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Sample records for ene essenson jri

  1. Microbial synthesis of alka(enes

    Directory of Open Access Journals (Sweden)

    Weihua eWang

    2013-10-01

    Full Text Available Alka(enes are the predominant constituents of gasoline, diesel, and jet fuels. They can be produced naturally by a wide range of microorganisms. Bio- alka(enes can be used as drop-in biofuels. To date, five microbial pathways that convert free fatty acids or fatty acid derivatives into alka(enes have been identified or reconstituted. The discoveries open a door to achieve microbial production of alka(enes with high efficiency. The modules derived from these alka(ene biosynthetic pathways can be assembled as biological parts and synthetic biology strategies can be employed to optimize the metabolic pathways and improve alka(ene production.

  2. Žene u politici

    OpenAIRE

    Podnar, Ivana

    2017-01-01

    Kroz povijest žene su uvijek bile podcjenjivane i osporavane, oduvijek se smatralo da je njihov zadatak biti kod kuće, brinuti se oko odgoja djece i istovremeno obavljati teške fizičke poslove u kućanstvu. Kako se razvijalo društvo, dolazi i do određenih promjena u položaju žena. S vremenom, počele su dobivati različite poslove, društvena prava, pravo glasa, a u konačnici i pravo odlučivanja i rada u politici. Iako danas živimo u 21. stoljeću, postoje dijelovi svijeta u kojima žene...

  3. Ene Sepp esitles esikteost "Medaljon" / Heli Talinurm

    Index Scriptorium Estoniae

    Talinurm, Heli

    2009-01-01

    Ene Sepp esitles 19. veebruaril Rapla Keskraamatukogus oma raamatut, mis pälvis kolmanda koha Eesti Lastekirjanduse Teabekeskuse ja kirjastuse Tänapäev 2008. aasta noorsooromaani võistlusel. Ly Ehini mõtteid, mida Ene Sepa raamat temas tekitas

  4. Catalytic Conia-ene and related reactions.

    Science.gov (United States)

    Hack, Daniel; Blümel, Marcus; Chauhan, Pankaj; Philipps, Arne R; Enders, Dieter

    2015-10-07

    Since its initial inception, the Conia-ene reaction, known as the intramolecular addition of enols to alkynes or alkenes, has experienced a tremendous development and appealing catalytic protocols have emerged. This review fathoms the underlying mechanistic principles rationalizing how substrate design, substrate activation, and the nature of the catalyst work hand in hand for the efficient synthesis of carbocycles and heterocycles at mild reaction conditions. Nowadays, Conia-ene reactions can be found as part of tandem reactions, and the road for asymmetric versions has already been paved. Based on their broad applicability, Conia-ene reactions have turned into a highly appreciated synthetic tool with impressive examples in natural product synthesis reported in recent years.

  5. ENES the European Network for Earth System modelling and its infrastructure projects IS-ENES

    Science.gov (United States)

    Guglielmo, Francesca; Joussaume, Sylvie; Parinet, Marie

    2016-04-01

    The scientific community working on climate modelling is organized within the European Network for Earth System modelling (ENES). In the past decade, several European university departments, research centres, meteorological services, computer centres, and industrial partners engaged in the creation of ENES with the purpose of working together and cooperating towards the further development of the network, by signing a Memorandum of Understanding. As of 2015, the consortium counts 47 partners. The climate modelling community, and thus ENES, faces challenges which are both science-driven, i.e. analysing of the full complexity of the Earth System to improve our understanding and prediction of climate changes, and have multi-faceted societal implications, as a better representation of climate change on regional scales leads to improved understanding and prediction of impacts and to the development and provision of climate services. ENES, promoting and endorsing projects and initiatives, helps in developing and evaluating of state-of-the-art climate and Earth system models, facilitates model inter-comparison studies, encourages exchanges of software and model results, and fosters the use of high performance computing facilities dedicated to high-resolution multi-model experiments. ENES brings together public and private partners, integrates countries underrepresented in climate modelling studies, and reaches out to different user communities, thus enhancing European expertise and competitiveness. In this need of sophisticated models, world-class, high-performance computers, and state-of-the-art software solutions to make efficient use of models, data and hardware, a key role is played by the constitution and maintenance of a solid infrastructure, developing and providing services to the different user communities. ENES has investigated the infrastructural needs and has received funding from the EU FP7 program for the IS-ENES (InfraStructure for ENES) phase I and II

  6. Kandidaadid : Ene Ergma versus Toomas Hendrik Ilves

    Index Scriptorium Estoniae

    2006-01-01

    Artiklis vastatakse küsimustele, kes oleksid Kadriorus Ene Ergma ja Toomas Hendrik Ilvese nõunikud, millist sõnumit kannaks nende esimene iseseisvuspäeva kõne, kuidas nad tähistaksid oma võitu presidendivalimistel, kellele nad annaksid Maarjamaa Risti, kuhu nad teeksid oma esimese välisvisiidi

  7. Unustamatu majapidaja / Ene Üleoja

    Index Scriptorium Estoniae

    Üleoja, Ene, 1937-

    2006-01-01

    23. oktoobril möödus 20 aastat peapiiskopi Edgar Hargi surmast. Teda meenutavad Kaarli koguduse koorijuht ja Eesti Muusika- ja Teatriakadeemia emeriitprofessor Ene Üleoja, emeriitpraost Esra Rahula, Vana Testamendi ja semitistika professor dr. Kalle Kasemaa ning peapiiskop emeriitus Kuno Pajula

  8. IS-ENES project management - lessons learnt

    Science.gov (United States)

    Parinet, Marie; Guglielmo, Francesca; Joussaume, Sylvie

    2017-04-01

    IS-ENES is the distributed e-infrastructure of models, model data and metadata of the European Network for Earth System Modelling (ENES). It has benefitted from two EC FP7 grants and aims towards further European and national funding to achieve sustainability. We highlight here several challenges related to project management that have risen in the course of these two project-phases spanning 8 years. Some challenges are related to the heterogeneity of the activities within IS-ENES, with different groups working on very diverse activities, not necessarily strictly interdependent. An immediate consequence is the need of implementing and setting up in early phases of the project efficient collection and circulation of information to preserve and reinforce the systemic view of the infrastructure as a whole and the pursuit of common goals, including coordinated provision of services. Toward and beyond such common goals, managing IS-ENES, covering both scientific and more strictly management-related aspects, implies a double-paced approach: besides setting up efficient project workflow, there is the need of setting up longer term objectives. This implies, within the project lifetime, to elaborate and implement a coherent organizational (consistent with scientific goals, funding schemes, research and technology landscape) strategy to pursue these goals beyond the project itself. Furthermore, a series of more generic project management challenges will also be listed and can be gathered around 3 main objectives: ease the internal processes in order to optimize the work, anticipate delays and budget issues, and motivate the project teams by ensuring an efficient internal and external communication.

  9. Hydroxylative activity of Aspergillus niger towards androst-4-ene and androst-5-ene steroids.

    Science.gov (United States)

    Świzdor, Alina; Panek, Anna; Milecka-Tronina, Natalia

    2017-10-01

    Aspergillus niger, one of fungal species most frequently used for experimental and industrial-scale biotransformations of various organic compounds, is generally known to transform steroids at 16β position. In this work, application of the strain A. niger KCH910 to bioconversion of dehydroepiandrosterone (DHEA), androstenediol and testosterone is described, with emphasis on the metabolic steps leading to the products. Evidence from this study indicated that incubated 5-ene steroids underwent bioconversion within two metabolic pathways: oxidation by the action of 3β-HSD (3β-hydroxysteroid dehydrogenase) to 4-ene steroids, and minor allylic hydroxylation to epimeric 7-alcohols. Further transformation of the 3-oxo-4-ene metabolites resulted in non-selective 16-hydroxylation. It is the first report on an A. niger strain able to introduce not only 16β- but also 16α-hydroxyl function into steroids. Copyright © 2017. Published by Elsevier Inc.

  10. Hybrid Organic/Inorganic Thiol-ene-Based Photopolymerized Networks

    OpenAIRE

    Schreck, Kathleen M.; Leung, Diana; Bowman, Christopher N.

    2011-01-01

    The thiol-ene reaction serves as a more oxygen tolerant alternative to traditional (meth)acrylate chemistry for forming photopolymerized networks with numerous desirable attributes including energy absorption, optical clarity, and reduced shrinkage stress. However, when utilizing commercially available monomers, many thiol-ene networks also exhibit decreases in properties such as glass transition temperature (Tg) and crosslink density. In this study, hybrid organic/inorganic thiol-ene resins ...

  11. Sa uurisid ekspressionismi 1960ndatel ja 70ndatel... / Ene Lamp

    Index Scriptorium Estoniae

    Lamp, Ene

    2005-01-01

    2004. a. ilmunud raamatu "Ekspressionism" eest Eesti Kultuurkapitali suure kunstipreemia (100000 kr.) saanud Ene Lamp ekspressionismi tähenduse muutumiset, ekspressionismi rollist eesti kunstis, oma tulevikuplaanidest

  12. preparation of bicyclic lactones using lewis acids catalyzed ene

    African Journals Online (AJOL)

    Administrator

    LEWIS ACIDS CATALYZED ENE-REACTION. MAKAMA, B. Y.. Department of Petroleum Chemistry, ... the Lewis acid catalysed carbonyl-ene reaction which has been widely used to access carbocycles. In 1943 ..... Alkylaluminum halide induced cyclization of unsaturated carbonyl compounds. Journal of Organic Chemistry.

  13. Photopolymerized Thiol-Ene Systems as Shape Memory Polymers

    Science.gov (United States)

    Nair, Devatha P.; Cramer, Neil B.; Scott, Timothy F.; Bowman, Christopher N.; Shandas, Robin

    2010-01-01

    In this study we introduce the use of thiol-ene photopolymers as shape memory polymer systems. The thiol-ene polymer networks are compared to a commonly utilized acrylic shape memory polymer and shown to have significantly improved properties for two different thiol-ene based polymer formulations. Using thermomechanical and mechanical analysis, we demonstrate that thiol-ene based shape memory polymer systems have comparable thermomechanical properties while also exhibiting a number of advantageous properties due to the thiol-ene polymerization mechanism which results in the formation of a homogenous polymer network with low shrinkage stress and negligible oxygen inhibition. The resulting thiol-ene shape memory polymer systems are tough and flexible as compared to the acrylic counterparts. The polymers evaluated in this study were engineered to have a glass transition temperature between 30 and 40 °C, exhibited free strain recovery of greater than 96% and constrained stress recovery of 100%. The thiol-ene polymers exhibited excellent shape fixity and a rapid and distinct shape memory actuation response. PMID:21072253

  14. An academic with ambition / Ene Ergma ; interv. Kadri Kukk

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2006-01-01

    Intervjuus Riigikogu asespiikriga käsitletakse kõrghariduse korraldust, professorite rohkust kõrgkoolides, võimalikku kandideerimist Tartu ülikooli rektori kohale, omandatud poliitilisi kogemusi ning ajude äravoolu Eestist. Ene Ergma CV

  15. Tandem Wittig-ene reaction approach to kainic acid

    Digital Repository Service at National Institute of Oceanography (India)

    Majik, M.S.; Parameswaran, P; Tilve, S.G.

    The first example of a tandem Wittig-intramolecular ene reaction approach and its application toward the synthesis of kainic acid is reported. The synthetic pathway involves conversion of prenyl bromide into phosphorane 3, followed by one-pot Wittig...

  16. 5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry.

    Science.gov (United States)

    Kaminskyy, Danylo; Kryshchyshyn, Anna; Lesyk, Roman

    2017-11-10

    The presented review is an attempt to summarize a huge volume of data on 5-ene-4-thiazolidinones being a widely studied class of small molecules used in modern organic and medicinal chemistry. The manuscript covers approaches to the synthesis of 5-ene-4-thiazolidinone derivatives: modification of the C5 position of the basic core; synthesis of the target compounds in the one-pot or multistage reactions or transformation of other related heterocycles. The most prominent pharmacological profiles of 5-ene derivatives of different 4-thiazolidinone subtypes belonging to hit-, lead-compounds, drug-candidates and drugs as well as the most studied targets have been discussed. Currently target compounds (especially 5-en-rhodanines) are assigned as frequent hitters or pan-assay interference compounds (PAINS) within high-throughput screening campaigns. Nevertheless, the crucial impact of the presence/nature of C5 substituent (namely 5-ene) on the pharmacological effects of 5-ene-4-thiazolidinones was confirmed by the numerous listed findings from the original articles. The main directions for active 5-ene-4-thiazolidinones optimization have been shown: i) complication of the fragment in the C5 position; ii) introduction of the substituents in the N3 position (especially fragments with carboxylic group or its derivatives); iii) annealing in complex heterocyclic systems; iv) combination with other pharmacologically attractive fragments within hybrid pharmacophore approach. Moreover, the utilization of 5-ene-4-thiazolidinones in the synthesis of complex compounds with potent pharmacological application is described. The chemical transformations cover mainly the reactions which involve the exocyclic double bond in C5 position of the main core and correspond to the abovementioned direction of the 5-ene-4-thiazolidinone modification. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  17. Cysteine-functional polymers via thiol-ene conjugation.

    Science.gov (United States)

    Kuhlmann, Matthias; Reimann, Oliver; Hackenberger, Christian P R; Groll, Jürgen

    2015-03-01

    A thiofunctional thiazolidine is introduced as a new low-molar-mass building block for the introduction of cysteine residues via a thiol-ene reaction. Allyl-functional polyglycidol (PG) is used as a model polymer to demonstrate polymer-analogue functionalization through reaction with the unsaturated side-chains. A modified trinitrobenzenesulfonic acid (TNBSA) assay is used for the redox-insensitive quantification and a precise final cysteine content can be predetermined at the polymerization stage. Native chemical ligation at cysteine-functional PG is performed as a model reaction for a chemoselective peptide modification of this polymer. The three-step synthesis of the thiofunctional thiazolidine reactant, together with the standard thiol-ene coupling and the robust quantification assay, broadens the toolbox for thiol-ene chemistry and offers a generic and straightforward approach to cysteine-functional materials. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Highly tailorable thiol-ene based emulsion-templated monoliths

    DEFF Research Database (Denmark)

    Lafleur, J. P.; Kutter, J. P.

    2014-01-01

    The attractive surface properties of thiol-ene polymers combined with their ease of processing make them ideal substrates in many bioanalytical applications. We report the synthesis of highly tailorable emulsion-templated porous polymers and beads in microfluidic devices based on off-stoichiometr......The attractive surface properties of thiol-ene polymers combined with their ease of processing make them ideal substrates in many bioanalytical applications. We report the synthesis of highly tailorable emulsion-templated porous polymers and beads in microfluidic devices based on off......-stoichiometry thiolene chemistry. The method allows monolith synthesis and anchoring inside thiol-ene microchannels in a single step. Variations in the monomer stoichiometric ratios and/or amount of porogen used allow for the creation of extremely varied polymer morphologies, from foam-like materials to dense networks...

  19. One-pot desymmetrizing hydroformylation/carbonyl ene cyclization process: straightforward access to highly functionalized cyclohexanols.

    Science.gov (United States)

    Bigot, Aurélien; Breuninger, Daniel; Breit, Bernhard

    2008-12-04

    Rapid access to highly functionalized alkylidene cyclohexanols through a one-pot desymmetrizing hydroformylation/carbonyl ene cyclization starting from simple bisalkenylcarbinols is reported. Mechanistic insight into the carbonyl ene reaction is given, highlighting the importance of hyperconjugative substituent effects.

  20. Hybrid Organic/Inorganic Thiol-ene-Based Photopolymerized Networks.

    Science.gov (United States)

    Schreck, Kathleen M; Leung, Diana; Bowman, Christopher N

    2011-09-15

    The thiol-ene reaction serves as a more oxygen tolerant alternative to traditional (meth)acrylate chemistry for forming photopolymerized networks with numerous desirable attributes including energy absorption, optical clarity, and reduced shrinkage stress. However, when utilizing commercially available monomers, many thiol-ene networks also exhibit decreases in properties such as glass transition temperature (T(g)) and crosslink density. In this study, hybrid organic/inorganic thiol-ene resins incorporating silsesquioxane (SSQ) species into the photopolymerized networks were investigated as a route to improve these properties. Thiol- and ene-functionalized SSQs (SH-SSQ and allyl-SSQ, respectively) were synthesized via alkoxysilane hydrolysis/condensation chemistry, using a photopolymerizable monomer [either pentaerythriol tetrakis(3-mercaptopropionate) (PETMP) or 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (TATATO)] as the reaction solvent. The resulting SSQ-containing solutions (SSQ-PETMP and SSQ-TATATO) were characterized, and their incorporation into photopolymerized networks was evaluated.

  1. Proof of a conjecture of Colliot-Th\\'el\\`ene

    OpenAIRE

    Denef, Jan

    2011-01-01

    We prove a conjecture of Colliot-Th\\'el\\`ene that implies the Ax-Kochen Theorem on p-adic forms. We obtain it as an easy consequence of a diophantine excision theorem whose proof forms the body of the present paper.

  2. Ene ja Tõnis Kask pole valikuga rahul / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2003-01-01

    Eesti Filmiajakirjanike Ühing andis auhinna Aasta film 2002 mängufilmile "Agent Sinikael" : režissöör Marko Raat. Viimane sai preemiaks 12 000 krooni. Auhinna rahastajad omanimelise fondi kaudu Eesti Rahvuskultuuri Fondi juures Ene ja Tõnis Kask peavad "Nimed marmortahvlil" väljajätmist isegi nominentide hulgast shokeerivaks

  3. Fabrication and bonding of thiol-ene-based microfluidic devices

    DEFF Research Database (Denmark)

    Sikanen, Tiina M; Lafleur, Josiane P.; Moilanen, Maria-Elisa

    2013-01-01

    In this work, the bonding strength of microchips fabricated by thiol-ene free-radical polymerization was characterized in detail by varying the monomeric thiol/allyl composition from the stoichiometric ratio (1:1) up to 100% excess of thiol (2:1) or allyl (1:2) functional groups. Four different...

  4. Surface functionalized thiol-ene waveguides for fluorescence biosensing in microfluidic devices

    DEFF Research Database (Denmark)

    Feidenhans'l, Nikolaj Agentoft; Lafleur, Josiane P.; Jensen, Thomas Glasdam

    2013-01-01

    -ene materials vary considerably with variations in stoichiometric composition, their optical properties remain mostly unchanged with an average refractive index value of 1.566 ± 0.008 for thiol-ene substrates encompassing a range from 150% excess ene to 90% excess thiol. Microfluidic chips featuring thiol......Thiol-ene polymers possess physical, optical, and chemical characteristics thatmake them ideal substrates for the fabrication of optofluidic devices. In this work, thiol-ene polymers are used to simultaneously create microfluidic channels and optical waveguides in one simple moulding step...

  5. Essenson tuleb välja soolotükiga / Katrin Essenson ; interv. Tiit Tuumalu

    Index Scriptorium Estoniae

    Essenson, Katrin, 1973-

    2005-01-01

    14. sept. esietendub Kanuti gildi saalis koreograafi, tantsija ja performance'i kunstniku K. Essensoni soololavastus "Manusega mõtted : Designed to make difference". Lavastusele on dramaturgina kaasa aidanud Von Krahli teatri näitleja T. Eelmaa

  6. Katrin Essenson avastab uusi tähendusi / Katrin Essenson ; interv. Mihkel Niglas

    Index Scriptorium Estoniae

    Essenson, Katrin, 1973-

    2006-01-01

    Üks Philip Morrise tantsuauhinna nominente, vabakutseline tantsija, kes koostöös näitleja Taavi Eelmaaga lõi sooloetenduse "Manusega mõtted". Lisaks "Philip Morris Eesti 2005. aasta tantsuauhindade nominendid" ja sõnum "Homme tähistatakse tantsupäeva"

  7. 5 küsimust Ene Läkile / Ene Läkk ; interv. Ell-Maaja Randküla

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2006-01-01

    Ene Läkist, kes on alates 2005. aastast interjööri-, disaini- ja arhitektuuriajakirja "Ruum" peatoimetaja. Ene Läkk, Eesti Sisearhitektide Liidu 2005. a. aastapreemia nominent ajakirjandusliku tegevuse eest, ajakirjast "Ruum". Ill.: 6 värv. vaadet, foto ajakirjanikust

  8. Ene-Liiz Semper. Anton Litvin. Bogdan Mamonov

    Index Scriptorium Estoniae

    2005-01-01

    Veebruaris Madridis toimunud Euroopa kunstilaada ARCO jaoks Vene saatkonna galerii poolt koostatud kunstinäitus TRINITY toimub nüüd Tallinnas Vene saatkonna galeriis. Kuraatorid Masha ja Andrei Melnikovid. Osalevad Ene-Liis Semper videoga ArtVideo, vene kunstnik Bogdan Mamonov maaliseeriaga "Ma kanoniseerisin oma sõpru" ja vene kunstnik Anton Litvin fotoprojektiga "Punktuatsioon". Madridis näitas Semper videot "Nimetu"

  9. Functional Conducting Polymers via Thiol-ene Chemistry

    OpenAIRE

    Feldman, Kathleen E.; Martin, David C.

    2012-01-01

    We demonstrate here that thiol-ene chemistry can be used to provide side-chain functionalized monomers based on 3,4-propylenedioxythiophene (ProDOT) containing ionic, neutral, hydrophobic, and hydrophilic side chains. All reactions gave high yields and purification could generally be accomplished through precipitation. These monomers were polymerized either chemically or electro-chemically to give soluble materials or conductive films, respectively. This strategy provides for facile tuning of...

  10. Elastomeric and degradable polyanhydride network polymers by step-growth thiol-ene photopolymerization.

    Science.gov (United States)

    Shipp, Devon A; McQuinn, Christopher W; Rutherglen, Broden G; McBath, Ryan A

    2009-11-14

    Linear and crosslinked polyanhydrides can be made using photoinitiated thiol-ene chemistry, a simple and effective method of making crosslinked structures that have surface degradation characteristics.

  11. ENE-Mates - A public information program for women

    International Nuclear Information System (INIS)

    Nagashima, Kyoko

    1995-01-01

    Japan depends on import for more than 80 percent of its total energy supply. Nuclear energy is one of the most promising alternatives to oil. It plays a significant role for energy supply in terms of reliability, economic viability and reduction of CO 2 emissions. In order to secure needed capacity, the Government concentrates its efforts on acquiring public acceptance of nuclear power as well as ensuring the safety of plants and improving plant capability and reliability. An opinion poll, done by the Japanese Government in Sep. of 1990, showed that 73.3 percent of man and 57.4 percent of women think that nuclear power is necessary to secure energy supply. Nuclear Power Engineering Corporation (NUPEC) employs various methods for information services arid, in particular, electric power generation including nuclear with an assignment from the Japanese Government. Public information activities by the Nuclear Power Engineering Corporation (NUPEC) are as follows: a) Telephone QA service to respond to public inquiries; b) Publishing the 'Nuclear Newsletter' monthly and various brochures; c) Information service by personal computer network Atomnet concerning energy in general, and operation/trouble informations of nuclear plants; d) Distribution and service of personal computers to local governments offices/museums, etc., for users ranging from children to adults to gather nuclear related information; e) Organization of female monitors 'ENE-MATES' to have lecture meetings and site tours. ENE-MATES - A Public Information Program For Women. As a 1990 opinion poll shows, women's feelings about nuclear energy differ from that of men. Women are more sensitive and anxious than men on nuclear energy issues. To improve this situation several programs for women have been planned and implemented.'ENE-MATES' program is one of these cases. It's purpose is to encourage women, centering around house wives, to have unbiased understanding of energy-related issues

  12. Naknada štete prouzročene kaznenim djelom

    OpenAIRE

    Votić, Antonija

    2016-01-01

    Tema ovog završnog rada je naknada štete prouzročene kaznenim djelom. U tom radu autorica je obuhvatila sljedeća poglavlja; opće i posebne pretpostavke odgovornosti za štetu, subjekte obveznog odnosa odgovornosti za štetu, nadalje vrste odgovornosti, vlastitu odgovornost, odgovornost za drugoga i odgovornost više osoba za istu štetu zatim je objasnila posebne slučajeve odgovornosti, popravljanje štete te uklanjanje opasnosti štete. Autorica je posebnu pozornost pridodala poglavljima o kazn...

  13. Novel Thiol-Ene Hybrid Coating for Metal Protection

    Directory of Open Access Journals (Sweden)

    Mona Taghavikish

    2016-04-01

    Full Text Available A novel hybrid anticorrosion coating with dual network of inorganic (Si–O–Si and organic bonds (C–S–C was prepared on metal through an in situ sol-gel and thiol-ene click reaction. This novel interfacial thin film coating incorporates (3-mercaptopropyl trimethoxysilane (MPTS and 1,4-di(vinylimidazolium butane bisbromide based polymerizable ionic liquid (PIL to form a thiol-ene based photo-polymerized film, which on subsequent sol-gel reaction forms a thin hybrid interfacial layer on metal surface. On top of this PIL hybrid film, a self-assembled nanophase particle (SNAP coating was employed to prepare a multilayer thin film coating for better corrosion protection and barrier performance. The novel PIL hybrid film was characterised for structure and properties using Fourier transform infrared spectroscopy (FTIR, differential scanning calorimetry (DSC, and thermogravimetric analysis (TGA. The corrosion protection performance of the multilayer coating was examined using potentiodynamic polarization and electrochemical impedance spectroscopy (EIS. The results reveal that this novel double layer coating on metal offers excellent protection against corrosion and has remarkably improved the barrier effect of the coating.

  14. Thiol-ene click chemistry: a biocompatible way for orthogonal bioconjugation of colloidal nanoparticles.

    Science.gov (United States)

    Liu, Yuan; Hou, Weijia; Sun, Hao; Cui, Cheng; Zhang, Liqin; Jiang, Ying; Wu, Yongxiang; Wang, Yanyue; Li, Juan; Sumerlin, Brent S; Liu, Qiaoling; Tan, Weihong

    2017-09-01

    Bioconjugation based on crosslinking primary amines to carboxylic acid groups has found broad applications in protein modification, drug development, and nanomaterial functionalization. However, proteins, which are made up of amino acids, typically give nonselective bioconjugation when using primary amine-based crosslinking. In order to control protein orientation and activity after conjugation, selective bioconjugation is desirable. We herein report an efficient and cysteine-selective thiol-ene click reaction-based bioconjugation strategy using colloidal nanoparticles. The resulting thiol-ene based aptamer and enzyme nanoconjugates demonstrated excellent target binding ability and enzymatic activity, respectively. Thus, thiol-ene click chemistry can provide a stable and robust crosslinker in a biocompatible manner for bioconjugation of any thiol-containing biomolecule with nanomaterials. This will open more opportunities for applications of thiol-ene reactions and functional colloidal nanoparticles in chemical biology.

  15. Investigations of thiol-modified phenol derivatives for the use in thiol–ene photopolymerizations

    OpenAIRE

    Sebastian Reinelt; Monir Tabatabai; Urs Karl Fischer; Norbert Moszner; Andreas Utterodt; Helmut Ritter

    2014-01-01

    Summary Thiol–ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol–ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate) (PETMP), is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-m...

  16. Method for preparation of specifically tritium-labelled 5α-androst-16-ene-3-one

    International Nuclear Information System (INIS)

    Roemer, J.; Wagner, H.; Kunz, G.

    1987-01-01

    A method is described for preparing 3 H-labelled 5α-androst-16-ene-3-one of high specific activity, needed to a growing extent in agricultural research institutions for radioimmunoassay of the boar pheromone 5α-androst-16-ene-3-one. A storable and easily accessible 16-androstene is subjected to reductive catalytic tritiation and, in two further stages, converted into the target product

  17. Draama 2007. Töörahu / Ene Paaver

    Index Scriptorium Estoniae

    Paaver, Ene, 1963-

    2008-01-01

    Ülevaade 2007. aasta eesti draamast. Pikemalt käsitletakse järgmisi autoreid ja nende näidendeid: Mart Kivastik "Tõnu võitlused", Mart Kivastik "Eesti asi", Mart Kivastik "Sõdur", Mart Kivastik "Kuninga viimane lahing ja ülikooli algus", Mart Kivastik, "Nokia 3310", Andrus Kivirähk "Voldemar", Andrus Kivirähk "Uljas neitsi", Hendrik Toompere "Kommunisti surm", Andres Ehin "Saatuslik kihlvedu ehk Volquin Varbola all", Jan Rahman "Jõujaam", Jaak Kõdar "Muinassaar", Karl Berg "Teekond valguse riiki", Angela Randmets "Lembelood vanas linnas", Toomas Kall "Tähtede sadu", Lauri Vahtre "Muna EÜE", Urmas Espenberg "Kestvad kiiduavaldused", Kalju Saaber "Koduvõõrad", Indrek Hirv "Pauluse kiriku kellad", Katrin Saukas "Võlg", Heidi Sarapuu "Austatud Riigikogu liikmed!", Heidi Sarapuu "Helisev viis", Heidi Sarapuu "Ankur hiivata", Jakob Karu "Vanaema juures", Jim Ashilevi "Nagu poisid vihma käes", Jim Ashilevi "Portselansuits", Eva Koff "Mirr", Jaak Prints "Karaoke", Kati Murutar "Mina, naine!", Ott Aardam "Börs ja Börsitar", Andrus Kivirähk, Jan Rahman, Contra "Kõrts", Mart Kase "Perekond", Villu Tamme "Haned võlgu"; Tiit Ojasoo ja Ene-Liis Semperi "GEP ehk Gorjatshije estonskije parni"

  18. Surface Eroding, Semicrystalline Polyanhydrides via Thiol-Ene "Click" Photopolymerization.

    Science.gov (United States)

    Poetz, Katie L; Mohammed, Halimatu S; Shipp, Devon A

    2015-05-11

    Surface eroding and semicrystalline polyanhydrides, with tunable erosion times and drug delivery pharmacokinetics largely dictated by erosion, are produced easily with thiol-ene "click" polymerization. This strategy yields both linear and cross-linked network polyanhydrides that are readily and fully cured within minutes using photoinitiation, can contain up to 60% crystallinity, and have tensile moduli up to 25 MPa for the compositions studied. Since they readily undergo hydrolysis and exhibit the oft-preferred surface erosion mechanism, they may be particularly useful in drug delivery applications. The polyanhydrides were degraded under pseudophysiological conditions and cylindrical samples (10 mm diameter × 5 mm height) were completely degraded within ∼10 days, with the mass-time profile being linear for much of this time after a ∼24 h induction period. Drug release studies, using lidocaine as a model, showed pharmacokinetics that displayed a muted burst release in the early stages of erosion, but then a delayed release profile that is closely correlated to the erosion kinetics. Furthermore, cytotoxicity studies of the linear and cross-linked semicrystalline polyanhydrides, and degradation products, against fibroblast cells indicate that the materials have good cytocompatibility. Overall, cells treated with up to 2500 mg/L of the semicrystalline polyanhydrides and degradation products show >90% human dermal fibroblast adult (HDFa) cell viability indicative of good cytocompatibility.

  19. Simple preparation of thiol-ene particles in glycerol and surface functionalization by thiol-ene chemistry (TEC) and surface chain transfer free radical polymerization (SCT-FRP)

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Chiaula, Valeria; Pinelo, Manuel

    2018-01-01

    functionalization of excess thiol groups via photochemical thiol-ene chemistry (TEC) resulting in a functional monolayer. In addition, surface chain transfer free radical polymerization (SCT-FRP) was used for the first time to introduce a thicker polymer layer on the particle surface. The application potential...

  20. Preparation and Preliminary Dielectric Characterization of Structured C60-Thiol-Ene Polymer Nanocomposites Assembled Using the Thiol-Ene Click Reaction.

    Science.gov (United States)

    Ahmed, Hanaa M; Windham, Amber D; Al-Ejji, Maryam M; Al-Qahtani, Noora H; Hassan, Mohammad K; Mauritz, Kenneth A; Buchanan, Randy K; Buchanan, J Paige

    2015-11-18

    Fullerene-containing materials have the ability to store and release electrical energy. Therefore, fullerenes may ultimately find use in high-voltage equipment devices or as super capacitors for high electric energy storage due to this ease of manipulating their excellent dielectric properties and their high volume resistivity. A series of structured fullerene (C 60 ) polymer nanocomposites were assembled using the thiol-ene click reaction, between alkyl thiols and allyl functionalized C 60 derivatives. The resulting high-density C 60 -urethane-thiol-ene (C 60 -Thiol-Ene) networks possessed excellent mechanical properties. These novel networks were characterized using standard techniques, including infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and thermal gravimetric analysis (TGA). The dielectric spectra for the prepared samples were determined over a broad frequency range at room temperature using a broadband dielectric spectrometer and a semiconductor characterization system. The changes in thermo-mechanical and electrical properties of these novel fullerene-thiol-ene composite films were measured as a function of the C 60 content, and samples characterized by high dielectric permittivity and low dielectric loss were produced. In this process, variations in chemical composition of the networks were correlated to performance characteristics.

  1. Preparation and Preliminary Dielectric Characterization of Structured C60-Thiol-Ene Polymer Nanocomposites Assembled Using the Thiol-Ene Click Reaction

    Directory of Open Access Journals (Sweden)

    Hanaa M. Ahmed

    2015-11-01

    Full Text Available Fullerene-containing materials have the ability to store and release electrical energy. Therefore, fullerenes may ultimately find use in high-voltage equipment devices or as super capacitors for high electric energy storage due to this ease of manipulating their excellent dielectric properties and their high volume resistivity. A series of structured fullerene (C60 polymer nanocomposites were assembled using the thiol-ene click reaction, between alkyl thiols and allyl functionalized C60 derivatives. The resulting high-density C60-urethane-thiol-ene (C60-Thiol-Ene networks possessed excellent mechanical properties. These novel networks were characterized using standard techniques, including infrared spectroscopy (FTIR, differential scanning calorimetry (DSC, dynamic mechanical analysis (DMA, and thermal gravimetric analysis (TGA. The dielectric spectra for the prepared samples were determined over a broad frequency range at room temperature using a broadband dielectric spectrometer and a semiconductor characterization system. The changes in thermo-mechanical and electrical properties of these novel fullerene-thiol-ene composite films were measured as a function of the C60 content, and samples characterized by high dielectric permittivity and low dielectric loss were produced. In this process, variations in chemical composition of the networks were correlated to performance characteristics.

  2. Ene-Liis Semper : hindan päeva, kui teen ühte asja / Ene-Liis Semper ; interv. Jaanus Kulli

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2008-01-01

    Teatri- ja videokunstnik Ene-Liis Semper oma elust ja tööst. Lisaks repliik "Parim päev on tööst prii päev" ja peagi Teater NO99s esietenduvast William Shakespeare'i lavastusest "Muinasjutuline "Perikles"

  3. Rapid and simple preparation of thiol-ene emulsion-templated monoliths and their application as enzymatic microreactors

    DEFF Research Database (Denmark)

    Lafleur, Josiane P; Senkbeil, Silja; Novotny, Jakub

    2015-01-01

    A novel, rapid and simple method for the preparation of emulsion-templated monoliths in microfluidic channels based on thiol-ene chemistry is presented. The method allows monolith synthesis and anchoring inside thiol-ene microchannels in a single photoinitiated step. Characterization by scanning...... electron microscopy showed that the methanol-based emulsion templating process resulted in a network of highly interconnected and regular thiol-ene beads anchored solidly inside thiol-ene microchannels. Surface area measurements indicate that the monoliths are macroporous, with no or little micro...

  4. Investigations of thiol-modified phenol derivatives for the use in thiol-ene photopolymerizations.

    Science.gov (United States)

    Reinelt, Sebastian; Tabatabai, Monir; Fischer, Urs Karl; Moszner, Norbert; Utterodt, Andreas; Ritter, Helmut

    2014-01-01

    Thiol-ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol-ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate) (PETMP), is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-modified bis- and trisphenol derivatives in thiol-ene photopolymerizations. For this, six different thiol-modified bis- and trisphenol derivatives exhibiting four to six thiol groups are synthesized via the radical addition of thioacetic acid to suitable allyl-modified precursors and subsequent hydrolysis. Compared to PETMP better flexural strength and modulus of elasticity are achievable in thiol-ene photopolymerizations employing 1,3,5-triallyl-1,3,5-triazine-2,4,6-trione (TATATO) as the ene derivative. Especially, after storage in water, the flexural strength and modulus of elasticity is twice as high compared to the PETMP reference system.

  5. Investigations of thiol-modified phenol derivatives for the use in thiol–ene photopolymerizations

    Science.gov (United States)

    Reinelt, Sebastian; Tabatabai, Monir; Fischer, Urs Karl; Moszner, Norbert; Utterodt, Andreas

    2014-01-01

    Summary Thiol–ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol–ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate) (PETMP), is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-modified bis- and trisphenol derivatives in thiol–ene photopolymerizations. For this, six different thiol-modified bis- and trisphenol derivatives exhibiting four to six thiol groups are synthesized via the radical addition of thioacetic acid to suitable allyl-modified precursors and subsequent hydrolysis. Compared to PETMP better flexural strength and modulus of elasticity are achievable in thiol–ene photopolymerizations employing 1,3,5-triallyl-1,3,5-triazine-2,4,6-trione (TATATO) as the ene derivative. Especially, after storage in water, the flexural strength and modulus of elasticity is twice as high compared to the PETMP reference system. PMID:25161731

  6. Investigations of thiol-modified phenol derivatives for the use in thiol–ene photopolymerizations

    Directory of Open Access Journals (Sweden)

    Sebastian Reinelt

    2014-07-01

    Full Text Available Thiol–ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol–ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate (PETMP, is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-modified bis- and trisphenol derivatives in thiol–ene photopolymerizations. For this, six different thiol-modified bis- and trisphenol derivatives exhibiting four to six thiol groups are synthesized via the radical addition of thioacetic acid to suitable allyl-modified precursors and subsequent hydrolysis. Compared to PETMP better flexural strength and modulus of elasticity are achievable in thiol–ene photopolymerizations employing 1,3,5-triallyl-1,3,5-triazine-2,4,6-trione (TATATO as the ene derivative. Especially, after storage in water, the flexural strength and modulus of elasticity is twice as high compared to the PETMP reference system.

  7. Surface modification of cyclomatrix polyphosphazene microsphere by thiol-ene chemistry and lectin recognition

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chen; Zhu, Xue-yan; Gao, Qiao-ling; Fang, Fei; Huang, Xiao-jun, E-mail: hxjzxh@zju.edu.cn

    2016-11-30

    Graphical abstract: A new synthetic route leading to polyphosphazene cyclomatrix microsphere with various functional groups has achieved via thiol-ene click modification. Herein, hexacholorocyclophosphazene (HCCP) crosslinked with bisphenol-S and 4,4′-diallyl bisphenol-S to generate broadly dispersed microspheres. Thiol-ene modification under UV irradiation not only presented high efficiency and flexibility for post-functionalization, but also imposed no harm on global morphology and crosslinked skeleton of such microspheres. - Highlights: • Functional polyphosphazene microspheres with high chemical flexibility were synthesized by thiol-ene modification. • Polyphosphazene microspheres possessed high thermal stability. • Glycosylated polyphosphazene microspheres showed affinity to lectin Con-A, which inferred potential application in biomedicine. - Abstract: A new synthetic route leading to functional polyphosphazene cyclomatrix microsphere has been developed via thiol-ene click modification. Hexacholorocyclophosphazene (HCCP) was crosslinked with both bisphenol-S and 4,4′-diallyl bisphenol-S to obtain vinyl polyphosphazene microspheres (VPZM) in order to ensure high crosslinking degree and introduce vinyl moieties. Compared to the microspheres obtained by HCCP and bisphenol-S, the size of VPZM was broadly dispersed from 400 nm to 1.40 μm. Thiol-ene click reactions were carried out to attach functional groups, such as glucosyl, carboxyl, ester and dodecyl groups onto polyphosphazene microspheres, which demonstrated no change in morphology and size after modification. Solid state NMR (SSNMR) and Fourier transform infrared spectoscopy (FT-IR) results showed that the vinyl moieties were introduced in the period of crosslinking and functionalization was also successful via click reactions. Moreover, the microspheres presented a little difference in thermal properties after modification. Concanavalin A (Con-A) fluorescent adsorption was also observed for

  8. Ene-yne tetrahydrofurans from the sponge Xestospongia muta. exploiting a weak CD effect for assignment of configuration.

    Science.gov (United States)

    Morinaka, Brandon I; Skepper, Colin K; Molinski, Tadeusz F

    2007-05-10

    Seven new brominated ene-yne tetrahydrofurans (THFs), mutafurans A-G, were isolated from the Bahamian sponge Xestospongia muta. The absolute configuration of the natural products was assigned as (5R,8S) by interpretation of the Cotton effect arising from weak perturbation of an ene-yne chromophore by a propargylic THF ring.

  9. Evaluation and Control of Thiol-ene/Thiol-epoxy Hybrid Networks

    OpenAIRE

    Carioscia, Jacquelyn A.; Stansbury, Jeffrey W.; Bowman, Christopher N.

    2007-01-01

    The development of thiol-ene/thiol-epoxy hybrid networks offers the advantage of tailorable polymerization kinetics while producing a highly crosslinked, high Tg polymer that has significantly reduced shrinkage stress. Stoichiometric mixtures of pentaerythritol tetra(3-mercaptopropionate) (PETMP)/triallyl-1,3,5-triazine-2,4,6-trione (TATATO) (thiol-ene, mixture 1) and PETMP/bisphenol a diglycidyl ether (BADGE) (thiol-epoxy, mixture 2) were prepared and hybrid mixtures of 75/25, 50/50, 25/75, ...

  10. Preparation and Characterization of Fluorinated Hydrophobic UV-Crosslinkable Thiol-Ene Polyurethane Coatings

    Directory of Open Access Journals (Sweden)

    Wenjing Xia

    2017-08-01

    Full Text Available The polyurethane prepolymer terminated with a double bond was synthesized using isophorone diisocyanate (IPDI, hydroxyl terminated polybutadiene (HTPB, 1,4-butanediol (BDO, and 2-hydroxyethyl acrylate (HEA. Then, a series of innovative UV-curable polyurethane coatings were prepared by blending ene-terminated polyurethane, fluoroacrylate monomer, and multifunctional thiol crosslinker upon UV exposure. The incorporation of fluoroacrylate monomer and multifunctional thiols into polyurethane coatings significantly enhanced the hydrophobic property, mechanical property, pencil hardness, and glossiness of the polyurethane coatings. This method of preparing UV crosslinkable, hydrophobic polyurethane coatings based on thiol-ene chemistry exhibited numerous advantages over other UV photocuring systems.

  11. Preparation and Preliminary Dielectric Characterization of Structured C60-Thiol-Ene Polymer Nanocomposites Assembled Using the Thiol-Ene Click Reaction

    OpenAIRE

    Ahmed, Hanaa M.; Windham, Amber D.; Al-Ejji, Maryam M.; Al-Qahtani, Noora H.; Hassan, Mohammad K.; Mauritz, Kenneth A.; Buchanan, Randy K.; Buchanan, J. Paige

    2015-01-01

    Fullerene-containing materials have the ability to store and release electrical energy. Therefore, fullerenes may ultimately find use in high-voltage equipment devices or as super capacitors for high electric energy storage due to this ease of manipulating their excellent dielectric properties and their high volume resistivity. A series of structured fullerene (C60) polymer nanocomposites were assembled using the thiol-ene click reaction, between alkyl thiols and allyl functionalized C60 deri...

  12. Evaluation and Control of Thiol-ene/Thiol-epoxy Hybrid Networks.

    Science.gov (United States)

    Carioscia, Jacquelyn A; Stansbury, Jeffrey W; Bowman, Christopher N

    2007-03-08

    The development of thiol-ene/thiol-epoxy hybrid networks offers the advantage of tailorable polymerization kinetics while producing a highly crosslinked, high T(g) polymer that has significantly reduced shrinkage stress. Stoichiometric mixtures of pentaerythritol tetra(3-mercaptopropionate) (PETMP)/triallyl-1,3,5-triazine-2,4,6-trione (TATATO) (thiol-ene, mixture 1) and PETMP/bisphenol a diglycidyl ether (BADGE) (thiol-epoxy, mixture 2) were prepared and hybrid mixtures of 75/25, 50/50, 25/75, and 10/90 w/w of mixtures 1 and 2 were polymerized using a combination of both radical and anionic initiation. The light exposure timing and the relative initiation conditions of the two types were used to control the order and relative rates of the radical and anionic polymerizations. The 50/50 w/w thiol-ene/thiol-epoxy hybrid material exhibited a final stress of only 0.2 MPa, which is 90 % lower than the stress developed in a control dimethacrylate resin. Kinetic analysis indicates composition affects network development in thiol-ene/thiol-epoxy hybrid networks and produces materials with robust mechanical properties.

  13. Patterned Hydrophilization of Nanoporous 1,2‐PB by Thiol‐ene Photochemistry

    DEFF Research Database (Denmark)

    Berthold, Anton; Sagar, Kaushal Shashikant; Ndoni, Sokol

    2011-01-01

    We present an efficient method for functionalizing the large polymer–air interface of a gyroid nanoporous polymer. The hydrophilicity of nanoporous cross‐linked 1,2‐polybutadiene is tuned by thiol‐ene photo‐grafting of mercaptosuccinic acid or sodium 2‐mercaptoethanesulfonate. The reaction...

  14. Mait Agu nimelise stipendiumi pälvivad aastal 2013 Eliisa Sokk ja Ene Jakobson

    Index Scriptorium Estoniae

    2013-01-01

    Tallinna Ülikooli koreograafia osakond annab Mait Agu nimelist stipendiumi välja viieteistkümnendat korda. Stipendiumi saavad TLÜ koreograafia osakonna 3. kursuse tudeng Eliisa Sokk ja TLÜ koreograafia eriala 2. lennu lõpetaja, tantsuansambli "Sõleke" looja ning juht Ene Jakobson

  15. Orented immobilization of farnesylated proteins by the thiol-ene reaction

    NARCIS (Netherlands)

    Weinrich, Dirk; Lin, Po-Chiao; Jonkheijm, Pascal; Nguyen, Uyen T.T.; Schröder, Hendrik; Niemeyer, Christof M.; Alexandrov, Kirill; Goody, Roger; Waldmann, Herbert

    2010-01-01

    Anchoring the protein: Proteins were immobilized rapidly under mild conditions by thiol-ene photocoupling between S-farnesyl groups attached to a genetically encodable “CAAX-box” tetrapeptide sequence (A is aliphatic) at the C terminus of the protein and surface-exposed thiols (see scheme). This

  16. Heat- and light-induced thiol-ene oligomerization of soybean oil-based polymercaptan

    Science.gov (United States)

    Polymercaptanized soybean oil (PMSO), the product of a thiol-ene reaction between soybean oil and hydrogen sulfide, is a material of interest as a lubricant additive and polymer precursor. We investigated with gel permeation chromatography, nuclear magnetic resonance (one-dimensional and two-dimensi...

  17. DFT Investigation of the Palladium-Catalyzed Ene-Yne Coupling

    DEFF Research Database (Denmark)

    Henriksen, Signe Teuber; Tanner, David Ackland; Skrydstrup, T.

    2010-01-01

    The mechanism of the recently developed palladium-catalyzed ene-yne coupling has been evaluated by DFT methods. The calculations validate the previously proposed reaction mechanism and explain the stereoselectivity of the reaction (exclusive formation of the E isomer of the disubstituted alkene)....

  18. Isolation and Characterization of Lup-20(29)-ene-3, 28- diol (Betulin ...

    African Journals Online (AJOL)

    Recrystallization was used to further purify the isolated compound. Characterization of the isolated compound was by melting point, as well as by 1H and 13C nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS). Results: A triterpenoid (lup-20(29)-ene-3, 28-diol), commonly known as betulin, was ...

  19. Rapid photochemical surface patterning of proteins in thiol-ene based microfluidic devices

    DEFF Research Database (Denmark)

    Lafleur, Josiane P.; Kwapiszewski, Radoslaw; Jensen, Thomas Glasdam

    2013-01-01

    ! 17 SH nm"2. Biotin alkyne was patterned directly inside thiol–ene microchannels prior to conjugation with fluorescently labelled streptavidin. The surface bound conjugates were detected by evanescent waveinduced fluorescence (EWIF), demonstrating the success of the grafting procedure and its...

  20. Rapid photochemical surface patterning of proteins in thiol-ene based microfluidic devices

    DEFF Research Database (Denmark)

    Lafleur, Josiane P.; Kwapiszewski, Radoslaw; Jensen, Thomas Glasdam

    2012-01-01

    ” and “ene” monomers present in the microfluidic chip bulk material provides a simple and efficient way of tuning the chip’s surface chemistry. Here, thiol-ene chips displaying an excess of functional thiol groups at their surfaces are functionalized with biotin and streptavidin in a controlled fashion using...

  1. Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis

    KAUST Repository

    Baumgartner, Corinne

    2010-01-01

    Our efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted S N2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention of stereochemistry. © 2010 The Royal Society of Chemistry.

  2. Development of Thermal and Photochemical Strategies for Thiol−Ene Click Polymer Functionalization

    NARCIS (Netherlands)

    Campos, Luis M.; Killops, Kato L.; Sakai, Ryosuke; Paulusse, Jos Marie Johannes; Damiron, Denis; Drockenmuller, Eric; Messmore, Benjamin W.; Hawker, Craig J.

    2008-01-01

    A series of alkene-functional polymers were synthesized by controlled polymerization techniques in order to investigate and compare the efficiency and orthogonality of both photochemically and thermally initiated thiol−ene click coupling reactions. The copolymers were designed to have single or

  3. A Study of Functional Polymer Colloids Prepared Using Thiol-Ene/Yne Click Chemistry

    Science.gov (United States)

    Durham, Olivia Z.

    This project demonstrates the first instance of thiol-ene chemistry as the polymerization method for the production of polymer colloids in two-phase heterogeneous suspensions, miniemulsions, and emulsions. This work was also expanded to thiol-yne chemistry for the production of polymer particles containing increased crosslinking density. The utility of thiol-ene and thiol-yne chemistries for polymerization and polymer modification is well established in bulk systems. These reactions are considered 'click' reactions, which can be defined as processes that are both facile and simple, offering high yields with nearly 100% conversion, no side products, easy product separation, compatibility with a diverse variety of commercially available starting materials, and orthogonality with other chemistries. In addition, thiol-ene and thiol-yne chemistry follow a step-growth mechanism for the development of highly uniform polymer networks, where polymer growth is dependent on the coupling of functional groups. These step-growth polymerization systems are in stark contrast to the chain-growth mechanisms of acrylic and styrenic monomers that have dominated the field of conventional heterogeneous polymerizations. Preliminary studies evaluated the mechanism of particle production in suspension and miniemulsion systems. Monomer droplets were compared to the final polymer particles to confirm that particle growth occurred through the polymerization of monomer droplets. Additional parameters examined include homogenization energy (mechanical mixing), diluent species and concentration, and monomer content. These reactions were conducted using photoinitiation to yield particles in a matter of minutes with diameters in the size range of several microns to hundreds of microns in suspensions or submicron particles in miniemulsions. Improved control over the particle size and size distribution was examined through variation of reaction parameters. In addition, a method of seeded suspension

  4. Functionalization of embedded thiol-ene waveguides for evanescent wave-induced fluorescence detection in a microfluidic device

    DEFF Research Database (Denmark)

    Feidenhans, Nikolaj A.; Jensen, Thomas Glasdam; Lafleur, Josiane P.

    2013-01-01

    functionalized with biotin using photografting. The biotin was used for immobilization of fluorescently labelled streptavidin, and experiments revealed a linear correlation between streptavidin concentration and fluorescent intensity. To further demonstrate the attractiveness of using thiol-ene for optofluidic...

  5. Functionalization of embedded thiol-ene waveguides for evanescent wave induced fluorescence detection in a microfluidic device

    DEFF Research Database (Denmark)

    Feidenhans'l, Nikolaj Agentoft; Jensen, Thomas Glasdam; Lafleur, Josiane P.

    2013-01-01

    functionalized with biotin using photografting. The biotin was used for immobilization of fluorescently labelled streptavidin, and experiments revealed a linear correlation between streptavidin concentration and fluorescent intensity. To further demonstrate the attractiveness of using thiol−ene for optofluidic...

  6. Ene-Liis Semper : Kohalolu piiritsoonis = Presence in the border zone / Anu Allas

    Index Scriptorium Estoniae

    Allas, Anu, 1977-

    2007-01-01

    Teatri- ja videokunstnik Ene-Liis Semperi peamiselt 1990-ndate aastate videotest, mis on valdavalt rõhutatult lavastuslikud, paisutatult sümbolistlikud või kus on esitatud piirsituatsioone, ahistust ning selle teadlikku eksponeerimist väljakutsena publikule. Iseennast paljastades, alandades ja ohtu seades jääb kunstnik enamasti jahedalt distantseerituks, publikule jääb aga arusaamatuks, kas tegemist on ohvri, kangelanna või osava mänguriga

  7. Simple Preparation of Thiol-Ene Particles in Glycerol and Surface Functionalization by Thiol-Ene Chemistry (TEC) and Surface Chain Transfer Free Radical Polymerization (SCT-FRP).

    Science.gov (United States)

    Hoffmann, Christian; Chiaula, Valeria; Yu, Liyun; Pinelo, Manuel; Woodley, John M; Daugaard, Anders E

    2018-01-01

    Thiol-ene (TE)-based polymer particles are traditionally prepared via emulsion polymerization in water (using surfactants, stabilizers, and cosolvents). Here, a green and simple alternative is presented with excellent control over particle size, while avoiding the addition of stabilizers. Glycerol is applied as a dispersing medium for the preparation of off-stoichiometric TE microparticles, where sizes in the range of 40-400 µm are obtained solely by changing the mixing speed of the emulsions prior to crosslinking. Control over surface chemistry is achieved by surface functionalization of excess thiol groups via photochemical thiol-ene chemistry resulting in a functional monolayer. In addition, surface chain transfer free radical polymerization is used for the first time to introduce a thicker polymer layer on the particle surface. The application potential of the system is demonstrated by using functional particles as adsorbent for metal ions and as a support for immobilized enzymes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Thiol-ene reaction as tool for crosslinking of polynorbornene micelles in the nanoscale

    Science.gov (United States)

    Rupp, Barbara; Bauer, Thomas; Slugovc, Christian

    2009-08-01

    The thiol-ene reaction is a established photoreaction of multifunctional thiols and enes. Virtually any type of ene will participate in a free radical polymerisation process with a thiol. An advantage over many other photochemical reactions is that the reaction proceeds almost as rapidly in ambient conditions as in inert atmosphere. In this work we introduce the UV-crosslinking of polynorbornenes made by ring opening metathesis polymerization making use of the residual double bond in the polymer backbone. The crosslinking experiments were done in thin films and were followed by FTIR measurements, to proof the accessibility of double-bonds in the polymers for the addition of the thiols. As a result of these pre-experiments we created flexible and light transmitting films. To further increase the scope of this reaction, amphiphilic block copolymers were prepared and used to form block copolymer micelles in a selective solvent, which were subsequently crosslinked with pentaerythritol tetra(3-mercaptopropionate) (PETMP). FT-IR, DLS and SEM-measurements were used to prove the successful crosslinking and thus nanoparticle formation.

