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Sample records for end effects

  1. Proportional counter end effects eliminator

    Meekins, J.F.

    1976-01-01

    An improved gas-filled proportional counter which includes a resistor network connected between the anode and cathode at the ends of the counter in order to eliminate ''end effects'' is described. 3 Claims, 2 Drawing Figures

  2. The effectiveness of sharp end and rounded end bristle toothbrush

    Paulus Januar; Anastasia Susetyo; Ratih Widyastuti

    2010-01-01

    Background: Numerous designs of manual toothbrush are available in the market with the claims of superiority in plaque removal. It often makes the public confuse which is the best design. The sharp end bristle toothbrush is a modification that commercially available in the market. Purpose: The objective of the study was to compare the effectiveness in plaque removal of the sharp end bristle toothbrush and the rounded end bristle toothbrush. Methods: This clinical trial was a double blind cros...

  3. Role of end effects in helical aggregation

    Gestel, van J.A.M.; Schoot, van der P.P.A.M.; Michels, M.A.J.

    2003-01-01

    End effects are known to play a pivotal role in equilibrium polymerization. To investigate their role in detail, we apply constraints to the first and last bonds of model linear aggregates that exhibit a helix-coil type configurational transition. Three different classes of behavior manifest

  4. END FIELD EFFECTS IN BEND ONLY COOLING LATTICES

    BEERG, J.S.; KIRK, H.; GARREN, A.

    2003-01-01

    Cooling lattices consisting only of bends (using either rotated pole faces or gradient dipoles to achieve focusing) often require large apertures and short magnets. One expects the effect of end fields to be significant in this case. In this paper we explore the effect of adding end fields to a working lattice design that originally lacked them. The paper describes the process of correcting the lattice design for the added end fields so as to maintain desirable lattice characteristics. It then compares the properties of the lattice with end fields relative to the lattice without them

  5. End effects on elbows subjected to moment loadings

    Rodabaugh, E.C.; Moore, S.E.

    1982-01-01

    So-called end effects for moment loadings on short-radius and long-radius butt welding elbows of various arc lengths are investigated with a view toward providing more accurate design formulas for critical piping systems. Data developed in this study, along with published information, were used to develop relatively simple design equations for elbows attached at both ends to long sections of straight pipe. These formulas are the basis for an alternate ASME Code procedure for evaluating the bending moment stresses in Class 1 nuclear piping (ASME Code Case N-319). The more complicated problems of elbows with other end conditions, e.g., flanges at one or both ends, are also considered. Comparisons of recently published experimental and theoretical studies with current industrial code design rules for these situations indicate that these rules also need to be improved

  6. The end-state comfort effect in bimanual grip selection.

    Fischman, Mark G; Stodden, David F; Lehman, Davana M

    2003-03-01

    During a unimanual grip selection task in which people pick up a lightweight dowel and place one end against targets at variable heights, the choice of hand grip (overhand vs. underhand) typically depends on the perception of how comfortable the arm will be at the end of the movement: an end-state comfort effect. The two experiments reported here extend this work to bimanual tasks. In each experiment, 26 right-handed participants used their left and right hands to simultaneously pick up two wooden dowels and place either the right or left end against a series of 14 targets ranging from 14 to 210 cm above the floor. These tasks were performed in systematic ascending and descending orders in Experiment 1 and in random order in Expiment 2. Results were generally consistent with predictions of end-state comfort in that, for the extreme highest and lowest targets, participants tended to select opposite grips with each hand. Taken together, our findings are consistent with the concept of constraint hierarchies within a posture-based motion-planning model.

  7. End effects on elbows subjected to moment loadings

    Rodabaugh, E.C.; Iskander, S.K.; Moore, S.E.

    1978-03-01

    End effects on elbows subjected to moment loading are investigated using the finite element program EPACA. Relatively simple but more accurate (than present Code) equations are developed and recommendation for an alternative Code method using these equations is presented. Data from EPACA on stresses at welds (elbow-to-pipe juncture) are presented. A simple equation is given for estimating the maximum stresses at the welds

  8. Effects of positive end-expiratory pressure on renal function.

    Järnberg, P O; de Villota, E D; Eklund, J; Granberg, P O

    1978-01-01

    The effects were studied positive end-expiratory pressure (PEEP) on renal function in eight patients with acute respiratory failure, requiring mechanical ventilation. On application of PEEP + 10 cm H2O, central venous pressure increased, systolic blood pressure decreased, urine flow and PAH-clearance were reduced, while inulin clearance remained stable. There was a marked increase in fractional sodium reabsorption and a concurrent decrease in fractional osmolal excretion. Fractional free-water clearance and the ratio UOsm/POsm did change.

  9. The effective QCD phase diagram and the critical end point

    Alejandro Ayala

    2015-08-01

    Full Text Available We study the QCD phase diagram on the temperature T and quark chemical potential μ plane, modeling the strong interactions with the linear sigma model coupled to quarks. The phase transition line is found from the effective potential at finite T and μ taking into account the plasma screening effects. We find the location of the critical end point (CEP to be (μCEP/Tc,TCEP/Tc∼(1.2,0.8, where Tc is the (pseudocritical temperature for the crossover phase transition at vanishing μ. This location lies within the region found by lattice inspired calculations. The results show that in the linear sigma model, the CEP's location in the phase diagram is expectedly determined solely through chiral symmetry breaking. The same is likely to be true for all other models which do not exhibit confinement, provided the proper treatment of the plasma infrared properties for the description of chiral symmetry restoration is implemented. Similarly, we also expect these corrections to be substantially relevant in the QCD phase diagram.

  10. Understanding Effect of Constraint Release Environment on End-to-End Vector Relaxation of Linear Polymer Chains

    Shivokhin, Maksim E.

    2017-05-30

    We propose and verify methods based on the slip-spring (SSp) model [ Macromolecules 2005, 38, 14 ] for predicting the effect of any monodisperse, binary, or ternary environment of topological constraints on the relaxation of the end-to-end vector of a linear probe chain. For this purpose we first validate the ability of the model to consistently predict both the viscoelastic and dielectric response of monodisperse and binary mixtures of type A polymers, based on published experimental data. We also report the synthesis of new binary and ternary polybutadiene systems, the measurement of their linear viscoelastic response, and the prediction of these data by the SSp model. We next clarify the relaxation mechanisms of probe chains in these constraint release (CR) environments by analyzing a set of "toy" SSp models with simplified constraint release rates, by examining fluctuations of the end-to-end vector. In our analysis, the longest relaxation time of the probe chain is determined by a competition between the longest relaxation times of the effective CR motions of the fat and thin tubes and the motion of the chain itself in the thin tube. This picture is tested by the analysis of four model systems designed to separate and estimate every single contribution involved in the relaxation of the probe\\'s end-to-end vector in polydisperse systems. We follow the CR picture of Viovy et al. [ Macromolecules 1991, 24, 3587 ] and refine the effective chain friction in the thin and fat tubes based on Read et al. [ J. Rheol. 2012, 56, 823 ]. The derived analytical equations form a basis for generalizing the proposed methodology to polydisperse mixtures of linear and branched polymers. The consistency between the SSp model and tube model predictions is a strong indicator of the compatibility between these two distinct mesoscopic frameworks.

  11. Effect of dietary advanced glycation end products on mouse liver.

    Raza Patel

    Full Text Available UNLABELLED: The exact pathophysiology of non-alcoholic steatohepatitis (NASH is not known. Previous studies suggest that dietary advanced glycation end products (AGEs can cause oxidative stress in liver. We aim to study the effects of dietary AGEs on liver health and their possible role in the pathogenesis of NASH. METHODS: Two groups of mice were fed the same diet except the AGE content varied. One group was fed a high AGE diet and the second group was fed a regular AGE diet. Liver histology, alanine aminotransferase, aspartate aminotransferase, fasting glucose, fasting insulin, insulin resistance and glucose tolerance were assessed. RESULTS: Histology revealed that neutrophil infiltration occurred in the livers of the high AGE group at week 26; steatosis did not accompany liver inflammation. At week 39 livers from both groups exhibited macro- or micro-steatosis, yet no inflammation was detected. Higher insulin levels were detected in the regular AGE group at week 26 (P = 0.034, compared to the high AGE group. At week 39, the regular AGE group showed higher levels of alanine aminotransferase (P<0.01 and aspartate aminotransferase (P = 0.02 than those of the high AGE group. CONCLUSIONS: We demonstrate that a high AGE diet can cause liver inflammation in the absence of steatosis. Our results show that dietary AGEs could play a role in initiating liver inflammation contributing to the disease progression of NASH. Our observation that the inflammation caused by high AGE alone did not persist suggests interesting future directions to investigate how AGEs contribute to pro-oxidative and anti-oxidative pathways in the liver.

  12. Effect of 3 Key Factors on Average End to End Delay and Jitter in MANET

    Saqib Hakak

    2015-01-01

    Full Text Available A mobile ad-hoc network (MANET is a self-configuring infrastructure-less network of mobile devices connected by wireless links where each node or mobile device is independent to move in any desired direction and thus the links keep moving from one node to another. In such a network, the mobile nodes are equipped with CSMA/CA (carrier sense multiple access with collision avoidance transceivers and communicate with each other via radio. In MANETs, routing is considered one of the most difficult and challenging tasks. Because of this, most studies on MANETs have focused on comparing protocols under varying network conditions. But to the best of our knowledge no one has studied the effect of other factors on network performance indicators like throughput, jitter and so on, revealing how much influence a particular factor or group of factors has on each network performance indicator. Thus, in this study the effects of three key factors, i.e. routing protocol, packet size and DSSS rate, were evaluated on key network performance metrics, i.e. average delay and average jitter, as these parameters are crucial for network performance and directly affect the buffering requirements for all video devices and downstream networks.

  13. Analysis of effect of different construction methods of piles on the end effect on skin friction of piles

    ZHOU Hongbo; CHEN Zhuchang

    2007-01-01

    Based on the comparative analysis of end effect on skin friction of displacement-pile (driven pile),the end effect on skin friction of bored pile is studied.The end effect on skin friction between driven pile and bored pile is different and the end effect on skin friction of bored pile is reduce of skin friction in the soil layer adjacent to the pile end.The degradation degree of skin friction is deduced with the increase of the distance from pile end.The concept of additional mud cake formed by the effect of cushion at the bottom of borehole during pouring concrete is introduced to explain the mechanism of end effect on skin friction of the bored pile.The test results of post-grouting piles indicate that the post-grouting technique is an effective way to improve the end effect on skin friction of bored pile.

  14. Research report on a study in MHD power generators - end effects

    Mittal, M.L.

    In MHD devices, there are significant losses due to end effects, boundary layers and instabilities. The present investigations concern the estimation of losses due to end effects. The basic equations and boundary conditions for the analysis of end effects are derived. Using a sinusoidal and exponential termination, at the entrance region of a rectangular MHD channel with continuous electrodes, the end effect phenomenon is analysed. The normal current density on the electrode walls, is examined and the effects of the Hall currents on end losses is discussed. The end effects with diverging electrode walls are also investigated. The normal current distribution on the electrodes and the efficiency are calculated for two different velocity profiles - one with viscosity and the other with source velocity. (K.M.)

  15. Effect of limiter end loss in finite Larmor radius theory

    Berk, H.L.; Kotelnikov, I.A.

    1993-08-01

    We have examined the effect of incomplete line tying on the MHD flute mode with FLR (finite Larmor radius) effects. We show that the combination of line tying and FLR effects can slow down MHD instability, but cannot produce complete stabilization

  16. Effects-Based Operations: The End of Dominant Maneuver?

    Cheek, Gary

    2002-01-01

    .... Many of the recent versions of effects-based operations argue that advances in stealth, precision engagement, and sensor technology have enabled strategic bombing to produce strategic decisions...

  17. The effect of papaine on the time course of the end-plate current.

    Humar, M; Kordas, M; Melik, Z

    1980-07-01

    Papaine is known to detach cholinesterases from the synaptic cleft. It could be expected that this would result in an increase of the amplitude and half-time of the end-plate current. Thus, the effect of papaine on the end-plate current. Thus, the effect of papaine on the end-plate current should be similar to the effect of anticholinesterase methanesulfonylfluoride. The end-plate current was recorded in frog skeletal muscle at various levels of membrane potential, before and after papaine was added to the bath. The effect of papaine was an increase of the half-time of the end-plate current, similarly as after treatment of the muscle by methanesulfonylfluoride. It seems that both papaine and methanesulfonylfluoride have a similar mechanism of action. In either experimental condition hydrolysis of transmitter is decreased or abolished, which results in an increase of the half-time of the end-plate current.

  18. Towards an effective workspace design by end-user emancipation

    Kok, Herman; Mobach, Mark P.; Omta, Onno; Alexander, Keith

    2014-01-01

    Purpose - This paper aims to identify whether employees’ organisational position affect their perceived quality of the workspace design. By providing possible explanations for the differences and discussing the implications, we aim to establish an effective workspace design process that satisfies

  19. The effect of positive end-expiratory pressure on pulse pressure ...

    The effect of positive end-expiratory pressure on pulse pressure variation. FJ Smith, M Geyser, I Schreuder, PJ Becker. Abstract. Objectives: To determine the effect of different levels of positive end-expiratory pressure (PEEP) on pulse pressure variation (PPV). Design: An observational study. Setting: Operating theatres of a ...

  20. End effects in the criticality analysis of burnup credit casks

    Brady, M.C.; Parks, C.V.

    1990-01-01

    A study to evaluate the effect of axially dependent burnup on k eff has been performed as part of an effort to qualify procedures to be used in establishing burnup credit in shipping cask design and certification. This study was performed using a generic 31-element modular cast-iron cask (wall thickness 33.1 cm) with a 1-cm-thick borated stainless-steel basket for reactivity control. Fuel isotopics used here are those of the 17 x 17 Westinghouse assemblies from the North Anna Unit 1 reactor. Virginia Power (VP) provided detailed spatial isotopics for the fuel assemblies in-core at beginning-of-cycle 5 (BOC-5) as generated from their PDQ analyses. Twenty-two axial planes were defined in the original VP data. The isotopics used in this study were for a 3.41 initial wt % 235 U and an average burnup of 31.5 GWd/MTU

  1. Effect of rear end spoiler angle of a sedan car

    Mashud, Mohammad; Das, Rubel Chandra

    2017-06-01

    Automotive vehicle's performance, safety, maneuverability can be influenced by multi-disciplinary factors such as car engine, tires, aerodynamics, and ergonomics of design. With the recent years, inflation in the fuel prices & the demand to have reduced greenhouse emissions has played a significant role in redefining the car aerodynamics. The shape of the vehicle uses about 3% of fuel to overcome the resistance in urban driving, while it takes 11% of fuel for the highway driving. This considerable high value of fuel usage in highway driving attracts several design engineers to enhance the aerodynamics of the vehicle using minimal design changes. Besides, automotive vehicles have become so much faster experiencing uplift force which creates unexpected accidents. This brings the idea of using external devices, which could be attached to the present vehicle without changing the body. This paper is based on the design, developments and numeral calculation of the effects of external device, which will be spoiler that mounted at the rear side of the sedan car to make the present vehicles more aerodynamically attractive. The influence of rear spoiler on the generated lift, drag, and pressure distributions are investigated and reported using commercially available Autodesk Simulation CFD software tool.

  2. Emotional Numbness Modifies the Effect of End-of-Life Discussions on End-of-Life Care

    Maciejewski, Paul K.; Prigerson, Holly G.

    2012-01-01

    Context Overall, end-of-life (EOL) discussions are unrelated to psychological distress and associated with lower rates of aggressive care near death. Nevertheless, patients who report they feel emotionally numb about their illness might encounter difficulties cognitively processing an EOL discussion. Objectives We hypothesized that emotional numbness would modify the influence of EOL discussions on the receipt of less aggressive EOL care. Methods Data were derived from structured interviews with 290 participants in the federally-funded Coping with Cancer Study, a multisite, prospective cohort study of advanced cancer patients followed through their death. Patients’ reports of EOL discussions with their physician and emotional numbness were assessed a median of 4.6 months before death. Information about aggressive EOL care (i.e., ventilation, resuscitation in the last week of life, death in the Intensive Care Unit) was obtained from postmortem caregiver interviews and medical charts. Main and interactive effects of EOL discussions and emotional numbness on aggressive EOL care, adjusting for potential confounds, were evaluated using multiple logistic regression. Results The likelihood of aggressive EOL care associated with having EOL discussions increased by a factor of nine (adjusted odds ratio=9.02, 95% confidence interval 1.37, 59.6, P=0.022) for every unit increase in a patient’s emotional numbness score. Conclusion Emotional numbness diminishes a patient’s capacity to benefit from EOL discussions. EOL decision making may be more effective if clinical communications with emotionally numb patients are avoided. PMID:22926093

  3. The Effects of Normalisation of the Satisfaction of Novice End-User Querying Databases

    Conrad Benedict

    1997-05-01

    Full Text Available This paper reports the results of an experiment that investigated the effects different structural characteristics of relational databases have on information satisfaction of end-users querying databases. The results show that unnormalised tables adversely affect end-user satisfaction. The adverse affect on end-user satisfaction is attributable primarily to the use of non atomic data. In this study, the affect on end user satisfaction of repeating fields was not significant. The study contributes to the further development of theories of individual adjustment to information technology in the workplace by alerting organisations and, in particular, database designers to the ways in which the structural characteristics of relational databases may affect end-user satisfaction. More importantly, the results suggest that database designers need to clearly identify the domains for each item appearing in their databases. These issues are of increasing importance because of the growth in the amount of data available to end-users in relational databases.

  4. End effect braking force reduction in high-speed single-sided linear induction machine

    Shiri, Abbas; Shoulaie, Abbas

    2012-01-01

    Highlights: ► A new analytical equation to model the end effect braking force of SLIM is derived. ► Equations for efficiency, power factor and output thrust are analytically derived. ► The effect of design variables on the performance of the motor is analyzed. ► An optimization method is employed to minimize the end effect braking force (EEBF). ► The results show that EEBF is minimized by appropriate selection of motor parameters. - Abstract: Linear induction motors have been widely employed in industry because of their simple structure and low construction cost. However, they suffer from low efficiency and power factor. In addition, existence of so called end effect influences their performance especially in high speeds. The end effect deteriorates the performance of the motor by producing braking force. So, in this paper, by using Duncan equivalent circuit model, a new analytical equation is proposed to model end effect braking force. Employing the proposed equation and considering all phenomena involved in the single-sided linear induction motor, a simple design procedure is presented and the effect of different design variables on the performance of the motor is analyzed. A multi-objective optimization method based on genetic algorithm is introduced to maximize efficiency and power factor, as well as to minimize the end effect braking force, simultaneously. Finally, to validate the optimization results, 2D finite element method is employed.

  5. Cost effective maintenance to supply end user value: Visionary or utopian

    Wessels, J.; Alten, K.; Turk, M.R.; Palić, S.Š.

    2013-01-01

    Infrastructure stakeholders expect maintenance managers to deliver acceptable End User Service Levels (EUSL), such as availability, comfort, and safety. Means of controlling these requirements involve technical maintenance and operative measures. Within the ERANET Road Program 'Effective asset

  6. End effect Keff bias curve for actinide-only burnup credit casks

    Kang, C.H.; Lancaster, D.B.

    1997-01-01

    A conservative end effect k eff bias curve for actinide-only burnup credit for spent fuel casks is presented in this paper. The k eff bias values can be added to the uniform axial burnup analysis to conservatively bound the actinide-only end effect. A normalized axial burnup distribution for the standard Westinghouse 17 x 17 assembly design is used for calculating k eff . The end effect calculated is a strong function of burnup, and increases as cask size size decreases. The presence of poison plates increases the end effect. The bias curve presented is based on the most limiting cask configuration of a single PWR assembly with completely black poison plates. Therefore, axially uniform criticality calculations with application of the proposed k eff could eliminate the need for axially burnup dependent analyses. 7 refs., 1 fig

  7. Effects of a Simulation Exercise on Nursing Students' End-of-Life Care Attitudes.

    Dame, Linda; Hoebeke, Roberta

    2016-12-01

    Students consider end-of-life care content in their nursing curricula to be inadequate and deficient in promoting the development of the necessary attitudes to care for dying patients. Research identifies simulation as an effective teaching strategy to examine nursing students' attitudes toward end-of-life care. An end-of-life care simulation was developed, implemented, and evaluated. Attitudes toward caring for dying patients were measured pre- and postsimulation on a convenience sample of 57 sophomore nursing students using the Frommelt Attitudes Toward Care of the Dying Scale-Form B. Repeated measures of ANOVA on outcome variables evaluated student attitudes toward end-of-life care. Participation in an end-of-life care simulation resulted in more positive student attitudes toward caring for dying patients (p life care in nursing curricula and improve student attitudes toward caring for dying patients. [J Nurs Educ. 2016;55(12):701-705.]. Copyright 2016, SLACK Incorporated.

  8. Effect of end reflections on conversion efficiency of coaxial relativistic backward wave oscillator

    Teng, Yan; Chen, Changhua; Sun, Jun; Shi, Yanchao; Ye, Hu; Wu, Ping; Li, Shuang; Xiong, Xiaolong [Science and Technology on High Power Microwave Laboratory, Northwest Institute of Nuclear Technology, Xi' an 710024 (China)

    2015-11-07

    This paper theoretically investigates the effect of end reflections on the operation of the coaxial relativistic backward wave oscillator (CRBWO). It is found that the considerable enhancement of the end reflection at one end increases the conversion efficiency, but excessively large end reflections at both ends weaken the asynchronous wave-beam interaction and thus reduce the conversion efficiency. Perfect reflection at the post end significantly improves the interaction between the electron beam and the asynchronous harmonic so that the conversion efficiency is notably increased. Based on the theoretical research, the diffraction-CRBWO with the generated microwave diffracted and output through the front end of the coaxial slow wave structure cavity is proposed. The post end is conductively closed to provide the perfect reflection. This promotes the amplitude and uniformity of the longitudinal electric field on the beam transmission line and improves the asynchronous wave-beam interaction. In numerical simulations under the diode voltage and current of 450 kV and 5.84 kA, microwave generation with the power of 1.45 GW and the conversion efficiency of 55% are obtained at the frequency of 7.45 GHz.

  9. The continuous end-state comfort effect: weighted integration of multiple biases.

    Herbort, Oliver; Butz, Martin V

    2012-05-01

    The grasp orientation when grasping an object is frequently aligned in anticipation of the intended rotation of the object (end-state comfort effect). We analyzed grasp orientation selection in a continuous task to determine the mechanisms underlying the end-state comfort effect. Participants had to grasp a box by a circular handle-which allowed for arbitrary grasp orientations-and then had to rotate the box by various angles. Experiments 1 and 2 revealed both that the rotation's direction considerably determined grasp orientations and that end-postures varied considerably. Experiments 3 and 4 further showed that visual stimuli and initial arm postures biased grasp orientations if the intended rotation could be easily achieved. The data show that end-state comfort but also other factors determine grasp orientation selection. A simple mechanism that integrates multiple weighted biases can account for the data.

  10. Influence of timer end-effects on Gamma knife (Type B) treatment

    Baba, Sadaaki; Ito, Teruo; Toyoda, Tatsuya; Wakamatsu, Osamu; Machida, Toru

    2004-01-01

    We investigated the influence of timer end-effects retrospectively in cases treated with Gamma knife (Type B) in the first year and in the fifth year after installation. Objects were 113 cases from April 1997 to December 1997 and 230 cases between January 2001 and December 2001. The influence of timer end-effects was calculated in the following formula: influence of timer end-effects=Σ (timer end-effects/shot time)/(number of lesions x number of shots). Ten factors such as the output at the center of polystyrene sphere phantom, the number of lesions, the number of shots, the delivered maximum absorbed dose, total irradiation time and the frequency in the use of each collimator helmet were examined as factors of the influence. The average values of timer end-effects were 4.7±0.27, 4.3±0.27, 3.6±0.24 and 3.5±0.29%/min. for 18, 14, 8 and 4 mm collimator helmets, respectively and depended on field size. We believe that the unit '%/min.' must be accepted instead of '%'. Gamma knife treatment is stereotactic radiosurgery and 40-50 Gy is irradiated within several hours with about ten shots. So the influence of timer end-effects was calculated 0.82±0.80% in 1997 and 0.51±0.41% in 2001 on average. These data suggest that there was little influence on the treatment. These figures were average values per lesion, so the influence may be more complicated in each part of lesions. The difference between the influence of timer end-effects in 1997 and 2001 was considered to be caused by the elongation of shot time according to Cobalt-60 decay, the reduction of the number of shots by frequent use of 14 mm collimator helmet, and the restriction of the number of treated lesions. (author)

  11. Experimental research on end-to-side anastomosis of peripheral nerves and effect of FK506 on end-to-side anastomosis.

    Yang, L M; Wu, Y X; Zhang, X P; Li, X H

    2014-01-01

    To study the effects of end-to-side anastomosis of initially-denatured nerves at different times. 60 male Wistar albino rats were used to fabricate animal models for the experiment on end-to-side anastomosis of peripheral nerves and 50 female Wistar albino rats were used to fabricate animal models for the experiment on the effect of FK506 on end-to-side anastomosis. Bilateral common peroneal nerve, tibialis anterior muscle electrophysiological and histological examinations, tibialis anterior muscle wet muscle weight determination, and motor end plate examination were performed 3 months after operation. All recovery rates of action potential, single muscle contraction force and tetanic contraction force of the FK506 experimental group are significantly higher than those of the control group and the sectional area of muscle fiber is also higher than that of the control group of normal saline. The best time for end-to-side anastomosis of nerves should be controlled within 2 weeks and the effect of end-to-side anastomosis of nerves will gradually become unsatisfactory. FK506 plays a role in promoting functional rehabilitation following nerve end-to-side anastomosis (Tab. 7, Fig. 4, Ref. 31).

  12. Oncologists' strategies and barriers to effective communication about the end of life.

    Granek, Leeat; Krzyzanowska, Monika K; Tozer, Richard; Mazzotta, Paolo

    2013-07-01

    Communicating about the end of life with patients has been reported as one of the most difficult and stressful part of the work of oncologists. Despite this fact, oncologists receive little training in this area, and many do not communicate effectively with patients. The purpose of this analysis, part of a larger study examining oncologists' experiences of patient loss, was to explore oncologists' communication strategies and communication barriers when discussing end-of-life issues with patients. Twenty oncologists were interviewed at three hospitals about their communication strategies on end-of-life issues with patients. The data were analyzed using the grounded theory method. The findings revealed the strategies to effective communication about the end of life included: being open and honest; having ongoing, early conversations; communicating about modifying treatment goals; and balancing hope and reality. Barriers to implementing these strategies fell broadly into three domains, including physician factors, patient factors, and institutional factors. Physician factors included difficulty with treatment and palliation, personal discomfort with death and dying, diffusion of responsibility among colleagues, using the "death-defying mode," lack of experience, and lack of mentorship. Patient factors included, patients and/or families being reluctant to talk about the end of life, language barriers, and younger age. Institutional factors included stigma around palliative care, lack of protocol about end-of-life issues; and lack of training for oncologists on how to talk with patients about end-of-life issues. We conclude by drawing implications from our study and suggest that further research and intervention are necessary to aid oncologists in achieving effective communication about end-of-life issues.

  13. End to End Travel

    US Agency for International Development — E2 Solutions is a web based end-to-end travel management tool that includes paperless travel authorization and voucher document submissions, document approval...

  14. Short-term effects of dietary advanced glycation end products in rats

    Poulsen, Malene Wibe; Andersen, Jeanette Marker; Hedegaard, Rikke Susanne Vingborg

    2016-01-01

    Dietary advanced glycation end products (AGE) formed during heating of food have gained interest as potential nutritional toxins with adverse effects on inflammation and glucose metabolism. In the present study, we investigated the short-term effects of high and low molecular weight (HMW and LMW)...

  15. Effect of folic acid on methionine and homocysteine metabolism in end-stage renal disease

    Stam, F.; van Guldener, C.; ter Wee, P.M.; Jakobs, C.A.J.M.; van der Meer, K.; Stehouwer, C.D.A.

    2005-01-01

    Background. The pathogenesis of hyperhomocysteinemia in end-stage renal disease (ESRD) is unclear. Folic acid lowers, but does not normalize, the plasma homocysteine level in patients with ESRD, but its effect on whole body metabolism of homocysteine is unknown. Methods We studied the effect of 3

  16. Electrical breakthrough effect for end pointing in 90 and 45 nm node circuit edit

    Liu, Kun; Soskov, Alex; Scipioni, Larry; Bassom, Neil; Sijbrandij, Sybren; Smith, Gerald

    2006-01-01

    The interaction between high-energy Ga + ions and condensed matter is studied for circuit edit applications. A new 'electrical breakthrough effect' due to charging of, and Ga + penetration/doping into, dielectrics is discovered. This new effect is proposed for end pointing in 90 and 45 nm node circuit edits where integrated circuit device dimensions are of a few hundred nanometers. This new end point approach is very sensitive, reliable, and precise. Most importantly, it is not sensitive to device dimensions. A series of circuit edits involving milling holes of high aspect ratio (5-30) and small cross-section area (0.01-0.25 μm 2 ) on real chips has been successfully performed using the electrical breakthrough effect as the end point method

  17. MUON POLARIZATION EFFECTS IN THE FRONT END OF THE NEUTRINO FACTORY

    FERNOW, R.C.; GALLARDO, J.C.; FUKUI, Y.

    2000-01-01

    The authors summarize the methods used for simulation of polarization effects in the front end of a possible neutrino factory. They first discuss the helicity of muons in the pion decay process. They find that, neglecting acceptance considerations, the average helicity asymptotically approaches a magnitude of 0.185 at large pion momenta. Next they describe the methods used for tracking the spin through the complicated electromagnetic field configurations in the front end of the neutrino factory, including rf phase rotation and ionization cooling channels. Various depolarizing effects in matter are then considered, including multiple Coulomb scattering and elastic scattering from atomic electrons. Finally, they include all these effects in a simulation of a 480 m long, double phase rotation front end scenario

  18. The medical effects of radioactive fall-out: role of stable end-products

    Burrows, B.A.; Cardarelli, J.C.; Boling, E.A.; Sinex, F.M.

    1980-01-01

    To summarize, from preliminary observations on the possible effects of radioactive fall-out, it may be inferred that in addition to the secondary products of ionizing irradiation per se, the stable end-products of the transmutation of certain radionuclides may adversely influence cellular metabolism, including mutagenesis. The discussion of the possible role of intracellular barium as an end-product of 137Cs decay is offered as an example of an unpredictable number of broad ecological, as well as the more limited medical, effects that may be of both clinical and climatological significance

  19. Mutagenic effects of carbon ions near the range end in plants

    Hase, Yoshihiro, E-mail: hase.yoshihiro@jaea.go.jp [Ion Beam Mutagenesis Research Group, Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki, Takasaki, Gunma 370-1292 (Japan); Yoshihara, Ryouhei; Nozawa, Shigeki; Narumi, Issay [Ion Beam Mutagenesis Research Group, Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki, Takasaki, Gunma 370-1292 (Japan)

    2012-03-01

    To gain insight into the mutagenic effects of accelerated heavy ions in plants, the mutagenic effects of carbon ions near the range end (mean linear energy transfer (LET): 425 keV/{mu}m) were compared with the effects of carbon ions penetrating the seeds (mean LET: 113 keV/{mu}m). Mutational analysis by plasmid rescue of Escherichia coli rpsL from irradiated Arabidopsis plants showed a 2.7-fold increase in mutant frequency for 113 keV/{mu}m carbon ions, whereas no enhancement of mutant frequency was observed for carbon ions near the range end. This suggested that carbon ions near the range end induced mutations that were not recovered by plasmid rescue. An Arabidopsis DNA ligase IV mutant, deficient in non-homologous end-joining repair, showed hyper-sensitivity to both types of carbon-ion irradiation. The difference in radiation sensitivity between the wild type and the repair-deficient mutant was greatly diminished for carbon ions near the range end, suggesting that these ions induce irreparable DNA damage. Mutational analysis of the Arabidopsis GL1 locus showed that while the frequency of generation of glabrous mutant sectors was not different between the two types of carbon-ion irradiation, large deletions (>{approx}30 kb) were six times more frequently induced by carbon ions near the range end. When 352 keV/{mu}m neon ions were used, these showed a 6.4 times increase in the frequency of induced large deletions compared with the 113 keV/{mu}m carbon ions. We suggest that the proportion of large deletions increases with LET in plants, as has been reported for mammalian cells. The nature of mutations induced in plants by carbon ions near the range end is discussed in relation to mutation detection by plasmid rescue and transmissibility to progeny.

  20. Innovative strategy for effective critical laboratory result management: end-to-end process using automation and manual call centre.

    Ti, Lian Kah; Ang, Sophia Bee Leng; Saw, Sharon; Sethi, Sunil Kumar; Yip, James W L

    2012-08-01

    Timely reporting and acknowledgement are crucial steps in critical laboratory results (CLR) management. The authors previously showed that an automated pathway incorporating short messaging system (SMS) texts, auto-escalation, and manual telephone back-up improved the rate and speed of physician acknowledgement compared with manual telephone calling alone. This study investigated if it also improved the rate and speed of physician intervention to CLR and whether utilising the manual back-up affected intervention rates. Data from seven audits between November 2007 and January 2011 were analysed. These audits were carried out to assess the robustness of CLR reporting process in the authors' institution. Comparisons were made in the rate and speed of acknowledgement and intervention between the audits performed before and after automation. Using the automation audits, the authors compared intervention data between communication with SMS only and when manual intervention was required. 1680 CLR were reported during the audit periods. Automation improved the rate (100% vs 84.2%; pautomation audits, the use of SMS only did not improve physician intervention rates. The automated communication pathway improved physician intervention rate and time in tandem with improved acknowledgement rate and time when compared with manual telephone calling. The use of manual intervention to augment automation did not adversely affect physician intervention rate, implying that an end-to-end pathway was more important than automation alone.

  1. One dimensional analysis of the end effect of an EM pump

    Kim, Hee Reyoung; Nam, Ho Yun; Kim, Yong Kyun; Choi, Byoung Hae; Lee, Yong Bum; Kim, Min Joon; Hong, Sang Hee

    1998-01-01

    Longitudinal end effect due to finite length of the pump are analyzed one dimensionally on an annular linear induction electromagnetic (EM) pump for the transportation of the electrically conducting liquid metal. The mathematical regions of the modeled pump is divided into three of the inlet, outlet and developing zone in large parts. Solving governing equations with the applied boundary condition, the distributions of magnetic field and developing force are investigated according to the coordinate of axial direction and compared with those of the pump with infinite length. At both ends of the pump, it is shown that the radial magnetic field is distorted and even the opposite force, which may cause local separation of the flow as the velocity of the pumping fluid is increased, is generated at the inlet region. In the present study, frequency control is suggested as one of the methods for the reduction of the end effect of the pump

  2. Economic and Water Supply Effects of Ending Groundwater Overdraft in California's Central Valley

    Timothy Nelson

    2016-03-01

    Full Text Available doi: http://dx.doi.org/10.15447/sfews.2016v14iss1art7Surface water and groundwater management are often tightly linked, even when linkage is not intended or expected. This link is especially common in semi-arid regions, such as California. This paper summarizes a modeling study on the effects of ending long-term overdraft in California’s Central Valley, the state’s largest aquifer system. The study focuses on economic and operational aspects, such as surface water pumping and diversions, groundwater recharge, water scarcity, and the associated operating and water scarcity costs. This analysis uses CALVIN, a hydro-economic optimization model for California’s water resource system that suggests operational changes to minimize net system costs for a given set of conditions, such as ending long-term overdraft. Based on model results, ending overdraft might induce some major statewide operational changes, including large increases to Delta exports, more intensive conjunctive-use operations with increasing artificial and in-lieu recharge, and greater water scarcity for Central Valley agriculture. The statewide costs of ending roughly 1.2 maf yr-1 of groundwater overdraft are at least $50 million per year from additional direct water shortage and additional operating costs. At its worst, the costs of ending Central Valley overdraft could be much higher, perhaps comparable to the recent economic effects of drought. Driven by recent state legislation to improve groundwater sustainability, ending groundwater overdraft has important implications statewide for water use and management, particularly in the Sacramento–San Joaquin Delta. Ending Central Valley overdraft will amplify economic pressure to increase Delta water exports rather than reduce them, tying together two of California’s largest water management problems.

  3. Contribution games and the end-game effect: When things get real - An experimental analysis

    Bar-El, Ronen; Tobol, Yossi

    2013-01-01

    We conduct a contribution game for a real public good and show that when the contributors value the real public good highly, they increase their contributions in each round. Thus, contrary to previous literature, free riding decreases over rounds and the end-game effect is reversed.

  4. Soft modes at the critical end point in the chiral effective models

    Fujii, Hirotsugu; Ohtani, Munehisa

    2004-01-01

    At the critical end point in QCD phase diagram, the scalar, vector and entropy susceptibilities are known to diverge. The dynamic origin of this divergence is identified within the chiral effective models as softening of a hydrodynamic mode of the particle-hole-type motion, which is a consequence of the conservation law of the baryon number and the energy. (author)

  5. Is Chronic Dialysis the Right Hard Renal End Point To Evaluate Renoprotective Drug Effects?

    Weldegiorgis, Misghina; de Zeeuw, Dick; Dwyer, Jamie P.; Mol, Peter; Heerspink, Hiddo J. L.

    2017-01-01

    Background and objectives: RRT and doubling of serum creatinine are considered the objective hard end points in nephrology intervention trials. Because both are assumed to reflect changes in the filtration capacity of the kidney, drug effects, if present, are attributed to kidney protection.

  6. Debris filtering effectiveness and pressure drop tests of debris resistance-bottom end piece

    Chung, Moon Ki; Song, Chul Hwa; Chung, Heung June; Won, Soon Yeun; Cho, Young Ro; Kim, Bok Deuk

    1992-03-01

    In this final report, described are the test conditions and test procedures for the debris filtering effectiveness and pressure drop tests for developing the Debris Resistance-Bottom End Piece (DR-BEP). And the test results are tabulated for later evaluation. (Author)

  7. End Effects in Rotational Viscometry II. Pseudoplastic Fluids at Elevated Reynolds Number.

    Wein, Ondřej; Pěnkavová, Věra; Havlica, Jaromír

    2015-01-01

    Roč. 54, č. 11 (2015), s. 903-914 ISSN 0035-4511 R&D Projects: GA ČR(CZ) GAP105/12/0664 Institutional support: RVO:67985858 Keywords : rotational couette viscometry * pseudoplastic fluids * end effects Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 2.184, year: 2015

  8. Effects of renal denervation on end organ damage in hypertensive patients

    Verloop, WL; Vink, Eva E.; Spiering, Wilko; Blankestijn, PJ; Doevendans, Pieter A.; Bots, Michiel L.; Vonken, EPA; Voskuil, Michiel; Leiner, Tim

    Background: Renal denervation (RDN) is believed to reduce sympathetic nerve activity and is a potential treatment for resistant hypertension. The present study investigated the effects of RDN on end organ damage (EOD). Design: The present study was a prospective cohort study (registered as

  9. Influences of viscous losses and end effects on liquid metal flow in electromagnetic pumps

    Kim, Hee Reyoung; Seo, Joon Ho; Hong, Sang Hee; Cho, Su won; Nam, Ho Yun; Cho, Man

    1996-01-01

    Analyses of the viscous and end effects on electromagnetic (EM) pumps of annular linear induction type for the sodium coolant circulation in Liquid Metal Fast Breeder Reactors have been carried out based on the MHD laminar flow analysis and the electromagnetic field theory. A one-dimensional MHD analysis for the liquid metal flowing through an annular channel has been performed on the basis of a simplified model of equivalent current sheets instead of three-phase currents in the discrete primary windings. The calculations show that the developed pressure difference resulted from electromagnetic and viscous forces in the liquid metal is expressed in terms of the slip, and that the viscous loss effects are negligible compared with electromagnetic driving forces except in the low-slip region where the pumps operate with very high flow velocities comparable with the synchronous velocity of the electromagnetic fields, which is not applicable to the practical EM pumps. A two-dimensional electromagnetic field analysis based on an equivalent current sheet model has found the vector potentials in closed form by means of the Fourier transform method. The resultant magnetic fields and driving forces exerted on the liquid metal reveal that the end effects due to finiteness of the pump length are formidable. In addition, a two-dimensional numerical analysis for vector potentials has been performed by the SOR iterative method on a realistic EM pump model with discretely-distributed currents in the primary windings. The numerical computations for the distributions of magnetic fields and developed pressure differences along the pump axial length also show considerable end effects at both inlet and outlet ends, especially at high flow velocities. Calculations of each magnetic force contribution indicate that the end effects are originated from the magnetic force caused by the induced current (υxB) generated by the liquid metal movement across the magnetic field rather than the one

  10. Effects of the partially movable control fin with end plate of underwater vehicle

    Chul-Min Jung

    2017-01-01

    Full Text Available Underwater torpedo has control fin with very low aspect ratio due to launching from limited size of cylindrical torpedo tube. If the aspect ratio of control fin of underwater vehicle is very low three-dimensional flow around control fin largely reduces control forces. In this study, the end plate was applied to reduce the three-dimensional flow effects of partially movable control fin of underwater vehicle. Through numerical simulations the flow field around control fin was examined with and without end plate for different flap angles. The pressure, vorticity, lift and torque on the control fin were analyzed and compared to experiments. The comparison have shown a reasonable agreement between numerical and experimental results and the effect of end plate on a low aspect ratio control fin. When the end plate was attached to the movable control fin, the lift increased and the actuator shaft torque did not significantly change. As this means less consumption of the actuator shaft torque compared to the control fin that has the same control force, the inner actuator capacity can be reduced and energy consumption can be saved. Considering this, it is expected to be effectively applied to the control fin design of underwater vehicles such as torpedoes.

  11. Effect of two storage solutions on surface topography of two root-end fillings.

    Asgary, Saeed; Eghbal, Mohammad Jafar; Parirokh, Masoud; Ghoddusi, Jamileh

    2009-12-01

    The effect of different storage solutions on surface topography of mineral trioxide aggregate (MTA) and new experimental cement (NEC) as root-end fillings was investigated. Twenty-four single-rooted teeth were cleaned, shaped and obturated in a same manner. After root-end resection, 3-mm deep root-end cavities were ultrasonically prepared. Samples were randomly divided into four test groups (A1-A2-B1-B2, n = 6). Root-end cavities in groups A and B were filled with MTA and NEC, respectively, and were then stored in 100% humidity for 24 h. The samples of groups 1 and 2 were, respectively, immersed in normal saline (NS) and phosphate buffer saline solutions for 1 week. The samples were imaged under stereomicroscope before and after immersion and were then investigated and analysed by scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDXA). Results showed significant difference among studied groups. Surface topography of all samples was altered by crystal formation and precipitation on root-end fillings except for group A1 (MTA-NS). SEM and EDXA results showed that the composition and structure of precipitated crystals were comparable with that of standard hydroxyapatite. It was concluded that biocompatibility, sealing ability, and cementogenic activity of MTA and probably NEC may be attributed to this fundamental bioactive reaction.

  12. The Analysis of an End Effect according to the Input Frequency Change in the EM Pump

    Kim, Hee Reyoung; Kim, Jong Man; Cha, Jae Eun; Choi, Jong Hyun; Nam, Ho Yoon

    2006-01-01

    In general, an electromagnetic (EM) pump is considered to circulate a liquid sodium coolant for a Sodium Fast Reactor (SFR). The EM pump has an end effect at both ends basically due to its finite core length. The generated magnetic field across the flow gap is distorted at both ends of the pump. Consequently, there arises reduction on the developed force by the vector product of that magnetic field and its perpendicular induced current. Especially, it experiences even the opposite pumping force near the pump inlet. That causes low efficiency of the pump and resultantly brings about bad performance of a pump. The present study theoretically shows that this end effect can be lessened by control of input frequency. It is predicted that pump operates much more efficiently in the range of low frequency around teen hertz than in that of high frequency over 60 Hz. The force density is investigated in the narrow annular channel of the pump with the length of 84cm according to pump axial coordinates at various frequency

  13. Selecting Effective Means to Any End: Futures and Ethics of Persuasion Profiling

    Kaptein, Maurits; Eckles, Dean

    Interactive persuasive technologies can and do adapt to individuals. Existing systems identify and adapt to user preferences within a specific domain: e.g., a music recommender system adapts its recommended songs to user preferences. This paper is concerned with adaptive persuasive systems that adapt to individual differences in the effectiveness of particular means, rather than selecting different ends. We give special attention to systems that implement persuasion profiling - adapting to individual differences in the effects of influence strategies. We argue that these systems are worth separate consideration and raise unique ethical issues for two reasons: (1) their end-independence implies that systems trained in one context can be used in other, unexpected contexts and (2) they do not rely on - and are generally disadvantaged by - disclosing that they are adapting to individual differences. We use examples of these systems to illustrate some ethically and practically challenging futures that these characteristics make possible.

  14. No significant effect of angiotensin II receptor blockade on intermediate cardiovascular end points in hemodialysis patients

    Peters, Christian Daugaard; Kjaergaard, Krista D; Jensen, Jens D

    2014-01-01

    Agents blocking the renin-angiotensin-aldosterone system are frequently used in patients with end-stage renal disease, but whether they exert beneficial cardiovascular effects is unclear. Here the long-term effects of the angiotensin II receptor blocker, irbesartan, were studied in hemodialysis......, and residual renal function. Brachial blood pressure decreased significantly in both groups, but there was no significant difference between placebo and irbesartan. Use of additional antihypertensive medication, ultrafiltration volume, and dialysis dosage were not different. Intermediate cardiovascular end...... points such as central aortic blood pressure, carotid-femoral pulse wave velocity, left ventricular mass index, N-terminal brain natriuretic prohormone, heart rate variability, and plasma catecholamines were not significantly affected by irbesartan treatment. Changes in systolic blood pressure during...

  15. Effects of positive end-expiratory pressure on arthroscopic shoulder surgery under general anesthesia.

    Ersoy, Ayşın; Çakırgöz, Mensure; Ervatan, Zekeriya; Kıran, Özlem; Türkmen, Aygen; Esenyel, Cem Zeki

    2016-01-01

    Our study is a prospective, randomized study on patients undergoing arthroscopic shoulder surgery in the beach-chair position to evaluate the effects of positive end-expiratory pressure (PEEP) on hemodynamic stability, providing a bloodless surgical field and surgical satisfaction. Fifty patients were divided into two groups. Group I (n=25) had zero end-expiratory pressure (ZEEP) administered under general anesthesia, and group II (n=25) had +5 PEEP administered. During surgery, intraarticular hemorrhage and surgical satisfaction were evaluated on a scale of 0-10. During surgery, at the 5th, 30th, 60th, and 90th minutes and at the end of surgery, heart rate, mean arterial pressure (MAP), and positive inspiratory pressure were recorded. At the end of the surgery, the amount of bleeding and duration of the operation were recorded. In group I, the duration of operation and amount of bleeding were found to be significantly greater than those in group II (pshoulder surgery in the beach-chair position reduces the amount of hemorrhage in the surgical field and thus increases surgical satisfaction without requiring the creation of controlled hypotension.

