eight-membered ring-containing natural products, (±)-asterisca-3(15),6-diene and (+)-asteriscanolide, have been

  20. N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry.

    Science.gov (United States)

    Wencewicz, Timothy A; Yang, Baiyuan; Rudloff, James R; Oliver, Allen G; Miller, Marvin J

    2011-10-13

    The discovery, syntheses, and structure-activity relationships (SAR) of a new family of heterocyclic antibacterial compounds based on N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds are described. A structurally diverse library of ∼100 heterocyclic molecules generated from Lewis acid-mediated nucleophilic ring-opening reactions with nitroso Diels-Alder cycloadducts and nitroso ene reactions with substituted alkenes was evaluated in whole cell antibacterial assays. Compounds containing the N-alkyl-N-(pyridin-2-yl)hydroxylamine structure demonstrated selective and potent antibacterial activity against the Gram-positive bacterium Micrococcus luteus ATCC 10240 (MIC(90) = 2.0 μM or 0.41 μg/mL) and moderate activity against other Gram-positive strains including antibiotic resistant strains of Staphylococcus aureus (MRSA) and Enterococcus faecalis (VRE). A new synthetic route to the active core was developed using palladium-catalyzed Buchwald-Hartwig amination reactions of N-alkyl-O-(4-methoxybenzyl)hydroxylamines with 2-halo-pyridines that facilitated SAR studies and revealed the simplest active structural fragment. This work shows the value of using a combination of diversity-oriented synthesis (DOS) and parallel synthesis for identifying new antibacterial scaffolds.

  1. Zinc(II PVC-based membrane sensor based on 5,6-benzo-4,7,13,16,21,24- hexaoxa-1,10-diazabicyclo[8,8,8]hexacos-5-ene

    Directory of Open Access Journals (Sweden)

    Zamani Hassan Ali

    2006-01-01

    Full Text Available The 5,6-benzo-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8,8,8]hexacos-5-ene (BHDE was used as an excellent ionophore in construction of a Zn(II PVC-based membrane sensor. The best performance was obtained with a membrane composition of 30% poly(vinyl chloride, 64.5% nitrobenzen (NB, 2.5% BHDE and 3% sodium tetraphenylborate (NaTPB. This sensor shows very good selectivity and sensitivity towards zinc ion over a wide variety of cations, including alkali, alkaline earth, transition and heavy metal ions. The sensor revealed a great enhancement in selectivity coefficients for zinc ions, in comparison to the previously reported zinc sensors. The proposed sensor exhibits a Nernstian behavior (with slope of 29.1 ? 0.4 mV per decade over a wide concentration range (1.0 10-6-1.0 10-1 mol L-1 with a detection limit of 6.3 x10-7 mol L-1 (41.2 ng mL-1. It shows relatively fast response time, in the whole concentration range (< 10s, and can be used for at least 10 weeks in a pH range of 2.8-7.3. The proposed sensor was successfully used in direct determination of zinc ions in wastewater of industrial zinc electroplating companies, and also as an indicator electrode in titration with EDTA.

  2. New optically active and thermally stable poly(amide-imide)s containing N,N'-(Bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic)-bis-L-alanine and aromatic diamines: synthesis and characterization

    Energy Technology Data Exchange (ETDEWEB)

    Faghihi, Khalil; Absalar, Morteza; Hajibeygi, Mohsen [Arak University (Iran, Islamic Republic of). Faculty of Science. Organic Polymer Chemistry Research Lab.

    2009-07-01

    Five new optically active poly(amide-imide)s (PAIs) 6a-e were prepared by direct polycondensation reaction of the newly synthesized N,N'-(bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetra carboxylic)-bis-L-alanine 4 with various aromatic diamines 5a-e using polar aprotic solvents such as N-methyl-2-pyrrolidone (NMP). In this technique triphenyl phosphite (TPP) and pyridine were used as condensing agents to form poly(amide-imide)s through the N-phosphonium salts of pyridine. All of the polymers were obtained in quantitative yields with inherent viscosities between 0.29-0.46 dL g{sup -1} and were highly soluble in polar aprotic solvents such as N,N-dimethyl acetamide (DMAc), N,N-dimethyl formamide (DMF), dimethyl sulfoxide (DMSO), N-methyl- 2-pyrrolidone (NMP) and solvents such as sulfuric acid. They were fully characterized by means of {sup 1}H NMR, FTIR spectroscopy, elemental analyses, inherent viscosity, solubility test, specific rotation and thermal properties of these polymers were investigated using thermogravimetric analysis techniques (TGA and DTG). (author)

  3. New optically active and thermally stable poly(amide-imide)s containing N,N'-(Bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic)-bis-L-alanine and aromatic diamines: synthesis and characterization

    International Nuclear Information System (INIS)

    Faghihi, Khalil; Absalar, Morteza; Hajibeygi, Mohsen

    2009-01-01

    Five new optically active poly(amide-imide)s (PAIs) 6a-e were prepared by direct polycondensation reaction of the newly synthesized N,N'-(bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetra carboxylic)-bis-L-alanine 4 with various aromatic diamines 5a-e using polar aprotic solvents such as N-methyl-2-pyrrolidone (NMP). In this technique triphenyl phosphite (TPP) and pyridine were used as condensing agents to form poly(amide-imide)s through the N-phosphonium salts of pyridine. All of the polymers were obtained in quantitative yields with inherent viscosities between 0.29-0.46 dL g -1 and were highly soluble in polar aprotic solvents such as N,N-dimethyl acetamide (DMAc), N,N-dimethyl formamide (DMF), dimethyl sulfoxide (DMSO), N-methyl- 2-pyrrolidone (NMP) and solvents such as sulfuric acid. They were fully characterized by means of 1 H NMR, FTIR spectroscopy, elemental analyses, inherent viscosity, solubility test, specific rotation and thermal properties of these polymers were investigated using thermogravimetric analysis techniques (TGA and DTG). (author)

  4. Ring opening of 2-aza-3-borabicyclo[2.2.0]hex-5-ene, the Dewar form of 1,2-dihydro-1,2-azaborine: stepwise versus concerted mechanisms

    Directory of Open Access Journals (Sweden)

    Holger F. Bettinger

    2013-04-01

    Full Text Available The ring opening of the Dewar form of 1,2-dihydro-1,2-azaborine, 2-aza-3-borabicyclo[2.2.0]hex-5-ene (3 is investigated by theoretical methods by using multiconfiguration SCF (CASSCF and coupled cluster theory [CCSD(T] with basis sets up to polarised quadruple-zeta quality. The title compound was previously reported to form photochemically in cryogenic noble gas matrices from 1,2-dihydro-1,2-azaborine (4. Four reaction paths for the thermal ring opening of 3 to 4 could be identified. These are the conventional disrotatory and conrotatory electrocyclic ring-opening pathways where the BN unit is only a bystander. Two more favourable paths are stepwise and involve 1,3-boron–carbon interactions. The lowest energy barrier for the isomerisation reaction, 22 kcal mol−1, should be high enough for an experimental observation in solution. However, in solution the dimerisation of 3 is computed to have a very low barrier (3 kcal mol−1, and thus 3 is expected to be a short-lived reactive intermediate.

  5. The traditional medicine Spilanthes acmella, and the alkylamides spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, demonstrate in vitro and in vivo anti-malarial activity

    Science.gov (United States)

    Spelman, Kevin; Depoix, Delphine; McCray, Megan; Mouray, Elisabeth; Grellier, Philippe

    2010-01-01

    Spilanthes spp. are used as traditional herbal medicines in Africa and India to treat malaria. Yet, to date, there is no data on active constituents or most effective extraction methods for this indication. The isolated alkylamides, spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, found in S. acmella Murr., were shown to have IC50s of 16.5 μg/mL and 41.4 μg/mL on Plasmodium falciparum strain PFB and IC50s of 5.8 μg/mL and 16.3 μg/mL for the chloroquine resistant P. falciparum K1 strain, respectively. Further investigations revealed that at relatively low concentrations, spilanthol and the water extract of S. acmella reduced the parasitemia 59% and 53% in mice infected with P. yoelii yoelii 17XNL at 5 mg/kg and 50 mg/kg, respectively. Unexpectedly, the 95% ethanol extract of S. acmella was less effective (36% reduction in parasitemia) at 50 mg/kg. These results provide the first evidence supporting S. acmella against malaria and demonstrating active constituents in S. acmella against P. falciparum. PMID:22692989

  6. Kohustus kannatada, et näha ja mõista. Ene Mihkelsoni ja Ingeborg Bachmanni kirjanikunägemus. The Writer’s Duty to Suffer in Order to See and Understand: The Literary Vision of Ene Mihkelson and Ingeborg Bachmann

    Directory of Open Access Journals (Sweden)

    Aija Sakova

    2012-04-01

    Full Text Available In an interview from 1971 the Austrian poet and author Ingeborg Bachmann (b 1923 said that there are phenomena that science and scientific language cannot explain. According to her these are the phenomena that belong to the realm of writers and literature. In the same year Ene Mihkelson (b 1946, who had not yet published a single book of poetry or a novel because of censorship, pondered on the role of the author within society: “The author digs under the surface and the author’s responsibility to society lies in his/her persistence, in his/her duty to suffer, to endure stress, which the people in the midst of their busy, daily lives are unable to fully grasp.” Responsibility to society and the duty to suffer and explore the deepest layers below the surface are common to both Mihkelson and Bachmann. Both writers were born and grew up in the shadow of war, violence and totalitarianism. Mihkelson was brought up in a guerrilla family in Soviet Estonia; Bachmann spent her childhood years growing up in the Nationalist-Socialist Austria and in her youth she witnessed the Second World War and its catastrophic consequences. So both of them understand that as writers they cannot overlook the events that they had, either directly or indirectly, witnessed. In an interview from 2009 Mihkelson said that the fact that she remained alive while many did not, that she was not deported to Siberia although it could have happened, has obligated her to write and reflect on what had happened. No consensus has been reached in Europe to condemn Communism as a crime against humanity, but for Estonians Communism and the 50 years of Soviet regime signify a lengthy experience of a totalitarian regime and, in spite of a possible opposition from German-speaking cultures, Communism very often equals Nazism in Estonia. According to Mihkelson, in order to understand and reflect this experience it is not sufficient to rely only on the archives, biographies and books of

  7. Androgen and Progesterone Receptors Are Targets for Bisphenol A (BPA, 4-Methyl-2,4-bis-(P-HydroxyphenylPent-1-Ene--A Potent Metabolite of BPA, and 4-Tert-Octylphenol: A Computational Insight.

    Directory of Open Access Journals (Sweden)

    Mohd Rehan

    Full Text Available Exposure to toxic industrial chemicals that have capacity to disrupt the endocrine system, also known as endocrine disrupting chemicals (EDCs, has been increasingly associated with reproductive problems in human population. Bisphenol A (BPA; 4,4'-(propane-2,2-diyldiphenol and 4-tert-octylphenol (OP; 4-(1,1,3,3-tetramethylbutylphenol are among the most common environmental contaminants possessing endocrine disruption properties and are present in plastics, epoxy resins, detergents and other commercial products of common personal and industrial use. A metabolite of BPA, 4-Methyl-2,4-bis(4-hydroxyphenylpent-1-ene (MBP is about 1000 times more biologically active compared to BPA. Epidemiological, clinical, and experimental studies have shown association of BPA and OP with adverse effects on male and female reproductive system in human and animals. The endocrine disruption activity can occur through multiple pathways including binding to steroid receptors. Androgen receptor (AR and progesterone receptor (PR are critical for reproductive tract growth and function. Structural binding characterization of BPA, MBP, and OP with AR and PR using molecular docking simulation approaches revealed novel interactions of BPA with PR, and MBP and OP with AR and PR. For BPA, MBP, and OP, five AR interacting residues Leu-701, Leu-704, Asn-705, Met-742, and Phe-764 overlapped with those of native AR ligand testosterone, and four PR interacting residues Leu-715, Leu-718, Met-756, and Met-759 overlapped with those of PR co-complex ligand, norethindrone. For both the receptors the binding strength of MBP was maximum among the three compounds. Thus, these compounds have the potential to block or interfere in the binding of the endogenous native AR and PR ligands and, hence, resulting in dysfunction. The knowledge of the key interactions and the important amino-acid residues also allows better prediction of potential of xenobiotic molecules for disrupting AR- and PR

  8. Situación de riesgo y salud de los adolescentes en el valle de los ríos Apurímac, Ene y Mantaro en Perú

    Directory of Open Access Journals (Sweden)

    Fabiola Yeckting Vilela

    Full Text Available Se presenta el diagnóstico de las condiciones de vida de los adolescentes varones y mujeres en la zona del valle de los ríos Apurímac, Ene y Mantaro (VRAEM, quienes atraviesan situaciones de riesgo y vulnerabilidad social y sexual debido a los altos niveles de producción de la hoja de coca y el contexto del narcotráfico, que crean la ilusión del rápido ascenso social. A partir de ello, es necesario preguntarse ¿cuáles son las condiciones de vida y situaciones de riesgo de los adolescentes en el VRAEM? y ¿cuáles son las alternativas para una mejora de su situación desde el acceso a la educación y los programas de atención de su salud? Esta situación de riesgo es el resultado de las relaciones desiguales de género, violencia sexual, deserción escolar, embarazo adolescente, consumo de alcohol y drogas, así como de la falta de oportunidades como consecuencia de la participación en la economía de la coca y el narcotráfico entre los adolescentes en el VRAEM. Finalmente, se presentan los resultados de la atención de profesionales de los centros de salud para favorecer la consejería en salud sexual y reproductiva y el acceso a los servicios de salud del Programa Vida Adolescente, como oportunidad de vincular los contenidos del currículo de educación y las metas de cumplimiento de este sector, visibilizando la necesidad de un enfoque de interculturalidad e igualdad de género en el acceso a la salud y la educación de los adolescentes.

  9. Effect of tibolone and its principal metabolites (3α- and 3β-hydroxy, 3α-sulfate, and 4-ene derivatives) on estrone sulfatase activity in normal and cancerous human breast tissue.

    Science.gov (United States)

    Chetrite, Gérard S; Cortes-Prieto, Joaquin; Pasqualini, Jorge R

    2011-12-01

    Tibolone (Org-OD14) is the active substance of Livial®, a synthetic steroid with the structure 7α,17α-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one, possessing weak tissue-specific estrogenic, progestogenic, and androgenic properties, used to treat menopausal complaints. After oral administration, tibolone is extensively metabolized into the 3α-(Org-4904) and 3β-(Org-30126) hydroxy derivatives with estrogenic properties, its 4-ene (Org-OM38) isomer with progestogenic/androgenic activities, and the 3α-sulfate (Org-34322) derivative, a major biologically inactive circulating form. We compared the dose response of tibolone and its metabolites on estrone sulfatase activity [conversion of estrone sulfate (E1S) to estrone (E1)] in normal and cancerous human breast tissues. Tissue minces were incubated with physiological concentrations of [3H]-E1S (5×10-9M) alone or in the presence of tibolone and its metabolites (concentration range: 5×10-7to 5×10-5M) for 4 h. Tritiated E1, estradiol (E2), and E1S were separated and evaluated quantitatively by thin-layer chromatography. The sulfatase activity was significantly higher in cancerous breast but strongly inhibited by tibolone and the different metabolites, whereas 3α- and 3β-hydroxy derivatives were the most potent inhibitors. This very significant inhibitory effect of tibolone and its principal metabolites on the enzyme involved in E2biosynthesis in the human breast provides interesting perspectives to study the biological responses of these compounds in trials with breast cancer patients.

  10. Crystal structures of three anhydrous salts of the Lewis base 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU with the ring-substituted benzoic acid analogues 4-aminobenzoic acid, 3,5-dinitrobenzoic acid and 3,5-dinitrosalicylic acid

    Directory of Open Access Journals (Sweden)

    Graham Smith

    2016-03-01

    Full Text Available The anhydrous salts of the Lewis base 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU with 4-aminobenzoic acid [1-aza-8-azoniabicyclo[5.4.0]undec-7-ene 4-aminobenzoate, C9H17N2+·C7H6NO2− (I], 3,5-dinitrobenzoic acid [1-aza-8-azoniabicyclo[5.4.0]undec-7-ene 3,5-dinitrobenzoate, C9H17N2+·C7H3N2O6−, (II] and 3,5-dinitrosalicylic acid (DNSA [1-aza-8-azoniabicyclo[5.4.0]undec-7-ene 2-hydroxy-3,5-dinitrobenzoate, C9H17N2+·C7H3N2O7−, (III] have been determined and their hydrogen-bonded structures are described. In both (II and (III, the DBU cations have a common disorder in three of the C atoms of the six-membered ring moieties [site-occupancy factors (SOF = 0.735 (3/0.265 (3 and 0.686 (4/0.314 (4, respectively], while in (III, there is additional rotational disorder in the DNSA anion, giving two sites (SOF = 0.72/0.28, values fixed for the phenol group. In the crystals of (I and (III, the cation–anion pairs are linked through a primary N—H...Ocarboxyl hydrogen bond [2.665 (2 and 2.869 (3 Å, respectively]. In (II, the ion pairs are linked through an asymmetric three-centre R12(4, N—H...O,O′ chelate association. In (I, structure extension is through amine N—H...Ocarboxyl hydrogen bonds between the PABA anions, giving a three-dimensional structure. The crystal structures of (II and (III are very similar, the cation–anion pairs being associated only through weak C—H...O hydrogen bonds, giving in both overall two-dimensional layered structures lying parallel to (001. No π–π ring associations are present in any of the structures.

  11. 7-{[2-(4-Hydroxyphenylmethylidene]amino}-1,3-thiazol-4-yl-2-(methoxyiminoacetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-ylsulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

    Directory of Open Access Journals (Sweden)

    Ghulam Fareed

    2012-05-01

    Full Text Available Novel 7-{[2-(4-hydroxyphenylmethylidene]amino}-1,3-thiazol-4-yl-2-(methoxyiminoacetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-ylsulfanyl]methyl}-8-oxo-5-thia-1azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid was prepared by condensation of ceftriaxone disodium (1 with 4-hydroxybenzaldehyde (2 in ethanol under reflux conditions for 3–4 h. The structure of synthesized compound was elucidated using LCMS, 1H-NMR, and CHN techniques.

  12. 6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.

    Science.gov (United States)

    Kuntze, Kevin; Shinoda, Yoshifumi; Moutakki, Housna; McInerney, Michael J; Vogt, Carsten; Richnow, Hans-Hermann; Boll, Matthias

    2008-06-01

    In anaerobic bacteria, most aromatic growth substrates are channelled into the benzoyl-coenzyme A (CoA) degradation pathway where the aromatic ring is dearomatized and cleaved into an aliphatic thiol ester. The initial step of this pathway is catalysed by dearomatizing benzoyl-CoA reductases yielding the two electron-reduction product, cyclohexa-1,5-diene-1-carbonyl-CoA, to which water is subsequently added by a hydratase. The next two steps have so far only been studied in facultative anaerobes and comprise the oxidation of the 6-hydroxyl-group to 6-oxocyclohex-1-ene-1-carbonyl-CoA (6-OCH-CoA), the addition of water and hydrolytic ring cleavage yielding 3-hydroxypimelyl-CoA. In this work, two benzoate-induced genes from the obligately anaerobic bacteria, Geobacter metallireducens (bamA(Geo)) and Syntrophus aciditrophicus (bamA(Syn)), were heterologously expressed in Escherichia coli, purified and characterized as 6-OCH-CoA hydrolases. Both enzymes consisted of a single 43 kDa subunit. Some properties of the enzymes are presented and compared with homologues from facultative anaerobes. An alignment of the nucleotide sequences of bamA(Geo) and bamA(Syn) with the corresponding genes from facultative anaerobes identified highly conserved DNA regions, which enabled the discrimination of genes coding for 6-OCH-CoA hydrolases from those coding for related enzymes. A degenerate oligonucleotide primer pair was deduced from conserved regions and applied in polymerase chain reaction reactions. Using these primers, the expected DNA fragment of the 6-OCH-CoA hydrolase genes was specifically amplified from the DNA of nearly all known facultative and obligate anaerobes that use aromatic growth substrates. The only exception was the aromatic compound-degrading Rhodopseudomonas palustris, which uniquely uses a modified benzoyl-CoA degradation pathway. Using the oligonucleotide primers, the expected DNA fragment was also amplified in a toluene-degrading and a m

  13. Modernne kastmaja Nõmmel / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    1999-01-01

    Projekteerija: arhitektuuribüroo Mark & Tamm. Konstruktiivne osa: inseneribüroo Randväli Karema. Arhitektid Ülar Mark, Kalle Komissarov. Kahekorruseline maja Vabaduse pst. ääres on mahutatud puude vahele kitsale alale. Kommenteerib Ü. Mark.

  14. Professor Pekka Puska loengud / Ene Indermitte

    Index Scriptorium Estoniae

    Indermitte, Ene, 1967-

    2004-01-01

    Soome Rahvatervishoiu Instituudi direktor, Põhja-Karjala projekti juht prof Pekka Puska peab Tartu ülikoolis loengu "The North Karelia Projekt in Finland and lessons for global chronic disease prevention"

  15. Maia Laul / Maia Laul ; interv. Ene Ammer

    Index Scriptorium Estoniae

    Laul, Maia, 1921-2009

    1998-01-01

    Maia Laul eriala omandamisest, õppejõududest. Lõpetas 1949. a. Tallinna Riikliku Tarbekunsti Instituudi. Alar Kotli käealusena "Estonia" teatri taastamisprojekti juures. Peeter Tarvase ja August Volbergiga ENSV paviljponi kujundamas Moskvas VDNHs. Töötamisest ARSis. Sisearhitektuur ja monumentaalkunst (koostöö Eva Jänesega). Esinemistest näitustel "Ruum ja vorm". Ühiskondlike hoonete sisekujundustest. Vanaturu apteek (klaasigraafika Tiit Jürna)

  16. Riik arhitektuuritellijana / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2010-01-01

    Näidete varal Riigi Kinnisvara AS-i korraldatud projekteerimise hangetest, mil välja valiti odavaim pakkumine. Valminud Rakvere politseihoonest ning Jõgeva kohtu- ja politseihoonest. Mudelprojekteerimise (BIM) nõudest. Riigihankest kui salastatud protsessist. Sunnist loobuda autoriõigusest. Riigihankega ühendatud arhitektuurikonkursist

  17. Küberjulgeolekule teed rajades / Ene Ergma

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2007-01-01

    Riigikogu esimees analüüsib aprillisündmustega kaasnenud küberrünnakute kui ühe terrorismi erivormi tagamaid, toob välja vajaduse kujundada küberrünnakute suhtes Euroopa Liidus ja NATO-s ühtne poliitika

  18. Juugendit armastav 21. sajandi kodu / Ene Vool

    Index Scriptorium Estoniae

    Vool, Ene, 1948-

    2006-01-01

    Kaunisse ümbrusse ehitatud stiilne maja, mille projekteeris Margit Kõrts. Sisustus, valgustid ja mööbel on juugendstiilis ja Kadri Tarbe-Pärtelpoeg projekteeris sobiva trepivõre ning trafarettmaalingu tegi Ruth Tuvike, kopeerides Alphonse Maria Mucha seinamaalingut. Mirjam Peili kommentaar

  19. Tagasivaade elule ja ajale / Ene Liivik

    Index Scriptorium Estoniae

    Liivik, Ene, 1933-

    2010-01-01

    Artikkel põhineb kahel käsikirjal "Tagasi waade möödunud elule ja ajale. Utškuju-Tarhani küla aja lugu. 50ne aastane juubel" ja "Lahtised lehed", mille autoriks on Helmi Koolmann. Käsikirjas meenutavad Helmi ja tema abikaasa Rein Koolmann Krimmis elatud aastaid

  20. Uus eesti disain / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2009-01-01

    2009. a. disainiöö raames toimunud Eesti Disainerite Liidu algatatud konkursi "Eesti disain ja elukeskond 2009" disainikategooria kümne finalisti tööde tutvustus. 1. koha sai moodulrattahoidja "Rohi" (disain: Keha3), 2. koha vurr-tool "Kiirendi" (disain: Jaanus Orgusaar), 3. koha lastemööbel "Smart kid" (disain: Pavel Sidorenko, Heiki Must)

  1. ŽENE U ZNANOSTI: STAKLENI STROP

    OpenAIRE

    PRIJIĆ-SAMARŽIJA, Snježana; AVELINI HOLJEVAC, Ivanka; TURK, Marko

    2009-01-01

    Temeljni cilj članka jest propitivanje postojanja "staklenoga stropa" ili podzastupljenosti žena na rukovodećim položajima u ustanovama znanosti i visokog obrazovanja kakvo je Sveučilište u Rijeci, uključivo i mehanizama koji ga uzrokuju. Prvi dio članka sadrži kratak pregled i analizu empirijskih rezultata istraživanja provedenog na Sveučilištu u Rijeci, koji nedvojbeno upućuju na prisutnost efekta "staklenoga stropa" i, shodno tome, na postojanje prikrivene primarne i s...

  2. Mida lugeja raamatukogult tegelikult ootab / Ene Riet

    Index Scriptorium Estoniae

    Riet, Ene, 1954-

    2011-01-01

    4. teadus- ja erialaraamatukogude päev toimus 21. oktoobril 2011 Eesti Muusika- ja Teatriakadeemias. Teadusraamatukogu aasta teo auhinna pälvis Urmas Sinisalu tulemusliku ja innovaatilise töö eest raamatukogude infosüsteemi ESTER arendamisel. Erialaraamatukogu aasta teo auhinna sai TÜ ajakirjanduse ja kommunikatsiooni instituudi raamatukoguhoidja Maio Vaniko raamatukogundust arendava tegevuse eest

  3. Tohuvabohu kodukujunduses / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Tänapäeva Eesti kodukujundusest. Illustratsiooniks 90ndate kolm eramut : neomodernistlik Sinine Maja neominimalistliku interjööriga (Kolm Pluss Üks Arhitektid, arhitekt M. Kaasik), modernistlik villa Sumberg - (Urbel & Peil, arhitekt E. Urbel, sisekujundaja T. Mähar), ökosugemetega modernistlik villa Koger (arhitekt V. Sova, sisearhitektid A. Teigar, M. Press). Kommenteerivad Mart Kalm, Toivo Raidmets. Terminite selgitus.

  4. Ametlikke annetusi 2005. aastal / Ene Riet

    Index Scriptorium Estoniae

    Riet, Ene, 1954-

    2005-01-01

    Saksamaa suursaadik Julius Bobinger kinkis 50 saksakeelset "Kalevipoega" Eesti Kultuuriministeeriumile, kes edastas need maakonnaraamatukogudele, teadusraamatukogudele ja Kreutzwaldi muuseumile Võrus

  5. Vaesusriski muutused Eestis / Ene-Margit Tiit

    Index Scriptorium Estoniae

    Tiit, Ene-Margit, 1934-

    2006-01-01

    Seoses Eesti majanduse kiire arenguga tellis sotsiaalministeerium 2005. aastal uue tarbimiskaalude hinnangu, mille aluseks olid leibkonna eelarvehinnangu andmed aastaist 2000-2004 ning hinnati erineva struktuuriga leibkondade tarbimiskulutusi. Diagrammid. Graafikud

  6. Eesti Etnograafia Ring Kanadas / Ene Runge

    Index Scriptorium Estoniae

    Runge, Ene, 1919-1999

    1993-01-01

    Etnograafia Ring looodi 1971.a ja on pidevalt õpetanud käsitööd, pidanud loenguid eesti ja inglise keeles, korraldanud näitusi ja loonud eesti sektsiooni Royal Ontario Museumi ja Canadian National Museumi juurde kultuurivara säilitamiseks. Seltsi 20. aastapäevaks oli välja antud 61 õppekirja, lisaks õpetused ajakirjas "Triinu" ja õppefilmid, fotod ja diapositiivid, abi on antud samasugustele ringidele Rootsis ja Austraalias, ERM-ile saadeti 1991. a üle 200 rahvakultuuri eseme

  7. Cultural Trauma and Life Stories / Ene Kõresaar

    Index Scriptorium Estoniae

    Kõresaar, Ene

    2007-01-01

    Aili Aarelaid-Tarti 15-aastase uuringu tulemused raamatus "Cultural Trauma and Life Stories", Hesinki, Kikimora Publications, 2006. Uuritud on kolme suurt rahvusgruppi 1940-test tingitud trauma kontekstis: eestlased kodumaal, eestlased eksiilis ja venekeelne rahvusgrupp Eestis postsovetlikus diskursuses

  8. Seadusemuudatused, mis teevad elu paremaks / Ene Kaups

    Index Scriptorium Estoniae

    Kaups, Ene, 1963-

    2008-01-01

    2008. aastal jõustuvatest seadusemuudatustest. Ilmunud ka Koit 7. veeb. 2008, lk. 6 ; Lääne Elu 7. veeb. 2008, lk. 2 ; Hiiu Leht 8. veeb. 2008, lk. 2 ; Järva Teataja 9. veeb. 2008, lk. 2 ; Türi Rahvaleht 8. veeb. 2008, lk. 4, pealkiri kujul: Seadusemuudatustest ; Meie Maa 15. veeb. 2008, lk. 2 ; Sakala 15. veeb. 2008, lk. 2, pealkiri kujul: Käesolev aasta toob hulga olulisi muudatusi ; Sõnumitooja 27. veeb. 2008, lk. 2 ; Valgamaalane 26. veeb. 2008, lk. 2

  9. Ene-ene-yne Reactions: Activation Strain Analysis and Role of Aromaticity

    NARCIS (Netherlands)

    Fernandez, I.; Bickelhaupt, F.M.; Cossío, F.P.

