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Sample records for endpoint energy bremsstrahlung

  1. The isomeric ratios in photonuclear reactions of natural barium induced by bremsstrahlungs with endpoint energies in the giant dipole resonance region

    International Nuclear Information System (INIS)

    Tran Duc Thiep; Truong Thi An; Phan Viet Cuong; Nguyen The Vinh

    2012-01-01

    We have determined the isomeric ratios in 130 Ba(γ, n) 129m,g Ba, 132 Ba(γ, n) 131m,g Ba and 134 Ba(γ, n) 133m,g Ba photonuclear reactions of natural barium induced by bremsstrahlungs with end-point energies in the giant dipole resonance region. The investigated samples were irradiated at electron accelerator Microtron MT-25 of the Flerov Laboratory of Nuclear Reaction, Joint Institute for Nuclear Research, Dubna, Russia. The gamma spectra of the samples irradiated were measured with spectroscopic system consisting of 8192 channel analyzer and high-energy resolution (180 keV at gamma ray 1332 keV of 60 Co) HP(Ge) semiconductor detector Canberra. The GENIE2000 (Canberra) computer program was used for data processing. The results were discussed and compared with those of other authors. (author)

  2. Photo-neutron reaction cross-section for 93Nb in the end-point bremsstrahlung energies of 12–16 and 45–70 MeV

    International Nuclear Information System (INIS)

    Naik, H.; Kim, G.N.; Schwengner, R.; Kim, K.; Zaman, M.; Tatari, M.; Sahid, M.; Yang, S.C.; John, R.; Massarczyk, R.; Junghans, A.; Shin, S.G.; Key, Y.; Wagner, A.; Lee, M.W.; Goswami, A.; Cho, M.-H.

    2013-01-01

    The photo-neutron cross-sections of 93 Nb at the end-point bremsstrahlung energies of 12, 14 and 16 MeV as well as 45, 50, 55, 60 and 70 MeV have been determined by the activation and the off-line γ-ray spectrometric techniques using the 20 MeV electron linac (ELBE) at Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany, and 100 MeV electron linac at Pohang Accelerator Laboratory (PAL), Pohang, Korea. The 93 Nb(γ, xn, x=1–4) reaction cross-sections as a function of photon energy were also calculated using computer code TALYS 1.4. The flux-weighted average values were obtained from the experimental and the theoretical (TALYS) values based on mono-energetic photons. The experimental values of present work are in good agreement with the flux-weighted theoretical values of TALYS 1.4 but are slightly higher than the flux-weighted experimental data of mono-energetic photons. It was also found that the theoretical and the experimental values of present work and literature data for the 93 Nb(γ, xn) reaction cross-sections increase from the threshold values to a certain energy, where other reaction channels opens. However, the increase of 93 Nb(γ, n) and 93 Nb(γ, 2n) reaction cross-sections are sharper compared to 93 Nb(γ, 3n) and 93 Nb(γ, 4n) reaction cross-sections. The sharp increase of 93 Nb(γ, n) and 93 Nb(γ, 2n) reaction cross-sections from the threshold value up to 17–22 MeV is due to the Giant Dipole Resonance (GDR) effect besides the role of excitation energy. After a certain values, the individual 93 Nb(γ, xn) reaction cross-sections decrease with increase of bremsstrahlung energy due to opening of other reaction channels

  3. Measurement of activation yields for platinum group elements using Bremsstrahlung radiation with end-point energies in the range 11-14 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Tickner, James, E-mail: james.tickner@csiro.a [CSIRO Process Science and Engineering, PMB 5, Menai, NSW 2234 (Australia); Bencardino, Raffaele; Roach, Greg [CSIRO Process Science and Engineering, PMB 5, Menai, NSW 2234 (Australia)

    2010-01-15

    Activation yields have been measured for (gamma,n) reactions of the elements Ru, Rh, Pd, Ir and Pt. Metallic foils of natural isotopic composition were irradiated using Bremsstrahlung radiation produced from an electron linear accelerator operated with electron beam energies in the range 11-14 MeV. Activation products, including both unstable ground states and metastates were measured using a high-purity germanium detector. Cross-sections were estimated from the yield data by assuming a simple two-parameter model for the shape of the cross-section with energy.

  4. Measurement of activation yields for platinum group elements using Bremsstrahlung radiation with end-point energies in the range 11-14 MeV

    International Nuclear Information System (INIS)

    Tickner, James; Bencardino, Raffaele; Roach, Greg

    2010-01-01

    Activation yields have been measured for (γ,n) reactions of the elements Ru, Rh, Pd, Ir and Pt. Metallic foils of natural isotopic composition were irradiated using Bremsstrahlung radiation produced from an electron linear accelerator operated with electron beam energies in the range 11-14 MeV. Activation products, including both unstable ground states and metastates were measured using a high-purity germanium detector. Cross-sections were estimated from the yield data by assuming a simple two-parameter model for the shape of the cross-section with energy.

  5. Measurement of photo-neutron cross sections and isomeric yield ratios in the {sup 89}Y(γ,xn){sup 89-x}Y reactions at the bremsstrahlung end-point energies of 65, 70 and 75 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Tatari, Mansoureh [Yazd Univ. (Iran, Islamic Republic of). Physics Dept.; Naik, Haladhara [Bhabha Atomic Research Centre, Mumbai (India). Radiochemistry Div.; Kim, Guinyun; Kim, Kwangsoo [Kyungpook National Univ., Daegu (Korea, Republic of). Dept. of Physics; Shin, Sung-Gyun; Cho, Moo-Hyun [Pohang Univ. of Science and Technology (Korea, Republic of). Div. of Advanced Nuclear Engineering

    2017-07-01

    The flux-weighted average cross sections of the {sup 89}Y(γ,xn; x=1-4){sup 89-x}Y reactions and the isomeric yield ratios of the {sup 87m,g}Y, {sup 86m,g}Y, and {sup 85m,g}Y radionuclides produced in these reactions with the bremsstrahlung end-point energies of 65, 70 and 75 MeV have been determined by an activation and off-line γ-ray spectrometric technique using the 100 MeV electron linac in Pohang Accelerator Laboratory, Korea. The theoretical {sup 89}Y(γ,xn; x=1-4){sup 89-x}Y reaction cross sections for mono-energetic photons have been calculated using the computer code TALYS 1.6. Then the flux-weighted theoretical values were obtained to compare with the present data. The flux-weighted experimental and theoretical {sup 89}Y(γ,xn; x=1-4){sup 89-x}Y reaction cross sections increase very fast from the threshold values to a certain bremsstrahlung energy, where the other reaction channels open up. Thereafter it remains constant a while and then slowly decreases with the increase of cross sections for other reactions. Similarly, the isomeric yield ratios of {sup 87m,g}Y, {sup 86m,g}Y and {sup 85m,g}Y in the {sup 89}Y(γ,xn; x=2-4){sup 89-x}Y reactions from the present work and literature data show an increasing trend from their respective threshold values to a certain bremsstrahlung energy. After a certain point of energy, the isomeric yield ratios increase slowly with the bremsstrahlung energy. These observations indicate the role of excitation energy and its partitioning in different reaction channels.

  6. Measurement of flux-weighted average cross-sections and isomeric yield ratios for {sup 103}Rh(γ, xn) reactions in the bremsstrahlung end-point energies of 55 and 60 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Shakilur Rahman, Md.; Kim, Kwangsoo; Kim, Guinyun; Nadeem, Muhammad; Thi Hien, Nguyen; Shahid, Muhammad [Kyungpook National University, Department of Physics, Daegu (Korea, Republic of); Naik, Haladhara [Bhabha Atomic Research Centre, Radiochemistry Division, Mumbai (India); Yang, Sung-Chul; Cho, Young-Sik; Lee, Young-Ouk [Korea Atomic Energy Research Institute, Nuclear Data Center, Daejeon (Korea, Republic of); Shin, Sung-Gyun; Cho, Moo-Hyun [Pohang University of Science and Technology, Division of Advanced Nuclear Engineering, Pohang (Korea, Republic of); Woo Lee, Man; Kang, Yeong-Rok; Yang, Gwang-Mo [Dongnam Institute of Radiological and Medical Science, Research Center, Busan (Korea, Republic of); Ro, Tae-Ik [Dong-A University, Department of Materials Physics, Busan (Korea, Republic of)

    2016-07-15

    We measured the flux-weighted average cross-sections and the isomeric yield ratios of {sup 99m,g,100m,g,101m,g,102m,g}Rh in the {sup 103}Rh(γ, xn) reactions with the bremsstrahlung end-point energies of 55 and 60 MeV by the activation and the off-line γ-ray spectrometric technique, using the 100 MeV electron linac at the Pohang Accelerator Laboratory (PAL), Korea. The flux-weighted average cross-sections were calculated by using the computer code TALYS 1.6 based on mono-energetic photons, and compared with the present experimental data. The flux-weighted average cross-sections of {sup 103}Rh(γ, xn) reactions in intermediate bremsstrahlung energies are the first time measurement and are found to increase from their threshold value to a particular value, where the other reaction channels open up. Thereafter, it decreases with bremsstrahlung energy due to its partition in different reaction channels. The isomeric yield ratios (IR) of {sup 99m,g,100m,g,101m,g,102m,g}Rh in the {sup 103}Rh(γ, xn) reactions from the present work were compared with the literature data in the {sup 103}Rh(d, x), {sup 102-99}Ru(p, x), {sup 103}Rh(α, αn), {sup 103}Rh(α, 2p3n), {sup 102}Ru({sup 3}He, x), and {sup 103}Rh(γ, xn) reactions. It was found that the IR values of {sup 102,101,100,99}Rh in all these reactions increase with the projectile energy, which indicates the role of excitation energy. At the same excitation energy, the IR values of {sup 102,101,100,99}Rh are higher in the charged particle-induced reactions than in the photon-induced reaction, which indicates the role of input angular momentum. (orig.)

  7. Beta Emission and Bremsstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Karpius, Peter Joseph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-11-13

    Bremsstrahlung is continuous radiation produced by beta particles decelerating in matter; different beta emitters have different endpoint energies; high-energy betas interacting with high-Z materials will more likely produce bremsstrahlung; depending on the data, sometimes all you can say is that a beta emitter is present.

  8. High energy bremsstrahlung in an intense laser field

    International Nuclear Information System (INIS)

    Schlessinger, L.; Wright, J.A.

    1980-02-01

    The cross section for bremsstrahlung emission and absorption by electrons in an intense laser field has been calculated in the Born approximation for the electron-ion potential. Typical numerical results are presented as a function of the ratio of the electron guiver energy to its energy and the ratio of the bremsstrahlung energy to the electron energy. The intense field correction factor for the rate of bremsstrahlung emission and absorption for electrons with a Boltzmann distribution of energies has been calculated. Numerical results for the correction factor are presented for the Boltzmann case as a function of the ratio of the electron quiver energy to its thermal energy and the ratio of the bremsstrahlung energy to the thermal energy. For typical laser fusion parameters, this correction factor which is the ratio of the thermal bremsstrahlung emission rate in the intense laser field to the rate at zero field can be quite significant. For a laser of wavelength 1.06 μm at an intensity of 3 x 10 15 w/cm 2 and an electron temperature of 1 keV, the correction factor varies from 0.98 at a bremsstrahlung energy of 100 V to greater than 5 at a bremsstrahlung energy of 10 keV

  9. Differential bremsstrahlung and pair production cross sections at high energies

    International Nuclear Information System (INIS)

    Olsen, Haakon A.

    2003-01-01

    Detailed differential cross sections for high energy bremsstrahlung and pair production are derived with specific attention to the differences between the two processes, which are considerable. For the integrated cross sections, which are the only cross sections specifically known until now, the final state integration theorem guarantees that the exact cross section formulas can be exchanged between bremsstrahlung and pair production by the same substitution rules as for the Born-approximation Bethe-Heitler cross sections, for any amount of atomic screening. In fact the theorem states that the Coulomb corrections to the integrated bremsstrahlung and pair production cross sections are identical for any amount of screening. The analysis of the basic differential cross sections leads to fundamental physical differences between bremsstrahlung and pair production. Coulomb corrections occur for pair production in the strong electric field of the atom for 'large' momentum transfer of the order of mc. For bremsstrahlung, on the other hand, the Coulomb corrections take place at a 'large' distance from the atom of the order of ((ℎ/2π)/mc)ε, with a 'small' momentum transfer mc/ε, where ε is the initial electron energy in units of mc 2 . And the Coulomb corrections can be large, of the order of larger than (Z/137) 2 , which is considerably larger than the integrated cross section corrections

  10. A detector for use in high energy bremsstrahlung shielding studies

    International Nuclear Information System (INIS)

    Wilson, O.J.; Thomson, J.E.M.

    1983-01-01

    The design, development and calibration of a detector based on the principle of the Moxon-Rae detector is discussed. It is ideally suited to the measurement of the energy fluence of photons transmitted through a thick shield which has been irradiated with high energy bremsstrahlung. The detection sensitivity is 10 4 to 10 5 times that of the P2 ion chamber

  11. Partial decay energy of 51Cr from inner bremsstrahlung spectrum

    International Nuclear Information System (INIS)

    Sanjeeviah, H.; Sanjeevaiah, B.

    1980-01-01

    The inner bremsstrahlung spectrum accompanying orbital electron capture decay of 51 Cr to the first excited state in 51 V was measured in coincidence with 320 keV gamma rays. From the Jauch plot of the spectrum the partial decay energy was deduced to be 433 +- 18 keV in good agreement with the previously measured value and the accepted mass difference. The overall shape factor of the inner bremsstrahlung spectrum was found to be a constant X(1.1 +- 0.1). (author)

  12. Possibility of some radionuclides production using high energy electron Bremsstrahlung

    International Nuclear Information System (INIS)

    Balzhinnyam, N.; Belov, A.G.; Gehrbish, Sh; Maslov, O.D.; Shvetsov, V.N.; Ganbold, G.

    2008-01-01

    The method of some radionuclides production using high energy Bremsstrahlung of electron accelerators and determination of photonuclear reaction yield and specific activities for some radionuclides is described. Photonuclear reaction yield and specific activities for some radionuclides are determined for 117m Sn, 111 In and 195m Pt. Based on the experimental data obtained at low energy (E e- e- = 75 MeV) of the IREN facility (FLNR, JINR) at irradiation of high purity platinum and tin metals

  13. Bremsstrahlung of La and its dependence on electron energy

    International Nuclear Information System (INIS)

    Riehle, F.

    1977-01-01

    Measurements of La-bremsstrahlung isocromates with high resolution for quantum energies between 135 eV and 1867 eV are presented and discussed. In the whole energy range investigated, the isocromate structure, identified with the 4f band of La, is placed 5,45 +- 10,1 eV above the Fermi level. This is in contradiction with a calculation of Gloetzel, which predicts the 4f band maximum about 3eV above the Fermi level. This discrepancy is explained in the present work by the fact that the La electronic density of states depends on the occupation number of the states. The bremsstrahlung isocromate has to be considered as a direct copy of the La ion density of states, consisting of the La-atom and the additional primary electron. Resonance like intensity modulations of the x-ray radiation, resulting from transitions of the primary electron in f-like final states, are observed in an analysis of the La-bremsstrahlung isochromate energy dependence. For transitions of the primary electron in d-like final states, no resonances have been found. The energy dependence of the scattering probability in f-like final states can be explained by a model which assumes the final state as composed by a continuum state and a discrete state. (orig.) [de

  14. Decay energy of 55Fe from its inner Bremsstrahlung spectrum

    Science.gov (United States)

    Keshava, S. L.; Gopala, K.; Venkataramaiah, P.

    2001-06-01

    Several measurements of decay energy using the inner Bremsstrahlung spectrum (IB) due to radiative electron capture in 55Fe has been made. But the results are not uniform. Hence another attempt has been made at the same. Experimental data was obtained with a 4.445 cm. dia ' 5.08 cm thick NaI (Tl) detector. It was subjected to suitable statistical treatment and various corrections using Liden and Starfelt procedure. The corrected spectrum agrees well with the Glauber and Martin theory for 1s electron capture beyond 100 keV. From the Jauch plot, the decay energy of 232.36 +/-0.64 keV was obtained.

  15. Bremsstrahlung and pair production in crystals at very high energies

    International Nuclear Information System (INIS)

    Nikishov, A.I.

    1981-01-01

    The probabilities for bremsstrahlung and pair production in crystals are discussed under stringent condition when the trajectory of the high-energy electron crosses very many atoms of a crystal row (or plane). It is shown that for sufficiently long path in such conditions the probabilities are described by the formulas for these processes in a strong constant magnetic field exerting on electron the same deflection as the atom row. It turns out that for lead at energy approximately 10 12 eV the radiation length is shortened many hundred times. For greater energies the decrease of probabilities per unit length with increase of energy goes as W varies as Esup(-1/3)

  16. Decay energy of 55Fe from its inner Bremsstrahlung spectrum

    International Nuclear Information System (INIS)

    Keshava, S.L.; Gopala, K.; Venkataramaiah, P.

    2001-01-01

    Several measurements of decay energy using the inner Bremsstrahlung spectrum (IB) due to radiative electron capture in 55 Fe has been made. But the results are not uniform. Hence another attempt has been made at the same. Experimental data was obtained with a 4.445 cm dia x 5.08 cm thick NaI (Tl) detector. It was subjected to suitable statistical treatment and various corrections using Liden and Starfelt procedure. The corrected spectrum agrees well with the Glauber and Martin theory for l s electron capture beyond 100 keV. From the Jauch plot, the decay energy of 232.36±0.64 keV was obtained. (author)

  17. Collimator and energy window optimization for 90Y bremsstrahlung SPECT imaging: A SIMIND Monte Carlo study

    International Nuclear Information System (INIS)

    Roshan, Hoda Rezaei; Mahmoudian, Babak; Gharepapagh, Esmaeil; Azarm, Ahmadreza; Pirayesh Islamian, Jalil

    2016-01-01

    Treatment efficacy of radioembolization using Yttrium-90 ( 90 Y) microspheres is assessed by the 90 Y bremsstrahlung single photon emission computed tomography (SPECT) imaging following radioembolization. The radioisotopic image has the potential of providing reliable activity map of 90 Y microspheres distribution. One of the main reasons of the poor image quality in 90 Y bremsstrahlung SPECT imaging is the continuous and broad energy spectrum of the related bremsstrahlung photons. Furthermore, collimator geometry plays an impressive role in the spatial resolution, sensitivity and image contrast. Due to the relatively poor quality of the 90 Y bremsstrahlung SPECT images, we intend to optimize the medium-energy (ME) parallel-hole collimator and energy window. The Siemens e.cam gamma camera equipped with a ME collimator and a voxelized phantom was simulated by the SImulating Medical Imaging Nuclear Detectors (SIMIND) program. We used the SIMIND Monte Carlo program to generate the 90 Y bremsstrahlung SPECT projection of the digital Jaszczak phantom. The phantom consist of the six hot spheres ranging from 9.5 to 31.8 mm in diameter, which are used to evaluate the image contrast. In order to assess the effect of the energy window on the image contrast, three energy windows ranging from 60 to 160 KeV, 160 to 400 KeV, and 60 to 400 KeV were set on a 90 Y bremsstrahlung spectrum. As well, the effect of the hole diameter of a ME collimator on the image contrast and bremsstrahlung spectrum were investigated. For the fixed collimator and septa thickness values (3.28 cm and 1.14 mm, respectively), a hole diameter range (2.35–3.3 mm) was chosen based on the appropriate balance between the spatial resolution and sensitivity. The optimal energy window for 90 Y bremsstrahlung SPECT imaging was extended energy window from 60 to 400 KeV. Besides, The optimal value of the hole diameter of ME collimator was obtained 3.3 mm. Geometry of the ME parallel-hole collimator and energy

  18. The role of phantom and treatment head generated bremsstrahlung in high-energy electron beam dosimetry

    International Nuclear Information System (INIS)

    Sorcini, B.B.; Hyoedynmaa, S.; Brahme, A.

    1996-01-01

    An analytical expression has been derived for the phantom generated bremsstrahlung photons in plane-parallel monoenergetic electron beams normally incident on material of any atomic number (Be, H 2 O, Al, Cu and U). The expression is suitable for the energy range from 1 to 50 MeV and it is solely based on known scattering power and radiative and collision stopping power data for the material at the incident electron energy. The depth dose distribution due to the bremsstrahlung generated by the electrons in the phantom is derived by convolving the bremsstrahlung energy fluence produced in the phantom with a simple analytical energy deposition kernel. The kernel accounts for both electrons and photons set in motion by the bremsstrahlung photons. The energy loss by the primary electrons, the build-up of the electron fluence and the generation, attenuation and absorption of bremsstrahlung photons are all taken into account in the analytical formula. The longitudinal energy deposition kernel is derived analytically and it is consistent with both the classical biexponential relation describing the photon depth dose distribution and the exponential attenuation of the primary photons. For comparison Monte Carlo calculated energy deposition distributions using ITS3 code were used. Good agreement was found between the results with the analytical expression and the Monte Carlo calculation. For tissue equivalent materials, the maximum total energy deposition differs by less than 0.2% from Monte Carlo calculated dose distributions. The result can be used to estimate the depth dependence of phantom generated bremsstrahlung in different materials in therapeutic electron beams and the bremsstrahlung production in different electron absorbers such as scattering foils, transmission monitors and photon and electron collimators. By subtracting the phantom generated bremsstrahlung from the total bremsstrahlung background the photon contamination generated in the treatment head can be

  19. Analytical expression for the phantom generated bremsstrahlung background in high energy electron beams

    International Nuclear Information System (INIS)

    Sorcini, B.B.; Hyoedynmaa, S; Brahme, A.

    1995-01-01

    Qualification of the bremsstrahlung photon background generated by an electron beam in a phantom is important for accurate high energy electron beam dosimetry in radiation therapy. An analytical expression has been derived for the background of phantom generated bremsstrahlung photons in plane parallel electron beams normally incident on phantoms of any atomic number between 4 and 92 (Be, C, H 2 O, Al, Cu, Ag, Pb and U). The expression can be used with fairly good accuracy in the energy range between 1 and 50 MeV. The expression is globally based on known scattering power and radiation and collision stopping power data for the phantom material at the mean energy of the incident electrons. The depth dose distribution due to the bremsstrahlung generated in the phantom is derived by folding the bremsstrahlung energy fluence with a simple analytical one-dimensional photon energy deposition kernel. The energy loss of the primary electrons and the generation, attenuation and absorption of bremsstrahlung photons are taken into account in the analytical formula. The photon energy deposition kernel is used to account for the bremsstrahlung produced at one depth that will contribute to the down stream dose. A simple analytical expression for photon energy deposition kernel is consistent with the classical analytical relation describing the photon depth dose distribution. From the surface to the practical range the photon dose increases almost linearly due to accumulation and buildup of the photon produced at different phantom layers. At depths beyond the practical range a simple exponential function can be use to describe the bremsstrahlung attenuation in the phantom. For comparison Monte Carlo calculated distributions using ITS3 Monte Carlo Code were used. Good agreement is found between the analytical expression and Monte Carlo calculation. Deviations of 5% from Monte Carlo calculated bremmstrahlung background are observed for high atomic number materials. The method can

  20. Soft electromagnetic bremsstrahlung in inelastic hadronic collisions at high and intermediate energies

    International Nuclear Information System (INIS)

    Rueckl, R.

    1978-01-01

    Electromagnetic bremsstrahlung in hadronic collisions was studied extensively at low and intermediate energies. It was found that the infrared divergent term of the cross section describes the data well up to surprisingly large photon energies. Using essentially the same soft photon approximation, production of low mass-low energy electron pairs via internal conversion of soft virtual bremsstrahlung accompanying the production of charged hadrons in hadron-hadron collisions at very high and intermediate energies. The resulting electron yields explain, at least in part, the direct electrons with small transverse momenta seen at the ISR, and are in no contradiction to the rates observed at LAMPF

  1. Electron-positron pair production and bremsstrahlung at intermediate energies in the field of heavy atoms

    International Nuclear Information System (INIS)

    Lee, R.N.; Milstein, A.I.; Strakhovenko, V.M.; Schwartz, O.Ya.

    2006-01-01

    The Coulomb corrections (CC) to the processes of bremsstrahlung and pair production are investigated. The next-to-leading term in the high-energy asymptotics is found. This term becomes very essential in the region of intermediate energies. The influence of screening for CC is small for differential cross section, spectrum, and the total cross section of pair production. The same is true for the spectrum of bremsstrahlung, but not for the differential cross section, where the influence of screening can be very large. The corresponding screening corrections as well as the modification of the differential cross section of bremsstrahlung are found. A comparison of our results for the total cross section of pair production with the experimental data available is performed. This comparison has justified our analytical results and allowed to elaborate a simple ansatz for the next-to-leading correction. The influence of the electron beam shape on CC for bremsstrahlung is investigated. It turns out that the differential cross section is very sensitive to this shape

  2. Endpoint behavior of high-energy scattering cross sections

    International Nuclear Information System (INIS)

    Chay, Junegone; Kim, Chul

    2010-01-01

    In high-energy processes near the endpoint, there emerge new contributions associated with spectator interactions. Away from the endpoint region, these new contributions are suppressed compared to the leading contribution, but the leading contribution becomes suppressed as we approach the endpoint and the new contributions become comparable. We present how the new contributions scale as we reach the endpoint and show that they are comparable to the suppressed leading contributions in deep inelastic scattering by employing a power-counting analysis. The hadronic tensor in deep inelastic scattering is shown to factorize including the spectator interactions, and it can be expressed in terms of the light cone distribution amplitudes of initial hadrons. We also consider the contribution of the spectator contributions in Drell-Yan processes. Here the spectator interactions are suppressed compared to double parton annihilation according to the power counting.

  3. Parametric Study of Beta-Endpoint Energy in Direct Energy Converters

    Science.gov (United States)

    2007-01-01

    value to the endpoint energy of nickel-63 ( Ni63 ), whose endpoint energy is 66 keV. Only an approximation is sought. Nickel-63 is an easily...is known to vary from Sr90’s spectrum, where instead of peaking at approximately one third of the endpoint energy, the peak of Ni63 ’s output spectrum

  4. An apparatus to study the energy and angular distributions of electron-bremsstrahlung photons from gaseous targets

    International Nuclear Information System (INIS)

    Yadav, Namita; Bhatt, Pragya; Singh, Raj; Singh, B.K.; Quarles, C.A.; Shanker, R.

    2014-01-01

    An apparatus is developed to measure the energy- and angular distributions of bremsstrahlung generated from collisions of energetic electrons with isolated atoms and molecules. A considerable reduction of thick target bremsstrahlung (TTB) background produced by scattered electrons from the chamber wall is achieved. Details of the experimental setup with regard to design of its components, experimental technique, data acquisition and analysis etc. are given and discussed. The reliability and performance of the setup are demonstrated by obtaining some test results on angular- and energy distributions of bremsstrahlung produced in collisions of 4.0 keV electrons with free argon atoms. These results are compared with the theoretical predictions of the ordinary- and the polarization bremsstrahlung emissions. In this comparison, the experimental data for energy distributions of BS photons are found to be in reasonable agreement while they are found to have noticeable differences in shape of angular distributions. - Highlights: • Experimental setup is developed to study DDCS of electron-bremsstrahlung from gaseous targets. • TTB from scattering chamber's wall is reduced appreciably by using a teflon cylinder. • Shape of DDCS of bremsstrahlung compared with the theories shows a satisfactory match. • Angular distributions of bremsstrahlung show anisotropy but still affected by TTB background photons

  5. Polarimetry of coherent bremsstrahlung by analysis of the photon energy spectrum

    International Nuclear Information System (INIS)

    Darbinyan, S.; Hakobyan, H.; Jones, R.; Sirunyan, A.; Vartapetian, H.

    2005-01-01

    A method of coherent bremsstrahlung (CB) polarimetry based on the analysis of the shape of the photon energy spectrum is presented. The influence of a number of uncertainty sources, including the choice of atomic form-factors, has been analyzed. For a CB source consisting of a diamond radiator and multi-GeV electrons, an absolute accuracy of polarimetry at the level of 0.01-0.02 is attainable

  6. Experimental and analytical study of the bremsstrahlung radiation production at low energies

    International Nuclear Information System (INIS)

    Moran, P.; Gonzales, L.; Delgado, V.; Lopez, A.; Vano, E.

    1986-01-01

    The bremsstrahlung photon beam from an X-ray tube with chromium anode has been studied, for an electron energy of 60 Kev. In the experimental step, a new measurement method has been developed. This is based on the detection and measurement of the fluorescence produced when the photons from the tube impinge on targets which are used as calibrated flux monitors. The composition and physical characteristics of the targets are well-known. In the steps of experimental data treatment, an analytical study of the theoretical models describing thick target bremsstrahlung yield is performed. A factorization which accounts for the elemental physical processes is obtained, employing simple mathematical functions. The characteristic parameters found in the numerical fit process lead to results in good agreement with the experimental observations from other authors and predict theoretical exposure values in perfect agreement with the exposures measured for X-ray beams generated in several operating conditions. (author)

  7. Monitoring system of energy characteristics of electron beam during shaping process of power bremsstrahlung pulses

    International Nuclear Information System (INIS)

    Mordasov, N.G.; Ulimov, V.N.; Bryksin, V.A.; Shiyan, V.D.

    2005-01-01

    One proposes a procedure and a device to monitor dynamic and integral characteristics of electron power beams of high-current pulsed accelerators (HCPA) operating under Bremsstrahlung radiation mode. One obtained static and dynamic transfer characteristics for various types of heterogenous targets-converters under operation of UIN-10 HCPA with up to 4 MeV energy electrons, up to 60 kA current and 6 x 10 -8 -2 x 10 -6 s pulse efficient duration. One demonstrated the capabilities of the complex diagnostics of acceleration of electron beams by HCPA with simultaneous determination of parameters of the Bremsstrahlung radiation at the local point of the field behind the target-converter [ru

  8. Hard X-ray bremsstrahlung production in solar flares by high-energy proton beams

    Science.gov (United States)

    Emslie, A. G.; Brown, J. C.

    1985-01-01

    The possibility that solar hard X-ray bremsstrahlung is produced by acceleration of stationary electrons by fast-moving protons, rather than vice versa, as commonly assumed, was investigated. It was found that a beam of protons which involves 1836 times fewer particles, each having an energy 1836 times greater than that of the electrons in the equivalent electron beam model, has exactly the same bremsstrahlung yield for a given target, i.e., the mechanism has an energetic efficiency equal to that of conventional bremsstrahlung models. Allowance for the different degrees of target ionization appropriate to the two models (for conventional flare geometries) makes the proton beam model more efficient than the electron beam model, by a factor of order three. The model places less stringent constraints than a conventional electron beam model on the flare energy release mechanism. It is also consistent with observed X-ray burst spectra, intensities, and directivities. The altitude distribution of hard X-rays predicted by the model agrees with observations only if nonvertical injection of the protons is assumed. The model is inconsistent with gamma-ray data in terms of conventional modeling.

  9. Low energy atomic field bremsstrahlung from thin rare gas targets

    International Nuclear Information System (INIS)

    Semaan, M.E.

    1982-01-01

    A relative measurement of the doubly-differential cross-section for electron atomic field bremsstrahling, differential in photon energy and angle is reported. Data for (d 2 sigma)/(dk dO/sub k/) have been taken for incident electron energies T ranging from 4 to 10 keV on target atoms of helium, neon, argon, krypton and xenon at a photon emission angle of 90 0 . The X-rays, produced at 90 0 to the intersection of the crossed electron and gas beams, are detected by a Si(Li) detector, having a resolution of about 200 eV at 6 keV and 0.3 mil Be window. The theoretical angular distribution (d 2 sigma)/(dk dO/sub k/) has been deduced from the photon energy spectrum by the use of the shape function S(Z,T,k,T) defined by Tseng and Pratt as S(Z,T,k,T) = [(d 2 sigma)/(dk dO/sub k/)] / [(dsigma)/(dk)]. The values of S used were obtained by an interpolation of the benchmark data provided by Pratt et al. Agreement between our experiment and the theory is measured by how well the theoretical curve fits the data. The agreement appeared to be good

  10. Thermal Bremsstrahlung probing nuclear multifragmentation in nucleus-nucleus collisions around the Fermi energy

    International Nuclear Information System (INIS)

    D'Enterria, D.G.

    2000-05-01

    The thermodynamical properties of nuclear matter at moderate temperatures and densities, in the vicinity of the predicted nuclear liquid-gas phase transition, are studied using as experimental probe the hard-photons (E γ > 30 MeV) emitted in nucleus-nucleus collisions. Photon and charged-particle production in four different heavy-ion reactions (Ar 36 + Au 197 , Ag 107 , Ni 58 , C 12 at 60 A*MeV) is measured exclusively and inclusively coupling the TAPS photon spectrometer with two charged-particle and intermediate-mass-fragment detectors covering nearly 4π. We confirm that Bremsstrahlung emission in first-chance (off-equilibrium) proton-neutron collisions (pnγ) is the dominant origin of hard photons. We also firmly establish the existence of a thermal radiation component emitted in second-chance proton-neutron collisions. This thermal Bremsstrahlung emission takes place in semi-central and central nucleus-nucleus reactions involving heavy targets. We exploit this observation i) to demonstrate that thermal equilibrium is reached during the reaction, ii) to establish a new thermometer of nuclear matter based on Bremsstrahlung photons, iii) to derive the thermodynamical properties of the excited nuclear sources and, in particular, to establish a 'caloric curve' (temperature versus excitation energy), and iv) to assess the time-scales of the nuclear break-up process. (author)

  11. Measurement of the internal bremsstrahlung spectrum of a 89Sr beta emitter in the 1–100 keV photon energy regime

    International Nuclear Information System (INIS)

    Singh, Amrit; Dhaliwal, A.S.

    2015-01-01

    The internal bremsstrahlung (IB) spectrum of 89 Sr, which is a unique first forbidden beta emitter, is studied in the 1–100 keV photon energy regime. The IB spectrum is experimentally measured using a Si(Li) detector, which is efficient in this photon energy regime, and is compared with the IB distributions that are predicted by the Knipp, Uhlenbeck and Bloch (KUB), Nilsson, and Lewis and Ford theories. In the soft energy regime up to 15 keV, the measured results are in agreement with all the aforementioned theories. However, from 16–30 keV, the experimental results are in agreement with the Lewis and Ford theory, which applies to forbidden transitions, and at higher photon energies, the Nilsson theory best describes the measured results. The differences among the different theories also increase with the photon energy. The effect of the electrostatic Coulomb field on the IB process for beta emitters with different end-point energies is investigated by comparing the ratio of the IB probabilities predicted using the KUB and Nilsson theories for 35 S and 89 Sr, i.e., soft and hard beta emitters, respectively. The Coulomb effect is shown to be significant in the high photon energy regime and for beta emitters with low end-point energies. - Highlights: • Internal bremsstrahlung spectrum of 89 Sr, a unique first forbidden beta emitter, is studied. • The measurements are taken in the photon energy regions of 1–100 keV with Si(Li) detector. • The measured results are deviating from Lewis and Ford theory and are close to the Nilsson theory. • The effect of Coulomb field on the IB process for different end point energy sources is investigated. • Effect of Coulomb field is more for low energy beta emitter towards the high energy end

  12. Secondary bremsstrahlung and the energy-conservation aspects of kerma in photon-irradiated media.

    Science.gov (United States)

    Kumar, Sudhir; Nahum, Alan E

    2016-02-07

    Kerma, collision kerma and absorbed dose in media irradiated by megavoltage photons are analysed with respect to energy conservation. The user-code DOSRZnrc was employed to compute absorbed dose D, kerma K and a special form of kerma, K ncpt, obtained by setting the charged-particle transport energy cut-off very high, thereby preventing the generation of 'secondary bremsstrahlung' along the charged-particle paths. The user-code FLURZnrc was employed to compute photon fluence, differential in energy, from which collision kerma, K col and K were derived. The ratios K/D, K ncpt/D and K col/D have thereby been determined over a very large volumes of water, aluminium and copper irradiated by broad, parallel beams of 0.1 to 25 MeV monoenergetic photons, and 6, 10 and 15 MV 'clinical' radiotherapy qualities. Concerning depth-dependence, the 'area under the kerma, K, curve' exceeded that under the dose curve, demonstrating that kerma does not conserve energy when computed over a large volume. This is due to the 'double counting' of the energy of the secondary bremsstrahlung photons, this energy being (implicitly) included in the kerma 'liberated' in the irradiated medium, at the same time as this secondary bremsstrahlung is included in the photon fluence which gives rise to kerma elsewhere in the medium. For 25 MeV photons this 'violation' amounts to 8.6%, 14.2% and 25.5% in large volumes of water, aluminium and copper respectively but only 0.6% for a 'clinical' 6 MV beam in water. By contrast, K col/D and K ncpt/D, also computed over very large phantoms of the same three media, for the same beam qualities, are equal to unity within (very low) statistical uncertainties, demonstrating that collision kerma and the special type of kerma, K ncpt, do conserve energy over a large volume. A comparison of photon fluence spectra for the 25 MeV beam at a depth of  ≈51 g cm−2 for both very high and very low charged-particle transport cut-offs reveals the considerable

  13. On the efficiency calibration of Si(Li) detector in the low-energy region using thick-target bremsstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    An, Z. E-mail: anzhu@scu.edu.cn; Liu, M.T

    2002-10-01

    In this paper, the efficiency calibration of a Si(Li) detector in the low-energy region down to 0.58 keV has been performed using thick-carbon-target bremsstrahlung by 19 keV electron impact. The shape of the efficiency calibration curve was determined from the thick-carbon-target bremsstrahlung spectrum, and the absolute value for the efficiency calibration was obtained from the use of {sup 241}Am radioactive standard source. The modified Wentzel's formula for thick-target bremsstrahlung was employed and it was also compared with the most recently developed theoretical model based upon the doubly differential cross-sections for bremsstrahlung of Kissel, Quarles and Pratt. In the present calculation of theoretical bremsstrahlung, the self-absorption correction and the convolution of detector's response function with the bremsstrahlung spectrum have simultaneously been taken into account. The accuracy for the efficiency calibration in the low-energy region with the method described here was estimated to be about 6%. Moreover, the self-absorption correction calculation based upon the prescription of Wolters et al. has also been presented as an analytical factor with the accuracy of {approx}1%.

  14. Calculation of Bremsstrahlung radiation of electrons on atoms in wide energy range of photons

    CERN Document Server

    Romanikhin, V P

    2002-01-01

    The complete spectra of the Bremsstrahlung radiation on the krypton atoms within the range of the photon energies of 10-25000 eV and lanthanum near the potential of the 4d-shell ionization is carried out. The atoms summarized polarizability is calculated on the basis of the simple semiclassical approximation of the local electron density and experimental data on the photoabsorption. The comparison with the calculational results is carried out through the method of distorted partial waves (PDWA) for Kr and with the experimental data on La

  15. Bremsstrahlung spectra from thick-target electron beams with noncollisional energy losses

    International Nuclear Information System (INIS)

    Brown, J.C.; MacKinnon, A.L.

    1985-01-01

    We consider what can be learned from the bremsstrahlung radiation of fast electrons in a thick target, generalized to include electron energy losses additional to collisions. We show that the observed photon spectrum can, in principle, be inverted to yield an integral functional of the electron spectrum and the effective energy loss rate. In the light of this result, there seems no reason to suppose, in the absence of a priori information to the contrary, that the photon spectrum is symptomatic more of the fast electron distribution than of the energy loss processes. In cases where the electron injection spectrum is known on independent observational or theoretical grounds, it is possible to infer an effective, ''phenomenological'' energy loss function. In the more general case, however, fullest possible modeling of the physical situation and comparison of the resulting spectrum with observations is all that can be attempted

  16. Initial studies of Bremsstrahlung energy deposition in small-bore superconducting undulator structures in linac environments

    Energy Technology Data Exchange (ETDEWEB)

    Cremer, T.; Tatchyn, R. [Stanford Univ., CA (United States)

    1995-12-31

    One of the more promising technologies for developing minimal-length insertion devices for linac-driven, single-pass Free Electron Lasers (FELs) operating in the x-ray range is based on the use of superconducting (SC) materials. In recent FEL simulations, for example, a bifilar helical SC device with a 2 cm period and 1.8 T field was found to require a 30 m saturation length for operation at 1.5{Angstrom} on a 15 GeV linac, more than 40% shorter than an alternative hybrid/permanent magnet (hybrid/PM) undulator. AT the same time, however, SC technology is known to present characteristic difficulties for insertion device design, both in engineering detail and in operation. Perhaps the most critical problem, as observed, e.g., by Madey and co-workers in their initial FEL experiments, was the frequent quenching induced by scattered electrons upstream of their (bifilar) device. Postulating that this quenching was precipitated by directly-scattered or bremsstrahlung-induced particle energy deposited into the SC material or into material contiguous with it, the importance of numerical and experimental characterizations of this phenomenon for linac-based, user-facility SC undulator design becomes evident. In this paper we discuss selected prior experimental results and report on initial EGS4 code studies of scattered and bremsstrahlung induced particle energy deposition into SC structures with geometries comparable to a small-bore bifilar helical undulator.

  17. Neutron-proton bremsstrahlung experiments

    Energy Technology Data Exchange (ETDEWEB)

    Koster, J.E. (Los Alamos National Lab., NM (United States)); Nelson, R.O. (Los Alamos National Lab., NM (United States)); Schillaci, M.E. (Los Alamos National Lab., NM (United States)); Wender, S.A. (Los Alamos National Lab., NM (United States)); Mayo, D. (Univ. of California at Davis, CA (United States)); Brady, F.P. (Univ. of California at Davis, CA (United States)); Romero, J. (Univ. of California at Davis, CA (United States)); Krofcheck, D. (Lawrence Livermore National Lab., CA (United States)); Blann, M. (Lawrence Livermore National Lab., CA (United States)); Anthony, P. (Lawrence Livermore National Lab., CA (United States)); Brown, V.R. (Lawrence Livermore National Lab., CA (United States)); Hansen, L. (Lawrence Livermore National Lab., CA (United States)); Pohl, B. (Lawrence Livermore National Lab., CA (United States)); Sangster, T.C. (Lawrence Livermore National Lab., CA (United States)); Nifenecker, H. (Inst. des Sciences Nucleaires, Grenoble (France)); Pinston,

    1993-06-01

    It is well known that charged particles emit bremsstrahlung radiation when they are accelerated. Classical electron bremsstrahlung occurs when a proton is emitted by an electron accelerated in the field of a nucleus. The bremsstrahlung process also occurs in the scattering of nucleons, for which it is the lowest energy inelastic process that can occur. Like electron bremsstrahlung, nucleon-nucleon bremsstrahlung also requires the exchange of a virtual particle to conserve energy and momentum. In electron bremsstrahlung a virtual photon is exchanged but with two nucleons a meson can be exchanged. Unlike electron bremsstrahlung, in nucleon-nucleon bremsstrahlung the photon can originate from the exchanged meson. This exchange contribution has been shown in calculations to be a significant fraction of bremsstrahlung events. Thus bremsstrahlung serves as a probe of exchange currents in the nucleon-nucleon interaction. Because of a lack of a free neutron target or an intense neutron beam, few measurements of neutron-proton bremsstrahlung exist, each having poor statistical accuracy and poor energy resolution. The white neutron source at the Weapons Neutron Research (WNR) target area at the Los Alamos Meson Physics Facility (LAMPF) produces neutrons with energies from below 50 to above 400 MeV. Using time-of-flight techniques and a liquid hydrogen target, we are measuring the outgoing photons of energies up to 250 MeV at gamma ray angles of around 90 relative to the incident beam. Protons scattered at very forward angles are also detected in coincidence with the gamma rays. (orig.)

  18. Polarization Bremsstrahlung

    CERN Document Server

    Korol, Andrey V

    2014-01-01

    This book introduces and reviews both theory and applications of polarizational bremsstrahlung, i.e. the electromagnetic radiation emitted during collisions of charged particles with structured, thus polarizable targets, such as atoms, molecules and clusters.   The subject, following the first experimental evidence a few decades ago, has gained importance through a number of modern applications.  Thus, the study of several radiative mechanisms is expected to lead to the design of novel light sources, operating in various parts of the electromagnetic spectrum. Conversely, the analysis of the spectral and angular distribution of the photon emission constitutes a new tool for extracting information on the interaction of the colliding particles, and on their internal structure and dynamical properties.   Last but not least, accurate quantitative descriptions of the photon emission processes determine the radiative energy losses of particles in various media, thereby providing essential  information required f...

  19. Benchmarking of Monte Carlo simulation of bremsstrahlung from thick targets at radiotherapy energies

    International Nuclear Information System (INIS)

    Faddegon, Bruce A.; Asai, Makoto; Perl, Joseph; Ross, Carl; Sempau, Josep; Tinslay, Jane; Salvat, Francesc

    2008-01-01

    Several Monte Carlo systems were benchmarked against published measurements of bremsstrahlung yield from thick targets for 10-30 MV beams. The quantity measured was photon fluence at 1 m per unit energy per incident electron (spectra), and total photon fluence, integrated over energy, per incident electron (photon yield). Results were reported at 10-30 MV on the beam axis for Al and Pb targets and at 15 MV at angles out to 90 degree sign for Be, Al, and Pb targets. Beam energy was revised with improved accuracy of 0.5% using an improved energy calibration of the accelerator. Recently released versions of the Monte Carlo systems EGSNRC, GEANT4, and PENELOPE were benchmarked against the published measurements using the revised beam energies. Monte Carlo simulation was capable of calculation of photon yield in the experimental geometry to 5% out to 30 degree sign , 10% at wider angles, and photon spectra to 10% at intermediate photon energies, 15% at lower energies. Accuracy of measured photon yield from 0 to 30 degree sign was 5%, 1 s.d., increasing to 7% for the larger angles. EGSNRC and PENELOPE results were within 2 s.d. of the measured photon yield at all beam energies and angles, GEANT4 within 3 s.d. Photon yield at nonzero angles for angles covering conventional field sizes used in radiotherapy (out to 10 degree sign ), measured with an accuracy of 3%, was calculated within 1 s.d. of measurement for EGSNRC, 2 s.d. for PENELOPE and GEANT4. Calculated spectra closely matched measurement at photon energies over 5 MeV. Photon spectra near 5 MeV were underestimated by as much as 10% by all three codes. The photon spectra below 2-3 MeV for the Be and Al targets and small angles were overestimated by up to 15% when using EGSNRC and PENELOPE, 20% with GEANT4. EGSNRC results with the NIST option for the bremsstrahlung cross section were preferred over the alternative cross section available in EGSNRC and over EGS4. GEANT4 results calculated with the ''low energy

  20. Benchmarking of Monte Carlo simulation of bremsstrahlung from thick targets at radiotherapy energies

    Energy Technology Data Exchange (ETDEWEB)

    Faddegon, Bruce A.; Asai, Makoto; Perl, Joseph; Ross, Carl; Sempau, Josep; Tinslay, Jane; Salvat, Francesc [Department of Radiation Oncology, University of California at San Francisco, San Francisco, California 94143 (United States); Stanford Linear Accelerator Center, 2575 Sand Hill Road, Menlo Park, California 94025 (United States); National Research Council Canada, Institute for National Measurement Standards, 1200 Montreal Road, Building M-36, Ottawa, Ontario K1A 0R6 (Canada); Institut de Tecniques Energetiques, Universitat Politecnica de Catalunya and Centro de Investigacion Biomedica en Red en Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Diagonal 647, 08028 Barcelona (Spain); Stanford Linear Accelerator Center, 2575 Sand Hill Road, Menlo Park, California 94025 (United States); Facultat de Fisica (ECM), Universitat de Barcelona, Societat Catalana de Fisica (IEC), Diagonal 647, 08028 Barcelona (Spain)

    2008-10-15

    Several Monte Carlo systems were benchmarked against published measurements of bremsstrahlung yield from thick targets for 10-30 MV beams. The quantity measured was photon fluence at 1 m per unit energy per incident electron (spectra), and total photon fluence, integrated over energy, per incident electron (photon yield). Results were reported at 10-30 MV on the beam axis for Al and Pb targets and at 15 MV at angles out to 90 degree sign for Be, Al, and Pb targets. Beam energy was revised with improved accuracy of 0.5% using an improved energy calibration of the accelerator. Recently released versions of the Monte Carlo systems EGSNRC, GEANT4, and PENELOPE were benchmarked against the published measurements using the revised beam energies. Monte Carlo simulation was capable of calculation of photon yield in the experimental geometry to 5% out to 30 degree sign , 10% at wider angles, and photon spectra to 10% at intermediate photon energies, 15% at lower energies. Accuracy of measured photon yield from 0 to 30 degree sign was 5%, 1 s.d., increasing to 7% for the larger angles. EGSNRC and PENELOPE results were within 2 s.d. of the measured photon yield at all beam energies and angles, GEANT4 within 3 s.d. Photon yield at nonzero angles for angles covering conventional field sizes used in radiotherapy (out to 10 degree sign ), measured with an accuracy of 3%, was calculated within 1 s.d. of measurement for EGSNRC, 2 s.d. for PENELOPE and GEANT4. Calculated spectra closely matched measurement at photon energies over 5 MeV. Photon spectra near 5 MeV were underestimated by as much as 10% by all three codes. The photon spectra below 2-3 MeV for the Be and Al targets and small angles were overestimated by up to 15% when using EGSNRC and PENELOPE, 20% with GEANT4. EGSNRC results with the NIST option for the bremsstrahlung cross section were preferred over the alternative cross section available in EGSNRC and over EGS4. GEANT4 results calculated with the &apos

  1. Total bremsstrahlung spectra of thick lead compounds produced by {sup 90}Sr beta emitter in photon energy region of 10–100 keV

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, Suhansar Jit [Department of Physics, B.B.S.B Polytechnic, Fatehgarh Sahib, Punjab (India); Singh, Tajinder, E-mail: tajindersingh2k9@gmail.com [Department of Physics, Mata Gujri College, Fatehgarh Sahib, Punjab (India); Singh, Doordarshi [Department of Mechanical Engineering, B.B.S.B Engineering College, Fatehgarh Sahib, Punjab (India); Singh, Amrit [Department of Physics, Baba Ajay Singh Khalsa College, Gurdas Nangal, Gurdaspur, Punjab (India); Dhaliwal, A.S. [Department of Physics, Sant Longowal Institute of Engineering & Technology, Longowal (Sangrur), Punjab (India)

    2017-06-15

    Highlights: • Total bremsstrahlung spectra in thick targets of Pb compounds by {sup 90}Sr in energy range 10–100 keV. • Experimental results show better agreement with the model which includes PB in SA up to 30 keV. • At higher photon energy region 30–100 keV the model which describes OB is more accurate. • Experimental results show positive deviations from the entire models at higher energy end spectrum. - Abstract: The total bremsstrahlung spectra in the thick targets of lead acetate trihydrate (Pb(CH{sub 3}COO){sub 2}·3H{sub 2}O), lead nitrate Pb(NO{sub 3}){sub 2} and lead chloride (PbCl{sub 2}) produced by {sup 90}Sr beta particles have been investigated in the photon energy region of 10–100 keV. The experimental bremsstrahlung spectra have been compared with the theoretical models Elwert corrected (non relativistic) Bethe Heitler theory, modified Elwert factor (relativistic) Bethe Heitler theory for ordinary bremsstrahlung and modified Elwert factor (relativistic) Bethe Heitler theory which includes polarization bremsstrahlung in the stripped atom approximation. The experimental results show better agreement with theoretical model that includes polarization bremsstrahlung in stripped approximation in the photon energy region below 30 keV. However, at higher photon energy region 30–100 keV, the theoretical model which describes ordinary bremsstrahlung is more accurate to describe the experimental bremsstrahlung spectra. The experimental results show positive deviations from the entire theoretical models at higher energy end of the spectrum. The results indicate that polarization bremsstrahlung plays important role in the formation of total bremsstrahlung spectra in lead compounds produced by continuous beta particles at low photon energy region of 10–30 keV.

  2. Polarization bremsstrahlung in α decay

    International Nuclear Information System (INIS)

    Amusia, M. Ya.; Zon, B. A.; Kretinin, I. Yu.

    2007-01-01

    A mechanism of formation of electromagnetic radiation that accompanies α decay and is associated with the emission of photons by electrons of atomic shells due to the scattering of α particles by these atoms (polarization bremsstrahlung) is proposed. It is shown that, when the photon energy is no higher than the energy of K electrons of an atom, polarization bremsstrahlung makes a significant contribution to the bremsstrahlung in α decay

  3. Electron - atom bremsstrahlung

    International Nuclear Information System (INIS)

    Kim, L.

    1986-01-01

    Features of bremsstrahlung radiation from neutral atoms and atoms in hot dense plasmas are studied. Predictions for the distributions of electron-atom bremsstrahlung radiation for both the point-Coulomb potential and screened potentials are obtained using a classical numerical method. Results agree with exact quantum-mechanical partial-wave results for low incident electron energies in both the point-Coulomb and screened potentials. In the screened potential, the asymmetry parameter of a spectrum is reduced from the Coulomb values. The difference increases with decreasing energy and begins to oscillate at very low energies. The scaling properties of bremsstrahlung spectra and energy losses were also studied. It was found that the ratio of the radiative energy loss for positrons to that for electrons obeys a simple scaling law, being expressible fairly accurately as a function only of the quantity T 1 /Z 2 . This scaling is exact in the case of the point-Coulomb potential, both for classical bremsstrahlung and for the nonrelativistic dipole Sommerfeld formula. Bremsstrahlung from atoms in hot dense plasmas were also studied describing the atomic potentials by the temperature-and-density dependent Thomas-Fermi mode. Gaunt factors were obtained with the relativistic partial-wave method for atoms in plasmas of various densities and temperatures

  4. Determination of the parametric region in which runaway electron energy losses are dominated by bremsstrahlung radiation in tokamaks

    International Nuclear Information System (INIS)

    Fernandez-Gomez, I.; Martin-Solis, J. R.; Sanchez, R.

    2007-01-01

    It has been recently argued that, at sufficiently large parallel electric fields, bremsstrahlung radiation can greatly reduce the maximum energy that runaway electrons can gain in tokamaks [M. Bakhtiari et al., Phys. Plasmas 12, 102503 (2005)]. In this contribution, the work of these authors is extended to show that the region where bremsstrahlung radiation dominate runaway energy losses is however more restricted than reported by them. Expressions will be provided for the limits of this region within the parameter space spanned by the background density and parallel electric field, as a function of the rest of the plasma parameters. It will be shown that the background density has to be above a certain critical value and that the parallel electric field must lie within a range of values, below and above which synchrotron radiation dominate the runaway energy losses. Finally, it will be demonstrated that typical disruption parameters lie within this region and, as a result, bremsstrahlung losses still play an important role in controlling the runaway energy

  5. Powerful accelerators for bremsstrahlung and electron beams generation on the basis of inductive energy-storage elements

    Energy Technology Data Exchange (ETDEWEB)

    Diyankov, V S; Kovalev, V P; Kormilitsin, A I; Lavrentev, B N [All-Russian Research Institute of Technical Physics, Snezhinsk (Russian Federation)

    1997-12-31

    The report summarizes RFNC-VNIITF activities from 1963 till 1995, devoted to the development of pulsed electron accelerators on the basis of inductive energy storage with electroexplosive wires. These accelerators are called IGUR. The activities resulted in the development of a series of generators of powerful radiation being cheap and easy in manufacturing and servicing. The accelerators achieved the following maximum parameters: diode voltage up to 6 MV, diode current up to 80 kA, current of the extracted electron beam 30 kA, density of the extracted electron beam energy 500 J/cm{sup 2}, bremsstrahlung dose 250000 Rads, and bremsstrahlung dose rate 10{sup 13} Rads/sec. (author). 3 tabs., 5 figs., 7 refs.

  6. Powerful accelerators for bremsstrahlung and electron beams generation on the basis of inductive energy-storage elements

    International Nuclear Information System (INIS)

    Diyankov, V.S.; Kovalev, V.P.; Kormilitsin, A.I.; Lavrentev, B.N.

    1996-01-01

    The report summarizes RFNC-VNIITF activities from 1963 till 1995, devoted to the development of pulsed electron accelerators on the basis of inductive energy storage with electroexplosive wires. These accelerators are called IGUR. The activities resulted in the development of a series of generators of powerful radiation being cheap and easy in manufacturing and servicing. The accelerators achieved the following maximum parameters: diode voltage up to 6 MV, diode current up to 80 kA, current of the extracted electron beam 30 kA, density of the extracted electron beam energy 500 J/cm 2 , bremsstrahlung dose 250000 Rads, and bremsstrahlung dose rate 10 13 Rads/sec. (author). 3 tabs., 5 figs., 7 refs

  7. Polarization of Bremsstrahlung

    International Nuclear Information System (INIS)

    Miller, J.

    1957-01-01

    The numerical results for the polarization of Bremsstrahlung are presented. The multiple scattering of electrons in the target is taken into account. The angular-and photon energy dependences are seen on the curves for an incident 25 MeV electron energy. (Author) [fr

  8. Thermal Bremsstrahlung probing nuclear multifragmentation in nucleus-nucleus collisions around the Fermi energy; Bremsstrahlung thermique comme sonde de la multifragmentation nucleaire dans les collisions noyau-noyau aux energies de Fermi

    Energy Technology Data Exchange (ETDEWEB)

    D' Enterria, D.G

    2000-05-15

    The thermodynamical properties of nuclear matter at moderate temperatures and densities, in the vicinity of the predicted nuclear liquid-gas phase transition, are studied using as experimental probe the hard-photons (E{sub {gamma}} > 30 MeV) emitted in nucleus-nucleus collisions. Photon and charged-particle production in four different heavy-ion reactions (Ar{sup 36} + Au{sup 197}, Ag{sup 107}, Ni{sup 58}, C{sup 12} at 60 A*MeV) is measured exclusively and inclusively coupling the TAPS photon spectrometer with two charged-particle and intermediate-mass-fragment detectors covering nearly 4{pi}. We confirm that Bremsstrahlung emission in first-chance (off-equilibrium) proton-neutron collisions (pn{gamma}) is the dominant origin of hard photons. We also firmly establish the existence of a thermal radiation component emitted in second-chance proton-neutron collisions. This thermal Bremsstrahlung emission takes place in semi-central and central nucleus-nucleus reactions involving heavy targets. We exploit this observation i) to demonstrate that thermal equilibrium is reached during the reaction, ii) to establish a new thermometer of nuclear matter based on Bremsstrahlung photons, iii) to derive the thermodynamical properties of the excited nuclear sources and, in particular, to establish a 'caloric curve' (temperature versus excitation energy), and iv) to assess the time-scales of the nuclear break-up process. (author)

  9. Excitation of spin-1 states in 166168170Er using bremsstrahlung

    International Nuclear Information System (INIS)

    Metzger, F.R.

    1976-01-01

    Some 40 states in 166 , 168 , 170 Er, most of them previously unknown, have been excited using bremsstrahlung with < or =4.2 MeV endpoint energy. For all but three of these levels, the angular distribution of the resonantly scattered radiation favors the assignment of spin 1. For some of the strongly excited levels, linear polarization measurements have been performed. They indicate that these levels have positive parity. The branching ratios further characterize them as K=1 excitations

  10. Model for bremsstrahlung emission accompanying interactions between protons and nuclei from low energies up to intermediate energies: Role of magnetic emission

    Science.gov (United States)

    Maydanyuk, Sergei P.

    2012-07-01

    A model of the bremsstrahlung emission which accompanies proton decay and collisions of protons off nuclei in the low- to intermediate-energy region has been developed. This model includes spin formalism, a potential approach for describing the interaction between protons and nuclei, and an emission that includes a component of the magnetic emission (defined on the basis of the Pauli equation). For the problem of bremsstrahlung during proton decay the role of magnetic emission is studied by using such a model. For the 146Tm nucleus the following has been studied: (1) How much does the magnetic emission change the full bremsstrahlung spectrum? (2) At which angle is the magnetic emission the most intensive relative to the electric emission? (3) Is there some spatial region where the magnetic emission increases strongly relative to the electric emission? (4) How intensive is the magnetic emission in the tunneling region? (5) Which is the maximal probability? Which value does it equal to at the zero-energy limit of the emitted photons? It is demonstrated that the model is able to describe well enough experimental data of bremsstrahlung emission which accompanies collisions of protons off 9C, 64Cu, and 107Ag nuclei at an incident energy of Tlab=72 MeV (at a photon energy up to 60 MeV) and off 9Be, 12C, and 208Pb nuclei at an incident energy of Tlab=140 MeV (at a photon energy up to 120 MeV).

  11. Black-hole bremsstrahlung and the efficiency of mass-energy radiative transfer

    International Nuclear Information System (INIS)

    Oliveira, H. P. de; Soares, I. Damiao; Tonini, E. V.

    2008-01-01

    We present results from numerical evolution of a boosted black hole, perturbed nonlinearly by an axisymmetric distribution of matter in the realm of Robinson-Trautman spacetimes. Characteristic initial data for the system were constructed and the Robinson-Trautmann equation was integrated for these data using a numerical code based on the Galerkin-collocation method. The emission of gravitational waves by the system is typical of bremsstrahlung at early times, a consequence of the deceleration of the black hole as it interacts with the perturbation; part of the perturbation is radiated away and another part is absorbed into the hole. The angular pattern evolves to the quadrupole form for later times. The final configuration is a black hole in motion with larger (Bondi) rest mass and smaller boost parameter. The efficiency Δ of mass-energy extraction by gravitational wave emission was also computed. The relation of Δ to the mass of the remnant black hole satisfies a nonextensive thermostatistics distribution with entropic index q≅1/2. The result extends analytical evaluations based on the linearized theory of gravitational wave emission. For each initial boost parameter, there always exists a (large) value of the perturbation parameter A 0 for which the momentum of the remnant black hole has opposite sign to that of the unperturbed black hole, due to the strong deceleration during the process of gravitational wave emission. The temporal wave form is that of an initial burst and we evaluate that for a large range of A 0 the process corresponds to a high power output in the initial dominant pulse.

  12. Neutron-proton bremsstrahlung from intermediate energy heavy-ion reactions as a probe of the nuclear symmetry energy?

    International Nuclear Information System (INIS)

    Yong, G.-C.; Li Baoan; Chen Liewen

    2008-01-01

    Hard photons from neutron-proton bremsstrahlung in intermediate energy heavy-ion reactions are examined as a potential probe of the nuclear symmetry energy within a transport model. Effects of the symmetry energy on the yields and spectra of hard photons are found to be generally smaller than those due to the currently existing uncertainties of both the in-medium nucleon-nucleon cross sections and the photon production probability in the elementary process pn→pnγ. Very interestingly, nevertheless, the ratio of hard photon spectra R 1/2 (γ) from two reactions using isotopes of the same element is not only approximately independent of these uncertainties but also quite sensitive to the symmetry energy. For the head-on reactions of 132 Sn + 124 Sn and 112 Sn + 112 Sn at E beam /A=50 MeV, for example, the R 1/2 (γ) displays a rise up to 15% when the symmetry energy is reduced by about 20% at ρ=1.3ρ 0 which is the maximum density reached in these reactions

  13. Calculation of energy and angular distributions of the bremsstrahlung of 10 MeV electrons bombarding a thick tungsten target

    International Nuclear Information System (INIS)

    Tsovbun, V.I.

    1977-01-01

    Computer calculations have been performed to extend the data available on energy and angular distribution of the 10 MeV electron bremsrahlung into a higher angle region. The ETRAN-16D program developed by R.G.Berger for calculation of electron-photon cascades passing through matter using computers IBM-360 and UNIVAC-1108 was modified to operate with the CDC-6500 computer. A brief summary of the program is provided. An angular distribution of the bremsstrahlung dose absorbed in the air has been also calculated. The results extended into the 90-180 deg region can be used to calculate the biological shield of electron accelerators

  14. The effect of magnetic field strength on the time evolution of high energy bremsstrahlung radiation created by an electron cyclotron resonance ion source

    Energy Technology Data Exchange (ETDEWEB)

    Ropponen, T. [Department of Physics, University of Jyvaeskylae, P.O. Box 35, FI-40014 (Finland)], E-mail: tommi.ropponen@phys.jyu.fi; Tarvainen, O. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Jones, P.; Peura, P.; Kalvas, T. [Department of Physics, University of Jyvaeskylae, P.O. Box 35, FI-40014 (Finland); Suominen, P. [Prizztech Ltd/Magnet Technology Centre, Tiedepuisto 4, FI-28600 Pori (Finland); Koivisto, H.; Arje, J. [Department of Physics, University of Jyvaeskylae, P.O. Box 35, FI-40014 (Finland)

    2009-03-11

    An electron cyclotron resonance (ECR) ion source is one of the most used ion source types for high charge state heavy ion production. In ECR plasma the electrons are heated by radio frequency microwaves in order to provide ionization of neutral gases. As a consequence, ECR heating also generates very high electron energies (up to MeV region) which can produce a vast amount of bremsstrahlung radiation causing problems with radiation shielding and heating superconducting cryostat of an ECR ion source. To gain information about the time evolution of the electron energies in ECR plasma radial bremsstrahlung measurements were performed. JYFL 14 GHz ECR ion source was operated in pulsed mode and time evolution measurements were done with different axial magnetic field strengths with oxygen and argon plasmas. Bremsstrahlung data were analyzed with a time interval of 2 ms yielding information at unprecedented detail about the time evolution of high energy bremsstrahlung radiation from an ECR ion source. It was observed, for example, that reaching the steady state phase of the plasma bremsstrahlung requires several hundred milliseconds and the steady state time can be different with different gases.

  15. Coherent bremsstrahlung in crystals as a tool for producing high energy photon beams to be used in photoproduction experiments at CERN SPS

    Energy Technology Data Exchange (ETDEWEB)

    Bilokon, H; D' Ettorre Piazzoli, B; Mannocchi, G [Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica; Istituto Nazionale di Fisica Nucleare, Frascati (Italy). Lab. Nazionale di Frascati); Bologna, G; Picchi, P [Turin Univ. (Italy). Ist. di Fisica Generale; Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica; Istituto Nazionale di Fisica Nucleare, Frascati (Italy). Lab. Nazionale di Frascati); Celani, F; Falcioni, R [Istituto Nazionale di Fisica Nucleare, Frascati (Italy). Lab. Nazionale di Frascati

    1983-01-01

    We recall the properties of coherent bremsstrahlung of high energy electrons in single crystals and show that a suitably oriented diamond crystal can produce a high energy bremsstrahlung beam whose quasimonochromatic spectral composition may be exploited for increasing the production rate in a photoproduction experiment at hundreds of GeV. A careful analysis of the required angular resolutions is performed. It turns out that the standard deviation of the electron beam angular divergence in one plane should be less than 0.3 mrad, for a beam energy of 150 GeV. The standard deviation in the perpendicular plane is not critical. In this situation the photoproduction rate in a typical case is increased by a factor of about 3 with respect to the conventional bremsstrahlung beam.

  16. Quantum electrodynamics of the internal source x-ray holographies: Bremsstrahlung, fluorescence, and multiple-energy x-ray holography

    International Nuclear Information System (INIS)

    Miller, G.A.; Sorensen, L.B.