  16. Transmission of vocational skills at the end of career: horizon effect and technological or organisational change

    Greenan , Nathalie; Messe , Pierre-Jean

    2014-01-01

    The main contribution of this paper is to study empirically how the horizon effect and the technological or organisational changes interact to explain the probability of being an internal trainer at the end of career. We use data from a French matched employer-employee survey on Organisational Changes and Computerisation (COI) conducted in 2006. It contains information both on employees’ knowledge transmission practices and employers’ technological or organisational changes. We find that the ...

  17. Investigation on Effect of Material Hardness in High Speed CNC End Milling Process

    Dhandapani, N. V.; Thangarasu, V. S.; Sureshkannan, G.

    2015-01-01

    This research paper analyzes the effects of material properties on surface roughness, material removal rate, and tool wear on high speed CNC end milling process with various ferrous and nonferrous materials. The challenge of material specific decision on the process parameters of spindle speed, feed rate, depth of cut, coolant flow rate, cutting tool material, and type of coating for the cutting tool for required quality and quantity of production is addressed. Generally, decision made by the...

  18. Australian guidelines for cost-effectiveness studies of pharmaceuticals: the thin end of the boomerang?

    Mike Drummond

    1991-01-01

    In the summer of 1990, the Australian government took a major step by requiring evidence of cost-effectiveness of new medicines prior to reimbursement by the public health care system. This paper assesses whether the methodological principles behind the guidelines are sound and whether they raise important new logistical and policy implications. It is concluded that, whilst the guidelines may represent ‘the thin end of the wedge’ for the pharmaceutical industry, in that other countries may fo...

  19. Systematics of multi-field effects at the end of warped brane inflation

    Chen, Heng-Yu; Shiu, Gary

    2008-01-01

    We investigate in the context of brane inflation the possibility of additional light scalar fields generating significant power spectrum and non-Gaussianities at the end of inflation affecting the CMB scale observations. We consider the specific mechanism outlined by Lyth and describe the necessary criteria for it to be potentially important in a warped throat. We also discuss different mechanisms for uplifting the vacuum energy which can lead to different dominant contributions of the inflaton potential near the end of inflation. We then apply such criteria to one of the most detailed brane inflation models to date, and show that inflation can persist towards the tip of the throat, however for the specific stable inflationary trajectory, the light residual isometry direction becomes degenerate. We also estimate the effects for other inflationary trajectories with non-degenerate residual isometries.

  20. Investigation of the effect of cutting speed on the Surface Roughness parameters in CNC End Milling using Artificial Neural Network

    Al Hazza, Muataz H F; Adesta, Erry Y T

    2013-01-01

    This research presents the effect of high cutting speed on the surface roughness in the end milling process by using the Artificial Neural Network (ANN). An experimental investigation was conducted to measure the surface roughness for end milling. A set of sparse experimental data for finish end milling on AISI H13 at hardness of 48 HRC have been conducted. The artificial neural network (ANN) was applied to simulate and study the effect of high cutting speed on the surface roughness

  1. Merchandising at the point of sale: differential effect of end of aisle and islands

    Álvaro Garrido-Morgado

    2015-01-01

    Full Text Available Merchandising at point of sale comprises a set of techniques aimed at encouraging the purchase at the point of sale. This paper analyzes the impact on sales of two of these techniques, especially used in the context of non-specialized food stores and rarely distinguished in academic research: (1 the presentation of product in the ends of the aisles or main aisles, leading from the side aisle access and, (2 the presentation of the product in islands within the main aisles. This research combines cross-sectional and longitudinal data and analyzes specific information on sales and commercial stimulus for all references in two large categories of products from a hypermarket over ten weeks. Results show that both the ends of aisle and the islands have a positive effect on sales and their relative importance depends on the nature of the category analyzed. There are also greater synergies between ends of aisle and price promotions. Finally, the results provide some evidence into the impact of the extension or termination of these merchandising stimuli.

  2. Effects of ginger on serum glucose, advanced glycation end products, and inflammation in peritoneal dialysis patients.

    Imani, Hossein; Tabibi, Hadi; Najafi, Iraj; Atabak, Shahnaz; Hedayati, Mehdi; Rahmani, Leila

    2015-05-01

    The aim of this study was to investigate the effects of ginger supplementation on serum glucose, advanced glycation end products, oxidative stress, and systemic and vascular inflammatory markers in patients on peritoneal dialysis (PD). In this randomized, double-blind, placebo-controlled trial, 36 patients on PD were randomly assigned to either the ginger or the placebo group. The patients in the ginger group received 1000 mg/d ginger for 10 wk, whereas the placebo group received corresponding placebos. At baseline and the end of week 10, serum concentrations of glucose, carboxymethyl lysine, pentosidine, malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), soluble intercellular adhesion molecule type 1 (sICAM-1), soluble vascular cell adhesion molecule type 1 (sVCAM-1), and sE-selectin were measured after a 12- to 14-h fast. Serum fasting glucose decreased significantly up to 20% in the ginger group at the end of week 10 compared with baseline (P ginger reduces serum fasting glucose, which is a risk factor for hyperinsulinemia, dyslipidemia, peritoneal membrane fibrosis, and cardiovascular disease, in patients on PD. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Ventilatory effects of hypercapnic end-tidal PCO2 clamps during aerobic exercise of varying intensity.

    Essfeld, D; Hoffmann, U; Stegemann, J

    1990-01-01

    Nine subjects performed a sequence of sustained and randomised changes between 40 W and 100 W on a cycle ergometer while the end-tidal PO2 was kept close to 17.3 kPa (130 mm Hg) by means of a dynamic forcing technique (reference experiment). In a second series inspiratory CO2 was additionally manipulated so as to hold end-tidal PCO2 (PETCO2) near 6.5 kPa (49 mm Hg; 'CO2-clamp' experiment). By this forcing PETCO2 oscillations were attenuated and more evenly distributed over the frequency range. Ventilation (VT) responded to this manoeuvre with an upward trend that could not be ascribed to a slow CO2-response component, changes in metabolic rate or a dissociation of end-tidal and arterial PCO2. VT differences between reference and CO2-clamp experiments were abolished within a 3-min period following the termination of the external CO2 control. The present results suggest that the CO2-H+ stimulus plays a major role in adjusting ventilation when exercise intensity is decreased. The underlying CO2 effect appears to be neither additive nor bi-directionally symmetrical.

  4. Effects of photobleaching on selected advanced glycation end products in the human lens

    Holm, Thomas; Raghavan, Cibin T; Nahomi, Rooban

    2015-01-01

    at examining the optical and biochemical effects of the proposed treatment.MethodsHuman donor lenses were photobleaced using a 445 nm cw laser. Lens optical quality was assessed before and after photobleaching by light transmission and scattering. The concentration of the advanced glycation end products (AGEs...... of the photobleaching treatment on lens optical parameters but we could not associate the optical findings to a change in the concentration of the AGEs we measured. This finding suggests that other AGEs were responsible for the observed photobleaching of the human lens after laser treatment. The biochemical nature...

  5. Lack of Bystander Effects From High-LET Radiation For Early Cytogenetic End Points

    Groesser, Torsten; Cooper, Brian; Rydberg, Bjorn

    2008-01-01

    The aim of this work was to study radiation-induced bystander effects for early cytogenetic end points in various cell lines using the medium transfer technique after exposure to high- and low-LET radiation. Cells were exposed to 20 MeV/ nucleon nitrogen ions, 968 MeV/nucleon iron ions, or 575 MeV/nucleon iron ions followed by transfer of the conditioned medium from the irradiated cells to unirradiated test cells. The effects studied included DNA double-strand break induction, γ-H2AX focus formation, induction of chromatid breaks in prematurely condensed chromosomes, and micronucleus formation using DNA repair-proficient and -deficient hamster and human cell lines (xrs6, V79, SW48, MO59K and MO59J). Cell survival was also measured in SW48 bystander cells using X rays. Although it was occasionally possible to detect an increase in chromatid break levels using nitrogen ions and to see a higher number of γ-H2AX foci using nitrogen and iron ions in xrs6 bystander cells in single experiments, the results were not reproducible. After we pooled all the data, we could not verify a significant bystander effect for any of these end points. Also, we did not detect a significant bystander effect for DSB induction or micronucleus formation in these cell lines or for clonogenic survival in SW48 cells. The data suggest that DNA damage and cytogenetic changes are not induced in bystander cells. In contrast, data in the literature show pronounced bystander effects in a variety of cell lines, including clonogenic survival in SW48 cells and induction of chromatid breaks and micronuclei in hamster cells. To reconcile these conflicting data, it is possible that the epigenetic status of the specific cell line or the precise culture conditions and medium supplements, such as serum, may be critical for inducing bystander effects.

  6. Single event effect hardness for the front-end ASICs in the DAMPE satellite BGO calorimeter

    Gao, Shan-Shan; Jiang, Di; Feng, Chang-Qing; Xi, Kai; Liu, Shu-Bin; An, Qi

    2016-01-01

    The Dark Matter Particle Explorer (DAMPE) is a Chinese scientific satellite designed for cosmic ray studies with a primary scientific goal of indirect detection of dark matter particles. As a crucial sub-detector, the BGO calorimeter measures the energy spectrum of cosmic rays in the energy range from 5 GeV to 10 TeV. In order to implement high-density front-end electronics (FEE) with the ability to measure 1848 signals from 616 photomultiplier tubes on the strictly constrained satellite platform, two kinds of 32-channel front-end ASICs, VA160 and VATA160, are customized. However, a space mission period of more than 3 years makes single event effects (SEEs) become threats to reliability. In order to evaluate SEE sensitivities of these chips and verify the effectiveness of mitigation methods, a series of laser-induced and heavy ion-induced SEE tests were performed. Benefiting from the single event latch-up (SEL) protection circuit for power supply, the triple module redundancy (TMR) technology for the configuration registers and the optimized sequential design for the data acquisition process, 52 VA160 chips and 32 VATA160 chips have been applied in the flight model of the BGO calorimeter with radiation hardness assurance. Supported by Strategic Priority Research Program on Space Science of the Chinese Academy of Sciences (XDA04040202-4) and Fundamental Research Funds for the Central Universities (WK2030040048)

  7. Estimation of radiation effects in the front-end electronics of an ILC electromagnetic calorimeter

    Bartsch, V.; Postranecky, M.; Targett-Adams, C.; Warren, M.; Wing, M.

    2008-01-01

    The front-end electronics of the electromagnetic calorimeter of an International Linear Collider detector are situated in a radiation environment. This requires the effect of the radiation on the performance of the electronics, specifically FPGAs, to be examined. In this paper we study the flux, particle spectra and deposited doses at the front-end electronics of the electromagnetic calorimeter of a detector at the ILC. We also study the occupancy of the electromagnetic calorimeter. These estimates are compared with measurements, e.g. of the radiation damage of FPGAs, done elsewhere. The outcome of the study shows that the radiation doses and the annual flux is low enough to allow today's FPGAs to operate. The Single Event Upset rate, however, lies between 14 min and 12 h depending on the FPGA used and therefore needs to be considered in the design of the data acquisition system of the electromagnetic calorimeter. The occupancy is about 0.002 per bunch train not taking into account the effect of noise which depends on the choice of the detector

  8. Investigation on Effect of Material Hardness in High Speed CNC End Milling Process

    N. V. Dhandapani

    2015-01-01

    Full Text Available This research paper analyzes the effects of material properties on surface roughness, material removal rate, and tool wear on high speed CNC end milling process with various ferrous and nonferrous materials. The challenge of material specific decision on the process parameters of spindle speed, feed rate, depth of cut, coolant flow rate, cutting tool material, and type of coating for the cutting tool for required quality and quantity of production is addressed. Generally, decision made by the operator on floor is based on suggested values of the tool manufacturer or by trial and error method. This paper describes effect of various parameters on the surface roughness characteristics of the precision machining part. The prediction method suggested is based on various experimental analysis of parameters in different compositions of input conditions which would benefit the industry on standardization of high speed CNC end milling processes. The results show a basis for selection of parameters to get better results of surface roughness values as predicted by the case study results.

  9. Investigation on Effect of Material Hardness in High Speed CNC End Milling Process.

    Dhandapani, N V; Thangarasu, V S; Sureshkannan, G

    2015-01-01

    This research paper analyzes the effects of material properties on surface roughness, material removal rate, and tool wear on high speed CNC end milling process with various ferrous and nonferrous materials. The challenge of material specific decision on the process parameters of spindle speed, feed rate, depth of cut, coolant flow rate, cutting tool material, and type of coating for the cutting tool for required quality and quantity of production is addressed. Generally, decision made by the operator on floor is based on suggested values of the tool manufacturer or by trial and error method. This paper describes effect of various parameters on the surface roughness characteristics of the precision machining part. The prediction method suggested is based on various experimental analysis of parameters in different compositions of input conditions which would benefit the industry on standardization of high speed CNC end milling processes. The results show a basis for selection of parameters to get better results of surface roughness values as predicted by the case study results.

  10. Neurite regeneration in adult rat retinas exposed to advanced glycation end-products and regenerative effects of neurotrophin-4.

    Bikbova, Guzel; Oshitari, Toshiyuki; Yamamoto, Shuichi

    2013-10-09

    The purpose of this study was to determine the effect of low concentrations of advanced glycation end-products on neurite regeneration in isolated rat retinas, and to determine the effects of neurotrophin-4 on regeneration in advanced glycation end-products exposed retinas. Retinal explants of 4 adult Sprague-Dawley rats were cultured on collagen gel and were incubated in; (1) serum-free control culture media, (2) glucose-advanced glycation end-products-bovine serum albumin media, (3) glycolaldehyde-advanced glycation end-products-bovine serum albumin media, (4) glyceraldehyde-advanced glycation end-products-bovine serum albumin media, (5) glucose-advanced glycation end-products+neurotrophin-4 media, (6) glycolaldehyde-advanced glycation end-products+neurotrophin-4 media, or (7) glyceraldehyde-advanced glycation end-products+neurotrophin-4 supplemented culture media. After 7 days, the number of regenerating neurites from the explants was counted. Then, explants were fixed, cryosectioned, and stained for TUNEL. The ratio of TUNEL-positive cells to all cells in the ganglion cell layer was determined. Immunohistochemical examinations for the active-form of caspase-9 and apoptosis-inducing factor were performed. In retinas incubated with advanced glycation end-products containing media, the number of regenerating neurites were fewer than in retinas without advanced glycation end-products, and the number of TUNEL-positive cells and caspase-9- and apoptosis-inducing factor-immunopositive cells was significantly higher than in control media. Neurotrophin-4 supplementation increased the numbers of regenerating neuritis, and the number of TUNEL-positives, caspase-9-, and apoptosis-inducing factor-immunopositive cells were significantly fewer than that in advanced glycation end-products without neurotrophin-4 media. Low doses of advanced glycation end-products impede neurite regeneration in the rat retinas. Neurotrophin-4 significantly enhances neurite regeneration in

  11. Testing the effectiveness and the contribution of experimental supercharge (reversed) end-to-side nerve transfer.

    Nadi, Mustafa; Ramachandran, Sudheesh; Islam, Abir; Forden, Joanne; Guo, Gui Fang; Midha, Rajiv

    2018-05-18

    OBJECTIVE Supercharge end-to-side (SETS) transfer, also referred to as reverse end-to-side transfer, distal to severe nerve compression neuropathy or in-continuity nerve injury is gaining clinical popularity despite questions about its effectiveness. Here, the authors examined SETS distal to experimental neuroma in-continuity (NIC) injuries for efficacy in enhancing neuronal regeneration and functional outcome, and, for the first time, they definitively evaluated the degree of contribution of the native and donor motor neuron pools. METHODS This study was conducted in 2 phases. In phase I, rats (n = 35) were assigned to one of 5 groups for unilateral sciatic nerve surgeries: group 1, tibial NIC with distal peroneal-tibial SETS; group 2, tibial NIC without SETS; group 3, intact tibial and severed peroneal nerves; group 4, tibial transection with SETS; and group 5, severed tibial and peroneal nerves. Recovery was evaluated biweekly using electrophysiology and locomotion tasks. At the phase I end point, after retrograde labeling, the spinal cords were analyzed to assess the degree of neuronal regeneration. In phase II, 20 new animals underwent primary retrograde labeling of the tibial nerve, following which they were assigned to one of the following 3 groups: group 1, group 2, and group 4. Then, secondary retrograde labeling from the tibial nerve was performed at the study end point to quantify the native versus donor regenerated neuronal pool. RESULTS In phase I studies, a significantly increased neuronal regeneration in group 1 (SETS) compared with all other groups was observed, but with modest (nonsignificant) improvement in electrophysiological and behavioral outcomes. In phase II experiments, the authors discovered that secondary labeling in group 1 was predominantly contributed from the donor (peroneal) pool. Double-labeling counts were dramatically higher in group 2 than in group 1, suggestive of hampered regeneration from the native tibial motor neuron pool

  12. Peak and end effects in patients' daily recall of pain and fatigue: a within-subjects analysis.

    Schneider, Stefan; Stone, Arthur A; Schwartz, Joseph E; Broderick, Joan E

    2011-02-01

    Clinical research often relies on retrospective recall of symptom levels, but the information contained in these ratings is not well understood. The "peak-and-end rule" suggests that the most intense (peak) and final (end) moments of an experience disproportionately influence retrospective judgments, which may bias self-reports of somatic symptoms. This study examined the extent to which peak and end symptom levels systematically affect patients' day-to-day recall of pain and fatigue. Rheumatology patients (N = 97) completed 5 to 6 momentary ratings of pain and fatigue per day as well as a daily recall rating of these symptoms for 28 consecutive days. For pain, peak and end momentary ratings predicted daily recall of average pain beyond the actual average of momentary ratings. This effect was small, yet was confirmed in both between-person and within-person (repeated measures) analyses. For fatigue, neither peak nor end momentary symptoms significantly contributed to daily recall. Of note, the evidence for peak- and end-effects in recall of pain and fatigue varied significantly between individual patients. These findings suggest that peak- and end-effects create a small bias in recall reports of pain, but not fatigue. However, there are considerable individual differences in susceptibility to peak and end heuristics. The peak-end cognitive heuristic could bias end-of-day recall of pain and fatigue. An effect was shown for pain, but not for fatigue. The effects were small and were unlikely to substantially bias end-of-day assessments. Individuals were shown to differ in the degree that the heuristic was associated with recall. Copyright © 2011 American Pain Society. Published by Elsevier Inc. All rights reserved.

  13. Combined fishing and climate forcing in the southern Benguela upwelling ecosystem: an end-to-end modelling approach reveals dampened effects.

    Morgane Travers-Trolet

    Full Text Available The effects of climate and fishing on marine ecosystems have usually been studied separately, but their interactions make ecosystem dynamics difficult to understand and predict. Of particular interest to management, the potential synergism or antagonism between fishing pressure and climate forcing is analysed in this paper, using an end-to-end ecosystem model of the southern Benguela ecosystem, built from coupling hydrodynamic, biogeochemical and multispecies fish models (ROMS-N2P2Z2D2-OSMOSE. Scenarios of different intensities of upwelling-favourable wind stress combined with scenarios of fishing top-predator fish were tested. Analyses of isolated drivers show that the bottom-up effect of the climate forcing propagates up the food chain whereas the top-down effect of fishing cascades down to zooplankton in unfavourable environmental conditions but dampens before it reaches phytoplankton. When considering both climate and fishing drivers together, it appears that top-down control dominates the link between top-predator fish and forage fish, whereas interactions between the lower trophic levels are dominated by bottom-up control. The forage fish functional group appears to be a central component of this ecosystem, being the meeting point of two opposite trophic controls. The set of combined scenarios shows that fishing pressure and upwelling-favourable wind stress have mostly dampened effects on fish populations, compared to predictions from the separate effects of the stressors. Dampened effects result in biomass accumulation at the top predator fish level but a depletion of biomass at the forage fish level. This should draw our attention to the evolution of this functional group, which appears as both structurally important in the trophic functioning of the ecosystem, and very sensitive to climate and fishing pressures. In particular, diagnoses considering fishing pressure only might be more optimistic than those that consider combined effects

  14. Effects of feeding polydextrose on faecal characteristics, microbiota and fermentative end products in healthy adult dogs.

    Beloshapka, Alison N; Wolff, Amanda K; Swanson, Kelly S

    2012-08-01

    Polydextrose is a potential prebiotic, but has not been well tested in dogs. Thus, the objective of the present study was to determine the effects of polydextrose on faecal characteristics, microbial populations and fermentative end products in healthy adult dogs. A total of eight adult hound dogs (3.5 (sem 0.5) years; 20 (sem 0.5) kg) were randomly allotted to one of four test diets containing the following concentrations of polydextrose: (1) 0 % (control); (2) 0.5 %; (3) 1.0 %; or (4) 1.5 %. A Latin square design was used, with each treatment period lasting 14 d (days 0-10 adaptation; days 11-14 fresh and total faecal collection). All dogs were fed to maintain body weight. Data were evaluated for linear and quadratic effects using SAS software. Although apparent total tract DM digestibility was unaffected, total tract crude protein digestibility tended to decrease (P dogs.

  15. Effect of machining parameters on surface finish of Inconel 718 in end milling

    Sarkar Bapi

    2017-01-01

    Full Text Available Surface finish is an important criteria in machining process and selection of proper machining parameters is important to obtain good surface finish. In the present work effects of the machining parameters in end milling of Inconel 718 were investigated. Central composite design was used to design the total number of experiments. A Mathematical model for surface roughness has been developed using response surface methodology. In this study, the influence of cutting parameters such as cutting speed, feed rate and depth of cut on surface roughness was analyzed. The study includes individual effect of cutting parameters on surface roughness as well as their interaction. The analysis of variance (ANOVA was employed to find the validity of the developed model. The results show that depth of cut mostly affected the surface roughness. It is also observed that surface roughness values are comparable in both dry and wet machining conditions.

  16. Synapses of the rat end brain in response to flight effects

    Antipov, V.V.; Tikhonchuk, V.S.; Ushakov, I.B.; Fedorov, V.P.

    1988-01-01

    Using electron microscopy, synapses of different structures of the rat end brain related to cognitive and motor acts (sensorimotor cortex, caudate nucleus) as well as memory and behavior (hippocampus) were examined. Rats were exposed to ionizing radiation, superhigh frequency, hypoxia, hyperoxia, vibration and acceleration (applied separately or in combination) which have been traditionally in the focus of space and aviation medicine. Brain internuronal junctions were found to be very sensitive to the above effects, particularly ionizing radiation and hypoxia. Conversely, synapses were shown to be highly resistant to short-term hyperoxia and electromagnetic radiation. When combined effects were used, response of interneuronal junctions depended on the irradiation dose and order of application of radiation and other flight factors

  17. Attitudes of Dutch nurses towards their involvement in end-of-life decisions with a possible life-shortening effect.

    Albers, G.; Francke, A.L.; Veer, A.J. de; Onwuteaka-Philipsen, B.D.

    2012-01-01

    Background: Nurses are often involved in end-of-life decision making as they play an important role in caring for terminally ill patients. Aim: To investigate nurses’ attitudes towards their involvement in end-of-life decisions with a possible lifeshortening effect, and a possible relationship with

  18. Effectiveness of Agile Implementation Methods in Business Intelligence Projects from an End-user Perspective

    Anna Maria Misiak

    2016-06-01

    Full Text Available The global Business Intelligence (BI market grew by 10% in 2013 according to the Gartner Report. Today organizations require better use of data and analytics to support their business decisions. Internet power and business trend changes have provided a broad term for data analytics – Big Data. To be able to handle it and leverage a value of having access to Big Data, organizations have no other choice than to get proper systems implemented and working. However traditional methods are not efficient for changing business needs. The long time between project start and go-live causes a gap between initial solution blueprint and actual user requirements in the end of the project. This article presents the latest market trends in BI systems implementation by comparing Agile with traditional methods. It presents a case study provided in a large telecommunications company (20K employees and the results of a pilot research provided in the three large companies: telecommunications, digital, and insurance. Both studies prove that Agile methods might be more effective in BI projects from an end-user perspective and give first results and added value in a much shorter time compared to a traditional approach.

  19. Effect of Low Pressure End Conditions on Steam Power Plant Performance

    Ali Syed Haider

    2014-07-01

    Full Text Available Most of the electricity produced throughout the world today is from steam power plants and improving the performance of power plants is crucial to minimize the greenhouse gas emissions and fuel consumption. Energy efficiency of a thermal power plant strongly depends on its boiler-condenser operating conditions. The low pressure end conditions of a condenser have influence on the power output, steam consumption and efficiency of a plant. Hence, the objective this paper is to study the effect of the low pressure end conditions on a steam power plant performance. For the study each component was modelled thermodynamically. Simulation was done and the results showed that performance of the condenser is highly a function of its pressure which in turn depends on the flow rate and temperature of the cooling water. Furthermore, when the condenser pressure increases both net power output and plant efficiency decrease whereas the steam consumption increases. The results can be used to run a steam power cycle at optimum conditions.

  20. The Use of Open-Ended Questions with Giving Feedback (OEQGF) for Effective Mathematic Learning

    Sabilah, I.; Manoy, J. T.

    2018-01-01

    Feedback deals with giving information to students related to their task which is done through score of their achievement, reaction, and comments. Considering its hierarchy, task difficulty level consists of low, middle and high levels. The difficulty level of open-ended questions is middle to high. Open-ended question is a good way to train students’ knowledge. This research is a descriptive research which aims at describing teacher’s learning management, students’ activities, students’ learning achievement, and students’ responses in mathematic learning using OEQGF. The subject was a teacher of mathematics who teaches eighth graders, and students themselves. The research design used is one shot case study. The result shows that: management learning has been very well implemented by the teacher; every students’ activity has been carried out by students; the students’ learning achievement have reached the criteria of completeness, and the students’ responses can be considered as positive. Therefore, it can be concluded that mathematic learning using OEQGF is effective.

  1. AN INVESTIGATION OF THE EFFECT OF THE HOT END PLUGS ON THE EFFICIENCY OF THE RANQUE-HILSCH VORTEX TUBE

    MAZIAR ARJOMANDI

    2007-12-01

    Full Text Available The phenomenon of temperature distribution in confined steady rotating gas flows is called Ranque-Hilsch effect. The simple counter-flow vortex tube consists of a long hollow cylinder with tangential nozzle at one end for injecting compressed air. The flow inside the vortex tube can be described as rotating air, which moves in a spring-shaped vortex track. The peripheral flow moves toward the hot end where a hot end plug is placed and the axial flow, which is forced back by the plug, moves in the opposite direction toward the cold end. This paper focuses on the effect of the size of hot nozzle on the performance of the Ranque–Hilsch vortex tube. Series of plugs were used in the experiment in order to find the relationship between the diameter of hot end plug and the performance of the vortex tube.

  2. The effect of support springs in ends welded gap hollow YT-joint

    R. F. Vieira

    Full Text Available This paper presents an analysis on the effect of support springs in an ends circular hollow sections welded into a YT joint. The overall behavior and failure of the joint were characterized under axial compression of the lap brace. Two joint failure modes were identified: chord wall plastification (Mode A and cross-sectional chord buckling (Mode F in the region below the lap brace. The system was modeled with and without support springs using the numerical finite element program Ansys. Model results were compared with experimental data in terms of principal stress in the joint intersection. The finite element model without support springs proved to be more accurate than that with support springs.

  3. Cost-effectiveness of kidney transplantation compared with chronic dialysis in end-stage renal disease

    Diego Rosselli

    2015-01-01

    Full Text Available To estimate the costs and effectiveness measured in quality-adjusted life years (QALY of kidney transplantation compared with dialysis in adults suffering from end-stage renal disease from the perspective of the Colombian healthcare system, we designed a Markov model with monthly cycles over a five-year time horizon and eight transitional states, including death as an absorbing state. Transition probabilities were obtained from international registries, costs from different local sources [case studies, official tariffs (ISS 2001 + 35% for procedures and SISMED for medications]. Data were validated by an expert panel and we performed univariate, multivariate and probabilistic sensitivity analyses. Effectiveness indicators were months of life gained, months of dialysis averted and deaths prevented. The annual discount rate was 3% and the cost-utility threshold (willingness to pay was three times gross domestic product (GDP = USD 20,000 per QALY. The costs were adopted in US dollars (USD using the 2012 average exchange rate (1 USD = COP$ 1798. The discounted average total cost for five years was USD 76,718 for transplantation and USD 76,891 for dialysis, with utilities 2.98 and 2.10 QALY, respectively. Additionally, renal transplantation represented 6.9 months gained, 35 months in dialysis averted per patient and one death averted for each of the five patients transplanted in five years. We conclude that renal transplantation improves the overall survival rates and quality of life and is a cost-saving alternative compared with dialysis.

  4. The effect of rapid response teams on end-of-life care: A retrospective chart review

    Tam, Benjamin; Salib, Mary; Fox-Robichaud, Alison

    2014-01-01

    BACKGROUND: A subset of critically ill patients have end-of-life (EOL) goals that are unclear. Rapid response teams (RRTs) may aid in the identification of these patients and the delivery of their EOL care. OBJECTIVES: To characterize the impact of RRT discussion on EOL care, and to examine how a preprinted order (PPO) set for EOL care influenced EOL discussions and outcomes. METHODS: A single-centre retrospective chart review of all RRT calls (January 2009 to December 2010) was performed. The effect of RRT EOL discussions and the effect of a hospital-wide PPO set on EOL care was examined. Charts were from the Ontario Ministry of Health and Long-Term Care Critical Care Information Systemic database, and were interrogated by two reviewers. RESULTS: In patients whose EOL status changed following RRT EOL discussion, there were fewer intensive care unit (ICU) transfers (8.4% versus 17%; PEOL status following the introduction of an EOL PPO, from 20% (before) to 31% (after) (PEOL status following RRT-led EOL discussion was associated with reduced ICU transfers and enhanced access to palliative care services. Further study is required to identify and deconstruct barriers impairing timely and appropriate EOL discussions. PMID:25299222

  5. The in vitro effects of advanced glycation end products on basophil functions.

    Han, Kaiyu; Suzukawa, Maho; Yamaguchi, Masao; Sugimoto, Naoya; Nakase, Yuko; Toda, Takako; Nagase, Hiroyuki; Ohta, Ken

    2011-01-01

    Basophils are thought to play pivotal roles in the pathogenesis of allergic reactions, but their roles in inflammation associated with systemic abnormalities such as metabolic disorders remain largely unknown. Advanced glycation end products (AGEs) are potentially important substances produced in high-glucose disease conditions. In this in vitro study, we investigated whether the biological functions of human basophils can be influenced by AGEs. We analyzed the effects of AGEs on various functions and markers of human basophils, including CD11b expression, apoptosis, degranulation, and cytokine production. Flow cytometric analysis indicated that the level of the receptor for AGEs (RAGE) on the surface of freshly isolated basophils was very low but was clearly upregulated by IL-3. Apoptosis of basophils was induced by high concentrations of glycated albumin. Although glycated albumin failed to affect the level of surface CD11b expression or to trigger degranulation or production of IL-4 and IL-13 in basophils, it dose-dependently induced IL-6 and IL-8 secretion. AGEs seem to act on human basophils; they suppress the cells' longevity but elicit secretion of inflammatory cytokines. Through these biological changes, basophils might play some roles in inflammatory conditions associated with metabolic disorders presenting elevated levels of AGEs. Copyright © 2011 S. Karger AG, Basel.

  6. Clinical information systems end user satisfaction: the expectations and needs congruencies effects.

    Karimi, Faezeh; Poo, Danny C C; Tan, Yung Ming

    2015-02-01

    Prior research on information systems (IS) shows that users' attitudes and continuance intentions are associated with their satisfaction with information systems. As such, the increasing amount of investments in clinical information systems (CIS) signifies the importance of understanding CIS end users' (i.e., clinicians) satisfaction. In this study, we develop a conceptual framework to identify the cognitive determinants of clinicians' satisfaction formation. The disconfirmation paradigm serves as the core of the framework. The expectations and needs congruency models are the two models of this paradigm, and perceived performance is the basis of the comparisons in the models. The needs and expectations associated with the models are also specified. The survey methodology is adopted in this study to empirically validate the proposed research model. The survey is conducted at a public hospital and results in 112 and 203 valid responses (56% and 98% response rates) from doctors and nurses respectively. The partial least squares (PLS) method is used to analyze the data. The results of the study show that perceived CIS performance is the most influential factor on clinicians' (i.e., doctors and nurses) satisfaction. Doctors' expectations congruency is the next significant determinant of their satisfaction. Contrary to most previous findings, nurses' expectations and expectations congruency do not show a significant effect on their satisfaction. However, the needs congruency is found to significantly affect nurses' satisfaction. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Radiation induced Single Event Effects in the ATLAS MDT-ASD front-end chip

    Posch, C

    2002-01-01

    Single Event Effect (SEE) tests of the MDT-ASD, the ATLAS MDT front-end chip have been performed at the Harvard Cyclotron Lab. The MDT-ASD is an 8-channel drift tube read-out ASIC fabricated in a commercial 0.5um CMOS process (AMOS14TB). The chip contains a 53 bit register which holds the setup information and an associated shift register of the same length plus some additional control logic. 10 test devices were exposed to a 160 MeV proton beam with a fluence of 1.05E9 p.cm-2.s-1 up to >4.4E p.cm-2 per device. After a total fluence of 4.46E13 p.cm-2, 7 soft SEEs (non-permanent bit flips in the registers) and 0 hard/destructive SEE (e.g. latch-ups, SEL) had occurred. The simulated fluence for 10 years of LHC operation at nominal luminosity for worst case location MDT components is 2.67E11 h.cm-2. The rate of SEUs in the ASD setup register for all of ATLAS, derived from these numbers, is 2.4 per day. It is foreseen to update the active registers of the on-detector electronics at regular intervals. Depending on...

  8. Mass transport at rotating disk electrodes: effects of synthetic particles and nerve endings.

    Chiu, Veronica M; Lukus, Peter A; Doyle, Jamie L; Schenk, James O

    2011-11-01

    An unstirred layer (USL) exists at the interface of solids with solutions. Thus, the particles in brain tissue preparations possess a USL as well as at the surface of a rotating disk electrode (RDE) used to measure chemical fluxes. Time constraints for observing biological kinetics based on estimated thicknesses of USLs at the membrane surface in real samples of nerve endings were estimated. Liposomes, silica, and Sephadex were used separately to model the tissue preparation particles. Within a solution stirred by the RDE, both diffusion and hydrodynamic boundary layers are formed. It was observed that the number and size of particles decreased the following: the apparent diffusion coefficient excluding Sephadex, boundary layer thicknesses excluding silica, sensitivity excluding diluted liposomes (in agreement with results from other laboratories), limiting current potentially due to an increase in the path distance, and mixing time. They have no effect on the detection limit (6 ± 2 nM). The RDE kinetically resolves transmembrane transport with a timing of approximately 30 ms. Copyright © 2011 Elsevier Inc. All rights reserved.

  9. END effects on the n = 2 rotational instability in the reversed field theta-pinch

    Aso, Y.; Wu, Ch.; Himeno, S.; Hirano, K.

    1981-07-01

    It is observed that n = 2 rotational mode which appears in the field reversed configuration created by a theta-pinch can be stabilized if the ejected plasmas from the ends are guided out to the far ends of the apparatus by long axial solenoidal fields. This is understood from the fact that endshorting becomes no longer possible before the ejecting plasma tips reach to the ends. Measurement of plasma rotations just outside the separatrix suggests that both preferential diffusion loss and endshorting play a very important role for the n = 2 mode. (author)

  10. End Effects on the Linear Induction MHD Generator Calculated by Two-Sided Laplace Transform

    Engeln, F.; Peschka, W. [Deutsche Versuchsanstalt fuer Luft- und Raumfahrt e.V., Institut fuer Energiewandlung und Elektrische Antriebe, Stuttgart, Federal Republic of Germany (Germany)

    1966-11-15

    In induction MHD systems special problems occur where the flow enters or leaves the magnetic field. These problems are generally described as end effects. Large gradients of the magnetic field are present at the inlet and also at the outlet of an MHD induction engine, these generating electric current systems in the fluid which may spoil the performance characteristics of the generator due to the interaction with the primary field of the engine. The two-dimensional induction MHD generator of finite length, using a polyphase winding system to obtain a travelling magnetic field, is treated as a boundary value problem by two-sided Laplace transform. For simplicity incompressibility is assumed. The two- dimensional boundary value problem of the induction engine is solved for - {infinity} Less-Than-Over-Equal-To x Less-Than-Over-Equal-To {infinity}. x is parallel to the flow direction of the linear MHD generator. In the region 0 Less-Than-Over-Equal-To x Less-Than-Over-Equal-To L the magnetic travelling wave is sinusoidal with a cyclical frequency {omega} and a phase-velocity v{sub s}. At x = 0 the conducting incompressible working fluid enters the field region and leaves it at the point-x = L. Two mathematical methods can be used to solve the boundary value problem, the Fourier transform or the two-sided Laplace transform. The latter offers the advantage of representing a complex analytical function in the image space. Moreover, it is possible to obtain the characteristics of the generator in the image space (e. g. field configuration, power flow function, etc.). That implies a large simplification of mathematical treatment. The solution in the original space then is given by asymptotic expansion of the known image function. (author)

  11. Effects of hemodialysis therapy on sit-to-walk characteristics in end stage renal disease patients.

    Soangra, Rahul; Lockhart, Thurmon E; Lach, John; Abdel-Rahman, Emaad M

    2013-04-01

    Patients with end stage renal diseases (ESRD) undergoing hemodialysis (HD) have high morbidity and mortality due to multiple causes; one of which is dramatically higher fall rates than the general population. In spite of the multiple efforts aiming to decrease the high mortality and improve quality of life in ESRD patients, limited success has been achieved. If adequate interventions for fall prevention are to be achieved, the functional and mobility mechanisms consistent with falls in this population must be understood. Human movements such as sit-to-walk (STW) tasks are clinically significant, and analysis of these movements provides a meaningful evaluation of postural and locomotor performance in elderly patients with functional limitations indicative of fall risks. In order to assess the effects of HD therapy on fall risks, 22 sessions of both pre- and post-HD measurements were obtained in six ESRD patients utilizing customized inertial measurement units (IMU). IMU signals were denoised using ensemble empirical mode decomposition and Savistky-Golay filtering methods to detect relevant events for identification of STW phases. The results indicated that patients were slower to get out of the chair (as measured by trunk flexion angular accelerations, time to peak trunk flexion, and overall STW completion time) following the dialysis therapy session. STW is a frequent movement in activities of daily living, and HD therapy may influence the postural and locomotor control of these movements. The analysis of STW movement may assist in not only assessing a patient's physical status, but in identifying HD-related fall risk as well. This preliminary study presents a non-invasive method of kinematic measurement for early detection of increased fall risk in ESRD patients using portable inertial sensors for out-patient monitoring. This can be helpful in understanding the pathogenesis better, and improve awareness in health care providers in targeting interventions to

  12. Effect of dialysis on cerebral blood flow in depressive end-stage renal disease patients

    Nam, Hyun-Yeol; Kim, Seong-Jang; Song, Sang-Heon

    2011-01-01

    The aim of this study was to investigate regional cerebral blood flow (rCBF) changes of end-stage renal disease (ESRD) patients with depressive symptoms during dialysis. Fourteen patients with ESRD underwent Tc-99m ethylcysteinate dimer (Tc-99m ECD) brain single photon emission computed tomography (SPECT) and were evaluated the severity of depressive mood at pre-dialytic period and at least 6 months after dialysis initiation. rCBF was analyzed using statistical parametric mapping (SPM) in brain SPECT image. The responder was defined as a decrease of ≥25% in Hamilton Depression Rating Scale (HDRS) score from baseline HDRS score. Pre-dialysis brain SPECT did not show any rCBF differences between responders and non-responders. The follow-up brain SPECT revealed a significant higher perfusion in left middle temporal gyrus of responder group when compared with non-responder (hemisphere coordinate X, Y, Z; -58, -2, -16, peak Z=3.36, p=0.046). In responder, a significant increase in rCBF was found in right parahippocampal gyrus (hemisphere coordinate X, Y, Z; 30, -40, -14, peak Z=3.51, p=0.043). In non-responder, there were significant decreases in rCBF in left superior frontal gyrus (hemisphere coordinate X, Y, Z; -22, 30, 42, peak Z=3.86, p=0.032) and right orbitofrontal cortex (hemisphere coordinate X, Y, Z; 10, 58, -6, peak Z=3.81, p=0.046). The present findings showed the characteristic patterns of rCBF changes in depressive ESRD patients having maintenance dialysis. Further investigations in brain blood flow and glucose metabolism are needed to elucidate the effect of dialysis itself and the difference of according to dialysis modality in patients having depression and ESRD. (author)

  13. Effect of renal replacement therapy on viscosity in end-stage renal disease patients.

    Feriani, M; Kimmel, P L; Kurantsin-Mills, J; Bosch, J P

    1992-02-01

    Viscosity, an important determinant of microcirculatory hemodynamics, is related to hematocrit (HCT), and may be altered by renal failure or its treatment. To assess these factors, we studied the effect of dialysis on the viscosity of whole blood, plasma, and reconstituted 70% HCT blood of eight continuous ambulatory peritoneal dialysis (CAPD) and nine hemodialysis (HD) patients under steady shear flow conditions at different shear rates, before and after dialysis, compared with nine normal subjects. The density of the red blood cells (RBCs), a marker of cell hydration, was measured in HD patients by a nonaqueous differential floatation technique. Whole blood viscosity was higher in controls than patients, and correlated with HCT before treatment (P less than 0.05) at shear rates of 11.5 to 230 s-1) in HD patients, and 23 to 230 s-1 in all end-stage renal disease (ESRD) patients. In contrast, whole blood viscosity correlated with HCT in CAPD patients only at the lowest shear rates (2.3 and 5.75 s-1, P less than 0.05). Plasma viscosity was higher in CAPD patients than both HD patients before treatment and controls (P less than 0.05, analysis of variance [ANOVA]), despite lower plasma total protein, albumin, and similar fibrinogen concentration compared with HD patients. When all samples were reconstituted to 70% HCT, CAPD patients had higher whole blood viscosity than control subjects'. The high HCT blood viscosity of the ESRD patients was higher than control subjects' at capillary shear rates, suggesting increased RBC aggregation and decreased RBC deformability in patients with renal disease.(ABSTRACT TRUNCATED AT 250 WORDS)

  14. End-threaded intramedullary positive profile screw ended self-tapping pin (Admit pin) - A cost-effective novel implant for fixing canine long bone fractures.

    Chanana, Mitin; Kumar, Adarsh; Tyagi, Som Prakash; Singla, Amit Kumar; Sharma, Arvind; Farooq, Uiase Bin

    2018-02-01

    The current study was undertaken to evaluate the clinical efficacy of end-threaded intramedullary pinning for management of various long bone fractures in canines. This study was conducted in two phases, managing 25 client-owned dogs presented with different fractures. The technique of application of end-threaded intramedullary pinning in long bone fractures was initially standardized in 6 clinical patients presented with long bone fractures. In this phase, end-threaded pins of different profiles, i.e., positive and negative, were used as the internal fixation technique. On the basis of results obtained from standardization phase, 19 client-owned dogs clinically presented with different fractures were implanted with end-threaded intramedullary positive profile screw ended self-tapping pin in the clinical application phase. The patients, allocated randomly in two groups, when evaluated postoperatively revealed slight pin migration in Group-I (negative profile), which resulted in disruption of callus site causing delayed union in one case and large callus formation in other two cases whereas no pin migration was observed in Group-II (positive profile). Other observations in Group-I was reduced muscle girth and delayed healing time as compared to Group-II. In clinical application, phase 21 st and 42 nd day post-operative radiographic follow-up revealed no pin migration in any of the cases, and there was no bone shortening or fragment collapse in end-threaded intramedullary positive profile screw ended self-tapping pin. The end-threaded intramedullary positive profile screw ended self-tapping pin used for fixation of long bone fractures in canines can resist pin migration, pin breakage, and all loads acting on the bone, i.e., compression, tension, bending, rotation, and shearing to an extent with no post-operative complications.

  15. End shape effects on the mθ=1 diocotron instability in hollow electron columns

    Kabantsev, A. A.; Driscoll, C. F.

    1999-01-01

    Magnetically confined hollow columns of electrons exhibit a robust exponential m θ =1 diocotron instability, whereas standard 2-D fluid theory predicts at most algebraic growth. This discrepancy suggests that experimental subtleties such as finite axial length of the plasma column must be considered. Here, we present a systematic analysis of our experiments to determine the detailed influence of the plasma end curvature on the observed diocotron instability. Observed dependencies of unstable mode frequency, growth rate and spatial eigenfunction as a function of the plasma end curvature are in quantitative (factor-of-two) agreement with recent quasi-2D extension of the fluid theory

  16. The Effect of Contextualized Conversational Feedback in a Complex Open-Ended Learning Environment

    Segedy, James R.; Kinnebrew, John S.; Biswas, Gautam

    2013-01-01

    Betty's Brain is an open-ended learning environment in which students learn about science topics by teaching a virtual agent named Betty through the construction of a visual causal map that represents the relevant science phenomena. The task is complex, and success requires the use of metacognitive strategies that support knowledge acquisition,…

  17. Effect of collagen turnover on the accumulation of advanced glycation end products

    Verzijl, N.; Degroot, J.; Thorpe, S. R.; Bank, R. A.; Shaw, J. N.; Lyons, T. J.; Bijlsma, J. W.; Lafeber, F. P.; Baynes, J. W.; TeKoppele, J. M.

    2000-01-01

    Collagen molecules in articular cartilage have an exceptionally long lifetime, which makes them susceptible to the accumulation of advanced glycation end products (AGEs). In fact, in comparison to other collagen-rich tissues, articular cartilage contains relatively high amounts of the AGE

  18. Global economic growth and expected returns around the world: The end-of-the-year effect

    Møller, Stig Vinther; Rangvid, Jesper

    2017-01-01

    Global economic growth at the end of the year strongly predicts returns from a wide spectrum of international assets, such as global, regional, and individual-country stocks, FX, and commodities. Global economic growth at other times of the year does not predict international returns. Low growth...

  19. Whole wheat bread: Effect of bran fractions on dough and end-product quality

    Consumption of whole-wheat based products is encouraged due to its important nutritional elements that beneficial to human health. However, processing of whole-wheat based products, such as whole-wheat bread, results in poor end-product quality. Bran was postulated as the major problem. In this stud...

  20. Effect of dietary fatty acid saturation on egg production at end-of-lay ...

    During weeks 58, 62, 66, 70 and 74 of age (end-of-lay period), all eggs produced were recorded and individually weighed while feed intake, as well as body weights of birds, were determined. Data for the respective collection weeks were pooled to calculate and statistical analyse production parameter means for the ...

  1. Temperature effect on formation of advanced glycation end products in infant formula milk powder

    Zhu, Ru-Gang; Cheng, Hong; Li, Li

    2018-01-01

    For a standard infant formula milk powder, browning reactions were shown to become limiting for shelflife for storage at higher temperature rather than lipid oxidation. Advanced glycation end (AGE) products were found in the temperature range 65e115 C to have an energy of activation...