    2014-01-01

    The trend in reactivity of the thermal cycloisomerization reactions of 1,3-hexadien-5-ynes, A=B-C=D-E≡F, were explored and analyzed by using density functional theory at the M06-2X/def2-TZVPP level. These reactions proceed through formally aromatic transition states to form a bent-allene

  10. Tuul väljal / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet

    1997-01-01

    Arvustus: Woolf, Virginia. Esseed/ inglise k. tlk. Malle Talvet, Jaak Rähesoo. Tallinn : Hortus Litterarum, 1997; Woolf, Virginia. Orlando : elulugu / inglise k. tlk. Riina Jesmin. Tallinn : Perioodika, 1997. (Loomingu Raamatukogu; 31-34)

  11. ŽENE I SPORT U CRNOJ GORI

    OpenAIRE

    Cheryl Cooky; Marko Begović; Don Sabo; Carole Oglesby; Marj Snyder

    2011-01-01

    This paper is part of a larger study that identifies who plays sport in Montenegro, and the factors (family, education, economic, religious, cultural stereotypes, and so on) that contribute to girls and women’s participation in sport or that limit girls and women’s participation in sport. This study is the first evidencebased research assessing the current status of girls and women’s sport participation in Montenegro, at all institutional levels. Using mixed-methodologies (quantitative assess...

  12. Schone Handen: als de ene hand de andere wast

    NARCIS (Netherlands)

    C.H.J. van Eijck (Casper)

    2010-01-01

    textabstractRede, in verkorte vorm uitgesproken ter gelegenheid van het aanvaarden van het ambt van bijzonder hoogleraar met als leeropdracht Chirurgie met specifieke aandacht voor het pancreas, aan het Erasmus MC, faculteit van de Erasmus Universiteit Rotterdam op 25 juni 2010

  13. Ülikool ja haridus postajastul / Ene Grauberg

    Index Scriptorium Estoniae

    Grauberg, Ene, 1944-

    2006-01-01

    Informatsiooni kesksest rollist postindustriaalses ühiskonnas, ülikooli ja rakenduskõrgkooli teisenenud funktsioonidest, kõrghariduse uutest trendidest, õppejõu ja üliõpilase suhete muutumisest Pransuse filosoofi Jean-Francois Lyotardi interpreteeringuga

  14. ŽENE I SPORT U CRNOJ GORI

    Directory of Open Access Journals (Sweden)

    Cheryl Cooky

    2011-08-01

    Full Text Available This paper is part of a larger study that identifies who plays sport in Montenegro, and the factors (family, education, economic, religious, cultural stereotypes, and so on that contribute to girls and women’s participation in sport or that limit girls and women’s participation in sport. This study is the first evidencebased research assessing the current status of girls and women’s sport participation in Montenegro, at all institutional levels. Using mixed-methodologies (quantitative assessment, survey data and qualitative focus group interviews this study will determine the numbers of girls and women participating in sport, as compared to boys and men in similar demographic categories, and to examine why girls and women do or do not participate in sport and what are their experiences in sport. Initial findings from the demographic assessment of sport in Montenegro illustrate overall gender disparities in sport participation in the 7 most popular sports; the majority of athletes, coaches, managers and decision-makers, medical staff, referees and sport delegates were men. We found the greatest gender imbalance in soccer and basketball, which were overwhelmingly male-dominated, and the greatest gender parity in handball and volleyball- and in some cases there were more female participants than male participants in these sports. We also examined overall trends in gender and sport participation across the different geographical regions, which were similar. However, there were differences in the types of sports men and women played in the different regions, which may indicate that some sports were more popular, or accepted, or easier to access for women in the central part of the country while other sports were more popular, or accepted or easier to access for women in the northern and southern regions. The project is a collaborative partnership with US- and Montenegro based scholars, the International Olympic Committee, the Montenegrin Olympic Committee, the United Nations Development Program, the Office for Gender Equality of the Ministry for Human and Minority Right of Montenegro, and NGO Inovativnost. Reflections and insights on multi-institutional partnerships in the study gender and sport participation will be offered.

  15. Eesti sugemetega jaapani aed / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    1999-01-01

    Ülle Grishakovi kujundatud aed Kose-Lükatil Pirita jõe käärus endise prügimäe kohal. Kahe hektari suurusel alal on esindatud jaapani aed, dekoratiiv-tarbeaed, inglise stiilis vanaema aed. 7 illustratsiooni.

  16. Lapse ülalpidamise hind / Ene-Margit Tiit

    Index Scriptorium Estoniae

    Tiit, Ene-Margit, 1934-

    2005-01-01

    Tutvustav artikkel sotsiaalministeeriumi tellimusel läbiviidud uuringust, mille eesmärgiks oli välja töötada lapse kõikidest vajadustest lähtuv ühtne metoodika lapse ülalpidamiskulude arvutamiseks ühes kuus. Tabelid. Diagrammid. Vt. ka lk. 15-16: Kaplan, Signe. Metoodika kasutamisvõimalusi

  17. 500-tonniste muldseintega elamu / Ene Läkk, Helen Urbanik

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Arhitekt Rick Joy projekteeritud arst John Palmeri villa USAs Arizona osariigis, Santa Catalina mäestiku jalamil. Hoone ühes osas asuvad perekonna eluruumid, teine on avatud ruum. Pressitud muldseinad ja liblikatiiva kujulised terasest katusesiilud jäljendavad ümbritseva maastiku vorme. Suuri seina- ja aknapindu katab raamimata klaas.

  18. Otsused andmekandjate kohta kriminaalmenetluses: proportsionaalsusnõudega arvestamine / Eneli Laurits

    Index Scriptorium Estoniae

    Laurits, Eneli

    2016-01-01

    Riigikohtu lahendist nr. 3-1-1-57-12, proportsionaalsuse nõude rakendamisest asitõendi (andmekandja) täieliku hävitamise korral alamaastmete kohtute praktikas. Sisaldab 2013-2015 aastate asjakohast kohtupraktikat

  19. Tööjuhendid loovuse arendajana / Ene Lind

    Index Scriptorium Estoniae

    Lind, Ene

    2001-01-01

    Loovuse arendamine tööõpetuse ja käsitöö tunnis. Katsest Tallinna koolide 2. ja 4. klasside õpilaste seas, milles katsetati kaht töö raskusastme ning kasutatavate materjalide ja töövahendite poolest erinevat tööjuhendit. Katse järel viidi läbi küsitlus, kus lapsed andsid hinnangu ja kommenteerisid tööjuhendi järgi iseseisvalt töötamist tööõpetuse tunnis

  20. Phytochemical Screening and Characterization of Olean-18-ene ...

    African Journals Online (AJOL)

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  1. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    DEFF Research Database (Denmark)

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet). Rappor...

  2. Episteemilise loogika mõningad aspektid / Ene Grauberg

    Index Scriptorium Estoniae

    Grauberg, Ene, 1944-

    2004-01-01

    Episteemiline loogika on modaalse loogika alasüsteemi loogika teooria, mis kasutab episteemilise operaatoreid ...teab,et..., ...eeldab,et.... Tema aineks on neid operaatoreid sisaldavate otsustuste õige organiseerimise reeglid ja tingimused. Varem ilmunud: Metod modelirovanija i nekotorõje filosofskije problemõ istorii i metodologii jestestvoznanija. Tallinn, 1975.

  3. Põllumajandussaaduste turg : [1994-2003 Eestis] / Ene Maadvere

    Index Scriptorium Estoniae

    Maadvere, Ene, 1948-

    2004-01-01

    Ilmunud ka: Agriculture and rural development : overview 2003/2004. - Tallinn, 2004, lk. 124-132. Põllumajandussaaduste ekspordimaht vähenes 2003. a. eelmise aasta sama perioodiga võrreldes 0,4%, importmaht aga suurenes 7%. Tabelid. Diagrammid. Graafikud

  4. Videomuinasjutt algastme eesti keele tundi : miks ka mitte? / Ene Peterson

    Index Scriptorium Estoniae

    Peterson, Ene

    2002-01-01

    Rets. : Tungal, Leelo. Videomuinasjutt "Printsess Mari ja konn Konrad" [Videosalvestis] = A fairytale on video "Princess Mari and frog Konrad". - Tallinn : Elav Teadus, 1993. - 1 videokassett (VHS) (120 min) + 1 raamat (32 lk.)

  5. Põllumajandussaaduste eksport ja import Eestis 1995. aastal / Ene Maadvere

    Index Scriptorium Estoniae

    Maadvere, Ene, 1948-

    1996-01-01

    Tabelid: Kaupade eksport ja import Eestis; Põhiliste kaubagruppide osatähtsuse muutumine toidukaupade ekspordis; Hinnad; Mõnede toidukaupade eksport 1995.a. võrreldes 1994.a.; Imporditud toidukaupade struktuur võrreldes 1995.a.; Nisuhind Chicago börsil. Diagrammid: Liha-piima tootmine, tarbimine, eksport ja tonnides; Põllumajandussaaduste eksport 1995.a. riikide lõikes

  6. Saarlased võitsid karaokevõistluse / Ene Kallas

    Index Scriptorium Estoniae

    Kallas, Ene

    2009-01-01

    15. veebruaril Tallinna restoranis Kännu Kõrts krooniti Annika Väälma ja Iivo Miil Eesti karaokekuningannaks ja -kuningaks, mõlemad saarlased osalevad ka 28. veebruaril Tallinnas Sokos Hotell Viru restoranis Merineitsi karaoke rahvusvahelisel võistulaulmisel "Finbaltic Karaoke King and Queen"

  7. Mentor - mis see veel on? / Ene-Silvia Sarv

    Index Scriptorium Estoniae

    Sarv, Ene-Silvia

    2001-01-01

    Mentori rollist praktikantide, kutseaastat sooritavate ja uute õpetajate juhendajana, klassijuhatajate ja aineõpetajate nõustajana, kontaktisikuna noorte õpetajate ettevalmistamisel ülikoolis. TPÜ magistrantide mentorirühma projektseminaril "Mentori roll lähituleviku Eesti koolis" ja TÜ mentorirühma õppustel olid teoreetilise põhikursuse kõrval arutusel mentorite praktilise rakendamise võimalused. Analüüsi põhjal tuletati mentorluse neli võimalikku stsenaariumi

  8. Puhtus ja kord majas ning mõtetes / Ene Vool

    Index Scriptorium Estoniae

    Vool, Ene, 1948-

    2007-01-01

    Kalle Rõõmuse projekteeritud inimese bioenergiast lähtuvast eramust, kus raudse järjekindlusega kasutati energeetilisest seisukohast ülimalt inimsõbralikke loodusmaterjale - mida vähem materjale, seda vähem väljamõjusid. Sisearhitekt oli Terje Kivist. Kalle Rõõmuse kommentaar

  9. Amphiphilic silicone architectures via anaerobic thiol-ene chemistry.

    Science.gov (United States)

    Keddie, Daniel J; Grande, John B; Gonzaga, Ferdinand; Brook, Michael A; Dargaville, Tim R

    2011-11-18

    Despite broad application, few silicone-based surfactants of known structure or, therefore, surfactancy have been prepared because of an absence of selective routes and instability of silicones to acid and base. Herein the synthesis of a library of explicit silicone-poly(ethylene glycol) (PEG) materials is reported. Pure silicone fragments were generated by the B(C(6)F(5))(3)-catalyzed condensation of alkoxysilanes and vinyl-functionalized hydrosilanes. The resulting pure products were coupled to thiol-terminated PEG materials using photogenerated radicals under anaerobic conditions.

  10. Hüdra aastasada / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet

    1997-01-01

    Arvustus: Galsworthy, John. Peatüki lõpp : Üle jõe / tlk. Jüri ja Liisi Ojamaa. Tallinn : Eesti Raamat, 1997; Amis, Kingsley. qnneseen Jim / tlk. Urve Hanko. Tallinn : Eesti Raadio, 1997; Boyd, William. Sinine pärastlõuna / tlk. Virve Krimm. Tallinn : Varrak, 1997. Briti XX saj. kirjanduse ülevaade

  11. Palkmaja mõisahäärberiks / Ene Pajula

    Index Scriptorium Estoniae

    Pajula, Ene, 1950-

    2003-01-01

    Riguldi (Rickholtzi) mõisa ajaloost, omanikest, klassitsistlikust häärberist, kõrvalhoonetest. 1967. aastast kuulub Riguldi Tallinna 1. internaatkoolile. Vana kuivati on Taubede järeltulijad tagasi ostnud ja suvemajaks ümber ehitanud. Kommentaarid Lääne maakonna arhitektilt Tõnis Padult. 10 ill

  12. Kooli tehnoloogiaõpetus tuleb atraktiivseks muuta / Ene Lind

    Index Scriptorium Estoniae

    Lind, Ene, 1954-

    2010-01-01

    Üleeuroopalisest tehnoloogiaõppe edendamise projektist "Understanding and Providing a Developmental Approach to Technology Education" - UPDATE ("Tehnoloogiaõpetuse arenguvõimaluste mõistmine ning rakendamine"). Jyväskylä Ülikooli juhtimisel tegid koostööd 16 Euroopa haridus- ja teadusasutust, Eestit esindas Tallinna Ülikooli tööõpetuse osakond koos Eesti Tehnoloogiakasvatuse Liiduga

  13. Sotsiaal-majanduslik staatus tervise tausttegurina / Margo Kikas, Ene Lausvee

    Index Scriptorium Estoniae

    Kikas, Margo

    2008-01-01

    Uuringust seoste kohta Eesti inimeste tunnetatud tervise ning sotsiaal-majandusliku ja psühhosotsiaalse seisundi vahel. Uuring tugineb Tallinna Ülikooli sotsiaaltöö eriala üliõpilaste poolt aastatel 2001-2002 tehtud anonüümsel ankeetküsitlusel põhiliselt toimetulekuraskuste, krooniliste haiguste, puudega või riskikäitumisega isikute seas

  14. People in Ida-Virumaa : between two cultures / Ene Must

    Index Scriptorium Estoniae

    Must, Ene

    2002-01-01

    Peamistest probleemidest Ida-Virumaal, Sillamäel ja Narvas. Kohalike elanike seas läbi viidud Eesti sotsioloogide, Eesti integratsioonifondi ja Saar Polli uuringufirma uurimusest, kus uuriti nende sidemeid naaberriikidega, majanduslikku olukorda ning nende võimalikku elukoha muutust seoses majandusliku olukorraga Eestis ja liitumisega EL-iga. Kokkuvõtted uuringu tulemustest. Diagrammid

  15. Ainenõukogu tähelepanekuid / Ene Laanes

    Index Scriptorium Estoniae

    Laanes, Ene

    2003-01-01

    Üleriigiline kehalise kasvatuse ainenõukogu peab vajalikuks juhtida haridusametnike, koolijuhtide ja kooli omanike tähelepanu kehalise kasvatuse ainekava läbiviimisel üles kerkinud probleemidele: meditsiinilisse erigruppi kuuluvate õpilaste hindamine kehalise kasvatuse aines, kehalise kasvatuse tunniks vajalikud harjutuspaigad ja vahendid, nädalatundide arv

  16. Fluoriidid Eesti elanike joogivees / Astrid Saava, Ene Indermitte

    Index Scriptorium Estoniae

    Saava, Astrid, 1938-

    2007-01-01

    Eesti elanike joogivee-uuringust, mis tehti 2004. aastal Eesti Stomatoloogia Seltsi tellimisel. Lisad: Eesti elanike joogivee fluoriidisisalduse kaart. Elanike jaotus tarbitava joogivee fluoriidisisalduse alusel maakonniti

  17. Võrumaa mitmekesisuse võlu / Ere Raag ; intervjueerinud Ene Riet

    Index Scriptorium Estoniae

    Raag, Ere

    2015-01-01

    Võrumaa Keskraamatukogu pearaamatukoguhoidja räägib, kuidas ja miks valis ta oma erialaks raamatukogunduse, kus ja kellena ta on töötanud ning mida on raamatukogundus talle andnud. Arutletakse ka raamatukogunduse ning raamatukoguhoidja tuleviku üle

  18. Preparation of Novel Hydrolyzing Urethane Modified Thiol-Ene Networks

    Science.gov (United States)

    2011-10-25

    Desmodur® 3600 were obtained from Ciba Specialty Chemicals and Bayer Material Science, respectively. Chloroform and toluene were obtained from Fischer...2,2,3,3,-tetrafluro propyl tris(2-vinyloxy) ethyl orthosilicate. Ethylene glycol vinyl ether was combined with tetraethyl orthosilicate and 2,2,3,3... propyl tris(2-vinyloxy) ethyl orthosilicate was obtained as a viscous liquid in 88% yield determined by NMR and used without further purification

  19. Läänemeri vs Nord Stream / Ene Kaups

    Index Scriptorium Estoniae

    Kaups, Ene, 1963-

    2009-01-01

    Riigikogu võttis vastu avalduse Läänemerre kavandatava gaasijuhtmega seotud keskkonnariskidest, kus avaldatakse muret, et Nord Stream AG poolt algatatud gaasijuhtme projekti rahvusvahelise keskkonnamõju hinnangutes ei ole piisavalt arvestatud kõigi seonduvate keskkonnariskidega

  20. Taimede kasvu ja biomassi jaotumise ökofüsioloogilised mehhanismid = Ecophysiological mechanisms of forest plant growth and biomass distribution : parim doktoritöö loodusteaduste valdkonnas / Angelika Portsmuth

    Index Scriptorium Estoniae

    Portsmuth, Angelika, 1977-

    2009-01-01

    Doktoritöö eesmärgiks oli selgitada lehtede ja kogu taime füsioloogilise aktiivsuse ja taimestruktuuri vaheliste seoste keskkonnapoolseid ning geneetilisi kontrollmehhanisme, uurida erinevatel integratsiooniastmetel (leht, maapealne võrse, kogu taim) ja kontsentreeruda eelkõige taimede fotosünteetilist produktiivsust määravatele taimestruktuursetele faktoritele

  1. Panel discussion: Europe, America, and the Baltics - political and economic relations

    Index Scriptorium Estoniae

    2004-01-01

    Diskussioonis USA, Euroopa ja Baltimaade suhetest osalesid USA suursaadik Eestis Joseph DeThomas, Euroopa Komisjoni delegatsiooni juht Eestis John Kjaer, Türgi suursaadik Eestis Ömer Altug, välisministeeriumi kantsler Priit Kolbre jt. Vestlusringi juhtis Karlis Streips Lätist

  2. Ene Üleoja: "Kreeki ei ületa praegu keegi" / Ene Üleoja ; intervjueerinud T[iina] M[attisen

    Index Scriptorium Estoniae

    Üleoja, Ene, 1937-

    2010-01-01

    Heliloojate Liidu ja Pirita kloostri poolt välja kuulutatud heliloominguvõistluse "Taaveti laul" tulemustest žürii liikme E. Üleojaga. Konkursi lõppkontsert toimus 10. veebr. Pirita kloostris, esines Voces Musicales Endrik Üksvärava juhatusel

  3. Tootedisaineri töö peenmehaanika ja olemise jaatus / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2011-01-01

    Tootjate ja riskikapitalistide huvist tootedisaineri teenuse vastu. Eesti disainibüroodest MaDis-Stuudio (Matti Õunapuu), Ten Twelve (asutaja: Jukka Halttunen), Keha3 (Margus Triibmann, Tarmo Luisk, Pavel Sidorenko, juht: Ville Jehe) ja Iseasi (Martin Pärn, Sven Sõrmus, Edina Dufala-Pärn, Pent Talvet, Kaspar Torn), pakutavatest teenustest ja töödest

  4. Eesti keele sõnavara afektikalduvus ja mis sellega peale hakata / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene, 1964-

    2012-01-01

    Praktilisest vajadusest väljakasvanud probleemist muuta eestikeelne sünteeskõne loomulikumaks ja emotsionaalselt usutavamaks. Artiklis keskendutakse leksikaalsele tasandile, arutletakse selle üle, millised sõnaklassid on enim emotsioonidega seotud

  5. Otsusta Eesti Tulevik / Arnold Rüütel, Ene Ergma, Juhan Parts

    Index Scriptorium Estoniae

    Rüütel, Arnold

    2003-01-01

    Ilmunud ka Valgamaalane (2003/Jun/28) lk. 2 ; Sakala (2003/Jun/27) lk. 2 ; Koit (2003/Jun/26) lk. 7 ; Maaleht (2003/Jun/26) lk. 4 ; Põhjarannik (2003/Jun/26) lk. 2 ; Severnoje Poberezhje (2003/Jun/26) lk. 2 ; Vooremaa (2003/Jun/26) lk. 1 ; Vaba Eesti Sõna (2003/Jul/2) lk. 3 ; Tribüün : Euroopa Liidu rahvahääletuse eri (2003/Aug/15) lk. 3. Vabariigi Presidendi, Riigikogu esimehe ja peaministri ühisavalduse tekst

  6. Kuressaare kultuurikeskus täitus eile leivalõhnaga / Ene Kallas

    Index Scriptorium Estoniae

    Kallas, Ene

    2009-01-01

    Kuressaare kultuurikeskuse näituse "Leib on talu peremees" avamisel viisid Eesti Põllumajandusmuuseumi töötajad läbi leivaprogrammi. Näituse koostas Mare Viiralt, kunstnikutöö tegi Maarika Tang

  7. Learning Organizations. Studiu exploratoriu asupra Consiliilor Judeţene din România

    Directory of Open Access Journals (Sweden)

    Diana GHIURA

    2012-12-01

    Full Text Available This article is the result of an ample study centered on the concept of learning organizations, more precisely on the degree in which Romanian County Councils are learning organizations. In order to analyze this, a research instrument has been sent to every County Council. This tool has been developed by three Harvard professors: David A. Garvin, Amy C. Edmondson and Francesca Gino who also published, in 2008, an article in Harvard Business Review ‘Is Yours A Learning Organization?’. Their article is fundamental for this study. Approximately 26 out of 41 County Councils participated to the study and the findings are summarized in this article. The results were really interesting and according to them, Romanian County Councils are learning organizations only in terms of leadership that encourages learning. Regarding the other two blocks – learning environment and learning processes, the findings revealed that the County Councils act like learning organizations in a very small degree. As a consequence, the organizations that participated to the study still have many things to improve in order to become learning organizations.

  8. Riigipeade kokad - Chefs des Chefs / Sirkka Ruottinen, Indrek Kivisalu ; interv. Ene Ojaveski

    Index Scriptorium Estoniae

    Ruottinen, Sirkka

    2006-01-01

    Soome presidendi Tarja Haloneni ja Eesti presidendi Arnold Rüütli peakokad räägivad oma karjäärist presidendi peakoka ametini, kirjeldavad tavalist tööpäeva ja töökeskkonda presidendi köögis, iseloomustavad Soome ja Eesti toidukultuuri ning meenutavad huvitavaid seiku oma ametiajast. Vt. samas: Sirkka Ruottinen vastab küsimustele, mis puudutavad Riigipeade Peakokkade Klubi (Club des Chefs des Chefs) tegevust

  9. Emotsioonid eesti keele käeväljendites / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene, 1964-

    2010-01-01

    Analüüsitakse eesti keele kõnelejate konventsionaalseid teadmisi ja ettekujutusi suhtlusprotsessist, uurides lähemalt leksikaalseid väljendeid, mille üheks komponendiks on viide käele (või selle osale)

  10. Tööjuhendid algklassi tööõpetuse tundides / Ene Lind

    Index Scriptorium Estoniae

    Lind, Ene

    2001-01-01

    Tekstiga tööst tööõpetuse tunnis, kirjalikust ja suulisest juhendamisest. Tallinna Pedagoogikaülikooli üliõpilaste poolt läbi viidud küsitlusest, milles osalesid 22 klassiõpetajat Tallinnast ja 15 mujalt vabariigist. Kõik pedagoogid andsid oma klassis ka tööõpetuse või käsitöö tunde. Küsitlusega selgitati, milline on tööjuhendite abil korraldatava iseseisva individuaalse töö osatähtsus noorema kooliastme tööõpetuse ja eri õppeainete tundides

  11. How newness enters a country : reception of the "postcolonial" in Estonia / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet, 1968-

    2006-01-01

    Postkolonialistliku tõlkekirjanduse retseptsiooni Eestis vaadeldakse kolme romaani põhjal: Arundhati Roy "Väikeste Asjade Jumal" (eesti k. 1997 ja 2004), Salman Rushdie "Mauri viimane ohe" (eesti k. 2001 ja 2008), Ben Okri "Näljutatud tee" (eesti k. 1998)

  12. Courants du Monde'i programmi toel Prantsusmaal / Asko Tamme ; intervjueerinud Ene Riet

    Index Scriptorium Estoniae

    Tamme, Asko

    2010-01-01

    Intervjuu Tartu Linnaraamatukogu direktori Asko Tammega, kes käis tutvumas Prantsusmaa raamatukogudega, sh Pompidou keskuse raamatukoguga, Rennes'i keskraamatukoguga ning Raamatu ja Lugemise Bretagne'i keskusega (Livre et Lecture en Bretagne)

  13. Maakondliku Liivide etluskonkursi võitis gümnasist Marian Heinat / Ene Kallas

    Index Scriptorium Estoniae

    Kallas, Ene

    2008-01-01

    Maakondliku Juhan ja Jakob Liivi etluskonkursi žüriisse kuulusid Ott Aardam, Käthe Pihlak, Piret Rauk, Vaido Luks ja Marili Pärtel. Grand prix' võitis Marian Heimat, laureaatideks tulid Liisa Saaremäel, Maria Pihlak ja Laura Oolup. Eripreemiad said Marii Metsmaa, Ermo Loik, Sander Aavik, Kaimar Nuut ja Priidu Aardam

  14. Tammsaare, Kangro ja Vanapagan / Ilse Lehiste ; inglise k. tlk. Ene-Reet Soovik

    Index Scriptorium Estoniae

    Lehiste, Ilse, 1922-2010

    2000-01-01

    Orig.: Tammsaare, Kangro and the Devil. Varem ilmunud: Baltic Literature and Linguistics. Ohio : Association for the Advancement of Baltic Studies, 1973. A. H. Tammsaare romaanist "Põrgupõhja uus Vanapagan" (1939) ning Bernard Kangro romaanist "Taeva võtmed" (1956)

  15. Õpetaja haridus, kooliharidus ja ühiskond / Ene-Silvia Sarv

    Index Scriptorium Estoniae

    Sarv, Ene-Silvia, 1945-

    1999-01-01

    Rahvusvahelise Haridusentsüklopeedia tekstist ja Eesti õpetajakoolituse uuendamise kavadest inspireeritud mõtisklus. Teoreetilised teadmised, võimed, eeldused, mida peetakse õpetajale vajalikuks, on seotud haridusele omastatavate eesmärkidega

  16. Leila Pärtelpoeg / Leila Pärtelpoeg ; interv. Ene Ammer

    Index Scriptorium Estoniae

    Pärtelpoeg, Leila, 1927-

    1998-01-01

    Leila pärtelpoeg oma elust, arengust ja loomingust. Õpingutest Tallinna Riiklikus Tarbekunstiinstituudis, õppejõududest. Stazheerimisest Ermitaazhis NSVL mööblitundja Tatjana Mihhailovna Sokolova juures

  17. Solvent Effects in Asymmetric Hetero Diels-Alder and Ene Reactions

    DEFF Research Database (Denmark)

    Johannsen, Mogens; Jørgensen, Karl Anker

    1996-01-01

    The use of polar solvents such as nitromethane or 2-nitropropane leads to a significant improvement of the catalytic properties of a cationic copper-Lewis acid in the hetero Diels-Alder reaction of alkyl glyoxylates with dienes; The scope of a newly developed copper(II)-bisoxazoline catalyst...... for the hetero Diels-Alder reaction is demonstrated by the reaction of different dienes with alkyl glyoxylates in nitroalkane solvents with the formation of the hetero Diels-Alder adduct in high enantiomeric excess as the major product. The synthetic application of the reaction is exemplified by an improved...

  18. Me suudame ajaga kaasas käia / interv. Ene Riet

    Index Scriptorium Estoniae

    2003-01-01

    Eesti raamatukoguhoidjate VIII kongressi (9.-10. juuni 2002) delegaatitelt küsiti arvamust Eesti raamatukogunduse kohta, vastasid: Kalli Kuhi, Sirje Okapuu, Toomas Liivamägi, Sirje Lauring-Vaska, Helve Sreiberg, Irina Kruusla, Ädu Neemre, Tiit Margna, Valentina Brovina, Asko Tamme, Meeli Veskus

  19. Kütiorus on kõrvuti pronksiaeg ja postmodernism / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Külaskäik Kütioru Avatud Ateljeesse. Peeter ja Leelo Lauritsa tegemistest ja plaanidest seoses ateljeega. Valminud on ateljeemaja ümberehitamise makett. Ehitusmaterjaliks savi. Nõustavad Tartu ökoinsenerid. Sügisel 1999 viibisid Kütiorus Vogue'i ajakirjanikud ja Londoni fotograaf Zanna, et teha Casa Vogue'ile illustreeritud Kütioru Avatud Ateljeed tutvustav lugu. 5 värvilist illustratsiooni

  20. Synthesis and In Vitro Antiproliferative Activity of Novel Androst-5-ene Triazolyl and Tetrazolyl Derivatives

    Directory of Open Access Journals (Sweden)

    János Wölfling

    2011-06-01

    Full Text Available A straightforward and reliable method for the regioselective synthesis of steroidal 1,4-disubstituted triazoles and 1,5-disubstituted tetrazoles via copper(I-catalyzed cycloadditions is reported. Heterocycle moieties were efficiently introduced onto the starting azide compound 3β-acetoxy-16β-azidomethylandrost-5-en-17β-ol through use of the “click” chemistry approach. The antiproliferative activities of the newly-synthesized triazoles were determined in vitro on three human gynecological cell lines (HeLa, MCF7 and A2780 using the microculture tetrazolium assay.