  9. Superhydrophobic hybrid inorganic-organic thiol-ene surfaces fabricated via spray-deposition and photopolymerization.

    Science.gov (United States)

    Sparks, Bradley J; Hoff, Ethan F T; Xiong, Li; Goetz, James T; Patton, Derek L

    2013-03-13

    We report a simple and versatile method for the fabrication of superhydrophobic inorganic-organic thiol-ene coatings via sequential spray-deposition and photopolymerization under ambient conditions. The coatings are obtained by spray-deposition of UV-curable hybrid inorganic-organic thiol-ene resins consisting of pentaerythritol tetra(3-mercaptopropionate) (PETMP), triallyl isocyanurate (TTT), 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane (TMTVSi), and hydrophobic fumed silica nanoparticles. The spray-deposition process and nanoparticle agglomeration/dispersion provide surfaces with hierarchical morphologies exhibiting both micro- and nanoscale roughness. The wetting behavior, dependent on the concentration of TMTVSi and hydrophobic silica nanoparticles, can be varied over a broad range to ultimately provide coatings with high static water contact angles (>150°), low contact angle hysteresis, and low roll off angles (<5°). The cross-linked thiol-ene coatings are solvent resistant, stable at low and high pH, and maintain superhydrophobic wetting behavior after extended exposure to elevated temperatures. We demonstrate the versatility of the spray-deposition and UV-cure process on a variety of substrate surfaces including glass, paper, stone, and cotton fabric.

  10. Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations.

    Science.gov (United States)

    Steinkellner, Georg; Gruber, Christian C; Pavkov-Keller, Tea; Binter, Alexandra; Steiner, Kerstin; Winkler, Christoph; Lyskowski, Andrzej; Schwamberger, Orsolya; Oberer, Monika; Schwab, Helmut; Faber, Kurt; Macheroux, Peter; Gruber, Karl

    2014-06-23

    The exploitation of catalytic promiscuity and the application of de novo design have recently opened the access to novel, non-natural enzymatic activities. Here we describe a structural bioinformatic method for predicting catalytic activities of enzymes based on three-dimensional constellations of functional groups in active sites ('catalophores'). As a proof-of-concept we identify two enzymes with predicted promiscuous ene-reductase activity (reduction of activated C-C double bonds) and compare them with known ene-reductases, that is, members of the Old Yellow Enzyme family. Despite completely different amino acid sequences, overall structures and protein folds, high-resolution crystal structures reveal equivalent binding modes of typical Old Yellow Enzyme substrates and ligands. Biochemical and biocatalytic data show that the two enzymes indeed possess ene-reductase activity and reveal an inverted stereopreference compared with Old Yellow Enzymes for some substrates. This method could thus be a tool for the identification of viable starting points for the development and engineering of novel biocatalysts.

  11. Thiol-Ene Based Polymer Waveguides Fabricated By Uv-Assisted Soft Lithography For Optofluidic Applications

    DEFF Research Database (Denmark)

    Zhuang, Guisheng; Jensen, Thomas Glasdam; Kutter, Jörg Peter

    2011-01-01

    In this paper, a thiol-ene based polymer waveguide, defined by UV-assisted soft lithography, is designed, fabricated and characterized. Waveguides are formed by filling microfluidic channels with a high refractive index liquid mixture of ‘thiol’ and ‘ene’ monomers (e.g., trimethylolpropane tris(3...... thiol-ene based polymers as waveguide core materials for potential optofluidic applications.......In this paper, a thiol-ene based polymer waveguide, defined by UV-assisted soft lithography, is designed, fabricated and characterized. Waveguides are formed by filling microfluidic channels with a high refractive index liquid mixture of ‘thiol’ and ‘ene’ monomers (e.g., trimethylolpropane tris(3......-mercaptopropionate) = ‘thiol’, and 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione = ‘ene’), which can be cured by UV exposure into a solid polymer. The waveguides demonstrated good confinement of light, and a propagation loss of 0.5 dB/cm was obtained. To our best knowledge, this is the first report to employ...

  12. Antibiofouling hybrid dendritic Boltorn/star PEG thiol-ene cross-linked networks.

    Science.gov (United States)

    Bartels, Jeremy W; Imbesi, Philip M; Finlay, John A; Fidge, Christopher; Ma, Jun; Seppala, Jonathan E; Nystrom, Andreas M; Mackay, Michael E; Callow, James A; Callow, Maureen E; Wooley, Karen L

    2011-06-01

    A series of thiol-ene generated amphiphilic cross-linked networks was prepared by reaction of alkene-modified Boltorn polyesters (Boltorn-ene) with varying weight percent of 4-armed poly(ethylene glycol) (PEG) tetrathiol (0-25 wt%) and varying equivalents of pentaerythritol tetrakis(3-mercaptopropionate) (PETMP) (0-64 wt%). These materials were designed to present complex surface topographies and morphologies, with heterogeneity of surface composition and properties and robust mechanical properties, to serve as nontoxic antibiofouling coatings that are amenable to large-scale production for application in the marine environment. Therefore, a two-dimensional matrix of materials compositions was prepared to study the physical and mechanical properties, over which the compositions spanned from 0 to 25 wt% PEG tetrathiol and 0-64 wt% PETMP (the overall thiol/alkene (SH/ene) ratios ranged from 0.00 to 1.00 equiv), with both cross-linker weight percentages calculated with respect to the weight of Boltorn-ene. The Boltorn-ene components were prepared through the esterification of commercially available Boltorn H30 with 3-butenoic acid. The subsequent cross-linking of the Boltorn-PEG-PETMP films was monitored using IR spectroscopy, where it was found that near-complete consumption of both thiol and alkene groups occurred when the stoichiometry was ca. 48 wt% PETMP (0.75 equiv SH/ene, independent of PEG amount). The thermal properties of the films showed an increase in T(g) with an increase in 4-armed PEG-tetrathiol wt%, regardless of the PETMP concentration. Investigation of the bulk mechanical properties in dry and wet states found that the Young's modulus was the greatest at 48 wt% PETMP (0.75 equiv of SH/ene). The ultimate tensile strength increased when PETMP was constant and the PEG concentration was increased. The Young's modulus was slightly lower for wet films at constant PEG or constant PETMP amounts, than for the dry samples. The nanoscopic surface features were

  13. Investigations of step-growth thiol-ene polymerizations for novel dental restoratives.

    Science.gov (United States)

    Lu, Hui; Carioscia, Jacquelyn A; Stansbury, Jeffery W; Bowman, Christopher N

    2005-12-01

    The goal of this work was to investigate the feasibility of formulating novel dental restorative materials that utilize a step-growth thiol-ene photopolymerization. Particularly, we are aiming to significantly reduce the polymerization shrinkage and shrinkage stress while retaining adequate physical properties as compared to current dimethacrylatre-based systems. The thiol-ene system is composed of a 4:3 molar mixture of triallyl-1,3,5-triazine-2,4,6-trione (TATATO) and pentaerythritol tetramercaptopropionate (PETMP). The simultaneous measurement of shrinkage stress and functional group conversion was performed. Solvent extraction of unreacted monomers and dynamic mechanical analysis on the polymer networks that were formed were also studied. Flexural strength was measured for both filled and unfilled PETMP/TATATO and Bis-GMA/TEGDMA systems. Photopolymerization of PETMP/TATATO occurs at a much higher rate, with the maximum polymerization rate six times faster, than Bis-GMA/TEGDMA cured under the identical conditions. The results from the simultaneous measurement of shrinkage stress and conversion showed that the onset of shrinkage stress coincides with the delayed gel point conversion, which is predicted to be 41% for the 3:4 stoichiometric PETMP/TATATO resin composition. The maximum shrinkage stress developed for PETMP/TATATO was about 0.4 MPa, which was only approximately 14% of the maximum shrinkage stress of the Bis-GMA/TEGDMA system. Adequate flexural strength and flexural modulus values were obtained for both filled and unfilled PETMP/TATATO systems. The dramatically reduced shrinkage stress, increased polymerization rate, significance increased functional group conversion, and decreased leachable species are all benefits for the use-of thiol-ene systems as potential dental restorative materials.

  14. Steroid dimer formation: metal reduction of methyl androst-4-ene-3, 17-dion-19-oate.

    Science.gov (United States)

    Templeton, J F; Majgier-Baranowska, H; Marat, K

    2000-04-01

    Two isomeric dimeric steroids, 3,3'-bis(methyl 3-hydroxyandrost-4-en-17-on-19-oate-3-yl), with symmetrical (alpha, alpha') and unsymmetrical structures (alpha,beta'), have been obtained by reduction of methyl androst-4-ene-3,17-dion-19-oate with zinc in aqueous acetic acid together with the major products, the isomeric methyl 5alpha- and 5beta-androst-3-en-17-on-19-oates. The structures of the dimers and unsaturated products are supported by spectroscopic methods. The symmetrical dimer was also obtained from treatment of the 4-en-3-on-19-oate ester with lithium in ammonia.

  15. Synthesis and characterization of thiol-ene functionalized siloxanes and evaluation of their polymerization kinetics, network properties, and dental applications

    Science.gov (United States)

    Cole, Megan A.

    We explored formation-structure-property relationships in thiol-ene functionalized oligosiloxanes to create crosslinked networks. Specifically, nine oligomers were synthesized, three with thiol-functional silane repeats and three with allyl-functional silane repeats. Structural variations in each oligomer were systematically induced through the incorporation of non-reactive repeats bearing either diphenyl or di-n-octyl moieties, and the oligomer molecular weight was limited by the presence of monofunctional silane condensation species. The molecular weights and chain compositions of all oligomers were ascertained and subsequently used in the evaluation of network properties formed upon photopolymerization of thiol- and ene-functional reactants. Polymerization kinetics of the thiol-ene functionalized siloxanes were also investigated using photoinitiation owing to the spatial and temporal control afforded by this technique. In particular, the effects of the viscosity of the ene-functionalized oligomer and the degree of thiol functionalization on the observed polymerization rate were determined. Results showed that the speed of polymerization varied with changes to the rate-limiting step, which was heavily influenced by neighboring non-reactive functionalities. Moreover, the thiol-ene reaction was found to exhibity unimolecular termination exclusively in siloxane-based systems. Proposed use of the thiol-ene functionalized siloxane system as a dental impression material necessitated the development of a redox initiation scheme. Evaluation of the benzoylperoxide/dimethyl-p-toluidine redox pair in traditional systems showed bulk thiol-ene polymerizations comparable to photoinitiation with the added advantage of uninhibited depth control, as also demonstrated in small molecule thiol-ene coupling reactions initiated by this same redox system. Application of the redox pair to the siloxane system allowed for the viscoelastic properties as well as the feature replication

  16. Photopolymerized cross-linked thiol-ene polyanhydrides: erosion, release, and toxicity studies.

    Science.gov (United States)

    Poetz, Katie L; Mohammed, Halimatu S; Snyder, Brittany L; Liddil, Garrett; Samways, Damien S K; Shipp, Devon A

    2014-07-14

    Several critical aspects of cross-linked polyanhydrides made using thiol-ene polymerization are reported, in particular the erosion, release, and solution properties, along with their cytotoxicity toward fibroblast cells. The monomers used to synthesize these polyanhydrides were 4-pentenoic anhydride and pentaerythritol tetrakis(3-mercaptopropionate). Techniques used to evaluate the erosion mechanism indicate a complex situation in which several phenomena, such as hydrolysis rates, local pH, water diffusion, and solubility, may be influencing the erosion process. The mass loss profile, the release rate of a hydrophilic dye, the rate of hydrolysis of the polyanhydride, the hydrolysis product solubility as a function of pH, average pK(a) and its cytotoxicity toward fibroblast cells were all determined. The solubility of the degradation product is low at pH values less than 6-7, and the average pKa was determined to be ~5.3. The cytotoxicity of the polymer and the degradation product was found to be low, with cell viabilities of >97% for the various samples studied at concentrations of ~1000-1500 ppm. These important parameters help determine the potential of the thiol-ene polyanhydrides in various biomedical applications. These polyanhydrides can be used as a delivery vehicle, and although the release profile qualitatively followed the mass loss profile for a hydrophilic dye, the release rate appears to be by both diffusion and mass loss mechanisms.

  17. Self-Healing Photocurable Epoxy/thiol-ene Systems Using an Aromatic Epoxy Resin

    Directory of Open Access Journals (Sweden)

    Ricardo Acosta Ortiz

    2016-01-01

    Full Text Available A rapid and efficient method to obtain self-healing epoxy resins is discussed. This method is based on the use of a thiol-disulfide oligomer obtained by partial oxidation of a multifunctional thiol using a hypervalent iodine (III compound as oxidant. The oligomer was characterized by Fourier transform infrared spectroscopy (FTIR, Raman and nuclear magnetic resonance spectroscopies, and gel permeation chromatography (GPC. The oligomer was a joint component of the thiol-ene system along with a tetra-allyl-functionalized curing agent. The kinetics of the photopolymerization of diglycidylether of bisphenol A (DGEBA revealed that conversions of the epoxy groups as high as 80% were achieved in only 15 minutes by increasing the concentration of the thiol-ene system in the formulation. The disulfide bonds introduced in the copolymer using the thiol-disulfide oligomer allowed the repairing of the test specimens in as little as 10 minutes when the specimens were heated at 80°C or for 500 minutes at room temperature. The analysis of the mechanical properties using dynamic mechanical analysis (DMA showed that the specimens displayed a healing efficiency up to 111% compared with the unhealed specimens, depending on the amount of polythioethers present in the copolymer.

  18. Luuletus Halbdeutschis ja mõned küsimused substraadi kohta / Ilse Lehiste ; tlk. Ene-Reet Soovik

    Index Scriptorium Estoniae

    Lehiste, Ilse, 1922-2010

    2000-01-01

    Jacob Johann Malmi poolsaksakeelne satiiriline luuletus "Die Oberpalsche Freundschaft" aastast 1818 - luuletuse substraatkeelte eesti ja baltisaksa vokaalide ja konsonantsüsteemi ning grammatilise struktuuri võrdlus. Ilmunud: A poem in Halbdeutsch and some questions concerning substratum // Word 21, 1965, lk. 55-69. Tõlk. Ene-Reet Soovik

  19. Kas erivajadustega lapsed saavad õigel ajal abi? / Ene Mägi, Urve Raudsepp-Alt, Ale Sprenk, Peeter Aas

    Index Scriptorium Estoniae

    2009-01-01

    Küsimusele vastavad: Tallinna Ülikooli Kasvatusteaduste Instituudi eri- ja sotsiaalpedagoogika osakonna juhataja Ene Mägi, Tallinna Haridusameti üldhariduse osakonna peaspetsialist Urve Raudsepp-Alt, Krabi põhikooli direktor Ale Sprenk, Põlva Maavalitsuse haridus-, kultuuri- ja sotsiaalosakonna juhataja Peeter Aas

  20. Mida teie oma tervise heaks teete? / Ly Jagor, Ülle Mihhailova, Ene Pill, Katrin Käbin...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad Pärnu Õppenõustamiskeskuse psühholoog Ly Jagor, Maasika lasteaia juhataja asetäitja Ülle Mihhailova, Tallinna Perekeskuse ja Tähetorni lastekeskuse psühholoog Ene Pill, Tallinna Nõmme Noortemaja väikelaste ringijuht Katrin Käbin, Tääksi Põhikooli õpetaja Silva Kolk

  1. Koolirõõmuta kool on lapsele kui sunnitöö / Ene-Silvia Sarv ; intervjueerinud Karin Klaus

    Index Scriptorium Estoniae

    Sarv, Ene-Silvia, 1945-

    2013-01-01

    Intervjuu Pärnus hariduskonverentsil "Õnnelik õpilane, õnnelik õpetaja" esinenud Tallinna ülikooli lektori Ene-Silvia Sarvega, kes rääkis oma ettekandes, milline paistab tänapäeva kool õpilaste silme läbi ja mis mõjutab koolikliimat kõige enam

  2. Rapid and simple preparation of thiol–ene emulsion-templated monoliths and their application as enzymatic microreactors

    Czech Academy of Sciences Publication Activity Database

    Lafleur, J. P.; Senkbeil, S.; Novotný, Jakub; Nys, G.; Bøgelund, N.; Rand, K. D.; Foret, František; Kutter, J. P.

    2015-01-01

    Roč. 15, č. 10 (2015), s. 2162-2172 ISSN 1473-0197 R&D Projects: GA ČR(CZ) GBP206/12/G014 Institutional support: RVO:68081715 Keywords : thiol-enes * mictoreactor * monolith * fabrication * proteins Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 5.586, year: 2015

  3. Access to new endoperoxide derivatives by electrochemical oxidation of substituted 3-azabicyclo[4.1.0]hept-4-enes.

    Science.gov (United States)

    Nuter, Frédérick; Dimé, Abdou Khadre Djily; Chen, Cheng; Bounaadja, Lotfi; Mouray, Elisabeth; Florent, Isabelle; Six, Yvan; Buriez, Olivier; Marinetti, Angela; Voituriez, Arnaud

    2015-03-27

    A series of substituted 3-azabicyclo[4.1.0]hept-4-ene derivatives were prepared and analysed by cyclic voltammetry. Preparative aerobic electrochemical oxidation reactions were then carried out. Three original endoperoxides were isolated, characterised and subjected to antimalarial and cytotoxicity activity assays. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Inorganic-Organic Thiol-ene Coated Mesh for Oil/Water Separation.

    Science.gov (United States)

    Chen, Qiyi; de Leon, Al; Advincula, Rigoberto C

    2015-08-26

    A highly efficient mesh for oil/water separation was fabricated by using a superhydrophobic and superoleophilic coating of thiol-ene hybrid, consisting of pentaerythritol tetra(3-mercaptopropionate) (PETMP), 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane (TMTVSi), and hydrophobic fumed silica nanoparticles, via a simple two-step fabrication process. Spray deposition and UV curing photopolymerization were sequentially performed, during which solvent evaporation provides microscale roughness while nanoparticle aggregation forms nanoscale roughness. The hierarchical morphologies were stabilized after UV curing photopolymerization. High contact angle (>150°) and low roll-off angle (<5°) were achieved due to the multiscale roughness structure of the hierarchical morphologies. These coatings also have excellent chemical resistance, as well as temperature and pH stability, after curing.

  5. Thermal decomposition of lanthanides (III) and yttrium (III) solid complexes from ethyl ene diamine tetraacetic acid

    International Nuclear Information System (INIS)

    Mercadante, A.

    1991-01-01

    Solid state compounds of lanthanides (III) and yttrium derived from ethyl ene diamine tetraacetic acid were prepared from respective basic carbonates, that were neutralized with EDTA stoichiometry quantities. Complexometry with EDTA, thermogravimetry (TG), differential thermal analysis (DTA) and X-ray diffraction have been used in the study of these compounds. The results of complexometry with EDTA as well as TG and DTA curves bed to the stoichiometry of these compounds the following general formula is obeyed: H[Ln(EDTA]. n H 2 O. X-ray powder patterns of these compounds permitted to establish two isomorphous series. The DTA ant TG curves allowed us to study the dehydration process, the thermal stability and thermal decomposition of these compounds. (C.G.C.)

  6. Development of a thiol-ene based screening platform for enzyme immobilization demonstrated using horseradish peroxidase

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Pinelo, Manuel; Woodley, John

    2017-01-01

    Efficient immobilization of enzymes on support surfaces requires an exact match between the surface chemistry and the specific enzyme. A successful match would normally be identified through time consuming screening of conventional resins in multiple experiments testing individual immobilization...... strategies. In this study we present a versatile strategy that largely expands the number of possible surface functionalities for enzyme immobilization in a single, generic platform. The combination of many individual surface chemistries and thus immobilization methods in one modular system permits faster...... functionalization by thiol-ene chemistry (TEC) resulted in the formation of a functional monolayer in each well, whereas, polymer surface grafts were introduced through surface chain transfer free radical polymerization (SCT-FRP). Enzyme immobilization on the modified surfaces was evaluated by using a rhodamine...

  7. Fates of imine intermediates in radical cyclizations of N-sulfonylindoles and ene-sulfonamides

    Directory of Open Access Journals (Sweden)

    Hanmo Zhang

    2015-09-01

    Full Text Available Two new fates of imine intermediates formed on radical cyclizations of ene-sulfonamides have been identified, reduction and hydration/fragmentation. Tin hydride-mediated cyclizations of 2-halo-N-(3-methyl-N-sulfonylindoleanilines provide spiro[indoline-3,3'-indolones] or spiro-3,3'-biindolines (derived from imine reduction, depending on the indole C2 substituent. Cyclizations of 2-haloanilide derivatives of 3-carboxy-N-sulfonyl-2,3-dihydropyrroles also presumably form spiro-imines as primary products. However, the lactam carbonyl group facilitates the ring-opening of these cyclic imines by a new pathway of hydration and retro-Claisen-type reaction, providing rearranged 2-(2'-formamidoethyloxindoles.

  8. Highly stretchable thermoset fibers and nonwovens using thiol-ene photopolymerization.

    Science.gov (United States)

    Shanmuganathan, Kadhiravan; Elliot, Steven M; Lane, Austin P; Ellison, Christopher J

    2014-08-27

    In this report, we describe the preparation and characterization of a new class of thermoset fibers with high elongation and elastic recovery. Integrating UV-activated thiol-ene photopolymerization and electrospinning, we demonstrate an environmentally friendly single step approach to convert small monomeric precursor molecules into highly elastic fibers and nonwoven mats. The fibers were derived by in situ photopolymerization of a trifunctional vinyl ether monomer and a tetrafunctional thiol. Although thermosets often offer good chemical and thermal stability, these fibers also have a high average elongation at break of 62%. The elastomeric nature of these vinyl-ether based fibers can be partly attributed to their subambient Tg and partly to the cross-link density, monomer structure, and resulting network homogeneity. Nonwoven mats of these fibers were also stretchable and exhibited a much higher elongation at break of about 85%. These thermoset stretchable fibers could have potential applications as textile, biomedical, hot chemical filtration, and composite materials.

  9. ’n Leksikologiese studie van die klas adjektiewe waartoe ene behoort

    Directory of Open Access Journals (Sweden)

    F. Ponelis

    2006-07-01

    Full Text Available A lexicological study of the set of Afrikaans adjectives containing 'ene' The tiny lexicological set accounted for in the present article comprises “ene”, “loutere”, “pure”, “skone”, “suiwere”, “volle”, “reine” and “totale”. Die kinders is die “ene” ore. The kids are all ears. Die lees daarvan verskaf “loutere” plesier. Reading it provides sheer pleasure. The lexicological framework forming the basis of the discussion makes reference to lexical, syntactic and semantic features. Formal and semantic specialisation is discussed and illustrated in respect of a wide range of data. The adjectival set is defined in terms of semantic features such as the following. (i “totally, full of” Haar lirieke is die “ene” opstand en adolessente aggressie. Her lyrics are sheer revolt and adolescent aggression. (ii “nothing else than” Ek bespeur “skone” (loutere, pure, suiwere, reine, die ene verwondering op die gesigte rondom my. I noticed sheer amazement on the faces around me. Subsets within the encompassing whole are brought to light by crosscutting features, such as the combination of the definite article “die” (the with “ene” and “pure”, and the variability of the ending -e in “loutere” and “suiwere” but not in “ene” and “skone”. In conclusion, the articles dealing with “ene”, “loutere” and “pure” in the comprehensive dictionary of Afrikaans, “Woordeboek van die Afrikaanse Taal”, are subjected to critical analysis.

  10. Hydrophobic thiol-ene surfaces fabricated via plasma activation and photo polymerization

    Science.gov (United States)

    Champathet, P.; Ervithayasuporn, V.; Osotchan, T.; Dangtip, S.

    2017-09-01

    Alumina, such as glazed alumina for electrical insulator, operated in an open field subjects to a very harsh condition; resulting in lifetime shortening. Coating hydrophobic layer on alumina surface can help prolonging its lifetime. In this study, 25 ×25 mm alumina sheets were used as substrates. The hydrophobic composite polymers were prepared from (3-mercaptopropyl)trimethoxysilane(MPTMS), 2,4,6,8-tetramethyl-2,4,6,8tetravinylcyclotetra siloxane(TMTVSi), pentaerythritoltetra(3-mercaptopropionate)(PETMP), 2,2-dimethoxy-2-phe nylaceto phenone(photoinitiator) and heptadecafluorodecylmethacrylate(HEFDMA) via the thiol-ene reaction. The alumina sheets were first activated by dielectric-barrier discharge plasma to improve its adhesion. All the polymers were found to optimize at the ratio of (MPTMS:TMTVSi:PETMP:HDFDMA) to 4:2:1:2 for coating on the alumina substrate. To enhance polymerization, 2,2-dimethoxy-2-phenylaceto phenome was also used as a photoinitiator A proper mixing sequence in the thiol-ene reaction results in film with excellent surface retention after prolong soaking in solvent such as acetone. FTIR shows that S-H and C=C functional groups have significantly changed after photopolymerization and thermally cured. The static contact angle increase from mere 53.0°±1.5° of the uncoated substrate to 120.0°±1.2° after coating. SEM shows the film with clear appearance of a few-micron thick. Under AFM, the coated surface roughness was about 9.3 nm with evenly distributed spikes of a few nanometer in height. The cross-cut test also confirmed the film was very smooth and none of the square of the films detached.

  11. Hydrophobic Coatings by Thiol-Ene Click Functionalization of Silsesquioxanes with Tunable Architecture.

    Science.gov (United States)

    Dirè, Sandra; Bottone, Davide; Callone, Emanuela; Maniglio, Devid; Génois, Isabelle; Ribot, François

    2017-08-08

    The hydrolysis-condensation of trialkoxysilanes under strictly controlled conditions allows the production of silsesquioxanes (SSQs) with tunable size and architecture ranging from ladder to cage-like structures. These nano-objects can serve as building blocks for the preparation of hybrid organic/inorganic materials with selected properties. The SSQs growth can be tuned by simply controlling the reaction duration in the in situ water production route (ISWP), where the kinetics of the esterification reaction between carboxylic acids and alcohols rules out the extent of organosilane hydrolysis-condensation. Tunable SSQs with thiol functionalities (SH-NBBs) are suitable for further modification by exploiting the simple thiol-ene click reaction, thus allowing for modifying the wettability properties of derived coatings. In this paper, coatings were prepared from SH-NBBs with different architecture onto cotton fabrics and paper, and further functionalized with long alkyl chains by means of initiator-free UV-induced thiol-ene coupling with 1-decene (C10) and 1-tetradecene (C14). The coatings appeared to homogeneously cover the natural fibers and imparted a multi-scale roughness that was not affected by the click functionalization step. The two-step functionalization of cotton and paper warrants a stable highly hydrophobic character to the surface of natural materials that, in perspective, suggests a possible application in filtration devices for oil-water separation. Furthermore, the purification of SH-NBBs from ISWP by-products was possible during the coating process, and this step allowed for the fast, initiator-free, click-coupling of purified NBBs with C10 and C14 in solution with a nearly quantitative yield. Therefore, this approach is an alternative route to get sol-gel-derived, ladder-like, and cage-like SSQs functionalized with long alkyl chains.

  12. Amino acid-incorporated polymer network by thiol-ene polymerization

    Directory of Open Access Journals (Sweden)

    R. Yokose

    2015-08-01

    Full Text Available Triallyl L-alanine (A3A and triallyl L-phenylalanine (A3F were synthesized by reactions of L-alanine and L-phenylalanine with allyl bromide in the presence of sodium hydroxide, respectively. Thiol-ene thermal polymerization of A3A or A3F with pentaerythritol-based primary tetrathiol (pS4P or pentaerythritol-based secondary tetrathiol (S4P at allyl/SH 1/1 in the presence of 2,2'-azobis(isobutyronitrile produced an amino acid-incorporated polymer network (A3ApS4P, A3A-S4P or A3F-S4P. Although the thermally cured resins were homogeneous and flat films, the corresponding thiol-ene photopolymerization did not give a successful result. Degree of swelling for each thermally cured film in N,Ndimethylformamide was much higher than that in water. The glass transition and 5% weight loss temperatures (Tg and T5 of A3F-pS4P and A3F-S4P were higher than those of A3A-pS4P and A3A-S4P, respectively. Also, A3F-pS4P and A3F-S4P exhibited much higher tensile strengths and moduli than A3A-pS4P and A3A-S4P did, respectively. Consequently, A3FpS4P displayed the highest Tg (38.7°C, T5 (282.0°C, tensile strength (9.5 MPa and modulus (406 MPa among all the thermally cured resins.

  13. Support to Climate Data Dissemination in a Worldwide Data Federation by IS-ENES2

    Science.gov (United States)

    Rathmann, Torsten; Toussaint, Frank; Kindermann, Stephan; Lautenschlager, Michael

    2015-04-01

    Thousands of users accessed climate data produced as part of the Coupled Model Intercomparison Project Phase 5 (CMIP5). The data were created by about 30 different institutes and disseminated to a large variety of end users via a worldwide distributed infrastructure (Earth System Grid Federation, ESGF) consisting of data nodes and data portals. Part of the data was also used for the 5th Assessment Report of the Intergovernmental Panel on Climate Change and preserved in a long term archive. A support activity was funded within the IS-ENES2 FP7 project to support the various aspects of data dissemination for large intercomparison projects like CMIP5 and CORDEX. The activity was structured into the following parts: Support for data providers: • Development of basic data quality assurance tools, to be applied by data provider prior to making data accessible in the data federation • Support in installing and using the quality assurance tools • Agreements on best practices of data dissemination (e.g. search facets to be supported across sites etc.) Support for data users: Establishment of basic user support infrastructure components and services: • Askbot based internet forum for user support questions and answers • Support pages on central portals • Continuous maintenance of user support mailing lists Support for data centres and for fostering their collaboration: • Development of automatic consistency checking routines for data federation portals operated at different sites • Organization of data node installation and operation support events • Collection of distributed data usage statistic metrics • Development of Data Management Plans (DMP) • Activities towards common data access policies The experiences gained within the IS-ENES2 support activities will provide the basis of activities for improving the user support process in the future, especially in the context of upcoming large intercomparison projects like CMIP6, which will use the same

  14. Ene-yne Cross-Metathesis for the Preparation of 2,3-Diaryl-1,3-dienes

    Directory of Open Access Journals (Sweden)

    Meriem K. Abderrezak

    2017-11-01

    Full Text Available Ene-yne cross-metathesis from alkynes and ethylene is a useful method to produce substituted conjugated butadiene derivatives. If this method has been used with aliphatic alkynes, it has however never been used starting from diarylacetylenes as internal alkynes. We show that the ene-yne cross-metathesis catalyzed by the second generation Hoveyda ruthenium catalyst provides the 2,3-diarylbuta-1,3-dienes under 3 atm of ethylene at 100 °C. The scope and limitations of the reaction have been evaluated starting from unsymmetrical functionalized diarylacetylene derivatives hence leading to unsymmetrical 2,3-diarylbuta-1,3-dienes in a straightforward and environmentally acceptable manner.

  15. Palladium-Catalyzed Intramolecular Trost-Oppolzer-Type Alder-Ene Reaction of Dienyl Acetates to Cyclopentadienes.

    Science.gov (United States)

    Bankar, Siddheshwar K; Singh, Bara; Tung, Pinku; Ramasastry, S S V

    2018-02-05

    A new approach to the synthesis of highly substituted cyclopentadienes, indenes, and cyclopentene-fused heteroarenes by means of the Pd-catalyzed Trost-Oppolzer-type intramolecular Alder-ene reaction of 2,4-pentadienyl acetates is described. This unprecedented transformation combines the electrophilic features of the Tsuji-Trost reaction with the nucleophilic features of the Alder-ene reaction. The overall outcome can be perceived as a hitherto unknown "acid-free" iso-Nazarov-type cyclization. The versatility of this strategy was further demonstrated by the formal synthesis of paucifloral F, a resveratrol-based natural product. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. N,N′-Bis­[(E)-(6-methyl-2-pyridyl)­methyl­ene]hexane-1,6-diamine

    Science.gov (United States)

    Ramos Silva, Manuela; Silva, Joana A.; Matos Beja, Ana; Sobral, Abilio J. F.N.

    2009-01-01

    The title compound, C20H26N4, is composed of two (6-methyl-2-pyridyl)methyl­ene units linked by a 1,6-diamine hexane chain. The mol­ecule has Ci symmetry with the inversion center situated at the mid-point of the central C—C bond. The alkyl chain has an all-trans conformation, with all the non-H atoms sharing the same plane [maximum deviation 0.004 (3) Å]. The pyridylmethyl­ene groups are also planar [maximum deviation 0.009 (3) Å], making an angle of 53.78 (19)° with the hexane chain plane. In the crystal, the mol­ecules assemble in layers, stacking along the a axis. The stacks are hold together by attractive interactions between π electron systems. PMID:21583120

  17. Emplazamiento hacia el ENE del manto de Los Reales (Alpujarrides occidentales: criterios estructurales y de petrofábrica

    Directory of Open Access Journals (Sweden)

    Tubía, J. M.

    1984-08-01

    Full Text Available Los Reales nappe rests over Ojén nappe to the North of Sierra Alpujata. The nappe contact zone shows a intense plastic deformation with mylonitic rocks, The deformation decreases progressively going away from the contacto The structural study of footwall and hangingwall roen permits to attribute this deformation to the Los Reales nappe emplacement over that of Ojén. The foliation and stretching lineation distributions show a WSW-ENE shear direction. The mylonite microstructural characteristics and the enstatite crystalline preferred orientations in the basal peridotites give a mear sense in according that, Los Reales nappe is displaced, in their present position, from the WSW towards the ENE.

    El manto de Los Reales descansa sobre el manto de Ojén, al norte de Sierra Alpujata. La zona de contacto entre mantos exhibe una intensa deformación plástica con rocas miloníticas; la deformación disminuye progresivamente al alejarse del contacto. El estudio estructural de las rocas infra y suprayacentes al contacto permite atribuir esta deformación al emplazamiento del manto de Los Reales sobre el de Ojén. , Las distribuciones de la foliación y de la lineación, de estiramiento indican una dirección de cizallamiento WSW-ENE. Las características microestructurales de las milonitas y las orientaciones preferentes cristalinas de la enstatita en las peridotitas basales proporcionan un sentido de cizallamiento tal que el manto de Los Reales se ha desplazado, en su posición actual, desde el WSW hacia el ENE.

  18. ENED-GEM: A Conceptual Framework Model for Psychological Enjoyment Factors and Learning Mechanisms in Educational Games about the Environment

    Directory of Open Access Journals (Sweden)

    Kristoffer S. Fjællingsdal

    2017-06-01

    Full Text Available Based on a thorough review of psychological literature, this article seeks to develop a model of game enjoyment and environmental learning (ENvironmental EDucational Game Enjoyment Model, ENED-GEM and delineate psychological processes that might facilitate learning and inspire behavioral change from educational games about the environment. A critically acclaimed digital educational game about environmental issues (Fate of the World by Red Redemption/Soothsayer Games was used as a case study. Two hundred forty-nine reviews of the game from the popular gaming and reviewing platform known as Steam were analyzed by means of a thematic content analysis in order to identify key player enjoyment factors believed to be relevant to the process of learning from games, as well as to gain an understanding of positive and negative impressions about the game’s general content. The end results of the thematic analysis were measured up to the suggested ENED-GEM framework. Initial results generally support the main elements of the ENED-GEM, and future research into the importance of these individual core factors is outlined.

  19. Roll-to-plate fabrication of microfluidic devices with rheology-modified thiol-ene resins

    International Nuclear Information System (INIS)

    Senkbeil, Silja; Aho, Johanna; Rantanen, Jukka; Lafleur, Josiane P; Kutter, Jörg P; Yde, Leif; Lindvold, Lars R; Stensborg, Jan F

    2016-01-01

    In this paper, the replication possibilities of microfluidic channels by UV-roll-to-plate fabrication were investigated and a study of rheology-modified thiol-ene for the application in such a UV-roll-to-plate setup was conducted. The system allows the manufacture of channels with aspect ratios of 2:1 and a maximal channel depth of 90 μ m as well as the sealing of the finished devices with patterning and sealing speeds of up to 19 m min −1 . By adding fumed silica nanoparticles to the uncured resins, it was possible to alter the rheological behavior of the resin system to fabricate shallow microfluidic channels with 40  ×  95 μ m cross-sectional dimensions. Moreover, deeper (90 μ m) channels can be fabricated with highly viscous resins based on thiol-terminated oligomers. As a demonstration, capillary electrophoresis chips were prepared and tested for a simple separation of two fluorescent dyes. (paper)

  20. Inspection and monitoring plan, contaminated groundwater seeps 317/319/ENE Area, Argonne National Laboratory

    International Nuclear Information System (INIS)

    1996-01-01

    During the course of completing the Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI) in the 317/319/East-Northeast (ENE) Area of Argonne National Laboratory-East (ANL-E), groundwater was discovered moving to the surface through a series of groundwater seeps. The seeps are located in a ravine approximately 600 ft south of the ANL-E fence line in Waterfall Glen Forest Preserve. Samples of the seep water were collected and analyzed for selected parameters. Two of the five seeps sampled were found to contain detectable levels of organic contaminants. Three chemical species were identified: chloroform (14--25 microg/L), carbon tetrachloride (56--340 microg/L), and tetrachloroethylene (3--6 microg/L). The other seeps did not contain detectable levels of volatile organics. The nature of the contaminants in the seeps will also be monitored on a regular basis. Samples of surface water flowing through the bottom of the ravine and groundwater emanating from the seeps will be collected and analyzed for chemical and radioactive constituents. The results of the routine sampling will be compared with the concentrations used in the risk assessment. If the concentrations exceed those used in the risk assessment, the risk calculations will be revised by using the higher numbers. This revised analysis will determine if additional actions are warranted

  1. Iron complexes of tetramine ligands catalyse allylic hydroxyamination via a nitroso–ene mechanism

    Directory of Open Access Journals (Sweden)

    David Porter

    2015-12-01

    Full Text Available Iron(II complexes of the tetradentate amines tris(2-pyridylmethylamine (TPA and N,N′-bis(2-pyridylmethyl-N,N′-dimethylethane-1,2-diamine (BPMEN are established catalysts of C–O bond formation, oxidising hydrocarbon substrates via hydroxylation, epoxidation and dihydroxylation pathways. Herein we report the capacity of these catalysts to promote C–N bond formation, via allylic amination of alkenes. The combination of N-Boc-hydroxylamine with either FeTPA (1 mol % or FeBPMEN (10 mol % converts cyclohexene to the allylic hydroxylamine (tert-butyl cyclohex-2-en-1-yl(hydroxycarbamate in moderate yields. Spectroscopic studies and trapping experiments suggest the reaction proceeds via a nitroso–ene mechanism, with involvement of a free N-Boc-nitroso intermediate. Asymmetric induction is not observed using the chiral tetramine ligand (+-(2R,2′R-1,1′-bis(2-pyridylmethyl-2,2′-bipyrrolidine ((R,R′-PDP.

  2. Polysiloxane-based luminescent elastomers prepared by thiol-ene "click" chemistry.

    Science.gov (United States)

    Zuo, Yujing; Lu, Haifeng; Xue, Lei; Wang, Xianming; Wu, Lianfeng; Feng, Shengyu

    2014-09-26

    Side-chain vinyl poly(dimethylsiloxane) has been modified with mercaptopropionic acid, methyl 3-mercaptopropionate, and mercaptosuccinic acid. Coordinative bonding of Eu(III) to the functionalized polysiloxanes was then carried out and crosslinked silicone elastomers were prepared by thiol-ene curing reactions of these composites. All these europium complexes could be cast to form transparent, uniform, thin elastomers with good flexibility and thermal stability. The networks were characterized by FTIR, NMR, UV/Vis, and luminescence spectroscopy as well as by scanning electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy. The europium elastomer luminophores exhibited intense red light at 617 nm under UV excitation at room temperature due to the (5)D0 →(7)F2 transition in Eu(III) ions. The newly synthesized luminescent materials offer many advantages, including the desired mechanical flexibility. They cannot be dissolved or fused, and so they have potential for use in optical and electronic applications. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Risk and health of adolescents in the valley of the Apurímac, Ene and Mantaro rivers in Peru

    OpenAIRE

    Yeckting Vilela, Fabiola; Universidad Nacional Mayor de San Marcos, Lima, Perú. Antropóloga, magíster en Antropología Andina

    2017-01-01

    The article presents the diagnosis of the living conditions of male and female adolescents in the area of the valley of the Apurimac, Ene and Mantaro rivers (in Spanish: VRAEM), who are exposed to situations of risk and social and sexual vulnerability and sexual due to the high levels of coca-leaf production and the context of the illegal drug trade which create the illusion of rapid social ascent. From this, it is necessary to ask: what are the living conditions and risk situations of adoles...

  4. Vabariigi presidendi, riigikogu esimehe ja peaministri ühisavaldus 8. mail 2007 / Toomas Hendrik Ilves, Ene Ergma, Andrus Ansip

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2007-01-01

    President Toomas Hendrik Ilvese, Riigikogu spiikri Ene Ergma ja peaminister Andrus Ansipi avaldus Teise maailmasõja lõpu 62. aastapäeva puhul. Ilmunud ka: Severnoje Poberežje 9. mai 2007, lk. 2; Eesti Elu 11. mai 2007, lk. 2, pealk.: Riigijuhtide ühisavaldus Teise maailmasõja mälestuspäeval, ingl. k. lk. 11, pealk.: Joint statement May 8, 2007; ingl. k. Vaba Eesti Sõna 10. mai 2007, lk. 12, pealk.: Joint statement of the President, Speaker of the Parliament and Prime Minister of the Republic of Estonia

  5. Evaluation of fracture toughness and mechanical properties of ternary thiol-ene-methacrylate systems as resin matrix for dental restorative composites.

    Science.gov (United States)

    Beigi, Saeed; Yeganeh, Hamid; Atai, Mohammad

    2013-07-01

    Study and evaluation of fracture toughness, flexural and dynamic mechanical properties, and crosslink density of ternary thiol-ene-methacrylate systems and comparison with corresponding conventional methacrylate system were considered in the present study. Urethane tetra allyl ether monomer (UTAE) was synthesized as ene monomer. Different formulations were prepared based on combination of UTAE, BisGMA/TEGDMA and a tetrathiol monomer (PETMP). The photocuring reaction was conducted under visible light using BD/CQ combination as photoinitiator system. Mechanical properties were evaluated via measuring flexural strength, flexural modulus and fracture toughness. Scanning electron microscopy (SEM) was utilized to study the morphology of the fractured specimen's cross section. Viscoelastic properties of the samples were also determined by dynamic mechanical thermal analysis (DMTA). The same study was performed on a conventional methacrylate system. The data were analyzed and compared by ANOVA and Tukey HSD tests (significance level=0.05). The results showed improvement in fracture toughness of the specimens containing thiol-ene moieties. DMTA revealed a lower glass transition temperature and more homogenous structure for thiol-ene containing specimens in comparison to the system containing merely methacrylate monomer. The flexural modulus and flexural strength of the specimens with higher thiol-ene content were lower than the neat methacrylate system. The SEM micrographs of the fractured surface of specimens with higher methacrylate content were smooth and mirror-like (shiny) which represent brittle fracture. The thiol-ene-methacrylate system can be used as resin matrix of dental composites with enhanced fracture toughness in comparison to the methacrylate analogous. Copyright © 2013 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  6. A neutral polyacrylate copolymer coating for surface modification of thiol-ene microchannels for improved performance of protein separation by microchip electrophoresis

    DEFF Research Database (Denmark)

    Mesbah, Kiarach; Mai, T.D.; Jensen, Thomas Glasdam

    2016-01-01

    We have investigated the behavior of thiol-ene substrates that is a class of promising materials for lab-on-a-chip electrophoresis applications. Two polymeric materials were prepared by copolymerization of N, N-dimethylacrylamide (DMA), (3-(methacryloyl-oxy)propyl)trimethoxysilane (PMA) and 3......-(DMA-PMAMAPS) copolymer were evaluated in terms of surface hydrophilicity, suppression and stability of electro-osmotic flow and prevention of protein adsorption. Surface modification of thiol-ene containing a 20 % excess of thiols with the terpolymer p-(DMA-PMA-MAPS) was found to offer the most stable coating and most...

  7. Asymmetric Glyoxylate-Ene Reactions Catalyzed by Chiral Pd(II Complexes in the Ionic Liquid [bmim][PF6

    Directory of Open Access Journals (Sweden)

    Nan Sun

    2007-06-01

    Full Text Available The room temperature ionic liquid [bmim][PF6] was employed as the reactionmedium in the asymmetric glyoxylate-ene reaction of α-methyl styrene (4a with ethylglyoxylate using chiral palladium(II complexes as the catalysts. [Pd(S-BINAP(3,5-CF3-PhCN2](SbF62 (1b showed the highest catalytic activity. Under the reaction conditionsof 40 oC, 0.5 h, and 1b/4a molar ratio of 0.05, ethyl α-hydroxy-4-phenyl-4-pentenoate wasobtained in excellent chemical yield (94 % with high enantioselectivity (70 %. Otherα-hydroxy esters can also be obtained in high chemical yields and enantioselectitiesthrough the glyoxylate-ene reactions of alkenes with glyoxylates catalyzed by 1b in[bmim][PF6]. Moreover, the ionic liquid [bmim][PF6] which contained the palladium(IIcomplex could be recycled and reused several times without significant loss of the catalyticactivity.

  8. Functional characterization and stability improvement of a ‘thermophilic-like’ ene-reductase from Rhodococcus opacus 1CP

    Directory of Open Access Journals (Sweden)

    Anika eRiedel

    2015-10-01

    Full Text Available Ene-reductases are widely applied for the asymmetric synthesis of relevant industrial chemicals. A novel ene-reductase OYERo2 was found within a set of 14 putative Old Yellow Enzymes (OYEs obtained by genome mining of the actinobacterium Rhodococcus opacus 1CP. Multiple sequence alignment suggested that the enzyme belongs to the group of ‘thermophilic-like’ OYEs. OYERo2 was produced in Escherichia coli and biochemically characterized. The enzyme is strongly NADPH dependent and uses non-covalently bound FMNH2 for the reduction of activated α,β-unsaturated alkenes. In the active form OYERo2 is a dimer. Optimal catalysis occurs at pH 7.3 and 37 °C. OYERo2 showed highest specific activities (4550 U mg-1 on maleimides, which are efficiently converted to the corresponding succinimides. The OYERo2-mediated reduction of prochiral alkenes afforded the (R-products with excellent optical purity (ee > 99%. OYERo2 is not as thermo-resistant as related OYEs. Introduction of a characteristic intermolecular salt bridge by site-specific mutagenesis raised the half-life of enzyme inactivation at 32 °C from 28 min to 87 min and improved the tolerance towards organic co-solvents. The suitability of OYERo2 for application in industrial biocatalysis is discussed.

  9. Beyond PDMS: off-stoichiometry thiol-ene (OSTE) based soft lithography for rapid prototyping of microfluidic devices.

    Science.gov (United States)

    Carlborg, Carl Fredrik; Haraldsson, Tommy; Öberg, Kim; Malkoch, Michael; van der Wijngaart, Wouter

    2011-09-21

    In this article we introduce a novel polymer platform based on off-stoichiometry thiol-enes (OSTEs), aiming to bridge the gap between research prototyping and commercial production of microfluidic devices. The polymers are based on the versatile UV-curable thiol-ene chemistry but takes advantage of off-stoichiometry ratios to enable important features for a prototyping system, such as one-step surface modifications, tuneable mechanical properties and leakage free sealing through direct UV-bonding. The platform exhibits many similarities with PDMS, such as rapid prototyping and uncomplicated processing but can at the same time mirror the mechanical and chemical properties of both PDMS as well as commercial grade thermoplastics. The OSTE-prepolymer can be cast using standard SU-8 on silicon masters and a table-top UV-lamp, the surface modifications are precisely grafted using a stencil mask and the bonding requires only a single UV-exposure. To illustrate the potential of the material we demonstrate key concepts important in microfluidic chip fabrication such as patterned surface modifications for hydrophobic stops, pneumatic valves using UV-lamination of stiff and rubbery materials as well as micromachining of chip-to-world connectors in the OSTE-materials. This journal is © The Royal Society of Chemistry 2011

  10. Teatri aastaauhindade nominendid

    Index Scriptorium Estoniae

    2006-01-01

    Lavastajaauhind : Merle Karusoo, Elmo Nüganen, Tiit Ojasoo, Ene-Liis Semper, Kristian Smeds, Hendrik Toompere jun, Ingomar Vihmar ; kunstnikuauhind : Iir Hermeliin, Liina Keevallik, Ene-Liis Semper, Aime Unt, Ervin Õunapuu ; naisnäitleja auhind : Ülle Kaljuste, Kaie Mihkelson, Harriet Toompere, Marika Vaarik, Liina Vahtrik ; meesnäitleja auhind : Ain Lutsepp, Rein Oja, Rain Simmul, Tarvo Sõmer, Tambet Tuisk, Aarne Üksküla ; Balleti- ja tantsuteater : Marina Tshirkova, Seki Hirotaka, Mari Savitski, Oksana Titova, Taavet Jansen, Sasha Pepeljajev, Katrin Essenson ja Tantsuteater Fine 5

  11. Teatri aastaauhindadele kandideerijad selgunud

    Index Scriptorium Estoniae

    2006-01-01

    Lavastajaauhind : Merle Karusoo, Elmo Nüganen, Tiit Ojasoo, Ene-Liis Semper, Kristian Smeds, Hendrik Toompere jun, Ingomar Vihmar ; kunstnikuauhind : Iir Hermeliin, Liina Keevallik, Ene-Liis Semper, Aime Unt, Ervin Õunapuu ; naisnäitleja auhind : Ülle Kaljuste, Kaie Mihkelson, Harriet Toompere, Marika Vaarik, Liina Vahtrik ; meesnäitleja auhind : Ain Lutsepp, Rein Oja, Rain Simmul, Tarvo Sõmer, Tambet Tuisk, Aarne Üksküla ; Balleti- ja tantsuteater : Marina Tshirkova, Seki Hirotaka, Mari Savitski, Oksana Titova, Taavet Jansen, Sasha Pepeljajev, Katrin Essenson ja Tantsuteater Fine 5

  12. X-ray Crystal Structures and Conformational Analysis of Bicyclo[5.3.1]undec-1(11)-enes: Twisting versus Pyramidalization in Anti-Bredt Olefins

    NARCIS (Netherlands)

    Wijsman, G.W.; Iglesias, G.A.; Beekman, M.C.; De Wolf, W.H.; Bickelhaupt, F.; Kooijman, H.; Spek, A.L.

    2001-01-01

    The synthesis of several 9,11,11-trihalo[5.3.1]propellanes and their 4-dimethylsila analogues is described. They solvolyze under formation of the corresponding isomeric 7,9,11- trihalobicyclo-[5.3.1]undec-1(11)-enes which are "anti-Bredt" olefins with a strained trans double bond in a bridged

  13. X-ray crystal structures and conformational analysis of bicyclo[5.3.1]undec-1(11)-enes: twisting versus pyradidalization in anti-bredt olefins

    NARCIS (Netherlands)

    Wijsman, G.W.; Iglesias, G.A.; de Wolf, W.H.; Beekman, M.C.; Bickelhaupt, F.M.; Kooijman, H.; Spek, A.L

    2001-01-01

    The synthesis of several 9,11,11-trihalo[5.3.1]propellanes and their 4-dimethylsila analogues is described. They solvolyze under formation of the corresponding isomeric 7,9,11- trihalobicyclo-[5.3.1]undec-1(11)-enes which are "anti-Bredt" olefins with a strained trans double bond in a bridged

  14. One-step fabrication of PEGylated fluorescent nanodiamonds through the thiol-ene click reaction and their potential for biological imaging

    Science.gov (United States)

    Huang, Hongye; Liu, Meiying; Tuo, Xun; Chen, Junyu; Mao, Liucheng; Wen, Yuanqing; Tian, Jianwen; Zhou, Naigen; Zhang, Xiaoyong; Wei, Yen

    2018-05-01

    Over the past years, fluorescent carbon nanoparticles have got growing interest for biological imaging. Fluorescent nanodiamonds (FNDs) are novel fluorescent carbon nanoparticles with multitudinous useful properties, including remarkable fluorescence properties, extremely low toxicity and high refractive index. However, facile preparation of FNDs with designable properties and functions from non-fluorescent detonation nanodiamonds (DNDs) has demonstrated to be challengeable. In this work, we reported for the first time that preparation of Polyethylene glycol (PEG) functionalized FNDs through a one-step thiol-ene click reaction using thiol containing PEG (PEG-SH) as the coating agent. Based on the characterization results, we demonstrated that PEG-SH could be efficiently introduced on DNDs to obtain FNDs through the thiol-ene click chemistry. The resultant FND-PEG composites showed high water dispersibility, strong fluorescence and low cytotoxicity. Moreover, FND-PEG composites could be internalized by cells and displayed good cell dyeing performance. All of these features implied that FND-PEG composites are of great potential for biological imaging. Taken together, a facile one-step strategy based on the one-step thiol-ene click reaction has been developed for efficient preparation of FND-PEG composites from non-fluorescent DNDs. The strategy should be also useful for fabrication of many other functional FNDs via using different thiol containing compounds for the universality of thiol-ene click reaction.