    1997-01-01

    Quantum electrodynamics (QED) is used to derive the differential cross sections measured in the three new experimental internal source ensemble x-ray holographies: bremsstrahlung (BXH), fluorescence (XFH), and multiple-energy (MEXH) x-ray holography. The polarization dependence of the BXH cross section is also obtained. For BXH, we study analytically and numerically the possible effects of the virtual photons and electrons which enter QED calculations in summing over the intermediate states. For the low photon and electron energies used in the current experiments, we show that the virtual intermediate states produce only very small effects. This is because the uncertainty principle limits the distance that the virtual particles can propagate to be much shorter than the separation between the regions of high electron density in the adjacent atoms. We also find that using the asymptotic form of the scattering wave function causes about a 5 10% error for near forward scattering. copyright 1997 The American Physical Society

  17. Study of 1s internal bremsstrahlung spectrum from 57Co

    Science.gov (United States)

    Raghavendra, M. K.; Azeez, Syed; Ramaswamy, C. R.; Umesh, T. K.; Gowda, Ramakrishna

    2002-07-01

    The internal bremsstrahlung contribution from the electron capture of 57Co has been measured in coincidence with K-X-ray of the residual atom. The end-point energy (EPE) is extracted from the data using the linearised Jauch plot. The transition energy obtained using the (EPE) is 842.7 keV, which is close to the value given by Audi and Wapstra. The measured intensity and shape factor from 300 to 600 keV are found to be in good agreement with the Glauber and Martin theory.

  18. Study of 1s internal bremsstrahlung spectrum from 57Co

    International Nuclear Information System (INIS)

    Raghavendra, M.K.; Azeez, Syed; Ramaswamy, C.R.; Umesh, T.K.; Gowda, Ramakrishna

    2002-01-01

    The internal bremsstrahlung contribution from the electron capture of 57 Co has been measured in coincidence with K-X-ray of the residual atom. The end-point energy (EPE) is extracted from the data using the linearised Jauch plot. The transition energy obtained using the (EPE) is 842.7 keV, which is close to the value given by Audi and Wapstra. The measured intensity and shape factor from 300 to 600 keV are found to be in good agreement with the Glauber and Martin theory

  19. Fission of intermediate mass nuclei by bremsstrahlung photons in the energy range 0.8-1.8 GeV

    International Nuclear Information System (INIS)

    Lima, D.A. de.

    1983-01-01

    The fission of intermediate mass nuclei in the Al-Ta internal induced by bremsstrahlung photons of maximum energies between 0,8 to 1,8 GeV is studied. Thin targets of Nd and Sm and dense targets of Al,Ti,Co,Zr,Nb,Ag,In and Ta are utilized, and all the aspects related with the fission fragment absorption by the targets themselves are considered. The samples are exposed in th 2,5 GeV Electron Synchrotron at Bonn University. Muscovite mica, CR-39 and makrofol are used as fission fragments detectors. Fission cross sections and nuclear fissionabilities of the studied elements are estimated. (L.C.) [pt

  20. Comparison of Classical and Quantum Bremsstrahlung

    International Nuclear Information System (INIS)

    Pratt, R.H.; Uskov, D.B.; Korol, A.V.; Obolensky, O.I.

    2003-01-01

    Classical features persist in bremsstrahlung at surprisingly high energies, while quantum features are present at low energies. For Coulomb bremsstrahlung this is related to the similar properties of Coulomb scattering. For bremsstrahlung in a screened potential, the low energy spectrum and angular distribution exhibit structures. In quantum mechanics these structures are associated with zeroes of particular angular-momentum transfer matrix elements at particular energies, a continuation of the Cooper minima in atomic photoeffect. They lead to transparency windows in free-free absorption. The trajectories of these zeroes in the plane of initial and final transition energies (bound and continuum) has been explored. Corresponding features have now been seen in classical bremsstrahlung, resulting from reduced contributions from particular impact parameters at particular energies. This has suggested the possibility of a more unified treatment of classical and quantum bremsstrahlung, based on the singularities of the scattering amplitude in angular momentum

  1. Calculation of Bremsstrahlung yield for thin target

    International Nuclear Information System (INIS)

    Demir, N.; Akkurt, I.; Tekin, H. O.; Cakirli, R. B.; Akkus, B.; Kupa, I.

    2010-01-01

    The Bremsstrahlung photon is created by de-accelerating electron beam in an electric field which is usually a thin material so-called radiator. The obtained Bremsstrahlung yield depends on some parameter such as incoming electron beam energy, the thickness and also Z number of the radiator. The main aim of this work is to obtain optimum radiator to be used at Bremsstrahlung photon beam facility at TAC. For this purposes the Bremsstrahlung photon yield has been obtained using FLUKA code for different types materials.

  2. Free Energy, Enthalpy and Entropy from Implicit Solvent End-Point Simulations.

    Science.gov (United States)

    Fogolari, Federico; Corazza, Alessandra; Esposito, Gennaro

    2018-01-01

    Free energy is the key quantity to describe the thermodynamics of biological systems. In this perspective we consider the calculation of free energy, enthalpy and entropy from end-point molecular dynamics simulations. Since the enthalpy may be calculated as the ensemble average over equilibrated simulation snapshots the difficulties related to free energy calculation are ultimately related to the calculation of the entropy of the system and in particular of the solvent entropy. In the last two decades implicit solvent models have been used to circumvent the problem and to take into account solvent entropy implicitly in the solvation terms. More recently outstanding advancement in both implicit solvent models and in entropy calculations are making the goal of free energy estimation from end-point simulations more feasible than ever before. We review briefly the basic theory and discuss the advancements in light of practical applications.

  3. Free Energy, Enthalpy and Entropy from Implicit Solvent End-Point Simulations

    Directory of Open Access Journals (Sweden)

    Federico Fogolari

    2018-02-01

    Full Text Available Free energy is the key quantity to describe the thermodynamics of biological systems. In this perspective we consider the calculation of free energy, enthalpy and entropy from end-point molecular dynamics simulations. Since the enthalpy may be calculated as the ensemble average over equilibrated simulation snapshots the difficulties related to free energy calculation are ultimately related to the calculation of the entropy of the system and in particular of the solvent entropy. In the last two decades implicit solvent models have been used to circumvent the problem and to take into account solvent entropy implicitly in the solvation terms. More recently outstanding advancement in both implicit solvent models and in entropy calculations are making the goal of free energy estimation from end-point simulations more feasible than ever before. We review briefly the basic theory and discuss the advancements in light of practical applications.

  4. Muscle Synergies Heavily Influence the Neural Control of Arm Endpoint Stiffness and Energy Consumption.

    Science.gov (United States)

    Inouye, Joshua M; Valero-Cuevas, Francisco J

    2016-02-01

    Much debate has arisen from research on muscle synergies with respect to both limb impedance control and energy consumption. Studies of limb impedance control in the context of reaching movements and postural tasks have produced divergent findings, and this study explores whether the use of synergies by the central nervous system (CNS) can resolve these findings and also provide insights on mechanisms of energy consumption. In this study, we phrase these debates at the conceptual level of interactions between neural degrees of freedom and tasks constraints. This allows us to examine the ability of experimentally-observed synergies--correlated muscle activations--to control both energy consumption and the stiffness component of limb endpoint impedance. In our nominal 6-muscle planar arm model, muscle synergies and the desired size, shape, and orientation of endpoint stiffness ellipses, are expressed as linear constraints that define the set of feasible muscle activation patterns. Quadratic programming allows us to predict whether and how energy consumption can be minimized throughout the workspace of the limb given those linear constraints. We show that the presence of synergies drastically decreases the ability of the CNS to vary the properties of the endpoint stiffness and can even preclude the ability to minimize energy. Furthermore, the capacity to minimize energy consumption--when available--can be greatly affected by arm posture. Our computational approach helps reconcile divergent findings and conclusions about task-specific regulation of endpoint stiffness and energy consumption in the context of synergies. But more generally, these results provide further evidence that the benefits and disadvantages of muscle synergies go hand-in-hand with the structure of feasible muscle activation patterns afforded by the mechanics of the limb and task constraints. These insights will help design experiments to elucidate the interplay between synergies and the mechanisms

  5. A novel nuclear pyrometry for the characterization of high-energy bremsstrahlung and electrons produced in relativistic laser-plasma interactions

    International Nuclear Information System (INIS)

    Guenther, M. M.; Sonnabend, K.; Harres, K.; Roth, M.; Brambrink, E.; Vogt, K.; Bagnoud, V.

    2011-01-01

    We present a novel nuclear activation-based method for the investigation of high-energy bremsstrahlung produced by electrons above 7 MeV generated by a high-power laser. The main component is a novel high-density activation target that is a pseudo alloy of several selected isotopes with different photo-disintegration reaction thresholds. The gamma spectrum emitted by the activated targets is used for the reconstruction of the bremsstrahlung spectrum using an analysis method based on Penfold and Leiss. This nuclear activation-based technique allows for the determination of the number of bremsstrahlung photons per energy bin in a wide range energy without any anticipated fit procedures. Furthermore, the analysis method also allows for the determination of the absolute yield, the energy distribution, and the temperature of high-energy electrons at the relativistic laser-plasma interaction region. The pyrometry is sensitive to energies above 7 MeV only, i.e., this diagnostic is insensitive to any low-energy processes.

  6. A novel nuclear pyrometry for the characterization of high-energy bremsstrahlung and electrons produced in relativistic laser-plasma interactions

    Energy Technology Data Exchange (ETDEWEB)

    Guenther, M. M.; Sonnabend, K.; Harres, K.; Roth, M. [Institut fuer Kernphysik, Schlossgartenstr. 9, Technische Universitaet Darmstadt, D-64289 Darmstadt (Germany); Brambrink, E. [Laboratoire pour l' Utilisation des Lasers Intenses, UMR 7605 CNRS-CEA-Ecole Polytechnique-Universite Paris VI, F-91128 Palaiseau (France); Vogt, K.; Bagnoud, V. [GSI - Helmholtzzentrum fuer Schwerionenforschung GmbH, Planckstr. 1, D-64291 Darmstadt (Germany)

    2011-08-15

    We present a novel nuclear activation-based method for the investigation of high-energy bremsstrahlung produced by electrons above 7 MeV generated by a high-power laser. The main component is a novel high-density activation target that is a pseudo alloy of several selected isotopes with different photo-disintegration reaction thresholds. The gamma spectrum emitted by the activated targets is used for the reconstruction of the bremsstrahlung spectrum using an analysis method based on Penfold and Leiss. This nuclear activation-based technique allows for the determination of the number of bremsstrahlung photons per energy bin in a wide range energy without any anticipated fit procedures. Furthermore, the analysis method also allows for the determination of the absolute yield, the energy distribution, and the temperature of high-energy electrons at the relativistic laser-plasma interaction region. The pyrometry is sensitive to energies above 7 MeV only, i.e., this diagnostic is insensitive to any low-energy processes.

  7. Proton-proton bremsstrahlung

    International Nuclear Information System (INIS)

    Fearing, H.W.

    1990-01-01

    We summarize some of the information about the nucleon-nucleon force which has been obtained by comparing recent calculations of proton-proton bremsstrahlung with cross section and analyzing power data from the new TRIUMF bremsstrahlung experiment. Some comments are made as to how these results can be extended to neutron-proton bremsstrahlung. (Author) 17 refs., 6 figs

  8. Polarizational radiation or 'atomic' bremsstrahlung

    International Nuclear Information System (INIS)

    Ya Amusia, M.

    1992-01-01

    It is demonstrated that a new kind of continuum spectrum radiation exists, where the mechanism of formation is quite different from that of ordinary bremsstrahlung. The latter originates due to slowing down of the charged projectile in the target field, while the former, called polarization radiation or 'atomic' bremsstrahlung, is a result of radiation either of the target or the projectile particles dipolarly polarized during the collision process. Not only general formulae, but also results of concrete calculations are presented. These demonstrate, that for electron-atom collisions the atomic contribution to the total bremsstrahlung spectrum becomes dominant for photon energies near and above the atomic ionization potential. As to atom-atom or ion-atom collisions, the bremsstrahlung spectrum is completely determined by the atomic contribution. The specific features of the case when the incoming particles are relativistic are discussed at length. A number of examples of colliding pairs are considered, for which the atomic bremsstrahlung process is quite essential: A bare nucleus and an atom, pair of atoms, at least one of which is excited, electron, or atom interacting with a molecule. The same mechanism is essential also in formation of radiation in nuclear and elementary particle collisions. (orig.)

  9. Use of spectrophotometric readout method for free radical dosimetry in radiation processing including low energy electrons and bremsstrahlung

    International Nuclear Information System (INIS)

    Gupta, B.L.

    2000-01-01

    Our laboratory maintains standards for high doses in India. The glutamine powder dosimeter (spectrophotometric readout) is used for this purpose. Present studies show that 20 mg of unirradiated/irradiated glutamine dissolved in freshly prepared 10 ml of aerated aqueous acidic FX solution containing 2 x 10 -3 mol dm -3 ferrous ammonium sulphate and 10 -4 mol dm -3 xylenol orange in 0.033 mol dm -3 sulphuric acid is suitable for the dosimetry in the dose range of 0.1-100 kGy. Normally no corrections are required for the post-irradiation fading of the irradiated glutamine. The response of glutamine dosimeter is independent of irradiation temperature in the range of about 23-30 deg. C and at other temperatures, a correction is necessary. The dose intercomparison results for photon, electron and bremsstrahlung radiations show that glutamine can be used as a reference standard dosimeter. The use of flat polyethylene bags containing glutamine powder has proved very successful for electron dosimetry of wide energies. Several other amino acids like alanine, valine and threonine can also be used to cover wide range of doses using spectrophotometric readout method. (author)

  10. Energy metabolism and biotransformation as endpoints to pre-screen hepatotoxicity using a liver spheroid model

    International Nuclear Information System (INIS)

    Xu Jinsheng; Purcell, Wendy M.

    2006-01-01

    The current study investigated liver spheroid culture as an in vitro model to evaluate the endpoints relevant to the status of energy metabolism and biotransformation after exposure to test toxicants. Mature rat liver spheroids were exposed to diclofenac, galactosamine, isoniazid, paracetamol, m-dinitrobenzene (m-DNB) and 3-nitroaniline (3-NA) for 24 h. Pyruvate uptake, galactose biotransformation, lactate release and glucose secretion were evaluated after exposure. The results showed that pyruvate uptake and lactate release by mature liver spheroids in culture were maintained at a relatively stable level. These endpoints, together with glucose secretion and galactose biotransformation, were related to and could reflect the status of energy metabolism and biotransformation in hepatocytes. After exposure, all of the test agents significantly reduced glucose secretion, which was shown to be the most sensitive endpoint of those evaluated. Diclofenac, isoniazid, paracetamol and galactosamine reduced lactate release (P < 0.01), but m-DNB increased lactate release (P < 0.01). Diclofenac, isoniazid and paracetamol also reduced pyruvate uptake (P < 0.01), while galactosamine had little discernible effect. Diclofenac, galactosamine, paracetamol and m-DNB also reduced galactose biotransformation (P < 0.01), by contrast, isoniazid did not. The metabolite of m-DNB, 3-NA, which served as a negative control, did not cause significant changes in lactate release, pyruvate uptake or galactose biotransformation. It is concluded that pyruvate uptake, galactose biotransformation, lactate release and glucose secretion can be used as endpoints for evaluating the status of energy metabolism and biotransformation after exposure to test agents using the liver spheroid model to pre-screen hepatotoxicity

  11. Angular distribution of thick-target bremsstrahlung produced by electrons with initial energies ranging from 10 to 20 keV incident on Ag

    Energy Technology Data Exchange (ETDEWEB)

    Gonzales, D.; Cavness, B.; Williams, S. [Department of Physics, Angelo State University, San Angelo, Texas 76909 (United States)

    2011-11-15

    Experimental results are presented comparing the intensities of the bremsstrahlung produced by electrons with initial energies ranging from 10 to 20 keV incident on a thick Ag target, measured at forward angles in the range of 0 degree sign to 55 degree sign . When the data are corrected for attenuation due to photon absorption within the target, the results indicate that the detected radiation is distributed anisotropically only at photon energies k that are approximately equal to the initial energy of the incident electrons E{sub 0}. The results of our experiments suggest that, as k/E{sub 0}{yields} 0, the detected radiation essentially becomes isotropic due primarily to the scattering of electrons within the target. A comparison to the theory of Kissel et al.[At. Data Nucl. Data Tables 28, 381 (1983)] suggests that the angular distribution of bremsstrahlung emitted by electrons incident on thick targets is similar to the angular distribution of bremsstrahlung emitted by electrons incident on free-atom targets only when k/E{sub 0}{approx_equal} 1. The experimental data also are in approximate agreement with the angular distribution predictions of the Monte Carlo program penelope.

  12. Pion-proton bremsstrahlung

    International Nuclear Information System (INIS)

    Liou, M.K.; Nutt, W.T.

    1978-01-01

    A method for applying the soft-photon theorem to bremsstrahlung is described and a detailed derivation of the formulae for π + -p bremsstrahlung is presented. The consistent treatment of the expansion of the bremsstrahlung cross-section around k=0 results in excellent fits to the experimental data. The data are consistent with small off-shell effects and no radiation from the Δ(1236) resonance

  13. State special standard for bremsstrahlung energy flux unit in the range of maximum photon energy 0.8-8.0 pJ (5-50 MeV)

    International Nuclear Information System (INIS)

    Yudin, M.F.; Skotnikov, V.V.; Bruj, V.N.; Tsvetkov, I.I.; Fominykh, V.I.

    1976-01-01

    The state special standard is described, which improves the accuracy and ensures unification and correctness of measurements of a bremsstrahlung energy flux. The size of the unit is conveyed, by means of working standards and model measuring means, to working devices measuring the energy flux over a wide range

  14. Equivalent half-value thickness and mean energies of filtered X-ray bremsstrahlung spectra

    International Nuclear Information System (INIS)

    Seelentag, W.W.; Panzer, W.

    1980-01-01

    X-ray beam qualities are often conveniently described by half-value thicknesses (in connection with tube voltage and filtration). Aluminium and copper are commonly used as half-value thickness materials, and either material may be used in a large intermediate energy range. Data comparisons frequently require conversions from values in Al to values in Cu. Equivalent half-value thicknesses for polychromatic radiations depend on the shapes of the spectra, but spectrometry is too expensive for routine application. Half-value thicknesses in both Al and Cu have been determined for some 250 spectra (tube potentials 10 to 300 kV). The results are tabulated, and these results together with a nomogram enable conversion with an accuracy of better than +- 5% in most cases. (UK)

  15. Bremsstrahlung: an experimentalists personal perspective on the post modern era

    International Nuclear Information System (INIS)

    Quarles, C.A.

    2000-01-01

    In this brief review I will discuss the recent experimental work on the doubly differential cross section, i.e. the photon energy and angular distribution, for electron Bremsstrahlung from thin solid film and gas targets. Since the beginning of the modern era in the study of Bremsstrahlung with the publication of the 1971 paper by Ts eng and Pratt, Professor Pratt has been the dominant influence in Bremsstrahlung research. Most, if not all, experimental research during the modern era has been motivated by the interest in comparing data with the theory of Pratt and his coworkers. As Bremsstrahlung research has moved into its post modern era, new experiments with increasing precision are concentrating on determining under what conditions ordinary Bremsstrahlung theory needs to be supplemented by a contribution from polarization Bremsstrahlung. Efforts to improve the comparison of thin-target experiment with theory have also led to new experimental and modeling work on Bremsstrahlung from thick solid targets. Thick-target Bremsstrahlung is interesting in its own right, but we also want to understand it better since it is the ever-present background in the thin-target experiments and the limiting factor in the effort to distinguish the polarization contribution to the total Bremsstrahlung spectrum. Professor Pratt ushered in the modern era in Bremsstrahlung research and has recently guided the transition into the post modern era. It can be expected that he will continue to have a formative influence on the developments of Bremsstrahlung research into the foreseeable future.

  16. Bremsstrahlung and neutral currents

    International Nuclear Information System (INIS)

    Ellis, R.G.; McKellar, B.H.J.

    1979-01-01

    The utility of the bremsstrahlung process in detecting parity violations from V-A weak neutral current interference is analysed in two ways. Firstly, bremsstrahlung from polarized lepton-nucleus scattering has an asymmetry with respect to the polarization of the incident leptons, and secondly, bremsstrahlung from unpolarized lepton nucleus scattering has a small circular polarization. The magnitude of each effect is calculated. The ratio of the parity violating contribution and the parity conserving contribution to the cross section is shown to be a misleading measure of the utility of these experiments. A parameter, the figure of merit, is introduced and used to discuss the feasibility of possible experiments

  17. CaFE: a tool for binding affinity prediction using end-point free energy methods.

    Science.gov (United States)

    Liu, Hui; Hou, Tingjun

    2016-07-15

    Accurate prediction of binding free energy is of particular importance to computational biology and structure-based drug design. Among those methods for binding affinity predictions, the end-point approaches, such as MM/PBSA and LIE, have been widely used because they can achieve a good balance between prediction accuracy and computational cost. Here we present an easy-to-use pipeline tool named Calculation of Free Energy (CaFE) to conduct MM/PBSA and LIE calculations. Powered by the VMD and NAMD programs, CaFE is able to handle numerous static coordinate and molecular dynamics trajectory file formats generated by different molecular simulation packages and supports various force field parameters. CaFE source code and documentation are freely available under the GNU General Public License via GitHub at https://github.com/huiliucode/cafe_plugin It is a VMD plugin written in Tcl and the usage is platform-independent. tingjunhou@zju.edu.cn. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  18. A method for energy window optimization for quantitative tasks that includes the effects of model-mismatch on bias: application to Y-90 bremsstrahlung SPECT imaging

    International Nuclear Information System (INIS)

    Rong Xing; Du Yong; Frey, Eric C

    2012-01-01

    Quantitative Yttrium-90 ( 90 Y) bremsstrahlung single photon emission computed tomography (SPECT) imaging has shown great potential to provide reliable estimates of 90 Y activity distribution for targeted radionuclide therapy dosimetry applications. One factor that potentially affects the reliability of the activity estimates is the choice of the acquisition energy window. In contrast to imaging conventional gamma photon emitters where the acquisition energy windows are usually placed around photopeaks, there has been great variation in the choice of the acquisition energy window for 90 Y imaging due to the continuous and broad energy distribution of the bremsstrahlung photons. In quantitative imaging of conventional gamma photon emitters, previous methods for optimizing the acquisition energy window assumed unbiased estimators and used the variance in the estimates as a figure of merit (FOM). However, for situations, such as 90 Y imaging, where there are errors in the modeling of the image formation process used in the reconstruction there will be bias in the activity estimates. In 90 Y bremsstrahlung imaging this will be especially important due to the high levels of scatter, multiple scatter, and collimator septal penetration and scatter. Thus variance will not be a complete measure of reliability of the estimates and thus is not a complete FOM. To address this, we first aimed to develop a new method to optimize the energy window that accounts for both the bias due to model-mismatch and the variance of the activity estimates. We applied this method to optimize the acquisition energy window for quantitative 90 Y bremsstrahlung SPECT imaging in microsphere brachytherapy. Since absorbed dose is defined as the absorbed energy from the radiation per unit mass of tissues in this new method we proposed a mass-weighted root mean squared error of the volume of interest (VOI) activity estimates as the FOM. To calculate this FOM, two analytical expressions were derived for

  19. A method for energy window optimization for quantitative tasks that includes the effects of model-mismatch on bias: application to Y-90 bremsstrahlung SPECT imaging.

    Science.gov (United States)

    Rong, Xing; Du, Yong; Frey, Eric C

    2012-06-21

    Quantitative Yttrium-90 ((90)Y) bremsstrahlung single photon emission computed tomography (SPECT) imaging has shown great potential to provide reliable estimates of (90)Y activity distribution for targeted radionuclide therapy dosimetry applications. One factor that potentially affects the reliability of the activity estimates is the choice of the acquisition energy window. In contrast to imaging conventional gamma photon emitters where the acquisition energy windows are usually placed around photopeaks, there has been great variation in the choice of the acquisition energy window for (90)Y imaging due to the continuous and broad energy distribution of the bremsstrahlung photons. In quantitative imaging of conventional gamma photon emitters, previous methods for optimizing the acquisition energy window assumed unbiased estimators and used the variance in the estimates as a figure of merit (FOM). However, for situations, such as (90)Y imaging, where there are errors in the modeling of the image formation process used in the reconstruction there will be bias in the activity estimates. In (90)Y bremsstrahlung imaging this will be especially important due to the high levels of scatter, multiple scatter, and collimator septal penetration and scatter. Thus variance will not be a complete measure of reliability of the estimates and thus is not a complete FOM. To address this, we first aimed to develop a new method to optimize the energy window that accounts for both the bias due to model-mismatch and the variance of the activity estimates. We applied this method to optimize the acquisition energy window for quantitative (90)Y bremsstrahlung SPECT imaging in microsphere brachytherapy. Since absorbed dose is defined as the absorbed energy from the radiation per unit mass of tissues in this new method we proposed a mass-weighted root mean squared error of the volume of interest (VOI) activity estimates as the FOM. To calculate this FOM, two analytical expressions were

  20. Beta induced Bremsstrahlung dose rate in concrete shielding

    International Nuclear Information System (INIS)

    Manjunatha, H.C.

    2013-01-01

    Dosimetric study of beta-induced Bremsstrahlung in concrete is importance in the field of radiation protection. The efficiency, intensity and dose rate of beta induced Bremsstrahlung by 113 pure beta nuclides in concrete shielding is computed. The Bremsstrahlung dosimetric parameters such as the efficiency (yield), Intensity and dose rate of Bremsstrahlung are low for 199 Au and high for 104 Tc in concrete. The efficiency, Intensity and dose rate of Bremsstrahlung increases with maximum energy of beta nuclide (Emax) and modified atomic number (Zmod) of the target. The estimated Bremsstrahlung efficiency, Intensity and dose rate are useful in the calculations photon track-length distributions. These parameters are useful to determine the quality and quantity of the radiation (known as the source term). Precise estimation of this source term is very important in planning of radiation shielding. (author)

  1. Using Poisson-regularized inversion of Bremsstrahlung emission to extract full electron energy distribution functions from x-ray pulse-height detector data

    Science.gov (United States)

    Swanson, C.; Jandovitz, P.; Cohen, S. A.

    2018-02-01

    We measured Electron Energy Distribution Functions (EEDFs) from below 200 eV to over 8 keV and spanning five orders-of-magnitude in intensity, produced in a low-power, RF-heated, tandem mirror discharge in the PFRC-II apparatus. The EEDF was obtained from the x-ray energy distribution function (XEDF) using a novel Poisson-regularized spectrum inversion algorithm applied to pulse-height spectra that included both Bremsstrahlung and line emissions. The XEDF was measured using a specially calibrated Amptek Silicon Drift Detector (SDD) pulse-height system with 125 eV FWHM at 5.9 keV. The algorithm is found to out-perform current leading x-ray inversion algorithms when the error due to counting statistics is high.

  2. The TAC Radiation Source for Bremsstrahlung Application

    International Nuclear Information System (INIS)

    Demir, N.

    2008-01-01

    The TAC is a project for the first Turkish radiation source and currently design study is produced with funding from the DPT (State Planning Unity). Two main part of the project will be IR-FEL and Bremsstrahlung facility. Each LINAC will provide max. electron energy of 20 MeV. The Bremsstrahlung facility at TAC will consist two of the LINAC module and will be obtained 35 MeV photon energy. This would provide a chance to investigate nuclear structure at this energy range and also some application of photonuclear physics. In this work the main parameter and plans for those of facility will be detailed

  3. Studies of internal bremsstrahlung spectrum of 35S beta emitter in the photon energy region of 1–100 keV

    International Nuclear Information System (INIS)

    Singh, Amrit; Dhaliwal, A.S.

    2014-01-01

    The internal bremsstrahlung (IB) spectral photon distribution, produced by soft beta particles of 35 S (W max =164 keV), in the photon energy region of 1–100 keV, is measured by using a Si(Li) detector, having high energy resolution and efficiency at low energy region. The measured spectral IB photon distribution is compared with KUB theory and Coulomb corrected IB theories given by Nilsson, and Lewis and Ford. After applying the necessary corrections, the experimental and theoretical IB spectral photon distributions are compared in terms of the number of IB photon of energy k per m o c 2 per unit photon yield. In the low energy region (below 10 keV), the experimental results are in agreement with all the theories. However, in photon energy region of 10–50 keV, experimental results are in agreement with Coulomb corrected Nilsson theory only, within the experimental errors. Further, beyond 50 keV, the Nilsson theory is more close to the experimental results than the KUB, and the Lewis and Ford theories. Hence, the Nilsson theory is more accurate than the other theories given by KUB and Lewis and Ford, particularly at a high energy end. The experimental results reported here with Si(Li) detector are free from number of ambiguities in earlier measurements reported with NaI(Tl) and HPGe detectors. The present results are indicating a relook into the theoretical considerations, given by different theories, while taking into account the Coulomb corrections for predicting the IB spectrum, particularly at high photon energy region. - Highlights: • The internal bremsstrahlung spectrum of 35 S beta emitter, in the photon energy region of 1–100 keV. • These measurement are taken by using a Si(Li) detector. • Theoretical and experimental results are reported in terms of number of photons of energy k per m 0 c 2 per unit photon yield. • The Nilsson theory for IB is more accurate than KUB and Lewis and Ford, particularly at high photon energy region

  4. Electron and bremsstrahlung penetration and dose calculation

    Science.gov (United States)

    Watts, J. W., Jr.; Burrell, M. O.

    1972-01-01

    Various techniques for the calculation of electron and bremsstrahlung dose deposition are described. Energy deposition, transmission, and reflection coefficients for electrons incident on plane slabs are presented, and methods for their use in electron dose calculations were developed. A method using the straight-ahead approximation was also developed, and the various methods were compared and found to be in good agreement. Both accurate and approximate methods of calculating bremsstrahlung dose were derived and compared. Approximation is found to give a good estimate of dose where the electron spectrum falls off exponentially with energy.

  5. The Cherenkov Bremsstrahlung

    International Nuclear Information System (INIS)

    Strel'tsov, V.N.

    1995-01-01

    The vanishing of the 'retardation factor' leads to a significant growth of the intensity of the electromagnetic field 'velocity part' of the moving charge. The Cherenkov radiation is its physical consequence. The same reason also conditions the growth of another term: the 'acceleration part' of the field which gives rise to the 'Cherenkov Bremsstrahlung'. 4 refs

  6. Bremsstrahlung from relativistic heavy ions in matter

    DEFF Research Database (Denmark)

    Sørensen, Allan Hvidkjær

    2010-01-01

    The emission of electromagnetic radiation by relativistic bare heavy ions penetrating ordinary matter is investigated. Our main aim is to determine the bremsstrahlung which we define as the radiation emitted when the projectile does not break up. It pertains to collisions without nuclear contact....... As a result of its relative softness, bremsstrahlung never dominates the energy-loss process for heavy ions. As to the emission of electromagnetic radiation in collisions with nuclear break-up, it appears modest when pertaining to incoherent action of the projectile nucleons in noncontact collisions...

  7. Coherent Bremsstrahlung, Coherent Pair Production, Birefringence and Polarimetry in the 20-170 GeV energy range using aligned crystals

    CERN Document Server

    Apyan, A; Badelek, B; Ballestrero, S; Biino, C; Birol, I; Cenci, P; Connell, S H; Eichblatt, S; Fonseca, T; Freund, A; Gorini, B; Groess, R; Ispirian, K; Ketel, T; Kononets, Y V; López, A; Mangiarotti, A; Sellschop, J P Friedel; Shieh, M; Sona, P; Strakhovenko, V M; Uggerhøj, U; Uggerhøj, Erik; Van Rens, B; Velasco, M; Vilakazi, Z Z; Wessely, O; Ünel, G; Kononets, Yu V

    2008-01-01

    The processes of coherent bremsstrahlung (CB) and coherent pair production (CPP) based on aligned crystal targets have been studied in the energy range 20-170 GeV. The experimental arrangement allowed these phenomena as well as their polarization dependence to be evaluated under conditions where single-photon cross-sections could be measured. This proved very important as the theoretical description of CB and CPP is an area of active theoretical debate and development. The theoretical approach used in this paper predicts both the cross sections and polarization observables very well for the experimental conditions investigated, indicating that the understanding of CB and CPP is reliable up to energies of 170 GeV. A birefringence effect in CPP was studied and it was demonstrated this enabled new technologies for high energy photon beam optics, such as polarimeters (for both linear and circular polarization) and phase plates. We also present new results regarding the features of coherent high energy photon emis...

  8. Nonlinear effects on bremsstrahlung emission in dusty plasmas

    International Nuclear Information System (INIS)

    Kim, Young-Woo; Jung, Young-Dae

    2004-01-01

    Nonlinear effects on the bremsstrahlung process due to ion-dust grain collisions are investigated in dusty plasmas. The nonlinear screened interaction potential is applied to obtain the Fourier coefficients of the force acting on the dust grain. The classical trajectory analysis is applied to obtain the differential bremsstrahlung radiation cross section as a function of the scaled impact parameter, projectile energy, photon energy, and Debye length. The result shows that the nonlinear effects suppress the bremsstrahlung radiation cross section due to collisions of ions with positively charged dust grains. These nonlinear effects decrease with increasing Debye length and temperature, and increase with increasing radiation photon energy

  9. Multiphoton polarization Bremsstrahlung effect

    International Nuclear Information System (INIS)

    Golovinskij, P.A.

    2001-01-01

    A general approach to induced polarization effects was formulated on the basis of theory of many particles in a strong periodic field. Correlation with the perturbation theory is shown and the types of effective polarization potentials both for isolated atoms and ions, and for ions in plasma, are provided. State of art in the theory of forced polarization Bremsstrahlung effect is analyzed and some outlooks for further experimental and theoretical studies are outlined [ru

  10. Internal bremsstrahlung spectra of the allowed. beta. emitters /sup 32/P, /sup 35/S and /sup 45/Ca

    Energy Technology Data Exchange (ETDEWEB)

    Powar, M S; Singh, M [Punjabi Univ., Patiala (India). Dept. of Physics

    1976-01-01

    A study of Coulomb field effects in internal bremsstrahlung (IB) has been undertaken by measuring the IB spectra for the allowed beta emitters /sup 32/P, /sup 35/S and /sup 45/Ca in the photon energy intervals of 50 to 1600 keV, 25 to 150 keV and 30 to 240 keV respectively. The experimental results show increasing positive departures from the KUB and Coulomb-corrected theories of Lewis and Ford, and Nilsson, with decreasing beta end-point energy. In the case of /sup 35/S the experimental results are 40 % higher than the more exact theory of Struzynski and Pollock for this isotope.

  11. Post-Newtonian gravitational bremsstrahlung

    International Nuclear Information System (INIS)

    Turner, M.; Will, C.M.

    1978-01-01

    We present formulae and numerical results for the gravitational radiation emitted during a low-deflection encounter between two massive bodies (''gravitational bremsstrahlung''). Our results are valid through post-Newtonian order within general relativity. We discuss in detail the gravitational waveform (transverse-traceless part of the metric perturbation tensor), the toal luminosity and total emitted energy, the angular distribution of emitted energy (antenna pattern), and the frequency spectrum. We also present a method of ''boosting'' the accuracy of these quantities to post-3/2-Newtonian order. A numerical comparison of our results with those of Peters and of Kovacs and Thorne shows that the post-Newtonian method is reliable to better than 0.1% at v=0.1c, to a few percent at v=0.35c, and to 10--20% at v=0.5c. We also compare our results with those of Smarr

  12. Determination of the photoeffect cross section and the K- absorption edge energy of Dy, Ta, Pt and Au atoms using Bremsstrahlung

    International Nuclear Information System (INIS)

    Garcia-Alvarez, J. A.; Lopez-Pino, N.; Diaz Rizo, O.; Corrales, Y.; Padilla-Cabal, F.; Perez-Liva, M.; D' Alessandro, K.; Maidana, N. L.

    2011-01-01

    An experiment to determine the K-shell photoelectric cross-section (CS) of Dy, Ta, Pt and Au atoms was implemented at the Nuclear Analytical Laboratory (LAN) of the InSTEC. Bremsstrahlung photons, produced by 90 Sr- 90 Y beta particles hitting a thin Ni converter, were used to irradiate the foils target of the elements under study. A HPGe detector, coupled to standard nuclear instrumentation, collected the incident and transmitted spectra. A sharp decrease in intensity at the K-shell binding energy was observed in the transmitted spectra. The photon beam divergence effects were corrected with a calibration curve calculated by means of Monte Carlo simulations (MCNPX 2.6). In order to establish accurately the CS at the K-edge energy, the obtained data was processed by two methods: fitting the total CS to a sigmoidal function, as well as the CS branches around the K edge to the empirical law σ=(A/E) n . The results were compared with experimental and theoretical values showing the best agreement when the thinner foils were used. (Author)

  13. Quantum-mechanical suppression of bremsstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Becker-Szendy, R.; Keller, L.; Niemi, G.; Perl, M.; Rochester, L. [Stanford Univ., CA (United States); Anthony, P. [Stanford Univ., CA (United States)]|[Lawrence Livermore National Lab., CA (United States); Bosted, P. [American Univ., Washington, DC (United States); Cavalli-Sforza, M.; Kelley, L.; Klein, S. [Univ. of California, Santa Cruz, CA (United States)] [and others

    1994-12-01

    The authors have studied quantum-mechanical suppression of bremsstrahlung of low-energy 1-500 MeV photons from high-energy 25 GeV electrons. They have measured the LPM effect, where multiple scattering of the radiating electron destroys coherence required for the emission of low-energy photons, and the dielectric effect, where the emitted photon traveling in the radiator medium interferes with itself. For the experiment, the collaboration developed a novel method of extracting a parasitic low-intensity high-energy electron beam into the fixed target area during normal SLC operation of the accelerator. The results agree quantitatively with Migdal`s calculation of the LPM effect. Surface effects, for which there is no satisfactory theoretical prediction, are visible at low photon energies. For very thin targets, the suppression disappears, as expected. Preliminary results on dielectric suppression of bremsstrahlung are in qualitative agreement with the expectation.

  14. The elementary process of Bremsstrahlung

    CERN Document Server

    Haug, Eberhard

    2004-01-01

    This book deals with the theory and experiment of the elementary process of bremsstrahlung, where photons are detected in coincidence with decelerated outgoing electrons. Such experiments allow for a more stringent check of the theoretical work. The main emphasis is laid on electron-atom bremsstrahlung and electron-electron bremsstrahlung, but further bremsstrahlung processes are also dealt with. In the theoretical parts, triply differential cross sections are derived in various approximations, including electron spin and photon-polarization. In the experimental sections, electron-photon coinc

  15. Modeling the bremsstrahlung emission from converters

    CERN Document Server

    Mirea, M; Clapier, F; Hassaïne, M; Ibrahim, F; Müller, A C; Pauwels, N; Proust, J; Verney, D; Antoni, R; Bourgeois, L; Kandri-Rody, S

    2001-01-01

    The bremsstrahlung angular and energy theoretical distributions delivered from W and UCx thick converters are reported. This study is focussed on initial kinetic energies of the electron beam included in the range 30-60 MeV, suitable for the production of large radiative yields able to induce the $^{238}$U fission. These results offer the possibility to evaluate the required shielding for a neutron rich nuclei source.

  16. Comparison of analytical and Monte Carlo calculations of multi-photon effects in bremsstrahlung emission by high-energy electrons

    DEFF Research Database (Denmark)

    Mangiarotti, Alessio; Sona, Pietro; Ballestrero, Sergio

    2012-01-01

    Approximate analytical calculations of multi-photon effects in the spectrum of total radiated energy by high-energy electrons crossing thin targets are compared to the results of Monte Carlo type simulations. The limits of validity of the analytical expressions found in the literature are establi...

  17. Diffractive corrections to the muon Bremsstrahlung

    International Nuclear Information System (INIS)

    Kel'ner, S.R.; Fedotov, A.M.

    1999-01-01

    The corrections to the muon Bremsstrahlung cross section due to diffraction of hard photons on nuclei are obtained. In this process the momentum is transmitted to a nucleus not by a charged particle but by the photon the interaction of which with the nucleus can be considered as diffraction on weakly absorbing ball. The amplitude of the process interferes with the usual Bremsstrahlung amplitude, therefore in the cross section together with the diffraction correction the interference term also appears, possessing different sings for μ + and μ - . The photon emission cross section also depends on the sing of muon charge and for muon energy about 10 TeV the difference between the cross section may reach 10%. The corrections to the radiation energy loss are also calculated [ru

  18. Gluon Bremsstrahlung in Weakly-Coupled Plasmas

    International Nuclear Information System (INIS)

    Arnold, Peter

    2009-01-01

    I report on some theoretical progress concerning the calculation of gluon bremsstrahlung for very high energy particles crossing a weakly-coupled quark-gluon plasma. (i) I advertise that two of the several formalisms used to study this problem, the BDMPS-Zakharov formalism and the AMY formalism (the latter used only for infinite, uniform media), can be made equivalent when appropriately formulated. (ii) A standard technique to simplify calculations is to expand in inverse powers of logarithms ln(E/T). I give an example where such expansions are found to work well for ω/T≥10 where ω is the bremsstrahlung gluon energy. (iii) Finally, I report on perturbative calculations of q.

  19. Uncertainty and sensitivity analysis of the effect of the mean energy and FWHM of the initial electron fluence on the Bremsstrahlung photon spectra of linear accelerators

    International Nuclear Information System (INIS)

    Juste, B.; Miró, R.; Verdú, G.; Macián, R.

    2012-01-01

    A calculation of the correct dose in radiation therapy requires an accurate description of the radiation source because uncertainties in characterization of the linac photon spectrum are propagated through the dose calculations. Unfortunately, detailed knowledge of the initial electron beam parameters is not readily available, and many researchers adjust the initial electron fluence values by trial-and-error methods. The main goal of this work was to develop a methodology to characterize the fluence of initial electrons before they hit the tungsten target of an Elekta Precise medical linear accelerator. To this end, we used a Monte Carlo technique to analyze the influence of the characteristics of the initial electron beam on the distribution of absorbed dose from a 6 MV linac photon beam in a water phantom. The technique is based on calculations with Software for Uncertainty and Sensitivity Analysis (SUSA) and Monte Carlo simulations with the MCNP5 transport code. The free parameters used in the SUSA calculations were the mean energy and full-width-at-half-maximum (FWHM) of the initial electron distribution. A total of 93 combinations of these parameters gave initial electron fluence configurations. The electron spectra thus obtained were used in a simulation of the electron transport through the target of the linear accelerator, which produced different photon (Bremsstrahlung) spectra. The simulated photon spectra were compared with the 6-MV photon spectrum provided by the linac manufacturer (Elekta). This comparison revealed how the mean energy and FWHM of the initial electron fluence affect the spectrum of the generated photons. This study has made it possible to fine-tune the examined electron beam parameters to obtain the resulted absorbed doses with acceptable accuracy (error <1%). - Highlights: ► Mean energy and radial spread are important parameters for simulating the incident electron beam in radiation therapy. ► Errors in determining the electron

  20. Bremsstrahlung-induced highly penetrating probes for nondestructive assay and defect analysis

    CERN Document Server

    Selim, F A; Harmon, J F; Kwofie, J; Spaulding, R; Erickson, G; Roney, T

    2002-01-01

    Nondestructive assay and defect analysis probes based on bremsstrahlung-induced processes have been developed to identify elements and probe defects in large volume samples. Bremsstrahlung beams from (electron accelerators) with end-point energies both above and below neutron emission threshold have been used. Below neutron emission threshold these beams (from 6 MeV small pulsed linacs), which exhibit high penetration, create positrons via pair production inside the material and produce X-ray fluorescence (XRF) radiation. Chemical assays of heavy elements in thick samples up to 10 g/cm sup 2 thick are provided by energy dispersive XRF measurements. The pair-produced positrons annihilate within the material, thereby emitting 511 keV gamma radiation. Doppler broadening spectroscopy of the 511 keV radiation can be performed to characterize the material and measure defects in samples of any desired thickness. This technique has successfully measured induced strain due to tensile stress in steel samples of 0.64 cm...

  1. The (γ, p) reaction in 30Si, 68Zn and 130Te at intermediate energies

    International Nuclear Information System (INIS)

    Bulow, B.; Johnsson, B.; Nilsson, M.

    1977-01-01

    The yields of (γ, p) reactions on 30 Si, 68 Zn and 130 Te have been measured as a function of the bremsstrahlung end-point energy, Esub(γ, max), in the energy range 75-800 MeV, using the activation method. Cross sections have been deduced and are compared to results obtained using a semiempirical model. (Auth.)

  2. Shielding calculation for bremsstrahlung from β-emitters

    International Nuclear Information System (INIS)

    Ichimiya, Tsutomu

    1990-01-01

    Accompanying the revision of radiation injury prevention law, the shielding calculation method for photon corresponding to the dose equivalent was shown. However, regarding the electron from β decay nuclide and bremsstrahlung caused by shielding material, the shielding calculation method corresponding to the 1 cm dose equivalent has not been reported, hence, in this report, the spectrum of β-ray is calculated and the 1 cm dose equivalent transmission rate of the bremsstrahlung was calculated for three kinds of shielding materials (iron, lead, concrete). As the result of consideration, it is sufficient to think about the bremsstrahlung due to negative electron emission accompanying β-decay. In β-decay, electrons which constitute the continuous spectrum with maximum energy are emitted. The shape of the spectrum differs with nuclides. The maximum energy of β-ray of generally used nuclides is mostly below 3MeV and, besides, the electron ray itself is easily shielded, while the strength of bremsstrahlung depends on the atomic number of shielding materials and its generating mechanism is complicated. In this report, the actual shielding calculation method for bremsstrahlung is shown with regard to the most frequently used β-decay nuclides. (M.T.)

  3. Electron collision effects on the bremsstrahlung emission in Lorentzian plasmas

    International Nuclear Information System (INIS)

    Jung, Young-Dae; Kato, Daiji

    2009-06-01

    The electron-electron collision effects on the electron-ion bemsstranhlung process are investigated in warm Lorentzian plasmas. The effective electron-ion interaction potential is obtained by including the far-field terms caused by the electron-electron collisions with the effective Debye length in Lorentzian plasmas. The bremsstranhlung radiation cross section is obtained as a function of the electron energy, photon energy, collision frequency, spectral index, and Debye length using the Born approximation for the initial and final states of the projectile electron. It is shown that the non-Maxwellian character suppresses the bremsstrahlung radiation cross section. It is also shown that the electron-electron collision effect enhances the bremsstrahlung emission spectrum. In addition, the bremsstrahlung radiation cross section decreases with an increase of the plasma temperature. (author)

  4. Electron-electron collision effects on the bremsstrahlung emission in Lorentzian plasmas

    International Nuclear Information System (INIS)

    Jung, Young-Dae; Kato, Daiji

    2009-01-01

    Electron-electron collision effects on the electron-ion bremsstrahlung process are investigated in Lorentzian plasmas. The effective electron-ion interaction potential is obtained by including the far-field terms caused by electron-electron collisions with an effective Debye length in Lorentzian plasmas. The bremsstrahlung radiation cross section is obtained as a function of the electron energy, photon energy, collision frequency, spectral index and Debye length using the Born approximation for the initial and final states of the projectile electron. It is shown that the non-Maxwellian character suppresses the bremsstrahlung radiation cross section. It is also shown that the electron-electron collision effect enhances the bremsstrahlung emission spectrum. In addition, the bremsstrahlung radiation cross section decreases with an increase in the plasma temperature.

  5. Bremsstrahlung emission probability in the α decay of 210Po

    International Nuclear Information System (INIS)

    Boie, Hans-Hermann

    2009-01-01

    A high-statistics measurement of bremsstrahlung emitted in the α decay of 210 Po has been performed. The measured differential emission probabilities, which could be followed up to γ-energies of ∝ 500 keV, allow for the first time for a serious test of various model calculations of the bremsstrahlung accompanied α decay. It is shown that corrections to the α-γ angular correlation due to the interference between the electric dipole and quadrupole amplitudes and due to the relativistic character of the process have to be taken into account. With the experimentally derived angular correlation the measured energydifferential bremsstrahlung emission probabilities show excellent agreement with the fully quantum mechanical calculation. (orig.)

  6. The Stonehenge technique. A method for aligning coherent bremsstrahlung radiators

    International Nuclear Information System (INIS)

    Livingston, Ken

    2009-01-01

    This paper describes a technique for the alignment of crystal radiators used to produce high energy, linearly polarized photons via coherent bremsstrahlung scattering at electron beam facilities. In these experiments the crystal is mounted on a goniometer which is used to adjust its orientation relative to the electron beam. The angles and equations which relate the crystal lattice, goniometer and electron beam direction are presented here, and the method of alignment is illustrated with data taken at MAMI (the Mainz microtron). A practical guide to setting up a coherent bremsstrahlung facility and installing new crystals using this technique is also included.

  7. The Stonehenge technique. A method for aligning coherent bremsstrahlung radiators

    Energy Technology Data Exchange (ETDEWEB)

    Livingston, Ken [Department of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom)], E-mail: k.livingston@physics.gla.ac.uk

    2009-05-21

    This paper describes a technique for the alignment of crystal radiators used to produce high energy, linearly polarized photons via coherent bremsstrahlung scattering at electron beam facilities. In these experiments the crystal is mounted on a goniometer which is used to adjust its orientation relative to the electron beam. The angles and equations which relate the crystal lattice, goniometer and electron beam direction are presented here, and the method of alignment is illustrated with data taken at MAMI (the Mainz microtron). A practical guide to setting up a coherent bremsstrahlung facility and installing new crystals using this technique is also included.

  8. The Stonehenge technique. A method for aligning coherent bremsstrahlung radiators

    Science.gov (United States)

    Livingston, Ken

    2009-05-01

    This paper describes a technique for the alignment of crystal radiators used to produce high energy, linearly polarized photons via coherent bremsstrahlung scattering at electron beam facilities. In these experiments the crystal is mounted on a goniometer which is used to adjust its orientation relative to the electron beam. The angles and equations which relate the crystal lattice, goniometer and electron beam direction are presented here, and the method of alignment is illustrated with data taken at MAMI (the Mainz microtron). A practical guide to setting up a coherent bremsstrahlung facility and installing new crystals using this technique is also included.

  9. Proton-proton bremsstrahlung towards the elastic limit

    Science.gov (United States)

    Mahjour-Shafiei, M.; Amir-Ahmadi, H. R.; Bacelar, J. C. S.; Castelijns, R.; Ermisch, K.; van Garderen, E.; Gašparić, I.; Harakeh, M. N.; Kalantar-Nayestanaki, N.; Kiš, M.; Löhner, H.

    2005-05-01

    In oder to study proton-proton bremsstrahlung moving towards the elastic limit, a detection system, consisting of Plastic-ball and SALAD, was set up and an experiment at 190 MeV incident beam energy was performed. Here, the experimental setup and the data analysis procedure along with some results obtained in the measurement are discussed.

  10. Proton-proton bremsstrahlung towards the elastic limit

    International Nuclear Information System (INIS)

    Mahjour-Shafiei, M.; Amir-Ahmadi, H.R.; Bacelar, J.C.S.; Castelijns, R.; Ermisch, K.; Garderen, E. van; Harakeh, M.N.; Kalantar-Nayestanaki, N.; Kis, M.; Loehner, H.; Gasparic, I.

    2005-01-01

    In oder to study proton-proton bremsstrahlung moving towards the elastic limit, a detection system, consisting of Plastic-ball and SALAD, was set up and an experiment at 190 MeV incident beam energy was performed. Here, the experimental setup and the data analysis procedure along with some results obtained in the measurement are discussed

  11. Coulomb correction calculations of pp Bremsstrahlung

    International Nuclear Information System (INIS)

    Katsogiannis, A.; Amos, K.; Jetter, M.; von Geramb, H.V.

    1994-01-01

    The effects of the Coulomb interaction upon the photon cross section and analyzing power from pp Bremsstrahlung have been studied in detail. Off-shell properties of the Coulomb T matrices have been considered but the associated, Coulomb modified, hadronic T matrices are important elements in any analyses of low energy, forward proton scattering data. At the lowest energy considered (5 MeV), the full calculations gave cross sections that were half the size of those found without Coulomb effects or with a simple model approximation to them. With increasing energy, the cross sections varied to those characteristic of magnetic interaction dominance and the specific differences due to Coulomb effects diminished. 47 refs., 7 figs

  12. Gluon bremsstrahlung and elastic scattering of hadrons

    International Nuclear Information System (INIS)

    Povh, B.

    2001-01-01

    The differential and the total cross sections in high energy hadron-proton interactions give a beautiful insight in the low Q 2 structure of the nucleon. The cross section is composed of two parts: a large energy independent part corresponding to the interaction of the valence quark with the target without gluon radiation and an energy dependent part caused by gluon bremsstrahlung. The gluons are located at small transverse distances of about 0.3 fm from the valence quarks. The model with two scales, the size of the hadron (R 2 ∼ 1 fm 2 ) and the size of the gluonic cloud (r 0 2 ∼ 0.1 fm 2 ), correctly predicts the total and the differential cross sections and the behaviour of diffractive dissociation in hadronic and deep inelastic events. (orig.)

  13. Bremsstrahlung converter debris shields: test and analysis

    International Nuclear Information System (INIS)

    Reedy, E.D. Jr.; Perry, F.C.

    1983-10-01

    Electron beam accelerators are commonly used to create bremsstrahlung x-rays for effects testing. Typically, the incident electron beam strikes a sandwich of three materials: (1) a conversion foil, (2) an electron scavenger, and (3) a debris shield. Several laboratories, including Sandia National Laboratories, are developing bremsstrahlung x-ray sources with much larger test areas (approx. 200 to 500 cm 2 ) than ever used before. Accordingly, the debris shield will be much larger than before and subject to loads which could cause shield failure. To prepare for this eventuality, a series of tests were run on the Naval Surface Weapons Center's Casino electron beam accelerator (approx. 1 MeV electrons, 100 ns FWHM pulse, 45 kJ beam energy). The primary goal of these tests was to measure the stress pulse which loads a debris shield. These measurements were made with carbon gages mounted on the back of the converter sandwich. At an electron beam fluence of about 1 kJ/cm 2 , the measured peak compressive stress was typically in the 1 to 2 kbar range. Measured peak compressive stress scaled in a roughly linear manner with fluence level as the fluence level was increased to 10 kJ/cm 2 . The duration of the compressive pulse was on the order of microseconds. In addition to the stress wave measurements, a limited number of tests were made to investigate the type of damage generated in several potential shield materials

  14. Simulation of the Focal Spot of the Accelerator Bremsstrahlung Radiation

    Science.gov (United States)

    Sorokin, V.; Bespalov, V.

    2016-06-01

    Testing of thick-walled objects by bremsstrahlung radiation (BR) is primarily performed via high-energy quanta. The testing parameters are specified by the focal spot size of the high-energy bremsstrahlung radiation. In determining the focal spot size, the high- energy BR portion cannot be experimentally separated from the low-energy BR to use high- energy quanta only. The patterns of BR focal spot formation have been investigated via statistical modeling of the radiation transfer in the target material. The distributions of BR quanta emitted by the target for different energies and emission angles under normal distribution of the accelerated electrons bombarding the target have been obtained, and the ratio of the distribution parameters has been determined.

  15. Zeff measurements in ATF using visible bremsstrahlung

    International Nuclear Information System (INIS)

    Morita, S.; Richards, R.K.; Horton, L.D.; Isler, R.C.; Crume, E.C. Jr.; Murakami, M.

    1991-04-01

    Measurements of the effective charge Z eff in plasmas with electron cyclotron heating (ECH) and neutral beam injection (NBI) in the Advanced Toroidal Facility (ATF) have been carried out using visible bremsstrahlung. The electron temperature needed for the analysis is calculated from the measured stored energy and electron density. The value of Z eff varies widely depending on experimental conditions. In ECH plasmas it is between 2 and 8. In NBI plasmas, which are subject to radiation collapse, Z eff is between 3 and 5 at the time the stored energy reaches a maximum. However, Z eff is less than 2.5 in quasi-steady medium-density plasmas and is close to 1.2 in the highest-density plasmas, where the average electron density bar n e is of the order of 10 14 cm -3 . 12 refs., 29 figs., 1 tab

  16. Electron bremsstrahlung spectrum, 1--500 keV

    International Nuclear Information System (INIS)

    Lee, C.M.; Kissel, L.; Pratt, R.H.; Tseng, H.K.

    1976-01-01

    Numerical data are obtained for the electron bremsstrahlung energy spectrum resulting from incident electrons of kinetic energy 1--500 keV, under the assumption that the process is described as a single-electron transition in a relativistic self-consistent screened potential, using partial-wave expansions. Comparisons with simpler analytical approximations show that these are at best of qualitative validity in this energy range. Our data are used to construct more complete tables of the spectrum by interpolation

  17. Bremsstrahlung in atom-atom collisions

    International Nuclear Information System (INIS)

    Amus'ya, M.Y.; Kuchiev, M.Y.; Solov'ev, A.V.

    1985-01-01

    It is shown that in the collision of a fast atom with a target atom when the frequencies are on the order of the potentials or higher, there arises bremsstrahlung comparable in intensity with the bremsstrahlung emitted by an electron with the same velocity in the field of the target atom. The mechanism by which bremsstrahlung is produced in atom-atom collisions is elucidated. Results of specific calculations of the bremsstrahlung spectra are given for α particles and helium atoms colliding with xenon

  18. Dose Measurements of Bremsstrahlung-Produced Neutrons at the Advanced Photon Source

    International Nuclear Information System (INIS)

    Job, P.K.; Pisharody, M.; Semones, E.

    1998-01-01

    Bremsstrahlung is generated in the storage rings of the synchrotron radiation facilities by the radiative interaction of the circulating particle beam with both the residual gas molecules and storage ring components. These bremsstrahlung photons, having an energy range of zero to the maximum energy of the particle beam, interact with beamline components like beam stops and collimators generating photoneutrons of varying energies. There are three main processes by which photoneutrons may be produced by the high energy bremsstrahlung photons: giant nuclear dipole resonance and decay (10 MeV γ γ γ > 140 MeV). The giant resonance neutrons are emitted almost isotropically and have an average energy of about 2 MeV. High energy neutrons (E > 10 MeV) emitted from the quasi-deuteron decay and intranuclear cascade are peaked in the forward direction. At the Advanced Photon Source (APS), where bremsstrahlung energy can be as high as 7 GeV, production of photoneutrons in varying yields is possible from all of the above three processes. The bremsstrahlung produced along a typical 15.38-m straight path of the insertion device (ID) beamline of the APS has been measured and analyzed in previous studies. High-Z materials constituting the beamline components, such as collimators and beam stops, can produce photoneutrons upon interaction with these bremsstrahlung photons. The 1/E nature of the bremsstrahlung spectrum and the fact that the photoneutron production cross section is comparatively larger in the energy region 10 MeV γ 3 detector, as well as a very sensitive pressurized 3 He detector, is used for neutron dose measurements. The dose equivalent rates, normalized to bremsstrahlung power, beam current, and storage ring vacuum, are measured for various targets. This report details the experimental setup,

  19. Assembler absolute forward thick-target bremsstrahlung spectra program

    International Nuclear Information System (INIS)

    Niculescu, V.I.R.; Baciu, G.; Ionescu-Bujor, M.

    1981-12-01

    The program is intended to compute the absolute forward thick-target bremsstrahlung spectrum for electrons in the energy range 1-24 MeV. The program takes into account the following phenomena: multiple scattering, energy loss and the attenuation of the emitted gamma rays. The computer program is written in Assembler having a higher degree of generality and is more performant than the FORTRAN version. (authors)

  20. Polarizational bremsstrahlung in non-relativistic collisions

    International Nuclear Information System (INIS)

    Korol, A.V.; Solov'yov, A.V.

    2006-01-01

    We review the developments made during the last decade in the theory of polarization bremsstrahlung in the non-relativistic domain. A literature survey covering the latest history of the phenomenon is given. The main features which distinguish the polarization bremsstrahlung from other mechanisms of radiation are discussed and illustrated by the results of numerical calculations

  1. Density oscillations of nuclear matter probed via Bremsstrahlung photons

    International Nuclear Information System (INIS)

    Marques, F.M.; Ostendorf, R.W.

    1996-01-01

    From the extended experimental data on hard-photon production at intermediate energies the dominant source of hard-photons has been attributed to the Bremsstrahlung radiation emitted in first-chance proton-neutron (pn) collisions. Aside of the dominant source which produces direct hard-photons, at intermediate energies BUU calculations predict the existence of a second source of pn Bremsstrahlung photons occurring at a later stage of the heavy-ion collision when the system is almost fully thermalized, thermal hard-photons. The existence of this second photon source is searched for by analysing the energy spectra of inclusive and exclusive hard-photons and the photon-photon correlation function for three different systems. (K.A.)

  2. Bremsstrahlung X rays from Jovian auroral electrons

    International Nuclear Information System (INIS)

    Barbosa, D.D.

    1990-01-01

    The spectrum of X rays from the planet Jupiter is calculated according to an auroral electron beam model. The electrons are assumed to be accelerated by a field-aligned potential drop and penetrate into the atmosphere as a Maxwellian beam of primaries which are scattered, degraded in energy, and merged with a population of ionization secondaries having a power law energy distribution. The soft X rays observed by the Einstein Observatory satelltie are due to bremsstrahlung from the sedondary electrons in the H 2 atmosphere. A good match to the X ray data is obtained if the power law spectral index of the secondary electrons, γ e , is ≅ 2, yielding a power law slope for the photon flux γ X = γ e + 1 ≅ 3. The X ray intensity is best reconciled with a beam of primaries having a characteristic energy 30-100 keV and penetrating the homopause with an auroral energy flux typically of 10-20 ergs cm -2 s -1 but no greater than 50 ergs cm -2 s -1

  3. Diffractive bremsstrahlung at high-β{sup *} LHC. Case study

    Energy Technology Data Exchange (ETDEWEB)

    Chwastowski, Janusz J.; Czekierda, Sabina; Staszewski, Rafal; Trzebinski, Maciej [The Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences, Krakow (Poland)

    2017-04-15

    Feasibility studies of the measurement of the exclusive diffractive bremsstrahlung cross-section in proton-proton scattering at the centre of mass energy of 13 TeV at the LHC are reported. Present studies were performed for the low luminosity LHC running with the betatron function value of 90 m using the ATLAS associated forward detectors ALFA and ZDC. A simplified approach to the event simulation and reconstruction is used. The background influence is also discussed. (orig.)

  4. Beta Bremsstrahlung dose in concrete shielding

    Energy Technology Data Exchange (ETDEWEB)

    Manjunatha, H.C., E-mail: manjunatha@rediffmail.com [Department of Physics, Government college for women, Kolar 563101, Karnataka (India); Chandrika, B.M. [Shravana, 592, Ist Cross, Behind St.Anne s School, PC Extension, Kolar 563101, Karnataka (India); Rudraswamy, B. [Department of Physics, Bangalore University, Bangalore 560056, Karnataka (India); Sankarshan, B.M. [Shravana, 592, Ist Cross, Behind St.Anne s School, PC Extension, Kolar 563101, Karnataka (India)

    2012-05-11

    In a nuclear reactor, beta nuclides are released during nuclear reactions. These betas interact with shielding concrete and produces external Bremsstrahlung (EB) radiation. To estimate Bremsstrahlung dose and shield efficiency in concrete, it is essential to know Bremsstrahlung distribution or spectra. The present work formulated a new method to evaluate the EB spectrum and hence Bremsstrahlung dose of beta nuclides ({sup 32}P, {sup 89}Sr, {sup 90}Sr-{sup 90}Y, {sup 90}Y, {sup 91}Y, {sup 208}Tl, {sup 210}Bi, {sup 234}Pa and {sup 40}K) in concrete. The Bremsstrahlung yield of these beta nuclides in concrete is also estimated. The Bremsstrahlung yield in concrete due to {sup 90}Sr-{sup 90}Y is higher than those of other given nuclides. This estimated spectrum is accurate because it is based on more accurate modified atomic number (Z{sub mod}) and Seltzer's data, where an electron-electron interaction is also included. Presented data in concrete provide a quick and convenient reference for radiation protection. The present methodology can be used to calculate the Bremsstrahlung dose in nuclear shielding materials. It can be quickly employed to give a first pass dose estimate prior to a more detailed experimental study. - Highlights: Black-Right-Pointing-Pointer Betas released in a nuclear reactor interact with shielding concrete and produces Bremsstrahlung. Black-Right-Pointing-Pointer The present work formulated a new method to evaluate the Bremsstrahlung spectrum and dose in concrete. Black-Right-Pointing-Pointer Presented data in concrete provide a quick and convenient reference for radiation protection.

  5. Molecular recognition in a diverse set of protein-ligand interactions studied with molecular dynamics simulations and end-point free energy calculations.

    Science.gov (United States)

    Wang, Bo; Li, Liwei; Hurley, Thomas D; Meroueh, Samy O

    2013-10-28

    End-point free energy calculations using MM-GBSA and MM-PBSA provide a detailed understanding of molecular recognition in protein-ligand interactions. The binding free energy can be used to rank-order protein-ligand structures in virtual screening for compound or target identification. Here, we carry out free energy calculations for a diverse set of 11 proteins bound to 14 small molecules using extensive explicit-solvent MD simulations. The structure of these complexes was previously solved by crystallography and their binding studied with isothermal titration calorimetry (ITC) data enabling direct comparison to the MM-GBSA and MM-PBSA calculations. Four MM-GBSA and three MM-PBSA calculations reproduced the ITC free energy within 1 kcal·mol(-1) highlighting the challenges in reproducing the absolute free energy from end-point free energy calculations. MM-GBSA exhibited better rank-ordering with a Spearman ρ of 0.68 compared to 0.40 for MM-PBSA with dielectric constant (ε = 1). An increase in ε resulted in significantly better rank-ordering for MM-PBSA (ρ = 0.91 for ε = 10), but larger ε significantly reduced the contributions of electrostatics, suggesting that the improvement is due to the nonpolar and entropy components, rather than a better representation of the electrostatics. The SVRKB scoring function applied to MD snapshots resulted in excellent rank-ordering (ρ = 0.81). Calculations of the configurational entropy using normal-mode analysis led to free energies that correlated significantly better to the ITC free energy than the MD-based quasi-harmonic approach, but the computed entropies showed no correlation with the ITC entropy. When the adaptation energy is taken into consideration by running separate simulations for complex, apo, and ligand (MM-PBSAADAPT), there is less agreement with the ITC data for the individual free energies, but remarkably good rank-ordering is observed (ρ = 0.89). Interestingly, filtering MD snapshots by prescoring

  6. Analytic approximate radiation effects due to Bremsstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Ben-Zvi I.

    2012-02-01

    The purpose of this note is to provide analytic approximate expressions that can provide quick estimates of the various effects of the Bremsstrahlung radiation produced relatively low energy electrons, such as the dumping of the beam into the beam stop at the ERL or field emission in superconducting cavities. The purpose of this work is not to replace a dependable calculation or, better yet, a measurement under real conditions, but to provide a quick but approximate estimate for guidance purposes only. These effects include dose to personnel, ozone generation in the air volume exposed to the radiation, hydrogen generation in the beam dump water cooling system and radiation damage to near-by magnets. These expressions can be used for other purposes, but one should note that the electron beam energy range is limited. In these calculations the good range is from about 0.5 MeV to 10 MeV. To help in the application of this note, calculations are presented as a worked out example for the beam dump of the R&D Energy Recovery Linac.

  7. Analytic approximate radiation effects due to Bremsstrahlung

    International Nuclear Information System (INIS)

    Ben-Zvi, I.