  1. Incorporating allylated lignin-derivatives in thiol-ene gel-polymer electrolytes.

    Science.gov (United States)

    Baroncini, Elyse A; Stanzione, Joseph F

    2018-07-01

    Growing environmental and economic concerns as well as the uncertainty that accompanies finite petrochemical resources contributes to the increase in research and development of bio-based, renewable polymers. Concurrently, industrial and consumer demand for smaller, safer, and more flexible technologies motivates a global research effort to improve electrolytic polymer separators in lithium-ion batteries. To incorporate the aromatic structural advantages of lignin, a highly abundant and renewable resource, into gel-polymer electrolytes, lignin-derived molecules, vanillyl alcohol and gastrodigenin are functionalized and UV-polymerized with multi-functional thiol monomers. The resulting thin, flexible, polymer films possess glass transition temperatures ranging from -42.1°C to 0.3°C and storage moduli at 25°C ranging from 1.90MPa to 10.08MPa. The crosslinked polymer films swollen with electrolyte solution impart conductivities in the range of 7.04×10 -7 to 102.73×10 -7 Scm -1 . Thiol molecular weight has the most impact on the thermo-mechanical properties of the resulting films while polymer crosslink density has the largest effect on conductivity. The conducting abilities of the bio-based gel-polymer electrolytes in this study prove the viability of lignin-derived feedstock for use in lithium-ion battery applications and reveal structurally and thermally desirable traits for future work. Copyright © 2018 Elsevier B.V. All rights reserved.

  2. Tre tilfaelde af visceral leishmaniasis: det ene hos en HIV-positiv mand

    DEFF Research Database (Denmark)

    Balslev, U; Jonsbo, F; Junge, Jette

    1991-01-01

    Three cases of visceral leishmaniasis (kala-azar) are presented. One of these was in a 43-year-old patient with AIDS who was infected in Southern Spain. Another was in a man aged 25 years infected in West Africa. These cases are the first two adults to be reported in Denmark. The third case...

  3. Mari e-raamatukogu / Tatjana Verina ; vene keelest tõlkinud Ene Riet

    Index Scriptorium Estoniae

    Verina, Tatjana

    2011-01-01

    Mari e-raamatukogu loomise aluseks on Mari-Eli Vabariigi etnokultuuriliste ja rahvusvaheliste suhete arendamise projekt, hetkel on elektroonilises raamatukogus 52 täistekstilist teavikut Tšavaini nimelise Mari Rahvusraamatukogu haruldaste raamatute kogust

  4. Terves kehas terve vaim - a sound mind in a sound body / Ene Kelder

    Index Scriptorium Estoniae

    Kelder, Ene

    2012-01-01

    Pühajärve Haridusseltsi täiskasvanutele suunatud projektist, mille eesmärgiks oli suurendada täiskasvanud õppijate hulka piirkonnas ning praktiseerida aktiivset eluhoiakut ja tervislikke eluviise

  5. Kas üksiku ülikooli või Eesti huvid? / Ene Grauberg, Peeter Kreitzberg

    Index Scriptorium Estoniae

    Grauberg, Ene, 1944-

    2006-01-01

    Autorid peavad meie kõrghariduse ja teaduse arengu probleemiks, et kogu kõrghariduse ja teaduse valdkonda juhib faktiliselt Tartu Ülikool. Nad selgitavad oma avalikku kirja haridus- ja teadusminister Mailis Repsile 29. septembri Õpetajate Lehes ning esitavad vastuväiteid Volli Kalmu seisukohtadele 31. oktoobri Eesti Päevalehe artiklis

  6. Punane moon või kaine mõistus / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2001-01-01

    Nukuteatri uue hoone sisekujunduse võistluse I ja II koha töödest. I koha töö autorid Raivo Kotov ja Andrus Kõresaar, II koha töö autorid Ülar Mark, Liina Link, stilist Ain Nurmela ja arvutigraafik Tanel Viks büroost Mark & Tamm Arhitektid

  7. Arupärimine rahandusministrile eurokalkulaatoritest / Jürgen Ligi, Ene Ergma, Helle Kalda...[jt.

    Index Scriptorium Estoniae

    2011-01-01

    Riigikogu liikmete Helle Kalda, Toomas Vareki, Aivar Riisalu, Lauri Laasi, Mailis Repsi, Enn Eesmaa, Kalle Laaneti, Eldar Efendijevi, Nelli Privalova, Vladimir Velmani, Olga Sõtniku, Kalev Kallo, Toivo Tootseni, Arvo Sarapuu, Nikolai Põdramägi Evelyn Sepa, Ain Seppiku ja Valeri Korbi poolt 17. novembril esitatud arupärimine

  8. Kas nii nagu ikka? : Eesti Sisearhitektide Liidu 2010. aasta preemiad / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2011-01-01

    Konkursist "Eesti interjöörid ja mööblidisain 2010". Söögikoha interjööri preemia: kohvik Supelsaksad Pärnus (Ruth ja Anna Huimerind), ühiskondliku interjööri preemia: ADM Interactive'i bürooruumid Tallinnas (Tomomi Hayashi, Ahti Grünberg, Kerli Valk), ajaloolise interjööri preemia: Kihnu muuseum (Malle Jürgenson, Tea Tammelaan, Krista Lepland, Jaak Huimerind, Indrek Laos), näituse- ja installatsiooni kujunduse preemia: rändnäitus "Eesti kirjanik karikatuuris" (Janno Siimar, Kaarel Vahtramäe, Mart Lankots, Liina Jakobson), tudengipreemia - Aet Tera. 24 nominenti loetletud

  9. Artur Lemba - tunglakandja : Ühe suurmehe metaelulugu / Ene Metsjärv ; intervjueerinud Marju Riisikamp

    Index Scriptorium Estoniae

    Metsjärv, Ene, 1943-

    2014-01-01

    Pianist, helilooja ja pedagoog Artur Lemba elust ja loometööst. A. Lemba õpilaste Veera Lensini, Salme Lohuaru (kuni 1950 Andre), Valentine Riivese, Tiiu Targamaa, Villem Reimanni ja Elsa Avessoni ülestähendusi oma õpetajast

  10. Muudatused sisemajanduse koguprodukti arvestustes = Changes in the methodology of macroeconomic statistics / Ene Kaldma

    Index Scriptorium Estoniae

    Kaldma, Ene

    2004-01-01

    2004. aastal tehtud muudatused makromajandusstatistika metoodikas tõid kaasa 1993.-2003. aasta sisemajanduse koguprodukti (SKP) ja selle komponentide suuruse korrigeerimise. Tabel: Sisemajanduse koguprodukt turuhindades kvartalite kaupa enne ja pärast metoodika muutumist, 1993-2003

  11. Are all Building Information Models (BIM) the same?; Het ene BIM is het andere niet

    Energy Technology Data Exchange (ETDEWEB)

    Bouwman, J.W. [VolkerWessels, Rotterdam (Netherlands); Kuijer, H.J. [DHV, Amersfoort (Netherlands)

    2011-04-15

    Building Brains has been set up by TNO as a cooperative and started September 21, 2009. The aim of the project was to answer the question how the energy consumption in the Netherlands can be reduced by 50% up to 2030 or how the built environment can be made energy-neutral. This issue of the magazine is dedicated to Building Brains project. BIM (Building Information Modelling) is one of the major buzzwords in the building industry today. However, not every BIM in the market is the same, nor have they the same intentions, nor have they the same functionality. In this article the authors argument the reasons behind the structure of BIM data as used by the project Building Brains as well as its use in the newly developed building process. In the second part of this article the authors demonstrate the advantages of this structure by means of an example in the design process, where, thanks to a BIIM and a suitable library, the data always represents a 100% finished building (however in the early design stage the largest part of the data will be 'in progress' as towards the end of the design the largest part of the data will be 'final') [Dutch] Building Brains is een door TNO opgezet samenwerkingsproject dat op 21 september 2009 van start ging. Het doel van het project is antwoord te geven op de vraag hoe tot 2030 het energiegebruik in Nederland kan worden gehalveerd of hoe de gebouwde omgeving energieneutraal kan worden gemaakt. Deze aflevering van het tijdschrift TVVL is vrijwel geheel gewijd aan het Building Brains project. Het gebouw was een van de onderwerpen in Building Brains. De onderzoeksdoelstelling bij dit onderwerp luidde: 'Onderzoek wat nodig is om te komen tot een breed toepasbaar, bestendig recept met ingredienten en gerei om in de nabije toekomst gebouwen aantoonbaar duurzaam te maken'. Een randvoorwaarde was: 'Hoe en in welke vorm is BIM (Bouwwerk Informatie Model) in dit recept inzetbaar'. Dit artikel gaat in op de overwegingen die hebben geleid tot de (verdere) ontwikkeling van BIM in relatie tot duurzaamheid.

  12. Emotsioonisõnad töises keskkonnas - millest kõnelevad loetelukatsete tulemused? / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene

    2007-01-01

    Emotsioonisõnade esiletulekut tööl ja mujal võrreldakse 2001. aastal läbi viidud loetelukatsetes, tulemuste semantilise analüüsi põhjal tehakse järeldused koha mõju üle emotsioonisõnavarale

  13. Amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid

    Czech Academy of Sciences Publication Activity Database

    Özdemir, Zülal; Bildziukevich, Uladzimir; Šaman, David; Havlíček, Libor; Rárová, L.; Navrátilová, L.; Wimmer, Zdeněk

    2017-01-01

    Roč. 128, DEC (2017), s. 58-67 ISSN 0039-128X R&D Projects: GA MŠk LD15012 Institutional support: RVO:61389030 ; RVO:61388963 Keywords : Amphiphile * Antimicrobial activity * Cytotoxicity * Diamine * Polyamine * Steroid Subject RIV: CC - Organic Chemistry; CC - Organic Chemistry (UOCHB-X) OBOR OECD: Organic chemistry Impact factor: 2.282, year: 2016

  14. Limitations of the Neurological Evolutional Exam (ENE) as a motor assessment for first graders.

    Science.gov (United States)

    Caçola, Priscila M; Bobbio, Tatiana G; Arias, Amabile V; Gonçalves, Vanda G; Gabbard, Carl

    2010-01-01

    many clinicians and researchers in Brazil consider the Neurological Developmental Exam (NDE), a valid and reliable assessment for Brazilian school-aged children. However, since its inception, several tests have emerged that, according to some researchers, provide more in-depth evaluation of motor ability and go beyond the detection of general motor status (soft neurological signs). to highlight the limitations of the NDE as a motor skill assessment for first graders. thirty-five children were compared on seven selected items of the NDE, seven of the Bruininks-Oseretsky Test (BOT), and seven of the Visual-Motor Integration test (VMI). Participants received a "pass" or "fail" score for each item, as prescribed by the respective test manual. chi-square and ANOVA results indicated that the vast majority of children (74%) passed the NDE items, whereas values for the other tests were 29% (BOT) and 20% (VMI). Analysis of specific categories (e.g. visual, fine, and gross motor coordination) revealed a similar outcome. our data suggest that while the NDE may be a valid and reliable test for the detection of general motor status, its use as a diagnostic/remedial tool for identifying motor ability is questionable. One of our recommendations is the consideration of a revised NDE in light of the current needs of clinicians and researchers.

  15. Lean versus Quick Response Manufacturing og andre koncepter - er Lean den eneste ene?

    DEFF Research Database (Denmark)

    Michelsen, Aage U

    2005-01-01

    Begrebet Lean har gennem de senere år vundet en enorm udbredelse. Antallet af publikationer om Lean har været eksplosivt stigende, og mange virksomheder har gennemført eller gennemfører Lean-projekter. Er Lean et nyt koncept? Er Lean den eneste løsning? Kan Lean kombineres med tankegange og princ...... løsning af en anden produktionsopgave. I fjerde afsnit skitseres kort relationerne mellem Lean og to andre begreber, Six Sigma og TPM, der begge har samme mål som Lean, men forskellige udgangspunkter og forskellige indfaldsvinkler....

  16. Prügilill, vana hõng ja minimalism / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Kahest äärmusest praeguses aiakujunduses: minimalismist ja vanahõngulisest, hästi organiseeritud segadusest. Erinevatest materjalidest terrassist, "woodland'ist", moesolevatest prügitaimedest. Trendinäiteks Saksa saatkonna haljasalast Tallinnas (arhitekt R. Herms, teostus Ü. ja U. Grishakov). Soovitusi maastikuarhitekt Ü. Grishakovilt

  17. Juhatus ja raamatupidaja jagavad vastutust. [1.-2. osa] / Ene Ahas, Alo Pormeister

    Index Scriptorium Estoniae

    Ahas, Ene, 1973-

    2017-01-01

    Varalise vastutuse kokkuleppest, raamatupidaja ja juhatuse vastutusest. Tööõiguslikust vastutusest töölepingu seaduse alusel ja kahju hüvitamisest tööandjale. Lepingulisest ja lepinguvälisest vastutusest. Sisaldab asjakohast kohtupraktikat

  18. The Secret of Bosnia Sceptre by Enes Ratkušić

    OpenAIRE

    Hasanagić, Senad

    2014-01-01

    Bosnia plays like thrilling dark forces which broke the resistance of the belief that they can only now trying to snatch the sceptre but they are faced with the power of the royals to the country. They believe that to protect the Did’s Sceptre is a holy mission and the sceptre will be delivered to the Saver who will come when the evil and cruelty rule the world

  19. Vaesus ja ebavõrdsus = Poverty and inequality / Mari Kreitzberg, Ene-Margit Tiit

    Index Scriptorium Estoniae

    Kreitzberg, Mari

    2004-01-01

    Vaesuse ja ühiskonna sotsiaalsest sidususest, vaesuse määratlemisest, subjektiivsest vaesusest, sissetuleku- ja kuluvaesusest, vaesuspiirist, absoluutsest ning suhtelisest vaesusest. Diagrammid. Tabelid. Graafikud

  20. 78 FR 717 - ENE (Environment Northeast); Greater Boston Real Estate Board; National Consumer Law Center...

    Science.gov (United States)

    2013-01-04

    ... Customer Coalition; v. Bangor Hydro-Electric Company; Central Maine Power Company; New England Power... United Illuminating Company; Unitil Energy Systems, Inc.; Fitchburg Gas and Electric Light Company... (Complainants) filed a formal complaint against Bangor Hydro-Electric Company; Central Maine Power Company; New...

  1. Interviewer behaviour during oral proficiency interviews : a gender perspective / Edith Reemann, Ene Alas, Suliko Liiv

    Index Scriptorium Estoniae

    Reemann, Edith

    2013-01-01

    Analüüsitakse intervjueerija käitumise soolisi iseärasusi inglise keele riigieksami suulise keelepädevustesti läbiviimisel, kas on olemas ühele või teisele sugupoolele omaseid käitumismalle ning kas need võiksid mõjutada intervjueeritavat oma oskuste demonstreerimisel

  2. Microcellular open porous polyester membranes from thiol-ene polymerisations of high internal phase emulsions

    Czech Academy of Sciences Publication Activity Database

    Sušec, M.; Paljevac, M.; Kotek, Jiří; Krajnc, P.

    2016-01-01

    Roč. 19, č. 6 (2016), s. 577-583 ISSN 1385-772X R&D Projects: GA MŠk(CZ) LO1507 Institutional support: RVO:61389013 Keywords : polymer membranes * mechanical properties * polyHIPE Subject RIV: CD - Macromolecular Chemistry Impact factor: 1.139, year: 2016

  3. Vene kinopravdast sai prantsuse cinema-verite / Ronald Bergan ; tõlk. Ene Jürna

    Index Scriptorium Estoniae

    Bergan, Ronald

    2004-01-01

    FIPRESCI asepresident meenutab 18. veebruaril 2004.a. surnud prantsuse dokumentalistika suurkuju Jean Rouchi (sünd. 31.05.1917). Lisatud Jaan Ruusi kommentaar Rouchi sidemetest Eesti kineastide Mark Soosaare ja Vladimir Karassev-Orgussaarega

  4. Mida teevad mõtted, kui nad "mõlguvad"? / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene, 1964-

    2013-01-01

    Kognitiivsest semantikast, eriti kehapõhisuse teooriast lähtudes, uuritakse, milline kehaline kogemus on motiveerinud sõna "mõlkuma" kasutuselevõtmist perioodilisi mõtteprotsesse tähistava verbina

  5. Austraalia ilusaim rannikutee sõjaohvrite mälestuseks / Eneli Ivask

    Index Scriptorium Estoniae

    Ivask, Eneli

    2006-01-01

    Vt. ka Delovõje Vedomosti : Vkuss Zhizni 13. sept., lk. 4-5. Austraalia lõunarannikul, mitte kaugel Melbourneist on maailma kauneimaks peetav 400 km pikkune hingematvalt lummavate ja erinäoliste vaadetega rannikutee - Great Ocean Road

  6. Kelle emotsioonile anda teksti ette lugedes hääl? Vaatlus mitmest perspektiivist / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene, 1964-

    2014-01-01

    Püütakse esile tuua, milliste inimloomusest tulenevate tõsiasjadega peab arvestama, kui hakata sünteeskõnele emotsioone matkivat prosoodiat lisama. Koondatud on lähenemised erinevatest teadusharudest

  7. Lendab nagu kotkas üle maailmas kogutud tarkuse / Richard Aroksaar ; intervjueerinud Ene Riet

    Index Scriptorium Estoniae

    Aroksaar, Richard

    2014-01-01

    Intervjuu eestlase Richard Aroksaarega, kes õppinud psühholoogiat ja raamatukogundust, töötab USA Rahvusparkide Ühenduse raamatukogus (National Park Service Library, NPS) süsteemi raamatukoguhoidja ja administraatorina

  8. Novel approaches for using dehydrogenases and ene-reductases for organic synthesis

    NARCIS (Netherlands)

    Gargiulo, S.

    2015-01-01

    Oxidation of alcohols is a reaction of major interest for organic chemistry. However, the most common chemical routes developed so far involve the use of toxic or hazardous reagents or catalysts that often lack good chemoselectivity. In this respect, alcohol dehydrogenases (ADHs) represent a very

  9. Takova zhizn, ili nash tshelovek v Pompidu / Ene Rämmeld ; interv. Boris Tuch

    Index Scriptorium Estoniae

    Rämmeld, Ene, 1947-

    2004-01-01

    Pariisis elav näitlejanna esitles oma autobiograafilist raamatut "C'est la vie. Elu on selline", milles juttu kolmest kunstnikust : L. Laiusest, E. Hermakülast ja V.G. Karassev-Orgussaarest - kuidas nad kõik mõjutasid näitlejanna arengut. Ka oma elust ja elufilosoofiast praegu

  10. Identification of fungal ene-reductase activity by means of a functional screening.

    Science.gov (United States)

    Romagnolo, Alice; Spina, Federica; Brenna, Elisabetta; Crotti, Michele; Parmeggiani, Fabio; Varese, Giovanna Cristina

    2015-06-01

    Bioeconomy stresses the need of green processes promoting the development of new methods for biocatalyzed alkene reductions. A functional screening of 28 fungi belonging to Ascomycota, Basidiomycota, and Zygomycota isolated from different habitats was performed to analyze their capability to reduce C=C double bonds towards three substrates (cyclohexenone, α-methylnitrostyrene, and α-methylcinnamaldehyde) with different electron-withdrawing groups, i.e., ketone, nitro, and aldehyde, respectively. Almost all the fungi showed this reducing activity. Noteworthy Gliomastix masseei, Mucor circinelloides, and Mucor plumbeus resulted versatile and effective, being able to reduce all the model substrates quickly and with high yields. Copyright © 2015 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

  11. Animafilm mõistmisest ja tolerantsist jõuab Kuressaarde / Ene Kallas

    Index Scriptorium Estoniae

    Kallas, Ene

    2008-01-01

    Kuressaarde jõuab koos ajaloolase David Vseviovi sissejuhatava loenguga animadraama "Persepolis" : režissöörid Marjane Satrapi (oma koomiksi järgi) ja Vincent Paronnaud : Prantsusmaa - Ameerika Ühendriigid - Iraan 2007

  12. Milleks põllumajandusmaastiku elurikkus? / Eneli Viik, Iiri Raa, Ere Ploomipuu, Katrin Vask

    Index Scriptorium Estoniae

    2012-01-01

    Elurikkus on meie maakeral leiduva kogu elusa looduse mitmekesisus, mida võib eristada kolmel tasandil: geneetiline tasand, liikide tasand, koosluste mitmekesisuse tasand. Kuidas säilitada elurikkust põllumajandusmaastikul

  13. Roll-to-plate fabrication of microfluidic devices with rheology-modified thiol-ene resins

    DEFF Research Database (Denmark)

    Senkbeil, Silja; Aho, Johanna; Yde, Leif

    2016-01-01

    of 2:1 and a maximal channel depth of 90 μm as well as the sealing of the finished devices with patterning and sealing speeds of up to 19 m min-1. By adding fumed silica nanoparticles to the uncured resins, it was possible to alter the rheological behavior of the resin system to fabricate shallow...

  14. Collective memory and the politics of experience in Estonian post-Soviet life stories / Ene Kõresaar

    Index Scriptorium Estoniae

    Kõresaar, Ene, 1971-

    2005-01-01

    Elulugude põimumine kultuuritraditsioonide ja suulise traditsiooniga ning nende jutustamine kui poliitilise ajaloo väljendusvorm. Kollektiivse mälu ja poliitika vahelistest seostest kahe Eesti Kultuuriloolisele Arhiivile saadetud Eesti nõukogude aega kajastava eluloo alusel

  15. Photolithographic fabrication of solid–liquid core waveguides by thiol-ene chemistry

    DEFF Research Database (Denmark)

    Sagar, Kaushal Shashikant; Gopalakrishnan, Nimi; Christiansen, Mads Brøkner

    2011-01-01

    on the type and grade of surface chemistry imparted to the large nanoporous area depending upon the application. The fabrication does not need demanding chemical reaction conditions. Thus, it can be readily used on a standard silicon lithography bench. The propagation loss values reported in this work...

  16. Dollar$ & $en$e. Part IV: Measuring the value of people, structural, and customer capital.

    Science.gov (United States)

    Wilkinson, I

    2001-01-01

    In Part I of this series, I introduced the concept of memes (1). Memes are ideas or concepts, the information world equivalent of genes. The goal of this series of articles is to infect you with my memes, so that you will assimilate, translate, and express them. We discovered that no matter what our area of expertise or "-ology," we all are in the information business. Our goal is to be in the wisdom business. We saw that when we convert raw data into wisdom we are moving along a value chain. Each step in the chain adds a different amount of value to the final product: timely, relevant, accurate, and precise knowledge which can then be applied to create the ultimate product in the value chain: wisdom. In Part II of this series, I infected you with a set of memes for measuring the cost of adding value (2). In Part III of this series, I infected you with a new set of memes for measuring the added value of knowledge, i.e., intellectual capital (3). In Part IV of this series, I will infect you with memes for measuring the value of people, structural, and customer capital.

  17. Developing interviewer proficiency : a self-perception survey / Riin Kont-Kontson, Ene Alas, Suliko Liiv

    Index Scriptorium Estoniae

    Kont-Kontson, Riin

    2013-01-01

    Inglise keele õpetajate hulgas läbi viidud uurimusest, mis näitas, et intervjueerijate arusaam oma kutsestandardist varieerub märkimisväärselt. Probleemide lahendamiseks esitatakse mitmeid koolitusstrateegiaid

  18. Diallyl 5-[(4-hexyl-oxyphen-yl)imino-meth-yl]-m-phenyl-ene dicarbonate.

    Science.gov (United States)

    Herrera-González, Ana María; López-Velázquez, Delia; Bernès, Sylvain

    2009-10-23

    The title mol-ecule, C(27)H(31)NO(7), an imine derivative bearing both carbonate and allyl functionalities, was synthesized in the hope of obtaining a mesogenic polymerizable material. The allyl-carbonate arms are fully disordered over two sets of sites, reflecting a large degree of rotational freedom about σ bonds [occupancies: 0.665 (9)/0.335 (9) for one substituent, 0.564 (9)/0.436 (9) for the other]. In contrast, the hexyl chain is ordered, and presents the common all-trans extended conformation. The benzene rings connected via the imine group make a dihedral angle of 9.64 (11)°. In the crystal, the Y-shaped mol-ecules are weakly associated into centrosymmetric dimers through pairs of C-H⋯O(hex-yl) contacts. The resulting layers of dimers, approximately parallel to (25), are closely packed in the crystal, allowing π⋯π inter-actions between benzene rings of neighboring layers: the separation between the centroid of the benzene ring substituted by allyl-carbonate and the centroid of the benzene ring bearing the hex-yloxy group in the adjacent layer is 3.895 (1) Å.

  19. Kaj napravi manj izobražene odrasle drugačne?

    Directory of Open Access Journals (Sweden)

    Dušana Findeisen

    1997-12-01

    Full Text Available Avtorica v tem prispevku obravnava vprašanje: kako se učijo manj izobraženi odrasli. V zvezi s tem se ustavi tudi pri motivaciji za izobraževanje pri takšnih odraslih učencih in ugotavlja, da imajo le življenjske potrebe, ne pa tudi izobraževalnih. Pri tem uporabljajo tudi posebne načine učenja. Vse to narekuje mentorju drugačno programiranje in izpeljavo izobraževalnega programa. Vprašanje, ki se mu Dušana Findeisen najbolj posveti, je vprašanje mentorjevega diskurza, ki mora biti čim bolj podobno diskurzu, ki ponazarja delo. Mentorjeva govorica ne sme biti formalizirana in do kraja strukturirana. Mentor naj jo takoj oblikuje. Uporablja naj dosti parafraz. Njegova misel “Se mora iskati”. Svoja spoznanja avtorica opira na izkušnje pridobljene v jezikovnih tečajih, po programih, ki temeljijo na analiziranih govornih in drugih potrebah skupine, to je programih, namenjenih skupinam natakarjev in sprevodnikov na vlakih intercity.

  20. Igal mõisal on oma lugu / Mari-Ann Remmel

    Index Scriptorium Estoniae

    Remmel, Mari-Ann

    2008-01-01

    Kirjastuselt "Tänapäev" ilmus raamat "Mõisalegendid. Harjumaa", koostaja Mari-Ann Remmel, kujundaja Angelika Schneider. Kogumik sisaldab ka ajaloolist ning genealoogilist teavet mõisahoonete ning -omanike kohta

  1. Stiilne avarus / Aita Kivi

    Index Scriptorium Estoniae

    Kivi, Aita, 1954-

    2004-01-01

    Angelika ja Meelis Maalmanni perekonna korter (93 mø) Rannamõisa teel asuvas ridaelamus. Uue plaanilahenduse ja sisekujunduse autor Aet Piel. Ill.: 8 vaadet, korteri plaan enne ja nüüd. A. ja M. Maalmanni kommentaarid

  2. Kadrioru loss / Kadi Polli

    Index Scriptorium Estoniae

    Polli, Kadi, 1973-

    2001-01-01

    Londonis tegutsenud šveitsi maalikunstnikust Angelika Kauffmannist (1741-1807), tema loomingust, väliskunstimuuseumis olevatest maalidest "Ilu, juhitud Mõistlikkusest, tõrjub meelepahaga tagasi Meeletuse ahvatlusi" ja "Ilu, juhitud Mõistlikkusest, pärjatud Täiuslikkusest".

  3. Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene (TPX with cRGD pentapeptide

    Directory of Open Access Journals (Sweden)

    Lena Möller

    2013-02-01

    Full Text Available Covalent multistep coating of poly(methylpentene, the membrane material in lung ventilators, by using a copper-free “click” approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.

  4. Ene News April 2003 - Information on energy research (German version); ENET News, April 2003, Nr. 54 deutsch

    Energy Technology Data Exchange (ETDEWEB)

    Wellstein, J.

    2003-07-01

    The April 2003 issue of ENET News, a magazine on energy research in Switzerland published three times a year, covers the topics of energy use in industry, the export of sustainable energy technologies and reviews the Swiss Research Concept for the period 2004 - 2007. Further articles discuss technology transfer from research institutes to industry, technology monitoring, new photovoltaic technologies, new techniques for the recycling of metal, wood energy and the energetic use of biogas from wastewater treatment plants and of drainage water from alpine tunnels. Further, small hydro schemes are described, the hydronics of small heat pump systems are discussed and the efficient use of fossil fuels in combined heat and power / heat pump combinations is examined. Other topics covered include low-energy consumption building, nuclear reactor safety and biomass-based fuels.

  5. Poly[[μ-aqua-tetraaquabis(μ-2-hydroxy-4-oxocyclobut-1-ene-1,3-diolatostrontium] hemihydrate

    Directory of Open Access Journals (Sweden)

    Amira Bouhali

    2011-08-01

    Full Text Available In the title coordination polymer, {[Sr(C4HO42(H2O5]·0.5H2O}n, the Sr2+ ion is coordinated by three monodentate hydrogensquarate (hsq anions and six aqua ligands in a distorted SrO9 monocapped square-antiprismatic geometry. The hsq anions and water molecules bridge the metal ions into infinite sheets lying parallel to (100. The O atom of the uncoordinated water molecule lies on a crystallographic twofold axis. The packing is stabilized by numerous O—H...O hydrogen bonds.