  2. Rounded leaf end effect of multileaf collimator on penumbra width and radiation field offset: an analytical and numerical study

    Zhou, Dong; Zhang, Hui; Ye, Peiqing

    2015-01-01

    Penumbra characteristics play a significant role in dose delivery accuracy for radiation therapy. For treatment planning, penumbra width and radiation field offset strongly influence target dose conformity and organ at risk sparing. In this study, we present an analytical and numerical approach for evaluation of the rounded leaf end effect on penumbra characteristics. Based on the rule of half-value layer, algorithms for leaf position calculation and radiation field offset correction were developed, which were advantageous particularly in dealing with large radius leaf end. Computer simulation was performed based on the Monte Carlo codes of EGSnrc/BEAMnrc, with groups of leaf end radii and source sizes. Data processing technique of curve fitting was employed for deriving penumbra width and radiation field offset. Results showed that penumbra width increased with source size. Penumbra width curves for large radius leaf end were U-shaped. This observation was probably related to the fact that radiation beams penetrated through the proximal and distal leaf sides. In contrast, source size had negligible impact on radiation field offset. Radiation field offsets were found to be constant both for analytical method and numerical simulation. However, the overall resulting values of radiation field offset obtained by analytical method were slightly smaller compared with Monte Carlo simulation. The method we proposed could provide insight into the investigation of rounded leaf end effects on penumbra characteristics. Penumbra width and radiation field offset calibration should be carefully performed to commission multileaf collimator for intensity modulated radiotherapy

  3. Perceived effectiveness of environmental decision support systems in participatory planning: Evidence from small groups of end-users

    Inman, D.; Blind, M.; Ribarova, I.; Krause, A.; Roosenschoon, O.R.; Kassahun, A.; Scholten, H.; Arampatzis, G.; Abrami, G.; McIntosh, B.S.; Jeffrey, P.

    2011-01-01

    The challenges associated with evaluating the effectiveness of environmental decision support systems (EDSS) based on the perceptions of only a small sample of end-users are well understood. Although methods adopted from Management Information Systems (MISs) evaluation research have benefited from

  4. Effects of preservation conditions of canine feces on in vitro gas production kinetics and fermentation end-products

    Bosch, G.; Wrigglesworth, D.J.; Cone, J.W.; Pellikaan, W.F.; Hendriks, W.H.

    2013-01-01

    This study investigated the effect of chilling and freezing (for 24 h) canine feces on in vitro gas production kinetics and fermentation end-product profiles from carbohydrate-rich (in vitro run 1) and protein-rich substrates (in vitro run 2). Feces were collected from 3 adult Retriever-type dogs

  5. Constraints on grip selection in hemiparetic cerebral palsy: effects of lesional side, end-point accuracy, and context.

    Steenbergen, Bert; Meulenbroek, Ruud G J; Rosenbaum, David A

    2004-04-01

    This study was concerned with selection criteria used for grip planning in adolescents with left or right hemiparetic cerebral palsy. In the first experiment, we asked participants to pick up a pencil and place the tip in a pre-defined target region. We varied the size of the target to test the hypothesis that increased end-point precision demands would favour the use of a grip that affords end-state comfort. In the second experiment, we studied grip planning in three task contexts that were chosen to let us test the hypothesis that a more functional task context would likewise promote the end-state comfort effect. When movements were performed with the impaired hand, we found that participants with right hemiparesis (i.e., left brain damage) aimed for postural comfort at the start rather than at the end of the object-manipulation phase in both experiments. By contrast, participants with left hemiparesis (i.e., right brain damage) did not favour a particular selection criterion with the impaired hand in the first experiment, but aimed for postural comfort at the start in the second experiment. When movements were performed with the unimpaired hand, grip selection criteria again differed for right and left hemiparetic participants. Participants with right hemiparesis did not favour a particular selection criterion with the unimpaired hand in the first experiment and only showed the end-state comfort effect in the most functional tasks of the second experiment. By contrast, participants with left hemiparesis showed the end-state comfort effect in all conditions of both experiments. These data suggest that the left hemisphere plays a special role in action planning, as has been recognized before, and that one of the deficits accompanying left brain damage is a deficit in forward movement planning, which has not been recognized before. Our findings have both theoretical and clinical implications.

  6. Effectiveness of group cognitive behavioral therapy with mindfulness in end-stage renal disease hemodialysis patients

    Bo Kyung Sohn; Yun Kyu Oh; Jung-Seok Choi; Jiyoun Song; Ahyoung Lim; Jung Pyo Lee; Jung Nam An; Hee-Jeong Choi; Jae Yeon Hwang; Hee-Yeon Jung; Jun-Young Lee; Chun Soo Lim

    2018-01-01

    Background : Many patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD) experience depression. Depression influences patient quality of life (QOL), dialysis compliance, and medical comorbidity. We developed and applied a group cognitive behavioral therapy (CBT) program including mindfulness meditation for ESRD patients undergoing HD, and measured changes in QOL, mood, anxiety, perceived stress, and biochemical markers. Methods : We conducted group CBT over a 12-week period...

  7. The End

    Hasse Jørgensen, Stina

    2016-01-01

    Operaen THE END af den japanske komponist og DJ, Keiichiro Shibuya, skubber radikalt til publikums forventninger om, hvad en opera kan og skal være. THE END byder på 3D animation, surround sound, elektronisk glitch og syntetiske stemmer i en kompromisløs virtuel forestilling med det japanske...

  8. Effect of Variant End of Injection Period on Combustion Process of Biodiesel Combustion

    Khalid Amir

    2016-01-01

    Full Text Available Biodiesel is an alternative fuel as a replacement to the standard diesel fuel in combustion diesel engine. The biodiesel fuel has a significantly influences throughout the combustion process and exhaust emission. The purpose of this research is to investigate the combustion process behavior during the End of Injection (EOI period and operates under variant conditions using Rapid Compression Machine (RCM. Experimental of RCM is used to simulate a combustion process and combustion characteristics of diesel engine combustion. Three types of biodiesel blend which are B5, B10 and B15 were tested at several injection pressures of 80 MPa, 90 MPa and 130 MPa under different ambient temperatures, 750 K to 1100 K. The results of this study showed that the ignition delay slightly reduced with increasing the content of biodiesel blends from B5, B10 and B15 and became more shorten as the injection pressure been enhanced. As the injection pressure increased, the behavior of combustion pressure at end of injection is reduced, radically increased the NOX emission. It is noted that the process of combustion at the end of injection increased as the ambient temperature is rising. In fact, higher initial ambient temperature improved the fuel atomization and mixing process. Under the biodiesel combustion with higher ambient temperature condition, the exhaust emission of CO, O2, and HC became less but increased in NOX emission. Besides, increased in blends of biodiesel ratio are found to enhance the combustion process, resulted a decreased in HC emissions.

  9. Measurements of bundle end flux peaking effects in 37-element CANDU PHW fuel

    French, P.M.

    1977-10-01

    Thermal neutron bundle end flux peaking factors have been measured in fresh 37-element Bruce reactor natural UO 2 clusters in heavy water moderator, both with and without staggered plenums at the fuel stack ends, in representative elements throughout the clusters. The measurements were made at a square lattice pitch of 28.58 cm with heavy water coolant. The results indicate that outer element peaking factors are 1.142 +- 0.009 for bundles containing no plenums, and 1.155 +- 0.006 and 1.177 +- 0.006 at the non-plenum and plenum element ends respectively, for bundles containing staggered plenums, irrespective of the azimuthal orientation between pairs of bundles. Measurements are also reported for bundles containing plenums in every outer element, for bundles separated by a stainless steel flux suppressor, for longer graphite plenums, and for changes in plenum and bundle gap lengths. Some theoretical comparisons with the results, reported by other authors, have been summarized. (author)

  10. The effectiveness of adhesives on the retention of mandibular free end saddle partial dentures: An in vitro study.

    Quiney, Daniel; Nishio Ayre, Wayne; Milward, Paul

    2017-07-01

    Existing in vitro methods for testing denture adhesives do not fully replicate the complex oral geometries and environment; and in vivo methods are qualitative, prone to bias and not easily reproducible. The purpose of this study was to develop a novel, quantitative and more accurate model to test the effect of adhesives on the retentive force of mandibular free end saddle partial dentures. An in vitro model was developed based on an anatomically accurate cast of a clinical case. Experimentally, the amount of adhesive was varied (0.2g-1g) and the tensile force required for displacement was measured. Different commercially available adhesives were then tested at the optimum volume using the in vitro model. A 3D finite element model of the denture was used to assess how the forces to induce denture displacement varied according to the position of the force along the saddle length. The mass of adhesive was found to significantly alter retention forces, with 0.4-0.7g being the optimum range for this particular scenario. Use of adhesives significantly improved mandibular free end saddle partial denture retention with the worst performing adhesive increasing retention nine-fold whilst the best performing adhesive increased retention twenty three-fold. The finite element model revealed that 77% more force was required to displace the denture by positioning forces towards the mesial end of the saddle compared to the distal end. An in vitro denture adhesive model was developed, which demonstrated that mass of adhesive plays a significant role in enhancing denture retention and supported the design principle of placing as few teeth as clinically necessary on the distal end of the free end saddles. Limiting the position of teeth on free end saddles to the mesial and mid portion of the saddle will reduce displacements caused by mastication. The movement of mandibular free end saddle partial dentures can be restricted with the use of denture adhesives. Altering the mass of

  11. Genotype, environment, seeding rate, and top-dressed nitrogen effects on end-use quality of modern Nebraska winter wheat.

    Bhatta, Madhav; Regassa, Teshome; Rose, Devin J; Baenziger, P Stephen; Eskridge, Kent M; Santra, Dipak K; Poudel, Rachana

    2017-12-01

    Fine-tuning production inputs such as seeding rate, nitrogen (N), and genotype may improve end-use quality of hard red winter wheat (Triticum aestivium L.) when growing conditions are unpredictable. Studies were conducted at the Agronomy Research Farm (ARF; Lincoln, NE, USA) and the High Plains Agricultural Laboratory (HPAL; Sidney, NE, USA) in 2014 and 2015 in Nebraska, USA, to determine the effects of genotype (6), environment (4), seeding rate (3), and flag leaf top-dressed N (0 and 34 kg N ha -1 ) on the end-use quality of winter wheat. End-use quality traits were influenced by environment, genotype, seeding rate, top-dressed N, and their interactions. Mixograph parameters had a strong correlation with grain volume weight and flour yield. Doubling the recommended seeding rate and N at the flag leaf stage increased grain protein content by 8.1% in 2014 and 1.5% in 2015 at ARF and 4.2% in 2014 and 8.4% in 2015 at HPAL. The key finding of this research is that increasing seeding rates up to double the current recommendations with N at the flag leaf stage improved most of the end-use quality traits. This will have a significant effect on the premium for protein a farmer could receive when marketing wheat. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  12. Comparative Effectiveness of Usual Source of Care Approaches to Improve End-of-Life Outcomes for Children With Intellectual Disability.

    Lindley, Lisa C; Cozad, Melanie J

    2017-09-01

    Children with intellectual disability (ID) are at risk for adverse end-of-life outcomes including high emergency room utilization and hospital readmissions, along with low hospice enrollment. The objective of this study was to compare the effectiveness of usual source of care approaches to improve end-of-life outcomes for children with ID. We used longitudinal California Medicaid claims data. Children were included who were 21 years with fee-for-service Medicaid claims, died between January 1, 2007, and December 31, 2010, and had a moderate-to-profound ID diagnosis. End-of-life outcomes (i.e., hospice enrollment, emergency room utilization, hospital readmissions) were measured via claims data. Our treatments were usual source of care (USC) only vs. usual source of care plus targeted case management (USC plus TCM). Using instrumental variable analysis, we compared the effectiveness of treatments on end-of-life outcomes. Ten percent of children with ID enrolled in hospice, 73% used the emergency room, and 20% had three or more hospital admissions in their last year of life. USC plus TCM relative to USC only had no effect on hospice enrollment; however, it significantly reduced the probability of emergency room utilization (B = -1.29, P life outcomes for children with ID. Further study of the extent of UCS and TCM involvement in reducing emergency room utilization and hospital readmissions at end of life is needed. Copyright © 2017 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  13. Framing Effects on End-of-Life Preferences Among Latino Elders.

    Vélez Ortiz, Daniel; Martinez, Rubén O; Espino, David V

    2015-01-01

    This study compared how the presentation of end-of-life (EOL) choices influences responses by Latino and White older adults relative to resuscitation preferences. The authors apply prospect theory, which deals with decision making based on how choices are framed. Participants were presented with differently ordered questions framing a resuscitation scenario and asked to rate their preferences. Results show that Latino participants were significantly influenced by the framing order of treatment options with regard to resuscitation while Whites were not. Health professionals need to be aware that the ways they present EOL options are likely to affect the choices of Latino older adults. Further research is needed with Latino subgroups.

  14. Retail margins and the effects of an integrated Nordic end user market for electricity

    Damsgaard, Niclas; Roempoetti, Marie

    2007-09-15

    impact of these effects on the customers' total price has not been assessed. Furthermore, it is possible that the customers can gain from receiving offers that are more adapted to their needs since a larger market provides better possibilities for market segmentation. The starting point for this project is an assumption that the customers can gain from a common Nordic market through reduced prices (or reduced margins). The question is thus: Can we expect that an integrated Nordic retail market for electricity will decrease the retail margins? In order to answer this question we study the existing retail margins and try to explain the differences in margins. We then analyse and assess whether an integrated Nordic market is likely to affect these margins. The main assumption is than that the reduced margins would come from an increased competitive pressure. In addition to reduced margins, there are several other possible benefits for the customers, e.g. improved competition and services, reduced costs, improvements in regulations and a better functioning wholesale market. This is discussed qualitatively in an adjacent report (Elforsk report 07:48). We find that it is not likely that an integrated Nordic retail market will increase the competitive pressure and in that way substantially reduce the retail margins. There might be some possibilities for reduced margins, at least in some countries and for some customer segments but the margins are generally relatively small. More importantly, the national retail markets are not very concentrated and a Nordic retail market will not dilute market power in the same way as is the case for the wholesale market. The price benefits for the customers can thus be expected to be modest. This conclusion does however not imply that our recommendation is not to pursue an integrated Nordic end-user market for electricity, but only that reduced retail margins probably is not a particularly strong argument for this

  15. Examining the nonparametric effect of drivers' age in rear-end accidents through an additive logistic regression model.

    Ma, Lu; Yan, Xuedong

    2014-06-01

    This study seeks to inspect the nonparametric characteristics connecting the age of the driver to the relative risk of being an at-fault vehicle, in order to discover a more precise and smooth pattern of age impact, which has commonly been neglected in past studies. Records of drivers in two-vehicle rear-end collisions are selected from the general estimates system (GES) 2011 dataset. These extracted observations in fact constitute inherently matched driver pairs under certain matching variables including weather conditions, pavement conditions and road geometry design characteristics that are shared by pairs of drivers in rear-end accidents. The introduced data structure is able to guarantee that the variance of the response variable will not depend on the matching variables and hence provides a high power of statistical modeling. The estimation results exhibit a smooth cubic spline function for examining the nonlinear relationship between the age of the driver and the log odds of being at fault in a rear-end accident. The results are presented with respect to the main effect of age, the interaction effect between age and sex, and the effects of age under different scenarios of pre-crash actions by the leading vehicle. Compared to the conventional specification in which age is categorized into several predefined groups, the proposed method is more flexible and able to produce quantitatively explicit results. First, it confirms the U-shaped pattern of the age effect, and further shows that the risks of young and old drivers change rapidly with age. Second, the interaction effects between age and sex show that female and male drivers behave differently in rear-end accidents. Third, it is found that the pattern of age impact varies according to the type of pre-crash actions exhibited by the leading vehicle. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Cost-effective evolution of research prototypes into end-user tools: The MACH case study

    Störrle, Harald

    2017-01-01

    's claim by fellow scientists, and (3) demonstrate the utility and value of the research contribution to any interested parties. However, turning an exploratory prototype into a “proper” tool for end-users often entails great effort. Heavyweight mainstream frameworks such as Eclipse do not address...... this issue; their steep learning curves constitute substantial entry barriers to such ecosystems. In this paper, we present the Model Analyzer/Checker (MACH), a stand-alone tool with a command-line interpreter. MACH integrates a set of research prototypes for analyzing UML models. By choosing a simple...... command line interpreter rather than (costly) graphical user interface, we achieved the core goal of quickly deploying research results to a broader audience while keeping the required effort to an absolute minimum. We analyze MACH as a case study of how requirements and constraints in an academic...

  17. Effect of filling ratio on premixed methane/air explosion in an open-end pipe

    Chang Guo

    2016-06-01

    Full Text Available The propagation characteristics of premixed methane/air explosion under different filling ratios (20%, 30%, 40%, 50%, 60%, and 100% were studied using an experimental system. The results indicate that the peak overpressure showed a decreasing trend at the initial stage but then showed an increasing trend until reaching its maximum value under different filling ratios. As the explosion propagated to the open end, the overpressure showed a downtrend. At this point, the flame speed initially increased along the pipe but then dropped dramatically. In addition, the explosion overpressure and flame speed increased with the increase of filling ratio. However, when the filling ratio reached 50%, the explosion overpressure and flame speed tended to be stable and the increase was not obvious. These results will be of great importance in evaluating the explosive damage to equipment and human personnel working in coal mines or other chemical industries.

  18. Temperature effects on tunable cw Alexandrite lasers under diode end-pumping.

    Kerridge-Johns, William R; Damzen, Michael J

    2018-03-19

    Diode pumped Alexandrite is a promising route to high power, efficient and inexpensive lasers with a broad (701 nm to 858 nm) gain bandwidth; however, there are challenges with its complex laser dynamics. We present an analytical model applied to experimental red diode end-pumped Alexandrite lasers, which enabled a record 54 % slope efficiency with an output power of 1.2 W. A record lowest lasing wavelength (714 nm) and record tuning range (104 nm) was obtained by optimising the crystal temperature between 8 °C and 105 °C in the vibronic mode. The properties of Alexandrite and the analytical model were examined to understand and give general rules in optimising Alexandrite lasers, along with their fundamental efficiency limits. It was found that the lowest threshold laser wavelength was not necessarily the most efficient, and that higher and lower temperatures were optimal for longer and shorter laser wavelengths, respectively. The pump excited to ground state absorption ratio was measured to decrease from 0.8 to 0.7 by changing the crystal temperature from 10 °C to 90 °C.

  19. Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells

    Huang, J.-S.; Chuang, L.-Y.; Guh, J.-Y.; Yang, Y.-L.; Hsu, M.-S.

    2008-01-01

    Mounting evidence indicates that advanced glycation end products (AGE) play a major role in the development of diabetic nephropathy (DN). Taurine is a well documented antioxidant agent. To explore whether taurine was linked to altered AGE-mediated renal tubulointerstitial fibrosis in DN, we examined the molecular mechanisms of taurine responsible for inhibition of AGE-induced hypertrophy in renal tubular epithelial cells. We found that AGE (but not non-glycated BSA) caused inhibition of cellular mitogenesis rather than cell death by either necrosis or apoptosis. There were no changes in caspase 3 activity, bcl-2 protein expression, and mitochondrial cytochrome c release in BSA, AGE, or the antioxidant taurine treatments in these cells. AGE-induced the Raf-1/extracellular signal-regulated kinase (ERK) activation was markedly blocked by taurine. Furthermore, taurine, the Raf-1 kinase inhibitor GW5074, and the ERK kinase inhibitor PD98059 may have the ability to induce cellular proliferation and cell cycle progression from AGE-treated cells. The ability of taurine, GW5074, or PD98059 to inhibit AGE-induced hypertrophy was verified by the observation that it significantly decreased cell size, cellular hypertrophy index, and protein levels of RAGE, p27 Kip1 , collagen IV, and fibronectin. The results obtained in this study suggest that taurine may serve as the potential anti-fibrotic activity in DN through mechanism dependent of its Raf-1/ERK inactivation in AGE-induced hypertrophy in renal tubular epithelial cells

  20. Effectiveness of group cognitive behavioral therapy with mindfulness in end-stage renal disease hemodialysis patients.

    Sohn, Bo Kyung; Oh, Yun Kyu; Choi, Jung-Seok; Song, Jiyoun; Lim, Ahyoung; Lee, Jung Pyo; An, Jung Nam; Choi, Hee-Jeong; Hwang, Jae Yeon; Jung, Hee-Yeon; Lee, Jun-Young; Lim, Chun Soo

    2018-03-01

    Many patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD) experience depression. Depression influences patient quality of life (QOL), dialysis compliance, and medical comorbidity. We developed and applied a group cognitive behavioral therapy (CBT) program including mindfulness meditation for ESRD patients undergoing HD, and measured changes in QOL, mood, anxiety, perceived stress, and biochemical markers. We conducted group CBT over a 12-week period with seven ESRD patients undergoing HD and suffering from depression. QOL, mood, anxiety, and perceived stress were measured at baseline and at weeks 8 and 12 using the World Health Organization Quality of Life scale, abbreviated version (WHOQOL-BREF), the Beck Depression Inventory II (BDI-II), the Hamilton Rating Scale for Depression (HAM-D), the Beck Anxiety Inventory (BAI), and the Perceived Stress Scale (PSS). Biochemical markers were measured at baseline and after 12 weeks. The Temperament and Character Inventory was performed to assess patient characteristics before starting group CBT. The seven patients showed significant improvement in QOL, mood, anxiety, and perceived stress after 12 weeks of group CBT. WHOQOL-BREF and the self-rating scales, BDI-II and BAI, showed continuous improvement across the 12-week period. HAM-D scores showed significant improvement by week 8; PSS showed significant improvement after week 8. Serum creatinine levels also improved significantly following the 12 week period. In this pilot study, a CBT program which included mindfulness meditation enhanced overall mental health and biochemical marker levels in ESRD patients undergoing HD.

  1. Effects of Cinnamon Consumption on Glycemic Indicators, Advanced Glycation End Products, and Antioxidant Status in Type 2 Diabetic Patients

    Behrouz Talaei

    2017-09-01

    Full Text Available The aim of the current study was to determine the effect of a daily intake of three grams of cinnamon over eight weeks on glycemic indicators, advanced glycation end products, and antioxidant status in patients with type 2 diabetes. In a double-blind, randomized, placebo controlled clinical trial study, 44 patients with type 2 diabetes, aged 57 ± 8 years, were randomly assigned to take either a three g/day cinnamon supplement (n = 22 or a placebo (n = 22 for eight weeks. We measured the fasting blood glucose, insulin, hemoglobinbA1c, homeostasis model assessment for insulin resistance (HOMA-IR, carboxymethyl lysine, total antioxidant capacity, and malondialdehyde levels at the beginning and the end of the study. Thirty-nine patients (20 in the intervention group and 19 in the control group completed the study. After an eight-week intervention, changes in the level of fasting blood glucose, insulin, hemoglobinbA1c, HOMA-IR, carboxymethyl lysine, total antioxidant capacity, and malondialdehyde were not significant in either group, nor were any significant differences between groups observed in these glycemic and inflammatory indicators at the end of the intervention. Our study revealed that cinnamon supplementation had no significant effects on glycemic and inflammatory indicators in patients with type 2 diabetes.

  2. To end life or not to prolong life: the effect of message framing on attitudes toward euthanasia.

    Gamliel, Eyal

    2013-05-01

    People ascribe "euthanasia" different values and view it differently. This study hypothesized that a different framing of objectively the same euthanasia situations would affect people's attitudes toward it. Indeed, "positive" framing of euthanasia as not prolonging life resulted in more support for both passive and active euthanasia relative to "negative" framing of the objectively same situations as ending life. Two experiments replicated this pattern using either continuous measures of attitude or dichotomous measures of choice. The article offers two theoretical explanations for the effect of message framing on attitudes toward euthanasia, discusses implications of this effect, and suggests future research.

  3. The Effect of an Open-Ended Design Experience on Student Achievement in an Engineering Laboratory Course

    Matthew Cullin

    2017-11-01

    Full Text Available This study explores the effect of incorporating an Open-Ended Design Experience (OEDE into an undergraduate materials science laboratory taken by third-year mechanical engineering students. The focus of the OEDE was carbon fiber reinforced plastics and sandwich structures. The results indicate that the incorporation of OEDE’s in laboratory courses produces significant benefits in terms of student engagement, participation, and perception of competence. In addition, the OEDE was found to enhance students’ ability to apply related concepts as compared to non-OEDE lab activities. The authors conclude that the incorporation of OEDE’s can increase the effectiveness of engineering laboratory courses.

  4. EFFECT OF THINNING AND FERTILIZATION ON Eucalyptus grandis Hill ex-Maiden PITH DISPLACEMENT AND LOG END SPLITTlNG

    Israel Luiz de Lima

    2007-06-01

    Full Text Available The aim of this study was to analyse the influence of thinning and fertilization on some log properties which influence sawn wood yield in a 21 year-old grown Eucalyptus grandis stand. Three selective thinning intensities (37, 50 and 75%, presence or absence of fertilizers on the beginning of the thinning, two diameter classes and two logs taken from two different vertical positions were taken as the study factors. The influence of the factors and their combination on tree growth stresses were indirectly evaluate through log end splitting and pith displacement in relation to its normal central position. Thinning, fertilization, diameter class and log position on the tree height did not have significant effect on pith displacement. The logs from fertilized plots presented higher log end splitting index than others.

  5. The effect of cryogenic cooling and minimum quantity lubrication on end milling of titanium alloy Ti-6Al-4V

    Park, Kyung Hee; Yang, Gi Dong; Lee, Dong Yoon; Kim, Tae Gon; Lee, Seok Woo [Korea Institute of Industrial Technology, Cheonan (Korea, Republic of); Suhaimi, M. A. [Universiti Teknologi Malaysia, Johor Bahru (Malaysia); Kim, Dong Won [Chonbuk National University, Jeonju (Korea, Republic of)

    2015-11-15

    The cooling down of cutting temperature in machining is very important for the improvement of tool life, especially when dealing with work materials that have low thermal conductivity such as titanium alloy. In this study designed to investigate the machining performance of a variety of cooling methods, cryogenic, Minimum quantity lubrication (MQL), and flood cooling are performed on solid end milling of titanium alloy, Ti-6Al-4V. In particular, the effect of internal and external spray methods on cryogenic machining is analyzed with a specially designed liquid nitrogen spraying system by evaluating tool wear and cutting force at cutting conditions. The cutting force is also analyzed for tool breakage detection. As a result, the combination of MQL and internal cryogenic cooling improves tool life by up to 32% compared to conventional cooling methods. The cutting force is also reduced significantly by this combination of cooling and lubrication strategy of side end milling.

  6. The effect of cryogenic cooling and minimum quantity lubrication on end milling of titanium alloy Ti-6Al-4V

    Park, Kyung Hee; Yang, Gi Dong; Lee, Dong Yoon; Kim, Tae Gon; Lee, Seok Woo; Suhaimi, M. A.; Kim, Dong Won

    2015-01-01

    The cooling down of cutting temperature in machining is very important for the improvement of tool life, especially when dealing with work materials that have low thermal conductivity such as titanium alloy. In this study designed to investigate the machining performance of a variety of cooling methods, cryogenic, Minimum quantity lubrication (MQL), and flood cooling are performed on solid end milling of titanium alloy, Ti-6Al-4V. In particular, the effect of internal and external spray methods on cryogenic machining is analyzed with a specially designed liquid nitrogen spraying system by evaluating tool wear and cutting force at cutting conditions. The cutting force is also analyzed for tool breakage detection. As a result, the combination of MQL and internal cryogenic cooling improves tool life by up to 32% compared to conventional cooling methods. The cutting force is also reduced significantly by this combination of cooling and lubrication strategy of side end milling.

  7. Study Abroad and the Boomerang Effect: The End Is Only the Beginning

    Rexeisen, Richard J.

    2013-01-01

    As research on the effectiveness of study abroad programs continues to evolve, the author notes a gradual shift in focus from "Is study abroad effective?" to "What can be done to improve the quality of the study abroad experience?" (e.g., Pederson, 2010; Shaheen, 2004). The author writes that he believes this broadened…

  8. The effect of adherence to statin therapy on cardiovascular mortality: quantification of unmeasured bias using falsification end-points

    Maarten J. Bijlsma

    2016-04-01

    Full Text Available Abstract Background To determine the clinical effectiveness of statins on cardiovascular mortality in practice, observational studies are needed. Control for confounding is essential in any observational study. Falsification end-points may be useful to determine if bias is present after adjustment has taken place. Methods We followed starters on statin therapy in the Netherlands aged 46 to 100 years over the period 1996 to 2012, from initiation of statin therapy until cardiovascular mortality or censoring. Within this group (n = 49,688, up to 16 years of follow-up, we estimated the effect of adherence to statin therapy (0 = completely non-adherent, 1 = fully adherent on ischemic heart diseases and cerebrovascular disease (ICD10-codes I20-I25 and I60-I69 as well as respiratory and endocrine disease mortality (ICD10-codes J00-J99 and E00-E90 as falsification end points, controlling for demographic factors, socio-economic factors, birth cohort, adherence to other cardiovascular medications, and diabetes using time-varying Cox regression models. Results Falsification end-points indicated that a simpler model was less biased than a model with more controls. Adherence to statins appeared to be protective against cardiovascular mortality (HR: 0.70, 95 % CI 0.61 to 0.81. Conclusions Falsification end-points helped detect overadjustment bias or bias due to competing risks, and thereby proved to be a useful technique in such a complex setting.

  9. Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model.

    Laura A Cagle

    Full Text Available Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury.To evaluate the effects of positive end-expiratory pressure and recruitment maneuvers in reducing lung injury in a ventilator-induced lung injury murine model in short- and longer-term ventilation.5-12 week-old female BALB/c mice (n = 85 were anesthetized, placed on mechanical ventilation for either 2 hrs or 4 hrs with either low tidal volume (8 ml/kg or high tidal volume (15 ml/kg with or without positive end-expiratory pressure and recruitment maneuvers.Alteration of the alveolar-capillary barrier was noted at 2 hrs of high tidal volume ventilation. Standardized histology scores, influx of bronchoalveolar lavage albumin, proinflammatory cytokines, and absolute neutrophils were significantly higher in the high-tidal volume ventilation group at 4 hours of ventilation. Application of positive end-expiratory pressure resulted in significantly decreased standardized histology scores and bronchoalveolar absolute neutrophil counts at low- and high-tidal volume ventilation, respectively. Recruitment maneuvers were essential to maintain pulmonary compliance at both 2 and 4 hrs of ventilation.Signs of ventilator-induced lung injury are evident soon after high tidal volume ventilation (as early as 2 hours and lung injury worsens with longer-term ventilation (4 hrs. Application of positive end-expiratory pressure and recruitment maneuvers are protective against worsening VILI across all time points. Dynamic compliance can be used guide

  10. Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model

    Franzi, Lisa M.; Linderholm, Angela L.; Last, Jerold A.; Adams, Jason Y.; Harper, Richart W.

    2017-01-01

    Background Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury. Objectives To evaluate the effects of positive end-expiratory pressure and recruitment maneuvers in reducing lung injury in a ventilator-induced lung injury murine model in short- and longer-term ventilation. Methods 5–12 week-old female BALB/c mice (n = 85) were anesthetized, placed on mechanical ventilation for either 2 hrs or 4 hrs with either low tidal volume (8 ml/kg) or high tidal volume (15 ml/kg) with or without positive end-expiratory pressure and recruitment maneuvers. Results Alteration of the alveolar-capillary barrier was noted at 2 hrs of high tidal volume ventilation. Standardized histology scores, influx of bronchoalveolar lavage albumin, proinflammatory cytokines, and absolute neutrophils were significantly higher in the high-tidal volume ventilation group at 4 hours of ventilation. Application of positive end-expiratory pressure resulted in significantly decreased standardized histology scores and bronchoalveolar absolute neutrophil counts at low- and high-tidal volume ventilation, respectively. Recruitment maneuvers were essential to maintain pulmonary compliance at both 2 and 4 hrs of ventilation. Conclusions Signs of ventilator-induced lung injury are evident soon after high tidal volume ventilation (as early as 2 hours) and lung injury worsens with longer-term ventilation (4 hrs). Application of positive end-expiratory pressure and recruitment maneuvers are protective against worsening VILI across all time points

  11. Effects of positive end-expiratory pressure and recruitment maneuvers in a ventilator-induced injury mouse model.

    Cagle, Laura A; Franzi, Lisa M; Linderholm, Angela L; Last, Jerold A; Adams, Jason Y; Harper, Richart W; Kenyon, Nicholas J

    2017-01-01

    Positive-pressure mechanical ventilation is an essential therapeutic intervention, yet it causes the clinical syndrome known as ventilator-induced lung injury. Various lung protective mechanical ventilation strategies have attempted to reduce or prevent ventilator-induced lung injury but few modalities have proven effective. A model that isolates the contribution of mechanical ventilation on the development of acute lung injury is needed to better understand biologic mechanisms that lead to ventilator-induced lung injury. To evaluate the effects of positive end-expiratory pressure and recruitment maneuvers in reducing lung injury in a ventilator-induced lung injury murine model in short- and longer-term ventilation. 5-12 week-old female BALB/c mice (n = 85) were anesthetized, placed on mechanical ventilation for either 2 hrs or 4 hrs with either low tidal volume (8 ml/kg) or high tidal volume (15 ml/kg) with or without positive end-expiratory pressure and recruitment maneuvers. Alteration of the alveolar-capillary barrier was noted at 2 hrs of high tidal volume ventilation. Standardized histology scores, influx of bronchoalveolar lavage albumin, proinflammatory cytokines, and absolute neutrophils were significantly higher in the high-tidal volume ventilation group at 4 hours of ventilation. Application of positive end-expiratory pressure resulted in significantly decreased standardized histology scores and bronchoalveolar absolute neutrophil counts at low- and high-tidal volume ventilation, respectively. Recruitment maneuvers were essential to maintain pulmonary compliance at both 2 and 4 hrs of ventilation. Signs of ventilator-induced lung injury are evident soon after high tidal volume ventilation (as early as 2 hours) and lung injury worsens with longer-term ventilation (4 hrs). Application of positive end-expiratory pressure and recruitment maneuvers are protective against worsening VILI across all time points. Dynamic compliance can be used guide the frequency

  12. To end life or to save life: ageism moderates the effect of message framing on attitudes towards older adults' suicide.

    Gamliel, Eyal; Levi-Belz, Yossi

    2016-08-01

    Global suicide rates among older adults are very high. Public attitudes towards older adults' suicide may affect older adults upon their contemplating such an act. Previous research has demonstrated that message framing affects persons' judgments and decision making. Thus, message framing may have particular significance in the context of attitudes towards end-of-life phenomena, such as physician-aided suicide. This study examined the possible role of ageism in moderating the effect of message framing on attitudes towards older adults' suicide. Two studies examined the association between ageism and attitudes towards older adults' suicide. Study 1 assessed both variables by self-administered questionnaires; Study 2 further examined these variables, incorporating participants' responses to a suicide-related vignette, and evaluating the possible effect of message framing, using a between-participants design. High-ageism participants expressed greater acceptance for older adults' suicide, whereas low-ageism participants expressed a less permissive approach to it (Study 1). In addition, ageism moderated the effect of message framing on attitudes towards older adults' suicide: High-ageism participants revealed a more permissive attitude towards older adults' suicide when the issue was presented in positive terms of not prolonging life, relative to a negative presentation of ending life; a similar effect was not found for low-ageism participants (Study 2). The moderating effect of ageism on attitudes towards older adults' suicide has both theoretical and practical implications. We discuss these implications with respect to suicide prevention among older adults, and suggest future research.

  13. Effectiveness of group cognitive behavioral therapy with mindfulness in end-stage renal disease hemodialysis patients

    Bo Kyung Sohn

    2018-03-01

    Full Text Available Background : Many patients with end-stage renal disease (ESRD undergoing hemodialysis (HD experience depression. Depression influences patient quality of life (QOL, dialysis compliance, and medical comorbidity. We developed and applied a group cognitive behavioral therapy (CBT program including mindfulness meditation for ESRD patients undergoing HD, and measured changes in QOL, mood, anxiety, perceived stress, and biochemical markers. Methods : We conducted group CBT over a 12-week period with seven ESRD patients undergoing HD and suffering from depression. QOL, mood, anxiety, and perceived stress were measured at baseline and at weeks 8 and 12 using the World Health Organization Quality of Life scale, abbreviated version (WHOQOL-BREF, the Beck Depression Inventory II (BDI-II, the Hamilton Rating Scale for Depression (HAM-D, the Beck Anxiety Inventory (BAI, and the Perceived Stress Scale (PSS. Biochemical markers were measured at baseline and after 12 weeks. The Temperament and Character Inventory was performed to assess patient characteristics before starting group CBT. Results : The seven patients showed significant improvement in QOL, mood, anxiety, and perceived stress after 12 weeks of group CBT. WHOQOL-BREF and the self-rating scales, BDI-II and BAI, showed continuous improvement across the 12-week period. HAM-D scores showed significant improvement by week 8; PSS showed significant improvement after week 8. Serum creatinine levels also improved significantly following the 12 week period. Conclusion : In this pilot study, a CBT program which included mindfulness meditation enhanced overall mental health and biochemical marker levels in ESRD patients undergoing HD.

  14. Heat transfer system safety: Comparing the effectiveness of batch venting and a light-ends removal kit (LERK

    Christopher Ian Wright

    2014-11-01

    Full Text Available Heat transfer fluids (HTF should be analysed at least once per year to determine the extent of thermal degradation. Under normal operating conditions, mineral-based HTFs will thermally degrade and the bonds between hydrocarbons break to form shorter-chain hydrocarbons known as “light-ends”. These light-ends accumulate in a HTF system and present a future potential fire risk. Light-ends can be removed from a HTF system via a batch vent or installation of a temporary or permanently installed light-ends removal kit (LERK. Data was collected prior to and following batch venting or installation of a LERK. The main study parameter was closed flash temperature as open flash temperature and fire point did not change considerably. Analysis showed that both methods increased closed flash temperature in excess of 130 °C three months after the intervention, so both methods were deemed effective. Data showed that the percentage change achieved with the LERK, compared to batch venting, was 2-fold higher at three months and 10-fold higher at 6 months. The duration of effect was longer with the LERK with closed flash temperature being stable and consistently above 130 °C for 50 months after being permanently installed. This case highlights the effectiveness of a permanently fitted LERK which is effective for the longer-term control of closed flash temperature. However, mobile LERKs could be an option for manufacturers looking to manage closed flash temperature on a shorter-term basis or as an alternative to batch venting.

  15. Effect of feedstock end boiling point on product sulphur during ultra deep diesel hydrodesulphurization

    Stratiev, D.; Ivanov, A.; Jelyaskova, M. [Lukoil Neftochim Bourgas AD, Bourgas (Bulgaria)

    2004-12-01

    An investigation was carried out to test the feasibility of producing 50 and 10 ppm sulphur diesel in a conventional hydrotreating unit operating at low pressure conditions by varying the feedstock end boiling point. Middle distillate fractions distilled from a mixture of Ural crude oil, reduced crude, vacuum gas oil, naphtha and low sulphur crude oils with 95% vol. points of 274, 359, 343, 333, and 322 C (ASTM D-86 method) and sulphur contents of 0.36, 0.63, 0.99, 0.57, and 0.47%, respectively, were hydrotreated using the Akzo Nobel Stars family Co-Mo KF-757 catalyst in a trickle bed pilot plant at following conditions: reactor inlet temperature range of 320-360 C; liquid hourly space velocity (LHSV) range of 1-2 h{sup -1}; total reactor pressure of 3.5 MPa; treating gas: feedstock ratio of 250 Nm{sup 3}/m{sup 3}. It was found that the determinant factor for the attainment of ultra low sulphur levels during middle distillate hydrodesulphurization was not the total sulphur content in the feed but the content of the material boiling above 340 C (according to TBP). For all LHSVs and reactor inlet temperatures studied the product sulphur dependence on the feed 340 C+ fraction content was approximated by second order power law. The specification of 50 ppm sulphur was achieved with all studied feedstocks. However the 10ppm sulphur limit could be met only by feedstocks with 95% vol. points below 333 C, which is accompanied by about 10% reduction of the diesel potential. The hydrotreatment tests on a blend 80% straight run gas oil (ASTM D-86 95% vol. of 274 C)/20%FCC LCO (ASTM D-86 95% vol. of 284 C) showed product sulphur levels which were not higher than those obtained by hydrotreatment of the straight run gas oil, indicating that undercutting the FCC LCO gives the refiner the opportunity to increase the potential for the production of 10 ppm sulphur diesel at the conditions of the conventional hydrotreating unit operating at low pressure. The product cetane index was

  16. Effect of udder massage at the end of milking on residual milk and mastitis occurrence in dairy cows.

    Marcela Cristina Agustini Carneiro da Silveira

    2009-03-01

    Full Text Available Residual milk (RM after milking is an important factor that can predispose cows to mastitis. In this study, the hypothesis that udder massage at the end of milking may reduce RM and the incidence of mastitis was tested in two experiments. Experiment 1 was conducted on an experimental farm with ten lactating cows (6,200kg/lactation and experiment 2 was carried out on a commercial farm with 52 lactating cows (4,480kg/lactation. In both experiments the cows were paired by parity, stage of lactation and productivity, and they were randomly assigned to one of the treatments: massage or no massage of the udder at the end of milking, in two periods in a crossover design. The individual milk production of each cow was measured. Residual milk was collected and measured 2min after an oxitocin application. California Mastitis Test was used to detect the occurrence (experiment 1 p > 0.41, n = 10 and experiment 2 p > 0.46, n = 12, on RM (experiment 1, 1.78 ± 0.45kg, n = 10; experiment 2, 2.42 ± 0.32kg, n = 12, or on mastitis incidence (experiment 2, chi-square; DF = 1; p > 0.68, n = 26. We conclude that udder massage at the end of milking has no effect on RM and does not affect mastitis incidence, at least under the conditions used in these experiments.

  17. Effect of Thai banana (Musa AA group) in reducing accumulation of oxidation end products in UVB-irradiated mouse skin.

    Leerach, Nontaphat; Yakaew, Swanya; Phimnuan, Preeyawass; Soimee, Wichuda; Nakyai, Wongnapa; Luangbudnark, Witoo; Viyoch, Jarupa

    2017-03-01

    Chronic UVB exposure causes skin disorders and cancer through DNA strand breaks and oxidation of numerous functional groups of proteins and lipids in the skin. In this study, we investigated the effects of Thai banana (Musa AA group, "Khai," and Musa ABB group, "Namwa") on the prevention of UVB-induced skin damage when fed to male ICR mice. Mice were orally fed banana (Khai or Namwa) fruit pulps at dose of 1mg/g body weight/day for 12weeks. The shaved backs of the mice were irradiated with UVB for 12weeks. The intensity dose of UVB-exposure was increased from 54mJ/cm 2 /exposure at week 1 to 126mJ/cm 2 /exposure at week 12. A significant increase in skin thickness, lipid peroxidation, protein oxidation end products, and expression of MMP-1 was observed in UVB-irradiated mouse skin. A reduction in the accumulation of oxidation end products was found in the skin of UVB-irradiated mice receiving Khai. This occurred in conjunction with a reduction in MMP-1 expression, inhibition of epidermal thickening, and induction of γ-GCS expression. The dietary intake of Khai prevented skin damage from chronic UVB exposure by increased γ-GCS expression and reduced oxidation end products included carbonyls, malondialdehyde and 4-hydroxynonenal. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Total dose effects on ATLAS-SCT front-end electronics

    Ullán, M; Dubbs, T; Grillo, A A; Spencer, E; Seiden, A; Spieler, H; Gilchriese, M G D; Lozano, M

    2002-01-01

    Low dose rate effects (LDRE) in bipolar technologies complicate the hardness assurance testing for high energy physics applications. The damage produced in the ICs in the real experiment can be underestimated if fast irradiations are carried out, while experiments done at the real dose rate are usually unpractical due to the still high total doses involved. In this work the sensitivity to LDRE of two bipolar technologies proposed for the ATLAS-SCT experiment at CERN is evaluated, finding one of them free of those effects. (12 refs).

  19. Influence of End-Effects on Static Torque Performance of Misaligned Cylindrical Permanent Magnet Couplings

    Högberg, Stig; Hansen, Hilary; Jensen, Bogi Bech

    2014-01-01

    Permanent magnet couplings are widely used in applications requiring torque to be transmitted through an air- gap. The aim of this study is to observe and explain the effect of radial and axial misalignment in a 12-pole, cylindrical permanent magnet coupling. Pull-out torque was measured for two...

  20. Effect of End-Tidal Carbon Dioxide Measurement on Resuscitation Efficiency and Termination of Resuscitation

    Faruk OZTURK

    2014-03-01

    Conclusions: ETCO2 levels predicted survival as well as the effectiveness of CPR for patients who received CPR and were monitored by capnometry in the emergency department. As a result, we believe that it would be suitable to use capnometry in all units where the CPR is performed.

  1. Philips Electronics synchronizes its supply chain to end the bullwhip effect

    Kok, de A.G.; Janssen, F.B.S.L.P.; van Doremalen, J.B.M.; Wachem, van E.; Clerkx, M.J.R.; Peeters, W.

    2005-01-01

    Demand variability increases as one moves up a supply chain. The demand for finished products is less variable than for subassemblies, which is less variable than for individual components. This phenomenon is known as the bullwhip or Forrester effect. It increases inventory unnecessarily and makes

  2. Pulmonary hypertension in end-stage pulmonary sarcoidosis: therapeutic effect of sildenafil?

    Milman, N.; Burton, C.M.; Iversen, M.

    2008-01-01

    BACKGROUND: The objectives of this study were to assess the frequency and severity of pulmonary hypertension (PH) and the effect of sildenafil treatment in patients with recalcitrant pulmonary sarcoidosis. METHODS: This investigation was a single-center, retrospective study of all patients (n = 25...

  3. On vortex-airfoil interaction noise including span-end effects, with application to open-rotor aeroacoustics

    Roger, Michel; Schram, Christophe; Moreau, Stéphane

    2014-01-01

    A linear analytical model is developed for the chopping of a cylindrical vortex by a flat-plate airfoil, with or without a span-end effect. The major interest is the contribution of the tip-vortex produced by an upstream rotating blade in the rotor-rotor interaction noise mechanism of counter-rotating open rotors. Therefore the interaction is primarily addressed in an annular strip of limited spanwise extent bounding the impinged blade segment, and the unwrapped strip is described in Cartesian coordinates. The study also addresses the interaction of a propeller wake with a downstream wing or empennage. Cylindrical vortices are considered, for which the velocity field is expanded in two-dimensional gusts in the reference frame of the airfoil. For each gust the response of the airfoil is derived, first ignoring the effect of the span end, assimilating the airfoil to a rigid flat plate, with or without sweep. The corresponding unsteady lift acts as a distribution of acoustic dipoles, and the radiated sound is obtained from a radiation integral over the actual extent of the airfoil. In the case of tip-vortex interaction noise in CRORs the acoustic signature is determined for vortex trajectories passing beyond, exactly at and below the tip radius of the impinged blade segment, in a reference frame attached to the segment. In a second step the same problem is readdressed accounting for the effect of span end on the aerodynamic response of a blade tip. This is achieved through a composite two-directional Schwarzschild's technique. The modifications of the distributed unsteady lift and of the radiated sound are discussed. The chained source and radiation models provide physical insight into the mechanism of vortex chopping by a blade tip in free field. They allow assessing the acoustic benefit of clipping the rear rotor in a counter-rotating open-rotor architecture.