    2012-01-01

    The purpose of this note is to provide analytic approximate expressions that can provide quick estimates of the various effects of the Bremsstrahlung radiation produced relatively low energy electrons, such as the dumping of the beam into the beam stop at the ERL or field emission in superconducting cavities. The purpose of this work is not to replace a dependable calculation or, better yet, a measurement under real conditions, but to provide a quick but approximate estimate for guidance purposes only. These effects include dose to personnel, ozone generation in the air volume exposed to the radiation, hydrogen generation in the beam dump water cooling system and radiation damage to near-by magnets. These expressions can be used for other purposes, but one should note that the electron beam energy range is limited. In these calculations the good range is from about 0.5 MeV to 10 MeV. To help in the application of this note, calculations are presented as a worked out example for the beam dump of the R and D Energy Recovery Linac.

  8. Gravitational bremsstrahlung in ultra-planckian collisions

    CERN Document Server

    Gal'tsov, Dmitry; Tomaras, Theodore N

    2013-01-01

    A classical computation of gravitational bremsstrahlung in ultra-planckian collisions of massive point particles is presented in an arbitrary number d of toroidal or non-compact extra dimensions. Our method generalizes the post-linear formalism of General Relativity to the multidimensional case. The total emitted energy, as well as its angular and frequency distribution are discussed in detail. In terms of the gravitational radius r_S of the collision energy, the impact parameter b and the Lorentz factor in the CM frame, the leading order radiation efficiency in the Lab frame is shown to be of order (r_S/b)^{3(d+1)} gamma_{cm} for d=0, 1 and of order (r_S/b)^{3(d+1)} gamma_{cm}^{2d-3} for d>1, up to a known d-dependent coefficient and a ln gamma_{cm} factor for d=2, while the characteristic frequency of the radiation is gamma/b. The contribution of the low frequency part of the radiation (soft gravitons) to the total radiated energy is shown to be negligible for all values of d. The domain of validity of the ...

  9. Precision gamma-ray polarimetry applied to studies of bremsstrahlung produced by polarized electrons

    Energy Technology Data Exchange (ETDEWEB)

    Kovtun, Oleksiy

    2015-12-16

    The thesis reports on the measurement of bremsstrahlung linear polarization produced in collisions of longitudinally and transversely polarized electrons with gold atoms. The experiment was performed at the Mainzer Microtron MAMI in the Institut fuer Kernphysik of Johannes Gutenberg-Universitaet Mainz, Germany. Spin-oriented electrons with 2.15 MeV kinetic energy collided with a thin golden target and produced bremsstrahlung. Linear polarization of the emitted photons was measured by means of Compton polarimetry applied to a segmented high-purity germanium detector. Experimental results reveal a strong correlation between the electron spin orientation and bremsstrahlung linear polarization. This indicates a dominant role of the electron spin in atomic-field bremsstrahlung and Coulomb scattering.

  10. Polarization of Bremsstrahlung; Polarisation du rayonnement de freinage

    Energy Technology Data Exchange (ETDEWEB)

    Miller, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1957-07-01

    The numerical results for the polarization of Bremsstrahlung are presented. The multiple scattering of electrons in the target is taken into account. The angular-and photon energy dependences are seen on the curves for an incident 25 MeV electron energy. (Author) [French] Le taux de polarisation d'un spectre de rayonnement de freinage est calcule pour une cible d'epaisseur finie en tenant compte de la diffusion multiple des electrons dans la cible. Les courbes sont tracees pour les electrons incidents d'energie 25 MeV, pour differentes energies de photons, et a differents angles. (auteur)

  11. The LPM effect in sequential bremsstrahlung: 4-gluon vertices

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, Peter; Chang, Han-Chih [Department of Physics, University of Virginia,382 McCormick Road, Charlottesville, Virginia 22904-4714 (United States); Iqbal, Shahin [National Centre for Physics, Quaid-i-Azam University Campus, Islamabad, 45320 (Pakistan)

    2016-10-24

    The splitting processes of bremsstrahlung and pair production in a medium are coherent over large distances in the very high energy limit, which leads to a suppression known as the Landau-Pomeranchuk-Migdal (LPM) effect. In this paper, we continue study of the case when the coherence lengths of two consecutive splitting processes overlap (which is important for understanding corrections to standard treatments of the LPM effect in QCD), avoiding soft-gluon approximations. In particular, this paper completes the calculation of the rate for real double gluon bremsstrahlung from an initial gluon with various simplifying assumptions (thick media; q̂ approximation; and large N{sub c}) by now including processes involving 4-gluon vertices.

  12. Bremsstrahlung convertors: materials design and development

    International Nuclear Information System (INIS)

    Allred, R.E.

    1976-03-01

    An improved bremsstrahlung convertor for use at high electron beam energies was developed. The convertor consists of three main components: (1) conversion foil; (2) electron scavenger; and (3) impulse shield. Structural failures of the impulse shield were experimentally determined to be caused by shock wave interactions. Convertor materials and design modifications were aimed at attenuation of the magnitude of the shock and maximization of energy absorption by the convertor materials. Techniques proven successful included the introduction of porosity into electron scavenger and impulse shield materials, the use of a standoff between the conversion foil and the electron scavenger, the insertion of a gap between the scavenger and impulse shield, and the use of advanced composite materials for the impulse shield. These modifications have increased the convertor operating range from 4 cal/gm Au to over 8 cal/gm Au. Kevlar 49 reinforced-resin composites have proven to have the best combination of strength, stiffness, toughness, and x-ray transport properties for use as bremmstrahlung convertor impulse shields

  13. Planar gamma camera imaging and quantitation of Yttrium-90 bremsstrahlung

    International Nuclear Information System (INIS)

    Shen, S.; DeNardo, G.L.; Yuan, A.

    1994-01-01

    Yttrium-90 is a promising radionuclide for radioimmunotherapy of cancer because of its energetic beta emissions. Therapeutic management requires quantitative imaging to assess the pharmacokinetics and radiation dosimetry of the 90 Y-labeled antibody. Conventional gamma photon imaging methods cannot be easily applied to imaging of 90 Y-bremsstrahlung because of its continuous energy spectrum. The sensitivity, resolution and source-to-background signal ratio (S/B) of the detector system for 90 Y-bremsstrahlung were investigated for various collimators and energy windows in order to determine optimum conditions for quantitative imaging. After these conditions were determined, the accuracy of quantitation of 90 Y activity in an Alderson abdominal phantom was examined. When the energy-window width was increased, the benefit of increased sensitivity outweighed degradation in resolution and S/B ratio until the manufacturer's energy specifications for the collimator were exceeded. Using the same energy window, the authors improved resolution and S/B for the medium-energy (ME) collimator when compared to the low-energy, all-purpose (LEAP) collimator, and there was little additional improvement using the high-energy (HE) collimator. Camera sensitivity under tissue equivalent conditions was 4.2 times greater for the LEAP and 1.7 times greater for the ME collimators when compared to the HE collimator. Thus, the best, most practical selections were found to be the ME collimator and an energy window of 55-285 keV. When they used these optimal conditions for image acquisition, the estimation of 90 Y activity in organs and tumors was within 15% of the true activities. The results for this study suggest that reasonable accuracy can be achieved in clinical radioimmunotherapy using 90 Y-bremsstrahlung quantitation. 28 refs., 5 figs., 7 tabs

  14. Electron-electron Bremsstrahlung for bound target electrons

    International Nuclear Information System (INIS)

    Haug, E.

    2008-01-01

    For the process of electron-electron (e-e) Bremsstrahlung the momentum and energy distributions of the recoiling electrons are calculated in the laboratory frame. In order to get the differential cross section and the photon spectrum for target electrons which are bound to an atom, these formulae are multiplied by the incoherent scattering function and numerically integrated over the recoil energy. The effect of atomic binding is most pronounced at low energies of the incident electrons and for target atoms of high atomic numbers. The results are compared to those of previous calculations. (authors)

  15. Scintillating fiber array for tagging post-bremsstrahlung electrons

    Science.gov (United States)

    Cole, Philip; Alef, Stefan; Reitz, Björn-Eric; Schmieden, Hartmut; Hannappel, Jürgen; Jude, Thomas; Sandri, Paolo Levi; BGO-OD Collaboration

    2016-03-01

    We seek to extract the kinematic fingerprints of baryon resonances by making use of a high-quality beam of linearly polarized photons at the BGO-OD experiment at ELSA (Bonn, German). We constructed a unique device for precisely determining the degree of polarization in the coherent bremsstrahlung peak. Deflection of post-bremsstrahlung electrons in the magnetic field of the photon tagger provides precise information on the energy and polarization of the bremsstrahlung photons. And thereby will constrain the overall kinematics of the final-state particles in all decay channels of the photoproduced baryon resonances. We designed, prototyped, built, calibrated, and have been operating a three-layered, multi-stranded, scintillating-fiber detector for ensuring the quality of the linearly polarization of the photon beam. The overlapping 2.00-mm scintillating fibers form an array giving ARGUS over 500 channels. The very befitting name harkens to the mythological all-seeing creature Argus Panoptes, the multi-eyed giant. Our work was supported through a Fulbright Scholarship Award and by the Deutsche Forschungsgemeinschaft through the Collaborative Research Center (Sonderforschungsbereich SFB/TR-16) of the universities in Bonn, Giessen and Bochum, Germany. NSF-PHY-1307340.

  16. Monte Carlo computation of Bremsstrahlung intensity and energy spectrum from a 15 MV linear electron accelerator tungsten target to optimise LINAC head shielding

    International Nuclear Information System (INIS)

    Biju, K.; Sharma, Amiya; Yadav, R.K.; Kannan, R.; Bhatt, B.C.

    2003-01-01

    The knowledge of exact photon intensity and energy distributions from the target of an electron target is necessary while designing the shielding for the accelerator head from radiation safety point of view. The computations were carried out for the intensity and energy distribution of photon spectrum from a 0.4 cm thick tungsten target in different angular directions for 15 MeV electrons using a validated Monte Carlo code MCNP4A. Similar results were computed for 30 MeV electrons and found agreeing with the data available in literature. These graphs and the TVT values in lead help to suggest an optimum shielding thickness for 15 MV Linac head. (author)

  17. Simulation of electron, positron and Bremsstrahlung spectrum generated due to electromagnetic cascade by 2.5 GeV electron hitting lead target using FLUKA code

    International Nuclear Information System (INIS)

    Sahani, P.K.; Dev, Vipin; Haridas, G.; Thakkar, K.K.; Singh, Gurnam; Sarkar, P.K.; Sharma, D.N.

    2009-01-01

    INDUS-2 is a high energy electron accelerator facility where electrons are accelerated in circular ring up to maximum energy 2.5 GeV, to generate synchrotron radiation. During normal operation of the machine a fraction of these electrons is lost, which interact with the accelerator structures and components like vacuum chamber and residual gases in the cavity and hence generates significant amount of Bremsstrahlung radiation. The Bremsstrahlung radiation is highly dependent on the incident electron energy, target material and its thickness. The Bremsstrahlung radiation dominates the radiation environment in such electron storage rings. Because of its broad spectrum extending up to incident electron energy and pulsed nature, it is very difficult to segregate the Bremsstrahlung component from the mixed field environment in accelerators. With the help of FLUKA Monte Carlo code, Bremsstrahlung spectrum generated from 2.5 GeV electron on bombardment of high Z lead target is simulated. To study the variation in Bremsstrahlung spectrum on target thickness, lead targets of 3, 6, 9, 12, 15, 18 mm thickness was used. The energy spectrum of emerging electron and positron is also simulated. The study suggests that as the target thickness increases, the emergent Bremsstrahlung photon fluence increases. With increase in the target thickness Bremsstrahlung photons in the spectrum dominate the low energy part and degrade in high energy part. The electron and positron spectra also extend up to incident electron energy. (author)

  18. Bremsstrahlung from relativistic bare heavy ions: Nuclear and electronic contributions in amorphous and crystalline materials

    DEFF Research Database (Denmark)

    Jensen, Tue Vissing; Sørensen, Allan Hvidkjær

    2013-01-01

    A charged particle emits bremsstrahlung while traversing matter. We calculate the radiation cross section for bare heavy ions penetrating amorphous materials and single crystals at highly relativistic energies. The main component originates in scattering of the virtual photons of screened target...... in a pronounced directional dependence of the energy loss of bare heavy ions at extreme relativistic energies....

  19. Suppression of soft nuclear bremsstrahlung in proton-nucleus collisions

    International Nuclear Information System (INIS)

    Goethem, M.J. van; Bacelar, J.C.S.; Hoefman, M.; Huisman, H.; Kalantar-Nayestanaki, N.; Loehner, H.; Messchendorp, J.G.; Ostendorf, R.W.; Schadmand, S.; Siemssen, R.H.; Turrisi, R.; Volkerts, M.; Wilschut, H.W.; Aphecetche, L.; Delagrange, H.; D'Enterria, D.; Martinez, G.; Schutz, Y.; Diaz, J.; Holzmann, R.

    2002-01-01

    Photon energy spectra up to the kinematic limit have been measured in 190 MeV proton reactions with light and heavy nuclei to investigate the influence of the multiple-scattering process on the photon production. Relative to the predictions of models based on a quasifree production mechanism, a strong suppression of bremsstrahlung is observed in the low-energy region of the photon spectrum. We attribute this effect to the interference of photon amplitudes due to multiple scattering of nucleons in the nuclear medium

  20. Photonucleon reactions in 40Ca at intermediate energies

    International Nuclear Information System (INIS)

    Adler, J.-O.; Bulow, B.; Jonsson, G.G.; Lindgren, K.

    1976-01-01

    The yields of the reactions 40 Ca(γ,n) 39 Ca* and 40 Ca(γ,p) 39 K* to the first three excited states have been measured for bremsstrahlung with end-point energies in the region 100-750 MeV. The C 2 S values for the first excited state were deduced from the pion photoproduction contribution to the measured yields. (Auth.)

  1. Nonexistence of two forms of turbulent bremsstrahlung

    International Nuclear Information System (INIS)

    Kuijpers, J.; Melrose, D.B.

    1985-01-01

    It is shown that the forms of turbulent bremsstrahlung proposed by Tsytovich, Stenflo, and Wilhelmsson and by Nambu do not exist. The proposed mechanisms involve upconversion of ion sound turbulence into Langmuir turbulence, with the ion sound waves being emitted and absorbed resonantly and the Langmuir waves being emitted and absorbed nonresonantly. It is pointed out that a symmetry implicit in a standard QED treatment implies that there is another contribution to turbulent bremsstrahlung in addition to that calculated by Tsytovich, Stenflo, and Wilhelmsson and that the two contributions cancel exactly, leading to the null result. (Our arguments on this point have proved controversial.) Nambu made an approximation inconsistently, and when this approximation is not made, two terms in his analytic treatment cancel exactly. We argue that turbulent bremsstrahlung is related to a radiative correction in which the resonant emission of ion sound turbulence is modified by the nonresonant emission and absorption of Langmuir waves. Physically we interpret the nonexistence of turbulent bremsstrahlung as being due to each emission of a Langmuir quantum being associated with an absorption of an identical Langmuir quantum so that the Langmuir turbulence is unchanged. Proposed astrophysical applications of turbulent bremsstrahlung need to be reconsidered

  2. Limits for an inverse bremsstrahlung origin of the diffuse Galactic soft gamma-ray emission

    DEFF Research Database (Denmark)

    Pohl, M.

    1998-01-01

    origin of the soft Galactic gamma-ray continuum through inverse bremsstrahlung. A flux of low-energy cosmic rays strong enough to produce the observed spectrum of gamma-rays implies substantial gamma-ray emission at a few MeV through nuclear de-excitation. It is shown that the existing limits on excess 3......-7 MeV emission from the Galactic plane, in concert with the constraints from pi(0)-decay gamma-ray emission at higher energies, are in serious conflict with an inverse bremsstrahlung origin of the Galactic soft gamma-ray emission for any physically plausible low-energy cosmic ray spectrum. While...

  3. Bremsstrahlung scattering calculations for the beam stops and collimators in the APS insertion-device beamlines

    International Nuclear Information System (INIS)

    Job, P.K.; Haeffner, D.R.; Shu, D.

    1994-12-01

    Bremsstrahlung is produced in the APS storage ring by the interaction of positrons with the residual gas molecules in the vacuum chamber of the storage ring. The bremsstrahlung production causes a serious challenge in shielding the insertion-device beamlines because the entire straight section (15 meters) is in the line of sight of the beamline. The radiation emerges in a narrow cone tangential to the beam path with the characteristic emission angle 1/γ, where γ is E/mc 2 which is the ratio of the kinetic energy to the rest mass for the positrons. This high-energy gamma radiation has an approximate 1/E spectrum with the maximum energy extending up to the particle energy (7 GeV for the APS). Bremsstrahlung, being high-energy photons, produces an electromagnetic shower when it encounters the beamline elements. A beamline element not thick enough to fully contain an electromagnetic shower can cause considerable scatter of the high-energy bremsstrahlung radiation. The low-energy component of the bremsstrahlung can also be scattered and create high dose rates in the first-optical and white-beam enclosures. The fully developed electromagnetic shower will have a photon spectrum almost independent of the material. The electromagnetic showers in the high-Z materials can also produce photoneutrons. This note reports the summary of EGS4 calculations performed on bremsstrahlung scattering from different beamline components in a typical APS insertion-device beamline. The related recommendations for shielding are also given. The shielding criterion adopted is a total dose rate of 2.5μSv/h (0.25 mrem/h) at 30 cm from the shield

  4. Evaluating the therapeutic effect of 89Sr using Bremsstrahlung imaging in patients with bone metastases

    International Nuclear Information System (INIS)

    Zhang Daping; Lou Cen; Chen Liang; Yu Linliang; Huang Huacheng

    2003-01-01

    Objective: To evaluate the therapeutic effect of 89 Sr (a pure beta emitter) using Bremsstrahlung imaging in patients with multiple bone metastases. Methods: 89 Sr Bremsstrahlung imaging was performed 1-2 weeks after injection in 14 patients with bone metastases, using GE Camstar 3200 SPECT equipped with a medium-energy collimator. To improve resolution of imaging, authors selected suitable energy level and wide window width (a 95-100% energy window around 100 KeV). Results: Abnormal uptake was seen in all and was consistent with the results of 99m Tc-MDP imaging. According to this result, authors can realize localization, retention and metabolism of 89 Sr in body. Conclusion: Bremsstrahlung imaging is useful for clinical observation and estimating the curative effect and prognosis in pure beta emitter therapy such as 89 Sr. In addition, it can be helpful in determining dose of 89 Sr if a repeated therapy is needed

  5. Prediction of the relative toxicity of environmental toxins as a function of behavioral and non-behavioral endpoints

    International Nuclear Information System (INIS)

    Young, R.W.

    1979-01-01

    This study was conducted in order to examine the differential effects of behavioral and non-behavioral endpoints on the prediction of the relative toxicity of an environmental toxin. The effects of ionizing radiation were taken as the model for this evaluation. Forty rhesus monkeys were irradiated in groups of four at five different dose levels of high energy neuton and Bremsstrahlung radiations. Measures of behavioral performance, emesis and mortality were taken for each subject in order to test the hypotheses that behavioral indices would be more sensitive to gamma radiation than would physiological indices and that the physiological indices would be more sensitive to neutron radiations than would behavioral indices. The results supported these hypotheses

  6. Inner bremsstrahlung accompanying β-decay of 170Tm

    International Nuclear Information System (INIS)

    Gundu Rao, K.S.; Venkataramaiah, P.; Gopala, K.; Sanjeeviah, H.

    1981-01-01

    Inner bremsstrahlung accompanying non-unique first-forbidden β-decay of 170 Tm has been measured employing a magnetic deflection technique with a (4.5 x 5.1 cm) NaI(Tl) scintillation spectrometer in the energy region 200 keV to 900 keV. The raw spectrum is unfolded using the Liden and Starfelt procedure, and compared with the theories of KUB, Lewis and Ford, and Ford and Martin. The results are close to the Lewis and Ford theory over the major portion of the measured spectrum. (orig.)

  7. TBI Endpoints Development

    Science.gov (United States)

    2015-10-01

    therapy , and early mild physical activity, which result in fewer symptoms, lower mean severity of symptoms, less social disability, and fewer days off work...developing more precise TBI diagnostic tools, clinical endpoints, and effective therapies . We designed and executed an interactive program that combined...surgery, neuropsychology, neuroradiology, psychiatry, neurology, sports medicine, pediatrics, geriatrics , health economics, biostatistics, and informatics

  8. Practice for dosimetry in electron and bremsstrahlung irradiation facilities for food processing. 2. ed.

    International Nuclear Information System (INIS)

    2002-01-01

    This practice describes dosimetric procedures to be followed in facility characterization, process qualification, and routine processing for electron beam and bremsstrahlung irradiation facilities for food processing to ensure that product receives an acceptable range of absorbed doses. Other procedures related to facility characterization, process qualification, and routine product processing that may influence and be used to monitor absorbed dose in the product are also discussed. Information about effective or regulatory dose limits for food products is not within the scope of this practice (see ASTM Guides F 1355 and F 1356). The electron energy range covered in this practice is from 0.3 MeV to 10 MeV. Such electrons can be generated in continuous or pulse modes. The maximum electron energy of bremsstrahlung facilities covered in this practice is 10 MeV. A photon beam can be generated by inserting a bremsstrahlung converter in the electron beam path (See ISO/ASTM Practice 51608

  9. Internal bremsstrahlung signatures in light of direct dark matter searches

    Energy Technology Data Exchange (ETDEWEB)

    Garny, Mathias [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Ibarra, Alejandro; Pato, Miguel; Vogl, Stefan [Technische Univ. Muenchen, Garching (Germany). Physik Dept. T30d

    2013-06-15

    Although proposed long ago, the search for internal bremsstrahlung signatures has only recently been made possible by the excellent energy resolution of ground-based and satellite-borne gamma-ray instruments. Here, we investigate thoroughly the current status of internal bremsstrahlung searches in light of the results of direct dark matter searches and in the framework of minimal mass-degenerate scenarios. The constraints set by Fermi-LAT and H.E.S.S. extend uninterrupted from tens of GeV up to tens of TeV and are rather insensitive to the mass degeneracy in the particle physics model. In contrast, direct searches are best in the moderate to low mass splitting regime, where XENON100 limits overshadow Fermi-LAT and H.E.S.S. up to TeV masses if dark matter couples to (light) quarks. We examine carefully the prospects for GAMMA-400, CTA and XENON1T, all planned to come online in the near future, and find that: (a) CTA and XENON1T are fully complementary, with CTA most sensitive to multi-TeV masses and mass splittings around 10%, and XENON1T probing best small mass splittings up to TeV masses; and (b) current constraints from XENON100 already preclude the observation of any spectral feature with GAMMA-400 in spite of its impressive energy resolution, unless dark matter does not couple to light quarks. Finally, we point out that, unlike for direct searches, the possibility of detecting thermal relics in upcoming internal bremsstrahlung searches requires boost factors larger than {proportional_to}10.

  10. Internal bremsstrahlung signatures in light of direct dark matter searches

    International Nuclear Information System (INIS)

    Garny, Mathias; Ibarra, Alejandro; Pato, Miguel; Vogl, Stefan

    2013-07-01

    Although proposed long ago, the search for internal bremsstrahlung signatures has only recently been made possible by the excellent energy resolution of ground-based and satellite-borne gamma-ray instruments. Here, we investigate thoroughly the current status of internal bremsstrahlung searches in light of the results of direct dark matter searches and in the framework of minimal mass-degenerate scenarios. The constraints set by Fermi-LAT and H.E.S.S. extend uninterrupted from tens of GeV up to tens of TeV and are rather insensitive to the mass degeneracy in the particle physics model. In contrast, direct searches are best in the moderate to low mass splitting regime, where XENON100 limits overshadow Fermi-LAT and H.E.S.S. up to TeV masses if dark matter couples to (light) quarks. We examine carefully the prospects for GAMMA-400, CTA and XENON1T, all planned to come online in the near future, and find that: (a) CTA and XENON1T are fully complementary, with CTA most sensitive to multi-TeV masses and mass splittings around 10%, and XENON1T probing best small mass splittings up to TeV masses; and (b) current constraints from XENON100 already preclude the observation of any spectral feature with GAMMA-400 in spite of its impressive energy resolution, unless dark matter does not couple to light quarks. Finally, we point out that, unlike for direct searches, the possibility of detecting thermal relics in upcoming internal bremsstrahlung searches requires boost factors larger than ∝10.

  11. Probing few-body systems with bremsstrahlung

    NARCIS (Netherlands)

    Kalantar-Nayestanaki, N; Kruppa, AT; Lovas, RG

    2002-01-01

    A series of bremsstrahlung measurements have been performed with the superconducting cyclotron, AGOR, at KVI. These measurements, on the proton-proton and proton-deuteron systems, aim to investigate the nucleon-nucleon interaction as the nucleons go off their mass shell. Cross sections and analyzing

  12. Probing few-body systems with bremsstrahlung

    NARCIS (Netherlands)

    Kalantar-Nayestanaki, N; Krivec, R; Golli, B; Rosina, M; Sirca, S

    2003-01-01

    A series of bremsstrahlung measurements have been performed with the superconducting cyclotron, AGOR, at KVI. These measurements, on the proton-proton and proton-deuteron systems, aim to investigate the nucleon-nucleon interaction far away from elastic channel. Cross sections and analyzing powers

  13. Probing few-body systems with bremsstrahlung

    NARCIS (Netherlands)

    Kalantar-Nayestanaki, N; Oryu, S; Kamimura, M; Ishikawa, S

    2000-01-01

    A series of bremsstrahlung measurements have been performed with the superconducting cyclotron, AGOR, at KVI. These measurements, on the proton-proton and proton-deuteron systems, aim to investigate the nucleon-nucleon interaction as the nucleons go off their mass shelf. Cross sections and analyzing

  14. Bremsstrahlung in electron-positronium scattering

    International Nuclear Information System (INIS)

    Amusia, M.Ya.; Korol, A.V.; Solovyov, A.V.

    1986-01-01

    The spectrum of radiation formed in the fast nonrelativistic electron scattering on positronium is calculated. It is shown that all the radiation proceeds via virtual positronium deformations during the collision. An essential difference of bremsstrahlung spectra in electron on positronium and electron on hydrogen scattering is demonstrated. (orig.)

  15. Hazardous waste transportation risk assessment for the US Department of Energy Environmental Restoration and Waste Management Programmatic Environmental Impact Statement -- human health endpoints

    International Nuclear Information System (INIS)

    Hartmann, H.M.; Policastro, A.J.; Lazaro, M.A.

    1994-01-01

    In this presentation, a quantitative methodology for assessing the risk associated with the transportation of hazardous waste (HW) is proposed. The focus is on identifying air concentrations of HW that correspond to specific human health endpoints

  16. The bremsstrahlung tagged photon beam in Hall B at JLab

    CERN Document Server

    Sober, D I; Longhi, A; Matthews, S K; O'Brien, J T; Berman, B L; Briscoe, W J; Cole, P L; Connelly, J P; Dodge, W R; Murphy, L Y; Philips, S A; Dugger, M K; Lawrence, D; Ritchie, B G; Smith, E S; Lambert, J M; Anciant, E; Audit, G; Auger, T; Marchand, C; Klusman, M; Napolitano, J; Khandaker, M A; Salgado, C W; Sarty, A J

    2000-01-01

    We describe the design and commissioning of the photon tagging beamline installed in experimental Hall B at the Thomas Jefferson National Accelerator Facility (JLab). This system can tag photon energies over a range from 20% to 95% of the incident electron energy, and is capable of operation with beam energies up to 6.1 GeV. A single dipole magnet is combined with a hodoscope containing two planar arrays of plastic scintillators to detect energy-degraded electrons from a thin bremsstrahlung radiator. The first layer of 384 partially overlapping small scintillators provides photon energy resolution, while the second layer of 61 larger scintillators provides the timing resolution necessary to form a coincidence with the corresponding nuclear interaction triggered by the tagged photon. The definitions of overlap channels in the first counter plane and of geometric correlation between the two planes are determined using digitized time information from the individual counters. Auxiliary beamline devices are briefl...

  17. Contribution of 210Pb bremsstrahlung to the background of lead shielded gamma spectrometers

    International Nuclear Information System (INIS)

    Mrda, D.; Bikit, I.; Veskovic, M.; Forkapic, S.

    2007-01-01

    Lead, which is often used as a shielding material, contains 210 Pb (T 1/2 =22.3 y). The 46.54 keV γ-intensity of 210 Pb can be easily reduced by an inner lining, but the bremsstrahlung caused by the β-decay of its daughter, 210 Bi, with a maximal electron energy of 1.16 MeV, will contribute to the gamma detector background. The spectrum of this bremsstrahlung is calculated by numerically fitting the β-spectrum and integrating the Koch-Motz formula. The absorption of the bremsstrahlung in the lead and detection efficiencies for the HPGe detector are calculated by the effective solid angle algorithm, using corrections for the photopeak/Compton ratio of cross-sections in Ge. By comparison with the measured background spectrum, it is shown that, for the lead with 25 Bq/kg of 210 Pb up to 500 keV of gamma spectrum, the bremsstrahlung contribution to the background is about 20% for our surface-based detector system. Also, we compared our calculations with a Monte Carlo simulation of another detector system with a shield containing 1 Bq/kg of 210 Pb and found that our analytical method gives a value of roughly two times higher than the Monte Carlo one for the total bremsstrahlung contribution. The quality of the analytical semi-empirical method is proved by the reasonable agreement with the experimental results published

  18. Comparison of different Bremsstrahlung converters and collimators for Nuclear Resonance Fluorescence setup at IFUSP

    International Nuclear Information System (INIS)

    Lopez, P.N; Corrales, Y.; Manso Guevara, M.V; Martins, M.N.

    2007-01-01

    Nuclear Resonance Fluorescence (NRF) setup will install in the new electron accelerator, which is in final stage of installation at the Physics Institute of Sao Paulo University (IFUSP). The Bremsstrahlung facility and the setup for photon scattering should be designed such that the background radiation caused by scattering photons and the production of neutrons is minimized. In this order the Monte Carlo simulation studies show the best options for the different elements of the NRF setup, and how to link these elements to the particularities of the irradiation room. In the present stage the simulations has been included the studies of different Bremsstrahlung converters and collimators. Several materials (Ta, W, Au, Nb, Cu) for Bremsstrahlung converters were studied. Detailed analyses of intensity as well as the opening angles of Bremsstrahlung radiation were carried out, for different converter thickness. For the collimator two materials (Cu and Pb) were studied in the simulations. Several opening angles and thickness (40 - 100 cm) were studied. The Bremsstrahlung beam collimation for different energy bins, and the photon scattering from the collimator ,were used as quality parameters of the collimators. (Author)

  19. Bremsstrahlung emission probability in the {alpha} decay of {sup 210}Po

    Energy Technology Data Exchange (ETDEWEB)

    Boie, Hans-Hermann

    2009-06-03

    A high-statistics measurement of bremsstrahlung emitted in the {alpha} decay of {sup 210}Po has been performed. The measured differential emission probabilities, which could be followed up to {gamma}-energies of {proportional_to} 500 keV, allow for the first time for a serious test of various model calculations of the bremsstrahlung accompanied {alpha} decay. It is shown that corrections to the {alpha}-{gamma} angular correlation due to the interference between the electric dipole and quadrupole amplitudes and due to the relativistic character of the process have to be taken into account. With the experimentally derived angular correlation the measured energydifferential bremsstrahlung emission probabilities show excellent agreement with the fully quantum mechanical calculation. (orig.)

  20. Measurement of activity yields for 12C(#betta#, n)11C, 14N(#betta#, n)13N, and 16O(#betta#, n)15O reactions as a function of electron beam energy and angle from the electron beam using thick target produced bremsstrahlung

    International Nuclear Information System (INIS)

    Piltingsrud, H.V.

    1983-01-01

    The calculation of activity yields from practical photonuclear target systems designed to produce short-lived positron emitting radionuclides for nuclear medicine purposes requires certain basic information. These include a knowledge of the photon source (bremsstrahlung energy spectrum and intensity as a function of angle from the electron beam) and the #betta#, n activation cross section of the secondary target element. A lack of adequate information concerning these parameters motivated the present study in which activity yields for the reactions 12 C(#betta#, n) 11 C, 14 N(#betta#, n) 13 N, and 16 O(#betta#, n) 15 O were measured as a function of energy of and angle from the electron beam between 16 and 30 MeV and 0 0 and 30.5 0 , respectively. The data indicate highly complex relationships between the activity yield and the experimental variables. Also indicated are possible applications of the data to indicate the energy of an electron beam producing a given bremsstrahlung field in which activation measurements are made

  1. The Schiff angular bremsstrahlung distribution from composite media

    International Nuclear Information System (INIS)

    Taylor, M.L.; Dalton, B.; Franich, R.D.

    2012-01-01

    The Schiff differential for the angular distribution of bremsstrahlung is widely employed, but calculations involving composite materials (i.e. compounds and mixtures) are often undertaken in a somewhat ad hoc fashion. In this work, we suggest an alternative approach to power-law estimates of the effective atomic number utilising Seltzer and Berger’s combined approach in order to generate single-valued effective atomic numbers applicable over a large energy range (in the worst case deviation from constancy of about 2% between 10 keV and 1 GeV). Differences with power-law estimates of Z for composites are potentially significant, particularly for low-Z media such as biological or surrogate materials as relevant within the context of medical physics. As an example, soft tissue differs by >70% and cortical bone differs by >85%, while for high-Z composites such as a tungsten–rhenium alloy the difference is of the order of 1%. Use of the normalised Schiff formula for shape only does not exhibit strong Z dependence. Consequently, in such contexts the differences are negligible – the power-law approach overestimates the magnitude by 1.05% in the case of water and underestimates it by <0.1% for the high-Z alloys. The differences in the distribution are most pronounced for small angles and where the bremsstrahlung quanta are low energy.

  2. Modeling of the electron distribution based on bremsstrahlung emission during lower hybrid current drive on PLT

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, J.E.; von Goeler, S.; Bernabei, S.; Bitter, M.; Chu, T.K.; Efthimion, P.; Fisch, N.; Hooke, W.; Hosea, J.; Jobes, F.

    1985-03-01

    Lower hybrid current drive requires the generation of a high energy electron tail anisotropic in velocity. Measurements of bremsstrahlung emission produced by this tail are compared with the calculated emission from reasonable model distributions. The physical basis and the sensitivity of this modeling process are described and the plasma properties of current driven discharges which can be derived from the model are discussed.

  3. Measurement of the linear polarization of the photons in the elementary processes of bremsstrahlung production

    International Nuclear Information System (INIS)

    Bleier, W.

    1983-01-01

    The polarization of the photons in the elementary processes of the electron-nucleus and electron-electron bremsstrahlung was measured. Electrons with an energy of 300 keV were scattered by copper, gold and carbon target. The polarization in the different processes was measured by using different coincidence methods. (BEF)

  4. Modeling of the electron distribution based on bremsstrahlung emission during lower hybrid current drive on PLT

    International Nuclear Information System (INIS)

    Stevens, J.E.; von Goeler, S.; Bernabei, S.

    1985-03-01

    Lower hybrid current drive requires the generation of a high energy electron tail anisotropic in velocity. Measurements of bremsstrahlung emission produced by this tail are compared with the calculated emission from reasonable model distributions. The physical basis and the sensitivity of this modeling process are described and the plasma properties of current driven discharges which can be derived from the model are discussed

  5. 200-MeV bremsstrahlung tagged photon beams at Sendai

    International Nuclear Information System (INIS)

    Hirose, K.; Chiba, M.; Inoue, M.; Kanda, H.; Kimura, R.; Kino, K.; Kobayashi, Y.; Konno, O.; Maeda, K.; Miyase, H.; Miyamoto, A.; Ohtsuki, T.; Saito, A.; Suda, T.; Takahashi, K.; Tamae, T.; Terasaki, Y.; Terasawa, T.; Tsubota, H.; Tsuruta, T.; Utoyama, M.; Yuuki, H.; Yamaguchi, Y.; Yamazaki, H.

    2006-01-01

    A new beam line for photonuclear reaction experiments using tagged photons has been constructed to take advantage of the completion of the 1.2-GeV STretcher Booster (STB) ring at the Laboratory of Nuclear Science (LNS), Tohoku University. A photon tagging system was installed at the end of the new beam line. It provides bremsstrahlung tagged photon beams in an energy range from 0.2E 0 to 0.8E 0 MeV at the incident electron energy E 0 with an energy resolution of ΔE/E∼10 -2 . The tagged photon intensity I= 6 photons/s is available for typical photonuclear reaction experiments. We introduce the basic parameters of the tagged photons by showing the commissioning data

  6. A high resolution beam profile monitor using Bremsstrahlung

    International Nuclear Information System (INIS)

    Norem, J.

    1988-01-01

    The development of efficient high energy linear colliders in the 1 TeV range requires final focus systems capable of producing beam spot sizes on the order of 1--20 nm, about three orders of magnitude smaller than those produced at the SLC. Although beam line designs exist which can, in principle, produce the required optics, the construction of quadrupoles with the size and precision required will be challenging. Field errors in these quads must be small and should be verified experimentally, which is difficult with existing technology. This paper describes a proposal to use bremsstrahlung from heavy targets to measure high energy beam profiles and positions with a resolution approaching a few nm. The method is also applicable to tests of other final focus systems (flat beams, plasma lenses) at lower energies. 6 refs., 3 figs., 1 tab

  7. Internal Bremsstrahlung accompanying beta decay of 90 Y

    International Nuclear Information System (INIS)

    Elsayed, A.M.A.; Abdelhady, E.E.

    1992-01-01

    The internal Bremsstrahlung (IB) spectrum associated with the unique first-forbidden β decay of 9 0Y is measured employing the conventional β-stopper technique with a 5 x 5 cm NaI (T 1) scintillation spectrometer in the energy range (50-2000 keV). All the necessary corrections are made. In order to analyze the experimental data, a response matrix having the dimensions of 64 energy bins and 474 channels is constructed.with the help of the detector assembly response matrix, the true IB energy spectrum is obtained by iteratively unfolding the experimental pulse-height spectrum. The experimental results are compared with the corresponding theoretical distributions due to Knipp and Uhlenbeck and Bloch (KUB), lewis and ford (L F), and ford and martin (FM). The results show reasonable agreement with the detour theory of ford and martin.3 fig

  8. 'Atomic Bremsstrahlung': Retrospectives, current status and perspectives

    International Nuclear Information System (INIS)

    Amusia, M.Ya.

    2006-01-01

    We describe here the 'Atomic bremsstrahlung' (AB)-emission of continuous spectrum electromagnetic radiation, which is generated in collisions of particles that have internal deformable structure that includes positively and negatively charged constituents. The deformation of one or both colliding partners induces multiple, mainly dipole, time-dependent electrical moments that become a source of radiation. The history of AB invention is presented and its unusual in comparison to ordinary bremsstrahlung (OB) properties, are discussed. As examples, fast electron atom, non-relativistic and relativistic collisions are considered. Attention is given to ion-atom and atom-atom collisions. Specifics of 'elastic' and 'inelastic' (i.e. radiation accompanied by destruction of collision partners) AB will be mentioned. Attention will be given to possible manifestation of AB in nature and in some exotic systems, for instance scattering of electrons upon muonic hydrogen. Some cooperative effects connected to AB will be considered. New classical schemes similar to AB will be presented

  9. Effects of a neutral current on the neutrino bremsstrahlung

    International Nuclear Information System (INIS)

    Ju, I.

    1977-01-01

    The energy-loss rate due to the neutrino bremsstrahlung from relativistic electrons in a dense matter such as a star is calculated in the framework of Weinberg's unified theory of weak and electromagnetic interactions by using the method of neutrino-energy expansion. The momentum-transfer integration, though complicated, can be carried out analytically, but the subsequent two electron integrals, called the distribution integrals, are helpless and do not allow any further analytic calculation. In order to avoid this difficulty, we set up a set of variables whose integration is simple enough to be expanded in series. It turns out that this series becomes a power series in the Fermi energy inverse after the distribution integrals. This enables us to keep only the leading terms, greatly simplifying the final result. Thus in principle we will be able to calculate arbitrary higher-order terms, even though most of them require prohibitively tedious labor. We carry out the next-higher-order calculations to find that the correction to the lowest-order contribution is within 5%. This confirms the earlier calculations of Festa and Ruderman, even though the two approaches are quite different: the neutrino-bremsstrahlung energy-loss rate is proportional to T 6 and independent of the density at extremely relativistic degenerate regions. We find that the asymptotic expression for the energy-loss rate is of the form A (β) + (rho/μ/sub e/) -1 / 3 kTB (β). The most striking effect of the neutral current is the muon-neutrino emission. The ratio of the energy-loss rate in Weinberg's theory to that in the conventional theory is 1/2 + 4 sin 4 theta/sub W/ at the extreme relativistic-degenerate and nondegenerate-nonrelativistic regions

  10. Bremsstrahlung doses from natural uranium ingots

    International Nuclear Information System (INIS)

    Anderson, J. L.; Hertel, N. E.

    2005-01-01

    In the past, some privately owned commercial facilities in the United States were involved in producing or processing radioactive materials used in the production of atomic weapons. Seven different geometrical objects, representative of the configurations of natural uranium metal potentially encountered by workers at these facilities, are modelled to determine gamma ray and Bremsstrahlung dose rates. The dose rates are calculated using the MCNP5 code and also by using the MICROSHIELD point-kernel code. Both gamma ray and Bremsstrahlung dose rates are calculated and combined to obtain a total dose rate. The two methods were found to be in good agreement despite differences in modelling assumptions and method differences. Computed total dose rates on the surface of these objects ranged from ∼51-84 μSv h -1 and 17-95 μSv h -1 using the MCNP5 and the MICROSHIELD modeling, respectively. The partitioning of the computed dose rates between gamma rays and Bremsstrahlung were the same order of magnitude for each object. (authors)

  11. Bremsstrahlung doses from natural uranium ingots.

    Science.gov (United States)

    Anderson, Jeri L; Hertel, Nolan E

    2005-01-01

    In the past, some privately owned commercial facilities in the United States were involved in producing or processing radioactive materials used in the production of atomic weapons. Seven different geometrical objects, representative of the configurations of natural uranium metal potentially encountered by workers at these facilities, are modelled to determine gamma ray and bremsstrahlung dose rates. The dose rates are calculated using the MCNP5 code and also by using the MICROSHIELD point-kernel code. Both gamma ray and bremsstrahlung dose rates are calculated and combined to obtain a total dose rate. The two methods were found to be in good agreement despite differences in modelling assumptions and method differences. Computed total dose rates on the surface of these objects ranged from approximately 51-84 microSv h(-1) and 17-95 microSv h(-1) using the MCNP5 and the MICROSHIELD modeling, respectively. The partitioning of the computed dose rates between gamma rays and bremsstrahlung were the same order of magnitude for each object.

  12. Bremsstrahlung of fast electrons in long air gaps

    Energy Technology Data Exchange (ETDEWEB)

    Oreshkin, E. V.; Barengolts, S. A. [P. N. Lebedev Physical Institute, RAS, 119991 Moscow (Russian Federation); General Physics Institute, RAS, 119991 Moscow (Russian Federation); Chaikovsky, S. A. [P. N. Lebedev Physical Institute, RAS, 119991 Moscow (Russian Federation); Institute of High Current Electronics, SB RAS, 634055 Tomsk (Russian Federation); Oginov, A. V.; Shpakov, K. V.; Bogachenkov, V. A. [P. N. Lebedev Physical Institute, RAS, 119991 Moscow (Russian Federation)

    2012-01-15

    The results of an experiment on discharges in long atmospheric pressure air gaps at a pulsed voltage of amplitude up to 800 kV and risetime 150-200 ns have been analyzed. In the experiment, a radiation pulse of photon energy >5 keV and duration 10-20 ns was observed. In analyzing the experimental data it was supposed that a streamer is a plasma protrusion whose surface is equipotential to the cathode surface. It has been shown that the x-ray pulse results from the switch of electrons into the mode of ''runaway'' from the head of anode-directed streamers. For the electrons injected in the electrode gap from the streamer head, conditions for their switching into the mode of continuous acceleration are realized due to the enhanced electric field at the head. The predicted maximum of the spectrum of the bremsstrahlung generated by the runaway electron beam is around 15 keV. The presence of a maximum in the bremsstrahlung spectrum is due to that the photons emitted by electrons are absorbed by atoms of the gas in which the discharge operate.

  13. Internal bremsstrahlung spectra from 185W and 32P

    International Nuclear Information System (INIS)

    Babu, R.P.; Murty, K.N.; Murty, V.A.N.

    1976-01-01

    The internal bremsstrahlung spectra from the β decay of 185 W and 32 P were measured using a NaI(Tl) scintillation spectrometer with a standard geometrical arrangement. After making all the necessary corrections the experimental results are compared with the allowed theory of the Knipp, Uhlenbeck, and Bloch (KUB theory) and also with the Coulomb corrected theories of Lewis, Ford, and Nilsson. In the case of 185 W it is found that from 78 to 200 keV the experimental distribution is in good agreement with the KUB theory whereas beyond 200 keV and below 78 keV the experimental points are far above even the highest Coulomb corrected theoretical distribution of Nilsson. The internal bremsstrahlung from this isotope has not been previously investigated. In the case of 32 P the experimental relative intensity spectrum is compared with the KUB theory and also with the Coulomb corrected theory of Lewis and Ford. Fairly good agreement is obtained from 30 to 200 keV with the KUB theory but in the energy region from 200 to 900 keV, the experimental results deviate positively from both the KUB and Lewis and Ford theories. The experimental excess over the Lewis and Ford theory is 15% on the average

  14. Post-Newtonian gravitational bremsstrahlung

    International Nuclear Information System (INIS)

    Turner, M.; Will, C.M.

    1977-07-01

    Formulae and numerical results are presented for the gravitational radiation emitted during a low-deflection encounter between two massive bodies. Results are valid through post-Newtonian order within general relativity. The gravitational waveform, the total luminosity and total emitted energy, the angular distribution of emitted energy, and the frequency spectrum are discussed in detail. A method boosting the accuracy of these quantities to post Newtonian order is also presented. A numerical comparison of results with those of Peters, and of Kovacs and Thorne shows that the post Newtonian method is reliable to better than 0.1 percent at v = 0.1 c, to a few percent at v = 0.35 c, and to 10 to 20 percent at v = 0.5 c

  15. Experimental results on 2-30 keV bremsstrahlung from thick and thin targets

    Energy Technology Data Exchange (ETDEWEB)

    Shanker, R. [Atomic Physics Laboratory, Physics Department, Banaras Hindu University, Varanasi 221005 (India)]. E-mail: rshanker@bhu.ac.in

    2006-10-15

    The recent experimental investigations on electron bremsstrahlung produced from impact of 2-30 keV electrons with thick solid and thin gaseous targets are reviewed. The theoretical models describing the energy and angular distributions of bremsstrahlung photons are discussed with their brief outlines and formulations to explain the experimental data. The results on thick target bremsstrahlung (TTB) spectra produced by keV electrons have suggested that there is a need to develop a comprehensive theory for accounting the solid state effects. It is further noted that the prediction of the modified KKD formula gives a reasonable agreement with the TTB data, whereas a semi-empirical formula gives a better fit to the data for thick targets. The available experimental data for dependence of double differential cross-sections of emitted photons on impact energy and their emission angles for gaseous atoms and molecules exhibit a good agreement with the theoretical calculations of Kissel et al., [1983. Shape functions for atomic-field bremsstrahlung from electrons of kinetic energy 1-500 keV on selected neutral atoms 1

  16. New knowledge about the bremsstrahlung image of strontium-89 with the scintillation camera

    International Nuclear Information System (INIS)

    Narita, Hiroto; Hirase, Kiyoshi; Uchiyama, Mayuki; Fukushi, Masahiro

    2012-01-01

    Strontium-89 ( 89 Sr) chloride has been used to treat metastases in bone. A method to visualize the distribution of 89 Sr chloride with a scintillation camera was developed in 1996. Studies using bremsstrahlung imaging have shown that 89 Sr accumulates in bone and that the bremsstrahlung generated from biological tissue surrounding bone does not exceed 30 keV. However, it was not clear how low-energy bremsstrahlung from bone can produce peak energy levels of around 75 keV. We speculate that a different (unidentified) factor is involved. The energy spectrum of an 89 Sr source was acquired with a scintillation camera with or without a low-to-medium-energy general-purpose collimator. The energy window was set at 20-650 keV for 4 windows. A 50-mm thick acrylic block was placed between the scintillation camera and the 89 Sr source to exclude the effects of bremsstrahlung. The energy spectrum of 89 Sr covered with lead was acquired using the scintillation camera without a collimator. With the collimator the energy spectrum curve was similar to that without the 50 mm of acrylic. The energy spectrum curve showed peaks at about 75, 170, and 520 keV. Without the collimator the energy spectrum showed a similar curve but no peak at 75 keV peak. The curve was similar to that obtained with the scintillation camera and the collimator; however, the curve obtained when the 89 Sr source had been placed in a lead container was similar to that obtained when the source was unshielded, and the collimator was not attached to the scintillation camera. If bremsstrahlung of 89 Sr produces an image, a low-energy spectrum region should decrease when acrylic is placed between the 89 Sr source and the scintillation camera. However, similar curves were obtained both with the acrylic in place and without the acrylic. Therefore, we believe that the radiation detected by the scintillation camera was not bremsstrahlung due to the beta rays of 89 Sr. Most 89 Sr preparations are contaminated by 85 Sr

  17. The double copy: Bremsstrahlung and accelerating black holes

    CERN Document Server

    Luna, Andres; Nicholson, Isobel; O'Connell, Donal; White, Chris D

    2016-01-01

    Advances in our understanding of perturbation theory suggest the existence of a correspondence between classical general relativity and Yang-Mills theory. A concrete example of this correspondence, which is known as the double copy, was recently introduced for the case of stationary Kerr-Schild spacetimes. Building on this foundation, we examine the simple time-dependent case of an accelerating, radiating point source. The gravitational solution, which generalises the Schwarzschild solution, includes a non-trivial stress-energy tensor. This stress-energy tensor corresponds to a gauge theoretic current in the double copy. We interpret both of these sources as representing the radiative part of the field. Furthermore, in the simple example of Bremsstrahlung, we determine a scattering amplitude describing the radiation, maintaining the double copy throughout. Our results provide the strongest evidence yet that the classical double copy is directly related to the BCJ double copy for scattering amplitudes.

  18. Internal Bremsstrahlung spectrum of 204TI in the X-ray region

    International Nuclear Information System (INIS)

    Raghavendra, M.K.; Ramaswamy, C.R.

    2001-01-01

    The internal Bremsstrahlung spectrum from 204 TI has been measured, using magnetic deflector method, in the X-ray region. The corrected spectral intensity is compared with the Coulomb-corrected KUB theory in the energy region of 10 to 30 keV. The good agreement between experiment and theory in this energy region, suggests that 'detour effects' are negligible in the low energy region. (author)

  19. Resonance double magnetic bremsstrahlung in a strong magnetic field

    International Nuclear Information System (INIS)

    Fomin, P.I.; Kholodov, R.I.

    2003-01-01

    The possibility of resonance double magnetic bremsstrahlung in the approximation of weakly excited electron states in a strong external magnetic field is analyzed. The differential probability of this process in the Breit-Wigner form is obtained. The probability of double magnetic bremsstrahlung (second-order process of perturbation theory) is compared with the probability of magnetic bremsstrahlung (first-order process of perturbation theory)

  20. A summation free β+-endpoint spectrometer

    International Nuclear Information System (INIS)

    Keller, H.; Kirchner, R.; Klepper, O.; Roeckl, E.; Schardt, D.; Simon, R.S.; Kleinheinz, P.; Liang, C.F.; Paris, P.

    1990-08-01

    A β + -endpoint spectrometer is described, where positrons are observed in an 11-mm thick silicon detector in coincidence with subsequent γ-rays meausred in a germanium detector, and where the summing of the positron energy with the annihilation radiation is prevented by detecting both 511-keV quanta in opposite segments of a BGO ring surrounding the silicon detector. The procedure of measuring and analyzing the data is outlined for the decay of the 11/2 - -isomer of 149 Tb; its endpoint energy is determined to be 1853(10) keV, in agreement with the literature. The accuracy and reliability of β + -endpoint measurements is discussed in comparison to the EC/β + -ratio method. (orig.)

  1. Weibel instability due to inverse bremsstrahlung absorption

    International Nuclear Information System (INIS)

    Bendib, A.; Bendib, K.; Bendib, A.; Bendib, K.; Sid, A.; Bendib, K.

    1997-01-01

    A new Weibel source due to the inverse bremsstrahlung absorption is presented. It has been shown that in homogeneous plasmas, this mechanism may drive strong collisionless Weibel modes with growth rates of order of γ∼10 11 s -1 and negligible group velocities. In the laser-produced plasmas, for short laser wavelengths (λ L 10 14 W/cm 2 ), this Weibel source is most efficient as the ones due to the heat flux and the plasma expansion. The useful scaling law of the convective e-foldings, with respect to the laser and the plasma parameters, is also derived. copyright 1997 The American Physical Society

  2. The LPM effect in sequential bremsstrahlung: dimensional regularization

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, Peter; Chang, Han-Chih [Department of Physics, University of Virginia,382 McCormick Road, Charlottesville, VA 22894-4714 (United States); Iqbal, Shahin [National Centre for Physics,Quaid-i-Azam University Campus, Islamabad, 45320 (Pakistan)

    2016-10-19

    The splitting processes of bremsstrahlung and pair production in a medium are coherent over large distances in the very high energy limit, which leads to a suppression known as the Landau-Pomeranchuk-Migdal (LPM) effect. Of recent interest is the case when the coherence lengths of two consecutive splitting processes overlap (which is important for understanding corrections to standard treatments of the LPM effect in QCD). In previous papers, we have developed methods for computing such corrections without making soft-gluon approximations. However, our methods require consistent treatment of canceling ultraviolet (UV) divergences associated with coincident emission times, even for processes with tree-level amplitudes. In this paper, we show how to use dimensional regularization to properly handle the UV contributions. We also present a simple diagnostic test that any consistent UV regularization method for this problem needs to pass.

  3. Channeling and coherent bremsstrahlung effects for relativistic positrons and electrons

    International Nuclear Information System (INIS)

    Walker, R.L.

    1976-01-01

    Channeling of positrons in single crystals of silicon was observed in transmission and scattering measurements for incident energies from 16 to 28 MeV. In addition, the spectral dependence upon crystal orientation of the forward coherent bremsstrahlung produced by beams of 28-MeV positrons and electrons incident upon a 5 μm thick single crystal of silicon was measured with a NaI photon spectrometer. Effects of channeling and perhaps of the nonvalidity of the first Born approximation were observed for beam directions near the [111] axis of the crystal, and coherent peaks near 0.5 MeV were observed for a compound interference direction, in agreement with first-order theoretical calculations. 32 fig

  4. Nonlinear Breit–Wheeler pair creation with bremsstrahlung γ rays

    Science.gov (United States)

    Blackburn, T. G.; Marklund, M.

    2018-05-01

    Electron–positron pairs are produced through the Breit–Wheeler process when energetic photons traverse electromagnetic fields of sufficient strength. Here we consider a possible experimental geometry for observation of pair creation in the highly nonlinear regime, in which bremsstrahlung of an ultrarelativistic electron beam in a high-Z target is used to produce γ rays that collide with a counter-propagating laser pulse. We show how the target thickness may be chosen to optimize the yield of Breit–Wheeler positrons, and verify our analytical predictions with simulations of the cascade in the material and in the laser pulse. The electron beam energy and laser intensity required are well within the capability of today’s high-intensity laser facilities.

  5. Laser radiography forming bremsstrahlung radiation to image an object

    Science.gov (United States)

    Perry, Michael D.; Sefcik, Joseph A.

    2004-01-13

    A method of imaging an object by generating laser pulses with a short-pulse, high-power laser. When the laser pulse strikes a conductive target, bremsstrahlung radiation is generated such that hard ballistic high-energy electrons are formed to penetrate an object. A detector on the opposite side of the object detects these electrons. Since laser pulses are used to form the hard x-rays, multiple pulses can be used to image an object in motion, such as an exploding or compressing object, by using time gated detectors. Furthermore, the laser pulses can be directed down different tubes using mirrors and filters so that each laser pulse will image a different portion of the object.

  6. Neutron-proton bremsstrahlung studies using the white neutron source at the LAMPF/WNR

    International Nuclear Information System (INIS)

    Wender, S.A.; Nelson, R.O.; Schillaci, M.E.; Blann, M.

    1990-01-01

    Nucleon-nucleon bremsstrahlung is a few-body radiative process that provides insight into several areas of nuclear physics. It is one of the simplest systems for studying the off-shell behavior of the nucleon-nucleon potential. The physics involved in neutron-proton bremsstrahlung (NPB) is significantly different from that of proton-proton bremsstrahlung (PPB). In particular, NPB cross sections are much larger than PPB cross sections because NPB allows E1 radiation, and the contribution to the cross section from the meson exchange currents has been calculated to be as large as the contributions from external radiation. To date there have been essentially four NPB experiments. These measurements have covered only a small part of the available phase space. A major experimental problem in performing these measurements has been the lack of a suitable intense, high-energy neutron beam. We are planning a measurement of the NPB cross section using the white neutron source at the WNR target area at the LAMPF accelerator. We plant to implement the experiment in three phases. In this first state, we shall measure inclusive hard-photon production using a multi-element gamma-ray telescope that is insensitive to neutrons. In the second phase, we shall measure the bremsstrahlung gamma-rays in coincidence with recoil protons. In the last phase, we shall detect the scattered neutrons in coincidence with the recoil protons and gamma rays. 8 refs., 6 figs

  7. The bremsstrahlung induced by 0.3-2 keV electron scattering by Ar atoms

    International Nuclear Information System (INIS)

    Gnatchenko, E.V.; Tkachenko, A.A.; Verkhovtseva, E.T.

    2002-01-01

    The differential spectra of a bremsstrahlung resulting from a 0.3-2 keV electron scattering by Ar atoms are studied. Photon energies within the ultrasoft X-ray band from 124 to 190.8 eV, which is characterized by the low dynamic polarizability of the Ar atom, are considered. For the entire spectrum of photon energies (124-190.8 eV), the intensity of the bremsstrahlung differential spectra first grows with an increase in the electron energy from 0.3 to 0.7 keV and then decreases as the electron energy increases from 0.7 to 2 keV. The increase in intensity is directly proportional, and the decrease is inversely proportional to the square root of the energy of the scattered electrons. Within the context of a 'low-energy' approximation, the increase in the number of photons with the electron energy is due to the contribution of the atomic excitation and ionization channels being available during the bremsstrahlung process

  8. Photoactivation of the p-nucleus 92Mo at the bremsstrahlung measurement place of ELBE

    International Nuclear Information System (INIS)

    Erhard, Martin Andreas

    2010-01-01

    By the high intensity of the bremsstrahlung of up to 20 MeV to 10 9 MeV -1 cm -2 s -1 in the energy range up to 20 MeV in the framework of this thesis for the first time not only the (γ,n), but also the (γ,p) reactions could be studied on 92 Mo at astrophysically relevant energies.

  9. Impact of internal bremsstrahlung on the detection of γ rays from neutralinos

    International Nuclear Information System (INIS)

    Cannoni, M.; Gomez, M. E.; Sanchez-Conde, M. A.; Prada, F.; Panella, O.

    2010-01-01

    We present a detailed study of the effect of internal bremsstrahlung photons in the context of the minimal supersymmetric standard models and their impact on γ-ray dark matter annihilation searches. We find that, although this effect has to be included for the correct evaluation of fluxes of high energy photons from neutralino annihilation, its contribution is relevant only in models and at energies where the lines contribution is dominant over the secondary photons. Therefore, we find that the most optimistic supersymmetric scenarios for dark matter detection do not change significantly when including the internal bremsstrahlung. As an example, we review the γ-ray dark matter detection prospects of the Draco dwarf spheroidal galaxy for the MAGIC stereoscopic system and the CTA project. Though the flux of high energy photons is enhanced by an order of magnitude in some regions of the parameter space, the expected fluxes are still much below the sensitivity of the instruments.

  10. Shared Contract-Obedient Endpoints

    Directory of Open Access Journals (Sweden)

    Étienne Lozes

    2012-12-01

    Full Text Available Most of the existing verification techniques for message-passing programs suppose either that channel endpoints are used in a linear fashion, where at most one thread may send or receive from an endpoint at any given time, or that endpoints may be used arbitrarily by any number of threads. The former approach usually forbids the sharing of channels while the latter limits what is provable about programs. In this paper we propose a midpoint between these techniques by extending a proof system based on separation logic to allow sharing of endpoints. We identify two independent mechanisms for supporting sharing: an extension of fractional shares to endpoints, and a new technique based on what we call reflexive ownership transfer. We demonstrate on a number of examples that a linear treatment of sharing is possible.

  11. Bremsstrahlung parameters of praseodymium-142 in different human tissues. A dosimetric perspective for 142Pr radionuclide therapy

    International Nuclear Information System (INIS)

    Bakht, M.K.; Jabal-Ameli, H.; Ahmadi, S.J.; Sadeghi, M.; Sadjadi, S.; Tenreiro, Claudio

    2012-01-01

    Praseodymium-142 [T 1/2 =19.12 h, E β -=2.162 MeV (96.3%), E γ =1575 keV (3.7%)] is one of the 141 Pr radioisotopes. Many studies have been attempted to assess the significance of usage 142 Pr in radionuclide therapy. In many studies, the dosimetric parameters of 142 Pr sources were calculated by modeling 142 Pr sources in the water phantom and scoring the energy deposited around it. However, the medical dosimetry calculations in water phantom consider Bremsstrahlung production, raising the question: ''How important is to simulate human tissues instead of using water phantom?'' This study answers these questions by estimation of 142 Pr Bremsstrahlung parameters. The Bremsstrahlung parameters of 142 Pr as therapeutic beta nuclides in different human tissues (adipose, blood, brain, breast, cell nucleus, eye lens, gastrointestinal tract, heart, kidney, liver, lung deflated, lymph, muscle, ovary, pancreas, cartilage, red marrow, spongiosa, yellow marrow, skin, spleen, testis, thyroid and different skeleton bones) were calculated by extending the national council for radiation protection model. The specific Bremsstrahlung constant (Γ Br ), probability of energy loss by beta during Bremsstrahlung emission (P Br ) and Bremsstrahlung activity (A release ) Br were estimated. It should be mentioned that Monte Carlo simulation was used for estimation of 142 Pr Bremsstrahlung activity based on the element compositions of different human tissues and the calculated exposures from the anthropomorphic phantoms. Γ Br for yellow marrow was smallest amount (1.1962 x 10 -3 C/kg-cm 2 /MBq-h) compared to the other tissues and highest for cortical bone (2.4764 x 10 -3 C/kg-cm 2 /MBq-h), and, overall, Γ Br for skeletal tissues were greater than other tissues. In addition, Γ Br breast was 1.8261 x 10 -3 C/kg-cm 2 /MBq-h which was greater than sacrum and spongiosa bones. Moreover, according to (A release ) Br of 142 Pr, the patients receiving 142 Pr do not have to be hospitalized for

  12. High-resolution x-ray spectroscopy of coherent bremsstrahlung fine structure

    International Nuclear Information System (INIS)

    Lund, M.W.

    1989-01-01

    The aim of this research was to provide experimental evidence for fine structure due to umklapp by distinct reciprocal lattice vectors in coherent bremsstrahlung spectra. The spontaneous emission of photons by relativistic electrons transversing thin crystals is made possible by recoil of the crystal, which absorbs momentum in multiples of ℎG where G is a reciprocal lattice vector. Previous work in the MeV-GeV beam energy range used detectors whose energy resolution was greater than 10%. By fitting a Johann wavelength dispersive spectrometer to a transmission electron microscope the author obtained coherent bremsstrahlung spectra of very high quality with energy resolution of 1%. Important to this result were also the fine angular collimation, small energy width of the electron beam in the microscope, and the accurate control of crystal orientation possible in a modern goniometer stage. The theory of the design of bent crystal x-ray spectrometers is extended to include effects of defocus and aberrations. The theory for diffraction from a stationary three dimensional grating due to a dipole radiator moving at relativistic speeds is derived as well as several other broadening mechanisms stemming from experimental variables. This dissertation provides the first experimental observations and corresponding theoretical background for the fine structure of coherent bremsstrahlung due to umklapp by different G-vectors in the same reciprocal lattice plane

  13. Accuracy improvement of the laplace transformation method for determination of the bremsstrahlung spectra in clinical accelerators

    International Nuclear Information System (INIS)

    Scheithauer, M.; Schwedas, M.; Wiezorek, T.; Wendt, T.

    2003-01-01

    The present study focused on the reconstruction of the bremsstrahlung spectrum of a clinical linear accelerator from the measured transmission curve, with the aim of improving the accuracy of this method. The essence of the method was the analytic inverse Laplace transform of a parameter function fitted to the measured transmission curve. We tested known fitting functions, however they resulted in considerable fitting inaccuracy, leading to inaccuracies of the bremsstrahlung spectrum. In order to minimise the fitting errors, we employed a linear combination of n equations with 2n-1 parameters. The fitting errors are now considerably smaller. The measurement of the transmission function requires that the energy-dependent detector response is taken into account. We analysed the underlying physical context and developed a function that corrects for the energy-dependent detector response. The factors of this function were experimentally determined or calculated from tabulated values. (orig.) [de

  14. Vector dark matter annihilation with internal bremsstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Bambhaniya, Gulab, E-mail: gulab@prl.res.in [Physical Research Laboratory, Ahmedabad 380009 (India); Kumar, Jason, E-mail: jkumar@hawaii.edu [Department of Physics & Astronomy, University of Hawaii, Honolulu, HI 96822 (United States); Marfatia, Danny, E-mail: dmarf8@hawaii.edu [Department of Physics & Astronomy, University of Hawaii, Honolulu, HI 96822 (United States); Nayak, Alekha C., E-mail: acnayak@iitk.ac.in [Department of Physics, Indian Institute of Technology, Kanpur 208016 (India); Tomar, Gaurav, E-mail: tomar@prl.res.in [Physical Research Laboratory, Ahmedabad 380009 (India)

    2017-03-10

    We consider scenarios in which the annihilation of self-conjugate spin-1 dark matter to a Standard Model fermion–antifermion final state is chirality suppressed, but where this suppression can be lifted by the emission of an additional photon via internal bremsstrahlung. We find that this scenario can only arise if the initial dark matter state is polarized, which can occur in the context of self-interacting dark matter. In particular, this is possible if the dark matter pair forms a bound state that decays to its ground state before the constituents annihilate. We show that the shape of the resulting photon spectrum is the same as for self-conjugate spin-0 and spin-1/2 dark matter, but the normalization is less heavily suppressed in the limit of heavy mediators.

  15. Multimode approximation for {sup 238}U photofission at intermediate energies

    Energy Technology Data Exchange (ETDEWEB)

    Demekhina, N. A., E-mail: demekhina@lnr.jinr.ru [Yerevan Physics Institute (Armenia); Karapetyan, G. S. [Yerevan State University (Armenia)

    2008-01-15

    The yields of products originating from {sup 238}U photofission are measured at the bremsstrahlung endpoint energies of 50 and 3500 MeV. Charge and mass distributions of fission fragments are obtained. Symmetric and asymmetric channels in {sup 238}U photofission are singled out on the basis of the model of multimode fission. This decomposition makes it possible to estimate the contributions of various fission components and to calculate the fissilities of {sup 238}U in the photon-energy regions under study.