  6. Perspectives on the emblems of the nation in contemporary Estonian and Anglo-Welsh poetry / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet, 1968-

    2000-01-01

    Kaasaegse eesti luule ja Walesi ingliskeelse luule võrdlemiseks on kasutatud uusi antoloogiaid: Eesti luule antoloogia II (koost. Raivo Kuusk, 1998), Twentieth-century anglo-welsh poetry (ed. Dannie Abse, 1997)

  7. Eugene O'Neill "Pikk päevatee kaob öösse" / Ellu Eik ; interv. Ene Paaver

    Index Scriptorium Estoniae

    Eik, Ellu

    2008-01-01

    Seoses Eesti Draamateatri suvelavastusega "Pikk päevatee kaob öösse" (autor Eugene O'Neill ja lavastaja Merle Karusoo) räägib Lääne-Tallinna Keskhaigla Sõltuvusravikeskuse psühhiaater Ellu Eik sõltuvuse tagamaadest ja mõjudest

  8. Tänavune provintsiteatripäev soovis Koidulaulikule õnne sünnipäevaks / Ene Kallas

    Index Scriptorium Estoniae

    Kallas, Ene

    2008-01-01

    Muljeid Saaremaa 11. provintsiteatripäevalt, mis pühendatud Lydia Koidula 165. sünniaastapäevale. Kuus näiteseltskonda esitas Koidula näidendid "Kosjakased", "Säärane mulk ehk Sada vakka tangusoola", "Saaremaa onupoeg" ja Tõnis Kipperi versiooni näidendist "Kosjaviinad" ning luulekompositsiooni "Mu isamaa on minu arm"

  9. Aktuaalsed teemad Brüsseli COPA-COGECA töögruppides / Ene Kärner

    Index Scriptorium Estoniae

    Kärner, Ene, 1973-

    2005-01-01

    Euroopa Liidu maaelu arengupoliitikast aastateks 2007-2013, ebasoodsamate piirkondade määratlemisest, riski- ja kriisijuhtimisest põllumajanduses, viina definitsioonist jt probleemidest, mis on arutusel Euroopa Liidu Põllumajandusorganisatsioonide Komitees (COPA) ja Põllumajanduskoostöö Keskkomitees (COGECA)

  10. Valimiskomisjonide otsuste ja toimingute vaidlustamine : [bakalaureusetöö] / Ene Soop ; Õigusinstituut ; juhendaja: Enn Markvart

    Index Scriptorium Estoniae

    Soop, Ene, 1974-

    1998-01-01

    Avalduste ja kaebuste esitamine, tähtajad, valimiskaebused konstitutsioonikohtus, kaebuste lahendamise erinevad viisid ja tähtajad, võimalikud parandused ja muudatused, keelenõudega seonduvad protestid.Vt. ka Õigusinstituudi toimetised (1998) nr. 1, lk. 10-11

  11. d ie penne st rydtu sse nd ie chr ist ene en he id eneg ed ur en ded ...

    African Journals Online (AJOL)

    Test

    is so oud as die Christendom self. Die doel van hierdie artikel is om kortliks na te gaan waiter aanvalle die Christene gedurende die eerste drie eeue van die kant van die heidene geleerdes ondervind, en hoe hulle daarop reageer het. Die heidense letterkunde tot ongeveer die middel van die tweede eeu bevat besonder ...

  12. Synthesis of 1-Methyl-3-oxo-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic Acid Methyl Ester

    Directory of Open Access Journals (Sweden)

    Gil Valdo José da Silva

    2005-11-01

    Full Text Available A simple and efficient method for the preparation of 1-methyl-3-oxo-7- oxabicyclo[2.2.1]hept-5-en-2-carboxylic acid methyl ester (1 is described. The first step is a highly regioselective Diels-Alder reaction between 2-methylfuran and methyl-3-bromo- propiolate. A remarkably difficult ketal hydrolysis reaction was effected by treatment with HCl, a simple reagent that was shown to be more efficient, in this case, than commonly used more elaborate methods.

  13. Educational objectives as the basis for successful coping at school / Leida Talts, Ene Mägi, Helle Sikka... [jt.

    Index Scriptorium Estoniae

    2007-01-01

    Artiklis käsitletakse sotsiaalsete ja eetiliste eesmärkide saavutatust kooliminevate laste rühmades ja esimese kooliaasta lõpus. Uurimus tugineb kolmele küsitlusele, mis viidi läbi ajavahemikus 2002-2004

  14. Den enes död, den andres bröd : En fallstudie i Fonus kriskommunikation

    OpenAIRE

    Orest Flavet, Sebastian

    2014-01-01

    Denna studie undersöker hur begravningsbyrån Fonus valde att bemöta en kritisk artikel, publicerad i Aftonbladet, med ett pressmeddelande som lades upp på den egna hemsidan. Uppsatsen undersöker först vilka retoriska verktyg som har använts i skapandet av detta meddelande, och sett från Benoits teori om Image Repair, vilka strategier som använts och hur användningen av dessa har sett ut. Därefter söker studien att praktiskt undersöka detta budskap genom att låta en utvald grupp respondenter t...

  15. Žene i rad u suvremenom društvu – značaj “orodnjenog” rada

    OpenAIRE

    Galić, Branka

    2011-01-01

    Promjene na poslu i obitelji daju zamaha promjenama u rodnim odnosima i obrnuto. Upravo kao što se životi žena i muškaraca mijenjaju, mijenjaju se i odnosi na tržištu rada i u obitelji. Ulazak žena na tržište rada kasnog 20. i početka 21. stoljeća značajno je pogodilo globalnu ekonomiju i označio početak procesa feminizacije rada širom globusa. Međutim, upliv žena u javnu sferu rada nije rezultirao socioekonomskim jednakostima između dviju rodnih grupa, muškaraca i žena. Različiti autori ukaz...

  16. Maja Cap Ferret's Prantsusmaal : võtmesõnaks on ökoarhitektuur / Anne Prommik, Ene Läkk

    Index Scriptorium Estoniae

    Prommik, Anne

    1999-01-01

    Mere kaldale puude vahele rajatud, saledatele tugisammastele tõstetud ranges stiilis maja on avatud vaid Archachoni rannale. Looduse säilitamiseks on iga maja läbiva puutüve ümber ehitatud metallkonstruktsioon. Tüved läbivad liigutatavat katust kummist 'varruka' kaudu. Projekteerija: Lacaton et Vassal (Bordeaux).

  17. Light-induced switching of 1,3-diazabicyclo-[3.1.0]hex-3-enes on gold nanoparticles

    Science.gov (United States)

    Mahmoodi, Nosrat O.; Ahmadi, Narges Khatoon; Ghavidast, Atefeh

    2018-05-01

    The fabrication of hybrid nanoassemblies involving sulfure-modified photochromic derivatives (SMPDs) on the gold nanoparticles (AuNPs) was carried out to investigate the influence of AuNPs surface plasmons on the SMPDs photoisomerization. The size of the AuNPs obtained was <30 nm in average diameter. Upon irradiation by alternating UV and Vis light, a reversible photochemical isomerization along with bathochromic shift in the absorption band takes place on the surface of the AuNPs in analogy with free SMPDs in solutions. Furthermore, in some cases a significant quenching of photochromic reactivity was observed due to the excited energy transfer from the photochromic molecules to the AuNPs core.

  18. Žene u slikarstvu impresionizma na prijelazu stoljeća - primjer Slave Raškaj

    OpenAIRE

    Mačečević, Iva

    2016-01-01

    U radu se predstavlja kratak pregled ženskog položaja u povijesti umjetnosti te se izdvaja pozicija žena i ženskog slikarstva na prijelazu stoljeća. Ističu se četiri impresionistice, njihov život i kako je to utjecalo na njihov opus. Izdvojeni su pojedini radovi u opusima Berthe Morisot, Mary Cassatt, Eve Gonzalès i Marie Bracquemond koji daju opći pregled o njihovoj umjetnosti u okviru impresionizma. Veći dio rada je posvećen životu i opusu Slave Raškaj. U njemu su izdvojena djela koja su pr...

  19. Marie Underi luule : mõnest tõlkeprobleemist / Ilse Lehiste ; inglise k. tlk. Ene-Reet Soovik

    Index Scriptorium Estoniae

    Lehiste, Ilse, 1922-2010

    2000-01-01

    Orig.: Marie Under's poetry: some problems of translation. Varem ilmunud: Lituanus, 1983, nr. 3. Kaasautor: Rimvydas Shilbajoris. M. Underi luuletuse "Täiskuu" tekst eesti k., tõlge inglise keelde (tlk. I. Lehiste) ja reaalune tõlge inglise keelde, lk. 256-260

  20. Eesti kooliõpilaste väärtushinnanguist ja huvialadest / Ingrid Rüütel, Ene-Margit Tiit

    Index Scriptorium Estoniae

    Rüütel, Ingrid, 1935-

    2005-01-01

    Artiklis analüüsitakse 2004. a. Eesti koolides läbi viidud ankeetküsitlusi teemal "Kooliõpilaste väärtushinnangud ja huvialad". Küsitleti 12-19-aastasi eestikeelsete koolide õpilasi kogu Eestist. Kokku vastas küsitlusele 345 õpilast

  1. Case note: Gerechtshof 's-Hertogenbosch (ABP partnerpensioen ene partner wordt verminderd met aan andere partner toekomend ABP bijzonder partnerpensioen)

    NARCIS (Netherlands)

    Reinhartz, B.E.

    2009-01-01

    De man is gehuwd geweest met mevrouw X tussen 1962 en 1976. Tussentijds heeft de man van 1986 tot 1990 samengewoond met mevrouw Z. In 1988 is er een samenlevingsovereenkomst gesloten tussen de man en vrouw Z. Tussen 1991 en 1995 hebben de man en mevrouw Z weer samengewoond. In 1994 heeft de man het

  2. Goethe loob väljendi : maailmakirjanduse kultuuripoliitika / David Damrosch ; tõlkinud Ene-Reet Soovik

    Index Scriptorium Estoniae

    Damrosch, David

    2007-01-01

    Johann Wolfgang von Goethe erasekretäri Peter Eckermanni teosest "Vestlused Goethega tema elu viimastel aastatel", Goethe vaadetest kirjandusele, maailmakirjanduse mõisest. Ka kirjanduse tõlkimisest tänapäeval, sinoloog Stephen Oweni vaadetest ja hiina luuletaja Bei Dao luulest. Artikkel sisaldab ka Bei Dao luuletuste näiteid

  3. Söötmisega disainitud piim tagab tervisliku toidukraami / Ene Tammsaar ; intervjueerinud Ain Alvela ; kommenteerinud Üllas Jaaska

    Index Scriptorium Estoniae

    Tammsaar, Ene, 1952-

    2014-01-01

    Et farmidest tööstusse minevast toorpiimast saaks toota maitsvaid ja tervislikke tooteid, peab toorpiim olema kõrgeima võimaliku kvaliteediga. Selle tagamiseks on piimatööstused koostöös teadlastega ette võtnud piima koostise disainimise

  4. "WhatsApp"ening in orthopedic care: a concise report from a 300-bedded tertiary care teaching center.

    Science.gov (United States)

    Khanna, Vishesh; Sambandam, Senthil N; Gul, Arif; Mounasamy, Varatharaj

    2015-07-01

    Smartphones have emerged as essential tools providing assistance in patient care, monitoring, rehabilitation, communication, diagnosis, teaching, research and reference. Among innumerable communication apps, WhatsApp has been widely popular and cost effective. The aim of our study was to report the impact of introduction of a smartphone app "WhatsApp" as an intradepartmental communication tool on (1) awareness of patient-related information, (2) efficiency of the handover process and (3) duration of traditional morning handovers among orthopedic residents in a 300-bedded tertiary care teaching center. Written handovers and paging used for communication at our center led to occasional inefficiencies among residents. Widespread use, low cost, availability and double password protection (phone lock and WhatsApp lock) made WhatsApp's group conversation feature an ideal tool for intradepartmental patient-related communication. Twenty-five consecutive admissions before and after WhatsApp (BW, AW) were included in the study. Eight orthopedic residents attempted fifty randomly arranged questions based on the twenty-five patients in each study period. A null hypothesis that introduction of WhatsApp group would neither increase the awareness of patient-related information nor improve the efficiency of the handovers among residents was assumed. A significant improvement observed in scores obtained by residents in the AW group led to rejection of the null hypothesis. The residents also reported swifter and efficient handovers after the introduction of WhatsApp. Our results indicate that the introduction of a smartphone app "WhatsApp" as an intradepartmental communication tool can bring about an improvement in patient-related awareness, communication and handovers among orthopedic residents.

  5. Rootsilik lapsepõlv ängi ja päikesepaiste vahel / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet, 1968-

    2007-01-01

    Arvustus: Tranströmer, Tomas. Suur on mõistatus ; Mälestused seiravad mind / rootsi keelest tõlkinud Tõnis Arnover ja Lennart-Hans Jürgenson ; järelsõna: Tõnis Arnover. Tallinn : Kultuurileht, 2007. (Loomingu raamatukogu ; 27)

  6. Rantsev v. Chipre & Rusia, App. No. 25965/04 (Eur. Ct. H.R. Ene. 7, 2010

    Directory of Open Access Journals (Sweden)

    Catharine A. MacKinnon

    2011-10-01

    Full Text Available En el artículo se analiza el caso Rantsev para determinar qué logra, y qué no logra, para enfrentar efectivamente la trata de mujeres; comentando favorablemente sus decisiones en materia de libertad, tortura y esclavitud y criticando parcialmente su decisión sobre el derecho a la vida. Las similitudes y convergencias que existen entre la agresión contra las mujeres y la prostitución, ambas entendidas como prácticas de desigualdad sexual, se consideran bases realistas y constructivas para el enfoque de la trata de mujeres.

  7. Eesti viipekeele kasutamise õiguse tagamine Eestis : [magistritöö] / Hendrick Rang ; Tartu Ülikool, õigusteaduskond ; juhendaja: Ene Andresen

    Index Scriptorium Estoniae

    Rang, Hendrick

    2014-01-01

    Kurtusest ja viipekeelest, viipekeele kui keele reguleerimisest, viipekeele kui puuet kompenseeriva suhtlusabivahendi reguleerimisest rahvusvahelises õiguses, viipekeele õiguslikust seisundist Eestis

  8. Villa Jaapanis Nagano maakonnas : võtmesõnaks on ökoarhitektuur / Anne Prommik, Ene Läkk

    Index Scriptorium Estoniae

    Prommik, Anne

    1999-01-01

    Tokio lähedal metsa keskel asuv kunstigalerii omanikust tellija villa, kus on ruum kunstiteoste eksponeerimiseks ja korter kahe magamistoa ning loodusvaatega vannitoaga. Maja baaselemendiks on ring. Planeeringus on tõmmatud kindlapiiriline joon avaliku ja eluruumi vahele (machiya-disain). Arhitekt Kazuyo Sejima & Associates.

  9. Sphinganine-Like Biogenesis of (E)-1-Nitropentadec-1-ene in Termite Soldiers of the Genus Prorhinotermes

    Czech Academy of Sciences Publication Activity Database

    Jirošová, Anna; Majer, Pavel; Jančařík, Andrej; Dolejšová, Klára; Tykva, Richard; Šobotník, Jan; Jiroš, Pavel; Hanus, Robert

    2014-01-01

    Roč. 15, č. 4 (2014), s. 533-536 ISSN 1439-4227 R&D Projects: GA ČR GP13-25137P Institutional support: RVO:61388963 Keywords : biosynthesis * natural products * nitro compounds * Prorhinotermes * termites Subject RIV: CE - Biochemistry Impact factor: 3.088, year: 2014

  10. Uroboros : [aus "Uroboros"] : [luuletused] / Ene Mihkelson ; tlk. Irja Grönholm ja Gisbert Jänicke

    Index Scriptorium Estoniae

    Mihkelson, Ene, 1944-2017-

    2006-01-01

    Sisu: Uroboros : "In der Nacht fragt heimlich jemand Wie heisst du..." ; "Am Meer stand ein Mann mit einer Sense..." ; "An dem Tag als es Kugeln regnete..." ; "Zum Zeitvertrieb ersteigerte ich mir auf einer Auktion ein paar..." ; "Sie hat sich mit der Zeit eingelassen und daraus..." ; Das Feld ; "Mutter ist wieder bei mir obgleich..." ; "Wir waren ein Mädchen Wir redeten..." ; "Als ich vier Jahre alt wurde Da wurde so viel..." ; "Wer ist dein Vater Der Fremde aus der Ferne..." ; "Das letzte Wort Das letzte Das letzte Das allein...". Orig.: Uroboros : "Öö aegu keegi küsib sala Mis su nimi on..." ; "Mere ees seisis vikatiga mees..." ; "Sel päeval kui sadas kuulivihma..." ; "Ajaviiteks ostsin enampakkumisel sõpru..." ; "Ta ajaga läinud on sohki ja sellest..." ; Põld ; "Mu ema on jälle mu juures kuigi..." ; "Meid oli üks türduk Me rääkisime..." ; "Kui olin saanud neljaseks Nii väga kiitis..." ; "Kes on su isa Kaugelt tulnud võõras..." ; "Viimast sõna Viimast Viimast Ainu..."

  11. Microfluidic monitoring of programmed cell death in living plant seed tissue

    DEFF Research Database (Denmark)

    Mark, Christina; Heiskanen, Arto; Zor, Kinga

    highly specific responses to the phytohormones gibberellic acid and abscisic acid. Combined with the increasing usage as a model for studying plant protein secretion, these properties make the aleurone layer ideal for maintenance in a microfluidics system (Fath, Angelika, et al., (2001), Plant Physiol...

  12. Konfliktne ja soe Iisrael / Signe-Fideelia Roots

    Index Scriptorium Estoniae

    Roots, Fideelia-Signe, 1976-

    2008-01-01

    "Port Performance'i" workshop'ist Iisraelis 19. IV-6. V, performance'ite esitlusest Tel Avivi kaasaegse kunsti keskuses (CCAs) 4. V. Organiseerijad: performance'i-kunstnikud BBB Johannes Deimling ja Angelika Fojtuch. Osalesid Signe-Fideelia Roots ja Katrin Tees Eestist, Dinoys Damman Šveitsist ja Mara Maglione Itaaliast. Muljeid Iisraelist, sealsest kunstielust

  13. Performance'is peab kõigel olema tähendus / Signe-Fideelia Roots

    Index Scriptorium Estoniae

    Roots, Fideelia-Signe, 1976-

    2006-01-01

    "Port Performance'i" workshop Gdanskis ajaloolises Stocznia laevatehases 7.-12. VIII. Idee autorid ja korraldajad olid performance'i-kunstnikud BBB Johannes Deimling (sünd. 1969) ja Angelika Fojtuch (sünd. 1978). Osalesid kunstiakadeemiate üliõpilased Saksamaalt, Inglismaalt, Šveitsist, Poolast ja Eestist (Signe-Fideelia Roots)

  14. Suur müüdikonverents Tartus / Evelin Banhard

    Index Scriptorium Estoniae

    Banhard, Evelin

    2008-01-01

    Tartus toimunud rahvusvahelisest konverentsist "Suurte kultuuriliste ja kirjanduslike müütide saatus tänapäeval". Pikemalt Liisa Saariluoma, Jüri Talveti, Angelika Stefanova, Tanel Lepsoo, Caroline De Wagteri, Sonia Bravo Utrera, Ana Martinoska, Marin Laagi, Rutt Hinrikuse, Jeanne Elisabeth Gleseneri, Sabine Coelsch-Foisneri, Harvey L. Hixi ja Hannu K. Riikoneni ettekannetest

  15. Are men universally more dismissing than women? Gender differences in romantic attachment across 62 cultural regions

    OpenAIRE

    Schmitt, David A.; Alcalay, Lidia; Allensworth, Melissa; Allik, Juri; Ault, Lara; Austers, Ivars; Bennett, Kevin L.; Bianchi, Gabriel; Boholst, Fredrick; Borg Cunen, Mary Ann; Braeckman, Johan; Brainerd, Edwin G.; Caral, Leo Gerard A.; Caron, Gabrielle; Casullo, Maria Martina

    2003-01-01

    The authors thank Susan Sprecher (USA), Del Paulhus (Canada), Glenn D. Wilson (England), Qazi Rahman (England), Alois Angleitner (Germany), Angelika Hofhansl (Austria), Tamio Imagawa (Japan), Minoru Wada (Japan), Junichi Taniguchi (Japan), and Yuji Kanemasa (Japan) for helping with data collection and contributing significantly to the samples used in this study.

  16. (E-2,2′-[3-(2-Nitrophenylprop-2-ene-1,1-diyl]bis(3-hydroxycyclohex-2-en-1-one

    Directory of Open Access Journals (Sweden)

    Joo Hwan Cha

    2012-01-01

    Full Text Available In the title compound, C21H21NO6, each of the cyclohexenone rings adopts a half-chair conformation. Each of the pairs of hydroxy and carbonyl O atoms are oriented to allow for the formation of intramolecular O—H...O hydrogen bonds, which are typical of xanthene derivatives.

  17. Thiol-ene Monolithic Pepsin Microreactor with a 3D-Printed Interface for Efficient UPLC-MS Peptide Mapping Analyses

    DEFF Research Database (Denmark)

    Jönsson, Alexander; Svejdal, Rasmus R; Bøgelund, Nanna

    2017-01-01

    To improve the sample handling, and reduce cost and preparation time, of peptide mapping LC-MS workflows in protein analytical research, we here investigate the possibility of replacing conventional enzymatic digestion methods with a polymer microfluidic chip based enzyme reactor. Off-stoichiomet...... used in LC-MS based protein analyses. The chip IMER is found to rival the conventional column in terms of digestion efficiency at comparable residence time and, using a 3D-printed interface, be directly interfaceable with LC-MS....

  18. Process for Biotransformation of Androsta-4-ene-3, 17-Dione (4-AD) to Androsta-1,4-Diene-3,17-Dione (ADD).

    Science.gov (United States)

    Prakash, Surya; Bajaj, Abhay

    2017-01-01

    Androsta-1,4-diene-3,17-dione (androstadienedione, ADD) is key intermediate for the organic synthesis of a variety of female sex hormones such as estrone, estradiol, estriol and other related derivatives. De novo synthesis of this molecule is not yet reported in any form of living system, i.e., microbial, plant, and animal. The structural complexities due to presence of several chiral carbon centers create significant hurdles in chemical synthesis of such molecules. Microbe-mediated biotransformation offer a highly reliable, cost-effective, and relatively non hazardous way for commercial manufacturing of steroidal key intermediates. Currently microbial biotransformations are extensively being exploited for large-scale production of basic intermediates such as androstenedione (AD), ADD, and several types of hydroxylated derivatives of androstane compounds. In this chapter several aspects of microbial biotransformation process of AD to ADD are discussed.

  19. Računarsko modelovanje samonavođene rakete sa pokretnim pratećim koordinatorom / Computer modeling of homing systems with a mobile accompanying coordinator

    Directory of Open Access Journals (Sweden)

    Stojadin Manojlović

    2003-03-01

    Full Text Available Sistemi vođenja i upravljanja raketama uopšte, uključujući i sisteme samovođenja kao njihov poseban oblik, složeni su sistemi koji zahtevaju primenu znanja iz vise oblasti, kako bi na precizan način mogli da se formiraju što realniji matematički modeli svih strukturnih elemenata. Na osnovu matematičkog modela moguće je stvoriti računarski model pomoću kojeg se vrši analiza dinamičkog ponašanja sistema. U ovom radu predstavljeno je programsko rešenje za modelovanje sistema samovođenja zasnovano na programskom jeziku MATLAB. Rešenje je implementirano na modularnom principu, što omogućava lakšu kontrolu eventualnih grešaka i olakšava nadogradnju novim komponentama, npr. drugi tip zakona vođenja. / Guidance and control systems, including homing systems, are complex systems requiring the application of knowledge from different areas in order to form precise mathematical models of all system elements. The computer model is based on the mathematical model of a homing system and it enables the system dynamical performance analysis. In this paper a computer model of the homing system is presented. The described software is open for upgrade, i.e. for another type of the guidance law.

  20. CCDC 820903: Experimental Crystal Structure Determination : (eta^5^-pentamethylcyclopentadienyl)-(1-benzyl-3-[tri(propan-2-yl)-phosphanylidene]triaz-1-ene)-chloro-ruthenium

    KAUST Repository

    Lamberti, Marina; Fortman, George C.; Poater, Albert; Broggi, Julie; Slawin, Alexandra M. Z.; Cavallo, Luigi; Nolan, Steven P.

    2013-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  1. Rahapesu ja terrorismi rahastamise tõkestamise seaduse kohaldamise probleemid notarite ametitegevuses : [magistritöö] / Veronika Aunpu ; Tartu Ülikool, õigusteaduskond ; juhendaja: Ene Andresen

    Index Scriptorium Estoniae

    Aunpu, Veronika

    2009-01-01

    Notarite kaasamisest rahapesu ja terrorismi rahastamise tõkestamiseks, tugevdatud hoolsusmeetmete kohaldamise vajalikkusele osundavatest riskidest notari ametitegevuses, notari kohustustest rahapesu või terrorismi rahastamise kahtlusega tehingute korral

  2. (1R,2R,3R,4S,5S-3-Methyl-8-oxabicyclo[3.2.1]oct-6-ene-2,4-diyl diacetate

    Directory of Open Access Journals (Sweden)

    Viktor A. Tafeenko

    2011-08-01

    Full Text Available The molecule of the title compound, C12H16O5, has crystallographically imposed mirror symmetry with the mirror plane passing through the endocyclic O atom and the mid-point of the double bond. In the crystal, molecules are linked by C—H...O hydrogen bonds, forming chains running along the a axis.

  3. Method for greenhouse gas emission assessments according to the article 75 of the 2010-788 law of July 12, 2010 bearing national commitment for the environment (ENE)

    International Nuclear Information System (INIS)

    2011-01-01

    This document presents mandatory methodological principles, optional prescriptions and optional recommendations for the assessment of greenhouse gas emissions. After having recalled some basic definitions, and regulatory arrangements and performance principles for greenhouse gas emission assessment, this document proposes a diagram indicating the main steps of such an assessment. It defines the organisational frame (for companies or communities), presents the concept of operational perimeter. It reviews the general principles of the assessment: global approach and priorities, calculation with respect to measurement, emission factors, gas global warming potential, reporting and reference year, uncertainty management, case of electricity, case of biomass CO 2 , cogeneration and electricity production from renewable energy, compensation. It presents the reporting format. Some aspects are more precisely presented or described in appendix

  4. VIP EE, Ms Ene Ergma, President of the Estonia Parliament (Riigikogu), Republic of Estonia (attending the 3rd World Conference of Speakers of Parliament in Geneva)

    CERN Multimedia

    2010-01-01

    She toured the LHC superconducting magnet test hall with Andrzej Siemko, leader of the machine protection and electrical integrity group in the technology department, and also saw the CERN Control Centre, the CMS experiment and the LHC tunnel.

  5. Kogesime suurepärast meeskonnatööd / Liisi Lembinen, Elena Sipria-Mironov ; intervjueerinud Õnne Mets, Ene Riet

    Index Scriptorium Estoniae

    Lembinen, Liisi

    2014-01-01

    Tartu Ülikooli Raamatukogu osales EOD-projektis 2009. aasta maist kuni 2014. aasta aprillini. Kuidas projekt toimis ja mida saavutati, vastavad direktori kt Liisi Lembinen ja projektijuht Elena Sipria-Mironov

  6. CCDC 889630: Experimental Crystal Structure Determination : Chloro-(eta^2^-pent-2-ene-1,5-diylbis(di-t-butylphosphine))-rhodium

    KAUST Repository

    Hayashi, Yukiko

    2013-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  7. Dimeric cyanobacterial cyclopent-4-ene-1,3-dione as selective inhibitor of Gram-positive bacteria growth: Bio-production approach and preparative isolation by HPCCC

    Czech Academy of Sciences Publication Activity Database

    Cheel, José; Bogdanová, K.; Ignatova, S.; Garrard, I.; Hewitson, P.; Kolář, M.; Kopecký, Jiří; Hrouzek, Pavel; Vacek, J.

    2016-01-01

    Roč. 18, SEP (2016), s. 244-249 ISSN 2211-9264 R&D Projects: GA MŠk EE2.3.30.0059; GA MŠk ED2.1.00/03.0110; GA MŠk(CZ) LO1416 Institutional support: RVO:61388971 Keywords : Phenolic cyclopentenedione * Natural antibiotic * Cyanobacteria Subject RIV: EE - Microbiology, Virology Impact factor: 3.994, year: 2016

  8. Ove rd ep en d en ceon wood-f ue l as a so u rc e of ho use hold ene ...

    African Journals Online (AJOL)

    2005-06-23

    Jun 23, 2005 ... s e x , marital stat u s , a n d e d u catio n leve l of ho u s e hold h e ad w e r e .... cluded because of the possibility that there are gen- ... ucation was added because of the belief that it is ... 1 The m unicip alit y ha s four hou s in g den s it y area s: low den - ... predicted values smooth the data and provide im-.