  15. Ene-Liis Semper: selle aasta puhkepäevad võib ühe käe sõrmedel kokku lugeda

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2011-01-01

    Tallinna kultuuripealinna projekti panustanud Ene-Liis Semper võtab 2011. aasta sündmused kokku ja selgitab, kuidas jõudsid publiku ette suurlavastused "The Rise and Fall of Estonia", "Three Kingdoms", Põhuteater ning isikunäitus Kumus

  16. Katkenud õpingute teise kõrgkooli "kolimine" nõuab visadust / Agne Narusk, Ene Küüner, Heli Mattisen, Kadri Osula

    Index Scriptorium Estoniae

    Narusk, Agne

    2007-01-01

    Pooleli jäänud ülikooliõpingute lõpetamisest. Varasemate õpingute ja töökogemuse arvestamise tingimusi õpingute jätkamisel selgitavad Tartu Ülikooli avatud ülikooli tasemeõppe koordinaator Ene Küüner, Tallinna Ülikooli akadeemiline prorektor Heli Mattisen ja Estonian Business Schoolì õppeosakonna juhataja Kadri Osula

  17. (E-2-((4R,5R-5-((Benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-ylbut-2-ene-1,4-diol

    Directory of Open Access Journals (Sweden)

    Carlos R. Carreras

    2010-04-01

    Full Text Available The synthesis of (E-2-((4R,5R-5-((benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-ylbut-2-ene-1,4-diol by a one-step reduction of the appropriate 2-substituted butenolide is reported. Product characterization was carried out by IR, 1H NMR, 13C NMR, MS, elemental analysis and optical rotation.

  18. Facile synthesis of linear-dendritic cholesteryl-poly(epsilon-caprolactone)-b-(L-lysine)(G2) by thiol-ene and azide-alkyne "click" reactions

    DEFF Research Database (Denmark)

    Javakhishvili, Irakli; Binder, W.H.; Tanner, S.

    2010-01-01

    The construction of a linear-dendritic block copolymer consisting of terminal cholesteryl moiety, poly(epsilon-caprolactone), and a second generation L-lysine dendron has been accomplished by the combination of copper(I) catalyzed azide-alkyne and UV-triggered thiol-ene "click" reactions. Ring-op...

  19. Kui oluliseks isikuandmete kaitsmist kooli oludes peate ja millest seda tehes lähtute? / Harri Kõo, Ene Tannberg, Kalle Niinas, Maria Tiro...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad Tabasalu Ühisgümnaasiumi direktor Harri Kõo, Tartu Miina Härma Gümnaasiumi direktor Ene Tannberg, Jakob Westholmi Gümnaasiumi direktor Kalle Niinas, Jüri Gümnaasiumi direktor Maria Tiro ja Viimsi Keskkooli direktor Leelo Tiisvelt

  20. Broadening the scope of Baeyer-Villiger monooxygenase activities toward α,β-unsaturated ketones: a promising route to chiral enol-lactones and ene-lactones.

    Science.gov (United States)

    Reignier, T; de Berardinis, V; Petit, J-L; Mariage, A; Hamzé, K; Duquesne, K; Alphand, V

    2014-07-25

    Three regiodivergent Baeyer-Villiger mono-oxygenases (enantioselectively) oxidized a series of cyclic α,β-unsaturated ketones into (chiral) either enol-lactones or ene-lactones. An easy-to-use and efficient biocatalytic process based on a host-microorganism deprived of unwanted activities (knock-out mutant) was developed to enable the exclusive synthesis of unsaturated lactones.

  1. Synthesis of Ene-ynamide Derivatives Starting from Baylis-Hillman Adducts: Isomerization with the Aid of π-Cation Interaction

    Energy Technology Data Exchange (ETDEWEB)

    Gowrisankar, Saravanan; Lee, Ka Young; Kim, Seung Chan; Kim, Jae Nyoung [Chonnam National University, Gwangju (Korea, Republic of)

    2005-09-15

    We prepared some ene-ynamides starting from the Baylis-Hillman adducts. During the investigations, we found that π-cation interactions could increase the acidity of the nearby protons of triple bond of non-conjugated ene-ynamide and could make come true the isomerization into a more stable conjugated ene-ynamide form. Recently, we have developed a facile synthetic method of 9-phenyl-7H-benzocycloheptene derivatives from the alkynyl moiety-containing Baylis-Hillman adducts, which involved intramolecular Friedel-Crafts alkenylation reaction of triple bond-tethered methyl cinnamates. We also reported the synthesis of iodoenol lactones from the same substrates via the typical iodolactonization protocol. During the investigation we envisaged that we could prepare the corresponding lactam derivatives from the acetates of the Baylis-Hillman adducts by using similar strategy as shown in Scheme 1. However, during the investigation for the synthesis of lactam derivatives from, we found the formation of isomerized conjugated ene-ynamide derivatives unexpectedly and wish to report herein the results.

  2. Joint statement of the President, Speaker of the Riigikogu and Prime Minister of the Republic of Estonia / Toomas Hendrik Ilves, Ene Ergma, Andrus Ansip

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    President Toomas Hendrik Ilvese, Riigikogu spiikri Ene Ergma ja peaminister Andrus Ansipi ühisavaldus Teise maailmasõja lõpu 62. aastapäeva puhul 8. mail 2007, milles kinnitatakse, et hoolimata Teise maailmasõja ajaloolistest tõlgendustest on kõik Eestis elavad inimesed vabad ning jagavad ühist tulevikku

  3. N-(3,4-Dimethoxyphenyl-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-1-carboxamide Hydrochloride

    Directory of Open Access Journals (Sweden)

    Seranthimata Samshuddin

    2012-08-01

    Full Text Available A simple and novel route for synthesis of new spirocyclic amide derivative is developed. The present work involves the oxidative cleavage of tert-butyl 1-(furan-2-yl-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-7-carboxylate 1 followed by the amine coupling and deprotection of Boc.

  4. 1,25-(OH)2-16ene-23yne-D3 reduces secondary hyperparathyroidism in uremic rats with little calcemic effect.

    Science.gov (United States)

    Lippuner, Kurt; Perrelet, Romain; Casez, Jean-Paul; Popp, Albrecht; Uskokovic, Milan R; Jaeger, Philippe

    2004-01-01

    To compare the effects of vitamin D analogs versus calcitriol on serum levels of Ca, P and parathyroid hormone (PTH). A compound better than calcitriol should increase the Ca x P product less than calcitriol for an equivalent decrease in PTH levels. Biological activity of 4 vitamin D analogs, 1,25-(OH)(2)-16ene- D(3) (RO(1)), 1,25-(OH)(2)-16ene-23yne-D(3) (RO(2)), 1,25-(OH)(2)-26,27-hexafluoro-16ene-23yne-D(3) (RO(3)) and 1,25-(OH)(2)-16ene-23yne-26,27-hexafluoro-19nor-D(3) (RO(4)) was tested vs. calcitriol in parathyroidectomized rats. In a second set of experiments, the effects of RO(2), RO(4) and calcitriol were studied in 5/6 nephrectomized rats with secondary hyperparathyroidism. In parathyroidectomized rats, all analogs (250 pmol/day) led calcemia to rise after 7 days. In uremic rats, all treatments reduced PTH levels. RO(4) revealed toxicity. RO(2) was as effective as calcitriol in suppressing PTH in a dose dependent manner. Mean plasma ionized calcium did not change from baseline to day 14 and day 28 on RO(2) (250 or 500 pmol/day) whereas it increased significantly on RO(2) (1,000 pmol/day) and calcitriol (125 or 250 pmol/day). Increasing the dose of calcitriol led Ca x P to rise more dramatically than increasing the dose of RO(2), which appears to have a wider therapeutic window than calcitriol. 1,25-(OH)(2)-16ene-23yne-D(3) (RO(2)) may represent a novel candidate for the treatment of renal osteodystrophy in humans. Copyright 2004 S. Karger AG, Basel

  5. The preparation and physical properties of polysulfide-based elastomers through one-pot thiol-ene click reaction

    Directory of Open Access Journals (Sweden)

    Y. W. Quan

    2013-07-01

    Full Text Available In this paper, polysulfide-based elastomers were successfully prepared through a simple one-pot thiol-ene click reaction of the liquid polysulfide oligomer with bisphenol-A diacrylate resin. Real-time Fourier transform infrared spectroscopy (FTIR analysis showed that the molecular weight of the liquid polysulfide oligomer had no effect on mercaptan functional group conversion. The obtained elastomers continued to keep low temperature flexibility of polysulfide except Elastomer-LP3, which was due to higher content of bisphenol-A structure. All the samples had a tensile strength of over 0.7 MPa, which was comparable to that of polysulfide polymer cured by metal oxide. Moreover, the samples exhibited higher thermal stability than metal oxide cured polysulfide. This vulcanization methodology will provide a fast, efficient, and environmentally friendly approach (without metal oxides and plasticizers for preparing polysulfide elastomers.

  6. Stereochemistry of 16a-Hydroxyfriedelin and 3-Oxo-16-methylfriedel-16-ene Established by 2D NMR Spectroscopy

    Directory of Open Access Journals (Sweden)

    Vagner Fernandes Knupp

    2009-02-01

    Full Text Available Friedelin (1, 3b-friedelinol (2, 28-hydroxyfriedelin (3, 16a-hydroxyfriedelin (4, 30-hydroxyfriedelin (5 and 16a,28-dihydroxyfriedelin (6 were isolated through fractionation of the hexane extract obtained from branches of Salacia elliptica. After a week in CDCl3 solution, 16a-hydroxyfriedelin (4 reacted turning into 3-oxo-16-methylfriedel-16-ene (7. This is the first report of a dehydration followed by a Nametkin rearrangement of a pentacyclic triterpene in CDCl3 solution occurring in the NMR tube. These seven pentacyclic triterpenes was identified through NMR spectroscopy and the stereochemistry of compound 4 and 7 was established by 2D NMR (NOESY spectroscopy and mass spectrometry (GC-MS. It is also the first time that all the 13C-NMR and 2D NMR spectral data are reported for compounds 4 and 7.

  7. Facile preparation of organic-silica hybrid monolith for capillary hydrophilic liquid chromatography based on "thiol-ene" click chemistry.

    Science.gov (United States)

    Chen, Ming-Luan; Zhang, Jun; Zhang, Zheng; Yuan, Bi-Feng; Yu, Qiong-Wei; Feng, Yu-Qi

    2013-04-05

    In this work, a one-step approach to facile preparation of organic-inorganic hybrid monoliths was successfully developed. After vinyl-end organic monomers and azobisisobutyronitrile (AIBN) were mixed with hydrolyzed tetramethoxysilane (TMOS) and 3-mercaptopropyltrimethoxysilane (MPTMS), the homogeneous mixture was introduced into a fused-silica capillary for simultaneous polycondensation and "thiol-ene" click reaction to form the organic-silica hybrid monoliths. By employing this strategy, two types of organic-silica hybrid monoliths with positively charged quaternary ammonium and amide groups were prepared, respectively. The functional groups were successfully introduced onto the monoliths during the sol-gel process with "thiol-ene" click reaction, which was demonstrated by ζ-potential assessment, energy dispersive X-ray spectroscopy (EDX), and Fourier transform infrared (FT-IR) spectroscopy. The porous structure of the prepared monolithic columns was examined by scanning electron microscopy (SEM), nitrogen adsorption-desorption measurement, and mercury intrusion porosimetry. These results indicate the prepared organic-silica hybrid monoliths possess homogeneous column bed, large specific surface area, good mechanical stability, and excellent permeability. The prepared monolithic columns were then applied for anion-exchange/hydrophilic interaction liquid chromatography. Different types of analytes, including benzoic acids, inorganic ions, nucleosides, and nucleotides, were well separated with high column efficiency around 80,000-130,000 plates/m. Taken together, we present a facile and universal strategy to prepare organic-silica hybrid monoliths with a variety of organic monomers using one-step approach. Copyright © 2013 Elsevier B.V. All rights reserved.

  8. Thiol-ene synthesis and characterization of lithium bis(malonato)borate single-ion conducting gel polymer electrolytes.

    Science.gov (United States)

    Weber, Ryan L; Mahanthappa, Mahesh K

    2017-10-25

    The development of high capacity anodes and high voltage cathodes for advanced lithium-ion batteries motivates the search for new polymer electrolytes that exhibit superior electrochemical stabilities and high ionic conductivities. We report a convenient, three-step synthesis of lithium bis(non-8-enyl-malonato)borate (LiBNMB) as a α,ω-diene monomer, which undergoes thermally initiated thiol-ene crosslinking polymerizations in propylene carbonate to yield gel polymer electrolytes with high lithium ion concentrations (∼0.9 M). By conducting these crosslinking polymerizations using mixtures of di- and tri-thiols and LiBNMB with [thiol] : [ene] = 1 : 1, we synthesized a series of gel networks with dynamic elastic moduli ranging from G' = 40-79 kPa that increase monotonically with trifunctional crosslinker content. While ionic conductivities for these polymer gels measured by electrochemical impedance spectroscopy at 22 °C are σ = 0.82-2.5 × 10 -6 S cm -1 , we show that the conductivity of propylene carbonate-solvated lithium ions though the bulk of these gel electrolytes is 8.5 × 10 -5 S cm -1 independent of crosslinker density. However, the conductivities of the gel interfaces depend sensitively on crosslinker content, suggesting the importance of segmental rearrangement dynamics at the electrode interface in limiting the rate of ion motion. Thus, the design of highly conductive polymer electrolytes for advanced batteries demands careful design of both the internal and interfacial properties of these new materials.

  9. Surface modification of model hydrogel contact lenses with hyaluronic acid via thiol-ene "click" chemistry for enhancing surface characteristics.

    Science.gov (United States)

    Korogiannaki, Myrto; Zhang, Jianfeng; Sheardown, Heather

    2017-10-01

    Discontinuation of contact lens wear as a result of ocular dryness and discomfort is extremely common; as many as 26% of contact lens wearers discontinue use within the first year. While patients are generally satisfied with conventional hydrogel lenses, improving on-eye comfort continues to remain a goal. Surface modification with a biomimetic, ocular friendly hydrophilic layer of a wetting agent is hypothesized to improve the interfacial interactions of the contact lens with the ocular surface. In this work, the synthesis and characterization of poly(2-hydroxyethyl methacrylate) surfaces grafted with a hydrophilic layer of hyaluronic acid are described. The immobilization reaction involved the covalent attachment of thiolated hyaluronic acid (20 kDa) on acrylated poly(2-hydroxyethyl methacrylate) via nucleophile-initiated Michael addition thiol-ene "click" chemistry. The surface chemistry of the modified surfaces was analyzed by Fourier transform infrared spectroscopy-attenuated total reflectance and X-ray photoelectron spectroscopy. The appearance of N (1s) and S (2p) peaks on the low resolution X-ray photoelectron spectroscopy spectra confirmed successful immobilization of hyaluronic acid. Grafting hyaluronic acid to the poly(2-hydroxyethyl methacrylate) surfaces decreased the contact angle, the dehydration rate, and the amount of nonspecific sorption of lysozyme and albumin in comparison to pristine hydrogel materials, suggesting the development of more wettable surfaces with improved water-retentive and antifouling properties, while maintaining optical transparency (>92%). In vitro testing also showed excellent viability of human corneal epithelial cells with the hyaluronic acid-grafted poly(2-hydroxyethyl methacrylate) surfaces. Hence, surface modification with hyaluronic acid via thiol-ene "click" chemistry could be useful in improving contact lens surface properties, potentially alleviating symptoms of contact lens related dryness and discomfort during

  10. The IS-ENES climate4impact portal: bridging the CMIP5 and CORDEX data to impact users

    Science.gov (United States)

    Som de Cerff, Wim; Plieger, Maarten; Page, Christian; Tatarinova, Natalia; Hutjes, Ronald; de Jong, Fokke; Bärring, Lars; Sjökvist, Elin; Vega Saldarriaga, Manuel; Santiago Cofiño Gonzalez, Antonio

    2015-04-01

    The aim of climate4impact (climate4impact.eu) is to enhance the use of Climate Research Data and to enhance the interaction with climate effect/impact communities. The portal is based on 17 impact use cases from 5 different European countries, and is evaluated by a user panel consisting of use case owners. It has been developed within the IS-ENES European project and is currently operated and further developed in the IS ENES2 project. As the climate impact community is very broad, the focus is mainly on the scientific impact community. Climate4impact is connected to the Earth System Grid Federation (ESGF) nodes containing global climate model data (GCM data) from the fifth phase of the Coupled Model Intercomparison Project (CMIP5) and regional climate model data (RCM) data from the Coordinated Regional Climate Downscaling Experiment (CORDEX). This global network of climate model data centers offers services for data description, discovery and download. The climate4impact portal connects to these services using OpenID, and offers a user interface for searching, visualizing and downloading global climate model data and more. A challenging task is to describe the available model data and how it can be used. The portal informs users about possible caveats when using climate model data. All impact use cases are described in the documentation section, using highlighted keywords pointing to detailed information in the glossary. Climate4impact currently has two main objectives. The first one is to work on a web interface which automatically generates a graphical user interface on WPS endpoints. The WPS calculates climate indices and subset data using OpenClimateGIS/icclim on data stored in ESGF data nodes. Data is then transmitted from ESGF nodes over secured OpenDAP and becomes available in a new, per user, secured OpenDAP server. The results can then be visualized again using ADAGUC WMS. Dedicated wizards for processing of climate indices will be developed in close

  11. Thiol-ene thermosets exploiting surface reactivity for layer-by-layer structures and control of penetration depth for selective surface reactivity

    DEFF Research Database (Denmark)

    Daugaard, Anders Egede; Westh, Andreas; Pereira Rosinha Grundtvig, Ines

    Thiol-ene thermosets have been shown to be an efficient platform for preparation of functional polymer surfaces. Especially the effectiveness and versatility of the system has enabled a large variety of network properties to be obtained in a simple and straight-forward way. Due to its selectivity...... groups in thµe surface of thiol-ene thermosets, it is possible to prepare surface functional thermosets or to exploit the reactive groups for modular construction and subsequent chemical bonding. Here a different approach preparing monolithic layer-by-layer structures with controlled mechanical...... in controlling the penetration depth and surface grafting. The methodology was used for surface immobilization of enzymes providing a direct link between the distribution of enzymes on the surface and the activity of the reactor....

  12. ?Grafting to? of RAFTed Responsive Polymers to Glass Substrates by Thiol?Ene and Critical Comparison to Thiol?Gold Coupling

    OpenAIRE

    Biggs, Caroline I.; Walker, Marc; Gibson, Matthew I.

    2016-01-01

    Surface-grafted polymers have been widely applied to modulate biological interfaces and introduce additional functionality. Polymers derived from reversible addition?fragmentation transfer (RAFT) polymerization have a masked thiol at the ?-chain end providing an anchor point for conjugation and in particular displays high affinity for gold surfaces (both flat and particulate). In this work, we report the direct grafting of RAFTed polymers by a ?thiol?ene click? (Michael addition) onto glass s...

  13. Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles.

    Science.gov (United States)

    Yan, Yue; Fu, Jie; Wang, Tianfu; Lu, Xiuyang

    2017-03-15

    As efficient drug carriers, stimuli-responsive mesoporous silica nanoparticles are at the forefront of research on drug delivery systems. An acid-responsive system based on silyl ether has been applied to deliver a hybrid prodrug. Thiol-ene click chemistry has been successfully utilized for tethering this prodrug to mesoporous silica nanoparticles. Here, by altering the steric bulk of the substituent on the silicon atom, the release rate of a model drug, camptothecin, was controlled. The synthesized drug delivery system was investigated by analytical methods to confirm the functionalization and conjugation of the mesoporous silica nanoparticles. Herein, trimethyl silyl ether and triethyl silyl ether were selected to regulate the release rate. Under normal plasma conditions (pH 7.4), both types of camptothecin-loaded mesoporous silica nanoparticles (i.e., MSN-Me-CPT and MSN-Et-CPT) did not release the model drug. However, under in vitro acidic conditions (pH 4.0), based on a comparison of the release rates, camptothecin was released from MSN-Me-CPT more rapidly than from MSN-Et-CPT. To determine the biocompatibility of the modified mesoporous silica nanoparticles and the in vivo camptothecin uptake behavior, MTT assays with cancer cells and confocal microscopy observations were conducted, with positive results. These functionalized nanoparticles could be useful in clinical treatments requiring controlled drug release. As the release rate of drug from drug-carrier plays important role in therapy effects, trimethyl silyl ether (TMS) and triethyl silyl ether (TES) were selected as acid-sensitive silanes to control the release rates of model drugs conjugated from MSNs by thiol-ene click chemistry. The kinetic profiles of TMS and TES materials have been studied. At pH 4.0, the release of camptothecin from MSN-Et-CPT occurred after 2h, whereas MSN-Me-CPT showed immediate drug release. The results showed that silyl ether could be used to control release rates of drugs from

  14. Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription.

    Science.gov (United States)

    Osorio, Alex A; Muñóz, Alejandro; Torres-Romero, David; Bedoya, Luis M; Perestelo, Nayra R; Jiménez, Ignacio A; Alcamí, José; Bazzocchi, Isabel L

    2012-06-01

    In the present study we report the isolation of nine new olean-18-ene triterpenes (1-9), along with three known ones (10-12), from Cassine xylocarpa and Maytenus jelskii. Their stereostructures have been elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR techniques (COSY, ROESY, HSQC and HMBC), and spectrometric methods. The natural compounds and derivatives 13-15 have been tested for their potential as inhibitors of human immunodeficiency virus type 1 replication. Five compounds from this series displayed potent antiviral activity with IC(50)s in the micromolar range (1, 3, 4, 7 and 8) being 1 and 8 the most active compounds. The target of these compounds was different from antiretroviral drugs currently licensed as they act as inhibitors of enhancer-dependent transcription. The structure-activity relationships were established based on the regiosubstitution and oxidation degree of the triterpene scaffold, revealing that these aspects were able to modulate the selectivity and intensity of HIV inhibition. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  15. Thiol-Ene Photo-Click Collagen-PEG Hydrogels: Impact of Water-Soluble Photoinitiators on Cell Viability, Gelation Kinetics and Rheological Properties

    Directory of Open Access Journals (Sweden)

    Róisín Holmes

    2017-06-01

    Full Text Available Thiol-ene photo-click hydrogels were prepared via step-growth polymerisation using thiol-functionalised type-I collagen and 8-arm poly(ethylene glycol norbornene-terminated (PEG-NB, as a potential injectable regenerative device. Type-I collagen was thiol-functionalised by a ring opening reaction with 2-iminothiolane (2IT, whereby up to 80 Abs.% functionalisation and 90 RPN% triple helical preservation were recorded via 2,4,6-Trinitrobenzenesulfonic acid (TNBS colorimetric assay and circular dichroism (CD. Type, i.e., either 2-Hydroxy-1-[4-(2-hydroxyethoxy phenyl]-2-methyl-1-propanone (I2959 or lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP, and concentration of photoinitiator were varied to ensure minimal photoinitiator-induced cytotoxicity and to enable thiol-ene network formation of collagen-PEG mixtures. The viability of G292 cells following 24 h culture in photoinitiator-supplemented media was largely affected by the photoinitiator concentration, with I2959-supplemented media observed to induce higher toxic response (0.1 → 0.5% (w/v I2959, cell survival: 62 → 2 Abs.% compared to LAP-supplemented media (cell survival: 86 → 8 Abs.%. In line with the in vitro study, selected photoinitiator concentrations were used to prepare thiol-ene photo-click hydrogels. Gelation kinetics proved to be largely affected by the specific photoinitiator, with LAP-containing thiol-ene mixtures leading to significantly reduced complete gelation time (τ: 187 s with respect to I2959-containing mixtures (τ: 1683 s. Other than the specific photoinitiator, the photoinitiator concentration was key to adjusting the hydrogel storage modulus (G’, whereby 15-fold G’ increase (232 → 3360 Pa was observed in samples prepared with 0.5% (w/v compared to 0.1% (w/v LAP. Further thiol-ene formulations with 0.5% (w/v LAP and varied content of PEG-NB were tested to prepare photo-click hydrogels with porous architecture, as well as tunable storage modulus (G

  16. Isolation and characterization of a thermotolerant ene reductase from Geobacillus sp. 30 and its heterologous expression in Rhodococcus opacus.

    Science.gov (United States)

    Tsuji, Naoto; Honda, Kohsuke; Wada, Mayumi; Okano, Kenji; Ohtake, Hisao

    2014-07-01

    Rhodococcus opacus B-4 cells are adhesive to and even dispersible in water-immiscible hydrocarbons owing to their highly lipophilic nature. In this study, we focused on the high operational stability of thermophilic enzymes and applied them to a biocatalytic conversion in an organic reaction medium using R. opacus B-4 as a lipophilic capsule of enzymes to deliver them into the organic medium. A novel thermo- and organic-solvent-tolerant ene reductase, which can catalyze the enantioselective reduction of ketoisophorone to (6R)-levodione, was isolated from Geobacillus sp. 30, and the gene encoding the enzyme was heterologously expressed in R. opacus B-4. Another thermophilic enzyme which catalyzes NAD(+)-dependent dehydrogenation of cyclohexanol was identified from the gene-expression library of Thermus thermophilus and the gene was coexpressed in R. opacus B-4 for cofactor regeneration. While the recombinant cells were not viable in the mixture due to high reaction temperature, 634 mM of (6R)-levodione could be produced with an enantiopurity of 89.2 % ee by directly mixing the wet cells of the recombinant R. opacus with a mixture of ketoisophorone and cyclohexanol at 50 °C. The conversion rate observed with the heat-killed recombinant cells was considerably higher than that obtained with a cell-free enzyme solution, demonstrating that the accessibility between the substrates and enzymes could be improved by employing R. opacus cells as a lipophilic enzyme capsule. These results imply that a combination of thermophilic enzymes and lipophilic cells can be a promising approach for the biocatalytic production of water-insoluble chemicals.

  17. Biotransformation of ent-kaur-16-ene and ent-trachylobane 7β-acetoxy derivatives by the fungus Gibberella fujikuroi (Fusarium fujikuroi).

    Science.gov (United States)

    Fraga, Braulio M; Bressa, Carlo; González-Vallejo, Victoria; González, Pedro; Guillermo, Ricardo

    2012-09-01

    Candol A (7β-hydroxy-ent-kaur-16-ene) (6) is efficiently transformed by Gibberella fujikuroi into the gibberellin plant hormones. In this work, the biotransformation of its acetate by this fungus has led to the formation of 7β-acetoxy-ent-kaur-16-en-19-oic acid (3), whose corresponding alcohol is a short-lived intermediate in the biosynthesis of gibberellins and seco-ring ent-kaurenoids in this fungus. Further biotransformation of this compound led to the hydroxylation of the 3β-positions to give 7β-acetoxy-3β-hydroxy-ent-kaur-16-en-19-oic acid (14), followed by a 2β- or 18-hydroxylation of this metabolite. The incubation of epicandicandiol 7β-monoacetate (7β-acetoxy-18-hydroxy-ent-kaur-16-ene) (10) produces also the 19-hydroxylation to form the 18,19 diol (20), which is oxidized to give the corresponding C-18 or C-19 acids. These results indicated that the presence of a 7β-acetoxy group does not inhibit the fungal oxidation of C-19 in 7β-acetoxy-ent-kaur-16-ene, but avoids the ring B contraction that leads to the gibberellins and the 6β-hydroxylation necessary for the formation of seco-ring B ent-kaurenoids. The biotransformation of 7β-acetoxy-ent-trachylobane (trachinol acetate) (27) only led to the formation of 7β-acetoxy-18-hydroxy-ent-trachylobane (33). Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. Glavni oltar Uznesenja Marijina iz župne crkve Uznesenja Blažene Djevice u Vrbniku: valorizacija primjene Poly(2-etil-2-oksazolina) kao zamjene za tutkalo

    OpenAIRE

    Krstulović, Nevena

    2015-01-01

    Konzervatorsko-restauratorski radovi na glavnom oltaru Uznesenja Marijina iz župne crkve Uznesenja Blažene Djevice Marije u Vrbniku započeti su 2012. godine u Restauratorskom odjelu Rijeka Hrvatskog restauratorskog zavoda (HRZ). Istraživački radovi pokazali su da je središnji dio oltara izvorno potpuno pozlaćen polimentnom pozlatom, dok su bočna krila pozlaćena samo djelomično. Zbog lošeg stanja i osjetljivosti pozlate odlučeno je provesti podljepljivanje i stabiliziranje slikanog sloja upotr...

  19. C-H Acetoxylation-Based Chemical Synthesis of 17 β-Hydroxymethyl-17 α-methyl-18-norandrost-13-ene Steroids.

    Science.gov (United States)

    Hurski, Alaksiej L; Barysevich, Maryia V; Dalidovich, Tatsiana S; Iskryk, Marharyta V; Kolasava, Nastassia U; Zhabinskii, Vladimir N; Khripach, Vladimir A

    2016-09-26

    Palladium-catalyzed C-H acetoxylation has been proposed as a key transformation in the first chemical synthesis of steroids bearing a unique 17β-hydroxymethyl-17α-methyl-18-nor-13-ene D-fragment. This C-H functionalization step was crucial for inverting the configuration at the quaternary stereocenter of a readily available synthetic intermediate. The developed approach was applied to prepare the metandienone metabolite needed as a reference substance in anti-doping analysis to control the abuse of this androgenic anabolic steroid. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Ära söö kiles saia ehk kas poliitilist kunsti on võimalik mõista? = Do not eat white bread in plastic, or is it possible to understand political art? / Ene-Liis Semper, Eero Epner

    Index Scriptorium Estoniae

    Semper, Ene-Liis, 1969-

    2006-01-01

    Poliitillisest teatrist. NO99 lavastusest "Nafta" (lavastajad, autorid: Tiit Ojasoo, Ene-Liis Semper, kunstnik Ene-Liis Semper). Ettekanne Kaasaegse Kunsti Eesti Keskuse 4. ettekannete päeval "Kunstnike moraalsed valikud kultuurikonfliktides" Tallinna Kunstihoones 27.04.2006. Bibliograafia lk. 112

  1. Porušena crkva Rođenja Blažene Djevice Marije u Silbi

    Directory of Open Access Journals (Sweden)

    Eugen Motušić

    2014-12-01

    Full Text Available Već otprije je bio poznat podatak da se godine 1828. u Silbi porušila stara crkva Rođenja B.D. Marije kako bi se dobivenim građevinskim materijalom dovršila prekinuta gradnja nove župne crkve koja naslijeđuje i njen titular. Prema arhivskim podacima rušenje je dozvolio zadarski nadbiskup Josip Nowak i odredio da se do izgradnje nove crkve kao župna koristi nekadašnja franjevačka Gospe od Karmela. Od čitavog je sklopa do danas sačuvan tek zvonik koji je ostao služiti novoj župnoj crkvi. Prema shematiziranim tlocrtu i dimenzijama porušene crkve, dokumentiranima u danas zagubljenom spisu iz župnog arhiva, razvidno je da se radilo o jednobrodnoj longitudinalnoj crkvi s pravokutnom, od lađe užom sakristijom na začelju, dvjema plitkim kapelama dograđenima uz pobočne zidove, te otvorenim predvorjem (ložom duž pročelja koje se svojim južnim uglom oslanjalo na ugao zvonika. Crkvena je dvorana osim glavnog oltara prislonjenog uz začelje lađe imala tri para pobočnih oltara. Analiza apostolskih i kanonskih vizitacija crkve, prvi puta spomenute 1579. godine, pokazuje da je još u drugoj četvrtini 17. stoljeća ona bila skromna građevina u kojoj se, radi udaljenosti tadašnje župne crkve sv. Marka od naselja, čuva ulje za bolesničko pomazanje. Ipak, crkva je tada imala pet pobočnih oltara koje podižu ugledniji pojedinci i laičke bratovštine od kojih se isticala ona Gospe od Ružarija po kojoj se i crkva tijekom 18. stoljeća pučki nazivala. Na temelju analize zapisa vizitacije nadbiskupa Evanđeliste Parzaghija iz 1670. godine, zaključuje se da je crkva netom prije njegova pohoda pregrađena, dok se prilikom opisa pojedinih oltara navodi da su u ovoj obnovi mijenjali poziciju. Godine 1678. prvi se put spominje zvonik – kampanel. Komparativnom analizom može se ustvrditi da je crkva Male Gospe u Silbi svojom tipologijom pripadala brojnoj skupini jednostavnih, prostranih, ali prema građevnim oblicima ruralnih crkava

  2. Synthesis of Upconverting Hydrogel Nanocomposites Using Thiol-Ene Click Chemistry: Template for the Formation of Dendrimer-Like Gold Nanoparticle Assemblies.

    Science.gov (United States)

    Meesaragandla, Brahmaiah; Mahalingam, Venkataramanan

    2015-11-16

    The synthesis of upconverting hydrogel nanocomposites by base-catalyzed thiol-ene click reaction between 10-undecenoic acid capped Yb(3+)/Er(3+)-doped NaYF4 nanoparticles and pentaerythritol tetrakis(3-mercaptopropionate) (PETMP) as tetrathiol monomer is reported. This synthetic strategy for nanocomposite gels is quite different from works where usually the preformed gels are mixed with the nanoparticles. Developing nanocomposites by surface modification of capping ligands would allow tuning and controlling of the separation of the nanoparticles inside the gel network. The hydrogel nanocomposites prepared by thiol-ene click reaction show strong enhancement in luminescence intensity compared to 10-undecenoic acid-capped Yb(3+)/Er(3+)-doped NaYF4 nanoparticles through the upconversion process (under 980 nm laser excitation). The hydrogel nanocomposites display strong swelling characteristics in water resulting in porous structures. Interestingly, the resulting nanocomposite gels act as templates for the synthesis of dendrimer-like Au nanostructures when HAuCl4 is reduced in the presence of the nanocomposite gels. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. A combination of "thiol-ene" click chemistry and surface initiated atom transfer radical polymerization: Fabrication of boronic acid functionalized magnetic graphene oxide composite for enrichment of glycoproteins.

    Science.gov (United States)

    Su, Jie; He, Xiwen; Chen, Langxing; Zhang, Yukui

    2018-04-01

    An efficient glycoproteins enrichment platform is one of vital preprocessing steps in biomarker research and in particular glycoproteomics. In this work, a well-defined boronic acid functionalized magnetic graphene oxide nanocomposite (Fe 3 O 4 -GO@PAAPBA) was synthesized for the selective enrichment of glycoproteins from complex biological samples via a novel strategy based on the "thiol-ene" click chemistry and surface initiated atom transfer radical polymerization (SI-ATRP). The initiator of ATRP was anchored to the surface of substrate through "thiol-ene" click reaction. The product Fe 3 O 4 -GO@PAAPBA was successfully synthesized in following SI-ATRP. The Fe 3 O 4 -GO@PAAPBA nanocomposite was characterized by transmission electron microscopy (TEM), Fourier transform-infrared spectroscopy (FTIR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometry (VSM) and thermogravimetric analysis. The adsorption capacity of Fe 3 O 4 -GO@PAAPBA towards ovalbumin (OVA) and transferrin (Trf) is 471mgg -1 and 450mgg -1 , respectively. The nanocomposite also featured good selectivity to glycoproteins in the mixture of glycoproteins and non-glycoproteins at alkaline (pH 9.0) and physiological conditions (pH 7.4). Furthermore, it can be applied to extract glycoproteins directly from egg white samples. These results have indicated that Fe 3 O 4 -GO@PAAPBA was a potential affinity material in glycoprotein analysis. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Pyriculins A and B, two monosubstituted hex-4-ene-2,3-diols and other phytotoxic metabolites produced by Pyricularia grisea isolated from buffelgrass (Cenchrus ciliaris).

    Science.gov (United States)

    Masi, Marco; Meyer, Susan; Górecki, Marcin; Mandoli, Alessandro; Di Bari, Lorenzo; Pescitelli, Gennaro; Cimmino, Alessio; Cristofaro, Massimo; Clement, Suzette; Evidente, Antonio

    2017-11-01

    Pyricularia grisea has been identified as a foliar pathogen on buffelgrass (Cenchrus ciliaris) in North America and was studied as a potential source of phytotoxins for buffelgrass control. Two monosubstituted hex-4-ene-2,3-diols, named pyriculins A and B, were isolated from its culture filtrate organic extract together with (10S,11S)-(-)-epipyriculol, trans-3,4-dihydro-3,4,8-trihydroxy-1(2H)-napthalenone, and (4S)-(+)-isosclerone. Pyriculins A and B were characterized by spectroscopic (essentially nuclear magnetic resonance [NMR], High-resolution electrospray ionization mass spectrometry [HRESIMS]) and chemical methods such as (4E)-1-(4-hydroxy-1,3-dihydroisobenzofuran-1-yl)hex-4-ene-2,3-diols. The relative and absolute configuration of these compounds was determined by a combination of spectroscopic (NMR, electronic circular dichroism [ECD]) and computational tools. When bioassayed in a buffelgrass coleoptile and radicle elongation test, (10S,11S)-(-)-epipyriculol proved to be the most toxic compound. Seed germination was much reduced and slowed with respect to the control and radicles failed to elongate. All five compounds delayed germination, but only (10S,11S)-(-)-epipyriculol was able to prevent radicle development of buffelgrass seedlings. It had no effect on coleoptile elongation, while the other four compounds caused significantly increased coleoptile development relative to the control. © 2017 Wiley Periodicals, Inc.

  5. Whats 'App-ening'

    DEFF Research Database (Denmark)

    Ankersen, Dorit V; Weimers, Petra; Burisch, Johan

    2017-01-01

    with healthcare professionals. A more holistic approach that educates patients and enables them to communicate directly with eCare provider through a web application is one of the functions most requested by patients. SUMMARY: eHealth solutions for digestive diseases have a supportive function and a positive...... impact on patients. However, there is a need to increase patient education and further develop the possibility for care team-patient communication within eHealth solutions....

  6. Grunge kodukujunduses / Ene Vool

    Index Scriptorium Estoniae

    Vool, Ene, 1948-

    2004-01-01

    Low-tech, campi ja grunge ehitus- ja sisustusstiilidest meil ja mujal - kommenteerivad Andro Kööp ja Ain Nurmela. Tutvustatakse ka Mari-Mira projekti Pariisis, mis kujutab endast nn. mutant-küla, putka- ja onnikultuuri koketeriid. Artikli lõpus kommenteerib kunstiteadlane Karin Paulus grungestiili muusikas, riietuses ja sisekujunduses.

  7. Limitations of the Neurological Evolutional Exam (ENE as a motor assessment for first graders Limitações do Exame Neurológico Evolutivo (ENE como um instrumento de avaliação motora para crianças da primeira série

    Directory of Open Access Journals (Sweden)

    Priscila M. Caçola

    2010-10-01

    Full Text Available BACKGROUND: Many clinicians and researchers in Brazil consider the Neurological Developmental Exam (NDE, a valid and reliable assessment for Brazilian school-aged children. However, since its inception, several tests have emerged that, according to some researchers, provide more in-depth evaluation of motor ability and go beyond the detection of general motor status (soft neurological signs. OBJECTIVES: To highlight the limitations of the NDE as a motor skill assessment for first graders. METHODS: Thirty-five children were compared on seven selected items of the NDE, seven of the Bruininks-Oseretsky Test (BOT, and seven of the Visual-Motor Integration test (VMI. Participants received a "pass" or "fail" score for each item, as prescribed by the respective test manual. RESULTS: Chi-square and ANOVA results indicated that the vast majority of children (74% passed the NDE items, whereas values for the other tests were 29% (BOT and 20% (VMI. Analysis of specific categories (e.g. visual, fine, and gross motor coordination revealed a similar outcome. CONCLUSIONS: Our data suggest that while the NDE may be a valid and reliable test for the detection of general motor status, its use as a diagnostic/remedial tool for identifying motor ability is questionable. One of our recommendations is the consideration of a revised NDE in light of the current needs of clinicians and researchers.CONTEXTUALIZAÇÃO: Muitos clínicos e pesquisadores brasileiros consideram o Exame Neurológico Evolutivo (ENE, um instrumento válido e confiável para crianças brasileiras em idade escolar. Entretanto, desde a sua criação, surgiram outros testes para uma avaliação mais profunda de habilidade motora, os quais vão além de detectar status motor geral em forma de sinais neurológicos leves. OBJETIVOS: Demonstrar os pontos fracos do ENE como teste de avaliação de habilidade motora para crianças de primeira série. MÉTODOS: Trinta e cinco crianças realizaram 7 itens

  8. Microwave-Assisted Kinetic Resolution of Homochiral (Z-Cyclooct-5-ene-1,2-diol and (Z-2-Acetoxycyclooct-4-enyl Acetate Using Lipases

    Directory of Open Access Journals (Sweden)

    Hervé Rouillard

    2014-07-01

    Full Text Available Over the last decade, the use of biocatalysts has become an attractive alternative to conventional chemical methods, especially for organic synthesis, due to their unusual properties. Among these enzymes, lipases are the most widely used, because they are cheap, easily available, cofactor-free, and have broad substrate specificity. Combined to microwave heating in non-aqueous medium, recent results suggest that irradiation may influence the enzyme activity. This Communication reports the benefits of lipases and the microwave irradiation on the kinetic resolution of racemic homochiral (Z-cyclooct-5-ene-1,2-diol and (Z-2-acetoxycyclooct-4-enyl acetate. In order to best achieve the kinetic resolution, different parameters were studied including the type of lipase, the temperature, the impact of microwave power compared to conventional heating. Optimization of the reaction parameters lead to the obtainment of highly enriched or enantiopure diols and diesters in a clean, efficient and safe way.

  9. C(10)-C(19) bond cleavage reaction of 19-oxygenated androst-4-ene-3,6-dione steroids under various conditions.

    Science.gov (United States)

    Nagaoka, Masao; Numazawa, Mitsuteru

    2004-08-01

    C(10)-C(19) bond cleavage reaction of 19-hydroxy- and 19-oxoandrost-4-ene-3,6,17-triones (5, 6) was explored under various conditions. Treatment of steroids 5 and 6 with KOH in MeOH gave the A-ring aromatized product 6-oxoestrone (11) in a fair yield, respectively, in contrast, the treatment with a weak base yielded 4-methyl steroid 17 (20%) in the case of 19-alcohol 5 or 19-nor-Delta(5(10))-steroid 9 (12-67%) along with compound 11 (6-27%) in the case of 19-aldehyde 6. Reaction of compound 6 with HCl in MeOH produced 3-methyl ethers of 6-oxoestrone and Delta(6)-estrone, compounds 12 and 14 (ca. 20% each). Thus, 6-oxosteroids 5 and 6 showed unique C(10)-C(19) bond cleavage reactions with a base or acid.

  10. The photochemical thiol-ene reaction as a versatile method for the synthesis of glutathioneS-conjugates targeting the bacterial potassium efflux system Kef.

    Science.gov (United States)

    Healy, Jess; Rasmussen, Tim; Miller, Samantha; Booth, Ian R; Conway, Stuart J

    2016-04-29

    The thiol-ene coupling reaction is emerging as an important conjugation reaction that is suitable for use in a biological setting. Here, we explore the utility of this reaction for the synthesis of glutathione- S -conjugates (GSX) and present a general, operationally simple, protocol with a wide substrate scope. The GSX afforded are an important class of compounds and provide invaluable molecular tools to study glutathione-binding proteins. In this study we apply the diverse library of GSX synthesised to further our understanding of the structural requirements for binding to the glutathione-binding protein, Kef, a bacterial K + efflux system, found in many bacterial pathogens. This system is vital to the survival of bacteria upon exposure to electrophiles, and plays an essential role in the maintenance of intracellular pH and K + homeostasis. Consequently, Kef is an appealing target for the development of novel antibacterial drugs.

  11. Liquid chromatography–tandem mass spectrometry method for simultaneous determination of valproic acid and its ene-metabolites in epilepsy patient plasma

    Directory of Open Access Journals (Sweden)

    Huan Lu

    2016-04-01

    Full Text Available A simple and high throughput method was developed and validated for simultaneous determination of valproic acid and its two toxicant ene-metabolites, 2-enevalproic acid and 4-enevalproic acid in epilepsy patient plasma using liquid chromatography–tandem mass spectrometry. Probenecid was used as internal standard and solid-phase extraction was selected for sample preparation. A chromatographic separation was performed on an Agilent Poroshell SB-C18 column (50 mm×4.6 mm i.d., 2.7 μm by an optimized gradient elution at a flow rate of 0.9 mL/min. The total run time was 7 min. Electrospray ionization was used in negative ion mode by multiple reaction monitoring of the precursor-to-product ion transitions at m/z 143.0→143.0 for valproic acid, m/z 140.9→140.9 for 2-enevalproic acid and 4-enevalproic acid for their poor fragments, and m/z 283.9→239.9 for probenecid. The results showed good linearity of valproic acid, 2-enevalproic acid and 4-enevalproic acid in their respective linear ranges. The correlation coefficients were more than 0.998. The intra- and inter-day precision of the assay was less than 11.0% and the accuracy ranged from 2% to 12%. This analytical method was successfully applied to assay plasma concentrations of valproic acid and its two ene-metabolites in epilepsy patient plasma and used for therapeutic drug monitoring.

  12. Organic reactions of sulfur dioxide. IV. A facile regiospecific hydrogen-deuterium exchange in olefins. Consequence of the intermediacy of allylic sulfinic acids in the ene reaction of sulfur dioxide with double bonds

    International Nuclear Information System (INIS)

    Masilamani, D.; Rogic, M.M.

    1978-01-01

    It is reported that the isomerization of the double bond, and presumably the rearrangement of the allylic sulfinic acid intermediates is completely suppressed in the presence of water. The reaction of sulfur dioxide with the double bond and the ene reaction in the resulting dipolar ions are apparently not affected. As a consequence, in the presence of deuterium oxide a very facile exchange of the allylic hydrogens and deuterium takes place

  13. Enantioselective synthesis of possible diastereomers of heptadeca-1-ene-4,6-diyne-3,8,9,10-tetrol; putative structure of a conjugated diyne natural product isolated from Hydrocotyle leucocephala.

    Science.gov (United States)

    Prasad, Kavirayani R; Swain, Bandita

    2011-04-01

    Enantioselective synthesis of possible diastereomers of heptadeca-1-ene-4,6-diyne-3,8,9,10-tetrol, a structure proposed for the natural product isolated from Hydrocotyle leucocephala is accomplished. The reported spectral data of the natural product did not match those of any of the isomers that were synthesized and established that the structure proposed for the natural product is not correct and requires revision.

  14. Crystal and Molecular Structure Studies of Ethyl 4-(4-Hydroxyphenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate and Ethyl 4-(3-Bromophenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate

    Directory of Open Access Journals (Sweden)

    Badiadka Narayana

    2012-08-01

    Full Text Available The crystal and molecular structures of the title compounds, ethyl 4-(4-hydroxyphenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate (I and ethyl 4-(3-bromophenyl-6-(6-methoxy-2-naphthyl-2-oxocyclohex-3-ene-1-carboxylate (II, are reported and confirmed by single crystal X-ray diffraction data. Compound (I, C26H24O5, crystallizes from a methanol solution in the monoclinic C2/c space group with eight molecules in the unit cell. The unit cell parameters are: a = 25.4114(5 Å, b = 8.47440(10 Å, c = 20.6921(4 Å, β = 108.328(2° and V = 4229.92(13 Å3. Disorder is observed throughout the entire molecule with an occupancy ratio 0.690(2:0.310(2. Compound (II, C26H23O4Br, crystallizes from an ethyl acetate solution in the monoclinic P21/c spacegroup with four molecules in the unit cell. The unit cell parameters are a = 17.8991(9 Å, b = 11.4369(6 Å, c = 10.8507(5 Å, β = 92.428(4° and V = 2219.25(19 Å3. Disorder is observed in the cyclohexenone ring and the carboxylate group with an occupancy ratio 0.830(6:0.170(6. Weak O–H...O (I or C–H...O (II intermolecular interactions are observed which influence crystal packing stability. These chalcone derivative types of molecules are important in their ability to act as activated unsaturated systems in conjugated addition reactions of carbanions in the presence of basic catalysts which exhibit a multitude of biological activities.

  15. Poly(allyl methacrylate) functionalized hydroxyapatite nanocrystals via the combination of surface-initiated RAFT polymerization and thiol-ene protocol: a potential anticancer drug nanocarrier.

    Science.gov (United States)

    Bach, Long Giang; Islam, Md Rafiqul; Vo, Thanh-Sang; Kim, Se-Kwon; Lim, Kwon Taek

    2013-03-15

    Hydroxyapatite nanocrystals (HAP NCs) were encapsulated by poly(allyl methacrylate) (PolyAMA) employing controlled surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization of allyl methacrylate to afford HAP-PolyAMA nanohybrids. The subsequent thiol-ene coupling of nanohybrids with 2-mercaptosuccinic acid resulted HAP-Poly(AMA-COOH) possessing multicarboxyl group. The formation of the nanohybrids was confirmed by FT-IR and EDS analyses. The TGA and FE-SEM investigation were further suggested the grafting of PolyAMA onto HAP NCs. The utility of the HAP-PolyAMA nanohybrid as drug carrier was also explored. The pendant carboxyl groups on the external layers of nanohybrids were conjugated with anticancer drug cisplatin to afford HAP-Poly(AMA-COOH)/Pt complex. The formation of the complex was confirmed by FT-IR, XPS, and FE-SEM. In vitro evaluation of the synthesized complex as nanomedicine revealed its potential chemotherapeutic efficacy against cancer cell lines. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. The synthesis of weak acidic type hybrid monolith via thiol-ene click chemistry and its application in hydrophilic interaction chromatography.

    Science.gov (United States)

    Zeng, Jiao; Liu, Shengquan; Wang, Menglin; Yao, Shouzhuo; Chen, Yingzhuang

    2017-05-01

    In this work, a porous structure and good permeability monolithic column was polymerized in UV transparent fused-silica capillaries via photo-initiated thiol-ene click polymerization of 2,4,6,8-tetravinyl-2,4,6,8-tetramethylcyclotetrasiloxane (TMTVS), pentaerythritol tetra(3-mercaptopropionate)(PETMP), itaconic acid, respectively, in the presence of porogenic solvents (tetrahydrofuranand methanol) and an initiator (2,2-dimethoxy-2-phenylacetophenone) (DMPA) within 30 min. The physical properties of this monolith were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and nitrogen adsorption/desorption measurements. For an overall evaluation of the monolith in chromatographic application, separations of polycyclic aromatic hydrocarbons (PAHs), phenols, amides and bases were carried out. The column efficiency of this monolith could be as high as 112 560 N/m. It also possesses a potential application in fabrication of monoliths with high efficiency for c-LC. In addition, the resulting monolithic column demonstrated the potential use in analysis of environment waters. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Synthesis of Pyridine and Spiropyridine Derivatives Derived from 2-aminoprop- 1-ene-1,1,3-tricarbonitrile Together with their c-Met Kinase and Antiproliferative Evaluations.

    Science.gov (United States)

    Mohareb, Rafat M; Abouzied, Amr S; Abbas, Nermeen S

    2018-02-07

    Among a wide range of pyridines, 3-cyanopyridines acquired a special attention due to their wide range of pharmacological activities especially the therapeutic activities. Many pharmacological drugs containing the pyridine nucleus were known in the market. The aim of this work was to synthesize target molecules not only possess anti-tumor activities but also kinase inhibitors. To achieve this goal, our strategy was to synthesize a series of 3-cyanopyridine derivatives using 2-aminoprop-1-ene-1,1,3-tricarbonitrile (1) as the key starting material for many heterocyclization reactions. Muticoponent reactions were adopted using compound 1 to get different pyridine derivatives that were capable for different heterocyclization reactions. Antiproliferative evaluations and c-Met kinase, Pim-1 kinse inhibitions were perform where some compounds gave high activities. Compounds that showed high antiprolifeative activity were tested gor c-Met-independent and the results showed that compounds 5c, 5e, 5f, 7c, 7f and 16d were more active than foretinib. The Pim-1 kinase inhibition activity of some selected compounds showed that compounds 5e and 16c were high potent to inhibit Pim-1 activity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  18. “Grafting to” of RAFTed Responsive Polymers to Glass Substrates by Thiol–Ene and Critical Comparison to Thiol–Gold Coupling

    Science.gov (United States)

    2016-01-01

    Surface-grafted polymers have been widely applied to modulate biological interfaces and introduce additional functionality. Polymers derived from reversible addition–fragmentation transfer (RAFT) polymerization have a masked thiol at the ω-chain end providing an anchor point for conjugation and in particular displays high affinity for gold surfaces (both flat and particulate). In this work, we report the direct grafting of RAFTed polymers by a “thiol–ene click” (Michael addition) onto glass substrates rather than gold, which provides a more versatile surface for subsequent array-based applications but retains the simplicity. The immobilization of two thermoresponsive polymers are studied here, poly[oligo(ethylene glycol) methyl ether methacrylate] (pOEGMA) and poly(N-isopropylacrylamide) (pNIPAM). Using a range of surface analysis techniques the grafting efficiency was compared to thiol–gold and was quantitatively compared to the gold alternative using quartz crystal microbalance. It is shown that this method gives easy access to grafted polymer surfaces with pNIPAM resulting in significantly increased surface coverage compared to pOEGMA. The nonfouling (protein resistance) character of these surfaces is also demonstrated. PMID:27409356

  19. "Grafting to" of RAFTed Responsive Polymers to Glass Substrates by Thiol-Ene and Critical Comparison to Thiol-Gold Coupling.

    Science.gov (United States)

    Biggs, Caroline I; Walker, Marc; Gibson, Matthew I

    2016-08-08

    Surface-grafted polymers have been widely applied to modulate biological interfaces and introduce additional functionality. Polymers derived from reversible addition-fragmentation transfer (RAFT) polymerization have a masked thiol at the ω-chain end providing an anchor point for conjugation and in particular displays high affinity for gold surfaces (both flat and particulate). In this work, we report the direct grafting of RAFTed polymers by a "thiol-ene click" (Michael addition) onto glass substrates rather than gold, which provides a more versatile surface for subsequent array-based applications but retains the simplicity. The immobilization of two thermoresponsive polymers are studied here, poly[oligo(ethylene glycol) methyl ether methacrylate] (pOEGMA) and poly(N-isopropylacrylamide) (pNIPAM). Using a range of surface analysis techniques the grafting efficiency was compared to thiol-gold and was quantitatively compared to the gold alternative using quartz crystal microbalance. It is shown that this method gives easy access to grafted polymer surfaces with pNIPAM resulting in significantly increased surface coverage compared to pOEGMA. The nonfouling (protein resistance) character of these surfaces is also demonstrated.