  16. Effective source size, yield and beam profile from multi-layered bremsstrahlung targets

    International Nuclear Information System (INIS)

    Svensson, R.; Brahme, A.

    1996-01-01

    Modern conformal radiotherapy benefits from heterogeneous dose delivery using scanned narrow bremsstrahlung beams of high energy in combination with dynamic double focused multi-leaf collimation and purging magnets. When using a purging magnet to remove electrons and positrons the target space is limited and unorthodox thin multi-layered targets are needed. A computational technique has therefore been developed to determine the forward yield and the angular distributions of the bremsstrahlung beam as well as the size and location of the effective and the virtual photon point source for arbitrary multi-layer bremsstrahlung targets. The Gaussian approximation of the diffusion equation for the electrons has been used and convolved with the bremsstrahlung production process. For electrons with arbitrary emittance impinging on targets of any multi-layer and atomic number combination, the model is well applicable, at least for energies in the range 1-100 MeV. The intrinsic bremsstrahlung photon profile has been determined accurately by deconvolving the electron multiple scattering process from thin experimental beryllium target profiles. For electron pencil beams incident on a target of high density and atomic number such as tungsten, the size of the effective photon source stays at around a tenth of a millimetre. The effective photon source for low-Z materials such as Be, C and Al is located at depths from 3-7 mm in the target, decreasing with increasing atomic number. The effective photon source at off-axis positions then moves out considerably from the central axis, which should be considered when aligning collimators. For high-Z materials such as tungsten, the location of the effective photon source is at a few tenths of a millimetre deep. The virtual photon point source is located only a few tenths of a millimetre upstream of the effective photon source both for high- and low-Z materials. For 50 MeV electrons incident on multi-layered full range targets the radial

  17. Internal bremsstrahlung from 89Sr and 90Sr

    International Nuclear Information System (INIS)

    Sayibaba, T.; Narasimha Murity, K.; Rao, C.R.; Satyaprakash; Gubbi, G.K.

    1987-01-01

    The internal bremsstrahlung (IB) spectra emitted in the beta-decays of 89 Sr and 90 Sr were measured with a HPGe detector and a multichannel analyser along with a standard geometrical set-up. Sufficient care has been taken to avoid spurious effects. After making all the necessary corrections, the experimental results were compared with the corresponding theoretical distributions due to Knipp and Uhlenbeck and Bloch (KUB), Lewis and Ford, Nilsson, and also due to Ford and Martin (detour theory). The total IB yields of intensity and energy from each of the isotopes in the investigated energy regions are also determined and compared with the corresponding theoretical values. The present results of IB from 89 Sr are satisfactorily accounted for by the KUB theory. In the case of 90 Sr the experimental results of IB coincide with the Coulomb-corrected theoretical distibution due to Nilsson in the energy range from 60 keV to 110 keV and Beyond 110 keV, they are found to be in excess over Nilsson's theory as well as the detour theory due to Ford and Martin up to the maximum photon energy studied, namely 350 keV

  18. Calorimetry end-point predictions

    International Nuclear Information System (INIS)

    Fox, M.A.

    1981-01-01

    This paper describes a portion of the work presently in progress at Rocky Flats in the field of calorimetry. In particular, calorimetry end-point predictions are outlined. The problems associated with end-point predictions and the progress made in overcoming these obstacles are discussed. The two major problems, noise and an accurate description of the heat function, are dealt with to obtain the most accurate results. Data are taken from an actual calorimeter and are processed by means of three different noise reduction techniques. The processed data are then utilized by one to four algorithms, depending on the accuracy desired to determined the end-point

  19. The effect of correction factors on internal bremsstrahlung spectrum

    International Nuclear Information System (INIS)

    Elias, M.M.

    1985-01-01

    Correction factors affecting the experimental spectrum of internal bremsstrahlung (IB) accompanying B-decay have been studied. A wide survey of previous experimental studies, show a discrepancy between experimental results and the available theories of IB production especially for heavy nuclides and forbidden B-transitions, with some agreement in bounded regions in IB spectrum. This is due to the uncertainity in evaluating correction factors and neglecting others. The experimental distributions of IB from 147 Pm, 204 Tl and 90 Y are measured by using two different crystals of NaI(Tl) scintillators (2''x2'' and 3'''x3'') with suitable geometrical arrangements designed to minimize the effect of several factors. The present study covers overlapped ranges of energy from 0.05 to 2.2 MeV to observe the effect of these factors along this wide region of energy. The experimental probabilities are compared with theories. It agrees fairly well with Lewis and Ford theory in case of 14 '7Pm, 204 Tl, and with detour transitions theory in the intermediate region of energies of IB spectrum from 90 Y. Deviation of our results from theories is less than all previous experimental work. 20 tabs.; 43 figs.; 84 refs.; 5 apps

  20. A collimator optimization method for quantitative imaging: application to Y-90 bremsstrahlung SPECT.

    Science.gov (United States)

    Rong, Xing; Frey, Eric C

    2013-08-01

    Post-therapy quantitative 90Y bremsstrahlung single photon emission computed tomography (SPECT) has shown great potential to provide reliable activity estimates, which are essential for dose verification. Typically 90Y imaging is performed with high- or medium-energy collimators. However, the energy spectrum of 90Y bremsstrahlung photons is substantially different than typical for these collimators. In addition, dosimetry requires quantitative images, and collimators are not typically optimized for such tasks. Optimizing a collimator for 90Y imaging is both novel and potentially important. Conventional optimization methods are not appropriate for 90Y bremsstrahlung photons, which have a continuous and broad energy distribution. In this work, the authors developed a parallel-hole collimator optimization method for quantitative tasks that is particularly applicable to radionuclides with complex emission energy spectra. The authors applied the proposed method to develop an optimal collimator for quantitative 90Y bremsstrahlung SPECT in the context of microsphere radioembolization. To account for the effects of the collimator on both the bias and the variance of the activity estimates, the authors used the root mean squared error (RMSE) of the volume of interest activity estimates as the figure of merit (FOM). In the FOM, the bias due to the null space of the image formation process was taken in account. The RMSE was weighted by the inverse mass to reflect the application to dosimetry; for a different application, more relevant weighting could easily be adopted. The authors proposed a parameterization for the collimator that facilitates the incorporation of the important factors (geometric sensitivity, geometric resolution, and septal penetration fraction) determining collimator performance, while keeping the number of free parameters describing the collimator small (i.e., two parameters). To make the optimization results for quantitative 90Y bremsstrahlung SPECT more

  1. Bremsstrahlung from Relativistic Heavy Ions in a Fixed Target Experiment at the LHC

    International Nuclear Information System (INIS)

    Mikkelsen, Rune E.; Uggerhøj, Ulrik I.; Sørensen, Allan H.

    2015-01-01

    We calculate the emission of bremsstrahlung from lead and argon ions in ultraperipheral collisions in a fixed target experiment (AFTER) that uses the LHC beams. With nuclear charges of Ze equal to 82e and 18e, respectively, these ions are accelerated to energies of 7 Tev × Z. The bremsstrahlung peaks around ≈100 GeV and the spectrum exposes the nuclear structure of the incoming ion. The peak structure is significantly different from the flat power spectrum pertaining to a point charge. Photons are predominantly emitted within an angle of 1/γ to the direction of ion propagation. Our calculations are based on the Weizsäcker-Williams method of virtual quanta with application of existing experimental data on photonuclear interactions.

  2. Classical and quantum theories of the polarization bremsstrahlung in the local electron density model

    International Nuclear Information System (INIS)

    Astapenko, V.A.; Bureeva, L.A.; Lisitsa, V.S.

    2000-01-01

    Classical and quantum theories of polarization bremsstrahlung in a statistical (Thomas-Fermi) potential of complex atoms and ions are developed. The basic assumptions of the theories correspond to the approximations employed earlier in classical and quantum calculations of ordinary bremsstrahlung in a static potential. This makes it possible to study on a unified basis the contribution of both channels in the radiation taking account of their interference. The classical model makes it possible to obtain simple universal formulas for the spectral characteristics of the radiation. The theory is applied to electrons with moderate energies, which are characteristic for plasma applications, specifically, radiation from electrons on the argon-like ion KII at frequencies close to its ionization potential. The computational results show the importance of taking account of the polarization channel of the radiation for plasma with heavy ions

  3. New microfocus bremsstrahlung source based on betatron B-18 for high-resolution radiography and tomography

    Science.gov (United States)

    Rychkov, M. M.; Kaplin, V. V.; Malikov, E. L.; Smolyanskiy, V. A.; Stepanov, I. B.; Lutsenko, A. S.; Gentsel'man, V.; Vas'kovskiy, I. K.

    2018-01-01

    New microfocus source of hard bremsstrahlung (photon energy > 1 MeV), based on the betatron B-18 with a narrow Ta target inside, for high-resolution radiography and tomography is presented. The first studies of the source demonstrate its possibilities for practical applications to detect the microdefects in products made from heavy materials and to control gaps in joints of parts of composite structures of engineering facilities. The radiography method was used to investigate a compound object consisting of four vertically arranged steel bars between which surfaces were exposed gaps of 10 μm in width. The radiographic image of the object, obtained with a magnification of 2.4, illustrates the good sensitivity of detecting the gaps between adjacent bars, due to the small width of the linear focus of the bremsstrahlung source.

  4. Stabilization effect of Weibel modes due to inverse bremsstrahlung ...

    Indian Academy of Sciences (India)

    2016-11-04

    Nov 4, 2016 ... In this work, the Weibel instability due to inverse bremsstrahlung absorption in laser fusion plasma ... pling of self-generated magnetic field with the laser wave field. This is ... To describe fully ionized plasma where the interac-.

  5. Dynamic bremsstrahlung from relativistic particles scattered by atom

    International Nuclear Information System (INIS)

    Astapenko, V.A.; Bujmistrov, V.M.; Krotov, Yu.A.; Mikhajlov, L.K.; Trakhtenberg, L.I.

    1985-01-01

    The bremsstrahlung cross section for a relativistic particle scattered by an atom is calculated. In contrast to the screening approximation usually employed, the influence of the atomic electron on the bremsstrahlung is taken into account exactly, viz., the atomic electron is considered as a moving particle interacting with the electromagnetic field and not only as the source of a static external field. Consequently, along with the static term which leads to the Bethe-Heitw,ler formula, a ne dynamic, term appears in the transition amplitude. The corresponding cross section, the dynamic bremsstrahlung cross section, in certain frequensy ranges and certain ranges of the directions of photon emission exceeds considerably the static bremsstrahlung cross section

  6. Measurement of the bremsstrahlung spectra generated from thick ...

    Indian Academy of Sciences (India)

    with those predicted by Monte-Carlo (MC) calculations using PENELOPE code. A close ... done on bremsstrahlung cross-section measurements and many theories have been given for ..... This probability is expected to be maximum for elastic.

  7. A Single Bremsstrahlung Monitor to Measure Luminosity at LEP

    CERN Multimedia

    2002-01-01

    The luminosity, the beam divergence and the longitudinal polarization can be measured at an interaction point of LEP by dectecting the energy, the angular distribution and the circular polarization of the single bremsstrahlung photons (SB) emitted at very forward angle. The luminosity can be measured by this met than by the conventional method of detecting small angle Bhabha scattering. The bunch to bunch relative luminosity can be monitored at a few per mil level in few minutes. Absolute values of the luminosity and of the polarization can be measured with a precision of the order of 1\\%. \\\\ \\\\ The apparatus to detect SB photons consists of a low Z absorber and of an EM calorimeter made of lead and scintillating fibres. Both the total energy and the space distribution of the SB photons are measured. This apparatus has been designed and built at the Department of Physics and INFN Section of the University of Rome ``La Sapienza''. Later on, together with suitable monocrystal converters, it may be used also for...

  8. Internal bremsstrahlung spectral shapes of 45Ca and 35S

    International Nuclear Information System (INIS)

    Babu, R.P.; Murty, K.N.; Murty, V.A.N.

    1976-01-01

    The internal bremsstrahlung spectra emitted in the beta decays of 45 Ca and 35 S were measured using a multichannel NaI(Tl) scintillation spectrometer with a standard geometrical arrangement. After making all the necessary corrections, the experimental results were compared with the allowed theory of Knipp and Uhlenbeck (Physica; 3:425 (1936)) and of Bloch (Phys. Rev.; 50:272 (1936)) (KUB theory) and also with the Coulomb-corrected theories of Lewis and Ford (Phys. Rev.; 107:756 (1957)) and of Nilsson (Ark. Fys.; 10:467 (1956)). In the case of 45 Ca, fairly good agreement with KUB theory was obtained from 30 to 155 keV and above 155 keV the experimental results were in agreement with the Lewis and Ford theory up to 210 keV, the maximum limit of the photon energy investigated. For 35 S, the experimental results are in quite good agreement with KUB theory from 25 to 45 keV, but beyond 45 keV the values are greater than the Coulomb-corrected theories due to both Lewis and Ford and to Nilsson, the experimental excess over Nilsson Coulomb-corrected theory being by factors of 1.07, 1.12 and 1.63 at energies 60, 90 and 110 keV respectively. (author)

  9. Application of split field technique with 42 MeV betatron bremsstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Spurny, V; Caha, A; Krystof, V; Ott, O [Vyzkumny Ustav Klinicke a Experimentalni Onkologie, Brno (Czechoslovakia)

    1977-03-01

    The split field technique of external irradiation in oncology is described. A 120x28x79 mm lead shielding block was manufactured for a bremsstrahlung radiation with 42 MeV maximum energy. The block was secured to a holder whose design corresponded to tube holders. The block shielding capacity was tested by phantom measurements at a focal depth of 130 mm and at a distance of the block from the phantom surface of 990 mm. For the 42 MeV bremsstrahlung the reduction was found to be 15% of the focal dose in the 20x20 cm/sup 2/ field in the focal depth at a distance of 1200 mm from the bremsstrahlung focus. Dose distribution was established by using two opposite fields in combination as well as by the courses of the maximum and the relative doses in variation with the female patient's antero-posterior diameter. The results show that the split field technique permits a short adjustment time, is simple and reproducible. As against cobalt application, the beam characteristics permit reducing the integral dose.

  10. Rare gas isotope yields in bremsstrahlung-induced nuclear reactions of 41K, 87Rb, 127I, 133Cs, and 139La

    International Nuclear Information System (INIS)

    Oura, Y.; Yazawa, A.; Sarkar, S.R.; Sakamoto, K.; Shibata, S.; Fujiwara, I.; Furukawa, M.

    1994-05-01

    Radiochemical yield measurements have been reported for 41 K(γ, π + ) 41 Ar, 87 Rb(γ, π + ) 87 Kr, 133 Cs(γ, π + ) 133m,133g Xe, 127 I(γ, π - xn) 127-x Xe (x=0,2,4,5, and 6), 133 Cs(γ, pxn) 132-x Xe (x=1,3,5,7,9,10, and 11), and 139 La(γ, 3pxn) 136- xXe (x=7,9,11,13,14, and 15) at bremsstrahlung end-point energies(E 0 ) of 50-1200 MeV. For photopion reactions it has been confirmed that the both yields of (γ, π - ) and (γ, π + ) reactions are independent of target mass (A t ) and the yield ratios of (γ, π - ) to (γ, π + ) reactions are about 5 over the studied ranges of E 0 and A t . The profile of 127 I(γ, π - xn) yields as a function of x is similar to that of 133 Cs but quite different from that of 51 V when compared at the same E 0 , suggesting a strong A t dependence. It is also found that the photospallogenic Xe isotope yields from 133 Cs and 139 La are consistent with the reported mass yield pattems of the other radionuclides produced from the same targets. These results are discussed by referring to the previous literature values and to a cascade-evaporation calculation based on the PICA code by Gabriel and Alsmiller. (author)

  11. Bremsstrahlung background and quantitation of thin biological samples

    International Nuclear Information System (INIS)

    Khan, K.M.

    1991-02-01

    An inherent feature of all electron-excited X-ray spectra is the presence of a background upon which the characteristic peaks of interest are superimposed. To extract the x-ray intensity of the characteristics lines of interest, it is necessary to subtract this background, which may be due to both specimen generated Bremsstrahlung and extraneous sources, from a measured x-ray spectrum. Some conventional methods of background subtraction will be briefly reviewed. It has been seen that these conventional methods do not give sufficiently accurate results in biological analysis where the peaks of interest are not well-separated and most of the peaks lie in the region where the background is appreciably curved. An alternative approach of background subtraction for such samples is investigated which involves modelling the background using the currently available knowledge of x-ray physics and energy dispersive detectors. This method is particularly suitable for biological samples as well as other samples having an organic matrix. 6 figs. (author)

  12. Electron accelerator-based production of molybdenum-99: Bremsstrahlung and photoneutron generation from molybdenum vs. tungsten

    Energy Technology Data Exchange (ETDEWEB)

    Tsechanski, A. [Ben-Gurion University of the Negev, Department of Nuclear Engineering, P.O. Box 653, Beer-Sheva 84105 (Israel); Bielajew, A.F. [Department of Nuclear Engineering and Radiological Sciences, The University of Michigan, 2355 Bonisteel Boulevard, Ann Arbor, MI 48109 (United States); Archambault, J.P.; Mainegra-Hing, E. [National Research Council of Canada, Ionizing Radiation Standards Laboratory, Ottawa, ON K1A 0R6 (Canada)

    2016-01-01

    A new “one-stage” approach for production of {sup 99}Mo and other radioisotopes by means of an electron linear accelerator is described. It is based on using a molybdenum target both as a bremsstrahlung converter and as a radioisotope producing target for the production of {sup 99}Mo via the photoneutron reaction {sup 100}Mo(γ,n){sup 99}Mo. Bremsstrahlung characteristics, such as bremsstrahlung efficiency, angular distribution, and energy deposition for molybdenum targets were obtained by means of the EGSnrc Monte Carlo simulation code system. As a result of our simulations, it is concluded that a 60 MeV electron beam incident on a thick Mo target will have greater bremsstrahlung efficiency than the same thickness (in units of r{sub 0}) W target, for target thickness z > 1.84r{sub 0}, where r{sub 0} is the electron range. A 50 MeV electron beam incident on a Mo target will result in greater bremsstrahlung efficiency than the same thickness W target (in units of r{sub 0}) for target thickness case: z ⩾ 2.0r{sub 0}. It is shown for the one-stage approach with thicknesses of (1.84–2.0)r{sub 0}, that the {sup 99}Mo-production bremsstrahlung efficiency of a molybdenum target is greater by ∼100% at 30 MeV and by ∼70% at 60 MeV compared to the values for tungsten of the same thickness (in units of the appropriate r{sub 0}) in the traditional two-stage approach (W converter and separate {sup 99}Mo producing target). This advantage of the one-stage approach arises from the fact that the bremsstrahlung produced is attenuated only once from attenuation in the molybdenum converter/target. In the traditional, two-stage approach, the bremsstrahlung generated in the W-converter/target is attenuated both in the converter in the {sup 99}Mo-producing molybdenum target. The photoneutron production yield of molybdenum and tantalum (as a substitute for tungsten) target was calculated by means of the MCNP5 transport code. On the basis of these data, the specific activity

  13. Studies of plasma breakdown and electron heating on a 14 GHz ECR ion source through measurement of plasma bremsstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Ropponen, T; Machicoane, G; Leitner, D [National Superconducting Cyclotron Laboratory, MSU, East Lansing, MI 48824 (United States); Tarvainen, O; Toivanen, V; Koivisto, H; Kalvas, T; Peura, P; Jones, P [University of Jyvaeskylae, Department of Physics, PO Box 35 (YFL), 40500 Jyvaeskylae (Finland); Izotov, I; Skalyga, V; Zorin, V [Institute of Applied Physics, RAS, 46 Ulyanov St., 603950 Nizhny Novgorod (Russian Federation); Noland, J, E-mail: tommi.ropponen@gmail.com, E-mail: olli.tarvainen@jyu.fi [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States)

    2011-10-15

    Temporal evolution of plasma bremsstrahlung emitted by a 14 GHz electron cyclotron resonance ion source (ECRIS) operated in pulsed mode is presented in the energy range 1.5-400 keV with 100 {mu}s resolution. Such a high temporal resolution together with this energy range has never been measured before with an ECRIS. Data are presented as a function of microwave power, neutral gas pressure, magnetic field configuration and seed electron density. The saturation time of the bremsstrahlung count rate is almost independent of the photon energy up to 100 keV and exhibits similar characteristics with the neutral gas balance. The average photon energy during the plasma breakdown is significantly higher than that during the steady state and depends strongly on the density of seed electrons. The results are consistent with a theoretical model describing the evolution of the electron energy distribution function during the preglow transient.

  14. Endpoints in pediatric pain studies

    NARCIS (Netherlands)

    M. van Dijk (Monique); I. Ceelie (Ilse); D. Tibboel (Dick)

    2011-01-01

    textabstractAssessing pain intensity in (preverbal) children is more difficult than in adults. Tools to measure pain are being used as primary endpoints [e.g., pain intensity, time to first (rescue) analgesia, total analgesic consumption, adverse effects, and long-term effects] in studies on the

  15. Modeling Relativistic Electron Precipitation Bremsstrahlung X-Ray Intensities at 10-100 km Manned Vehicle Altitudes

    Science.gov (United States)

    Krause, L. Habsh; Gilchrist, B. E.; Nishikawa, Ken-Ichi

    2013-01-01

    Relativisitic electron precipitation (REP) events occur when beams or bunches of relativistic electrons of magnetospheric origin enter the Earth's atmosphere, typically at auroral latitudes. REP events are associated with a variety of space weather effects, including production of transitional and bremsstrahlung radiation, catalytic depletion of stratospheric ozone, and scintillation of transionospheric radio waves. This study examines the intensities of x-rays produced at airliner, manned balloon, and space reuseable launch vehicles (sRLVs). The monoenergetic beam is modeled in cylindrical symetry using the paraxial ray equation. Bremsstrahlung photon production is calculated using the traditional Sauter-Elwert cross-section, providing x-ray emission spectra differential in energy and angle. Attenuation is computed for a plane-stratified standard atmosphere, and the loss processes include photoionization, Rayleigh and Compton scattering, electron-positron pair production, and photonuclear interaction. Peak altitudes of electron energy deposition and bremsstrahlung x-ray production were calculated for beams of energies from 1 MeV through 100 MeV. The altitude peak of bremsstrahlung deposition was consistently and significantly lower that that of the electron deposition due to the longer mean free paths of x-rays compared to electrons within the atmosphere. For example, for a nadir-directed monoenergetic 5 MeV beam, the peak deposition altitude was calculated to be 42 km, but the resulting bremsstrahlung deposition peaked at 25 km. This has implications for crew and passenger safety, especially with the growth of the space tourism industry. A survey of results covering the 1-100 MeV spectrum for the three altitude ranges of interest will be presented.

  16. Operation of LIA-30 linear induction accelerator in the mode of generation of two bremsstrahlung pulses

    Energy Technology Data Exchange (ETDEWEB)

    Bossamykin, V S; Gerasimov, A I; Gordeev, V S; Grishin, A V; Gritsina, V P; Tarasov, A D; Fedotkin, A S; Lazarev, S A; Averchenkov, A Ya [All-Russian Scientific Research Institute of Experimental Physics, Sarov (Russian Federation)

    1997-12-31

    The operating mode was studied of the LIA-30 linear induction accelerator ({approx} 40 MeV, {approx} 100 kA, {approx} 30 ns) with the generation of two bremsstrahlung pulses separated by a specified time interval from 0 to 5 {mu}s. In the accelerating channel an additional tube cathode was installed, and a synchronization system for two accelerating module groups triggering the formation and acceleration, at different initial times, of two annular electron beams with different outer diameters was changed. The energy limit of each beam electron acceleration can be controlled, and the energy sum limit is {<=} 540 MeV. (author). 2 tabs., 2 figs.

  17. Study of bremsstrahlung photons in bulk target using MCNP code

    Directory of Open Access Journals (Sweden)

    S. Sangaroon

    2017-11-01

    Full Text Available The aim of this research was to study the feasibility of bremsstrahlung photon production in target bombarded by 1 GeV electrons. The calculations were performed by the Monte Carlo code MCNP. Six target materials with densities between 2 and 20 g/cm3 were studied. The bremsstrahlung photon flux is high for the target density above 8 g/cm3. Copper is the best target for 1 GeV electron beam due to high bremsstrahlung photon production, low scattering and low transmission electron flux. The copper target was altered to have different thicknesses between 0.01 and 2.5 cm. The results showed that the bremsstrahlung photon flux significantly increased when the target thickness increased from 0.01 to 1.5 cm. The angular distribution of the bremsstrahlung photons with angles between 0 and 120 degrees was determined for copper target. The maximum angle of the photon scattering was about 20 degree.

  18. Possibilities for a neutron-proton bremsstrahlung experiment at WNR/LAMPF

    International Nuclear Information System (INIS)

    Wender, S.A.; Nelson, R.O.; Laymon, C.M.; Schillaci, M.; Gibson, B.F.

    1990-01-01

    The high energy and high intensity of the continuous energy (white) neutron source at the WNR target area of the Los Alamos Meson Physics Facility (LAMPF) may make possible a direct measurement of the neutron-proton bremsstrahlung (NPB) cross section. Several recent papers have discussed the operation of the WNR white neutron source in detail so we will just include a short description of the relevant properties of the source in this article. Next the authors will describe one possible method of measuring the NPB cross section which is based on two calorimetric detectors that measure the energies of the scattered neutrons and the recoil protons. Although there are many other possible experimental approaches and geometries, such as measuring the bremsstrahlung gamma ray directly with a multi-element possibilities in this paper. There are several advantages in using a white neutron source for this type of measurement. First, a wide range of incident neutron energies may be covered. In the case of the WNR, the energy range is from below 50 MeV to over 400 MeV which is above the pion production threshold. Second, all incident neutron energies are measure simultaneously. 6 refs., 5 figs

  19. Suppression of bremsstrahlung and pair production due to environmental factors

    International Nuclear Information System (INIS)

    Klein, Spencer

    1999-01-01

    The environment in which bremsstrahlung and pair creation occurs can strongly affect cross sections for these processes. Because ultrarelativistic electromagnetic interactions involve very small longitudinal momentum transfers, the reactions occur gradually, spread over long distances. During this time, even relatively weak factors can accumulate enough to disrupt the interaction. In the Landau-Pomeranchuk-Migdal effect, multiple scattering reduces the bremsstrahlung and pair production cross section. This review will discuss this and a variety of other factors that can suppress bremsstrahlung and pair production, as well as related effects involving beamstrahlung and QCD processes. After surveying different theoretical approaches, experimental measurements will be covered. Recent accurate measurements by the SLAC E-146 Collaboration will be highlighted, along with several recent theoretical works relating to the experiment. (c) 1999 The American Physical Society

  20. Zeff from spectroscopic bremsstrahlung measurements at ASDEX Upgrade and JET

    International Nuclear Information System (INIS)

    Meister, H.; Fischer, R.; Horton, L.D.; Maggi, C.F.; Nishijima, D.; Giroud, C.; Zastrow, K.-D.; Zaniol, B.

    2004-01-01

    The effective ionic charge Z eff is a means to assess the impurity content of a fusion plasma. It can be derived from measurements of bremsstrahlung intensity. These have been extended at ASDEX Upgrade by the usage of the sight lines for the charge exchange recombination diagnostic. Together with a previously installed sight line array, it is now possible to routinely determine the bremsstrahlung intensity over the whole minor radius purely from spectroscopic measurements. In a tokamak where the plasma facing components are made up of various materials, this is necessary to check if measurements are contaminated by line radiation. The bremsstrahlung background of the respective spectra is determined using Bayesian probability theory, giving consistent and improved error statistics. Using the information for electron temperature and density profiles, the Z eff profile is determined by an integrated method. The same approach to assess the Z eff profile has been demonstrated to be successful also at the JET tokamak

  1. Zadig: latest improvements to Bremsstrahlung treatment and in-flight annihilation scheme; Zadig: amelioration du traitement Bremsstrahlung et traitement de l'annihilation en vol

    Energy Technology Data Exchange (ETDEWEB)

    Menard, St

    2006-07-01

    Multigroup cross-section for the 3-dimensional Monte-Carlo transport code DIANE are produced by the ZADIG code. Although DIANE does not transport the electrons and positrons, the production of Bremsstrahlung photons induced by the electrons and positrons during their slowing down is taken into account in the ZADIG code because the electron-gamma cascade is an important process in high energy gamma ray transport. ZADIG does not distinguish positrons from electrons except for the positron annihilation. However, the user can turn on this direction. This report presents the latest improvements to the Bremsstrahlung model of ZADIG and to the positron annihilation algorithm implemented in the code. Positrons can annihilate either in flight or at rest in the latest release of ZADIG. As MCNP does not take into account the annihilation in flight, results of ZADIG-DIANE calculations are compared to the results of GEANT-4 in order to validate the annihilation scheme of ZADIG. The results with annihilation divided by the results without present similar trends between 0.6 and 10 MeV for the 2 codes (GEANT-4 and ZADIG-DIANE), in other words an influence of 5%, so the annihilation scheme programmed in ZADIG appears to be satisfying and can be considered as validated.

  2. Relativistic electron acceleration by net inverse bremsstrahlung in a laser-irradiated plasma

    International Nuclear Information System (INIS)

    Kim, S.H.; Chen, K.W.

    1985-01-01

    Using the quantum-kinetic method, the net acceleration of relativistic electrons in a laser-irradiated plasma is studied as a function of the relevant parameters of the incident laser wave and the plasma wave. It is suggested that, in general, the net acceleration in laser-produced turbulent plasmas is primarily due to inverse bremsstrahlung proceses, and the acceleration gradient exceeds several hundreds gigavolt per meter when the electron energy is large (TeV) and the momentum spread of the beam is properly controlled

  3. Monte Carlo 20 and 45 MeV Bremsstrahlung and dose-reduction calculations

    Energy Technology Data Exchange (ETDEWEB)

    Goosman, D.R.

    1984-08-14

    The SANDYL electron-photon coupled Monte Carlo code has been compared with previously published experimental bremsstrahlung data at 20.9 MeV electron energy. The code was then used to calculate forward-directed spectra, angular distributions and dose-reduction factors for three practical configurations. These are: 20 MeV electrons incident on 1 mm of W + 59 mm of Be, 45 MeV electrons of 1 mm of W and 45 MeV electrons on 1 mm of W + 147 mm of Be. The application of these results to flash radiography is discussed. 7 references, 12 figures, 1 table.

  4. Monte Carlo 20 and 45 MeV Bremsstrahlung and dose-reduction calculations

    International Nuclear Information System (INIS)

    Goosman, D.R.

    1984-01-01

    The SANDYL electron-photon coupled Monte Carlo code has been compared with previously published experimental bremsstrahlung data at 20.9 MeV electron energy. The code was then used to calculate forward-directed spectra, angular distributions and dose-reduction factors for three practical configurations. These are: 20 MeV electrons incident on 1 mm of W + 59 mm of Be, 45 MeV electrons of 1 mm of W and 45 MeV electrons on 1 mm of W + 147 mm of Be. The application of these results to flash radiography is discussed. 7 references, 12 figures, 1 table

  5. Fast measurement of luminosity at LEP by detecting the single bremsstrahlung photons

    International Nuclear Information System (INIS)

    Bini, C.; De Zorzi, G.; Diambrini Palazzi, G.; Di Cosimo, G.; Di Domenico, A.; Gauzzi, P.; Zanello, D.

    1991-01-01

    Luminosity and beam angular divergence have been measured at LEP with a fast monitor based on the single bremsstrahlung process e + e - → e + e - γ. The photons emitted at the interaction point 1 are detected by an electromagnetic calorimeter: both the photon energy and the impact point are measured. The beam angular divergence and the luminosity are determined in few minutes with a statistical error of 1%. With the present experimental layout the systematic error is of few percent; it would be reduced by performing the measurement on an experimental interaction point. (orig.)

  6. Light meson production and pp-bremsstrahlung at the COSY time-of-flight spectrometer

    International Nuclear Information System (INIS)

    Kuhlmann, E.; Brand, H.; Brand, S.; Cloth, P.; Dahmen, M.; Drueke, V.; Eyrich, W.; Filges, D.; Freiesleben, H.; Fritsche, A.; Kilian, K.; Kirsch, M.; Koch, H.; Kraft, R.A.; Krug, J.; Lange, S.; Machner, H.; Matthaey, H.; Michel, P.; Mirz, R.; Moeller, K.; Morsch, H.P.; Naumann, B.; Naumann, L.; Oelert, W.; Parsch, A.; Paul, N.; Ringe, P.; Roderburg, E.; Roehrich, K.; Roeser, A.; Rogge, M.; Schmidt, G.; Schmidt, M.; Schult, O.; Sefzick, T.; Steinke, M.; Stinzing, F.; Stratmann, R.; Turek, P.; Werding, R.; Wirth, S.

    1993-01-01

    Experiments on light meson production and pp-bremsstrahlung as planned for the initial stage at COSY are discussed. Special emphasis will be placed on near-threshold behaviour where due to kinematics all particles are forced into a rather narrow cone around the beam axis. A specially designed charged particle detector system will be used which not only covers the complete forward hemisphere of 2π in the laboratory system but additionally shows maximum resolution in the extreme forward direction with only moderate cuts in the minimally required energy of all ejectiles. (orig.)

  7. Establishing a group of endpoints to support collective operations without specifying unique identifiers for any endpoints

    Science.gov (United States)

    Archer, Charles J.; Blocksom, Michael A.; Ratterman, Joseph D.; Smith, Brian E.; Xue, Hanghon

    2016-02-02

    A parallel computer executes a number of tasks, each task includes a number of endpoints and the endpoints are configured to support collective operations. In such a parallel computer, establishing a group of endpoints receiving a user specification of a set of endpoints included in a global collection of endpoints, where the user specification defines the set in accordance with a predefined virtual representation of the endpoints, the predefined virtual representation is a data structure setting forth an organization of tasks and endpoints included in the global collection of endpoints and the user specification defines the set of endpoints without a user specification of a particular endpoint; and defining a group of endpoints in dependence upon the predefined virtual representation of the endpoints and the user specification.

  8. Nuclear bremsstrahlung in proton induced reactions at 190 MeV (first experiments at AGOR)

    NARCIS (Netherlands)

    Wilschut, HW

    1998-01-01

    An overview is given of the first experiments with the new KVI cyclotron AGOR. First experiments have focused on nuclear bremsstrahlung in few-and many-body reactions. A classical introduction to nuclear bremsstrahlung is given. First results on coherent bremsstrahlung are discussed.

  9. Comparison of Techniques to Reduce Bremsstrahlung Background Radiation from Monoenergetic Photon Beams

    International Nuclear Information System (INIS)

    Johnson, M; McNabb, D

    2006-01-01

    An important applied technology is a tunable mono-energetic photon source [1]. These sources are made of relativistic electron accelerators coupled to low-energy lasers, which produce high-energy, mono-energetic-rays. One challenge associated with systems such as this is a continuum of bremsstrahlung background created when an electron beam passes through an aperture of some sort and the electron bunch or its halo impinges on the aperture pictured in figure 1. For instance, in the current T-REX [1] design for the interaction point between the laser- and electron-beam, the electron-beam passes through the center of a mirror used to reflect the laser. There is a potential with this design that bremsstrahlung radiation may be produced at the edges of the mirror openings and contaminate the mono-energetic photon beam. Certain applications [2] may be sensitive to this contamination. To reduce the bremsstrahlung contaminate a collimator (thickness ∼24in. (calculated from XCOM database [3]) to attenuate by a factor of 10 -3 the 112MeV photons expected in the T-REX demonstration [1]) is situated between the aperture and target. To maximize the brightness of the photon-beam, the collimator opening must be no less than the size of the photon-beam spot size expected to be about 1mm. This fixes the collimator opening. a priori the aperture size must be greater than the collimator opening and is a function distance between the aperture and collimator. In this paper we focus on two approaches to estimate the aperture size, given a collimator and a target whose sizes and distances from the aperture are given. In the next section we will discuss these approaches

  10. The stonehenge technique: a new method of crystal alignment for coherent bremsstrahlung experiments

    Science.gov (United States)

    Livingston, Kenneth

    2005-08-01

    In the coherent bremsstrahlung technique a thin diamond crystal oriented correctly in an electron beam can produce photons with a high degree of linear polarization.1 The crystal is mounted on a goniometer to control its orientation and it is necessary to measure the angular offsets a) between the crystal axes and the goniometer axes and b) between the goniometer and the electron beam axis. A method for measuring these offsets and aligning the crystal was developed by Lohman et al, and has been used successfully in Mainz.2 However, recent attempts to investigate new crystals have shown that this approach has limitations which become more serious at higher beam energies where more accurate setting of the crystal angles, which scale with l/Ebeam, is required. (Eg. the recent installation of coherent bremsstrahlung facility at Jlab, with Ebeam = 6 GeV ) This paper describes a new, more general alignment technique, which overcomes these limitations. The technique is based on scans where the horizontal and vertical rotation axes of the goniometer are adjusted in a series of steps to make the normal to the crystal describe a cone of a given angle. For each step in the scan, the photon energy spectrum is measured using a tagging spectrometer, and the offsets between the electron beam and the crystal lattice are inferred from the resulting 2D plot. Using this method, it is possible to align the crystal with the beam quickly, and hence to set any desired orientation of the crystal relative to the beam. This is essential for any experiment requiring linearly polarized photons produced via coherent bremsstrahlung, and is also required for a systematic study of the channeling radiation produced by the electron beam incident on the crystal.

  11. Proton-proton bremsstrahlung in a relativistic covariant model

    NARCIS (Netherlands)

    Martinus, Gerard Henk

    1998-01-01

    Proton-proton bremsstrahlung is one of the simplest processes involving the half off-shell NN interaction. Since protons are equally-charged particles with the same mass, electric-dipole radiation is suppressed and higher-order effects play an important role. Thus it is possible to get information

  12. Evaluation of electon and nuclear bremsstrahlung in heavy ion collisions

    International Nuclear Information System (INIS)

    Gippner, P.

    1975-01-01

    The detection of quasimolecular X-ray continua provides the possibility of investigating the electron shells of quasimolecules transiently formed during adiabatic heavy ion-atomic collision. The contribution of the electron and nuclear bremsstrahlung to quasimolecular X-ray continua observed in bombarding various targets with 65 and 96 MeV Nb ions were estimated

  13. Infrared phenomena in quantum electrodynamics : II. Bremsstrahlung and compton scattering

    NARCIS (Netherlands)

    Haeringen, W. van

    The infrared aspects of quantum electrodynamics are discussed by treating two examples of scattering processes, bremsstrahlung and Compton scattering. As in the previous paper one uses a non-covariant diagram technique which gives very clear insight in the cancelling of infrared divergences between

  14. Soft-photon analysis of pion-proton bremsstrahlung

    International Nuclear Information System (INIS)

    Liou, M.K.; Nutt, W.T.

    1977-01-01

    We define the soft-photon approximation consistent in its treatment of both the kinematical and dynamical aspects of bremsstrahlung. Using this consistent soft-photon approximation, we calculate π +- p cross sections and obtain excellent agreement with experiment. Our results suggest that the contributions from off-mass-shell effects and resonances are small

  15. NN wave function at small distances and hard bremsstrahlung in the process pp→ppγ

    International Nuclear Information System (INIS)

    Neudatchin, V. G.; Khokhlov, N. A.; Shirokov, A. M.; Knyr, V. A.

    1997-01-01

    Various possibilities of studying the NN wave function at small distances--and in particular, quark degrees of freedom in the NN system--are discussed. It is shown that there is such a possibility at moderate energies--namely, hard bremsstrahlung in the process pp→ppγ at proton-beam energies in the range 350-450 MeV permits distinguishing between the pp wave function with nodes in S and P waves that corresponds to the Moscow potential of NN interaction from functions obtained with repulsive-core mesonic potentials. In the regions where photon energies in the c.m.s. are maximal (forward and backward photon emission angles in the laboratory frame), the pp→ppγ cross section calculated with the Moscow potential has maxima at which it is approximately five times larger than the analogous cross section calculated with repulsive-core mesonic potentials. The coordinate-representation formalism of the theory of bremsstrahlung is expounded

  16. Simulations of bremsstrahlung emission in ultra-intense laser interactions with foil targets

    Science.gov (United States)

    Vyskočil, Jiří; Klimo, Ondřej; Weber, Stefan

    2018-05-01

    Bremsstrahlung emission from interactions of short ultra-intense laser pulses with solid foils is studied using particle-in-cell (PIC) simulations. A module for simulating bremsstrahlung has been implemented in the PIC loop to self-consistently account for the dynamics of the laser–plasma interaction, plasma expansion, and the emission of gamma ray photons. This module made it possible to study emission from thin targets, where refluxing of hot electrons plays an important role. It is shown that the angular distribution of the emitted photons exhibits a four-directional structure with the angle of emission decreasing with the increase of the width of the target. Additionally, a collimated forward flash consisting of high energy photons has been identified in thin targets. The conversion efficiency of the energy of the laser pulse to the energy of the gamma rays rises with both the driving pulse intensity, and the thickness of the target. The amount of gamma rays also increases with the atomic number of the target material, despite a lower absorption of the driving laser pulse. The angular spectrum of the emitted gamma rays is directly related to the increase of hot electron divergence during their refluxing and its measurement can be used in experiments to study this process.

  17. Practice for dosimetry in an X-ray (bremsstrahlung) facility for radiation processing. 2. ed.

    International Nuclear Information System (INIS)

    2002-01-01

    This practice covers dosimetric procedures to be followed in facility characterization, process qualification, and routine processing using X rays (bremsstrahlung) to ensure that the entire product has been treated within an acceptable range of absorbed doses. Other procedures related to facility characterization, process qualification, and routine processing that may influence absorbed dose in the product are also discussed. The establishment of effective or regulatory dose and X-ray energy limits are not within the scope of this practice. In contrast to monoenergetic gamma rays, the bremsstrahlung energy spectrum extends from low values up to the maximum energy of the electrons incident on the X-ray target (see Section 5 and Annex A1). Dosimetry is only one component of a total quality assurance program for an irradiation facility. Other controls besides dosimetry may be required for specific applications such as medical device sterilization and food preservation. For the irradiation of food and the radiation sterilization of health care products, other specific ISO standards exist. For food irradiation, see ISO/ASTM Practice 51431. For the radiation sterilization of health care products, see ISO 11137:1995. In those areas covered by ISO 11137, that standard takes precedence

  18. Dosimetry and microdosimetry using LET spectrometer based on the track-etch detector: radiotherapy bremsstrahlung beam, onboard aircraft radiation field

    Czech Academy of Sciences Publication Activity Database

    Jadrníčková, Iva; Spurný, František

    2006-01-01

    Roč. 41, č. 4 (2006), s. 421-429 ISSN 0033-8451 R&D Projects: GA ČR GA202/04/0795; GA ČR(CZ) GD202/05/H031 Institutional research plan: CEZ:AV0Z10480505 Keywords : linear energy transfer * bremsstrahlung beam * onboard aircraft Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  19. The resonance Bremsstrahlung of a fast charged particle in a medium

    International Nuclear Information System (INIS)

    Beshtoev, Kh.M.

    1998-01-01

    The Bremsstrahlung of the fast charged particle in the medium with dielectric permittivity ε at velocities υ ≥ c/n (n 2 =Reε) is considered. The Bremsstrahlung has singularity at β = 1/ncosθ (β = υ/c, θ is an angle of the Bremsstrahlung). This Bremsstrahlung is interpreted as resonance Bremsstrahlung with the width characterized by Imε=ε 2 , and the less ε 2 is, the higher the peak of this resonance rises. The angular distribution of the Bremsstrahlung is determined by cos θ=1/nβ and this angle coincides with the angle of the Cherenkov radiation. At β=1/n this resonance Bremsstrahlung goes in the forward direction and depends on frequency ω (ε=ε (ω))

  20. Studies on the effect of the axial magnetic field on the x-ray bremsstrahlung in a 2.45 GHz permanent magnet microwave ion source

    International Nuclear Information System (INIS)

    Kumar, Narender; Rodrigues, G.; Lakshmy, P. S.; Mathur, Y.; Ahuja, R.; Kanjilal, D.; Baskaran, R.

    2014-01-01

    A compact microwave ion source has been designed and developed for operation at a frequency of 2.45 GHz. The axial magnetic field is based on two permanent magnet rings, operating in the “off-resonance” mode and is tunable by moving the permanent magnets. In order to understand the electron energy distribution function, x-ray bremsstrahlung has been measured in the axial direction. Simulation studies on the x-ray bremsstrahlung have been carried out to compare with the experimental results. The effect of the axial magnetic field with respect to the microwave launching position and the position of the extraction electrode on the x-ray bremsstrahlung have been studied

  1. Studies on the effect of the axial magnetic field on the x-ray bremsstrahlung in a 2.45 GHz permanent magnet microwave ion source

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Narender; Rodrigues, G., E-mail: gerosro@gmail.com; Lakshmy, P. S.; Mathur, Y.; Ahuja, R.; Kanjilal, D. [Inter University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi (India); Baskaran, R. [Indira Gandhi Centre for Atomic Research, Kalpakkam, Tamilnadu (India)

    2014-02-15

    A compact microwave ion source has been designed and developed for operation at a frequency of 2.45 GHz. The axial magnetic field is based on two permanent magnet rings, operating in the “off-resonance” mode and is tunable by moving the permanent magnets. In order to understand the electron energy distribution function, x-ray bremsstrahlung has been measured in the axial direction. Simulation studies on the x-ray bremsstrahlung have been carried out to compare with the experimental results. The effect of the axial magnetic field with respect to the microwave launching position and the position of the extraction electrode on the x-ray bremsstrahlung have been studied.

  2. Studies on the effect of the axial magnetic field on the x-ray bremsstrahlung in a 2.45 GHz permanent magnet microwave ion source.

    Science.gov (United States)

    Kumar, Narender; Rodrigues, G; Lakshmy, P S; Baskaran, R; Mathur, Y; Ahuja, R; Kanjilal, D

    2014-02-01

    A compact microwave ion source has been designed and developed for operation at a frequency of 2.45 GHz. The axial magnetic field is based on two permanent magnet rings, operating in the "off-resonance" mode and is tunable by moving the permanent magnets. In order to understand the electron energy distribution function, x-ray bremsstrahlung has been measured in the axial direction. Simulation studies on the x-ray bremsstrahlung have been carried out to compare with the experimental results. The effect of the axial magnetic field with respect to the microwave launching position and the position of the extraction electrode on the x-ray bremsstrahlung have been studied.

  3. Groomed jets in heavy-ion collisions: sensitivity to medium-induced bremsstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Mehtar-Tani, Yacine [Institute of Nuclear Theory, University of Washington,Seattle, WA 98195-1550 (United States); Tywoniuk, Konrad [Theoretical Physics Department, CERN,1211 Geneva 23 (Switzerland)

    2017-04-21

    We argue that contemporary jet substructure techniques might facilitate a more direct measurement of hard medium-induced gluon bremsstrahlung in heavy-ion collisions, and focus specifically on the “soft drop declustering” procedure that singles out the two leading jet substructures. Assuming coherent jet energy loss, we find an enhancement of the distribution of the energy fractions shared by the two substructures at small subjet energy caused by hard medium-induced gluon radiation. Departures from this approximation are discussed, in particular, the effects of colour decoherence and the contamination of the grooming procedure by soft background. Finally, we propose a complementary observable, that is the ratio of the two-pronged probability in Pb-Pb to proton-proton collisions and discuss its sensitivity to various energy loss mechanisms.

  4. Groomed jets in heavy-ion collisions: sensitivity to medium-induced bremsstrahlung

    CERN Document Server

    Mehtar-Tani, Yacine

    2017-04-21

    We argue that contemporary jet substructure techniques might facilitate a more direct measurement of hard medium-induced gluon bremsstrahlung in heavy-ion collisions, and focus specifically on the "soft drop declustering" procedure that singles out the two leading jet substructures. Assuming coherent jet energy loss, we find an enhancement of the distribution of the energy fractions shared by the two substructures at small subjet energy caused by hard medium-induced gluon radiation. Departures from this approximation are discussed, in particular, the effects of colour decoherence and the contamination of the grooming procedure by soft background. Finally, we propose a complementary observable, that is the ratio of the two-pronged probability in Pb-Pb to proton-proton collisions and discuss its sensitivity to various energy loss mechanisms.

  5. Groomed jets in heavy-ion collisions: sensitivity to medium-induced bremsstrahlung

    Science.gov (United States)

    Mehtar-Tani, Yacine; Tywoniuk, Konrad

    2017-04-01

    We argue that contemporary jet substructure techniques might facilitate a more direct measurement of hard medium-induced gluon bremsstrahlung in heavy-ion collisions, and focus specifically on the "soft drop declustering" procedure that singles out the two leading jet substructures. Assuming coherent jet energy loss, we find an enhancement of the distribution of the energy fractions shared by the two substructures at small subjet energy caused by hard medium-induced gluon radiation. Departures from this approximation are discussed, in particular, the effects of colour decoherence and the contamination of the grooming procedure by soft background. Finally, we propose a complementary observable, that is the ratio of the two-pronged probability in Pb-Pb to proton-proton collisions and discuss its sensitivity to various energy loss mechanisms.

  6. Groomed jets in heavy-ion collisions: sensitivity to medium-induced bremsstrahlung

    International Nuclear Information System (INIS)

    Mehtar-Tani, Yacine; Tywoniuk, Konrad

    2017-01-01

    We argue that contemporary jet substructure techniques might facilitate a more direct measurement of hard medium-induced gluon bremsstrahlung in heavy-ion collisions, and focus specifically on the “soft drop declustering” procedure that singles out the two leading jet substructures. Assuming coherent jet energy loss, we find an enhancement of the distribution of the energy fractions shared by the two substructures at small subjet energy caused by hard medium-induced gluon radiation. Departures from this approximation are discussed, in particular, the effects of colour decoherence and the contamination of the grooming procedure by soft background. Finally, we propose a complementary observable, that is the ratio of the two-pronged probability in Pb-Pb to proton-proton collisions and discuss its sensitivity to various energy loss mechanisms.

  7. A study of LPM suppression of bremsstrahlung at 25 GeV

    International Nuclear Information System (INIS)

    Anthony, P.; Becker-Szendy, R.; Bosted, P.

    1993-03-01

    We are making an accurate measurement of the LPM suppression of bremsstrahlung with 25 GeV electrons. By using a 120 pulses per second beam, a precise BGO calorimeter, and spectrometer to tag the outgoing electrons, we are able to make an accurate measurement of the bremsstrahlung photons in the 0-400 MeV region, where the Bethe Heitler and LPM predictions differ. We are taking data with targets made of carbon, uranium, tungsten and iron, with thicknesses in the 2% to 6% X 0 range. In addition, we are taking data with two very thin gold targets. The latter have thicknesses that are comparable to or less than the LPM formation zone length, and so should not exhibit LPM suppression. We are also studying photons of a few MeV in energy, to test the closely related longitudinal density effect predicted by Ter-Mikaelian in which very low energy photon emission is suppressed due to dielectric effects of the medium

  8. Measurement of parity violation in the photodisintegration of deuterium and in the production of Bremsstrahlung on tantalum

    International Nuclear Information System (INIS)

    Earle, E.D.; McDonald, A.B.; Kidner, S.H.; Clifford, E.T.H.; Hill, J.J.; Keech, G.H.; Chupp, T.E.; Schneider, M.B.

    1987-01-01

    The circular polarization dependent component of the total cross section for photodisintegration of deuterium has been measured to be (2.7±2.8) x 10 -6 for Bremsstrahlung with an end point of 4.1 MeV and (7.7±5.3) x 10 -6 for an end point of 3.2 MeV. The helicity dependent component of the total cross section for the production of Bremsstrahlung on tantalum by longitudinally polarized electrons has been measured to be (0.63±0.70) x 10 -6 for an electron energy of 4.1 MeV and (3.1±1.5) x 10 -6 at 3.2 MeV. All measurements are in agreement with theoretical predictions for these processes. (author)

  9. Bremsstrahlung Based Positron Annihilation Spectroscopy for Material Defect Analysis

    International Nuclear Information System (INIS)

    Selim, F.A.; Wells, D.P.; Harmon, F.; Kwofie, J.; Lancaster, G.; Jones, J.L.

    2003-01-01

    The Idaho Accelerator Center (IAC) has developed new techniques for Positron Annihilation Spectroscopy (PAS) using highly penetrating γ-rays to create positrons inside the material via pair production. γ-Ray induced positron annihilation spectroscopy can provide highly penetrating probes for material characterization and defect analysis. Bremsstrahlung beams from small, pulsed electron Linacs (6 MeV) have been used to bombard the materials to generate positrons, which annihilate with the material electrons emitting 511 keV radiation. We have also synchronized bremsstrahlung pulses with laser irradiation pulses to study dynamic structural changes in material. In addition, we have developed another method using (p,γ) reactions from a 2 MeV proton beam, which induce coincident γ-rays to perform positron life-time spectroscopy. We have showed the feasibility of extending PAS into thick samples and a wide variety of materials and industrial applications

  10. Neutral bremsstrahlung radiation of Ne, Ar and O

    International Nuclear Information System (INIS)

    Kung, R.T.V.; Chang, C.H.

    1976-01-01

    The neutral Bremsstrahlung cross-sections of Ne, Ar and atomic oxygen around the 3 and 10μ wavelength regions were measured in a high temperature plasma generated in a shock tube. The results were generally a factor of three higher than the theoretical values calculated by Geltman (Geltman, S., JQSRT vol.13, 601 (1973)). Agreement with the experimental results of Taylor and Caledonia (Taylor, R.L. and Caledonia, G., JQSRT vol.9, 657; 681, 1969) around 3μ was good except for the case of Ne. The cross-sections around 10μ are the first measurements in this wavelength region. Enhanced radiation due to atomic line emission on top of the Bremsstrahlung continuum, as predicted by Hyman (Hyman, H.A. and Von Rosenberg, C.W. Jr., JQSRT, vol.15, 919, 1975) was observed around 7.44μ. (author)

  11. Nuclear effects on bremsstrahlung neutrino rates of astrophysical interest

    International Nuclear Information System (INIS)

    Stoica, Sabin; Horvath, J.E.

    2002-01-01

    We calculate in this work the rates for the neutrino pair production by nucleon-nucleon bremsstrahlung taking into account the full contribution from a nuclear one-pion-exchange potential. It is shown that if the temperatures are low enough (T≤20 MeV), the integration over the nuclear part can be done for the general case, ranging from the completely degenerate (D) to the nondegenerate (ND) regime. We find that the inclusion of the full nuclear contribution enhances the neutrino pair production by nn and pp bremsstrahlung by a factor of about 2 in both the D and ND limits when compared with previous calculations. This result may be relevant for the physical conditions of interest in the semitransparent regions near the neutrinosphere in type II supernovae, cooling of neutron stars, and other astrophysical situations

  12. Bremsstrahlung radiation of a plasma expanding into vacuum

    International Nuclear Information System (INIS)

    Grigor'ev, V.G.; Silakov, V.P.; Fetisov, V.S.

    1978-01-01

    Bremsstrahlung of a flat layer of a dense hot homogeneous plasma expanding to vacuum is considered. The spread of plasma is assumed to be adiabatic, and the plasma density and temperature are considered as known functions of coordinates and time in the radiation transport equation. Formulae for radiation intensity have been obtained in cases when the plasma layer covered by the rarefaction wave are optically thin and optically thick. The dependences of radiation intensity on the parameter α characterizing the optical thickness of the plasma layer and the spectrum of radiation of the spreading layer are presented graphically. It is shown that spread has an essential effect on the heat transfer and the spectral composition of the bremsstrahlung of a dense high-temperature plasma

  13. Diffractive production off nuclei-shadow of hadronic bremsstrahlung

    International Nuclear Information System (INIS)

    Bialas, A.; Czyz, W.

    1974-01-01

    Diffractive production on nuclei is calculated using as an input a specific model for diffractive production on nucleons. In this model diffractive production is described as a shadow of non-diffractive multiple production of particles. The mechanism for non-diffractive production is taken to be hadronic bremsstrahlung of independently produced clusters. It is shown that such a model naturally explains the strikingly simple pattern of absorption observed in coherent production on nuclei. Possible generalizations of these results are indicated. (author)

  14. Simultaneous investigation of parent electrons and bremsstrahlung x rays by rocket-borne detectors

    International Nuclear Information System (INIS)

    Vij, K.K.; Venkatesan, D.; Sheldon, W.R.; Kern, J.W.; Benbrook, J.R.; Whalen, B.A.

    1975-01-01

    Simultaneous measurements of the energy spectrum of precipitating electrons and the resulting bremsstrahlung X ray spectrum were carried out during an auroral event on March 3, 1971, at the Churchill Research Range, Manitoba, Canada. The electron data were obtained with detectors on a Black Brant VB sounding rocket (275-km apogee), while the X ray flux was measured by an instrument package that was boosted to 60 km on an Arcas rocket. The X ray package was deployed on a parachute at apogee to provide a slow descent through the atmosphere. Thick target bremsstrahlung theory is used to calculate the X ray flux produced by the incident electrons, and a Monte Carlo method is used to predict the X ray spectrum at various altitudes appropriate for comparison with the measured X ray data. Satisfactory agreement between theory and experiment is obtained, and the value of the constant in the thick target theory has been estimated to be (2plus-or-minus0.5) times10 -5

  15. Simultaneous investigation of parent electrons and bremsstrahlung x rays by Rocket--Borne detectors

    International Nuclear Information System (INIS)

    Vij, K.K.; Venkatesan, D.; Sheldon, W.R.; Kern, J.W.; Benbrook, J.R.; Whalen, B.A.

    1975-01-01

    Simultaneous measurements of the energy spectrum of precipitating electrons and the resulting bremsstrahlung X ray spectrum were carried out during an auroral event on March 3, 1971, at the Churchill Research Range, Manitoba, Canada. The electron data were obtained with detectors on a Black Brant VB sounding rocket (275-km apogee), while the X ray flux was measured by an instrument package that was boosted to 60 km on an Arcas rocket. The X ray package was deployed on a parachute apogee to provide a slow descent through the atmosphere. Thick target bremsstrahlung theory is used to calculate the X ray flux produced by the incident electrons, and a Monte Carlo method is used to predict the X ray spectrum at various altitudes appropriate for comparison with the measured X ray data. Satisfactory agreement between theory and experiment is obtained, and the value of the constant in the thick target theory has been estimated to be (2plus-or-minus0.5) times10 -5 . (auth)

  16. Decay energy of Fe from its inner Bremsstrahlung spectrum

    Indian Academy of Sciences (India)

    Fe decays by electron capture process with a half-life of 2.7 years. ... The 'source' was tested for the presence of ¬ impurities using a beta ray spectrometer and found to be ... age of 30 experiments is termed as mean source plus background.

  17. SU-E-E-08: Applications of the Quantization of Coupled Circuits in Radiation Physics (design of Klystron, Bremsstrahlung, Synchrotron)

    Energy Technology Data Exchange (ETDEWEB)

    Ulmer, W

    2015-06-15

    Purpose: During the past decade the quantization of coupled/forced electromagnetic circuits with or without Ohm’s resistance has gained the subject of some fundamental studies, since even problems of quantum electrodynamics can be solved in an elegant manner, e.g. the creation of quantized electromagnetic fields. In this communication, we shall use these principles to describe optimization procedures in the design of klystrons, synchrotron irradiation and high energy bremsstrahlung. Methods: The base is the Hamiltonian of an electromagnetic circuit and the extension to coupled circuits, which allow the study of symmetries and perturbed symmetries in a very apparent way (SU2, SU3, SU4). The introduction resistance and forced oscillators for the emission and absorption in such coupled systems provides characteristic resonance conditions, and atomic orbitals can be described by that. The extension to virtual orbitals leads to creation of bremsstrahlung, if the incident electron (velocity v nearly c) is described by a current, which is associated with its inductivitance and the virtual orbital to the charge distribution (capacitance). Coupled systems with forced oscillators can be used to amplify drastically the resonance frequencies to describe klystrons and synchrotron radiation. Results: The cross-section formula for bremsstrahlung given by the propagator method of Feynman can readily be derived. The design of klystrons and synchrotrons inclusive the radiation outcome can be described and optimized by the determination of the mutual magnetic couplings between the oscillators induced by the currents. Conclusions: The presented methods of quantization of circuits inclusive resistance provide rather a straightforward way to understand complex technical processes such as creation of bremsstrahlung or creation of radiation by klystrons and synchrotrons. They can either be used for optimization procedures and, last but not least, for pedagogical purposes with regard to

  18. Simulations of Beam Optics and Bremsstrahlung for High Intensity and Brightness Channeling Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Hyun, J. [Sokendai, Tsukuba; Piot, P. [NIU, DeKalb; Sen, T. [Fermilab

    2018-04-12

    This paper presents X-ray spectra of channeling radiation expected at the FAST (Fermi Accelerator Science and Technology) facility in Fermilab. Our purpose is to produce high brightness quasi-monochromatic X-rays in an energy range from 40 keV to 110 keV. We will use a diamond crystal and low emittance electrons with an energy of around 43 MeV. The quality of emitted X-rays depends on parameters of the electron beam at the crystal. We present simulations of the beam optics for high brightness and high yield operations for a range of bunch charges. We estimate the X-ray spectra including bremsstrahlung background. We discuss how the electron beam distributions after the diamond crystal are affected by channeling. We discuss an X-ray detector system to avoid pile-up effects during high charge operations.

  19. Impact of bremsstrahlung on the neutrinosphere for muon and tau neutrinos

    Energy Technology Data Exchange (ETDEWEB)

    Yasin, Hannah; Bartl, Alexander [Institut fuer Kernphysik, TU Darmstadt (Germany); Arcones, Almudena [Institut fuer Kernphysik, TU Darmstadt (Germany); GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany)

    2015-07-01

    Core-collapse supernovae present a challenging and exciting problem that strongly depends on all forces (strong, weak, electromagnetism, and gravity). Neutrinos, although weakly interacting, are key to transporting energy and momentum. Therefore, detailed treatment of neutrino reactions is critical to understand these high energy events. We have studied the impact of different neutrino reactions on the position of the neutrinosphere (i.e., region where neutrinos decouple from matter). Since the density in this region is high the effect of nuclear interactions has to be considered for bremsstrahlung: N+N→N+N+ν+ anti ν. We have employed new, improved approaches to calculate the inverse process and show the effect on the position of the neutrinosphere for muon and tau neutrinos.

  20. X-ray generation from Bremsstrahlung effect using stainless steel target

    International Nuclear Information System (INIS)

    Siti Aiasah Hashim; Shari Jahar; Leo Kee Wah; Muhammad Zahidee Taat

    2004-01-01

    X-ray radiation is produced when high energy electron interacts with metals. This process is known as Bremsstrahlung. In commercial electron beam irradiator, this process may be utilized to serve irradiation of thick products with lower dose requirement such disinfestation of fruits, delaying ripening and medical product sterilization. Initial experiment was carried out to measure the amount of x-ray radiation produced by using a simple converter. In this experiment, the target material is the stainless steel beam shutter that is normally used to protect the window. The maximum energy for the Eps 3000 is 3 MeV and was used generate the x-ray radiation. The dose was measure using CTA film and analyzed using UV spectrophotometer. The results obtained showed that sufficient amount of x-ray dose can be generated for low dose irradiation by using this simple set up. (Author)

  1. Further investigating the determination of phosphorus in plants by INAA using bremsstrahlung measurement

    International Nuclear Information System (INIS)

    Matsubara, T.C.M.; Bacchi, M.A.; De Nadai Fernandes, E.A.

    2012-01-01

    Phosphorus is an essential element for plants and animals, playing a fundamental role in the production of biochemical energy. Despite its relevance, phosphorus is not commonly determined by instrumental neutron activation analysis (INAA), because 32 P does not emit gamma-rays in its decay. There are alternative methods for the determination of phosphorus by INAA, such as the use of beta counting or the measurement of bremsstrahlung originated from the high energy beta particle from 32 P. Here the determination of phosphorus in plant materials by measuring the bremsstrahlung production was further investigated, to optimize an analytical protocol for minimizing interferences and overcoming the poor specificity. Eight certified reference materials of plant matrices with phosphorus ranging between 171 and 5,180 mg kg -1 were irradiated at a thermal neutron flux of 9.5 x 10 12 cm -2 s -1 and measured with a HPGe detector at decay times varying from 7 to 60 days. Phosphorus solutions added to a certified reference material at three levels were used for calibration. Counts accumulated in the baseline at four different regions of the gamma-ray spectra were tested for the determination of phosphorus, with better results for the 100 keV region. The Compton scattering contribution in the selected range was discounted using an experimental peak-to-Compton factor and the net areas of all peaks in the spectra with energies higher than 218 keV, i.e. Compton edge above 100 keV. Amongst the interferences investigated, the production of 32 P from sulfur, and the contribution of Compton scattering should be considered for producing good results. (author)

  2. Secondary-electron-bremsstrahlung imaging for proton therapy

    Energy Technology Data Exchange (ETDEWEB)

    Yamaguchi, Mitsutaka; Nagao, Yuto [Takasaki Advanced Radiation Research Institute, Quantum Beam Science Research Directorate, National Institutes for Quantum and Radiological Science and Technology, 1233 Watanuki-Machi, Takasaki, Gunma (Japan); Ando, Koki; Yamamoto, Seiichi [Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-Ku, Nagoya, Aichi (Japan); Toshito, Toshiyuki [Department of Proton Therapy Physics, Nagoya Proton Therapy Center, Nagoya City West Medical Center, 1-1-1 Hirate-cho, Kita-Ku, Nagoya, Aichi (Japan); Kataoka, Jun [Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo (Japan); Kawachi, Naoki [Takasaki Advanced Radiation Research Institute, Quantum Beam Science Research Directorate, National Institutes for Quantum and Radiological Science and Technology, 1233 Watanuki-Machi, Takasaki, Gunma (Japan)

    2016-10-11

    A feasibility study on an imaging technique of a therapeutic proton-beam trajectory using a gamma camera by measuring secondary electron bremsstrahlung (SEB) was performed by means of Monte Carlo simulations and a beam-irradiation experiment. From the simulation and experimental results, it was found that a significant amount of SEB yield exists between the beam-injection surface and the range position along the beam axis and the beam trajectory is clearly imaged by the SEB yield. It is concluded that the SEB imaging is a promising technique for monitoring of therapeutic proton-beam trajectories.

  3. Study of Diffractive Bremsstrahlung at 13 TeV LHC

    CERN Document Server

    Czekierda, Sabina

    2016-01-01

    Feasibility studies of the diffractive bremsstrahlung measurement at the LHC at $\\sqrt s$ = 13 TeV are presented. The method considered for this measurement uses the ATLAS detector and, in particular, the Zero Degree Calorimeter and the ATLAS Forward Proton detectors. The signal and background processes were generated with GenEx and PYTHIA 8.2 generators, respectively. The obtained fiducial cross sections are 1.2 ub for the signal and 6 ub for the background. Further reduction of the background is possible by the optimisation of event selection cuts.

  4. Application of electron and Bremsstrahlung beams for composite materials processing

    International Nuclear Information System (INIS)

    Zalyubovsky, I.I.; Avilov, A.M.; Popov, G.F.; Rudychev, V.G.