  9. FY 2001 report on the results of New Energy Adventure 2001 (advisory project); Shin ene adobencha 2001 (adobaizari jigyo) kekka hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-03-01

    For the purpose of deepening the understanding of new energy by general citizens, 'Clean Energy Festa' was held in Asahikawa city, Hokkaido, Takamatsu city, Kagawa prefecture, and Kamimashiki county, Kumamoto prefecture. The campaign at station was conducted at Yamagata station, Hiroshima station, Ogura station, Takamatsu station, Kobe station and Sapporo station, and the following were also carried out in various places of Japan: new energy lessons, visits to new energy facilities, and delivery of lectures on new energy. The program of Clean Energy Festa included the Dejimon (popular character doll) show, new energy quiz show, exhibition of new energy information and quiz about new energy, solar car workshop for parent/child, exhibition booths prepared by companies, corner for test ride on clean energy car, etc. As to visits to new energy facilities, visits were paid to snow/ice energy facilities, waste fuel production facilities, wind power generation facilities, photovoltaic power generation facilities, etc. Concerning the delivery of lectures on new energy, lectures were given on new energy and global environment, global warming, etc. (NEDO)

  10. Vahistatute võrdne kohtlemine Eesti vanglates ja arestimajades : [magistritöö] / Sigrid Nurm ; Tartu Ülikool, õigusteaduskond ; juhendajad: Ene Andresen, Berit Aaviksoo

    Index Scriptorium Estoniae

    Nurm, Sigrid, 1988-

    2013-01-01

    Võrdse kohtlemise põhiõigusest, kinnipidamistingimustest ja riietusest, keelatud esemetest, kambrivälisest tegevusest, massiteabevahendite kättesaadavusest, kinnipidamisasutuse välisest suhtlemisest, ettepanekutest ebavõrdse kohtlemise kõrvaldamiseks

  11. Üldine kaubandus (toidukaupade turg) : toidukaupade väliskaubanduse bilanss [2003-2004] / Õrne Pill, Liia Laanes, Ene Maadvere

    Index Scriptorium Estoniae

    Pill, Õrne

    2005-01-01

    Ilmunud ka: Agriculture and the development of rural life : overview 2004/2005. - Tallinn, 2005, lk. 55-65. Põllumajandussaaduste ekspordimaht kasvas eelmise aasta sama perioodiga võrreldes 5,1% ning impordimaht vähenes 1,8%, kaubandusbilansi negatiivne saldo moodustas 4507,7 mln krooni. Diagrammid

  12. Ärkav kaunitar : I rahvusvaheline teatrifestival "Talveöö unenägu" 28. -31. XII 2000 Tallinna Linnateatris / Ene Paaver

    Index Scriptorium Estoniae

    Paaver, Ene, 1963-

    2001-01-01

    Rahvusvaheline festival "Talveöö unenägu" Tallinna Linnateatris 28.- 30. dets. Lavastused : "K. I. Kuritööst" (lav. Kama Ginkas, Moskva Noorsooteater), "Gargantua ja Pantagruel" (lav. Stanislavas Rubinovas, Kaunase Noorsooteater), "Preili Pollinger" (lav. Edith Koerber, Saksa Tri-Bühne), "Rusudekorjajad" (lav. Nika Brettschneider, Viini Brett Theater)

  13. Tööjõuvahetus viib teise keskkonda : mida kogesid Ida-Virumaa raamatukoguhoidjad Pärnus ja Rakveres töötades / Ene Riet

    Index Scriptorium Estoniae

    Riet, Ene, 1954-

    2010-01-01

    Integratsiooni ja Migratsiooni Sihtasutuse Meie Inimesed tööjõuvahetusprogrammis osalenud räägivad oma muljetest. Pärnu Keskraamatukogus töötasid Kohtla-Järve Keskraamatukogu töötajad Tatjana Agafonova ja Alla Rõtova ning vastuvõtjateks ja tugiisikuteks olid Lenna Eliste, Krista Visas ja Heinike Sinijärv. Lääne-Virumaa Keskraamatukogus olid Jõhvi Keskraamatukogu töötajad Natalja Jakovleva ja Tamara Saar, vastu võtsid Leigi Kütt ja Lea Lehtmets

  14. 1α,6β,7β,11α,15β-Pentahydroxy-7α,20-epoxy-ent-kaur-16-ene

    Directory of Open Access Journals (Sweden)

    Chuang Feng

    2010-02-01

    Full Text Available The title compound, C20H30O6, a natural ent-kaurane diterpenoid, named nervosanin B, was obtained from the medicinal plant Isodon serra. It is composed of four rings with the expected trans and cis junctions. One of the six-membered rings is in a chair conformation, the other two are in boat conformations and the five-membered ring adopts an evenlope conformation. The molecules stack along the a axis and are linked together by intermolecular O—H...O hydrogen bonds. Two intramolecular O—H...O interactions also occur.

  15. 15α,20β-Dihydroxy-6β-methoxy-6,7-seco-6,20-epoxy-1,7-olide-ent-kaur-16-ene

    Directory of Open Access Journals (Sweden)

    Fu-Lin Yan

    2010-04-01

    Full Text Available The title compound, C21H30O6, a natural ent-kaurane diterpenoid, was obtained from the medicinal plant Isodon serra. The five rings in the molecule exhibit the expected cis and trans junctions. The three six-membered rings adopt chair, twist-boat and boat conformations, while two five-membered rings adopt envelope conformations. There are two molecules in the asymmetric unit, related by a non-crystallographic twofold screw axis; the main difference is in the different degrees of distortion of ring B. In the crystal, the molecules are linked by intermolecular O—H...O hydrogen bonds, forming chains along the b axis.

  16. 6β-Acetoxy-1α,7β,11β,15β-tetrahydroxy-7α,20-epoxy-ent-kaur-16-ene

    Directory of Open Access Journals (Sweden)

    Fu-Lin Yan

    2010-02-01

    Full Text Available The title compound, C22H32O7, a natural ent-kaurane diterpenoid also referred to as Maoyecrystal F, was obtained from the medicinal plant Isodon nervosa. There are four rings with the expected cis and trans junctions. Cyclohexane ring A adopts a chair conformation, rings B and C adopt boat conformations, while the five-membered ring has an envelope conformation. The molecules stack along the a axis in the crystal and are linked together by intermolecular O—H...O hydrogen bonds.

  17. Atypical McMurry Cross-Coupling Reactions Leading to a New Series of Potent Antiproliferative Compounds Bearing the Key [Ferrocenyl-Ene-Phenol] Motif

    Directory of Open Access Journals (Sweden)

    Pascal Pigeon

    2014-07-01

    Full Text Available In the course of the preparation of a series of ferrocenyl derivatives of diethylstilbestrol (DES, in which one of the 4-hydroxyphenyl moieties was replaced by a ferrocenyl group, the McMurry reaction of chloropropionylferrocene with a number of mono-aryl ketones unexpectedly yielded the hydroxylated ferrocenyl DES derivatives, 5a–c, in poor yields (10%–16%. These compounds showed high activity on the hormone-independent breast cancer cell line MDA-MB-231 with IC50 values ranging from 0.14 to 0.36 µM. Surprisingly, non-hydroxylated ferrocenyl DES, 4, showed only an IC50 value of 1.14 µM, illustrating the importance of the hydroxyethyl function in this promising new series. For comparison, McMurry reactions of the shorter chain analogue chloroacetylferrocene were carried out to see the difference in behaviour with mono-aryl ketones versus a diaryl ketone. The effect of changing the length of the alkyl chain adjacent to the phenolic substituent of the hydroxylated ferrocenyl DES was studied, a mechanistic rationale to account for the unexpected products is proposed, and the antiproliferative activities of all of these compounds on MDA-MB-231 cells lines were measured and compared. X-ray crystal structures of cross-coupled products and of pinacol-pinacolone rearrangements are reported.

  18. Riigisaladus kui informatsioonivabaduse piirang ja sellele juurdepääs : [bakalaureusetöö] / Ene Lehiste ; Tartu Ülikool, õigusteaduskond ; juhendaja: Kalle Merusk

    Index Scriptorium Estoniae

    Lehiste, Ene

    2001-01-01

    Salastatud info kui infovabaduse piirang, riigisaladuse mõiste kehtivas õiguses, salastatud teabe kaitse meetodid, riigisaladuse juurdepääsu alused, julgeolekukontrolli läbiviimine (NATO-s, WEU-s)

  19. Üks kaame naine väikses kambris ... : [luuletused] / Gyula Illyés ; tlk. Sander Liivak, Ene Asu-Õunas

    Index Scriptorium Estoniae

    Illyés, Gyula

    2004-01-01

    Sisu: Üks kaame naine väikses kambris ... ; Sa ei saa pageda ; Purukslöödud vägi ; Mäe otsas puhkan ... ; Kodumaa kõrgel ; Magav naine ; Doleo, ergo surm ; Bart̤k ; Üks lause vägivallast ; Jalutuskäik varjuga ; Tuuline öö ; Liginev külm ; Viltune puri ; Näod ; Aovalgus ; Korraloomine ; Värdjate sünd ; Charoni vene ; Tõusul ; Leegihingaja ; Lähenev vaikus ; Teekond videvikul ; Pärg. Andmeid autori kohta lk. 87-88

  20. Riigivastutus ilma riigi vastutuseta : notari, kohtutäituri ja vandetõlgi isiklik ametivastutus Euroopa õiguse ja riigiõiguse vaatepunktist / Ene Andresen

    Index Scriptorium Estoniae

    Andresen, Ene, 1977-

    2006-01-01

    Kas ja millistel tingimustel võib riik asendada oma vastutuse füüsilisest isikust avaliku võimu kandja vastutusega ning kuivõrd see on notari, kohtutäituri ja vandetõlgi puhul sisuliselt põhjendatud. Artikkel on valminud Eesti Teadusfondi grandilepingu nr. GOIAO6464 alusel finantseeritud uurimistöö raames

  1. WSN ene rgy balance multi-hop lc ustering routing algorithm%能量均衡多跳分簇路由算法

    Institute of Scientific and Technical Information of China (English)

    叶润; 王缓缓

    2014-01-01

    The lifetime of ZigBee wireless sensor network is directly related to energy consumption of nodes .In order to extend the life of the network, the clustering routing methods are used.The improved clustering routing algo-rithm-EBMHC ( energy balance multi-hop clustering routing algorithm) , which adopts centralized rotation-cluste-ring method and distributed competition method of cluster head.This makes the network’ s idle nodes sleep and cluster head node work acting as multiple transmission.It also has data fusion and routing maintenance in a single cycle, so as to make full and effective use of network energy.Hierarchical management can solve imbalance of net-work node energy consumption.The simulation shows that EBMHC algorithm outperforms LEACH and SEP, making the network energy consumption more balanced and prolonging the network lifetime.%ZigBee无线传感器网络的生存寿命与节点的能耗直接相关。为了延长网络的寿命,通常采用分簇路由方法。通过集中成簇管理以及分布簇头竞争的能量均衡多跳分簇路由算法EBMHC( energy balance multi-hop clustering rou-ting algorithm),在一个周期内,使得网络空闲节点休眠,簇头节点担任多条传输、数据融合以及路由维护的功能,以充分有效利用网络能量。分层管理方式可以缓解网络节点能耗不均衡问题。通过仿真表明, EBMHC算法优于LEACH和SEP算法,使网络能耗更均衡,延长了网络生存周期。

  2. Korra ja kaose piiril : vastukaja Jaan Einasto, Ene Ergma ja Lauri Aaspõllu artiklile "Postimehes"("Uuenduslik arengutee, 16.08.2002) / Karl Kello

    Index Scriptorium Estoniae

    Kello, Karl, 1950-

    2002-01-01

    Akadeemik Jaan Einasto mõtteid : Eesti riigi põhiprioriteediks peaks olema haridus, mis viib Eestit edasi; tuleks tõsta õpetajate palku, teha sihikindlaid investeeringuid haridusse, arendada õppimisoskust, valmisolekut kogu aeg õppida jne.

  3. Riigi ülesannete täitmine lennuliiklusteeninduse korraldamisel : [bakalaureusetöö] / Imre Ernits ; Tartu Ülikool, õigusteaduskond ; juhendaja: Ene Andresen

    Index Scriptorium Estoniae

    Ernits, Imre

    2010-01-01

    Lennuohutuse tagamise funktsioonidest ja sellest tulenevatest riiklikest ülesannetest, Euroopa Liidu ja rahvusvahelisest õigusest tulenevatest nõuetest lennuliiklusteeninduse korraldamisele. Lennuliiklusteeninduse korraldusest Eesti õiguses, põhiseaduslikest probleemidest

  4. Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation.

    Directory of Open Access Journals (Sweden)

    Lauryn Samelko

    Full Text Available Cobalt alloy debris has been implicated as causative in the early failure of some designs of current total joint implants. The ability of implant debris to cause excessive inflammation via danger signaling (NLRP3 inflammasome vs. pathogen associated pattern recognition receptors (e.g. Toll-like receptors; TLRs remains controversial. Recently, specific non-conserved histidines on human TLR4 have been shown activated by cobalt and nickel ions in solution. However, whether this TLR activation is directly or indirectly an effect of metals or secondary endogenous alarmins (danger-associated molecular patterns, DAMPs elicited by danger signaling, remains unknown and contentious. Our study indicates that in both a human macrophage cell line (THP-1 and primary human macrophages, as well as an in vivo murine model of inflammatory osteolysis, that Cobalt-alloy particle induced NLRP3 inflammasome danger signaling inflammatory responses were highly dominant relative to TLR4 activation, as measured respectively by IL-1β or TNF-α, IL-6, IL-10, tissue histology and quantitative bone loss measurement. Despite the lack of metal binding histidines H456 and H458 in murine TLR4, murine calvaria challenge with Cobalt alloy particles induced significant macrophage driven in vivo inflammation and bone loss inflammatory osteolysis, whereas LPS calvaria challenge alone did not. Additionally, no significant increase (p500pg/mL. Therefore, not only do the results of this investigation support Cobalt alloy danger signaling induced inflammation, but under normal homeostasis low levels of hematogenous PAMPs (<2pg/mL from Gram-negative bacteria, seem to have negligible contribution to the danger signaling responses elicited by Cobalt alloy metal implant debris. This suggests the unique nature of Cobalt alloy particle bioreactivity is strong enough to illicit danger signaling that secondarily activate concomitant TLR activation, and may in part explain Cobalt particulate associated inflammatory and toxicity-like reactions of specific orthopedic implants.

  5. Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation

    OpenAIRE

    Samelko, Lauryn; Landgraeber, Stefan; McAllister, Kyron; Jacobs, Joshua; Hallab, Nadim James

    2016-01-01

    Cobalt alloy debris has been implicated as causative in the early failure of some designs of current total joint implants. The ability of implant debris to cause excessive inflammation via danger signaling (NLRP3 inflammasome) vs. pathogen associated pattern recognition receptors (e.g. Toll-like receptors; TLRs) remains controversial. Recently, specific non-conserved histidines on human TLR4 have been shown activated by cobalt and nickel ions in solution. However, whether this TLR activation ...

  6. Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation

    Science.gov (United States)

    Samelko, Lauryn; Landgraeber, Stefan; McAllister, Kyron; Jacobs, Joshua; Hallab, Nadim James

    2016-01-01

    Cobalt alloy debris has been implicated as causative in the early failure of some designs of current total joint implants. The ability of implant debris to cause excessive inflammation via danger signaling (NLRP3 inflammasome) vs. pathogen associated pattern recognition receptors (e.g. Toll-like receptors; TLRs) remains controversial. Recently, specific non-conserved histidines on human TLR4 have been shown activated by cobalt and nickel ions in solution. However, whether this TLR activation is directly or indirectly an effect of metals or secondary endogenous alarmins (danger-associated molecular patterns, DAMPs) elicited by danger signaling, remains unknown and contentious. Our study indicates that in both a human macrophage cell line (THP-1) and primary human macrophages, as well as an in vivo murine model of inflammatory osteolysis, that Cobalt-alloy particle induced NLRP3 inflammasome danger signaling inflammatory responses were highly dominant relative to TLR4 activation, as measured respectively by IL-1β or TNF-α, IL-6, IL-10, tissue histology and quantitative bone loss measurement. Despite the lack of metal binding histidines H456 and H458 in murine TLR4, murine calvaria challenge with Cobalt alloy particles induced significant macrophage driven in vivo inflammation and bone loss inflammatory osteolysis, whereas LPS calvaria challenge alone did not. Additionally, no significant increase (p500pg/mL). Therefore, not only do the results of this investigation support Cobalt alloy danger signaling induced inflammation, but under normal homeostasis low levels of hematogenous PAMPs (<2pg/mL) from Gram-negative bacteria, seem to have negligible contribution to the danger signaling responses elicited by Cobalt alloy metal implant debris. This suggests the unique nature of Cobalt alloy particle bioreactivity is strong enough to illicit danger signaling that secondarily activate concomitant TLR activation, and may in part explain Cobalt particulate associated inflammatory and toxicity-like reactions of specific orthopedic implants. PMID:27467577

  7. Disclosure of Professional Secrecy – A Criminal Law Analysis and Dilemmas (Dileme kaznivega dejanja neupravičene izdaje poklicne skrivnosti

    Directory of Open Access Journals (Sweden)

    Miha Šepec

    2017-12-01

    Full Text Available Disclosure of professional secrecy is incriminated in Article 142 of the Slovenian Penal Code (KZ-1. The offence protects the privacy of individuals in order to protect them from abuse when personal information and secrets are communicated to persons of certain professions (doctors, lawyers, priests, etc.. The issue is analyzed briefly; however, the context raises extremely complex dogmatic issues, particularly in the direction when unlawfulness of the crime shall be excluded, whether it is reasonable that such a complex offence is not prosecuted ex officio or upon request by the injured person, and the nature of relationship between the offence of disclosure of professional secrecy according to Article 142 and offences under Articles 280 (Failure to Inform Authorities of Preparations for Crime and 281 (Failure to Provide Information of Crime or Perpetrator of the Slovenian Penal Code. The aim of this paper is to highlight some legal dogmatic issues that have not yet been discussed in legal practice. On the other hand, the authors would also like to urge the legislature to amend the current criminal offence of disclosure of professional secrecy.

  8. Enantiomerically pure (1S,5R) and racemic 3-(1-benzothiophen-2-yl)-8-azoniabicyclo 3.2.1 oct-2-ene acetate

    DEFF Research Database (Denmark)

    Frostrup, B.; Peters, D.; Bond, A. D.

    2012-01-01

    of the molecules in the asymmetric unit. The major component of the disorder has the thiophene ring in the same position as in the racemate, but generates a higher-energy molecular conformation. The minor disorder component has different intermolecular interactions but retains a more stable molecular conformation....... isostructural with the racemate, except that the glide symmetry is violated by interchange of CH and CH2 groups within the seven-membered ring. The space-group symmetry is reduced to P1 with two molecules in the asymmetric unit. The enantiomer structure shows disorder of the thiophene ring for one...

  9. Tavakoolide õpetajate suhtumine kõigi laste koosõpetamisse ja nende oskused erivajadustega laste õpetamisel tavaklassis / Ene Mägi, Aina Haljaste

    Index Scriptorium Estoniae

    Mägi, Ene, 1939-

    2001-01-01

    1998/99. õa. Eesti tavakoolides töötavate õpetajate seas läbi viidud küsitlusest: milline on õpetajate suhtumine kõigi laste koosõpetamisse ning missugused on õpetajate oskused ja vajadused erivajadustega laste õpetamisel tavaklassis

  10. COMPARATIVE STUDY OF THE THERAPEUTIC EFFICIENCY OF OXITETRACICLINE, IMIDOCARB AND DIMINAzENE, USED IN THE TREATMENT OF EQUINE THOROUGBREED HEMOPARASITES

    OpenAIRE

    Comerma Steffensen, Simon Gabriel; Arrieta-Mendoza, D.; Morales, A; Viloria, D; Romero, N.; Morales, G.; Kassar, M.

    2012-01-01

    It presents a comparative study of the therapeutic efficacy of oxytetracycline, imidocarb and diminaze- ne, used in the treatment of equine hemoparasitosis Thoroughbreds. We studied a total of 105 horses, Tho- roughbreds, all under 2 years old, during the quarantine period November to December 2011. They practice a clinical examination, blood samples were taken for a complete blood count and blood smear for disposal of taxon. They were then medicated with single dose intramuscular (IM) as fol...

  11. Pakkujate võrdne kohtlemine riigihankemenetlusest kõrvaldamisel ja pakkujate kvalifitseerimisel : [magistritöö] / Piia Kulm ; Tartu Ülikool, õigusteaduskond ; juhendajad: Ene Andresen, Veiko Vaske

    Index Scriptorium Estoniae

    Kulm, Piia

    2009-01-01

    Võrdse kohtlemise põhimõtte sisust ja kohaldamisest ning selle põhimõtte järgimise tagamisest riigihangete õiguses, pakkujate kõrvaldamise ja pakkujate kvalifitseerimise etapi erinevustest, pakkujate hankemenetlusest kõrvaldamise ning kvalifitseerimise etapist

  12. Eesti pensionisüsteem Euroopa Liidu ühiste pensionimärkide valguses / Lauri Leppik, Ene-Margit Tiit, Andres Võrk

    Index Scriptorium Estoniae

    Leppik, Lauri, 1964-

    2004-01-01

    Eesti pensionisüsteemi probleemid on senistest liikmesriikidest erinevad: pensionisüsteemi jätkusuutlikkus on hea ja pensionäride vaesusrisk ei ole kõrge, kuid asendusmäär on suhteliselt madal. See tähendab, et ei suudeta tagada EL-i pensionieesmärki, mis taotleb, et inimesel oleks pensionile jäädes võimalk säilitada oma varasem elatustase. Diagramm. Tabelid. Graafikud

  13. North Carolina eestlaskond tähistas Eesti Vabariigi 90. aastapäeva / Airi Vaga ; foto: Ene-Inga Juergen

    Index Scriptorium Estoniae

    Vaga, Airi, 1940-

    2008-01-01

    Dr. Arvo ja Mirjam Ederma kodus Belmontis tähistati pidulikult Eesti Vabariigi juubelit. Kohal viibisid ja sõnavõtuga esinesid ka president Toomas Hendrik Ilveselt Valgetähe IV klassi teenetemärgi pälvinud praost Thomas Vaga ja presidendi kunagine skautmaster Elmar "Emu" Saarniit

  14. 40-Godišnjica institucije Cambridge Crystallographic Data Centre posvećene pohranjivanju podataka o molekularnim i kristalnim strukturama -

    Directory of Open Access Journals (Sweden)

    Molčanov, K.

    2006-06-01

    Full Text Available The article is dedicated to 40th anniversary of The Cambridge Crystallographic Data Centre (CCDC, the world-known centre (http://www.ccdc.cam.ac.uk responsible for deposition and control of crystallographic data, including atomic coordinates that define the three-dimensional structures of organic molecules and metal complexes containing organic ligands. Cambride Structural Database (CSD, one among the first established electronic databases, nowadays is the most significant crystallographic database in the world. CSD has about 400,000 deposited structures. The use of the extensive database, which is growing rapidly, needs support of efficient and sophisticated software for searching, analysing and visualising structural data. The seminal role of CSD in the research related to crystallography, chemistry, material sciences, solid state physics and chemistry, life sciences, pharmacology, and in particular in drug design, has been documented in more than 1300 scientific papers. The important issues of CCDC are the accuracy of deposited data and development of software that enables a wide variety of applications. Such demanding project requires higly competent team of experts; thus the article brings into focus the scientific approach of the team based on the long tradition in crystallography, modelling and informatics. The article is not dedicated to 40th anniversary of the centre only, but it also reveals how Cambridge Structural Database can be used in the research and teaching. The use of electronic media and computer graphics makes “data mining" very efficient and useful but also esthetically appealing due to the molecular architecture. At the Rudjer Bošković Institute, Zagreb, Croatia there is The National Affiliated Centre of Cambridge Crystallographic Data Centre responsible for communication and dissemination of CSD in Croatia, Slovenia and Macedonia. The use of CSD is illustrated by two examples performed and published by the presenting authors: a the analysis of the less-common hydrogen bonds with the ester oxygen atom as a proton acceptor, and b topological analysis of tubular assemblies of macrocyclic polythianes extensively described in the references 24 and 28.

  15. Assistance to countries which are on their way to energy conservation and preservation of the environment. Sho ene tojokoku enjo to kankyo hozen

    Energy Technology Data Exchange (ETDEWEB)

    Osaka, Kunikazu [The Energy Conservation Center, Tokyo, (Japan)

    1990-02-20

    Energy conservation is considered the most realistic measure against the problem of the global warming for the time being. Developing countries consume about 30% of the energy consumed in the world. Although their absolute consumption amount is little at the moment, their energy consumption is increasing year after year. Efficiency of their energy utilization is low because compared with advanced countries their equipments are of old type and their technologies are behind the times. It is, therefore, estimated possible to conserve energy by 30% with e improvements and plant and equipment investments. It is very effective to introduce Japanese advanced energy conservation technologies to these countries through international cooperation. In fact investigation commissions composed of experts have been dispatched to Thailand, China and Argentine, experts have been dispatched to foreign countries to stay there for several years and give assistance, trainees have been received, and study and training meetings have been held already. Seminars with Japanese lecturers have been also held in many foreign countries since 1983. As for the future prospect, establishment of core organizations as the base of technologies and human resources in foreign countries for the further promotion of assistance is expected. 7 figs.

  16. NEDO Forum 2000. New energy and energy conservation introducing and proliferating project session (toward promotion of introducing new energies and energy conservation); Shin'ene shoene donyu fukyu jigyo session. Shin'ene shoene no donyu sokushin ni mukete

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-09-01

    The following themes were presented at this session: (1) the history and roles of the NEDO's introduction and promotion projects, (2) expectation and prospects to introduction and promotion of new energy and energy conservation technologies, (3) energy innovation in houses and buildings actively using new energies and energy conservation means, (4) works on introducing new energies by using the private finance initiative (PFI), and (5) the last resort for energy conservation promoting measures in the industrial domain (high-performance industrial furnace technologies). In Item 3, design cases intended for sustainable buildings were introduced. In Item 4, the PFI is explained as a means to use as much fund and management know-how in private sectors as possible in improving the social capitals and providing high-quality public services. In Japan, the PFI promotion law was established in July 1999 (the law concerning promotion of improvements in public facilities by utilizing funds in private sectors). Introductions are given on the wide area wastes disposal project in Kimitsu Area, the PFI model project for power generation of everyday use at Kanamachi Water Purification Plant of the Tokyo Metropolitan Water Supply Bureau, and the Omuta RDF power generation project. In Item 5, descriptions are given on a new high-performance industrial furnace using the combustion mechanism of 'high-temperature air combustion' created from preheated air at temperatures higher than spontaneous combustion temperature. (NEDO)

  17. CAPHIGAS Project: Design of a Novel WGS-Adsorbent-Membrane Hybrid System for the Simultaneous Capture of CO{sub 2} and Production of H2 (Ref.: Ene2009-08002); Proyecto CAPHIGAS: Diseno de un Sistema Hibrido WGS-Adsorbente-Membrana para la Captura de CO{sub 2} con Produccion de H{sub 2} (Ref: Ene2009-08002)

    Energy Technology Data Exchange (ETDEWEB)

    Marano, M.; Barreiro, M. M.; Sanchez, J. M.

    2014-02-01

    This report describes the general objective, tasks and main results and conclusions drawn within CAPHIGAS Project, Plan Nacional de I+D+I 2008-2011, financed by the Spanish Ministry of Science and Innovation and carried out by the Valorization of Fuels and Wastes Group of Ciemat. The general objective of the project was the design and development of a novel hybrid system for the simultaneous removal of CO{sub 2} and production of H{sub 2} using a WGS catalyst-adsorbent membrane configuration. The novel system proposed has provided new insight into the adsorption and reaction processes and has allowed an optimization of the operating conditions to take advantage of the synergies between both processes. In this report main future activities are also reported. (Author)

  18. Joonistus läheb moodi! II / Tiit Pääsuke, Anu Juurak

    Index Scriptorium Estoniae

    Pääsuke, Tiit, 1941-

    2006-01-01

    Eesti Kunstiakadeemia joonistuse õppetooli juhatatajad Tiit Pääsuke ja Anu Juurak joonistuse tähendusest ja rollist teiste kunstiliikide seas, suundumustest ja stiilidest ajalises mõttes, kuni 10. IX Tallinna Kunstihoones avatud rahvusvahelisest joonistuste näitusest "Improvisatsioon". 3. IX tantsib näitusel Helena Ehrenbusch, joonistavad Angelika Schneider ja Flo Kasearu, 3.-10. IX improviseerivad kooliõpilased Loit Jõekalda juhendamisel

  19. Entre el perdón y el paredón: Preguntas y dilemas de la justicia ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    In this way, Entre el perdón y el paredón helps not only to identify the challenges that Colombian society will have to face to overcome its current armed conflict, but also ... Angelika Rettberg, PhD, is a professor in the Department of Political Science in the Faculty of Social Sciences at the Universidad de los Andes, and is the ...

  20. Eesti Kunstimuuseumi kevadine suurprojekt

    Index Scriptorium Estoniae

    2005-01-01

    6. maist Väliskunsti Muuseumis näitus "Šveitsi muusa. Angelika Kauffmann (1741-1807)". Väljas on Churi (Bündner Kunstmuseum Chur) ja Väliskunsti Muuseumi tööd. Näituse initsiaator ja Šveitsi-poolne korraldaja Giuliano Crivelli, Eesti-poolne kuraator Kadi Polli. Seminari kava 6. V, esinevad Beat Stutzer, Mai Levin, Kadi Polli, Renate Berger, Sirje Kivimäe, Ave Tarrend

  1. Stereoselective synthesis of (2S,3S,4Z-4-fluoro-1,3-dihydroxy-2-(octadecanoylaminooctadec-4-ene, [(Z-4-fluoroceramide], and its phase behavior at the air/water interface

    Directory of Open Access Journals (Sweden)

    2008-04-01

    Full Text Available BackgroundSphingolipids belong to the most important constituents of the membranes of eukaryotic cells. As intermediates in sphingolipid metabolism, sphingosine and its N-octadecanoyl-derivative, ceramide, exhibit a variety of biological functions. These compounds play a crucial role in many essential biological processes such as cell growth, cell differentiation, cell recognition and apoptosis. More specifically, sphingolipids are crucial e.g. for the function of the skin because they contribute to the formation of the water permeability barrier consisting of a highly organized multilaminar lipid matrix of free fatty acids, cholesterol and ceramides containing additional hydroxyl groups in the sphingosin part and longer fatty acid amide functions.ResultsIn a short synthetic route (2S,3S-4-fluorosphingosine and 4-fluoroceramide, the fluorinated analogues of the natural products, D-erythro-sphingosine and ceramide, have been prepared. The key step of the synthetic sequence is an asymmetric aldol reaction of (Z-2-fluorohexadec-2-enal, prepared in three steps from tetradecanal, with an enantiopure N-protected iminoglycinate. Deprotection of the imino function and reduction of the ester group led to the 4-fluorosphingosine, which on acetylation with stearoyl chloride gave 4-fluoroceramide. After careful HPLC purification of the latter compound its phase behavior was investigated by Langmuir film balance technique and compared to that of natural ceramide. While the isotherms are quite similar in shape, they differ significantly in the starting point of increasing film pressure (56 or 67 Å2/molecule and in the film collapse pressure (38 or 56 mN/m for ceramide and 4-fluoroceramide, respectively. Moreover, the hysteresis curves are very different. While consecutive isothermic compression – expansion cycles are reversible for the 4-fluoro derivative, substantial substance loss into the subphase or irreversible formation of multi-layers was observed for natural ceramide.ConclusionsAsymmetric aldol reaction proved to be successful for the preparation of enantiopure 4-fluoroceramide. Surface/pressure isotherms and hysteresis curves of ceramide and its 4-fluoro derivative showed that the presence of fluorine leads to stronger intermolecular interactions between the hydrophobic chains of neighboring molecules, and therefore to increasing stability of the monolayer of 4-fluoroceramide at the air water interface.