  4. End Effects in Rotational Viscometry I. No-Slip Shear-Thinning Samples in the Z40 DIN Sensor.

    Wein, Ondřej; Večeř, Marek; Havlica, Jaromír

    2007-01-01

    Roč. 46, 5 (2007) , s. 765-772 ISSN 0035-4511. [Annual Rheology Conference AERC 2006 /3./. Crete, 27.04.2006-29.04.2006] R&D Projects: GA ČR(CZ) GA104/04/0826; GA ČR GP104/06/P287; GA ČR GP104/05/P554 Institutional research plan: CEZ:AV0Z40720504 Keywords : rotational couette flow * shear-thinning fluids * end effects Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 1.110, year: 2007

  5. Neoclassical resonant-plateau transport calculation in an effectively axisymmetrized tandem mirror with finite end plate resistance

    Katanuma, I.; Kiwamoto, Y.; Adachi, S.; Inutake, M.; Ishii, K.; Yatsu, K.; Sawada, K.; Miyoshi, S.

    1987-05-01

    Calculations are made for neoclassical resonant-plateau transports in the geometry of the effectively axisymmetrized tandem mirror GAMMA 10 magnetic field, which has minimum B inbord anchors inside the axisymmetric plug/barrier mirror cells. Azimuthal drifts at the local non-axisymmetric regions are included. The radial potential profile is determined by solving selfconsistently the charge neutrality equation. A finite resistance connecting end plate to machine ground provides appropriate boundary conditions on the radial electrostatic potential distribution so that it can be determined uniquely. The calculation is consistent with experimental results of GAMMA 10. (author)

  6. The Effect of Renal Transplantation on Respiratory Muscle Strength in Patients with End Stage Renal Disease

    Tavana, Sasan; Mirzaei, Samaneh

    2016-01-01

    Background: There is evidence of musculoskeletal and respiratory involvement in patients with chronic kidney disease (CKD). This is attributed to protein calorie imbalance that is caused by the disease process, and hemodialysis and is generally referred to as uremic myopathy. This results in calcification of respiratory muscles such as diaphragm and intercostal muscles. There are limited data about respiratory muscle strength in patients with CKD. We intended to evaluate the effect of kidney ...

  7. End-of-life decisions and the reinvented Rule of Double Effect: a critical analysis.

    Lindblad, Anna; Lynöe, Niels; Juth, Niklas

    2014-09-01

    The Rule of Double Effect (RDE) holds that it may be permissible to harm an individual while acting for the sake of a proportionate good, given that the harm is not an intended means to the good but merely a foreseen side-effect. Although frequently used in medical ethical reasoning, the rule has been repeatedly questioned in the past few decades. However, Daniel Sulmasy, a proponent who has done a lot of work lately defending the RDE, has recently presented a reformulated and more detailed version of the rule. Thanks to its greater precision, this reinvented RDE avoids several problems thought to plague the traditional RDE. Although an improvement compared with the traditional version, we argue that Sulmasy's reinvented RDE will not stand closer scrutiny. Not only has the range of proper applicability narrowed significantly, but, more importantly, Sulmasy fails to establish that there is a morally relevant distinction between intended and foreseen effects. In particular, he fails to establish that there is any distinction that can account for the alleged moral difference between sedation therapy and euthanasia. © 2012 John Wiley & Sons Ltd.

  8. Experimental investigation of the influence of natural convection and end-effects on Rayleigh streaming in a thermoacoustic engine.

    Ramadan, Islam A; Bailliet, Hélène; Valière, Jean-Christophe

    2018-01-01

    The influence of both the natural convection and end-effects on Rayleigh streaming pattern in a simple standing-wave thermoacoustic engine is investigated experimentally at different acoustic levels. The axial mean velocity inside the engine is measured using both Laser Doppler Velocimetry and Particle Image Velocimetry. The mean flow patterns are categorized in three different regions referred to as "cold streaming" region, "hot streaming" region, and "end-effects" region. In the cold streaming region, the dominant phenomenon is Rayleigh streaming and the mean velocity measurements correspond well with the theoretical expectations of Rayleigh streaming at low acoustic levels. At higher acoustic levels, the measurements deviate from the theoretical expectations which complies with the literature. In the hot streaming region, temperature measurements reveal that the non-uniformity of the resonator wall temperature is the origin of natural convection flow. Velocity measurements show that natural convection flow superimposes on the Rayleigh streaming flow so that the measured mean velocity deviates from the theoretical expectations of Rayleigh streaming. In the last region, the measured mean velocity is very different from Rayleigh streaming due to the combined effects of both the flow disturbances generated near the extremity of the stack and the natural convection flow.

  9. Effects of hemodialysis on iodine-131 biokinetics in thyroid carcinoma patients with end-stage chronic renal failure.

    Yeyin, Nami; Cavdar, Iffet; Uslu, Lebriz; Abuqbeitah, Mohammad; Demir, Mustafa

    2016-03-01

    Radioiodine therapy could be challenging in chronic renal failure patients requiring hemodialysis. The aim of this study was to establish the effects of hemodialysis on elimination of radioiodine from the body in thyroid carcinoma patients with end-stage chronic renal failure and to determine its effects on environmental radiation dose. Three end-stage chronic renal failure patients (four cases) diagnosed with differentiated thyroid carcinoma requiring radioiodine therapy were included in our study. Each patient was given 50-75 mCi (1850-2775 MBq) iodine-131 with 50% dose reduction. Dose rate measurement was performed at the 2nd, 24th, and 48th hour (immediately before and after hemodialysis) after radioiodine administration. The Geiger-Müller probe was held at 1 m distance at the level of the midpoint of the thorax for the dose rate measurement. The effective half-life of iodine-131 for three patients was found to be 44 h. In conclusion, the amount of radioiodine excreted per hemodialysis session was calculated to be 51.25%.

  10. Effects of end-stage renal disease and dialysis modalities on blood ammonia level.

    Vaziri, Nosratola D; Khazaeli, Mahyar; Nunes, Ane C F; Harley, Kevin T; Said, Hyder; Alipour, Omeed; Lau, Wei Ling; Pahl, Madeleine V

    2017-07-01

    Uremia results in a characteristic breath odor (uremic fetor) which is largely due to its high ammonia content. Earlier studies have shown a strong correlation between breath ammonia and blood urea levels and a 10-fold reduction in breath ammonia after hemodialysis in patients with chronic kidney disease. Potential sources of breath ammonia include: (i) local ammonia production from hydrolysis of urea in the oropharyngeal and respiratory tracts by bacterial flora, and (ii) release of circulating blood ammonia by the lungs. While the effects of uremia and hemodialysis on breath ammonia are well known their effects on blood ammonia are unknown and were explored here. Blood samples were obtained from 23 hemodialysis patients (immediately before and after dialysis), 14 peritoneal dialysis patients, and 10 healthy controls. Blood levels of ammonia, creatinine, urea, and electrolytes were measured. No significant difference was found in baseline blood ammonia between hemodialysis, peritoneal dialysis and control groups. Hemodialysis procedure led to a significant reduction in urea concentration (P ammonia level in 10 of the 23 patients studied. Change in blood ammonia pre- and post-hemodialysis correlated with change in serum bicarbonate levels (r = 0.61, P ammonia levels after dialysis, there was a strong correlation with drop in mean arterial pressure (r = 0.88, P ammonia compared to the patients who manifested a fall in blood ammonia (124 ± 8 vs. 136 ± 6 mmHg respectively, P = 0.27). Fall in blood urea following hemodialysis in ESRD patients was paradoxically accompanied by a modest rise in blood ammonia levels in 43% of the patients studied, contrasting prior reported effects of hemodialysis on breath ammonia. In this subgroup of patients, changes in blood ammonia during hemodialysis correlated with rise in blood bicarbonate and fall in mean arterial blood pressure. © 2016 International Society for Hemodialysis.

  11. Practical Investigation of End Effect Losses in a Motor Integrated Permanent Magnet Gear

    Frandsen, Tommy Vestergaard; Rasmussen, Peter Omand

    2015-01-01

    to reduce 3D eddy currents in the machine. Material is removed and new parts are made in a non-conducting material. After the modifications of the prototype, the rotational losses have been measured and compared to the earlier measurements and the 2D based calculated losses. The rotational losses have been......This paper presents a practical investigation of the eddy current losses caused by 3D effects in a Motor Integrated Permanent Magnet Gear (MIPMG). Two prototypes of a MIPMG have been designed and build to be used as traction units for an electric vehicle. The measured efficiency of the prototype...

  12. Effect of food additives on hyperphosphatemia among patients with end-stage renal disease: a randomized controlled trial.

    Sullivan, Catherine; Sayre, Srilekha S; Leon, Janeen B; Machekano, Rhoderick; Love, Thomas E; Porter, David; Marbury, Marquisha; Sehgal, Ashwini R

    2009-02-11

    High dietary phosphorus intake has deleterious consequences for renal patients and is possibly harmful for the general public as well. To prevent hyperphosphatemia, patients with end-stage renal disease limit their intake of foods that are naturally high in phosphorus. However, phosphorus-containing additives are increasingly being added to processed and fast foods. The effect of such additives on serum phosphorus levels is unclear. To determine the effect of limiting the intake of phosphorus-containing food additives on serum phosphorus levels among patients with end-stage renal disease. Cluster randomized controlled trial at 14 long-term hemodialysis facilities in northeast Ohio. Two hundred seventy-nine patients with elevated baseline serum phosphorus levels (>5.5 mg/dL) were recruited between May and October 2007. Two shifts at each of 12 large facilities and 1 shift at each of 2 small facilities were randomly assigned to an intervention or control group. Intervention participants (n=145) received education on avoiding foods with phosphorus additives when purchasing groceries or visiting fast food restaurants. Control participants (n=134) continued to receive usual care. Change in serum phosphorus level after 3 months. At baseline, there was no significant difference in serum phosphorus levels between the 2 groups. After 3 months, the decline in serum phosphorus levels was 0.6 mg/dL larger among intervention vs control participants (95% confidence interval, -1.0 to -0.1 mg/dL). Intervention participants also had statistically significant increases in reading ingredient lists (Pfood knowledge scores (P = .13). Educating end-stage renal disease patients to avoid phosphorus-containing food additives resulted in modest improvements in hyperphosphatemia. clinicaltrials.gov Identifier: NCT00583570.

  13. Effects of advanced glycation end-product inhibition and cross-link breakage in diabetic rats

    Oturai, P S; Christensen, M; Rolin, B

    2000-01-01

    ), and a breaker of already formed AGE cross-links, N-phenacylthiazolium bromide (PTB), were investigated in streptozotocin-diabetic female Wistar rats. Diabetes for 24 weeks resulted in decreased tail collagen pepsin solubility, reflecting the formation of AGE cross-linking. Collagen solubility was significantly...... ameliorated by treatment with NNC39-0028, whereas PTB had no effect. Increased urinary albumin excretion (UAE) in diabetic rats was observed in serial measurements throughout the study period, and was not reduced by any treatment. Vascular dysfunction in the eye, measured as increased clearance of 125I......-albumin, was induced by diabetes. NNC39-0028 did not affect this abnormality. This study demonstrated a pharmacological inhibition of collagen solubility alterations in diabetic rats without affecting diabetes-induced pathophysiology such as the increase in UAE or albumin clearance. Treatment with PTB, a specific...

  14. Alterations of erythrocyte rheology and cellular susceptibility in end stage renal disease: Effects of peritoneal dialysis.

    Nesrin Zeynep Ertan

    Full Text Available In this study, we investigated the effects of peritoneal dialysis on hemorheological and hematological parameters and their relations with oxidant and antioxidant status of uremic patients. Hemorheological parameters (erythrocyte deformability, erythrocyte aggregation, osmotic deformability, blood and plasma viscosity were measured in patients with renal insufficiency undergoing peritoneal dialysis (PD and volunteers. Erythrocyte deformability, osmotic deformability and aggregation in both autologous plasma and 3% dextran 70 were measured by laser diffraction ektacytometry. Enzyme activities of glutathione peroxidase, superoxide dismutase and catalase were studied in erythrocytes; lipid peroxidation was studied by measuring the amount of malondialdehyde in both erythrocytes and plasma samples. Blood viscosity at native hematocrit was significantly lower in PD patients at all measured shear rates compared to controls, but it was high in PD patients at corrected (45% hematocrit. Erythrocyte deformability did not show any difference between the two groups. Osmotic deformability was significantly lower in PD patients compared to controls. Aggregation index values were significantly high in PD patients in plasma Catalase and glutathione peroxidase activities in erythrocytes were decreased in PD patients whereas superoxide dismutase activity was increased compared to controls. Malondialdehyde was significantly increased in erythrocytes and plasma samples of PD patients which also shows correlations with aggregation parameters. It has been concluded that erythrocytes in PD patients are more prone to aggregation and this tendency could be influenced by lipid peroxidation activity in patient's plasma. These results imply that uremic conditions, loss of plasma proteins and an increased risk of oxidative stress because of decreasing levels of antioxidant enzymes affect erythrocyte rheology during peritoneal dialysis. This level of distortion may have

  15. Effect of Positive End-Expiratory Pressure on Central Venous Pressure in Patients under Mechanical Ventilation.

    Shojaee, Majid; Sabzghabaei, Anita; Alimohammadi, Hossein; Derakhshanfar, Hojjat; Amini, Afshin; Esmailzadeh, Bahareh

    2017-01-01

    Finding the probable governing pattern of PEEP and CVP changes is an area of interest for in-charge physicians and researchers. Therefore, the present study was designed with the aim of evaluating the relationship between the mentioned pressures. In this quasi-experimental study, patients under mechanical ventilation were evaluated with the aim of assessing the effect of PEEP change on CVP. Non-trauma patients, over 18 years of age, who were under mechanical ventilation and had stable hemodynamics, with inserted CV line were entered. After gathering demographic data, patients underwent 0, 5, and 10 cmH 2 O PEEPs and the respective CVPs of the mentioned points were recorded. The relationship of CVP and PEEP in different cut points were measured using SPSS 21.0 statistical software. 60 patients with the mean age of 73.95 ± 11.58 years were evaluated (68.3% male). The most frequent cause of ICU admission was sepsis with 45.0%. 5 cmH 2 O increase in PEEP led to 2.47 ± 1.53 mean difference in CVP level. If the PEEP baseline is 0 at the time of 5 cmH 2 O increase, it leads to a higher raise in CVP compared to when the baseline is 5 cmH 2 O (2.47 ± 1.53 vs. 1.57 ± 1.07; p = 0.039). The relationship between CVP and 5 cmH 2 O (p = 0.279), and 10 cmH 2 O (p = 0.292) PEEP changes were not dependent on the baseline level of CVP. The findings of this study revealed the direct relationship between PEEP and CVP. Approximately, a 5 cmH 2 O increase in PEEP will be associated with about 2.5 cmH 2 O raise in CVP. When applying a 5 cmH 2 O PEEP increase, if the baseline PEEP is 0, it leads to a significantly higher raise in CVP compared to when it is 5 cmH 2 O (2.5 vs. 1.6). It seems that sex, history of cardiac failure, baseline CVP level, and hypertension do not have a significant effect in this regard.

  16. Effect of Positive End-Expiratory Pressure on Central Venous Pressure in Patients under Mechanical Ventilation

    Majid Shojaee

    2016-12-01

    Full Text Available Introduction: Finding the probable governing pattern of PEEP and CVP changes is an area of interest for in-charge physicians and researchers. Therefore, the present study was designed with the aim of evaluating the relationship between the mentioned pressures. Methods: In this quasi-experimental study, patients under mechanical ventilation were evaluated with the aim of assessing the effect of PEEP change on CVP. Non-trauma patients, over 18 years of age, who were under mechanical ventilation and had stable hemodynamics, with inserted CV line were entered. After gathering demographic data, patients underwent 0, 5, and 10 cmH2O PEEPs and the respective CVPs of the mentioned points were recorded. The relationship of CVP and PEEP in different cut points were measured using SPSS 21.0 statistical software. Results: 60 patients with the mean age of 73.95 ± 11.58 years were evaluated (68.3% male. The most frequent cause of ICU admission was sepsis with 45.0%. 5 cmH2O increase in PEEP led to 2.47 ± 1.53 mean difference in CVP level. If the PEEP baseline is 0 at the time of 5 cmH2O increase, it leads to a higher raise in CVP compared to when the baseline is 5 cmH2O (2.47 ± 1.53 vs. 1.57 ± 1.07; p = 0.039. The relationship between CVP and 5 cmH2O (p = 0.279, and 10 cmH2O (p = 0.292 PEEP changes were not dependent on the baseline level of CVP. Conclusion: The findings of this study revealed the direct relationship between PEEP and CVP. Approximately, a 5 cmH2O increase in PEEP will be associated with about 2.5 cmH2O raise in CVP. When applying a 5 cmH2O PEEP increase, if the baseline PEEP is 0, it leads to a significantly higher raise in CVP compared to when it is 5 cmH2O (2.5 vs. 1.6. It seems that sex, history of cardiac failure, baseline CVP level, and hypertension do not have a significant effect in this regard.

  17. Effect of a home-based end-of-life nursing service on hospital use at the end of life and place of death: a study using administrative data and matched controls.

    Chitnis, X A; Georghiou, T; Steventon, A; Bardsley, M J

    2013-12-01

    To assess the effect of routinely delivered home-based end-of-life care on hospital use at the end of life and place of death. Retrospective analysis using matched controls and administrative data. Community-based care in England. 29,538 people aged over 18 who received Marie Curie nursing support compared with 29,538 controls individually matched on variables including: age, socioeconomic deprivation, prior hospital use, number of chronic conditions and prior diagnostic history. Home-based end-of-life nursing care delivered by the Marie Curie Nursing Service (MCNS), compared with end-of-life care available to those who did not receive MCNS care. Proportion of people who died at home; numbers of emergency and elective inpatient admissions, outpatient attendances and attendances at emergency departments in the period until death; and notional costs of hospital care. Intervention patients were significantly more likely to die at home and less likely to die in hospital than matched controls (unadjusted OR 6.16, 95% CI 5.94 to 6.38, pnursing for longer. Home-based end-of-life care offers the potential to reduce demand for acute hospital care and increase the number of people able to die at home.

  18. The Effects of Ilkhanid's Marine Policy on International Trade at the end of Middle Ages

    ahmad fazlinejad

    2016-03-01

    Full Text Available The access to seas and high seas was one of the significant concerns of Iranian government's foreign policy during history. The geographical position of Iran- located two seas in north and south of it- provided a golden opportunity for Iranian government to have the influential role in international trade and protection of national security. Ilkhanid government settled in a land which lying from Oxus in east to Euphrates in west and from southern coasts of Black sea in north to Persian Gulf in south. By employing marine policy in commercial relations, Ilkhanid government played a substantial role in international trade during middle Ages. The factors of Ilkhanid's marine trade were based on dominance over Caucasus and election of Azarbayejan district as capital, sovereignty over Mesopotamia in order to control Red Sea and Indian Ocean and also influence over Anatolia and Asia Minor in order to control the southern ports of Black Sea. This marine policy had some considerable consequences such as control of commercial routes between East and West, Competition with Golden Horde and Mamalik government, relations with commercial government of Mediterranean districts and inauguration of commercial road of Tabriz to Hormoz and from Hormoz to Indian Ocean and China Sea which was regarded to be a significant event in international trade history. This research investigates the role of Ilkhanid's marine policy in changes of marine trades between East and West. The outcome of such research demonstrates that Ilkhanid government not only resisted against local marine and its rivals but also had the effective role in connection of marine trade districts of Mediterranean, Black Sea and Indian Ocean.

  19. Differential Effects of Intraoperative Positive End-expiratory Pressure (PEEP) on Respiratory Outcome in Major Abdominal Surgery Versus Craniotomy

    de Jong, Myrthe A C; Ladha, Karim S; Melo, Marcos F Vidal

    2015-01-01

    OBJECTIVES: In this study, we examined whether (1) positive end-expiratory pressure (PEEP) has a protective effect on the risk of major postoperative respiratory complications in a cohort of patients undergoing major abdominal surgeries and craniotomies, and (2) the effect of PEEP is differed......: Within the entire study population (major abdominal surgeries and craniotomies), we found an association between application of PEEP ≥5 cmH2O and a decreased risk of postoperative respiratory complications compared with PEEP 5 cmH2O was associated with a significant lower...... undergoing major abdominal surgery. Our data suggest that default mechanical ventilator settings should include PEEP of 5-10 cmH2O during major abdominal surgery....

  20. Effect of advanced glycosylation end products (AGEs) on proliferation of human bone marrow mesenchymal stem cells (MSCs) in vitro.

    Lu, Yi-Qun; Lu, Yan; Li, Hui-Juan; Cheng, Xing-Bo

    2012-10-01

    This study aims to explore the effect of advanced glycosylation end products (AGEs) on proliferation of human bone marrow mesenchymal stem cells in vitro and the underlying mechanism. Bone marrow cell proliferation was determined by WST-8 assay using Cell Counting Kit-8 under the intervention of AGEs. In addition, the content of maldondialdehyde (MDA) and the activity of superoxide dismutase (SOD) were also measured. The proliferation activity of mesenchymal stem cells (MSCs) was significantly inhibited when AGEs were added to culture medium, and this effect was dose-dependent and time-dependent. As the concentration of AGEs-bovine serum albumin increased, the content of intracellular MDA was significantly increased, but the activity of SOD in cell homogenates was significantly suppressed, which also showed a dose-dependent manner. AGEs could significantly inhibit the proliferation of MSCs in vitro by improving the oxidative stress in MSCs and breaking the homeostasis of intracellular environment.

  1. Effect of dignity therapy on end-of-life psychological distress in terminally ill Portuguese patients: A randomized controlled trial.

    Julião, Miguel; Oliveira, Fátima; Nunes, Baltazar; Carneiro, António Vaz; Barbosa, António

    2017-12-01

    Dignity therapy (DT) is a brief form of psychotherapy developed for patients living with a life-limiting illness that has demonstrated efficacy in treating several dimensions of end-of-life psychological distress. Our aim was to determine the influence of DT on demoralization syndrome (DS), the desire for death (DfD), and a sense of dignity (SoD) in terminally ill inpatients experiencing a high level of distress in a palliative care unit. A nonblinded phase II randomized controlled trial was conducted with 80 patients who were randomly assigned to one of two groups: the intervention group (DT + standard palliative care [SPC]) or the control group (SPC alone). The main outcomes were DS, DfD, and SoD, as measured according to DS criteria, the Desire for Death Rating Scale, and the Patient Dignity Inventory (PDI), respectively. All scales were assessed at baseline (day 1) and at day 4 of follow-up. This study is registered with http://www.controlled-trials.com/ISRCTN34354086. Of the 80 participants, 41 were randomized to DT and 39 to SPC. Baseline characteristics were similar between the two groups. DT was associated with a significant decrease in DS compared with SPC (DT DS prevalence = 12.1%; SPC DS prevalence = 60.0%; p Dignity therapy had a beneficial effect on the psychological distress encountered by patients near the end of life. Our research suggests that DT is an important psychotherapeutic approach that should be included in clinical care programs, and it could help more patients to cope with their end-of-life experiences.

  2. SU-E-J-55: End-To-End Effectiveness Analysis of 3D Surface Image Guided Voluntary Breath-Holding Radiotherapy for Left Breast

    Lin, M; Feigenberg, S [University of Maryland School of Medicine, Baltimore, MD (United States)

    2015-06-15

    Purpose To evaluate the effectiveness of using 3D-surface-image to guide breath-holding (BH) left-side breast treatment. Methods Two 3D surface image guided BH procedures were implemented and evaluated: normal-BH, taking BH at a comfortable level, and deep-inspiration-breath-holding (DIBH). A total of 20 patients (10 Normal-BH and 10 DIBH) were recruited. Patients received a BH evaluation using a commercialized 3D-surface- tracking-system (VisionRT, London, UK) to quantify the reproducibility of BH positions prior to CT scan. Tangential 3D/IMRT plans were conducted. Patients were initially setup under free-breathing (FB) condition using the FB surface obtained from the untaged CT to ensure a correct patient position. Patients were then guided to reach the planned BH position using the BH surface obtained from the BH CT. Action-levels were set at each phase of treatment process based on the information provided by the 3D-surface-tracking-system for proper interventions (eliminate/re-setup/ re-coaching). We reviewed the frequency of interventions to evaluate its effectiveness. The FB-CBCT and port-film were utilized to evaluate the accuracy of 3D-surface-guided setups. Results 25% of BH candidates with BH positioning uncertainty > 2mm are eliminated prior to CT scan. For >90% of fractions, based on the setup deltas from3D-surface-trackingsystem, adjustments of patient setup are needed after the initial-setup using laser. 3D-surface-guided-setup accuracy is comparable as CBCT. For the BH guidance, frequency of interventions (a re-coaching/re-setup) is 40%(Normal-BH)/91%(DIBH) of treatments for the first 5-fractions and then drops to 16%(Normal-BH)/46%(DIBH). The necessity of re-setup is highly patient-specific for Normal-BH but highly random among patients for DIBH. Overall, a −0.8±2.4 mm accuracy of the anterior pericardial shadow position was achieved. Conclusion 3D-surface-image technology provides effective intervention to the treatment process and ensures

  3. SU-E-J-55: End-To-End Effectiveness Analysis of 3D Surface Image Guided Voluntary Breath-Holding Radiotherapy for Left Breast

    Lin, M; Feigenberg, S

    2015-01-01

    Purpose To evaluate the effectiveness of using 3D-surface-image to guide breath-holding (BH) left-side breast treatment. Methods Two 3D surface image guided BH procedures were implemented and evaluated: normal-BH, taking BH at a comfortable level, and deep-inspiration-breath-holding (DIBH). A total of 20 patients (10 Normal-BH and 10 DIBH) were recruited. Patients received a BH evaluation using a commercialized 3D-surface- tracking-system (VisionRT, London, UK) to quantify the reproducibility of BH positions prior to CT scan. Tangential 3D/IMRT plans were conducted. Patients were initially setup under free-breathing (FB) condition using the FB surface obtained from the untaged CT to ensure a correct patient position. Patients were then guided to reach the planned BH position using the BH surface obtained from the BH CT. Action-levels were set at each phase of treatment process based on the information provided by the 3D-surface-tracking-system for proper interventions (eliminate/re-setup/ re-coaching). We reviewed the frequency of interventions to evaluate its effectiveness. The FB-CBCT and port-film were utilized to evaluate the accuracy of 3D-surface-guided setups. Results 25% of BH candidates with BH positioning uncertainty > 2mm are eliminated prior to CT scan. For >90% of fractions, based on the setup deltas from3D-surface-trackingsystem, adjustments of patient setup are needed after the initial-setup using laser. 3D-surface-guided-setup accuracy is comparable as CBCT. For the BH guidance, frequency of interventions (a re-coaching/re-setup) is 40%(Normal-BH)/91%(DIBH) of treatments for the first 5-fractions and then drops to 16%(Normal-BH)/46%(DIBH). The necessity of re-setup is highly patient-specific for Normal-BH but highly random among patients for DIBH. Overall, a −0.8±2.4 mm accuracy of the anterior pericardial shadow position was achieved. Conclusion 3D-surface-image technology provides effective intervention to the treatment process and ensures

  4. Effect of different rates of spent coffee grounds (SCG) on composting process, gaseous emissions and quality of end-product.

    Santos, Cátia; Fonseca, João; Aires, Alfredo; Coutinho, João; Trindade, Henrique

    2017-01-01

    The use of spent coffee grounds (SCG) in composting for organic farming is a viable way of valorising these agro-industrial residues. In the present study, four treatments with different amounts of spent coffee grounds (SCG) were established, namely, C 0 (Control), C 10 , C 20 and C 40 , containing 0, 10, 20 and 40% of SCG (DM), respectively; and their effects on the composting process and the end-product quality characteristics were evaluated. The mixtures were completed with Acacia dealbata L. shoots and wheat straw. At different time intervals during composting, carbon dioxide (CO 2 ), methane (CH 4 ) and nitrous oxide (N 2 O) emissions were measured and selected physicochemical characteristics of the composts were evaluated. During the composting process, all treatments showed a substantial decrease in total phenolics and total tannins, and an important increase in gallic acid. Emissions of greenhouse gases were very low and no significant difference between the treatments was registered. The results indicated that SCG may be successfully composted in all proportions. However C 40 , was the treatment which combined better conditions of composting, lower GHG emissions and better quality of end product. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. The cost-effectiveness of an eradication programme in the end game: Evidence from guinea worm disease.

    Fitzpatrick, Christopher; Sankara, Dieudonné P; Agua, Junerlyn Farah; Jonnalagedda, Lakshmi; Rumi, Filippo; Weiss, Adam; Braden, Matthew; Ruiz-Tiben, Ernesto; Kruse, Nicole; Braband, Kate; Biswas, Gautam

    2017-10-01

    Of the three diseases targeted for eradication by WHO, two are so-called Neglected Tropical Diseases (NTDs)-guinea worm disease (GWD) and yaws. The Guinea Worm Eradication Programme (GWEP) is in its final stages, with only 25 reported in 2016. However, global eradication still requires certification by WHO of the absence of transmission in all countries. We analyze the cost-effectiveness of the GWEP in the end game, when the number of cases is lower and the cost per case is higher than at any other time. Ours is the first economic evaluation of the GWEP since a World Bank study in 1997. Using data from the GWEP, we estimate the cost of the implementation, pre-certification and certification stages. We model cost-effectiveness in the period 1986-2030. We compare the GWEP to two alternative scenarios: doing nothing (no intervention since 1986) and control (only surveillance and outbreak response during 2016-2030). We report the cost per case averted, cost per disability adjusted life year (DALY) averted and cost per at-risk life year averted. We assess cost-effectiveness against a threshold of about one half GDP per capita (less than US$ 500 in low income countries). All costs are expressed in US$ of 2015. The GWEP cost an estimated US$ 11 (95% uncertainty interval, 4.70-12.49) per case averted in the period 1986-2030. The pre-certification and certification phases can cost as much as US$ 0.0041 and US$ 0.0015 per capita per year. The cost per DALY averted by the GWEP relative to doing nothing is estimated at US$ 222 (118-372) in 1986-2030. The GWEP is probably more cost-effective than control by the year 2030. The GWEP is certainly more cost-effective than control if willingness to pay for one year of life lived without the risk of GWD exceeds US$ 0.10. Even if economic costs are two times as high as the financial costs estimated for the period to 2020, the GWEP will still be cost-effective relative to doing nothing. Whether the GWEP turns out to be the most cost-effective

  6. The cost-effectiveness of an eradication programme in the end game: Evidence from guinea worm disease.

    Christopher Fitzpatrick

    2017-10-01

    Full Text Available Of the three diseases targeted for eradication by WHO, two are so-called Neglected Tropical Diseases (NTDs-guinea worm disease (GWD and yaws. The Guinea Worm Eradication Programme (GWEP is in its final stages, with only 25 reported in 2016. However, global eradication still requires certification by WHO of the absence of transmission in all countries. We analyze the cost-effectiveness of the GWEP in the end game, when the number of cases is lower and the cost per case is higher than at any other time. Ours is the first economic evaluation of the GWEP since a World Bank study in 1997.Using data from the GWEP, we estimate the cost of the implementation, pre-certification and certification stages. We model cost-effectiveness in the period 1986-2030. We compare the GWEP to two alternative scenarios: doing nothing (no intervention since 1986 and control (only surveillance and outbreak response during 2016-2030. We report the cost per case averted, cost per disability adjusted life year (DALY averted and cost per at-risk life year averted. We assess cost-effectiveness against a threshold of about one half GDP per capita (less than US$ 500 in low income countries. All costs are expressed in US$ of 2015.The GWEP cost an estimated US$ 11 (95% uncertainty interval, 4.70-12.49 per case averted in the period 1986-2030. The pre-certification and certification phases can cost as much as US$ 0.0041 and US$ 0.0015 per capita per year. The cost per DALY averted by the GWEP relative to doing nothing is estimated at US$ 222 (118-372 in 1986-2030. The GWEP is probably more cost-effective than control by the year 2030. The GWEP is certainly more cost-effective than control if willingness to pay for one year of life lived without the risk of GWD exceeds US$ 0.10.Even if economic costs are two times as high as the financial costs estimated for the period to 2020, the GWEP will still be cost-effective relative to doing nothing. Whether the GWEP turns out to be the most

  7. The death of recency: Relationship between end-state comfort and serial position effects in serial recall: Logan and Fischman (2011) revisited.

    Logan, Samuel W; Fischman, Mark G

    2015-12-01

    Two experiments examined the dynamic interaction between cognitive resources in short-term memory and bimanual object manipulation by extending recent research by Logan and Fischman (2011). In Experiment 1, 16 participants completed a bimanual end-state comfort task and a memory task requiring serial recall of 12 words or pictures. The end-state comfort task involved moving two glasses between two shelves. Participants viewed the items, performed the end-state comfort task, and then serially recalled the items. Recall was evaluated by the presence or absence of primacy and recency effects. The end-state comfort effect (ESCE) was assessed by the percentage of initial hand positions that allowed the hands to end comfortably. The main findings indicated that the ESCE was disrupted; the primacy effect remained intact; and the recency effect disappeared regardless of the type of memory item recalled. In Experiment 2, 16 participants viewed six items, performed an end-state comfort task, viewed another six items, and then serially recalled all 12 items. Results were essentially the same as in Experiment 1. Findings suggest that executing a bimanual end-state comfort task, regardless of when it is completed during a memory task, diminishes the recency effect irrespective of the type of memory item. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. End region and current consolidation effects upon the performance of an MHD channel for the ETF conceptual design

    Wang, S. Y.; Smith, J. M.

    1981-01-01

    The effects of MHD channel end regions on the overall power generation were considered. The peak plant thermodynamic efficiency was found to be slightly lower than for the active region (41%). The channel operating point for the peak efficiency was shifted to the supersonic mode (Mach No., M sub c approx. 1.1) rather than the previous subsonic operation (M sub c approx. 0.9). The sensitivity of the channel performance to the B-field, diffuser recovery coefficient, channel load parameter, Mach number, and combustor pressure is also discussed. In addition, methods for operating the channel in a constant-current mode are investigated. This mode is highly desirable from the standpoint of simplifying the current and voltage consolidation for the inverter system. This simplification could result in significant savings in the cost of the equipment. The initial results indicate that this simplification is possible, even under a strict Hall field constraint, with resonable plant thermodynamic efficiency (40.5%).

  9. 3D Finite Element Simulation of Micro End-Milling by Considering the Effect of Tool Run-Out

    Davoudinejad, Ali; Tosello, Guido; Parenti, Paolo

    2017-01-01

    Understanding the micro milling phenomena involved in the process is critical and difficult through physical experiments. This study presents a 3D finite element modeling (3D FEM) approach for the micro end-milling process on Al6082-T6. The proposed model employs a Lagrangian explicit finite...... element formulation to perform coupled thermo-mechanical transient analyses. FE simulations were performed at different cutting conditions to obtain realistic numerical predictions of chip formation, temperature distribution, and cutting forces by considering the effect of tool run-out in the model....... The predicted results of the model, involving the run-out influence, showed a good correlation with experimental chip formation and the signal shape of cutting forces....

  10. Effect of an advanced glycation end product-restricted diet and exercise on metabolic parameters in adult overweight men.

    Macías-Cervantes, Maciste Habacuc; Rodríguez-Soto, Juana María Dolores; Uribarri, Jaime; Díaz-Cisneros, Francisco José; Cai, Weijingi; Garay-Sevilla, Ma Eugenia

    2015-03-01

    The aim of this study was to review the effect of a low advanced glycation end product (AGEs) diet, exercise, and a combination of both on circulating AGE levels as well as on plasma lipids and anthropometric parameters. Forty-three overweight or obese men (body mass index [BMI] >25 kg/m(2)), 30 to 55 y, participated in a 12-wk study and were randomly assigned to one of three groups: low AGE diet, exercise with habitual food intake, or exercise plus low AGE diet. Exercise was for 45 min at 65% to 75% of their maximum heart rate three times a week. We measured somatometric variables (BMI and waist circumference), blood glucose, lipids, and serum AGEs (N(ε)-[Carboxymethyl]Lysine [CML] and methylglyoxal [MG]) at baseline and at 12 wk. Exercise alone was associated with decreased somatometric variables; the low AGE diet had the same effects and decreased serum CML and MG and when combined with exercise reproduced all these effects, but also decreased triacylglycerols and increased high-density lipoprotein. Correlation analysis showed that both changes of CML and MG correlated with changes in dietary AGEs (P diet reduces serum AGE and indices of body fat. The addition of exercise to the restricted diet has the same effects but also improves lipid profile. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  11. Designing Effective Interactions for Concordance around End-of-Life Care Decisions: Lessons from Hospice Admission Nurses

    Carey Candrian

    2017-04-01

    Full Text Available Near the end of life, hospice care reduces symptom-related distress and hospitalizations while improving caregiving outcomes. However, it takes time for a person to gain a sufficient understanding of hospice and decide to enroll. This decision is influenced by knowledge of hospice and its services, emotion and fear, cultural and religious beliefs, and an individual’s acceptance of diagnosis. Hospice admission interactions, a key influence in shaping decisions regarding hospice care, happen particularly late in the illness trajectory and are often complex, unpredictable, and highly variable. One goal of these interactions is ensuring patients and families have accurate and clear information about hospice care to facilitate informed decisions. So inconsistent are practices across hospices in consenting patients that a 2016 report from the Office of Inspector General (OIG entitled “Hospices should improve their election statements and certifications of terminal illness” called for complete and accurate election statements to ensure that hospice patients and their caregivers can make informed decisions and understand the costs and benefits of choosing hospice care. Whether complete and accurate information at initial admission visits improves interactions and outcomes is unknown. Our recent qualitative work investigating interactions between patients, caregivers, and hospice nurses has uncovered diverse and often diverging stakeholder-specific expectations and perceptions which if not addressed can create discordance and inhibit decision-making. This paper focuses on better understanding the communication dynamics and practices involved in hospice admission interactions in order to design more effective interactions and support the mandate from the OIG to provide hospice patients and their caregivers with accurate and complete information. This clarity is particularly important when discussing the non-curative nature of hospice care, and the

  12. Radiation effects on organic insulators for superconducting magnets. Annual progress report for period ending September 30, 1979

    Coltman, R.R. Jr.; Klabunde, C.E.; Kernohan, R.H.; Long, C.J.

    1979-11-01

    The most recent efforts in a program to study the effects of irradiation near 5 K on organic insulators for fusion reactors have extended the irradiation dose from 2 x 10 9 to 1 x 10 10 rads and have studied additional effects due to fast neutrons. When added to a gamma-ray dose of 2.4 x 10 9 rads, a fast-neutron fluence of 2.4 x 10 20 n/m 2 has little effect upon changes in electrical and mechanical properties. At this dose, present results are in agreement with previous results. At a dose of 1 x 10 10 rads, particle-filled epoxies are at end of life in terms of mechanical strength, while fiberglass-cloth-filled epoxies retain sufficient strength for use. Electrical-resistivity and voltage-breakdown values were reduced in some materials but remained in a usable range. Two sheet-type materials showed excellent stability in their electrical properties. Dimensional stability was generally good, except for one epoxy which showed considerable swelling at the higher dose

  13. Acute Exposure to a Precursor of Advanced Glycation End Products Induces a Dual Effect on the Rat Pancreatic Islet Function

    Ghada Elmhiri

    2014-01-01

    Full Text Available Aim. Chronic diseases are the leading cause of death worldwide. Advanced glycation end products, known as AGEs, are a major risk factor for diabetes onset and maintenance. Methylglyoxal (MG, a highly reactive metabolite of glucose, is a precursor for the generation of endogenous AGEs. Methods. In this current study we incubated in vitro pancreatic islets from adult rats in absence or presence of MG (10 μmol/l with different concentrations of glucose and different metabolic components (acetylcholine, epinephrine, potassium, forskolin, and leucine. Results. Different effects of MG on insulin secretion were evidenced. In basal glucose stimulation (5.6 mM, MG induced a significant (P<0.05 increase of insulin secretion. By contrast, in higher glucose concentrations (8.3 mM and 16.7 mM, MG significantly inhibited insulin secretion (P<0.05. In the presence of potassium, forskolin, and epinephrine, MG enhanced insulin secretion (P<0.05, while when it was incubated with acetylcholine and leucine, MG resulted in a decrease of insulin secretion (P<0.05. Conclusion. We suggest that MG modulates the secretion activity of beta-cell depending on its level of stimulation by other metabolic factors. These results provide insights on a dual acute effect of MG on the pancreatic cells.

  14. Advanced glycation end products impair function of late endothelial progenitor cells through effects on protein kinase Akt and cyclooxygenase-2

    Chen Qin; Dong Li; Wang Lian; Kang Lina; Xu Biao

    2009-01-01

    Endothelial progenitor cells (EPCs) exhibit impaired function in the context of diabetes, and advanced glycation end products (AGEs), which accumulate in diabetes, may contribute to this. In the present study, we investigated the mechanism by which AGEs impair late EPC function. EPCs from human umbilical cord blood were isolated, and incubated with AGE-modified albumin (AGE-albumin) at different concentrations found physiologically in plasma. Apoptosis, migration, and tube formation assays were used to evaluate EPC function including capacity for vasculogenesis, and expression of the receptor for AGEs (RAGE), Akt, endothelial nitric oxide synthase (eNOS), and cycloxygenase-2 (COX-2) were determined. Anti-RAGE antibody was used to block RAGE function. AGE-albumin concentration-dependently enhanced apoptosis and depressed migration and tube formation, but did not affect proliferation, of late EPCs. High AGE-albumin increased RAGE mRNA and protein expression, and decreased Akt and COX-2 protein expression, whilst having no effect on eNOS mRNA or protein in these cells. These effects were inhibited by co-incubation with anti-RAGE antibody. These results suggest that RAGE mediates the AGE-induced impairment of late EPC function, through down-regulation of Akt and COX-2 in these cells.

  15. Effect of abnormal outflow from end stages on concentration profile in uranium-stripping bank of PUREX flowsheet

    Ueda, Yoshinori; Matsumoto, Shiro

    2002-01-01

    The effect of the abnormal outflow from the end stages on the concentration profile was studied for the uranium-stripping bank to consider the design and the operation of the solvent extraction process, which eases the undesirable effects due to such abnormal flow. The abnormal outflow affected the concentration profile in the same manner as the decrease in the rate of the corresponding liquid flow rate entering the bank. The results suggested that the solvent extractor at the aqueous inlet stage in stripping banks and the solvent extractor at the organic inlet stage in extraction banks should be carefully designed to restrict the respective abnormal aqueous and organic outflows within the normal operational liquid flow rate range. Combining the result and the inherent phase separation behavior of the extractor suggested the possibility of designing the process with the self-controlled function of throughput, which eases the change of the concentration profile due to the undesirable increase in the rate of liquid flow rate entering the bank. Basically the proposed approaches are probably applicable to other general extraction and stripping processes. (author)

  16. The effect of an insulin releasing agent, BTS 67582, on advanced glycation end product formation in vitro.

    Simpson, A E; Jones, R B

    1999-01-01

    BTS 67582 (1,1-dimethyl-2-(2-morpholinophenyl) guanidine fumarate) is an insulin-releasing agent currently in phase II clinical trials. Its effect on advanced glycation end product (AGE) formation was measured in the BSA/D-glucose and L-lysine/glucose-6-phosphate assay systems and Amadori product formation was measured in the BSA/D-glucose assay system, following a 3 week incubation period. In the BSA/D-glucose assay system, 200 mM BTS 67582 caused an approximate 70% inhibition in AGE formation (pBTS 67582 and 200 mM aminoguanidine-HCl retarded Amadori product formation by 88% (pBTS 67582 at 20 mM and 2 mM was shown to inhibit Amadori product formation by 67% and 57%, respectively, (pBTS 67582 and 200 mM aminoguanidine-HCl were shown to inhibit AGE formation by about 70% and 96% (p<0.001), respectively. Tolbutamide (200 microM) and glibenclamide (100 microM) had no significant effect on AGE formation.

  17. Hard-hard coupling assisted anomalous magnetoresistance effect in amine-ended single-molecule magnetic junction

    Tang, Y.-H.; Lin, C.-J.; Chiang, K.-R.

    2017-06-01

    We proposed a single-molecule magnetic junction (SMMJ), composed of a dissociated amine-ended benzene sandwiched between two Co tip-like nanowires. To better simulate the break junction technique for real SMMJs, the first-principles calculation associated with the hard-hard coupling between a amine-linker and Co tip-atom is carried out for SMMJs with mechanical strain and under an external bias. We predict an anomalous magnetoresistance (MR) effect, including strain-induced sign reversal and bias-induced enhancement of the MR value, which is in sharp contrast to the normal MR effect in conventional magnetic tunnel junctions. The underlying mechanism is the interplay between four spin-polarized currents in parallel and anti-parallel magnetic configurations, originated from the pronounced spin-up transmission feature in the parallel case and spiky transmission peaks in other three spin-polarized channels. These intriguing findings may open a new arena in which magnetotransport and hard-hard coupling are closely coupled in SMMJs and can be dually controlled either via mechanical strain or by an external bias.

  18. End-Users, Front Ends and Librarians.

    Bourne, Donna E.

    1989-01-01

    The increase in end-user searching, the advantages and limitations of front ends, and the role of the librarian in end-user searching are discussed. It is argued that librarians need to recognize that front ends can be of benefit to themselves and patrons, and to assume the role of advisors and educators for end-users. (37 references) (CLB)

  19. Estimating teat canal cross-sectional area to determine the effects of teat-end and mouthpiece chamber vacuum on teat congestion.

    Penry, J F; Upton, J; Mein, G A; Rasmussen, M D; Ohnstad, I; Thompson, P D; Reinemann, D J

    2017-01-01

    The primary objective of this experiment was to assess the effect of mouthpiece chamber vacuum on teat-end congestion. The secondary objective was to assess the interactive effects of mouthpiece chamber vacuum with teat-end vacuum and pulsation setting on teat-end congestion. The influence of system vacuum, pulsation settings, mouthpiece chamber vacuum, and teat-end vacuum on teat-end congestion were tested in a 2×2 factorial design. The low-risk conditions for teat-end congestion (TEL) were 40 kPa system vacuum (Vs) and 400-ms pulsation b-phase. The high-risk conditions for teat-end congestion (TEH) were 49 kPa Vs and 700-ms b-phase. The low-risk condition for teat-barrel congestion (TBL) was created by venting the liner mouthpiece chamber to atmosphere. In the high-risk condition for teat-barrel congestion (TBH) the mouthpiece chamber was connected to short milk tube vacuum. Eight cows (32 quarters) were used in the experiment conducted during 0400 h milkings. All cows received all treatments over the entire experimental period. Teatcups were removed after 150 s for all treatments to standardize the exposure period. Calculated teat canal cross-sectional area (CA) was used to assess congestion of teat tissue. The main effect of the teat-end treatment was a reduction in CA of 9.9% between TEL and TEH conditions, for both levels of teat-barrel congestion risk. The main effect of the teat-barrel treatment was remarkably similar, with a decrease of 9.7% in CA between TBL and TBH conditions for both levels of teat-end congestion risk. No interaction between treatments was detected, hence the main effects are additive. The most aggressive of the 4 treatment combinations (TEH plus TBH) had a CA estimate 20% smaller than for the most gentle treatment combination (TEL plus TBL). The conditions designed to impair circulation in the teat barrel also had a deleterious effect on circulation at the teat end. This experiment highlights the importance of elevated mouthpiece

  20. Effectiveness of evacuating combustible gases by two parallel expellers closely coupled at one end of a gas pipeline

    Hawryluk, A.; Botros, K.K.