  20. 16α-Hydroxyfriedelin and 3-Oxo-16-methylfriedel-16-ene as Building Blocks: Crystal Structure and Hirshfeld Surfaces Decoding Intermolecular Contacts

    Directory of Open Access Journals (Sweden)

    Rodrigo S. Corrêa

    2013-01-01

    Full Text Available In this paper the importance of C–H⋯O intermolecular hydrogen bonds and van der Waals forces in crystal packing stabilization of 16α-hydroxyfriedelin (1 and 3-oxo-16-methylfriedel-16-ene (2 is described. Compound 1 is a natural product isolated from the hexane extract of Salacia elliptica branches, whereas compound 2 is obtained from compound 1 after dehydration accompanied by methyl migration of C-17 to C-16. The single-crystal X-ray diffraction experiments for 1 and 2 were carried out at 150 K, and the crystallographic study demonstrated that these compounds crystallize in noncentrosymmetric space groups, with 1 showing an orthorhombic P212121 space group and 2 a monoclinic P21 one. Compounds 1 and 2 are composed of five fused six-membered rings presenting a chair conformation, except for the central ring of 2, which adopts a half-chair conformation. In addition, the intra- and intermolecular parameters were studied using CCDC MOGUL analyses and Hirshfeld surfaces.

  1. Synthesis of 3 beta,16 beta,19-trihydroxyandrost-5-en-17-one and 16 beta,19-dihydroxyandrost-4-ene-3,17-dione and their 19-oxo derivatives.

    Science.gov (United States)

    Numazawa, M; Mutsumi, A; Hoshi, K; Ishimura, S; Shoji, S; Sekihara, H

    1990-09-01

    3 beta,16 beta,19-Trihydroxyandrost-5-en-17-one (12) was synthesized from 5 alpha-bromo-3 beta-acetoxy-6 beta,19-epoxyandrostan-17-one (2) through acetoxylation at C-16 beta of the enol acetate 4 with lead tetraacetate and reductive cleavage of the epoxide ring with zinc dust yielding the 3 beta,16 beta-diacetoxy-19-hydroxy steroid 11, followed by hydrolysis of the acetoxy groups with sulfuric acid. Jones oxidation of compound 11 followed by the acid hydrolysis gave the 19-oxo steroid 15. 5 alpha-Bromo-3 beta-hydroxy-16 beta-acetoxy-6 beta,19-epoxyandrostan-17-one (8), obtained by selective hydrolysis of the 3-formate 5 with ammonium hydroxide, was oxidized with Jones reagent to afford the 3-oxo steroid 16, which was converted into the 19-hydroxy derivative 17 by treatment with zinc dust. 16 beta,19-Dihydroxyandrost-4-ene-3,17-dione (18) and its 19-oxo derivative 21 were obtained from compound 17 through a similar reaction sequence.

  2. Thiol-ene immobilisation of carbohydrates onto glass slides as a simple alternative to gold-thiol monolayers, amines or lipid binding.

    Science.gov (United States)

    Biggs, Caroline I; Edmondson, Steve; Gibson, Matthew I

    2015-01-01

    Carbohydrate arrays are a vital tool in studying infection, probing the mechanisms of bacterial, viral and toxin adhesion and the development of new treatments, by mimicking the structure of the glycocalyx. Current methods rely on the formation of monolayers of carbohydrates that have been chemically modified with a linker to enable interaction with a functionalised surface. This includes amines, biotin, lipids or thiols. Thiol-addition to gold to form self-assembled monolayers is perhaps the simplest method for immobilisation as thiolated glycans are readily accessible from reducing carbohydrates in a single step, but are limited to gold surfaces. Here we have developed a quick and versatile methodology which enables the use of thiolated carbohydrates to be immobilised as monolayers directly onto acrylate-functional glass slides via a 'thiol-ene'/Michael-type reaction. By combining the ease of thiol chemistry with glass slides, which are compatible with microarray scanners this offers a cost effective, but also useful method to assemble arrays.

  3. Preparation and characterization of hydrophilic hybrid monoliths via thiol-ene click polymerization and their applications in chromatographic analysis and glycopeptides enrichment.

    Science.gov (United States)

    Bai, Jingyao; Liu, Zhongshan; Wang, Hongwei; You, Xin; Ou, Junjie; Shen, Yehua; Ye, Mingliang

    2017-05-19

    A macroporous hydrophilic organic-silica hybrid monolithic column was synthesized via photoinitiated thiol-ene click polymerization reaction of 1-thioglycerol-modified polyhedral oligomeric vinylsilsesquioxane (vinylPOSS) and dithiothreitol (DTT) in a binary porogenic system consisting of tetrahydrofuran (THF) and dodecanol. 1-Thioglycerol was used to modify vinylPOSS in order to form a precursor with good solubility in the binary porogenic system. The influences of both the ratio of 1-thioglycerol/vinylPOSS and the porogenic solvents on the morphology and permeability of hybrid monoliths were studied in detail. The physical properties of hybrid monolith were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and nitrogen adsorption/desorption measurement. The chromatographic performance was evaluated by separation of neutral polar compounds in capillary liquid chromatography (cLC). The resulting column possessed homogeneous macroporous structure and showed hydrophilic interaction liquid chromatography (HILIC) separation mechanism with high efficiency of 65,000Nm -1 for formamide. Ultimately, the hybrid matrix was grafted with hydrazine groups and then exhibited the ability of glycopeptides enrichment. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Thiol-ene Michael-type formation of gelatin/poly(ethylene glycol) biomatrices for three-dimensional mesenchymal stromal/stem cell administration to cutaneous wounds

    Science.gov (United States)

    Xu, Kedi; Cantu, David Antonio; Fu, Yao; Kim, Jaehyup; Zheng, Xiaoxiang; Hematti, Peiman; Kao, W. John

    2013-01-01

    Mesenchymal stromal/stem cells (MSCs) are considered promising cellular therapeutics in the fields of tissue engineering and regenerative medicine. MSCs secrete high concentrations of immunomodulatory cytokines and growth factors, which exert paracrine effects on infiltrating immune and resident cells of the wound microenvironment that could favorably promote healing after acute injury. However, better spatial delivery and improved retention at the site of injury are two factors that could improve the clinical application of MSCs. In this study, we utilized thiol-ene Michael-type addition for rapid encapsulation of MSCs within a gelatin/poly(ethylene glycol) biomatrix; this biomatrix was also applied as a provisional dressing to full-thickness wounds in Sprague-Dawley rats. The three-way interaction of MSCs, gelatin/poly(ethylene glycol) biomatrices, and host immune cells and adjacent resident cells of the wound microenvironment favorably modulated wound progression and host response. In this model we observed attenuated immune cell infiltration, lack of foreign giant cell (FBGC) formation, accelerated wound closure and re-epithelialization, as well as enhanced neovascularization and granulation tissue formation by 7 days. The MSC-entrapped gelatin/poly(ethylene glycol) biomatrix localized the presentation of MSCs adjacent to the wound microenvironment and thus, mediated early resolution of inflammatory events and facilitated proliferative phases in wound healing. PMID:23811217

  5. C60 and Sc3N@C80(TMB-PPO derivatives as constituents of singlet oxygen generating, thiol-ene polymer nanocomposites

    Directory of Open Access Journals (Sweden)

    Ashli R. Toles

    2016-07-01

    Full Text Available Numerous functionalization methods have been employed to increase the solubility, and therefore, the processability of fullerenes in composite structures, and of these radical addition reactions continue to be an important methodology. C60 and Sc3N@C80 derivatives were prepared via radical addition of the photodecomposition products from the commercial photoinitiator TMB-PPO, yielding C60(TMB-PPO5 and Sc3N@C80(TMB-PPO3 as preferred soluble derivatives obtained in high yields. Characterization of the mixture of isomers using standard techniques suggests an overall 1PPO:6TMB ratio of addends, reflecting the increased reactivity of the carbon radical. Although, a higher percentage of PPO is observed in the Sc3N@C80(TMB-PPO3 population, perhaps due to reverse electronic requirements of the substrate. Visually dispersed thiol-ene nanocomposites with low extractables were prepared using two monomer compositions (PETMP:TTT and TMPMP:TMPDE with increasing fullerene derivative loading to probe network structure-property relationships. Thermal stability of the derivatives and the resulting networks decreased with increased functionality and at high fullerene loadings, respectively. TMPMP:TMPDE composite networks show well-dispersed derivatives via TEM imaging, and increasing Tg’s with fullerene loading, as expected for the incorporation of a more rigid network component. PETMP:TTT composites show phase separation in TEM, which is supported by the observed Tg’s. Singlet oxygen generation of the derivatives decreases with increased functionality; however, this is compensated for by the tremendous increase in solubility in organic solvents and miscibility with monomers. Most importantly, singlet oxygen generation from the composites increased with fullerene derivative loading, with good photostability of the networks.

  6. Design of thiol-ene photoclick hydrogels using facile techniques for cell culture applications†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4bm00187gClick here for additional data file.

    Science.gov (United States)

    Sawicki, Lisa A; Kloxin, April M

    2014-11-30

    Thiol-ene 'click' chemistries have been widely used in biomaterials applications, including drug delivery, tissue engineering, and controlled cell culture, owing to their rapid, cytocompatible, and often orthogonal reactivity. In particular, hydrogel-based biomaterials formed by photoinitiated thiol-ene reactions afford spatiotemporal control over the biochemical and biomechanical properties of the network for creating synthetic materials that mimic the extracellular matrix or enable controlled drug release. However, the use of charged peptides functionalized with cysteines, which can form disulfides prior to reaction, and vinyl monomers that require multistep syntheses and contain ester bonds, may lead to undesired inhomogeneity or degradation under cell culture conditions. Here, we designed a thiol-ene hydrogel formed by the reaction of allyloxycarbonyl-functionalized peptides and thiol-functionalized poly(ethylene glycol). Hydrogels were polymerized by free radical initiation under cytocompatible doses of long wavelength ultraviolet light in the presence of water-soluble photoinitiators (lithium acylphosphinate, LAP, and 2-hydroxy-1-[4-(2-hydroxyethoxy)phenyl]-2-methyl-1-propanone, Irgacure 2959). Mechanical properties of these hydrogels were controlled by varying the monomer concentration to mimic a range of soft tissue environments, and hydrogel stability in cell culture medium was observed over weeks. Patterns of biochemical cues were created within the hydrogels post-formation and confirmed through the incorporation of fluorescently-labeled peptides and Ellman's assay to detect free thiols. Human mesenchymal stem cells remained viable after encapsulation and subsequent photopatterning, demonstrating the utility of the monomers and hydrogels for three-dimensional cell culture. This facile approach enables the formation and characterization of hydrogels with well-defined, spatially-specific properties and expands the suite of monomers available for three

  7. Studies directed towards a mechanistic evaluation of inactivation of aromatase by the suicide substrates androsta-1,4-diene-3,17-diones and its 6-ene derivatives aromatase inactivation by the 19-substituted derivatives and their enzymic aromatization.

    Science.gov (United States)

    Numazawa, Mitsuteru; Nagaoka, Masao; Handa, Wakako; Ogawa, Yoko; Matsuoka, Satomi

    2007-01-01

    To gain insight into the mechanistic features for aromatase inactivation by the typical suicide substrates, androsta-1,4-diene-3,17-dione (ADD, 1) and its 6-ene derivative 2, we synthesized 19-substituted (methyl and halogeno) ADD and 1,4,6-triene derivatives 8 and 10 along with 4,6-diene derivatives 9 and tested for their ability to inhibit aromatase in human placental microsomes as well as their ability to serve as a substrate for the enzyme. 19-Methyl-substituted steroids were the most powerful competitive inhibitors of aromatase (K(i): 8.2-40 nM) in each series. Among the 19-substituted inhibitors examined, 19-chloro-ADD and its 6-ene derivatives (7b and 9b) inactivated aromatase in a time-dependent manner in the presence of NADPH in air while the other ones did not. The time-dependent inactivation was blocked by the substrate AD and required NADPH. Only the time-dependent inactivators 7b and 9b in series of 1,4-diene and 1,4,6-triene steroids as well as all of 4,6-diene steroids 9, except for the methyl compound 9a, served as a substrate for aromatase to yield estradiol and/or its 6-ene estradiol with lower conversion rates compared to the corresponding parent steroids 1,4-diene, 1,4,6-triene and 4,6-diene derivatives. The present findings strongly suggest that the aromatase reaction, 19-oxygenation, at least in part, would be involved in the time-dependent inactivation of aromatase by the suicide substrates 1 and 2, where the 19-substitutent would play a critical role in the aromatase reaction probably though steric and electronic reasons.

  8. Synphos modified Pt nanoclusters, their heterogenization by silica sol-gel entrapment, and catalytic activity in hydrogenolysis of bicyclo[2.2.2]oct-7-enes and hydrogenation of ethyl pyruvate

    Energy Technology Data Exchange (ETDEWEB)

    Neatu, F; Parvulescu, V I [Faculty of Chemistry, Department of Chemical Technology and Catalysis, University of Bucharest, B-dul Regina Elisabeta 4-12, Bucharest 030018 (Romania); Kraynov, A [Jacobs University Bremen, Campus Ring 8, D-28759 Bremen (Germany); Kranjc, K; Kocevar, M [Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, SI-1000 Ljubljana (Slovenia); Ratovelomanana-Vidal, V [Laboratoire de Synthese Selective Organique et Produits Naturels, Ecole Nationale Superieure de Chimie de Paris, UMR 7573 CNRS, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05 (France); Richards, R [Department of Chemistry and Geochemistry, Colorado School of Mines, 1500 Illiniois, Golden, CO 80401 (United States)], E-mail: v_parvulescu@chem.unibuc.ro, E-mail: virginie-vidal@enscp.fr, E-mail: rrichard@mines.edu

    2008-06-04

    Platinum (Pt) colloids modified by the chiral ligand synphos were prepared with the goal of obtaining a catalytic nanomaterial and were subsequently embedded in silica to form a heterogeneous catalyst. The systems were characterized by {sup 31}P-NMR, x-ray diffraction, molecular modeling and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTs) measurements. These colloids, both as 'quasi-homogeneous catalysts' (or soluble heterogeneous catalysts) and embedded in silica (heterogeneous catalysts) were employed in the selective hydrogenolysis of highly sterically constrained bicyclo[2.2.2]oct-7-enes and hydrogenation of ethyl pyruvate.

  9. Aproximación a la situación de salud en tres comunidades Asháninkas ubicadas en las cuencas del río Tambo y Ene, 2006

    OpenAIRE

    Carolina Tarqui-Mamani; Javier Vargas-Herrera; Elisa Terreros-Martínez; Walter Torres

    2009-01-01

    En mayo de 2006 se realizó un estudio transversal en tres comunidades Asháninkas ubicadas en las cuencas de los ríos Tambo y Ene, para describir su situación de salud. Se definió la situación salud sobre la base de cinco indicadores: prevalencia de la desnutrición infantil, enfermedades diarreicas agudas (EDA), infecciones respiratorias agudas (IRA), mortalidad materna y mortalidad infantil. Se interrogó a los padres o madres de familia acerca de defunciones en menores de 1 año, defunciones m...

  10. LEADER-tegevusest / Ene Sarapuu

    Index Scriptorium Estoniae

    Sarapuu, Ene

    2009-01-01

    Läänemaa LEADER-tegevusgrupi eesmärk on maakonna kui terviku ühtne areng, et kogu Läänemaa oleks vajalike teenustega kaetud ning ettevõtjad julgeks ning suudaks uute teenuste ja toodetega turule tulla

  11. Comeniuse reis Sitsiiliasse / Ene Toomsalu

    Index Scriptorium Estoniae

    Toomsalu, Ene

    2011-01-01

    Viljandimaa Kalmetu põhikool osalemisest Comeniuse projektis, kus kahe aasta jooksul tutvutakse Kreeka, Hollandi, Hispaania, Tšehhi ja Poola koolide ning õppetegevusega, seekord saadi kokku Sitsiilias

  12. Parim personaliprojekt 2014 / Ene Olle

    Index Scriptorium Estoniae

    Olle, Ene

    2014-01-01

    Personalijuhtimise ühingu PARE konverentsil "Töötajat väärtustav organisatsioon" pälvis tiitli "Parim personaliprojekt 2013" ettevõtte ISS Eesti erivajadustega inimeste värbamise projekt. Teistest konkursil osalenud projektidest

  13. Toivo Raidmetsa show / Ene Ammer

    Index Scriptorium Estoniae

    Ammer, Ene

    1999-01-01

    Toivo Raidmetsast, tema mööbli-, näituse- ja ruumikujundustest, esinemistest näitustel, tööst Eesti Kunstiakadeemia sisearhitektuuri kateedri juhatajana, koostööst Eero Jürgensoni, Jaak Arro ja Taso Mähariga. 12 illustratsiooni

  14. Messiuudised : Maison & Objet / Ene Jakobi

    Index Scriptorium Estoniae

    Jakobi, Ene

    2008-01-01

    Uusi trende kõige suuremalt disainimessilt Maison & Objet Prantsusmaal - Jean-Charles de Castelbajaci joonistatud toolid, Jean-Christophe Bernardi pleksiklaasist tool ja laud, Joseph Licciardi ja Paul Coheni-Philipp Veenendaali etanoolil põlevad kaminad, Philippe Lebru kellad, Vincenzo Antonuccio vaasid ja Anna Siedlecka ning Radek Achramoviczi täispuhutavad valgustid

  15. Paleoenvironmental significance of aluminum phosphate-sulfate minerals in the upper Cretaceous ooidal ironstones, E-NE Aswan area, southern Egypt

    Science.gov (United States)

    Salama, Walid

    2014-09-01

    Aluminum phosphate-sulfate (APS) minerals are present as small, disseminated crystals in the upper Cretaceous shallow marine ooidal ironstones, E-NE Aswan area, southern Egypt. Their association with the ironstones is considered as a proxy of subaerial weathering and post-diagenetic meteoric water alteration. The mineralogical composition of the ooidal ironstones was investigated by optical and scanning electron microscopes, X-ray diffraction, Fourier transform infrared and Raman spectroscopy. The ooidal ironstones are composed mainly of ooids and groundmass, both of which consist of a mixture of detrital (quartz) and diagenetic (fluorapatite, chamosite and pyrite) mineral assemblages. These mineral assemblages are destabilized under acidic and oxidizing, continental conditions. These conditions resulted from the oxidation of pyrite and probably organic matter under warm and humid, tropical climate followed the Santonian Sea regression and subaerial exposure. These pedogenic conditions promoted corrosion of quartz, dissolution of chamosite and apatite and hydrolysis of feldspars of the nearby exposed granitoids. The released Si, Al and Sr from quartz, chamosite and feldspars; Fe and S from pyrite and P, Ca and light rare earth elements (LREE) from apatite are reprecipitated as hematite, kaolinite, apatite and APS minerals from the pore fluids or along fractures. The paragenetic sequence and textural relationships of this post-diagenetic mineral assemblage indicate that hematite was formed by replacement of chamosite followed by formation of a secondary generation of pore filling chlorapatite and APS minerals and finally the precipitation of kaolinite in the remaining pore spaces. The formation of APS minerals and chlorapatite is simultaneous, but APS minerals are stable at shallow depths under acidic to neutral pH conditions, whereas chlorapatite is stable under alkaline pH conditions. Alkaline conditions were maintained at greater depths when the infiltrated

  16. Synthesis and Evaluation of in Vitro Biological Activity of 4-Substituted Arylpiperazine Derivatives of 1,7,8,9-Tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

    Directory of Open Access Journals (Sweden)

    David Collu

    2009-12-01

    Full Text Available A series of twenty arylpiperazine derivatives of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione have been prepared. These derivatives were tested in vitro with the aim of identifying novel lead compounds active against emergent and re-emergent human and cattle infectious diseases (AIDS, hepatitis B and C, tuberculosis, bovine viral diarrhea. In particular, these compounds were evaluated in vitro against representatives of different virus classes, such as a HIV-1 (Retrovirus, a HBV (Hepadnavirus and the single-stranded RNA+ viruses Yellow fever virus (YFV and Bovine viral diarrhea virus (BVDV, both belonging to the Flaviridae. Compounds 2c, 2g and 3d showed a modest activity against CVB-2. The molecular structures of the starting imide 1 and one of propyl-piperazine derivatives, 3b, have been determined by an X-ray crystallography study.

  17. Efficient DNA-Polymer Coupling in Organic Solvents: A Survey of Amide Coupling, Thiol-Ene and Tetrazine-Norbornene Chemistries Applied to Conjugation of Poly(N-Isopropylacrylamide).

    Science.gov (United States)

    Wilks, Thomas R; O'Reilly, Rachel K

    2016-12-16

    A range of chemistries were explored for the efficient covalent conjugation of DNA to poly(N-isopropylacrylamide) (poly(NIPAM)) in organic solvents. Amide coupling and thiol-ene Michael addition were found to be ineffective for the synthesis of the desired products. However, the inverse electron-demand Diels-Alder (DA inv ) reaction between tetrazine (Tz) and norbornene (Nb) was found to give DNA-polymer conjugates in good yields (up to 40%) in organic solvents (N,N-dimethylformamide, N,N-dimethylacetamide and N-methyl-2-pyrrolidone), and without the need for a catalyst. Methods for the synthesis of Tz-and Nb- functionalised DNA were developed, along with a post-polymerisation functionalisation strategy for the production of Tz-functionalised polymers.

  18. Çene Kemiklerinin Metastatik Tümörleri (***) 7 Olgu Bildirisi ve Öteki Kemiklerin Metastatik Tümörleriyle Karşılaştırma

    OpenAIRE

    ÇÖLOĞLU, A.; TAHSİNOĞLU, Melih; GÜRSU, Kamil

    2013-01-01

    ÖZETBu çalışmada 147 kemik metastazı olgusu incelendi. Bu olgulardan 7 sinin altçenede yerleştiği saptandı. Bu olguların mikroskopik tanıları şöyleydi; mesane karsinomu, böbrek hücreli karsinom, meme karsinomu, hipernefrom, pleomorfik adenokarsinom ve kökeni saptanamayan 2 karsinom. Bu olgulardan böbrek hücreli karsinom ve primeri saptanamayan 1 karsinom olgusunda ilk belirtiler çene metastazlarıydı. Konuyla ilgili literatür verileri, bizim bulgularımızla karşılaştırıldı.SUMMARYOne hundred fo...

  19. Selection of DNA barcoding loci and phylogenetic study of a medicinal and endemic plant, Plectranthus asirensis J.R.I. Wood from Saudi Arabia.

    Science.gov (United States)

    Al-Qurainy, F; Khan, S; Nadeem, M; Tarroum, M; Al-Ameri, A

    2014-08-07

    Genuine medicinal plant materials are very important for potential crude drug production, which can be used to cure many human diseases. DNA barcoding of medicinal plants is an effective way to identify adulterated or contaminated market materials, but it can be quite challenging to generate barcodes and analyze the data to determine discrimination power. The molecular phylogeny of a plant species infers its relationship to other species. We screened the various loci of the nuclear and chloroplast genome for the barcoding of Plectranthus asirensis, an endemic plant of Saudi Arabia. The chloroplast genome loci such as rps16 and rpoB showed maximum similarity to taxa of the same and other genera via BLAST of the National Center for Biotechnology Information (NCBI) GenBank database; hence, they are less preferable for the development of a DNA barcode. However, nrDNA-ITS and chloroplast loci rbcL and rpoC1 showed less similarity via BLAST of the NCBI GenBank database; therefore, they could be used for DNA barcoding for this species.

  20. Síntese e atividade fitotóxica de 2-fenil-6,7-exo-isopropilidenodioxi-8-oxabiciclo [3.2.1]oct-2-eno Synthesis and phytotoxic activity of 2-Phenyl-6,7-exo isopropylidenedioxi-8-oxabicyclo[3.2.1]oct-2-ene

    Directory of Open Access Journals (Sweden)

    Luiz Cláudio A. Barbosa

    2000-08-01

    Full Text Available The [3+4] cycloaddition between furan and the oxyallyl cation generated from 1-bromo-1-phenylpropan-2-one (4, resulted in the formation of 2-phenyl-8-oxabicyclo[3.2.1]oct-6-en-3-one (5 in 30% yield. This compound was further converted into 2-phenyl-6,7-exo-isopropylidenedioxi-8-oxabicyclo[3.2.1]oct-2-ene (13 in 35.4% yield. The selective effect of compound (13 and its isomer 3-phenyl-6,7-exo-isopropylidenedioxi-8-oxabicyclo[3.2.1]oct -2-ene (1a on the radicle growth of Sorghum bicolor L. (sorghum and Cucumis sativus L. (cucumber were evaluated. For both plants, compound 13 showed to be more potent than its isomer 1a.

  1. Rhodium-catalyzed [5 + 2 + 1] cycloaddition of ene-vinylcyclopropanes and CO: reaction design, development, application in natural product synthesis, and inspiration for developing new reactions for synthesis of eight-membered carbocycles.

    Science.gov (United States)

    Wang, Yi; Yu, Zhi-Xiang

    2015-08-18

    Practical syntheses of natural products and their analogues with eight-membered carbocyclic skeletons are important for medicinal and biological investigations. However, methods and strategies to construct the eight-membered carbocycles are limited. Therefore, developing new methods to synthesize the eight-membered carbocycles is highly desired. In this Account, we describe our development of three rhodium-catalyzed cycloadditions for the construction of the eight-membered carbocycles, which have great potential in addressing the challenges in the synthesis of medium-sized ring systems. The first reaction described in this Account is our computationally designed rhodium-catalyzed two-component [5 + 2 + 1] cycloaddition of ene-vinylcyclopropanes (ene-VCPs) and CO for the diastereoselective construction of bi- and tricyclic cyclooctenones. The design of this reaction is based on the hypothesis that the C(sp(3))-C(sp(3)) reductive elimination of the eight-membered rhodacycle intermediate generated from the rhodium-catalyzed cyclopropane cleavage and alkene insertion, giving Wender's [5 + 2] cycloadduct, is not easy. Under CO atmosphere, CO insertion may occur rapidly, converting the eight-membered rhodacycle into a nine-membered rhodacycle, which then undergoes an easy C(sp(2))-C(sp(3)) reductive elimination process and furnishes the [5 + 2 + 1] product. This hypothesis was supported by our preliminary DFT studies and also served as inspiration for the development of two [7 + 1] cycloadditions: the [7 + 1] cycloaddition of buta-1,3-dienylcyclopropanes (BDCPs) and CO for the construction of cyclooctadienones, and the benzo/[7 + 1] cycloaddition of cyclopropyl-benzocyclobutenes (CP-BCBs) and CO to synthesize the benzocyclooctenones. The efficiency of these rhodium-catalyzed cycloadditions can be revealed by the application in natural product synthesis. Two eight-membered ring-containing natural products, (±)-asterisca-3(15),6-diene and (+)-asteriscanolide, have been

  2. 17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson's Disease.

    Science.gov (United States)

    Nicoletti, Ferdinando; Philippens, Ingrid; Fagone, Paolo; Ahlem, Clarence N; Reading, Christopher L; Frincke, James M; Auci, Dominick L

    2012-01-01

    17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) is a synthetic androstenetriol in Phase II clinical development for the treatment of inflammatory diseases. HE3286 was evaluated for blood-brain barrier (BBB) permeability in mice, and efficacy in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) murine model of Parkinson's disease (PD). We found that HE3286 freely penetrated the BBB. HE3286 treatment significantly improved motor function compared to vehicle in the rotarod test (mean 58.2 sec versus 90.9 sec, P < 0.0001), and reduced inflammatory mediator gene expression in the brain (inducible nitric oxide synthase, 20%, P = 0.002; tumor necrosis factor α, 40%, P = 0.038, and interleukin-1β, 33%, P = 0.02) measured by reverse-transcriptase polymerase chain reaction. Brain tissue histopathology and immunohistochemistry showed that HE3286 treatment increased the numbers of tyrosine hydroxylase-positive cells by 17% compared to vehicle (P = 0.003), and decreased the numbers of damaged neurons by 38% relative to vehicle (P = 0.029). L-3,4-dihydroxyphenylalanine (L-DOPA) efficacy was not enhanced by concurrent administration of HE3286. HE3286 administration prior to MPTP did not enhance efficacy. Our data suggest a potential role for HE3286 in PD treatment, and provides incentive for further investigation.

  3. 17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286 Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease

    Directory of Open Access Journals (Sweden)

    Ferdinando Nicoletti

    2012-01-01

    Full Text Available 17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286 is a synthetic androstenetriol in Phase II clinical development for the treatment of inflammatory diseases. HE3286 was evaluated for blood-brain barrier (BBB permeability in mice, and efficacy in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP murine model of Parkinson’s disease (PD. We found that HE3286 freely penetrated the BBB. HE3286 treatment significantly improved motor function compared to vehicle in the rotarod test (mean 58.2 sec versus 90.9 sec, P<0.0001, and reduced inflammatory mediator gene expression in the brain (inducible nitric oxide synthase, 20%, P=0.002; tumor necrosis factor α, 40%, P=0.038, and interleukin-1β, 33%, P=0.02 measured by reverse-transcriptase polymerase chain reaction. Brain tissue histopathology and immunohistochemistry showed that HE3286 treatment increased the numbers of tyrosine hydroxylase-positive cells by 17% compared to vehicle (P=0.003, and decreased the numbers of damaged neurons by 38% relative to vehicle (P=0.029. L-3,4-dihydroxyphenylalanine (L-DOPA efficacy was not enhanced by concurrent administration of HE3286. HE3286 administration prior to MPTP did not enhance efficacy. Our data suggest a potential role for HE3286 in PD treatment, and provides incentive for further investigation.

  4. Molecular structure, vibrational spectroscopic, first order hyperpolarizability and HOMO-LUMO studies of 7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.

    Science.gov (United States)

    Ramalingam, M; Sethuraman, V; Sundaraganesan, N

    2011-02-01

    The FT-IR and FT-Raman spectra of 7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (7AVCA) were recorded in the region 4000-400 cm(-1) and 3500-10 cm(-1), respectively. Quantum chemical calculations of energies, geometrical structure and vibrational wavenumbers were carried out by ab initio HF and density functional theoretical methods invoking 6-311G(d,p) basis set. The differences between the observed and scaled wavenumber values of most of the fundamentals are very small. The electric dipole moment (μ) and the first order hyperpolarizability (β0) values have been computed quantum mechanically. The calculated results show that 7AVCA may have microscopic nonlinear optical (NLO) behavior with non-zero values. A detailed interpretation of the FT-IR and FT-Raman spectra of 7AVCA is reported. The theoretical IR and Raman spectra of 7AVCA have also been constructed. The calculated HOMO and LUMO energies show that the charge transfer occurs within the molecule. Copyright © 2010 Elsevier B.V. All rights reserved.

  5. The traditional medicine Spilanthes acmella, and the alkylamides spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, demonstrate in vitro and in vivo anti-malarial activity

    Science.gov (United States)

    Spelman, Kevin; Depoix, Delphine; McCray, Megan; Mouray, Elisabeth; Grellier, Philippe

    2010-01-01

    Spilanthes spp. are used as traditional herbal medicines in Africa and India to treat malaria. Yet, to date, there is no data on active constituents or most effective extraction methods for this indication. The isolated alkylamides, spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, found in S. acmella Murr., were shown to have IC50s of 16.5 μg/mL and 41.4 μg/mL on Plasmodium falciparum strain PFB and IC50s of 5.8 μg/mL and 16.3 μg/mL for the chloroquine resistant P. falciparum K1 strain, respectively. Further investigations revealed that at relatively low concentrations, spilanthol and the water extract of S. acmella reduced the parasitemia 59% and 53% in mice infected with P. yoelii yoelii 17XNL at 5 mg/kg and 50 mg/kg, respectively. Unexpectedly, the 95% ethanol extract of S. acmella was less effective (36% reduction in parasitemia) at 50 mg/kg. These results provide the first evidence supporting S. acmella against malaria and demonstrating active constituents in S. acmella against P. falciparum. PMID:22692989

  6. Zinc(II PVC-based membrane sensor based on 5,6-benzo-4,7,13,16,21,24- hexaoxa-1,10-diazabicyclo[8,8,8]hexacos-5-ene

    Directory of Open Access Journals (Sweden)

    Zamani Hassan Ali

    2006-01-01

    Full Text Available The 5,6-benzo-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8,8,8]hexacos-5-ene (BHDE was used as an excellent ionophore in construction of a Zn(II PVC-based membrane sensor. The best performance was obtained with a membrane composition of 30% poly(vinyl chloride, 64.5% nitrobenzen (NB, 2.5% BHDE and 3% sodium tetraphenylborate (NaTPB. This sensor shows very good selectivity and sensitivity towards zinc ion over a wide variety of cations, including alkali, alkaline earth, transition and heavy metal ions. The sensor revealed a great enhancement in selectivity coefficients for zinc ions, in comparison to the previously reported zinc sensors. The proposed sensor exhibits a Nernstian behavior (with slope of 29.1 ? 0.4 mV per decade over a wide concentration range (1.0 10-6-1.0 10-1 mol L-1 with a detection limit of 6.3 x10-7 mol L-1 (41.2 ng mL-1. It shows relatively fast response time, in the whole concentration range (< 10s, and can be used for at least 10 weeks in a pH range of 2.8-7.3. The proposed sensor was successfully used in direct determination of zinc ions in wastewater of industrial zinc electroplating companies, and also as an indicator electrode in titration with EDTA.

  7. Kohustus kannatada, et näha ja mõista. Ene Mihkelsoni ja Ingeborg Bachmanni kirjanikunägemus. The Writer’s Duty to Suffer in Order to See and Understand: The Literary Vision of Ene Mihkelson and Ingeborg Bachmann

    Directory of Open Access Journals (Sweden)

    Aija Sakova

    2012-04-01

    Full Text Available In an interview from 1971 the Austrian poet and author Ingeborg Bachmann (b 1923 said that there are phenomena that science and scientific language cannot explain. According to her these are the phenomena that belong to the realm of writers and literature. In the same year Ene Mihkelson (b 1946, who had not yet published a single book of poetry or a novel because of censorship, pondered on the role of the author within society: “The author digs under the surface and the author’s responsibility to society lies in his/her persistence, in his/her duty to suffer, to endure stress, which the people in the midst of their busy, daily lives are unable to fully grasp.” Responsibility to society and the duty to suffer and explore the deepest layers below the surface are common to both Mihkelson and Bachmann. Both writers were born and grew up in the shadow of war, violence and totalitarianism. Mihkelson was brought up in a guerrilla family in Soviet Estonia; Bachmann spent her childhood years growing up in the Nationalist-Socialist Austria and in her youth she witnessed the Second World War and its catastrophic consequences. So both of them understand that as writers they cannot overlook the events that they had, either directly or indirectly, witnessed. In an interview from 2009 Mihkelson said that the fact that she remained alive while many did not, that she was not deported to Siberia although it could have happened, has obligated her to write and reflect on what had happened. No consensus has been reached in Europe to condemn Communism as a crime against humanity, but for Estonians Communism and the 50 years of Soviet regime signify a lengthy experience of a totalitarian regime and, in spite of a possible opposition from German-speaking cultures, Communism very often equals Nazism in Estonia. According to Mihkelson, in order to understand and reflect this experience it is not sufficient to rely only on the archives, biographies and books of

  8. Computational insights into the molecular interactions of environmental xenoestrogens 4-tert-octylphenol, 4-nonylphenol, bisphenol A (BPA), and BPA metabolite, 4-methyl-2, 4-bis (4-hydroxyphenyl) pent-1-ene (MBP) with human sex hormone-binding globulin.

    Science.gov (United States)

    Sheikh, Ishfaq A; Tayubi, Iftikhar A; Ahmad, Ejaz; Ganaie, Majid A; Bajouh, Osama S; AlBasri, Samera F; Abdulkarim, Ibtihal M J; Beg, Mohd A

    2017-01-01

    Environmental contamination has been one of the major drawbacks of the industrial revolution. Several man-made chemicals are constantly released into the environment during the manufacturing process and by leaching from the industrial products. As a result, human and animal populations are exposed to these synthetic chemicals on a regular basis. Many of these chemicals have adverse effects on the physiological functions, particularly on the hormone systems in human and animals and are called endocrine disrupting chemicals (EDCs). Bisphenol A (BPA), 4-tert-octylphenol (OP), and 4-nonylphenol (NP) are three high volume production EDCs that are widely used for industrial purposes and are present ubiquitously in the environment. Bisphenol A is metabolized in the human body to a more potent compound (MBP: 4-Methyl-2, 4-bis (4-hydroxyphenyl) pent-1-ene). Epidemiological and experimental studies have shown the three EDCs to be associated with adverse effects on reproductive system in human and animals. Sex hormone-binding globulin (SHBG) is a circulatory protein that binds sex steroids and is a potential target for endocrine disruptors in the human body. The current study was done in order to understand the binding mechanism of OP, BPA, NP, and MBP with human SHBG using in silico approaches. All four compounds showed high binding affinity with SHBG, however, the binding affinity values were higher (more negative) for MBP and NP than for OP and BPA. The four ligands interacted with 19-23 residues of SHBG and a consistent overlapping of the interacting residues for the four ligands with the residues for the natural ligand, dihydrotestosterone (DHT; 82-91% commonality) was shown. The overlapping SHBG interacting residues among DHT and the four endocrine disruptors suggested that these compounds have potential for interference and disruption in the steroid binding function. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. The roles of pregn-5-ene-3β,20α-diol and 20α-hydroxy steroid dehydrogenase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat

    Science.gov (United States)

    Kuhn, N. J.; Briley, M. S.

    1970-01-01

    1. The activity of 20α-hydroxy steroid dehydrogenase in rat ovarian corpora lutea increased at least 50-fold between 2 days before and 2 days after parturition, and then fell gradually during lactation. The activity of 3β-hydroxy Δ5-steroid dehydrogenase decreased by 50% at parturition but remained constant at other times. 2. The 20α-hydroxypregn-4-en-3-one/progesterone concentration ratio in the ovary fell tenfold between 1 day before and 1 day after parturition, in contrast with the increase of the ratio for these steroids in plasma. 3. Pregnenolone was metabolized in intact cells or cell-free systems either to pregn-5-ene-3β,20α-diol and then to 20α-hydroxypregn-4-en-3-one by 20α-hydroxy steroid dehydrogenase and 3β-hydroxy Δ5-steroid dehydrogenase respectively, or directly to progesterone by the latter enzyme. The relative activities of these pathways appeared to reflect the relative amounts of the two enzymes and the concentrations of their respective coenzymes NADPH and NAD+. 4. From these and other observations it was concluded that the cessation of progesterone secretion, which precedes parturition and lactogenesis at the end of pregnancy, is partly due to the redirected metabolism of pregnenolone away from progesterone and towards 20α-hydroxypregn-4-en-3-one as the secreted end product. This is primarily the consequence of the sharp increase in the activity of 20α-hydroxy steroid dehydrogenase. This mechanism is super-imposed on the already declining rate of net Δ4-steroid release by the ovary. 5. A relationship of these pathways to subcellular compartments of luteal cells is proposed. PMID:4392955

  10. Situación de riesgo y salud de los adolescentes en el valle de los ríos Apurímac, Ene y Mantaro en Perú

    Directory of Open Access Journals (Sweden)

    Fabiola Yeckting Vilela

    Full Text Available Se presenta el diagnóstico de las condiciones de vida de los adolescentes varones y mujeres en la zona del valle de los ríos Apurímac, Ene y Mantaro (VRAEM, quienes atraviesan situaciones de riesgo y vulnerabilidad social y sexual debido a los altos niveles de producción de la hoja de coca y el contexto del narcotráfico, que crean la ilusión del rápido ascenso social. A partir de ello, es necesario preguntarse ¿cuáles son las condiciones de vida y situaciones de riesgo de los adolescentes en el VRAEM? y ¿cuáles son las alternativas para una mejora de su situación desde el acceso a la educación y los programas de atención de su salud? Esta situación de riesgo es el resultado de las relaciones desiguales de género, violencia sexual, deserción escolar, embarazo adolescente, consumo de alcohol y drogas, así como de la falta de oportunidades como consecuencia de la participación en la economía de la coca y el narcotráfico entre los adolescentes en el VRAEM. Finalmente, se presentan los resultados de la atención de profesionales de los centros de salud para favorecer la consejería en salud sexual y reproductiva y el acceso a los servicios de salud del Programa Vida Adolescente, como oportunidad de vincular los contenidos del currículo de educación y las metas de cumplimiento de este sector, visibilizando la necesidad de un enfoque de interculturalidad e igualdad de género en el acceso a la salud y la educación de los adolescentes.

  11. Androgen and Progesterone Receptors Are Targets for Bisphenol A (BPA), 4-Methyl-2,4-bis-(P-Hydroxyphenyl)Pent-1-Ene--A Potent Metabolite of BPA, and 4-Tert-Octylphenol: A Computational Insight.

    Science.gov (United States)

    Rehan, Mohd; Ahmad, Ejaz; Sheikh, Ishfaq A; Abuzenadah, Adel M; Damanhouri, Ghazi A; Bajouh, Osama S; AlBasri, Samera F; Assiri, Mansour M; Beg, Mohd A

    2015-01-01

    Exposure to toxic industrial chemicals that have capacity to disrupt the endocrine system, also known as endocrine disrupting chemicals (EDCs), has been increasingly associated with reproductive problems in human population. Bisphenol A (BPA; 4,4'-(propane-2,2-diyl)diphenol) and 4-tert-octylphenol (OP; 4-(1,1,3,3-tetramethylbutyl)phenol) are among the most common environmental contaminants possessing endocrine disruption properties and are present in plastics, epoxy resins, detergents and other commercial products of common personal and industrial use. A metabolite of BPA, 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) is about 1000 times more biologically active compared to BPA. Epidemiological, clinical, and experimental studies have shown association of BPA and OP with adverse effects on male and female reproductive system in human and animals. The endocrine disruption activity can occur through multiple pathways including binding to steroid receptors. Androgen receptor (AR) and progesterone receptor (PR) are critical for reproductive tract growth and function. Structural binding characterization of BPA, MBP, and OP with AR and PR using molecular docking simulation approaches revealed novel interactions of BPA with PR, and MBP and OP with AR and PR. For BPA, MBP, and OP, five AR interacting residues Leu-701, Leu-704, Asn-705, Met-742, and Phe-764 overlapped with those of native AR ligand testosterone, and four PR interacting residues Leu-715, Leu-718, Met-756, and Met-759 overlapped with those of PR co-complex ligand, norethindrone. For both the receptors the binding strength of MBP was maximum among the three compounds. Thus, these compounds have the potential to block or interfere in the binding of the endogenous native AR and PR ligands and, hence, resulting in dysfunction. The knowledge of the key interactions and the important amino-acid residues also allows better prediction of potential of xenobiotic molecules for disrupting AR- and PR

  12. Androgen and Progesterone Receptors Are Targets for Bisphenol A (BPA, 4-Methyl-2,4-bis-(P-HydroxyphenylPent-1-Ene--A Potent Metabolite of BPA, and 4-Tert-Octylphenol: A Computational Insight.

    Directory of Open Access Journals (Sweden)

    Mohd Rehan

    Full Text Available Exposure to toxic industrial chemicals that have capacity to disrupt the endocrine system, also known as endocrine disrupting chemicals (EDCs, has been increasingly associated with reproductive problems in human population. Bisphenol A (BPA; 4,4'-(propane-2,2-diyldiphenol and 4-tert-octylphenol (OP; 4-(1,1,3,3-tetramethylbutylphenol are among the most common environmental contaminants possessing endocrine disruption properties and are present in plastics, epoxy resins, detergents and other commercial products of common personal and industrial use. A metabolite of BPA, 4-Methyl-2,4-bis(4-hydroxyphenylpent-1-ene (MBP is about 1000 times more biologically active compared to BPA. Epidemiological, clinical, and experimental studies have shown association of BPA and OP with adverse effects on male and female reproductive system in human and animals. The endocrine disruption activity can occur through multiple pathways including binding to steroid receptors. Androgen receptor (AR and progesterone receptor (PR are critical for reproductive tract growth and function. Structural binding characterization of BPA, MBP, and OP with AR and PR using molecular docking simulation approaches revealed novel interactions of BPA with PR, and MBP and OP with AR and PR. For BPA, MBP, and OP, five AR interacting residues Leu-701, Leu-704, Asn-705, Met-742, and Phe-764 overlapped with those of native AR ligand testosterone, and four PR interacting residues Leu-715, Leu-718, Met-756, and Met-759 overlapped with those of PR co-complex ligand, norethindrone. For both the receptors the binding strength of MBP was maximum among the three compounds. Thus, these compounds have the potential to block or interfere in the binding of the endogenous native AR and PR ligands and, hence, resulting in dysfunction. The knowledge of the key interactions and the important amino-acid residues also allows better prediction of potential of xenobiotic molecules for disrupting AR- and PR

  13. Crystal structures of three anhydrous salts of the Lewis base 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU with the ring-substituted benzoic acid analogues 4-aminobenzoic acid, 3,5-dinitrobenzoic acid and 3,5-dinitrosalicylic acid

    Directory of Open Access Journals (Sweden)

    Graham Smith

    2016-03-01

    Full Text Available The anhydrous salts of the Lewis base 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU with 4-aminobenzoic acid [1-aza-8-azoniabicyclo[5.4.0]undec-7-ene 4-aminobenzoate, C9H17N2+·C7H6NO2− (I], 3,5-dinitrobenzoic acid [1-aza-8-azoniabicyclo[5.4.0]undec-7-ene 3,5-dinitrobenzoate, C9H17N2+·C7H3N2O6−, (II] and 3,5-dinitrosalicylic acid (DNSA [1-aza-8-azoniabicyclo[5.4.0]undec-7-ene 2-hydroxy-3,5-dinitrobenzoate, C9H17N2+·C7H3N2O7−, (III] have been determined and their hydrogen-bonded structures are described. In both (II and (III, the DBU cations have a common disorder in three of the C atoms of the six-membered ring moieties [site-occupancy factors (SOF = 0.735 (3/0.265 (3 and 0.686 (4/0.314 (4, respectively], while in (III, there is additional rotational disorder in the DNSA anion, giving two sites (SOF = 0.72/0.28, values fixed for the phenol group. In the crystals of (I and (III, the cation–anion pairs are linked through a primary N—H...Ocarboxyl hydrogen bond [2.665 (2 and 2.869 (3 Å, respectively]. In (II, the ion pairs are linked through an asymmetric three-centre R12(4, N—H...O,O′ chelate association. In (I, structure extension is through amine N—H...Ocarboxyl hydrogen bonds between the PABA anions, giving a three-dimensional structure. The crystal structures of (II and (III are very similar, the cation–anion pairs being associated only through weak C—H...O hydrogen bonds, giving in both overall two-dimensional layered structures lying parallel to (001. No π–π ring associations are present in any of the structures.

  14. 7-{[2-(4-Hydroxyphenylmethylidene]amino}-1,3-thiazol-4-yl-2-(methoxyiminoacetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-ylsulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

    Directory of Open Access Journals (Sweden)

    Ghulam Fareed

    2012-05-01

    Full Text Available Novel 7-{[2-(4-hydroxyphenylmethylidene]amino}-1,3-thiazol-4-yl-2-(methoxyiminoacetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-ylsulfanyl]methyl}-8-oxo-5-thia-1azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid was prepared by condensation of ceftriaxone disodium (1 with 4-hydroxybenzaldehyde (2 in ethanol under reflux conditions for 3–4 h. The structure of synthesized compound was elucidated using LCMS, 1H-NMR, and CHN techniques.

  15. Aproximación a la situación de salud en tres comunidades Asháninkas ubicadas en las cuencas del río Tambo y Ene, 2006

    Directory of Open Access Journals (Sweden)

    Carolina Tarqui-Mamani

    2009-01-01

    Full Text Available En mayo de 2006 se realizó un estudio transversal en tres comunidades Asháninkas ubicadas en las cuencas de los ríos Tambo y Ene, para describir su situación de salud. Se definió la situación salud sobre la base de cinco indicadores: prevalencia de la desnutrición infantil, enfermedades diarreicas agudas (EDA, infecciones respiratorias agudas (IRA, mortalidad materna y mortalidad infantil. Se interrogó a los padres o madres de familia acerca de defunciones en menores de 1 año, defunciones maternas, casos de EDA e IRA. Se evaluó el estado nutricional mediante la medición del peso y la talla en niños de 0 a 6 años y se observó el estado de protección vacunal en los carnés de vacunación. Se realizó 53 entrevistas a los padres y se evaluó a 83 niños en las comunidades de Samaniato, Tziquireni y Mayapo. No se reportó muertes maternas ni infantiles. La desnutrición global alcanzó 43,3% y fluctúa entre 53 a 57% entre los 12 y los 47 meses y aumenta a 58,8% después de los 48 meses. La desnutrición crónica alcanzó al 78,3% de niños evaluados. Los padres reportaron que 53,1% de los niños presentaron un episodio de EDA y 57% de IRA. 98,9% de los niños mayores de un año estuvieron protegidos. Los resultados encontrados permiten una aproximación a la situación de salud en las comunidades Asháninkas, lo cual debe favorecer el diseño de programas de intervención focalizados o acciones de ayuda nutricional dirigidas a los niños de dicha comunidad.

  16. Modernne kastmaja Nõmmel / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    1999-01-01

    Projekteerija: arhitektuuribüroo Mark & Tamm. Konstruktiivne osa: inseneribüroo Randväli Karema. Arhitektid Ülar Mark, Kalle Komissarov. Kahekorruseline maja Vabaduse pst. ääres on mahutatud puude vahele kitsale alale. Kommenteerib Ü. Mark.

  17. Cultural Trauma and Life Stories / Ene Kõresaar

    Index Scriptorium Estoniae

    Kõresaar, Ene

    2007-01-01

    Aili Aarelaid-Tarti 15-aastase uuringu tulemused raamatus "Cultural Trauma and Life Stories", Hesinki, Kikimora Publications, 2006. Uuritud on kolme suurt rahvusgruppi 1940-test tingitud trauma kontekstis: eestlased kodumaal, eestlased eksiilis ja venekeelne rahvusgrupp Eestis postsovetlikus diskursuses

  18. Mida lugeja raamatukogult tegelikult ootab / Ene Riet

    Index Scriptorium Estoniae

    Riet, Ene, 1954-

    2011-01-01

    4. teadus- ja erialaraamatukogude päev toimus 21. oktoobril 2011 Eesti Muusika- ja Teatriakadeemias. Teadusraamatukogu aasta teo auhinna pälvis Urmas Sinisalu tulemusliku ja innovaatilise töö eest raamatukogude infosüsteemi ESTER arendamisel. Erialaraamatukogu aasta teo auhinna sai TÜ ajakirjanduse ja kommunikatsiooni instituudi raamatukoguhoidja Maio Vaniko raamatukogundust arendava tegevuse eest

  19. Uus eesti disain / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2009-01-01

    2009. a. disainiöö raames toimunud Eesti Disainerite Liidu algatatud konkursi "Eesti disain ja elukeskond 2009" disainikategooria kümne finalisti tööde tutvustus. 1. koha sai moodulrattahoidja "Rohi" (disain: Keha3), 2. koha vurr-tool "Kiirendi" (disain: Jaanus Orgusaar), 3. koha lastemööbel "Smart kid" (disain: Pavel Sidorenko, Heiki Must)

  20. Vaesusriski muutused Eestis / Ene-Margit Tiit

    Index Scriptorium Estoniae

    Tiit, Ene-Margit, 1934-

    2006-01-01

    Seoses Eesti majanduse kiire arenguga tellis sotsiaalministeerium 2005. aastal uue tarbimiskaalude hinnangu, mille aluseks olid leibkonna eelarvehinnangu andmed aastaist 2000-2004 ning hinnati erineva struktuuriga leibkondade tarbimiskulutusi. Diagrammid. Graafikud

  1. Eesti Etnograafia Ring Kanadas / Ene Runge

    Index Scriptorium Estoniae

    Runge, Ene, 1919-1999

    1993-01-01

    Etnograafia Ring looodi 1971.a ja on pidevalt õpetanud käsitööd, pidanud loenguid eesti ja inglise keeles, korraldanud näitusi ja loonud eesti sektsiooni Royal Ontario Museumi ja Canadian National Museumi juurde kultuurivara säilitamiseks. Seltsi 20. aastapäevaks oli välja antud 61 õppekirja, lisaks õpetused ajakirjas "Triinu" ja õppefilmid, fotod ja diapositiivid, abi on antud samasugustele ringidele Rootsis ja Austraalias, ERM-ile saadeti 1991. a üle 200 rahvakultuuri eseme

  2. Seadusemuudatused, mis teevad elu paremaks / Ene Kaups

    Index Scriptorium Estoniae

    Kaups, Ene, 1963-

    2008-01-01

    2008. aastal jõustuvatest seadusemuudatustest. Ilmunud ka Koit 7. veeb. 2008, lk. 6 ; Lääne Elu 7. veeb. 2008, lk. 2 ; Hiiu Leht 8. veeb. 2008, lk. 2 ; Järva Teataja 9. veeb. 2008, lk. 2 ; Türi Rahvaleht 8. veeb. 2008, lk. 4, pealkiri kujul: Seadusemuudatustest ; Meie Maa 15. veeb. 2008, lk. 2 ; Sakala 15. veeb. 2008, lk. 2, pealkiri kujul: Käesolev aasta toob hulga olulisi muudatusi ; Sõnumitooja 27. veeb. 2008, lk. 2 ; Valgamaalane 26. veeb. 2008, lk. 2

  3. Teenindusprotsessi juhtides alustagem naeratusest! / Ene Riet

    Index Scriptorium Estoniae

    Riet, Ene, 1954-

    2009-01-01

    Eesti Rahvusraamatukogus algasid 2009 a. raamatukogupäevad 20. oktoobril kõnekoosolekuga, kus räägiti raamatukoguteenuse kvaliteediküsimustest ja esitleti RR-i toimetisi "Teenuse kvaliteet - raamatukogutöö tulemuslikkuse näitaja", mille koostaja on Anne Veinberg

  4. Kas 270 rahvaraamatukogust piisab? / Ene Riet

    Index Scriptorium Estoniae

    Riet, Ene, 1954-

    2016-01-01

    Haldusreformi mõjust rahvaraamatukogude võrgule. Uuringust "Era- ja avalike teenuste ruumilise paiknemise ja kättesaadavuse tagamisest ja teenuste käsitlemisest maakonnaplaneeringute käigus" (2015)

  5. Tohuvabohu kodukujunduses / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Tänapäeva Eesti kodukujundusest. Illustratsiooniks 90ndate kolm eramut : neomodernistlik Sinine Maja neominimalistliku interjööriga (Kolm Pluss Üks Arhitektid, arhitekt M. Kaasik), modernistlik villa Sumberg - (Urbel & Peil, arhitekt E. Urbel, sisekujundaja T. Mähar), ökosugemetega modernistlik villa Koger (arhitekt V. Sova, sisearhitektid A. Teigar, M. Press). Kommenteerivad Mart Kalm, Toivo Raidmets. Terminite selgitus.