  2. The Rearrangement of 1-Methylcyclohex-1-ene during the Hydrodesulfurization of FCC Gasoline over Supported Co(Ni)Mo/Al2O3 Sulfide Catalysts: the Isolation and Identification of Branched Cyclic C7 Olefins

    Czech Academy of Sciences Publication Activity Database

    Žáček, Petr; Kaluža, Luděk; Karban, Jindřich; Storch, Jan; Sýkora, Jan

    2014-01-01

    Roč. 112, č. 2 (2014), s. 335-346 ISSN 1878-5190 R&D Projects: GA ČR GAP106/11/0902 Institutional support: RVO:67985858 ; RVO:61388963 Keywords : hydrodesulfurization * olefin hydrogenation * branched cyclic olefins Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.170, year: 2014

  3. Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males

    Directory of Open Access Journals (Sweden)

    Kreider Richard

    2007-10-01

    Full Text Available Abstract The purpose of this study was to determine the effects of 6-OXO, a purported nutritional aromatase inhibitor, in a dose dependent manner on body composition, serum hormone levels, and clinical safety markers in resistance trained males. Sixteen males were supplemented with either 300 mg or 600 mg of 6-OXO in a double-blind manner for eight weeks. Blood and urine samples were obtained at weeks 0, 1, 3, 8, and 11 (after a 3-week washout period. Blood samples were analyzed for total testosterone (TT, free testosterone (FT, dihydrotestosterone (DHT, estradiol, estriol, estrone, SHBG, leutinizing hormone (LH, follicle stimulating hormone (FSH, growth hormone (GH, cortisol, FT/estradiol (T/E. Blood and urine were also analyzed for clinical chemistry markers. Data were analyzed with two-way MANOVA. For all of the serum hormones, there were no significant differences between groups (p > 0.05. Compared to baseline, free testosterone underwent overall increases of 90% for 300 mg 6-OXO and 84% for 600 mg, respectively (p 0.05 and clinical safety markers were not adversely affected with ingestion of either supplement dose (p > 0.05. While neither of the 6-OXO dosages appears to have any negative effects on clinical chemistry markers, supplementation at a daily dosage of 300 mg and 600 mg for eight weeks did not completely inhibit aromatase activity, yet significantly increased FT, DHT, and T/E.

  4. CAPHIGAS Project: Design of a Novel WGS-Adsorbent-Membrane Hybrid System for the Simultaneous Capture of CO2 and Production of H2 (Ref.: Ene2009-08002)

    International Nuclear Information System (INIS)

    Marano, M.; Barreiro, M. M.; Sanchez, J. M.

    2014-01-01

    This report describes the general objective, tasks and main results and conclusions drawn within CAPHIGAS Project, Plan Nacional de I+D+I 2008-2011, financed by the Spanish Ministry of Science and Innovation and carried out by the Valorization of Fuels and Wastes Group of Ciemat. The general objective of the project was the design and development of a novel hybrid system for the simultaneous removal of CO 2 and production of H 2 using a WGS catalyst-adsorbent membrane configuration. The novel system proposed has provided new insight into the adsorption and reaction processes and has allowed an optimization of the operating conditions to take advantage of the synergies between both processes. In this report main future activities are also reported. (Author)

  5. Methodological guide for communities greenhouse gas emission assessments according to the article 75 of the 2010-788 law of July 12, 2010 bearing national commitment for the environment (ENE)

    International Nuclear Information System (INIS)

    2011-01-01

    After some basic definitions, this document describes the approach chosen to count greenhouse gas emissions as they are defined in the law: identification of emissions to be counted in greenhouse gas emission assessments, wider framework of district climate-energy plans. It describes how the general methodology is implemented, and more particularly in the case of a district or community. One can find in appendix: the strategic framework for regional climate air and energy scheme, a list of possible methodological principles within the frame of a district approach, and the case of emissions related to waste processing and of associated avoided emissions

  6. 4,5,7,8,17-Pentahydroxy-14,18-dimethyl-6-methylene-3,10-dioxapentacyclo[9.8.0.01,7.04,19.013,18]nonadec-14-ene-9,16-dione methanol solvate dihydrate

    Directory of Open Access Journals (Sweden)

    Chin Hoe Teh

    2009-04-01

    Full Text Available The title quassinoid compound, C20H24O9·CH3OH·2H2O, is a natural eurycomanone isolated from the roots of Eurycoma longifolia. The molecules contain a fused five-ring system, with one tetrahydrofuran ring adopting an envelope conformation, one tetrahydropyran-2-one ring in a screw boat conformation, one cyclohexenone ring in a half-chair conformation and two cyclohexane rings in chair conformations. Intramolecular C—H...O interactions generate S(5 ring motifs and an O—H...O interaction generates an S(7 ring motif. In the crystal, molecules are linked via intermolecular O—H...O interactions along the b axis and further stacked along a axis. The absolute configuration of the title compound was inferred from previously solved structures of its analogues.

  7. Traducción jurídica cinematográfica EN-ES Un análisis práctico: Algunos hombres buenos (Rob Reiner, 1992)

    OpenAIRE

    Díaz Moreno, Martín

    2017-01-01

    TFG RECOMENDADO POR EL CENTRO. Para abordar la traducción jurídica, debemos comenzar hablando de los lenguajes de especialidad, para después centrarnos en el lenguaje jurídico como uno de ellos. Si tenemos en mente esta categorización y también el hecho de que, como lengua de especialidad, el lenguaje jurídico plantea numerosos problemas al traductor, podemos asegurar que se trata de una de las modalidades más complejas de llevar a cabo. El cine por su parte es, como lo definía Pasolini, “...

  8. Effect of Promotion Metals on the Activity of MoS2/ZrO2 Catalyst in the Parallel Hydrodesulfurization of 1-Benzothiophene and Hydrogenation of 1-Methyl-Cyclohex-1-ene.

    Czech Academy of Sciences Publication Activity Database

    Kaluža, Luděk; Gulková, Daniela

    2016-01-01

    Roč. 118, č. 1 (2016), s. 313-324 ISSN 1878-5190 R&D Projects: GA ČR GAP106/11/0902 Institutional support: RVO:67985858 Keywords : hydrodesulfurization * hydrogenation * support effect Subject RIV: CI - Industrial Chemistry , Chemical Engineering Impact factor: 1.264, year: 2016

  9. Fiscal 1999 achievement report on development of wide-area energy utilization network system. Research on energy system design technology (Research on Eco-Energy City systematization); Eco ene toshi no system ka kenkyu 1999 nendo seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-05-01

    Efforts are being exerted to develop systems for effectively utilizing various kinds of waste heat in presence in cities and their neighborhood. In fiscal 1999, investigations were conducted into cases of low temperature waste heat utilization at 16 locations in Japan and into trends of heat utilization in five European countries, with a visit paid to European District Heating Association. There are 128 district heat supplying sites in service in Japan, of which 25 handles low temperature waste heat. As for their types of utilization, 12 are of the temperature difference energy utilization type while 13 are of the heat recovery type. When it comes to the system details, the importance of proper selection of structures and materials for heat accumulating systems and heat exchangers on the secondary side should be emphasized although it is the heat pump that assumes the key role. In Europe, indications are that district systems are developing into wide-area networks and that they are growing increasingly marketable. In the northern and eastern parts of Europe, 30-70% of demand for heat is met by district heating. Waste heat from power generation is the heat source, and this occupies 30-80% of the whole. Thanks to the introduction of the environmental tax, in addition, environments are now complete under which recoverable energy utilization will enjoy an advantageous position. (NEDO)

  10. (4S)-4-(3,4-Dichloro?phen?yl)-1?-methyl-4?-phenyl-3,4-dihydronaphthalene-2-spiro-3?-pyrrolidine-2?-spiro-1??-acenaphthyl?ene-1,2??(2H,1??H)-dione

    OpenAIRE

    Murugan, R.; Gunasekaran, B.; Narayanan, S. Sriman; Manivannan, V.

    2008-01-01

    In the title compound, C37H27Cl2NO2, the 3,4-dichloro?phenyl ring makes a dihedral angle of 46.66?(6)? with the phenyl ring. The mol?ecular structure is stabilized by weak intra?molecular C?H?O inter?actions and the crystal structure is stabilized by weak inter?molecular C?H?O inter?actions. The C?C?C?C?C five-membered ring is planar, while the C?C?C?C?N five-membered ring adopts a half-chair conformation.

  11. Rändeandmete kvaliteet ja rändesuundumused Eestis aastatel 2000-2005 = The quality of migration data and the trends of migration in Estonia in 2000-2005 / Alis Tammur, Tiit Tammaru, Ene- Margit Tiit

    Index Scriptorium Estoniae

    Tammur, Alis

    2006-01-01

    Eesti statistilise rahvastikuarvestuse alus on olnud viimase rahvaloenduse rahvaarv, millele lisatakse omavalitsusüksuste kaupa registripõhiselt kogutavad sünnid, surmad ning sisse- ja väljaränne. Rahvaloenduse ja rahvastikuregistri andmete põhimõtteline erinevus. Sise- ja välisrände arvestamise probleemid, rändesuundumuste analüüs. Diagramm. Tabelid

  12. Eesti õiguse vastavus direktiivile 2003/109/EÜ pikaajalise elaniku staatuse saamist reguleerivate sätete osas : [magistritöö] / Maret Kruus ; Tartu Ülikool, õigusteaduskond ; juhendaja: Ene Andresen

    Index Scriptorium Estoniae

    Kruus, Maret

    2014-01-01

    Direktiivi 2003/109/EÜ ülevõtmise üldküsimustest, sisulistest tingimustest pikaajalise elaniku staatuse saamiseks, menetluslikest nõuetest pikaajalise elaniku staatuse saamiseks ja õiguskaitsega seonduvatest probleemidest

  13. C60 and Sc3N@C80(TMB-PPO) derivatives as constituents of singlet oxygen generating, thiol-ene polymer nanocomposites

    OpenAIRE

    Ashli R. Toles; Janice Paige Buchanan; Kyle A. Guess; Emily M. Barker

    2016-01-01

    Numerous functionalization methods have been employed to increase the solubility, and therefore, the processability of fullerenes in composite structures, and of these radical addition reactions continue to be an important methodology. C60 and Sc3N@C80 derivatives were prepared via radical addition of the photodecomposition products from the commercial photoinitiator TMB-PPO, yielding C60(TMB-PPO)5 and Sc3N@C80(TMB-PPO)3 as preferred soluble derivatives obtained in high yields. Characterizati...

  14. A combined pharmacophore modeling, 3D-QSAR and molecular docking study of substituted bicyclo-[3.3.0]oct-2-enes as liver receptor homolog-1 (LRH-1) agonists

    Science.gov (United States)

    Lalit, Manisha; Gangwal, Rahul P.; Dhoke, Gaurao V.; Damre, Mangesh V.; Khandelwal, Kanchan; Sangamwar, Abhay T.

    2013-10-01

    A combined pharmacophore modelling, 3D-QSAR and molecular docking approach was employed to reveal structural and chemical features essential for the development of small molecules as LRH-1 agonists. The best HypoGen pharmacophore hypothesis (Hypo1) consists of one hydrogen-bond donor (HBD), two general hydrophobic (H), one hydrophobic aromatic (HYAr) and one hydrophobic aliphatic (HYA) feature. It has exhibited high correlation coefficient of 0.927, cost difference of 85.178 bit and low RMS value of 1.411. This pharmacophore hypothesis was cross-validated using test set, decoy set and Cat-Scramble methodology. Subsequently, validated pharmacophore hypothesis was used in the screening of small chemical databases. Further, 3D-QSAR models were developed based on the alignment obtained using substructure alignment. The best CoMFA and CoMSIA model has exhibited excellent rncv2 values of 0.991 and 0.987, and rcv2 values of 0.767 and 0.703, respectively. CoMFA predicted rpred2 of 0.87 and CoMSIA predicted rpred2 of 0.78 showed that the predicted values were in good agreement with the experimental values. Molecular docking analysis reveals that π-π interaction with His390 and hydrogen bond interaction with His390/Arg393 is essential for LRH-1 agonistic activity. The results from pharmacophore modelling, 3D-QSAR and molecular docking are complementary to each other and could serve as a powerful tool for the discovery of potent small molecules as LRH-1 agonists.

  15. Hiina tänapäeva arhitektuur - karmiilmeline, aga põnev / Zhang Ke, Zhang Hong, Xiaodu Liu ; interv. Hanna Läkk ja Ene Läkk

    Index Scriptorium Estoniae

    Zhang Ke

    2006-01-01

    Intervjuu Hiina arhitektuuribüroo Standardarchitecture arhitektide Zhang Ke ja Zhang Hongiga ning arhitektuuribüroo Urbanus arhitekti Xiaodu Liuga Hollandis Hiina tänapäeva tutvustaval näitusel. Hiina arhitektide haridusest, oma arhitektuuribüroode töödest, tänapäeva hiina arhitektuurist, põhiprobleemidest

  16. Upgrading of Gasification Gases by means of a Catalytic Membrane Reactor: WGS Catalysts and Inorganic Palladium Membranes HENRECA Project (ENE2004-07758-CO2-01). Final Report; Estudios de Enriquecimiento en H{sub 2} de Gases de Gasificacion mediante el Uso Reactor Catalitico de Membranas: Catalizadores WGS y Membranas Inorganicas de Paladio. Informe Final Proyecto HENRECA (ENE2004-07758-C02-01)

    Energy Technology Data Exchange (ETDEWEB)

    Maranon Bujan, M.; Sanchez Hervas, J. M.; Barreiro Carou, M. del

    2008-07-01

    The combination of a CO catalytic converter with a highly hydrogen selective membrane out stands as a very promising technology for the upgrading of biomass gasification gases. The advantages of this combined system over the traditional two stages WGS technology has been investigated within the HENRECA project, financed under the Spanish PN 2004-2007 of the Ministry of Science and Technology. This project started in September 2004 and had a duration of three years. The Division of Combustion and Gasification of CIEMAT participates in this project in three main activities: the study of the catalytic activity of WGS catalysts synthesised by the other partner of the project (University Rey Juan Carlos), the design of the reaction-separation system and the design and construction of a bench-scale pilot plant where the performance of the membranes prepared by URJC and the catalytic membrane system were investigated. This report describes the activities carried out within the project and the main results obtained. (Author) 14 ref.

  17. AMNT 2014. Key topic: Reactor operation, safety - report. Pt. 3

    Energy Technology Data Exchange (ETDEWEB)

    Bohnstedt, Angelika [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Programm Nukleare Sicherheitsforschung (NUKLEAR); Mull, Thomas [AREVA GmbH, Erlangen (Germany). Nuclear Fusion, HTR and Transverse Issues (PTDH-G); Starflinger, Joerg [Stuttgart Univ. (Germany). Inst. fuer Kernenergetik und Energiesysteme (IKE)

    2015-01-15

    Summary report on the following sessions of the Annual Conference on Nuclear Technology held in Frankfurt, 6 to 8 May 2014: - Reactor Operation, Safety: Radiation Protection (Angelika Bohnstedt); - Competence, Innovation, Regulation: Fusion Technology - Optimisation Steps in the ITER Design (Thomas Mull); - Competence, Innovation, Regulation: Education, Expert Knowledge, Knowledge Transfer (Joerg Starflinger). The other Sessions of the Key Topics 'Reactor Operation, Safety', 'Competence, Innovation, Regulation' and 'Fuel, Decommissioning and Disposal' have been covered in atw 10 and 12 (2015) and will be covered in further issues of atw.

  18. Mis tuleb

    Index Scriptorium Estoniae

    2008-01-01

    12. III avatakse Eesti Põllumajandusmuuseumi rohelises saalis Raine A. Sahrmani fotonäitus "Looduse värvid". Tartu, Tallinna ja Pärnu niplispitsi tegijate tööde näitus Tartumaa muuseumis kuni 15. III, 8. III töötuba, juhendab Angelika Nöps. 24. III avatakse Iisaku muuseumis põllenäitus, mille eksponaadid on pärit muuseumi kogudest ja eraisikutelt. 26. III avatakse Viljandi muuseumis näitus Hilja Rieti postkaartidest

  19. Sleep characteristics, sleep problems, and associations of self-efficacy among German university students

    OpenAIRE

    Schlarb, Angelika A; Kulessa, Dominika; Gulewitsch, Marco D

    2012-01-01

    Angelika A Schlarb1,2, Dominika Kulessa1,*, Marco D Gulewitsch1,*1Faculty of Science, Department of Psychology, University of Tübingen, 2Faculty of Psychology, University of Koblenz-Landau, Germany*These authors contributed equally to this workBackground: Sleep problems, especially insomnia, are a common complaint among adults. International studies on university students have shown prevalence rates between 4.7% and 36.2% for sleep difficulties, and 13.1% and 28.1% for insomnia. Slee...

  20. Eesti keel eestlaste emotsioonidest / Haldur Õim

    Index Scriptorium Estoniae

    Õim, Haldur, 1942-

    2004-01-01

    Arvustus: Vainik, Ene. Lexical knowledge of emotions: the structure, variability and semantics of the Estonian emotion vocabulary. Tartu : Tartu University Press, 2004. (Dissertationes linguisticae Universitatis Tartuensis ; 5)

  1. Prague quadrennial 14.06-20.06/2007. Short play: crisis of forties flood after rain/ Vladimir Anshon

    Index Scriptorium Estoniae

    Anšon, Vladimir, 1963-

    2010-01-01

    XI rahvusvahelisest Praha lavastuskunstnike kvadriennaalist (Prague Quadrennial). Eesti rahvuslikust väljapanekust, kuraator Ene-Liis Semper ja Eesti Kunstiakadeemia väljapanekust, kuraator Lilja Blumenfeld

  2. Ostame maja! / Kersti Pikk, Aet Piel, Piret Tali

    Index Scriptorium Estoniae

    Pikk, Kersti

    2007-01-01

    Võrreldakse kolme eramut - Pirital, Viimsis (Arhitektuuriagentuur OÜ - arhitektid Inga Raukas, Toomas Tammis, Karli Luik ja Renee Puusepp) ja Harku vallas Vatslas. Lk. Oberhausi kinnisvaraspetsialisti Ene Arro kommentaar

  3. Jan Gehli teose "Linnad inimestele" ilmumine = Publication of an Estonian-language Edition of Jan Gehl's Cities for People / Yoko Alender, Liina Teder, Neeme Lopp

    Index Scriptorium Estoniae

    Alender, Yoko, 1979-

    2016-01-01

    Taani arhitektist Jan Gehlist ja tema raamatust "Linnad inimestele". Eestikeelse väljaande toimkond: Yoko Alender, Neeme Lopp, Liina Teder, Eneli Rohtla. Maastikuarhitektuuri aastapreemia nominent 2016

  4. Agenda kultuuripealinna ArtGendast / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    1998-01-01

    24. maini Stockholmi Kulturhusetis avatud Balti mere maade noortebiennaalist 'ArtGenda'. Peakorraldaja Beate Sydhoff. Eestlaste - Ene-Liis Semper, Martin Pedanik, Andrus Kõresaar, Marko Laimre - esinemisest.

  5. AG Queer Studies (Hg.: Verqueerte Verhältnisse. Intersektionale, ökonomiekritische und strategische Interventionen. Hamburg: Männerschwarm Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Heinz-Jürgen Voß

    2009-11-01

    Full Text Available Der vorliegende Band enthält Beiträge zu den aktuell intensiv geführten Debatten um die Notwendigkeit einer deutlichen Positionierung von Queer Theorie zu Theorien der Ökonomiekritik und Intersektionalität. Dabei werden historische und aktuelle Beispiele herangezogen. Exzellent und besonders hervorzuheben sind die Aufsätze von Jin Haritaworn – ein anti-rassistischer Beitrag, der sich fundiert in aktuelle politische Queer-Auseinandersetzungen einmischt – sowie von Jo Bucher und Angelika Göres, die an einem zeitgeschichtlichen Beispiel queerende Momente des Widerstands herausarbeiten. Wie der vor acht Jahren erschienene erste Band der AG Queer Studies an der Hamburger Universität ist auch dieser für den deutschsprachigen Raum hochaktuell und wärmstens zu empfehlen.The volume at hand contains articles on the current and intense debate over the necessity of queer theory’s clear position in relation to theories of economic critique and intersectionality. It does so using historical and current examples. Essays deserving of special note include an article by Jin Haritaworn that engages in current queer political discussions and an article by Jo Bucher and Angelika Göres that highlights queer moments of resistance using a contemporary example. As was the case with the first volume of the AG Queer Studies at Hamburg University, published eight years ago, this volume is extremely current for the German-language market and is highly recommended.

  6. Kontserdisari kutsub "Klavessiinisalongi"

    Index Scriptorium Estoniae

    2008-01-01

    Rakvere Kaurikooli saalis toimuvatest kontsertidest: 7. dets."iViva Espagna!" (esinevad klavessiiniduo Ene Nael - Kristiina Are ja näitleja Tarmo Song), 15. veebr. "Häälemeelne" (laulja Kelli Pärnaste ja kitarrist Tiit Korsar, klavessinist Ene Nael) ja 26. apr. "Fiori musicali" (Tallinna Vanalinna Hariduskolleegiumi, Tallinna Muusikakeskkooli ja Rakvere Kaurikooli klavessiiniõpilased)

  7. Inert Reassessment Document for Poly(oxyethylene) adducts of mixed phytosterols

    Science.gov (United States)

    Poly(oxyethy1ene) adducts of mixed phytosterols is uncategorized as to list classification status. Based upon the reasonable certainty of no harm safety finding, the List 4B classification for poly(oxyethy1ene) adducts of mixed phytosterols is affirmed.

  8. Nasha "Russkaja galereja" v Madride

    Index Scriptorium Estoniae

    2005-01-01

    Kaasaegse kunsti laat ARCO Madridis. Osaleb "Vene galerii" Tallinnast näitusega TRINITY. Galerist Masha Melnikova. Osalevad Ene-Liis Semper ja Moskva kunstnikud Anton Litvin ning Bogdan Mamonov. Ene-Liis Semper näitab videokunsti, Anton Litvin fotoprojekti ja Bogdan Mamonov realistlikke portreid. Näitus märtsis Vene saatkonna galeriis Tallinnas

  9. La eneñanza aprendizaje de contenidos selectos y el fortalecimiento de la identidad nacional en alumnos de educación básica regular nevel secundaria de la Institución Educativa Pedro Ruíz Gallo, año 2014

    OpenAIRE

    Olave Zapata, Miguel Ángel

    2015-01-01

    Esta tesis tiene como propósito fundamental sensibilizar a docentes y dicentes sobre la importancia y relevancia del fortalecimiento de la Identidad Nacional en la educación básica regular nivel secundario, para ayudar a mejorar la integración de los jóvenes a la sociedad peruana; logrando en ellos ciudadanos comprometidos con el sentimiento de pertenencia que tenemos por la nación peruana, la identidad supone identificarnos con el patrimonio nacional, con los valores, tradiciones, historia, ...

  10. Development of a wide-area energy utilization network system (research on a technology to design an energy system). FY 1998 report on achievements of research on systematizing ECO and ENERGY cities; Koiki energy riyo network system kaihatsu (energy system sekkei gijutsu no kenkyu). 1998 nendo eko ene toshi no system ka kenkyu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    As a research on systematizing ECO and ENERGY cities, surveys and analyses were performed on the actual state of introducing district heat supply systems utilizing difference waste heats including factory waste heat. Waste heat from electric power generation is utilized for district heat supply in Japan at 122 points or about 20% of the district heat supply points in operation as of March 1998. The number is in the increasing trend in recent years, and the future potential of its introduction can be said high as the history thereof is still short. Its introduction form is accounted mostly for by building cogeneration or plant cogeneration. Back-up facilities for the case when waste heat supply stops because of regular facility checks are provided by the heat supply business operators, which impede the economy of the system. In the U.S., the Public Utility Regulatory Policy act motivated installation of cogeneration and off-peak power generation systems for district heat supply. Technical maps (for waste heat sources and different waste heat utilization systems) were prepared based on the surveys to discuss the future measures. (NEDO)

  11. Synthesis, crystal structure, and H/D exchange of the inside protonated form of the cage imine 4,8,12-triaza-1-azoniatricyclo[6.6.3.2(4,12)]nonadec-1(15)-ene. A model for proton transfer through an aliphatic membrane

    DEFF Research Database (Denmark)

    Springborg, Johan; Nielsen, Bente; Olsen, Carl Erik

    2002-01-01

    belonging to the triazacyclononane entity. The imine double bond is situated between the N-atom of the triazacyclononane entity and the C-atom belonging to one of the three trimethylene bridges. The imine 2 is stable in acidic solution and the inside coordinated proton is very robust in acidic solution......, which gave K-im = 1.57(1) x 10(-5) M at 25 degreesC, DeltaSdegrees = -83(1) J mol(-1) K-1 and DeltaHdegrees = 2,6(3) kJ mol(-1) at 1 = 1.0 M (NaCl). The inside coordinated proton in 3 is labile in basic solution and the rate for NH/ND exchange was determined by H-1 NMR at three different temperatures....... The reaction followed the expression k(obs) = k(ex)[OD-] with k(ex) = 0.0978(30) dm(3) mol (1) s(-1) at 25 degreesC, DeltaSdegrees = 87(4) J mol(-1) K-1, and DeltaHdegrees = 104.9(11) kJ mol(-1) at I = 1.0 M (NaCl). The exchange rate is more than 5 x 106 times faster than that of the parent saturated cage 1...

  12. Evaluación de la incidencia y los factores de riesgo para hemorragia intraventricular (HIV en la cohorte de recién nacidos prematuros atendidos en la unidad neonatal del HUSVP, de Medellín, en el período comprendido entre ene. de 1999 y dic. de 2004 Incidence and risk factors of intraventricular hemorrhage in preterm newborns

    Directory of Open Access Journals (Sweden)

    Yira Sánchez Hidalgo

    2007-12-01

    Full Text Available La hemorragia intraventricular (HIV es la principal complicación neurológica de los recién nacidos prematuros, cuyas frecuencia y gravedad aumentan con el menor peso al nacer y la menor edad gestacional. Se han encontrado otros factores asociados con el aumento o disminución de su frecuencia. Objetivo: determinar la incidencia de HIV en prematuros atendidos en el Hospital Universitario San Vicente de Paúl (HUSVP, de Medellín, Colombia, entre 1999 y 2004 y establecer su asociación con condiciones de la madre y del recién nacido. Metodología: estudio retrospectivo de los prematuros menores de 32 semanas y por debajo de 1.500 gramos, atendidos en el HUSVP entre 1999 y 2004. Se calculó una muestra de 330 historias clínicas, seleccionadas en forma aleatoria, con un nivel de confianza de 95%, error del 3% y poder del 80%,con base en una incidencia del 15% de HIV en la población general. Resultados: la incidencia encontrada de HIV fue 29,8%. Como factores protectores se encontraron los siguientes: parto por cesárea, parto en un centro de tercer nivel y maduración pulmonar. Como factores que aumentaron el riesgo de HIV se encontraron: parto vaginal, edad gestacional menor de 28 semanas, uso de surfactante, ventilación mecánica, cateterismo umbilical, acidosis e hipercapnia. Conclusiones: se debe insistir en la importancia de que haya programas adecuados de control prenatal para tratar de disminuir la frecuencia de parto prematuro, procurar la remisión oportuna de las gestantes de alto riesgo a centros de referencia, estimular el uso antenatal de esteroides y el control cuidadoso de los parámetros ventilatorios en los pacientes que requieran este soporte, buscando mantener un adecuado equilibrio ácido-base en los recién nacidos. Introduction: intraventricular hemorrhage is the main neurological complication of preterm newborns. Its frequency and severity increase as gestational age and weight at birth decrease. Other factors have been described that may influence its incidence. Objective: to determine the incidence of intraventricular hemorrhage at the Neonatal Care Unit of the Hospital Universitario San Vicente de Paúl, in Medellín, Colombia, from 1999 to 2004, and to establish its association with maternal and newborn conditions. Results: an incidence of HIV of 29.8% was found. Cesarean section, labor in a third level attention center and pulmonary maturation were found to be protective factors. On the other hand, the incidence of HIV increased with the following circumstances: vaginal labor, gestational age under 28 weeks, use of surfactant, mechanical ventilation, acidosis, hypercapnia and umbilical catheterism. Conclusions: prenatal programs have to be reinforced in order to avoid preterm labor; high risk pregnant women ought to be opportunely referred to specialized centers; the antenatal use of steroids is to be encouraged and careful management of ventilatory parameters avoiding acidosis is mandatory.