    2008-01-01

    Expeller performance has been formulated in terms of its capability to create suction pressure at the throat. This formulation has been used to assess the effectiveness of evacuating combustible gases from a pipeline section from one end using dual expellers mounted in parallel on two adjacent blow-down stacks. A general formulation was derived to address any situation of asymmetry in the stack resistance, asymmetry in the expellers' power as well overall pipeline resistance to suction flow. Solutions of the closed-form equations were obtained and presented on performance graphs showing the ratio of the suction flow using dual expellers to that using either one in a single mode. It was found that there are conditions at which expelling with dual expellers exceed that of either expeller operating alone. It was also shown that when asymmetric expellers are used, where one expeller is more powerful than the other, the benefits of using two expellers is realized up to a limiting degree of asymmetry, beyond which the weaker expeller could be stalled and then reverse flow

  1. Effect of ultrasonic agitation on push-out bond strength and adaptation of root-end filling materials.

    Alcalde, Murilo Priori; Vivan, Rodrigo Ricci; Marciano, Marina Angélica; Duque, Jussaro Alves; Fernandes, Samuel Lucas; Rosseto, Mariana Bailo; Duarte, Marco Antonio Hungaro

    2018-05-01

    This study evaluated the effect of ultrasonic agitation of mineral trioxide aggregate (MTA), calcium silicate-based cement (CSC), and Sealer 26 (S26) on adaptation at the cement/dentin interface and push-out bond strength. Sixty maxillary canines were divided into 6 groups ( n = 10): MTA, S26, and CSC, with or without ultrasonic activation (US). After obturation, the apical portions of the teeth were sectioned, and retrograde cavities were prepared and filled with cement by hand condensation. In the US groups, the cement was activated for 60 seconds: 30 seconds in the mesio-distal direction and 30 seconds in the buccal-lingual direction, using a mini Irrisonic insert coupled with the ultrasound transducer. After the materials set, 1.5-mm thick sections were obtained from the apexes. The presence of gaps and the bond between cement and dentin were analyzed using low-vacuum scanning electron microscopy. Push-out bond strength was measured using a universal testing machine. Ultrasonic agitation increased the interfacial adaptation of the cements. The S26 US group showed a higher adaptation value than MTA ( p < 0.05). US improved the push-out bond strength for all the cements ( p < 0.05). The US of retrograde filling cements enhanced the bond to the dentin wall of the root-end filling materials tested.

  2. Effectiveness of a nutrition education program for the prevention and treatment of malnutrition in end-stage renal disease.

    Hernández Morante, Juan José; Sánchez-Villazala, Almudena; Cutillas, Ruben Cañavate; Fuentes, Mari Carmen Conesa

    2014-01-01

    In end-stage renal disease (ESRD) patients, malnutrition is mainly addressed from a pharmacological but not educational point of view. Therefore, the objective of this study was to implement a nutritional education program (NEP) and to evaluate and compare its effectiveness in the treatment and prevention of malnutrition with oral supplementation (OS)-the standard treatment in these patients. This study was a longitudinal, 4-month prospective study. The study was conducted from January to May 2012 in the Hemodialysis Fresenius Medical Care Clinic of Murcia. One hundred twenty patients with ESRD undergoing hemodialysis were randomly assigned to a NEP or to OS. Patients assigned to the NEP group followed an educational program for 4 months that aimed to improve general nutritional knowledge and included culinary recommendations and an elaboration of balanced menus. The OS group received a nutritional supplement during the hemodialysis procedure. The main outcome measure was certain biochemical markers of nutritional and metabolic status. Nutrition knowledge was also evaluated. After 4 months of intervention, nutritional knowledge was increased in all patients (P values, and other biochemical parameters improved significantly in both groups (P < .050 in all cases), although other parameters such as C-reactive protein were impaired only in the NEP group. The NEP was at least as effective as OS for preventing and even treating malnutrition in patients with chronic renal failure on hemodialysis, improving their nutritional status, which may result in a long-term decrease in the mortality and morbidity of these patients. Copyright © 2014 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

  3. Differential Effects of Indoxyl Sulfate and Inorganic Phosphate in a Murine Cerebral Endothelial Cell Line (bEnd.3

    Andréa E. M. Stinghen

    2014-06-01

    Full Text Available Endothelial dysfunction plays a key role in stroke in chronic kidney disease patients. To explore the underlying mechanisms, we evaluated the effects of two uremic toxins on cerebral endothelium function. bEnd.3 cells were exposed to indoxyl sulfate (IS and inorganic phosphate (Pi. Nitric oxide (NO, reactive oxygen species (ROS and O2•– were measured using specific fluorophores. Peroxynitrite and eNOS uncoupling were evaluated using ebselen, a peroxide scavenger, and tetrahydrobiopterin (BH4, respectively. Cell viability decreased after IS or Pi treatment (p < 0.01. Both toxins reduced NO production (IS, p < 0.05; Pi, p < 0.001 and induced ROS production (p < 0.001. IS and 2 mM Pi reduced O2•– production (p < 0.001. Antioxidant pretreatment reduced ROS levels in both IS- and Pi-treated cells, but a more marked reduction of O2•– production was observed in Pi-treated cells (p < 0.001. Ebselen reduced the ROS production induced by the two toxins (p < 0.001; suggesting a role of peroxynitrite in this process. BH4 addition significantly reduced O2•– and increased NO production in Pi-treated cells (p < 0.001, suggesting eNOS uncoupling, but had no effect in IS-treated cells. This study shows, for the first time, that IS and Pi induce cerebral endothelial dysfunction by decreasing NO levels due to enhanced oxidative stress. However, Pi appears to be more deleterious, as it also induces eNOS uncoupling.

  4. Effect of dietary advanced glycation end products on postprandial appetite, inflammation, and endothelial activation in healthy overweight individuals

    Poulsen, Malene Wibe; Bak, Monika Judyta; Andersen, Jeanette Marker

    2014-01-01

    Advanced glycation end products (AGEs) formed in food during high-heat cooking may induce overeating and inflammation. We investigated whether AGE contents in a single meal affect postprandial appetite and markers of inflammation, endothelial activation, and oxidative stress.......Advanced glycation end products (AGEs) formed in food during high-heat cooking may induce overeating and inflammation. We investigated whether AGE contents in a single meal affect postprandial appetite and markers of inflammation, endothelial activation, and oxidative stress....

  5. Effects and safety of calcimimetics in end stage renal disease patients with secondary hyperparathyroidism: a meta-analysis.

    Qian Zhang

    Full Text Available PURPOSE: Secondary hyperparathyroidism (SHPT is one of the most common abnormalities of mineral metabolism in patients with chronic kidney disease. We performed a meta-analysis to determine the effect and safety of cinacalcet in SHPT patients receiving dialysis. METHODS: The meta-analysis was performed to determine the effect and safety of cinacalcet in SHPT patients receiving dialysis by using the search terms 'cinacalcet' or 'mimpara' or 'sensipar' or 'calcimimetic' or 'R586' on MEDLINE and EMBASE (January 1990 to February 2012. RESULTS: Fifteen trials were included, all of which were performed between 2000 and 2011 enrolling a total of 3387 dialysis patients. Our study showed that calcimimetic agents effectively ameliorated iPTH levels(WMD, -294.36 pg/mL; 95% CI, -322.76 to -265.95, P<0.001 in SHPT patients and reduced serum calcium (WMD, -0.81 mg/dL; 95% CI, -0.89 to -0.72, P<0.001 and phosphorus disturbances(WMD, -0.29 mg/dL; 95% CI, -0.41 to -0.17, P<0.001. The percentage of patients in whom there was a 30% decrease in serum iPTH levels by the end of the dosing was higher in cinacalcet group than that in control group(OR = 10.75, 95% CI: 6.65-17.37, P<0.001. However, no significant difference was found in all-cause mortality and all adverse events between calcimimetics and control groups(OR = 0.86, 95% CI: 0.46-1.60, P = 0.630; OR = 1.30, 95% CI: 0.78-2.18, P = 0.320, respectively. Compared with the control therapy, there was a significant increase in the episodes of hypocalcemia (OR = 2.46, 95% CI: 1.58-3.82, P<0.001, nausea (OR = 2.45, 95% CI: 1.29-4.66, P = 0.006, vomiting(OR = 2.78, 95% CI: 2.14-3.62, P<0.001, diarrhea(OR = 1.51, 95% CI: 1.04-2.20, P = 0.030 and upper respiratory tract infection (OR = 1.79, 95% CI: 1.20-2.66, P = 0.004in calcimimetics group. CONCLUSIONS: Calcimimetic treatment effectively improved biochemical parameters of SHPT patients receiving dialysis without increasing all-cause mortality and all adverse events.

  6. Effects of alternative deep bedding options on dairy cow preference, lying behavior, cleanliness, and teat end contamination.

    Wolfe, T; Vasseur, E; DeVries, T J; Bergeron, R

    2018-01-01

    Cows spend more time lying down when stalls are soft and dry, and bedding plays a key role in the comfort of the lying surface. The first objective of this study (experiment 1) was to compare cow preference for 2 types of alternative deep-bedding materials, switchgrass and switchgrass-lime, using wheat straw on a rubber mat as a control. Nine Holstein lactating cows were submitted in trios to a 3-choice preference test over 14 d (2 d of adaptation, 3 d of restriction to each stall, and 3 d of free access to all 3 stalls). Cows were housed individually in pens containing 3 stalls with different lying surfaces: (1) rubber mat with chopped wheat straw (WS); (2) deep-bedded switchgrass (SG); and (3) deep-bedded switchgrass, water, and lime mixture (SGL). The second objective (experiment 2) was to test, in freestall housing, the effects of these 3 types of bedding on lying behavior, cow cleanliness, and teat end bacterial contamination. Bedding treatments were compared in a 3 × 3 Latin square design using 24 cows split into groups of 8, with bedding materials being switched every 4 wk. Lying behavior was measured with data loggers in both studies. During experiment 1, cows chose to spend more time lying and had more frequent lying bouts on SG (9.4 h/d; 8.2 bouts/d) than on SGL (1.0 h/d; 0.9 bouts/d). They also spent more time standing and stood more frequently in stalls with SG (2.0 h/d; 10.1 bouts/d) than in those with SGL (0.6 h/d; 2.6 bouts/d), and stood longer in stalls with SG than with WS (0.6 h/d). In experiment 2, the total lying time, frequency of lying bouts, and mean lying bout duration were, on average, 9.7 ± 1.03 h/d, 8.2 ± 0.93 bouts/d, and 1.2 ± 0.06 h/bout, respectively, and did not differ between treatments. No treatment effects were found for cow cleanliness scores. Bedding dry matter was highest for SG (74.1%), lowest for SGL (63.5%), and intermediate for WS (68.6%) [standard error of the mean (SEM) = 1.57%]. This may explain the higher teat end

  7. Effects of hemodialysis on corneal and anterior chamber morphometry and intraocular pressure in patients with end-stage renal disease

    Mehtap Caglayan

    Full Text Available ABSTRACT Purpose: To evaluate the effects of hemodialysis (HD on corneal and anterior chamber morphometry, as well as intraocular pressure (IOP in patients with end-stage renal disease. Methods: Fifty right eyes were examined 30 minutes before and after HD. IOP was measured with a Goldmann applanation tonometer, and Ehlers' formula was used to calculate the corrected IOP values. The central corneal thickness (CCT, corneal volume (CV, keratometric values, anterior chamber depth (ACD, aqueous depth (AQD, anterior chamber volume (ACV, and anterior chamber angle (ACA in the nasal and temporal quadrants were measured with a Sirius anterior segment analysis system. Blood urea nitrogen levels, body mass, and systolic and diastolic arterial pressure were also measured before and after HD. Results: The mean age was 60.80 ± 13.38 (range: 35-80 years. The mean uncorrected and corrected IOP values decreased from 18.06 ± 3.91 and 18.31 ± 4.83 mmHg to 16.94 ± 3.87 and 16.95 ± 4.74 mmHg after HD, respectively (p=0.011 and p=0.003, respectively. The mean CCT decreased from 536.38 ± 24.73 to 533.18 ± 27.25 µm (p=0.002, and the mean CV decreased from 57.52 ± 3.15 to 55.68 ± 3.55 mm³ (p0.05 for all values. There were no significant correlations between the ocular and systemic parameters (p>0.05 for all correlations. Conclusions: Uncorrected IOP, corrected IOP, CCT, and CV values decreased after HD, whereas the anterior chamber morphometry values remained similar between the measurements performed before and after HD.

  8. Survival Outcomes in Resected Extrahepatic Cholangiocarcinoma: Effect of Adjuvant Radiotherapy in a Surveillance, Epidemiology, and End Results Analysis

    Vern-Gross, Tamara Z.; Shivnani, Anand T.; Chen, Ke; Lee, Christopher M.; Tward, Jonathan D.; MacDonald, O. Kenneth; Crane, Christopher H.; Talamonti, Mark S.; Munoz, Louis L.; Small, William

    2011-01-01

    Purpose: The benefit of adjuvant radiotherapy (RT) after surgical resection for extrahepatic cholangiocarcinoma has not been clearly established. We analyzed survival outcomes of patients with resected extrahepatic cholangiocarcinoma and examined the effect of adjuvant RT. Methods and Materials: Data were obtained from the Surveillance, Epidemiology, and End Results (SEER) program between 1973 and 2003. The primary endpoint was the overall survival time. Cox regression analysis was used to perform univariate and multivariate analyses of the following clinical variables: age, year of diagnosis, histologic grade, localized (Stage T1-T2) vs. regional (Stage T3 or greater and/or node positive) stage, gender, race, and the use of adjuvant RT after surgical resection. Results: The records for 2,332 patients were obtained. Patients with previous malignancy, distant disease, incomplete or conflicting records, atypical histologic features, and those treated with preoperative/intraoperative RT were excluded. Of the remaining 1,491 patients eligible for analysis, 473 (32%) had undergone adjuvant RT. After a median follow-up of 27 months (among surviving patients), the median overall survival time for the entire cohort was 20 months. Patients with localized and regional disease had a median survival time of 33 and 18 months, respectively (p < .001). The addition of adjuvant RT was not associated with an improvement in overall or cause-specific survival for patients with local or regional disease. Conclusion: Patients with localized disease had significantly better overall survival than those with regional disease. Adjuvant RT was not associated with an improvement in long-term overall survival in patients with resected extrahepatic bile duct cancer. Key data, including margin status and the use of combined chemotherapy, was not available through the SEER database.

  9. Effects of positive end-expiratory pressure on intraoperative core temperature in patients undergoing posterior spine surgery: prospective randomised trial.

    Seo, Hyungseok; Do Son, Je; Lee, Hyung-Chul; Oh, Hyung-Min; Jung, Chul-Woo; Park, Hee-Pyoung

    2018-03-01

    Objective Positive end-expiratory pressure (PEEP) causes carotid baroreceptor unloading, which leads to thermoregulatory peripheral vasoconstriction. However, the effects of PEEP on intraoperative thermoregulation in the prone position remain unknown. Methods Thirty-seven patients undergoing spine surgery in the prone position were assigned at random to receive either 10 cmH 2 O PEEP (Group P) or no PEEP (Group Z). The primary endpoint was core temperature 180 minutes after intubation. Secondary endpoints were delta core temperature (difference in core temperature between 180 minutes and immediately after tracheal intubation), incidence of intraoperative hypothermia (core temperature of peripheral vasoconstriction-related data. Results The median [interquartile range] core temperature 180 minutes after intubation was 36.1°C [35.9°C-36.2°C] and 36.0°C [35.9°C-36.4°C] in Groups Z and P, respectively. The delta core temperature and incidences of intraoperative hypothermia and peripheral vasoconstriction were not significantly different between the two groups. The peripheral vasoconstriction threshold (36.2°C±0.5°C vs. 36.7°C±0.6°C) was lower and the onset of peripheral vasoconstriction (66 [60-129] vs. 38 [28-70] minutes) was slower in Group Z than in Group P. Conclusions Intraoperative PEEP did not reduce the core temperature decrease in the prone position, although it resulted in an earlier onset and higher threshold of peripheral vasoconstriction.

  10. Paraho environmental data. Part IV. Land reclamation and revegetation. Part V. Biological effects. Part VI. Occupational health and safety. Part VII. End use

    Limbach, L.K.

    1982-06-01

    Characteristics of the environment and ecosystems at Anvil Points, reclamation of retorted shale, revegetation of retorted shale, and ecological effects of retorted shale are reported in the first section of this report. Methods used in screening shale oil and retort water for mutagens and carcinogens as well as toxicity studies are reported in the second section of this report. The third section contains information concerning the industrial hygiene and medical studies made at Anvil Points during Paraho research operations. The last section discusses the end uses of shale crude oil and possible health effects associated with end use. (DMC)

  11. Assessment of shoulder external rotation range-of-motion on throwing athletes: the effects of testing end-range determination (active versus passive).

    Ribeiro, A; Pascoal, A

    2015-07-01

    The purpose of this study was to compare the effects of active or passive end-range determination (supine position) for external rotation range of motion (ROM) in overhead throwing athletes and verify if athletes' ROM is similar to non-athletes. Kinematic data from the dominant shoulder of 24 healthy male subjects, divided into two groups (12 athletes and 12 non-athletes) were recorded at end-range external rotation, thoracohumeral and glenohumeral external rotation angles were compared and a 2-way repeated-measures ANOVA was used to calculate the effects of end-range determination (passive versus active) across groups (athlete and non-athlete). A significant main effect (p external end-range angles was observed while the highest end-range determination values were associated with passive motion. No differences were observed between the athletic or non-athletic groups for either thoracohumeral (p = 0.784) or glenohumeral (p = 0.364) motion.

  12. Effect of Hematodialysis Combined with Hemoperfusion on Insulin Resistance and Nutritional Status of Patients with End-Stage Diabetic Nephropathy

    Antony Raine

    2015-09-01

    Full Text Available Objective: To explore the effect of hematodialysis (HD combined with hemoperfusion (HP on the insulin resistance (IR and nutritional status of patients with end-stage diabetic nephropathy (ESDN. Methods: Eighty-six patients with ESDN were randomly divided into group A (n=28, group B (n=30 and group C (n=28, and another 24 healthy volunteers were selected as control group. Groups A, B and C were respectively treated with routine HD, HD combined with hemodiafiltration (HDF as well as HD combined with HP. The levels of C-reactive protein (CRP, tumor necrosis factor α (TNF-α and interleukin-6 (IL-6 as well as the changes ofurea nitrogen(Scr, fasting blood glucose (FBG, fasting insulin (FINS, homeostasis model assessment of insulin resistance (Homa-IR, hemoglobin (Hb, albumin (Alb and body mass index (BMI were compared among groups before and 12 weeks after treatment. (BUN, creatinine Results: 12 weeks after treatment, the levels of CRP, TNF-α and IL-6 in group A did not change obviously, whereas those in groups B and C decreased dramatically when compared with treatment before (P<0.05 or P<0.01, in which the decreased range in group C was the most significant, but it was still higher than in control group (P<0.01. There was no statistical significance among three groups with regard to the levels of BUN and Scr before and 12 weeks after treatment (P>0.05. Compared with treatment before, FBG and FINS levels as well as Homa-IR reduced (P<0.05 or P<0.01, Hb, Alb and BMI elevated markedly in group C 12 weeks after treatment (P<0.01, while those in groups A and B did not change conspicuously (P>0.05. FBG, FINS and Homa-IR were all lower, but Hb, Alb and BMI were markedly higher in group C than in groups A and B 12 weeks after treatment, and significant differences were shown (P<0.05 or P<0.01.Conclusion: HD combined with HP can effectively remove the mid- and macro-molecular inflammatory mediators in the patients with ESDN, alleviate IR and ameliorate

  13. Effects of cardiac resynchronization therapy in patients with inotrope-dependent class IV end-stage heart failure

    Ikutaro Nakajima

    2013-12-01

    Conclusion: CRT did not result in significant reverse remodeling in patients with inotrope-dependent class IV end-stage HF. However, it contributed to dramatically improve the cardiovascular outcomes at least in the short-term period in some patients.

  14. Benazepril combined with either amlodipine or hydrochlorothiazide is more effective than monotherapy for blood pressure control and prevention of end-organ injury in hypertensive Dahl rats.

    Zhou, Ming-Sheng; Jaimes, Edgar A; Raij, Leopoldo

    2006-07-01

    We studied the effect of hydrochlorothiazide (HCTZ), the angiotensin-converting enzyme inhibitor benazepril, the calcium channel blocker amlodipine, or a combination of benazepril/amlodipine or benazepril/HCTZ on systolic blood pressure (BP) and end-organ injury (left ventricular hypertrophy, proteinuria, and endothelium-dependent relaxation to acetylcholine) in hypertensive Dahl salt-sensitive rats fed either a normal-salt (0.5% NaCl) or high-salt (4% NaCl) diet for 6 weeks. Rats fed a high-salt diet developed hypertension and significant end-organ injury. Monotherapy with HCTZ (75 mg/L in drinking water) or amlodipine (10 mg/kg/day by gavage) reduced systolic BP and proteinuria; benazepril (40 mg/kg/day by gavage) decreased proteinuria without significantly lowering systolic BP. In rats receiving a high-salt diet, only HCTZ reduced left ventricular hypertrophy, whereas endothelium-dependent relaxation was improved by amlodipine and benazepril but not by HCTZ. Combining benazepril with either amlodipine or HCTZ dramatically reduced systolic BP and end-organ injury. These data clearly support clinical studies suggesting that combination therapy is more effective than monotherapy for systolic BP control and prevention of end-organ injury. Complementary mechanisms of action of agents from different antihypertensive classes appear to facilitate the greater benefit on BP and end-organ injury.

  15. Effect Of Open Ended Teaching Learning Approach On Secondary School Students Mathematics Achievement In Learning Three Dimensional Geometry

    Chogo C.N.

    2017-12-01

    Full Text Available Mathematics is globally valued for use by an individual and society. It plays a significant role in the development of modern science and technology. Despite its importance students motivation to learn and achievement at national examinations globally and at the KCSE mathematics examination in Kenya particularly has been dismal over the years. The learners low achievement in the subject has been attributed to the didactic teaching methods that the teachers use among other factors. The study of geometry in Mathematics poses a number of difficulties to learners which are different in nature from those of arithmetic and algebra. This is because geometry is primarily abstract in nature. The purpose of this study was to determine the effects of Open Ended Teaching and Learning Approach OETLA on Secondary School students mathematics achievement in learning Three Dimensional Geometry 3DG. The study employed Solomon four non-equivalent control group design. The two experimental groups E1amp E2 received OETLA treatment while the control groups C1ampC2 were taught using the conventional teaching and learning methods. Only E1amp C1 took a pre-test and a post test for all the groups. The target population for this study was form four 17 year old students of secondary schools in Marani Sub County in Kisii County. Purposive sampling was used to obtain the four county mixed-sex secondary schools for the study. A total of 152 students formed the sample size. Students Mathematics Achievement Test SMAT was used to collect data. The instruments were validated by three experts from the department of curriculum and instruction of Egerton University and three Secondary School Mathematics Heads of Department. The reliability of the instruments were established using Cronbachs Alpha. A reliability coefficient of 0.92 was obtained and thus considered acceptable. The SMAT was administered to two groups as a pretest before the treatment and as a posttest to all the four

  16. Why do NRM regional planning processes and tools have limited effect? Presenting the perspective of the end user

    Dana Reiter

    2017-01-01

    Full Text Available Natural resource managers are required to prepare a plan for managing the natural resources in their regions. Environmental decision support systems (EDSS have been developed to assist managers and stakeholders make decisions about complex natural resource problems. Research has shown that these EDSS are valuable and used internationally. However, sustainability science literature reports that too often these natural resource management (NRM plans are not consulted upon completion, and the EDSS are no longer used. To gain insight into why the EDSS are no longer used after the research and development phase of the NRM planning project, we have asked the stakeholders, as end users of the EDSS tool themselves, to share their perceptions of, and experience with development of the tool and then, the tool itself. This paper reports on the perspectives of the end users of an EDSS used in a South Australian NRM planning project from 2011 to 2013. The findings were mixed in that they show that the majority (90% of respondents felt the EDSS had overall value, yet it was virtually abandoned after the completion of the planning project. Further, just over half of respondents reported that they thought that the EDSS should have been used on a regular basis after the pilot project ended. We conclude that genuine capacity development, aided by the EDSS, took place during the project. However, the lack of use of the EDSS after the pilot project finished was the result of failures both with researcher follow up and especially with the lack of commitment from government agencies who support and influence the array of end users. Unless agencies commit to the changed practices identified by end users that would support ongoing use of EDSS it is inevitable that the legacy value of EDSS development will remain limited.

  17. Effect of parathyroidectomy and cinacalcet on quality of life in patients with end-stage renal disease-related hyperparathyroidism : A systematic review

    van der Plas, Willemijn Y.; Dulfer, Roderick R.; Engelsman, Anton F.; Vogt, Liffert; de Borst, Martin H.; van Ginhoven, Tessa M.; Kruijff, Schelto

    2017-01-01

    Background. Patients with end-stage renal disease (ESRD) have a decreased quality of life (QoL), which is attributable in part to ESRD-related hyperparathyroidism (HPT). Both cinacalcet and parathyroidectomy (PTx) are treatments for advanced HPT, but their effects on QoL are unclear. We performed a

  18. Arteriovenous renal replacement therapy in end-stage left-sided heart failure patients has a detrimental effect on patients with impaired right ventricular function

    Evangelos Repasos, MD

    2017-07-01

    Conclusion: In patients with end-stage HF, the creation of AVC for intermittent RRT was followed by a significant increase in morbidity and mortality in comparison to the safe and effective placement of permanent central venous catheters. Patients with elevated PVR seem to comprise a group at high risk for adverse outcomes after central catheter insertion.

  19. Effects of Inhaled Fenoterol and Positive End-Expiratory Pressure on the Respiratory Mechanics of Patients with Chronic Obstructive Pulmonary Disease

    Claude Guerin

    2005-01-01

    Full Text Available BACKGROUND: During acute ventilatory failure in patients with chronic obstructive pulmonary disease (COPD, applying external positive end-expiratory pressure (PEEPe will reopen small airways and, thus, may enhance peripheral deposition as well as the physiological effects of inhaled beta-2 agonists.

  20. Effect of parathyroidectomy and cinacalcet on quality of life in patients with end-stage renal disease-related hyperparathyroidism: a systematic review

    van der Plas, Willemijn Y.; Dulfer, Roderick R.; Engelsman, Anton F.; Vogt, Liffert; de Borst, Martin H.; van Ginhoven, Tessa M.; Kruijff, Schelto

    2017-01-01

    Background. Patients with end-stage renal disease (ESRD) have a decreased quality of life (QoL), which is attributable in part to ESRD-related hyperparathyroidism (HPT). Both cinacalcet and parathyroidectomy (PTx) are treatments for advanced HPT, but their effects on QoL are unclear. We performed a

  1. Effects of recruitment maneuver and positive end-expiratory pressure on respiratory mechanics and transpulmonary pressure during laparoscopic surgery.

    Cinnella, Gilda; Grasso, Salvatore; Spadaro, Savino; Rauseo, Michela; Mirabella, Lucia; Salatto, Potito; De Capraris, Antonella; Nappi, Luigi; Greco, Pantaleo; Dambrosio, Michele

    2013-01-01

    The authors tested the hypothesis that during laparoscopic surgery, Trendelenburg position and pneumoperitoneum may worsen chest wall elastance, concomitantly decreasing transpulmonary pressure, and that a protective ventilator strategy applied after pneumoperitoneum induction, by increasing transpulmonary pressure, would result in alveolar recruitment and improvement in respiratory mechanics and gas exchange. In 29 consecutive patients, a recruiting maneuver followed by positive end-expiratory pressure 5 cm H(2)O maintained until the end of surgery was applied after pneumoperitoneum induction. Respiratory mechanics, gas exchange, blood pressure, and cardiac index were measured before (T(BSL)) and after pneumoperitoneum with zero positive end-expiratory pressure (T(preOLS)), after recruitment with positive end-expiratory pressure (T(postOLS)), and after peritoneum desufflation with positive end-expiratory pressure (T(end)). Esophageal pressure was used for partitioning respiratory mechanics between lung and chest wall (data are mean ± SD): on T(preOLS), chest wall elastance (E(cw)) and elastance of the lung (E(L)) increased (8.2 ± 0.9 vs. 6.2 ± 1.2 cm H(2)O/L, respectively, on T(BSL); P = 0.00016; and 11.69 ± 1.68 vs. 9.61 ± 1.52 cm H(2)O/L on T(BSL); P = 0.0007). On T(postOLS), both chest wall elastance and E(L) decreased (5.2 ± 1.2 and 8.62 ± 1.03 cm H(2)O/L, respectively; P = 0.00015 vs. T(preOLS)), and Pao(2)/inspiratory oxygen fraction improved (491 ± 107 vs. 425 ± 97 on T(preOLS); P = 0.008) remaining stable thereafter. Recruited volume (the difference in lung volume for the same static airway pressure) was 194 ± 80 ml. Pplat(RS) remained stable while inspiratory transpulmonary pressure increased (11.65 + 1.37 cm H(2)O vs. 9.21 + 2.03 on T(preOLS); P = 0.007). All respiratory mechanics parameters remained stable after abdominal desufflation. Hemodynamic parameters remained stable throughout the study. In patients submitted to laparoscopic surgery in

  2. Acute effects of static stretching on peak and end-range hamstring-to-quadriceps functional ratios

    Sekir, Ufuk; Arabaci, Ramiz; Akova, Bedrettin

    2015-01-01

    AIM: To evaluate if static stretching influences peak and end-range functional hamstring-to-quadriceps (H/Q) strength ratios in elite women athletes. METHODS: Eleven healthy female athletes in an elite competitive level participated to the study. All the participants fulfilled the static stretching or non-stretching (control) intervention protocol in a randomized design on different days. Two static unassisted stretching exercises, one in standing and one in sitting position, were used to stretch both the hamstring and quadriceps muscles during these protocols. The total time for the static stretching was 6 ± 1 min. The isokinetic peak torque measurements for the hamstring and quadriceps muscles in eccentric and concentric modes and the calculations for the functional H/Q strength ratios at angular velocities of 60°/s and 180°/s were made before (pre) and after (post) the control or stretching intervention. The strength measurements and functional strength ratio calculations were based during the entire- and end-range of knee extension. RESULTS: The pre-test scores for quadriceps and hamstring peak torque and end range values were not significantly different between the groups (P > 0.05). Subsequently, although the control group did not exhibit significant changes in quadriceps and hamstring muscle strength (P > 0.05), static stretching decreased eccentric and concentric quadriceps muscle strength at both the 60°/s and 180°/s test speeds (P hamstring muscle strength at both the 60°/s and 180°/s test speeds (P 0.05). Furthermore, the functional H/Q strength ratios exhibited no significant alterations during the entire and end ranges of knee extension both in the static stretching or the control intervention (P > 0.05). CONCLUSION: According to our results, static stretching routine does not influence functional H/Q ratio. Athletes can confidently perform static stretching during their warm-up routines. PMID:26495249

  3. The effectiveness of communication-skills training interventions in end-of-life noncancer care in acute hospital-based services: A systematic review.

    Lord, Laura; Clark-Carter, David; Grove, Amy

    2016-08-01

    A systematic review was conducted in order to explore the effectiveness of communication-skills training interventions in end-of-life care with noncancer acute-based healthcare staff. Articles were included if they (1) focused on communication-skills training in end-of-life/palliative care for noncancer acute-based staff and (2) reported an outcome related to behavior change with regard to communication. Sixteen online databases were searched, which resulted in 4,038 potential articles. Screening of titles left 393 articles that met the inclusion criteria. Abstracts (n = 346) and full-text articles (n = 47) were reviewed, leaving 10 papers that met the criteria for our review. All articles explored the effect of communication-skills training on aspects of staff behavior; one study measured the effect on self-efficacy, another explored the impact on knowledge and competence, and another measured comfort levels in discussing the end of life with patients/families. Seven studies measured a number of outcomes, including confidence, attitude, preparedness, stress, and communication skills. Few studies have focused on end-of-life communication-skills training in noncancer acute-based services. Those that do have report positive effects on staff behavior with regard to communication about the end of life with patients and families. The studies varied in terms of the population studied and the health services involved, and they scored only moderately or weakly on quality. It is a challenge to draw a definite conclusion about the effectiveness of training interventions in end-of-life communication because of this. However, the findings from our review demonstrate the potential effectiveness of a range of training interventions with healthcare professionals on confidence, attitude, self-efficacy, and communication skills. Further research is needed to fully explore the effectiveness of existing training interventions in this population, and evidence using objective measures

  4. Possible climate effects of the CAMP intrusive and extrusive activity and its influence on the end-Triassic mass extinction

    Marzoli, A.; Davies, J.; Valeriani, L.; Preto, N.; Cirilli, S.; Panfili, G.; Dal Corso, J.; Vasconcellos, E.; Ernesto, M.; Youbi, N.; Callegaro, S.

    2017-12-01

    The end-Triassic global climate changes were probably triggered by the emplacement of the CAMP (Central Atlantic magmatic province). Here we explore the possibility that CAMP intrusions triggered global warming, while CAMP eruptions triggered short-lived cooling events. The main phase of the end-Triassic environmental changes and mass extinction was marked by two carbon isotopic excursions (CIEs). Based on stratigraphic and geochronologic data, we show that the earliest CAMP intrusions were emplaced at ca. 201.6 Ma prior to the first CIE (Davies et al., 2017). The main phase of CAMP magmatism started during the first CIE at ca. 201.5 Ma and continued until the second CIE and the Triassic-Jurassic boundary (at ca. 201.3 Ma). In particular, intrusion of the over 1 million cubic km of basaltic sills in Amazonia (Brazil) and of widespread sills from North America and Africa occurred within this interval. Multidisciplinary analyses show that organic matter rich sediments close to the sills from Brazil, Morocco, and the USA underwent contact metamorphism and organic carbon depletion. Such process may have released large amounts of thermogenic gases (CO2 and CH4) leading to global perturbation of the carbon cycle and to global warming. The timing of CAMP volcanic eruptions is well constrained by combined geochronologic, stratigraphic and palynologic data. In Morocco, newly observed palynological assemblages for sediments at the top of the lava piles are nearly identical to those found at the base of the volcanic sequences. These new data combined with carbon isotopic data indicate that over 95% of the CAMP lava flows in Morocco erupted during a short time interval at the very beginning of the end-Triassic extinction interval. A similar scenario applies possibly to the lava flows from North America. CAMP basalts are quite sulfur rich (up to 1800 ppm) suggesting that CAMP eruptions emitted large amounts of SO2. Such emissions lead possibly to short-lived cooling events

  5. Irradiation induced effects in the FE-I4 front-end chip of the ATLAS IBL detector

    La Rosa, Alessandro; The ATLAS collaboration

    2016-01-01

    The ATLAS Insertable B-Layer (IBL) detector was installed into the ATLAS experiment in 2014 and has been in operation since 2015. During the first year of IBL data taking an increase of the low voltage currents produced by the FE-I4 front-end chip was observed and this increase was traced back to the radiation damage in the chip. The dependence of the current on the total-ionising dose and temperature has been tested with Xray and proton irradiations and will be presented in this paper together with the detector operation guidelines.

  6. Effect of machining parameters on surface integrity of silicon carbide ceramic using end electric discharge milling and mechanical grinding hybrid machining

    Ji, Renjie; Liu, Yonghong; Zhang, Yanzhen; Cai, Baoping; Li, Xiaopeng; Zheng, Chao

    2013-01-01

    A novel hybrid process that integrates end electric discharge (ED) milling and mechanical grinding is proposed. The process is able to effectively machine a large surface area on SiC ceramic with good surface quality and fine working environmental practice. The polarity, pulse on-time, and peak current are varied to explore their effects on the surface integrity, such as surface morphology, surface roughness, micro-cracks, and composition on the machined surface. The results show that positive tool polarity, short pulse on-time, and low peak current cause a fine surface finish. During the hybrid machining of SiC ceramic, the material is mainly removed by end ED milling at rough machining mode, whereas it is mainly removed by mechanical grinding at finish machining mode. Moreover, the material from the tool can transfer to the workpiece, and a combination reaction takes place during machining.

  7. Effects of sodium bicarbonate on the end-tidal CO2, PaCO2, HCO3-, PH and cerebral blood flow

    Komatani, Akio; Akutsu, Tooru; Yoshida, Michihiko; Yamaguchi, Koichi; Seo, Hiroshi

    1992-01-01

    To estimate the quantitative reactivity of cerebral blood flow (CBF), the effects of sodium bicarbonate on the end-tidal CO 2 , arterial partial pressure of CO 2 (PaCO 2 ), HCO 3 - , pH and CBF were examined. The CBF was measured by 133 Xe inhalation method with ring type SPECT (HEADTOME). Activation study with sodium bicarbonate administration was performed after 30 minutes of resting study, and the reactivity of each parameters was investigated. The arterial HCO 3 - and pH increased with similar reactivity, but PaCO 2 , end-tidal CO 2 and CBF in the non-injured hemisphere changed with irregular reactivity. The excellent correlation between PaCO 2 and end-tidal CO 2 was vanished by the administration of sodium bicarbonate. The reactivity of CBF did not correlate with reactivity of PaCO 2 and end-tidal CO 2 , but correlated with arterial HCO 3 - and pH. Thus the measurement of arterial HCO 3 - and pH may be indispensable to estimate the CBF reactivity with the administration of sodium bicarbonate. (author)

  8. Effects of sodium bicarbonate on the end-tidal CO[sub 2], PaCO[sub 2], HCO[sub 3][sup -], PH and cerebral blood flow

    Komatani, Akio; Akutsu, Tooru; Yoshida, Michihiko; Yamaguchi, Koichi; Seo, Hiroshi (Yamagata Univ. (Japan). School of Medicine)

    1992-09-01

    To estimate the quantitative reactivity of cerebral blood flow (CBF), the effects of sodium bicarbonate on the end-tidal CO[sub 2], arterial partial pressure of CO[sub 2] (PaCO[sub 2]), HCO[sub 3][sup -], pH and CBF were examined. The CBF was measured by [sup 133]Xe inhalation method with ring type SPECT (HEADTOME). Activation study with sodium bicarbonate administration was performed after 30 minutes of resting study, and the reactivity of each parameters was investigated. The arterial HCO[sub 3][sup -] and pH increased with similar reactivity, but PaCO[sub 2], end-tidal CO[sub 2] and CBF in the non-injured hemisphere changed with irregular reactivity. The excellent correlation between PaCO[sub 2] and end-tidal CO[sub 2] was vanished by the administration of sodium bicarbonate. The reactivity of CBF did not correlate with reactivity of PaCO[sub 2] and end-tidal CO[sub 2], but correlated with arterial HCO[sub 3][sup -] and pH. Thus the measurement of arterial HCO[sub 3][sup -] and pH may be indispensable to estimate the CBF reactivity with the administration of sodium bicarbonate. (author).

  9. A pilot study on the effectiveness of anticipatory grief therapy for elderly facing the end of life.

    Cheng, Joanna Oi-Yue; Lo, Raymond; Chan, Faye; Woo, Jean

    2010-01-01

    This pilot study evaluates the benefits of anticipatory grief therapy (AGT) for day hospice patients and long-term care (LTC) residents with cancer and non-malignant chronic diseases. Twenty-six elderly people (69.2 percent female; average age 81.8 years) participated in experiential, expressive activities and discussions during AGT. The McGill Quality of Life Questionnaire-Hong Kong version and the 15-item Geriatrics Depression Scale (Chinese version) were administered immediately before and after AGT, and at a four-week follow-up. Focus groups were held to collect qualitative feedback. Significant post-AGT improvements were found in physical (Z = -2.12, p art, perceived benefits of AGT, and comments and suggestions for improving AGT in the future. We conclude that AGT delivered in both day hospice and LTC settings could be acceptable, feasible, and useful for elderly people facing the end of life.

  10. Effect of dignity therapy on distress and end-of-life experience in terminally ill patients: a randomised controlled trial.

    Chochinov, Harvey Max; Kristjanson, Linda J; Breitbart, William; McClement, Susan; Hack, Thomas F; Hassard, Tom; Harlos, Mike

    2011-08-01

    Dignity therapy is a unique, individualised, short-term psychotherapy that was developed for patients (and their families) living with life-threatening or life-limiting illness. We investigated whether dignity therapy could mitigate distress or bolster the experience in patients nearing the end of their lives. Patients (aged ≥18 years) with a terminal prognosis (life expectancy ≤6 months) who were receiving palliative care in a hospital or community setting (hospice or home) in Canada, USA, and Australia were randomly assigned to dignity therapy, client-centred care, or standard palliative care in a 1:1:1 ratio. Randomisation was by use of a computer-generated table of random numbers in blocks of 30. Allocation concealment was by use of opaque sealed envelopes. The primary outcomes--reductions in various dimensions of distress before and after completion of the study--were measured with the Functional Assessment of Chronic Illness Therapy Spiritual Well-Being Scale, Patient Dignity Inventory, Hospital Anxiety and Depression Scale, items from the Structured Interview for Symptoms and Concerns, Quality of Life Scale, and modified Edmonton Symptom Assessment Scale. Secondary outcomes of self-reported end-of-life experiences were assessed in a survey that was undertaken after the completion of the study. Outcomes were assessed by research staff with whom the participant had no previous contact to avoid any possible response bias or contamination. Analyses were done on all patients with available data at baseline and at the end of the study intervention. This study is registered with ClinicalTrials.gov, number NCT00133965. 165 of 441 patients were assigned to dignity therapy, 140 standard palliative care, and 136 client-centred care. 108, 111, and 107 patients, respectively, were analysed. No significant differences were noted in the distress levels before and after completion of the study in the three groups. For the secondary outcomes, patients reported that

  11. Characterizing harmful advanced glycation end-products (AGEs) and ribosylated aggregates of yellow mustard seed phytocystatin: Effects of different monosaccharides

    Ahmed, Azaj; Shamsi, Anas; Bano, Bilqees

    2017-01-01

    Advanced glycation end products (AGEs) are at the core of variety of diseases ranging from diabetes to renal failure and hence gaining wide consideration. This study was aimed at characterizing the AGEs of phytocystatin isolated from mustard seeds (YMP) when incubated with different monosaccharides (glucose, ribose and mannose) using fluorescence, ultraviolet, circular dichroism (CD) spectroscopy and microscopy. Ribose was found to be the most potent glycating agent as evident by AGEs specific fluorescence and absorbance. YMP exists as a molten globule like structure on day 24 as depicted by high ANS fluorescence and altered intrinsic fluorescence. Glycated YMP as AGEs and ribose induced aggregates were observed at day 28 and 32 respectively. In our study we have also examined the anti-aggregative potential of polyphenol, resveratrol. Our results suggested the anti-aggregative behavior of resveratrol as it prevented the in vitro aggregation of YMP, although further studies are required to decode the mechanism by which resveratrol prevents the aggregation.

  12. The Effects of Teacher and Teacher-librarian High-end Collaboration on Inquiry-based Project Reports and School Monthly Test Scores of Fifth-grade Students

    Hai-Hon Chen

    2015-01-01

    The purpose of this study was twofold. The first purpose was to establish the high level collaboration of integrated instruction model between social studies teacher and teacher-librarian. The second purpose was to investigate the effects of high-end collaboration on the individual and groups’ inquiry-based project reports, as well as monthly test scores of fifth-grade students. A quasi-experimental method was adopted, two classes of elementary school fifth graders in Tainan Municipal city, T...

  13. An effective approach for identification of in vivo protein-DNA binding sites from paired-end ChIP-Seq data

    Wilson Zoe A

    2010-02-01

    Full Text Available Abstract Background ChIP-Seq, which combines chromatin immunoprecipitation (ChIP with high-throughput massively parallel sequencing, is increasingly being used for identification of protein-DNA interactions in vivo in the genome. However, to maximize the effectiveness of data analysis of such sequences requires the development of new algorithms that are able to accurately predict DNA-protein binding sites. Results Here, we present SIPeS (Site Identification from Paired-end Sequencing, a novel algorithm for precise identification of binding sites from short reads generated by paired-end solexa ChIP-Seq technology. In this paper we used ChIP-Seq data from the Arabidopsis basic helix-loop-helix transcription factor ABORTED MICROSPORES (AMS, which is expressed within the anther during pollen development, the results show that SIPeS has better resolution for binding site identification compared to two existing ChIP-Seq peak detection algorithms, Cisgenome and MACS. Conclusions When compared to Cisgenome and MACS, SIPeS shows better resolution for binding site discovery. Moreover, SIPeS is designed to calculate the mappable genome length accurately with the fragment length based on the paired-end reads. Dynamic baselines are also employed to effectively discriminate closely adjacent binding sites, for effective binding sites discovery, which is of particular value when working with high-density genomes.

  14. The use of opioids at the end of life: the knowledge level of Dutch physicians as a potential barrier to effective pain management

    Boddaert Manon SA

    2010-11-01

    which it seems likely that an improvement can improve the quality of pain management at the end of life for many patients in the Netherlands: 1palliative sedation; 2expected effect of opioids on survival; and 3 opioid rotation.

  15. A Study of the Effect of the Front-End Styling of Sport Utility Vehicles on Pedestrian Head Injuries

    Guanjun Zhang

    2018-01-01

    Full Text Available Background. The number of sport utility vehicles (SUVs on China market is continuously increasing. It is necessary to investigate the relationships between the front-end styling features of SUVs and head injuries at the styling design stage for improving the pedestrian protection performance and product development efficiency. Methods. Styling feature parameters were extracted from the SUV side contour line. And simplified finite element models were established based on the 78 SUV side contour lines. Pedestrian headform impact simulations were performed and validated. The head injury criterion of 15 ms (HIC15 at four wrap-around distances was obtained. A multiple linear regression analysis method was employed to describe the relationships between the styling feature parameters and the HIC15 at each impact point. Results. The relationship between the selected styling features and the HIC15 showed reasonable correlations, and the regression models and the selected independent variables showed statistical significance. Conclusions. The regression equations obtained by multiple linear regression can be used to assess the performance of SUV styling in protecting pedestrians’ heads and provide styling designers with technical guidance regarding their artistic creations.

  16. Effects of End CAP and Aspect Ratio on Transmission of Sound across a Truss-Like Periodic Double Panel

    EL-RAHEB, M.; WAGNER, P.