  6. Maia Laul / Maia Laul ; interv. Ene Ammer

    Index Scriptorium Estoniae

    Laul, Maia, 1921-2009

    1998-01-01

    Maia Laul eriala omandamisest, õppejõududest. Lõpetas 1949. a. Tallinna Riikliku Tarbekunsti Instituudi. Alar Kotli käealusena "Estonia" teatri taastamisprojekti juures. Peeter Tarvase ja August Volbergiga ENSV paviljponi kujundamas Moskvas VDNHs. Töötamisest ARSis. Sisearhitektuur ja monumentaalkunst (koostöö Eva Jänesega). Esinemistest näitustel "Ruum ja vorm". Ühiskondlike hoonete sisekujundustest. Vanaturu apteek (klaasigraafika Tiit Jürna)

  7. Riik arhitektuuritellijana / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2010-01-01

    Näidete varal Riigi Kinnisvara AS-i korraldatud projekteerimise hangetest, mil välja valiti odavaim pakkumine. Valminud Rakvere politseihoonest ning Jõgeva kohtu- ja politseihoonest. Mudelprojekteerimise (BIM) nõudest. Riigihankest kui salastatud protsessist. Sunnist loobuda autoriõigusest. Riigihankega ühendatud arhitektuurikonkursist

  8. Professor Pekka Puska loengud / Ene Indermitte

    Index Scriptorium Estoniae

    Indermitte, Ene, 1967-

    2004-01-01

    Soome Rahvatervishoiu Instituudi direktor, Põhja-Karjala projekti juht prof Pekka Puska peab Tartu ülikoolis loengu "The North Karelia Projekt in Finland and lessons for global chronic disease prevention"

  9. Küberjulgeolekule teed rajades / Ene Ergma

    Index Scriptorium Estoniae

    Ergma, Ene, 1944-

    2007-01-01

    Riigikogu esimees analüüsib aprillisündmustega kaasnenud küberrünnakute kui ühe terrorismi erivormi tagamaid, toob välja vajaduse kujundada küberrünnakute suhtes Euroopa Liidus ja NATO-s ühtne poliitika

  10. 968-IJBCS-Article-Ene Pascal Chuka

    African Journals Online (AJOL)

    T60

    were obtained from the diarrheic children 18 (21.7%) as against 5(10%) from the control. While EPEC (3.6% vs 0%) and EAEC (10.8% vs 4%) strains were significantly associated with diarrhea (P<0.05), EPEC was isolated only in children <3 years old while EAEC was more distributed on the age ranges studied. There was.

  11. Hantzsch Synthesis of 2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(o-methoxyphenyl-1,4-dihydropyridine; a Novel Cyclisation Leading to an Unusual Formation of 1-Amino-2-methoxycarbonyl-3,5-bis(o-methoxyphenyl-4-oxa-cyclohexan-1-ene

    Directory of Open Access Journals (Sweden)

    Vladimir Vinković

    2007-11-01

    Full Text Available Hantzsch condensation of two equivalents of methyl-3-aminocrotonate with (m-and p-methoxybenzaldehyde afforded the expected products 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(m-methoxyphenyl-1,4-dihydropyridine and 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(p-methoxyphenyl-1,4-dihydropyridine, whereas o-methoxy-benzaldehyde produced mainly 1-amino-2-methoxycarbonyl-3,5-bis(o-methoxy-phenyl-4-oxa-cyclohexan-1-ene. The structure of the product, not previously reported in theliterature, was determined by 1D and 2D NMR spectra and its MS fragmentation. This isthe first example of cyclisation leading to a substituted pyran rather than 1,4-DHP undertypical Hantzsch reaction conditions. A plausible mechanism for its formation ispostulated.

  12. Ene-ene-yne Reactions: Activation Strain Analysis and Role of Aromaticity

    NARCIS (Netherlands)

    Fernandez, I.; Bickelhaupt, F.M.; Cossío, F.P.

    2014-01-01

    The trend in reactivity of the thermal cycloisomerization reactions of 1,3-hexadien-5-ynes, A=B-C=D-E≡F, were explored and analyzed by using density functional theory at the M06-2X/def2-TZVPP level. These reactions proceed through formally aromatic transition states to form a bent-allene

  13. ALT ÇENE KAYNAKLI İSKELETSEL SINIF II OLGULARDA YÜZ DERİNLİĞİNİN SEFALOMETRİK OLARAK DEĞERLENDİRİLMESİ - THE CEPHALOMETRIC ASSESMENT OF THE FACIAL DEPTH IN SKELETALLY SINIF II INDIVIDUALS WITH MANDIBULAR DEFICIENCY

    OpenAIRE

    ALAKUŞ SABUNCUOĞLU, Fidan; BENGİ, Osman; ÖLMEZ, Hüseyin

    2012-01-01

    ÖZETBu çalışmada, alt çene kaynaklı iskeletsel Sınıf II maloklüzyon gösteren hastalarda ortalama yüz derinliği tespit edilerek, bu mesafe ile ön yüz yüksekliği arasındaki ilişki araştırılmıştır. Bu amaçla condylion noktası ile nasion noktasının Frankfort Horizontal düzlemindeki (FH) izdüşümleri arasındaki mesafe Yüz Derinlik Mesafesi (Co'-N') olarak tanımlanmış ve bu mesafe ile ön yüz yüksekliği karşılaştırılarak belirli bir oran saptanmaya çalışılmıştır.Anahtar Kelimeler: Yüz derinliği, Sını...

  14. Põllumajandussaaduste eksport ja import Eestis 1995. aastal / Ene Maadvere

    Index Scriptorium Estoniae

    Maadvere, Ene, 1948-

    1996-01-01

    Tabelid: Kaupade eksport ja import Eestis; Põhiliste kaubagruppide osatähtsuse muutumine toidukaupade ekspordis; Hinnad; Mõnede toidukaupade eksport 1995.a. võrreldes 1994.a.; Imporditud toidukaupade struktuur võrreldes 1995.a.; Nisuhind Chicago börsil. Diagrammid: Liha-piima tootmine, tarbimine, eksport ja tonnides; Põllumajandussaaduste eksport 1995.a. riikide lõikes

  15. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    DEFF Research Database (Denmark)

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet). Rappor...

  16. Tööjuhendid loovuse arendajana / Ene Lind

    Index Scriptorium Estoniae

    Lind, Ene

    2001-01-01

    Loovuse arendamine tööõpetuse ja käsitöö tunnis. Katsest Tallinna koolide 2. ja 4. klasside õpilaste seas, milles katsetati kaht töö raskusastme ning kasutatavate materjalide ja töövahendite poolest erinevat tööjuhendit. Katse järel viidi läbi küsitlus, kus lapsed andsid hinnangu ja kommenteerisid tööjuhendi järgi iseseisvalt töötamist tööõpetuse tunnis

  17. Minimalismi asemele hiilib barokk / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    1999-01-01

    Trendikatest jõulukompositsioonidest. Nõu annavad Stockholmi kuusekaunistamise maailmameistrivõistluse maailmameistrid Taivo Piller ja Mart Haber. T. Pilleri parim õpetaja - norra lilleseadja Linda Johansen.

  18. Iseloomuga majad, vol 1 / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2008-01-01

    Eesti Arhitektide Liidu korraldatud konkursi "Eramu 2006-2007" nominendid: 1. Funkvilla Nõmmel (arhitekt Andres Ringo); 2. Villa Tabasalus (arhitekt Tiit Trummal); 3. Sõlmes alumiiniummaja (arhitektid Peeter Pere, Urmas Muru); 4. Etnomodernne palkmaja (arhitektid Tauno Aadma, Laur Pihel); 5. Villa Kurepesa Pirita jõekäärus (arhitekt Kalle Rõõmus); 6. Vaskvilla Võrus (arhitekt Karmo Tõra)

  19. Iseloomuga majad, vol 2 / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2008-01-01

    Eesti Arhitektide Liidu korraldatud konkursi "Eramu 2006-2007" nominendid: 1. Vonklev arhitektimaja (arhitekt Karmo Tõra); 2. Betoonmaja Kloogarannas (arhitektid Laur Pihel, Tauno Aadma); 3. Funktalu Jõgisool (arhitekt Jaak Huimerind); 4. Villa Kakumäel (arhitekt Tiina Kaljundi); 5. Räästamaja Suurupis (arhitekt Raul Vaiksoo); 6. Klotsidest maja (arhitekt Eero Palm, kaasautor Kristiina Ott)

  20. Phytochemical Screening and Characterization of Olean-18-ene ...

    African Journals Online (AJOL)

    http://dx.doi.org/10.4314/star.v4i1.15 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER RESOURCES... for Researchers · for Journals · for Authors · for Policy Makers ...

  1. Tuul väljal / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet

    1997-01-01

    Arvustus: Woolf, Virginia. Esseed/ inglise k. tlk. Malle Talvet, Jaak Rähesoo. Tallinn : Hortus Litterarum, 1997; Woolf, Virginia. Orlando : elulugu / inglise k. tlk. Riina Jesmin. Tallinn : Perioodika, 1997. (Loomingu Raamatukogu; 31-34)

  2. Eesti vajab rohkem doktoreid / Raul Eamets, Ene-Margit Tiit

    Index Scriptorium Estoniae

    Eamets, Raul, 1964-

    2008-01-01

    Teadmistepõhisest majandusest, doktorikraadiga spetsialistide vajadusest, doktorikraadi taotlemisest, teadus- ja arendustegevuse rahastamisest, rahvusvahelise doktorite karjääriuuringu Eesti katseprojekti (CDH) tulemustest

  3. Põllumajandussaaduste turg : [1994-2003 Eestis] / Ene Maadvere

    Index Scriptorium Estoniae

    Maadvere, Ene, 1948-

    2004-01-01

    Ilmunud ka: Agriculture and rural development : overview 2003/2004. - Tallinn, 2004, lk. 124-132. Põllumajandussaaduste ekspordimaht vähenes 2003. a. eelmise aasta sama perioodiga võrreldes 0,4%, importmaht aga suurenes 7%. Tabelid. Diagrammid. Graafikud

  4. Lapsevanemate osalemine koolielus ja rahulolu kooliga / Eda Heinla, Ene Pill

    Index Scriptorium Estoniae

    Heinla, Eda, 1953-

    2008-01-01

    Artikkel analüüsib lapsevanemate koostööd kooliga, hinnanguid koolitöös osalemise võimalustele, nägemusi kooli hoolekogu ülesannetest ning rahulolu lapse kooli suhtes. Artikkel põhineb Tallinna üldhariduskoolide õpilaste vanemate küsitlusel

  5. Sotsiaal-majanduslik staatus tervise tausttegurina / Margo Kikas, Ene Lausvee

    Index Scriptorium Estoniae

    Kikas, Margo

    2008-01-01

    Uuringust seoste kohta Eesti inimeste tunnetatud tervise ning sotsiaal-majandusliku ja psühhosotsiaalse seisundi vahel. Uuring tugineb Tallinna Ülikooli sotsiaaltöö eriala üliõpilaste poolt aastatel 2001-2002 tehtud anonüümsel ankeetküsitlusel põhiliselt toimetulekuraskuste, krooniliste haiguste, puudega või riskikäitumisega isikute seas

  6. Läänemeri vs Nord Stream / Ene Kaups

    Index Scriptorium Estoniae

    Kaups, Ene, 1963-

    2009-01-01

    Riigikogu võttis vastu avalduse Läänemerre kavandatava gaasijuhtmega seotud keskkonnariskidest, kus avaldatakse muret, et Nord Stream AG poolt algatatud gaasijuhtme projekti rahvusvahelise keskkonnamõju hinnangutes ei ole piisavalt arvestatud kõigi seonduvate keskkonnariskidega

  7. Ülikool ja haridus postajastul / Ene Grauberg

    Index Scriptorium Estoniae

    Grauberg, Ene, 1944-

    2006-01-01

    Informatsiooni kesksest rollist postindustriaalses ühiskonnas, ülikooli ja rakenduskõrgkooli teisenenud funktsioonidest, kõrghariduse uutest trendidest, õppejõu ja üliõpilase suhete muutumisest Pransuse filosoofi Jean-Francois Lyotardi interpreteeringuga

  8. ŽENE I SPORT U CRNOJ GORI

    Directory of Open Access Journals (Sweden)

    Cheryl Cooky

    2011-08-01

    Full Text Available This paper is part of a larger study that identifies who plays sport in Montenegro, and the factors (family, education, economic, religious, cultural stereotypes, and so on that contribute to girls and women’s participation in sport or that limit girls and women’s participation in sport. This study is the first evidencebased research assessing the current status of girls and women’s sport participation in Montenegro, at all institutional levels. Using mixed-methodologies (quantitative assessment, survey data and qualitative focus group interviews this study will determine the numbers of girls and women participating in sport, as compared to boys and men in similar demographic categories, and to examine why girls and women do or do not participate in sport and what are their experiences in sport. Initial findings from the demographic assessment of sport in Montenegro illustrate overall gender disparities in sport participation in the 7 most popular sports; the majority of athletes, coaches, managers and decision-makers, medical staff, referees and sport delegates were men. We found the greatest gender imbalance in soccer and basketball, which were overwhelmingly male-dominated, and the greatest gender parity in handball and volleyball- and in some cases there were more female participants than male participants in these sports. We also examined overall trends in gender and sport participation across the different geographical regions, which were similar. However, there were differences in the types of sports men and women played in the different regions, which may indicate that some sports were more popular, or accepted, or easier to access for women in the central part of the country while other sports were more popular, or accepted or easier to access for women in the northern and southern regions. The project is a collaborative partnership with US- and Montenegro based scholars, the International Olympic Committee, the Montenegrin Olympic Committee, the United Nations Development Program, the Office for Gender Equality of the Ministry for Human and Minority Right of Montenegro, and NGO Inovativnost. Reflections and insights on multi-institutional partnerships in the study gender and sport participation will be offered.

  9. 30ndad aastad Euroopa rõivamoes / Ene Lamp

    Index Scriptorium Estoniae

    Lamp, Ene

    1984-01-01

    Mood tegeles peamiselt naisega. Moekunsti inspireeris kujutav ja rahvakunst. Ameerika moe mõju, moe muutumine demokraatlikumaks, iluideaalid, elulaad, soengud, kübarad, jalanõud, tekstiilid, moevärvid, siluetid, lihtsus ja luksus 30. aastate I poole moes, sõja mõjud moes jm.

  10. Ainenõukogu tähelepanekuid / Ene Laanes

    Index Scriptorium Estoniae

    Laanes, Ene

    2003-01-01

    Üleriigiline kehalise kasvatuse ainenõukogu peab vajalikuks juhtida haridusametnike, koolijuhtide ja kooli omanike tähelepanu kehalise kasvatuse ainekava läbiviimisel üles kerkinud probleemidele: meditsiinilisse erigruppi kuuluvate õpilaste hindamine kehalise kasvatuse aines, kehalise kasvatuse tunniks vajalikud harjutuspaigad ja vahendid, nädalatundide arv

  11. Hüdra aastasada / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet

    1997-01-01

    Arvustus: Galsworthy, John. Peatüki lõpp : Üle jõe / tlk. Jüri ja Liisi Ojamaa. Tallinn : Eesti Raamat, 1997; Amis, Kingsley. qnneseen Jim / tlk. Urve Hanko. Tallinn : Eesti Raadio, 1997; Boyd, William. Sinine pärastlõuna / tlk. Virve Krimm. Tallinn : Varrak, 1997. Briti XX saj. kirjanduse ülevaade

  12. Võrumaa mitmekesisuse võlu / Ere Raag ; intervjueerinud Ene Riet

    Index Scriptorium Estoniae

    Raag, Ere

    2015-01-01

    Võrumaa Keskraamatukogu pearaamatukoguhoidja räägib, kuidas ja miks valis ta oma erialaks raamatukogunduse, kus ja kellena ta on töötanud ning mida on raamatukogundus talle andnud. Arutletakse ka raamatukogunduse ning raamatukoguhoidja tuleviku üle

  13. Modernse arhitektuuri ja okupatsioonimuuseumi liit / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2001-01-01

    Okupatsioonimuuseumi ideest ja teostamisest. Avaliku arhitektuurivõistluse "Lähimineviku okupatsioonide muuseum" võitjad: I preemia: Indrek Peil, Siiri Vallner, II preemia Tiina Teng, Peeter Loo, III preemia Reio Avaste (AS Arhitektuuribüroo Eek & Mutso), ostupreemia: Margus (?) Kaasik, Kalle Komissarov, Andres Ojari, Indrek Tiigi, Ilmar Valdur (Arhitektuuribüroo Kolm Pluss Üks OÜ), ostupreemia: Andres Kask

  14. 500-tonniste muldseintega elamu / Ene Läkk, Helen Urbanik

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Arhitekt Rick Joy projekteeritud arst John Palmeri villa USAs Arizona osariigis, Santa Catalina mäestiku jalamil. Hoone ühes osas asuvad perekonna eluruumid, teine on avatud ruum. Pressitud muldseinad ja liblikatiiva kujulised terasest katusesiilud jäljendavad ümbritseva maastiku vorme. Suuri seina- ja aknapindu katab raamimata klaas.

  15. Preparation of Novel Hydrolyzing Urethane Modified Thiol-Ene Networks

    Science.gov (United States)

    2011-10-25

    water to cleave covalent bonds and result in the degradation of the local network. If designed to erode at the coating-water interface rather than in...chloroform at 50 wt %. The dibutyltin dilaurate catalyst was added at 0.1 wt % of total solids to the ethylene glycol vinyl ether solution. The...elastomers, copolymers and ionomers . Prog. Mater. Sci. 2007, 52, 915-1015. 19. Bruchmann, B. Dendritic polymers based on urethane chemistry—Syntheses

  16. Puhtus ja kord majas ning mõtetes / Ene Vool

    Index Scriptorium Estoniae

    Vool, Ene, 1948-

    2007-01-01

    Kalle Rõõmuse projekteeritud inimese bioenergiast lähtuvast eramust, kus raudse järjekindlusega kasutati energeetilisest seisukohast ülimalt inimsõbralikke loodusmaterjale - mida vähem materjale, seda vähem väljamõjusid. Sisearhitekt oli Terje Kivist. Kalle Rõõmuse kommentaar

  17. Lapse ülalpidamise hind / Ene-Margit Tiit

    Index Scriptorium Estoniae

    Tiit, Ene-Margit, 1934-

    2005-01-01

    Tutvustav artikkel sotsiaalministeeriumi tellimusel läbiviidud uuringust, mille eesmärgiks oli välja töötada lapse kõikidest vajadustest lähtuv ühtne metoodika lapse ülalpidamiskulude arvutamiseks ühes kuus. Tabelid. Diagrammid. Vt. ka lk. 15-16: Kaplan, Signe. Metoodika kasutamisvõimalusi

  18. Fluoriidid Eesti elanike joogivees / Astrid Saava, Ene Indermitte

    Index Scriptorium Estoniae

    Saava, Astrid, 1938-

    2007-01-01

    Eesti elanike joogivee-uuringust, mis tehti 2004. aastal Eesti Stomatoloogia Seltsi tellimisel. Lisad: Eesti elanike joogivee fluoriidisisalduse kaart. Elanike jaotus tarbitava joogivee fluoriidisisalduse alusel maakonniti

  19. Euroopa kõige ilusamad hotellid / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2007-01-01

    Hotel Puerta America Madridis, mille on kujundanud 19 maailmakuulsat disainerit. Hotell Luzernis, kus laekujunduses on kasutatud filmikaadreid. Hotell Lute Suites Hollandis. Duomo Hotel Riminis, kujundus Ron Arad'ilt. Kruisherenhotel Maastrichtis

  20. Otsused andmekandjate kohta kriminaalmenetluses: proportsionaalsusnõudega arvestamine / Eneli Laurits

    Index Scriptorium Estoniae

    Laurits, Eneli

    2016-01-01

    Riigikohtu lahendist nr. 3-1-1-57-12, proportsionaalsuse nõude rakendamisest asitõendi (andmekandja) täieliku hävitamise korral alamaastmete kohtute praktikas. Sisaldab 2013-2015 aastate asjakohast kohtupraktikat

  1. Videomuinasjutt algastme eesti keele tundi : miks ka mitte? / Ene Peterson

    Index Scriptorium Estoniae

    Peterson, Ene

    2002-01-01

    Rets. : Tungal, Leelo. Videomuinasjutt "Printsess Mari ja konn Konrad" [Videosalvestis] = A fairytale on video "Princess Mari and frog Konrad". - Tallinn : Elav Teadus, 1993. - 1 videokassett (VHS) (120 min) + 1 raamat (32 lk.)

  2. Kooli tehnoloogiaõpetus tuleb atraktiivseks muuta / Ene Lind

    Index Scriptorium Estoniae

    Lind, Ene, 1954-

    2010-01-01

    Üleeuroopalisest tehnoloogiaõppe edendamise projektist "Understanding and Providing a Developmental Approach to Technology Education" - UPDATE ("Tehnoloogiaõpetuse arenguvõimaluste mõistmine ning rakendamine"). Jyväskylä Ülikooli juhtimisel tegid koostööd 16 Euroopa haridus- ja teadusasutust, Eestit esindas Tallinna Ülikooli tööõpetuse osakond koos Eesti Tehnoloogiakasvatuse Liiduga

  3. People in Ida-Virumaa : between two cultures / Ene Must

    Index Scriptorium Estoniae

    Must, Ene

    2002-01-01

    Peamistest probleemidest Ida-Virumaal, Sillamäel ja Narvas. Kohalike elanike seas läbi viidud Eesti sotsioloogide, Eesti integratsioonifondi ja Saar Polli uuringufirma uurimusest, kus uuriti nende sidemeid naaberriikidega, majanduslikku olukorda ning nende võimalikku elukoha muutust seoses majandusliku olukorraga Eestis ja liitumisega EL-iga. Kokkuvõtted uuringu tulemustest. Diagrammid

  4. Eesti kajas saksa Baltoscandalil / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2003-01-01

    12. juunil alanud saksa festivalist Transeuropa 2003, kus esinejateks ka Von Krahli Teater lavastusega "Pirates", K. Essenson sooloetendusega "So far, so good" ja kunstikriitik ja -kuraator A.Härm performance'iga "Be drunk, be very, very drunk"

  5. Sistema reprodutivo e polinização de Lepidagathis sessilifolia (Pohl Kameyama ex Wassh. & J.R.I. Wood (Acanthaceae, em remanescente florestal da região sudoeste de Mato Grosso, Brasil Breeding system and pollination of Lepidagathis sessilifolia (Pohl Kameyama Wassh ex. & J.R.I.Wood (Acanthaceae in remnant forest in the southwest region of Mato Grosso, Brazil

    Directory of Open Access Journals (Sweden)

    Celice Alexandre Silva

    2012-09-01

    Full Text Available O gênero Lepidagathis apresenta distribuição pantropical com cerca de 100 espécies. No Brasil ocorrem 16 espécies, a maioria nas regiões Centro - Oeste e Sudeste. O estudo foi realizado em sub - bosque de remanescente florestal do município de Tangará da Serra - MT e teve como objetivo analisar a fenologia de floração, descrever a morfologia e biologia floral, verificar os visitantes florais e avaliar o sistema e o sucesso reprodutivo por meio de polinizações manuais. Lepidagathis sessilifolia apresenta inflorescências espiciformes, terminais, com cálice de cor rósea vistosa e corola de coloração branco-rósea. A floração ficou restrita aos meses de março a abril, durante a estação chuvosa. A senescência floral ocorreu após 24 ou 48 horas. A viabilidade dos grãos de pólen foi elevada (92,5%. O único polinizador observado visitando as flores de L. sessilifolia foi a abelha Partamona nhambiquara (Apidae - Meliponini. O sistema reprodutivo misto da espécie é caracterizado pela formação de frutos por meio de agamospermia, autopolinização e polinização cruzada. Esse sistema reprodutivo flexível é vantajoso, pois, garante a manutenção da espécie na área de estudo mesmo na ausência de polinizadores.The genus Lepidagathis has pantropical distribution and about 100 species, 16 occurring in Brazil, mostly in the Midwest and Southeast regions. The research was carried out to evaluate in the understory of a forest remnant in Tangará da Serra County - MT to examine the flowering phenology, describe the floral morphology and biology and verify the floral visitors to evaluate the system and reproductive success through hand pollination tests. Lepidagathis sessilifolia shows spiciform and terminal inflorescence with calyx of pink color and corolla whitish-pink. Flowering was restricted from March to April, during the rainy season. Floral senescence occurred after 24 or 48 hours. The viability of pollen grains was high (92.5%. The effective pollinator of L. sessilifolia was Partamona nhambiquara (Apidae - Meliponini. The mixed mating system of the species is characterized by the formation of fruits by agamospermy, self and cross-pollination, spontaneous self-pollination, agamospermy and outcrossing. This flexible reproductive system is advantageous because it ensures the maintenance of species in the study area even in the absence of pollinators.

  6. A Study on the Joint Reliability Importance with Applications to the Maintenance Policy

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Jung Sik; Kwon, Hong Je; Song, Mi Ja; Kim, Woong Kil; Yoong, Do Hwa [Seoul National Polytechnic University, Seoul (Korea, Republic of); Moon, Sin Myung; Cho, Bong Je; Moon, Jae Phil; Koo, Hoon Young; Lee, Jin Seung [Seoul National University, Seoul (Korea, Republic of)

    1997-09-01

    The objective of this project is to investigate the possibility of applying the Joint Reliability Importance(JRI) of two components to the establishment of system maintenance policy. Components are classified into reliability substitutes and reliability compliments. If the sign of JRI of two components is positive, they are called as reliability compliments. If the sign of JRI of two components is negative, they are called as reliability substitutes. In case of reliability compliments, one component becomes more important as the other one works and in case of reliability substitutes, one component becomes more important as the other one fails. Therefore, when the preventive maintenance is carried out, two components which are reliability substitutes should not be maintained at the same time. Also, when the corrective maintenance is carried out, we not only repair the failed components but pay attention to the functioning components which are reliability substitutes with respect to the failed components. The sign of JRI of any two components in series (parallel) system is positive (negative). Then, what is the sign of any two components in k-out-of-n:G system? This project presents an idea of characterizing the k-out-of-n:G system by calculating the JRI of two components in that system, assuming that reliability of all components are equal. In addition to the JRI of two components, JRI of two gates is introduced in this project. The algorithm to compute the JRI of two gates is presented. Bridge system is considered and the co-relation of two min cut sets is illustrated by using the cut-set representation of bridge system and calculating the JRI of two gates. 28 refs., 20 tabs., 32 figs. (author)

  7. Structure-activity relationships of 3-deoxy androgens as aromatase inhibitors. Synthesis and biochemical studies of 4-substituted 4-ene and 5-ene steroids.

    Science.gov (United States)

    Nagaoka, Masao; Watari, Yoko; Yajima, Hiromi; Tsukioka, Kaoru; Muroi, Yasuyo; Yamada, Keiko; Numazawa, Mitsuteru

    2003-08-01

    As part of our investigation into the structure-activity relationship of a novel class of aromatase inhibitors, two series of 3-deoxy androgens, androst-5-en-17-ones with a non-polar alkoxy (5 and 6), alkyl (20-22), or phenylalkyl (23 and 24) group at C-4beta and 4-acyloxyandrost-4-en-17-ones (29-32, and 34) were synthesized and evaluated. The 4beta-alkyl and 4beta-phenylalkyl compounds were obtained through reaction of 4alpha,5alpha-epoxy steroid (8) with RMgBr (R: alkyl and phenylalkyl) followed by dehydration of the 4beta-substituted 5alpha-hydroxy products (15-19) with SOCl(2) as key reactions. Acylation of 4alpha,5alpha-diol (25) with (RCO)(2)O in pyridine and subsequent dehydration with SOCl(2) gave the 4-acyloxy steroids. All of the steroids studied, except for 4-acetoxy-19-ol (34) that was a non-competitive inhibitor of human placental aromatase, blocked aromatase activity in a competitive manner. 4-Benzoyloxy- and 4-acetoxy steroids (31) and (32) were the most powerful inhibitors of aromatase (K(i)=70 and 60nM, respectively). Elongation of an acetoxy group in a series of 4-acyloxy steroids or a methyl group in a series of 4beta-alkyl steroids decreased affinity for aromatase principally in relation to carbon number of the acyl or alkyl function. The present findings are potentially useful for understanding the spatial and electronic nature of the binding site of aromatase as well as for developing effective aromatase inhibitors.

  8. Demonstration of Laser Plasma X-Ray Source with X-Ray Collimator Final Report CRADA No. TC-1564-99

    Energy Technology Data Exchange (ETDEWEB)

    Lane, S. M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Forber, R. A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-09-28

    This collaborative effort between the University of California, Lawrence Livermore National Laboratory (LLNL) and JMAR Research, Inc. (JRI), was to demonstrate that LLNL x-ray collimators can effectively increase the wafer throughput of JRI's laser based x-ray lithography systems. The technical objectives were expected to be achieved by completion of the following tasks, which are separated into two task lists by funding source. The organization (LLNL or JMAR) having primary responsibility is given parenthetically for each task.

  9. Emotsioonid eesti keele käeväljendites / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene, 1964-

    2010-01-01

    Analüüsitakse eesti keele kõnelejate konventsionaalseid teadmisi ja ettekujutusi suhtlusprotsessist, uurides lähemalt leksikaalseid väljendeid, mille üheks komponendiks on viide käele (või selle osale)

  10. Solvent Effects in Asymmetric Hetero Diels-Alder and Ene Reactions

    DEFF Research Database (Denmark)

    Johannsen, Mogens; Jørgensen, Karl Anker

    1996-01-01

    The use of polar solvents such as nitromethane or 2-nitropropane leads to a significant improvement of the catalytic properties of a cationic copper-Lewis acid in the hetero Diels-Alder reaction of alkyl glyoxylates with dienes; The scope of a newly developed copper(II)-bisoxazoline catalyst...... for the hetero Diels-Alder reaction is demonstrated by the reaction of different dienes with alkyl glyoxylates in nitroalkane solvents with the formation of the hetero Diels-Alder adduct in high enantiomeric excess as the major product. The synthetic application of the reaction is exemplified by an improved...

  11. Jaan Kross : rahvuse rajajoontest / Thomas Salumets ; inglise k. tlk. Ene-Reet Soovik

    Index Scriptorium Estoniae

    Salumets, Thomas, 1956-

    2005-01-01

    Ettekanne pidulikul koosolekul "Jaan Kross 80" Tartu Ülikooli aulas 17. II 2000. Inglise k.: Interlitteraria 2000, nr. 5 ; Journal of Baltic Studies, 2000, vol. 31, nr. 3. Eesti k. varem ilmunud: Võim ja kultuur / koost. Arvo Krikmann, Sirje Olesk. Tartu : Eesti Kirjandusmuuseum, 2003. Orig.: Jaan Kross: Negotiating nation

  12. The role of trust in business relations in Estonia / Urve Venesaar, Ene Kolbre

    Index Scriptorium Estoniae

    Venesaar, Urve, 1944-

    2004-01-01

    Ärisuhete analüüsi tulemustest lähtuvalt järeldavad autorid, et Eesti ettevõtjad ei ole koondanud oma ärisuhted ainult isiklikule, vaid ka kollektiivsele ja institutsionaalsele usaldusele, mida on mõjutanud ettevõtete kohanemise vajadus tänaseks välja kujunenud Eesti ärikeskkonnas. Tabelid

  13. Pilk lõppevasse aastasse / Veljo Kaasik, Ene-Liis Semper

    Index Scriptorium Estoniae

    Kaasik, Veljo, 1938-

    2000-01-01

    2000. a. oli võimalik jälgida eesti arhitektuuri rahvusvahelises taustsüsteemis EXPO 2000-l Hannoveris ning Veneetsia arhitektuuribiennaalil. EKA arhitektuuriosakonna püüdlustest laiendada arhitektuurilist tegutsemispiirkonda. E.-L. Semper osalemisest "Manifestal", R. Kurvitza lahkumisest galeriis "Vaal".

  14. Tulevik lähtub kultuuripärandist / Ene Riet

    Index Scriptorium Estoniae

    Riet, Ene, 1954-

    2009-01-01

    IFLA 75. aastakonverents "Raamatukogud loovad kultuuripärandist lähtuvalt alternatiivset tulevikku" peeti 23.-27. augustini 2009 Milanos. Sektsioonides toimunust, ettekannetest, Itaalia raamatukogundusest

  15. Päevad on laused : [luulekava] / Ene Mihkelson ; koost. Arne Merilai

    Index Scriptorium Estoniae

    Mihkelson, Ene, 1944-2017-

    2005-01-01

    Sisu: "Ühel väga pimedal väga lagedal väljal kus must taevas..." ; "Luuletaja elas pimedas toas ja ootas nägemusi..." ; "Ma lähen ma tulen ma olen ma seisan alati paigal..." ; "Miks meeldib mulle tetraeeder just karjamaal..." ; "Igavene on ilmaköis..." ; "Elu ongi jumalagajätt väljamõeldud..." ; "Kui olin saanud neljaseks Nii väga kiitis..." ; "Meid oli üks tüdruk Me rääkisime..." ; "Olin kaua endaga ma isekeskis õppisin..." ; "Varemed ei põle need vajuvad mulda..." ; "Juustes kasvab valgus..." ; "Küll tahaks vabaneda valeluulest..." ; "Ta armastus on surm..." ; "Minult on küsitud, kas ma saan keerulisemalt ja ma olen öelnud..." ; "Ta haridus oli lünklik, omandatud peamiselt iseõppimise..." ; "Valge kala ujub läbi metsa..." ; "Sinagi kuuled vist kuidas..." ; "Raual on raua kõla..." ; "Need köied ripuvad..." ; "Ärkasin kolmekümne seitsme aastasena..." ; "Üksteise sisse on minek asjadel ja elul..." ; "Mitte metsade vahelt vaid põldude äärest..." ; "Hämarusest tulevad ja hämarusse lähevad näod..." ; "Ta jutustas, mida nägi, ja see oli nii, nagu oleksid kõik..." ; "Mu päevatöö on read mu päevatöö on vari..." ; "Minevik on müüa..." ; "Üks kauge küla tappis ennast ise..." ; "Suur must auk on küla sees..." ; "Rooste on rahulik Rooste..." ; "Mees kes pianisti sõrmeluid ükshaaval murdnud..." ; "Kellele tema oma hinge müüs..." ; "Tuletan sulle meelde et oleme palju..." ; "Sest tema oli barbar mitte päritolu tõttu, vabast tahtest..." ; "Kui veel reagi kirjutad..." ; "Sügavale on taevas mind matnud..." ; "Kes ta siis ikkagi oli: inimene eikuskilt, miks ta ei..." ; "Me läheme ürgsele maale seal pilvede kodu..." ; "Kannan sõelaga aega..." ; "Jumal sina oled näinud mu kujutluste..." ; "Tõstsin kivi mille all elas vähk..." ; "See hingelõpp see võppumine..." ; "Risti alla pandi sinu keha..." ; "Igal ajal ööl on musta värvi..." ; "Vahest elaski kord mees kelle..." ; "Vast ainult üks meil on see päris hull..." ; "Arturi kollased silmad..." ; "Lumi on katnud kinni varemed ja kuusehekk kasvanud..." ; "Kord jäävad ainult jooned ajalukku..." ; "Meie kirjutame luuletusi hõredale õhule..." ; "Ammutamatu on õhtu mil läheme koju..." ; "Väike poiss igavesti narmendavas palitus..." ; "Aadu oli mu klassivend..." ; Kell viis kui pole lund

  16. Tammsaare, Kangro ja Vanapagan / Ilse Lehiste ; inglise k. tlk. Ene-Reet Soovik

    Index Scriptorium Estoniae

    Lehiste, Ilse, 1922-2010

    2000-01-01

    Orig.: Tammsaare, Kangro and the Devil. Varem ilmunud: Baltic Literature and Linguistics. Ohio : Association for the Advancement of Baltic Studies, 1973. A. H. Tammsaare romaanist "Põrgupõhja uus Vanapagan" (1939) ning Bernard Kangro romaanist "Taeva võtmed" (1956)

  17. How newness enters a country : reception of the "postcolonial" in Estonia / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet, 1968-

    2006-01-01

    Postkolonialistliku tõlkekirjanduse retseptsiooni Eestis vaadeldakse kolme romaani põhjal: Arundhati Roy "Väikeste Asjade Jumal" (eesti k. 1997 ja 2004), Salman Rushdie "Mauri viimane ohe" (eesti k. 2001 ja 2008), Ben Okri "Näljutatud tee" (eesti k. 1998)

  18. Mini ja maxi / Ene Läkk ; kommenteerinud Triin Ojari ja Allan Strus

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Eesti väikseimast ja pompoosseimast eramust. Mati Raiemaa 3-liikmelise perekonna 30 m² suurusest elamust Kesk-Kaare tn. Tartus. Hoone juurde kuulub Saaremaa paadimeistrite ehitatud tünnikujuline saun. Tallinnas asuvast advokaat Viktor Kaasiku üle 700 m² suurusest villast. Arhitektuuriajaloolane Triin Ojari ja arhitekt Allan Strus villast

  19. Lean versus Quick Response Manufacturing og andre koncepter - er Lean den eneste ene?

    DEFF Research Database (Denmark)

    Michelsen, Aage U

    2005-01-01

    principper fra andre koncepter? Artiklen er opdelt i fire hovedafsnit. I første afsnit skitseres baggrunden for Lean. I andet afsnit skitseres kort indholdet i Lean. I tredje afsnit skitseres tankegangen bag Quick Response Manufacturing - et begreb, der har mange ligheder med Lean, men som har fokus på......Begrebet Lean har gennem de senere år vundet en enorm udbredelse. Antallet af publikationer om Lean har været eksplosivt stigende, og mange virksomheder har gennemført eller gennemfører Lean-projekter. Er Lean et nyt koncept? Er Lean den eneste løsning? Kan Lean kombineres med tankegange og...... løsning af en anden produktionsopgave. I fjerde afsnit skitseres kort relationerne mellem Lean og to andre begreber, Six Sigma og TPM, der begge har samme mål som Lean, men forskellige udgangspunkter og forskellige indfaldsvinkler....

  20. Kas nii nagu ikka? : Eesti Sisearhitektide Liidu 2010. aasta preemiad / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2011-01-01

    Konkursist "Eesti interjöörid ja mööblidisain 2010". Söögikoha interjööri preemia: kohvik Supelsaksad Pärnus (Ruth ja Anna Huimerind), ühiskondliku interjööri preemia: ADM Interactive'i bürooruumid Tallinnas (Tomomi Hayashi, Ahti Grünberg, Kerli Valk), ajaloolise interjööri preemia: Kihnu muuseum (Malle Jürgenson, Tea Tammelaan, Krista Lepland, Jaak Huimerind, Indrek Laos), näituse- ja installatsiooni kujunduse preemia: rändnäitus "Eesti kirjanik karikatuuris" (Janno Siimar, Kaarel Vahtramäe, Mart Lankots, Liina Jakobson), tudengipreemia - Aet Tera. 24 nominenti loetletud

  1. Learning Organizations. Studiu exploratoriu asupra Consiliilor Judeţene din România

    Directory of Open Access Journals (Sweden)

    Diana GHIURA

    2012-12-01

    Full Text Available This article is the result of an ample study centered on the concept of learning organizations, more precisely on the degree in which Romanian County Councils are learning organizations. In order to analyze this, a research instrument has been sent to every County Council. This tool has been developed by three Harvard professors: David A. Garvin, Amy C. Edmondson and Francesca Gino who also published, in 2008, an article in Harvard Business Review ‘Is Yours A Learning Organization?’. Their article is fundamental for this study. Approximately 26 out of 41 County Councils participated to the study and the findings are summarized in this article. The results were really interesting and according to them, Romanian County Councils are learning organizations only in terms of leadership that encourages learning. Regarding the other two blocks – learning environment and learning processes, the findings revealed that the County Councils act like learning organizations in a very small degree. As a consequence, the organizations that participated to the study still have many things to improve in order to become learning organizations.

  2. Vaesus ja ebavõrdsus = Poverty and inequality / Mari Kreitzberg, Ene-Margit Tiit

    Index Scriptorium Estoniae

    Kreitzberg, Mari

    2004-01-01

    Vaesuse ja ühiskonna sotsiaalsest sidususest, vaesuse määratlemisest, subjektiivsest vaesusest, sissetuleku- ja kuluvaesusest, vaesuspiirist, absoluutsest ning suhtelisest vaesusest. Diagrammid. Tabelid. Graafikud

  3. Vene kinopravdast sai prantsuse cinema-verite / Ronald Bergan ; tõlk. Ene Jürna

    Index Scriptorium Estoniae

    Bergan, Ronald

    2004-01-01

    FIPRESCI asepresident meenutab 18. veebruaril 2004.a. surnud prantsuse dokumentalistika suurkuju Jean Rouchi (sünd. 31.05.1917). Lisatud Jaan Ruusi kommentaar Rouchi sidemetest Eesti kineastide Mark Soosaare ja Vladimir Karassev-Orgussaarega

  4. Me suudame ajaga kaasas käia / interv. Ene Riet

    Index Scriptorium Estoniae

    2003-01-01

    Eesti raamatukoguhoidjate VIII kongressi (9.-10. juuni 2002) delegaatitelt küsiti arvamust Eesti raamatukogunduse kohta, vastasid: Kalli Kuhi, Sirje Okapuu, Toomas Liivamägi, Sirje Lauring-Vaska, Helve Sreiberg, Irina Kruusla, Ädu Neemre, Tiit Margna, Valentina Brovina, Asko Tamme, Meeli Veskus

  5. Microcellular open porous polyester membranes from thiol-ene polymerisations of high internal phase emulsions

    Czech Academy of Sciences Publication Activity Database

    Sušec, M.; Paljevac, M.; Kotek, Jiří; Krajnc, P.

    2016-01-01

    Roč. 19, č. 6 (2016), s. 577-583 ISSN 1385-772X R&D Projects: GA MŠk(CZ) LO1507 Institutional support: RVO:61389013 Keywords : polymer membranes * mechanical properties * polyHIPE Subject RIV: CD - Macromolecular Chemistry Impact factor: 1.139, year: 2016

  6. 78 FR 717 - ENE (Environment Northeast); Greater Boston Real Estate Board; National Consumer Law Center...

    Science.gov (United States)

    2013-01-04

    ... Boston Real Estate Board, National Consumer Law Center, and NEPOOL Industrial Customer Coalition... (Environment Northeast); Greater Boston Real Estate Board; National Consumer Law Center; NEPOOL Industrial Customer Coalition; v. Bangor Hydro-Electric Company; Central Maine Power Company; New England Power...

  7. Juhatus ja raamatupidaja jagavad vastutust. [1.-2. osa] / Ene Ahas, Alo Pormeister

    Index Scriptorium Estoniae

    Ahas, Ene, 1973-

    2017-01-01

    Varalise vastutuse kokkuleppest, raamatupidaja ja juhatuse vastutusest. Tööõiguslikust vastutusest töölepingu seaduse alusel ja kahju hüvitamisest tööandjale. Lepingulisest ja lepinguvälisest vastutusest. Sisaldab asjakohast kohtupraktikat

  8. Glosario EN-ES de ensayos clínicos (2.° parte: N-Z)

    OpenAIRE

    María Verónica Saladrigas; Fernando A. Navarro; Laura Munoa; Pablo Mugüerza; Álvaro Villegas

    2008-01-01

    La investigación clínica, y dentro de ella la basada en ensayos clínicos con medicamentos, genera un volumen ingente de documentación escrita que es preciso traducir del inglés al español. El presente glosario está pensado como ayuda práctica al traductor especializado que se enfrenta a esta compleja tarea. Se han seleccionado cerca de 1400 conceptos básicos del ámbito de los ensayos clínicos y otras disciplinas afines y se han organizado buscando la máxima claridad expositiva. Para cada ent...

  9. Glosario EN-ES de ensayos clínicos (1.° parte: A-M)

    OpenAIRE

    María Verónica Saladrigas; Fernando A. Navarro; Laura Munoa; Pablo Mugüerza; Álvaro Villegas

    2008-01-01

    La investigación clínica, y dentro de ella la basada en ensayos clínicos con medicamentos, genera un volumen ingente de documentación escrita que es preciso traducir del inglés al español. El presente glosario está pensado como ayuda práctica al traductor especializado que se enfrenta a esta compleja tarea. Se han seleccionado cerca de 1400 conceptos básicos del ámbito de los ensayos clínicos y otras disciplinas afines y se han organizado buscando la máxima claridad expositiva. Para cada ent...

  10. Synthesis and In Vitro Antiproliferative Activity of Novel Androst-5-ene Triazolyl and Tetrazolyl Derivatives

    Directory of Open Access Journals (Sweden)

    János Wölfling

    2011-06-01

    Full Text Available A straightforward and reliable method for the regioselective synthesis of steroidal 1,4-disubstituted triazoles and 1,5-disubstituted tetrazoles via copper(I-catalyzed cycloadditions is reported. Heterocycle moieties were efficiently introduced onto the starting azide compound 3β-acetoxy-16β-azidomethylandrost-5-en-17β-ol through use of the “click” chemistry approach. The antiproliferative activities of the newly-synthesized triazoles were determined in vitro on three human gynecological cell lines (HeLa, MCF7 and A2780 using the microculture tetrazolium assay.

  11. Developing interviewer proficiency : a self-perception survey / Riin Kont-Kontson, Ene Alas, Suliko Liiv

    Index Scriptorium Estoniae

    Kont-Kontson, Riin

    2013-01-01

    Inglise keele õpetajate hulgas läbi viidud uurimusest, mis näitas, et intervjueerijate arusaam oma kutsestandardist varieerub märkimisväärselt. Probleemide lahendamiseks esitatakse mitmeid koolitusstrateegiaid

  12. Photolithographic fabrication of solid–liquid core waveguides by thiol-ene chemistry

    DEFF Research Database (Denmark)

    Sagar, Kaushal Shashikant; Gopalakrishnan, Nimi; Christiansen, Mads Brøkner

    2011-01-01

    . The generated refractive index contrast between the patterned water-filled volume and the surrounding empty hydrophobic porous polymer allows for light confinement within the water-filled volume—the solid–liquid core. The presented fabrication process is simple and fast. It allows a high degree of flexibility...... on the type and grade of surface chemistry imparted to the large nanoporous area depending upon the application. The fabrication does not need demanding chemical reaction conditions. Thus, it can be readily used on a standard silicon lithography bench. The propagation loss values reported in this work...

  13. Asutamisvabadus Euroopa Ühenduse õiguses : kohaldatavus ladina notariaadile / Ene Andresen

    Index Scriptorium Estoniae

    Andresen, Ene, 1977-

    1999-01-01

    Euroopa Ühenduse asutamislepingu kohaldatavusest notariametile, "avaliku võimu teostamise" mõistest ning vastavatest Euroopa Kohtu lahenditest, Eesti notariaaltoimingute vastavusest Euroopa Ühenduse asutamislepingule ning üksikute tegevuste eraldatavuse probleemist

  14. Riigipeade kokad - Chefs des Chefs / Sirkka Ruottinen, Indrek Kivisalu ; interv. Ene Ojaveski

    Index Scriptorium Estoniae

    Ruottinen, Sirkka

    2006-01-01

    Soome presidendi Tarja Haloneni ja Eesti presidendi Arnold Rüütli peakokad räägivad oma karjäärist presidendi peakoka ametini, kirjeldavad tavalist tööpäeva ja töökeskkonda presidendi köögis, iseloomustavad Soome ja Eesti toidukultuuri ning meenutavad huvitavaid seiku oma ametiajast. Vt. samas: Sirkka Ruottinen vastab küsimustele, mis puudutavad Riigipeade Peakokkade Klubi (Club des Chefs des Chefs) tegevust

  15. Interviewer behaviour during oral proficiency interviews : a gender perspective / Edith Reemann, Ene Alas, Suliko Liiv

    Index Scriptorium Estoniae

    Reemann, Edith

    2013-01-01

    Analüüsitakse intervjueerija käitumise soolisi iseärasusi inglise keele riigieksami suulise keelepädevustesti läbiviimisel, kas on olemas ühele või teisele sugupoolele omaseid käitumismalle ning kas need võiksid mõjutada intervjueeritavat oma oskuste demonstreerimisel

  16. Amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid

    Czech Academy of Sciences Publication Activity Database

    Özdemir, Zülal; Bildziukevich, Uladzimir; Šaman, David; Havlíček, Libor; Rárová, L.; Navrátilová, L.; Wimmer, Zdeněk

    2017-01-01

    Roč. 128, DEC (2017), s. 58-67 ISSN 0039-128X R&D Projects: GA MŠk LD15012 Institutional support: RVO:61389030 ; RVO:61388963 Keywords : Amphiphile * Antimicrobial activity * Cytotoxicity * Diamine * Polyamine * Steroid Subject RIV: CC - Organic Chemistry; CC - Organic Chemistry (UOCHB-X) OBOR OECD: Organic chemistry Impact factor: 2.282, year: 2016

  17. Muudatused sisemajanduse koguprodukti arvestustes = Changes in the methodology of macroeconomic statistics / Ene Kaldma

    Index Scriptorium Estoniae

    Kaldma, Ene

    2004-01-01

    2004. aastal tehtud muudatused makromajandusstatistika metoodikas tõid kaasa 1993.-2003. aasta sisemajanduse koguprodukti (SKP) ja selle komponentide suuruse korrigeerimise. Tabel: Sisemajanduse koguprodukt turuhindades kvartalite kaupa enne ja pärast metoodika muutumist, 1993-2003

  18. Otsusta Eesti Tulevik / Arnold Rüütel, Ene Ergma, Juhan Parts

    Index Scriptorium Estoniae

    Rüütel, Arnold

    2003-01-01

    Ilmunud ka Valgamaalane (2003/Jun/28) lk. 2 ; Sakala (2003/Jun/27) lk. 2 ; Koit (2003/Jun/26) lk. 7 ; Maaleht (2003/Jun/26) lk. 4 ; Põhjarannik (2003/Jun/26) lk. 2 ; Severnoje Poberezhje (2003/Jun/26) lk. 2 ; Vooremaa (2003/Jun/26) lk. 1 ; Vaba Eesti Sõna (2003/Jul/2) lk. 3 ; Tribüün : Euroopa Liidu rahvahääletuse eri (2003/Aug/15) lk. 3. Vabariigi Presidendi, Riigikogu esimehe ja peaministri ühisavalduse tekst

  19. Whats 'App-ening': the help of new technologies in nutrition in digestive diseases.

    Science.gov (United States)

    Ankersen, Dorit V; Weimers, Petra; Burisch, Johan

    2017-09-01

    The aim of this study is to review the basic concepts of electronic health (eHealth), with a focus on its nutritional applications and its usefulness for digestive diseases. eHealth applications for the treatment and monitoring of digestive disease are growing in number. ehealth helps patients in coping with their disease by promoting self-management, which increases adherence to medical treatment and diets, and leads to an improved quality of life. For irritable bowel syndrome (IBS), there are multiple applications that provide dietary advice, for example, a low FODMAP (Fermentable Oligo, Mono, Disaccharides And Polyols) diet. However, many applications lack a symptom scoring function and do not include a module for assisting the essential reintroduction of high FODMAP foods. In general, there are very few applications that enable direct patient communication with healthcare professionals. A more holistic approach that educates patients and enables them to communicate directly with eCare provider through a web application is one of the functions most requested by patients. eHealth solutions for digestive diseases have a supportive function and a positive impact on patients. However, there is a need to increase patient education and further develop the possibility for care team-patient communication within eHealth solutions.

  20. Lean versus Quick Response Manufacturing og andre koncepter - er Lean den eneste ene?

    DEFF Research Database (Denmark)

    Michelsen, Aage U

    2005-01-01

    Begrebet Lean har gennem de senere år vundet en enorm udbredelse. Antallet af publikationer om Lean har været eksplosivt stigende, og mange virksomheder har gennemført eller gennemfører Lean-projekter. Er Lean et nyt koncept? Er Lean den eneste løsning? Kan Lean kombineres med tankegange og princ...... løsning af en anden produktionsopgave. I fjerde afsnit skitseres kort relationerne mellem Lean og to andre begreber, Six Sigma og TPM, der begge har samme mål som Lean, men forskellige udgangspunkter og forskellige indfaldsvinkler....

  1. "Juu Jääb" 2009 džässisaarel / Ene Kallas

    Index Scriptorium Estoniae

    Kallas, Ene

    2009-01-01

    Kolmeteistkümnenda tulevikumuusika festivali "Juu Jääb" (peakorraldaja Villu Veski) üritustest Muhu saarel, Vormsil ja Kuressaares. Muhus Nautse külas Mihkli talus toimunud kontsertidest, kus esinesid saksa lauljanna Pascal von Wroblewsky, USA ansambel Napoleon Maddox Quartet, saksofonist Lembit Saarsalu koos Trio X-ga, Ivo Linna koos Olav Ehala, Toivo Undi ja Kaspar Kallustega

  2. Austraalia ilusaim rannikutee sõjaohvrite mälestuseks / Eneli Ivask

    Index Scriptorium Estoniae

    Ivask, Eneli

    2006-01-01

    Vt. ka Delovõje Vedomosti : Vkuss Zhizni 13. sept., lk. 4-5. Austraalia lõunarannikul, mitte kaugel Melbourneist on maailma kauneimaks peetav 400 km pikkune hingematvalt lummavate ja erinäoliste vaadetega rannikutee - Great Ocean Road

  3. Roll-to-plate fabrication of microfluidic chips with thiol-ene resins

    DEFF Research Database (Denmark)

    Senkbeil, Silja; Yde, Leif; Lindvold, Lars R.

    2015-01-01

    This paper demonstrates the fabrication and performance of a capillary electrophoresis (CE) chip with a UV-assisted roll-to-plate fabrication mechanism. Patterning and lamination of the chip can be performed with fabrication speeds of up to 19 m/min (ca. 20 chips/min), offering a rapid and simple...... production method for medium to high volume chip fabrication. The performance of the CE chip is demonstrated with an electrophoretic separation of two different fluorescent dyes.......This paper demonstrates the fabrication and performance of a capillary electrophoresis (CE) chip with a UV-assisted roll-to-plate fabrication mechanism. Patterning and lamination of the chip can be performed with fabrication speeds of up to 19 m/min (ca. 20 chips/min), offering a rapid and simple...