    1998-01-01

    In Kharkiv University the radiation process of obtaining composite polymer materials, CPM, with high strength properties and corrosion resistance was studied. CPM are manufactured by vacuum impregnating capillary-porous materials with synthetic monomers and oligomers or by molding granular waste and resins which are further treated by relativistic electron or Bremsstrahlung beam. Such radiation treatment yields new CPM in which capillary-porous structure acting as reinforcement is filled with polymer. The results of the applied research with industrial electron accelerator in the field of thick CPM formation are presented

  5. Electron, electron-bremsstrahlung and proton depth-dose data for space-shielding applications

    Science.gov (United States)

    Seltzer, S. M.

    1979-01-01

    A data set has been developed, consisting of depth-dose distributions for omni-directional electron and proton fluxes incident on aluminum shields. The principal new feature of this work is the accurate treatment, based on detailed Monte Carlo calculations, of the electron-produced bremsstrahlung component. Results covering the energy region of interest in space-shielding calculations have been obtained for the absorbed dose (a) as a function of depth in a semi-infinite medium, (b) at the edge of slab shields, and (c) at the center of a solid sphere. The dose to a thin tissue-equivalent detector was obtained as well as that in aluminum. Various results and comparisons with other work are given.

  6. Calculation of gas Bremsstrahlung power from straight sections of storage ring at SSRF

    International Nuclear Information System (INIS)

    Hua Zhengdong; Xu Xunjiang; Fang Keming; Xu Jiaqiang

    2008-01-01

    The Shanghai Synchrotron Radiation Facility (SSRF) is a third-generation synchrotron radiation light source with 3.5 GeV in energy, which is composed of the linear accelerator, the booster and the storage ring. The storage ring provides 16 standard straight sections of 6.5 m and 4 long straight sections of 12 meters. Gas Bremsstrahlung (GB) produced by the interaction of the stored beam with the residual gas molecules in straight section, which is so intense and has a very small angular that the GB spectra, the GB power and the GB power distribution should be known. The characters of GB are studied by means of Fluka Monte Carlo code. Our result shows agreement with those obtained by the experiential formulae. (authors)

  7. New exclusion limits for dark gauge forces from proton Bremsstrahlung in beam-dump data

    Energy Technology Data Exchange (ETDEWEB)

    Bluemlein, Johannes [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Brunner, Juergen [Aix-Marseille Univ. CNRS/IN2P3 (France). CPPM

    2013-11-15

    We re-analyze published proton beam dump data taken at the U70 accelerator at IHEP Serpukhov with the {nu}-calorimeter I experiment in 1989 to set mass-coupling limits for dark gauge forces. The corresponding data have been used for axion and light Higgs particle searches before. More recently, limits on dark gauge forces have been derived from this data set, considering a dark photon production from {pi}{sup 0}-decay. Here we determine extended mass and coupling exclusion bounds for dark gauge bosons ranging to masses m{sub {gamma}'} of 624 MeV at admixture parameters {epsilon}{approx_equal}10{sup -6} considering high-energy Bremsstrahlung of the U-boson of the initial proton beam and different detection mechanisms.

  8. Effects of fissioning nuclei distributions on fragment mass distributions for high energy fission

    Directory of Open Access Journals (Sweden)

    Rossi P C R

    2012-02-01

    Full Text Available We study the effects of fissioning nuclei mass- and energy-distributions on the formation of fragments for fission induced by high energy probes. A Monte Carlo code called CRISP was used for obtaining mass distributions and spectra of the fissioning nuclei for reactions induced by 660 MeV protons on 241Am and on 239Np, by 500 MeV protons on 208Pb, and by Bremsstrahlung photons with end-point energies at 50 MeV and 3500 MeV on 238U. The results show that even at high excitation energies, asymmetric fission may still contribute significantly to the fission cross section of actinide nuclei, while it is the dominante mode in the case of lead. However, more precise data for high energy fission on actinide are necessary in order to allow definite conclusions.

  9. Spatial distribution of bremsstrahlung in water and water-iron by 22-MeV electron bombardment measured with activation detectors

    International Nuclear Information System (INIS)

    Nakamura, Takashi; Nishimoto, Takanao; Hirayama, Hideo.

    1977-01-01

    The spatial distributions of bremsstrahlung in water (1 m thick) and water (60 cm thick)-iron (6.3 cm thick) bombarded by 22-MeV electrons were measured by using a new activation method which we developed. These informations are useful for studying shielding, residual activity and radiation damage of accelerator and target materials. From the measured activities, the bremsstrahlung spectra in water were evaluated with the LYRA and the SAND-II unfolding codes. The evaluated spectra were in good agreement with the analytical calculation by the DIBRE code, except for the higher energy ends. The longitudinal and the lateral distributions of bremsstrahlung flux in water were obtained by integrating the evaluated spectra above 8 MeV. The agreement of the experimental and the calculated flux distributions was very good except for a large angle to beam direction. The total photon number crossing a plane normal to the beam axis attenuates exponentially along the axial depth. The iso-flux contour of bremsstrahlung flux was given by interpolating the flux distribution curves. Only the saturated activities of gold detectors were obtained for water-iron in good experimental accuracy. The spatial distribution of gold saturated activities in water-iron clearly shows the attenuating effect due to strong absorption in iron. (auth.)

  10. Accuracy evaluation of a Compton X-ray spectrometer with bremsstrahlung X-rays generated by a 6 MeV electron bunch

    Energy Technology Data Exchange (ETDEWEB)

    Kojima, Sadaoki, E-mail: kojima-s@ile.osaka-u.ac.jp; Arikawa, Yasunobu; Zhang, Zhe; Ikenouchi, Takahito; Morace, Alessio; Nagai, Takahiro; Abe, Yuki; Sakata, Shouhei; Inoue, Hiroaki; Utsugi, Masaru; Nakai, Mitsuo; Nishimura, Hiroaki; Shiraga, Hiroyuki; Fujioka, Shinsuke; Azechi, Hiroshi [Institute of Laser Engineering, Osaka University, 2-6 Yamada-oka, Suita, Osaka 565-0871 (Japan); Nishimura, Yasuhiko; Togawa, Hiromi [Toyota Technical Development Corporation, 1-21 Imae, Hanamoto-cho, Toyota, Aichi 470-0334 (Japan); Ozaki, Tetsuo [National Institute for Fusion Science, 322-6 Oroshicho, Toki, Gifu 509-5292 (Japan); Kato, Ryukou [The Institute of Science and Industrial Research, Osaka University, 2-6 Yamada-oka, Suita, Osaka (Japan)

    2014-11-15

    A Compton-scattering-based X-ray spectrometer is developed to obtain the energy distribution of fast electrons produced by intense laser and matter interactions. Bremsstrahlung X-rays generated by fast electrons in a material are used to measure fast electrons’ energy distribution in matter. In the Compton X-ray spectrometer, X-rays are converted into recoil electrons by Compton scattering in a converter made from fused silica glass, and a magnet-based electron energy analyzer is used to measure the energy distribution of the electrons that recoil in the direction of the incident X-rays. The spectrum of the incident X-rays is reconstructed from the energy distribution of the recoil electrons. The accuracy of this spectrometer is evaluated using a quasi-monoenergetic 6 MeV electron bunch that emanates from a linear accelerator. An electron bunch is injected into a 1.5 mm thick tungsten plate to produce bremsstrahlung X-rays. The spectrum of these bremsstrahlung X-rays is obtained in the range from 1 to 9 MeV. The energy of the electrons in the bunch is estimated using a Monte Carlo simulation of particle-matter interactions. The result shows that the spectrometer's energy accuracy is ±0.5 MeV for 6.0 MeV electrons.

  11. Bremsstrahlung spectra for Al, Cs, and Au atoms in high-temperature, high-density plasmas

    International Nuclear Information System (INIS)

    Kim, L.; Pratt, R.H.; Tseng, H.K.

    1985-01-01

    Results are presented from a numerical calculation for the bremsstrahlung spectrum and Gaunt factors of Al, Cs, and Au atoms in high-temperature (-T), high-density (-rho) plasmas. Plasma temperatures kT = 0.1 and 1.0 keV and plasma densities rho = rho 0 (the normal solid density) and rho = 100rho 0 are considered. This allows us to determine the generality and identify the origins of features which we had previously identified in calculations for Cs. We also now present results for the total energy loss of an electron in such a plasma. We use a relativistic multipole code which treats the bremsstrahlung process as a single-electron transition in a static screened central potential. We take for the static potential corresponding to an atom in a hot dense plasma the finite-temperature, finite-density Thomas-Fermi model. This approach corresponds to an average atom in local thermodynamic equilibrium. In comparison to isolated-neutral-atom results we observe general suppression of cross sections and a particular suppression in the tip region of the spectrum. Within this model, both superscreening and shape resonances are found in the circumstances of extreme density. At more normal densities and except for the soft-photon end, the spectrum at these energies for an atom in a hot plasma (characterized by an average degree of ionization) can be well represented by the spectrum of the corresponding isolated ion, which has a similar potential shape at the distances which characterize the process

  12. Photoactivation of the p-nucleus {sup 92}Mo at the bremsstrahlung measurement place of ELBE; Photoaktivierung des p-Kerns {sup 92}Mo am Bremsstrahlungsmessplatz von ELBE

    Energy Technology Data Exchange (ETDEWEB)

    Erhard, Martin Andreas

    2010-02-26

    By the high intensity of the bremsstrahlung of up to 20 MeV to 10{sup 9} MeV{sup -1}cm{sup -2}s{sup -1} in the energy range up to 20 MeV in the framework of this thesis for the first time not only the ({gamma},n), but also the ({gamma},p) reactions could be studied on {sup 92}Mo at astrophysically relevant energies.

  13. Revisiting Bremsstrahlung emission associated with Light Dark Matter annihilations

    CERN Document Server

    Böhm, C

    2006-01-01

    We compute the single bremsstrahlung emission associated with the pair annihilation of spin-0 particles into electrons and positrons, via the t-channel exchange of a heavy fermion. We compare our result with the work of Beacom et al. . Unlike what is stated in the literature, we show that the Bremsstrahlung cross section is not necessarily given by the tree-level annihilation cross section (for a generalized kinematics) times a factor related to the emission of a soft photon. Such a factorization appears only in the soft photon limit or in the approximation where the masses of the particles in the initial and final states are negligible with respect to the mass of the internal particle. However, in the latter case, we do not recover the same factor as for e^+ e- --> mu^+ mu^- gamma. Numerically the difference, in the hard photon limit, is as large as a factor 3.6. However the effect on the upper limit of the dark matter mass is not significant. Using gamma ray observations, we obtain an upper limit on the dar...

  14. Tomographic bremsstrahlung imaging with yttrium-90 in the context of radioembolisation of liver tumors; Tomografische Bildgebung mit Yttrium-90-Bremsstrahlung im Rahmen der Radioembolisation von Lebertumoren

    Energy Technology Data Exchange (ETDEWEB)

    Grosser, Oliver Stephan

    2013-04-12

    Establish tomographic Bremsstrahlung SPECT imaging (BSPECT) for the clinical validation of Selective Internal Radiotherapy (SIRT) with Yttrium-90 ({sup 90}Y) labelled microspheres. Various energy ranges (75 ± 3.8 keV; 135 ± 6.8 keV; 167 ± 8.4 keV) and the summation window were studied to see if they were suitable for BSPECT. To this end, clinically available reconstruction techniques were analysed for their suitability for BSPECT. The tomographic examinations were performed on a cylindrical phantom filled with spheres of different diameters d = [28; 35; 40; 50; 60] mm in a non-active waterfilled background. The spheres were filled with identical {sup 90}Y activity concentration (AC). Measurements were conducted at AC = [14.58; 5.20; 1.98; 0.66] MBq/cm{sup 3}. The BSPECT were reconstructed with filtered back-projection (FBP), a 2D Ordered-Subset Expectation Maximisation Algorithm (2D-OSEM) and a 3D Geometric Mean Algorithm (3D-GMA). Evaluation was made visually and on the basis of objective performance parameters such as contrast, signal-to-noise ratio (SNR) and image noise. While the 75 keV ± 3.8 keV window was identified as suitable for the BSPECT, limitations were revealed as to use of different implementations of the Point Spread Function (PSF). It was found for all reconstruction techniques that, at a given sphere diameter, there existed a linear relationship between the AC in the spheres and the reconstructed pulse rate per volume element. The recovery effect was verified for small spheres. The iterative techniques were found to be suitable for the BSPECT at all AC. At low AC, the 3D-GMA exhibited the least noise and the highest SNR. The FBP turned out to be entirely inappropriate for the BSPECT. The narrow energy window in which the bremsstrahlung interferes with the characteristic X-radiation of lead can be used for BSPECT. In this approach, the tomographic data reconstructed with different algorithms exhibited a varying image quality, with the iterative

  15. Dosimetry and microdosimetry using LET spectrometer based on the track-etch detector: radiotherapy Bremsstrahlung beam, onboard aircraft radiation field

    International Nuclear Information System (INIS)

    Jadrnickova, I.; Spurny, F.

    2006-01-01

    The spectrometer of linear energy transfer (Let) based on the chemically etched poly-allyl-diglycol-carbonate (P.A.D.C.) track-etch detector was developed several years ago in our institute. This Let spectrometer enables determining Let of particles approximately from 10 to 700 keV/μm. From the Let spectra, dose characteristics can be calculated. The contribution presents the Let spectra and other dosimetric characteristics obtained onboard a commercial aircraft during more than 6 months long exposure and in the 18 MV radiotherapy Bremsstrahlung beam. (authors)

  16. Investigation of the reaction {sup 4}He(γ, pn)d at energies below the meson-production threshold

    Energy Technology Data Exchange (ETDEWEB)

    Khodyachikh, A. F.; Gorbenko, E. S.; Murtazin, R. T., E-mail: rumurtazin@gmail.com [Kharkiv Institute of Physics and Technology: National Science Center (Ukraine)

    2017-01-15

    The momentum distributions of deuterons and nucleons from the reaction {sup 4}He(γ, pn)d induced by bremsstrahlung photons whose spectrum extends up to the endpoint energy of 150 MeV were measured by means of a diffusion chamber placed in a magnetic field. These measurements were performed in four photon-energy intervals for deuterons and in the energy range between 100 and 150 MeV for nucleons. Angular and energy correlations of nucleons were measured at photon energies in the interval between 50 and 70 MeV. The results obtained in this way were analyzed on the basis of the quasideuteron model. The probability for final-state nucleon–deuteron interaction was estimated.

  17. Study of nuclear bremsstrahlung in the model independent approach

    International Nuclear Information System (INIS)

    Liu, C.K.

    1980-01-01

    The bremsstrahlung cross section for the scattering of protons by 12 C near the 1.7-MeV resonance has been measured by the Bologna group and the Brooklyn group. In this study, we have included in our calculations the correction terms in the Feshbach-Yennie approximation and have extracted the time delay in the P- 12 C reaction from the data of the Brooklyn group. The + p process near the (1236) has been systematically studied by an experimental group at UCLA. Recently, Liou and Nutt reported a calculation using the soft-photon approximation and their results agree very well with experiment for coplanar events. We have extended their calculation to noncoplanar cases and have found that the soft-photon approximation of Liou and Nutt can describe the experimental data very well not only for coplanar cases but also for noncoplanar cases for most photon angles. In addition, we have also used the Feshbach-Yennie approximation to calculate the + p cross sections. This approximation always predicts a bump in the bremsstrahlung spectrum, although the bump may be small for some photon angles. In most cases, the predicted cross sections are in good agreement with the UCLA data. However, the data for some angles can only be described by the Feshbach-Yennie approximation, and the peak cross section is too large at some angles. We have applied the soft-photon approximation of Liou and Nutt to calculate the proton-proton bremsstrahlung (pp) cross section and have compared our results with the experimental data at 730, 157, 48 and 42 MeV. We have found that we can use the soft-photon approximation to calculate the R-type cross section without any difficulty, but we cannot use the same approximation to predict the H-type cross section without some ambiguity. We have also applied the Feshbach-Yennie approximation to the pp process at 730-MeV taking into account the principal and correction terms

  18. Feasibility studies of a polarized positron source based on the Bremsstrahlung of polarized electrons

    International Nuclear Information System (INIS)

    Dumas, J.

    2011-09-01

    The nuclear and high-energy physics communities have shown a growing interest in the availability of high current, highly-polarized positron beams. A sufficiently energetic polarized photon or lepton incident on a target may generate, via Bremsstrahlung and pair creation within a solid target foil, electron-positron pairs that should carry some fraction of the initial polarization. Recent advances in high current (> 1 mA) spin polarized electron sources at Jefferson Lab offer the perspective of creating polarized positrons from a low energy electron beam. This thesis discusses polarization transfer from electrons to positrons in the perspective of the design optimization of a polarized positron source. The PEPPo experiment, aiming at a measurement of the positron polarization from a low energy (< 10 MeV) highly spin polarized electron beam is discussed. A successful demonstration of this technique would provide an alternative scheme for the production of low energy polarized positrons and useful information for the optimization of the design of polarized positron sources in the sub-GeV energy range. (author)

  19. Establishing a group of endpoints in a parallel computer

    Science.gov (United States)

    Archer, Charles J.; Blocksome, Michael A.; Ratterman, Joseph D.; Smith, Brian E.; Xue, Hanhong

    2016-02-02

    A parallel computer executes a number of tasks, each task includes a number of endpoints and the endpoints are configured to support collective operations. In such a parallel computer, establishing a group of endpoints receiving a user specification of a set of endpoints included in a global collection of endpoints, where the user specification defines the set in accordance with a predefined virtual representation of the endpoints, the predefined virtual representation is a data structure setting forth an organization of tasks and endpoints included in the global collection of endpoints and the user specification defines the set of endpoints without a user specification of a particular endpoint; and defining a group of endpoints in dependence upon the predefined virtual representation of the endpoints and the user specification.

  20. Neutrino-antineutrino pair production by hadronic bremsstrahlung

    Science.gov (United States)

    Bacca, Sonia

    2016-09-01

    I will report on recent calculations of neutrino-antineutrino pair production from bremsstrahlung processes in hadronic collisions and consider temperature conditions relevant for core collapse supernovae. Earlier studies on bremsstrahlung from neutron-neutron collisions showed that the approximation used in typical supernova simulation to model this process differs by about a factor of 2 from predictions based on chiral effective field theory, where the chiral expansion of two-body forces is considered up to the next-to-next-to-next-to-leading order. When the density of neutrons is large enough this process may compete with other non-hadronic reactions in the production of neutrinos, in particular in the case of μ and τ neutrinos, which are not generated by charged-current reactions. A natural question to ask is then: what is the effect of neutrino pair production from collisions of neutrons with finite nuclei? To tackle this question, we recently have addressed the case of neutron- α collisions, given that in the P-wave channels the neutron- α scattering features a resonance near 1 MeV. We find that the resonance leads to an enhanced contribution in the neutron spin structure function at temperatures in the range of 0 . 1 - 4 MeV. For significant density fractions of α in this temperature range, this process is competitive with contributions from neutron-neutron scattering. TRIUMF receives federal funding via a contribution agreement with the National Research Council of Canada. This work was supported in parts by the Natural Sciences and Engineering Research Council (Grant Number SAPIN-2015-0003).

  1. Measurements of Bremsstrahlung radiation and X-ray heat load to cryostat on SECRAL

    International Nuclear Information System (INIS)

    Zhao, H.Y.; Cao, Y.; Lu, W.; Zhang, W.H.; Zhao, H.W.; Zhang, X.Z.; Zhu, Y.H.; Li, X.X.; Xie, D.Z.

    2012-01-01

    The measurement of Bremsstrahlung radiation from ECR (Electron Cyclotron Resonance) plasma can yield certain information about the ECR heating process and the plasma confinement, and more important it can give a plausible estimate of the X-ray heat load to the cryostat of a superconducting ECR source. To better understand the additional heat load to the cryostat due to Bremsstrahlung radiation, the axial Bremsstrahlung measurements have been conducted on SECRAL (Superconducting Electron Cyclotron Resonance ion source with Advanced design in Lanzhou) with different source parameters. In addition, the heat load induced by intense X-ray or even γ-ray was estimated in terms of liquid helium consumption. The relationship between these two parameters is presented here. Thick-target Bremsstrahlung, induced by the collision of hot electrons with the wall or the source electrode, is much more intensive compared with the radiation produced in the plasma and, consequently, much more difficult to shield off. In this paper the presence of the thick-target Bremsstrahlung is correlated with the magnetic confinement configuration, specifically, the ratio of B(last) to B(ext). And possible solutions to reduce the X-ray heat load induced by Bremsstrahlung radiation are proposed and discussed. It appears that by choosing an appropriate ratio of B(last) to B(ext) the thick-target Bremsstrahlung radiation can be avoided effectively. The paper is followed by the associated poster

  2. End-point sharpness in thermometric titrimetry.

    Science.gov (United States)

    Tyrrell, H J

    1967-07-01

    It is shown that the sharpness of an end-point in a thermometric titration where the simple reaction A + B right harpoon over left harpoon AB takes place, depends on Kc(A') where K is the equilibrium constant for the reaction, and c(A') is the total concentration of the titrand (A) in the reaction mixture. The end-point is sharp if, (i) the enthalpy change in the reaction is not negligible, and (ii) Kc(A') > 10(3). This shows that it should, for example, be possible to titrate 0.1 M acid, pK(A) = 10, using a thennometric end-point. Some aspects of thermometric titrimetry when Kc(A') < 10(3) are also considered.

  3. Forecasting interest rates with shifting endpoints

    DEFF Research Database (Denmark)

    Van Dijk, Dick; Koopman, Siem Jan; Wel, Michel van der

    2014-01-01

    We consider forecasting the term structure of interest rates with the assumption that factors driving the yield curve are stationary around a slowly time-varying mean or ‘shifting endpoint’. The shifting endpoints are captured using either (i) time series methods (exponential smoothing) or (ii......) long-range survey forecasts of either interest rates or inflation and output growth, or (iii) exponentially smoothed realizations of these macro variables. Allowing for shifting endpoints in yield curve factors provides substantial and significant gains in out-of-sample predictive accuracy, relative...... to stationary and random walk benchmarks. Forecast improvements are largest for long-maturity interest rates and for long-horizon forecasts....

  4. Ab initio simulation of stimulated bremsstrahlung in an intense laser field

    International Nuclear Information System (INIS)

    Volkova, E.A.; Popov, A.M.; Popovicheva, O.B.

    1992-01-01

    Numerical solution of the time-dependent Schroedinger equation for a quantum system in the field of an electromagnetic wave is used to study a one-dimensional model of stimulated bremsstrahlung (absorption or emission of photons by a field in connection with Coulomb scattering of an electron). The time dependence of the stimulated bremsstrahlung effect is analyzed for various laser radiation intensities. The process of stimulated photorecombination is examined. The results of the calculation are compared with the analytical theory of the stimulated bremsstrahlung effect. 14 refs., 6 figs

  5. Coherent bremsstrahlung and channeling radiation from electrons of one to three MeV in silicon and gold

    International Nuclear Information System (INIS)

    Watson, J.E.

    1981-01-01

    The observation of sharp peaks in the x-ray spectrum from 1 to 3 MeV electrons striking thin single crystals of silicon and gold is reported. These peaks were observed in the range 1 to 25 keV. The peaks are of two different origins, both direct results of the periodic nature of the target crystals. The first kind of radiation is caused by the interference of incoming and scattered electron wave functions. Because of the periodicity of the target material there is a coherence effect for certain bremsstrahlung wave vectors. This coherent bremsstrahlung, though well known at very high electron energies, has never been adequately studied at electron energies below several hundred MeV. Detailed agreement between theoretical prediction and observation in silicon is shown. The second kind of radiation is caused by electrons channeled along major crystal axes. The electrons enter certain quantized orbits as they channel and may emit photons as a consequence of transitions between the various orbits. Observations of channeling radiation for various crystal axes in silicon are presented. Both phenomena were observed in gold, the first such observation for any metallic target

  6. Angular distributions of absorbed dose of Bremsstrahlung and secondary electrons induced by 18-, 28- and 38-MeV electron beams in thick targets.

    Science.gov (United States)

    Takada, Masashi; Kosako, Kazuaki; Oishi, Koji; Nakamura, Takashi; Sato, Kouichi; Kamiyama, Takashi; Kiyanagi, Yoshiaki

    2013-03-01

    Angular distributions of absorbed dose of Bremsstrahlung photons and secondary electrons at a wide range of emission angles from 0 to 135°, were experimentally obtained using an ion chamber with a 0.6 cm(3) air volume covered with or without a build-up cap. The Bremsstrahlung photons and electrons were produced by 18-, 28- and 38-MeV electron beams bombarding tungsten, copper, aluminium and carbon targets. The absorbed doses were also calculated from simulated photon and electron energy spectra by multiplying simulated response functions of the ion chambers, simulated with the MCNPX code. Calculated-to-experimental (C/E) dose ratios obtained are from 0.70 to 1.57 for high-Z targets of W and Cu, from 15 to 135° and the C/E range from 0.6 to 1.4 at 0°; however, the values of C/E for low-Z targets of Al and C are from 0.5 to 1.8 from 0 to 135°. Angular distributions at the forward angles decrease with increasing angles; on the other hand, the angular distributions at the backward angles depend on the target species. The dependences of absorbed doses on electron energy and target thickness were compared between the measured and simulated results. The attenuation profiles of absorbed doses of Bremsstrahlung beams at 0, 30 and 135° were also measured.

  7. Bremsstrahlung hard x-ray source driven by an electron beam from a self-modulated laser wakefield accelerator

    Science.gov (United States)

    Lemos, N.; Albert, F.; Shaw, J. L.; Papp, D.; Polanek, R.; King, P.; Milder, A. L.; Marsh, K. A.; Pak, A.; Pollock, B. B.; Hegelich, B. M.; Moody, J. D.; Park, J.; Tommasini, R.; Williams, G. J.; Chen, Hui; Joshi, C.

    2018-05-01

    An x-ray source generated by an electron beam produced using a Self-Modulated Laser Wakefield Accelerator (SM-LWFA) is explored for use in high energy density science facilities. By colliding the electron beam, with a maximum energy of 380 MeV, total charge of >10 nC and a divergence of 64 × 100 mrad, from a SM-LWFA driven by a 1 ps 120 J laser, into a high-Z foil, an x/gamma-ray source was generated. A broadband bremsstrahlung energy spectrum with temperatures ranging from 0.8 to 2 MeV was measured with an almost 2 orders of magnitude flux increase when compared with other schemes using LWFA. GEANT4 simulations were done to calculate the source size and divergence.

  8. Comparison of positron emission tomography/CT and bremsstrahlung imaging following Y-90 radiation synovectomy

    International Nuclear Information System (INIS)

    Barber, Thomas W.; Yap, Kenneth S.K.; Cherk, Martin H.; Kalff, Victor; Powell, Anne

    2013-01-01

    The aim of this study is to compare the results of positron emission tomography (PET)/CT with bremsstrahlung imaging following Y-90 radiation synovectomy. All patients referred to our institution for Y-90 radiation synovectomy between July 2011 and February 2012 underwent both PET/CT and bremsstrahlung planar (±single photon emission computed tomography (SPECT) or SPECT/CT) imaging at 4 or 24 h following administration of Y-90 silicate colloid. PET image acquisition was performed for between 15 and 20min. In patients who underwent SPECT, side-by-side comparison with PET was performed and image quality/resolution scored using a five-point scale. The distribution pattern of Y-90 on PET and bremsstrahlung imaging was compared with the intra- or extra-articular location of Y-90 activity on fused PET/CT. Thirteen joints (11 knees and two ankles) were imaged with both PET/CT and planar bremsstrahlung imaging with 12 joints also imaged with bremsstrahlung SPECT. Of the 12 joints imaged with SPECT, PET image quality/resolution was superior in 11 and inferior in one. PET demonstrated a concordant distribution pattern compared with bremsstrahlung imaging in all scans, with the pattern classified as diffuse in 12 and predominantly focal in one. In all 12 diffuse scans, PET/CT confirmed the Y-90 activity to be located intra-articularly. In the one predominantly focal scan, the fused PET/CT images localised the Y-90 activity to mostly lie in the extra-articular space of the knee. PET/CT can provide superior image quality compared with bremsstrahlung imaging and may enable reliable detection of extra-articular Y-90 activity when there are focal patterns on planar bremsstrahlung imaging.

  9. Monitoring of energetic characteristics of electron beams during formation of high-power pulsed bremsstrahlung

    International Nuclear Information System (INIS)

    Ivaschenko, D.M.; Mordasov, N.G.; Chlenov, A.M.

    2005-01-01

    A method and a device for monitoring the dynamic and integrated characteristics of high-power electron and bremsstrahlung beams of the pulse accelerators are proposed. The transfer functions for various types of a target in operating conditions of the pulse accelerator UIN-10 are presented. Possibilities if the integrated diagnostics of acceleration rate of the electron beams with simultaneous testing of the bremsstrahlung parameters as a local field point beyond the converting target are shown [ru

  10. Practical reconstruction protocol for quantitative 90Y bremsstrahlung SPECT/CT

    International Nuclear Information System (INIS)

    Siman, W.; Mikell, J. K.; Kappadath, S. C.

    2016-01-01

    Purpose: To develop a practical background compensation (BC) technique to improve quantitative 90 Y-bremsstrahlung single-photon emission computed tomography (SPECT)/computed tomography (CT) using a commercially available imaging system. Methods: All images were acquired using medium-energy collimation in six energy windows (EWs), ranging from 70 to 410 keV. The EWs were determined based on the signal-to-background ratio in planar images of an acrylic phantom of different thicknesses (2–16 cm) positioned below a 90 Y source and set at different distances (15–35 cm) from a gamma camera. The authors adapted the widely used EW-based scatter-correction technique by modeling the BC as scaled images. The BC EW was determined empirically in SPECT/CT studies using an IEC phantom based on the sphere activity recovery and residual activity in the cold lung insert. The scaling factor was calculated from 20 clinical planar 90 Y images. Reconstruction parameters were optimized in the same SPECT images for improved image quantification and contrast. A count-to-activity calibration factor was calculated from 30 clinical 90 Y images. Results: The authors found that the most appropriate imaging EW range was 90–125 keV. BC was modeled as 0.53× images in the EW of 310–410 keV. The background-compensated clinical images had higher image contrast than uncompensated images. The maximum deviation of their SPECT calibration in clinical studies was lowest (<10%) for SPECT with attenuation correction (AC) and SPECT with AC + BC. Using the proposed SPECT-with-AC + BC reconstruction protocol, the authors found that the recovery coefficient of a 37-mm sphere (in a 10-mm volume of interest) increased from 39% to 90% and that the residual activity in the lung insert decreased from 44% to 14% over that of SPECT images with AC alone. Conclusions: The proposed EW-based BC model was developed for 90 Y bremsstrahlung imaging. SPECT with AC + BC gave improved lesion detectability and activity

  11. Practical reconstruction protocol for quantitative {sup 90}Y bremsstrahlung SPECT/CT

    Energy Technology Data Exchange (ETDEWEB)

    Siman, W.; Mikell, J. K.; Kappadath, S. C., E-mail: skappadath@mdanderson.org [Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030 (United States)

    2016-09-15

    Purpose: To develop a practical background compensation (BC) technique to improve quantitative {sup 90}Y-bremsstrahlung single-photon emission computed tomography (SPECT)/computed tomography (CT) using a commercially available imaging system. Methods: All images were acquired using medium-energy collimation in six energy windows (EWs), ranging from 70 to 410 keV. The EWs were determined based on the signal-to-background ratio in planar images of an acrylic phantom of different thicknesses (2–16 cm) positioned below a {sup 90}Y source and set at different distances (15–35 cm) from a gamma camera. The authors adapted the widely used EW-based scatter-correction technique by modeling the BC as scaled images. The BC EW was determined empirically in SPECT/CT studies using an IEC phantom based on the sphere activity recovery and residual activity in the cold lung insert. The scaling factor was calculated from 20 clinical planar {sup 90}Y images. Reconstruction parameters were optimized in the same SPECT images for improved image quantification and contrast. A count-to-activity calibration factor was calculated from 30 clinical {sup 90}Y images. Results: The authors found that the most appropriate imaging EW range was 90–125 keV. BC was modeled as 0.53× images in the EW of 310–410 keV. The background-compensated clinical images had higher image contrast than uncompensated images. The maximum deviation of their SPECT calibration in clinical studies was lowest (<10%) for SPECT with attenuation correction (AC) and SPECT with AC + BC. Using the proposed SPECT-with-AC + BC reconstruction protocol, the authors found that the recovery coefficient of a 37-mm sphere (in a 10-mm volume of interest) increased from 39% to 90% and that the residual activity in the lung insert decreased from 44% to 14% over that of SPECT images with AC alone. Conclusions: The proposed EW-based BC model was developed for {sup 90}Y bremsstrahlung imaging. SPECT with AC + BC gave improved lesion

  12. Bremsstrahlung-Based Imaging and Assays of Radioactive, Mixed and Hazardous Waste

    Science.gov (United States)

    Kwofie, J.; Wells, D. P.; Selim, F. A.; Harmon, F.; Duttagupta, S. P.; Jones, J. L.; White, T.; Roney, T.

    2003-08-01

    A new nondestructive accelerator based x-ray fluorescence (AXRF) approach has been developed to identify heavy metals in large-volume samples. Such samples are an important part of the process and waste streams of U.S Department of Energy sites, as well as other industries such as mining and milling. Distributions of heavy metal impurities in these process and waste samples can range from homogeneous to highly inhomogeneous, and non-destructive assays and imaging that can address both are urgently needed. Our approach is based on using high-energy, pulsed bremsstrahlung beams (3-6.5 MeV) from small electron accelerators to produce K-shell atomic fluorescence x-rays. In addition we exploit pair-production, Compton scattering and x-ray transmission measurements from these beams to probe locations of high density and high atomic number. The excellent penetrability of these beams allows assays and images for soil-like samples at least 15 g/cm2 thick, with elemental impurities of atomic number greater than approximately 50. Fluorescence yield of a variety of targets was measured as a function of impurity atomic number, impurity homogeneity, and sample thickness. We report on actual and potential detection limits of heavy metal impurities in a soil matrix for a variety of samples, and on the potential for imaging, using AXRF and these related probes.

  13. Electron spectroscopy in the fundamental process of electron-nucleus bremsstrahlung

    International Nuclear Information System (INIS)

    Hillenbrand, Pierre-Michel

    2013-07-01

    Within the scope of this thesis the fundamental process of electron-nucleus bremsstrahlung was studied in inverse kinematics at the Experimental Storage Ring ESR at GSI. For the system U 88+ + N 2 at 90 MeV/u it was shown, that by using inverse kinematics coincidence measurements between the scattered electron and the emitted photon can be performed for the case, in which the incoming electron transfers almost all of its kinetic energy onto the emitted photon. The sensitivity to the fundamental process could be achieved by measuring triple differential cross sections as a function of the emission angle of the photon and the scattered electron as well as the energy of the scattered electron. The optics of the magnetic electron spectrometer used were thoroughly revised and optimized to the experimental requirements. Analyzing different coincidences in this collision system, it was possible to determine the contributions to the electron distribution arising from radiative electron capture to the projectile continuum, nonradiative electron capture to the projectile continuum, and electron loss to the projectile continuum. The experimental results of each of these processes were compared to theoretical calculations. The electron spectra for the radiative and the nonradiative electron capture to continuum clearly reproduce the opposite asymmetry predicted by theory. Furthermore electron spectra for collisions of U 28+ with different gases were measured.

  14. Reconstruction of extensive air showers using the MIDAS molecular Bremsstrahlung detector

    International Nuclear Information System (INIS)

    Castro, Andre Ramos de; Bonifazi, Carla; Santos, Edivaldo Moura; Soares, Elvis do Amaral; Mello Neto, Joao Ramos Torres de; Almeida, Rogerio Menezes de

    2011-01-01

    Full text: The weakly ionized plasma created in the atmosphere after the passage of an Extensive Air Shower (EAS) gives rise to the emission of continuous radiation known as Molecular Bremsstrahlung Radiation (MBR) as free electrons scatter off neutral nitrogen (and less frequently oxygen) molecules. The isotropic and unpolarized nature of MBR rises the possibility of an EAS detection similar to that using fluorescence telescopes to capture the ultraviolet light emitted by the ionized nitrogen molecules. The MBR emission, however, falls into the centimeter wavelength range, requiring the use of radio/microwave antennas instead of optical telescopes. In order to test the feasibility of the technique, the MIDAS (Microwave Detection of Air Showers) Collaboration has built a prototype detector where a parabolical reflector illuminates a multi-pixel camera of commercial TV satellite C-band (3.4-4.2 GHz) feeds. This work addresses the geometrical reconstruction of EAS induced by Ultra High Energy Cosmic Rays (UHECR) using the MIDAS detector. The reconstruction chain is similar to that currently applied to the Auger Fluorescence detector events. We have simulated the shower MBR emission assuming two different scenarios: coherent and incoherent emission, i.e., radiation intensity scaling quadratically and linearly with the energy of the primary particle. The MIDAS prototype detector's response is then simulated. Finally, given the simulated events in real data format, we reconstruct the shower's arrival direction, including direction uncertainties and estimate the expected rate of observed events. (author)

  15. Improved quantitative 90 Y bremsstrahlung SPECT/CT reconstruction with Monte Carlo scatter modeling.

    Science.gov (United States)

    Dewaraja, Yuni K; Chun, Se Young; Srinivasa, Ravi N; Kaza, Ravi K; Cuneo, Kyle C; Majdalany, Bill S; Novelli, Paula M; Ljungberg, Michael; Fessler, Jeffrey A

    2017-12-01

    In 90 Y microsphere radioembolization (RE), accurate post-therapy imaging-based dosimetry is important for establishing absorbed dose versus outcome relationships for developing future treatment planning strategies. Additionally, accurately assessing microsphere distributions is important because of concerns for unexpected activity deposition outside the liver. Quantitative 90 Y imaging by either SPECT or PET is challenging. In 90 Y SPECT model based methods are necessary for scatter correction because energy window-based methods are not feasible with the continuous bremsstrahlung energy spectrum. The objective of this work was to implement and evaluate a scatter estimation method for accurate 90 Y bremsstrahlung SPECT/CT imaging. Since a fully Monte Carlo (MC) approach to 90 Y SPECT reconstruction is computationally very demanding, in the present study the scatter estimate generated by a MC simulator was combined with an analytical projector in the 3D OS-EM reconstruction model. A single window (105 to 195-keV) was used for both the acquisition and the projector modeling. A liver/lung torso phantom with intrahepatic lesions and low-uptake extrahepatic objects was imaged to evaluate SPECT/CT reconstruction without and with scatter correction. Clinical application was demonstrated by applying the reconstruction approach to five patients treated with RE to determine lesion and normal liver activity concentrations using a (liver) relative calibration. There was convergence of the scatter estimate after just two updates, greatly reducing computational requirements. In the phantom study, compared with reconstruction without scatter correction, with MC scatter modeling there was substantial improvement in activity recovery in intrahepatic lesions (from > 55% to > 86%), normal liver (from 113% to 104%), and lungs (from 227% to 104%) with only a small degradation in noise (13% vs. 17%). Similarly, with scatter modeling contrast improved substantially both visually and in

  16. Tomography of the fast electron Bremsstrahlung emission during lower hybrid current drive on Tore Supra

    Energy Technology Data Exchange (ETDEWEB)

    Peysson, Y.; Imbeaux, F. [Association Euratom-CEA, CEA/Cadarache, Dept. de Recherches sur la Fusion Controlee (DRFC), 13 - Saint-Paul-lez-Durance (France)

    1999-04-01

    A new tomography dedicated to detailed studies of the fast electron Bremsstrahlung emission in the hard X-ray (HXR) energy range between 20 and 200 keV during lower hybrid (LH) current drive experiments on the TORE SUPRA tokamak [Equipe TORE SUPRA, in Proceedings of the 15. Conference on Plasma Physics and Controlled Nuclear Fusion Research, Seville (International Atomic Energy Agency, Vienna, 1995), 1, AIEA-CN-60 / A1-5, p. 105] is presented. Radiation detection is performed by cadmium telluride(CdTe) semiconductors, which have most of the desirable features for a powerful diagnosing of magnetically confined hot plasmas - compact size, high X-ray stopping efficiency, fast timing characteristics, good energy resolution, no sensitivity to magnetic field, reasonable susceptibility to performance degradation from neutron/{gamma}-induced damages. This instrument is made of two independent cameras viewing a poloidal cross-section of the plasma, with respectively 21 and 38 detectors. A coarse spectrometry - 8 energy channels - is carried out for each chord, with an energy resolution of 20 keV. The spatial resolution in the core of the plasma is 4-5 cm, while the time sampling may be lowered down to of 2-4 ms. Powerful inversion techniques based on maximum entropy or regularization algorithms take fully advantage of the large number of line-integrated measurements for very robust estimates of the local HXR profiles as a function of time and photon energy. A detailed account of main characteristics and performances of the diagnostic is reported as well as preliminary results on LH current drive experiments. (authors)

  17. Tomography of the fast electron Bremsstrahlung emission during lower hybrid current drive on Tore Supra

    International Nuclear Information System (INIS)

    Peysson, Y.; Imbeaux, F.

    1999-04-01

    A new tomography dedicated to detailed studies of the fast electron Bremsstrahlung emission in the hard X-ray (HXR) energy range between 20 and 200 keV during lower hybrid (LH) current drive experiments on the TORE SUPRA tokamak [Equipe TORE SUPRA, in Proceedings of the 15. Conference on Plasma Physics and Controlled Nuclear Fusion Research, Seville (International Atomic Energy Agency, Vienna, 1995), 1, AIEA-CN-60 / A1-5, p. 105] is presented. Radiation detection is performed by cadmium telluride (CdTe) semiconductors, which have most of the desirable features for a powerful diagnosing of magnetically confined hot plasmas - compact size, high X-ray stopping efficiency, fast timing characteristics, good energy resolution, no sensitivity to magnetic field, reasonable susceptibility to performance degradation from neutron/γ-induced damages. This instrument is made of two independent cameras viewing a poloidal cross-section of the plasma, with respectively 21 and 38 detectors. A coarse spectrometry - 8 energy channels - is carried out for each chord, with an energy resolution of 20 keV. The spatial resolution in the core of the plasma is 4-5 cm, while the time sampling may be lowered down to of 2-4 ms. Powerful inversion techniques based on maximum entropy or regularization algorithms take fully advantage of the large number of line-integrated measurements for very robust estimates of the local HXR profiles as a function of time and photon energy. A detailed account of main characteristics and performances of the diagnostic is reported as well as preliminary results on LH current drive experiments. (authors)

  18. Measuring the electron-ion ring parameters by bremsstrahlung

    International Nuclear Information System (INIS)

    Inkin, V.D.; Mozelev, A.A.; Sarantsev, V.P.

    1982-01-01

    A system is described for measuring the number of electrons and ions in the electron-ion rings of a collective heavy ion accelerator. The system operation is based on detecting gamma quanta of bremsstrahlung following the ring electron interaction with the nuclei of neutral atoms and ions at different stages of filling the ring with ions. The radiation detector is a scintillation block - a photomultiplier operating for counting with NaI(Tl) crystal sized 30x30 mm and ensuring the detection efficiency close to unity. The system apparatus is made in the CAMAC standard and rems on-line with the TRA/i miniature computer. The block-diagrams of the system and algorithm of data processing are presented. A conclusion is drawn that the results of measuring the ring parameters with the use of the diagnostics system described are in good agreement within the range of measuring errors with those obtained by means of the diagnostics system employing synchrotron radiation and induction sensors

  19. Photon and proton induced fission on heavy nuclei at intermediate energies

    Energy Technology Data Exchange (ETDEWEB)

    Andrade-II, E.; Karapetyan, G.S.; Deppman, A.; Guimaraes, V. [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Instituto de Fisica; Balabekyan, A.R. [Yerevan State University, Alex Manoogian 1, Yerevan (Armenia); Demekhina, N.A. [Yerevan Physics Institute, Alikhanyan Brothers 2, Yerevan (Armenia); Joint Institute for Nuclear Research (JINR), Flerov Laboratory of Nuclear Reactions (LNR), Moscow (Russian Federation)

    2014-07-01

    We present an analysis of fission induced by intermediate energy protons or photons on actinides. The 660 MeV proton induced reactions are on {sup 241}Am, {sup 238}U, and {sup 237}Np targets and the Bremsstrahlung-photons with end-point energies at 50 MeV and 3500 MeV are on {sup 232}Th and {sup 238}U targets. The study was performed by means of the Monte Carlo simulation code CRISP. A multimodal fission extension was added to the code within an approach which accounts for the contribution of symmetric and asymmetric fission. This procedure allowed the investigation of fission cross sections, fissility, number of evaporated nucleons and fission-fragment charge distributions. The comparison with experimental data show a good agreement between calculations and experiments. (author)

  20. Biomarkers and correlative endpoints for immunotherapy trials.

    Science.gov (United States)

    Morse, Michael A; Osada, Takuya; Hobeika, Amy; Patel, Sandip; Lyerly, H Kim

    2013-01-01

    Immunotherapies for lung cancer are reaching phase III clinical trial, but the ultimate success likely will depend on developing biomarkers to guide development and choosing patient populations most likely to benefit. Because the immune response to cancer involves multiple cell types and cytokines, some spatially and temporally separated, it is likely that multiple biomarkers will be required to fully characterize efficacy of the vaccine and predict eventual benefit. Peripheral blood markers of response, such as the ELISPOT assay and cytokine flow cytometry analyses of peripheral blood mononuclear cells following immunotherapy, remain the standard approach, but it is increasingly important to obtain tissue to study the immune response at the site of the tumor. Earlier clinical endpoints such as response rate and progression-free survival do not correlate with overall survival demonstrated for some immunotherapies, suggesting the need to develop other intermediary clinical endpoints. Insofar as all these biomarkers and surrogate endpoints are relevant in multiple malignancies, it may be possible to extrapolate findings to immunotherapy of lung cancer.

  1. Improved Endpoints for Cancer Immunotherapy Trials

    Science.gov (United States)

    Eggermont, Alexander M. M.; Janetzki, Sylvia; Hodi, F. Stephen; Ibrahim, Ramy; Anderson, Aparna; Humphrey, Rachel; Blumenstein, Brent; Wolchok, Jedd

    2010-01-01

    Unlike chemotherapy, which acts directly on the tumor, cancer immunotherapies exert their effects on the immune system and demonstrate new kinetics that involve building a cellular immune response, followed by changes in tumor burden or patient survival. Thus, adequate design and evaluation of some immunotherapy clinical trials require a new development paradigm that includes reconsideration of established endpoints. Between 2004 and 2009, several initiatives facilitated by the Cancer Immunotherapy Consortium of the Cancer Research Institute and partner organizations systematically evaluated an immunotherapy-focused clinical development paradigm and created the principles for redefining trial endpoints. On this basis, a body of clinical and laboratory data was generated that supports three novel endpoint recommendations. First, cellular immune response assays generate highly variable results. Assay harmonization in multicenter trials may minimize variability and help to establish cellular immune response as a reproducible biomarker, thus allowing investigation of its relationship with clinical outcomes. Second, immunotherapy may induce novel patterns of antitumor response not captured by Response Evaluation Criteria in Solid Tumors or World Health Organization criteria. New immune-related response criteria were defined to more comprehensively capture all response patterns. Third, delayed separation of Kaplan–Meier curves in randomized immunotherapy trials can affect results. Altered statistical models describing hazard ratios as a function of time and recognizing differences before and after separation of curves may allow improved planning of phase III trials. These recommendations may improve our tools for cancer immunotherapy trials and may offer a more realistic and useful model for clinical investigation. PMID:20826737

  2. Laser-assisted collisions: The Kroll-Watson formula and bremsstrahlung theory

    International Nuclear Information System (INIS)

    Geltman, S.

    1996-01-01

    Recent measurements on CO 2 -laser-assisted electron-atom collisions have shown large inconsistencies with the Kroll-Watson formula for small-angle scattering. We have carried out a detailed study to compare the predictions of Kroll-Watson theory (for both single and multimode fields) with those of conventional perturbation theory for stimulated free-free transitions. It is found that for E 0 /2ω 2 <1, where perturbation theory is valid, there are large differences with the Kroll-Watson theory. Comparisons of experimental variations with respect to scattering angle and electron energy show much better agreement with perturbation theory than with Kroll-Watson theory. A study of the angular variations in perturbation theory shows that use of the open-quote open-quote outgoing close-quote close-quote wave final state gives much better agreement with experiment than does the open-quote open-quote ingoing close-quote close-quote wave final state, which is different from the choice made in early bremsstrahlung theory. copyright 1996 The American Physical Society

  3. A second order QCD effect. quark-quark bremsstrahlung contribution to transverse momentum of lepton pairs

    International Nuclear Information System (INIS)

    Chaichian, M.; Hayashi, M.; Honkaranta, T.

    1980-01-01

    We consider in QCD the second order, in gluon-quark coupling constant, contribution of the quark-quark scatte-ring (bremsstrahlung) to the transverse momentum distribution of muon pairs produced in proton-proton collisions. In certain kinematical regions accesible to experimental tests, this contribution is quite large in comparison with the first order calculations. This happens for a specific choice of scale violating structure functions which fit the deep inelastic data. Thus the first order QCD calcula-tion alone is not conclusive in trying to fit the data -one must necessarily check the effect of the second order quark-quark scattering as compared with the first order quark-gluon and the quark-antiquark scattering. This remark concerns also the case when in the first order diagrams the effect of primordial transverse momentum of partons is included as well as the case when the first order is replaced by DDT type of formulae. Mass regularization and different prescriptions for the constant term in q → g + q vertex are considered. Results are presented for the energies √s=6.5, 27, 63, 800 GeV and are compared with experiment. Implications of these results for the detection of W +- -mesons via psub(T) distribution of their decay products μ +- in proton-proton collisions are mentioned. (author)

  4. Endpoint singularities in unintegrated parton distributions

    CERN Document Server

    Hautmann, F

    2007-01-01

    We examine the singular behavior from the endpoint region x -> 1 in parton distributions unintegrated in both longitudinal and transverse momenta. We identify and regularize the singularities by using the subtraction method, and compare this with the cut-off regularization method. The counterterms for the distributions with subtractive regularization are given in coordinate space by compact all-order expressions in terms of eikonal-line operators. We carry out an explicit calculation at one loop for the unintegrated quark distribution. We discuss the relation of the unintegrated parton distributions in subtractive regularization with the ordinary parton distributions.

  5. Proton-proton and neutron-proton bremsstrahlung in the potential model

    International Nuclear Information System (INIS)

    Herrmann, V.

    1993-11-01

    The nucleon-nucleon (NN) bremsstrahlung reaction is studied in the framework of a potential model. We investigate and explain the behavior of the most important corrections to the purely non-relativistic model considering only the external current; i.e. we include the relativistic spin correction, the one-body rescattering contribution and the Coulomb-effect, where it is needed. The important contribution of the two-body or meson-exchange current is treated in the soft-photon-approximation. In addition to the usual coplanar NNγ cross section we also study non-coplanar cross sections and spin observables like the analyzing power and spin correlation coefficients. It is shown that the behavior of the relativistic spin correction is governed by the 1 S 0 partial-wave state, is almost energy independent and reduces the NNγ cross section by roughly 20 - 30%. The one-body rescattering contribution enhances the ppγ cross section for the geometry of the last TRIUMF experiment by about 20% and thus almost compensates the effect of the relativistic spin corrections. The effects of each part of the NN interaction on the ppγ observables is studied in the coplanar geometry. We find that these effects depend on the proton scattering angles as well as on the considered observable. However, the tensor component of the NN interaction is important in all geometries. The comparison of different NN potential models yields that the NNγ reaction is not able to discriminate these potentials in their off-shell behavior, although the corresponding T-matrices deviate from each other off the energy shell. It is concluded that the occuring differences originate already from deviations on the energy shell or from the fact that the approximations made in the calculations for the two-body current are not of the same quality for all NN potential models. (orig.)

  6. Helicopter EMS: Research Endpoints and Potential Benefits

    Directory of Open Access Journals (Sweden)

    Stephen H. Thomas

    2012-01-01

    Full Text Available Patients, EMS systems, and healthcare regions benefit from Helicopter EMS (HEMS utilization. This article discusses these benefits in terms of specific endpoints utilized in research projects. The endpoint of interest, be it primary, secondary, or surrogate, is important to understand in the deployment of HEMS resources or in planning further HEMS outcomes research. The most important outcomes are those which show potential benefits to the patients, such as functional survival, pain relief, and earlier ALS care. Case reports are also important “outcomes” publications. The benefits of HEMS in the rural setting is the ability to provide timely access to Level I or Level II trauma centers and in nontrauma, interfacility transport of cardiac, stroke, and even sepsis patients. Many HEMS crews have pharmacologic and procedural capabilities that bring a different level of care to a trauma scene or small referring hospital, especially in the rural setting. Regional healthcare and EMS system's benefit from HEMS by their capability to extend the advanced level of care throughout a region, provide a “backup” for areas with limited ALS coverage, minimize transport times, make available direct transport to specialized centers, and offer flexibility of transport in overloaded hospital systems.

  7. Routine average effective charge calculation using visible Bremsstrahlung emission and comparison with the impurity transport code of Tore Supra

    International Nuclear Information System (INIS)

    Guirlet, R.; Mattioli, M.; DeMichelis, C.; Hess, W.; Pecquet, A.L.

    1995-01-01

    Effective charge measurements and calculations are presented for the Tore Supra, using visible Bremsstrahlung diagnostics. The measurements, are presented together with a reliability test of the results are discussed, by means of an impurity transport code simulating all available experimental data (XUV line spectroscopy, soft X-ray emission and Bremsstrahlung). (author) 5 refs.; 10 figs

  8. Extracting gluino endpoints with event topology patterns

    Energy Technology Data Exchange (ETDEWEB)

    Pietsch, N. [Hamburg Univ. (Germany). Inst. fuer Experimentalphysik; Reuter, J.; Sakurai, K.; Wiesler, D. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2012-06-15

    In this paper we study the gluino dijet mass edge measurement at the LHC in a realistic situation including both SUSY and combinatorical backgrounds together with effects of initial and final state radiation as well as a finite detector resolution. Three benchmark scenarios are examined in which the dominant SUSY production process and also the decay modes are different. Several new kinematical variables are proposed to minimize the impact of SUSY and combinatorial backgrounds in the measurement. By selecting events with a particular number of jets and leptons, we attempt to measure two distinct gluino dijet mass edges originating from wino g {yields} jjW and bino g {yields}jjB decay modes, separately. We determine the endpoints of distributions of proposed and existing variables and show that those two edges can be disentangled and measured within good accuracy, irrespective of the presence of ISR, FSR, and detector effects.

  9. Radiological endpoints relevant to ecological risk assessment

    International Nuclear Information System (INIS)

    Harrison, F.

    1997-01-01

    Because of the potential risk from radiation due to the releases of radionuclides from anthropogenic activities, considerable research was performed to determine for humans the levels of dose received, their responses to the doses and mechanisms of action of radioactivity on living matter. More recently, there is an increased interest in the effects of radioactivity on non-human species. There are differences in approach between risk assessment for humans and ecosystems. For protection of humans, the focus is the individual and the endpoint of primary concern is cancer induction. For protection of ecosystems, the focus is on population stability and the endpoint of concern is reproductive success for organisms important ecologically and economically. For these organisms, information is needed on their responses to irradiation and the potential impact of the doses absorbed on their reproductive success. Considerable information is available on the effects of radiation on organisms from different phyla and types of ecosystems. Databases useful for assessing risk from exposures of populations to radioactivity are the effects of irradiation on mortality, fertility and sterility, the latter two of which are important components of reproductive success. Data on radiation effects on mortality are available both from acute and chronic irradiation. In relation to radiation effects, reproductive success for a given population is related to a number of characteristics of the species, including inherent radiosensitivity of reproductive tissues and early life stages, processes occurring during gametogenesis, reproductive strategy and exposure history. The available data on acute and chronic radiation doses is reviewed for invertebrates, fishes and mammals. The information reviewed indicates that wide ranges in responses with species can be expected. Parameters that most likely contribute to inherent radiosensitivity are discussed. (author)

  10. The nucleon-nucleon interaction in the presence of the electromagnetic field: Nucleon-nucleon bremsstrahlung

    International Nuclear Information System (INIS)

    Brown, V.R.

    1990-01-01

    Nucleon-nucleon bremsstrahlung, NNγ, is a fundamental process, which involves the strong and electromagnetic fields acting simultaneously. Since the electromagnetic interaction is well known, NNγ provides a calculable tool for comparing off-energy-shell effects from different two-nucleon potentials compared to experiment and also provides a simple testing ground, which is sensitive to meson-exchange-current contributions that are so important in electronuclear physics. Historically, experimental studies have focused on ppγ, with only a few measurements of npγ. The present workshop was organized primarily to investigate the interest in, the value of, and the feasibility of doing an npγ experiment using the neutron white source at LANL. An increasing amount of US nuclear physics dollars are being spent on electronuclear physics. npγ is a fundamental process with large meson-exchange currents. In the npγ calculations of Brown and Franklin, the meson-exchange contributions increase the cross section by a factor of roughly two and later the angular distribution of the emitted photon dramatically. The details of these calculated effects have never been verified experimentally, but the proper quantum-mechanical inclusion of meson-exchange contributions, using the methods of brown and Franklin, has proved to be essential in understanding the heavy-ion results. The understanding of the importance of such terms is extremely important inelectronuclear processes, such as are presently under investigation or being planned at Bates, SLAC, and CEBAF. Just one example is in the electrodisintegration of the deuteron, where meson-exchange contributions must be included properly before any conclusions about nuclear models, such as QCD versus meson-exchange potentials can be made

  11. The intermediate endpoint effect in logistic and probit regression

    Science.gov (United States)

    MacKinnon, DP; Lockwood, CM; Brown, CH; Wang, W; Hoffman, JM

    2010-01-01

    Background An intermediate endpoint is hypothesized to be in the middle of the causal sequence relating an independent variable to a dependent variable. The intermediate variable is also called a surrogate or mediating variable and the corresponding effect is called the mediated, surrogate endpoint, or intermediate endpoint effect. Clinical studies are often designed to change an intermediate or surrogate endpoint and through this intermediate change influence the ultimate endpoint. In many intermediate endpoint clinical studies the dependent variable is binary, and logistic or probit regression is used. Purpose The purpose of this study is to describe a limitation of a widely used approach to assessing intermediate endpoint effects and to propose an alternative method, based on products of coefficients, that yields more accurate results. Methods The intermediate endpoint model for a binary outcome is described for a true binary outcome and for a dichotomization of a latent continuous outcome. Plots of true values and a simulation study are used to evaluate the different methods. Results Distorted estimates of the intermediate endpoint effect and incorrect conclusions can result from the application of widely used methods to assess the intermediate endpoint effect. The same problem occurs for the proportion of an effect explained by an intermediate endpoint, which has been suggested as a useful measure for identifying intermediate endpoints. A solution to this problem is given based on the relationship between latent variable modeling and logistic or probit regression. Limitations More complicated intermediate variable models are not addressed in the study, although the methods described in the article can be extended to these more complicated models. Conclusions Researchers are encouraged to use an intermediate endpoint method based on the product of regression coefficients. A common method based on difference in coefficient methods can lead to distorted

  12. Virtual-bremsstrahlung production in proton-proton scattering and proton-deuteron capture

    NARCIS (Netherlands)

    Messchendorp, Johannes Gerhardus

    1999-01-01

    The well-known coupling of the photon with the nucleon together with the fact that photons (or any electromagnetic (e.m.) probe) interact only relatively weakly with nucleons, make bremsstrahlung production an ideal tool to study details of the nucleon-nucleon interaction. In this thesis dilepton

  13. Lepton-pair production by bremsstrahlung in central relativistic heavy ion collisions

    International Nuclear Information System (INIS)

    Lippert, T.; Becker, U.; Gruen, N.; Scheid, W.; Soff, G.

    1988-03-01

    We study the production of lepton-pairs by classical bremsstrahlung in central relativistic heavy-ion collisions. For the stopping of the nuclei we assume a simple model of point charges and a deceleration time. Pair creation probabilities are calculated in first order perturbation theory. (orig.)

  14. ''Atomic'' Bremsstrahlung or polarizational radiation in collision of many-electron ions

    International Nuclear Information System (INIS)

    Amusia, M.Ya.; Solov'yov, A.V.

    1991-01-01

    In this work the so-called ''Atomic'' bremsstrahlung (AB) or polarizational radiation, created in collisions of atoms or ions, is discussed. This kind of radiation arises due to the polarization of the electron shell of colliding particles. It is created by the structured projectiles and targets if the constituents are electrically charged. 6 refs, 2 figs

  15. Pauli principle in the soft-photon approach to proton-proton bremsstrahlung

    NARCIS (Netherlands)

    Liou, MK; Timmermans, R; Gibson, BF

    1996-01-01

    A relativistic and manifestly gauge-invariant soft-photon amplitude, which is consistent with the soft-photon theorem and satisfies the Pauli principle, is derived for the proton-proton bremsstrahlung process. This soft-photon amplitude is the first two-u-two-t special amplitude to satisfy all

  16. Multi-Regge amplitudes for bremsstrahlung in e+e- backward scattering

    International Nuclear Information System (INIS)

    Ermolaev, B.I.; Lipatov, L.N.

    1988-01-01

    Using the method of factorization, equations are obtained for the inelastic on-shell amplitudes describing the asymptotic behavior of e + e - backward scattering with emission of bremsstrahlung photons in the doubly logarithmic approximation. Explicit expressions are found for these amplitudes in the case in which the photons are emitted with multi-Regge kinematics

  17. Endpoint distinctiveness facilitates analogical mapping in pigeons.

    Science.gov (United States)

    Hagmann, Carl Erick; Cook, Robert G

    2015-03-01

    Analogical thinking necessitates mapping shared relations across two separate domains. We investigated whether pigeons could learn faster with ordinal mapping of relations across two physical dimensions (circle size & choice spatial position) relative to random mapping of these relations. Pigeons were trained to relate six circular samples of different sizes to horizontally positioned choice locations in a six alternative matching-to-sample task. Three pigeons were trained in a mapped condition in which circle size mapped directly onto choice spatial position. Three other pigeons were trained in a random condition in which the relations between size and choice position were arbitrarily assigned. The mapped group showed an advantage over the random group in acquiring this task. In a subsequent second phase, relations between the dimensions were ordinally reversed for the mapped group and re-randomized for the random group. There was no difference in how quickly matching accuracy re-emerged in the two groups, although the mapped group eventually performed more accurately. Analyses suggested this mapped advantage was likely due to endpoint distinctiveness and the benefits of proximity errors during choice responding rather than a conceptual or relational advantage attributable to the common or ordinal mapping of the two dimensions. This potential difficulty in mapping relations across dimensions may limit the pigeons' capacity for more advanced types of analogical reasoning. This article is part of a Special Issue entitled: Tribute to Tom Zentall. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. Endpoint Distinctiveness Facilitates Analogical Mapping in Pigeons

    Science.gov (United States)

    Hagmann, Carl Erick; Cook, Robert G.

    2015-01-01

    Analogical thinking necessitates mapping shared relations across two separate domains. We investigated whether pigeons could learn faster with ordinal mapping of relations across two physical dimensions (circle size & choice spatial position) relative to random mapping of these relations. Pigeons were trained to relate six circular samples of different sizes to horizontally positioned choice locations in a six alternative matching-to-sample task. Three pigeons were trained in a mapped condition in which circle size mapped directly onto choice spatial position. Three other pigeons were trained in a random condition in which the relations between size and choice position were arbitrarily assigned. The mapped group showed an advantage over the random group in acquiring this task. In a subsequent second phase, reassignment, relations between the dimensions were ordinally reversed for the mapped group and re-randomized for the random group. There was no difference in how quickly matching accuracy re-emerged in the two groups, although the mapped group eventually performed more accurately. Analyses suggested this mapped advantage was likely due endpoint distinctiveness and the benefits of proximity errors during choice responding rather than a conceptual or relational advantage attributable to the common or ordinal map of the two dimensions. This potential difficulty in mapping relations across dimensions may limit the pigeons’ capacity for more advanced types of analogical reasoning. PMID:25447511

  19. Improvement of gamma-ray Sn transport calculations including coherent and incoherent scatterings and secondary sources of bremsstrahlung and fluorescence: Determination of gamma-ray buildup factors

    International Nuclear Information System (INIS)

    Kitsos, S.; Diop, C.M.; Assad, A.; Nimal, J.C.; Ridoux, P.

    1996-01-01

    Improvements of gamma-ray transport calculations in S n codes aim at taking into account the bound-electron effect of Compton scattering (incoherent), coherent scattering (Rayleigh), and secondary sources of bremsstrahlung and fluorescence. A computation scheme was developed to take into account these phenomena by modifying the angular and energy transfer matrices, and no modification in the transport code has been made. The incoherent and coherent scatterings as well as the fluorescence sources can be strictly treated by the transfer matrix change. For bremsstrahlung sources, this is possible if one can neglect the charged particles path as they pass through the matter (electrons and positrons) and is applicable for the energy range of interest for us (below 10 MeV). These improvements have been reported on the kernel attenuation codes by the calculation of new buildup factors. The gamma-ray buildup factors have been carried out for 25 natural elements up to 30 mean free paths in the energy range between 15 keV and 10 MeV

  20. High-power, photofission-inducing bremsstrahlung source for intense pulsed active detection of fissile material

    Directory of Open Access Journals (Sweden)

    J. C. Zier

    2014-06-01

    Full Text Available Intense pulsed active detection (IPAD is a promising technique for detecting fissile material to prevent the proliferation of special nuclear materials. With IPAD, fissions are induced in a brief, intense radiation burst and the resulting gamma ray or neutron signals are acquired during a short period of elevated signal-to-noise ratio. The 8 MV, 200 kA Mercury pulsed-power generator at the Naval Research Laboratory coupled to a high-power vacuum diode produces an intense 30 ns bremsstrahlung beam to study this approach. The work presented here reports on Mercury experiments designed to maximize the photofission yield in a depleted-uranium (DU object in the bremsstrahlung far field by varying the anode-cathode (AK diode gap spacing and by adding an inner-diameter-reducing insert in the outer conductor wall. An extensive suite of diagnostics was fielded to measure the bremsstrahlung beam and DU fission yield as functions of diode geometry. Delayed fission neutrons from the DU proved to be a valuable diagnostic for measuring bremsstrahlung photons above 5 MeV. The measurements are in broad agreement with particle-in-cell and Monte Carlo simulations of electron dynamics and radiation transport. These show that with increasing AK gap, electron losses to the insert and outer conductor wall increase and that the electron angles impacting the bremsstrahlung converter approach normal incidence. The diode conditions for maximum fission yield occur when the gap is large enough to produce electron angles close to normal, yet small enough to limit electron losses.