    2002-02-01

    Transmission of sound across 2-D truss-like periodic double panels separated by an air gap and in contact with an acoustic fluid on the external faces is analyzed. Each panel is made of repeated cells. Combining the transfer matrices of the unit cell forms a set of equations for the overall elastic frequency response. The acoustic pressure in the fluids is expressed using a source boundary element method. Adding rigid reflecting end caps confines the air in the gap between panels which influences sound transmission. Measured values of transmission loss differ from the 2-D model by the wide low-frequency dip of the mass-spring-mass or “msm” resonance also termed the “air gap resonance”. In this case, the panels act as rigid masses and the air gap acts as an adiabatic air spring. Results from the idealized 3-D and 2-D models, incorporating rigid cavities and elastic plates, reveal that the “msm” dip is absent in 2-D models radiating into a semi-infinite medium. The dip strengthens as aspect ratio approaches unity. Even when the dip disappears in 2-D, TL rises more steeply for frequencies above the “msm” frequency.

  17. Role of duodenal mucosal nerve endings in the acid-induced duodenogastric sensorimotor reflex: effect of benzocaine in healthy humans.

    Vanuytsel, T; Karamanolis, G; Vos, R; Van Oudenhove, L; Farré, R; Tack, J

    2013-05-01

    Duodenal acid exposure induces a duodenogastric reflex resulting in gastric relaxation, inhibition of antral motility, and sensitization of the proximal stomach to distension. Duodenal hypersensitivity to acid has been identified as a potential pathogenic mechanism in functional dyspepsia. The nature and localization of the duodenal acid-sensitive receptors are still elusive. We hypothesize that acid directly activates superficial afferent nerve endings in the duodenal mucosa, triggering the duodenogastric reflex. In a double-blind, randomized, crossover study in 13 healthy volunteers, benzocaine, a local anesthetic, vs saline was perfused in the duodenum 15 min before duodenal acid perfusion. Gastric responses were monitored by a barostat. Stepwise isobaric gastric distensions were performed before and during acid perfusion. Symptoms were evaluated by visual analogue scales for six dyspeptic symptoms and an overall perception score. Benzocaine perfusion caused a relaxation of the stomach prior to duodenal acidification, indicating the existence of an excitatory duodenogastric tone. Pretreatment of the duodenum with benzocaine reduced the acid-induced gastric relaxation by 50% and abolished the inhibition of phasic motility of the proximal stomach. Finally, sensitization to distension was more pronounced in the benzocaine condition because of higher proximal gastric volumes. These findings support a model in which different neuronal subpopulations are responsible for the motor and sensory limb of the acid-sensitive duodenogastric reflex, making benzocaine an unsuitable drug to treat duodenal hypersensitivity to acid. These data provide more insight in the contribution of duodenal neuronal input to gastric physiology in the fasting state. © 2013 Blackwell Publishing Ltd.

  18. The effect of regular hemodialysis on the nutritional status of children with end-stage renal disease

    Hala M Lotfy

    2015-01-01

    Full Text Available Growth failure is one of the most common and profound clinical manifestation of chronic kidney disease (CKD in infants, children and adolescents. The aim of this study was to assess the nutritional status of Egyptian children with end-stage renal disease (ESRD on regular hemodialysis (HD. The study included 50 Egyptian children with ESRD on regular HD, following-up at the Pediatric Nephrology unit, Cairo University. History, including dietary history, was taken for all patients and clinical examination was performed on all of them. Body weight, standing height, height or length SD score, the skin fold thickness, mid-arm circumference, mid-arm muscle circumference and mid-arm muscle circumference area were also assessed. The height of the patients was the most affected anthropometric parameter, as 78% of the patients were shorter (height SDS below -3. Body weight is less affected than height, as body weight SDS of 34% of patients was less than -3 SDS. In addition, the body mass index of 16% of the patients was 97 th percentile. Although most ESRD patients received adequate protein and caloric intake, their growth was markedly affected, especially with longer period on HD. We suggest that assessment of growth parameters should be performed at a minimum period of every six months in children with CKD stages 2-3. For children with more advanced CKD (stages 4-5 and 5D, more frequent evaluation may be warranted due to the greater risk of abnormalities.

  19. Skeletal, dental and profilometric effects of Sabbagh Universal Spring 2 (SUS2 in a patient at the end of growth: a case report

    Marchionni, P.

    2016-04-01

    Full Text Available Introduction: Malocclusions, which present a severe skeletal component, are difficult to solve through orthodontic treatment inpatients at the end of growth and often require a combined orthodontic-surgical treatment. The mandibular propulsion appliances "no compliance" now offer new possibilities for functional orthopedic treatment in borderline cases. Case presentation: A patient at the end of growth with a severe malocclusion (Class II Division 1, open bite with arches' transversaldiscrepancy, refused the hypothesis of an orthodontic-surgical treatment, which represents the gold standard in such occlusal andskeletal problems, especially in subjects at the end of growth; consequently, a complex orthopedic-orthodontic treatment was chosen as the second choice. The patient has been successfully treated also through the use of SUS2 (Sabbagh Universal Spring 2; Dentaurum, Ispringen, Germany, a "no compliance" fixed functional appliance, which carried out a significant sagittal correction. Conclusion: The case report especially highlights the important sagittal correction obtained through the use of SUS2. The SUS2 had a functional outcome, which resulted in the maxillary growth stop and an effective sagittal mandibular growth increase. The SUS2effects, enhanced by elastics biomechanics, led to the bite closure and at the achievement of Class I occlusion.

  20. Effects on Vocal Fold Collision and Phonation Threshold Pressure of Resonance Tube Phonation with Tube End in Water

    Enflo, Laura; Sundberg, Johan; Romedahl, Camilla; McAllister, Anita

    2013-01-01

    Purpose: Resonance tube phonation in water (RTPW) or in air is a voice therapy method successfully used for treatment of several voice pathologies. Its effect on the voice has not been thoroughly studied. This investigation analyzes the effects of RTPW on collision and phonation threshold pressures (CTP and PTP), the lowest subglottal pressure…

  1. The Differential Effects of Internship Participation on End-of-Fourth-Year GPA by Demographic and Institutional Characteristics

    Parker, Eugene T., III.; Kilgo, Cindy A.; Sheets, Jessica K. Ezell; Pascarella, Ernest T.

    2016-01-01

    The purpose of this study is to explore the effects of internship participation on college students, specifically the effect on college GPA. Further, because of the capacity to disaggregate students by race in the sample, this study is significant because it provides much needed empirical evidence surrounding the impact of participation in…

  2. Effects of Prolyl Hydroxylase Inhibitor L-mimosine on Dental Pulp in the Presence of Advanced Glycation End Products.

    Müller, Heinz-Dieter; Cvikl, Barbara; Janjić, Klara; Nürnberger, Sylvia; Moritz, Andreas; Gruber, Reinhard; Agis, Hermann

    2015-11-01

    Proangiogenic prolyl hydroxylase (PHD) inhibitors represent a novel approach to stimulate tissue regeneration. Diabetes mellitus involves the accumulation of advanced glycation end products (AGEs). Here we evaluated the impact of AGEs on the response of human pulp tissue to the PHD inhibitor L-mimosine (L-MIM) in monolayer cultures of dental pulp-derived cells (DPCs) and tooth slice organ cultures. In monolayer cultures, DPCs were incubated with L-MIM and AGEs. Viability was assessed based on formazan formation, live-dead staining, annexin V/propidium iodide, and trypan blue exclusion assay. Vascular endothelial growth factor (VEGF), interleukin (IL)-6, and IL-8 production was evaluated by quantitative polymerase chain reaction and immunoassays. Furthermore, expression levels of odontoblast markers were assessed, and alizarin red staining was performed. Tooth slice organ cultures were performed, and VEGF, IL-6, and IL8 levels in their supernatants were measured by immunoassays. Pulp tissue vitality and morphology were assessed by MTT assay and histology. In monolayer cultures of DPCs, L-MIM at nontoxic concentrations increased the production of VEGF and IL-8 in the presence of AGEs. Stimulation with L-MIM decreased alkaline phosphatase levels and matrix mineralization also in the presence of AGEs, whereas no significant changes in dentin matrix protein 1 and dentin sialophosphoprotein expression were observed. In tooth slice organ cultures, L-MIM increased VEGF but not IL-6 and IL-8 production in the presence of AGEs. The pulp tissue was vital, and no signs of apoptosis or necrosis were observed. Overall, in the presence of AGEs, L-MIM increases the proangiogenic capacity, but decreases alkaline phosphatase expression and matrix mineralization. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  3. Lattice Boltzmann analysis of effect of heating location and Rayleigh number on natural convection in partially heated open ended cavity

    Gangawane, Krunal Madhukar; Bharti, Ram Prakash; Kumar, Surendra [Indian Institute of Technology Roorkee, Uttarakhand (India)

    2015-08-15

    Natural convection characteristics of a partially heated open ended square cavity have been investigated numerically by using an in-house computational flow solver based on the passive scalar thermal lattice Boltzmann method (PS-TLBM) with D2Q9 (two-dimensional and nine-velocity link) lattice model. The partial part of left wall of the cavity is heated isothermally at either of the three different (bottom, middle and top) locations for the fixed heating length as half of characteristic length (H/2) while the right wall is open to the ambient conditions. The other parts of the cavity are thermally isolated. In particular, the influences of partial heating locations and Rayleigh number (103≤ Ra≤106) in the laminar zone on the local and global natural convection characteristics (such as streamline, vorticity and isotherm contours; centerline variations of velocity and temperature; and local and average Nusselt numbers) have been presented and discussed for the fixed value of the Prandtl number (Pr=0.71). The streamline patterns show qualitatively similar nature for all the three heating cases and Rayleigh numbers, except the change in the recirculation zone which is found to be largest for middle heating case. Isotherm patterns are shifted towards a partially heated wall on increasing Rayleigh number and/or shifting of heating location from bottom to top. Both the local and average Nusselt numbers, as anticipated, shown proportional increase with Rayleigh number. The cavity with middle heating location shown higher heat transfer rate than that for the top and bottom heating cases. Finally, the functional dependence of the average Nusselt number on flow governing parameters is also presented as a closure relationship for the best possible utilization in engineering practices and design.

  4. Effects of sex on the incidence and prognosis of spinal meningiomas: a Surveillance, Epidemiology, and End Results study.

    Westwick, Harrison J; Shamji, Mohammed F

    2015-09-01

    Most spinal meningiomas are intradural lesions in the thoracic spine that present with both local pain and myelopathy. By using the large prospective Surveillance, Epidemiology, and End Results (SEER) database, the authors studied the incidence of spinal meningiomas and examined demographic and treatment factors predictive of death. Using SEER*Stat software, the authors queried the SEER database for cases of spinal meningioma between 2000 and 2010. From the results, tumor incidence and demographic statistics were computed; incidence was analyzed as a function of tumor location, pathology, age, sex, and malignancy code. Survival was analyzed by using a Cox proportional hazards ratio in SPSS for age, sex, marital status, primary site, size quartile, treatment modality, and malignancy code. In this analysis, significance was set at a p value of 0.05. The 1709 spinal meningiomas reported in the SEER database represented 30.7% of all primary intradural spinal tumors and 7.9% of all meningiomas. These meningiomas occurred at an age-adjusted incidence of 0.193 (95% CI 0.183-0.202) per 100,000 population and were closely related to sex (337 [19.7%] male patients and 1372 [80.3%] female patients). The Cox hazard function for mortality in males was higher (2.4 [95% CI1.7-3.5]) and statistically significant, despite the lower lesion incidence in males. All-cause survival was lowest in patients older than 80 years. Primary site and treatment modality were not significant predictors of mortality. Spinal meningiomas represent a significant fraction of all primary intradural spinal tumors and of all meningiomas. The results of this study establish the association of lesion incidence and survival with sex, with a less frequent incidence in but greater mortality among males.

  5. A Study on the Effect of the Contact Point and the Contact Force of a Glass Fiber under End-Face Polishing Process

    Ying-Chien Tsai

    2015-01-01

    Full Text Available The offset between the center lines of the polished end-face and the fiber core has a significant effect on coupling efficiency. The initial contact point and the contact force are two of the most important parameters that induce the offset. This study proposes an image assistant method to find the initial contact point and a mathematical model to estimate the contact force when fabricating the double-variable-curvature end-face of single mode glass fiber. The repeatability of finding the initial contact point via the vision assistant program is 0.3 μm. Based on the assumption of a large deflection, a mathematical model is developed to study the relationship between the contact force and the displacement of the lapping film. In order to verify the feasibility of the mathematical model, experiments, as well as DEFORM simulations, are carried out. The results show that the contact forces are alomst linearly proportional to the feed amounts of the lapping film and the errors are less than 9%. By using the method developed in this study, the offset between the grinding end-face and the center line of the fiber core is within 0.15 to 0.35 μm.

  6. Beam quality improvement by population-dynamic-coupled combined guiding effect in end-pumped Nd:YVO4 laser oscillator

    Shen, Yijie; Gong, Mali; Fu, Xing

    2018-05-01

    Beam quality improvement with pump power increasing in an end-pumped laser oscillator is experimentally realized for the first time, to the best of our knowledge. The phenomenon is caused by the population-dynamic-coupled combined guiding effect, a comprehensive theoretical model of which has been well established, in agreement with the experimental results. Based on an 888 nm in-band dual-end-pumped oscillator using four tandem Nd:YVO4 crystals, the output beam quality of M^2= 1.1/1.1 at the pump power of 25 W is degraded to M^2 = 2.5/1.8 at 75 W pumping and then improved to M^2= 1.8/1.3 at 150 W pumping. The near-TEM_{00} mode is obtained with the highest continuous-wave output power of 72.1 W and the optical-to-optical efficiency of 48.1%. This work demonstrates great potential to further scale the output power of end-pumped laser oscillator while keeping good beam quality.

  7. Fuel rod end plug

    McGeary, R.K.; Bucher, G.D.

    1989-01-01

    This patent describes an end plug for welded disposition within the end of a tube. It comprises a circumferentially extending, axially oriented land surface, having a radial extent defined by means of a first predetermined dimension, for disposition within the end of the tube; a circumferentially extending, axially oriented land surface, having a radial extent defined by means of a second predetermined dimension which is greater than the first predetermined dimension, for disposition outside of the end of the tube. The second land surface being disposed upstream of the first land surface; an annularly extending, radially oriented shoulder portion, defined at the downstream end of the second land surface and having a radially inward depth which is greater than the difference defined between the first and second radial dimensions of the first and second land surfaces, for engaging the end of the tube in a butt contact fashion; and annular groove means defined between the upstream end of the first land surface and the shoulder portion of the end plug, for eliminating porosity defects normally developed within a weldment defined between the tube end and the end plug when the end plug is welded within the tube end, and including a conical surface which extends radially outwardly from the innermost radial depth extent of the shoulder portion to the upstream end of the first land surface

  8. Can specially trained community care workers effectively support patients and their families in the home setting at the end of life?

    Poulos, Roslyn G; Harkin, Damian; Poulos, Christopher J; Cole, Andrew; MacLeod, Rod

    2018-03-01

    Surveys indicate that many Australians would prefer to die at home, but relatively few do. Recognising that patients and their families may not have the support they need to enable end-of-life care at home, a consortium of care providers developed, and received funding to trial, the Palliative Care Home Support Program (PCHSP) across seven health districts in New South Wales, Australia. The programme aimed to supplement end-of-life care in the home provided by existing multidisciplinary community palliative care teams, with specialist supportive community care workers (CCWs). An evaluation of the service was undertaken, focussing on the self-reported impact of the service on family carers (FCs), with triangulation of findings from community palliative care teams and CCWs. Service evaluation data were obtained through postal surveys and/or qualitative interviews with FCs, community palliative care teams and CCWs. FCs also reported the experience of their loved one based on 10 items drawn from the Quality of Death and Dying Questionnaire (QODD). Thematic analysis of surveys and interviews found that the support provided by CCWs was valued by FCs for: enabling choice (i.e. to realise end-of-life care in the home); providing practical assistance ("hands-on"); and for emotional support and reassurance. This was corroborated by community palliative care teams and CCWs. Responses by FCs on the QODD items indicated that in the last week of life, effective control of symptoms was occurring and quality of life was being maintained. This study suggests that satisfactory outcomes for patients and their families who wish to have end-of-life care in the home can be enabled with the additional support of specially trained CCWs. A notable benefit of the PCHSP model, which provided specific palliative care vocational training to an existing community care workforce, was a relatively rapid increase in the palliative care workforce across the state. © 2017 John Wiley & Sons Ltd.

  9. Surfactant impairment after mechanical ventilation with large alveolar surface area changes and effects of positive end-expiratory pressure

    S.J.C. Verbrugge (Serge); S.H. Bohm; D.A.M.P.J. Gommers (Diederik); L.J.I. Zimmermann (Luc); B.F. Lachmann (Burkhard)

    1998-01-01

    textabstractWe have assessed the effects of overinflation on surfactant function and composition in rats undergoing ventilation for 20 min with 100% oxygen at a peak inspiratory pressure of 45 cm H2O, with or without PEEP 10 cm H2O (groups 45/10 and 45/0, respectively).

  10. A problem-solving approach to effective insulin injection for patients at either end of the body mass index.

    Juip, Micki; Fitzner, Karen

    2012-06-01

    People with diabetes require skills and knowledge to adhere to medication regimens and self-manage this complex disease. Effective self-management is contingent upon effective problem solving and decision making. Gaps existed regarding useful approaches to problem solving by individuals with very low and very high body mass index (BMI) who self-administer insulin injections. This article addresses those gaps by presenting findings from a patient survey, a symposium on the topic of problem solving, and recent interviews with diabetes educators to facilitate problem-solving approaches for people with diabetes with high and low BMI who inject insulin and/or other medications. In practice, problem solving involves problem identification, definition, and specification; goal and barrier identification are a prelude to generating a set of potential strategies for problem resolution and applying these strategies to implement a solution. Teaching techniques, such as site rotation and ensuring that people with diabetes use the appropriate equipment, increase confidence with medication adherence. Medication taking is more effective when people with diabetes are equipped with the knowledge, skills, and problem-solving behaviors to effectively self-manage their injections.

  11. Effects of the pneumoperitoneum and Trendelenburg position on respiratory mechanics in the rats by the end-inflation occlusion method

    Alessandro Rubini

    2012-01-01

    Conclusion: The cranial displacement of the diaphgram occurring as a consequence of Pnp and/or Tnd, for example during laparoscopic surgical procedures, causes an increment of respiratory system elastance and viscoelastic resistance. The analysis of addictive effects show that these are more likely to occur when Pnp + Tnd are compared to isolated Tnd rather than to isolated Pnp.

  12. Study on the effects of the regulating energy levy for businesses. State of the art at the end of 1997

    Bode, J.W.; Worrell, E.; Berkhout, P.H.G.; Giesberger, D.; Paape, A.H.; Velthuijsen, J.W.

    1998-05-01

    January 1, 1996, the so-called regulating energy levy (REB, abbreviated in Dutch and also known as ecotax or small-scale consumer levy ('kleinverbruikersheffing')) came into effect in the Netherlands. The Second chamber of the Dutch parliament requested an annual report of the effects of the REB. A first report was published in the summer of 1997. It appeared that for subsequent years a more elaborated survey is needed for which more research is required. In this report the results of a study on the role of the REB on energy conservation investment decisions, taken in several businesses (retail trade, the hotel and restaurant sector (horeca in Dutch), offices in the services sector, small businesses in the metals industry, and installers of energy saving installations),are presented 31 refs

  13. End of Life Issues

    Planning for the end of life can be difficult. But by deciding what end-of-life care best suits your needs when you are healthy, you can ... right choices when the time comes. End-of-life planning usually includes making choices about the following: ...

  14. Effect of stereotactic dosimetric end points on overall survival for Stage I non–small cell lung cancer: A critical review

    Mulryan, Kathryn; Leech, Michelle; Forde, Elizabeth, E-mail: eforde@tcd.ie

    2015-01-01

    Stereotactic body radiation therapy (SBRT) delivers a high biologically effective dose while minimizing toxicities to surrounding tissues. Within the scope of clinical trials and local practice, there are inconsistencies in dosimetrics used to evaluate plan quality. The purpose of this critical review was to determine if dosimetric parameters used in SBRT plans have an effect on local control (LC), overall survival (OS), and toxicities. A database of relevant trials investigating SBRT for patients with early-stage non–small cell lung cancer was compiled, and a table of dosimetric variables used was created. These parameters were compared and contrasted for LC, OS, and toxicities. Dosimetric end points appear to have no effect on OS or LC. Incidences of rib fractures correlate with a lack of dose-volume constraints (DVCs) reported. This review highlights the great disparity present in clinical trials reporting dosimetrics, DVCs, and toxicities for lung SBRT. Further evidence is required before standard DVCs guidelines can be introduced. Dosimetric end points specific to stereotactic treatment planning have been proposed but require further investigation before clinical implementation.

  15. Extreme value paradigm for the effect of size of target volume on end results in radiation oncology

    Herbert, D.E.

    1983-01-01

    In clinical radiation oncology, it is commonly reported that complications of normal tissue occur more readily at larger field sizes for a given dose and recurrence of disease is observed more frequently from the larger tumors for a given dose. Cognate phenomena have long been observed in the study of the strength of materials. That is, the larger specimens will fracture under less applied stress, breakdown under less applied voltage, corrode in a shorter time, etc. The statistical theory of extreme values has provided both a rational explanation and a technique for exploitation of these ''size effects'' on the likelihood of specimen failure. This theory describes the relation which exists between the parameters (in particular, the location parameter) of the frequency distributions of the extreme values [smallest x(1) and largest x(n)] in a sample from a population of observations xi and the sample size n. It is shown in the present paper that the clinical failure phenomena are not inconsistent with the statistical theory of extreme values. The paper presents heuristic comparisons of the predictions of this theory with the received clinical observations of the effect of the size of the volume of irradiated tissues on the likelihood of occurrence of the misadventures of clinical radiation oncology: recurrence of disease and complication of normal tissue. The concordance of observations and predictions is acceptable. The quality and quantity of the currently available data have precluded the construction of any apodictic representations

  16. Effects of intravenous home dobutamine in palliative end-stage heart failure on quality of life, heart failure hospitalization, and cost expenditure.

    Martens, Pieter; Vercammen, Jan; Ceyssens, Wendy; Jacobs, Linda; Luwel, Evert; Van Aerde, Herwig; Potargent, Peter; Renaers, Monique; Dupont, Matthias; Mullens, Wilfried

    2018-01-17

    In patients with palliative end-stage heart failure, interventions that could provide symptomatic relief and prevent hospital admissions are important. Ambulatory continuous intravenous inotropes have been advocated by guidelines for such a purpose. We sought to determine the effect of intravenous dobutamine on symptomatic status, hospital stay, mortality, and cost expenditure. All consecutive end-stage heart failure patients not amenable for advanced therapies and discharged with continuous intravenous home dobutamine from a single tertiary centre between April 2011 and January 2017 were retrospectively analysed. Dobutamine (fixed dose) was infused through a single-lumen central venous catheter with a small pump that was refilled by a nurse on a daily basis. Symptomatic status was longitudinally assessed as the change in New York Heart Association class and patient global assessment scale. Antecedent and incident heart failure hospitalizations were determined in a paired fashion, and cost impact was assessed. A total of 21 patients (age 77 ± 9 years) were followed up for 869 ± 647 days. At first follow-up (6 ± 1 weeks) after the initiation of dobutamine, patients had a significant improvement in New York Heart Association class (-1.29 ± 0.64; P heart failure hospitalizations assessed at 3, 6, and 12 months were significantly reduced (P heart failure hospitalizations over the same time period. Cost expenditure was significantly lower at 3 (P heart failure is feasible and associated with improved symptomatic status, heart failure hospitalizations, and health-care-related costs. Nevertheless, results should be interpreted in the context of the small and retrospective design. Larger studies are necessary to evaluate the effect of dobutamine in palliative end-stage heart failure. © 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

  17. Cellular and molecular effects of natural background radiation on human population in Kerala coast, India: from chromosome ends to transcriptome

    Das, Birajalaxmi; Jain, Vinay; Saini, Divyalakshmi; Ghosh, Anu; Seshadri, M. [Radiation Biology and Health Sciences Division, Bio-Medical Group, Bhabha Atomic Research Centre, Mumbai (India); Sandhya Kiran, P. [Ocimum Biosolutions India Limited, Hyderabad (India)

    2010-07-01

    Venous blood samples of 32 male volunteers (age group 35-45 years) from different background dose groups. Factors like life style, smoking, drinking alcohol, chewing, previous exposure to radiation and medical history etc. were properly recorded. Microarray analysis was performed using Affymetrix FlGU133 plus 2.0 chip and the expression level of 54,675 genes were obtained for each sample. In order to assess the effect of chronic natural background radiation we have categorized our samples into four groups. To derive genes that are differentially regulated between these four groups, 'Exposed group versus Control' was set up and the linear model was fitted to each gene using the expression data on samples. A fold change threshold of 1.3, 1.5 and 2.0 and an adjusted p-value threshold of 0.05 was set in the study. Analysis was done using 'limma' library of R and Genowiz.

  18. Direct Enzymatic Branch-End Extension of Glycocluster-Presented Glycans: An Effective Strategy for Programming Glycan Bioactivity.

    Bayón, Carlos; He, Ning; Deir-Kaspar, Mario; Blasco, Pilar; André, Sabine; Gabius, Hans-Joachim; Rumbero, Ángel; Jiménez-Barbero, Jesús; Fessner, Wolf-Dieter; Hernáiz, María J

    2017-01-31

    The sequence of a glycan and its topology of presentation team up to determine the specificity and selectivity of recognition by saccharide receptors (lectins). Structure-activity analysis would be furthered if the glycan part of a glycocluster could be efficiently elaborated in situ while keeping all other parameters constant. By using a bacterial α2,6-sialyltransferase and a small library of bi- to tetravalent glycoclusters, we illustrate the complete conversion of scaffold-presented lactoside units into two different sialylated ligands based on N-acetyl/glycolyl-neuraminic acid incorporation. We assess the ensuing effect on their bioactivity for a plant toxin, and present an analysis of the noncovalent substrate binding contacts that the added sialic acid moiety makes to the lectin. Enzymatic diversification of a scaffold-presented glycan can thus be brought to completion in situ, offering a versatile perspective for rational glycocluster engineering. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Cellular and molecular effects of natural background radiation on human population in Kerala coast, India: from chromosome ends to transcriptome

    Das, Birajalaxmi; Jain, Vinay; Saini, Divyalakshmi; Ghosh, Anu; Seshadri, M.; Sandhya Kiran, P.

    2010-01-01

    Venous blood samples of 32 male volunteers (age group 35-45 years) from different background dose groups. Factors like life style, smoking, drinking alcohol, chewing, previous exposure to radiation and medical history etc. were properly recorded. Microarray analysis was performed using Affymetrix FlGU133 plus 2.0 chip and the expression level of 54,675 genes were obtained for each sample. In order to assess the effect of chronic natural background radiation we have categorized our samples into four groups. To derive genes that are differentially regulated between these four groups, 'Exposed group versus Control' was set up and the linear model was fitted to each gene using the expression data on samples. A fold change threshold of 1.3, 1.5 and 2.0 and an adjusted p-value threshold of 0.05 was set in the study. Analysis was done using 'limma' library of R and Genowiz

  20. Open-ended education

    Nørgård, Rikke Toft; Paaskesen, Rikke Berggreen

    2016-01-01

    THE ARTICLE DESCRIBES OPEN-ENDED EDUCATION FOR 21ST CENTURY LEARNING AS THE COMING TOGETHER OF OPEN-ENDED TECHNOLOGY, OPEN-ENDED PROJECTS, AND OPEN-ENDED INSTITUTIONS IN WAYS THAT FOSTER AND PROMOTE FUTURE EDUCATION FOR CITIZENSHIP IN SOCIETY. THROUGH THE CASE OF THE CODING PIRATES FUTURE ISLAND......, THE ARTICLE DEMONSTRATES HOW OPEN-ENDED EDUCATION CAN BE PRACTICED TO FOSTER AND PROMOTE TECHNOLOGICAL IMAGINATION, ENTERPRISING, AND PARTICIPATION. THIS PRACTICE IS THEN DEVELOPED INTO A THEORETICAL MODEL FOR THE CONCEPT OF OPEN-ENDED EDUCATION AS A WAY OF AND FRAMEWORK FOR PRACTICING FUTURE EDUCATION FOR 21......ST CENTURY LEARNING WITH NEW TECHNOLOGIES. THE ARTICLE PRESENTS AN ANSWER TO THE CALL FOR 21ST CENTURY LEARNING AS THOROUGHLY COLLABORATIVE, COMMUNICATIVE, CREATIVE, AND CRITICALLY REFLECTIVE THROUGH THE CASE AND THE CONCEPT OF OPEN-ENDED EDUCATION. IT OUTLINES THE IMPLICATIONS OF THIS CALL...

  1. Effect of cephalandra indica against advanced glycation end products, sorbitol accumulation and aldose reductase activity in homoeopathic formulation

    Lalit Kishore

    2018-01-01

    Full Text Available Background: Extreme generation of free radicals leads to oxidative stress which has been apprehensive in several disease processes such as diabetic complications and vascular and neurodegenerative diseases. Objective: The present study was designed to evaluate the potential of homoeopathic preparations of Cephalandra indica L. against oxidative stress. Materials and Methods: Potencies of Cephalandra indica (mother tincture, 6C and 30C were procured from Dr. Willmar Schwabe India Pvt. Ltd. The antioxidant activity of Cephalandra indica was evaluated by employing various in vitro antioxidant methods. Results: The total phenol content was found to be 1905, 849 and 495 mg/g gallic acid equivalents in mother tincture, 6C and 30C of Cephalandra indica and total antioxidant capacity was found to be 2710, 759 and 510 μM/g ascorbic acid equivalents, respectively. Mother tincture, 6C and 30C of Cephalandra indica was found to have strong reducing power, 2,2-diphenyl-1-picrylhydrazyl radical, hydrogen peroxide, nitric oxide and superoxide radical scavenging activity. Percentage inhibition of AGEs formation by mother tincture, 6C and 30C of Cephalandra indica (10–50 μl was found to be 30.34%–91.77%, 29.98%–65.71% and 33.05%–57.75%, respectively. Mother tincture, 6C and 30C of Cephalandra indica showed inhibitory effect against sorbitol accumulation with IC50value of 26.12 μl, 203.10 μl and 897.3 μl, respectively, whereas, in aldose reductase inhibition assay, the IC50value was 32.54 μl, 175.02 μl and 834.34 μl, respectively. Conclusion: The results revealed that homoeopathic preparations of Cephalandra indica exhibit protective effect against oxidative stress.

  2. Study on Effect of Ultrasonic Vibration on Grinding Force and Surface Quality in Ultrasonic Assisted Micro End Grinding of Silica Glass

    Zhang Jianhua

    2014-01-01

    Full Text Available Ultrasonic vibration assisted micro end grinding (UAMEG is a promising processing method for micro parts made of hard and brittle materials. First, the influence of ultrasonic assistance on the mechanism of this processing technology is theoretically analyzed. Then, in order to reveal the effects of ultrasonic vibration and grinding parameters on grinding forces and surface quality, contrast grinding tests of silica glass with and without ultrasonic assistance using micro radial electroplated diamond wheel are conducted. The grinding forces are measured using a three-component dynamometer. The surface characteristics are detected using the scanning electron microscope. The experiment results demonstrate that grinding forces are significantly reduced by introducing ultrasonic vibration into conventional micro end grinding (CMEG of silica glass; ultrasonic assistance causes inhibiting effect on variation percentages of tangential grinding force with grinding parameters; ductile machining is easier to be achieved and surface quality is obviously improved due to ultrasonic assistance in UAMEG. Therefore, larger grinding depth and feed rate adopted in UAMEG can lead to the improvement of removal rate and machining efficiency compared with CMEG.

  3. Effects of Low-Carbon Technologies and End-Use Electrification on Energy-Related Greenhouse Gases Mitigation in China by 2050

    Zheng Guo

    2015-07-01

    Full Text Available Greenhouse gas emissions in China have been increasing in line with its energy consumption and economic growth. Major means for energy-related greenhouse gases mitigation in the foreseeable future are transition to less carbon intensive energy supplies and structural changes in energy consumption. In this paper, a bottom-up model is built to examine typical projected scenarios for energy supply and demand, with which trends of energy-related carbon dioxide emissions by 2050 can be analyzed. Results show that low-carbon technologies remain essential contributors to reducing emissions and altering emissions trends up to 2050. By pushing the limit of current practicality, emissions reduction can reach 20 to 28 percent and the advent of carbon peaking could shift from 2040 to 2030. In addition, the effect of electrification at end-use sectors is studied. Results show that electrifying transport could reduce emissions and bring the advent of carbon peaking forward, but the effect is less significant compared with low-carbon technologies. Moreover, it implies the importance of decarbonizing power supply before electrifying end-use sectors.

  4. Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats.

    Lee, Bao-Hong; Hsu, Wei-Hsuan; Huang, Tao; Chang, Yu-Ying; Hsu, Ya-Wen; Pan, Tzu-Ming

    2013-02-13

    Hyperglycemia is associated with advanced glycation end products (AGEs). This study was designed to evaluate the inhibitory effects of monascin on receptor for advanced glycation end product (RAGE) signal and THP-1 monocyte inflammation after treatment with S100b, a specific ligand of RAGE. Monascin inhibited cytokine production by S100b-treated THP-1 monocytes via up-regulation of nuclear factor-erythroid 2-related factor-2 (Nrf2) and alleviated p47phox translocation to the membrane. Methylglyoxal (MG, 600 mg/kg bw) was used to induce diabetes in Wistar rats. Inhibitions of RAGE and p47phox by monascin were confirmed by peripheral blood mononuclear cells (PBMCs) of MG-induced rats. Silymarin (SM) was used as a positive control group. It was found that monascin promoted heme oxygenase-1 (HO-1) expression mediated by Nrf2. Suppressions of AGEs, tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-β) in serum of MG-induced rats were attenuated in the monascin administration group treated with retinoic acid (RA). RA treatment resulted in Nrf2 inactivation by increasing RA receptor-α (RARα) activity, suggesting that RA acts as an inhibitor of Nrf2. The results showed that monascin exerted anti-inflammatory and antioxidative effects mediated by Nrf2 to prevent the development of diseases such as type 2 diabetes caused by inflammation.

  5. Assessing the Moderating Effect of the End User in Consumer Behavior: The Acceptance of Technological Implants to Increase Innate Human Capacities.

    Pelegrín-Borondo, Jorge; Reinares-Lara, Eva; Olarte-Pascual, Cristina; Garcia-Sierra, Marta

    2016-01-01

    Today, technological implants are being developed to increase innate human capacities, such as memory or calculation speed, and to endow us with new ones, such as the remote control of machines. This study's aim was two-fold: first, to introduce a Cognitive-Affective-Normative (CAN) model of technology acceptance to explain the intention to use this technology in the field of consumer behavior; and second, to analyze the differences in the intention to use it based on whether the intended implant recipient is oneself or one's child (i.e., the moderating effect of the end user). A multi-group analysis was performed to compare the results between the two groups: implant "for me" (Group 1) and implant "for my child" (Group 2). The model largely explains the intention to use the insideable technology for the specified groups [variance explained (R (2)) of over 0.70 in both cases]. The most important variables were found to be "positive emotions" and (positive) "subjective norm." This underscores the need to broaden the range of factors considered to be decisive in technology acceptance to include variables related to consumers' emotions. Moreover, statistically significant differences were found between the "for me" and "for my child" models for "perceived ease of use (PEU)" and "subjective norm." These findings confirm the moderating effect of the end user on new insideable technology acceptance.

  6. Assessing the moderating effect of the end user in consumer behavior: the acceptance of technological implants to increase innate human capacities

    Jorge ePelegrín-Borondo

    2016-02-01

    Full Text Available Today, technological implants are being developed to increase innate human capacities, such as memory or calculation speed, and to endow us with new ones, such as the remote control of machines. This study’s aim was twofold: first, to introduce a Cognitive-Affective-Normative model of technology acceptance to explain the intention to use this technology in the field of consumer behavior; and second, to analyze the differences in the intention to use it based on whether the intended implant recipient is oneself or one’s child (i.e., the moderating effect of the end user. A multi-group analysis was performed to compare the results between the two groups: implant for me (Group 1 and implant for my child (Group 2. The model largely explains the intention to use the insideable technology for the specified groups (variance explained (R2 of over 0.70 in both cases. The most important variables were found to be positive emotions and (positive subjective norm. This underscores the need to broaden the range of factors considered to be decisive in technology acceptance to include variables related to consumers’ emotions. Moreover, statistically significant differences were found between the for me and for my child models for perceived ease of use and subjective norm. These findings confirm the moderating effect of the end user on new insideable technology acceptance.

  7. Discussion about effecting of stiffener in four bolts in a row end plate connection for long span and heavy load steel structures in Vietnam

    Huong, Khang T.; Nguyen, Cung H.

    2018-04-01

    Nowadays, steel structure industry in Vietnam is in strong development. The construction of steel structure becomes larger span and heavier load. The issue spawned a number of issues arise from optimizing connections. Typical of steel connections in prefabricated steel structure that is an end plate (face plate) bolted connection. When the connection carried a heavy load, then the number of bolts is required much more. Increasing the number of rows bolts will less effective because can still not enough strength requirements, the bolts in row near rotational center will level arm reduction, then it cannot carry heavy loads. The current solution is doing multiple bolts in a row. Current standards such as EN [1], AISC [2] are no specific guidelines for calculating the connection four bolts in a row that primarily assumes the way works like a T-stub of the two bolts a row. Some articles studied T-stub four bolts in a row [3], [4], [5], [6] by component method but it has some components which weren’t considered. In this paper, in order to provide a contribution to improve the T-stub four bolts in a row, the stiffener component in T-stub will be added and compared with T-stub without stiffener by the finite element model to demonstrate effectiveness in reducing stress and displacement of T-stub. It gives ideas for the economic design of four bolts in a row end plate connection in Vietnam for future.

  8. Effect of workplace incivility on end-of-work negative affect: examining individual and organizational moderators in a daily diary study.

    Zhou, Zhiqing E; Yan, Yu; Che, Xin Xuan; Meier, Laurenz L

    2015-01-01

    Although previous studies have linked workplace incivility with various negative outcomes, they mainly focused on the long-term effects of chronic exposure to workplace incivility, whereas targets' short-term reactions to incivility episodes have been largely neglected. Using a daily diary design, the current study examined effects of daily workplace incivility on end-of-work negative affect and explored potential individual and organizational moderators. Data collected from 76 full-time employees across 10 consecutive working days revealed that daily workplace incivility positively predicted end-of-work negative affect while controlling for before-work negative affect. Further, the relationship was stronger for people with low emotional stability, high hostile attribution bias, external locus of control, and people experiencing low chronic workload and more chronic organizational constraints, as compared with people with high emotional stability, low hostile attribution bias, internal locus of control, and people experiencing high chronic workload and fewer chronic organizational constraints, respectively. (PsycINFO Database Record (c) 2014 APA, all rights reserved). PsycINFO Database Record (c) 2014 APA, all rights reserved.

  9. Effects of vehicle front-end stiffness on rear seat dummies in NCAP and FMVSS208 tests.

    Sahraei, Elham; Digges, Kennerly; Marzougui, Dhafer

    2013-01-01

    This study is devoted to quantifying changes in mass and stiffness of vehicles tested by the National Highway Traffic Safety Administration (NHTSA) over the past 3 decades (model years 1982 to 2010) and understanding the effect of those changes on protection of rear seat occupants. A total of 1179 tests were used, and the changes in their mass and stiffness versus their model year was quantified. Additionally, data from 439 dummies tested in rear seats of NHTSA's full frontal crashes were analyzed. Dummies were divided into 3 groups based on their reference injury criteria. Multiple regressions were performed with speed, stiffness, and mass as predicting variables for head, neck, and chest injury criteria. A significant increase in mass and stiffness over model year of vehicles was observed, for passenger cars as well as large platform vehicles. The result showed a significant correlation (P-value < .05) between the increase in stiffness of the vehicles and increase in head and chest injury criteria for all dummy sizes. These results explain that stiffness is a significant contributor to previously reported decreases in protection of rear seat occupants over model years of vehicles.

  10. Promoting End-of-Life Discussions in Advanced Cancer: Effects of Patient Coaching and Question Prompt Lists.

    Rodenbach, Rachel A; Brandes, Kim; Fiscella, Kevin; Kravitz, Richard L; Butow, Phyllis N; Walczak, Adam; Duberstein, Paul R; Sullivan, Peter; Hoh, Beth; Xing, Guibo; Plumb, Sandy; Epstein, Ronald M

    2017-03-10

    Purpose To build on results of a cluster randomized controlled trial (RCT) of a combined patient-oncologist intervention to improve communication in advanced cancer, we conducted a post hoc analysis of the patient intervention component, a previsit patient coaching session that used a question prompt list (QPL). We hypothesized that intervention-group participants would bring up more QPL-related topics, particularly prognosis-related topics, during the subsequent oncologist visit. Patients and Methods This cluster RCT with 170 patients who had advanced nonhematologic cancer (and their caregivers) recruited from practices of 24 participating oncologists in western New York. Intervention-group oncologists (n = 12) received individualized communication training; up to 10 of their patients (n = 84) received a previsit individualized communication coaching session that incorporated a QPL. Control-group oncologists (n = 12) and patients (n = 86) received no interventions. Topics of interest identified by patients during the coaching session were summarized from coaching notes; one office visit after the coaching session was audio recorded, transcribed, and analyzed by using linear regression modeling for group differences. Results Compared with controls, more than twice as many intervention-group participants brought up QPL-related topics during their office visits (70.2% v 32.6%; P coaching, 158 (60.3%) were QPL related; 20 (12.7%) addressed prognosis. Overall, patients in the intervention group brought up 82.4% of topics of interest during the office visit. Conclusion A combined coaching and QPL intervention was effective to help patients with advanced cancer and their caregivers identify and bring up topics of concern, including prognosis, during their subsequent oncologist visits. Considering that most patients are misinformed about prognosis, more intensive steps are needed to better promote such discussions.

  11. Effect of fentanyl and lidocaine on the end-tidal sevoflurane concentration preventing motor movement in dogs.

    Suarez, Martin A; Seddighi, Reza; Egger, Christine M; Rohrbach, Barton W; Cox, Sherry K; KuKanich, Butch K; Doherty, Thomas J

    2017-01-01

    OBJECTIVE To determine effects of fentanyl, lidocaine, and a fentanyl-lidocaine combination on the minimum alveolar concentration of sevoflurane preventing motor movement (MAC NM ) in dogs. ANIMALS 6 adult Beagles. PROCEDURES Dogs were anesthetized with sevoflurane in oxygen 3 times (1-week intervals). Baseline MAC NM (MAC NM-B ) was determined starting 45 minutes after induction of anesthesia. Dogs then received 1 of 3 treatments IV: fentanyl (loading dose, 15 μg/kg; constant rate infusion [CRI], 6 μg/kg/h), lidocaine (loading dose, 2 mg/kg; CRI, 6 mg/kg/h), and the fentanyl-lidocaine combination at the same doses. Determination of treatment MAC NM (MAC NM-T ) was initiated 90 minutes after start of the CRI. Venous blood samples were collected at the time of each treatment MAC NM measurement for determination of plasma concentrations of fentanyl and lidocaine. RESULTS Mean ± SEM overall MAC NM-B for the 3 treatments was 2.70 ± 0.27 vol%. The MAC NM decreased from MAC NM-B to MAC NM-T by 39%, 21%, and 55% for fentanyl, lidocaine, and the fentanyl-lidocaine combination, respectively. This decrease differed significantly among treatments. Plasma fentanyl concentration was 3.25 and 2.94 ng/mL for fentanyl and the fentanyl-lidocaine combination, respectively. Plasma lidocaine concentration was 2,570 and 2,417 ng/mL for lidocaine and the fentanyl-lidocaine combination, respectively. Plasma fentanyl and lidocaine concentrations did not differ significantly between fentanyl and the fentanyl-lidocaine combination or between lidocaine and the fentanyl-lidocaine combination. CONCLUSIONS AND CLINICAL RELEVANCE CRIs of fentanyl, lidocaine, and the fentanyl-lidocaine combination at the doses used were associated with clinically important and significant decreases in the MAC NM of sevoflurane in dogs.

  12. End region and current consolidation effects upon the performance of an MHD channel for the ETF conceptual design. [Engineering Test Facility

    Wang, S. Y.; Smith, J. M.

    1982-01-01

    It is noted that operating conditions which yielded a peak thermodynamic efficiency (41%) for an EFT-size MHD/steam power plant were previously (Wang et al., 1981; Staiger, 1981) identified by considering only the active region (the primary portion for power production) of an MHD channel. These previous efforts are extended here to include an investigation of the effects of the channel end regions on overall power generation. Considering these effects, the peak plant thermodynamic efficiency is found to be slightly lowered (40.7%); the channel operating point for peak efficiency is shifted to the supersonic mode (Mach number of approximately 1.1) rather than the previous subsonic operation (Mach number of approximately 0.9). Also discussed is the sensitivity of the channel performance to the B-field, diffuser recovery coefficient, channel load parameter, Mach number, and combustor pressure.

  13. The Effects of Teacher and Teacher-librarian High-end Collaboration on Inquiry-based Project Reports and School Monthly Test Scores of Fifth-grade Students

    Hai-Hon Chen

    2015-07-01

    Full Text Available The purpose of this study was twofold. The first purpose was to establish the high level collaboration of integrated instruction model between social studies teacher and teacher-librarian. The second purpose was to investigate the effects of high-end collaboration on the individual and groups’ inquiry-based project reports, as well as monthly test scores of fifth-grade students. A quasi-experimental method was adopted, two classes of elementary school fifth graders in Tainan Municipal city, Taiwan were used as samples. Students were randomly assigned to experimental conditions by class. Twenty eight students of the experimental group were taught by the collaboration of social studies teacher and teacher-librarian; while 27 students of the controlled group were taught separately by teacher in didactic teaching method. Inquiry-Based Project Record, Inquiry-Based Project Rubrics, and school monthly test scores were used as instruments for collecting data. A t-test and correlation were used to analyze the data. The results indicate that: (1 High-end collaboration model between social studies teacher and teacher-librarian was established and implemented well in the classroom. (2There was a significant difference between the experimental group and the controlled group in individual and groups’ inquiry-based project reports. Students that were taught by the collaborative teachers got both higher inquiry-based project reports’ scores than those that were taught separately by the teachers. Experimental group’s students got higher school monthly test scores than controlled groups. Suggestions for teachers’ high-end collaboration and future researcher are provided in this paper.