  13. Scientific writing and communication papers, proposals, and presentations

    CERN Document Server

    Hofmann, Angelika H

    2014-01-01

    Scientific Writing and Communication: Papers, Proposals, and Presentations, Second Edition, serves as a comprehensive " reference guide to scientific writing and communication. The second edition of Angelika Hofmann's successful text covers all the areas of scientific communication that a scientist needs to know and master in order to successfully promote his or her research and career. This unique "all-in-one" handbook begins with a discussion of the basic principles of scientific writing style and composition and then applies these principles to writing research papers, review articles, grant proposals, research statements, and resumes, as well as to preparing academic presentations and posters. Scientific Writing and Communication: Papers, Proposals, and Presentations has been used successfully for a number of years in courses on scientific writing at various universities and institutes worldwide. Readers of the second edition will find numerous new examples and exercises, many with an expanded interdiscip...

  14. OLD AND SAD — DEPRESSION IN LATER LIFE

    African Journals Online (AJOL)

    Enrique

    of elderly citizens as the AIDS epidemic plateaus. Increased life expectancy will be due to improved health and social conditions. Hence clinicians .... ive social network. Studies have ... spread, and one outcome is the damp- ening down of an ...

  15. New labdane diterpenes from Solidago canadensis.

    Science.gov (United States)

    Wangensteen, Helle; Phan, Thi T; Rise, Frode; Halvorsen, Trine G; Malterud, Karl E

    2012-01-01

    The ethanol extract of roots of Solidago canadensis yielded eight labdane-type diterpenes. Five of those were new natural compounds (9,13,15,16-bisepoxy-labdane-7-ene-6,15-dione (3a), 13-epi-9,13,15,16-bisepoxy-labdane-7-ene-6,15-dione (3b), 15,16-epoxy-labdane-7,13-diene-6,16-dione (5), 15-ethoxy-9,13,15,16-bisepoxy-labdane-7-ene-6-one (6a) and 13-epi-15-ethoxy-9,13,15,16-bisepoxy-labdane-7-ene-6-one (6b). The known labdane diterpenes deoxysolidagenone (1), solidagenone (2) and 15,16-epoxy-labdane-7,13-diene-6,15-dione (4) were also isolated. Chemical structures were determined using 1D and 2D NMR techniques and MS analysis.

  16. Extra Strong Super Light / Magdalena Lewoc

    Index Scriptorium Estoniae

    Lewoc, Magdalena

    2003-01-01

    2003. a. Szczecini Rahvusmuuseumis toimunud 5. rahvusvahelisest kunstinäitusest võtsid osa poola, saksa, rootsi, soome, leedu, läti, ukraina ja eesti kunstnikud. Pikemalt Ene-Liis Semperi ja Jaan Toomiku loomingust

  17. Tectonic reactivation in the Indian Ocean: Evidences from seamount morphology and manganese nodule characteristics

    Digital Repository Service at National Institute of Oceanography (India)

    Mukhopadhyay, R.; Khadge, N.H.

    The Central Indian Ocean Basin (CIOB) was subjected to tectonic reactivation in geological past which is unusual for a basin occurring on an apparently single tectonic plate. ENE-WSW trending latitude parallel zone of reactivation across the central...

  18. chama et al

    African Journals Online (AJOL)

    PUBLICATIONS1

    electrical equipment (EEE) globally has in- creased its obsolescence ... which is about 5% of municipal waste (OECD, ... a result of extensive pollution, the river is virtu- ally dead. ... ene bags and transported in an ice cooler. A ... Quality control.

  19. Kunstiteaduslik doktoritöö EKA-s kaitstud / Ingrid Ruudi

    Index Scriptorium Estoniae

    Ruudi, Ingrid

    2005-01-01

    Heie Treier "Kohalik modernsus kunstis. Eesti varamodernistliku kunsti teoreetiline ja ajalooline kontseptualiseerimine ning Karl Pärsimägi paradigmaleidmise perioodil". Juhendaja Thomas McEvilley, eelretsensent Katrin Kivimaa ja Ene Lamp. Oponent Jaak Kangilaski

  20. stakeholders' perceptions of cocoa extension constraints in ghana

    African Journals Online (AJOL)

    User

    The key findings were that all concurred that productivity should be boosted to improve the lot of farmers and ... coa trees infected with the deadly swollen shoot virus disease. .... ence in decision-making processes are strength- ened. District.

  1. Application of microwave irradiation to organic liquid phase reactions

    International Nuclear Information System (INIS)

    Huang Kun; Liu Hua; Ji Xuelin

    1994-01-01

    Microwave irradiation has been used in organic liquid phase reactions to significantly reduce the reaction time and improve the yield. The proposed mechanism, the development of techniques and reactions, such as Diels-Alder, ene, rearrangement reactions etc., are discussed

  2. Reference: 83 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ene cause hypersensitivity to exogenous ethylene and its precursor 1-aminocyclopr...ed EIN3 levels, even in the absence of exogenous ethylene. Collectively, our results show that the SCF(EBF1/

  3. Naised, kes ei oska võidelda / Tiina Tauraite

    Index Scriptorium Estoniae

    Tauraite, Tiina, 1976-

    2011-01-01

    Toimetuse intervjuu näitleja Tiina Tauraitega Sulev Keeduse filmist "Kirjad Inglile" (Eesti-Soome 2011), stsenaristid Madis Kõiv ja Sulev Keedus, produtsent Kaie-Ene Rääk. Tiina Tauraite - arhivaar Edda osatäitja

  4. Estraadi comeback. Ojasoo - Semperi "Nafta!" kui XXI sajandi estraadilavastus / Ott Karulin

    Index Scriptorium Estoniae

    Karulin, Ott, 1980-

    2006-01-01

    Estraadi sugemetega etendustest ja estraaditeatrist Eestis. Pikemalt peatutakse Ene-Liis Semperi ja Tiit Ojasoo lavastustel "Nafta", "No More Tears", "Julia" (aut. W. Shakespeare - T. Ojasoo) ja "Kuningas Ubu" (aut. A. Jarry)

  5. Stolitsa baltiskoi modõ / Vladimir Stroi

    Index Scriptorium Estoniae

    Stroi, Vladimir

    2005-01-01

    Riias toimunud Balti moenädalast (Baltic Fashion Week) ja seal näidatud kollektsioonidest. Eestit esindasid Ene (?Evelin) Lill kollektsiooniga "Puudutus" ja Kätlin Kängsepp "Muudatuste uued tuuled"

  6. Vaata inimest. Näe elu / Margit Tõnson

    Index Scriptorium Estoniae

    Tõnson, Margit, 1978-

    2011-01-01

    Teater NO99 lavastusest "The Rise and Fall of Estonia" Nokia Kontserdimajas. Idee, kontseptsioon ja lavastus Tiit Ojasoo ja Ene-Liis Semper. Viktor Pelevini "Kollane nool" Ugala teatris, lavastaja Mart Koldits

  7. Süütust näpates : Tanel Veenre fotoseeria teatrikostüümidest Draamateatri laval / Tanel Veenre, Hanna Tiidus, Margit Soosaar...[jt.

    Index Scriptorium Estoniae

    2007-01-01

    Stilist: Hanna Tiidus. Naine: Merle Palmiste. Poiss: Joonas (MJ-Models). Kostüümid etendustest "Rohuvoodi" (Aime Unt), "Rehepapp", "Tõeline inspektor koer" (Ene-Liis Semper), "Liilia" (Lilja Blumenfeld), "Mort" (Kersti Varrak), "Potilaadale" (Reet Aus), "Amadeus" (Krista Tool)

  8. Manifestically correct / Harry Liivrand

    Index Scriptorium Estoniae

    Liivrand, Harry, 1961-

    2000-01-01

    Euroopa kaasaegse kunsti biennaal Manifesta 3 Ljubljanas deviisi all "Piirijoone sündroom. Kaitsmise energiad". Eestit esindab Ene-Liis Semper videoinstallatsiooniga "FF / Rew". Aleksandr Breneri aktsioonist. Bosnia-Hersegoviina kunstniku Sejla Kamerici tööst jm

  9. Regional tectonic trends on the inner continental shelf off Konkan and central west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Ramana, M.V.

    Satellite imagery and offshore magnetic data were analysed to correlate regional tectonic elements on the inner continental shelf off Konkan and the adjacent Deccan plateau. Three statistically important lineament trends N-S, WNW-ESE and ENE...

  10. 2008. aastal keskenduti e-teenuste arendamisele : [2008. aasta rahvaraamatukogudes keskraamatukogude aruannete põhjal, tulevikuplaanides] / Meeli Veskus

    Index Scriptorium Estoniae

    Veskus, Meeli, 1953-

    2009-01-01

    Sisaldab ka: Raamatukogude kasutamine, lugejad ja kogud / Margit Jõgi. Lisa: Lugejateenindus ja kogud üldkasutatavates rahvaraamatukogudes 2008 : [joonised] / Margit Jõgi. Milline oli olukord rahvaraamatukogudes 2009. aasta algul? / Ene Riet.

  11. Raamatututvustus: lugemine kui mäng / Külliki Kask

    Index Scriptorium Estoniae

    Kask, Külliki, 1949-

    2009-01-01

    Tutvustus: Eco, Umberto. Kuus jalutuskäiku kirjandusmetsades / inglise keelest tõlkinud Ene-Reet Soovik. Tallinn : Varrak, 2009 ; Martin, George R. R. Windhaven / tõlkinud Jaana Talja. [Tartu] : Fantaasia, c2009

  12. Peaminister Juhan Parts ei plaani ametit maha panna / Juhan Parts ; interv. Toomas Sildam

    Index Scriptorium Estoniae

    Parts, Juhan, 1966-

    2004-01-01

    Peaminister Juhan Parts pooldab paremerakondade ühinemist, ei kavatse ametist lahkuda ning peab valitsuse üheks ülesandeks rahvaarutelu algatamist vabaduse samba üle. Lisa: Ene Ergma kõnest Riigikogus (13.09.2004)

  13. Pariis kui uus peatus inimese teekonnal / Katre Talviste

    Index Scriptorium Estoniae

    Talviste, Katre

    2003-01-01

    Karl Ristikivi "Inimese teekonna" tõlkest prantsuse keelde ("Chemin terrestre", tõlkija Tarah Montbélialtz, pseud, kirj. La Guillotine, Pariis, 2002). Ka Claude Merlini ja Ene Rämmeldi lavastusest "Inimese teekond"

  14. Алексий II 1929-2008

    Index Scriptorium Estoniae

    2008-01-01

    Aleksius II meenutavad: Kornelius, Tallinna ja kogu Eesti metropoliit ; Karin Jaani ; Marina Kaljurand ; Dmitri Medvedev, Venemaa president ; Helene Kamzol, Aleksius II sugulane ; Ain Seppik ; Vladimir Illjashevitsh ; Edgar Savisaar ; Jevgeni Tomberg ; Ene Ergma ; Toomas Hendrik Ilves, Eesti Vabariigi president

  15. Kas hakkas hirm võõrale maale ära kaduda? / Mööna Tilder

    Index Scriptorium Estoniae

    Tilder, Mööna

    2010-01-01

    Eike Ülevainu, Jaak Sapase ning Eneli Meresmaa lavastus "Estonia Meets Africa ehk Vaade eemalt", mis kannab tinglikult dokumentaallavastuse nime ja esitatakse nüüdistantsu ja -teatri vormis. Esietendus 9. dets. Tallinna Meistrite Hoovi teatrisaalis

  16. Tantsuline vaade kodusele Eestimaale Aafrikast / Tiiu Laks

    Index Scriptorium Estoniae

    Laks, Tiiu, 1984-

    2009-01-01

    9. dets. esietendub Tallinna Meistrite Hoovi teatrisaalis Eike Ülevainu, Jaak Sapase ning Eneli Meresmaa lavastus "Estonia Meets Africa ehk Vaade eemalt", mis kannab tinglikult dokumentaallavastuse nime ja esitatakse nüüdistantsu ja -teatri vormis

  17. Hoolimisega uimastite vastu

    Index Scriptorium Estoniae

    2011-01-01

    Vilniuses 15. aprillil 2011 toimunud heategevuskontserdist ja oksjonist rahvusvahelise uimastivastase ennetustööga tegeleva sihtasutuse Mentor Foundation toetuseks. Enampakkumisele pandi ka president Toomas Hendrik Ilvese ja Riigikogu spiikri Ene Ergma kirjutusvahendid

  18. Claisen, Cope and Related Rearrangements in the Synthesis of Flavour and Fragrance Compounds

    Directory of Open Access Journals (Sweden)

    Janusz Nowicki

    2000-08-01

    Full Text Available A review of the use of the Claisen, Cope and related [3,3]-sigmatropic rearrangements, sequential ("tandem" sigmatropic rearrangements and the "ene" reaction in the syntheses of flavour and fragrance compounds is presented.

  19. Kak prodat "Babushku" / Maria Melnikova ; interv. Galina Balashova

    Index Scriptorium Estoniae

    Melnikova, Maria

    2005-01-01

    Eesti Vene saatkonna "Vene galerii" osalemisest Madridis kunstilaadal ARCO-2005. Galerii esitles Ene-Liis Semperi videofilmi "Nimetu" ja vene kunstnike Bogdan Mamonovi ning Anton Litvini töid. Semperi ja Mamonovi töödest

  20. Reference: 84 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available enes in developing anthers was confirmed by RT-PCR and was consistent with a male... of an HMA2-green fluorescent protein fusion by confocal microscopy. These observations are consistent

  1. Research on Leadership, Motivation and Quality of Life in the Air Force Missile and Tanker Units

    Science.gov (United States)

    1977-06-01

    studying directly the results of applying different management principles in leading organizations. Enlight - ened management had demonstrated In... technologies for handling individual differences are fairly simple and straightforward. The demands placed upon analyses involving relationships and

  2. Steroids from marine sponges Suberites vestigium and Chrotella australiensis

    Digital Repository Service at National Institute of Oceanography (India)

    Mishra, P.D; Wahidullah, S.; De; Kamat, S.Y.

    The sponges Suberites vestigium and Chrotella australiensis have been examined for steriods. Both the sponges contain C sub(27-29) mono and diunsaturated sterols, in addition sponge C. australiensis contains cholest-4-ene-3-one and 24-ethyl cholest...

  3. NIR–FT Raman, FT–IR and surface-enhanced Raman scattering ...

    Indian Academy of Sciences (India)

    Administrator

    Single crystals of (S)-phenylsuccinic acid (SPSA) were grown by the slow evaporation tech- nique and vibrational ... the shift of Raman frequencies, enhancing or weak- ening of .... Harmonic vibrational wave numbers were cal- culated using ...

  4. Alleviation of osmotic stress of water and salt in germination and ...

    African Journals Online (AJOL)

    STORAGESEVER

    2008-07-04

    Jul 4, 2008 ... ening, osmoconditioning, osmohardening, and hormonal priming have ... germination, emergence and plant growth of wheat (Das and Choudhury .... In the present study, a significant three way interaction. (osmotic agents ...

  5. President viidi erilennukiga lennukikandjat uudistama / Katrin Rohtla

    Index Scriptorium Estoniae

    Rohtla, Katrin, 1966-

    2007-01-01

    President Toomas Hendrik Ilves lendas ameeriklaste organiseeritud lennuga Sitsiiliasse, et sealt sõita erilennuki pardal USA lennukikandjale USS Enterprise. Koos presidendiga käisid lennukikandjat uurimas Riigikogu esimees Ene Ergma ja Riigikogu liige Mati Raidma

  6. Otsustava teo päev / Tiit Maksim

    Index Scriptorium Estoniae

    Maksim, Tiit, 1941-

    2005-01-01

    Tallinnas Harjumäe nõlval avati Vabaduse monumendi alge - Võrumaalt Urvaste vallast toodud põllukivi, millesse on raiutud "Siia rajatakse vabaduse monument. 29. X 2005", osales ka parlamendiliige, spiiker Ene Ergma

  7. Halonen arrives for State visit / Ella Karapetyan

    Index Scriptorium Estoniae

    Karapetyan, Ella

    2010-01-01

    Eestis riigivisiidil viibinud Soome president Tarja Halonen kohtus peaminister Andrus Ansipi ja Riigikogu spiikri Ene Ergmaga. Presidendiga visiidil kaasas olnud Soome haridusminister Henna Virkkunen kohtus haridus- ja teadusminister Tõnis Lukasega

  8. Proof of the Structure of the Stemodia chilensis Tetracyclic Diterpenoid (+)-19-Acetoxystemodan-12-ol by Synthesis from (+)-Podocarpic Acid: X-ray Structure Determination of a Key Intermediate.

    Science.gov (United States)

    Leonelli, Francesca; Mostarda, Azzurra; De Angelis, Luca; Lamba, Doriano; Demitri, Nicola; La Bella, Angela; Ceccacci, Francesca; Migneco, Luisa M; Marini Bettolo, Rinaldo

    2016-04-22

    The first synthesis of (+)-19-acetoxystemodan-12-ol (1), a stemodane diterpenoid isolated from Stemodia chilensis, is described. The structure was supported by an X-ray crystallographic analysis of intermediate (+)-9a, which confirmed the proposed structure and excluded the structure of (-)-19-hydroxystemod-12-ene as a possible candidate for the Chilean Calceolaria diterpenoid to which the (-)-19-hydroxystemar-13-ene structure (9b) had been erroneously assigned.

  9. Transformations in the field of college education

    DEFF Research Database (Denmark)

    Bøje, Jakob Ditlev

    Paperet er kort version af den ene af mine analyser i ph.d.-projektet. Det drejer sig om en historisk diskursanalyse af transformationer af lærer- og pædagoguddnnnelse fra 60'erne til i dag.......Paperet er kort version af den ene af mine analyser i ph.d.-projektet. Det drejer sig om en historisk diskursanalyse af transformationer af lærer- og pædagoguddnnnelse fra 60'erne til i dag....

  10. Photo-initiated polymerisation of 1,8-octanedithiol and styrene

    International Nuclear Information System (INIS)

    Ang, J.B.; Hill, D.J.T.; Pomery, P.J.; Whittaker, A.K.

    1998-01-01

    Full text: Photo-initiated polymerisation of the thiol-ene system has been well investigated. Its applications include adhesives, coatings and opthalmic lenses. It is unlike the usual UV curable polymeric systems which are predominantly based on acrylates. Typically, acrylate systems are not strictly stoichiometric reactions. The thiol-ene process is a reactive composition based on the stoichiometric reaction of olefins (enes, acrylates) and thiols (mercaptans), which polymerise on exposure to UV light. A unique feature of the thiol-ene system is that the reaction is not inhibited by dissolved or ambient oxygen within the system, thereby eliminating the termination reaction which occurs in acrylate systems. The mechanism of the thiol-ene reaction is a step growth addition process which propagates by a free radical chain mechanism to yield the anti-Markovnikov product scheme. The majority of thiol-ene systems investigated focus on multifunctional moieties of thiol and olefin to produce highly cross-linked networks. This discussion will focus on kinetic information obtained from a linear system comprised of a disfunctional thiol (1,8-octanedithiol) and styrene initiated by a UV light source

  11. catena-Poly[[{bis­[tetra­aqua­(2-hy­droxy-3,4-dioxocyclo­but-1-en-1-olato-κO 1)bariumstrontium(0.35/0.65)]di-μ-aqua}­bis­(μ-2-hy­droxy-4-oxocyclo­but-1-ene-1,3-diolato-κ2 O 1:O 3)] monohydrate

    OpenAIRE

    Trifa, Chahrazed; Bouhali, Amira; Bouacida, Sofiane; Boudaren, Chaouki; Bataille, Thierry

    2011-01-01

    International audience; The title structure, {[Ba(0.71)Sr(1.29)(C(4)HO(4))(4)(H(2)O)(10)]*H(2)O}(n), is built from dimers of edge-sharing monocapped square anti-prisms [(Ba/Sr)O(3)(H(2)O)(6)], in which barium and strontium are statistically disordered [ratio 0.353 (8):0.647 (8)] on the same crystallographic site. Such dimers are connected via bidentate hydrogen squarate groups [HC(4)O(4)](-), leading to chains that propagate along the b axis. Inter- and intra-molecular O-H⋯O hydrogen bonds ma...

  12. Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer.

    Directory of Open Access Journals (Sweden)

    Sura Aziz

    Full Text Available Presence of lymph node (LN metastasis is a strong prognostic factor in breast cancer, whereas the importance of extra-nodal extension and other nodal tumor features have not yet been fully recognized. Here, we examined microscopic features of lymph node metastases and their prognostic value in a population-based cohort of node positive breast cancer (n = 218, as part of the prospective Norwegian Breast Cancer Screening Program NBCSP (1996-2009. Sections were reviewed for the largest metastatic tumor diameter (TD-MET, nodal afferent and efferent vascular invasion (AVI and EVI, extra-nodal extension (ENE, number of ENE foci, as well as circumferential (CD-ENE and perpendicular (PD-ENE diameter of extra-nodal growth. Number of positive lymph nodes, EVI, and PD-ENE were significantly increased with larger primary tumor (PT diameter. Univariate survival analysis showed that several features of nodal metastases were associated with disease-free (DFS or breast cancer specific survival (BCSS. Multivariate analysis demonstrated an independent prognostic value of PD-ENE (with 3 mm as cut-off value in predicting DFS and BCSS, along with number of positive nodes and histologic grade of the primary tumor (for DFS: P = 0.01, P = 0.02, P = 0.01, respectively; for BCSS: P = 0.02, P = 0.008, P = 0.02, respectively. To conclude, the extent of ENE by its perpendicular diameter was independently prognostic and should be considered in line with nodal tumor burden in treatment decisions of node positive breast cancer.

  13. GC-MS study of Nigella sativa (seeds fatty oil

    Directory of Open Access Journals (Sweden)

    Mehta, B. K.

    2002-06-01

    Full Text Available The GC-MS study of N. sativa (seeds fatty oil revealed the presence of 26 compounds which were identified as methyl hept-6-enoate,1-phenylhepta-2,4-dione, pentadecane, hexadec-1-ene, 1-phenyldecan-2-one, octadec-1-ene, octadecane, methyl pentadecanoate, bis(3-chlorophenyl ketone, diethyl phthalate, ethyl octadec-7-enoate, methyl octadecanoate, tricos-9-ene, octadeca-9,12-dienoic acid, hexadecanoic acid, methyl hexadecanoate, methyl octadec-15-enoate, henicosan-10-one, 2-methyl octadecanoic acid, docos-1-ene, ethyl octadecanoate, methyl octadecanoate, pentacos-5-ene,12-methyltricosane, dibutyl phthalate and 2-methyltetracosane.El estudio por GC-MS del aceite de la semilla de Nigella sativa reveló la presencia de 26 compuestos los cuales fueron identificados como: hept-6-enoato de metilo, 1-fenilhepta-2,4-diona, pentadecano, hexadec-1-eno, 1-fenildecan-2-ona, octadec-1-eno, octadecano, pentadecanoato de metilo, bis(3-clorofenil cetona, ftalato de dietilo, octadec-7-enoato de etilo, octadecanoato de metilo, tricos-9-eno, ácido octadeca-9,12-dienoico, ácido hexadecanoico, hexadecanoato de metilo, octadec-15-enoato de metilo, henicosan-10-ona, ácido 2-metil octadecanoico, docos-1-eno, octadecanoato de etilo, octadecanoato de metilo, pentacos-5-eno, 12-metiltricosano, ftalato de dibutilo y 2-metiltetracosano.

  14. Chemical constituents from Aspidosperma illustre (Apocynaceae)

    International Nuclear Information System (INIS)

    Barbosa, Lara F.; Mathias, Leda; Braz-Filho, Raimundo; Vieira, Ivo J. Curcino

    2010-01-01

    A new natural product oleanane-type triterpene, olean-12-ene-11α-methoxy-3β-acetate (10) was isolated from Aspidosperma illustre, together with β-amyrin (3), lupeol (4), β-amyrin acetate (5), lupeol acetate (6), olean-12-ene-28-hydroxy-3α-tetradecanoate (7), olean-12-ene-28-carboxy-3α-hexadecanoate (8), ursolic acid (9) triterpenes, and two monoterpenic indole alkaloids, b-yoimbine (1) and 1,2-dehydroaspidospermidine (2). These compounds were characterized on their spectral data basis, mainly one- ( 1 H, 13 C, APT) and two-dimensional ( 1 H- 1 H-COSY, 1 H- 1 HNOESY, HMQC and HMBC) NMR, and mass spectra, involving also comparison with data from the literature. (author)

  15. Three new triterpene esters from pumpkin (Cucurbita maxima) seeds.

    Science.gov (United States)

    Kikuchi, Takashi; Ueda, Shinsuke; Kanazawa, Jokaku; Naoe, Hiroki; Yamada, Takeshi; Tanaka, Reiko

    2014-04-16

    Three new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2), and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3), were isolated from seeds of Cucurbita maxima, along with the known compound, multiflora-7,9(11)-diene-3α,29-diol 3,29-dibenzoate (4). Compound 1 exhibited melanogenesis inhibitory activities comparable with those of arbutin. In cytotoxicity assays, compounds 1 and 3 exhibited weak cytotoxicity, with IC50 values of 34.5-93.7 μM against HL-60 and P388 cells.

  16. Three New Triterpene Esters from Pumpkin (Cucurbita maxima Seeds

    Directory of Open Access Journals (Sweden)

    Takashi Kikuchi

    2014-04-01

    Full Text Available Three new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1, 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2, and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3, were isolated from seeds of Cucurbita maxima, along with the known compound, multiflora-7,9(11-diene-3α,29-diol 3,29-dibenzoate (4. Compound 1 exhibited melanogenesis inhibitory activities comparable with those of arbutin. In cytotoxicity assays, compounds 1 and 3 exhibited weak cytotoxicity, with IC50 values of 34.5–93.7 μM against HL-60 and P388 cells.

  17. The in vitro biosynthesis of epitestosterone and testosterone from C19 steroid precursors in the testis of the lizard Tiliqua rugosa

    International Nuclear Information System (INIS)

    Huf, P.A.; Bourne, A.R.; Watson, T.G.

    1989-01-01

    The metabolism of androgens in the testis of the lizard Tiliqua rugosa has been studied in vitro by incubating cellular homogenates with radiolabeled C19-steroid substrates. The identification 17 beta-oxidoreductase and 3 beta-hydroxysteroid dehydrogenase/isomerase activities. Aromatase, 5 alpha-reductase, and 17 alpha/beta-epimerase activities were not detected. The 17 alpha-oxidoreductase activity was temperature dependent (maximal at 32 degrees), while the 17 beta-oxidoreductase activity was temperature independent. Time yield and dual-label studies indicated that testosterone biosynthesis mainly involves the 4-ene pathway (via androstenedione), whereas the formation of epitestosterone uses both the 4-ene and 5-ene (via 5-androstene-3 beta, 17 alpha-diol) pathways. The function of alternative pathways in androgen biosynthesis is discussed, as is the role of temperature in the intratesticular regulation of androgen production

  18. Synthesis, characterization and anticancer studies of new steroidal oxadiazole, pyrrole and pyrazole derivatives

    Directory of Open Access Journals (Sweden)

    Shamsuzzaman

    2015-07-01

    Full Text Available In the present study steroidal derivatives, 3β-[5′-mercapto-1′,3′,4′-oxadiazole-2-yl]methoxy cholest-5-ene 2, 3β-[2′,5′-dimethylpyrrole-1-yl]aminocarbonylmethoxycholest-5-ene 3 and 3β-[3′,5′-dimethyl pyrazole-1-yl]carbonylmethoxycholest-5-ene 4 have been synthesized from cholest-5-en-3β-O-acetyl hydrazide 1 using CS2/KOH, acetonyl acetone and acetyl acetone, respectively as reagents and are characterized by IR, 1H NMR,13C NMR, MS and elemental analysis. Compounds 2–4 were also evaluated for anticancer activity against human leukemia cell line (HL-60 by MTT assay and compound 4 displayed the promising behavior by showing better anticancer activity.

  19. Estudo fitoquímico da madeira de Guarea macrophylla (Meliaceae Phytochemical study of the wood from Guarea macrophylla (Meliaceae

    Directory of Open Access Journals (Sweden)

    João Henrique G. Lago

    2009-01-01

    Full Text Available In the present work, the crude ethanol extract from wood of G. macrophylla was submitted to liquid/liquid partition between hexane, CH2Cl2, EtOAc and n-BuOH. Each phase was individually chromatographed over silica gel, Sephadex LH-20 or Amberlite XAD-2 to give eight terpene derivatives, such as five sesquiterpenoids (caryophyllene oxide, guai-6-en-10β-ol, spathulenol, aromadendrane-4β,10α-diol and aloaromadendrane-4α,10β-diol as well as three triterpenoids (cicloart-24-ene-3β,23(R*-diol, cicloart-24-ene-3β,23(S*-diol, and cicloart-23E-ene-3β,25-diol. Additionally, were isolated three fatty acids (linolenic, linoleic and stearic, two steroids (sitosterol and stigmasterol and sacarose. The structures of all these compounds were characterized by spectrometric analysis, mainly mass spectrometry and NMR and comparison of these data described in the literature.

  20. Chemical Constituents from Bombacopsis glabra (Pasq. A. Robyns: Complete 1H and 13C NMR Assignments and X Ray Structure of 5-Hydroxy-3,6,7,8,4'-pentamethoxyflavone

    Directory of Open Access Journals (Sweden)

    Paula Vanderlúcia F.

    2002-01-01

    Full Text Available The flavone 5-hydroxy-3,6,7,8,4'-pentamethoxyflavone (1 and the triterpenes lupenone, 9,19-cyclolanost-23-ene-3beta,25-diol (2, (24R-9,19-cyclolanost-25-ene-3beta,24-diol (3 and (24S-9,19-cyclolanost-25-ene-3beta,24-diol (4 were isolated from the hexane extract of the stem bark of Bombacopsis glabra (Bombacaceae. The structures were determined by 13C and ¹H NMR (1D and 2D and mass spectrometry, and by comparison with literature data for triterpenes. The structure of the flavone 1 was unambiguously confirmed by a X-ray diffraction study. The five substances were isolated for the first time from Bombacaceae species.