  1. Using bremsstrahlung for electron density estimation and correction in EAST tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yingjie, E-mail: bestfaye@gmail.com; Wu, Zhenwei; Gao, Wei; Jie, Yinxian; Zhang, Jizong; Huang, Juan; Zhang, Ling; Zhao, Junyu

    2013-11-15

    Highlights: • The visible bremsstrahlung diagnostic provides a simple and effective tool for electron density estimation in steady state discharges. • This method can make up some disadvantages of present FIR and TS diagnostics in EAST tokamak. • Line averaged electron density has been deduced from central VB signal. The results can also be used for FIR n{sub e} correction. • Typical n{sub e} profiles have been obtained with T{sub e} and reconstructed bremsstrahlung profiles. -- Abstract: In EAST electron density (n{sub e}) is measured by the multi-channel far-infrared (FIR) hydrogen cyanide (HCN) interferometer and Thomson scattering (TS) diagnostics. However, it is difficult to obtain accurate n{sub e} profile for that there are many problems existing in current electron density diagnostics. Since the visible bremsstrahlung (VB) emission coefficient has a strong dependence on electron density, the visible bremsstrahlung measurement system developed to determine the ion effective charge (Z{sub eff}) may also be used for n{sub e} estimation via inverse operations. With assumption that Z{sub eff} has a flat profile and does not change significantly in steady state discharges, line averaged electron density (n{sup ¯}{sub e}) has been deduced from VB signals in L-mode and H-mode discharges in EAST. The results are in good coincidence with n{sup ¯}{sub e} from FIR, which proves that VB measurement is an effective tool for n{sub e} estimation. VB diagnostic is also applied to n{sup ¯}{sub e} correction when FIR n{sup ¯}{sub e} is wrong for the laser phase shift reversal together with noise causes errors when electron density changed rapidly in the H-mode discharges. Typical n{sub e} profiles in L-mode and H-mode phase are also deduced with reconstructed bremsstrahlung profiles.

  2. High-power, photofission-inducing bremsstrahlung source for intense pulsed active detection of fissile material

    Science.gov (United States)

    Zier, J. C.; Mosher, D.; Allen, R. J.; Commisso, R. J.; Cooperstein, G.; Hinshelwood, D. D.; Jackson, S. L.; Murphy, D. P.; Ottinger, P. F.; Richardson, A. S.; Schumer, J. W.; Swanekamp, S. B.; Weber, B. V.

    2014-06-01

    Intense pulsed active detection (IPAD) is a promising technique for detecting fissile material to prevent the proliferation of special nuclear materials. With IPAD, fissions are induced in a brief, intense radiation burst and the resulting gamma ray or neutron signals are acquired during a short period of elevated signal-to-noise ratio. The 8 MV, 200 kA Mercury pulsed-power generator at the Naval Research Laboratory coupled to a high-power vacuum diode produces an intense 30 ns bremsstrahlung beam to study this approach. The work presented here reports on Mercury experiments designed to maximize the photofission yield in a depleted-uranium (DU) object in the bremsstrahlung far field by varying the anode-cathode (AK) diode gap spacing and by adding an inner-diameter-reducing insert in the outer conductor wall. An extensive suite of diagnostics was fielded to measure the bremsstrahlung beam and DU fission yield as functions of diode geometry. Delayed fission neutrons from the DU proved to be a valuable diagnostic for measuring bremsstrahlung photons above 5 MeV. The measurements are in broad agreement with particle-in-cell and Monte Carlo simulations of electron dynamics and radiation transport. These show that with increasing AK gap, electron losses to the insert and outer conductor wall increase and that the electron angles impacting the bremsstrahlung converter approach normal incidence. The diode conditions for maximum fission yield occur when the gap is large enough to produce electron angles close to normal, yet small enough to limit electron losses.

  3. Sample size determination for equivalence assessment with multiple endpoints.

    Science.gov (United States)

    Sun, Anna; Dong, Xiaoyu; Tsong, Yi

    2014-01-01

    Equivalence assessment between a reference and test treatment is often conducted by two one-sided tests (TOST). The corresponding power function and sample size determination can be derived from a joint distribution of the sample mean and sample variance. When an equivalence trial is designed with multiple endpoints, it often involves several sets of two one-sided tests. A naive approach for sample size determination in this case would select the largest sample size required for each endpoint. However, such a method ignores the correlation among endpoints. With the objective to reject all endpoints and when the endpoints are uncorrelated, the power function is the production of all power functions for individual endpoints. With correlated endpoints, the sample size and power should be adjusted for such a correlation. In this article, we propose the exact power function for the equivalence test with multiple endpoints adjusted for correlation under both crossover and parallel designs. We further discuss the differences in sample size for the naive method without and with correlation adjusted methods and illustrate with an in vivo bioequivalence crossover study with area under the curve (AUC) and maximum concentration (Cmax) as the two endpoints.

  4. Ordered kinematic endpoints for 5-body cascade decays

    Energy Technology Data Exchange (ETDEWEB)

    Klimek, Matthew D. [Theory Group, Department of Physics and Texas Cosmology Center,University of Texas at Austin, 2515 Speedway, Stop C1608, Austin, TX, 78712 (United States)

    2016-12-23

    We present expressions for the kinematic endpoints of 5-body cascade decay chains proceeding through all possible combinations of 2-body and 3-body decays, with one stable invisible particle in the final decay stage. When an invariant mass can be formed in multiple ways by choosing different final state particles from a common vertex, we introduce techniques for finding the sub-leading endpoints for all indistinguishable versions of the invariant mass. In contrast to short decay chains, where sub-leading endpoints are linearly related to the leading endpoints, we find that in 5-body decays, they provide additional independent constraints on the mass spectrum.

  5. Numerical investigation into the highly nonlinear heat transfer equation with bremsstrahlung emission in the inertial confinement fusion plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Habibi, M.; Oloumi, M.; Hosseinkhani, H.; Magidi, S. [Plasma and Fusion Research School, Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of)

    2015-10-15

    A highly nonlinear parabolic partial differential equation that models the electron heat transfer process in laser inertial fusion has been solved numerically. The strong temperature dependence of the electron thermal conductivity and heat loss term (Bremsstrahlung emission) makes this a highly nonlinear process. In this case, an efficient numerical method is developed for the energy transport mechanism from the region of energy deposition into the ablation surface by a combination of the Crank-Nicolson scheme and the Newton-Raphson method. The quantitative behavior of the electron temperature and the comparison between analytic and numerical solutions are also investigated. For more clarification, the accuracy and conservation of energy in the computations are tested. The numerical results can be used to evaluate the nonlinear electron heat conduction, considering the released energy of the laser pulse at the Deuterium-Tritium (DT) targets and preheating by heat conduction ahead of a compression shock in the inertial confinement fusion (ICF) approach. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  6. Test of Compton camera components for prompt gamma imaging at the ELBE bremsstrahlung beam

    Science.gov (United States)

    Hueso-González, F.; Golnik, C.; Berthel, M.; Dreyer, A.; Enghardt, W.; Fiedler, F.; Heidel, K.; Kormoll, T.; Rohling, H.; Schöne, S.; Schwengner, R.; Wagner, A.; Pausch, G.

    2014-05-01

    In the context of ion beam therapy, particle range verification is a major challenge for the quality assurance of the treatment. One approach is the measurement of the prompt gamma rays resulting from the tissue irradiation. A Compton camera based on several position sensitive gamma ray detectors, together with an imaging algorithm, is expected to reconstruct the prompt gamma ray emission density map, which is correlated with the dose distribution. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), a Compton camera setup is being developed consisting of two scatter planes: two CdZnTe (CZT) cross strip detectors, and an absorber consisting of one Lu2SiO5 (LSO) block detector. The data acquisition is based on VME electronics and handled by software developed on the ROOT framework. The setup has been tested at the linear electron accelerator ELBE at HZDR, which is used in this experiment to produce bunched bremsstrahlung photons with up to 12.5 MeV energy and a repetition rate of 13 MHz. Their spectrum has similarities with the shape expected from prompt gamma rays in the clinical environment, and the flux is also bunched with the accelerator frequency. The charge sharing effect of the CZT detector is studied qualitatively for different energy ranges. The LSO detector pixel discrimination resolution is analyzed and it shows a trend to improve for high energy depositions. The time correlation between the pulsed prompt photons and the measured detector signals, to be used for background suppression, exhibits a time resolution of 3 ns FWHM for the CZT detector and of 2 ns for the LSO detector. A time walk correction and pixel-wise calibration is applied for the LSO detector, whose resolution improves up to 630 ps. In conclusion, the detector setup is suitable for time-resolved background suppression in pulsed clinical particle accelerators. Ongoing tasks are the quantitative comparison with simulations and the test of imaging algorithms. Experiments at proton

  7. Test of Compton camera components for prompt gamma imaging at the ELBE bremsstrahlung beam

    International Nuclear Information System (INIS)

    Hueso-González, F; Golnik, C; Berthel, M; Dreyer, A; Enghardt, W; Kormoll, T; Rohling, H; Pausch, G; Fiedler, F; Heidel, K; Schöne, S; Schwengner, R; Wagner, A

    2014-01-01

    In the context of ion beam therapy, particle range verification is a major challenge for the quality assurance of the treatment. One approach is the measurement of the prompt gamma rays resulting from the tissue irradiation. A Compton camera based on several position sensitive gamma ray detectors, together with an imaging algorithm, is expected to reconstruct the prompt gamma ray emission density map, which is correlated with the dose distribution. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), a Compton camera setup is being developed consisting of two scatter planes: two CdZnTe (CZT) cross strip detectors, and an absorber consisting of one Lu 2 SiO 5 (LSO) block detector. The data acquisition is based on VME electronics and handled by software developed on the ROOT framework. The setup has been tested at the linear electron accelerator ELBE at HZDR, which is used in this experiment to produce bunched bremsstrahlung photons with up to 12.5 MeV energy and a repetition rate of 13 MHz. Their spectrum has similarities with the shape expected from prompt gamma rays in the clinical environment, and the flux is also bunched with the accelerator frequency. The charge sharing effect of the CZT detector is studied qualitatively for different energy ranges. The LSO detector pixel discrimination resolution is analyzed and it shows a trend to improve for high energy depositions. The time correlation between the pulsed prompt photons and the measured detector signals, to be used for background suppression, exhibits a time resolution of 3 ns FWHM for the CZT detector and of 2 ns for the LSO detector. A time walk correction and pixel-wise calibration is applied for the LSO detector, whose resolution improves up to 630 ps. In conclusion, the detector setup is suitable for time-resolved background suppression in pulsed clinical particle accelerators. Ongoing tasks are the quantitative comparison with simulations and the test of imaging algorithms. Experiments at proton

  8. The efficiency of a bremsstrahlung interrogator: Beam Research Program

    International Nuclear Information System (INIS)

    Barletta, W.A.

    1987-08-01

    One can estimate the energetics of using gamma radiation produced by a high energy electron beam as a means of ascertaining the mass of distant objects. Several approaches to converting beam energy to radiation are compared, including a nonmaterial ''beamsstrahlung'' converter. 4 refs., 7 figs

  9. A bremsstrahlung gamma-ray source based on stable ionization injection of electrons into a laser wakefield accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Döpp, A., E-mail: andreas.doepp@polytechnique.edu [LOA, ENSTA ParisTech, CNRS, École polytechnique, Université Paris-Saclay, 828 bd des Maréchaux, 91762 Palaiseau Cedex (France); Centro de Laseres Pulsados, Parque Cientfico, 37185 Villamayor, Salamanca (Spain); Guillaume, E.; Thaury, C.; Lifschitz, A. [LOA, ENSTA ParisTech, CNRS, École polytechnique, Université Paris-Saclay, 828 bd des Maréchaux, 91762 Palaiseau Cedex (France); Sylla, F. [SourceLAB SAS, 86 rue de Paris, 91400 Orsay (France); Goddet, J-P.; Tafzi, A.; Iaquanello, G.; Lefrou, T.; Rousseau, P. [LOA, ENSTA ParisTech, CNRS, École polytechnique, Université Paris-Saclay, 828 bd des Maréchaux, 91762 Palaiseau Cedex (France); Conejero, E.; Ruiz, C. [Departamento de Física Aplicada, Universidad de Salamanca, Plaza de laMerced s/n, 37008 Salamanca (Spain); Ta Phuoc, K.; Malka, V. [LOA, ENSTA ParisTech, CNRS, École polytechnique, Université Paris-Saclay, 828 bd des Maréchaux, 91762 Palaiseau Cedex (France)

    2016-09-11

    Laser wakefield acceleration permits the generation of ultra-short, high-brightness relativistic electron beams on a millimeter scale. While those features are of interest for many applications, the source remains constraint by the poor stability of the electron injection process. Here we present results on injection and acceleration of electrons in pure nitrogen and argon. We observe stable, continuous ionization-induced injection of electrons into the wakefield for laser powers exceeding a threshold of 7 TW. The beam charge scales approximately with the laser energy and is limited by beam loading. For 40 TW laser pulses we measure a maximum charge of almost 1 nC per shot, originating mostly from electrons of less than 10 MeV energy. The relatively low energy, the high charge and its stability make this source well-suited for applications such as non-destructive testing. Hence, we demonstrate the production of energetic radiation via bremsstrahlung conversion at 1 Hz repetition rate. In accordance with GEANT4 Monte-Carlo simulations, we measure a γ-ray source size of less than 100 μm for a 0.5 mm tantalum converter placed at 2 mm from the accelerator exit. Furthermore we present radiographs of image quality indicators.

  10. Hippeastrum hybridum anthocyanins as indicators of endpoint in acid

    African Journals Online (AJOL)

    Anthocyanins from Hippeastrum hybridum (Amaryllis) were investigated as indicators of endpoint in acid- base titrations. Extraction of the anthocyanins was done using distilled water, methanol and methanol containing 0.5% acetic acid. The extracts were used in determination of endpoint in titrations between strong.

  11. Hippeastrum hybridum anthocyanins as indicators of endpoint in ...

    African Journals Online (AJOL)

    Anthocyanins from Hippeastrum hybridum (Amaryllis) were investigated as indicators of endpoint in acid- base titrations. Extraction of the anthocyanins was done using distilled water, methanol and methanol containing 0.5% acetic acid. The extracts were used in determination of endpoint in titrations between strong ...

  12. The impact of endpoint measures in rheumatoid arthritis clinical trials

    NARCIS (Netherlands)

    van der Heide, A.; Jacobs, J. W.; Dinant, H. J.; Bijlsma, J. W.

    1992-01-01

    In clinical trials on the effectiveness of disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA), it is common to apply a large number of endpoint measures. This practice has several disadvantages. To determine which endpoint measures are most valuable, reports of

  13. Detour effects on inner Bremsstrahlung from 91Y

    International Nuclear Information System (INIS)

    Narayana, D.G.S.; Narasimha Murty, K.; Subrahmanyam, V.V.V.

    1976-01-01

    Contribution of detour transitions to internal bresstrahlung (IB) is estimated using the recent calculations of Ford and Martin. The IB spectrum of 91 Y is measured by using a multichannel NaI(Tl) scintillation spectrometer with a standard geometrical arrangement. After effecting all the necessary corrections, the total yields of intensity and of energy of IB are determined and compared with the corresponding theoretical (detour and direct) values of Ford and Martin in the investigated energy region from 100 to 1250 keV. The present experimental results are almost coinciding with the detour corrected theory in the energy region from 200 to 600 keV and below 200 keV and above 650 keV, the experiment is deviating positively from even this detour theory. The divergence between experiment and theory is found to increase with increasing energy. (author)

  14. Energetic endpoints provide early indicators of life history effects in a freshwater gastropod exposed to the fungicide, pyraclostrobin

    International Nuclear Information System (INIS)

    Fidder, Bridgette N.; Reátegui-Zirena, Evelyn G.; Olson, Adric D.; Salice, Christopher J.

    2016-01-01

    Organismal energetics provide important insights into the effects of environmental toxicants. We aimed to determine the effects of pyraclostrobin on Lymnaea stagnalis by examining energy allocation patterns and life history traits. Juvenile snails exposed to pyraclostrobin decreased feeding rate and increased apparent avoidance behaviors at environmentally relevant concentrations. In adults, we found that sublethal concentrations of pyraclostrobin did not affect reproductive output, however, there were significant effects on developmental endpoints with longer time to hatch and decreased hatching success in pyraclostrobin-exposed egg masses. Further, there were apparent differences in developmental effects depending on whether mothers were also exposed to pyraclostrobin suggesting this chemical can exert intergenerational effects. Pyraclostrobin also affected protein and carbohydrate content of eggs in mothers that were exposed to pyraclostrobin. Significant effects on macronutrient content of eggs occurred at lower concentrations than effects on gross endpoints such as hatching success and time to hatch suggesting potential value for these endpoints as early indicators of ecologically relevant stress. These results provide important insight into the effects of a common fungicide on important endpoints for organismal energetics and life history. - Highlights: • We exposed a freshwater snail to relevant concentrations of pyraclostrobin. • We monitored energetic and life history endpoints. • Pyraclostrobin affected feeding, hatching success and egg macronutrient content. • Energetic-based endpoints may provide valuable insight to toxic effects. - The fungicide pyraclostrobin at environmentally relevant concentrations effects a range of life history and energetic endpoints in the freshwater snail, Lymnaea stagnalis.

  15. Observation of the bremsstrahlung generation in the process of the Rayleigh endash Taylor instability development at gas puff implosion

    International Nuclear Information System (INIS)

    Baksht, R.B.; Fedunin, A.V.; Labetsky, A.Y.; Rousskich, A.G.; Shishlov, A.V.

    1997-01-01

    The electron magnetohydrodynamic model predicts the appearance of anode endash cathode voltage in the process of Rayleigh endash Taylor instability development during gas puff implosions. The appearance of the anode endash cathode voltage should be accompanied by the accelerated electron flow and the generation of the bremsstrahlung radiation. Experiments with neon and krypton gas puffs were performed on the GIT-4 [S. P. Bugaev, et al., Plasma Sci. 18, 115 (1990)] generator (1.6 MA, 120 ns) to observe the bremsstrahlung radiation during the gas puff implosion. Two spikes of the bremsstrahlung radiation were observed in the experiments. The first spike is connected with the gas breakdown; the second one is connected with the final stage of the implosion. The development of the RT instabilities does not initiate the bremsstrahlung radiation, therefore, the absence of anode endash cathode voltage is demonstrated. copyright 1997 American Institute of Physics

  16. Bremsstrahlung pair-production of positrons with low neutron background

    International Nuclear Information System (INIS)

    Lessner, E.

    1998-01-01

    Minimization of component activation is highly desirable at accelerator-based positron sources. Electrons in the 8- to 14-MeV energy range impinging on a target produce photons energetic enough to create electron-positron pairs; however, few of the photons are energetic enough to produce photoneutrons. Slow positron production by low-energy electrons impinging on a multilayer tungsten target with and without electromagnetic extraction between the layers was studied by simulation. The neutron background from 14-MeV electrons is expected to be significantly lower than that encountered with higher-energy electron beams. Numerical results are presented and some ideas for a low-activation slow-positron source are discussed

  17. Determination of the temperature of bremsstrahlung photon generated by ultraintense laser using various thickness attenuators

    International Nuclear Information System (INIS)

    Hasegawa, Shuichi; Takashima, Ryuta; Todoriki, Masaru; Kikkawa, Satoshi; Soda, Keita; Takano, Kei; Oishi, Yuji; Nayuki, Takuya; Fujii, Takashi; Nemoto, Koshichi

    2011-01-01

    We evaluate the simplified method using the Lambert-Beer law to measure the temperature of bremsstrahlung photon generated by an ultraintense laser. Analytical values are compared to the results of the Monte Carlo calculation of GEANT4 and they agreed very well on the condition of the appropriate distance between the attenuator and the detector. We performed the experiment to measure the temperature of bremsstrahlung x-ray emitted from a metal target irradiated by a Ti:sapphire laser with 76 mJ, 72 fs, 2.2 x 10 18 W/cm 2 . For a Cu target of 30 μm thick, the photon temperature was reasonably determined to be 0.18 MeV, which is in good agreement with previous studies.

  18. Study on the feasibilities of nondestructive testing based on bremsstrahlung albedo

    International Nuclear Information System (INIS)

    Zhalsaraev, B.Zh.; Meshcheryakov, R.P.

    1980-01-01

    Presented are the results of experimental studies of the characteristics of gamma radiation reflected from homogeneous and laminated targets irradiated by 15 MeV betatron bremsstrahlung. Considered are the possibilities of simultaneous testing of thickness and of effective atomic number of materials, identification of heterogeneity of their structure, determination of the parameters of the media which are concealed by the layers of light substances of considerable thickness. The results obtained testify the usability of bremsstrahlung backscattering for contactless or remote control and differentiation of various media and objects, for the analysis and prospecting of surface ore manifestation and for processing control at the concentrating mills as well. The efficiency of the above method is underlined

  19. One-spin asymmetries in pair production and Bremsstrahlung processes

    International Nuclear Information System (INIS)

    Arbuzov, A.B.; Kuraev, E.A.; Tarasov, A.V.; Merenkov, N.P.; Peresun'ko, D.Yu.

    1995-01-01

    Asymmetries in the interaction processes at high energies of circularly polarized photons or longitudinally polarized electrons with charged targets are considered. The derivations are shown in detail. The asymmetries are shown to be proportional to the degree of polarization of the initial particle, they do not decrease with increasing of the energy and could reach several percents for pure QED processes or tens percents in the case of a quark-antiquark jets production. Transverse to the beam direction components of the outgoing particle momenta are assumed to be large compared with the electron (quark) mass. 6 refs., 3 tabs

  20. An algorithm to include the bremsstrahlung component in the determination of the absorbed dose in electron beams

    Energy Technology Data Exchange (ETDEWEB)

    Klevenhagen, S C [The Royal London Hospital, London (United Kingdom). Medical Physics Dept.

    1996-08-01

    Currently used dosimetry protocols for absolute dose determination of electron beams from accelerators in radiation therapy do not account for the effect of the bremsstrahlung contamination of the beam. This results in slightly erroneous doses calculated from ionization chamber measurements. In this report the deviation is calculated and an improved algorithm, which accounts for the effect of the bremsstrahlung component of the beam, is suggested. (author). 14 refs, 2 figs, 1 tab.

  1. One-loop corrections to the process e+e-→tt including hard bremsstrahlung

    International Nuclear Information System (INIS)

    Fleischer, J.; Riemann, T.; Werthenbach, A.; Leike, A.

    2002-03-01

    Radiative corrections to the process e + e - → t anti t are calculated in one-loop approximation of the Standard Model. There exist results from several groups. This talk provides further comparisons of the complete electroweak contributions, including hard bremsstrahlung. The excellent final agreement of the different groups allows to continue by working on a code for an event generator for TESLA and an extension to e + e - → 6 fermions. (orig.)

  2. Instrumental neutron activation analysis of phosphorus in biological materials by Bremsstrahlung measurement

    International Nuclear Information System (INIS)

    Bajo, S.; Wyttenbach, A.

    1986-12-01

    The determination of phosphorus in biological materials by instrumental neutron activation via the reaction 31 P (n,γ) 32 P is described. The Bremsstrahlung produced by 32 P is measured in a well-type NaI(Tl) detector. The samples are measured within the polyethylene irradiation container with no changes between irradiation and measurement. The sources of error were studied and the proposed method was applied to the determination of phosphorus in ten internationally certified materials. (author)

  3. Note on Inverse Bremsstrahlung in a Strong Electromagnetic Field

    Science.gov (United States)

    Bethe, H. A.

    1972-09-01

    The collisional energy loss of an electron undergoing forced oscillation in an electromagnetic field behaves quite differently in the low and high intensity limits. ... It is shown that in the case of an electromagnetic field v {sub o} >> v {sub t} the rate of transfer is much slower, and actually decreases with the strength of the field.

  4. Comparison of the effect of soft-core potentials and Coulombic potentials on bremsstrahlung during laser matter interaction

    Science.gov (United States)

    Pandit, Rishi R.; Becker, Valerie R.; Barrington, Kasey; Thurston, Jeremy; Ramunno, Lora; Ackad, Edward

    2018-04-01

    An intense, short laser pulse incident on rare-gas clusters can produce nano-plasmas containing energetic electrons. As these electrons undergo scattering, from both phonons and ions, they emit bremsstrahlung radiation. Here, we compare a theory of bremsstrahlung emission appropriate for the interaction of intense lasers with matter using soft-core potentials and Coulombic potentials. A new scaling for the radiation cross-section and the radiated power via bremsstrahlung is derived for a soft-core potential (which depends on the potential depth) and compared with the Coulomb potential. Calculations using the new scaling are performed for electrons in vacuum ultraviolet, infrared and mid-infrared laser pulses. The radiation cross-section and the radiation power via bremsstrahlung are found to increase rapidly with increases in the potential depth of up to around 200 eV and then become mostly saturated for larger depths while remaining constant for the Coulomb potential. In both cases, the radiation cross-section and the radiation power of bremsstrahlung decrease with increases in the laser wavelength. The ratio of the scattering amplitude for the soft-core potential and that for the Coulombic potential decreases exponentially with an increase in momentum transfer. The bremsstrahlung emission by electrons in plasmas may provide a broadband light source for diagnostics.

  5. Resonant parametric interference effect in spontaneous bremsstrahlung of an electron in the field of a nucleus and two pulsed laser waves

    Science.gov (United States)

    Lebed', A. A.; Padusenko, E. A.; Roshchupkin, S. P.; Dubov, V. V.

    2018-04-01

    Electron-nucleus bremsstrahlung in the field of two moderately strong pulsed laser waves in the case of incommensurate frequencies is theoretically studied under resonant conditions. The process is studied in detail in a special kinematic region, where stimulated processes with correlated emission and absorption of photons of the first and second waves become predominant (parametric interference effect). The availability of this region is caused by interference of the first and second laser waves. The correspondence between the emission angle and the final-electron energy is established in this interference kinematic. In this case, the cross-sectional properties are determined by the multiphoton quantum interference parameter, which is proportional to the product of intensities of the first and second waves. The resonant differential cross section of electron-nucleus spontaneous bremsstrahlung with simultaneous registration of both emission angles of the spontaneous photon and the scattered electron can exceed by four or five orders of magnitude the corresponding cross section in the absence of an external field. It was shown for nonrelativistic electrons that the resonant cross section of the studied process in the field of two pulsed laser waves within the interference region in two order of magnitude may exceed corresponding cross sections at other scattering kinematics. The obtained results may be experimentally verified, for example, by scientific facilities at sources of pulsed laser radiation (such as SLAC, FAIR, XFEL, ELI).

  6. Semi-empirical model to determine pure β--emitters in closed waste packages using Bremsstrahlung radiation

    International Nuclear Information System (INIS)

    Takacs, S.; Hermanne, A.

    2001-01-01

    unsealed pure β - -emitting isotopes are applied. The 3 H, 35 S, 32 P and 33 P are widely used for DNA sequencing studies. Also large amount of 3 H and 14 C are used in organic compound synthesis resulting in long-lived low-level radioactive waste. The β - -particles can be detected by beta counter but it is not applicable in the case of closed waste packages, since the β - - particles loss their energy quickly and they are not capable to escape from the sealed waste package. The emitted β - -particles have continuous energy spectrum and no direct gamma radiation follow the decay. The only means of detection of these β - -particles is through the Bremsstrahlung radiation produced while the particle slows down. The cross section of the Bremsstrahlung generation process depends on the initial energy of the slowing down β - - particles and is proportional to the atomic density n and the average Z 2 of the waste matrix. The probability of this process is much lower than that of the ionisation process for beta particles but it is still high enough to produce measurable amounts of photons. We studied the 35 S and 32 P pure β - -emitter sources in sealed waste packages. The continuous nature of the Bremsstrahlung radiation prevents us using the 'full-energy photo peak area' method. Instead a Region of Interest (ROI) was defined. Unlike for the full-energy photo peak method where the detector efficiency is calculated in the function of energy, for pure β - - emitters an optimised ROI was defined in the spectrum and a special efficiency, eps*beta(E) was determined. The used geometry and the nature of the waste matrix requires time consuming efficiency calibrations of the detector system to be able to establish an efficiency - (matrix density, geometry, matrix composition, activity distribution) function. We studied experimentally the possible deviations of the eps*beta(E) function in case of non uniform activity distribution in order to be able to model the associated error

  7. Evidence for Hard Gluon Bremsstrahlung in a Neutrino Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Sokoloff, Michael David [Univ. of California, Berkeley, CA (United States)

    1983-06-01

    The uncorrelated jet model (UJM) and the hydrodynamical model for particle production in very high energy scattering of two protons have been investigated. The differential cross-section for elastic scattering has been calculated in the UJM with Regge phase and the shrinkage of the diffraction peak has been discussed . Inclusive two-particle correlations due to energy-momentum conservation have been computed in the UJM and compared to experiment. Statistical quantities for particle production have been defined using t he analogy between the phase-space integral in particle production and the definition of the grand canonical partition function in statistical mechanics. The statistical quantities have been used in the hydrodynamical model of Landau to calculate the inclusive single particle rapidity distribution for pions and thermodynamical properties of the two colliding hadrons .

  8. Ecosystem services as assessment endpoints for ecological risk assessment.

    Science.gov (United States)

    Munns, Wayne R; Rea, Anne W; Suter, Glenn W; Martin, Lawrence; Blake-Hedges, Lynne; Crk, Tanja; Davis, Christine; Ferreira, Gina; Jordan, Steve; Mahoney, Michele; Barron, Mace G

    2016-07-01

    Ecosystem services are defined as the outputs of ecological processes that contribute to human welfare or have the potential to do so in the future. Those outputs include food and drinking water, clean air and water, and pollinated crops. The need to protect the services provided by natural systems has been recognized previously, but ecosystem services have not been formally incorporated into ecological risk assessment practice in a general way in the United States. Endpoints used conventionally in ecological risk assessment, derived directly from the state of the ecosystem (e.g., biophysical structure and processes), and endpoints based on ecosystem services serve different purposes. Conventional endpoints are ecologically important and susceptible entities and attributes that are protected under US laws and regulations. Ecosystem service endpoints are a conceptual and analytical step beyond conventional endpoints and are intended to complement conventional endpoints by linking and extending endpoints to goods and services with more obvious benefit to humans. Conventional endpoints can be related to ecosystem services even when the latter are not considered explicitly during problem formulation. To advance the use of ecosystem service endpoints in ecological risk assessment, the US Environmental Protection Agency's Risk Assessment Forum has added generic endpoints based on ecosystem services (ES-GEAE) to the original 2003 set of generic ecological assessment endpoints (GEAEs). Like conventional GEAEs, ES-GEAEs are defined by an entity and an attribute. Also like conventional GEAEs, ES-GEAEs are broadly described and will need to be made specific when applied to individual assessments. Adoption of ecosystem services as a type of assessment endpoint is intended to improve the value of risk assessment to environmental decision making, linking ecological risk to human well-being, and providing an improved means of communicating those risks. Integr Environ Assess Manag

  9. Planning and analyzing clinical trials with composite endpoints

    CERN Document Server

    Rauch, Geraldine; Kieser, Meinhard

    2017-01-01

    This book addresses the most important aspects of how to plan and evaluate clinical trials with a composite primary endpoint to guarantee a clinically meaningful and valid interpretation of the results. Composite endpoints are often used as primary efficacy variables for clinical trials, particularly in the fields of oncology and cardiology. These endpoints combine several variables of interest within a single composite measure, and as a result, all variables that are of major clinical relevance can be considered in the primary analysis without the need to adjust for multiplicity. Moreover, composite endpoints are intended to increase the size of the expected effects thus making clinical trials more powerful. The book offers practical advice for statisticians and medical experts involved in the planning and analysis of clinical trials. For readers who are mainly interested in the application of the methods, all the approaches are illustrated with real-world clinical trial examples, and the software codes requ...

  10. Gastroenterological endpoints in drug trials for cystic fibrosis

    NARCIS (Netherlands)

    Bodewes, Frank A. J. A.; Verkade, Henkjan J.; Wilschanski, Micheal

    2016-01-01

    The phenotype of cystic fibrosis includes a wide variety of clinical and biochemical gastrointestinal presentations. These gastrointestinal characteristics of the disease have come under renewed interest as potential outcome measures and clinical endpoints for therapeutic trials in cystic fibrosis.

  11. Comparisons of angularly and spectrally resolved Bremsstrahlung measurements to two-dimensional multi-stage simulations of short-pulse laser-plasma interactions

    Energy Technology Data Exchange (ETDEWEB)

    Chen, C. D.; Kemp, A. J.; Pérez, F.; Link, A.; Key, M. H.; McLean, H.; Ping, Y.; Patel, P. K. [Lawrence Livermore National Laboratory (United States); Beg, F. N.; Chawla, S.; Sorokovikova, A.; Westover, B. [University of California, San Diego (United States); Morace, A. [University of Milan (Italy); Stephens, R. B. [General Atomics (United States); Streeter, M. [Imperial College London (United Kingdom)

    2013-05-15

    A 2-D multi-stage simulation model incorporating realistic laser conditions and a fully resolved electron distribution handoff has been developed and compared to angularly and spectrally resolved Bremsstrahlung measurements from high-Z planar targets. For near-normal incidence and 0.5-1 × 10{sup 20} W/cm{sup 2} intensity, particle-in-cell (PIC) simulations predict the existence of a high energy electron component consistently directed away from the laser axis, in contrast with previous expectations for oblique irradiation. Measurements of the angular distribution are consistent with a high energy component when directed along the PIC predicted direction, as opposed to between the target normal and laser axis as previously measured.

  12. Preliminary remediation goals for ecological endpoints

    International Nuclear Information System (INIS)

    Efroymson, R.A.; Suter, G.W. II; Sample, B.E.; Jones, D.S.

    1996-07-01

    Preliminary remediation goals (PRGs) are useful for risk assessment and decision making at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) sites. PRGs are upper concentration limits for specific chemicals in specific environmental media that are anticipated to protect human health or the environment. They can be used for multiple remedial investigations at multiple facilities. In addition to media and chemicals of potential concern, the development of PRGs generally requires some knowledge or anticipation of future land use. In Preliminary Remediation Goals for Use at the U.S. Department of Energy Oak Ridge Operations Office (Energy Systems 1995), PRGs intended to protect human health were developed with guidance from Risk Assessment Guidance for Superfund: Volume I - Human Health Evaluation Manual, Part B (RAGS) (EPA 1991). However, no guidance was given for PRGs based on ecological risk. The numbers that appear in this volume have, for the most part, been extracted from toxicological benchmarks documents for Oak Ridge National Laboratory (ORNL) and have previously been developed by ORNL. The sources of the quantities, and many of the uncertainties associated with their derivation, are described in this technical memorandum

  13. Preliminary remediation goals for ecological endpoints

    International Nuclear Information System (INIS)

    Efroymson, R.A.; Suter, G.W. II.

    1995-09-01

    Preliminary remediation goals (PRGs) are useful for risk assessment and decision making at Comprehensive Environmental Response, compensation, and Liability Act (CERCLA) sites. PRGs are upper concentration limits for specific chemicals in specific environmental media that are anticipated to protect human health or the environment. They can be used for multiple remedial investigations at multiple facilities. In addition to media and chemicals of potential concern, the development of PRGs generally requires some knowledge or anticipation of future land use. In Preliminary Remediation Goals for Use at the US Department of Energy Oak Ridge Operations Office (Energy Systems 1995), PRGs intended to protect human health were developed with guidance from Risk Assessment Guidance for Superfund: Volume I-Human Health Evaluation Manual, Part B (RAGS) (EPA 1991). However, no guidance was given for PRGs based on ecological risk. The numbers that appear in this volume have, for the most part, been extracted from toxicological benchmarks documents for Oak Ridge National Laboratory (ORNL) and have previously been developed by ORNL. The sources of the quantities, and many of the uncertainties associated with their derivation, are described in this technical memorandum

  14. Dose calculations using MARS for Bremsstrahlung beam stops and collimators in APS beamline stations.

    Energy Technology Data Exchange (ETDEWEB)

    Dooling, J.; Accelerator Systems Division (APS)

    2010-11-01

    The Monte Carlo radiation transport code MARS is used to model the generation of gas bremsstrahlung (GB) radiation from 7-GeV electrons which scatter from residual gas atoms in undulator straight sections within the Advanced Photon Source (APS) storage ring. Additionally, MARS is employed to model the interactions of the GB radiation with components along the x-ray beamlines and then determine the expected radiation dose-rates that result. In this manner, MARS can be used to assess the adequacy of existing shielding or the specifications for new shielding when required. The GB radiation generated in the 'thin-target' of an ID straight section will consist only of photons in a 1/E-distribution up to the full energy of the stored electron beam. Using this analytical model, the predicted GB power for a typical APS 15.38-m insertion device (ID) straight section is 4.59 x 10{sup -7} W/nTorr/mA, assuming a background gas composed of air (Z{sub eff} = 7.31) at room temperature (293K). The total GB power provides a useful benchmark for comparisons between analytical and numerical approaches. We find good agreement between MARS and analytical estimates for total GB power. The extended straight section 'target' creates a radial profile of GB, which is highly peaked centered on the electron beam. The GB distribution reflects the size of the electron beam that creates the radiation. Optimizing the performance of MARS in terms of CPU time per incident trajectory requires the use of a relatively short, high-density gas target (air); in this report, the target density is {rho}L = 2.89 x 10{sup -2} g/cm{sup 2} over a length of 24 cm. MARS results are compared with the contact dose levels reported in TB-20, which used EGS4 for radiation transport simulations. Maximum dose-rates in 1 cc of tissue phantom form the initial basis for comparison. MARS and EGS4 results are approximately the same for maximum 1-cc dose-rates and attenuation in the photon

  15. Biochemical endpoints of glucocorticoid hormone action

    Energy Technology Data Exchange (ETDEWEB)

    Young, D.A.; Nicholson, M.L.; Guyette, W.A.; Giddings, S.J.; Mendelsohn, S.L.; Nordeen, S.K.; Lyons, R.T.

    1978-01-01

    Both the rapidly evolving metabolic effects of glucocorticoids and the more slowly developing lethal actions appear to be initiated via the synthesis of new mRNAs and proteins. The chronic suppression of cell growth may be the consequence of suppression of overall rates of protein synthesis (and probably RNA and DNA synthesis as well) that in turn may represent the cellular response to the small changes in ratios of adenine nucleotides that result from the suppression of oxidative ATP production. The inhibition of glucose transport may also play a role here to prevent a compensatory increase in glycolytic ATP production. Some other hormone actions, the decrease in the ability of cells to concentrate AIB and the increase in nuclear fragility are unrelated to, and evolve separately from, the hormonal inhibitions on energy production. Cell killing is not the result of suppression of protein synthesis, nor of hormone-induced increases in calcium uptake. While the mechanisms are unknown, the increase in nuclear fragility appears to be the earliest measure of their operation. In tumor cells resistance to lethal actions of glucocorticoids may emerge via the selection of cells with hardier membranes, that are better able to withstand the intracellular destructive events set in motion by high levels of glucocorticoids.

  16. Studies of cluster X-ray sources. Energy spectra for the Perseus, Virgo, and Coma clusters

    International Nuclear Information System (INIS)

    Kellogg, E.; Baldwin, J.R.; Koch, D.

    1975-01-01

    We present the final Uhuru X-ray differential-energy spectra for the Perseus, Virgo, and Coma clusters of galaxies. The power-law and isothermal bremsstrahlung model forms, both with a low-energy cutoff, are given. For bremsstrahlung, the energy-dependent Gaunt factor is calculated by an improved method. The spectra, best fits to the Uhuru 2-10 keV data, are also compared with other observations of these sources in the energy range 0.1-100 keV. For Perseus, the data above 20 keV favor the bremsstrahlung fit marginally. For Virgo, the data of Catura et al. between 0.25 and 1.0 keV clearly favor the bremsstrahlung curve. For Coma, the weakest of the three sources, the data are less precise, but there is some evidence for a low-energy turnover or cutoff. The implications of such a cutoff are discussed briefly

  17. Observation of material, thickness, and bremsstrahlung x-ray intensity dependent effects in moderate and high Z targets in a gamma and x-ray LIDAR experiment

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xiaodong, E-mail: xzhang39@utk.edu [Department of Nuclear Engineering, University of Tennessee, TN 37996 (United States); Ayaz-Maierhafer, Birsen; Laubach, Mitchell A. [Department of Nuclear Engineering, University of Tennessee, TN 37996 (United States); Hayward, Jason P. [Department of Nuclear Engineering, University of Tennessee, TN 37996 (United States); Oak Ridge National Lab, Oak Ridge, TN 37831 (United States)

    2015-06-01

    A high energy gamma and x-ray LIDAR system consisting of a fast pulse (~50 ps, FWHM) LINAC and a Cherenkov detection system was used to investigate response differences among materials, their thicknesses, and bremsstrahlung x-ray intensities. The energies and pulse width of electrons used to produce bremsstrahlung x-rays were set at 20 or 40 MeV and 50 ps FWHM duration, respectively. The Cherenkov detector was built with a fused silica glass optically coupled to a 51 mm fast timing photomultiplier tube, which has an intrinsic energy threshold of 340.7 keV for Compton backscattered gammas. Such a fast detection system yields a coincidence resolving time of 93 ps FWHM, which is equivalent to a depth resolving capability of about 3 cm FWHM. The thicknesses of iron and lead targets were varied from 1 in. to 7 in. with a step of 1 in., and the thicknesses of DU were varied from 1/3 in. to 1 in. with a step of 1/3 in. The experimental results show that iron targets tend to produce a factor of five less observed x-rays and gammas, with less energetic photoelectron frequency distributions, compared with DU and lead targets for the same beam intensity and target thicknesses. Additionally, the self-shielding effect causes the lead to yield more gammas than the DU considering the experimental observation point. For the setup used in this study, a charge per pulse in the range of 1–2.5 nC yields the best resolving capability between the DU and lead targets.

  18. A Comparison of Laser-induced Bremsstrahlung and Laser Compton Scattering for (γ, n) Photo-transmutation of Hazardous Nuclear Waste

    International Nuclear Information System (INIS)

    Rehman, Haseeb ur; Lee, Jiyoung; Kim, Yonghee

    2015-01-01

    This paper also presents sensitivity analysis to yield the maximum possible photo-transmutation rates. In general the possibility of radionuclide transmutation using photo-neutron reaction is evaluated in this work. In this paper a detailed methodology to calculate transmutation reaction rates using Laser Induced Bremsstrahlung (LIB) and Laser Compton Scattering (LCS) has been discussed. The methodology was validated by comparing the calculated reaction rates against published data in publically accessed literatures. In the second half of the paper, the authors present a novel concept to narrow down the LCS photon spectrum to an energy range that matches with the resonance region of a particular radionuclide. This is particularly useful considering hazardous waste is usually a mix of different isotopes. As such, being able to tune the LCS photon into any narrow energy range so as to selectively transmute any particular isotope of interest in the hazardous waste mixture would be very desirable. LCS spectrum is highly sensitive to the electron beam energy, laser power, laser luminosity and Compton backscattering angle. From the results it is quite evident that LCS is much better option for the radionuclide transmutation as reaction rates for the LCS is much higher than LIB method even for very small laser power. It can be seen even for the optimistic reaction rate calculations with Bremsstrahlung method reaction rate is much lower than LCS case for 10 Hz repetition rate. If repetition rate of laser 100 Hz then LIB reaction rate has the same order of the magnitude as the reaction rate via LCS. Higher Laser Powers can yield very high transmutation rates

  19. Measurements of bremsstrahlung spectra of Lanzhou ECR Ion Source No. 3 (LECR3)

    International Nuclear Information System (INIS)

    Zhao, H.Y.; Zhao, H.W.; Ma, X.W.; Zhang, S.F.; Feng, W.T.; Zhu, X.L.; Zhang, Z.M.; He, W.; Sun, L.T.; Feng, Y.C.; Cao, Y.; Li, J.Y.; Li, X.X.; Wang, H.; Ma, B.H.

    2006-01-01

    In order to diagnose the electron cyclotron resonance (ECR) plasma, electron bremsstrahlung spectra were measured by a HPGe detector on Lanzhou ECR Ion Source No. 3 at IMP. The ion source was operated with argon under various working conditions, including different microwave power, mixing gas, extraction high voltage (HV), and so on. Some of the measured spectra are presented in this article. The dependence of energetic electron population on mixing gas and extraction HV is also described. Additionally, we are looking forward to further measurements on SECRAL (Superconducting ECR Ion Source with Advanced design at Lanzhou)

  20. Spectral tomographic analysis of Bremsstrahlung X-rays generated in a laser-produced plasma

    Czech Academy of Sciences Publication Activity Database

    Rhee, Y.-J.; Nam, S. M.; Peebles, W.; Sawada, H.; Wei, M.; Vaisseau, X.; Sasaki, T.; Giuffrida, Lorenzo; Hulin, S.; Vauzour, B.; Santos, J.J.; Batani, D.; McLean, H. S.; Patel, P. K.; Li, Y.; Yuan, D. W.; Zhang, K.; Zhong, J. Y.; Fu, C. B.; Hua, N.; Li, K.; Zhang, Y.; Zhu, J. Q.; Kim, I. J.; Jeon, J. H.; Jeong, T.M.; Choi, I.W.; Lee, H. W.; Sung, J.H.; Lee, S.K.; Nam, C.H.

    2016-01-01

    Roč. 34, č. 4 (2016), s. 645-654 ISSN 0263-0346 R&D Projects: GA MŠk LQ1606; GA MŠk EF15_008/0000162 Grant - others:ELI Beamlines(XE) CZ.02.1.01/0.0/0.0/15_008/0000162 Institutional support: RVO:68378271 Keywords : Bremsstrahlung X-ray * filter stack spectrometer * laser-produced plasma Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 1.420, year: 2016

  1. Cooling effect in emissions of 103mRh excited by bremsstrahlung

    International Nuclear Information System (INIS)

    Cheng, Y; Xia, B; Chen, C P

    2009-01-01

    Nonlinear characteristic emissions of Kα, Kβ and γ with a significant triplet splitting at room temperature are observed from the long-lived nuclear state of 103m Rh excited by bremsstrahlung irradiation. A pronounced phase-transition-like narrowing of the emission profiles occurs immediately after the sample is cooled down to 77 K. The room temperature profiles reappear again abruptly and almost reversibly as the temperature drifts freely back to approximately the ice point after the filling with liquid nitrogen is stopped. These emission properties at 300 K and at low temperature may indicate that the 103m Rh nuclei are in collective states.

  2. Optimization of the linear induction accelerator construction for maximizing the bremsstrahlung output

    Energy Technology Data Exchange (ETDEWEB)

    Zinchenko, V F; Tulisov, E V; Chlenov, A M; Shiyan, V D [Research Institute of Scientific Instruments, Turaevo-Lytkarino (Russian Federation)

    1997-12-31

    The results of experimental and theoretical optimization of the linear induction accelerator (LIA) design are presented. The major aim of the investigations was to maximize the bremsstrahlung output near the target face. The work was carried out in two stages: l) modernization of the injector module and 2) focusing of the relativistic electron beam (REB) produced at the exit of the accelerating system (AS) in the increasing axial magnetic field. In addition, the methods of diagnostics of angular and energetic parameters of REB based on measurements of radiation dose fields behind the target are described. (author). 2 figs., 4 refs.

  3. Experimental study of the electron-atom Bremsstrahlung emission in an argon plasma jet

    International Nuclear Information System (INIS)

    Ranson, P.; Vallee, O.; Chapelle, J.

    1977-01-01

    Electron-neutral atom bremsstrahlung is studied between 0.4 μm and 5 μm in a decaying argon plasma jet; in visible and infra-red range, some discrepancies appear between experimental results and theoretical calculations of different authors (Geltman, Stallcop). In the infra-red, the discrepancy can be partly explained because theoretical elastic cross sections are higher than experimental values in the vicinity of the Ramsauer minimum. In the visible range, a very small amount of fast electrons due to superelastic and recombination collisions explain the observed discrepancy [fr

  4. Angular distribution of the bremsstrahlung emission during lower-hybrid current drive on PLT

    International Nuclear Information System (INIS)

    von Goeler, S.; Stevens, J.; Bernabei, S.

    1985-06-01

    The bremsstrahlung emission from the PLT tokamak during lower-hybrid current drive has been measured as a function of angle between the magnetic field and the emission direction. The emission is peaked strongly in the forward direction, indicating a strong anisotropy of the electron-velocity distribution. The data demonstrate the existence of a nearly flat tail of the velocity distribution, which extends out to approximately 500 keV and which is interpreted as the plateau created by Landau damping of the lower-hybrid waves

  5. Internal bremsstrahlung accompanying non-unique second-forbidden β-decay of 36Cl

    International Nuclear Information System (INIS)

    Basha, A.M.; Khalil, E.I.; Hussein, M.; Ragab, H.S.; El-Konsol, S.

    1991-01-01

    The inner Bremsstrahlung spectrum (I.B.) associated with the non-unique second forbidden β-transition of 36 Cl was measured using a single channel NaI (Tl) scintillation spectrometer. After making all the necessary corrections, the experimental results were compared with the corresponding theoretical distributions due to the KUB, Lewis and Ford, Nilsson, Ford and Martin and Chang and Falkoff. Also a comparison with those calculated according to Nilsson theory after applying the shape correction factor (M. KUB) was done. The measured spectrum is found to show fairly good agreement with M. KUB theory and is found to deviate thereafter from all five theories. (orig.)

  6. Sample size determination in clinical trials with multiple endpoints

    CERN Document Server

    Sozu, Takashi; Hamasaki, Toshimitsu; Evans, Scott R

    2015-01-01

    This book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area. The determination of sample size and the evaluation of power are fundamental and critical elements in the design of clinical trials. If the sample size is too small, important effects may go unnoticed; if the sample size is too large, it represents a waste of resources and unethically puts more participants at risk than necessary. Recently many clinical trials have been designed with more than one endpoint considered as multiple primary or co-primary, creating a need for new approaches to the design and analysis of these clinical trials. The book focuses on the evaluation of power and sample size determination when comparing the effects of two interventions in superiority clinical trials with multiple endpoints. Methods for sample size calculation in clin...

  7. Calculation of absorbed dose and biological effectiveness from photonuclear reactions in a bremsstrahlung beam of end point 50 MeV.

    Science.gov (United States)

    Gudowska, I; Brahme, A; Andreo, P; Gudowski, W; Kierkegaard, J

    1999-09-01

    The absorbed dose due to photonuclear reactions in soft tissue, lung, breast, adipose tissue and cortical bone has been evaluated for a scanned bremsstrahlung beam of end point 50 MeV from a racetrack accelerator. The Monte Carlo code MCNP4B was used to determine the photon source spectrum from the bremsstrahlung target and to simulate the transport of photons through the treatment head and the patient. Photonuclear particle production in tissue was calculated numerically using the energy distributions of photons derived from the Monte Carlo simulations. The transport of photoneutrons in the patient and the photoneutron absorbed dose to tissue were determined using MCNP4B; the absorbed dose due to charged photonuclear particles was calculated numerically assuming total energy absorption in tissue voxels of 1 cm3. The photonuclear absorbed dose to soft tissue, lung, breast and adipose tissue is about (0.11-0.12)+/-0.05% of the maximum photon dose at a depth of 5.5 cm. The absorbed dose to cortical bone is about 45% larger than that to soft tissue. If the contributions from all photoparticles (n, p, 3He and 4He particles and recoils of the residual nuclei) produced in the soft tissue and the accelerator, and from positron radiation and gammas due to induced radioactivity and excited states of the nuclei, are taken into account the total photonuclear absorbed dose delivered to soft tissue is about 0.15+/-0.08% of the maximum photon dose. It has been estimated that the RBE of the photon beam of 50 MV acceleration potential is approximately 2% higher than that of conventional 60Co radiation.

  8. Calculation of absorbed dose and biological effectiveness from photonuclear reactions in a bremsstrahlung beam of end point 50 MeV

    International Nuclear Information System (INIS)

    Gudowska, I.; Brahme, A.; Andreo, P.; Gudowski, W.; Kierkegaard, J.

    1999-01-01

    The absorbed dose due to photonuclear reactions in soft tissue, lung, breast, adipose tissue and cortical bone has been evaluated for a scanned bremsstrahlung beam of end point 50 MeV from a racetrack accelerator. The Monte Carlo code MCNP4B was used to determine the photon source spectrum from the bremsstrahlung target and to simulate the transport of photons through the treatment head and the patient. Photonuclear particle production in tissue was calculated numerically using the energy distributions of photons derived from the Monte Carlo simulations. The transport of photoneutrons in the patient and the photoneutron absorbed dose to tissue were determined using MCNP4B; the absorbed dose due to charged photonuclear particles was calculated numerically assuming total energy absorption in tissue voxels of 1 cm 3 . The photonuclear absorbed dose to soft tissue, lung, breast and adipose tissue is about (0.11-0.12)±0.05% of the maximum photon dose at a depth of 5.5 cm. The absorbed dose to cortical bone is about 45% larger than that to soft tissue. If the contributions from all photoparticles (n, p, 3 He and 4 He particles and recoils of the residual nuclei) produced in the soft tissue and the accelerator, and from positron radiation and gammas due to induced radioactivity and excited states of the nuclei, are taken into account the total photonuclear absorbed dose delivered to soft tissue is about 0.15±0.08% of the maximum photon dose. It has been estimated that the RBE of the photon beam of 50 MV acceleration potential is approximately 2% higher than that of conventional 60 Co radiation. (author)

  9. Surrogate Endpoint Evaluation: Principal Stratification Criteria and the Prentice Definition.

    Science.gov (United States)

    Gilbert, Peter B; Gabriel, Erin E; Huang, Ying; Chan, Ivan S F

    2015-09-01

    A common problem of interest within a randomized clinical trial is the evaluation of an inexpensive response endpoint as a valid surrogate endpoint for a clinical endpoint, where a chief purpose of a valid surrogate is to provide a way to make correct inferences on clinical treatment effects in future studies without needing to collect the clinical endpoint data. Within the principal stratification framework for addressing this problem based on data from a single randomized clinical efficacy trial, a variety of definitions and criteria for a good surrogate endpoint have been proposed, all based on or closely related to the "principal effects" or "causal effect predictiveness (CEP)" surface. We discuss CEP-based criteria for a useful surrogate endpoint, including (1) the meaning and relative importance of proposed criteria including average causal necessity (ACN), average causal sufficiency (ACS), and large clinical effect modification; (2) the relationship between these criteria and the Prentice definition of a valid surrogate endpoint; and (3) the relationship between these criteria and the consistency criterion (i.e., assurance against the "surrogate paradox"). This includes the result that ACN plus a strong version of ACS generally do not imply the Prentice definition nor the consistency criterion, but they do have these implications in special cases. Moreover, the converse does not hold except in a special case with a binary candidate surrogate. The results highlight that assumptions about the treatment effect on the clinical endpoint before the candidate surrogate is measured are influential for the ability to draw conclusions about the Prentice definition or consistency. In addition, we emphasize that in some scenarios that occur commonly in practice, the principal strata sub-populations for inference are identifiable from the observable data, in which cases the principal stratification framework has relatively high utility for the purpose of effect

  10. Surrogate Endpoint Evaluation: Principal Stratification Criteria and the Prentice Definition

    Science.gov (United States)

    Gilbert, Peter B.; Gabriel, Erin E.; Huang, Ying; Chan, Ivan S.F.

    2015-01-01

    A common problem of interest within a randomized clinical trial is the evaluation of an inexpensive response endpoint as a valid surrogate endpoint for a clinical endpoint, where a chief purpose of a valid surrogate is to provide a way to make correct inferences on clinical treatment effects in future studies without needing to collect the clinical endpoint data. Within the principal stratification framework for addressing this problem based on data from a single randomized clinical efficacy trial, a variety of definitions and criteria for a good surrogate endpoint have been proposed, all based on or closely related to the “principal effects” or “causal effect predictiveness (CEP)” surface. We discuss CEP-based criteria for a useful surrogate endpoint, including (1) the meaning and relative importance of proposed criteria including average causal necessity (ACN), average causal sufficiency (ACS), and large clinical effect modification; (2) the relationship between these criteria and the Prentice definition of a valid surrogate endpoint; and (3) the relationship between these criteria and the consistency criterion (i.e., assurance against the “surrogate paradox”). This includes the result that ACN plus a strong version of ACS generally do not imply the Prentice definition nor the consistency criterion, but they do have these implications in special cases. Moreover, the converse does not hold except in a special case with a binary candidate surrogate. The results highlight that assumptions about the treatment effect on the clinical endpoint before the candidate surrogate is measured are influential for the ability to draw conclusions about the Prentice definition or consistency. In addition, we emphasize that in some scenarios that occur commonly in practice, the principal strata sub-populations for inference are identifiable from the observable data, in which cases the principal stratification framework has relatively high utility for the purpose of

  11. Using a tungsten rollbar to characterize the source spot of a megavoltage bremsstrahlung linac

    International Nuclear Information System (INIS)

    Schach von Wittenau, A.E.; Logan, C.M.; Rikard, R.

    2002-01-01

    In photon teletherapy, the size and functional form of the photon source spot affect both the sharpness of the penumbra of treatment fields and the sharpness of portal images. Photon source spot parameters are also used in photon teletherapy dose calculation codes. A simple method for characterizing the source spot would complement the existing, more involved methods that have been described in the medical physics literature. Such a method, using a rollbar made of tungsten or other high-Z metal, is used in industrial radiography. We describe the use of a tungsten rollbar for characterizing the source spot edge spread function (and thereby the source spot size and shape) of a megavoltage bremsstrahlung photon source. We use Monte Carlo simulations to quantify anticipated experimental artifacts of the method, assuming typical spot sizes for circ-function, Gaussian, and Bennett line shapes. We illustrate the use of the rollbar method by characterizing the source spot of a typical 9 MV linac used for industrial radiography. The source spot is analyzed using two approaches: (a) fitting the rollbar image with analytic functions and (b) using Abel inversion to obtain the cylindrically symmetric spot profile consistent with the measured rollbar image. Monte Carlo simulations, based on a 6 MV photon teletherapy accelerator, suggest that aspects of the method are applicable to medical bremsstrahlung sources

  12. Bremsstrahlung emission coefficient of a plasma in a uniform magnetic field

    International Nuclear Information System (INIS)

    Pangborn, R.J.

    1976-01-01

    The leading (electron-ion, dipole) contribution to the bremsstrahlung spectrum of a Maxwellian plasma in a constant, uniform magnetic field is calculated. The plasma is assumed infinite and fully ionized. A simpler, more direct derivation of Kirchoff's Law for anisotropic media is presented. The plasma dispersion relation is then found using previously obtained expressions for the conductivity tensor (accurate to first order in collisional effects). From the dispersion the collisional damping, assumed small, is obtained and by means of Kirchoff's Law an expression for the bremsstrahlung emission coefficient is written. No terms of order (kappa 2 lambda 2 0 ) or higher are included. For wave frequencies large compared with the plasma and electron cyclotron frequencies (ω 2 much greater than ω 2 rho, ω 2 much greater than Ω 3 ) an expansion of the exact result is given accurate to fourth order in Ω/ω and ω rho/ω. The result is found to disagree with previous high frequency expressions. Analysis of the exact expression reveals that for certain frequencies and directions of propagation the emission spectrum exhibits a resonance quality. The results are presented in such fashion that for various magnetic field strengths the frequency of the resonant emission at arbitrary angle relative to the field is easily obtained. These phenomena arise due to the influence of the magnetic fieldon the dielectric properties of the plasma and not because of its effect on the binary collision process. A physical explanation of the results is presented

  13. 'Atomic Bremsstrahlung': Retrospectives, current status and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Amusia, M.Ya. [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel) and Ioffe Physical-Technical Institute, St. Petersburg 194021 (Russian Federation)]. E-mail: Amusia@vms.huji.ac.il

    2006-10-15

    We describe here the 'Atomic bremsstrahlung' (AB)-emission of continuous spectrum electromagnetic radiation, which is generated in collisions of particles that have internal deformable structure that includes positively and negatively charged constituents. The deformation of one or both colliding partners induces multiple, mainly dipole, time-dependent electrical moments that become a source of radiation. The history of AB invention is presented and its unusual in comparison to ordinary bremsstrahlung (OB) properties, are discussed. As examples, fast electron atom, non-relativistic and relativistic collisions are considered. Attention is given to ion-atom and atom-atom collisions. Specifics of 'elastic' and 'inelastic' (i.e. radiation accompanied by destruction of collision partners) AB will be mentioned. Attention will be given to possible manifestation of AB in nature and in some exotic systems, for instance scattering of electrons upon muonic hydrogen. Some cooperative effects connected to AB will be considered. New classical schemes similar to AB will be presented.

  14. Sensitivity of submersed freshwater macrophytes and endpoints in laboratory toxicity tests

    International Nuclear Information System (INIS)

    Arts, Gertie H.P.; Belgers, J. Dick M.; Hoekzema, Conny H.; Thissen, Jac T.N.M.

    2008-01-01

    The toxicological sensitivity and variability of a range of macrophyte endpoints were statistically tested with data from chronic, non-axenic, macrophyte toxicity tests. Five submersed freshwater macrophytes, four pesticides/biocides and 13 endpoints were included in the statistical analyses. Root endpoints, reflecting root growth, were most sensitive in the toxicity tests, while endpoints relating to biomass, growth and shoot length were less sensitive. The endpoints with the lowest coefficients of variation were not necessarily the endpoints, which were toxicologically most sensitive. Differences in sensitivity were in the range of 10-1000 for different macrophyte-specific endpoints. No macrophyte species was consistently the most sensitive. Criteria to select endpoints in macrophyte toxicity tests should include toxicological sensitivity, variance and ecological relevance. Hence, macrophyte toxicity tests should comprise an array of endpoints, including very sensitive endpoints like those relating to root growth. - A range of endpoints is more representative of macrophyte fitness than biomass and growth only

  15. Electron bremsstrahlung in collisions of 223 MeV/u He-like uranium ions with gaseous targets

    Energy Technology Data Exchange (ETDEWEB)

    Ludziejewski, T.; Beyer, H.; Bosch, F.; Brinzanescu, O.; Franzke, B.; Kozhuharov, C.; Liesen, D.; Menzel, G.; Meier, J.; Mokler, P.H.; Reich, H.; Steck, M.; Stenner, L. [Gesellschaft fuer Schwerionenforschung, D-64220 Darmstadt (Germany); Stoehlker, Th. [University of Frankfurt, D-60486 Frankfurt (Germany); Gesellschaft fuer Schwerionenforschung, D-64220 Darmstadt (Germany); Keller, S. [University of Frankfurt, D-60054 Frankfurt (Germany); Dunford, R.W. [Argonne National Laboratory, Argonne, IL 60439 (United States); Livingston, A.E. [University of Notre Dame, Indiana 4556 (United States); Rymuza, P. [Institute for Nuclear Studies, 05-400 Swierk (Poland); Stachura, Z. [Institute of Nuclear Physics, 31-342 Cracow (Poland); Swiat, P.; Warczak, A. [Jagiellonian University, 30-059 Cracow (Poland)

    1998-06-14

    The bremsstrahlung process in the domain of strong Coulomb fields has been investigated for N{sub 2} and Ar target electrons colliding with He-like uranium ions at 223 MeV/u. The differential cross sections for bremsstrahlung were measured at laboratory observation angles of 48 deg., 90 deg., and 132 deg. Substantial discrepancies were found between the experimental cross sections and the first-order Born approximation calculations. The reported data provide a new testing ground for non-perturbative treatment of the coupling between radiation and matter in the presence of strong fields. (author)

  16. Electron bremsstrahlung in collisions of 223 MeV/u He-like uranium ions with gaseous targets

    International Nuclear Information System (INIS)

    Ludziejewski, T.; Beyer, H.; Bosch, F.; Brinzanescu, O.; Franzke, B.; Kozhuharov, C.; Liesen, D.; Menzel, G.; Meier, J.; Mokler, P.H.; Reich, H.; Steck, M.; Stenner, L.; Stoehlker, T.; Keller, S.; Dunford, R.W.; Livingston, A.E.; Rymuza, P.; Stachura, Z.; Swiat, P.; Warczak, A.

    1997-09-01

    The bremsstrahlung process in the domain of strong Coulomb fields has been investigated for N 2 and Ar target electrons colliding with He-like uranium ions at 223 MeV/u. The doubly differential cross sections for bremsstrahlung were measured at the laboratory observation angles of 48 , 90 , and 132 . Substantial discrepancies were found between the experimental cross secions and the first order Born approximation calculations. The reported data provide a new testing ground for non-perturbative treatment of the coupling between radiation and matter in the presence of strong fields. (orig.)

  17. Electron bremsstrahlung in collisions of 223 MeV/u He-like uranium ions with gaseous targets

    Energy Technology Data Exchange (ETDEWEB)

    Ludziejewski, T.; Beyer, H.; Bosch, F.; Brinzanescu, O.; Franzke, B.; Kozhuharov, C.; Liesen, D.; Menzel, G.; Meier, J.; Mokler, P.H.; Reich, H.; Steck, M.; Stenner, L. [Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany); Stoehlker, T. [Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany)]|[Frankfurt Univ. (Germany); Keller, S. [Frankfurt Univ. (Germany); Dunford, R.W. [Argonne National Lab., IL (United States); Livingston, A.E. [Notre Dame Univ., IN (United States); Rymuza, P. [Institute for Nuclear Studies, Swierk (Poland); Stachura, Z. [Henryk Niewodniczanski Inst. of Nuclear Physics, Cracow (Poland); Swiat, P.; Warczak, A. [Jagiellonian Univ., Krakow (Poland)

    1997-09-01

    The bremsstrahlung process in the domain of strong Coulomb fields has been investigated for N{sub 2} and Ar target electrons colliding with He-like uranium ions at 223 MeV/u. The doubly differential cross sections for bremsstrahlung were measured at the laboratory observation angles of 48 , 90 , and 132 . Substantial discrepancies were found between the experimental cross secions and the first order Born approximation calculations. The reported data provide a new testing ground for non-perturbative treatment of the coupling between radiation and matter in the presence of strong fields. (orig.) 35 refs.

  18. Study of bremsstrahlung dose fields in radiation shield and labyrinth devices of plants with LUEH-8/5B accelerator

    International Nuclear Information System (INIS)

    Vikulin, A.A.; Vanyushkin, B.M.; Garnyk, D.V.; Kon'kov, N.G.; Terent'ev, B.M.

    1980-01-01

    Measurement results of exposure dose rate (EDR) of radiation in fields of bremsstrahlung of radiation plants with LUEh-8/5B linear accelerator of electrons by means of DRG2-03 dose meter, intended for operative measuring EDR in high intense fields of γ-radiation of powerful radioisotopic plants, are presented. Dose meter design is described. Measurements of bremsstrahlung EDR have been carried out in the chamber of plant irradiation for radiation sterilizing medical items, as well as in the chamber of VNIIRT experimental plant. RUP-1 device has been used for measuring radiation EDR in a labyrinth behind 1.8 m thick shoulder by concrete [ru

  19. Electroweak one-loop corrections for e+e- annihilation into t anti t including hard bremsstrahlung

    International Nuclear Information System (INIS)

    Fleischer, J.; Leike, A.; Riemann, T.; Werthenbach, A.

    2003-01-01

    We present the complete electroweak one-loop corrections to top-pair production at a linear e + e - collider in the continuum region. Besides weak and photonic virtual corrections, real hard bremsstrahlung with simple realistic kinematical cuts is included. For the bremsstrahlung we advocate a semi-analytical approach with a high numerical accuracy. The virtual corrections are parameterized through six independent form factors, suitable for Monte Carlo implementation. Alternatively, our numerical package Topfit, a stand-alone code, can be utilized for the calculation of both differential and integrated cross sections as well as forward-backward asymmetries. (orig.)

  20. Estimation of Electron Dose Delivered by a 0.4 MeV Accelerator from Bremsstrahlung Dose Measurements

    DEFF Research Database (Denmark)

    Karadjov, A. G.; Hansen, Jørgen-Walther

    1980-01-01

    Determination of a 0.4 MeV electron dose from a bremsstrahlung dose measurement using a converter-detector system is considered. The detector used is a Frickle dosimeter, and the converters are aluminum, copper and lead foils. Optimal converter thickness is ascertained experimentally for each mat...... materials within a Z-range of 13–82. A linear relation is found between bremsstrahlung dose and electron dose ranging from 2 to 20 Mrad. Finally the effect of converter area on detector response is studied....