  14. The Effect of Reading Involvement through Open-Ended Strategy vs. Fill-in- the- Blanks Strategy on Young EFL Learners’ Reading Comprehension Ability

    Rita Salehi Sepehr

    2014-11-01

    Full Text Available The present study investigated the extent to which an instructional framework of integrating strategy instruction (open-ended strategy and fill-in-the blanks strategy with motivation- support affected on reading result for young EFL learners. The central area of exploration included a comparison among three approaches to reading instruction: First, fill-in-the blanks strategy intervention; second, open-ended strategy intervention; and last, a control group which received the conventional reading strategies. The participants were sampled from amongst a group of seventy-seven pre-intermediate EFL learners in a language school in Tehran- Iran based on convenient sampling technique. For the sake of measurement, the researchers administered PET and CELT along with reading strategy based-test to quantify the participants’ current level of knowledge as well as the degree of achievement after treatment. For measurement’s sake, different types of tests such as PET, reading comprehension test (CELT, and reading strategy based- test were employed to quantify the participants’ current level of knowledge as well as the degree of achievement before and after instruction. The result of the present study indicated that the experimental groups had a significant improvement over the control group. Also, the level of learners’ reading engagement during classroom work mediated the instructional effects on reading outcomes. The results of this study can be to the benefit of both EFL and ESL teachers to teach reading comprehension using the student's critical mind as well as critical involvement in the reading tasks.

  15. The effect of flexor tenotomy on healing and prevention of neuropathic diabetic foot ulcers on the distal end of the toe

    van Netten Jaap J

    2013-01-01

    Full Text Available Abstract Background Flexor tenotomy is a minimally invasive surgical alternative for the treatment of neuropathic diabetic foot ulcers on the distal end of the toe. The influence of infection on healing and time to heal after flexor tenotomy is unknown. Flexor tenotomy can also be used as a prophylactic treatment. The effectiveness as a prophylactic treatment has not been described before. Methods A retrospective study was performed with the inclusion of all consecutive flexor tenotomies from one hospital between January 2005 and December 2011. Results From 38 ulcers, 35 healed (92%, with a mean time to heal of 22 ± 26 days. The longest duration for healing was found for infected ulcers that were penetrating to bone (35 days; p = .042. Cases of prophylactic flexor tenotomies (n=9 did not result in any ulcer or other complications during follow-up. Conclusions The results of this study suggest that flexor tenotomy may be beneficial for neuropathic diabetic foot ulcers on the distal end of the toe, with a high healing percentage and a short mean time to heal. Infected ulcers that penetrated to bone took a significantly longer time to heal. Prospective research, to confirm the results of this retrospective study, should be performed.

  16. Effects of prescription depth, cylinder size, treatment length, tip space, and curved end on doses in high-dose-rate vaginal brachytherapy

    Li Shidong; Aref, Ibrahim; Walker, Eleanor; Movsas, Benjamin

    2007-01-01

    Purpose: To determine the effects of the prescription depth, cylinder size, treatment length, tip space, and curved end on high-dose-rate vaginal brachytherapy (HDR-VBT) of endometrial cancer. Methods and Materials: Treatment plans were prescribed and optimized based on points at the cylinder surface or at 0.5-cm depth. Cylinder sizes ranging from 2 to 4 cm in diameter, and treatment lengths ranging from 3 to 8 cm were used. Dose points in various depths were precisely defined along the cylinder dome. The given dose and dose uniformity to a depth of interest were measured by the mean dose (MD) and standard deviation (SD), respectively, among the dose points belonging to the depth. Dose fall-off beyond the 0.5 cm treatment depth was determined by the ratio of MD at 0.75-cm depth to MD at 0.5-cm depth. Results: Dose distribution varies significantly with different prescriptions. The surface prescription provides more uniform doses at all depths in the target volume, whereas the 0.5-cm depth prescription creates larger dose variations at the cylinder surface. Dosimetric uncertainty increases significantly (>30%) with shorter tip space. Extreme hot (>150%) and cold spots (<60%) occur if no optimization points were placed at the curved end. Conclusions: Instead of prescribing to a depth of 0.5 cm, increasing the dose per fraction and prescribing to the surface with the exact surface points around the cylinder dome appears to be the optimal approach

  17. GFR Decline as an Alternative End Point to Kidney Failure in Clinical Trials : A Meta-analysis of Treatment Effects From 37 Randomized Trials

    Inker, Lesley A.; Lambers Heerspink, Hiddo J.; Mondal, Hasi; Schmid, Christopher H.; Tighiouart, Hocine; Noubary, Farzad; Coresh, Josef; Greene, Tom; Levey, Andrew S.

    2014-01-01

    Background: There is increased interest in using alternative end points for trials of kidney disease progression. The currently established end points of end-stage renal disease and doubling of serum creatinine level, equivalent to a 57% decline in estimated glomerular filtration rate (eGFR), are

  18. Exposure to thin-ideal media affect most, but not all, women: Results from the Perceived Effects of Media Exposure Scale and open-ended responses.

    Frederick, David A; Daniels, Elizabeth A; Bates, Morgan E; Tylka, Tracy L

    2017-12-01

    Findings conflict as to whether thin-ideal media affect women's body satisfaction. Meta-analyses of experimental studies reveal small or null effects, but many women endorse appearance-related media pressure in surveys. Using a novel approach, two samples of women (Ns=656, 770) were exposed to bikini models, fashion models, or control conditions and reported the effects of the images their body image. Many women reported the fashion/bikini models made them feel worse about their stomachs (57%, 64%), weight (50%, 56%), waist (50%, 56%), overall appearance (50%, 56%), muscle tone (46%, 52%), legs (45%, 48%), thighs (40%, 49%), buttocks (40%, 43%), and hips (40%, 46%). In contrast, few women (1-6%) reported negative effects of control images. In open-ended responses, approximately one-third of women explicitly described negative media effects on their body image. Findings revealed that many women perceive negative effects of thin-ideal media in the immediate aftermath of exposures in experimental settings. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Effects of Different End-Point Cooking Temperatures on the Efficiency of Encapsulated Phosphates on Lipid Oxidation Inhibition in Ground Meat.

    Kılıç, B; Şimşek, A; Claus, J R; Atılgan, E; Aktaş, N

    2015-10-01

    Effects of 0.5% encapsulated (e) phosphates (sodium tripolyphosphate, STP; sodium hexametaphosphate, HMP; sodium pyrophosphate, SPP) on lipid oxidation during storage (0, 1, and 7 d) of ground meat (chicken, beef) after being cooked to 3 end-point cooking temperatures (EPCT; 71, 74, and 77 °C) were evaluated. The use of STP or eSTP resulted in lower (P cooking loss (CL) compared to encapsulated or unencapsulated forms of HMP and SPP. Increasing EPCT led to a significant increase in CL (P chicken compared to 74 and 71 °C (P chicken samples (P < 0.05). Findings suggest that encapsulated phosphates can be a strategy to inhibit lipid oxidation for meat industry and the efficiency of encapsulated phosphates on lipid oxidation inhibition can be enhanced by lowering EPCT. © 2015 Institute of Food Technologists®

  20. Perceived Effects of Pornography on the Couple Relationship: Initial Findings of Open-Ended, Participant-Informed, "Bottom-Up" Research.

    Kohut, Taylor; Fisher, William A; Campbell, Lorne

    2017-02-01

    The current study adopted a participant-informed, "bottom-up," qualitative approach to identifying perceived effects of pornography on the couple relationship. A large sample (N = 430) of men and women in heterosexual relationships in which pornography was used by at least one partner was recruited through online (e.g., Facebook, Twitter, etc.) and offline (e.g., newspapers, radio, etc.) sources. Participants responded to open-ended questions regarding perceived consequences of pornography use for each couple member and for their relationship in the context of an online survey. In the current sample of respondents, "no negative effects" was the most commonly reported impact of pornography use. Among remaining responses, positive perceived effects of pornography use on couple members and their relationship (e.g., improved sexual communication, more sexual experimentation, enhanced sexual comfort) were reported frequently; negative perceived effects of pornography (e.g., unrealistic expectations, decreased sexual interest in partner, increased insecurity) were also reported, albeit with considerably less frequency. The results of this work suggest new research directions that require more systematic attention.

  1. Investigation of the purging effect on a dead-end anode PEM fuel cell-powered vehicle during segments of a European driving cycle

    Gomez, Alberto; Sasmito, Agus P.; Shamim, Tariq

    2015-01-01

    Highlights: • Experimental study of a dead-end anode PEM fuel cell stack during a driving cycle. • Low purging duration is preferred at high current. • High purging frequency can sustain a better performance over time. • Lower cathode stoichiometry is preferred to minimize the parasitic loads. - Abstract: The dynamic performance of the PEM fuel cell is one of the key factors for successful operation of a fuel cell-powered vehicle. Maintaining fast time response while keeping stable and high stack performance is of importance, especially during acceleration and deceleration. In this paper, we evaluate the transient response of a PEM fuel cell stack with a dead-end anode during segments of a legislated European driving cycle together with the effect of purging factors. The PEM fuel cell stack comprises of 24 cells with a 300 cm"2 active catalyst area and operates at a low hydrogen and air pressure. Humidified air is supplied to the cathode side and the dry hydrogen is fed to the anode. The liquid coolant is circulated to the stack and the radiator to maintain the thermal envelope throughout the stack. The stack performance deterioration over time is prevented by utilizing the purging, which removes the accumulated water and impurities. The effect of purging period, purging duration, coolant flow rate and cathode stoichiometry are examined with regard to the fuel cell’s transient performance during the driving cycle. The results show that a low purging duration may avoid the undesired deceleration at a high current, and a high purging period may sustain a better performance over time. Moreover, the coolant flow rate is found to be an important parameter, which affects the stack temperature–time response of the cooling control and the stack performance, especially at high operating currents.

  2. Knee Joint Distraction Compared to Total Knee Arthroplasty for Treatment of End Stage Osteoarthritis: Simulating Long-Term Outcomes and Cost-Effectiveness.

    van der Woude, J A D; Nair, S C; Custers, R J H; van Laar, J M; Kuchuck, N O; Lafeber, F P J G; Welsing, P M J

    2016-01-01

    In end-stage knee osteoarthritis the treatment of choice is total knee arthroplasty (TKA). An alternative treatment is knee joint distraction (KJD), suggested to postpone TKA. Several studies reported significant and prolonged clinical improvement of KJD. To make an appropriate decision regarding the position of this treatment, a cost-effectiveness and cost-utility analysis from healthcare perspective for different age and gender categories was performed. A treatment strategy starting with TKA and a strategy starting with KJD for patients of different age and gender was simulated. To extrapolate outcomes to long-term health and economic outcomes a Markov (Health state) model was used. The number of surgeries, QALYs, and treatment costs per strategy were calculated. Costs-effectiveness is expressed using the cost-effectiveness plane and cost-effectiveness acceptability curves. Starting with KJD the number of knee replacing procedures could be reduced, most clearly in the younger age categories; especially revision surgery. This resulted in the KJD strategy being dominant (more effective with cost-savings) in about 80% of simulations (with only inferiority in about 1%) in these age categories when compared to TKA. At a willingness to pay of 20.000 Euro per QALY gained, the probability of starting with KJD to be cost-effective compared to starting with a TKA was already found to be over 75% for all age categories and over 90-95% for the younger age categories. A treatment strategy starting with knee joint distraction for knee osteoarthritis has a large potential for being a cost-effective intervention, especially for the relatively young patient.

  3. A Bayes Theory-Based Modeling Algorithm to End-to-end Network Traffic

    Zhao Hong-hao

    2016-01-01

    Full Text Available Recently, network traffic has exponentially increasing due to all kind of applications, such as mobile Internet, smart cities, smart transportations, Internet of things, and so on. the end-to-end network traffic becomes more important for traffic engineering. Usually end-to-end traffic estimation is highly difficult. This paper proposes a Bayes theory-based method to model the end-to-end network traffic. Firstly, the end-to-end network traffic is described as a independent identically distributed normal process. Then the Bases theory is used to characterize the end-to-end network traffic. By calculating the parameters, the model is determined correctly. Simulation results show that our approach is feasible and effective.

  4. Effect of one-lung ventilation on end-tidal carbon dioxide during cardiopulmonary resuscitation in a pig model of cardiac arrest.

    Ryu, Dong Hyun; Jung, Yong Hun; Jeung, Kyung Woon; Lee, Byung Kook; Jeong, Young Won; Yun, Jong Geun; Lee, Dong Hun; Lee, Sung Min; Heo, Tag; Min, Yong Il

    2018-01-01

    Unrecognized endobronchial intubation frequently occurs after emergency intubation. However, no study has evaluated the effect of one-lung ventilation on end-tidal carbon dioxide (ETCO2) during cardiopulmonary resuscitation (CPR). We compared the hemodynamic parameters, blood gases, and ETCO2 during one-lung ventilation with those during conventional two-lung ventilation in a pig model of CPR, to determine the effect of the former on ETCO2. A randomized crossover study was conducted in 12 pigs intubated with double-lumen endobronchial tube to achieve lung separation. During CPR, the animals underwent three 5-min ventilation trials based on a randomized crossover design: left-lung, right-lung, or two-lung ventilation. Arterial blood gases were measured at the end of each ventilation trial. Ventilation was provided using the same tidal volume throughout the ventilation trials. Comparison using generalized linear mixed model revealed no significant group effects with respect to aortic pressure, coronary perfusion pressure, and carotid blood flow; however, significant group effect in terms of ETCO2 was found (P < 0.001). In the post hoc analyses, ETCO2 was lower during the right-lung ventilation than during the two-lung (P = 0.006) or left-lung ventilation (P < 0.001). However, no difference in ETCO2 was detected between the left-lung and two-lung ventilations. The partial pressure of arterial carbon dioxide (PaCO2), partial pressure of arterial oxygen (PaO2), and oxygen saturation (SaO2) differed among the three types of ventilation (P = 0.003, P = 0.001, and P = 0.001, respectively). The post hoc analyses revealed a higher PaCO2, lower PaO2, and lower SaO2 during right-lung ventilation than during two-lung or left-lung ventilation. However, the levels of these blood gases did not differ between the left-lung and two-lung ventilations. In a pig model of CPR, ETCO2 was significantly lower during right-lung ventilation than during two-lung ventilation. However

  5. Arteriovenous renal replacement therapy in end-stage left-sided heart failure patients has a detrimental effect on patients with impaired right ventricular function.

    Repasos, Evangelos; Kaldara, Elisabeth; Pantsios, Christos; Kapelios, Chris; Nana, Emmeleia; Vernadakis, Spiridon; Melexopoulou, Christina; Malliaras, Konstantinos; Boletis, John; Nanas, John N

    Chronic intermittent renal replacement therapy(RRT) is an alternate method of decongestion for patients presenting with diuretic-resistant, end-stage heart failure(HF) and cardiorenal syndrome. The optimal method of vascular access has not been confirmed. This study investigated the 6-month outcomes of patients with end-stage HF after the creation of arteriovenous communications (AVC) compared with other means of RRT. We treated 40 patients with chronic, intermittent, ambulatory RRT, of whom 15 (37.5%; Group A) underwent creation of AVC, and 25 (62.5%; Group B) received intraperitoneal (n=6) or internal jugular catheters (n=19) with the goal of achieving body weight stabilization and relief from congestion. The characteristics of the two groups were similar. According to Cox regression analysis, the 6-month rate of death or re-hospitalization for HF was significantly higher in Group A (73%) than in Group B (44%); hazard ratio (HR): 2.58; 95% confidence interval (CI) 1.2-6.2; P=0.02. Over a 6-month follow-up, the cumulative survival was significantly shorter (P=0.03) in Group A (13.8±10 weeks) than in Group B (20.7±7 weeks). In the 15 patients who received AVC, the only independent predictor of adverse outcome at 6 months was serum total bilirubin concentration (HR 2.5; 95% CI 1.1-5.7, p=0.02), whereas in the 25 patients who underwent other means of RRT, pulmonary vascular resistance (PVR) was identified as a risk factor for hospitalization or death at 1-year follow-up (HR 1.26; 95% CI 1.1-1.57, p=0.04). In patients with end-stage HF, the creation of AVC for intermittent RRT was followed by a significant increase in morbidity and mortality in comparison to the safe and effective placement of permanent central venous catheters. Patients with elevated PVR seem to comprise a group at high risk for adverse outcomes after central catheter insertion. Copyright © 2016 Hellenic Society of Cardiology. Published by Elsevier B.V. All rights reserved.

  6. The effect of two different intra-operative end-tidal carbon dioxide tensions on apnoeic duration in the recovery period in horses.

    Thompson, Kate R; Bardell, David

    2016-03-01

    To compare the effect of two different intraoperative end-tidal carbon dioxide tensions on apnoeic duration in the recovery period in horses. Prospective randomized clinical study. Eighteen healthy client-owned adult horses (ASA I-II) admitted for elective surgery. Horses were of a median body mass of 595 (238-706) kg and a mean age of 9 ± 5 years. A standardized anaesthetic protocol was used. Horses were positioned in dorsal recumbency and randomly allocated to one of two groups. Controlled mechanical ventilation (CMV) was adjusted to maintain the end-tidal carbon dioxide tension (Pe'CO2 ) at 40 ± 5 mmHg (5.3 ± 0.7 kPa) (group 40) or 60 ± 5 mmHg (8.0 ± 0.7 kPa) (group 60). Arterial blood gas analysis was performed at the start of the anaesthetic period (T0), at one point during the anaesthetic (T1), immediately prior to disconnection from the breathing system (T2) and at the first spontaneous breath in the recovery box (T3). The time from disconnection from the breathing system to return to spontaneous ventilation (RSV) was recorded. Data were analysed using a two sample t-test or the Mann-Whitney U-test and significance assigned when p breathing significantly earlier than those in group 40, [52 (14-151) and 210 (103-542) seconds, respectively] (p tension (PaO2 ), pH, base excess (BE) and plasma bicarbonate (HCO3-) were not different between the groups at RSV, however, PaO2 was significantly lower in group 60 during (T1) and at the end of anaesthesia (T2). Aiming to maintain intra-operative Pe'CO2 at 60 ± 5 mmHg (8.0 ± 0.7 kPa) in mechanically ventilated horses resulted in more rapid RSV compared with when Pe'CO2 was maintained at 40 ± 5 mmHg (5.3 ± 0.7 kPa). © 2015 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

  7. No Easy Talk: A Mixed Methods Study of Doctor Reported Barriers to Conducting Effective End-of-Life Conversations with Diverse Patients.

    Vyjeyanthi S Periyakoil

    Full Text Available Though most patients wish to discuss end-of-life (EOL issues, doctors are reluctant to conduct end-of-life conversations. Little is known about the barriers doctors face in conducting effective EOL conversations with diverse patients. This mixed methods study was undertaken to empirically identify barriers faced by doctors (if any in conducting effective EOL conversations with diverse patients and to determine if the doctors' age, gender, ethnicity and medical sub-specialty influenced the barriers reported.Mixed-methods study of multi-specialty doctors caring for diverse, seriously ill patients in two large academic medical centers at the end of the training; data were collected from 2010 to 2012.Doctor-reported barriers to EOL conversations with diverse patients.1040 of 1234 potential subjects (84.3% participated. 29 participants were designated as the development cohort for coding and grounded theory analyses to identify primary barriers. The codes were validated by analyses of responses from 50 randomly drawn subjects from the validation cohort (n= 996 doctors. Qualitative responses from the validation cohort were coded and analyzed using quantitative methods. Only 0.01% doctors reported no barriers to conducting EOL conversations with patients. 99.99% doctors reported barriers with 85.7% finding it very challenging to conduct EOL conversations with all patients and especially so with patients whose ethnicity was different than their own. Asian-American doctors reported the most struggles (91.3%, followed by African Americans (85.3%, Caucasians (83.5% and Hispanic Americans (79.3% in conducting EOL conversations with their patients. The biggest doctor-reported barriers to effective EOL conversations are (i language and medical interpretation issues, (ii patient/family religio-spiritual beliefs about death and dying, (iii doctors' ignorance of patients' cultural beliefs, values and practices, (iv patient/family's cultural differences in truth

  8. Effects of different rehabilitation models on erythrocyte deformability and nitrite plus nitrate as end-products of nitric oxide levels in elderly women.

    Filar-Mierzwa, Katarzyna; Wójcik, Barbara; Marchewka, Anna; Dąbrowski, Zbigniew; Superata, Jerzy; Wiśniowski, Zdzisław

    2017-12-01

    The aim of the present study was to analyze the effects of two rehabilitation protocols, dance movement therapy exercises (DMT) and general rehabilitation exercises (GRE), on erythrocyte deformability and plasma levels of nitrite plus nitrate as end products of nitric oxide (NOx) in elderly women. The study included 39 women aged 61-82 years, subjected to either GRE (n = 20) or DMT (n = 19). Women were subjected to 5-months programs of GRE and DMT, with each session lasting no longer than 45-50 min, and the intensity of exercising corresponding to no more than 40-60% of heart rate reserve. Plasma levels of NOx were determined spectrophotometrically before and at the end of the intervention. A significant increase in the total nitrate/nitrite concentration from 1.341 μmol/L to 1.590 μmol/L (7.3%) was observed in women subjected to the DMT rehabilitation program. Furthermore, an increase in erythrocyte deformability was observed in this group at shear stress 0.30. No significant difference was found between the pre- and post-rehabilitation NOx levels of women participating in the GRE program. Participation in DMT rehabilitation program might be reflected by an increase in plasma NOx levels and an improvement of erythrocyte deformability at lesser shear stress, and thus could potentially result in better vascular function. DMT should be offered to older adults, especially to persons who do not find conventional forms of rehabilitation as attractive, as they might refrain from physical activity and suffer from a faster decline in nitric oxide production. Geriatr Gerontol Int 2017; 17: 2479-2484. © 2017 Japan Geriatrics Society.

  9. Effect of biventricular pacing on heart function evaluated by gated blood pool study in patients with end-stage heart failure

    Cholewinski, W.; Tarkowska, A.; Stefaniak, B.; Poniatowicz-Frasunek, E.; Kutarski, A.; Oleszczak, K.

    2002-01-01

    Biventricular cardiac pacing has been used as a complementary form of therapy in patients with severe heart failure. The aim of this study was to evaluate the effect of the synchronous stimulation of both ventricles on the heart function measured by gated blood pool study (GBP). Ten patients (9 men and 1 woman aged 53-74 years) with end-stage heart failure (HF) were studied. In all patients long-term biventricular pacing (BV) was applied. The obtained results were compared with single-chamber stimulation in 5 patients and with sinus rhythm (SR) in 8 patients. All patients underwent repeated GBP with RBC labelled with 740 MBq of 99m Tc-pertechnetate. The LVEF was calculated according to the standard method based on the count rates. Phase analysis was performed with the standard method using first Fourier element. Clinically in almost all patients moderate to important symptomatic improvement has been observed. The analysis of LVEF values revealed that BV pacing resulted in significantly higher values only in comparison with SR (21.6% ±10.3 v. 20.1% ± 10.1; p o± 29.6 v. 13.4 o± 37.6 and 7.4 o± 26.5 v. 6.0 o± 17.1, respectively). However, in comparison with LV pacing, BV stimulation revealed a change of dominant conduction abnormalities with a delay of RV contraction in relation to LV (9.0 o± 17.5 v. -3.0 o± 11.4). Biventricular pacing results in slight improvement of LVEF in patients with heart failure and can be considered a promising approach in patients with end-stage heart failure. Synchronous stimulation of both ventricles not always results in decrease of interventricular shift, however that observation requires further studies on a larger population. (author)

  10. End of Life Care

    ... Related Topics Choosing Wisely Join our e-newsletter! Aging & Health A to Z End of Life Care ... be used. Ice chips, popsicles, moist swabs, or artificial saliva can help prevent the mouth from becoming ...

  11. CENTRIFUGE END CAP

    Beams, J.W.; Snoddy, L.B.

    1960-08-01

    An end cap for ultra-gas centrifuges is designed to impart or remove angular momentum to or from the gas and to bring the entering gas to the temperature of the gas inside the centrifuge. The end cap is provided with slots or fins for adjusting the temperature and the angular momentum of the entering gas to the temperature and momentum of the gas in the centrifuge and is constructed to introduce both the inner and the peripheral stream into the centrifuge.

  12. Effects of wood polymers and extractives on the adsorption of wet-end chemicals and the properties of the sheet - MPKY 03

    Bobacka, V; Lindholm, J; Nurmi, M; Naesman, J [Aabo Akademi, Turku (Finland). Lab. of Paper Chemistry; Holmbom, B; Konn, J; Sundberg, A; Willfoer, S [Aabo Akademi, Turku (Finland). Lab. of Forest Products Chemistry

    1999-12-31

    The effects of deposition of dissolved and colloidal substances (disco, DCS) together with fixing agents on the wet end chemistry, and the paper quality have been studied. Increased amounts of wood resin in handsheets results in lower strength properties and friction of the sheets. Addition of isolated polysaccharides together with wood resin results in higher strength properties compared, at the same resin content, to sheets without added polysaccharides. Disco substances released from TMP were adsorbed/deposited onto different fillers. It is possible to determine the distribution of aggregated wood resin in handsheets of kraft pulp by confocal laser scanning microscopy. Addition of iron salts to a TMP suspension results in a decrease in the brightness of the fibers. The adsorption of cationic starch and cationic polyacrylamide was studied as well as the flocculation of a peroxide bleached TMP and mixture of TMP and kraft pulp in the presence of retention aids and fixing agents. The fixing agent had a minor effect on the flocculation in peroxide bleached TMP, while cationic starch induced flocculation after a threshold. When added together, cationic starch induced flocculation immediately. The retention of carbohydrates in the mixture was not much influenced by the presence of fixing agents and retention aids, but the extractives were efficiently retained. Colloidal substances adsorb both cationic starch and polyacrylamide. Of the dissolved substances, pectic acids are most efficiently aggregated. (orig.)

  13. Effects of wood polymers and extractives on the adsorption of wet-end chemicals and the properties of the sheet - MPKY 03

    Bobacka, V.; Lindholm, J.; Nurmi, M.; Naesman, J. [Aabo Akademi, Turku (Finland). Lab. of Paper Chemistry; Holmbom, B.; Konn, J.; Sundberg, A.; Willfoer, S. [Aabo Akademi, Turku (Finland). Lab. of Forest Products Chemistry

    1998-12-31

    The effects of deposition of dissolved and colloidal substances (disco, DCS) together with fixing agents on the wet end chemistry, and the paper quality have been studied. Increased amounts of wood resin in handsheets results in lower strength properties and friction of the sheets. Addition of isolated polysaccharides together with wood resin results in higher strength properties compared, at the same resin content, to sheets without added polysaccharides. Disco substances released from TMP were adsorbed/deposited onto different fillers. It is possible to determine the distribution of aggregated wood resin in handsheets of kraft pulp by confocal laser scanning microscopy. Addition of iron salts to a TMP suspension results in a decrease in the brightness of the fibers. The adsorption of cationic starch and cationic polyacrylamide was studied as well as the flocculation of a peroxide bleached TMP and mixture of TMP and kraft pulp in the presence of retention aids and fixing agents. The fixing agent had a minor effect on the flocculation in peroxide bleached TMP, while cationic starch induced flocculation after a threshold. When added together, cationic starch induced flocculation immediately. The retention of carbohydrates in the mixture was not much influenced by the presence of fixing agents and retention aids, but the extractives were efficiently retained. Colloidal substances adsorb both cationic starch and polyacrylamide. Of the dissolved substances, pectic acids are most efficiently aggregated. (orig.)

  14. The role of the principle of double effect in ethics education at US medical schools and its potential impact on pain management at the end of life.

    Macauley, Robert

    2012-03-01

    Because opioids can suppress respiratory drive, the principle of double effect (PDE) has been used to justify their use for terminally ill patients. Recent studies, however, suggest that the risk of respiratory depression in typical end-of-life (EOL) situations may be overstated and that heightened concern for this rare occurrence can lead to inadequate treatment of pain. The purpose of this study is to examine the role of the PDE in medical school ethics education, with specific reference to its potential impact on pain management at EOL. After obtaining institutional review board approval, an electronic survey was sent to ethics educators at every allopathic medical school in the USA. One-third of ethics educators felt that opioids were 'likely' to cause significant respiratory depression that could hasten death. Educators' opinions of opioid effects did not influence their view of the relevance of the PDE, with approximately 70% deeming it relevant to EOL care. Only 15% of ethics educators believed that associating the PDE with opioid use might discourage clinicians from optimally treating pain, out of concern for respiratory depression. This study demonstrates that a significant minority of ethics educators believe, contrary to current evidence, that opioids are 'likely' to cause significant respiratory depression that could hasten death in terminally ill patients. Yet, many of those who do not feel this is likely still rely on the PDE to justify this possibility, potentially (and unknowingly) contributing to clinical misperceptions and underutilisation of opioids at EOL.

  15. N-Acetyl Cysteine Attenuated the Deleterious Effects of Advanced Glycation End-Products on the Kidney of Non-Diabetic Rats

    Karina Thieme

    2016-11-01

    Full Text Available Aim: To assess the renal effects of chronic exposure to advanced glycation end-products (AGEs in the absence of diabetes and the potential impact of concomitant treatment with the antioxidant N-acetyl cysteine (NAC. Methods: Wistar rats received intraperitoneally 20 mg/kg/day of albumin modified (AlbAGE or not (AlbC by advanced glycation for 12 weeks and oral NAC (600mg/L; AlbAGE+NAC and AlbC+NAC, respectively. Biochemical, urinary and renal morphological analyses; carboxymethyl-lysine (CML, an AGE, CD68 (macrophage infiltration, and 4-hydroxynonenal (4-HNE, marker of oxidative stress immunostaining; intrarenal mRNA expression of genes belonging to pathways related to AGEs (Ager, Ddost, Nfkb1, renin-angiotensin system (Agt, Ren, Ace, fibrosis (Tgfb1, Col4a1, oxidative stress (Nox4, Txnip, and apoptosis (Bax, Bcl2; and reactive oxidative species (ROS content were performed. Results: AlbAGE significantly increased urine protein-to-creatinine ratio; glomerular area; renal CML content and macrophage infiltration; expression of Ager, Nfkb1, Agt, Ren, Tgfb1, Col4a1, Txnip, Bax/Bcl2 ratio; and 4-HNE and ROS contents. Some of these effects were attenuated by NAC concomitant treatment. Conclusion: Because AGEs are highly consumed in modern diets and implicated in the progression of different kidney diseases, NAC could be a therapeutic intervention to decrease renal damage, considering that long-term restriction of dietary AGEs is difficult to achieve in practice.

  16. Minimized Capillary End Effect During CO2 Displacement in 2-D Micromodel by Manipulating Capillary Pressure at the Outlet Boundary in Lattice Boltzmann Method

    Kang, Dong Hun; Yun, Tae Sup

    2018-02-01

    We propose a new outflow boundary condition to minimize the capillary end effect for a pore-scale CO2 displacement simulation. The Rothman-Keller lattice Boltzmann method with multi-relaxation time is implemented to manipulate a nonflat wall and inflow-outflow boundaries with physically acceptable fluid properties in 2-D microfluidic chip domain. Introducing a mean capillary pressure acting at CO2-water interface to the nonwetting fluid at the outlet effectively prevents CO2 injection pressure from suddenly dropping upon CO2 breakthrough such that the continuous CO2 invasion and the increase of CO2 saturation are allowed. This phenomenon becomes most pronounced at capillary number of logCa = -5.5, while capillary fingering and massive displacement of CO2 prevail at low and high capillary numbers, respectively. Simulations with different domain length in homogeneous and heterogeneous domains reveal that capillary pressure and CO2 saturation near the inlet are reproducible compared with those with a proposed boundary condition. The residual CO2 saturation uniquely follows the increasing tendency with increasing capillary number, corroborated by experimental evidences. The determination of the mean capillary pressure and its sensitivity are also discussed. The proposed boundary condition is commonly applicable to other pore-scale simulations to accurately capture the spatial distribution of nonwetting fluid and corresponding displacement ratio.

  17. Evaluation the effect of breathing filters on end-tidal carbon dioxide during inferior abdominal surgery in infants and changes of tidal volume and respiratory rate needs for preventing of increasing end-tidal carbon dioxide.

    Sajedi, Parvin; Abooei, Mohsen; Shafa, Amir; Karbalaei, Mahboobeh; Babaei, Atefeh

    2016-01-01

    The aim of this study was to prevent of increasing end-tidal carbon dioxide (ETCO 2) with changing of vital capacity and respiratory rate when using of birthing filter in infants. In a randomized clinical trial study, ninety-four infant' patients were studied in three groups. Basic values, such as peak inspiratory pressure, tidal volume, minute ventilation, respiratory rate, and partial pressure of ET CO 2 (PETCO 2 ) level had been evaluated after intubation, 10 min after intubation and 10 min after filter insertion. In the first group, patients only observed for changing in ETCO 2 level. In the second and the third groups, respiratory rates and tidal volume had been increased retrospectively, until that ETCO 2 ≤35 mmHg was received. We used ANOVA, Chi-square, and descriptive tests for data analysis. P Tidal volume 10 min after filter insertion was statistically higher in Group 3 (145.0 ± 26.3 ml) versus 129.3 ± 38.9 ml in Group 1 and 118.7 ± 20.8 ml in Group 2 ( P = 0.02). Furthermore, respiratory rate at this time was statistically higher in Group 2 (25.82 ± 0.43) versus Groups 1 and 3 (21.05 ± 0.20 ml and 21.02 ± 0.60 ml, respectively) ( P = 0.001). Minute volume and PETCO 2 level were statistically significant between Group 1 and the other two groups after filter insertion ( P = 0.01 and P = 0.00,1 respectively). With changing the vital capacity and respiratory rate we can control PETCO 2 level ≤35 mmHg during using of birthing filters in infants. We recommend this instrument during anesthesia of infants.

  18. Wireless network of stand-alone end effect probes for soil in situ permittivity measurements over the 100MHZ-6GHz frequency range

    Demontoux, François; Bircher, Simone; Ruffié, Gilles; Bonnaudiin, Fabrice; Wigneron, Jean-Pierre; Kerr, Yann

    2017-04-01

    Microwave remote sensing and non-destructive analysis are a powerful way to provide properties estimation of materials. Numerous applications using microwave frequency behavior of materials (remote sensing above land surfaces, non-destructive analysis…) are strongly dependent on the material's permittivity (i.e. dielectric properties). This permittivity depends on numerous parameters such as moisture, texture, temperature, frequency or bulk density. Permittivity measurements are generally carried out in the laboratory. Additionally, dielectric mixing models allow, over a restricted range of conditions, the assessment of a material's permittivity. in-situ measurements are more difficult to obtain. Some in situ measurement probes based on permittivity properties of soil exist (e.g. Time Domain Reflectometers and Transmissometers, capacitance and impedance sensors). They are dedicated to the acquisition of soil moisture data based on permittivity (mainly the real part) estimations over a range of frequencies from around 50 MHz to 1 or 2 GHz. Other Dielectric Assessment Kits exist but they are expensive and they are rather dedicated to laboratory measurements. Furthermore, the user can't address specific issues related to particular materials (e.g. organic soils) or specific measurement conditions (in situ long time records). At the IMS Laboratory we develop probes for in situ soil permittivity measurements (real and imaginary parts) in the 0.5 - 6 GHz frequency range. They are based on the end effect phenomenon of a coaxial waveguide and so are called end effect probes in this paper. The probes can be connected to a portable Vector Network Analyzer (VNA, ANRITSU MS2026A) for the S11 coefficient measurements needed to compute permittivity. It is connected to a PC to record data using an USB connection. This measurement set-up is already used for in situ measurement of soil properties in the framework of the European Space Agency's (ESA) SMOS space mission. However

  19. Is Trait Rumination Associated with the Ability to Generate Effective Problem Solving Strategies? Utilizing Two Versions of the Means-Ends Problem-Solving Test.

    Hasegawa, Akira; Nishimura, Haruki; Mastuda, Yuko; Kunisato, Yoshihiko; Morimoto, Hiroshi; Adachi, Masaki

    This study examined the relationship between trait rumination and the effectiveness of problem solving strategies as assessed by the Means-Ends Problem-Solving Test (MEPS) in a nonclinical population. The present study extended previous studies in terms of using two instructions in the MEPS: the second-person, actual strategy instructions, which has been utilized in previous studies on rumination, and the third-person, ideal-strategy instructions, which is considered more suitable for assessing the effectiveness of problem solving strategies. We also replicated the association between rumination and each dimension of the Social Problem-Solving Inventory-Revised Short Version (SPSI-R:S). Japanese undergraduate students ( N  = 223) completed the Beck Depression Inventory-Second Edition, Ruminative Responses Scale (RRS), MEPS, and SPSI-R:S. One half of the sample completed the MEPS with the second-person, actual strategy instructions. The other participants completed the MEPS with the third-person, ideal-strategy instructions. The results showed that neither total RRS score, nor its subscale scores were significantly correlated with MEPS scores under either of the two instructions. These findings taken together with previous findings indicate that in nonclinical populations, trait rumination is not related to the effectiveness of problem solving strategies, but that state rumination while responding to the MEPS deteriorates the quality of strategies. The correlations between RRS and SPSI-R:S scores indicated that trait rumination in general, and its brooding subcomponent in particular are parts of cognitive and behavioral responses that attempt to avoid negative environmental and negative private events. Results also showed that reflection is a part of active problem solving.

  20. Combined Effects of Ventilation Mode and Positive End-Expiratory Pressure on Mechanics, Gas Exchange and the Epithelium in Mice with Acute Lung Injury

    Thammanomai, Apiradee; Hamakawa, Hiroshi; Bartolák-Suki, Erzsébet; Suki, Béla

    2013-01-01

    The accepted protocol to ventilate patients with acute lung injury is to use low tidal volume (VT) in combination with recruitment maneuvers or positive end-expiratory pressure (PEEP). However, an important aspect of mechanical ventilation has not been considered: the combined effects of PEEP and ventilation modes on the integrity of the epithelium. Additionally, it is implicitly assumed that the best PEEP-VT combination also protects the epithelium. We aimed to investigate the effects of ventilation mode and PEEP on respiratory mechanics, peak airway pressures and gas exchange as well as on lung surfactant and epithelial cell integrity in mice with acute lung injury. HCl-injured mice were ventilated at PEEPs of 3 and 6 cmH2O with conventional ventilation (CV), CV with intermittent large breaths (CVLB) to promote recruitment, and a new mode, variable ventilation, optimized for mice (VVN). Mechanics and gas exchange were measured during ventilation and surfactant protein (SP)-B, proSP-B and E-cadherin levels were determined from lavage and lung homogenate. PEEP had a significant effect on mechanics, gas exchange and the epithelium. The higher PEEP reduced lung collapse and improved mechanics and gas exchange but it also down regulated surfactant release and production and increased epithelial cell injury. While CVLB was better than CV, VVN outperformed CVLB in recruitment, reduced epithelial injury and, via a dynamic mechanotransduction, it also triggered increased release and production of surfactant. For long-term outcome, selection of optimal PEEP and ventilation mode may be based on balancing lung physiology with epithelial injury. PMID:23326543

  1. The effects of FK1706 on nerve regeneration and bladder function recovery following an end-to-side neurorrhaphy in rats.

    Gao, Wansheng; He, Xiangfei; Li, Yunlong; Wen, Jianguo

    2017-11-07

    Immunophilin ligands are neuroregenerative agents binding to FK506 binding proteins, by which stimulate recovery of neurons in a variety of injury nerves. FK1706 is a novel immunophilin ligand which has neuroprotective and neuroregenerative effects but without immunosuppressive activity. At present, most reports about FK1706 in ameliorating nerve injury and functional recovery are limited to cavernous nerve injury and erectile function recovery. This study aimed to demonstrate the effects of FK1706 on nerve regeneration and bladder function recovery following an end-to-side neurorrhaphy in rat models. The numbers of regenerated myelinated axons of the pelvic parasympathetic nerve (PPN) in the three groups' rats (FK1706 + ETS, ETS and control groups) were evaluated. Their intravesical pressure (IVP), S100β and growth associated protein 43 (GAP43) expressions were also compared. In FK1706 + ETS group, 90% the rats showed that the frequency of FG labeled neurons was larger than the 3.5 cutoff value, 100% the rats showed that the frequency of FG-FB double-labeled neurons was larger than the 5.5 cutoff value. The average maximum of IVP in FK1706 + ETS group reached 76.3% of the value in control group. Their average number of myelinated axons of regenerated PPN reached 80% of the amount in control group. The nerve regeneration-associated markers data indicated that the expression level of S100β and GAP43 in FK1706 + ETS group was approximately 2-fold higher than that of ETS group (P side neurorrhaphy, FK1706 effectively enhanced the nerve regeneration and bladder function recovery.

  2. End of an era?

    Abrahamson, Peter

    2016-01-01

    At the end of 2015, China put an end to the one-child policy (OCP), thereby terminating the largest family planning program in human history. For nearly four decades it had shaped relations between generations and between men and women to an extent never before seen. Today, China struggles with t...... because of the strong preference for boys, which has led to so-called “bare branches:” Chinese men who are not able to find a spouse or have to rely on “mail-order brides.” The paper concludes that the OCP has come to an end, but the unintended consequences prevail.......At the end of 2015, China put an end to the one-child policy (OCP), thereby terminating the largest family planning program in human history. For nearly four decades it had shaped relations between generations and between men and women to an extent never before seen. Today, China struggles...... cultural values and legal prescriptions foresee reciprocal care responsibilities between generations. This has led to an enormous care deficit, which triggers conflicts between both genders and generations. A second major unintended consequence has been a skewed gender ratio of only 18 women per 20 men...

  3. End the nuclear threat

    Douglas, Michael

    2005-01-01

    In 1945 the United Nations was founded with one major goal in mind, and I quote, 'to save succeeding generations from the scourge of war.' The founders noted that twice in the 20th Century major wars had brought 'untold sorrow to mankind.' Since its founding, 191 nations have joined the UN. We have no other place where all nations can work together for peace, a place where we can use verbal conflict rather than armed conflict to solve problems. And often, the UN, with US support, has provided armed force to help ensure the peace. The entire planet now faces global challenges including ensuring bio-diversity and ending the destruction of thousands of species; reversing the depletion of fishing stocks; controlling ocean dumping; preventing ozone depletion; halting global warming; controlling and eliminating terrorism and weapons of mass destruction; fighting pandemic diseases; ending the tragedy of crushing poverty and lack of clean drinking water; and addressing crises arising from failed States. No nation or even a small group of nations can succeed in addressing these issues alone. The United Nations is based on political insights that have led to successful governance principles and enhanced the wealth of nations. These values include market freedoms, religious liberty, an independent judiciary, government transparency and accountability, democracy, and a high level of respect for civil liberties and human rights. They have evolved into nearly universal goals and norms. The countries that have adhered to these principles are the most secure and healthy. The United Nations is guided by such countries, and simultaneously provides the only viable forum for the expression of the aspirations of the poor and the weak. The establishment of international norms of conduct is where idealism informs realism. We are called to nothing less than moral leadership. When moral leadership is coupled with power, it galvanizes the world. Moral leadership requires living up to one

  4. Effect of Amaranthus on Advanced Glycation End-Products Induced Cytotoxicity and Proinflammatory Cytokine Gene Expression in SH-SY5Y Cells

    Warisa Amornrit

    2015-09-01

    Full Text Available Amaranthus plants, or spinach, are used extensively as a vegetable and are known to possess medicinal properties. Neuroinflammation and oxidative stress play a major role in the pathogenesis of many neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. Advanced glycation end-products (AGEs cause cell toxicity in the human neuronal cell line, SH-SY5Y, through an increase in oxidative stress, as shown by reducing cell viability and increasing cell toxicity in a dose-dependent manner. We found that preincubation of SH-SY5Y cells with either petroleum ether, dichloromethane or methanol extracts of A. lividus and A. tricolor dose-dependently attenuated the neuron toxicity caused by AGEs treatment. Moreover, the results showed that A. lividus and A. tricolor extracts significantly downregulated the gene expression of the pro-inflammatory cytokines, TNF-α, IL-1 and IL-6 genes in AGEs-induced cells. We concluded that A. lividus and A. tricolor extracts not only have a neuroprotective effect against AGEs toxicity, but also have anti-inflammatory activity by reducing pro-inflammatory cytokine gene expression. This suggests that Amaranthus may be useful for treating chronic inflammation associated with neurodegenerative disorders.

  5. The in vitro protective effects of curcumin and demethoxycurcumin in Curcuma longa extract on advanced glycation end products-induced mesangial cell apoptosis and oxidative stress.

    Liu, Ji-ping; Feng, Liang; Zhu, Mao-mao; Wang, Ru-Shang; Zhang, Ming-hua; Hu, Shao-ying; Jia, Xiao-bin; Wu, Jin-Jie

    2012-11-01

    Curcuma longa L. (CLL), a traditional herbal medicine, has been widely used for the prevention of diabetic vascular complications in recent years. However, the protective effects of curcuminoids in CLL on the AGEs-induced damage to mesangial cell are not fully understood. In this present study, dihydroethidium, superoxide dismutase kit, malondialdehyde kit, and acridine orange/ethidium bromide staining methods were used to evaluate the activities of curcumin and demethoxycurcumin (10(-11)-10(-9) M) on AGEs-induced oxidative stress and apoptosis, which were associated with the damage to mesangial cell. The results showed that these two compounds could significantly restore advanced glycation end products (AGEs)-induced apoptosis to normal levels (IC50 = 3.874 × 10(-11) M for curcumin and IC50 = 6.085 × 10(-11) M for demethoxycurcumin) and reduce remarkably reactive oxygen species generation in mesangial cell. Furthermore, curcumin and demethoxycurcumin dramatically elevated AGEs-decreased superoxide dismutase activity while significantly reducing AGEs-increased malondialdehyde content in cell culture supernatant. Our results suggest that both curcumin and demethoxycurcumin have a significant protective potential to the prevention of diabetic nephropathy. Georg Thieme Verlag KG Stuttgart · New York.

  6. Beneficial effects of banana (Musa sp. var. elakki bale) flower and pseudostem on hyperglycemia and advanced glycation end-products (AGEs) in streptozotocin-induced diabetic rats.

    Bhaskar, Jamuna J; Shobha, Mysore S; Sambaiah, Kari; Salimath, Paramahans V

    2011-09-01

    Diabetes is a chronic health problem and major cause of death in most of the countries. Diet management plays an important role in controlling diabetes and its complications along with insulin and drugs. We have examined the effect of banana (Musa sp. var. elakki bale) flower and pseudostem on hyperglycemia and advanced glycation end-products (AGEs) in streptozotocin-induced diabetic rats. Our results indicated that banana flower and pseudostem have low glycemic index and have a high content of dietary fiber and antioxidants. Diabetic symptoms like hyperglycemia, polyuria, polyphagia, polydipsia, urine sugar, and body weight were ameliorated in banana flower- and pseudostem-treated rats. Increased glomerular filtration rate in the diabetic group (5.1 ± 0.22 ml/min) was decreased in banana flower-fed (2.5 ± 0.37 ml/min) and pseudostem-fed (3.0 ± 0.45 ml/min) groups and were significant at P banana flower- and pseudostem-fed groups, it was reduced to 9.21 ± 0.32 and 9.29 ± 0.24 μg/mg protein, respectively, and were significant at P banana flower and pseudostem have anti-diabetic and anti-AGEs properties and are beneficial as food supplements for diabetics.

  7. Effects of positive end expiratory pressure administration during non-invasive ventilation in patients affected by amyotrophic lateral sclerosis: A randomized crossover study.