  4. Kelle emotsioonile anda teksti ette lugedes hääl? Vaatlus mitmest perspektiivist / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene, 1964-

    2014-01-01

    Püütakse esile tuua, milliste inimloomusest tulenevate tõsiasjadega peab arvestama, kui hakata sünteeskõnele emotsioone matkivat prosoodiat lisama. Koondatud on lähenemised erinevatest teadusharudest

  5. Programmable Liquid Crystal Elastomers Prepared by Thiol-Ene Photopolymerization (Postprint)

    Science.gov (United States)

    2015-08-17

    hierarchical) orientation of liquid crystal polymers can be used to generate bending and torsional deflections.20 Hierarchical variation is...mercaptopropionate), which has a molecular weight per thiol of 122 g/mol. These formulations did not exhibit the required combination of a readily alignable nematic...nematic director to the long axis of the sample by 30° (Figure S1) produces torsional deformations. On heating, the sample morphs from flat to a twisted

  6. Kuressaare kultuurikeskus täitus eile leivalõhnaga / Ene Kallas

    Index Scriptorium Estoniae

    Kallas, Ene

    2009-01-01

    Kuressaare kultuurikeskuse näituse "Leib on talu peremees" avamisel viisid Eesti Põllumajandusmuuseumi töötajad läbi leivaprogrammi. Näituse koostas Mare Viiralt, kunstnikutöö tegi Maarika Tang

  7. Tööjuhendid algklassi tööõpetuse tundides / Ene Lind

    Index Scriptorium Estoniae

    Lind, Ene

    2001-01-01

    Tekstiga tööst tööõpetuse tunnis, kirjalikust ja suulisest juhendamisest. Tallinna Pedagoogikaülikooli üliõpilaste poolt läbi viidud küsitlusest, milles osalesid 22 klassiõpetajat Tallinnast ja 15 mujalt vabariigist. Kõik pedagoogid andsid oma klassis ka tööõpetuse või käsitöö tunde. Küsitlusega selgitati, milline on tööjuhendite abil korraldatava iseseisva individuaalse töö osatähtsus noorema kooliastme tööõpetuse ja eri õppeainete tundides

  8. Measurements of low-energy e+--Ne and e+-Ar total scattering cross sections

    International Nuclear Information System (INIS)

    Charlton, M.; Laricchia, G.; Griffith, T.C.; Wright, G.L.; Heyland, G.R.

    1984-01-01

    Measurements of positron and electron-Ne total scattering cross sections are reported in the energy range 2-50 eV. e + -Ar total cross sections are presented in the energy range 2-20 eV. In both the e + -Ne and e + -Ar cases marked discrepancies are found with other recent measurements and these are discussed along with possible systematic errors which may affect the data. The e - -Ne measurements are found to be in excellent agreement with recent experiments. (author)

  9. Kütiorus on kõrvuti pronksiaeg ja postmodernism / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Külaskäik Kütioru Avatud Ateljeesse. Peeter ja Leelo Lauritsa tegemistest ja plaanidest seoses ateljeega. Valminud on ateljeemaja ümberehitamise makett. Ehitusmaterjaliks savi. Nõustavad Tartu ökoinsenerid. Sügisel 1999 viibisid Kütiorus Vogue'i ajakirjanikud ja Londoni fotograaf Zanna, et teha Casa Vogue'ile illustreeritud Kütioru Avatud Ateljeed tutvustav lugu. 5 värvilist illustratsiooni

  10. Eesti keele sõnavara afektikalduvus ja mis sellega peale hakata / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene, 1964-

    2012-01-01

    Praktilisest vajadusest väljakasvanud probleemist muuta eestikeelne sünteeskõne loomulikumaks ja emotsionaalselt usutavamaks. Artiklis keskendutakse leksikaalsele tasandile, arutletakse selle üle, millised sõnaklassid on enim emotsioonidega seotud

  11. Tootedisaineri töö peenmehaanika ja olemise jaatus / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2011-01-01

    Tootjate ja riskikapitalistide huvist tootedisaineri teenuse vastu. Eesti disainibüroodest MaDis-Stuudio (Matti Õunapuu), Ten Twelve (asutaja: Jukka Halttunen), Keha3 (Margus Triibmann, Tarmo Luisk, Pavel Sidorenko, juht: Ville Jehe) ja Iseasi (Martin Pärn, Sven Sõrmus, Edina Dufala-Pärn, Pent Talvet, Kaspar Torn), pakutavatest teenustest ja töödest

  12. Roll-to-plate fabrication of microfluidic devices with rheology-modified thiol-ene resins

    DEFF Research Database (Denmark)

    Senkbeil, Silja; Aho, Johanna; Yde, Leif

    2016-01-01

    of 2:1 and a maximal channel depth of 90 μm as well as the sealing of the finished devices with patterning and sealing speeds of up to 19 m min-1. By adding fumed silica nanoparticles to the uncured resins, it was possible to alter the rheological behavior of the resin system to fabricate shallow...

  13. Takova zhizn, ili nash tshelovek v Pompidu / Ene Rämmeld ; interv. Boris Tuch

    Index Scriptorium Estoniae

    Rämmeld, Ene, 1947-

    2004-01-01

    Pariisis elav näitlejanna esitles oma autobiograafilist raamatut "C'est la vie. Elu on selline", milles juttu kolmest kunstnikust : L. Laiusest, E. Hermakülast ja V.G. Karassev-Orgussaarest - kuidas nad kõik mõjutasid näitlejanna arengut. Ka oma elust ja elufilosoofiast praegu

  14. Lendab nagu kotkas üle maailmas kogutud tarkuse / Richard Aroksaar ; intervjueerinud Ene Riet

    Index Scriptorium Estoniae

    Aroksaar, Richard

    2014-01-01

    Intervjuu eestlase Richard Aroksaarega, kes õppinud psühholoogiat ja raamatukogundust, töötab USA Rahvusparkide Ühenduse raamatukogus (National Park Service Library, NPS) süsteemi raamatukoguhoidja ja administraatorina

  15. Emotsioonisõnad töises keskkonnas - millest kõnelevad loetelukatsete tulemused? / Ene Vainik

    Index Scriptorium Estoniae

    Vainik, Ene

    2007-01-01

    Emotsioonisõnade esiletulekut tööl ja mujal võrreldakse 2001. aastal läbi viidud loetelukatsetes, tulemuste semantilise analüüsi põhjal tehakse järeldused koha mõju üle emotsioonisõnavarale

  16. Terves kehas terve vaim - a sound mind in a sound body / Ene Kelder

    Index Scriptorium Estoniae

    Kelder, Ene

    2012-01-01

    Pühajärve Haridusseltsi täiskasvanutele suunatud projektist, mille eesmärgiks oli suurendada täiskasvanud õppijate hulka piirkonnas ning praktiseerida aktiivset eluhoiakut ja tervislikke eluviise

  17. Punane moon või kaine mõistus / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2001-01-01

    Nukuteatri uue hoone sisekujunduse võistluse I ja II koha töödest. I koha töö autorid Raivo Kotov ja Andrus Kõresaar, II koha töö autorid Ülar Mark, Liina Link, stilist Ain Nurmela ja arvutigraafik Tanel Viks büroost Mark & Tamm Arhitektid

  18. Intramolecular butenolide allene photocycloadditions and ensuing retro-ene reactions of some photoadducts

    NARCIS (Netherlands)

    Lutteke, G.; Kleinnijenhuis, R.A.; Jacobs, I.; Wrigstedt, P.J.; Correia, A.C.A.; Nieuwenhuizen, R.; Hue, B.T.B.; Goubitz, K.; Peschar, R.; van Maarseveen, J.H.; Hiemstra, H.

    2011-01-01

    This report describes intramolecular [2+2] photocycloadditions of several butenolides with an allenylmethyl substituent at the 5-position. These photosubstrates were prepared from 2-(silyloxy)furans through silver-mediated reactions with allenylmethyl bromides. Two cases were studied where the

  19. Prügilill, vana hõng ja minimalism / Ene Läkk

    Index Scriptorium Estoniae

    Läkk, Ene, 1957-

    2000-01-01

    Kahest äärmusest praeguses aiakujunduses: minimalismist ja vanahõngulisest, hästi organiseeritud segadusest. Erinevatest materjalidest terrassist, "woodland'ist", moesolevatest prügitaimedest. Trendinäiteks Saksa saatkonna haljasalast Tallinnas (arhitekt R. Herms, teostus Ü. ja U. Grishakov). Soovitusi maastikuarhitekt Ü. Grishakovilt

  20. Tre tilfaelde af visceral leishmaniasis: det ene hos en HIV-positiv mand

    DEFF Research Database (Denmark)

    Balslev, U; Jonsbo, F; Junge, Jette

    1991-01-01

    Three cases of visceral leishmaniasis (kala-azar) are presented. One of these was in a 43-year-old patient with AIDS who was infected in Southern Spain. Another was in a man aged 25 years infected in West Africa. These cases are the first two adults to be reported in Denmark. The third case...

  1. Interview; kunst of kliederen; “De ene graffiti is de andere niet”

    NARCIS (Netherlands)

    Keus, R; Vanderveen, G.N.G.

    2010-01-01

    De aanpak van graffiti staat bij veel gemeenten hoog op de agenda. Het tegengaan van overlast en verloedering is hierbij meestal de belangrijkste reden. Maar om een aanpak echt te laten slagen, moet er volgens onderzoekster Gabry Vanderveen eerst goed worden nagegaan welke vormen van graffiti voor

  2. Courants du Monde'i programmi toel Prantsusmaal / Asko Tamme ; intervjueerinud Ene Riet

    Index Scriptorium Estoniae

    Tamme, Asko

    2010-01-01

    Intervjuu Tartu Linnaraamatukogu direktori Asko Tammega, kes käis tutvumas Prantsusmaa raamatukogudega, sh Pompidou keskuse raamatukoguga, Rennes'i keskraamatukoguga ning Raamatu ja Lugemise Bretagne'i keskusega (Livre et Lecture en Bretagne)

  3. Pismo nepoznate žene i melankolija filozofije: Cavell, Austin, Derrida

    OpenAIRE

    Jukić, Tatjana

    2010-01-01

    My text analyzes the agency of melancholia and melodrama in the philosophy of Stanley Cavell, where they labor as a sinthome of what in philosophy is memory. This analysis hinges on a close reading of Stefan Zweig’s Letter from an Unknown Woman as a point of access to articulating these concerns, as Cavell’s own writing on the subject (in Contesting Tears) hinges on a close reading of Max Ophüls’s film based on Zweig’s novella, but only after Cavell has explicitly excluded Zwei...

  4. Õpetaja haridus, kooliharidus ja ühiskond / Ene-Silvia Sarv

    Index Scriptorium Estoniae

    Sarv, Ene-Silvia, 1945-

    1999-01-01

    Rahvusvahelise Haridusentsüklopeedia tekstist ja Eesti õpetajakoolituse uuendamise kavadest inspireeritud mõtisklus. Teoreetilised teadmised, võimed, eeldused, mida peetakse õpetajale vajalikuks, on seotud haridusele omastatavate eesmärkidega

  5. Dollar$ & $en$e. Part IV: Measuring the value of people, structural, and customer capital.

    Science.gov (United States)

    Wilkinson, I

    2001-01-01

    In Part I of this series, I introduced the concept of memes (1). Memes are ideas or concepts, the information world equivalent of genes. The goal of this series of articles is to infect you with my memes, so that you will assimilate, translate, and express them. We discovered that no matter what our area of expertise or "-ology," we all are in the information business. Our goal is to be in the wisdom business. We saw that when we convert raw data into wisdom we are moving along a value chain. Each step in the chain adds a different amount of value to the final product: timely, relevant, accurate, and precise knowledge which can then be applied to create the ultimate product in the value chain: wisdom. In Part II of this series, I infected you with a set of memes for measuring the cost of adding value (2). In Part III of this series, I infected you with a new set of memes for measuring the added value of knowledge, i.e., intellectual capital (3). In Part IV of this series, I will infect you with memes for measuring the value of people, structural, and customer capital.

  6. Collective memory and the politics of experience in Estonian post-Soviet life stories / Ene Kõresaar

    Index Scriptorium Estoniae

    Kõresaar, Ene, 1971-

    2005-01-01

    Elulugude põimumine kultuuritraditsioonide ja suulise traditsiooniga ning nende jutustamine kui poliitilise ajaloo väljendusvorm. Kollektiivse mälu ja poliitika vahelistest seostest kahe Eesti Kultuuriloolisele Arhiivile saadetud Eesti nõukogude aega kajastava eluloo alusel

  7. Diallyl 5-[(4-hexyl-oxyphen-yl)imino-meth-yl]-m-phenyl-ene dicarbonate.

    Science.gov (United States)

    Herrera-González, Ana María; López-Velázquez, Delia; Bernès, Sylvain

    2009-10-23

    The title mol-ecule, C(27)H(31)NO(7), an imine derivative bearing both carbonate and allyl functionalities, was synthesized in the hope of obtaining a mesogenic polymerizable material. The allyl-carbonate arms are fully disordered over two sets of sites, reflecting a large degree of rotational freedom about σ bonds [occupancies: 0.665 (9)/0.335 (9) for one substituent, 0.564 (9)/0.436 (9) for the other]. In contrast, the hexyl chain is ordered, and presents the common all-trans extended conformation. The benzene rings connected via the imine group make a dihedral angle of 9.64 (11)°. In the crystal, the Y-shaped mol-ecules are weakly associated into centrosymmetric dimers through pairs of C-H⋯O(hex-yl) contacts. The resulting layers of dimers, approximately parallel to (25), are closely packed in the crystal, allowing π⋯π inter-actions between benzene rings of neighboring layers: the separation between the centroid of the benzene ring substituted by allyl-carbonate and the centroid of the benzene ring bearing the hex-yloxy group in the adjacent layer is 3.895 (1) Å.

  8. Tre tilfaelde af visceral leishmaniasis: det ene hos en HIV-positiv mand

    DEFF Research Database (Denmark)

    Balslev, U; Jonsbo, F; Junge, Jette

    1991-01-01

    Three cases of visceral leishmaniasis (kala-azar) are presented. One of these was in a 43-year-old patient with AIDS who was infected in Southern Spain. Another was in a man aged 25 years infected in West Africa. These cases are the first two adults to be reported in Denmark. The third case was a...

  9. Eesti teater esineb Transeuropa festivalil / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2003-01-01

    12. juunil algab Saksamaal Hildesheimis festival Transeuropa 2003, kus esineb Von Krahli Teater lavastusega "Pirates", K. Essenson tantsib oma sooloetendust "So far, so good" ja kunstikriitik ja -kuraator A.Härm korraldab performance'i "Be drunk, be very, very drunk"

  10. "Continental Breakfast" Tallinnas / Anders Härm

    Index Scriptorium Estoniae

    Härm, Anders, 1977-

    2005-01-01

    2.-24. XI Nu Performance Festival Kanuti gildi saalis ja Tallinna Kunstihoones. Osalejatest. Eestit esindab Katrin Essenson. Kunstihoones toimub satelliitüritusena näitus "Elavad skulptuurid", Linnagaleriis Liina Siibi näitus briti kirjanikust Christopher Marlowe'st

  11. Eesti koreograafid Euroopa lavadel

    Index Scriptorium Estoniae

    2004-01-01

    ZUGA ühendatud tantsijad on Zagrebi sümpoosion-festivalil "Group Dynamics", K. Essenson näitab mai keskel Berliini Tanzfabrikis oma soolotööd "So far So Good", R. Keerd on kutsutud oma tööga "Mobile home" Kopenhaageni Kanonhallenisse, et avada Junge Hunde nimeline festival

  12. 1 = 3 õige või vale / Tiia-Triin Truusa

    Index Scriptorium Estoniae

    Truusa, Tiia-Triin

    2001-01-01

    1. märtsil 2001 esietendus Tartu Teatrilaboris Zuga ja teatrilabori ühisprojekt tantsuetendus "1=3 õige või vale". Etenduse lavastaja on Tallinna Pedagoogikaülikooli kultuuriteaduskonna koreograafia eriala lõpetaja Jarmo Karing. Tantsivad TPÜ koreograafia eriala üliõpilased Annika Üprus, Tiina Mölder, Katrin Essenson ja Taavet Jansen

  13. Case note: Gerechtshof 's-Hertogenbosch (ABP partnerpensioen ene partner wordt verminderd met aan andere partner toekomend ABP bijzonder partnerpensioen)

    NARCIS (Netherlands)

    Reinhartz, B.E.

    2009-01-01

    De man is gehuwd geweest met mevrouw X tussen 1962 en 1976. Tussentijds heeft de man van 1986 tot 1990 samengewoond met mevrouw Z. In 1988 is er een samenlevingsovereenkomst gesloten tussen de man en vrouw Z. Tussen 1991 en 1995 hebben de man en mevrouw Z weer samengewoond. In 1994 heeft de man het

  14. Žene u slikarstvu impresionizma na prijelazu stoljeća - primjer Slave Raškaj

    OpenAIRE

    Mačečević, Iva

    2016-01-01

    U radu se predstavlja kratak pregled ženskog položaja u povijesti umjetnosti te se izdvaja pozicija žena i ženskog slikarstva na prijelazu stoljeća. Ističu se četiri impresionistice, njihov život i kako je to utjecalo na njihov opus. Izdvojeni su pojedini radovi u opusima Berthe Morisot, Mary Cassatt, Eve Gonzalès i Marie Bracquemond koji daju opći pregled o njihovoj umjetnosti u okviru impresionizma. Veći dio rada je posvećen životu i opusu Slave Raškaj. U njemu su izdvojena djela koja su pr...

  15. Eesti kooliõpilaste väärtushinnanguist ja huvialadest / Ingrid Rüütel, Ene-Margit Tiit

    Index Scriptorium Estoniae

    Rüütel, Ingrid, 1935-

    2005-01-01

    Artiklis analüüsitakse 2004. a. Eesti koolides läbi viidud ankeetküsitlusi teemal "Kooliõpilaste väärtushinnangud ja huvialad". Küsitleti 12-19-aastasi eestikeelsete koolide õpilasi kogu Eestist. Kokku vastas küsitlusele 345 õpilast

  16. Ettevõtte strateegia ja kinnisvara väärtus / Veronika Ilsjan, Ene Kolbre, Signe Liiv

    Index Scriptorium Estoniae

    Ilsjan, Veronika

    2003-01-01

    Ettevõtte strateegia ja kinnisvarastrateegia ühendamine on kahesuunaline protsess - ettevõtte strateegia peab sisaldama kinnisvaraga arvestamist ja kinnisvara juhtimine lähtuma ettevõtte strateegiast. Tabel. Joonis

  17. Convenient Preparation of Bactericidal Hydrogels by Covalent Attachment of Stabilized Antimicrobial Peptides Using Thiol-ene Click Chemistry

    NARCIS (Netherlands)

    Cleophas, Rik T. C.; Riool, Martijn; van Ufford, H. C. Quarles; Zaat, Sebastian A. J.; Kruijtzer, John A. W.; Liskamp, Rob M. J.

    2014-01-01

    This report describes the design and synthesis of a bactericidal poly(ethylene glycol)-based (PEG) hydrogel coating with covalently attached antimicrobial peptides (AMP) stabilized against proteolytic degradation. As such, mimics of the highly active AMP HHC10 (H-KRWWKWIRW-NH2) were designed for

  18. "WhatsApp"ening in orthopedic care: a concise report from a 300-bedded tertiary care teaching center.

    Science.gov (United States)

    Khanna, Vishesh; Sambandam, Senthil N; Gul, Arif; Mounasamy, Varatharaj

    2015-07-01

    Smartphones have emerged as essential tools providing assistance in patient care, monitoring, rehabilitation, communication, diagnosis, teaching, research and reference. Among innumerable communication apps, WhatsApp has been widely popular and cost effective. The aim of our study was to report the impact of introduction of a smartphone app "WhatsApp" as an intradepartmental communication tool on (1) awareness of patient-related information, (2) efficiency of the handover process and (3) duration of traditional morning handovers among orthopedic residents in a 300-bedded tertiary care teaching center. Written handovers and paging used for communication at our center led to occasional inefficiencies among residents. Widespread use, low cost, availability and double password protection (phone lock and WhatsApp lock) made WhatsApp's group conversation feature an ideal tool for intradepartmental patient-related communication. Twenty-five consecutive admissions before and after WhatsApp (BW, AW) were included in the study. Eight orthopedic residents attempted fifty randomly arranged questions based on the twenty-five patients in each study period. A null hypothesis that introduction of WhatsApp group would neither increase the awareness of patient-related information nor improve the efficiency of the handovers among residents was assumed. A significant improvement observed in scores obtained by residents in the AW group led to rejection of the null hypothesis. The residents also reported swifter and efficient handovers after the introduction of WhatsApp. Our results indicate that the introduction of a smartphone app "WhatsApp" as an intradepartmental communication tool can bring about an improvement in patient-related awareness, communication and handovers among orthopedic residents.

  19. Den enes död, den andres bröd : En fallstudie i Fonus kriskommunikation

    OpenAIRE

    Orest Flavet, Sebastian

    2014-01-01

    Denna studie undersöker hur begravningsbyrån Fonus valde att bemöta en kritisk artikel, publicerad i Aftonbladet, med ett pressmeddelande som lades upp på den egna hemsidan. Uppsatsen undersöker först vilka retoriska verktyg som har använts i skapandet av detta meddelande, och sett från Benoits teori om Image Repair, vilka strategier som använts och hur användningen av dessa har sett ut. Därefter söker studien att praktiskt undersöka detta budskap genom att låta en utvald grupp respondenter t...

  20. Poly[[μ-aqua-tetraaquabis(μ-2-hydroxy-4-oxocyclobut-1-ene-1,3-diolatostrontium] hemihydrate

    Directory of Open Access Journals (Sweden)

    Amira Bouhali

    2011-08-01

    Full Text Available In the title coordination polymer, {[Sr(C4HO42(H2O5]·0.5H2O}n, the Sr2+ ion is coordinated by three monodentate hydrogensquarate (hsq anions and six aqua ligands in a distorted SrO9 monocapped square-antiprismatic geometry. The hsq anions and water molecules bridge the metal ions into infinite sheets lying parallel to (100. The O atom of the uncoordinated water molecule lies on a crystallographic twofold axis. The packing is stabilized by numerous O—H...O hydrogen bonds.

  1. Bactericidal dental nanocomposites containing 1,2,3-triazolium-functionalized POSS additive prepared through thiol-ene click polymerization.

    Science.gov (United States)

    Burujeny, Saeed Beigi; Yeganeh, Hamid; Atai, Mohammad; Gholami, Hoshyar; Sorayya, Marziyeh

    2017-01-01

    Deterioration of mechanical strength for the dental composite containing ionic bactericidal compounds restricts the widespread utilization of this class of useful materials. This problem is originated from the reduction of the intermolecular interaction of polymeric network due to plasticization effect of absorbed water molecules penetrated between the chain segments. The main goal of this study is the synthesis of the highly efficient bactericidal additive with low hydrophilicity and consequently the least adverse effect on the final mechanical strength of the dental composite. The bactericidal 1, 2, 3-triazolium functional groups were chemically anchored on the surface of hydrophobic POSS nanoparticles (Triazolium-POSS) and incorporated into a dental restorative system composed of a ternary thiol-allyl ether-methacrylate resin and glass fillers. A similar system was also prepared, in which the POSS additive was replaced with quaternized dimethyl aminoethyl methacrylate monomer (DMAEMA-BC). The chemical structure of POSS derivatives was evaluated by 1 HNMR and FTIR spectra. The water uptake of dental composites was evaluated at days 1 and 14 after immersion into water. The bactericidal activity of composite specimens against Streptococcus mutans (ATCC 35668) was determined based on ASTM E 2180 - 07. The flexural properties of samples were investigated through three-point bending assay and the shrinkage-strain of photo-cured resins was measured using the bonded-disk technique. The degree of conversion (DC %) of methacrylate functions was followed by FTIR spectroscopy. MTT assay was performed to investigate the cytocompatibility of samples. Regardless of the partial increase in water uptake for Triazolium-POSS-containing sample, this parameter was much favor than the composite made from DMAEMA-BC. Therefore, the lower decline in flexural properties was recorded under the wet condition for the former system. Incorporation of Triazolium-POSS had no significant effect on shrinkage strain and cytocompatibility of composite specimen, meanwhile, a higher degree of conversion of methacrylate functional groups was recorded. The Triazolium-POSS-containing nano composite showed significantly higher bactericidal activity against Streptococcus mutans than another studied model system. The new derivative of bactericidal POSS nanoparticles decorated with 1, 2, 3-Triazolium moieties is a highly efficient bactericidal compound. If Triazolium-POSS is incorporated into a proper dental resin formulation, it can provide a strong bactericidal activity for dental materials; in the meantime, it leads to minimum deterioration of their mechanical strength due to its low water uptake. Copyright © 2016 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  2. Synthesis of novel carbocyclic nucleoside analogues containing bicyclo[2.2.1]hept-2-ene-2-methanol

    Czech Academy of Sciences Publication Activity Database

    Hřebabecký, Hubert; Dračínský, Martin; Holý, Antonín

    2008-01-01

    Roč. 73, č. 1 (2008), s. 44-58 ISSN 0010-0765 R&D Projects: GA MŠk 1M0508; GA AV ČR 1QS400550501; GA ČR GA203/05/0132 Institutional research plan: CEZ:AV0Z40550506 Keywords : carbocyclic nucleosides * purines * norbornenes Subject RIV: CC - Organic Chemistry Impact factor: 0.784, year: 2008

  3. Eugene O'Neill "Pikk päevatee kaob öösse" / Ellu Eik ; interv. Ene Paaver

    Index Scriptorium Estoniae

    Eik, Ellu

    2008-01-01

    Seoses Eesti Draamateatri suvelavastusega "Pikk päevatee kaob öösse" (autor Eugene O'Neill ja lavastaja Merle Karusoo) räägib Lääne-Tallinna Keskhaigla Sõltuvusravikeskuse psühhiaater Ellu Eik sõltuvuse tagamaadest ja mõjudest

  4. Perspectives on the emblems of the nation in contemporary Estonian and Anglo-Welsh poetry / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet, 1968-

    2000-01-01

    Kaasaegse eesti luule ja Walesi ingliskeelse luule võrdlemiseks on kasutatud uusi antoloogiaid: Eesti luule antoloogia II (koost. Raivo Kuusk, 1998), Twentieth-century anglo-welsh poetry (ed. Dannie Abse, 1997)

  5. Eesti viipekeele kasutamise õiguse tagamine Eestis : [magistritöö] / Hendrick Rang ; Tartu Ülikool, õigusteaduskond ; juhendaja: Ene Andresen

    Index Scriptorium Estoniae

    Rang, Hendrick

    2014-01-01

    Kurtusest ja viipekeelest, viipekeele kui keele reguleerimisest, viipekeele kui puuet kompenseeriva suhtlusabivahendi reguleerimisest rahvusvahelises õiguses, viipekeele õiguslikust seisundist Eestis

  6. Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene (TPX with cRGD pentapeptide

    Directory of Open Access Journals (Sweden)

    Lena Möller

    2013-02-01

    Full Text Available Covalent multistep coating of poly(methylpentene, the membrane material in lung ventilators, by using a copper-free “click” approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly(methylpentene surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.

  7. Rantsev v. Chipre & Rusia, App. No. 25965/04 (Eur. Ct. H.R. Ene. 7, 2010

    Directory of Open Access Journals (Sweden)

    Catharine A. MacKinnon

    2011-10-01

    Full Text Available En el artículo se analiza el caso Rantsev para determinar qué logra, y qué no logra, para enfrentar efectivamente la trata de mujeres; comentando favorablemente sus decisiones en materia de libertad, tortura y esclavitud y criticando parcialmente su decisión sobre el derecho a la vida. Las similitudes y convergencias que existen entre la agresión contra las mujeres y la prostitución, ambas entendidas como prácticas de desigualdad sexual, se consideran bases realistas y constructivas para el enfoque de la trata de mujeres.

  8. Söötmisega disainitud piim tagab tervisliku toidukraami / Ene Tammsaar ; intervjueerinud Ain Alvela ; kommenteerinud Üllas Jaaska

    Index Scriptorium Estoniae

    Tammsaar, Ene, 1952-

    2014-01-01

    Et farmidest tööstusse minevast toorpiimast saaks toota maitsvaid ja tervislikke tooteid, peab toorpiim olema kõrgeima võimaliku kvaliteediga. Selle tagamiseks on piimatööstused koostöös teadlastega ette võtnud piima koostise disainimise

  9. Notari ametivastutuse alused : [bakalaureusetöö] / Monika Palu ; Tartu Ülikool, õigusteaduskond ; juhendaja: Ene Andresen

    Index Scriptorium Estoniae

    Palu, Monika

    2006-01-01

    Notari õiguslik seisund ja funktsioonid, vastutuse üldiseloomustus, ametivastutuse regulatsiooni areng, notari vastu esitatava kahju hüvitamise nõude võrdlus riigivastutuse seaduse alusel haldusorgani vastu esitatava kahju hüvitamise nõudega

  10. Maja Cap Ferret's Prantsusmaal : võtmesõnaks on ökoarhitektuur / Anne Prommik, Ene Läkk

    Index Scriptorium Estoniae

    Prommik, Anne

    1999-01-01

    Mere kaldale puude vahele rajatud, saledatele tugisammastele tõstetud ranges stiilis maja on avatud vaid Archachoni rannale. Looduse säilitamiseks on iga maja läbiva puutüve ümber ehitatud metallkonstruktsioon. Tüved läbivad liigutatavat katust kummist 'varruka' kaudu. Projekteerija: Lacaton et Vassal (Bordeaux).

  11. d ie penne st rydtu sse nd ie chr ist ene en he id eneg ed ur en ded ...

    African Journals Online (AJOL)

    Test

    is so oud as die Christendom self. Die doel van hierdie artikel is om kortliks na te gaan waiter aanvalle die Christene gedurende die eerste drie eeue van die kant van die heidene geleerdes ondervind, en hoe hulle daarop reageer het. Die heidense letterkunde tot ongeveer die middel van die tweede eeu bevat besonder ...

  12. Uroboros : [aus "Uroboros"] : [luuletused] / Ene Mihkelson ; tlk. Irja Grönholm ja Gisbert Jänicke

    Index Scriptorium Estoniae

    Mihkelson, Ene, 1944-2017-

    2006-01-01

    Sisu: Uroboros : "In der Nacht fragt heimlich jemand Wie heisst du..." ; "Am Meer stand ein Mann mit einer Sense..." ; "An dem Tag als es Kugeln regnete..." ; "Zum Zeitvertrieb ersteigerte ich mir auf einer Auktion ein paar..." ; "Sie hat sich mit der Zeit eingelassen und daraus..." ; Das Feld ; "Mutter ist wieder bei mir obgleich..." ; "Wir waren ein Mädchen Wir redeten..." ; "Als ich vier Jahre alt wurde Da wurde so viel..." ; "Wer ist dein Vater Der Fremde aus der Ferne..." ; "Das letzte Wort Das letzte Das letzte Das allein...". Orig.: Uroboros : "Öö aegu keegi küsib sala Mis su nimi on..." ; "Mere ees seisis vikatiga mees..." ; "Sel päeval kui sadas kuulivihma..." ; "Ajaviiteks ostsin enampakkumisel sõpru..." ; "Ta ajaga läinud on sohki ja sellest..." ; Põld ; "Mu ema on jälle mu juures kuigi..." ; "Meid oli üks türduk Me rääkisime..." ; "Kui olin saanud neljaseks Nii väga kiitis..." ; "Kes on su isa Kaugelt tulnud võõras..." ; "Viimast sõna Viimast Viimast Ainu..."

  13. L’HARMONISATION DE LA FISCALITÉ ENVIRONNEMENTALE DANS L’UNION EUROPÉENE : UNE ÉTUDE COMPARATIVE

    Directory of Open Access Journals (Sweden)

    Toma Elena

    2009-05-01

    Full Text Available Environmental protection issues took magnitude in recent years, being included on the list of priorities of the European Union. To reduce the negative externalities, a solution of compromise is taxing products whose consumption or production creates pollu

  14. Light-induced switching of 1,3-diazabicyclo-[3.1.0]hex-3-enes on gold nanoparticles

    Science.gov (United States)

    Mahmoodi, Nosrat O.; Ahmadi, Narges Khatoon; Ghavidast, Atefeh

    2018-05-01

    The fabrication of hybrid nanoassemblies involving sulfure-modified photochromic derivatives (SMPDs) on the gold nanoparticles (AuNPs) was carried out to investigate the influence of AuNPs surface plasmons on the SMPDs photoisomerization. The size of the AuNPs obtained was <30 nm in average diameter. Upon irradiation by alternating UV and Vis light, a reversible photochemical isomerization along with bathochromic shift in the absorption band takes place on the surface of the AuNPs in analogy with free SMPDs in solutions. Furthermore, in some cases a significant quenching of photochromic reactivity was observed due to the excited energy transfer from the photochromic molecules to the AuNPs core.

  15. Sphinganine-Like Biogenesis of (E)-1-Nitropentadec-1-ene in Termite Soldiers of the Genus Prorhinotermes

    Czech Academy of Sciences Publication Activity Database

    Jirošová, Anna; Majer, Pavel; Jančařík, Andrej; Dolejšová, Klára; Tykva, Richard; Šobotník, Jan; Jiroš, Pavel; Hanus, Robert

    2014-01-01

    Roč. 15, č. 4 (2014), s. 533-536 ISSN 1439-4227 R&D Projects: GA ČR GP13-25137P Institutional support: RVO:61388963 Keywords : biosynthesis * natural products * nitro compounds * Prorhinotermes * termites Subject RIV: CE - Biochemistry Impact factor: 3.088, year: 2014

  16. UV Laser Photolysis of Silacyclopent-3-ene: Effect of Admixtures on Nature of Chemically Vapour-Deposited Organosilicon Films

    Czech Academy of Sciences Publication Activity Database

    Urbanová, Markéta; Pola, Josef

    2002-01-01

    Roč. 16, č. 10 (2002), s. 580-586 ISSN 0268-2605 R&D Projects: GA ČR GA104/00/1294 Keywords : chemical vapour deposition * organisilicon films * laser photolysis Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.286, year: 2002

  17. Ene News April 2003 - Information on energy research (German version); ENET News, April 2003, Nr. 54 deutsch

    Energy Technology Data Exchange (ETDEWEB)

    Wellstein, J.

    2003-07-01

    The April 2003 issue of ENET News, a magazine on energy research in Switzerland published three times a year, covers the topics of energy use in industry, the export of sustainable energy technologies and reviews the Swiss Research Concept for the period 2004 - 2007. Further articles discuss technology transfer from research institutes to industry, technology monitoring, new photovoltaic technologies, new techniques for the recycling of metal, wood energy and the energetic use of biogas from wastewater treatment plants and of drainage water from alpine tunnels. Further, small hydro schemes are described, the hydronics of small heat pump systems are discussed and the efficient use of fossil fuels in combined heat and power / heat pump combinations is examined. Other topics covered include low-energy consumption building, nuclear reactor safety and biomass-based fuels.

  18. Villa Jaapanis Nagano maakonnas : võtmesõnaks on ökoarhitektuur / Anne Prommik, Ene Läkk

    Index Scriptorium Estoniae

    Prommik, Anne

    1999-01-01

    Tokio lähedal metsa keskel asuv kunstigalerii omanikust tellija villa, kus on ruum kunstiteoste eksponeerimiseks ja korter kahe magamistoa ning loodusvaatega vannitoaga. Maja baaselemendiks on ring. Planeeringus on tõmmatud kindlapiiriline joon avaliku ja eluruumi vahele (machiya-disain). Arhitekt Kazuyo Sejima & Associates.

  19. Using Mise-En-Sc\\`ene Visual Features based on MPEG-7 and Deep Learning for Movie Recommendation

    OpenAIRE

    Deldjoo, Yashar; Quadrana, Massimo; Elahi, Mehdi; Cremonesi, Paolo

    2017-01-01

    Item features play an important role in movie recommender systems, where recommendations can be generated by using explicit or implicit preferences of users on traditional features (attributes) such as tag, genre, and cast. Typically, movie features are human-generated, either editorially (e.g., genre and cast) or by leveraging the wisdom of the crowd (e.g., tag), and as such, they are prone to noise and are expensive to collect. Moreover, these features are often rare or absent for new items...

  20. E-poliitika ärikeskkonna kujundajana : kaubanduse ja kinnisvaraturu näitel / Ene Kolbre, Urve Venesaar

    Index Scriptorium Estoniae

    Kolbre, Ene, 1946-

    2003-01-01

    Ülevaade infotehnoloogia kasutamise tingimustest äris üldiselt, veidi põhjalikumalt internetikaubanduses ja kinnisvaraturul, toetudes kirjanduse, Eesti ärikeskkonna ja e-poliitika arengu analüüsile

  1. Goethe loob väljendi : maailmakirjanduse kultuuripoliitika / David Damrosch ; tõlkinud Ene-Reet Soovik

    Index Scriptorium Estoniae

    Damrosch, David

    2007-01-01

    Johann Wolfgang von Goethe erasekretäri Peter Eckermanni teosest "Vestlused Goethega tema elu viimastel aastatel", Goethe vaadetest kirjandusele, maailmakirjanduse mõisest. Ka kirjanduse tõlkimisest tänapäeval, sinoloog Stephen Oweni vaadetest ja hiina luuletaja Bei Dao luulest. Artikkel sisaldab ka Bei Dao luuletuste näiteid

  2. N 1,N 4-Bis(2-thienylmethyl­ene)cyclo­hexane-1,4-diamine

    Science.gov (United States)

    Lee, Kyung-Eun; Lee, Soon W.

    2009-01-01

    The title compound, C16H18N2S2, lies about an inversion center with only half of the mol­ecule in the asymmetric unit. The cyclo­hexane ring adopts a chair conformation, and the terminal thio­phene rings are in a transoid orientation, with an S⋯S separation between the two terminal 2-thio­phene rings of 11.6733 (9) Å. PMID:21577846

  3. Educational objectives as the basis for successful coping at school / Leida Talts, Ene Mägi, Helle Sikka... [jt.

    Index Scriptorium Estoniae

    2007-01-01

    Artiklis käsitletakse sotsiaalsete ja eetiliste eesmärkide saavutatust kooliminevate laste rühmades ja esimese kooliaasta lõpus. Uurimus tugineb kolmele küsitlusele, mis viidi läbi ajavahemikus 2002-2004

  4. Valimiskomisjonide otsuste ja toimingute vaidlustamine : [bakalaureusetöö] / Ene Soop ; Õigusinstituut ; juhendaja: Enn Markvart

    Index Scriptorium Estoniae

    Soop, Ene, 1974-

    1998-01-01

    Avalduste ja kaebuste esitamine, tähtajad, valimiskaebused konstitutsioonikohtus, kaebuste lahendamise erinevad viisid ja tähtajad, võimalikud parandused ja muudatused, keelenõudega seonduvad protestid.Vt. ka Õigusinstituudi toimetised (1998) nr. 1, lk. 10-11

  5. Energy saving metal plating new method which does not issue the drainage; Haisui wo dasanai sho ene kinzoku mekki shishuho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-10-01

    Toyo Gurahoiru developed the epoch-making metal plating liquid in which the drainage did not arise. In organic solvent dispersion solution of metal sulfide powder and special epoxy resin, fluororesin fine powder, after the object is soaked, it is made to dry by the printing furnace, and it hardens, processing coat which arranged the metal sulfide powder on the surface base in the leafy state is formed. Cleaning and electrolytic process require heat-resistant. rust-prevention fixity excellent. (translated by NEDO)

  6. Tänavune provintsiteatripäev soovis Koidulaulikule õnne sünnipäevaks / Ene Kallas

    Index Scriptorium Estoniae

    Kallas, Ene

    2008-01-01

    Muljeid Saaremaa 11. provintsiteatripäevalt, mis pühendatud Lydia Koidula 165. sünniaastapäevale. Kuus näiteseltskonda esitas Koidula näidendid "Kosjakased", "Säärane mulk ehk Sada vakka tangusoola", "Saaremaa onupoeg" ja Tõnis Kipperi versiooni näidendist "Kosjaviinad" ning luulekompositsiooni "Mu isamaa on minu arm"

  7. Rootsilik lapsepõlv ängi ja päikesepaiste vahel / Ene-Reet Soovik

    Index Scriptorium Estoniae

    Soovik, Ene-Reet, 1968-

    2007-01-01

    Arvustus: Tranströmer, Tomas. Suur on mõistatus ; Mälestused seiravad mind / rootsi keelest tõlkinud Tõnis Arnover ja Lennart-Hans Jürgenson ; järelsõna: Tõnis Arnover. Tallinn : Kultuurileht, 2007. (Loomingu raamatukogu ; 27)

  8. Wetting of Functionalized Polyethylene Film Having Ionizable Organic Acids and Bases at the Polymer-Water Interface: Relations between Functional Group Polarity, Extent of Ionization, and Contact Angle with Water.

    Science.gov (United States)

    1988-03-01

    Figure 17 and for the sulfonamides and fluorinated ainides shown in Figures 9 and 15. The labels correspond to the labels used in those figures; A12’ and...soaked in 30 mL of Jry diethyl ether quickly removed and used immediately without workup t.o mini,nize hydrolysis of the acid chloride groups by

  9. A facile route to end-functionalised polymers synthesised by SET-LRP via a one-pot reduction/thiol-ene Michael-type addition.

    Science.gov (United States)

    Syrett, Jay A; Jones, Mathew W; Haddleton, David M

    2010-10-14

    We report the facile synthesis of well defined, disulfide containing polymers via SET-LRP. A one-pot reduction/conjugation reaction enables post polymerisation modification with functional (meth)acrylates and acrylamides.

  10. Factores asociados a Malaria en el Distrito de Llochegua, Valle de los Ríos Apurimac y Ene, Provincia de La Mar, Ayacucho - Perú - 2003.

    Directory of Open Access Journals (Sweden)

    Ricardo Carreño Escobedo

    2009-07-01

    Full Text Available Objetivo: Estimar los factores asociados para enfermar de Malaria en Llochegua - Ayacucho - Perú en el año 2003. Material y métodos: Estudio caso-control, randomizado, pareado por edad y sexo, considerando 95% de significancia, error beta 0,05 y una razón 1:1, se estimó una muestra de 55 casos. Se estudiaron los siguientes factores de riesgo: número de individuos en la casa, limpieza fuera de la casa, baño diario, uso de mosquitero, uso adecuado de mosquitero, exposición al vector entre las 18.00 y 21.00 horas y distancia de la casa a 200 m de cualquier fuente de agua estancada. Resultados: El uso adecuado de mosquitero (OR= 0,116; IC 95% 0,033-0,342, distancia de casa a 200 m o más de una fuente de agua estancada (OR= 0,112; IC 95%: 0,031 - 0,334, resultaron factores protectores. La regresión logística mostró: los que usan adecuadamente mosquitero tienen 85% menos chance de enfermar de malaria en comparación con los que no (p=0,001; IC 95%: 0,052 - 0,441, independiente de la distancia a la fuente de agua estancada, limpieza dentro casa y uso de mosquitero. Los que viven cerca de aguas estancadas tienen 6,6 veces más probabilidad de hacer malaria (p=0,001; IC 95%: 2,247-19,506; independientemente del uso del mosquitero, limpieza dentro casa y uso adecuado de mosquitero. Conclusiones: La distancia a la fuente de agua estancada ≥ 200 metros y el uso apropiado de mosquiteros son factores predictivos protectores de evitar enfermedad. (Rev Med Hered 2009;20:139-145.

  11. Riigisaladus kui informatsioonivabaduse piirang ja sellele juurdepääs : [bakalaureusetöö] / Ene Lehiste ; Tartu Ülikool, õigusteaduskond ; juhendaja: Kalle Merusk

    Index Scriptorium Estoniae

    Lehiste, Ene

    2001-01-01

    Salastatud info kui infovabaduse piirang, riigisaladuse mõiste kehtivas õiguses, salastatud teabe kaitse meetodid, riigisaladuse juurdepääsu alused, julgeolekukontrolli läbiviimine (NATO-s, WEU-s)

  12. v—te ql—™i—l —nd rolo™ene €—leolimnology of two temper—te l ...

    Indian Academy of Sciences (India)

    IQgGIPg v—ri—tions in tree rings x—ture PWU PVEEQI q—rdner ‡ ƒD x—lep— „ pD prez i eD gi™ho™hi i e —nd v—ndrum € p IWVS ƒe—son—l p—ttern in lipid ™ontent of v—ke wi™hig—n m—™roEinverte˜r—tes g—n—di—n tourn—l pishF equ—tF ƒ™iF RP IVPUEEIVQP roll—nder h t —nd w™uenzie t e IWWI gyP ...

  13. (1RS,4RS,5RS-Methyl 2-(3,5-dinitrobenzoyl-2-oxa-3-azabicyclo[3.3.0]oct-7-ene-4-carboxylate

    Directory of Open Access Journals (Sweden)

    Xerardo Garcia-Mera

    2009-05-01

    Full Text Available The title compound, C15H13N3O8, comprises two crystallographically independent molecules in the asymmetric unit. In the crystal, intermolecular C—H...O hydrogen bonds link the molecules and short C=O...π contacts are seen.

  14. Method for greenhouse gas emission assessments according to the article 75 of the 2010-788 law of July 12, 2010 bearing national commitment for the environment (ENE)

    International Nuclear Information System (INIS)

    2011-01-01

    This document presents mandatory methodological principles, optional prescriptions and optional recommendations for the assessment of greenhouse gas emissions. After having recalled some basic definitions, and regulatory arrangements and performance principles for greenhouse gas emission assessment, this document proposes a diagram indicating the main steps of such an assessment. It defines the organisational frame (for companies or communities), presents the concept of operational perimeter. It reviews the general principles of the assessment: global approach and priorities, calculation with respect to measurement, emission factors, gas global warming potential, reporting and reference year, uncertainty management, case of electricity, case of biomass CO 2 , cogeneration and electricity production from renewable energy, compensation. It presents the reporting format. Some aspects are more precisely presented or described in appendix

  15. Tööjõuvahetus viib teise keskkonda : mida kogesid Ida-Virumaa raamatukoguhoidjad Pärnus ja Rakveres töötades / Ene Riet

    Index Scriptorium Estoniae

    Riet, Ene, 1954-

    2010-01-01

    Integratsiooni ja Migratsiooni Sihtasutuse Meie Inimesed tööjõuvahetusprogrammis osalenud räägivad oma muljetest. Pärnu Keskraamatukogus töötasid Kohtla-Järve Keskraamatukogu töötajad Tatjana Agafonova ja Alla Rõtova ning vastuvõtjateks ja tugiisikuteks olid Lenna Eliste, Krista Visas ja Heinike Sinijärv. Lääne-Virumaa Keskraamatukogus olid Jõhvi Keskraamatukogu töötajad Natalja Jakovleva ja Tamara Saar, vastu võtsid Leigi Kütt ja Lea Lehtmets

  16. CCDC 820903: Experimental Crystal Structure Determination : (eta^5^-pentamethylcyclopentadienyl)-(1-benzyl-3-[tri(propan-2-yl)-phosphanylidene]triaz-1-ene)-chloro-ruthenium

    KAUST Repository

    Lamberti, Marina

    2013-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  17. Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation.

    Directory of Open Access Journals (Sweden)

    Lauryn Samelko

    Full Text Available Cobalt alloy debris has been implicated as causative in the early failure of some designs of current total joint implants. The ability of implant debris to cause excessive inflammation via danger signaling (NLRP3 inflammasome vs. pathogen associated pattern recognition receptors (e.g. Toll-like receptors; TLRs remains controversial. Recently, specific non-conserved histidines on human TLR4 have been shown activated by cobalt and nickel ions in solution. However, whether this TLR activation is directly or indirectly an effect of metals or secondary endogenous alarmins (danger-associated molecular patterns, DAMPs elicited by danger signaling, remains unknown and contentious. Our study indicates that in both a human macrophage cell line (THP-1 and primary human macrophages, as well as an in vivo murine model of inflammatory osteolysis, that Cobalt-alloy particle induced NLRP3 inflammasome danger signaling inflammatory responses were highly dominant relative to TLR4 activation, as measured respectively by IL-1β or TNF-α, IL-6, IL-10, tissue histology and quantitative bone loss measurement. Despite the lack of metal binding histidines H456 and H458 in murine TLR4, murine calvaria challenge with Cobalt alloy particles induced significant macrophage driven in vivo inflammation and bone loss inflammatory osteolysis, whereas LPS calvaria challenge alone did not. Additionally, no significant increase (p500pg/mL. Therefore, not only do the results of this investigation support Cobalt alloy danger signaling induced inflammation, but under normal homeostasis low levels of hematogenous PAMPs (<2pg/mL from Gram-negative bacteria, seem to have negligible contribution to the danger signaling responses elicited by Cobalt alloy metal implant debris. This suggests the unique nature of Cobalt alloy particle bioreactivity is strong enough to illicit danger signaling that secondarily activate concomitant TLR activation, and may in part explain Cobalt particulate associated inflammatory and toxicity-like reactions of specific orthopedic implants.

  18. Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation

    Science.gov (United States)

    Samelko, Lauryn; Landgraeber, Stefan; McAllister, Kyron; Jacobs, Joshua; Hallab, Nadim James

    2016-01-01

    Cobalt alloy debris has been implicated as causative in the early failure of some designs of current total joint implants. The ability of implant debris to cause excessive inflammation via danger signaling (NLRP3 inflammasome) vs. pathogen associated pattern recognition receptors (e.g. Toll-like receptors; TLRs) remains controversial. Recently, specific non-conserved histidines on human TLR4 have been shown activated by cobalt and nickel ions in solution. However, whether this TLR activation is directly or indirectly an effect of metals or secondary endogenous alarmins (danger-associated molecular patterns, DAMPs) elicited by danger signaling, remains unknown and contentious. Our study indicates that in both a human macrophage cell line (THP-1) and primary human macrophages, as well as an in vivo murine model of inflammatory osteolysis, that Cobalt-alloy particle induced NLRP3 inflammasome danger signaling inflammatory responses were highly dominant relative to TLR4 activation, as measured respectively by IL-1β or TNF-α, IL-6, IL-10, tissue histology and quantitative bone loss measurement. Despite the lack of metal binding histidines H456 and H458 in murine TLR4, murine calvaria challenge with Cobalt alloy particles induced significant macrophage driven in vivo inflammation and bone loss inflammatory osteolysis, whereas LPS calvaria challenge alone did not. Additionally, no significant increase (p500pg/mL). Therefore, not only do the results of this investigation support Cobalt alloy danger signaling induced inflammation, but under normal homeostasis low levels of hematogenous PAMPs (<2pg/mL) from Gram-negative bacteria, seem to have negligible contribution to the danger signaling responses elicited by Cobalt alloy metal implant debris. This suggests the unique nature of Cobalt alloy particle bioreactivity is strong enough to illicit danger signaling that secondarily activate concomitant TLR activation, and may in part explain Cobalt particulate associated inflammatory and toxicity-like reactions of specific orthopedic implants. PMID:27467577

  19. Ärkav kaunitar : I rahvusvaheline teatrifestival "Talveöö unenägu" 28. -31. XII 2000 Tallinna Linnateatris / Ene Paaver

    Index Scriptorium Estoniae

    Paaver, Ene, 1963-

    2001-01-01

    Rahvusvaheline festival "Talveöö unenägu" Tallinna Linnateatris 28.- 30. dets. Lavastused : "K. I. Kuritööst" (lav. Kama Ginkas, Moskva Noorsooteater), "Gargantua ja Pantagruel" (lav. Stanislavas Rubinovas, Kaunase Noorsooteater), "Preili Pollinger" (lav. Edith Koerber, Saksa Tri-Bühne), "Rusudekorjajad" (lav. Nika Brettschneider, Viini Brett Theater)

  20. Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation.

    Science.gov (United States)

    Samelko, Lauryn; Landgraeber, Stefan; McAllister, Kyron; Jacobs, Joshua; Hallab, Nadim James

    2016-01-01

    Cobalt alloy debris has been implicated as causative in the early failure of some designs of current total joint implants. The ability of implant debris to cause excessive inflammation via danger signaling (NLRP3 inflammasome) vs. pathogen associated pattern recognition receptors (e.g. Toll-like receptors; TLRs) remains controversial. Recently, specific non-conserved histidines on human TLR4 have been shown activated by cobalt and nickel ions in solution. However, whether this TLR activation is directly or indirectly an effect of metals or secondary endogenous alarmins (danger-associated molecular patterns, DAMPs) elicited by danger signaling, remains unknown and contentious. Our study indicates that in both a human macrophage cell line (THP-1) and primary human macrophages, as well as an in vivo murine model of inflammatory osteolysis, that Cobalt-alloy particle induced NLRP3 inflammasome danger signaling inflammatory responses were highly dominant relative to TLR4 activation, as measured respectively by IL-1β or TNF-α, IL-6, IL-10, tissue histology and quantitative bone loss measurement. Despite the lack of metal binding histidines H456 and H458 in murine TLR4, murine calvaria challenge with Cobalt alloy particles induced significant macrophage driven in vivo inflammation and bone loss inflammatory osteolysis, whereas LPS calvaria challenge alone did not. Additionally, no significant increase (p500pg/mL). Therefore, not only do the results of this investigation support Cobalt alloy danger signaling induced inflammation, but under normal homeostasis low levels of hematogenous PAMPs (alloy metal implant debris. This suggests the unique nature of Cobalt alloy particle bioreactivity is strong enough to illicit danger signaling that secondarily activate concomitant TLR activation, and may in part explain Cobalt particulate associated inflammatory and toxicity-like reactions of specific orthopedic implants.

  1. Disclosure of Professional Secrecy – A Criminal Law Analysis and Dilemmas (Dileme kaznivega dejanja neupravičene izdaje poklicne skrivnosti

    Directory of Open Access Journals (Sweden)

    Miha Šepec

    2017-12-01

    Full Text Available Disclosure of professional secrecy is incriminated in Article 142 of the Slovenian Penal Code (KZ-1. The offence protects the privacy of individuals in order to protect them from abuse when personal information and secrets are communicated to persons of certain professions (doctors, lawyers, priests, etc.. The issue is analyzed briefly; however, the context raises extremely complex dogmatic issues, particularly in the direction when unlawfulness of the crime shall be excluded, whether it is reasonable that such a complex offence is not prosecuted ex officio or upon request by the injured person, and the nature of relationship between the offence of disclosure of professional secrecy according to Article 142 and offences under Articles 280 (Failure to Inform Authorities of Preparations for Crime and 281 (Failure to Provide Information of Crime or Perpetrator of the Slovenian Penal Code. The aim of this paper is to highlight some legal dogmatic issues that have not yet been discussed in legal practice. On the other hand, the authors would also like to urge the legislature to amend the current criminal offence of disclosure of professional secrecy.