  1. Production of high energy photon beam at TAC

    International Nuclear Information System (INIS)

    Akkurt, I.; Tekin, H. O.; Demir, N.; Cakirli, R. B.; Akkus, B.; Kupa, I.

    2010-01-01

    When an electron pass through an electric field, the electron loose its part of energy and photon is generated. This process is known as Bremsstrahlung (means 'radiation breaking' in German) and this photon can be used in a variety of different application. The TAC will be first Turkish Accelerator Center (TAC) where a IR-FEL and Beamstrahlung photon beam facilities will be established in first stage. The electrons will be accelerated up to 40 MeV by two LINAC and these beam will be used to generate Bremsstrahlung photon. In this study, the main parameters for Bremsstrahlung photon beam facility will be established at TAC will be detailed and fields to be used Bremsstrahlung beam will also be presented.

  2. The Asthma Control Questionnaire as a clinical trial endpoint

    DEFF Research Database (Denmark)

    Barnes, P J; Casale, T B; Dahl, Ronald

    2014-01-01

    these component endpoints; however, there is no consensus on the optimal instrument for use in clinical trials. The Asthma Control Questionnaire (ACQ) has been shown to be a valid, reliable instrument that allows accurate and reproducible assessment of asthma control that compares favourably with other commonly...

  3. Biomechanical constraints on the feedforward regulation of endpoint stiffness.

    Science.gov (United States)

    Hu, Xiao; Murray, Wendy M; Perreault, Eric J

    2012-10-01

    Although many daily tasks tend to destabilize arm posture, it is still possible to have stable interactions with the environment by regulating the multijoint mechanics of the arm in a task-appropriate manner. For postural tasks, this regulation involves the appropriate control of endpoint stiffness, which represents the stiffness of the arm at the hand. Although experimental studies have been used to evaluate endpoint stiffness control, including the orientation of maximal stiffness, the underlying neural strategies remain unknown. Specifically, the relative importance of feedforward and feedback mechanisms has yet to be determined due to the difficulty separately identifying the contributions of these mechanisms in human experiments. This study used a previously validated three-dimensional musculoskeletal model of the arm to quantify the degree to which the orientation of maximal endpoint stiffness could be changed using only steady-state muscle activations, used to represent feedforward motor commands. Our hypothesis was that the feedforward control of endpoint stiffness orientation would be significantly constrained by the biomechanical properties of the musculoskeletal system. Our results supported this hypothesis, demonstrating substantial biomechanical constraints on the ability to regulate endpoint stiffness throughout the workspace. The ability to regulate stiffness orientation was further constrained by additional task requirements, such as the need to support the arm against gravity or exert forces on the environment. Together, these results bound the degree to which slowly varying feedforward motor commands can be used to regulate the orientation of maximum arm stiffness and provide a context for better understanding conditions in which feedback control may be needed.

  4. Modeling hard clinical end-point data in economic analyses.

    Science.gov (United States)

    Kansal, Anuraag R; Zheng, Ying; Palencia, Roberto; Ruffolo, Antonio; Hass, Bastian; Sorensen, Sonja V

    2013-11-01

    The availability of hard clinical end-point data, such as that on cardiovascular (CV) events among patients with type 2 diabetes mellitus, is increasing, and as a result there is growing interest in using hard end-point data of this type in economic analyses. This study investigated published approaches for modeling hard end-points from clinical trials and evaluated their applicability in health economic models with different disease features. A review of cost-effectiveness models of interventions in clinically significant therapeutic areas (CV diseases, cancer, and chronic lower respiratory diseases) was conducted in PubMed and Embase using a defined search strategy. Only studies integrating hard end-point data from randomized clinical trials were considered. For each study included, clinical input characteristics and modeling approach were summarized and evaluated. A total of 33 articles (23 CV, eight cancer, two respiratory) were accepted for detailed analysis. Decision trees, Markov models, discrete event simulations, and hybrids were used. Event rates were incorporated either as constant rates, time-dependent risks, or risk equations based on patient characteristics. Risks dependent on time and/or patient characteristics were used where major event rates were >1%/year in models with fewer health states (Models of infrequent events or with numerous health states generally preferred constant event rates. The detailed modeling information and terminology varied, sometimes requiring interpretation. Key considerations for cost-effectiveness models incorporating hard end-point data include the frequency and characteristics of the relevant clinical events and how the trial data is reported. When event risk is low, simplification of both the model structure and event rate modeling is recommended. When event risk is common, such as in high risk populations, more detailed modeling approaches, including individual simulations or explicitly time-dependent event rates, are

  5. Diagnostics of pre-breakdown light emission in a helium coplanar barrier discharge: the presence of neutral bremsstrahlung

    Czech Academy of Sciences Publication Activity Database

    Navrátil, Z.; Morávek, T.; Ráhel’, J.; Čech, J.; Lalinský, Ondřej; Trunec, D.

    2017-01-01

    Roč. 26, č. 5 (2017), s. 1-10, č. článku 055025. ISSN 0963-0252 Institutional support: RVO:68081731 Keywords : dielectric barrier discharge * helium * single photon counting * bremsstrahlung * electric field * backward discharge * surface charge Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering OBOR OECD: Fluids and plasma physics (including surface physics) Impact factor: 3.302, year: 2016

  6. Patients’ preferences for selection of endpoints in cardiovascular clinical trials

    Directory of Open Access Journals (Sweden)

    Robert D. Chow

    2014-02-01

    Full Text Available Background: To reduce the duration and overall costs of cardiovascular trials, use of the combined endpoints in trial design has become commonplace. Though this methodology may serve the needs of investigators and trial sponsors, the preferences of patients or potential trial subjects in the trial design process has not been studied. Objective: To determine the preferences of patients in the design of cardiovascular trials. Design: Participants were surveyed in a pilot study regarding preferences among various single endpoints commonly used in cardiovascular trials, preference for single vs. composite endpoints, and the likelihood of compliance with a heart medication if patients similar to them participated in the trial design process. Participants: One hundred adult English-speaking patients, 38% male, from a primary care ambulatory practice located in an urban setting. Key results: Among single endpoints, participants rated heart attack as significantly more important than death from other causes (4.53 vs. 3.69, p=0.004 on a scale of 1–6. Death from heart disease was rated as significantly more important than chest pain (4.73 vs. 2.47, p<0.001, angioplasty/PCI/CABG (4.73 vs. 2.43, p<0.001, and stroke (4.73 vs. 2.43, p<0.001. Participants also expressed a slight preference for combined endpoints over single endpoint (43% vs. 57%, incorporation of the opinions of the study patient population into the design of trials (48% vs. 41% for researchers, and a greater likelihood of medication compliance if patient preferences were considered during trial design (67% indicated a significant to major effect. Conclusions: Patients are able to make judgments and express preferences regarding trial design. They prefer that the opinions of the study population rather than the general population be incorporated into the design of the study. This novel approach to study design would not only incorporate patient preferences into medical decision making, but

  7. Polarization bremsstrahlung of a hydrogen-like ion in a single crystal

    International Nuclear Information System (INIS)

    Astapenko, V. A.

    2009-01-01

    Polarization bremsstrahlung (PB) that arises when a fast hydrogen-like ion is scattered in a single crystal is investigated theoretically. Four types of the process are analyzed that are caused by virtual excitation of electrons of the target and of the incident particle (IP), as well as by a coherent and incoherent interaction between the IP and the single crystal. The spectral, angular, and velocity (of the IP) characteristics of PB are calculated with regard to the spectral function of a photodetector. Optimal observation conditions and regions in which different types of PB are dominant are determined, and the dependence of these regions on the charge of the IP nucleus and of the target atoms is revealed

  8. Spin dynamics of electrons in strong fields studied via bremsstrahlung from a polarized electron beam

    Energy Technology Data Exchange (ETDEWEB)

    Tashenov, Stanislav [Royal Institute of Technology, Stockholm (Sweden); Stockholm University (Sweden); Physikalisches Institut, Universitaet Heidelberg (Germany); Baeck, Torbjoern; Cederwall, Bo; Khaplanov, Anton; Schaessburger, Kai-Uwe [Royal Institute of Technology, Stockholm (Sweden); Barday, Roman; Enders, Joachim; Poltoratska, Yuliya [Institut fuer Kernphysik, Technische Universitaet, Darmstadt (Germany); Surzhykov, Andrey [Physikalisches Institut, Universitaet Heidelberg (Germany); GSI, Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany)

    2011-07-01

    Linear polarization of the photons emitted in the process of the atomic field electron bremsstrahlung has been studied at the newly developed 100 keV polarized electron source of TU Darmstadt. A correlation between the initial orientation of the electron spin and the degree and the angle of photon linear polarization has been measured for the first time. For this purpose a hard x-ray Compton polarimeter consisting of a segmented high purity germanium detector and an external passive photon scattering target have been applied. Linear polarization sensitive Compton and Rayleigh photon scattering distributions have been sampled by the segmented detector. The observed polarization correlation reveals a precession of the electron spin as it moves in the field of the nucleus. The full-relativistic calculations for the case of radiative recombination into a Rydberg series limit have been corroborated by the measurement. The results of this experiment suggest a new method for electron beam polarimetry.

  9. Investigation of singularities of integral intensity of the relativistic particle bremsstrahlung radiation in a diamond crystal

    International Nuclear Information System (INIS)

    Avakyan, R.O.; Armaganyan, A.A.; Arutyunyan, L.G.; Iskandaryan, A.G.; Taroyan, S.P.

    1981-01-01

    The results are given of the theoretical processing of experimental data on the investigation of orientational dependences of integral intensity of coherent bremsstrahlung radiation (CBR) of superfast electrons in a diamond crystal. It is shown that in the case of ''point effect'' right up to the electrons incident angle, which is 0.1 mrad with respect to the crystallographic plane, the CBR theory gives a good description of experimental data. In the case of ''row effect'', in order to account for the divergence between the theory and experiment at small incident angles of electrons with respect to the crystallographic axis, it is assumed that the multiple scattering angle has an orientational dependence. By fitting the theoretical curve to experimental points the dependences are obtained of the multiple scattering angle change on the crystal orientation with respect to the electron beam

  10. BPS Wilson loops and Bremsstrahlung function in ABJ(M): a two loop analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bianchi, Marco S. [Institut für Physik, Humboldt-Universität zu Berlin,Newtonstraße 15, 12489 Berlin (Germany); Griguolo, Luca [Dipartimento di Fisica e Scienze della Terra, Università di Parmaand INFN Gruppo Collegato di Parma,Viale G.P. Usberti 7/A, 43100 Parma (Italy); Leoni, Matias [Physics Department, FCEyN-UBA & IFIBA-CONICETCiudad Universitaria, Pabellón I, 1428, Buenos Aires (Argentina); Penati, Silvia [Dipartimento di Fisica, Università di Milano-Bicoccaand INFN, Sezione di Milano-Bicocca,Piazza della Scienza 3, I-20126 Milano (Italy); Seminara, Domenico [Dipartimento di Fisica, Università di Firenzeand INFN Sezione di Firenze,via G. Sansone 1, 50019 Sesto Fiorentino (Italy)

    2014-06-19

    We study a family of circular BPS Wilson loops in N=6 super Chern-Simons-matter theories, generalizing the usual 1/2-BPS circle. The scalar and fermionic couplings depend on two deformation parameters and these operators can be considered as the ABJ(M) counterpart of the DGRT latitudes defined in N=4 SYM. We perform a complete two-loop analysis of their vacuum expectation value, discuss the appearance of framing-like phases and propose a general relation with cohomologically equivalent bosonic operators. We make an all-loop proposal for computing the Bremsstrahlung function associated to the 1/2-BPS cusp in terms of these generalized Wilson loops. When applied to our two-loop result it reproduces the known expression. Finally, we comment on the generalization of this proposal to the bosonic 1/6-BPS case.

  11. Sterilization of health care products by 5 MeV bremsstrahlung (X ray)

    International Nuclear Information System (INIS)

    Sato, Yoshishige; Takahashi, Thoru; Saito, Toshio; Sato, Toshio; Takehisa, Masaaki

    1993-01-01

    Radiation sensitivities of B. pumilis and B. subtilis spores were examined to bremsstrahlung of 5 MeV EB and Cobalt-60 γ rays in order to confirm the effects of radiation and dose rate. Biological indicators were irradiated with the X rays in the dose rate range of 4.7-47 kGy/h. D-value of B. pumilis spores was 1.4-1.5 kGy, and that of B. subtilis was 1.1-1.3 kGy. The D-values of B. pumilus and B. subtilis have very small dose rate dependences to X ray, and the D-values are similar to those of γ rays. Dose distribution by X-ray and γ irradiation was measured for cartons containing 32 unit dialyzers. The D max. /D min. of the X-ray irradiation (1.2) was smaller than that of γ ray (1.3). (author)

  12. Studies on inner bremsstrahlung from a few β-emitting isotopes

    International Nuclear Information System (INIS)

    Keshava, S.L.; Gopala, K.; Venkataramaiah, P.

    2000-01-01

    Past experimental studies on the inner bremsstrahlung (IB) emission from the forbidden β transitions have shown marked deviations from the theoretical calculations of Lewis and Ford, Ford and Martin, Chang and Falkoff, Madansky and Gebhardt. In this paper we have re-analysed the data of IB emissions from four β-emitting isotopes, namely 89 Sr, 141 Ce, 111 Ag and 99 Tc, whose transitions are classified as forbidden. The raw experimental data already available in the literature are critically examined in the light of relevant statistics in order to arrive at meaningful conclusions. The unfolding of the IB spectra was done following the step-by-step procedure of Liden and Starfelt. The results obtained were different from those reported in the literature. (author)

  13. Inner Bremsstrahlung accompanying the non-unique first forbidden β-decay of 141Ce

    International Nuclear Information System (INIS)

    Khalil, E.I.

    1993-01-01

    The inner Bremsstrahlung (I.B.) spectrum accompanying the β-decay of 141 Ce (non-unique first forbidden β-transition) was measured using a single channel scintillation spectrometer. The measured I.B. was analyzed by the variable width peeling-off method. This analyzed and corrected I.B. was compared with those calculated according to the original theories of Knipp and Uhlenbeck as well as of Bloch (KUB), the coulomb corrected theories of Lewis and Ford and of Nilsson, and according to detour-transition calculations of the Ford and Martin theory. Ths shape correction factor suggested by Konopinski and Uhlenbeck on the Fermi β-decay theory was applied to the calculated I.B. based on Nilsson's theory (modified KUB theory). The experimental results are in better agreement with the modified KUB theory than the other theories. (orig.)

  14. Trial endpoints for drug approval in oncology: Chemoprevention.

    Science.gov (United States)

    Beitz, J

    2001-04-01

    As with other drugs, new drug applications for marketing approval of chemopreventive drugs must include data from adequate and well-controlled clinical trials that demonstrate effectiveness and safety for the intended use. This article summarizes the regulatory requirements for traditional marketing approval, as well as for approval under the accelerated approval regulations. Unlike traditional approval, accelerated approval is based on a surrogate endpoint that is reasonably likely to predict clinical benefit. Discussions with the Food and Drug Administration (FDA) regarding the validity of trial endpoints that may serve as surrogates for clinical benefit for accelerated approval should take place as early as possible in drug development. Meetings with the FDA to discuss these issues may be requested throughout the clinical development of a new drug.

  15. Sperm count as a surrogate endpoint for male fertility control.

    Science.gov (United States)

    Benda, Norbert; Gerlinger, Christoph

    2007-11-30

    When assessing the effectiveness of a hormonal method of fertility control in men, the classical approach used for the assessment of hormonal contraceptives in women, by estimating the pregnancy rate or using a life-table analysis for the time to pregnancy, is difficult to apply in a clinical development program. The main reasons are the dissociation of the treated unit, i.e. the man, and the observed unit, i.e. his female partner, the high variability in the frequency of male intercourse, the logistical cost and ethical concerns related to the monitoring of the trial. A reasonable surrogate endpoint of the definite endpoint time to pregnancy is sperm count. In addition to the avoidance of the mentioned problems, trials that compare different treatments are possible with reasonable sample sizes, and study duration can be shorter. However, current products do not suppress sperm production to 100 per cent in all men and the sperm count is only observed with measurement error. Complete azoospermia might not be necessary in order to achieve an acceptable failure rate compared with other forms of male fertility control. Therefore, the use of sperm count as a surrogate endpoint must rely on the results of a previous trial in which both the definitive- and surrogate-endpoint results were assessed. The paper discusses different estimation functions of the mean pregnancy rate (corresponding to the cumulative hazard) that are based on the results of sperm count trial and a previous trial in which both sperm count and time to pregnancy were assessed, as well as the underlying assumptions. Sample size estimations are given for pregnancy rate estimation with a given precision.

  16. Gene expression profiling reveals multiple toxicity endpoints induced by hepatotoxicants

    Energy Technology Data Exchange (ETDEWEB)

    Huang Qihong; Jin Xidong; Gaillard, Elias T.; Knight, Brian L.; Pack, Franklin D.; Stoltz, James H.; Jayadev, Supriya; Blanchard, Kerry T

    2004-05-18

    Microarray technology continues to gain increased acceptance in the drug development process, particularly at the stage of toxicology and safety assessment. In the current study, microarrays were used to investigate gene expression changes associated with hepatotoxicity, the most commonly reported clinical liability with pharmaceutical agents. Acetaminophen, methotrexate, methapyrilene, furan and phenytoin were used as benchmark compounds capable of inducing specific but different types of hepatotoxicity. The goal of the work was to define gene expression profiles capable of distinguishing the different subtypes of hepatotoxicity. Sprague-Dawley rats were orally dosed with acetaminophen (single dose, 4500 mg/kg for 6, 24 and 72 h), methotrexate (1 mg/kg per day for 1, 7 and 14 days), methapyrilene (100 mg/kg per day for 3 and 7 days), furan (40 mg/kg per day for 1, 3, 7 and 14 days) or phenytoin (300 mg/kg per day for 14 days). Hepatic gene expression was assessed using toxicology-specific gene arrays containing 684 target genes or expressed sequence tags (ESTs). Principal component analysis (PCA) of gene expression data was able to provide a clear distinction of each compound, suggesting that gene expression data can be used to discern different hepatotoxic agents and toxicity endpoints. Gene expression data were applied to the multiplicity-adjusted permutation test and significantly changed genes were categorized and correlated to hepatotoxic endpoints. Repression of enzymes involved in lipid oxidation (acyl-CoA dehydrogenase, medium chain, enoyl CoA hydratase, very long-chain acyl-CoA synthetase) were associated with microvesicular lipidosis. Likewise, subsets of genes associated with hepatotocellular necrosis, inflammation, hepatitis, bile duct hyperplasia and fibrosis have been identified. The current study illustrates that expression profiling can be used to: (1) distinguish different hepatotoxic endpoints; (2) predict the development of toxic endpoints; and

  17. Pulmonary Endpoints in Duchenne Muscular Dystrophy. A Workshop Summary.

    Science.gov (United States)

    Finder, Jonathan; Mayer, Oscar Henry; Sheehan, Daniel; Sawnani, Hemant; Abresch, R Ted; Benditt, Joshua; Birnkrant, David J; Duong, Tina; Henricson, Erik; Kinnett, Kathi; McDonald, Craig M; Connolly, Anne M

    2017-08-15

    Development of novel therapeutics for treatment of Duchenne muscular dystrophy (DMD) has led to clinical trials that include pulmonary endpoints that allow assessment of respiratory muscle status, especially in nonambulatory subjects. Parent Project Muscular Dystrophy (PPMD) convened a workshop in Bethesda, Maryland, on April 14 and 15, 2016, to summarize published respiratory data in DMD and give guidance to clinical researchers assessing the effect of interventions on pulmonary outcomes in DMD.

  18. Photospallation reactions of 133Cs and 139La by 100 MeV- and 200 MeV bremsstrahlungs

    International Nuclear Information System (INIS)

    Sakamoto, K.; Toramoto, H.; Hamajima, Y.; Okada, K.; Dohniwa, M.

    1984-01-01

    Spallation yields relative to the 196 Au yield from 197 Au(γ,n) of 26 to 46 nuclides of Sb, Te, I, Xe, Cs and/or Ba and La from 133 Cs and 139 La targets irradiated with bremsstrahlungs of end energies of 100 MeV and 200 MeV were radiochemically determined. The isomeric yield ratios for 132 La and 131 Ba from the ( 139 La + 100 MeV-γ), 132 La, 131 Ba, 121 Te and 119 Te from the ( 139 La + 200 MeV-γ, and 120 I, 121 Te and 119 Te from the ( 133 Cs +- 200 MeV-γ) were also determined. The isotopic yields from the (γ,yn) reactions decrease exponentially with increase of y up to 5, and show no dependence on energy and targets studied, indicating that the reactions of a few neutron emissions occur at energies lower than 100 MeV. When the product yields from the (γ,xpyn) reactions were plotted against (x + y) for each x (isotopic distribution), a regular variation of the Gaussian distributions, typical of nuclear spallation, was observed. Isobaric mass distributions and charge dispersions were deduced to extract characteristic features of these reactions. The isobaric distributions due only to photons of 100 MeV to 200 MeV, which were obtained by subtracting the 100 MeV-yields from the 200 MeV-yields, are very close to a symmetric one peaking at about 8 amu from the target masses. Nuclear charges are also dispersed symmetrically, with most probable N/Zsub(p) of about 1.3 replaced by about 1 amu to the neutron-deficient side from the beta stability valley in all the cases studied. Parameters included in Rudstam's semi-empirical formula were examined by comparing with the observed yield curves. The P values of 0.45 and 0.65, chosen for a better fit to the 200 MeV data on 133 Cs and 139 La, respectively, were larger than the predictions reported in the literature. The magic number effects of 139 La may explain the target-differences in mass distributions. (orig.)

  19. Exposing the cancer genome atlas as a SPARQL endpoint

    Science.gov (United States)

    Deus, Helena F.; Veiga, Diogo F.; Freire, Pablo R.; Weinstein, John N.; Mills, Gordon B.; Almeida, Jonas S.

    2011-01-01

    The Cancer Genome Atlas (TCGA) is a multidisciplinary, multi-institutional effort to characterize several types of cancer. Datasets from biomedical domains such as TCGA present a particularly challenging task for those interested in dynamically aggregating its results because the data sources are typically both heterogeneous and distributed. The Linked Data best practices offer a solution to integrate and discover data with those characteristics, namely through exposure of data as Web services supporting SPARQL, the Resource Description Framework query language. Most SPARQL endpoints, however, cannot easily be queried by data experts. Furthermore, exposing experimental data as SPARQL endpoints remains a challenging task because, in most cases, data must first be converted to Resource Description Framework triples. In line with those requirements, we have developed an infrastructure to expose clinical, demographic and molecular data elements generated by TCGA as a SPARQL endpoint by assigning elements to entities of the Simple Sloppy Semantic Database (S3DB) management model. All components of the infrastructure are available as independent Representational State Transfer (REST) Web services to encourage reusability, and a simple interface was developed to automatically assemble SPARQL queries by navigating a representation of the TCGA domain. A key feature of the proposed solution that greatly facilitates assembly of SPARQL queries is the distinction between the TCGA domain descriptors and data elements. Furthermore, the use of the S3DB management model as a mediator enables queries to both public and protected data without the need for prior submission to a single data source. PMID:20851208

  20. Overview of Biomarkers and Surrogate Endpoints in Drug Development

    Directory of Open Access Journals (Sweden)

    John A. Wagner

    2002-01-01

    Full Text Available There are numerous factors that recommend the use of biomarkers in drug development including the ability to provide a rational basis for selection of lead compounds, as an aid in determining or refining mechanism of action or pathophysiology, and the ability to work towards qualification and use of a biomarker as a surrogate endpoint. Examples of biomarkers come from many different means of clinical and laboratory measurement. Total cholesterol is an example of a clinically useful biomarker that was successfully qualified for use as a surrogate endpoint. Biomarkers require validation in most circumstances. Validation of biomarker assays is a necessary component to delivery of high-quality research data necessary for effective use of biomarkers. Qualification is necessary for use of a biomarker as a surrogate endpoint. Putative biomarkers are typically identified because of a relationship to known or hypothetical steps in a pathophysiologic cascade. Biomarker discovery can also be effected by expression profiling experiment using a variety of array technologies and related methods. For example, expression profiling experiments enabled the discovery of adipocyte related complement protein of 30 kD (Acrp30 or adiponectin as a biomarker for in vivo activation of peroxisome proliferator-activated receptors (PPAR γ activity.

  1. Congenital Adrenal Hyperplasia: Classification of Studies Employing Psychological Endpoints

    Directory of Open Access Journals (Sweden)

    Sandberg DavidE

    2010-08-01

    Full Text Available Psychological outcomes in persons with congenital adrenal hyperplasia (CAH have received substantial attention. The objectives of this paper were to (1 catalog psychological endpoints assessed in CAH outcome studies and (2 classify the conceptual/theoretical model shaping the research design and interpretation of CAH-related psychological effects. A total of 98 original research studies, published between 1955 and 2009, were categorized based on psychological endpoints examined as well as the research design and conceptual model guiding analysis and interpretation of data. The majority of studies (68% investigated endpoints related to psychosexual differentiation. The preponderance of studies (76% examined a direct relationship (i.e., inferring causality between prenatal androgen exposure and psychological outcomes. Findings are discussed in relation to the observed imbalance between theoretical interest in the role of prenatal androgens in shaping psychosexual differentiation and a broader conceptual model that examines the role of other potential factors in mediating or moderating the influence of CAH pathophysiology on psychological outcomes in both affected females and males. The latter approach offers to identify factors amenable to clinical intervention that enhance both health and quality of life outcomes in CAH as well as other disorders of sex development.

  2. Direct measurement of the partial decay energy of 7Be inner bremstrahlung spectrum

    International Nuclear Information System (INIS)

    Sanjeeviah, H.; Sanjeeviah, B.

    1978-01-01

    The inner bremsstrahlung spectrum accompanying orbital electron capture decay of 7 Be to the first excited state of 7 Li was measured in coincidence with 477 keV gamma rays. From the Jauch plot of the spectrum the partial decay energy was found to be 394 +- 16 keV. The shape factor of the inner bremsstrahlung spectrum close to the end point was accurately determined. It was found to be a constant X(1.001 +- 0.002) (author)

  3. Exposing the cancer genome atlas as a SPARQL endpoint.

    Science.gov (United States)

    Deus, Helena F; Veiga, Diogo F; Freire, Pablo R; Weinstein, John N; Mills, Gordon B; Almeida, Jonas S

    2010-12-01

    The Cancer Genome Atlas (TCGA) is a multidisciplinary, multi-institutional effort to characterize several types of cancer. Datasets from biomedical domains such as TCGA present a particularly challenging task for those interested in dynamically aggregating its results because the data sources are typically both heterogeneous and distributed. The Linked Data best practices offer a solution to integrate and discover data with those characteristics, namely through exposure of data as Web services supporting SPARQL, the Resource Description Framework query language. Most SPARQL endpoints, however, cannot easily be queried by data experts. Furthermore, exposing experimental data as SPARQL endpoints remains a challenging task because, in most cases, data must first be converted to Resource Description Framework triples. In line with those requirements, we have developed an infrastructure to expose clinical, demographic and molecular data elements generated by TCGA as a SPARQL endpoint by assigning elements to entities of the Simple Sloppy Semantic Database (S3DB) management model. All components of the infrastructure are available as independent Representational State Transfer (REST) Web services to encourage reusability, and a simple interface was developed to automatically assemble SPARQL queries by navigating a representation of the TCGA domain. A key feature of the proposed solution that greatly facilitates assembly of SPARQL queries is the distinction between the TCGA domain descriptors and data elements. Furthermore, the use of the S3DB management model as a mediator enables queries to both public and protected data without the need for prior submission to a single data source. Copyright © 2010 Elsevier Inc. All rights reserved.

  4. Two-temperature LATE-PCR endpoint genotyping

    Directory of Open Access Journals (Sweden)

    Reis Arthur H

    2006-12-01

    Full Text Available Abstract Background In conventional PCR, total amplicon yield becomes independent of starting template number as amplification reaches plateau and varies significantly among replicate reactions. This paper describes a strategy for reconfiguring PCR so that the signal intensity of a single fluorescent detection probe after PCR thermal cycling reflects genomic composition. The resulting method corrects for product yield variations among replicate amplification reactions, permits resolution of homozygous and heterozygous genotypes based on endpoint fluorescence signal intensities, and readily identifies imbalanced allele ratios equivalent to those arising from gene/chromosomal duplications. Furthermore, the use of only a single colored probe for genotyping enhances the multiplex detection capacity of the assay. Results Two-Temperature LATE-PCR endpoint genotyping combines Linear-After-The-Exponential (LATE-PCR (an advanced form of asymmetric PCR that efficiently generates single-stranded DNA and mismatch-tolerant probes capable of detecting allele-specific targets at high temperature and total single-stranded amplicons at a lower temperature in the same reaction. The method is demonstrated here for genotyping single-nucleotide alleles of the human HEXA gene responsible for Tay-Sachs disease and for genotyping SNP alleles near the human p53 tumor suppressor gene. In each case, the final probe signals were normalized against total single-stranded DNA generated in the same reaction. Normalization reduces the coefficient of variation among replicates from 17.22% to as little as 2.78% and permits endpoint genotyping with >99.7% accuracy. These assays are robust because they are consistent over a wide range of input DNA concentrations and give the same results regardless of how many cycles of linear amplification have elapsed. The method is also sufficiently powerful to distinguish between samples with a 1:1 ratio of two alleles from samples comprised of

  5. Evaluation of quantitative planar 90Y bremsstrahlung whole-body imaging

    International Nuclear Information System (INIS)

    Minarik, D; Ljungberg, M; Gleisner, K Sjoegreen; Segars, P

    2009-01-01

    With high-dose administration of 90 Y labeled antibodies, it is possible to image 90 Y without an admixture of 111 In. We have earlier shown that it is possible to perform quantitative 90 Y bremsstrahlung SPECT for dosimetry purposes with reasonable accuracy. However, whole-body (WB) activity quantification with the conjugate view method is not as time consuming as SPECT and has been the method of choice for dosimetry. We have investigated the possibility of using a conjugate view method where scatter-, backscatter- and septal-penetration compensations are performed by inverse filtering and attenuation correction is performed with a WB x-ray image, for total-body and organ activity quantification of 90 Y. The method was evaluated using both Monte Carlo simulated scintillation camera images using realistic source distributions, and by an experimental phantom study. The method was evaluated in terms of image quality and accuracy of the activity quantification. The experimental phantom study was performed using the RSD torso phantom with 90 Y activity uniformly distributed in the liver insert. A GE Discovery VH/Hawkeye system was used to acquire the image. The simulation study was performed for a realistic activity distribution in the NCAT anthropomorphic phantom where 90 Y bremsstrahlung images were generated using the SIMIND MC program. Two different phantom configurations and two activity distributions were simulated. To mimic the RSD phantom experiment one simulation study was also made with 90 Y activity located only in the liver. The SIMIND program was configured to resemble a GE Discovery VH/Hawkeye system. An x-ray projector program was used to generate whole-body x-ray images from the NCAT phantom for attenuation correction in the conjugate view method. Organ activities were calculated from ROIs that exactly covered the organs. Corrections for background activity, overlapping activity and source extension in the depth direction were applied on the ROI data

  6. Endpoint-based parallel data processing in a parallel active messaging interface of a parallel computer

    Science.gov (United States)

    Archer, Charles J.; Blocksome, Michael A.; Ratterman, Joseph D.; Smith, Brian E.

    2014-08-12

    Endpoint-based parallel data processing in a parallel active messaging interface (`PAMI`) of a parallel computer, the PAMI composed of data communications endpoints, each endpoint including a specification of data communications parameters for a thread of execution on a compute node, including specifications of a client, a context, and a task, the compute nodes coupled for data communications through the PAMI, including establishing a data communications geometry, the geometry specifying, for tasks representing processes of execution of the parallel application, a set of endpoints that are used in collective operations of the PAMI including a plurality of endpoints for one of the tasks; receiving in endpoints of the geometry an instruction for a collective operation; and executing the instruction for a collective operation through the endpoints in dependence upon the geometry, including dividing data communications operations among the plurality of endpoints for one of the tasks.

  7. Energetic endpoints provide early indicators of life history effects in a freshwater gastropod exposed to the fungicide, pyraclostrobin.

    Science.gov (United States)

    Fidder, Bridgette N; Reátegui-Zirena, Evelyn G; Olson, Adric D; Salice, Christopher J

    2016-04-01

    Organismal energetics provide important insights into the effects of environmental toxicants. We aimed to determine the effects of pyraclostrobin on Lymnaea stagnalis by examining energy allocation patterns and life history traits. Juvenile snails exposed to pyraclostrobin decreased feeding rate and increased apparent avoidance behaviors at environmentally relevant concentrations. In adults, we found that sublethal concentrations of pyraclostrobin did not affect reproductive output, however, there were significant effects on developmental endpoints with longer time to hatch and decreased hatching success in pyraclostrobin-exposed egg masses. Further, there were apparent differences in developmental effects depending on whether mothers were also exposed to pyraclostrobin suggesting this chemical can exert intergenerational effects. Pyraclostrobin also affected protein and carbohydrate content of eggs in mothers that were exposed to pyraclostrobin. Significant effects on macronutrient content of eggs occurred at lower concentrations than effects on gross endpoints such as hatching success and time to hatch suggesting potential value for these endpoints as early indicators of ecologically relevant stress. These results provide important insight into the effects of a common fungicide on important endpoints for organismal energetics and life history. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. On the possibility of a quantum bremsstrahlung induced self-modulation of a relativistic beam channeling in crystals

    International Nuclear Information System (INIS)

    Vysotskij, V.I.; Vorontsov, V.I.; Kuz'min, R.N.

    1987-01-01

    Physical predictions and quantitative estimations of a new physical effect - the phenomenon of quantum bremsstrahlung induced selfmodulation of a fast beam channeling in the crystals are considered and carried out. The occurrence of induced self-modulation results from nonstationary interference of proper waves of a channeled particle in the range of mutual coherence and with account of difference of selective bremsstrahlung losses of these waves. The modulation frequency for superrelativistic particles is shown to lie within the range from soft X-ray to hard gamma range. It proceeds from the estimations that modulation at these frequencies is preserved within the limits of macroscopically large ranges after the crystal attaining several meters. The maximum frequency of modulation for nonrelativistic heavy particles (protons) corresponds to the optical range

  9. Qualitative comparison of bremsstrahlung X-rays and 800 MeV protons for tomography of urania fuel pellets

    Energy Technology Data Exchange (ETDEWEB)

    Morris, C. L.; Bourke, M.; Byler, D. D.; Chen, C. F.; Hogan, G.; Hunter, J. F.; Kwiatkowski, K.; Mariam, F. G.; McClellan, K. J.; Merrill, F.; Morley, D. J.; Saunders, A. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)

    2013-02-15

    We present an assessment of x-rays and proton tomography as tools for studying the time dependence of the development of damage in fuel rods. We also show data taken with existing facilities at Los Alamos National Laboratory that support this assessment. Data on surrogate fuel rods have been taken using the 800 MeV proton radiography (pRad) facility at the Los Alamos Neutron Science Center (LANSCE), and with a 450 keV bremsstrahlung X-ray tomography facility. The proton radiography pRad facility at LANSCE can provide good position resolution (<70 {mu}m has been demonstrate, 20 {mu}m seems feasible with minor changes) for tomography on activated fuel rods. Bremsstrahlung x-rays may be able to provide better than 100 {mu}m resolution but further development of sources, collimation, and detectors is necessary for x-rays to deal with the background radiation for tomography of activated fuel rods.

  10. Qualitative comparison of bremsstrahlung X-rays and 800 MeV protons for tomography of urania fuel pellets

    International Nuclear Information System (INIS)

    Morris, C. L.; Bourke, M.; Byler, D. D.; Chen, C. F.; Hogan, G.; Hunter, J. F.; Kwiatkowski, K.; Mariam, F. G.; McClellan, K. J.; Merrill, F.; Morley, D. J.; Saunders, A.

    2013-01-01

    We present an assessment of x-rays and proton tomography as tools for studying the time dependence of the development of damage in fuel rods. We also show data taken with existing facilities at Los Alamos National Laboratory that support this assessment. Data on surrogate fuel rods have been taken using the 800 MeV proton radiography (pRad) facility at the Los Alamos Neutron Science Center (LANSCE), and with a 450 keV bremsstrahlung X-ray tomography facility. The proton radiography pRad facility at LANSCE can provide good position resolution (<70 μm has been demonstrate, 20 μm seems feasible with minor changes) for tomography on activated fuel rods. Bremsstrahlung x-rays may be able to provide better than 100 μm resolution but further development of sources, collimation, and detectors is necessary for x-rays to deal with the background radiation for tomography of activated fuel rods.

  11. Shielded radiography with a laser-driven MeV-energy X-ray source

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Shouyuan; Golovin, Grigory [Department of Physics and Astronomy, University of Nebraska-Lincoln, Lincoln, NE 68588 (United States); Miller, Cameron [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Haden, Daniel; Banerjee, Sudeep; Zhang, Ping; Liu, Cheng; Zhang, Jun; Zhao, Baozhen [Department of Physics and Astronomy, University of Nebraska-Lincoln, Lincoln, NE 68588 (United States); Clarke, Shaun; Pozzi, Sara [Department of Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Umstadter, Donald, E-mail: donald.umstadter@unl.edu [Department of Physics and Astronomy, University of Nebraska-Lincoln, Lincoln, NE 68588 (United States)

    2016-01-01

    We report the results of experimental and numerical-simulation studies of shielded radiography using narrowband MeV-energy X-rays from a compact all-laser-driven inverse-Compton-scattering X-ray light source. This recently developed X-ray light source is based on a laser-wakefield accelerator with ultra-high-field gradient (GeV/cm). We demonstrate experimentally high-quality radiographic imaging (image contrast of 0.4 and signal-to-noise ratio of 2:1) of a target composed of 8-mm thick depleted uranium shielded by 80-mm thick steel, using a 6-MeV X-ray beam with a spread of 45% (FWHM) and 10{sup 7} photons in a single shot. The corresponding dose of the X-ray pulse measured in front of the target is ∼100 nGy/pulse. Simulations performed using the Monte-Carlo code MCNPX accurately reproduce the experimental results. These simulations also demonstrate that the narrow bandwidth of the Compton X-ray source operating at 6 and 9 MeV leads to a reduction of deposited dose as compared to broadband bremsstrahlung sources with the same end-point energy. The X-ray beam’s inherently low-divergence angle (∼mrad) is advantageous and effective for interrogation at standoff distance. These results demonstrate significant benefits of all-laser driven Compton X-rays for shielded radiography.

  12. Technical Considerations of Phosphorous-32 Bremsstrahlung SPECT Imaging after Radio embolization of Hepatic Tumors: A Clinical Assessment with a Review of Imaging Parameters

    International Nuclear Information System (INIS)

    Pirayesh, E.; Amoui, M.; Khorrami, M.; Akhlaghpoor, Sh.; Tolooee, Sh.; PoorBeigi, H.; Sheibani, Sh.; Assadi, M.

    2014-01-01

    Bremsstrahlung (BS) imaging during radio embolization (RE) confirms the deposition of radiotracer in hepatic/extrahepatic tumors. The aim of this study is to demonstrate '3 2 P images and to optimize the imaging parameters. Materials and Methods. Thirty-nine patients with variable types of hepatic tumors, treated with the intra-arterial injection of 32 P, were included. All patients underwent BS SPECT imaging 24-72 h after tracer administration, using low energy high resolution (LEHR) (18 patients) or medium energy general purpose (MEGP) (21 patients) collimators. A grading scale from 1 to 4 was used to express the compatibility of the 32 P images with those obtained from CT/MRI. Results. Although the image quality obtained with the MEGP collimator was visually and quantitatively better than with the LEHR (76% concordance score versus 71%, resp.), there was no statistically significant difference between them. Conclusion. The MEGP collimator is the first choice for BS SPECT imaging. However, if the collimator change is time consuming (as in a busy center) or an MEGP collimator is not available, the LEHR collimator could be practical with acceptable images, especially in a SPECT study. In addition, BS imaging is a useful method to confirm the proper distribution of radiotherapeutic agents and has good correlation with anatomical findings.

  13. Verification of models for ballistic movement time and endpoint variability.

    Science.gov (United States)

    Lin, Ray F; Drury, Colin G

    2013-01-01

    A hand control movement is composed of several ballistic movements. The time required in performing a ballistic movement and its endpoint variability are two important properties in developing movement models. The purpose of this study was to test potential models for predicting these two properties. Twelve participants conducted ballistic movements of specific amplitudes using a drawing tablet. The measured data of movement time and endpoint variability were then used to verify the models. This study was successful with Hoffmann and Gan's movement time model (Hoffmann, 1981; Gan and Hoffmann 1988) predicting more than 90.7% data variance for 84 individual measurements. A new theoretically developed ballistic movement variability model, proved to be better than Howarth, Beggs, and Bowden's (1971) model, predicting on average 84.8% of stopping-variable error and 88.3% of aiming-variable errors. These two validated models will help build solid theoretical movement models and evaluate input devices. This article provides better models for predicting end accuracy and movement time of ballistic movements that are desirable in rapid aiming tasks, such as keying in numbers on a smart phone. The models allow better design of aiming tasks, for example button sizes on mobile phones for different user populations.

  14. Imaging biomarkers as surrogate endpoints for drug development

    International Nuclear Information System (INIS)

    Richter, Wolf S.

    2006-01-01

    The employment of biomarkers (including imaging biomarkers, especially PET) in drug development has gained increasing attention during recent years. This has been partly stimulated by the hope that the integration of biomarkers into drug development programmes may be a means to increase the efficiency and effectiveness of the drug development process by early identification of promising drug candidates - thereby counteracting the rising costs of drug development. More importantly, however, the interest in biomarkers for drug development is the logical consequence of recent advances in biosciences and medicine which are leading to target-specific treatments in the framework of ''personalised medicine''. A considerable proportion of target-specific drugs will show effects in subgroups of patients only. Biomarkers are a means to identify potential responders, or patient subgroups at risk for specific side-effects. Biomarkers are used in early drug development in the context of translational medicine to gain information about the drug's potential in different patient groups and disease states. The information obtained at this stage is mainly important for designing subsequent clinical trials and to identify promising drug candidates. Biomarkers in later phases of clinical development may - if properly validated - serve as surrogate endpoints for clinical outcomes. Regulatory agencies in the EU and the USA have facilitated the use of biomarkers early in the development process. The validation of biomarkers as surrogate endpoints is part of FDA's ''critical path initiative''. (orig.)

  15. Time-dependent efficacy of longitudinal biomarker for clinical endpoint.

    Science.gov (United States)

    Kolamunnage-Dona, Ruwanthi; Williamson, Paula R

    2018-06-01

    Joint modelling of longitudinal biomarker and event-time processes has gained its popularity in recent years as they yield more accurate and precise estimates. Considering this modelling framework, a new methodology for evaluating the time-dependent efficacy of a longitudinal biomarker for clinical endpoint is proposed in this article. In particular, the proposed model assesses how well longitudinally repeated measurements of a biomarker over various time periods (0,t) distinguish between individuals who developed the disease by time t and individuals who remain disease-free beyond time t. The receiver operating characteristic curve is used to provide the corresponding efficacy summaries at various t based on the association between longitudinal biomarker trajectory and risk of clinical endpoint prior to each time point. The model also allows detecting the time period over which a biomarker should be monitored for its best discriminatory value. The proposed approach is evaluated through simulation and illustrated on the motivating dataset from a prospective observational study of biomarkers to diagnose the onset of sepsis.

  16. Cortical plasticity as a new endpoint measurement for chronic pain

    Directory of Open Access Journals (Sweden)

    Zhuo Min

    2011-07-01

    Full Text Available Abstract Animal models of chronic pain are widely used to investigate basic mechanisms of chronic pain and to evaluate potential novel drugs for treating chronic pain. Among the different criteria used to measure chronic pain, behavioral responses are commonly used as the end point measurements. However, not all chronic pain conditions can be easily measured by behavioral responses such as the headache, phantom pain and pain related to spinal cord injury. Here I propose that cortical indexes, that indicate neuronal plastic changes in pain-related cortical areas, can be used as endpoint measurements for chronic pain. Such cortical indexes are not only useful for those chronic pain conditions where a suitable animal model is lacking, but also serve as additional screening methods for potential drugs to treat chronic pain in humans. These cortical indexes are activity-dependent immediate early genes, electrophysiological identified plastic changes and biochemical assays of signaling proteins. It can be used to evaluate novel analgesic compounds that may act at peripheral or spinal sites. I hope that these new cortical endpoint measurements will facilitate our search for new, and more effective, pain medicines, and help to reduce false lead drug targets.

  17. A yeast screening system for simultaneously monitoring multiple genetic endpoints

    International Nuclear Information System (INIS)

    Dixon, M.L.; Mortimer, R.K.

    1986-01-01

    Mutation, recombination, and mitochondrial deficiencies have been proposed to have roles in the carcinogenic process. The authors describe a diploid strain of the yeast Saccharomyces cerevisiae capable of detecting this wide spectrum of genetic changes. The markers used for monitoring these events have been especially well characterized genetically. Ultraviolet light was chosen as a model carcinogenic agent to test this system. In addition to highly significant increases in the frequencies of each genetic change, increases in the absolute numbers of each change indicated induction and not selective survival. The relative amounts of each type of genetic change varied with dose. The wide spectrum of endpoints monitored in the XD83 yeast system may allow the detection of certain carcinogens and other genetically toxic agents which have escaped detection in more limited systems. Since only one strain is required to simultaneously monitor these genetic changes, this assay system should facilitate comparisons of the induced changes and be more efficient than using multiple strains to monitor the same endpoints. (Auth.)

  18. Hydramite II screening tests of potential bremsstrahlung converter debris shield materials

    International Nuclear Information System (INIS)

    Reedy, E.D. Jr.; Hedemann, M.A.; Stark, M.A.

    1986-03-01

    Results of a brief test series aimed at screening a number of potential bremsstrahlung converter debris shield materials are reported. These tests were run on Sandia National Laboratories' Hydramite II accelerator using a diode configuration which produces a pinched electron beam. The materials tested include: (1) laminated Kevlar 49/polyester and E-glass/polyester composites, (2) a low density laminated Kevlar 49 composite, and (3) two types of through-the-thickness reinforced Kevlar 49 composites. As expected, tests using laminated Kevlar 49/polyester shields showed that shield permanent set (i.e., permanent deflection) increased with increasing tantalum conversion foil thickness and decreased with increasing shield thickness. The through-the-thickness reinforced composites developed localized, but severe, back surface damage. The laminated composites displayed little back surface damage, although extensive internal matrix cracking and ply delaminations were generated. Roughly the same degree of permanent set was produced in shields made from the low density Kevlar 49 composite and the Kevlar 49/polyester. The E-glass reinforced shields exhibited relatively low levels of permanent set

  19. Inverse bremsstrahlung heating beyond the first Born approximation for dense plasmas in laser fields

    International Nuclear Information System (INIS)

    Moll, M; Schlanges, M; Bornath, Th; Krainov, V P

    2012-01-01

    Inverse bremsstrahlung (IB) heating, an important process in the laser-matter interaction, involves two different kinds of interaction—the interaction of the electrons with the external laser field and the electron-ion interaction. This makes analytical approaches very difficult. In a quantum perturbative approach to the IB heating rate in strong laser fields, usually the first Born approximation with respect to the electron-ion potential is considered, whereas the influence of the electric field is taken exactly in the Volkov wave functions. In this paper, a perturbative treatment is presented adopting a screened electron-ion interaction potential. As a new result, we derive the momentum-dependent, angle-averaged heating rate in the first Born approximation. Numerical results are discussed for a broad range of field strengths, and the conditions for the applicability of a linear approximation for the heating rate are analyzed in detail. Going a step further in the perturbation series, we consider the transition amplitude in the second Born approximation, which enables us to calculate the heating rate up to the third order of the interaction strength. (paper)

  20. Alternative Endpoints and Approaches for the Remediation of Contaminated Groundwater at Complex Sites - 13426

    Energy Technology Data Exchange (ETDEWEB)

    Deeb, Rula A.; Hawley, Elisabeth L. [ARCADIS, U.S., 2000 Powell St., 7th Floor, Emeryville, California 94608 (United States)

    2013-07-01

    The goal of United States (U.S.) Department of Energy's (DOE)'s environmental remediation programs is to restore groundwater to beneficial use, similar to many other Federal and state environmental cleanup programs. Based on past experience, groundwater remediation to pre-contamination conditions (i.e., drinking water standards or non-detectable concentrations) can be successfully achieved at many sites. At a subset of the most complex sites, however, complete restoration is not likely achievable within the next 50 to 100 years using today's technology. This presentation describes several approaches used at complex sites in the face of these technical challenges. Many complex sites adopted a long-term management approach, whereby contamination was contained within a specified area using active or passive remediation techniques. Consistent with the requirements of their respective environmental cleanup programs, several complex sites selected land use restrictions and used risk management approaches to accordingly adopt alternative cleanup goals (alternative endpoints). Several sites used long-term management designations and approaches in conjunction with the alternative endpoints. Examples include various state designations for groundwater management zones, technical impracticability (TI) waivers or greater risk waivers at Superfund sites, and the use of Monitored Natural Attenuation (MNA) or other passive long-term management approaches over long time frames. This presentation will focus on findings, statistics, and case studies from a recently-completed report for the Department of Defense's Environmental Security Technology Certification Program (ESTCP) (Project ER-0832) on alternative endpoints and approaches for groundwater remediation at complex sites under a variety of Federal and state cleanup programs. The primary objective of the project was to provide environmental managers and regulators with tools, metrics, and information needed

  1. Alternative Endpoints and Approaches for the Remediation of Contaminated Groundwater at Complex Sites - 13426

    International Nuclear Information System (INIS)

    Deeb, Rula A.; Hawley, Elisabeth L.

    2013-01-01

    The goal of United States (U.S.) Department of Energy's (DOE)'s environmental remediation programs is to restore groundwater to beneficial use, similar to many other Federal and state environmental cleanup programs. Based on past experience, groundwater remediation to pre-contamination conditions (i.e., drinking water standards or non-detectable concentrations) can be successfully achieved at many sites. At a subset of the most complex sites, however, complete restoration is not likely achievable within the next 50 to 100 years using today's technology. This presentation describes several approaches used at complex sites in the face of these technical challenges. Many complex sites adopted a long-term management approach, whereby contamination was contained within a specified area using active or passive remediation techniques. Consistent with the requirements of their respective environmental cleanup programs, several complex sites selected land use restrictions and used risk management approaches to accordingly adopt alternative cleanup goals (alternative endpoints). Several sites used long-term management designations and approaches in conjunction with the alternative endpoints. Examples include various state designations for groundwater management zones, technical impracticability (TI) waivers or greater risk waivers at Superfund sites, and the use of Monitored Natural Attenuation (MNA) or other passive long-term management approaches over long time frames. This presentation will focus on findings, statistics, and case studies from a recently-completed report for the Department of Defense's Environmental Security Technology Certification Program (ESTCP) (Project ER-0832) on alternative endpoints and approaches for groundwater remediation at complex sites under a variety of Federal and state cleanup programs. The primary objective of the project was to provide environmental managers and regulators with tools, metrics, and information needed to evaluate

  2. Low dose response analysis through a cytogenetic end-point

    International Nuclear Information System (INIS)

    Bojtor, I.; Koeteles, G.J.

    1998-01-01

    The effects of low doses were studied on human lymphocytes of various individuals. The frequency of micronuclei in cytokinesis-blocked cultured lymphocytes was taken as end-point. The probability distribution of radiation-induced increment was statistically proved and identified as to be asymmetric when the blood samples had been irradiated with doses of 0.01-0.05 Gy of X-rays, similarly to that in unirradiated control population. On the contrary, at or above 1 Gy the corresponding normal curve could be accepted only reflecting an approximately symmetrical scatter of the increments about their mean value. It was found that the slope as well as the closeness of correlation of the variables considerably changed when lower and lower dose ranges had been selected. Below approximately 0.2 Gy even an unrelatedness was found betwen the absorbed dose and the increment

  3. Hausdorff dimension of exponential parameter rays and their endpoints

    International Nuclear Information System (INIS)

    Bailesteanu, Mihai; Balan, Horia Vlad; Schleicher, Dierk

    2008-01-01

    We investigate the set I of parameters κ for which the singular value of z map e z + κ converges to ∞. The set I consists of uncountably many parameter rays, plus landing points of some of these rays (Förster et al 2008 Proc Am. Math. Soc. 136 at press (Preprint math.DS/0311427)). We show that the parameter rays have Hausdorff dimension 1, which implies (Qiu 1994 Acta Math. Sin. (N.S.) 10 362–8) that the ray endpoints in I alone have dimension 2. Analogous results were known for dynamical planes of exponential maps (Karpińska 1999 C. R. Acad. Sci. Paris Sér. I: Math. 328 1039–44; Schleicher and Zimmer 2003 J. Lond. Math. Soc. 67 380–400); our result shows that this also holds in parameter space

  4. Biomarkers of intermediate endpoints in environmental and occupational health

    DEFF Research Database (Denmark)

    Knudsen, Lisbeth E; Hansen, Ase M

    2007-01-01

    The use of biomarkers in environmental and occupational health is increasing due to increasing demands on information about health risks from unfavourable exposures. Biomarkers provide information about individual loads. Biomarkers of intermediate endpoints benefit in comparison with biomarkers...... of exposure from the fact that they are closer to the adverse outcome in the pathway from exposure to health effects and may provide powerful information for intervention. Some biomarkers are specific, e.g., DNA and protein adducts, while others are unspecific like the cytogenetic biomarkers of chromosomal...... health effect from the result of the measurement has been performed for the cytogenetic biomarkers showing a predictive value of high levels of CA and increased risk of cancer. The use of CA in future studies is, however, limited by the laborious and sensitive procedure of the test and lack of trained...

  5. Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited)

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, C. M., E-mail: coopercm@fusion.gat.com [Oak Ridge Associated Universities, Oak Ridge, Tennessee 37830 (United States); Pace, D. C.; Paz-Soldan, C.; Eidietis, N. W. [General Atomics, P.O. Box 85608, San Diego, California 92186-5608 (United States); Commaux, N.; Shiraki, D. [Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830 (United States); Hollmann, E. M. [University of California, San Diego, La Jolla, California 92093-0533 (United States)

    2016-11-15

    A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5–100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead “pinhole camera” mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20 000 pulses per second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.

  6. Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited)

    International Nuclear Information System (INIS)

    Cooper, C. M.; Pace, D. C.; Paz-Soldan, C.; Eidietis, N. W.; Commaux, N.; Shiraki, D.; Hollmann, E. M.

    2016-01-01

    A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5–100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead “pinhole camera” mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20 000 pulses per second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.

  7. 90Y microsphere therapy: does 90Y PET/CT imaging obviate the need for 90Y Bremsstrahlung SPECT/CT imaging?

    Science.gov (United States)

    Zade, Anand A; Rangarajan, Venkatesh; Purandare, Nilendu C; Shah, Sneha A; Agrawal, Archi R; Kulkarni, Suyash S; Shetty, Nitin

    2013-11-01

    Transarterial radioembolization using Y microspheres is a novel therapeutic option for inoperable hepatic malignancies. As these spheres are radiolucent, real-time assessment of their distribution during the infusion process under fluoroscopic guidance is not possible. Bremsstrahlung radiations arising from 90Y have conventionally been used for imaging its biodistribution. Recent studies have proved that sources of 90Y also emit positrons, which can further be used for PET/computed tomography (CT) imaging. This study aimed to assess the feasibility of 90Y PET/CT imaging in evaluating microsphere distributions and to compare its findings with those of Bremsstrahlung imaging. Thirty-five sessions of 90Y microsphere transarterial radioembolization were performed on 30 patients with hepatic malignancies. 90Y PET/CT imaging was performed within 3 h of therapy. Bremsstrahlung imaging was also performed for each patient. The imaging findings were compared for concordance in the distribution of microspheres. Exact one-to-one correspondence between 90Y PET/CT imaging and 90Y Bremsstrahlung imaging was observed in 97.14% of cases (i.e. in 34/35 cases). Discordance was observed only in one case in which 90Y PET/CT imaging resolved the microsphere uptake in the inferior vena cava tumor thrombus, which was, however, not visualized on Bremsstrahlung imaging. There is good concordance in the imaging findings of 90Y PET/CT and 90Y Bremsstrahlung imaging. 90Y PET/CT imaging scores over the conventionally used Bremsstrahlung imaging in terms of better resolution, ease of technique, and comparable image acquisition time. This makes it a preferred imaging modality for assessment of the distribution of 90Y microspheres.

  8. Relative Biological Effectiveness of HZE Particles for Chromosomal Exchanges and Other Surrogate Cancer Risk Endpoints.

    Directory of Open Access Journals (Sweden)

    Eliedonna Cacao

    Full Text Available The biological effects of high charge and energy (HZE particle exposures are of interest in space radiation protection of astronauts and cosmonauts, and estimating secondary cancer risks for patients undergoing Hadron therapy for primary cancers. The large number of particles types and energies that makeup primary or secondary radiation in HZE particle exposures precludes tumor induction studies in animal models for all but a few particle types and energies, thus leading to the use of surrogate endpoints to investigate the details of the radiation quality dependence of relative biological effectiveness (RBE factors. In this report we make detailed RBE predictions of the charge number and energy dependence of RBE's using a parametric track structure model to represent experimental results for the low dose response for chromosomal exchanges in normal human lymphocyte and fibroblast cells with comparison to published data for neoplastic transformation and gene mutation. RBE's are evaluated against acute doses of γ-rays for doses near 1 Gy. Models that assume linear or non-targeted effects at low dose are considered. Modest values of RBE (10 are predicted at low doses <0.1 Gy. The radiation quality dependence of RBE's against the effects of acute doses γ-rays found for neoplastic transformation and gene mutation studies are similar to those found for simple exchanges if a linear response is assumed at low HZE particle doses. Comparisons of the resulting model parameters to those used in the NASA radiation quality factor function are discussed.

  9. Production of a narrow band of 0.511-MeV radiation by use of the PHERMEX bremsstrahlung spectrum

    International Nuclear Information System (INIS)

    Stroscio, M.A.

    1976-06-01

    The pair production cross section is numerically integrated over a typical PHERMEX bremsstrahlung spectrum to obtain the probability of pair production in a target of nuclear charge Z, and density rho. The pair production cross section used herein is only approximate in that it neglects screening, neglects the Coulomb field for the emerging pair (first Born approximation), and neglects pair production by atomic electrons. In spite of these approximations, an order-of-magnitude estimate of the amount of 0.511-MeV radiation produced by a typical pulse is still given

  10. Inverse Bremsstrahlung Stabilization of Noise in the Generation of Ultra-short Intense Pulses by Backward Raman Amplification

    International Nuclear Information System (INIS)

    Berger, Richard L.; Clark, Daniel S.; Solodov, Andrei; Valeo, Ernest J.; Fisch, Nathaniel J.

    2003-01-01

    Inverse bremsstrahlung absorption of the pump laser beam in a backward Raman amplifier over the round-trip light transit time through the sub-critical density plasma can more than double the electron temperature of the plasma and produce time-varying axial temperature gradients. The resulting increased Landau damping of the plasma wave and detuning of the resonance can act to stabilize the pump against unwanted amplification of Langmuir noise without disrupting nonlinear amplification of the femtosecond seed pulse. Because the heating rate increases with the charge state Z, only low-Z plasmas (hydrogen, helium, or helium-hydrogen mixtures) will maintain a low enough temperature for efficient operation

  11. Use of bremsstrahlung information for the nondestructive characterization of radioactive waste packages; Nutzung von Bremsstrahlungsinformation zur zerstoerungsfreien Charakterisierung radioaktiver Abfallgebinde

    Energy Technology Data Exchange (ETDEWEB)

    Rohrmoser, Benjamin Paul

    2016-11-10

    In order to minimize pseudo activity whilst storage of radioactive waste packages it is required to determine the nuclide inventory as precisely as possible. The in Gamma spectra contained parts of bremsstrahlung can be used to identify and quantify certain beta nuclides. For this an analytical method has been developed. This was mainly tested with beta-emitter Sr-90 and Tm-170, as well as commonly present gamma-emitters in laboratory scale and actual 200 liter waste packages. As a result, non-destructive determination of radioactive wastes can be conducted more precisely.

  12. SpEnD: Linked Data SPARQL Endpoints Discovery Using Search Engines

    Science.gov (United States)

    Yumusak, Semih; Dogdu, Erdogan; Kodaz, Halife; Kamilaris, Andreas; Vandenbussche, Pierre-Yves

    In this study, a novel metacrawling method is proposed for discovering and monitoring linked data sources on the Web. We implemented the method in a prototype system, named SPARQL Endpoints Discovery (SpEnD). SpEnD starts with a "search keyword" discovery process for finding relevant keywords for the linked data domain and specifically SPARQL endpoints. Then, these search keywords are utilized to find linked data sources via popular search engines (Google, Bing, Yahoo, Yandex). By using this method, most of the currently listed SPARQL endpoints in existing endpoint repositories, as well as a significant number of new SPARQL endpoints, have been discovered. Finally, we have developed a new SPARQL endpoint crawler (SpEC) for crawling and link analysis.

  13. Inconsistent selection and definition of local and regional endpoints in breast cancer research.

    Science.gov (United States)

    Moossdorff, M; van Roozendaal, L M; Schipper, R-J; Strobbe, L J A; Voogd, A C; Tjan-Heijnen, V C G; Smidt, M L

    2014-12-01

    Results in breast cancer research are reported using study endpoints. Most are composite endpoints (such as locoregional recurrence), consisting of several components (for example local recurrence) that are in turn composed of specific events (such as skin recurrence). Inconsistent endpoint selection and definition might lead to unjustified conclusions when comparing study outcomes. This study aimed to determine which locoregional endpoints are used in breast cancer studies, and how these endpoints and their components are defined. PubMed was searched for breast cancer studies published in nine leading journals in 2011. Articles using endpoints with a local or regional component were included and definitions were compared. Twenty-three different endpoints with a local or regional component were extracted from 44 articles. Most frequently used were disease-free survival (25 articles), recurrence-free survival (7), local control (4), locoregional recurrence-free survival (3) and event-free survival (3). Different endpoints were used for similar outcomes. Of 23 endpoints, five were not defined and 18 were defined only partially. Of these, 16 contained a local and 13 a regional component. Included events were not specified in 33 of 57 (local) and 27 of 50 (regional) cases. Definitions of local components inconsistently included carcinoma in situ and skin and chest wall recurrences. Regional components inconsistently included specific nodal sites and skin and chest wall recurrences. Breast cancer studies use many different endpoints with a locoregional component. Definitions of endpoints and events are either not provided or vary between trials. To improve transparency, facilitate trial comparison and avoid unjustified conclusions, authors should report detailed definitions of all endpoints. © 2014 BJS Society Ltd. Published by John Wiley & Sons Ltd.

  14. Towards better environmental performance of wastewater sludge treatment using endpoint approach in LCA methodology

    Directory of Open Access Journals (Sweden)

    Isam Alyaseri

    2017-03-01

    Full Text Available The aim of this study is to use the life cycle assessment method to measure the environmental performance of the sludge incineration process in a wastewater treatment plant and to propose an alternative that can reduce the environmental impact. To show the damages caused by the treatment processes, the study aimed to use an endpoint approach in evaluating impacts on human health, ecosystem quality, and resources due to the processes. A case study was taken at Bissell Point Wastewater Treatment Plant in Saint Louis, Missouri, U.S. The plant-specific data along with literature data from technical publications were used to build an inventory, and then analyzed the environmental burdens from sludge handling unit in the year 2011. The impact assessment method chosen was ReCipe 2008. The existing scenario (dewatering-multiple hearth incineration-ash to landfill was evaluated and three alternative scenarios (fluid bed incineration and anaerobic digestion with and without land application with energy recovery from heat or biogas were proposed and analyzed to find the one with the least environmental impact. The existing scenario shows that the most significant impacts are related to depletion in resources and damage to human health. These impacts mainly came from the operation phase (electricity and fuel consumption and emissions related to combustion. Alternatives showed better performance than the existing scenario. Using ReCipe endpoint methodology, and among the three alternatives tested, the anaerobic digestion had the best overall environmental performance. It is recommended to convert to fluid bed incineration if the concerns were more about human health or to anaerobic digestion if the concerns were more about depletion in resources. The endpoint approach may simplify the outcomes of this study as follows: if the plant is converted to fluid bed incineration, it could prevent an average of 43.2 DALYs in human life, save 0.059 species in the area

  15. Sensitive endpoints in extended one-generation reproductive toxicity study versus two generation?

    DEFF Research Database (Denmark)

    Christiansen, Sofie

    . The protocol includes assessment of novel endpoints of concern and developmental landmarks such as anogenital distance, nipple retention (both sensitive endpoints for anti-androgenic effects in male offspring) and mammary gland development (sensitive endpoint for oestrogen action) and may also include...... during critical period of development in contrast to the parental generation. Retrospective analysis of available two-generation studies, however, indicate that the assessment included in the study of other endpoints in the male offspring such as histopathology of reproductive organs and semen quality...

  16. 21 CFR 314.510 - Approval based on a surrogate endpoint or on an effect on a clinical endpoint other than survival...

    Science.gov (United States)

    2010-04-01

    ... Serious or Life-Threatening Illnesses § 314.510 Approval based on a surrogate endpoint or on an effect on... well-controlled. The applicant shall carry out any such studies with due diligence. ...

  17. Log-gamma directed polymer with fixed endpoints via the replica Bethe Ansatz

    International Nuclear Information System (INIS)

    Thiery, Thimothée; Le Doussal, Pierre

    2014-01-01

    We study the model of a discrete directed polymer (DP) on a square lattice with homogeneous inverse gamma distribution of site random Boltzmann weights, introduced by Seppalainen (2012 Ann. Probab. 40 19–73). The integer moments of the partition sum, Z n -bar , are studied using a transfer matrix formulation, which appears as a generalization of the Lieb–Liniger quantum mechanics of bosons to discrete time and space. In the present case of the inverse gamma distribution the model is integrable in terms of a coordinate Bethe Ansatz, as discovered by Brunet. Using the Brunet-Bethe eigenstates we obtain an exact expression for the integer moments of Z n -bar for polymers of arbitrary lengths and fixed endpoint positions. Although these moments do not exist for all integer n, we are nevertheless able to construct a generating function which reproduces all existing integer moments and which takes the form of a Fredholm determinant (FD). This suggests an analytic continuation via a Mellin–Barnes transform and we thereby propose a FD ansatz representation for the probability distribution function (PDF) of Z and its Laplace transform. In the limit of a very long DP, this ansatz yields that the distribution of the free energy converges to the Gaussian unitary ensemble (GUE) Tracy-Widom distribution up to a non-trivial average and variance that we calculate. Our asymptotic predictions coincide with a result by Borodin et al (2013 Commun. Math. Phys. 324 215–32) based on a formula obtained by Corwin et al (2011 arXiv:1110.3489) using the geometric Robinson–Schensted–Knuth (gRSK) correspondence. In addition we obtain the dependence on the endpoint position and the exact elastic coefficient at a large time. We argue the equivalence between our formula and that of Borodin et al. As we will discuss, this provides a connection between quantum integrability and tropical combinatorics. (paper)

  18. Y-90 SPECT ML image reconstruction with a new model for tissue-dependent bremsstrahlung production using CT information: a proof-of-concept study

    Science.gov (United States)

    Lim, Hongki; Fessler, Jeffrey A.; Wilderman, Scott J.; Brooks, Allen F.; Dewaraja, Yuni K.