  1. Senior High School English National Examination and Thinking Skills

    Directory of Open Access Journals (Sweden)

    Ummu Lathifah Ahmad

    2016-12-01

    Full Text Available When English National Examination (abbreviated into ENE as a norm-referenced test is designed for instructional purposes, to evaluate the result of national curriculum, it is very significant to conduct item test evaluation since it gives a clear portrait of the quality of the items and of the test as a whole. The purpose of this study was to analyze which levels of the Barrett taxonomy were more reflected in ENE items of 2013/2014 academic year and whether the proportions of items among the twenty test packages in the ENE assessing students’ Lower Order Thinking Skills (LOTS and Higher Order Thinking Skills (HOTS are consistent. The researcher adopted the qualitative descriptive approach using a content analysis card to codify the ENE items. To ensure the reliability of the study, three inter-raters analyzed a sample of the test packages. The results indicated that questions asking LOTS still prevailed in ENE items. Of all the twenty test packages, the items categorized into literal level represented around 68.6% of the total number of the questions. Meanwhile, the questions belonging to reorganization came to occupy a percentage of 20.8 and the questions asking the students’ inferential level only reached 10.3%. Also, the tests were not enriched sufficiently with the evaluation comprehension since they only comprised 0.3%. The results also showed the complete absence of “Appreciation” – the highest level of thinking in the mentioned taxonomy. It is obvious that there is a shortage of items questioning students’ HOTS in the exam and they are not well-treated. Accordingly, this finding reveals that there is still much room for ENE to be the driving force in the effort to make learners critical thinkers. In the light of these data, this study recommends modifying the English National Exam by providing them with more question items that include HOTS.

  2. Teatri aastaauhindade nominendid

    Index Scriptorium Estoniae

    2006-01-01

    Lavastajaauhind : Merle Karusoo, Elmo Nüganen, Tiit Ojasoo, Ene-Liis Semper, Kristian Smeds, Hendrik Toompere jun, Ingomar Vihmar ; kunstnikuauhind : Iir Hermeliin, Liina Keevallik, Ene-Liis Semper, Aime Unt, Ervin Õunapuu ; naisnäitleja auhind : Ülle Kaljuste, Kaie Mihkelson, Harriet Toompere, Marika Vaarik, Liina Vahtrik ; meesnäitleja auhind : Ain Lutsepp, Rein Oja, Rain Simmul, Tarvo Sõmer, Tambet Tuisk, Aarne Üksküla ; Balleti- ja tantsuteater : Marina Tshirkova, Seki Hirotaka, Mari Savitski, Oksana Titova, Taavet Jansen, Sasha Pepeljajev, Katrin Essenson ja Tantsuteater Fine 5

  3. Agripinin portret u odnosu prema rimskim ženskim portretima s pulskog i nezakcijskog agera

    OpenAIRE

    Girardi Jurkić, Vesna; Džin, Kristina

    2006-01-01

    Za vrijeme zaštitnog arheološkog istraživanja (1987.-1988.) na forumu u Puli (Colonia Pola)otkrivena je mramorna ženska glava za koju se pretpostavlja da je portret Agripine Mlađe, ženecara Klaudija i majke cara Nerona. Skulptura je originalno vjerojatno bila postavljena na zidanojbazi u sjeveroistočnom zidu luksuzne prostorije popločene mramorom i ukrašene štukaturama nazidu kojega je baza bila ukrašena mramorom i štukom. Tri natpisa otkrivena u blizini tzv. Agripininekuće spominju careve Kl...

  4. Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima Seeds

    Directory of Open Access Journals (Sweden)

    Reiko Tanaka

    2013-05-01

    Full Text Available Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1, 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2, and multiflora-7,9(11-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3, were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11-diene-3a-29-diol 3-benzoate (5 exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells.

  5. Three new multiflorane-type triterpenes from pumpkin (Cucurbita maxima) seeds.

    Science.gov (United States)

    Kikuchi, Takashi; Takebayashi, Mika; Shinto, Mayumi; Yamada, Takeshi; Tanaka, Reiko

    2013-05-14

    Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)-diene-3a-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells.

  6. Thermal rearrangement of 7-methylbicyclo

    Science.gov (United States)

    Bender; Leber; Lirio; Smith

    2000-08-25

    The gas-phase thermal rearrangement of exo-7-methylbicyclo[3.2.0]hept-2-ene yields almost exclusively 5-methylnorbornene products. Inversion (i) of configuration dominates this [1,3] sigmatropic shift although some retention (r) is also observed. Because the [1,3] migration can only occur suprafacially (s) in this geometrically constrained system, the si/sr ratio of 7 observed for the migration of C7 in exo-7-methylbicyclo[3.2.0]hept-2-ene indicates that the orbital symmetry rules are somewhat permissive for the [1,3] sigmatropic migration of carbon.

  7. Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells.

    OpenAIRE

    Pegg, A E; Nagarajan, S; Naficy, S; Ganem, B

    1991-01-01

    Synthetic unsaturated analogues of the natural polyamine were examined as possible substrates for spermine synthase and as replacements for spermidine in supporting the growth of SV-3T3 cells. It was found that N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene [the cis isomer of the alkene analogue of spermidine] was a good substrate for spermine synthase, but that the trans isomer [N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene] and the alkene analogue [N-(3-aminopropyl)-1,4-diaminobut-2-yne] were ...

  8. Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of antiproliferative effects in vitro.

    Science.gov (United States)

    Vessières, Anne; Top, Siden; Pigeon, Pascal; Hillard, Elizabeth; Boubeker, Leila; Spera, Daniela; Jaouen, Gérard

    2005-06-16

    We report here the synthesis and the strong and unexpected antiproliferative effect of the organometallic diphenolic compound 1,1-bis(4'-hydroxyphenyl)-2-ferrocenyl-but-1-ene (4) on both hormone-dependent (MCF7) and -independent (MDA-MB231) breast cancer cells (IC(50) = 0.7 and 0.6 microM). Surprisingly, 6 [1,2-bis(4'-hydroxyphenyl)-2-ferrocenyl-but-1-ene], the regioisomer of 4, shows only a modest effect on these cell lines. This pertinent organometallic modification seems to trigger an intracellular oxidation of the structurally favorable compound 4, leading to the generation of a potent cytotoxic compound.

  9. Uloga radnog terapeuta u rehabilitaciji oboljelih od šizofrenije

    OpenAIRE

    Radić, Saša; Škrbina, Dijana

    2011-01-01

    Mentalno zdravlje je esencijalni čimbenik za aktivno i neovisno funkcioniranje u svim aspektima života. Poremećaji mentalnog zdravlja značajno narušavaju svakodnevno življenje, te uzrokuju disbalans u tri područja čovjekovih aktivnosti: samozbrinjavanju, produktivnosti i slobodnom vremenu. Odabir, organiziranje i aktivna participacija u produktivnim aktivnostima pojedinca narušenog mentalnoga zdravlja značajno su ograničene i/ili onemogućene zbog smanjene motivacije, nemogućnosti zadovo...

  10. Synthesis, antimicrobial and cytotoxicity evaluation of new cholesterol congeners

    Directory of Open Access Journals (Sweden)

    Mohamed Ramadan El Sayed Aly

    2015-10-01

    Full Text Available 3β-Azidocholest-5-ene (3 and (3β-3-(prop-2-yn-1-yloxycholest-5-ene (10 were prepared as substrates to synthesize a variety of three-motif pharmacophoric conjugates through CuAAC. Basically, these conjugates included cholesterol and 1,2,3-triazole moieties, while the third, the pharmacophore, was either a chalcone, a lipophilic residue or a carbohydrate tag. These compounds were successfully prepared in good yields and characterized by NMR, MS and IR spectroscopic techniques. Chalcone conjugate 6c showed the best antimicrobial activity, while the lactoside conjugate 27 showed the best cytotoxic effect in vitro.

  11. EEG POLISOMNOGRAFIJA KAO ZNAČAJNA DIJAGNOSTIČKA I PROGNOSTIČKA METODA ZA PROCJENU OŠTEĆENJA MOZGA U NOVOROĐENČADI I DOJENČADI

    OpenAIRE

    Paškov Dugandžija, Gordana

    2008-01-01

    EEG polisomnografija je značajna metoda za dijagnozu i prognozu oštećenja mozga u nedonošene i donošene novorođenčadi i dojenčadi. Sadrži slijedeće elemente: EEG(elektroencefalografija), EOG( elektrookulografija) , EMG( elektromiografija), EKG (elektrokardiografija), respiracija i video monitoriranje. Primjenjujemo polisomnografsku montažu. To je specifično modificiran način postavljanja elektroda. Koristimo posrebrene pločaste elektrode sa 1 metar savitljivim silikonskim odvodima u šest razl...

  12. Gender stereotypes analysis in cartoons broadcasted on Croatian televisions

    OpenAIRE

    Rudančić, Vlatka

    2015-01-01

    Rodni stereotipi postoje od kada postoje muškarci i žene, njihovo značenje roda i spola. Od samih početaka razvoja pismenosti (od doba Aristotela) muškarci su bili oni koji su išli u lov i čije se mišljenje uvažavalo, dok su žene ostajale doma, rađale djecu i brinule se o njima. Istraživanje se temelji na osamdeset analiziranih crtanih filmova koji se prikazuju na hrvatskim nacionalnim TV postajama te prikazuju postojanje rodnih stereotipa u svim pregledanim materijalima. Metoda koja se koris...

  13. POTENCIJALI PRIMJENE INTEGRIRANIH SUSTAVA UPRAVLJANJA U NAFTNOJ INDUSTRIJI

    OpenAIRE

    Lulić, Lukša

    2014-01-01

    S obzirom na svoje posebnosti, određene industrije i sektori moraju posjedovati specifične i rigorozne sustave upravljanja te su u skladu s takvim zahtjevima razvile industrijski specifične zahtjeve i standarde. Razlozi takvih aktivnosti uključuju upravljanje rizicima, spoznaju specifičnih zahtjeva određene industrije, sukladnost sa zakonskim i regulatornim zahtjevima te jačanje povjerenja u proizvode i procese dobavljača. Nafta je polivalentni energent, a naftna industrija podrazumijeva m...

  14. Terpenoid constituents from leaves of Guarea kunthiana

    International Nuclear Information System (INIS)

    Garcez, Fernanda R.; Garcez, Walmir S.; Bazzo, Rita de Cassia; Silva, Ana Francisca G. da; Resende, Ubirazilda M.

    2004-01-01

    From leaves of Guarea kunthiana one new kaurene diterpene (ent-kaur-16-en-2-one) was isolated along with eight known diterpenes (ent-kaur-16-ene, ent-3α- and 3β-hydroxykaur-16-ene, kolavelool, kolavenol, kolavenal, ent-13-epi-manoyloxide and (-)-nephthenol), four sesquiterpenes (alismol, alismoxide, spathulenol and 4β,10α-aromadendranediol), polyprenol-12 and α- and δ-tocopherols. Kolavenal is reported for the first time as a natural product, as well as the occurrence of cembrane- and ent-kaurane-type diterpenes in the Meliaceae. (author)

  15. Teatri aastaauhindadele kandideerijad selgunud

    Index Scriptorium Estoniae

    2006-01-01

    Lavastajaauhind : Merle Karusoo, Elmo Nüganen, Tiit Ojasoo, Ene-Liis Semper, Kristian Smeds, Hendrik Toompere jun, Ingomar Vihmar ; kunstnikuauhind : Iir Hermeliin, Liina Keevallik, Ene-Liis Semper, Aime Unt, Ervin Õunapuu ; naisnäitleja auhind : Ülle Kaljuste, Kaie Mihkelson, Harriet Toompere, Marika Vaarik, Liina Vahtrik ; meesnäitleja auhind : Ain Lutsepp, Rein Oja, Rain Simmul, Tarvo Sõmer, Tambet Tuisk, Aarne Üksküla ; Balleti- ja tantsuteater : Marina Tshirkova, Seki Hirotaka, Mari Savitski, Oksana Titova, Taavet Jansen, Sasha Pepeljajev, Katrin Essenson ja Tantsuteater Fine 5

  16. Antiproliferative Compounds of Cyphostemma greveana from a Madagascar Dry Forest[1

    OpenAIRE

    Cao, Shugeng; Hou, Yanpeng; Brodie, Peggy; Miller, James S.; Randrianaivo, Richard; Rakotobe, Etienne; Rasamison, Vincent E.; Kingston, David G. I.

    2011-01-01

    Bioassay-guided fractionation of the EtOH extracts obtained from a plant identified as Cyphostemma greveana Desc. (Vitaceae) led to the identification of one macrolide, lasiodiplodin (1), three sesquiterpenoids, 12-hydroxy-15-oxo-selina-4,1l-diene (2), 1β,6α-dihydroxyeudesm-4(15)-ene (3), and (7R*)-opposit-4(15)-ene-1β,7-diol (5), and the new diterpenoid, 16,18-dihydroxykolavenic acid lactone (4). All the isolates were tested against the A2780 human ovarian cancer cell line, and compound 4 an...

  17. Two new cucurbitane triterpenoids from the seeds of Momordica charantia.

    Science.gov (United States)

    Ma, Lin; Yu, Ai-Hua; Sun, Li-Li; Gao, Wan; Zhang, Meng-Meng; Su, Ya-Lun; Liu, Hua; Ji, Teng-Fei; Li, Di-Zao

    2014-01-01

    Two new cucurbitane triterpenoids 1 and 2 were isolated, together with six known compounds, from the seeds of Momordica charantia L. The structures of new compounds were determined to be 3-O-{[β-d-galactopyranosyl(1 → 6)]-O-β-d-galactopyranosyl}-23(R), 24(R), 25-trihydroxycucur-bit-5-ene (1), 3-O-[β-d-galactopyranosyl]-25-O-β-d-galactopyranosyl-7(R), 22(S), 23(R), 24(R), 25-pentahydroxycucurbit-5-ene (2), respectively. Their structures were elucidated by the combination of mass spectrometry, one- and two-dimensional NMR experiments and chemical reactions.

  18. Suvine Tallinn on täis head tarbekunsti, ka harrastajad on aktiivsed / Andri Ksenofontov

    Index Scriptorium Estoniae

    Ksenofontov, Andri, 1962-

    2005-01-01

    Andres ja Katja Koorti korraldatud kobarnäitus "18 tuba" Sakala t. 9 majas, Adolfas Shaulyse ja Mari Relo-Shaulyse näitus "Viva la vida!" A-galeriis, Piret Räni näitus "Hello friend - are you impotent?" EKA galeriis, Tiina Piisangu tööd köitekunstinäitusel "Scripta manent III. Maailma parim asi" Eesti Tarbekunsti- ja Disainimuuseumis, Kristiina Kalistru ja Silvia Kelle tööd Kullo galeriis, Anne Türni tööd ja väljapanek Lühikese jala galeriis, Eesti Keraamikute Liidu puupõletustehnikas teostatud tööde näitus arhitektuurimuuseumis, Thomas Häntzscheli fotode näitus ArtDepoos, Angelika Kauffmanni näitus Kadrioru Kunstimuuseumis, Adam Greeni ja Simona Dell'Agli näitus "Tekkimine" Tallinna Linnagaleriis, Merike Estna maalinäitus "The Sexiest Girl, Pussycat, the Happiest Girl and Two Loverabbits" Haus galeriis, Monica del Norte maalinäitus "Lugupilt" G-galeriis, Päivi Randveri näitus "Reisid kosmosesse" Draakoni galeriis, Kelli Valk Kagovere näitus "Kõik muutub" Ühispanga galeriis, Toomas Sarapuu näitus "Deebetkaart" Tallinna Kunstihoone galeriis jm.

  19. Galeriid - Tallinna kunstisoonel / Andri Ksenofontov

    Index Scriptorium Estoniae

    Ksenofontov, Andri, 1962-

    2005-01-01

    Valgusfestival Tallinnas, Angelika Schneideri joonistuste näitus "Valgest mustani" Estonia Kontserdisaali fuajees, Liina Vedleri näitus "Raskolnikova saar" EKA galeriis, Maria Valdma näitus "Fiktsioonid" Tallinna Linnagaleriis, Eveli Variku näitus "Armuke" Kunstihoone galeriis, Tarmo Roosimöldri näitus "Paus" ning Kaarina Ormio, Jaan Pärnamäe ja Elin T. Sorenseni installatsioon "Mäng" G-galeriis, šveitsi-soome fotograafi Peter Strebeli näitus "Maroko Anti-Atlase mäestiku motiivid" Kiek in de Kökis, Jaan Künnapi Tallinna panoraam näitusel "Tallinn, inimesed ja linn 1878-2002" Raevangla Fotomuuseumis, TPÜ üliõpilaste fotonäitus "Fotofinish" fotokeldris Lee, TPÜ kunstiosakonna üliõpilaste näitus "Tehnika ja lüürika" Viviann Napa galeriis, näitus "Juugendstiil Lätis", Pille Kivihalli, Maarja Unduski ja Tiina Piisangu näitus "Altar raamatule" rahvusraamatukogus, Toomas Keldri mälestusnäitus disaini- ja arhitektuurigaleriis, Irina Ishina näitus Vene saatkonna galeriis, Vladimir Baciu näitus Haus galeriis, Vassili Gretshko näitus Artline'i galeriis, Jana Wiebe ja Tjika Rebase "Surnuaia kogumik vol. 1" Hobusepea galeriis, Kadi Kurema näitus "Imeasjad" Ühispanga galeriis ja "Pisiasjad" Galeriis 36

  20. Sleep characteristics, sleep problems, and associations of self-efficacy among German university students

    Directory of Open Access Journals (Sweden)

    Gulewitsch MD

    2012-02-01

    Full Text Available Angelika A Schlarb1,2, Dominika Kulessa1,*, Marco D Gulewitsch1,*1Faculty of Science, Department of Psychology, University of Tübingen, 2Faculty of Psychology, University of Koblenz-Landau, Germany*These authors contributed equally to this workBackground: Sleep problems, especially insomnia, are a common complaint among adults. International studies on university students have shown prevalence rates between 4.7% and 36.2% for sleep difficulties, and 13.1% and 28.1% for insomnia. Sleep problems are associated with lower social and academic performance and can have a severe impact on psychological and physical health.Objective: The goal of this study was to outline sleep characteristics, prevalence of sleep problems, insomnia, and associations with self-efficacy among German university students.Methods: A total of 2196 university students (70.9% women; mean age 24.16 years participated in the study. Sleep characteristics, sleep problems, insomnia, and self-efficacy were assessed using a questionnaire.Results and conclusion: Analyses revealed that more than 16% of surveyed students needed more than 30 minutes to fall asleep. About 7.7% of the students suffered from insomnia. Short sleep was significantly associated with a considerably increased rate of insomnia (20%. Insomniacs showed lower self-efficacy than students without sleep problems.Keywords: university students, sleep characteristics, sleep problems, insomnia, self-efficacy

  1. Protestibiennaal kunsti suukorvistamise vastu / Margit Tõnson

    Index Scriptorium Estoniae

    Tõnson, Margit, 1978-

    2006-01-01

    Tšetšeenia toetuseks organiseeritud rahvusvahelisest rändnäitusest "Emergency Biennale" Tallinna Kunstihoones, kuraator Evelyne Jouanno. Kaasaegse Kunsti Eesti Keskuse korraldatud ettekandepäevast "Kunstniku moraalsed valikud liberaalse demokraatia ja islami kokkupõrgetes", kus esinevad Margit Sutrop, Johannes Saar, Marek Järvik, Ene-Liis Semper, Eero Epner

  2. Rein Raua kuraatoridebüüt

    Index Scriptorium Estoniae

    2001-01-01

    Hausi galeriis Rein Raua kureeritud rahvusvaheline kunstinäitus "KevadSuviSügisTalv. Murdumispunkt". Esinevad Eve Kask, Peeter Laurits, Dainius Lickevicius, Rehka Menon, Mall Nukke, Herkki Merila, Jorma Puranen, Rosita Raud, Ene-Liis Semper, Liina Siib, S. ja P. Stanikas

  3. Raud kureerib kunstnikke

    Index Scriptorium Estoniae

    2001-01-01

    21. dets.-12. jaan. on on Haus galeriis Rein Raua kuraatoriprojekt "KevadSuviSügisTalv. Murdumispunkt". Näitusel osalevad Eve Kask, Peeter Laurits, Dainius Lishkevicius (Leedu), Rekha Menon (India/USA), Mall Nukke, Herkki Merila, Jorma Puranen (Soome), Rosita Raud, Ene-Liis Semper, Liina Siib, S&P Stanikas (Leedu)

  4. Synthesis, Characterization and Application of Thermoresponsive Polyhydroxyalkanoate-graft-Poly(N-isopropylacrylamide)

    DEFF Research Database (Denmark)

    Ma, Yi-Ming; Wei, Dai-Xu; Yao, Hui

    2016-01-01

    (3HDD-co-3H10U), a random copolymer of 3-hydroxydodecanoate (3HDD) and 3-hydroxy-10-undecylenate (3H10U), via a thiol–ene click reaction. Enhanced hydrophilicity and thermoresponsive property of the resulted PHA-g-PNIPAm were confirmed by water contact angle studies. The biocompatibility of PHA...

  5. Ajatu Ita Ever pühendab end jäägitult teatrile / Rein Veidemann

    Index Scriptorium Estoniae

    Veidemann, Rein, 1946-

    2006-01-01

    Näitleja Ita Everi 75. sünnipäeva puhul. Arvamust tema kohta avaldavad ka näitlejad Aleksander Eelmaa, Rasmus Kaljujärv, Tiit Sukk, teatrikunstnikud Ene-Liis Semper ja Aime Unt, teatrinõunik Tõnu Lensment

  6. Smagsoplevelse og Fordybelse

    DEFF Research Database (Denmark)

    Brodersen, Peter

    2017-01-01

    Smag og smagsoplevelser har en selvstændig plads i faget madkundskab, og som sådan er de sigtekorn for dannelsesforestillinger. Med afsæt i teorien om kategorial dannelse drøfter kapitlet, hvordan fordybelse gennem sansebaserede og æstetiske smagsoplevelser på den ene side og analytiske aktivitet...

  7. Teacher evaluation through observation : Application of classroom observation and student ratings to improve teaching effectiveness in classrooms

    NARCIS (Netherlands)

    van der Lans, Rikkert

    2017-01-01

    De ene les is de andere niet Meer en meer scholen voeren jaarlijks gesprekken met hun leraren over de kwaliteit van hun lessen. Deze evaluatiegesprekken zijn, als het goed is, gebaseerd op lesbezoeken. Vaak brengt alléén een teamleider één hooguit twee keer per jaar een lesbezoek aan de leraren. Dat

  8. Kriitika allikakaitse eelnõule

    Index Scriptorium Estoniae

    2010-01-01

    Rahvusvahelised ajakirjandusorganisatsioonid pöördusid allikakaitse seaduse eelnõu asjus president Toomas Hendrik Ilvese poole ja väljendasid muret, et eelnõu ohustab ajakirjandusvabadust Eestis. Kirja koopia saadeti ka Riigikogu esimehele Ene Ergmale, justiitsminister Rein Langile, Euroopa Komisjoni asepresidendile Viviane Redingile ja Euroopa Parlamendi inimõiguste komitee esimehele Heidi Hautalale

  9. Veneetsia kuldlõvid jagatud

    Index Scriptorium Estoniae

    2001-01-01

    Veneetsia biennaali Kuldlõvid elutöö eest - Richard Serra ja Cy Twombly. Paviljoni preemia läks Saksa paviljonile ja Gregor Schneiderile ruumisimulatsiooni eest. Eriauhinnad: Janet Cardiff, George Bures Miller, Marisa Merz, Pierre Huyghe. Premeeritud noored kunstnikud (4), esiletõstetud kunstnikud (4) jm. Ene-Liis Semperi ja Marko Laimre väljapanekust.

  10. Making ends meet. A synthesis of research on consumer behaviour and the environment

    DEFF Research Database (Denmark)

    Thøgersen, John

    1999-01-01

    litteratur. Især to diskussioner er mere udfoldede i denne sammenfatning end noget andet sted i disputatsen. Den ene er diskussionen om, hvordan mit teoretiske bidrag adskiller sig fra markante forgængere, især Icek Ajzens Theory of Planned Behaviour. Den anden er diskussionen af mine analysers...

  11. Universitetets forandring

    DEFF Research Database (Denmark)

    Elle, Birgitte

    2016-01-01

    den mest demokratiske universitetsstyrelseslov fra 1970/73 så dagens lys, har været ”samfundets krav og kontrol”, som er slået igennem i de efterfølgende universitetslove. Artiklen viser desuden, hvordan øgede krav om international konkurrenceevne på den ene side og uomgængelig kontraktstyring af...

  12. E-bogen - revolution eller ej?

    DEFF Research Database (Denmark)

    Albrechtsen, Charlotte; Jensen, Tine Wirenfeldt

    2002-01-01

    På baggrund af en sammenligning mellem på den ene side transitionen fra trykte til digitale medier og på den anden side overgangen fra håndskrift til print midt i 1500-tallet argumenteres der for at e-bogen kan betragtes som en moderne version af inkunablen....

  13. Eesti kirjandus on suurem kui paistab / Pille-Riin Larm

    Index Scriptorium Estoniae

    Larm, Pille-Riin, 1981-

    2015-01-01

    Tartu Ülikoolis kaitstud Kairit Kauri, Mart Velskeri ja Aija Sakova-Merivee kirjandusalastest doktoritöödest. Lähemalt Aija Sakova-Merivee saksakeelsest dissertatsioonist "Väljakaevamine ja mäletamine. Mälutöö ja moraalse tunnistamise mõttepildid Ene Mihkelsoni ja Christa Wolfi romaanides". Tartu, 2014

  14. Protein tetrazinylation via diazonium coupling for covalent and catalyst-free bioconjugation.

    Science.gov (United States)

    Zhang, Jie; Men, Yuwen; Lv, Shanshan; Yi, Long; Chen, Jian-Feng

    2015-12-21

    An efficient and bench-stable reagent was synthesized for direct and covalent introduction of tetrazines onto target protein or virus surfaces, which can be further modified based on tetrazine-ene ligation to achieve fluorescence labelling or PEGylation under mild conditions.

  15. Statiese en dynamiese denkwijzen in pathologie en biologie

    NARCIS (Netherlands)

    Huisman, Rinco Gerrit Johan Pieter

    1924-01-01

    In de inleiding is gesproken over een tegenstelling in karakteraanleg, die het wezen zou zijn van de tegenstelling der theorieën. Als typen daarvoor zijn Herakleitos en Parmenides genomen en in het voorafgaande heb ik telkens aangegeven welke theorie de uiting was van het ene geestestype en welke

  16. Conductor : A multilingual programming environment for statistical software

    NARCIS (Netherlands)

    Jong, Volken Jelle de

    1988-01-01

    In dit proefschrift wordt een programmeeromgeving voor statistische software beschreven waarin voor elke groep experts een afzonderlijke programmeertaal is gecreëerd. Binnen de groep van statistische experts wordt daarbij onderscheid gemaakt, tussen aan de ene kant, experts op het gebied van de

  17. Eesti Kirjanike Liit praegu : ankeedivastused

    Index Scriptorium Estoniae

    1997-01-01

    Aut.: Ain Kaalep, Juhan Habicht, Valeria Ränik, Karl Muru, Mart Velsker, Janika Kronberg, Maie Kalda, Hannes Varblane, Toomas Raudam, Priidu Beier, Kati Murutar, Dagmar Normet, Enn Vetemaa, Henn-Kaarel Hellat, Vello Lattik, Kajar Pruul, Kauksi Ülle, Ene Mihkelson, Jüri Ehlvest

  18. Synthesis of ()-albrassitriol and ()-6-epi-albrassitriol from (+)-larixol

    NARCIS (Netherlands)

    Vlad, P.F.; Ciocarlan, A.; Coltsa, M.; Edu, C.; Biriiac, A.; Barba, A.; Deleanu, C.; Nicolescu, A.; Ambrosio, D' M.; Groot, de Æ.

    2013-01-01

    A novel synthesis of natural drimanic compounds, ()-albrassitriol (2) and ()-6-epi-albrassitriol (3), has been carried out starting from an easily available labdane diterpenoid, (+)-larixol (1). In a two-step procedure, (+)-larixol (1) was converted into 14,15-bisnorlab-7-ene-6,13-dione (9), which

  19. Blockbusteren som eksperimentalfilm

    DEFF Research Database (Denmark)

    Nielsen, Jakob Isak

    2014-01-01

    Artikel om Alfonso Cuaróns 'Gravity' (2013). Artiklen analyserer og diskuterer 'Gravity's audiovisuelle iscenesættelse og argumenterer for, at dens eksperimentelle iscenesættelsesstrategier på den ene side er idiosynkratiske, men at eksperimentelle impulser på den anden side tilhører en længere t...

  20. Ilves lennutati käepigistuseks hiiglaslikule sõjalaevale / Rasmus Kagge

    Index Scriptorium Estoniae

    Kagge, Rasmus, 1977-

    2007-01-01

    President Toomas Hendrik Ilves, Riigikogu esimees Ene Ergma, kaitseväe juht Ants Laaneots, kaitseminister Jaak Aaviksoo ja mitu parlamendiliiget külastasid Vahemeres seilavat maailma esimest tuumajõu abil liikuvat lennukikandjat USS Enterprise. Vabariigi Presidendi visiit Ameerika Ühendriikide sõjalaevastiku lennukikandjale USS Enterprise