  2. Rahapesu ja terrorismi rahastamise tõkestamise seaduse kohaldamise probleemid notarite ametitegevuses : [magistritöö] / Veronika Aunpu ; Tartu Ülikool, õigusteaduskond ; juhendaja: Ene Andresen

    Index Scriptorium Estoniae

    Aunpu, Veronika

    2009-01-01

    Notarite kaasamisest rahapesu ja terrorismi rahastamise tõkestamiseks, tugevdatud hoolsusmeetmete kohaldamise vajalikkusele osundavatest riskidest notari ametitegevuses, notari kohustustest rahapesu või terrorismi rahastamise kahtlusega tehingute korral

  3. Mass spectrometric analysis of oxygenations in aromatization of androst-4-ene-3,6,17-trione, a suicide substrate of aromatase, by placental microsomes. Isotope effect and stereochemistry.

    Science.gov (United States)

    Numazawa, Mitsuteru; Takahashi, Madoka; Nagaoka, Masao; Handa, Wakako; Yamashita, Kouwa

    2007-01-01

    Aromatase catalyzes the conversion of androstenedione (AD) to estrone through three sequential oxygenations of the 19-methyl group. 6-OxoAD (1) is one of the typical suicide substrates of aromatase, which is converted by aromatase to 6-oxoestrone through 19-alcohol (19-ol) and 19-aldehyde (19-al) intermediates 2 and 3. To study the deuterium isotope effect on the conversion of 19-ol 2 to 19-al 3 as well as the stereochemistry of the 19-hydrogen removal in this conversion, we initially synthesized [19,19-(2)H(2)] and [19S- or 19R-(2)H] 19-ols 2, starting from the corresponding deuterium-labeled 19-hydroxyAD derivatives. In incubation of non-labeled and [19,19-(2)H(2)]-labeled 19-ol 2 or that of their 1:1 mixture with human placental microsomes in the presence of NADPH under air, there was no significant deuterium-isotope effect on the production of the aromatized product 6-oxoestrone or on the conversion of 19-ol 2 to 19-al 3, based on gas chromatography-mass spectrometric analysis of the estrogen product or liquid chromatography-mass spectrometric (LC-MS) analysis of the deuterium contents of the product 19-al 3 and the recovered 19-ol 2. Moreover, in the incubations of [19S-(2)H] 19-ol 2 and its 19R isomer, LC-MS analysis of the product 3 demonstrated that the 19-pro-R hydrogen atom was stereospecifically removed in the conversion of 19-ol 2 to 19-al 3. These findings indicate that the 19-oxygenation of 19-ol 2 would proceed in the same mechanism as that involved in the AD aromatization.

  4. Kogesime suurepärast meeskonnatööd / Liisi Lembinen, Elena Sipria-Mironov ; intervjueerinud Õnne Mets, Ene Riet

    Index Scriptorium Estoniae

    Lembinen, Liisi

    2014-01-01

    Tartu Ülikooli Raamatukogu osales EOD-projektis 2009. aasta maist kuni 2014. aasta aprillini. Kuidas projekt toimis ja mida saavutati, vastavad direktori kt Liisi Lembinen ja projektijuht Elena Sipria-Mironov

  5. VIP EE, Ms Ene Ergma, President of the Estonia Parliament (Riigikogu), Republic of Estonia (attending the 3rd World Conference of Speakers of Parliament in Geneva)

    CERN Multimedia

    2010-01-01

    She toured the LHC superconducting magnet test hall with Andrzej Siemko, leader of the machine protection and electrical integrity group in the technology department, and also saw the CERN Control Centre, the CMS experiment and the LHC tunnel.

  6. Planning and acceptance of catenaries with reference to the High-Speed Energy TSI; Planung und Abnahme von Oberleitungen unter Bezugnahme auf die TSI ENE HGS

    Energy Technology Data Exchange (ETDEWEB)

    Schnadhorst, Kai [Balfour Beatty Rail GmbH, Essen (Germany); Tessun, Heinz [Balfour Beatty Rail GmbH, Muenchen (Germany)

    2011-07-15

    It was in May 2002 that the first-ever Technical Specification for Interoperability (TSI) of the ''energy'' subsystem with validity throughout the European Union was adopted. In March 2008, this was then repealed in conjunction with the adoption of a revised TSI. The new decision has brought fresh movement into this field. (orig.)

  7. Üldine kaubandus (toidukaupade turg) : toidukaupade väliskaubanduse bilanss [2003-2004] / Õrne Pill, Liia Laanes, Ene Maadvere

    Index Scriptorium Estoniae

    Pill, Õrne

    2005-01-01

    Ilmunud ka: Agriculture and the development of rural life : overview 2004/2005. - Tallinn, 2005, lk. 55-65. Põllumajandussaaduste ekspordimaht kasvas eelmise aasta sama perioodiga võrreldes 5,1% ning impordimaht vähenes 1,8%, kaubandusbilansi negatiivne saldo moodustas 4507,7 mln krooni. Diagrammid

  8. Phenom ´ enes d’h ` esitation dans des sayn ´ etes jou ` ees ´ par des el´ eves d’immersion

    Directory of Open Access Journals (Sweden)

    Olivier Malet

    2005-06-01

    Full Text Available Abstract The aim of this paper is to examine temporal variables (speech rate, average length and placement of pauses, etc. and other types of hesitation phenomena (repetition of syllables, words and sequences, reformulations and self-corrections found in two short sketches produced by thirty-one Grade 7 students enrolled in an Ontario French Immersion program. The results of our analysis show that Immersion students speak as quickly as or even more quickly than Francophones but do not use pause duration as an indicator of the nature of syntactic boundaries (minor vs. major. These students also produce a large number of phrase internal pauses and hesitations. These numerous interruptions have a negative impact on the intelligibility of their speech output.

  9. CCDC 889630: Experimental Crystal Structure Determination : Chloro-(eta^2^-pent-2-ene-1,5-diylbis(di-t-butylphosphine))-rhodium

    KAUST Repository

    Hayashi, Yukiko

    2013-01-01

    An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

  10. Atypical McMurry Cross-Coupling Reactions Leading to a New Series of Potent Antiproliferative Compounds Bearing the Key [Ferrocenyl-Ene-Phenol] Motif

    Directory of Open Access Journals (Sweden)

    Pascal Pigeon

    2014-07-01

    Full Text Available In the course of the preparation of a series of ferrocenyl derivatives of diethylstilbestrol (DES, in which one of the 4-hydroxyphenyl moieties was replaced by a ferrocenyl group, the McMurry reaction of chloropropionylferrocene with a number of mono-aryl ketones unexpectedly yielded the hydroxylated ferrocenyl DES derivatives, 5a–c, in poor yields (10%–16%. These compounds showed high activity on the hormone-independent breast cancer cell line MDA-MB-231 with IC50 values ranging from 0.14 to 0.36 µM. Surprisingly, non-hydroxylated ferrocenyl DES, 4, showed only an IC50 value of 1.14 µM, illustrating the importance of the hydroxyethyl function in this promising new series. For comparison, McMurry reactions of the shorter chain analogue chloroacetylferrocene were carried out to see the difference in behaviour with mono-aryl ketones versus a diaryl ketone. The effect of changing the length of the alkyl chain adjacent to the phenolic substituent of the hydroxylated ferrocenyl DES was studied, a mechanistic rationale to account for the unexpected products is proposed, and the antiproliferative activities of all of these compounds on MDA-MB-231 cells lines were measured and compared. X-ray crystal structures of cross-coupled products and of pinacol-pinacolone rearrangements are reported.

  11. Thiol-ene Monolithic Pepsin Microreactor with a 3D-Printed Interface for Efficient UPLC-MS Peptide Mapping Analyses

    DEFF Research Database (Denmark)

    Jönsson, Alexander; Svejdal, Rasmus R; Bøgelund, Nanna

    2017-01-01

    To improve the sample handling, and reduce cost and preparation time, of peptide mapping LC-MS workflows in protein analytical research, we here investigate the possibility of replacing conventional enzymatic digestion methods with a polymer microfluidic chip based enzyme reactor. Off-stoichiomet...... used in LC-MS based protein analyses. The chip IMER is found to rival the conventional column in terms of digestion efficiency at comparable residence time and, using a 3D-printed interface, be directly interfaceable with LC-MS.......To improve the sample handling, and reduce cost and preparation time, of peptide mapping LC-MS workflows in protein analytical research, we here investigate the possibility of replacing conventional enzymatic digestion methods with a polymer microfluidic chip based enzyme reactor. Off...

  12. 1α,6β,7β,11α,15β-Pentahydroxy-7α,20-epoxy-ent-kaur-16-ene

    Directory of Open Access Journals (Sweden)

    Chuang Feng

    2010-02-01

    Full Text Available The title compound, C20H30O6, a natural ent-kaurane diterpenoid, named nervosanin B, was obtained from the medicinal plant Isodon serra. It is composed of four rings with the expected trans and cis junctions. One of the six-membered rings is in a chair conformation, the other two are in boat conformations and the five-membered ring adopts an evenlope conformation. The molecules stack along the a axis and are linked together by intermolecular O—H...O hydrogen bonds. Two intramolecular O—H...O interactions also occur.

  13. 15α,20β-Dihydroxy-6β-methoxy-6,7-seco-6,20-epoxy-1,7-olide-ent-kaur-16-ene

    Directory of Open Access Journals (Sweden)

    Fu-Lin Yan

    2010-04-01

    Full Text Available The title compound, C21H30O6, a natural ent-kaurane diterpenoid, was obtained from the medicinal plant Isodon serra. The five rings in the molecule exhibit the expected cis and trans junctions. The three six-membered rings adopt chair, twist-boat and boat conformations, while two five-membered rings adopt envelope conformations. There are two molecules in the asymmetric unit, related by a non-crystallographic twofold screw axis; the main difference is in the different degrees of distortion of ring B. In the crystal, the molecules are linked by intermolecular O—H...O hydrogen bonds, forming chains along the b axis.

  14. 6β-Acetoxy-1α,7β,11β,15β-tetrahydroxy-7α,20-epoxy-ent-kaur-16-ene

    Directory of Open Access Journals (Sweden)

    Fu-Lin Yan

    2010-02-01

    Full Text Available The title compound, C22H32O7, a natural ent-kaurane diterpenoid also referred to as Maoyecrystal F, was obtained from the medicinal plant Isodon nervosa. There are four rings with the expected cis and trans junctions. Cyclohexane ring A adopts a chair conformation, rings B and C adopt boat conformations, while the five-membered ring has an envelope conformation. The molecules stack along the a axis in the crystal and are linked together by intermolecular O—H...O hydrogen bonds.

  15. Dimeric cyanobacterial cyclopent-4-ene-1,3-dione as selective inhibitor of Gram-positive bacteria growth: Bio-production approach and preparative isolation by HPCCC

    Czech Academy of Sciences Publication Activity Database

    Cheel, José; Bogdanová, K.; Ignatova, S.; Garrard, I.; Hewitson, P.; Kolář, M.; Kopecký, Jiří; Hrouzek, Pavel; Vacek, J.

    2016-01-01

    Roč. 18, SEP (2016), s. 244-249 ISSN 2211-9264 R&D Projects: GA MŠk EE2.3.30.0059; GA MŠk ED2.1.00/03.0110; GA MŠk(CZ) LO1416 Institutional support: RVO:61388971 Keywords : Phenolic cyclopentenedione * Natural antibiotic * Cyanobacteria Subject RIV: EE - Microbiology, Virology Impact factor: 3.994, year: 2016

  16. Riigi ülesannete täitmine lennuliiklusteeninduse korraldamisel : [bakalaureusetöö] / Imre Ernits ; Tartu Ülikool, õigusteaduskond ; juhendaja: Ene Andresen

    Index Scriptorium Estoniae

    Ernits, Imre

    2010-01-01

    Lennuohutuse tagamise funktsioonidest ja sellest tulenevatest riiklikest ülesannetest, Euroopa Liidu ja rahvusvahelisest õigusest tulenevatest nõuetest lennuliiklusteeninduse korraldamisele. Lennuliiklusteeninduse korraldusest Eesti õiguses, põhiseaduslikest probleemidest

  17. (E-2,2′-[3-(2-Nitrophenylprop-2-ene-1,1-diyl]bis(3-hydroxycyclohex-2-en-1-one

    Directory of Open Access Journals (Sweden)

    Joo Hwan Cha

    2012-01-01

    Full Text Available In the title compound, C21H21NO6, each of the cyclohexenone rings adopts a half-chair conformation. Each of the pairs of hydroxy and carbonyl O atoms are oriented to allow for the formation of intramolecular O—H...O hydrogen bonds, which are typical of xanthene derivatives.

  18. Vahistatute võrdne kohtlemine Eesti vanglates ja arestimajades : [magistritöö] / Sigrid Nurm ; Tartu Ülikool, õigusteaduskond ; juhendajad: Ene Andresen, Berit Aaviksoo

    Index Scriptorium Estoniae

    Nurm, Sigrid, 1988-

    2013-01-01

    Võrdse kohtlemise põhiõigusest, kinnipidamistingimustest ja riietusest, keelatud esemetest, kambrivälisest tegevusest, massiteabevahendite kättesaadavusest, kinnipidamisasutuse välisest suhtlemisest, ettepanekutest ebavõrdse kohtlemise kõrvaldamiseks

  19. Tavakoolide õpetajate suhtumine kõigi laste koosõpetamisse ja nende oskused erivajadustega laste õpetamisel tavaklassis / Ene Mägi, Aina Haljaste

    Index Scriptorium Estoniae

    Mägi, Ene, 1939-

    2001-01-01

    1998/99. õa. Eesti tavakoolides töötavate õpetajate seas läbi viidud küsitlusest: milline on õpetajate suhtumine kõigi laste koosõpetamisse ning missugused on õpetajate oskused ja vajadused erivajadustega laste õpetamisel tavaklassis

  20. Eesti pensionisüsteem Euroopa Liidu ühiste pensionimärkide valguses / Lauri Leppik, Ene-Margit Tiit, Andres Võrk

    Index Scriptorium Estoniae

    Leppik, Lauri, 1964-

    2004-01-01

    Eesti pensionisüsteemi probleemid on senistest liikmesriikidest erinevad: pensionisüsteemi jätkusuutlikkus on hea ja pensionäride vaesusrisk ei ole kõrge, kuid asendusmäär on suhteliselt madal. See tähendab, et ei suudeta tagada EL-i pensionieesmärki, mis taotleb, et inimesel oleks pensionile jäädes võimalk säilitada oma varasem elatustase. Diagramm. Tabelid. Graafikud

  1. Riigivastutus ilma riigi vastutuseta : notari, kohtutäituri ja vandetõlgi isiklik ametivastutus Euroopa õiguse ja riigiõiguse vaatepunktist / Ene Andresen

    Index Scriptorium Estoniae

    Andresen, Ene, 1977-

    2006-01-01

    Kas ja millistel tingimustel võib riik asendada oma vastutuse füüsilisest isikust avaliku võimu kandja vastutusega ning kuivõrd see on notari, kohtutäituri ja vandetõlgi puhul sisuliselt põhjendatud. Artikkel on valminud Eesti Teadusfondi grandilepingu nr. GOIAO6464 alusel finantseeritud uurimistöö raames

  2. Pakkujate võrdne kohtlemine riigihankemenetlusest kõrvaldamisel ja pakkujate kvalifitseerimisel : [magistritöö] / Piia Kulm ; Tartu Ülikool, õigusteaduskond ; juhendajad: Ene Andresen, Veiko Vaske

    Index Scriptorium Estoniae

    Kulm, Piia

    2009-01-01

    Võrdse kohtlemise põhimõtte sisust ja kohaldamisest ning selle põhimõtte järgimise tagamisest riigihangete õiguses, pakkujate kõrvaldamise ja pakkujate kvalifitseerimise etapi erinevustest, pakkujate hankemenetlusest kõrvaldamise ning kvalifitseerimise etapist

  3. 40-Godišnjica institucije Cambridge Crystallographic Data Centre posvećene pohranjivanju podataka o molekularnim i kristalnim strukturama -

    Directory of Open Access Journals (Sweden)

    Molčanov, K.

    2006-06-01

    Full Text Available The article is dedicated to 40th anniversary of The Cambridge Crystallographic Data Centre (CCDC, the world-known centre (http://www.ccdc.cam.ac.uk responsible for deposition and control of crystallographic data, including atomic coordinates that define the three-dimensional structures of organic molecules and metal complexes containing organic ligands. Cambride Structural Database (CSD, one among the first established electronic databases, nowadays is the most significant crystallographic database in the world. CSD has about 400,000 deposited structures. The use of the extensive database, which is growing rapidly, needs support of efficient and sophisticated software for searching, analysing and visualising structural data. The seminal role of CSD in the research related to crystallography, chemistry, material sciences, solid state physics and chemistry, life sciences, pharmacology, and in particular in drug design, has been documented in more than 1300 scientific papers. The important issues of CCDC are the accuracy of deposited data and development of software that enables a wide variety of applications. Such demanding project requires higly competent team of experts; thus the article brings into focus the scientific approach of the team based on the long tradition in crystallography, modelling and informatics. The article is not dedicated to 40th anniversary of the centre only, but it also reveals how Cambridge Structural Database can be used in the research and teaching. The use of electronic media and computer graphics makes “data mining" very efficient and useful but also esthetically appealing due to the molecular architecture. At the Rudjer Bošković Institute, Zagreb, Croatia there is The National Affiliated Centre of Cambridge Crystallographic Data Centre responsible for communication and dissemination of CSD in Croatia, Slovenia and Macedonia. The use of CSD is illustrated by two examples performed and published by the presenting authors: a the analysis of the less-common hydrogen bonds with the ester oxygen atom as a proton acceptor, and b topological analysis of tubular assemblies of macrocyclic polythianes extensively described in the references 24 and 28.

  4. Microcellular open porous monoliths for cell growth by thiol-ene polymerization of low-toxicity monomers in high internal phase emulsions

    Czech Academy of Sciences Publication Activity Database

    Sušec, M.; Liska, R.; Russmüller, G.; Kotek, Jiří; Krajnc, P.

    2015-01-01

    Roč. 15, č. 2 (2015), s. 253-261 ISSN 1616-5187 Institutional support: RVO:61389013 Keywords : divinyl adipate * polyHIPE * porous polymers Subject RIV: CD - Macromolecular Chemistry Impact factor: 3.680, year: 2015

  5. Stereochemistry of the epoxidation of bicyclo[2.2.1]hept-2-ene and its 7-syn-substituted derivatives. A DFT study

    Directory of Open Access Journals (Sweden)

    Sergiy I. Okovytyy

    2014-12-01

    Full Text Available The stereochemical aspects of epoxidation of norbornene and its 7-syn-substituted derivatives by performic acid were investigated. Geometry and thermodynamic parameters of transition states and prereactive complexes were computed at the UBHandHLYP/6-31G(d level of theory. It is shown that the transition states have a pronounced biradical character and a nearly coplanar orientation of the C=C bond and the molecule of performic acid. Transition state analysis revealed that, in the case of the syn-7-hydroxy derivative, the preference for the exo-approach of the oxidant can be explained by the stabilization of transition state with hydrogen bonding. In contrast, a chlorine atom or a methyl group at the 7-syn position facilitated the formation of endo-epoxides due to steric repulsion between the substituent and the oxidant.

  6. Electromagnetic Actuators.

    Science.gov (United States)

    1981-01-01

    CONSIDERATIONS The maximum allowable displacement is a function of the spring mec ).a- nism and the initial air qap between the base and the armature. For the...8217 U-) 10 II L jr-I 0 & ~ ~A2 0 . I w~L oc 0047 I ~ ~ ~ E~W-Ga7- 2075i--YYY-: oi a~ I I - LEI 2 :1; r- zf z3 l:2 ri ii48 fibi ism

  7. CAPHIGAS Project: Design of a Novel WGS-Adsorbent-Membrane Hybrid System for the Simultaneous Capture of CO{sub 2} and Production of H2 (Ref.: Ene2009-08002); Proyecto CAPHIGAS: Diseno de un Sistema Hibrido WGS-Adsorbente-Membrana para la Captura de CO{sub 2} con Produccion de H{sub 2} (Ref: Ene2009-08002)

    Energy Technology Data Exchange (ETDEWEB)

    Marano, M.; Barreiro, M. M.; Sanchez, J. M.

    2014-02-01

    This report describes the general objective, tasks and main results and conclusions drawn within CAPHIGAS Project, Plan Nacional de I+D+I 2008-2011, financed by the Spanish Ministry of Science and Innovation and carried out by the Valorization of Fuels and Wastes Group of Ciemat. The general objective of the project was the design and development of a novel hybrid system for the simultaneous removal of CO{sub 2} and production of H{sub 2} using a WGS catalyst-adsorbent membrane configuration. The novel system proposed has provided new insight into the adsorption and reaction processes and has allowed an optimization of the operating conditions to take advantage of the synergies between both processes. In this report main future activities are also reported. (Author)

  8. "Få frem x-ene på en måte, få frem svaret på x-ene": en studie av fire 7.trinnelevers arbeid med likninger, men fokus på strategier, likhetstegn og variabler

    OpenAIRE

    Lie, Liv-Iren

    2017-01-01

    Hensikten med denne oppgaven var å få et innblikk i hvordan noen elever i syvendeklasse jobber med likninger. Jeg ønsket å undersøke hvilke strategier elevene benytter seg av for å løse likningene, samt undersøke elevenes syn på likhetstegnet og oppfattelse av variabler. Det var også ønskelig å se om de to siste aspektene kunne ha noen innvirkning på strategiene elevene benyttet seg av. Forskningsspørsmålet i oppgaven er derfor som følger: 1. Hvilke strategier bruker fire sjuendeklassing...

  9. (4S)-4-(3,4-Dichloro?phen?yl)-1?-methyl-4?-phenyl-3,4-dihydronaphthalene-2-spiro-3?-pyrrolidine-2?-spiro-1??-acenaphthyl?ene-1,2??(2H,1??H)-dione

    OpenAIRE

    Murugan, R.; Gunasekaran, B.; Narayanan, S. Sriman; Manivannan, V.

    2008-01-01

    In the title compound, C37H27Cl2NO2, the 3,4-dichloro?phenyl ring makes a dihedral angle of 46.66?(6)? with the phenyl ring. The mol?ecular structure is stabilized by weak intra?molecular C?H?O inter?actions and the crystal structure is stabilized by weak inter?molecular C?H?O inter?actions. The C?C?C?C?C five-membered ring is planar, while the C?C?C?C?N five-membered ring adopts a half-chair conformation.

  10. C60 and Sc3N@C80(TMB-PPO) derivatives as constituents of singlet oxygen generating, thiol-ene polymer nanocomposites

    OpenAIRE

    Ashli R. Toles; Janice Paige Buchanan; Kyle A. Guess; Emily M. Barker

    2016-01-01

    Numerous functionalization methods have been employed to increase the solubility, and therefore, the processability of fullerenes in composite structures, and of these radical addition reactions continue to be an important methodology. C60 and Sc3N@C80 derivatives were prepared via radical addition of the photodecomposition products from the commercial photoinitiator TMB-PPO, yielding C60(TMB-PPO)5 and Sc3N@C80(TMB-PPO)3 as preferred soluble derivatives obtained in high yields. Characterizati...

  11. The Rearrangement of 1-Methylcyclohex-1-ene during the Hydrodesulfurization of FCC Gasoline over Supported Co(Ni)Mo/Al2O3 Sulfide Catalysts: the Isolation and Identification of Branched Cyclic C7 Olefins

    Czech Academy of Sciences Publication Activity Database

    Žáček, Petr; Kaluža, Luděk; Karban, Jindřich; Storch, Jan; Sýkora, Jan

    2014-01-01

    Roč. 112, č. 2 (2014), s. 335-346 ISSN 1878-5190 R&D Projects: GA ČR GAP106/11/0902 Institutional support: RVO:67985858 ; RVO:61388963 Keywords : hydrodesulfurization * olefin hydrogenation * branched cyclic olefins Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.170, year: 2014

  12. Effect of Promotion Metals on the Activity of MoS2/ZrO2 Catalyst in the Parallel Hydrodesulfurization of 1-Benzothiophene and Hydrogenation of 1-Methyl-Cyclohex-1-ene.

    Czech Academy of Sciences Publication Activity Database

    Kaluža, Luděk; Gulková, Daniela

    2016-01-01

    Roč. 118, č. 1 (2016), s. 313-324 ISSN 1878-5190 R&D Projects: GA ČR GAP106/11/0902 Institutional support: RVO:67985858 Keywords : hydrodesulfurization * hydrogenation * support effect Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 1.264, year: 2016

  13. Stereoselective synthesis of (2S,3S,4Z-4-fluoro-1,3-dihydroxy-2-(octadecanoylaminooctadec-4-ene, [(Z-4-fluoroceramide], and its phase behavior at the air/water interface

    Directory of Open Access Journals (Sweden)

    2008-04-01

    Full Text Available BackgroundSphingolipids belong to the most important constituents of the membranes of eukaryotic cells. As intermediates in sphingolipid metabolism, sphingosine and its N-octadecanoyl-derivative, ceramide, exhibit a variety of biological functions. These compounds play a crucial role in many essential biological processes such as cell growth, cell differentiation, cell recognition and apoptosis. More specifically, sphingolipids are crucial e.g. for the function of the skin because they contribute to the formation of the water permeability barrier consisting of a highly organized multilaminar lipid matrix of free fatty acids, cholesterol and ceramides containing additional hydroxyl groups in the sphingosin part and longer fatty acid amide functions.ResultsIn a short synthetic route (2S,3S-4-fluorosphingosine and 4-fluoroceramide, the fluorinated analogues of the natural products, D-erythro-sphingosine and ceramide, have been prepared. The key step of the synthetic sequence is an asymmetric aldol reaction of (Z-2-fluorohexadec-2-enal, prepared in three steps from tetradecanal, with an enantiopure N-protected iminoglycinate. Deprotection of the imino function and reduction of the ester group led to the 4-fluorosphingosine, which on acetylation with stearoyl chloride gave 4-fluoroceramide. After careful HPLC purification of the latter compound its phase behavior was investigated by Langmuir film balance technique and compared to that of natural ceramide. While the isotherms are quite similar in shape, they differ significantly in the starting point of increasing film pressure (56 or 67 Å2/molecule and in the film collapse pressure (38 or 56 mN/m for ceramide and 4-fluoroceramide, respectively. Moreover, the hysteresis curves are very different. While consecutive isothermic compression – expansion cycles are reversible for the 4-fluoro derivative, substantial substance loss into the subphase or irreversible formation of multi-layers was observed for natural ceramide.ConclusionsAsymmetric aldol reaction proved to be successful for the preparation of enantiopure 4-fluoroceramide. Surface/pressure isotherms and hysteresis curves of ceramide and its 4-fluoro derivative showed that the presence of fluorine leads to stronger intermolecular interactions between the hydrophobic chains of neighboring molecules, and therefore to increasing stability of the monolayer of 4-fluoroceramide at the air water interface.

  14. IR Laser-Induced Thermolysis of Silacyclopent-3-ene: Extru sion of Silylene and Chemical Vapour Deposition of Polycarb osilane Phases Via Reactions of Silylene, Buta-1,3-Diene a nd Methylene

    Czech Academy of Sciences Publication Activity Database

    Pola, Josef; Urbanová, Markéta; Díaz, L.; Santos, M.; Bastl, Zdeněk; Šubrt, Jan

    2000-01-01

    Roč. 605, - (2000), s. 202-208 ISSN 0022-328X R&D Projects: GA ČR GA104/00/1294 Grant - others:DGES(ES) PB96-0844-C02-02 Subject RIV: CH - Nuclear ; Quantum Chemistry Impact factor: 1.632, year: 2000

  15. CAPHIGAS Project: Design of a Novel WGS-Adsorbent-Membrane Hybrid System for the Simultaneous Capture of CO2 and Production of H2 (Ref.: Ene2009-08002)

    International Nuclear Information System (INIS)

    Marano, M.; Barreiro, M. M.; Sanchez, J. M.

    2014-01-01

    This report describes the general objective, tasks and main results and conclusions drawn within CAPHIGAS Project, Plan Nacional de I+D+I 2008-2011, financed by the Spanish Ministry of Science and Innovation and carried out by the Valorization of Fuels and Wastes Group of Ciemat. The general objective of the project was the design and development of a novel hybrid system for the simultaneous removal of CO 2 and production of H 2 using a WGS catalyst-adsorbent membrane configuration. The novel system proposed has provided new insight into the adsorption and reaction processes and has allowed an optimization of the operating conditions to take advantage of the synergies between both processes. In this report main future activities are also reported. (Author)

  16. 4,5,7,8,17-Pentahydroxy-14,18-dimethyl-6-methylene-3,10-dioxapentacyclo[9.8.0.01,7.04,19.013,18]nonadec-14-ene-9,16-dione methanol solvate dihydrate

    Directory of Open Access Journals (Sweden)

    Chin Hoe Teh

    2009-04-01

    Full Text Available The title quassinoid compound, C20H24O9·CH3OH·2H2O, is a natural eurycomanone isolated from the roots of Eurycoma longifolia. The molecules contain a fused five-ring system, with one tetrahydrofuran ring adopting an envelope conformation, one tetrahydropyran-2-one ring in a screw boat conformation, one cyclohexenone ring in a half-chair conformation and two cyclohexane rings in chair conformations. Intramolecular C—H...O interactions generate S(5 ring motifs and an O—H...O interaction generates an S(7 ring motif. In the crystal, molecules are linked via intermolecular O—H...O interactions along the b axis and further stacked along a axis. The absolute configuration of the title compound was inferred from previously solved structures of its analogues.

  17. Rändeandmete kvaliteet ja rändesuundumused Eestis aastatel 2000-2005 = The quality of migration data and the trends of migration in Estonia in 2000-2005 / Alis Tammur, Tiit Tammaru, Ene- Margit Tiit

    Index Scriptorium Estoniae

    Tammur, Alis

    2006-01-01

    Eesti statistilise rahvastikuarvestuse alus on olnud viimase rahvaloenduse rahvaarv, millele lisatakse omavalitsusüksuste kaupa registripõhiselt kogutavad sünnid, surmad ning sisse- ja väljaränne. Rahvaloenduse ja rahvastikuregistri andmete põhimõtteline erinevus. Sise- ja välisrände arvestamise probleemid, rändesuundumuste analüüs. Diagramm. Tabelid

  18. Retos traductológicos EN>ES en la industria cinematográfica: la traducción de títulos de películas en España

    OpenAIRE

    Clavero Ramos, Mario Jesús

    2017-01-01

    TFG RECOMENDADO POR EL CENTRO. En un mundo globalizado como el actual, la traducción audiovisual está presente en la vida diaria de mucha gente. Todas las producciones cinematográficas cuentan con un título que resume su contenido y que puede o no ser adaptado a la lengua de llegada. Los títulos se han traducido siempre de diferentes maneras, por lo que se pueden analizar según sus técnicas de traducción. Mediante el análisis de estas técnicas de traducción de los títulos de película al españ...

  19. Lugupeetud Eesti Vabariigi president Arnold Rüütel, Riigikogu esimees Ene Ergma, peaminister Juhan Parts : avalik pöördumine unikaalse mälestise päästmiseks

    Index Scriptorium Estoniae

    2004-01-01

    Palutakse aidata kaasa Tallinna Lennusadamasse aastatel 1916-1917 püstitatud raudbetoonkoorikattega vesilennukiangaaride kui muinsuskaitseobjekti võimalikult kiirele restaureerimisele. Hoone ja selle komplekskoorikud projekteerisid-ehitasid Taani firma Christiani & Nielsen insenerid Sven Schultz, K. N. Höjgaard ja Herluf Forschhammer

  20. Eesti õiguse vastavus direktiivile 2003/109/EÜ pikaajalise elaniku staatuse saamist reguleerivate sätete osas : [magistritöö] / Maret Kruus ; Tartu Ülikool, õigusteaduskond ; juhendaja: Ene Andresen

    Index Scriptorium Estoniae

    Kruus, Maret

    2014-01-01

    Direktiivi 2003/109/EÜ ülevõtmise üldküsimustest, sisulistest tingimustest pikaajalise elaniku staatuse saamiseks, menetluslikest nõuetest pikaajalise elaniku staatuse saamiseks ja õiguskaitsega seonduvatest probleemidest

  1. Hiina tänapäeva arhitektuur - karmiilmeline, aga põnev / Zhang Ke, Zhang Hong, Xiaodu Liu ; interv. Hanna Läkk ja Ene Läkk

    Index Scriptorium Estoniae

    Zhang Ke

    2006-01-01

    Intervjuu Hiina arhitektuuribüroo Standardarchitecture arhitektide Zhang Ke ja Zhang Hongiga ning arhitektuuribüroo Urbanus arhitekti Xiaodu Liuga Hollandis Hiina tänapäeva tutvustaval näitusel. Hiina arhitektide haridusest, oma arhitektuuribüroode töödest, tänapäeva hiina arhitektuurist, põhiprobleemidest

  2. Increased Monoclonal Components: Prevalence in an Italian Population of 44 474 Outpatients Detected by Capillary Electrophoresis/ Povišene monoklonske komponente: prevalencija u skupini 44.474 italijanskih nehospitalizovanih ispitanika detektovana kapilarnom elektroforezom

    Directory of Open Access Journals (Sweden)

    Vernocchi Arialdo

    2016-01-01

    Full Text Available Uvod: Identifikacija, kvantifikacija i tipizacija M-proteina (MP imaju važnu ulogu u dijagnostikovanju, klasifikovanju i praćenju monoklonskih gamapatija kako malignog (npr. multipli mijelom tako i nepoznatog porekla. Prethodni dokazi pokazuju da monoklonska gamapatija neodređenog značaja (MGNZ koja se otkriva elektroforezom na agaroznom gelu ima prevalenciju od 3,2% u opštoj (populaciji. Stoga je cilj ove studije bio da verifikuje navedene podatke putem elektroforeze kapilarne zone.

  3. Seasonal Water Transport in the Atmosphere of Mars: Applications of a Mars General Circulation Model Using Mars Global Surveyor Data

    Science.gov (United States)

    Hollingsworth, Jeffery L.; Bridger, Alison F. C.; Haberle, Robert M.

    1999-01-01

    This is a Final Report for a Joint Research Interchange (JRI) between NASA Ames Research Center and San Jose State University, Department of Meteorology. We present below a summary of progress made during the duration of this JRI. The focus of this JRI has been to investigate seasonal water vapor transport in the atmosphere of Mars and its effects on the planet's present climate. To this end, the primary task has been to adapt a new dynamical processor for the adiabatic tendencies of the atmospheric circulation into the NASA Ames Mars general circulation model (MGCM). Using identical boundary and initial conditions, several comparative tests between the new and old MGCMs have been performed and the nature of the simulated circulations have been diagnosed. With confidence that the updated version of the Ames MGCM produces quite similar mean and eddy circulation statistics, the new climate model is well poised as a tool to pursue fundamental questions related to the spatial and seasonal variations of atmospheric water vapor on Mars, and to explore exchanges of water with non-atmospheric reservoirs and transport within its atmosphere. In particular, the role of surface sources and sinks can be explored, the range of water-vapor saturation altitudes can be investigated, and plausible precipitation mechanisms can be studied, for a range of atmospheric dust loadings. Such future investigations can contribute to a comprehensive study of surface inventories, exchange mechanisms, and the relative importance of atmospheric transport Mars' water cycle. A listing of presentations made and manuscripts submitted during the course of this project is provided.

  4. Upgrading of Gasification Gases by means of a Catalytic Membrane Reactor: WGS Catalysts and Inorganic Palladium Membranes HENRECA Project (ENE2004-07758-CO2-01). Final Report; Estudios de Enriquecimiento en H{sub 2} de Gases de Gasificacion mediante el Uso Reactor Catalitico de Membranas: Catalizadores WGS y Membranas Inorganicas de Paladio. Informe Final Proyecto HENRECA (ENE2004-07758-C02-01)

    Energy Technology Data Exchange (ETDEWEB)

    Maranon Bujan, M.; Sanchez Hervas, J. M.; Barreiro Carou, M. del

    2008-07-01

    The combination of a CO catalytic converter with a highly hydrogen selective membrane out stands as a very promising technology for the upgrading of biomass gasification gases. The advantages of this combined system over the traditional two stages WGS technology has been investigated within the HENRECA project, financed under the Spanish PN 2004-2007 of the Ministry of Science and Technology. This project started in September 2004 and had a duration of three years. The Division of Combustion and Gasification of CIEMAT participates in this project in three main activities: the study of the catalytic activity of WGS catalysts synthesised by the other partner of the project (University Rey Juan Carlos), the design of the reaction-separation system and the design and construction of a bench-scale pilot plant where the performance of the membranes prepared by URJC and the catalytic membrane system were investigated. This report describes the activities carried out within the project and the main results obtained. (Author) 14 ref.

  5. Methodological guide for communities greenhouse gas emission assessments according to the article 75 of the 2010-788 law of July 12, 2010 bearing national commitment for the environment (ENE); Guide methodologique pour la realisation des bilans d'emissions de gaz a effet de serre des collectivites conformement a l'article 75 de la loi n. 2010-788 du 12 juillet 2010 portant engagement national pour l'environnement (ENE)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    After some basic definitions, this document describes the approach chosen to count greenhouse gas emissions as they are defined in the law: identification of emissions to be counted in greenhouse gas emission assessments, wider framework of district climate-energy plans. It describes how the general methodology is implemented, and more particularly in the case of a district or community. One can find in appendix: the strategic framework for regional climate air and energy scheme, a list of possible methodological principles within the frame of a district approach, and the case of emissions related to waste processing and of associated avoided emissions

  6. Method for greenhouse gas emission assessments according to the article 75 of the 2010-788 law of July 12, 2010 bearing national commitment for the environment (ENE); Methode pour la realisation des bilans d'emissions de Gaz a effet de serre conformement a l'article 75 de la loi n. 2010-788 du 12 juillet 2010 portant engagement national pour l'environnement (ENE)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    This document presents mandatory methodological principles, optional prescriptions and optional recommendations for the assessment of greenhouse gas emissions. After having recalled some basic definitions, and regulatory arrangements and performance principles for greenhouse gas emission assessment, this document proposes a diagram indicating the main steps of such an assessment. It defines the organisational frame (for companies or communities), presents the concept of operational perimeter. It reviews the general principles of the assessment: global approach and priorities, calculation with respect to measurement, emission factors, gas global warming potential, reporting and reference year, uncertainty management, case of electricity, case of biomass CO{sub 2}, cogeneration and electricity production from renewable energy, compensation. It presents the reporting format. Some aspects are more precisely presented or described in appendix

  7. Eesti teater välismaal : gastrollid ja saavutused aastal 2004 / Mari Kolle, Katrin Talts

    Index Scriptorium Estoniae

    Kolle, Mari

    2004-01-01

    Veebruaris andis Londoni Teatriühing balletipaarile A. Oks-T. Edur Briti teatripreemia, Laurence Olivier teatriauhinna; VAT Teatri lavastus "Kivid" hinnati Peterburi rahvusvahelisel noorsooteatrite festivalil "Vikerkaar" preemiaga "Parim lavastus väikesel laval"; Vanemuise lavastus "Roberto Zucco" võitis Poolas teatrifestivalil "Kontakt" II peaauhinna ja nimiosatäitja T. Tuisk parima noore näitleja auhinna; Von Krahli Teater võitis lavastusega "Luikede järv" New Yorgi Bessie-auhinna ; Jaapani rahvusvahelisel teatrifestivalil pälvis lavastaja J. Urvet parima meesnäitleja preemia osatäitmise eest "Niagaaras"; rahvusvaheliselt äratas tähelepanu eesti-soome ühistööna kirjutatud näidend "Taksojuhid", mille autorid on M. Ulman ja J. Niilekselä. Kaasaegse tantsu vallas olid rahvusvaheliste festivalide favoriidid M. Kangro, K. Essenson ja R. Keerd

  8. An Intercomparison of the Dynamical Cores of Global Atmospheric Circulation Models for Mars

    Science.gov (United States)

    Hollingsworth, Jeffery L.; Bridger, Alison F. C.; Haberle, Robert M.

    1998-01-01

    This is a Final Report for a Joint Research Interchange (JRI) between NASA Ames Research Center and San Jose State University, Department of Meteorology. The focus of this JRI has been to evaluate the dynamical 'cores' of two global atmospheric circulation models for Mars that are in operation at the NASA Ames Research Center. The two global circulation models in use are fundamentally different: one uses spherical harmonics in its horizontal representation of field variables; the other uses finite differences on a uniform longitude-latitude grid. Several simulations have been conducted to assess how the dynamical processors of each of these circulation models perform using identical 'simple physics' parameterizations. A variety of climate statistics (e.g., time-mean flows and eddy fields) have been compared for realistic solstitial mean basic states. Results of this research have demonstrated that the two Mars circulation models with completely different spatial representations and discretizations produce rather similar circulation statistics for first-order meteorological fields, suggestive of a tendency for convergence of numerical solutions. Second and higher-order fields can, however, vary significantly between the two models.

  9. Ostame maja! / Kersti Pikk, Aet Piel, Piret Tali

    Index Scriptorium Estoniae

    Pikk, Kersti

    2007-01-01

    Võrreldakse kolme eramut - Pirital, Viimsis (Arhitektuuriagentuur OÜ - arhitektid Inga Raukas, Toomas Tammis, Karli Luik ja Renee Puusepp) ja Harku vallas Vatslas. Lk. Oberhausi kinnisvaraspetsialisti Ene Arro kommentaar

  10. Jan Gehli teose "Linnad inimestele" ilmumine = Publication of an Estonian-language Edition of Jan Gehl's Cities for People / Yoko Alender, Liina Teder, Neeme Lopp

    Index Scriptorium Estoniae

    Alender, Yoko, 1979-

    2016-01-01

    Taani arhitektist Jan Gehlist ja tema raamatust "Linnad inimestele". Eestikeelse väljaande toimkond: Yoko Alender, Neeme Lopp, Liina Teder, Eneli Rohtla. Maastikuarhitektuuri aastapreemia nominent 2016

  11. Prague quadrennial 14.06-20.06/2007. Short play: crisis of forties flood after rain/ Vladimir Anshon

    Index Scriptorium Estoniae

    Anšon, Vladimir, 1963-

    2010-01-01

    XI rahvusvahelisest Praha lavastuskunstnike kvadriennaalist (Prague Quadrennial). Eesti rahvuslikust väljapanekust, kuraator Ene-Liis Semper ja Eesti Kunstiakadeemia väljapanekust, kuraator Lilja Blumenfeld

  12. Eesti keel eestlaste emotsioonidest / Haldur Õim

    Index Scriptorium Estoniae

    Õim, Haldur, 1942-

    2004-01-01

    Arvustus: Vainik, Ene. Lexical knowledge of emotions: the structure, variability and semantics of the Estonian emotion vocabulary. Tartu : Tartu University Press, 2004. (Dissertationes linguisticae Universitatis Tartuensis ; 5)

  13. Agenda kultuuripealinna ArtGendast / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    1998-01-01

    24. maini Stockholmi Kulturhusetis avatud Balti mere maade noortebiennaalist 'ArtGenda'. Peakorraldaja Beate Sydhoff. Eestlaste - Ene-Liis Semper, Martin Pedanik, Andrus Kõresaar, Marko Laimre - esinemisest.

  14. Inert Reassessment Document for Poly(oxyethylene) adducts of mixed phytosterols

    Science.gov (United States)

    Poly(oxyethy1ene) adducts of mixed phytosterols is uncategorized as to list classification status. Based upon the reasonable certainty of no harm safety finding, the List 4B classification for poly(oxyethy1ene) adducts of mixed phytosterols is affirmed.

  15. Prepositional Intraference in ESL and Its Teaching: The Educated Nigerian English Examples

    Science.gov (United States)

    Ekundayo, Omowumi Steve Bode

    2014-01-01

    This paper examines the linguistic habit of "prepositional intraference" in Educated Nigerian English (ENE) with a view to establishing why and how Nigerians produce prepositional intraference variations and how the variations distinguish ENE morphosyntax from native English morphosyntax, particularly Standard British English (SBE).…

  16. Kontserdisari kutsub "Klavessiinisalongi"

    Index Scriptorium Estoniae

    2008-01-01

    Rakvere Kaurikooli saalis toimuvatest kontsertidest: 7. dets."iViva Espagna!" (esinevad klavessiiniduo Ene Nael - Kristiina Are ja näitleja Tarmo Song), 15. veebr. "Häälemeelne" (laulja Kelli Pärnaste ja kitarrist Tiit Korsar, klavessinist Ene Nael) ja 26. apr. "Fiori musicali" (Tallinna Vanalinna Hariduskolleegiumi, Tallinna Muusikakeskkooli ja Rakvere Kaurikooli klavessiiniõpilased)

  17. Emotional (non)-expression and health : Data, questions, and challenges

    NARCIS (Netherlands)

    Nyklicek, I.; Vingerhoets, A.J.J.M.; Denollet, J.K.L.

    2002-01-01

    The available evidence on the relationship between expression and non-expression of emotions (E/NE) and health is selectively and critically reviewed. It is concluded that research in this field still lacks conceptual lucidity with regard to the many existing E/NE concepts. Despite the fact that few

  18. Nasha "Russkaja galereja" v Madride

    Index Scriptorium Estoniae

    2005-01-01

    Kaasaegse kunsti laat ARCO Madridis. Osaleb "Vene galerii" Tallinnast näitusega TRINITY. Galerist Masha Melnikova. Osalevad Ene-Liis Semper ja Moskva kunstnikud Anton Litvin ning Bogdan Mamonov. Ene-Liis Semper näitab videokunsti, Anton Litvin fotoprojekti ja Bogdan Mamonov realistlikke portreid. Näitus märtsis Vene saatkonna galeriis Tallinnas

  19. New aspects on the chemotaxonomy of Phytolacca dodecandra with regard to the isolation of phytolaccagenin, phytolaccagenic acid and their glycosides.

    Science.gov (United States)

    Spengel, S M; Luterbacher, S; Schaffner, W

    1995-08-01

    In leaves, roots and calli of P. dodecandra we found two 28,30-dicarboxyolean-12-enes and their glycosides in addition to the hitherto known four 28-monocarboxyolean-12-enes on which the chemotaxonomy was based. Therefore, P. dodecandra can no longer be considered as chemotaxonomically different from the other Phytolacca species.

  20. Crystal structure of an unknown solvate of bis­(tetra-n-butyl­ammonium) [N,N′-(4-tri­fluoro­methyl-1,2-phenyl­ene)bis­(oxamato)-κ4 O,N,N′,O′]nickelate(II)

    Science.gov (United States)

    Eya’ane Meva, François; Schaarschmidt, Dieter; Rüffer, Tobias

    2015-01-01

    In the title compound, [N(C4H9)4]2[Ni(C11H3F3N2O6)] or [N(n-Bu)4]2[Ni(topbo)] [n-Bu = n-butyl and topbo = 4-tri­fluoro­methyl-1,2-phenyl­enebis(oxamate)], the Ni2+ cation is coordinated by two deprotonated amido N atoms and two carboxyl­ate O atoms, setting up a slightly distorted square-planar coordination environment. The [Ni(topbo]2− anion lies on a twofold rotation axis. Due to an incompatibility with the point-group symmetry of the complete mol­ecule, orientational disorder of the CF3 group is observed. The tetra­hedral ammonium cations and the anion are linked by weak inter­molecular C—H⋯O and C—H⋯F hydrogen-bonding inter­actions into a three-dimensional network. A region of electron density was treated with the SQUEEZE procedure in PLATON [Spek (2015). Acta Cryst. C71, 9–18] following unsuccessful attempts to model it as plausible solvent mol­ecule(s). The given chemical formula and other crystal data do not take into account the unknown solvent mol­ecule. PMID:26090126

  1. Synthesis, crystal structure, and H/D exchange of the inside protonated form of the cage imine 4,8,12-triaza-1-azoniatricyclo[6.6.3.2(4,12)]nonadec-1(15)-ene. A model for proton transfer through an aliphatic membrane

    DEFF Research Database (Denmark)

    Springborg, Johan; Nielsen, Bente; Olsen, Carl Erik

    2002-01-01

    , which gave K-im = 1.57(1) x 10(-5) M at 25 degreesC, DeltaSdegrees = -83(1) J mol(-1) K-1 and DeltaHdegrees = 2,6(3) kJ mol(-1) at 1 = 1.0 M (NaCl). The inside coordinated proton in 3 is labile in basic solution and the rate for NH/ND exchange was determined by H-1 NMR at three different temperatures....... The reaction followed the expression k(obs) = k(ex)[OD-] with k(ex) = 0.0978(30) dm(3) mol (1) s(-1) at 25 degreesC, DeltaSdegrees = 87(4) J mol(-1) K-1, and DeltaHdegrees = 104.9(11) kJ mol(-1) at I = 1.0 M (NaCl). The exchange rate is more than 5 x 106 times faster than that of the parent saturated cage 1...

  2. Spectral investigations, DFT computations and molecular docking studies of 1,7,8,9-tetrachloro-10,10-dimethoxy-4-{3-[4-(2-methylphenyl)piperazin-1-yl]propyl}-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

    Science.gov (United States)

    Resmi, K. S.; Mary, Y. Sheena; Varghese, Hema Tresa; Panicker, C. Yohannan; Pakosińska-Parys, Magdalena; Alsenoy, C. Van

    2015-10-01

    The optimized molecular structure, vibrational frequencies, corresponding vibrational assignments of the title compound have been investigated experimentally and theoretically. The HOMO and LUMO analysis is used to determine the charge transfer within the molecule. The stability of the molecule arising from hyper-conjugative interaction and charge delocalization has been analysed using NBO analysis. The hyperpolarisability calculation reveals the present material has a reasonably good propensity for nonlinear optical activity. Due to the different potential biological activity of the title compound, molecular docking study is also reported and the compound might exhibit inhibitory activity against human M2 muscarinic acetylcholine receptor.

  3. Characterization and inhibition studies of tissue nonspecific alkaline phosphatase by aminoalkanol derivatives of 1,7-dimethyl-8,9-diphenyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5,10-trione, new competitive and non-competitive inhibitors, by capillary electrophoresis.

    Science.gov (United States)

    Grodner, Błażej; Napiórkowska, Mariola

    2017-09-05

    The article describes the inhibitory effect of two new aminoalkanol derivatives on the enzymatic kinetic of tissue non-specific alkaline phosphatase with use of capillary zone electrophoresis to evaluate the inhibitory effect. This technique allows to investigate of the enzymatic kinetic by the measure of the amounts of the substrate and product in the presence of compound (I) or (II) in the reaction mixture. The separation process was conducted using an eCAP fused-silica capillary. The detector was set at 200nm. The best parameters for the analysis were: 25mM sodium dihydrogen phosphate adjusted to pH=2.5, temperature 25°C, and voltage -15kV. Lineweaver-Burk plots were constructed and determined by comparison of the Km, of alkaline phosphatase in the presence of inhibitor (I) or (II) with the Km in a solution without inhibitor. The influence of replacement the propylamine group by the dimethylamine group on tissue non-specific alkaline phosphatase inhibition activity of new derivatives (I) and (II) was investigated. The tested compounds (I) and (II) were found to be tissue non-specific alkaline phosphatase inhibitors. Detailed kinetic studies indicated a competitive mode of inhibition against tissue non-specific alkaline phosphatase for compound (I) and non-competitive mode of inhibition for compound (II). Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Synthesis, crystal structure, and H/D exchange of the inside protonated form of the cage imine 4,8,12-triaza-1-azoniatricyclo[6.6.3.2(4,12)]nonadec-1(15)-ene. A model for proton transfer through an aliphatic membrane

    DEFF Research Database (Denmark)

    Springborg, Johan; Nielsen, Bente; Olsen, Carl Erik

    2002-01-01

    belonging to the triazacyclononane entity. The imine double bond is situated between the N-atom of the triazacyclononane entity and the C-atom belonging to one of the three trimethylene bridges. The imine 2 is stable in acidic solution and the inside coordinated proton is very robust in acidic solution....... In basic solution the imine reacts fast to give a quantitative formation of the inside protonated form of the hemiaminal 1,4,8,12-tetraazatricyclo[6.6.3,2(4.12)]nonadecan-5-ol (3). The equilibrium constant K-im = [3][H+]/[2] was determined at three different temperatures from potentiometric measurements......, which gave K-im = 1.57(1) x 10(-5) M at 25 degreesC, DeltaSdegrees = -83(1) J mol(-1) K-1 and DeltaHdegrees = 2,6(3) kJ mol(-1) at 1 = 1.0 M (NaCl). The inside coordinated proton in 3 is labile in basic solution and the rate for NH/ND exchange was determined by H-1 NMR at three different temperatures...

  5. Incidence and risk factors of intraventricular hemorrhage in preterm newborns Evaluación de la incidencia y los factores de riesgo para hemorragia intraventricular (HIV en la cohorte de recién nacidos prematuros atendidos en la unidad neonatal del HUSVP, de Medellín, en el período comprendido entre ene. de 1999 y dic. de 2004

    Directory of Open Access Journals (Sweden)

    José William Cornejo Ochoa

    2007-12-01

    Full Text Available Introduction: intraventricular hemorrhage is the main neurological complication of preterm newborns. Its frequency and severity increase as gestational age and weight at birth decrease. Other factors have been described that may influence its incidence. Objective: to determine the incidence of intraventricular hemorrhage at the Neonatal Care Unit of the Hospital Universitario San Vicente de Paúl, in Medellín, Colombia, from 1999 to 2004, and to establish its association with maternal and newborn conditions. Results: an incidence of HIV of 29.8% was found. Cesarean section, labor in a third level attention center and pulmonary maturation were found to be protective factors. On the other hand, the incidence of HIV increased with the following circumstances: vaginal labor, gestational age under 28 weeks, use of surfactant, mechanical ventilation, acidosis, hypercapnia and umbilical catheterism. Conclusions: prenatal programs have to be reinforced in order to avoid preterm labor; high risk pregnant women ought to be opportunely referred to specialized centers; the antenatal use of steroids is to be encouraged and careful management of ventilatory parameters avoiding acidosis is mandatory. La hemorragia intraventricular (HIV es la principal complicación neurológica de los recién nacidos prematuros, cuyas frecuencia y gravedad aumentan con el menor peso al nacer y la menor edad gestacional. Se han encontrado otros factores asociados con el aumento o disminución de su frecuencia. Objetivo: determinar la incidencia de HIV en prematuros atendidos en el Hospital Universitario San Vicente de Paúl (HUSVP, de Medellín, Colombia, entre 1999 y 2004 y establecer su asociación con condiciones de la madre y del recién nacido. Metodología: estudio retrospectivo de los prematuros menores de 32 semanas y por debajo de 1.500 gramos, atendidos en el HUSVP entre 1999 y 2004. Se calculó una muestra de 330 historias clínicas, seleccionadas en forma aleatoria, con un nivel de confianza de 95%, error del 3% y poder del 80%,con base en una incidencia del 15% de HIV en la población general. Resultados: la incidencia encontrada de HIV fue 29,8%. Como factores protectores se encontraron los siguientes: parto por cesárea, parto en un centro de tercer nivel y maduración pulmonar. Como factores que aumentaron el riesgo de HIV se encontraron: parto vaginal, edad gestacional menor de 28 semanas, uso de surfactante, ventilación mecánica, cateterismo umbilical, acidosis e hipercapnia. Conclusiones: se debe insistir en la importancia de que haya programas adecuados de control prenatal para tratar de disminuir la frecuencia de parto prematuro, procurar la remisión oportuna de las gestantes de alto riesgo a centros de referencia, estimular el uso antenatal de esteroides y el control cuidadoso de los parámetros ventilatorios en los pacientes que requieran este soporte, buscando mantener un adecuado equilibrio ácido-base en los recién nacidos.