    2018-06-01

    While the yield of positrons used in Y-90 PET is independent of tissue media, Y-90 SPECT imaging is complicated by the tissue dependence of bremsstrahlung photon generation. The probability of bremsstrahlung production is proportional to the square of the atomic number of the medium. Hence, the same amount of activity in different tissue regions of the body will produce different numbers of bremsstrahlung photons. Existing reconstruction methods disregard this tissue-dependency, potentially impacting both qualitative and quantitative imaging of heterogeneous regions of the body such as bone with marrow cavities. In this proof-of-concept study, we propose a new maximum-likelihood method that incorporates bremsstrahlung generation probabilities into the system matrix, enabling images of the desired Y-90 distribution to be reconstructed instead of the ‘bremsstrahlung distribution’ that is obtained with existing methods. The tissue-dependent probabilities are generated by Monte Carlo simulation while bone volume fractions for each SPECT voxel are obtained from co-registered CT. First, we demonstrate the tissue dependency in a SPECT/CT imaging experiment with Y-90 in bone equivalent solution and water. Visually, the proposed reconstruction approach better matched the true image and the Y-90 PET image than the standard bremsstrahlung reconstruction approach. An XCAT phantom simulation including bone and marrow regions also demonstrated better agreement with the true image using the proposed reconstruction method. Quantitatively, compared with the standard reconstruction, the new method improved estimation of the liquid bone:water activity concentration ratio by 40% in the SPECT measurement and the cortical bone:marrow activity concentration ratio by 58% in the XCAT simulation.

  19. Diagnostics of pre-breakdown light emission in a helium coplanar barrier discharge: the presence of neutral bremsstrahlung

    Science.gov (United States)

    Navrátil, Zdeněk; Morávek, Tomáš; Ráheľ, Jozef; Čech, Jan; Lalinský, Ondřej; Trunec, David

    2017-05-01

    Weak light emission (˜10-3 of active discharge signal; average count rate ˜ 1 photon s-1 nm-1) associated with surface charge relaxation during the dark phase of a helium diffuse coplanar barrier discharge was studied by optical emission spectroscopy, using a technique of phase-resolved single photon counting. The optical emission spectra of the dark phase contained luminescent bands of the dielectrics used (Al2O3, AlN) and spectral lines from the gas constituents (OH*, {{{N}}}2* , {{{N}}}2+* , He*, He{}2* , O*). During the charge relaxation event, a broad continuum appeared in the optical emission spectra, consisting of bremsstrahlung radiation and amplified luminescence of the dielectric barrier. The analysis presented suggests that the bremsstrahlung radiation originated from slow electrons colliding with neutral helium atoms. The fitting procedure we developed reproduced well the observed shape of the continuum. Moreover, it provided a method for the determination of electric field strength in the discharge during this particular phase. The electric field reached 1 kV cm-1 during the charge relaxation event.

  20. Monte-Carlo calculations of forward directed bremsstrahlung produced by 20 and 45 MeV electrons on tungsten

    International Nuclear Information System (INIS)

    Goosman, D.R.

    1983-01-01

    The SANDYL Monte-Carlo code has been used to calculate the Bremsstrahlung photon production from beams of parallel electrons incident upon three target geometries. These are 20 MeV electrons onto 1 mm of tungsten + 59 mm of Be, which simulates the operating parameters of the FXR electron accelerator at LLNL Bldg. 801, 45 MeV electrons onto 1 mm of tungsten, and finally 45 MeV electrons onto 1 mm of tungsten and 147 mm of Be. The latter two situations simulate possible future modifications to the FXR accelerator. Graphs of the spectral shape of the Bremsstrahlung photons emitted with angles between 0 0 and 1 0 to the electron direction, the angular distribution of photon-MeV, and the dose reduction curves for each of the three geometries are given. The latter dose reduction curves allow one to calculate forward-directed photon fluxes in real-life situations where the electron beam has non-zero angular divergence

  1. EELOSS: the program for calculation of electron energy loss data

    International Nuclear Information System (INIS)

    Tanaka, Shun-ichi

    1980-10-01

    A computer code EELOSS has been developed to obtain the electron energy loss data required for shielding and dosimetry of beta- and gamma-rays in nuclear plants. With this code, the following data are obtainable for any energy from 0.01 to 15 MeV in any medium (metal, insulator, gas, compound, or mixture) composed of any choice of 69 elements with atomic number 1 -- 94: a) Collision stopping power, b) Restricted collision stopping power, c) Radiative stopping power, and d) Bremsstrahlung production cross section. The availability of bremsstrahlung production cross section data obtained by the EELOSS code is demonstrated by the comparison of calculated gamma-ray spectrum with measured one in Pb layer, where electron-photon cascade is included implicitly. As a result, it is concluded that the uncertainty in the bremsstrahlung production cross sections is negligible in the practical shielding calculations of gamma rays of energy less than 15 MeV, since the bremsstrahlung production cross sections increase with the gamma-ray energy and the uncertainty for them decreases with increasing the gamma-ray energy. Furthermore, the accuracy of output data of the EELOSS code is evaluated in comparison with experimental data, and satisfactory agreements are observed concerning the stopping power. (J.P.N.)

  2. Yields of Radionuclides Created by Photonuclear Reactions on Be, C, Na, Cl, and Ge, Using Bremsstrahlung of 150-MeV Electrons

    International Nuclear Information System (INIS)

    Dickens, J.K.

    2001-01-01

    The bremsstrahlung created by 150-MeV electrons impinging on a tantalum radiator was used to study photonuclear reactions on samples containing Be, C, Na, Cl and Ge. For Ge fifteen radioisotopes, ranging in half life between 2.6 min and 271 days, and in mass between 65 and 75, were obtained in sufficient amount to determine their yields quantitatively using known decay gamma-rays. Special equipment is described which was developed to create the bremsstrahlung using a beam-sharing mode, while minimizing the neutron flux on the sample. Relative production rates were determined. These were analyzed to provide absolute average cross sections for production of three reactions

  3. Is Doubling of Serum Creatinine a Valid Clinical 'Hard' Endpoint in Clinical Nephrology Trials?

    NARCIS (Netherlands)

    Lambers Heerspink, H. J.; Perkovic, V.; de Zeeuw, D.

    2011-01-01

    The composite of end stage renal disease (ESRD), doubling of serum creatinine and (renal) death, is a frequently used endpoint in randomized clinical trials in nephrology. Doubling of serum creatinine is a well-accepted part of this endpoint because a doubling of serum creatinine reflects a large

  4. Right-handed currents at B→ K l+l− kinematic endpoint

    Indian Academy of Sciences (India)

    2017-10-09

    Oct 9, 2017 ... The recent LHCb measured values of these observables are used to conclude an evidence of right-handed currents at the kinematic endpoint of this decay mode. As the conclusion is drawn at the maximum dilepton invariant mass square ( q 2 ) kinematic endpoint, it relies only on heavy quark symmetries ...

  5. Restoration for the future: Setting endpoints and targets and selecting indicators of progress and success

    Science.gov (United States)

    Daniel C. Dey; Callie Jo Schweitzer; John M. Kabrick

    2014-01-01

    Setting endpoints and targets in forest restoration is a complicated task that is best accomplished in cooperative partnerships that account for the ecology of the system, production of desired ecosystem goods and services, economics and well-being of society, and future environments. Clearly written and quantitative endpoints and intermediary targets need to be...

  6. Restoration for the future: endpoints, targets, and indicators of progress and success

    Science.gov (United States)

    Daniel C. Dey; Callie Jo. Schweitzer

    2014-01-01

    Setting endpoints and targets in forest restoration is a complicated task that is best accomplished in cooperative partnerships that account for the ecology of the system, production of desired ecosystem goods and services, economics and well-being of society, and future environments. Clearly described and quantitative endpoints and intermediary targets are needed to...

  7. Observations on Three Endpoint Properties and Their Relationship to Regulatory Outcomes of European Oncology Marketing Applications.

    Science.gov (United States)

    Liberti, Lawrence; Stolk, Pieter; McAuslane, James Neil; Schellens, Jan; Breckenridge, Alasdair M; Leufkens, Hubert

    2015-06-01

    Guidance and exploratory evidence indicate that the type of endpoints and the magnitude of their outcome can define a therapy's clinical activity; however, little empirical evidence relates specific endpoint properties with regulatory outcomes. We explored the relationship of 3 endpoint properties to regulatory outcomes by assessing 50 oncology marketing authorization applications (MAAs; reviewed from 2009 to 2013). Overall, 16 (32%) had a negative outcome. The most commonly used hard endpoints were overall survival (OS) and the duration of response or stable disease. OS was a component of 91% approved and 63% failed MAAs. The most commonly used surrogate endpoints were progression-free survival (PFS), response rate, and health-related quality of life assessments. There was no difference (p = .3801) between the approved and failed MAA cohorts in the proportion of hard endpoints used. A mean of slightly more than four surrogate endpoints were used per approved MAA compared with slightly more than two for failed MAAs. Longer OS and PFS duration outcomes were generally associated with approvals, often when not statistically significant. The approved cohort was associated with a preponderance of statistically significant (p < .05) improvements in primary endpoints (p < .0001 difference between the approved and failed groups). Three key endpoint properties (type of endpoint [hard/surrogate], magnitude of an endpoint outcome, and its statistical significance) are consistent with the European Medicines Agency guidance and, notwithstanding the contribution of unique disease-specific circumstances, are associated with a predictable positive outcome for oncology MAAs. Regulatory decisions made by the European Medicines Agency determine which new medicines will be available to European prescribers and for which therapeutic indications. Regulatory success or failure can be influenced by many factors. This study assessed three key properties of endpoints used in

  8. OPERA models for predicting physicochemical properties and environmental fate endpoints.

    Science.gov (United States)

    Mansouri, Kamel; Grulke, Chris M; Judson, Richard S; Williams, Antony J

    2018-03-08

    The collection of chemical structure information and associated experimental data for quantitative structure-activity/property relationship (QSAR/QSPR) modeling is facilitated by an increasing number of public databases containing large amounts of useful data. However, the performance of QSAR models highly depends on the quality of the data and modeling methodology used. This study aims to develop robust QSAR/QSPR models for chemical properties of environmental interest that can be used for regulatory purposes. This study primarily uses data from the publicly available PHYSPROP database consisting of a set of 13 common physicochemical and environmental fate properties. These datasets have undergone extensive curation using an automated workflow to select only high-quality data, and the chemical structures were standardized prior to calculation of the molecular descriptors. The modeling procedure was developed based on the five Organization for Economic Cooperation and Development (OECD) principles for QSAR models. A weighted k-nearest neighbor approach was adopted using a minimum number of required descriptors calculated using PaDEL, an open-source software. The genetic algorithms selected only the most pertinent and mechanistically interpretable descriptors (2-15, with an average of 11 descriptors). The sizes of the modeled datasets varied from 150 chemicals for biodegradability half-life to 14,050 chemicals for logP, with an average of 3222 chemicals across all endpoints. The optimal models were built on randomly selected training sets (75%) and validated using fivefold cross-validation (CV) and test sets (25%). The CV Q 2 of the models varied from 0.72 to 0.95, with an average of 0.86 and an R 2 test value from 0.71 to 0.96, with an average of 0.82. Modeling and performance details are described in QSAR model reporting format and were validated by the European Commission's Joint Research Center to be OECD compliant. All models are freely available as an open

  9. Defining the end-point of mastication: A conceptual model.

    Science.gov (United States)

    Gray-Stuart, Eli M; Jones, Jim R; Bronlund, John E

    2017-10-01

    properties define the end-point texture and enduring sensory perception of the food. © 2017 Wiley Periodicals, Inc.

  10. Endpoints and cutpoints in head and neck oncology trials: methodical background, challenges, current practice and perspectives.

    Science.gov (United States)

    Hezel, Marcus; von Usslar, Kathrin; Kurzweg, Thiemo; Lörincz, Balazs B; Knecht, Rainald

    2016-04-01

    This article reviews the methodical and statistical basics of designing a trial, with a special focus on the process of defining and choosing endpoints and cutpoints as the foundations of clinical research, and ultimately that of evidence-based medicine. There has been a significant progress in the treatment of head and neck cancer in the past few decades. Currently available treatment options can have a variety of different goals, depending e.g. on tumor stage, among other factors. The outcome of a specific treatment in clinical trials is measured using endpoints. Besides classical endpoints, such as overall survival or organ preservation, other endpoints like quality of life are becoming increasingly important in designing and conducting a trial. The present work is based on electronic research and focuses on the solid methodical and statistical basics of a clinical trial, on the structure of study designs and on the presentation of various endpoints.

  11. Elimination of endpoint-discontinuity artifacts in the analysis of spectra in reciprocal space

    International Nuclear Information System (INIS)

    Yoo, S. D.; Aspnes, D. E.

    2001-01-01

    Reciprocal-space analysis offers several advantages for determining critical point parameters in optical and other spectra, for example the separation of baseline effects, information, and noise in low-, medium-, and high-index Fourier coefficients, respectively. However, endpoint-discontinuity artifacts can obscure much of the information when segments are isolated for analysis. We developed a procedure for eliminating these artifacts and recovering buried information by minimizing in the white-noise region the mean-square deviation between the Fourier coefficients of the data and those of low-order polynomials, then subtracting the resulting coefficients from the data over the entire range. We find that spectral analysis is optimized if no false data are used, i.e., when the number of points transformed equals the number of actual data points in the segment. Using fractional differentiation we develop a simple derivation of the variation of the reciprocal-space coefficients with index n for Lorentzian and Gaussian line shapes in direct space. More generally, we show that the definition of critical point energies in terms of phase coherence of the Fourier coefficients allows these energies to be determined for a broad class of line shapes even if the direct-space line shapes themselves are not known. Limitations for undersampled or highly broadened spectra are discussed, along with extensions to two- or higher-dimensional arrays of data. [copyright] 2001 American Institute of Physics

  12. Determining significant endpoints for ecological risk analyses. 1997 annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Hinton, T.G.; Congdon, J.; Rowe, C.; Scott, D. [Univ. of Georgia, Aiken, SC (US). Savannah River Ecology Lab.; Bedford, J.; Whicker, F.W. [Colorado State Univ., Fort Collins, CO (US)

    1997-11-01

    'This report summarizes the first year''s progress of research funded under the Department of Energy''s Environmental Management Science Program. The research was initiated to better determine ecological risks from toxic and radioactive contaminants. More precisely, the research is designed to determine the relevancy of sublethal cellular damage to the performance of individuals and to identify characteristics of non-human populations exposed to chronic, low-level radiation, as is typically found on many DOE sites. The authors propose to establish a protocol to assess risks to non-human species at higher levels of biological organization by relating molecular damage to more relevant responses that reflect population health. They think that they can achieve this by coupling changes in metabolic rates and energy allocation patterns to meaningful population response variables, and by using novel biological dosimeters in controlled, manipulative dose/effects experiments. They believe that a scientifically defensible endpoint for measuring ecological risks can only be determined once its understood the extent to which molecular damage from contaminant exposure is detrimental at the individual and population levels of biological organization.'

  13. Novel X-ray imaging diagnostics of high energy nanosecond pulse accelerators

    International Nuclear Information System (INIS)

    Smith, Graham W.; Gallegos, Roque Rosauro; Hohlfelder, Robert James; Beutler, David Eric; Dudley, John; Seymour, Calvin L.G.; Bell, John D.

    2004-01-01

    Pioneering x-ray imaging has been undertaken on a number of AWE's and Sandia National Laboratories radiation effects x-ray simulators. These simulators typically yield a single very short (<50ns) pulse of high-energy (MeV endpoint energy bremsstrahlung) x-ray radiation with doses in the kilorad (krad(Si)) region. X-ray source targets vary in size from 2 to 25cm diameter, dependent upon the particular simulator. Electronic imaging of the source x-ray emission under dynamic conditions yields valuable information upon how the simulator is performing. The resultant images are of interest to the simulator designer who may configure new x-ray source converter targets and diode designs. The images can provide quantitative information about machine performance during radiation effects testing of components under active conditions. The effects testing program is a valuable interface for validation of high performance computer codes and models for the radiation effects community. A novel high-energy x-ray imaging spectrometer is described whereby the spectral energy (0.1 to 2.5MeV) profile may be discerned from the digitally recorded and viewable images via a pinhole/scintillator/CCD imaging system and knowledge of the filtration parameters. Unique images, analysis and a preliminary evaluation of the capability of the spectrometer are presented. Further, a novel time resolved imaging system is described that captures a sequence of high spatial resolution temporal images, with zero interframe time, in the nanosecond timeframe, of our source x-rays.

  14. Considerations in choosing a primary endpoint that measures durability of virological suppression in an antiretroviral trial.

    Science.gov (United States)

    Gilbert, P B; Ribaudo, H J; Greenberg, L; Yu, G; Bosch, R J; Tierney, C; Kuritzkes, D R

    2000-09-08

    At present, many clinical trials of anti-HIV-1 therapies compare treatments by a primary endpoint that measures the durability of suppression of HIV-1 replication. Several durability endpoints are compared. Endpoints are compared by their implicit assumptions regarding surrogacy for clinical outcomes, sample size requirements, and accommodations for inter-patient differences in baseline plasma HIV-1-RNA levels and in initial treatment response. Virological failure is defined by the non-suppression of virus levels at a prespecified follow-up time T(early virological failure), or by relapse. A binary virological failure endpoint is compared with three time-to-virological failure endpoints: time from (i) randomization that assigns early failures a failure time of T weeks; (ii) randomization that extends the early failure time T for slowly responding subjects; and (iii) virological response that assigns non-responders a failure time of 0 weeks. Endpoint differences are illustrated with Agouron's trial 511. In comparing high with low-dose nelfinavir (NFV) regimens in Agouron 511, the difference in Kaplan-Meier estimates of the proportion not failing by 24 weeks is 16.7% (P = 0.048), 6.5% (P = 0.29) and 22.9% (P = 0.0030) for endpoints (i), (ii) and (iii), respectively. The results differ because NFV suppresses virus more quickly at the higher dose, and the endpoints weigh this treatment difference differently. This illustrates that careful consideration needs to be given to choosing a primary endpoint that will detect treatment differences of interest. A time from randomization endpoint is usually recommended because of its advantages in flexibility and sample size, especially at interim analyses, and for its interpretation for patient management.

  15. A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Guozhu, E-mail: gzhang6@ncsu.edu [Bioinformatics Research Center, North Carolina State University, Raleigh, NC (United States); Roell, Kyle R., E-mail: krroell@ncsu.edu [Bioinformatics Research Center, North Carolina State University, Raleigh, NC (United States); Truong, Lisa, E-mail: lisa.truong@oregonstate.edu [Department of Environmental and Molecular Toxicology, Sinnhuber Aquatic Research Laboratory, Oregon State University, Corvallis, OR (United States); Tanguay, Robert L., E-mail: robert.tanguay@oregonstate.edu [Department of Environmental and Molecular Toxicology, Sinnhuber Aquatic Research Laboratory, Oregon State University, Corvallis, OR (United States); Reif, David M., E-mail: dmreif@ncsu.edu [Bioinformatics Research Center, North Carolina State University, Raleigh, NC (United States); Department of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, NC (United States)

    2017-01-01

    Zebrafish have become a key alternative model for studying health effects of environmental stressors, partly due to their genetic similarity to humans, fast generation time, and the efficiency of generating high-dimensional systematic data. Studies aiming to characterize adverse health effects in zebrafish typically include several phenotypic measurements (endpoints). While there is a solid biomedical basis for capturing a comprehensive set of endpoints, making summary judgments regarding health effects requires thoughtful integration across endpoints. Here, we introduce a Bayesian method to quantify the informativeness of 17 distinct zebrafish endpoints as a data-driven weighting scheme for a multi-endpoint summary measure, called weighted Aggregate Entropy (wAggE). We implement wAggE using high-throughput screening (HTS) data from zebrafish exposed to five concentrations of all 1060 ToxCast chemicals. Our results show that our empirical weighting scheme provides better performance in terms of the Receiver Operating Characteristic (ROC) curve for identifying significant morphological effects and improves robustness over traditional curve-fitting approaches. From a biological perspective, our results suggest that developmental cascade effects triggered by chemical exposure can be recapitulated by analyzing the relationships among endpoints. Thus, wAggE offers a powerful approach for analysis of multivariate phenotypes that can reveal underlying etiological processes. - Highlights: • Introduced a data-driven weighting scheme for multiple phenotypic endpoints. • Weighted Aggregate Entropy (wAggE) implies differential importance of endpoints. • Endpoint relationships reveal developmental cascade effects triggered by exposure. • wAggE is generalizable to multi-endpoint data of different shapes and scales.

  16. Mixed optical Cherenkov–Bremsstrahlung radiation in vicinity of the Cherenkov cone from relativistic heavy ions: Unusual dependence of the angular distribution width on the radiator thickness

    Energy Technology Data Exchange (ETDEWEB)

    Rozhkova, E.I., E-mail: elenafiks@gmail.com; Pivovarov, Yu.L.

    2016-07-15

    The Cherenkov radiation (ChR) angular distribution is usually described by the Tamm–Frank (TF) theory, which assumes that relativistic charged particle moves uniformly and rectilinearly in the optically transparent radiator. According to the TF theory, the full width at half maximum (FWHM) of the ChR angular distribution inversely depends on the radiator thickness. In the case of relativistic heavy ions (RHI) a slowing-down in the radiator may sufficiently change the angular distribution of optical radiation in vicinity of the Cherenkov cone, since there appears a mixed ChR–Bremsstrahlung radiation. As a result, there occurs a drastic transformation of the FWHM of optical radiation angular distribution in dependence on the radiator thickness: from inversely proportional (TF theory) to the linearly proportional one. In our paper we present the first analysis of this transformation taking account of the gradual velocity decrease of RHI penetrating through a radiator. - Highlights: • Stopping of relativistic heavy ions leads to appearance of a Cherenkov–Bremsstrahlung radiation near the Cherenkov cone. • Mixed Cherenkov–Bremsstrahlung optical radiation FWHM differs from the standard one determined by the Tamm–Frank theory. • The Cherenkov–Bremsstrahlung radiation angular distribution FWHM linearly depends on the radiator thickness.

  17. A BaF2 crystal array for high energy-ray measurements

    Indian Academy of Sciences (India)

    Abstract. We shall discuss about the scientific motivation and construction of a 7 × 7 BaF2 crystal array at Variable Energy Cyclotron Centre, Calcutta. This detector would be used to measure high energy -ray photons from GDR decay and proton–neutron bremsstrahlung reactions at the present 88'' cyclotron and upcoming ...

  18. Evaluation of early efficacy endpoints for proof-of-concept trials.

    Science.gov (United States)

    Chen, Cong; Sun, Linda; Li, Chih-Lin

    2013-03-11

    A Phase II proof-of-concept (POC) trial usually uses an early efficacy endpoint other than a clinical endpoint as the primary endpoint. Because of the advancement in bioscience and technology, which has yielded a number of new surrogate biomarkers, drug developers often have more candidate endpoints to choose from than they can handle. As a result, selection of endpoint and its effect size as well as choice of type I/II error rates are often at the center of heated debates in design of POC trials. While optimization of the trade-off between benefit and cost is the implicit objective in such a decision-making process, it is seldom explicitly accounted for in practice. In this research note, motivated by real examples from the oncology field, we provide practical measures for evaluation of early efficacy endpoints (E4) for POC trials. We further provide optimal design strategies for POC trials that include optimal Go-No Go decision criteria for initiation of Phase III and optimal resource allocation strategies for conducting multiple POC trials in a portfolio under fixed resources. Although oncology is used for illustration purpose, the same idea developed in this research note also applies to similar situations in other therapeutic areas or in early-stage drug development in that a Go-No Go decision has to rely on limited data from an early efficacy endpoint and cost-effectiveness is the main concern.

  19. Pollutant threshold concentration determination in marine ecosystems using an ecological interaction endpoint

    International Nuclear Information System (INIS)

    Wang, Changyou; Liang, Shengkang; Guo, Wenting; Yu, Hua; Xing, Wenhui

    2015-01-01

    The threshold concentrations of pollutants are determined by extrapolating single-species effect data to community-level effects. This assumes the most sensitive endpoint of the life cycle of individuals and the species sensitivity distribution from single-species toxic effect tests, thus, ignoring the ecological interactions. The uncertainties due to this extrapolation can be partially overcome using the equilibrium point of a customized ecosystem. This method incorporates ecological interactions and integrates the effects on growth, survival, and ingestion into a single effect measure, the equilibrium point excursion in the customized ecosystem, in order to describe the toxic effects on plankton. A case study showed that the threshold concentration of copper calculated with the endpoint of the equilibrium point was 10 μg L −1 , which is significantly different from the threshold calculated with a single-species endpoint. The endpoint calculated using this method provides a more relevant measure of the ecological impact than any single individual-level endpoint. - Highlights: • Ecotoxicological effect of exposure to copper was tested on a customized ecosystem. • Equilibrium point of biomasses in the customized ecosystem was used as an endpoint. • Exposure–response relationship in a community level was built on equilibrium point. • A threshold concentration incorporating ecological interactions was derived. - The equilibrium biomass incorporating ecological interactions in a customized ecosystem was used as an endpoint to calculate the threshold concentration at a community level

  20. A comparison of chemoembolization endpoints using angiographic versus transcatheter intraarterial perfusion/MR imaging monitoring.

    Science.gov (United States)

    Lewandowski, Robert J; Wang, Dingxin; Gehl, James; Atassi, Bassel; Ryu, Robert K; Sato, Kent; Nemcek, Albert A; Miller, Frank H; Mulcahy, Mary F; Kulik, Laura; Larson, Andrew C; Salem, Riad; Omary, Reed A

    2007-10-01

    Transcatheter arterial chemoembolization (TACE) is an established treatment for unresectable liver cancer. This study was conducted to test the hypothesis that angiographic endpoints during TACE are measurable and reproducible by comparing subjective angiographic versus objective magnetic resonance (MR) endpoints of TACE. The study included 12 consecutive patients who presented for TACE for surgically unresectable HCC or progressive hepatic metastases despite chemotherapy. All procedures were performed with a dedicated imaging system. Angiographic series before and after TACE were reviewed independently by three board-certified interventional radiologists. A subjective angiographic chemoembolization endpoint (SACE) classification scheme, modified from an established angiographic grading system in the cardiology literature, was designed to assist in reproducibly classifying angiographic endpoints. Reproducibility in SACE classification level was compared among operators, and MR imaging perfusion reduction was compared with SACE levels for each observer. Twelve patients successfully underwent 15 separate TACE sessions. SACE levels ranged from I through IV. There was moderate agreement in SACE classification (kappa = 0.46 +/- 0.12). There was no correlation between SACE level and MR perfusion reduction (r = 0.16 for one operator and 0.02 for the other two). Angiographic endpoints during TACE vary widely, have moderate reproducibility among operators, and do not correlate with functional MR imaging perfusion endpoints. Future research should aim to determine ideal angiographic and functional MR imaging endpoints for TACE according to outcome measures such as imaging response, pathologic response, and survival.

  1. A step towards standardization: A method for end-point titer determination by fluorescence index of an automated microscope. End-point titer determination by fluorescence index.

    Science.gov (United States)

    Carbone, Teresa; Gilio, Michele; Padula, Maria Carmela; Tramontano, Giuseppina; D'Angelo, Salvatore; Pafundi, Vito

    2018-05-01

    Indirect Immunofluorescence (IIF) is widely considered the Gold Standard for Antinuclear Antibody (ANA) screening. However, the high inter-reader variability remains the major disadvantage associated with ANA testing and the main reason for the increasing demand of the computer-aided immunofluorescence microscope. Previous studies proposed the quantification of the fluorescence intensity as an alternative for the classical end-point titer evaluation. However, the different distribution of bright/dark light linked to the nature of the self-antigen and its location in the cells result in different mean fluorescence intensities. The aim of the present study was to correlate Fluorescence Index (F.I.) with end-point titers for each well-defined ANA pattern. Routine serum samples were screened for ANA testing on HEp-2000 cells using Immuno Concepts Image Navigator System, and positive samples were serially diluted to assign the end-point titer. A comparison between F.I. and end-point titers related to 10 different staining patterns was made. According to our analysis, good technical performance of F.I. (97% sensitivity and 94% specificity) was found. A significant correlation between quantitative reading of F.I. and end-point titer groups was observed using Spearman's test and regression analysis. A conversion scale of F.I. in end-point titers for each recognized ANA-pattern was obtained. The Image Navigator offers the opportunity to improve worldwide harmonization of ANA test results. In particular, digital F.I. allows quantifying ANA titers by using just one sample dilution. It could represent a valuable support for the routine laboratory and an effective tool to reduce inter- and intra-laboratory variability. Copyright © 2018. Published by Elsevier B.V.

  2. A comparison of experiment, CEPXS/ONETRAN, TIGERP, and TIGER net electron emission coefficients for various bremsstrahlung spectra

    International Nuclear Information System (INIS)

    Ballard, W.P.; Lorence, L.J. Jr.; Snowden, D.P.; Van Lint, V.A.J.; Beale, E.S.

    1987-01-01

    This work compares a carefully designed experiment to measure photoemission with the predictions of three different codes (CEPXS/ONETRAN, TIGERP, and TIGER) for the complex bremsstrahlung spectra typical of very intense pulsed power x-ray generators. The Monte Carlo codes TIGER and TIGERP can calculate the net photon-induced electron emission but accurate results may require that statistical error be minimized. CEPXS/ONETRAN is a new deterministic coupled electron/photon transport code that is faster than Monte Carlo and is not subject to statistical error. The comparison of net yields is a sensitive test of the relative accuracy and efficiency of these various codes. The authors find that all of the codes substantially agree with the experiments for the forward net yields. However, for reverse net yields from high-Z materials, the codes overpredict relative to measurements

  3. Simple method for routine check of the constancy of radiation quality of bremsstrahlung emitted by therapeutic particle accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Rassow, J; Eipper, H H; Krause, K [Essen Univ. (Gesamthochschule) (Germany, F.R.). Abt. fuer Klinische Strahlenphysik; Staedtisches Krankenhaus Koeln-Merheim (Germany, F.R.). Roentgeninstitut und Strahlenklinik)

    1977-05-01

    The constancy of the radiation quality of therapeutically employed particle accelerators has to be checked at weekly intervals. Any change in radiation quality may have considerable therapeutic effects owing to its influence on dose distribution. It is recommended that measurements be made instead of, or in addition to, the axial reference-point measurement at 5 and 15 cm depth in the phantom, at 5 cm depth in the beam axis and at a reference-point about 1 cm within the geometric edge of the field, for checking the constancy of the radiation quality of bremsstrahlung. Only then, if routine checks carried out for the axial and the lateral reference-point dose ratios do not show any deviations greater than e.g. +-2 %, radiation quality is deemed to have remained sufficiently constant for radiotherapeutical applications.

  4. An effective potential for electron-nucleus scattering in neutrino-pair bremsstrahlung in neutron star crust

    International Nuclear Information System (INIS)

    Ofengeim, D D; Kaminker, A D; Yakovlev, D G

    2015-01-01

    We derive an analytic approximation for the emissivity of neutrino-pair bremsstrahlung (NPB) due to scattering of electrons by atomic nuclei in a neutron star (NS) crust of any realistic composition. The emissivity is expressed through generalized Coulomb logarithm by introducing an effective potential of electron-nucleus scattering. In addition, we study the conditions at which NPB in the crust is affected by strong magnetic fields and outline the main effects of the fields on neutrino emission in NSs. The results can be used for modelling of many phenomena in NSs, such as cooling of young isolated NSs, thermal relaxation of accreting NSs with overheated crust in soft X-ray transients and evolution of magnetars. (paper)

  5. Measurements and effects of backstreaming ions produced at bremsstrahlung converter target in Dragon-I linear induction accelerator

    International Nuclear Information System (INIS)

    Yu Haijun; Zhu Jun; Chen Nan; Xie Yutong; Jiang Xiaoguo; Jian Cheng

    2010-01-01

    Positive ions released from x-ray converter target impacted by electron beam of millimeter spot size can be trapped and accelerated in the incident beam's potential well. As the ions move upstream, the beam will be pinched first and then defocused at the target. Four Faraday cups are used to collect backstreaming ions produced at the bremsstrahlung converter target in Dragon-I linear induction accelerator (LIA). Experimental and theoretical results show that the backstreaming positive ions density and velocity are about 10 21 /m 3 and 2-3 mm/μs, respectively. The theoretical and experimental results of electron beam envelope with ions and without ions are also presented. The discussions show that the backstreaming positive ions will not affect the electron beam focusing and envelope radius in Dragon-I LIA.

  6. Ovarian cancer clinical trial endpoints: Society of Gynecologic Oncology white paper

    Science.gov (United States)

    Herzog, Thomas J.; Armstrong, Deborah K.; Brady, Mark F.; Coleman, Robert L.; Einstein, Mark H.; Monk, Bradley J.; Mannel, Robert S.; Thigpen, J. Tate; Umpierre, Sharee A.; Villella, Jeannine A.; Alvarez, Ronald D.

    2015-01-01

    Objective To explore the value of multiple clinical endpoints in the unique setting of ovarian cancer. Methods A clinical trial workgroup was established by the Society of Gynecologic Oncology to develop a consensus statement via multiple conference calls, meetings and white paper drafts. Results Clinical trial endpoints have profound effects on late phase clinical trial design, result interpretation, drug development, and regulatory approval of therapeutics. Selection of the optimal clinical trial endpoint is particularly provocative in ovarian cancer where long overall survival (OS) is observed. The lack of new regulatory approvals and the lack of harmony between regulatory bodies globally for ovarian cancer therapeutics are of concern. The advantages and disadvantages of the numerous endpoints available are herein discussed within the unique context of ovarian cancer where both crossover and post-progression therapies potentially uncouple surrogacy between progression-free survival (PFS) and OS, the two most widely supported and utilized endpoints. The roles of patient reported outcomes (PRO) and health related quality of life (HRQoL) are discussed, but even these widely supported parameters are affected by the unique characteristics of ovarian cancer where a significant percentage of patients may be asymptomatic. Original data regarding the endpoint preferences of ovarian cancer advocates is presented. Conclusions Endpoint selection in ovarian cancer clinical trials should reflect the impact on disease burden and unique characteristics of the treatment cohort while reflecting true patient benefit. Both OS and PFS have led to regulatory approvals and are clinically important. OS remains the most objective and accepted endpoint because it is least vulnerable to bias; however, the feasibility of OS in ovarian cancer is compromised by the requirement for large trial size, prolonged time-line for final analysis, and potential for unintended loss of treatment effect

  7. Ovarian cancer clinical trial endpoints: Society of Gynecologic Oncology white paper.

    Science.gov (United States)

    Herzog, Thomas J; Armstrong, Deborah K; Brady, Mark F; Coleman, Robert L; Einstein, Mark H; Monk, Bradley J; Mannel, Robert S; Thigpen, J Tate; Umpierre, Sharee A; Villella, Jeannine A; Alvarez, Ronald D

    2014-01-01

    To explore the value of multiple clinical endpoints in the unique setting of ovarian cancer. A clinical trial workgroup was established by the Society of Gynecologic Oncology to develop a consensus statement via multiple conference calls, meetings and white paper drafts. Clinical trial endpoints have profound effects on late phase clinical trial design, result interpretation, drug development, and regulatory approval of therapeutics. Selection of the optimal clinical trial endpoint is particularly provocative in ovarian cancer where long overall survival (OS) is observed. The lack of new regulatory approvals and the lack of harmony between regulatory bodies globally for ovarian cancer therapeutics are of concern. The advantages and disadvantages of the numerous endpoints available are herein discussed within the unique context of ovarian cancer where both crossover and post-progression therapies potentially uncouple surrogacy between progression-free survival (PFS) and OS, the two most widely supported and utilized endpoints. The roles of patient reported outcomes (PRO) and health related quality of life (HRQoL) are discussed, but even these widely supported parameters are affected by the unique characteristics of ovarian cancer where a significant percentage of patients may be asymptomatic. Original data regarding the endpoint preferences of ovarian cancer advocates is presented. Endpoint selection in ovarian cancer clinical trials should reflect the impact on disease burden and unique characteristics of the treatment cohort while reflecting true patient benefit. Both OS and PFS have led to regulatory approvals and are clinically important. OS remains the most objective and accepted endpoint because it is least vulnerable to bias; however, the feasibility of OS in ovarian cancer is compromised by the requirement for large trial size, prolonged time-line for final analysis, and potential for unintended loss of treatment effect from active post-progression therapies

  8. Gene expression profiles in auricle skin as a possible additional endpoint for determination of sensitizers: A multi-endpoint evaluation of the local lymph node assay.

    Science.gov (United States)

    Tsuchiyama, Hiromi; Maeda, Akihisa; Nakajima, Mayumi; Kitsukawa, Mika; Takahashi, Kei; Miyoshi, Tomoya; Mutsuga, Mayu; Asaoka, Yoshiji; Miyamoto, Yohei; Oshida, Keiyu

    2017-10-05

    The murine local lymph node assay (LLNA) is widely used to test chemicals to induce skin sensitization. Exposure of mouse auricle skin to a sensitizer results in proliferation of local lymph node T cells, which has been measured by in vivo incorporation of H 3 -methyl thymidine or 5-bromo-2'-deoxyuridine (BrdU). The stimulation index (SI), the ratio of the mean proliferation in each treated group to that in the concurrent vehicle control group, is frequently used as a regulatory-authorized endpoint for LLNA. However, some non-sensitizing irritants, such as sodium dodecyl sulfate (SDS) or methyl salicylate (MS), have been reported as false-positives by this endpoint. In search of a potential endpoint to enhance the specificity of existing endpoints, we evaluated 3 contact sensitizers; (hexyl cinnamic aldehyde [HCA], oxazolone [OXA], and 2,4-dinitrochlorobenzene [DNCB]), 1 respiratory sensitizer (toluene 2,4-diisocyanate [TDI]), and 2 non-sensitizing irritants (MS and SDS) by several endpoints in LLNA. Each test substance was applied to both ears of female CBA/Ca mice daily for 3 consecutive days. The ears and auricle lymph node cells were analyzed on day 5 for endpoints including the SI value, lymph node cell count, cytokine release from lymph node cells, and histopathological changes and gene expression profiles in auricle skin. The SI values indicated that all the test substances induced significant proliferation of lymph node cells. The lymph node cell counts showed no significant changes by the non-sensitizers assessed. The inflammatory findings of histopathology were similar among the auricle skins treated by sensitizers and irritants. Gene expression profiles of cytokines IFN-γ, IL-4, and IL-17 in auricle skin were similar to the cytokine release profiles in draining lymph node cells. In addition, the gene expression of the chemokine CXCL1 and/or CXCL2 showed that it has the potential to discriminate sensitizers and non-sensitizing irritants. Our results

  9. Electrodynamics at the highest energies

    International Nuclear Information System (INIS)

    Klein, Spencer R.

    2002-01-01

    At very high energies, the bremsstrahlung and pair production cross sections exhibit complex behavior due to the material in which the interactions occur. The cross sections in dense media can be dramatically different than for isolated atoms. This writeup discusses these in-medium effects, emphasizing how the cross section has different energy and target density dependencies in different regimes. Data from SLAC experiment E-146 will be presented to confirm the energy and density scaling. Finally, QCD analogs of the electrodynamics effects will be discussed

  10. Endpoint behavior of the pion distribution amplitude in QCD sum rules with nonlocal condensates

    International Nuclear Information System (INIS)

    Mikhailov, S. V.; Pimikov, A. V.; Stefanis, N. G.

    2010-01-01

    Starting from the QCD sum rules with nonlocal condensates for the pion distribution amplitude, we derive another sum rule for its derivative and its ''integral derivatives''--defined in this work. We use this new sum rule to analyze the fine details of the pion distribution amplitude in the endpoint region x∼0. The results for endpoint-suppressed and flattop (or flatlike) pion distribution amplitudes are compared with those we obtained with differential sum rules by employing two different models for the distribution of vacuum-quark virtualities. We determine the range of values of the derivatives of the pion distribution amplitude and show that endpoint-suppressed distribution amplitudes lie within this range, while those with endpoint enhancement--flat-type or Chernyak-Zhitnitsky like--yield values outside this range.

  11. 78 FR 49530 - Gastroenterology Regulatory Endpoints and the Advancement of Therapeutics; Public Workshop

    Science.gov (United States)

    2013-08-14

    ...] Gastroenterology Regulatory Endpoints and the Advancement of Therapeutics; Public Workshop AGENCY: Food and Drug... for Drug Evaluation and Research, in cosponsorship with the American College of Gastroenterology, the... American Society for Pediatric Gastroenterology, Hepatology, and Nutrition, and the Pediatric IBD...

  12. On weighted hardy inequalities on semiaxis for functions vanishing at the endpoints

    Directory of Open Access Journals (Sweden)

    Stepanov Vladimir

    1997-01-01

    Full Text Available We study the weighted Hardy inequalities on the semiaxis of the form for functions vanishing at the endpoints together with derivatives up to the order . The case is completely characterized.

  13. 76 FR 51993 - Draft Guidance for Industry on Standards for Clinical Trial Imaging Endpoints; Availability

    Science.gov (United States)

    2011-08-19

    ... clinical trials of therapeutic drugs and biological products. The draft guidance describes standards... important imaging endpoint is used in a clinical trial of a therapeutic drug or biological product... Services to the Chairman of [[Page 51994

  14. Reporting and evaluation of HIV-related clinical endpoints in two multicenter international clinical trials

    DEFF Research Database (Denmark)

    Lifson, A; Rhame, F; Bellosa, W

    2006-01-01

    adjudication between reviewers before diagnostic certainty was assigned. CONCLUSION: Important requirements for HIV trials using clinical endpoints include objective definitions of "confirmed" and "probable," a formal reporting process with adequate information and supporting source documentation, evaluation......PURPOSE: The processes for reporting and review of progression of HIV disease clinical endpoints are described for two large phase III international clinical trials. METHOD: SILCAAT and ESPRIT are multicenter randomized HIV trials evaluating the impact of interleukin-2 on disease progression...... and death in HIV-infected patients receiving antiretroviral therapy. We report definitions used for HIV progression of disease endpoints, procedures for site reporting of such events, processes for independent review of reported events by an Endpoint Review Committee (ERC), and the procedure...

  15. Hard photons beyond proton-neutron Bremsstrahlung in heavy-ion collisions

    International Nuclear Information System (INIS)

    Gudima, K.; Ploszajczak, M.

    1998-01-01

    The study of extremely high energy photons, pions and etas, produced in intermediate energy heavy-ion collisions is presented. Possibility of imaging the final-state phase space in these collisions by the Bose-Einstein correlations for photons is critically examined. (author)

  16. SpEnD: Linked Data SPARQL Endpoints Discovery Using Search Engines

    OpenAIRE

    Yumusak, Semih; Dogdu, Erdogan; Kodaz, Halife; Kamilaris, Andreas

    2016-01-01

    In this study, a novel metacrawling method is proposed for discovering and monitoring linked data sources on the Web. We implemented the method in a prototype system, named SPARQL Endpoints Discovery (SpEnD). SpEnD starts with a "search keyword" discovery process for finding relevant keywords for the linked data domain and specifically SPARQL endpoints. Then, these search keywords are utilized to find linked data sources via popular search engines (Google, Bing, Yahoo, Yandex). By using this ...

  17. Energy

    International Nuclear Information System (INIS)

    Meister, F.; Ott, F.

    2002-01-01

    This chapter gives an overview of the current energy economy in Austria. The Austrian political aims of sustainable development and climate protection imply a reorientation of the Austrian energy policy as a whole. Energy consumption trends (1993-1998), final energy consumption by energy carrier (indexed data 1993-1999), comparative analysis of useful energy demand (1993 and 1999) and final energy consumption of renewable energy sources by sector (1996-1999) in Austria are given. The necessary measures to be taken in order to reduce the energy demand and increased the use of renewable energy are briefly mentioned. Figs. 5. (nevyjel)

  18. The use of intermediate endpoints in the design of type 1 diabetes prevention trials.

    Science.gov (United States)

    Krischer, Jeffrey P

    2013-09-01

    This paper presents a rationale for the selection of intermediate endpoints to be used in the design of type 1 diabetes prevention clinical trials. Relatives of individuals diagnosed with type 1 diabetes were enrolled on the TrialNet Natural History Study and screened for diabetes-related autoantibodies. Those with two or more such autoantibodies were analysed with respect to increased HbA1c, decreased C-peptide following an OGTT, or abnormal OGTT values as intermediate markers of disease progression. Over 2 years, a 10% increase in HbA1c, and a 20% or 30% decrease in C-peptide from baseline, or progression to abnormal OGTT, occurred with a frequency between 20% and 41%. The 3- to 5-year risk of type 1 diabetes following each intermediate endpoint was high, namely 47% to 84%. The lower the incidence of the endpoint being reached, the higher the risk of diabetes. A diabetes prevention trial using these intermediate endpoints would require a 30% to 50% smaller sample size than one using type 1 diabetes as the endpoint. The use of an intermediate endpoint in diabetes prevention is based on the generally held view of disease progression from initial occurrence of autoantibodies through successive immunological and metabolic changes to manifest type 1 diabetes. Thus, these markers are suitable for randomised phase 2 trials, which can more rapidly screen promising new therapies, allowing them to be subsequently confirmed in definitive phase 3 trials.

  19. Development of Cardiovascular and Neurodevelopmental Metrics as Sublethal Endpoints for the Fish Embryo Toxicity Test.

    Science.gov (United States)

    Krzykwa, Julie C; Olivas, Alexis; Jeffries, Marlo K Sellin

    2018-06-19

    The fathead minnow fish embryo toxicity (FET) test has been proposed as a more humane alternative to current toxicity testing methods, as younger organisms are thought to experience less distress during toxicant exposure. However, the FET test protocol does not include endpoints that allow for the prediction of sublethal adverse outcomes, limiting its utility relative to other test types. Researchers have proposed the development of sublethal endpoints for the FET test to increase its utility. The present study 1) developed methods for previously unmeasured sublethal metrics in fathead minnows (i.e., spontaneous contraction frequency and heart rate) and 2) investigated the responsiveness of several sublethal endpoints related to growth (wet weight, length, and growth-related gene expression), neurodevelopment (spontaneous contraction frequency, and neurodevelopmental gene expression), and cardiovascular function and development (pericardial area, eye size and cardiovascular related gene expression) as additional FET test metrics using the model toxicant 3,4-dichloroaniline. Of the growth, neurological and cardiovascular endpoints measured, length, eye size and pericardial area were found to more responsive than the other endpoints, respectively. Future studies linking alterations in these endpoints to longer-term adverse impacts are needed to fully evaluate the predictive power of these metrics in chemical and whole effluent toxicity testing. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  20. Energy

    International Nuclear Information System (INIS)

    Meister, F.

    2001-01-01

    This chapter of the environmental control report deals with the environmental impact of energy production, energy conversion, atomic energy and renewable energy. The development of the energy consumption in Austria for the years 1993 to 1999 is given for the different energy types. The development of the use of renewable energy sources in Austria is given, different domestic heat-systems are compared, life cycles and environmental balance are outlined. (a.n.)

  1. Five criteria for using a surrogate endpoint to predict treatment effect based on data from multiple previous trials.

    Science.gov (United States)

    Baker, Stuart G

    2018-02-20

    A surrogate endpoint in a randomized clinical trial is an endpoint that occurs after randomization and before the true, clinically meaningful, endpoint that yields conclusions about the effect of treatment on true endpoint. A surrogate endpoint can accelerate the evaluation of new treatments but at the risk of misleading conclusions. Therefore, criteria are needed for deciding whether to use a surrogate endpoint in a new trial. For the meta-analytic setting of multiple previous trials, each with the same pair of surrogate and true endpoints, this article formulates 5 criteria for using a surrogate endpoint in a new trial to predict the effect of treatment on the true endpoint in the new trial. The first 2 criteria, which are easily computed from a zero-intercept linear random effects model, involve statistical considerations: an acceptable sample size multiplier and an acceptable prediction separation score. The remaining 3 criteria involve clinical and biological considerations: similarity of biological mechanisms of treatments between the new trial and previous trials, similarity of secondary treatments following the surrogate endpoint between the new trial and previous trials, and a negligible risk of harmful side effects arising after the observation of the surrogate endpoint in the new trial. These 5 criteria constitute an appropriately high bar for using a surrogate endpoint to make a definitive treatment recommendation. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.

  2. Stimulated bremsstrahlung of soft x-ray in a longitudinal undulating electric field

    International Nuclear Information System (INIS)

    Kim, S.H.

    1991-01-01

    It is shown that a high-energy electron beam injected into a longitudinal undulating electric field (electric undulator) in the field direction can emit a laser light in the field direction through both stimulated and unstimulated free-electron two-quantum Stark emission. Based on the momentum and energy conservation laws and the time-reversal invariance of the transition probability, a new quantum kinetic equation for the net energy transfer from an electron to the laser wave is derived. By using this equation, the photon concept, and the transition probability calculated by the Dirac equation, the gain spectrum and wavelength of the free-electron laser using the electric undulator are derived. The gain appears to scale as the inverse of the electron beam energy and the cube of the wavelength of the electric undulator

  3. A web-based endpoint adjudication system for interim analyses in clinical trials.

    Science.gov (United States)

    Nolen, Tracy L; Dimmick, Bill F; Ostrosky-Zeichner, Luis; Kendrick, Amy S; Sable, Carole; Ngai, Angela; Wallace, Dennis

    2009-02-01

    A data monitoring committee (DMC) is often employed to assess trial progress and review safety data and efficacy endpoints throughout a trail. Interim analyses performed for the DMC should use data that are as complete and verified as possible. Such analyses are complicated when data verification involves subjective study endpoints or requires clinical expertise to determine each subject's status with respect to the study endpoint. Therefore, procedures are needed to obtain adjudicated data for interim analyses in an efficient manner. In the past, methods for handling such data included using locally reported results as surrogate endpoints, adjusting analysis methods for unadjudicated data, or simply performing the adjudication as rapidly as possible. These methods all have inadequacies that make their sole usage suboptimal. For a study of prophylaxis for invasive candidiasis, adjudication of both study eligibility criteria and clinical endpoints prior to two interim analyses was required. Because the study was expected to enroll at a moderate rate and the sponsor required adjudicated endpoints to be used for interim analyses, an efficient process for adjudication was required. We created a web-based endpoint adjudication system (WebEAS) that allows for expedited review by the endpoint adjudication committee (EAC). This system automatically identifies when a subject's data are complete, creates a subject profile from the study data, and assigns EAC reviewers. The reviewers use the WebEAS to review the subject profile and submit their completed review form. The WebEAS then compares the reviews, assigns an additional review as a tiebreaker if needed, and stores the adjudicated data. The study for which this system was originally built was administratively closed after 10 months with only 38 subjects enrolled. The adjudication process was finalized and the WebEAS system activated prior to study closure. Some website accessibility issues presented initially. However

  4. Energy loss of muons in the energy range 1-10000 GeV

    International Nuclear Information System (INIS)

    Lohmann, W.; Kopp, R.; Voss, R.

    1985-01-01

    A summary is given of the most recent formulae for the cross-sections contributing to the energy loss of muons in matter, notably due to electro-magnetic interactions (ionization, bremsstrahlung and electron-pair production) and nuclear interactions. Computed energy losses dE/dx are tabulated for muons with energy between 1 GeV and 10,000 GeV in a number of materials commonly used in high-energy physics experiments. In comparison with earlier tables, these show deviations that grow with energy and amount to several per cent at 200 GeV muon energy. (orig.)

  5. Performance costs of cryptography in securing new-generation Internet of Energy endpoint devices

    CSIR Research Space (South Africa)

    Ledwaba, Lehlogonolo PI

    2017-11-01

    Full Text Available cryptographic services on wireless sensor nodes have resulted in high power consumptions, long operating times and the depletion of memory resources. Over the last decade, however, processors for the IoT and IoE have improved; with increased operating power...

  6. Measurement of continuous x-radiation and determination of the energy distribution function of high-energy electrons from an ECR plasma

    International Nuclear Information System (INIS)

    Bernhardi, K.

    1980-01-01

    Investigations were made on the x-radiation emitted by a plasma. The methods applied here represent a further development of experimental and numerical methods used hitherto for determining the bremsstrahlung emitted by a plasma, and makes possible a more precise determination of the high-energy electron component of a plasma

  7. Comparing three novel endpoints for developmental osteotoxicity in the embryonic stem cell test

    International Nuclear Information System (INIS)

    Nieden, Nicole I. zur; Davis, Lesley A.; Rancourt, Derrick E.

    2010-01-01

    Birth defects belong to the most serious side effects of pharmaceutical compounds or environmental chemicals. In vivo, teratogens most often affect the normal development of bones, causing growth retardation, limb defects or craniofacial malformations. The embryonic stem cell test (EST) is one of the most promising models that allow the in vitro prediction of embryotoxicity, with one of its endpoints being bone tissue development. The present study was designed to describe three novel inexpensive endpoints to assess developmental osteotoxicity using the model compounds penicillin G (non-teratogenic), 5-fluorouracil (strong teratogen) and all-trans retinoic acid (bone teratogen). These three endpoints were: quantification of matrix incorporated calcium by (1) morphometric analysis and (2) measurement of calcium levels as well as (3) activity of alkaline phosphatase, an enzyme involved in matrix calcification. To evaluate our data, we have compared the concentration curves and resulting ID 50 s of the new endpoints with mRNA expression for osteocalcin. Osteocalcin is an exclusive marker found only in mineralized tissues, is regulated upon compound treatment and reliably predicts the potential of a chemical entity acting as a bone teratogen. By comparing the new endpoints to quantitative expression of osteocalcin, which we previously identified as suitable to detect developmental osteotoxicity, we were ultimately able to illustrate IMAGE analysis and Ca 2+ deposition assays as two reliable novel endpoints for the EST. This is of particular importance for routine industrial assessment of novel compounds as these two new endpoints may substitute previously used molecular read-out methods, which are often costly and time-consuming.

  8. Measurement of {sup 27}Al(γ,2pn){sup 24}Na Reaction Cross-sections with 55 -, 60 -, 65 - MeV Bremsstrahlung Employing MCNPX Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Shin, S. G.; Kye, Y.; Cho, M. H. [POSTECH, Pohang (Korea, Republic of); Namkung, W. [Pohang Accelerator Laboratory, Pohang (Korea, Republic of); KIm, G. N.; Kim, K. [Kyungpook National Univ., Daegu (Korea, Republic of); Lee, M. W.; Kang, Y. R. [Dongnam Inst. Of Radiological and Medical Science, Busan (Korea, Republic of)

    2014-05-15

    Aluminum is used for monitoring the photon flux. The photon flux during the activation can be measured by substituting the {sup 27}Al(γ,2pn){sup 24}Na reaction cross-section induced by bremsstrahlung to reactivity equation. Therefore, if this cross-section is more accurate, gamma-ray flux can be measure more accurately. In this work, the {sup 27}Al(γ,2pn){sup 24}Na reaction cross-sections induced by 55 - 65 MeV bremsstrahlung were measured by activation technique at the Pohang Neutron Facility (PNF) which has produced the nuclear data using Time-Of-Flight method and activation technique. In order to get the photon flux, MCNPX was used. These measurement values were compared with the data of Meyer et al (1968)

  9. Influence of the electron cyclotron resonance plasma confinement on reducing the bremsstrahlung production of an electron cyclotron resonance ion source with metal-dielectric structures.

    Science.gov (United States)

    Schachter, L; Stiebing, K E; Dobrescu, S

    2009-01-01

    The influence of metal-dielectric (MD) layers (MD structures) inserted into the plasma chamber of an electron cyclotron resonance ion source (ECRIS) onto the production of electron bremsstrahlung radiation has been studied in a series of dedicated experiments at the 14 GHz ECRIS of the Institut für Kernphysik der Universität Frankfurt. The IKF-ECRIS was equipped with a MD liner, covering the inner walls of the plasma chamber, and a MD electrode, covering the plasma-facing side of the extraction electrode. On the basis of similar extracted currents of highly charged ions, significantly reduced yields of bremsstrahlung radiation for the "MD source" as compared to the standard (stainless steel) source have been measured and can be explained by the significantly better plasma confinement in a MD source as compared to an "all stainless steel" ECRIS.

  10. Influence of the electron cyclotron resonance plasma confinement on reducing the bremsstrahlung production of an electron cyclotron resonance ion source with metal-dielectric structures

    International Nuclear Information System (INIS)

    Schachter, L.; Dobrescu, S.; Stiebing, K. E.

    2009-01-01

    The influence of metal-dielectric (MD) layers (MD structures) inserted into the plasma chamber of an electron cyclotron resonance ion source (ECRIS) onto the production of electron bremsstrahlung radiation has been studied in a series of dedicated experiments at the 14 GHz ECRIS of the Institut fuer Kernphysik der Universitaet Frankfurt. The IKF-ECRIS was equipped with a MD liner, covering the inner walls of the plasma chamber, and a MD electrode, covering the plasma-facing side of the extraction electrode. On the basis of similar extracted currents of highly charged ions, significantly reduced yields of bremsstrahlung radiation for the 'MD source' as compared to the standard (stainless steel) source have been measured and can be explained by the significantly better plasma confinement in a MD source as compared to an ''all stainless steel'' ECRIS.

  11. Energy

    International Nuclear Information System (INIS)

    Bobin, J.L.

    1996-01-01

    Object of sciences and technologies, energy plays a major part in economics and relations between nations. Jean-Louis Bobin, physicist, analyses the relations between man and energy and wonders about fears that delivers nowadays technologies bound to nuclear energy and about the fear of a possible shortage of energy resources. (N.C.). 17 refs., 14 figs., 2 tabs

  12. Determining significant endpoints for ecological risk analyses. 1998 annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Hinton, T.G.; Congdon, J.; Scott, D. [Univ. of Georgia, Aiken, SC (US). Savannah River Ecology Lab.; Rowe, C. [Univ. of Puerto Rico, San Juan (PR); Bedford, J.; Whicker, W. [Colorado State Univ., Fort Collins, CO (US)

    1998-06-01

    'The goal of this report is to establish a protocol for assessing risks to non-human populations exposed to environmental stresses typically found on many DOE sites. The authors think that they can achieve this by using novel biological dosimeters in controlled, manipulative dose/effects experiments, and by coupling changes in metabolic rates and energy allocation patterns to meaningful population response variables (such as age-specific survivorship, reproductive output, age at maturity and longevity). This research is needed to determine the relevancy of sublethal cellular damage to the performance of individuals and populations exposed to chronic, low-level radiation, and radiation with concomitant exposure to chemicals. They believe that a scientifically defensible endpoint for measuring ecological risks can only be determined once its understood the extent to which molecular damage from contaminant exposure is detrimental at the individual and population levels of biological organization. The experimental facility will allow them to develop a credible assessment tool for appraising ecological risks, and to evaluate the effects of radionuclide/chemical synergisms on non-human species. This report summarizes work completed midway of a 3-year project that began in November 1996. Emphasis to date has centered on three areas: (1) developing a molecular probe to measure stable chromosomal aberrations known as reciprocal translocations, (2) constructing an irradiation facility where the statistical power inherent in replicated mesocosms can be used to address the response of non-human organisms to exposures from low levels of radiation and metal contaminants, and (3) quantifying responses of organisms living in contaminated mesocosms and field sites.'

  13. Energy

    CERN Document Server

    Foland, Andrew Dean

    2007-01-01

    Energy is the central concept of physics. Unable to be created or destroyed but transformable from one form to another, energy ultimately determines what is and isn''t possible in our universe. This book gives readers an appreciation for the limits of energy and the quantities of energy in the world around them. This fascinating book explores the major forms of energy: kinetic, potential, electrical, chemical, thermal, and nuclear.

  14. Endpoint in plasma etch process using new modified w-multivariate charts and windowed regression

    Science.gov (United States)

    Zakour, Sihem Ben; Taleb, Hassen

    2017-09-01

    Endpoint detection is very important undertaking on the side of getting a good understanding and figuring out if a plasma etching process is done in the right way, especially if the etched area is very small (0.1%). It truly is a crucial part of supplying repeatable effects in every single wafer. When the film being etched has been completely cleared, the endpoint is reached. To ensure the desired device performance on the produced integrated circuit, the high optical emission spectroscopy (OES) sensor is employed. The huge number of gathered wavelengths (profiles) is then analyzed and pre-processed using a new proposed simple algorithm named Spectra peak selection (SPS) to select the important wavelengths, then we employ wavelet analysis (WA) to enhance the performance of detection by suppressing noise and redundant information. The selected and treated OES wavelengths are then used in modified multivariate control charts (MEWMA and Hotelling) for three statistics (mean, SD and CV) and windowed polynomial regression for mean. The employ of three aforementioned statistics is motivated by controlling mean shift, variance shift and their ratio (CV) if both mean and SD are not stable. The control charts show their performance in detecting endpoint especially W-mean Hotelling chart and the worst result is given by CV statistic. As the best detection of endpoint is given by the W-Hotelling mean statistic, this statistic will be used to construct a windowed wavelet Hotelling polynomial regression. This latter can only identify the window containing endpoint phenomenon.

  15. Bioremediation of hydrocarbon-contaminated soils: are treatability and ecotoxicity endpoints related?

    International Nuclear Information System (INIS)

    Visser, S.

    1999-01-01

    To determine if there is a relationship between biotreatability and ecotoxicity endpoints in a wide range of hydrocarbon-contaminated soils, including medium and heavy crude oil-contaminated flare pit wastes and lubrication oil contaminated soil, research was conducted. Each test material was analyzed for pH, water repellency, electrical conductivity, available N and P, total extractable hydrocarbons, oil and grease, and toxicity to seedling emergence, root elongation in barley, lettuce and canola, earthworm survival and luminescent bacteria (Microtox), prior to, and following three months of bioremediation in the laboratory. By monitoring soil respiration, progress of the bioremediation process and determination of a treatment endpoint were assessed. The time required to attain a treatment endpoint under laboratory conditions can range from 30 days to 100 days depending on the concentration of hydrocarbons and degree of weathering. Most flare pits are biotreatable, averaging a loss of 25-30% of hydrocarbons during bioremediation. Once a treatment endpoint is achieved, residual hydrocarbons contents almost always exceeds Alberta Tier I criteria for mineral oil and grease. As a result of bioremediation treatments, hydrophobicity is often reduced from severe to low. Many flare pit materials are still moderately to extremely toxic after reaching a treatment endpoint. (Abstract only)

  16. Multi-Toxic Endpoints of the Foodborne Mycotoxins in Nematode Caenorhabditis elegans

    Directory of Open Access Journals (Sweden)

    Zhendong Yang

    2015-12-01

    Full Text Available Aflatoxins B1 (AFB1, deoxynivalenol (DON, fumonisin B1 (FB1, T-2 toxin (T-2, and zearalenone (ZEA are the major foodborne mycotoxins of public health concerns. In the present study, the multiple toxic endpoints of these naturally-occurring mycotoxins were evaluated in Caenorhabditis elegans model for their lethality, toxic effects on growth and reproduction, as well as influence on lifespan. We found that the lethality endpoint was more sensitive for T-2 toxicity with the EC50 at 1.38 mg/L, the growth endpoint was relatively sensitive for AFB1 toxic effects, and the reproduction endpoint was more sensitive for toxicities of AFB1, FB1, and ZEA. Moreover, the lifespan endpoint was sensitive to toxic effects of all five tested mycotoxins. Data obtained from this study may serve as an important contribution to knowledge on assessment of mycotoxin toxic effects, especially for assessing developmental and reproductive toxic effects, using the C. elegans model.

  17. Pollutant threshold concentration determination in marine ecosystems using an ecological interaction endpoint.

    Science.gov (United States)

    Wang, Changyou; Liang, Shengkang; Guo, Wenting; Yu, Hua; Xing, Wenhui

    2015-09-01

    The threshold concentrations of pollutants are determined by extrapolating single-species effect data to community-level effects. This assumes the most sensitive endpoint of the life cycle of individuals and the species sensitivity distribution from single-species toxic effect tests, thus, ignoring the ecological interactions. The uncertainties due to this extrapolation can be partially overcome using the equilibrium point of a customized ecosystem. This method incorporates ecological interactions and integrates the effects on growth, survival, and ingestion into a single effect measure, the equilibrium point excursion in the customized ecosystem, in order to describe the toxic effects on plankton. A case study showed that the threshold concentration of copper calculated with the endpoint of the equilibrium point was 10 μg L(-1), which is significantly different from the threshold calculated with a single-species endpoint. The endpoint calculated using this method provides a more relevant measure of the ecological impact than any single individual-level endpoint. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Measurement assurance studies of high-energy electron and photon dosimetry in radiation-therapy applications

    Energy Technology Data Exchange (ETDEWEB)

    Ehrlich, M; Soares, C G [National Bureau of Standards, Washington, DC (USA)

    1981-08-01

    This is a brief review of surveys on the dosimetry of radiation-therapy beams by the National Bureau of Standards (NBS). Covered are the NBS ferrous-sulfate (Fricke) dosimetry service, a recently completed survey carried out with thermoluminescence dosimeters (TLD) on the dosimetry in cobalt-60 teletherapy beams, and plans for a TLD survey of dosimetry in high-energy bremsstrahlung beams.

  19. A comparison of experiment, CEPXS/ONETRAN, TIGERP, and QUICKE2 net electron emission coefficients for various bremsstrahlung spectra

    International Nuclear Information System (INIS)

    Ballard, W.P.; Lorence, L.J. Jr.; Snowden, D.P.; van Lint, V.A.J.; Beale, E.S.

    1987-01-01

    This work compares a carefully designed experiment with the predictions of four different codes (CEPXS/ONETRAN, TIGERP, TIGER and QUICKE2) for the complex bremsstrahlung spectra typical of very intense pulsed power x-ray generators. Accurate calculation of net photon-induced electron emission yields at material interfaces using Monte Carlo codes can be particularly difficult if the forward and reverse partial yields are of similar magnitudes. In such a circumstance, the statistical error in the Monte Carlo solution (TIGER or TIGERP) must be kept to a minimum to accurately resolve the difference. CEPXS/ONETRAN is a new deterministic coupled electron/photon transport code that is faster than Monte Carlo and is not subject to statistical error. QUICKE2 evaluates an analytical approximation and is also much less expensive to run than the Monte Carlo codes. The comparison of net yields is a sensitive test of the relative accuracy and efficiency of these various codes. We find that all of the codes except QUICKE2 substantially agree with the experiments for the forward net yields. Howver, for reverse net yields from high-Z materials, all the codes overpredict relative to measurements

  20. Gamma rays made on Earth have unexpectedly high energies

    International Nuclear Information System (INIS)

    Miller, Johanna

    2011-01-01

    Terrestrial gamma-ray flashes (TGFs) are the source of the highest-energy nonanthropogenic photons produced on Earth. Associated with thunder-storms - and in fact, with individual lightning discharges - they are presumed to be the bremsstrahlung produced when relativistic electrons, accelerated by the storms' strong electric fields, collide with air molecules some 10-20 km above sea level. The TGFs last up to a few milliseconds and contain photons with energies on the order of MeV.