  6. C(18) acetylenic fatty acids of Ximenia americana with potential pesticidal activity.

    Science.gov (United States)

    Fatope, M O; Adoum, O A; Takeda, Y

    2000-05-01

    Bioactivity-driven fractionation of the CHCl(3) extract of the root of Ximenia americana, using the brine shrimp lethality test (BST) and hatchability test with Clavigralla tomentosicollis eggs, gave C(18) acetylenic fatty acids 1 and 2. 1 is octadeca-5-ynoic acid (tariric acid). 2 is a novel ene-ene-yne-ene acetylenic fatty acid (10Z,14E,16E-octadeca-10,14,16-triene-12-ynoi c acid). The structures of 1 and 2 were assigned from the MS and NMR data. Fractions that are rich in acetylenic fatty acids inhibited the hatching of C. tomentosicollis eggs.

  7. 2008. aastal keskenduti e-teenuste arendamisele : [2008. aasta rahvaraamatukogudes keskraamatukogude aruannete põhjal, tulevikuplaanides] / Meeli Veskus

    Index Scriptorium Estoniae

    Veskus, Meeli, 1953-

    2009-01-01

    Sisaldab ka: Raamatukogude kasutamine, lugejad ja kogud / Margit Jõgi. Lisa: Lugejateenindus ja kogud üldkasutatavates rahvaraamatukogudes 2008 : [joonised] / Margit Jõgi. Milline oli olukord rahvaraamatukogudes 2009. aasta algul? / Ene Riet.

  8. Disease: H00452 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ene) ... AUTHORS ... Hellemans J, Preobrazhenska O, Willaert A, Debeer P, Verdonk PC, Costa T, Janssens K, Men...ten B, Van Roy N, Vermeulen SJ, Savarirayan R, Van Hul W, Vanhoenacker F, Huylebroe

  9. Extra Strong Super Light / Magdalena Lewoc

    Index Scriptorium Estoniae

    Lewoc, Magdalena

    2003-01-01

    2003. a. Szczecini Rahvusmuuseumis toimunud 5. rahvusvahelisest kunstinäitusest võtsid osa poola, saksa, rootsi, soome, leedu, läti, ukraina ja eesti kunstnikud. Pikemalt Ene-Liis Semperi ja Jaan Toomiku loomingust

  10. Effect of acid corrosion on crack propagation of concrete beams

    Indian Academy of Sciences (India)

    HU SHAOWEI

    2018-03-10

    . ... forest, vegetation, lakes and soil have been recognized by common ..... the fictitious crack zone, and it is calculated by the soft- ening traction–separation law [20]. The stress intensity factor caused by cohesive force can be ...

  11. Publik istub varumängijate pingil / Ott Karulin

    Index Scriptorium Estoniae

    Karulin, Ott, 1980-

    2007-01-01

    Lava ja saali vahelise piiri lõhkumisest. Publiku kaasamisest etendustesse kolme lavastuse näitel: Mati Undi "Laulatus", Tiit Ojasoo ja Ene-Liis Semperi "Nafta" ja Sven Heibergi "Kuidas elad?...Ann?"

  12. Vanemuisel kolmas teatrilava

    Index Scriptorium Estoniae

    2001-01-01

    1. X Tartus avatavast Sadamateatrist. Projekteerija: AS Tari. Projektijuht Toomas Jõgeva, sisekujundaja Aivar Roosaar. 1. X Virginia Woolfi "Orlando", Ene-Liis Semperi ja Kristel Leesmendi lavastajadebüüt. 1. okt. avatakse black-box

  13. Kaks uut 'Kalevipoega' / Wello Uuskyla ; Juss Piho illustratsioonid

    Index Scriptorium Estoniae

    Uuskyla, Wello

    1998-01-01

    Arvustus: Kalevi kange poeg / koost. Ene Kenkmaa ; ill. Juss Piho. Tallinn : RE Stuudio, 1995 ; Kreutzwald, Friedrich Reinhold. Kalevipoeg. Tallinn : Avita, 1997. Wello Uuskyla kiri Kreutzwaldi Memoriaalmuuseumile. Aimi Hollo kommentaar

  14. Eesti oma disainigalerii / Tiina Kolk

    Index Scriptorium Estoniae

    Kolk, Tiina

    2004-01-01

    Tallinnas Laial tänaval avatud galerii "Eesti ese" tutvustab eesti tootedisainerite loomingut. Galerist Ene Pars. Sisustuseks on kasutatud Ivari Männi "Flix-Flax" riiuleid ja laudu. Kauba tutvustus. 4 ill

  15. Suurte tüdrukute lelud / Inga Raitar

    Index Scriptorium Estoniae

    Raitar, Inga, 1966-

    1997-01-01

    Ärimeeste abikaasade isiklikud firmad: Anu Peets (salong "Donna"), Piret Kulo (Lloyd Eesti esindus), Ene Lepikson (ilusalong "Charme"), Dolores Kalvin (kauplus "Dolores"), Ülle Luik (hulgifirma "Tex Trade"), Ingrid Tõniste (firma "Bretting")

  16. Manifestically correct / Harry Liivrand

    Index Scriptorium Estoniae

    Liivrand, Harry, 1961-

    2000-01-01

    Euroopa kaasaegse kunsti biennaal Manifesta 3 Ljubljanas deviisi all "Piirijoone sündroom. Kaitsmise energiad". Eestit esindab Ene-Liis Semper videoinstallatsiooniga "FF / Rew". Aleksandr Breneri aktsioonist. Bosnia-Hersegoviina kunstniku Sejla Kamerici tööst jm

  17. Kuuskordkuus - Edenkobeni eksperiment / Doris Kareva

    Index Scriptorium Estoniae

    Kareva, Doris, 1958-

    1998-01-01

    23.-25. sept. toimus Reinimaal Edenkobenis kirjandussündmus 'Naabrite luule: kirjanikud tõlgivad kirjanikke', kus osalesid Jaan Kaplinski, Paul-Eerik Rummo, Ene Mihkelson, Viivi Luik, Doris Kareva ja Hasso Krull

  18. Sundhedsdebatten der blev væk, en føljeton i flere akter

    DEFF Research Database (Denmark)

    Smed, Sinne

    2013-01-01

    Den ene dag udtrykker politikerne begejstring for priserne som reguleringsinstrument, for den næste dag at mene at priserne ingen betydning har. Hvilken betydning har det for befolkningens tillid til politikerne og i sidste ende for folkesundheden?...

  19. Lwati: A Journal of Contemporary Research

    African Journals Online (AJOL)

    Maternal Love, Social and Political Activism as Vehicles of Self Assertion in the Poetry of Langston Hughes · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Ene Edem Ekpo, 73-89 ...

  20. Pariis kui uus peatus inimese teekonnal / Katre Talviste

    Index Scriptorium Estoniae

    Talviste, Katre

    2003-01-01

    Karl Ristikivi "Inimese teekonna" tõlkest prantsuse keelde ("Chemin terrestre", tõlkija Tarah Montbélialtz, pseud, kirj. La Guillotine, Pariis, 2002). Ka Claude Merlini ja Ene Rämmeldi lavastusest "Inimese teekond"

  1. New labdane diterpenes from Solidago canadensis.

    Science.gov (United States)

    Wangensteen, Helle; Phan, Thi T; Rise, Frode; Halvorsen, Trine G; Malterud, Karl E

    2012-01-01

    The ethanol extract of roots of Solidago canadensis yielded eight labdane-type diterpenes. Five of those were new natural compounds (9,13,15,16-bisepoxy-labdane-7-ene-6,15-dione (3a), 13-epi-9,13,15,16-bisepoxy-labdane-7-ene-6,15-dione (3b), 15,16-epoxy-labdane-7,13-diene-6,16-dione (5), 15-ethoxy-9,13,15,16-bisepoxy-labdane-7-ene-6-one (6a) and 13-epi-15-ethoxy-9,13,15,16-bisepoxy-labdane-7-ene-6-one (6b). The known labdane diterpenes deoxysolidagenone (1), solidagenone (2) and 15,16-epoxy-labdane-7,13-diene-6,15-dione (4) were also isolated. Chemical structures were determined using 1D and 2D NMR techniques and MS analysis.

  2. Алексий II 1929-2008

    Index Scriptorium Estoniae

    2008-01-01

    Aleksius II meenutavad: Kornelius, Tallinna ja kogu Eesti metropoliit ; Karin Jaani ; Marina Kaljurand ; Dmitri Medvedev, Venemaa president ; Helene Kamzol, Aleksius II sugulane ; Ain Seppik ; Vladimir Illjashevitsh ; Edgar Savisaar ; Jevgeni Tomberg ; Ene Ergma ; Toomas Hendrik Ilves, Eesti Vabariigi president

  3. Soomlane teeb Eestis iga kuu jõuluvana / Vilja Kohler

    Index Scriptorium Estoniae

    Kohler, Vilja, 1966-

    2008-01-01

    Soomlased Esa Tasanen ja Marja Korpimäki jagavad Alatskivil ja Pala vallas humanitaarabi. Küsimusele, kas Eesti inimesed vajavad veel humanitaarabi, vastavad Maret Maripuu, Ene Sõber, Vladimir Shokman, Aime Koger

  4. Raamatututvustus / Rein Põder

    Index Scriptorium Estoniae

    Põder, Rein, 1943-

    1995-01-01

    Tyler, Anne. Perekonnalõuna koduigatsuse restoranis; Sacher-Masoch, Leopold von. Venus karusnahas; Valik muinasjutte : Sinine vöö / Koost., tlk. ja lastele ümber jutustanud Ene ja Paul Ambur; Friday, Nancy. Armukadedus

  5. Kas hakkas hirm võõrale maale ära kaduda? / Mööna Tilder

    Index Scriptorium Estoniae

    Tilder, Mööna

    2010-01-01

    Eike Ülevainu, Jaak Sapase ning Eneli Meresmaa lavastus "Estonia Meets Africa ehk Vaade eemalt", mis kannab tinglikult dokumentaallavastuse nime ja esitatakse nüüdistantsu ja -teatri vormis. Esietendus 9. dets. Tallinna Meistrite Hoovi teatrisaalis

  6. Tantsuline vaade kodusele Eestimaale Aafrikast / Tiiu Laks

    Index Scriptorium Estoniae

    Laks, Tiiu, 1984-

    2009-01-01

    9. dets. esietendub Tallinna Meistrite Hoovi teatrisaalis Eike Ülevainu, Jaak Sapase ning Eneli Meresmaa lavastus "Estonia Meets Africa ehk Vaade eemalt", mis kannab tinglikult dokumentaallavastuse nime ja esitatakse nüüdistantsu ja -teatri vormis

  7. Neli + püha = kostüüm / Tambet Kaugema

    Index Scriptorium Estoniae

    Kaugema, Tambet

    1998-01-01

    Tallinnas Niguliste muuseum-kontserdisaalis kostüümidraama 'Neli + püha', mille korraldasid Jaanus Orgusaar, Ene Liis Semper, Aldo Järvsoo ja Tanel Veenre. Etendus toimus 'Barclay Atmosphere Art Is Everywhere' sarjas

  8. Semper lõi Manifestal laineid / Ants Juske

    Index Scriptorium Estoniae

    Juske, Ants, 1956-2016

    2000-01-01

    Manifesta 3, euroopa kaasaegse kunsti biennaal "Piirisündroom" Ljubljanas kuni 24. septembrini. Eestit esindas Ene-Liis Semperi video "FF/Rew". Järjekordse skandaali - piserdas pulverisaatorist presiidiumilauda ja videoekraani - korraldas venelane Aleksandr Brener

  9. Ilmus kogumik oreleist ja oreli kultuurist

    Index Scriptorium Estoniae

    2007-01-01

    XXI rahvusvahelise orelifestivali eel esitleti Niguliste kirikus Eesti Orelisõprade Ühingu väljaandel ilmunud kogumikku "XXI pilku orelile. Eesti orelikultuurist" (koostanud Ene Pilliroog ja Ivalo Randalu)

  10. Raamatututvustus: lugemine kui mäng / Külliki Kask

    Index Scriptorium Estoniae

    Kask, Külliki, 1949-

    2009-01-01

    Tutvustus: Eco, Umberto. Kuus jalutuskäiku kirjandusmetsades / inglise keelest tõlkinud Ene-Reet Soovik. Tallinn : Varrak, 2009 ; Martin, George R. R. Windhaven / tõlkinud Jaana Talja. [Tartu] : Fantaasia, c2009

  11. Vaata inimest. Näe elu / Margit Tõnson

    Index Scriptorium Estoniae

    Tõnson, Margit, 1978-

    2011-01-01

    Teater NO99 lavastusest "The Rise and Fall of Estonia" Nokia Kontserdimajas. Idee, kontseptsioon ja lavastus Tiit Ojasoo ja Ene-Liis Semper. Viktor Pelevini "Kollane nool" Ugala teatris, lavastaja Mart Koldits

  12. Peaminister Juhan Parts ei plaani ametit maha panna / Juhan Parts ; interv. Toomas Sildam

    Index Scriptorium Estoniae

    Parts, Juhan, 1966-

    2004-01-01

    Peaminister Juhan Parts pooldab paremerakondade ühinemist, ei kavatse ametist lahkuda ning peab valitsuse üheks ülesandeks rahvaarutelu algatamist vabaduse samba üle. Lisa: Ene Ergma kõnest Riigikogus (13.09.2004)

  13. Stolitsa baltiskoi modõ / Vladimir Stroi

    Index Scriptorium Estoniae

    Stroi, Vladimir

    2005-01-01

    Riias toimunud Balti moenädalast (Baltic Fashion Week) ja seal näidatud kollektsioonidest. Eestit esindasid Ene (?Evelin) Lill kollektsiooniga "Puudutus" ja Kätlin Kängsepp "Muudatuste uued tuuled"

  14. Regional tectonic trends on the inner continental shelf off Konkan and central west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Ramana, M.V.

    Satellite imagery and offshore magnetic data were analysed to correlate regional tectonic elements on the inner continental shelf off Konkan and the adjacent Deccan plateau. Three statistically important lineament trends N-S, WNW-ESE and ENE...

  15. Estraadi comeback. Ojasoo - Semperi "Nafta!" kui XXI sajandi estraadilavastus / Ott Karulin

    Index Scriptorium Estoniae

    Karulin, Ott, 1980-

    2006-01-01

    Estraadi sugemetega etendustest ja estraaditeatrist Eestis. Pikemalt peatutakse Ene-Liis Semperi ja Tiit Ojasoo lavastustel "Nafta", "No More Tears", "Julia" (aut. W. Shakespeare - T. Ojasoo) ja "Kuningas Ubu" (aut. A. Jarry)

  16. Halonen arrives for State visit / Ella Karapetyan

    Index Scriptorium Estoniae

    Karapetyan, Ella

    2010-01-01

    Eestis riigivisiidil viibinud Soome president Tarja Halonen kohtus peaminister Andrus Ansipi ja Riigikogu spiikri Ene Ergmaga. Presidendiga visiidil kaasas olnud Soome haridusminister Henna Virkkunen kohtus haridus- ja teadusminister Tõnis Lukasega

  17. GenBank blastx search result: AK110598 [KOME

    Lifescience Database Archive (English)

    Full Text Available ene/o-xylene monooxygenase (touABCDEF), putative gene encoding a transposase, ORF1 and ORF2 DNA and touR gene encoding sigma 54-dependent transcriptional activator.|BCT BCT 7e-80 +2 ...

  18. GenBank blastx search result: AK103964 [KOME

    Lifescience Database Archive (English)

    Full Text Available ene/o-xylene monooxygenase (touABCDEF), putative gene encoding a transposase, ORF1 and ORF2 DNA and touR gene encoding sigma 54-dependent transcriptional activator.|BCT BCT 9e-11 +3 ...

  19. GenBank blastx search result: AK058594 [KOME

    Lifescience Database Archive (English)

    Full Text Available ene/o-xylene monooxygenase (touABCDEF), putative gene encoding a transposase, ORF1 and ORF2 DNA and touR gene encoding sigma 54-dependent transcriptional activator.|BCT BCT 9e-11 +3 ...

  20. Adrenal Androgens and the Menopausal Transition

    OpenAIRE

    Lasley, B. L.; Crawford, S.; McConnell, D.S.

    2011-01-01

    The concept that adrenal androgen production gradually declines with age has changed following the analysis of the longitudinal data collected in the Study of Women’s Health Across the Nation (SWAN). It is now recognized that four adrenal androgens (3-beta hydroxy-5-androsten-17-one or dehydroepiandrosterone--DHEA, its sulfate, dehydroepiandrosterone sulfate--DHEAS; androst-4-ene, 3,17-dione or androstenedione; and androst-5-ene-3-beta, 17-beta diol, also known as androstenediol or Adiol) ris...

  1. Environmental Assessment for Installation of a New Jet Engine Test Cell, Edwards Air Force Base, California

    Science.gov (United States)

    2012-09-01

    Acetal· Ethyle- Formal- Naph- Ethyle- Formal- Tested Power Setting h’"~ lbslhr’ dehyde Acrolein Ben~ene ben~ene dehyde thalene Scyrene Tolueue Xylenes...TIM Fuel Flow Engine!i per setting, .. I, Acetal- Ethyle- Formal- Naph- Ethyle- Formal- Tested Power Settin hours lb lhrl. dehyde Acrolein Benzene...ENVIRONMENTAL ASSESSMENT FOR INSTALLATION OF A NEW JET ENGINE TEST CELL EDWARDS AIR FORCE BASE, CALIFORNIA September

  2. Regio-and Stereospecific Construction of Vicinal Quaternary Carbons: Total Synthesis of (±)-Albene

    OpenAIRE

    Srikrishna, Adusumilli; Nagaraju, Sankuratri

    1995-01-01

    A regiospecific and stereoselective total synthesis of the trisnorsesquiternene (±)-albene, via a prochiral precursor is described. The ortho ester Claisen rearrangement of the allyl alcohol, obtained in two regiospecific reactions from a Diels-Alder adduct, followed by hydrolysis of the resultant ester furnished an ene acid in a highly stereoselective manner. Anhydrous copper sulphate catalysed intramolecular cyclopropanation reaction of the diazo ketone derived from the ene acid, generated ...

  3. Marine natural products : integrated spectroscopic solutions for structure elucidation

    OpenAIRE

    Morinaka, Brandon Isamu

    2011-01-01

    This dissertation describes the structure determination and biological activity of four groups of sponge derived secondary metabolites by integrated approaches using synthesis and circular dichroism. Chapter 2 describes the isolation and structure determination of brominated ene- yne tetrahydrofuran fatty acids, mutafurans A-G from the marine sponge Xestospongia muta. Two optically active ene- yne tetrahydrofuran model compounds were synthesized for chiroptical comparison to the natural produ...

  4. Proof of the Structure of the Stemodia chilensis Tetracyclic Diterpenoid (+)-19-Acetoxystemodan-12-ol by Synthesis from (+)-Podocarpic Acid: X-ray Structure Determination of a Key Intermediate.

    Science.gov (United States)

    Leonelli, Francesca; Mostarda, Azzurra; De Angelis, Luca; Lamba, Doriano; Demitri, Nicola; La Bella, Angela; Ceccacci, Francesca; Migneco, Luisa M; Marini Bettolo, Rinaldo

    2016-04-22

    The first synthesis of (+)-19-acetoxystemodan-12-ol (1), a stemodane diterpenoid isolated from Stemodia chilensis, is described. The structure was supported by an X-ray crystallographic analysis of intermediate (+)-9a, which confirmed the proposed structure and excluded the structure of (-)-19-hydroxystemod-12-ene as a possible candidate for the Chilean Calceolaria diterpenoid to which the (-)-19-hydroxystemar-13-ene structure (9b) had been erroneously assigned.

  5. Conservation of a Triple-Helix-Forming RNA Stability Element in Noncoding and Genomic RNAs of Diverse Viruses

    Directory of Open Access Journals (Sweden)

    Kazimierz T. Tycowski

    2012-07-01

    Full Text Available Abundant expression of the long noncoding (lnc PAN (polyadenylated nuclear RNA by the human oncogenic gammaherpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV depends on a cis-element called the expression and nuclear retention element (ENE. The ENE upregulates PAN RNA by inhibiting its rapid nuclear decay through triple-helix formation with the poly(A tail. Using structure-based bioinformatics, we identified six ENE-like elements in evolutionarily diverse viral genomes. Five are in double-stranded DNA viruses, including mammalian herpesviruses, insect polydnaviruses, and a protist mimivirus. One is in an insect picorna-like positive-strand RNA virus, suggesting that the ENE can counteract cytoplasmic as well as nuclear RNA decay pathways. Functionality of four of the ENEs was demonstrated by increased accumulation of an intronless polyadenylated reporter transcript in human cells. Identification of these ENEs enabled the discovery of PAN RNA homologs in two additional gammaherpesviruses, RRV and EHV2. Our findings demonstrate that searching for structural elements can lead to rapid identification of lncRNAs.

  6. Soil thermal properties at two different sites on James Ross Island in the period 2012/13

    Science.gov (United States)

    Hrbáček, Filip; Láska, Kamil

    2015-04-01

    James Ross Island (JRI) is the largest island in the eastern part of the Antarctic Peninsula. Ulu Peninsula in the northern part of JRI is considered the largest ice free area in the Maritime Antarctica region. However, information about permafrost on JRI, active layer and its soil properties in general are poorly known. In this study, results of soil thermal measurements at two different sites on Ulu Peninsula are presented between 1 April 2012 and 30 April 2013. The study sites are located (1) on an old Holocene marine terrace (10 m a. s. l.) in the closest vicinity of Johann Gregor Mendel (JGM) Station and (2) on top of a volcanic plateau named Johnson Mesa (340 m a. s. l.) about 4 km south of the JGM Station. The soil temperatures were measured at 30 min interval using platinum resistance thermometers Pt100/8 in two profiles up to 200 cm at JGM Station and 75 cm at Johnson Mesa respectively. Decagon 10HS volumetric water content sensors were installed up 30 cm at Johnson Mesa to 50 cm at JGM Station, while Hukseflux HFP01 soil heat flux sensors were used for direct monitoring of soil physical properties at 2.5 cm depth at both sites. The mean soil temperature varied between -5.7°C at 50 cm and -6.3°C at 5 cm at JGM Station, while that for Johnson Mesa varied between -6.9°C at 50 cm and -7.1°C at 10 cm. Maximum active layer thickness estimated from 0 °C isotherm reached 52 cm at JGM Station and 50 cm at Johnson Mesa respectively which corresponded with maximum observed annual temperature at 50 cm at both sites. The warmest part of both profiles detected at 50 cm depth corresponded with maximum thickness of active layer, estimated from 0°C isotherm, reached 52 cm at JGM Station and 50 cm at Johnson Mesa respectively. Volumetric water content at 5 cm varied around 0.25 m3m-3 at both sites. The slight increase to 0.32 m3m-3 was observed at JGM Station at 50 cm and at Johnson Mesa at 30 cm depth. Soil texture analysis showed distinctly higher share of coarser

  7. Glacial–interglacial dynamics of Antarctic firn columns: comparison between simulations and ice core air-δ15N measurements

    Directory of Open Access Journals (Sweden)

    E. Capron

    2013-05-01

    Full Text Available Correct estimation of the firn lock-in depth is essential for correctly linking gas and ice chronologies in ice core studies. Here, two approaches to constrain the firn depth evolution in Antarctica are presented over the last deglaciation: outputs of a firn densification model, and measurements of δ15N of N2 in air trapped in ice core, assuming that δ15N is only affected by gravitational fractionation in the firn column. Since the firn densification process is largely governed by surface temperature and accumulation rate, we have investigated four ice cores drilled in coastal (Berkner Island, BI, and James Ross Island, JRI and semi-coastal (TALDICE and EPICA Dronning Maud Land, EDML Antarctic regions. Combined with available ice core air-δ15N measurements from the EPICA Dome C (EDC site, the studied regions encompass a large range of surface accumulation rates and temperature conditions. Our δ15N profiles reveal a heterogeneous response of the firn structure to glacial–interglacial climatic changes. While firn densification simulations correctly predict TALDICE δ15N variations, they systematically fail to capture the large millennial-scale δ15N variations measured at BI and the δ15N glacial levels measured at JRI and EDML – a mismatch previously reported for central East Antarctic ice cores. New constraints of the EDML gas–ice depth offset during the Laschamp event (~41 ka and the last deglaciation do not favour the hypothesis of a large convective zone within the firn as the explanation of the glacial firn model–δ15N data mismatch for this site. While we could not conduct an in-depth study of the influence of impurities in snow for firnification from the existing datasets, our detailed comparison between the δ15N profiles and firn model simulations under different temperature and accumulation rate scenarios suggests that the role of accumulation rate may have been underestimated in the current description of firnification

  8. Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer.

    Directory of Open Access Journals (Sweden)

    Sura Aziz

    Full Text Available Presence of lymph node (LN metastasis is a strong prognostic factor in breast cancer, whereas the importance of extra-nodal extension and other nodal tumor features have not yet been fully recognized. Here, we examined microscopic features of lymph node metastases and their prognostic value in a population-based cohort of node positive breast cancer (n = 218, as part of the prospective Norwegian Breast Cancer Screening Program NBCSP (1996-2009. Sections were reviewed for the largest metastatic tumor diameter (TD-MET, nodal afferent and efferent vascular invasion (AVI and EVI, extra-nodal extension (ENE, number of ENE foci, as well as circumferential (CD-ENE and perpendicular (PD-ENE diameter of extra-nodal growth. Number of positive lymph nodes, EVI, and PD-ENE were significantly increased with larger primary tumor (PT diameter. Univariate survival analysis showed that several features of nodal metastases were associated with disease-free (DFS or breast cancer specific survival (BCSS. Multivariate analysis demonstrated an independent prognostic value of PD-ENE (with 3 mm as cut-off value in predicting DFS and BCSS, along with number of positive nodes and histologic grade of the primary tumor (for DFS: P = 0.01, P = 0.02, P = 0.01, respectively; for BCSS: P = 0.02, P = 0.008, P = 0.02, respectively. To conclude, the extent of ENE by its perpendicular diameter was independently prognostic and should be considered in line with nodal tumor burden in treatment decisions of node positive breast cancer.

  9. Sesquiterpenes from the seeds of Guarea guidonia (Meliaceae); Sesquiterpenos de sementes de Guarea guidonia (Meliaceae)

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Luzinatia Ramos [Departamento de Quimica, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS (Brazil); Silva, Alene Cortes de Queiroz e; Freire, Talita Vilalva; Garcez, Fernanda Rodrigues; Garcez, Walmir Silva [Departamento de Quimica, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS (Brazil)

    2012-07-01

    Two new sesquiterpenes 6{alpha}-ethoxyeudesm-4(15)-en-1{beta}-ol (1) and (7R{sup *})-5-epi-opposit-4(15)-ene-1{beta},7-diol (7) were isolated from the seeds of a specimen of Guarea guidonia (Meliaceae). Five other known sesquiterpenes, eudesm-4(15)-ene-1{beta},6a-diol (2), 5-epi-eudesm-4(15)-ene-1{beta},6{beta}-diol (3), eudesm-4(15)-ene-1{beta},5a-diol (4), eudesm-4(15),7-dien-1{beta}-ol (5) and (7R{sup *})-opposit-4(15)-ene-1{beta},7-diol (6), were also isolated in this work. Their structures were determined on the basis of spectral data (MS, IR, and NMR-1D and 2D) and subsequent comparisons with the literature. The substances 3, 4 and 6 are reported for the first time in Meliaceae and 5 for the first time in the genus Guarea. (author)

  10. GC-MS study of Nigella sativa (seeds fatty oil

    Directory of Open Access Journals (Sweden)

    Mehta, B. K.

    2002-06-01

    Full Text Available The GC-MS study of N. sativa (seeds fatty oil revealed the presence of 26 compounds which were identified as methyl hept-6-enoate,1-phenylhepta-2,4-dione, pentadecane, hexadec-1-ene, 1-phenyldecan-2-one, octadec-1-ene, octadecane, methyl pentadecanoate, bis(3-chlorophenyl ketone, diethyl phthalate, ethyl octadec-7-enoate, methyl octadecanoate, tricos-9-ene, octadeca-9,12-dienoic acid, hexadecanoic acid, methyl hexadecanoate, methyl octadec-15-enoate, henicosan-10-one, 2-methyl octadecanoic acid, docos-1-ene, ethyl octadecanoate, methyl octadecanoate, pentacos-5-ene,12-methyltricosane, dibutyl phthalate and 2-methyltetracosane.El estudio por GC-MS del aceite de la semilla de Nigella sativa reveló la presencia de 26 compuestos los cuales fueron identificados como: hept-6-enoato de metilo, 1-fenilhepta-2,4-diona, pentadecano, hexadec-1-eno, 1-fenildecan-2-ona, octadec-1-eno, octadecano, pentadecanoato de metilo, bis(3-clorofenil cetona, ftalato de dietilo, octadec-7-enoato de etilo, octadecanoato de metilo, tricos-9-eno, ácido octadeca-9,12-dienoico, ácido hexadecanoico, hexadecanoato de metilo, octadec-15-enoato de metilo, henicosan-10-ona, ácido 2-metil octadecanoico, docos-1-eno, octadecanoato de etilo, octadecanoato de metilo, pentacos-5-eno, 12-metiltricosano, ftalato de dibutilo y 2-metiltetracosano.

  11. Sequence Controlled Polymers from a Novel β-Cyclodextrin Core.

    Science.gov (United States)

    Abdouni, Yamin; Yilmaz, Gökhan; Becer, C Remzi

    2017-12-01

    In this work the synthesis and use of a novel β-cyclodextrin-based single electron transfer-living radical polymerization (SET-LRP) initiator are reported. Three different approaches toward the synthesis of this initiator, based on several "click"-like reactions (copper(I)-catalyzed azide-alkyne cycloaddition, nucleophilic thiol-ene reaction, and radical thiol-ene reaction), are explored and discussed. Synthesis via radical thiol-ene proves to be most successful in achieving this. The β-cyclodextrin-based initiator is subsequently used for the polymerization of several acrylates in a controlled fashion, yielding 7-arm multiblock copolymers. The achieved sequence-controlled polymers exhibit low dispersities (≤1.12) and are completed under 6.5 h at high monomer conversion (≥95%) for each block. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Antibacterial diterpenes from Plectranthus ernstii.

    Science.gov (United States)

    Stavri, Michael; Paton, Alan; Skelton, Brian W; Gibbons, Simon

    2009-06-01

    Three new diterpenoids including two pimaranes (1 and 2) and a labdane (3) were isolated from the whole herb of Plectranthus ernstii. The structures of these compounds were determined as rel-15(zeta),16-epoxy-7alpha-hydroxypimar-8,14-ene (1) and rel-15(zeta),16-epoxy-7-oxopimar-8,14-ene (2), and compound 3 was elucidated as 1R,11S-dihydroxy-8R,13R-epoxylabd-14-ene on the basis of single-crystal X-ray structural analysis. Compound 1 exhibited moderate antistaphylococcal activity against a range of multidrug-resistant (MDR) and methicillin-resistant (MRSA) strains of Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 32 microg/mL. All three diterpenes exhibited antimycobacterial activity against three strains of rapidly growing mycobacteria with MIC values ranging from 8 to 128 microg/mL.

  13. Chemical constituents from Aspidosperma illustre (Apocynaceae)

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa, Lara F.; Mathias, Leda; Braz-Filho, Raimundo; Vieira, Ivo J. Curcino, E-mail: curcino@uenf.b [Universidade Estadual do Norte Fluminense Darcy Ribeiro (LCQ/UENF), Campos dos Goytacazes, RJ (Brazil). Lab. de Ciencias Quimicas

    2010-07-01

    A new natural product oleanane-type triterpene, olean-12-ene-11{alpha}-methoxy-3{beta}-acetate (10) was isolated from Aspidosperma illustre, together with {beta}-amyrin (3), lupeol (4), {beta}-amyrin acetate (5), lupeol acetate (6), olean-12-ene-28-hydroxy-3{alpha}-tetradecanoate (7), olean-12-ene-28-carboxy-3{alpha}-hexadecanoate (8), ursolic acid (9) triterpenes, and two monoterpenic indole alkaloids, b-yoimbine (1) and 1,2-dehydroaspidospermidine (2). These compounds were characterized on their spectral data basis, mainly one- ({sup 1}H, {sup 13}C, APT) and two-dimensional ({sup 1}H-{sup 1}H-COSY, {sup 1}H-{sup 1}HNOESY, HMQC and HMBC) NMR, and mass spectra, involving also comparison with data from the literature. (author)

  14. Synthesis, characterization and anticancer studies of new steroidal oxadiazole, pyrrole and pyrazole derivatives

    Directory of Open Access Journals (Sweden)

    Shamsuzzaman

    2015-07-01

    Full Text Available In the present study steroidal derivatives, 3β-[5′-mercapto-1′,3′,4′-oxadiazole-2-yl]methoxy cholest-5-ene 2, 3β-[2′,5′-dimethylpyrrole-1-yl]aminocarbonylmethoxycholest-5-ene 3 and 3β-[3′,5′-dimethyl pyrazole-1-yl]carbonylmethoxycholest-5-ene 4 have been synthesized from cholest-5-en-3β-O-acetyl hydrazide 1 using CS2/KOH, acetonyl acetone and acetyl acetone, respectively as reagents and are characterized by IR, 1H NMR,13C NMR, MS and elemental analysis. Compounds 2–4 were also evaluated for anticancer activity against human leukemia cell line (HL-60 by MTT assay and compound 4 displayed the promising behavior by showing better anticancer activity.

  15. Three new triterpene esters from pumpkin (Cucurbita maxima) seeds.

    Science.gov (United States)

    Kikuchi, Takashi; Ueda, Shinsuke; Kanazawa, Jokaku; Naoe, Hiroki; Yamada, Takeshi; Tanaka, Reiko

    2014-04-16

    Three new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2), and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3), were isolated from seeds of Cucurbita maxima, along with the known compound, multiflora-7,9(11)-diene-3α,29-diol 3,29-dibenzoate (4). Compound 1 exhibited melanogenesis inhibitory activities comparable with those of arbutin. In cytotoxicity assays, compounds 1 and 3 exhibited weak cytotoxicity, with IC50 values of 34.5-93.7 μM against HL-60 and P388 cells.

  16. Three New Triterpene Esters from Pumpkin (Cucurbita maxima Seeds

    Directory of Open Access Journals (Sweden)

    Takashi Kikuchi

    2014-04-01

    Full Text Available Three new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1, 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2, and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3, were isolated from seeds of Cucurbita maxima, along with the known compound, multiflora-7,9(11-diene-3α,29-diol 3,29-dibenzoate (4. Compound 1 exhibited melanogenesis inhibitory activities comparable with those of arbutin. In cytotoxicity assays, compounds 1 and 3 exhibited weak cytotoxicity, with IC50 values of 34.5–93.7 μM against HL-60 and P388 cells.

  17. Phytochemical study of the wood from Guarea macrophylla (Meliaceae); Estudo fitoquimico da madeira de Guarea macrophylla (Meliaceae)

    Energy Technology Data Exchange (ETDEWEB)

    Lago, Joao Henrique G. [Universidade Federal de Sao Paulo (UNIFESP), Diadema, SP (Brazil). Dept. de Ciencias Exatas e da Terra; Roque, Nadia F. [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil). Inst. de Quimica

    2009-07-01

    In the present work, the crude ethanol extract from wood of G. macrophylla was submitted to liquid/liquid partition between hexane, CH){sub 2}Cl{sub 2}, EtOAc and n-BuOH. Each phase was individually chromatographed over silica gel, Sephadex LH-20 or Amberlite XAD-2 to give eight terpene derivatives, such as five sesquiterpenoids (caryophyllene oxide, guai-6-en-10 beta-ol, spathulenol, aromadendrane-4 beta,10 alpha-diol and aloaromadendrane-4 alpha,10 beta-diol) as well as three triterpenoids (cicloart-24-ene-3 beta,23(R*)-diol, cicloart-24-ene-3 beta,23(S*)-diol, and cicloart-23E-ene-3 beta,25-diol). Additionally, were isolated three fatty acids (linolenic, linoleic and stearic), two steroids (sitosterol and stigmasterol) and sacarose. The structures of all these compounds were characterized by spectrometric analysis, mainly mass spectrometry and NMR and comparison of these data described in the literature. (author)

  18. Triterpenoids and flavonoids from celery (Apium graveolens).

    Science.gov (United States)

    Zhou, Kailan; Zhao, Feng; Liu, Zhihui; Zhuang, Yulei; Chen, Lixia; Qiu, Feng

    2009-09-01

    Three new triterpenoids, 11,21-dioxo-2beta,3beta,15alpha-trihydroxyurs-12-ene-2-O-beta-D-glucopyranoside (1), 11,21-dioxo-3beta,15alpha,24-trihydroxyurs-12-ene-24-O-beta-D-glucopyranoside (2), and 11,21-dioxo-3beta,15alpha,24-trihydroxyolean-12-ene-24-O-beta-D-glucopyranoside (3), and two new flavonoids, apigenin-7-O-[2''-O-(5'''-O-feruloyl)-beta-D-apiofuranosyl]-beta-D-glucopyranoside (4) and chrysoeriol-7-O-[2''-O-(5'''-O-feruloyl)-beta-D-apiofuranosyl]-beta-d-glucopyranoside (5), were isolated from the whole plant of fresh celery (Apium graveolens), together with 10 known flavonoids. The structures of the new compounds were elucidated by analysis of spectroscopic data. The inhibitory effects of the compounds isolated on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated.

  19. Mizoginija, mizandrija, satira : bilješke uz tri pjesme iz starije hrvatske književnosti

    OpenAIRE

    Plejić Poje, Lahorka

    2008-01-01

    U članku se proučavaju tri satirične pjesme: dvije koje iz pozicije muškoga kazivača napadaju žene i jedna u kojoj se ženskim glasom napadaju muškarci. Propituju se strategije napada u sve tri pjesme i njihova unutartekstna uvjerljivost. Pjesme se pokušavaju omjeriti o uvriježene definicije satire, pri čemu se pokazuje da su uvriježene definicije upitne i da ne odgovaraju na pitanja koja satirični tekstovi otvaraju. Naime, pjesme protiv žena niti žele niti mogu uputiti na poroke i grijehe žen...

  20. Estudo fitoquímico da madeira de Guarea macrophylla (Meliaceae Phytochemical study of the wood from Guarea macrophylla (Meliaceae

    Directory of Open Access Journals (Sweden)

    João Henrique G. Lago

    2009-01-01

    Full Text Available In the present work, the crude ethanol extract from wood of G. macrophylla was submitted to liquid/liquid partition between hexane, CH2Cl2, EtOAc and n-BuOH. Each phase was individually chromatographed over silica gel, Sephadex LH-20 or Amberlite XAD-2 to give eight terpene derivatives, such as five sesquiterpenoids (caryophyllene oxide, guai-6-en-10β-ol, spathulenol, aromadendrane-4β,10α-diol and aloaromadendrane-4α,10β-diol as well as three triterpenoids (cicloart-24-ene-3β,23(R*-diol, cicloart-24-ene-3β,23(S*-diol, and cicloart-23E-ene-3β,25-diol. Additionally, were isolated three fatty acids (linolenic, linoleic and stearic, two steroids (sitosterol and stigmasterol and sacarose. The structures of all these compounds were characterized by spectrometric analysis, mainly mass spectrometry and NMR and comparison of these data described in the literature.

  1. Senior High School English National Examination and Thinking Skills

    Directory of Open Access Journals (Sweden)

    Ummu Lathifah Ahmad

    2016-12-01

    Full Text Available When English National Examination (abbreviated into ENE as a norm-referenced test is designed for instructional purposes, to evaluate the result of national curriculum, it is very significant to conduct item test evaluation since it gives a clear portrait of the quality of the items and of the test as a whole. The purpose of this study was to analyze which levels of the Barrett taxonomy were more reflected in ENE items of 2013/2014 academic year and whether the proportions of items among the twenty test packages in the ENE assessing students’ Lower Order Thinking Skills (LOTS and Higher Order Thinking Skills (HOTS are consistent. The researcher adopted the qualitative descriptive approach using a content analysis card to codify the ENE items. To ensure the reliability of the study, three inter-raters analyzed a sample of the test packages. The results indicated that questions asking LOTS still prevailed in ENE items. Of all the twenty test packages, the items categorized into literal level represented around 68.6% of the total number of the questions. Meanwhile, the questions belonging to reorganization came to occupy a percentage of 20.8 and the questions asking the students’ inferential level only reached 10.3%. Also, the tests were not enriched sufficiently with the evaluation comprehension since they only comprised 0.3%. The results also showed the complete absence of “Appreciation” – the highest level of thinking in the mentioned taxonomy. It is obvious that there is a shortage of items questioning students’ HOTS in the exam and they are not well-treated. Accordingly, this finding reveals that there is still much room for ENE to be the driving force in the effort to make learners critical thinkers. In the light of these data, this study recommends modifying the English National Exam by providing them with more question items that include HOTS.

  2. In vitro evaluation of the cytotoxic and trypanocidal activities of Ampelozizyphus amazonicus (Rhamnaceae

    Directory of Open Access Journals (Sweden)

    L.V. Rosas

    2007-05-01

    Full Text Available Ampelozizyphus amazonicus Ducke is a tree commonly found in the Amazon region and an extract of its stem bark is popularly used as an antimalarial and anti-inflammatory agent and as an antidote to snake venom. Ursolic acid; five lupane type triterpenes: betulin, betulinic acid, lupenone, 3ß-hydroxylup-20(29-ene-27,28-dioic acid, and 2a,3ß-dihydroxylup-20(29-ene-27,28-dioic acid, and three phytosteroids: stigmasterol, sitosterol and campesterol, have been isolated from stem extracts of A. amazonicus Ducke. Their structures were characterized by spectral data including COSY and HMQC. In an in vitro biological screening of the isolated compounds, 3ß-hydroxylup-20(29-ene-27,28-dioic acid was cytotoxic against the SKBR-3 human adenocarcinoma cell line (1 to 10 mg/mL, while 2a,3ß-dihydroxylup-20(29-ene-27,28-dioic acid exhibited cytotoxicity against both SKBR-3 human adenocarcinoma and C-8161 human melanoma tumor cell lines (>0.1 mg/mL. In the present study, different extracts and some fractions of this plant were also investigated for trypanocidal activity due to the presence of pentacyclic triterpenes. The triterpene classes are potent against Trypanosoma cruzi. The bioassays were carried out using blood collected from Swiss albino mice by cardiac puncture during the parasitemic peak (7th day after infection with the Y strain of T. cruzi. The results obtained showed that A. amazonicus is a potential source of bioactive compounds since its extracts and fractions isolated from it exhibited in vitro parasite lysis against trypomastigote forms of T. cruzi at concentrations >100 µg/mL. Fractions containing mainly betulin, lupenone, 3ß-hydroxylup-20(29-ene-27,28-dioic acid, and 2a,3ß-dihydroxylup-20(29-ene-27,28-dioic acid showed more activity than crude extracts.

  3. Two new cucurbitane triterpenoids from the seeds of Momordica charantia.

    Science.gov (United States)

    Ma, Lin; Yu, Ai-Hua; Sun, Li-Li; Gao, Wan; Zhang, Meng-Meng; Su, Ya-Lun; Liu, Hua; Ji, Teng-Fei; Li, Di-Zao

    2014-01-01

    Two new cucurbitane triterpenoids 1 and 2 were isolated, together with six known compounds, from the seeds of Momordica charantia L. The structures of new compounds were determined to be 3-O-{[β-d-galactopyranosyl(1 → 6)]-O-β-d-galactopyranosyl}-23(R), 24(R), 25-trihydroxycucur-bit-5-ene (1), 3-O-[β-d-galactopyranosyl]-25-O-β-d-galactopyranosyl-7(R), 22(S), 23(R), 24(R), 25-pentahydroxycucurbit-5-ene (2), respectively. Their structures were elucidated by the combination of mass spectrometry, one- and two-dimensional NMR experiments and chemical reactions.

  4. Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima Seeds

    Directory of Open Access Journals (Sweden)

    Reiko Tanaka

    2013-05-01

    Full Text Available Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1, 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2, and multiflora-7,9(11-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3, were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11-diene-3a-29-diol 3-benzoate (5 exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells.

  5. Three new multiflorane-type triterpenes from pumpkin (Cucurbita maxima) seeds.

    Science.gov (United States)

    Kikuchi, Takashi; Takebayashi, Mika; Shinto, Mayumi; Yamada, Takeshi; Tanaka, Reiko

    2013-05-14

    Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)-diene-3a-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells.

  6. IZDELAVA PROTOTIPA OHIŠJA UPARJALNIKA S POSTOPKOM LITJA Z IZGUBLJENIM JEDROM

    OpenAIRE

    Križnik, Mitja

    2012-01-01

    Pri izdelavi aluminijastih prototipov v tej diplomski nalogi bomo za izdelavo uporabili postopek litja z izgubljenim jedrom. Pri tem postopku se najprej izdela prototip s 3D printerjem. Nato na podlagi prototipa izdelamo silikonsko orodje, s pomočjo katerega bomo izdelovali voščene pramodele. Voščene pramodele bomo pritrdili na voščeno drevo, ga zalili z mavcem, izžgali vosek ter nato ulili aluminijevo zlitino v nastali kalup. S tem dobimo aluminijaste prototipe ohišja uparjalnika, ki so cilj...

  7. Gender stereotypes analysis in cartoons broadcasted on Croatian televisions

    OpenAIRE

    Rudančić, Vlatka

    2015-01-01

    Rodni stereotipi postoje od kada postoje muškarci i žene, njihovo značenje roda i spola. Od samih početaka razvoja pismenosti (od doba Aristotela) muškarci su bili oni koji su išli u lov i čije se mišljenje uvažavalo, dok su žene ostajale doma, rađale djecu i brinule se o njima. Istraživanje se temelji na osamdeset analiziranih crtanih filmova koji se prikazuju na hrvatskim nacionalnim TV postajama te prikazuju postojanje rodnih stereotipa u svim pregledanim materijalima. Metoda koja se koris...

  8. Ester-free cross-linker molecules for ultraviolet-light-cured polysilsesquioxane gate dielectric layers of organic thin-film transistors

    Science.gov (United States)

    Okada, Shuichi; Nakahara, Yoshio; Uno, Kazuyuki; Tanaka, Ichiro

    2018-04-01

    Pentacene thin-film transistors (TFTs) were fabricated with ultraviolet-light (UV)-cured polysilsesquioxane (PSQ) gate dielectric layers using cross-linker molecules with or without ester groups. To polymerize PSQ without ester groups, thiol-ene reaction was adopted. The TFTs fabricated with PSQ layers comprising ester-free cross-linkers showed a higher carrier mobility than the TFTs with PSQ layers cross-linked with ester groups, which had large electric dipole moments that limited the carrier mobility. It was demonstrated that the thiol-ene reaction is more suitable than the conventional radical reaction for UV-cured PSQ with small dielectric constant.

  9. Chemotaxonomic study of the demosponge Cinachyrella cavernosa (Lamarck)

    Digital Repository Service at National Institute of Oceanography (India)

    Wahidullah, S.; Naik, B.G.; Al-Fadhli, A.A.

    .J., 1991. Steroids of the marine sponge Cinachyra tarentina: isolation of cholest-4-ene-3, 6-dione and (24R)-24 ethyl cholest-4ene-3, 6-dione. J. Nat. Prod. 54, 281-285. Al-Bari, A., Alam-Bhuiyan, M.S., Flores, M.E, Petrosyan, P., Varela, M.G., Anwarul-Islam..., Academic Press, New York, pp 75-172, 241-297. Hochmuth, D.H., Joulain, D., Konig, W.A., 2004. Mass Finder software and data Bank, University of Hamburg. Available from wwwmassfinder.com Itoh, T., Tani, H., Fukushima, K., Tamura, T., Matsumoto, T., 1982...

  10. Woody Alleni komöödia Rakveres / Peeter Raudsepp

    Index Scriptorium Estoniae

    Raudsepp, Peeter, 1974-

    1999-01-01

    Rakvere Teatris esietendub 15. okt "Suveöö seksikomöödia", Woody Alleni filmistsenaariumi on näidendiks kirjutanud Jürgen Fischer, lavastab külalisena Rednar Annus, kunstnikud on Ene -Liis Semper ja Raoul Kurvitz, muusikaline kujundaja Tamur Tohver.

  11. Ingmar Muusikuse foto Flash Artis

    Index Scriptorium Estoniae

    1999-01-01

    Flash Arti 1999. a. oktoobrinumbris virtuaalse näituse rubriigis Ando Keskküla artikkel radikaalsemast eesti kunstist ja kunstielust postsotsialistlikul ajastul. Illustratsiooniks Liina Siibi fotokompositsioonid, Ingmar Muusikuse foto Raoul Kurvitza, Ene-Liis Semperi ja Kiwa Eesti Panga performance'ist

  12. Hy kom met die skoenlappers. 'n Elegie aan verlore liefde. Valda ...

    African Journals Online (AJOL)

    We hebben hem of haar allemaal—die ene liefde van lang (of niet zo lang) geleden. Die liefde die voor altijd perfect zal blijven want het is eigenlijk altijd net imaginair gebleven. Het is de liefde waaraan we altijd denken als er iets mis gaat in onze reële verhouding, het is de liefde waarmee we elke andere verhoud-.

  13. Hvad skal vi med en hjerne?

    DEFF Research Database (Denmark)

    Hermansen, Judy

    2009-01-01

      Debatten om Martin Lindstrøms Buyology har vist, at ikke alle sluger neuromarketing hypen råt. Brødrene Perrachione - den ene hjerneforsker og den anden marketingforsker - giver her deres bud på, hvor neurovidenskab og marketing har noget at sige hinanden. Hjernens fornemste opgave er, ifølge...

  14. Health benefits of soy beans and soy products: a review | Venter ...

    African Journals Online (AJOL)

    Heel sojabone bevat 40% proteïene, terwyl sojameel, sojaproteïenkonsentraat en geïsoleerde sojaproteïen respektiewelik 50%, 70% en 90% proteïen bevat. Verskeie nie-nutriëntbestanddele soos isoflavone, protease-inhibeerders, fitiensuur, saponiene en fitosterole kom in sojabone voor en is moontlik vir sekere van die ...

  15. Semperi videod Utrechtis

    Index Scriptorium Estoniae

    2001-01-01

    Ene-Liis Semperi personaalnäitus "Oasis" Utrechtis kaasaegse kunsti keskuses BeganeGrond. Näitusekomplekti moodustavad viis videotööd aastast 1998-2000. Näituse korraldaja on keskuse direktor Maria Hlavajová. Näitust reklaamitakse Hollandi kunstiajakirjas "Metropolis M"

  16. Audible thunder characteristic and the relation between peak ...

    Indian Academy of Sciences (India)

    ity of natural lightning, resulting in inadequate data on lightning spectra at present. Thunder sig- ... A single pulse will evolve to the shape of an N wave; further propagation of the wave produces a length- ening of ..... and effects (New York: Cambridge University Press), pp. 321–346. Uman M A 2001 The lightning discharge ...

  17. Leinapäeva õppetund

    Index Scriptorium Estoniae

    2007-01-01

    Vabariigi Presidendi Toomas Hendrik Ilvese, Riigikogu esimehe Ene Ergma ja peaminister Andrus Ansipi ühisavaldus 14. juunil 2007. Ingl. k. ilmunud ka: Vaba Eesti Sõna 21. juuni 2007, lk. 12, pealk.: Day of Mourning: Joint statement of the President of the Republic, the President of the Riigikogu and the Prime Minister

  18. Videokunsti parimad stiilinäited Kumus

    Index Scriptorium Estoniae

    2010-01-01

    Kumu Kunstimuuseumis avatakse 28. oktoobril 2010 rahvusvaheline videokunsti näitus "Kõik saab korda". Osalevad Marina Abramović (Serbia/USA), Eija-Liisa Ahtila (Soome), Kai Kaljo, Mike Marshall (Inglismaa), Ene-Liis Semper, Santeri Tuori (Soome), Guido van der Werve (Holland)

  19. Annual Meeting of the Academy of Sciences USSR. 24-26 February 1960

    Science.gov (United States)

    1960-08-29

    automationA ,,f the coal enrichment. % nev process of ozidation pyrolysis of natural and industrial gases to obtain unlimited hydrocarbons (etkl~ene...wherever there is energy it is possible to obtain agricultural products. In particular, for example, it became evident that in cultivating tomatoes , 2...Organophosphorous Compounds.................. ..... 170, 2499 25C Oxidation Pyrolysis . . ..... e c eee e. ................ 132 Paramagnetic Amplifiers

  20. Innovation

    DEFF Research Database (Denmark)

    Torfing, Jacob; Ricard, Lykke Margot

    2017-01-01

    Innovation i krydsfeltet mellem forskellige styringsparadigmer i offentlige organisationer. New Public Governance gør det muligt at skabe offentlig værdi på nye måder. Men NPG er ingen trylledrik, der fra den ene dag til den anden skaber balance mellem borgernes store forventninger og en trængt...