    Crescimanno, Grazia; Greco, Francesca; Arrisicato, Salvo; Morana, Noemi; Marrone, Oreste

    2016-10-01

    No studies have evaluated the impact of different settings of non-invasive ventilation (NIV) in patients affected by amyotrophic lateral sclerosis (ALS). We explored consequences of positive end-expiratory pressure (PEEP) application on effectiveness of ventilation, sleep architecture and heart rate variability (HRV) in patients with ALS naïve to ventilatory treatment. In two consecutive nights, 25 patients received in random order 0 or 4 cm H2 0 of PEEP during nocturnal NIV administration (Idea Ultra ResMed) with the same level of total positive inspiratory pressure. Polysomnographies were performed to evaluate sleep and NIV quality, as well as HRV. HRV was analyzed on 4-h periods and on 5-min segments of stable NREM sleep. We did not observe differences in gas exchanges during NIV with and without PEEP. Conversely, during PEEP application increases in leaks (41.4 ± 29.3% vs 31.0 ± 25.7%, P = 0.0007) and in autotriggerings (4.2 (IQR 1.3-10.0) vs 0.9 (IQR 0.0-3.0) events/h, P NIV was associated with worse NIV and sleep quality and with higher sympathetic activity. © 2016 Asian Pacific Society of Respirology.

  8. Effects of respiratory rate, plateau pressure, and positive end-expiratory pressure on PaO2 oscillations after saline lavage.

    Baumgardner, James E; Markstaller, Klaus; Pfeiffer, Birgit; Doebrich, Marcus; Otto, Cynthia M

    2002-12-15

    One of the proposed mechanisms of ventilator-associated lung injury is cyclic recruitment of atelectasis. Collapse of dependent lung regions with every breath should lead to large oscillations in PaO2 as shunt varies throughout the respiratory cycle. We placed a fluorescence-quenching PO2 probe in the brachiocephalic artery of six anesthetized rabbits after saline lavage. Using pressure-controlled ventilation with oxygen, ventilator settings were varied in random order over three levels of positive end-expiratory pressure (PEEP), respiratory rate (RR), and plateau pressure minus PEEP (Delta). Dependence of the amplitude of PaO2 oscillations on PEEP, RR, and Delta was modeled by multiple linear regression. Before lavage, arterial PO2 oscillations varied from 3 to 22 mm Hg. After lavage, arterial PO2 oscillations varied from 5 to 439 mm Hg. Response surfaces showed markedly nonlinear dependence of amplitude on PEEP, RR, and Delta. The large PaO2 oscillations observed provide evidence for cyclic recruitment in this model of lung injury. The important effect of RR on the magnitude of PaO2 oscillations suggests that the static behavior of atelectasis cannot be accurately extrapolated to predict dynamic behavior at realistic breathing frequencies.

  9. Academic Essay Writing and Analysis of Two World Effective Articles: “The End Of History” and “Modernity, Incomplete Project”

    H. R. Rahmanizade Dehkordi

    2016-07-01

    Full Text Available One way to learn how to write an academic article is by analyzing some good and effective articles and taking lessons from them. In this way, I have chosen two articles from two different political positions, i.e. “The End of History” by Francis Fukuyama from the Right and “Modernity, Unfinished/Incomplete Project” by Jürgen Habermas from the Left. The prime purpose of this paper is to provide a translation and summary of Fukuyama’s article and the second objective is to analyze the text for extracting some theses, assumptions, research questions , etc. and finally is to compare these lessons with those that I have learned from analyzing the Habermas’s article (that I have published in a philosophical academic journal “Hekmat Va Falsafeh”. The author shows how these experiences can provide some criteria for writing academic articles and evaluating them. As we see in this paper, identifying a radical thesis, supporting it with convincing evidence and reasons and making a contribution to the body of knowledge, is the most characteristic feature of a good and academic article. Furthermore, we show that how two articles can be used as interdisciplinary methods for developing themes and ideas in a discourse.

  10. Mere end marionetdukker

    Lehmann-Jacobsen, Emilie Tinne

    2016-01-01

    Pressefrihed er en mangelvare i flere sydøstasiatiske lande, og journalisterne beskrives sjældent som andet end viljeløse marionetdukker for de siddende magthavere. Det er dog langt fra den fulde fortælling. Men myten lever videre til frustration for de fagligt stolte journalister og med konsekve......Pressefrihed er en mangelvare i flere sydøstasiatiske lande, og journalisterne beskrives sjældent som andet end viljeløse marionetdukker for de siddende magthavere. Det er dog langt fra den fulde fortælling. Men myten lever videre til frustration for de fagligt stolte journalister og med...

  11. The end of truth?

    C. W. du Toit

    1997-01-01

    As we are approaching the end of the century, many ideas, systems, and certainties, previously taken for granted, seem to be questioned, altered and rejected. One of these is the notion of truth, which pervades the very fibre of Western thinking. Rejecting the relevant critique as simply a postmodem fad, this article proceeds to give attention to the questions regarding the end of religious, scientific, and metaphysical truth. Truth and power are dealt with, as well as the narrative nature of...

  12. Effect of an End-of-Life Planning Intervention on the completion of advance directives in homeless persons: a randomized trial.

    Song, John; Ratner, Edward R; Wall, Melanie M; Bartels, Dianne M; Ulvestad, Nancy; Petroskas, Dawn; West, Melissa; Weber-Main, Anne Marie; Grengs, Leah; Gelberg, Lillian

    2010-07-20

    Few interventions have focused on improving end-of-life care for underserved populations, such as homeless persons. To determine whether homeless persons will complete a counseling session on advance care planning and fill out a legal advance directive designed to assess care preferences and preserve the dignity of marginalized persons. Prospective, single-blind, randomized trial comparing self-guided completion of an advance directive with professionally assisted advance care planning. (ClinicalTrials.gov registration number: NCT00546884) 8 sites serving homeless persons in Minneapolis, Minnesota. 262 homeless persons recruited between November 2007 and August 2008. Minimal, self-guided intervention consisting of advance directive forms and written educational information versus a one-on-one advance planning intervention consisting of counseling and completing an advance directive with a social worker. Rate of advance directive completion, assessed by inspection of completed documents. The overall completion rate for advance directives was 26.7% (95% CI, 21.5% to 32.5%), with a higher rate in the counselor-guided group (37.9%) than in the self-guided group (12.8%) (CI of adjusted difference, 15.3 to 34.3 percentage points). This difference persisted across all sites and most subgroups. The advance directive's 4 clinical scenarios found a preference for surrogate decision making in 29% to 34% of written responses. Sampling was limited to a more stable subset of the homeless population in Minneapolis and may have been subject to selection bias. Modest compensation to complete the preintervention survey could have influenced participants to complete advance directives. Both a simple and complex intervention successfully engaged a diverse sample of homeless persons in advance care planning. One-on-one assistance significantly increased the completion rate. Homeless persons can respond to an intervention to plan for end-of-life care and can express specific preferences

  13. Sensitivity of predictions in an effective model: Application to the chiral critical end point position in the Nambu-Jona-Lasinio model

    Biguet, Alexandre; Hansen, Hubert; Brugiere, Timothee; Costa, Pedro; Borgnat, Pierre

    2015-01-01

    The measurement of the position of the chiral critical end point (CEP) in the QCD phase diagram is under debate. While it is possible to predict its position by using effective models specifically built to reproduce some of the features of the underlying theory (QCD), the quality of the predictions (e.g., the CEP position) obtained by such effective models, depends on whether solving the model equations constitute a well- or ill-posed inverse problem. Considering these predictions as being inverse problems provides tools to evaluate if the problem is ill-conditioned, meaning that infinitesimal variations of the inputs of the model can cause comparatively large variations of the predictions. If it is ill-conditioned, it has major consequences because of finite variations that could come from experimental and/or theoretical errors. In the following, we shall apply such a reasoning on the predictions of a particular Nambu-Jona-Lasinio model within the mean field + ring approximations, with special attention to the prediction of the chiral CEP position in the (T-μ) plane. We find that the problem is ill-conditioned (i.e. very sensitive to input variations) for the T-coordinate of the CEP, whereas, it is well-posed for the μ-coordinate of the CEP. As a consequence, when the chiral condensate varies in a 10MeV range, μ CEP varies far less. As an illustration to understand how problematic this could be, we show that the main consequence when taking into account finite variation of the inputs, is that the existence of the CEP itself cannot be predicted anymore: for a deviation as low as 0.6% with respect to vacuum phenomenology (well within the estimation of the first correction to the ring approximation) the CEP may or may not exist. (orig.)

  14. The effects of feeding resistant starch on apparent total tract macronutrient digestibility, faecal characteristics and faecal fermentative end-products in healthy adult dogs.

    Beloshapka, Alison N; Alexander, Lucille G; Buff, Preston R; Swanson, Kelly S

    2014-01-01

    The benefits of whole grain consumption have been studied in human subjects, but little research exists on their effects in dogs. The objective of the present study was to test the effects of resistant starch (RS) in the diet of healthy adult dogs. Twelve adult Miniature Schnauzer dogs (eight males, four females; mean age: 3·3 (1·6) years; mean body weight: 8·4 (1·2) kg; mean body condition score: D/ideal) were randomly allotted to one of three treatment groups, which consisted of different amounts of RS supplied in a biscuit format. Dogs received either 0, 10 or 20 g biscuits per d (estimated to be 0, 2·5 or 5 g RS per d) that were fed within their daily energetic allowance. A balanced Latin square design was used, with each treatment period lasting 21 d (days 0-17 adaptation; days 18-21 fresh and total faecal collection). All dogs were fed the same diet to maintain body weight throughout the study. Dogs fed 5 g RS per d had lower (P = 0·03) fat digestibility than dogs fed 0 gRS per d, but DM, organic matter and crude protein digestibilities were not affected. Faecal fermentative end-products, including SCFA and branched-chain fatty acids, ammonia, phenols and indoles, and microbial populations were not affected. The minor changes observed in the present study suggest the RS doses provided to the dogs were too low. Further work is required to assess the dose of RS required to affect gut health.

  15. Sensitivity of predictions in an effective model: Application to the chiral critical end point position in the Nambu-Jona-Lasinio model

    Biguet, Alexandre; Hansen, Hubert; Brugiere, Timothee [Universite Claude Bernard de Lyon, Institut de Physique Nucleaire de Lyon, CNRS/IN2P3, Villeurbanne Cedex (France); Costa, Pedro [Universidade de Coimbra, Centro de Fisica Computacional, Departamento de Fisica, Coimbra (Portugal); Borgnat, Pierre [CNRS, l' Ecole normale superieure de Lyon, Laboratoire de Physique, Lyon Cedex 07 (France)

    2015-09-15

    The measurement of the position of the chiral critical end point (CEP) in the QCD phase diagram is under debate. While it is possible to predict its position by using effective models specifically built to reproduce some of the features of the underlying theory (QCD), the quality of the predictions (e.g., the CEP position) obtained by such effective models, depends on whether solving the model equations constitute a well- or ill-posed inverse problem. Considering these predictions as being inverse problems provides tools to evaluate if the problem is ill-conditioned, meaning that infinitesimal variations of the inputs of the model can cause comparatively large variations of the predictions. If it is ill-conditioned, it has major consequences because of finite variations that could come from experimental and/or theoretical errors. In the following, we shall apply such a reasoning on the predictions of a particular Nambu-Jona-Lasinio model within the mean field + ring approximations, with special attention to the prediction of the chiral CEP position in the (T-μ) plane. We find that the problem is ill-conditioned (i.e. very sensitive to input variations) for the T-coordinate of the CEP, whereas, it is well-posed for the μ-coordinate of the CEP. As a consequence, when the chiral condensate varies in a 10MeV range, μ {sub CEP} varies far less. As an illustration to understand how problematic this could be, we show that the main consequence when taking into account finite variation of the inputs, is that the existence of the CEP itself cannot be predicted anymore: for a deviation as low as 0.6% with respect to vacuum phenomenology (well within the estimation of the first correction to the ring approximation) the CEP may or may not exist. (orig.)

  16. Glucagon-like peptide-1 counteracts the detrimental effects of Advanced Glycation End-Products in the pancreatic beta cell line HIT-T 15

    Puddu, A.; Storace, D.; Durante, A.; Odetti, P.; Viviani, G.L.

    2010-01-01

    Research highlights: → GLP-1 prevents AGEs-induced cell death. → GLP-1 prevents AGEs-induced oxidative stress. → GLP-1 ameliorated AGEs-induced cell dysfunction. → GLP-1 attenuates AGEs-induced RAGE increment. → GLP-1 counteracts AGEs-induced pancreatic cell death and dysfunction. -- Abstract: Advanced Glycation End-Products (AGEs), a group of compounds resulting from the non-enzymatic reaction of reducing sugars with the free amino group of proteins, are implicated in diabetic complications. We previously demonstrated that exposure of the pancreatic islet cell line HIT-T 15 to high concentrations of AGEs significantly decreases cell proliferation and insulin secretion, and affects transcription factors regulating insulin gene transcription. The glucagon-like peptide-1 (GLP-1) is an incretin hormone that increases proinsulin biosynthesis, stimulates insulin secretion, and improves pancreatic beta-cell viability. The aim of this work was to investigate the effects of GLP-1 on the function and viability of HIT-T 15 cells cultured with AGEs. HIT-T 15 cells were cultured for 5 days in presence of AGEs alone, or supplemented with 10 nmol/l GLP-1. Cell viability, insulin secretion, redox balance, and expression of the AGEs receptor (RAGE) were then determined. The results showed that GLP-1 protected beta cell against AGEs-induced cell death preventing both apoptosis and necrosis. Moreover, addition of GLP-1 to the AGEs culture medium restored the redox balance, improved the responsiveness to glucose, and attenuated AGEs-induced RAGE expression. These findings provide evidence that GLP-1 protects beta cells from the dangerous effects of AGEs.

  17. The effect of an advanced glycation end-product crosslink breaker and exercise training on vascular function in older individuals: a randomized factorial design trial.

    Oudegeest-Sander, M.H.; Olde Rikkert, M.G.M.; Smits, P.; Thijssen, D.H.J.; Dijk, A.P.J. van; Levine, B.D.; Hopman, M.T.E.

    2013-01-01

    Aging leads to accumulation of irreversible advanced glycation end-products (AGEs), contributing to vascular stiffening and endothelial dysfunction. When combined with the AGE-crosslink breaker Alagebrium, exercise training reverses cardiovascular aging in experimental animals. This study is the

  18. Open-Ended Evolution

    Taylor, Tim; Bedau, Mark A.; Channon, Alastair

    2016-01-01

    This report describes the First Workshop on Open-Ended Evolution: Recent Progress and Future Milestones (OEE1), held during the ECAL 2015 conference at the University of York, U.K., in July 2015. We briefly summarise the content of the talks and discussions and the workshop, and provide links...

  19. The Ends of Revolution

    Haugbølle, Sune; Bandak, Andreas

    2017-01-01

    from the days of Tahrir Square in early 2011, when people with elated spirits poured into the streets to demand a better political future. If the large-scale social mobilization back then provided the best refutation of Francis Fukuyama’s the end of history thesis then the failure to translate...

  20. Life's end: Ethnographic perspectives.

    Goodwin-Hawkins, Bryonny; Dawson, Andrew

    2018-01-01

    In this introduction to the special issue, Life's End: Ethnographic Perspectives, we review the field of anthropological studies of death and dying. We make the argument that, largely because of its sub-disciplining into the larger field of the anthropology of religion, ritual and symbolism, the focus of anthropological research on death has been predominantly on post- rather than pre-death events, on death's beginnings rather than life's ends. Additionally, we argue that an anthropological aversion to the study of dying may also lie in the intimacy of the discipline's principal method, ethnography. Contrastingly, we argue that this very methodological intimacy can be a source of insight, and we offer this as a rationale for the special issue as a whole, which comprises eight ethnographic studies of dying and social relations at life's end from across Africa, Australia, Europe, and North America. Each of these studies is then summarized, and a rationale for their presentation around the themes of "structures of dying," "care for the dying," "hope in dying," and "ending life" is presented.

  1. When Strategy Ends

    Vestenskov, David; Jørgensen, Lars Wille

    2014-01-01

    This chapter deals with the end of strategy, that is, conflict termination and how strategic achievements are measured and evaluated. It claims that the modern intervention of choice by NATO and its allies are transformation wars and challenges the concept of victory in such wars. Through a compa...

  2. End Ordovician extinctions

    Harper, David A. T.; Hammarlund, Emma; Rasmussen, Christian M. Ø.

    2014-01-01

    -global anoxia associated with a marked transgression during the Late Hirnantian. Most recently, however, new drivers for the extinctions have been proposed, including widespread euxinia together with habitat destruction caused by plate tectonic movements, suggesting that the end Ordovician mass extinctions were...

  3. Virksomhedscensur farligere end selvcensur

    Brink, Dennis Meyhoff

    2010-01-01

    Når TV-stationer som SBS og auktionshuse som lauritz.com ikke tør vise provokerende materiale, så er der ikke tale om selvcensur, men om virksomhedscensur. Og det er langt farligere end selvcensur....

  4. Lung counting: Comparison of a four detector array that has either metal or carbon fiber end caps, and the effect on array performance characteristics

    Sabbir Ahmed, Asm; Kramer, Gary H.

    2011-01-01

    This study described the performance of an array of HPGe detectors, made by ORTEC. In the existing system, a metal end cap was used in the detector construction. In general, the natural metal contains some radioactive materials, create high background noises and signals during in vivo counting. ORTEC proposed a novel carbon fiber to be used in end cap, without any radio active content. This paper described the methodology of developing a model of the given HPGe array-detectors, comparing the detection efficiency and cross talk among the detectors using two end cap materials: either metal or carbon fiber and to provide a recommendation about the end cap material. The detector's counting efficiency were studied using point and plane sources. The cross talk among the array detectors were studied using a homogeneous attenuating medium made of tissue equivalent material. The cross talk was significant when single or multiple point sources (simulated to heterogeneous hot spots) were embedded inside the attenuating medium. With carbon fiber, the cross talk increased about 100% for photon energy at about 100 keV. For a uniform distribution of radioactive material, the cross talk increased about 5-10% when the end cap was made of carbon instead of steel. Metal end cap was recommended for the array of HPGe detectors.

  5. End-to-end learning for digital hologram reconstruction

    Xu, Zhimin; Zuo, Si; Lam, Edmund Y.

    2018-02-01

    Digital holography is a well-known method to perform three-dimensional imaging by recording the light wavefront information originating from the object. Not only the intensity, but also the phase distribution of the wavefront can then be computed from the recorded hologram in the numerical reconstruction process. However, the reconstructions via the traditional methods suffer from various artifacts caused by twin-image, zero-order term, and noise from image sensors. Here we demonstrate that an end-to-end deep neural network (DNN) can learn to perform both intensity and phase recovery directly from an intensity-only hologram. We experimentally show that the artifacts can be effectively suppressed. Meanwhile, our network doesn't need any preprocessing for initialization, and is comparably fast to train and test, in comparison with the recently published learning-based method. In addition, we validate that the performance improvement can be achieved by introducing a prior on sparsity.

  6. Effect of difference in occlusal contact area of mandibular free-end edentulous area implants on periodontal mechanosensitive threshold of adjacent premolars.

    Terauchi, Rie; Arai, Korenori; Tanaka, Masahiro; Kawazoe, Takayoshi; Baba, Shunsuke

    2015-01-01

    Implant treatment is believed to cause minimal invasion of remaining teeth. However, few studies have examined teeth adjacent to an implant region. Therefore, this study investigated the effect of occlusal contact size of implants on the periodontal mechanosensitive threshold of adjacent premolars. A cross-sectional study design was adopted. The Department of Oral Implantology, Osaka Dental University, was the setting where patients underwent implant treatment in the mandibular free-end edentulous area. The study population comprised of 87 patients (109 teeth) who underwent follow-up observation for at least 3 years following implant superstructure placement. As variables, age, sex, duration following superstructure placement, presence or absence of dental pulp, occlusal contact area, and periodontal mechanosensitive threshold were considered. The occlusal contact area was measured using Blue Silicone(®)and Bite Eye BE-I(®). Periodontal mechanosensitive threshold were measured using von Frey hair. As quantitative variables for periodontal mechanosensitive threshold, we divided subjects into two groups: normal (≤5 g) and high (≥5.1 g). For statistical analysis, we compared the two groups for the sensation thresholds using the Chi square test for categorical data and the Mann-Whitney U test for continuous volume data. For variables in which a significant difference was noted, we calculated the odds ratio (95 % confidence interval) and the effective dose. There were 93 teeth in the normal group and 16 teeth in the high group based on periodontal mechanosensitive threshold. Comparison of the two groups indicated no significant differences associated with age, sex, duration following superstructure placement, or presence or absence of dental pulp. A significant difference was noted with regard to occlusal contact area, with several high group subjects belonging to the small contact group (odds ratio: 4.75 [1.42-15.87]; effective dose: 0.29). The results of

  7. Effects of positive end-expiratory pressure titration and recruitment maneuver on lung inflammation and hyperinflation in experimental acid aspiration-induced lung injury.

    Ambrosio, Aline M; Luo, Rubin; Fantoni, Denise T; Gutierres, Claudia; Lu, Qin; Gu, Wen-Jie; Otsuki, Denise A; Malbouisson, Luiz M S; Auler, Jose O C; Rouby, Jean-Jacques

    2012-12-01

    In acute lung injury positive end-expiratory pressure (PEEP) and recruitment maneuver are proposed to optimize arterial oxygenation. The aim of the study was to evaluate the impact of such a strategy on lung histological inflammation and hyperinflation in pigs with acid aspiration-induced lung injury. Forty-seven pigs were randomly allocated in seven groups: (1) controls spontaneously breathing; (2) without lung injury, PEEP 5 cm H2O; (3) without lung injury, PEEP titration; (4) without lung injury, PEEP titration + recruitment maneuver; (5) with lung injury, PEEP 5 cm H2O; (6) with lung injury, PEEP titration; and (7) with lung injury, PEEP titration + recruitment maneuver. Acute lung injury was induced by intratracheal instillation of hydrochloric acid. PEEP titration was performed by incremental and decremental PEEP from 5 to 20 cm H2O for optimizing arterial oxygenation. Three recruitment maneuvers (pressure of 40 cm H2O maintained for 20 s) were applied to the assigned groups at each PEEP level. Proportion of lung inflammation, hemorrhage, edema, and alveolar wall disruption were recorded on each histological field. Mean alveolar area was measured in the aerated lung regions. Acid aspiration increased mean alveolar area and produced alveolar wall disruption, lung edema, alveolar hemorrhage, and lung inflammation. PEEP titration significantly improved arterial oxygenation but simultaneously increased lung inflammation in juxta-diaphragmatic lung regions. Recruitment maneuver during PEEP titration did not induce additional increase in lung inflammation and alveolar hyperinflation. In a porcine model of acid aspiration-induced lung injury, PEEP titration aimed at optimizing arterial oxygenation, substantially increased lung inflammation. Recruitment maneuvers further improved arterial oxygenation without additional effects on inflammation and hyperinflation.

  8. Cost-effectiveness of left ventricular assist devices for patients with end-stage heart failure: analysis of the French hospital discharge database.

    Tadmouri, Abir; Blomkvist, Josefin; Landais, Cécile; Seymour, Jerome; Azmoun, Alexandre

    2018-02-01

    Although left ventricular assist devices (LVADs) are currently approved for coverage and reimbursement in France, no French cost-effectiveness (CE) data are available to support this decision. This study aimed at estimating the CE of LVAD compared with medical management in the French health system. Individual patient data from the 'French hospital discharge database' (Medicalization of information systems program) were analysed using Kaplan-Meier method. Outcomes were time to death, time to heart transplantation (HTx), and time to death after HTx. A micro-costing method was used to calculate the monthly costs extracted from the Program for the Medicalization of Information Systems. A multistate Markov monthly cycle model was developed to assess CE. The analysis over a lifetime horizon was performed from the perspective of the French healthcare payer; discount rates were 4%. Probabilistic and deterministic sensitivity analyses were performed. Outcomes were quality-adjusted life years (QALYs) and incremental CE ratio (ICER). Mean QALY for an LVAD patient was 1.5 at a lifetime cost of €190 739, delivering a probabilistic ICER of €125 580/QALY [95% confidence interval: 105 587 to 150 314]. The sensitivity analysis showed that the ICER was mainly sensitive to two factors: (i) the high acquisition cost of the device and (ii) the device performance in terms of patient survival. Our economic evaluation showed that the use of LVAD in patients with end-stage heart failure yields greater benefit in terms of survival than medical management at an extra lifetime cost exceeding the €100 000/QALY. Technological advances and device costs reduction shall hence lead to an improvement in overall CE. © 2017 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

  9. Effects of inhalational anaesthesia with low tidal volume ventilation on end-tidal sevoflurane and carbon dioxide concentrations: prospective randomized study.

    de la Matta-Martín, M; López-Herrera, D; Luis-Navarro, J C; López-Romero, J L

    2014-02-01

    We investigated how ventilation with low tidal volumes affects the pharmacokinetics of sevoflurane uptake during the first minutes of inhaled anaesthesia. Forty-eight patients scheduled for lung resection were randomly assigned to three groups. Patients in group 1, 2 and 3 received 3% sevoflurane for 3 min via face mask and controlled ventilation with a tidal volume of 2.2, 8 and 12 ml kg(-1), respectively (Phase 1). After tracheal intubation (Phase 2), 3% sevoflurane was supplied for 2 min using a tidal volume of 8 ml kg(-1) (Phase 3). End-tidal sevoflurane concentrations were significantly higher in group 1 at the end of phase 1 and lower at the end of phase 2 than in the other groups as follows: median of 2.5%, 2.2% and 2.3% in phase 1 for groups 1, 2 and 3, respectively (Ptidal carbon dioxide values in group 1 were significantly lower at the end of phase 1 and higher at the end of phase 2 than in the other groups as follows: median of 16.5, 31 and 29.5 mm Hg in phase 1 for groups 1, 2 and 3, respectively (Ptidal volume approximating the airway dead space volume, end-tidal sevoflurane and end-tidal carbon dioxide may not correctly reflect the concentration of these gases in the alveoli, leading to misinterpretation of expired gas data. Copyright © 2013 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España. All rights reserved.

  10. Effect of breathing fluctuations on cerebral blood flow in demented patients and its correction method using end-tidal CO/sub 2/ concentration

    Komatani, Akio; Yamaguchi, Koichi; Kera, Masahiro; Takanashi, Toshiyasu; Shinohara, Masao; Kawakatsu, Shinobu; Yazaki, Mitsuyasu

    1989-02-01

    During mouthpiece respiration of Xe-133 for a measurement of regional cerebral blood flow (rCBF), the breathing pattern of patients fluctuated and it caused a change of end-tidal CO/sub 2/ concentration that had an excellent correlation with PaCO/sub 2/ in patients without respiratory disease. The end-tidal CO/sub 2/ concentration of demented patients varied within lower ranges than senile control group. The range of fluctuation on the end-tidal CO/sub 2/ concentration was dependent on the type and the degree of dementia, and it fluctuated most widely at the middle stage of Alzheimer disease. Mean cerebral blood flow increased by 13.9% for each l% increase in end-tidal CO/sub 2/ concentration (3.6%/mmHg PaCO/sub 2/) in the case of demented patients without cerebrovascular disease. To improve the reliability of rCBF in demented patients, especially in Alzheimer disease, the correction of rCBF data for end-tidal CO/sub 2/ concentration should be performed.

  11. Effective peer-to-peer support for young people with end-stage renal disease: a mixed methods evaluation of Camp COOL

    2013-01-01

    Background The Camp COOL programme aims to help young Dutch people with end-stage renal disease (ESRD) develop self-management skills. Fellow patients already treated in adult care (hereafter referred to as ‘buddies’) organise the day-to-day program, run the camp, counsel the attendees, and also participate in the activities. The attendees are young people who still have to transfer to adult care. This study aimed to explore the effects of this specific form of peer-to-peer support on the self-management of young people (16–25 years) with ESRD who participated in Camp COOL (CC) (hereafter referred to as ‘participants’). Methods A mixed methods research design was employed. Semi-structured interviews (n = 19) with initiators/staff, participants, and healthcare professionals were conducted. These were combined with retrospective and pre-post surveys among participants (n = 62), and observations during two camp weeks. Results Self-reported effects of participants were: increased self-confidence, more disease-related knowledge, feeling capable of being more responsible and open towards others, and daring to stand up for yourself. According to participants, being a buddy or having one positively affected them. Self-efficacy of attendees and independence of buddies increased, while attendees’ sense of social inclusion decreased (measured as domains of health-related quality of life). The buddy role was a pro-active combination of being supervisor, advisor, and leader. Conclusions Camp COOL allowed young people to support each other in adjusting to everyday life with ESRD. Participating in the camp positively influenced self-management in this group. Peer-to-peer support through buddies was much appreciated. Support from young adults was not only beneficial for adolescent attendees, but also for young adult buddies. Paediatric nephrologists are encouraged to refer patients to CC and to facilitate such initiatives. Together with nephrologists in adult

  12. Laggards No More: Understanding Effective Use of Information and Communication Technologies by West Virginian Women at the Lower End of the Digital Divide

    Goh, Debbie

    2010-01-01

    Despite efforts to introduce information and communication technologies to women, internet access rates for women and the benefits they can draw from using ICTs still are not on par with men. This dissertation examines why the gender digital divide persists in America, who are the women at the lower end of the digital divide, and why they are…

  13. Burning of MOX fuels in LWRs; fuel history effects on thermal properties of hull and end piece wastes and the repository performance

    Hirano, Fumio; Sato, Seichi; Kozaki, Tamotsu

    2012-01-01

    The thermal impacts of hull and end piece wastes from the reprocessing of MOX spent fuels burned in LWRs on repository performance were investigated. The heat generation rates in MOX spent fuels and the resulting heat generation rates in hull and end piece wastes change depending on the history of MOX fuels. This history includes the burn-up of UO 2 spent fuels from which the Pu is obtained, the cooling period before reprocessing, the storage period of fresh MOX fuels before being loaded into an LWR, as well as the burn-up of the MOX fuels. The heat generation rates in hull and end piece wastes from the reprocessing of MOX spent fuels with any of those histories are significantly larger than those from UO 2 spent fuels with burn-ups of 45 GWd/THM. If a temperature below 80degC is specified for cement-based materials used in waste packages after disposal, the allowable number of canisters containing compacted hull and end pieces in a package for 45 and 70 GWd-MOX needs to be limited to a value of 0.4-1.6, which is significantly lower than 4.0 for 45 GWd-UO 2 . (author)

  14. Towards a new curriculum to support the changing front end innovation landscape : Educating engineering students to effectively participate in iterative data-enabled product development processes

    van Kollenburg, J.W.M.; Jeedella, Shawhkat Y.; van Kollenburg, P.A.M.; Kargas, Sotirios

    The new generation of Internet of Things product offers exciting opportunities to design and develop highly personal and adaptive products. Engineering students are traditionally not trained to use user data, generated by prototypes, as creative material for ideating the Fuzzy Front End phase of the

  15. Opportunities for exercise during pullet rearing, Part II: Long-term effects on bone characteristics of adult laying hens at the end-of-lay.

    Casey-Trott, T M; Korver, D R; Guerin, M T; Sandilands, V; Torrey, S; Widowski, T M

    2017-08-01

    Osteoporosis in laying hens has been a production and welfare concern for several decades. The objective of this study was to determine whether differing opportunities for exercise during pullet rearing influences long-term bone quality characteristics in end-of-lay hens. A secondary objective was to assess whether differing opportunities for exercise in adult housing systems alters bone quality characteristics in end-of-lay hens. Four flock replicates of 588 Lohmann Selected Leghorn-Lite pullets were reared in either conventional cages (Conv) or an aviary rearing system (Avi) and placed into conventional cages (CC), 30-bird furnished cages (FC-S), or 60-bird furnished cages (FC-L) for adult housing. Wing and leg bones were collected at the end-of-lay to quantify bone composition and strength using quantitative computed tomography and bone breaking strength (BBS). At the end-of-lay, Avi hens had greater total and cortical cross-sectional area (P lay. © The Author 2017. Published by Oxford University Press on behalf of Poultry Science Association.

  16. Analysis of the Effect of Channel Leakage on Design, Characterization and Modelling of a High Voltage Pseudo-Floating Gate Sensor-Front-End

    Luca Marchetti

    2017-10-01

    Full Text Available In this paper, we analyze the effects of channel leakage on the design, modelling and characterization of a high voltage pseudo-floating gate amplifier (PFGA used as sensor front-end. Leakages are known as a major challenge in new modern CMOS technologies, which are used to bias the PFGA, and consequently affect the behavior of the amplifier. As high voltages are desired for actuation of many types of resonating sensors, especially in ultrasound applications, PFGA implemented in high voltage and low leakage technologies, such as older CMOS fabrication processes or power MOSFET can be the only option. The challenge with these technologies used to implement the PFGA is that the leakages are very low, which affect the biasing of the floating gate. However, the numerous advantages of this type of amplifier, implemented with modern fabrication processes, such as high flexibility, compactness, low power consumption , etc. encouraged the authors to research about this topic. This work provides analysis of the working principle and the design rules for this amplifier, emphasizing the major differences between PFGA implemented in low leakage and high leakage technologies. Static and dynamic analysis, input offset and non-linearity of the PFGA are the main topics of this article. Three different design approaches are presented in this paper, in order to provide a more general design procedure and offset compensation for any low leakage PFGA. The amplifier has been simulated in AMS- 0 . 35 μ m CMOS models for supply voltages of 5 V and 10 V. Two prototypes have been realized to verify the validity of the modelling and the simulation results. Both devices have been realized by using discrete components and mounted on a printed circuit board. In this work, MOSFETs are realized by using commercial IC CD4007UB and 2N7000. Measurement results of the first prototype proved that the implementation of a low leakage PFGA is possible after that the input offset of

  17. Nurse-perceived barriers to effective communication regarding prognosis and optimal end-of-life care for surgical ICU patients: a qualitative exploration.

    Aslakson, Rebecca A; Wyskiel, Rhonda; Thornton, Imani; Copley, Christina; Shaffer, Dauryne; Zyra, Marylou; Nelson, Judith; Pronovost, Peter J

    2012-08-01

    Integration of palliative care for intensive care unit (ICU) patients is important but often challenging, especially in surgical ICUs (SICUs), in part because many surgeons equate palliative care with terminal care and failure of restorative care. SICU nurses, who are key front-line clinicians, can provide insights into barriers for delivery of optimal palliative care in their setting. We developed a focus group guide to identify barriers to two key components of palliative care-optimal communication regarding prognosis and optimal end-of-life care-and used the tool to conduct focus groups of nurses providing bedside care in three SICUs at a tertiary care, academic, inner city hospital. Using content analysis technique, responses were organized into thematic domains that were validated by independent observers and a subset of participating nurses. Four focus groups included a total of 32 SICU nurses. They identified 34 barriers to optimal communication regarding prognosis, which were summarized into four domains: logistics, clinician discomfort with discussing prognosis, inadequate skill and training, and fear of conflict. For optimal end-of-life care, the groups identified 24 barriers in four domains: logistics, inability to acknowledge an end-of-life situation, inadequate skill and training, and cultural differences relating to end-of-life care. Nurses providing bedside care in SICUs identify barriers in several domains that may impede optimal discussions of prognoses and end-of-life care for patients with surgical critical illness. Consideration of these perceived barriers and the underlying SICU culture is relevant for designing interventions to improve palliative care in this setting.

  18. Conflict Termination: Every Conflict Must End

    Garza, Mario

    1997-01-01

    .... The operational commander and his staff must understand the nature of conflict termination and the post-conflict activities so that they will be able to effectively translate the desired end state...

  19. The Effect of Uncertain End-of-Life Product Quality and Consumer Incentives on Partial Disassembly Sequencing in Value Recovery Operations

    Rickli, Jeremy Lewis

    2013-01-01

    This dissertation addresses gaps in the interaction between End-of-Life (EoL) product acquisition systems and disassembly sequencing. The research focuses on two remanufacturing research problems; 1) modeling uncertain EoL product quality, quantity, and timing in regards to EoL product acquisition and disassembly sequencing and 2) designing EoL product acquisition schemes considering EoL product uncertainty. The main research objectives within these areas are; analyzing, predicting, and contr...

  20. Lower end fitting debris collector and end cap spacer grid

    Bryan, W.J.

    1990-01-01

    This patent describes a nuclear reactor having fuel assemblies including an upper end fitting and spaced nuclear fuel rod spacer grids for supporting and spacing a plurality of elongated nuclear fuel rods. Each includes a hollow active portion of nuclear fuel filled cladding intermediate the rod ends and tapering end cap of solid material with a circumferential groove on the rod end which first encounters reactor coolant flow, a lower end filtering debris collector and end cap spacer grid for capturing and retaining deleterious debris carried by reactor coolant before it enters the active region of a fuel assembly and creates fuel rod cladding damage

  1. Brachistochrones with loose ends

    Mertens, Stephan; Mingramm, Sebastian [Institut fuer Theoretische Physik, Otto-von-Guericke Universitaet, PF 4120, 39016 Magdeburg (Germany)

    2008-11-15

    The classical problem of the brachistochrone asks for the curve down which a body sliding from rest and accelerated by gravity will slip (without friction) from one point to another in least time. In undergraduate courses on classical mechanics, the solution of this problem is the primary example of the power of variational calculus. Here, we address the generalized brachistochrone problem that asks for the fastest sliding curve between a point and a given curve or between two given curves. The generalized problem can be solved by considering variations with varying end points. We will contrast the formal solution with a much simpler solution based on symmetry and kinematic reasoning. Our exposition should encourage teachers to include variational problems with free boundary conditions in their courses and students to try simple, intuitive solutions first.

  2. Sealing a conduit end

    Mentz, R.M.

    1993-01-01

    An apparatus for sealing or blocking conduits, such as the primary nozzles of a nuclear steam generator is described. It includes an annular bracket sealingly attached to the open end of the nozzle, the bracket having a plurality of threaded holes therein. Mounted atop the bracket is a generally circular nozzle dam for covering the opening. Interposed between the nozzle dam and the bracket is an extrusion-resistant seal member having a plurality of apertures therethrough for receiving each bolt. The seal member is configured to resist extrusion by having laminated layers of differing hardnesses, so that the seal member will not laterally extrude away from each bolt in a manner that enlarges the aperture surrounding each bolt as the nozzle dam is bolted to the bracket. (author)

  3. End-to-side and end-to-end anastomoses give similar results in cervical oesophagogastrostomy.

    Pierie, J P; De Graaf, P W; Poen, H; Van Der Tweel, I; Obertop, H

    1995-12-01

    To find out if there were any differences in healing between end-to-end and end-to-side anastomoses for oesophagogastrostomy. Open study with historical controls. University hospital, The Netherlands. 28 patients with end-to-end and 90 patients with end-to-side anastomoses after transhiatal oesophagectomy and partial gastrectomy for cancer of the oesophagus or oesophagogastric junction, with gastric tube reconstruction and cervical anastomosis. Leak and stricture rates, and the number of dilatations needed to relieve dysphagia. There were no significant differences in leak rates (end-to-end 4/28, 14%, and end-to-side 13/90, 14%) or anastomotic strictures (end-to-end 9/28, 32%, and end-to-side 26/90, 29%). The median number of dilatations needed to relieve dysphagia was 7 (1-33) after end-to-end and 9 (1-113) after end-to-side oesophagogastrostomy. There were no differences between the two methods of suture of cervical oesophagogastrostomy when leakage, stricture, and number of dilatations were used as criteria of good healing.

  4. The Effect of Calcium and Available Phosphorus Levels on Performance, Egg Quality and Bone Characteristics of Japanese Quails at End of the Egg-Production Phase

    CLN Ribeiro

    Full Text Available ABSTRACT Calcium (Ca and available phosphorus (avP requirements for egg production are different between the beginning and the end of the egg-production cycle. The objective of this study was to estimate the Ca and avP requirements of Japanese quails at end of the production phase. In total, 256 Japanese quails with 48 weeks of age were randomly distributed in 2 x 2 factorial arrangement consisting of two Ca levels (29 and 38 g/kg and two avP levels (1.5 and 3.0 g/kg, totaling four treatments with eight replicates of eight hens each. The variables evaluated were feed intake (FI; egg production (EP; marketable egg production (MEP; egg weight (EW; egg mass (EM; feed conversion ratio per egg mass (FCRM; feed conversion ratio per dozen eggs (FCRD; livability (L; yolk weight (YW, albumen weight (AW, eggshell weight (SW; yolk percentage (YP, albumen percentage (AP, eggshell percentage (SP, specific egg weight (SEW; bone calcium percentage (BCa, bone phosphorus percentage (BP, bone ash weight (Bash and bone ash percentage (PBash. There was no interaction between Ca and avP levels for any of the evaluated parameters, except for SEW. Quail performance was not influenced by the treatments, except for MEP. Bone characteristics were not influenced by the tested dietary Ca and avP levels. However, SW and SP increased and AP decreased as dietary Ca level increased. The dietary supplementation of 38 g Ca/kg and 3.0 g avP/kg may increase marketable egg production and the egg quality of Japanese quails at end of the production cycle.

  5. Minimal clinically important difference and the effect of clinical variables on the ankle osteoarthritis scale in surgically treated end-stage ankle arthritis.

    Coe, Marcus P; Sutherland, Jason M; Penner, Murray J; Younger, Alastair; Wing, Kevin J

    2015-05-20

    There is much debate regarding the best outcome tool for use in foot and ankle surgery, specifically in patients with ankle arthritis. The Ankle Osteoarthritis Scale (AOS) is a validated, disease-specific score. The goals of this study were to investigate the clinical performance of the AOS and to determine a minimal clinically important difference (MCID) for it, using a large cohort of 238 patients undergoing surgery for end-stage ankle arthritis. Patients treated with total ankle arthroplasty or ankle arthrodesis were prospectively followed for a minimum of two years at a single site. Data on demographics, comorbidities, AOS score, Short Form-36 results, and the relationship between expectations and satisfaction were collected at baseline (preoperatively), at six and twelve months, and then yearly thereafter. A linear regression analysis examined the variables affecting the change in AOS scores between baseline and the two-year follow-up. An MCID in the AOS change score was then determined by employing an anchor question, which asked patients to rate their relief from symptoms after surgery. Surgical treatment of end-stage ankle arthritis resulted in a mean improvement (and standard deviation) of 31.2 ± 22.7 points in the AOS score two years after surgery. The MCID of the AOS change score was a mean of 28.0 ± 17.9 points. The change in AOS score was significantly affected by the preoperative AOS score, smoking, back pain, and age. Patients undergoing arthroplasty or arthrodesis for end-stage ankle arthritis experienced a mean improvement in AOS score that was greater than the estimated MCID (31.2 versus 28.0 points). Copyright © 2015 by The Journal of Bone and Joint Surgery, Incorporated.

  6. Effect of fluid loading on left ventricular volume and stroke volume variability in patients with end-stage renal disease: a pilot study

    Kanda, Hirotsugu; Hirasaki, Yuji; Iida, Takafumi; Kanao-Kanda, Megumi; Toyama, Yuki; Kunisawa, Takayuki; Iwasaki, Hiroshi

    2015-01-01

    Purpose The aim of this study was to investigate fluid loading-induced changes in left ventricular end-diastolic volume (LVEDV) and stroke volume variability (SVV) in patients with end-stage renal disease (ESRD) using real-time three-dimensional transesophageal echocardiography and the Vigileo-FloTrac system. Patients and methods After obtaining ethics committee approval and informed consent, 28 patients undergoing peripheral vascular procedures were studied. Fourteen patients with ESRD on hemodialysis (HD) were assigned to the HD group and 14 patients without ESRD were assigned to the control group. Institutional standardized general anesthesia was provided in both groups. SVV was measured using the Vigileo-FloTrac system. Simultaneously, a full-volume three-dimensional transesophageal echocardiography dataset was acquired to measure LVEDV, left ventricular end-systolic volume, and left ventricular ejection fraction. Measurements were obtained before and after loading 500 mL hydroxyethyl starch over 30 minutes in both groups. Results In the control group, intravenous colloid infusion was associated with a significant decrease in SVV (13.8%±2.6% to 6.5%±2.6%, P<0.001) and a significant increase in LVEDV (83.6±23.4 mL to 96.1±28.8 mL, P<0.001). While SVV significantly decreased after infusion in the HD group (16.2%±6.0% to 6.2%±2.8%, P<0.001), there was no significant change in LVEDV. Conclusion Our preliminary data suggest that fluid responsiveness can be assessed not by LVEDV but also by SVV due to underlying cardiovascular pathophysiology in patients with ESRD. PMID:26527879

  7. The effect of dignity therapy on distress and end-of-life experience in terminally ill patients: a randomised controlled trial

    Chochinov, Harvey Max; Kristjanson, Linda J.; Breitbart, William; McClement, Susan; Hack, Thomas F; Hassard, Tom; Harlos, Mike

    2011-01-01

    Objectives Dignity Therapy is a unique, individualized, brief psychotherapy, developed for patients (and their families) living with life threatening or life limiting illness. The purpose of this study was to determine if Dignity Therapy could mitigate distress and/or bolster end-of-life experience for patients nearing death. Trial Design Multi-site randomized controlled trial, with patients assigned to Dignity Therapy, Client Centred Care or Standard Palliative Care. Study arm assignment was based on a computer-generated table of random numbers. Blinding was achieved using opaque sealed envelopes, containing allocations that were only opened once consent had been obtained. Participants Patients receiving hospital or community (hospice or home) based palliative care, in Winnipeg, New York, or Perth, randomly assigned to, Dignity Therapy [n=108], Client Centered Care [n=107] and Standard Palliative Care (n=111). Main Outcome Measures The primary outcome measures included the FACIT Spiritual Well-Being Scale, the Patient Dignity Inventory, the Hospital Anxiety and Depression Scale; items from the Structured Interview for Symptoms and Concerns, the Quality of Life Scale and a modified Edmonton Symptom Assessment Scale. Mean changes between baseline and end of intervention ratings were determined. Secondary outcomes, examining self-report end-of-life experience, consisted of a post-study survey administered across all study arms. Intervention Dignity Therapy, a novel, brief psychotherapy, provides patients with life threatening and life limiting illnesses an opportunity to speak about things that matter most to them. These recorded conversations form the basis of a generativity document, which patients can bequeath to individuals of their choosing. Client Centred Care is a supportive psychotherapeutic approach, in which research nurse/therapists guide patients through discussions focusing on here and now issues. Findings No significant differences across study arms

  8. Effects of reflector and crystal surface on the performance of a depth-encoding PET detector with dual-ended readout

    Ren, Silin; Yang, Yongfeng; Cherry, Simon R.

    2014-01-01

    Purpose: Depth encoding detectors are required to improve the spatial resolution and spatial resolution uniformity of small animal positron emission tomography (PET) scanners, as well as dedicated breast and brain scanners. Depth of interaction (DOI) can be measured by using dual-ended readout of lutetium oxyorthosilicate (LSO) scintillator arrays with position-sensitive avalanche photodiodes. Inter-crystal reflectors and crystal surface treatments play important roles in determining the performance of dual-ended detectors. In this paper, the authors evaluated five LSO arrays made with three different intercrystal reflectors and with either polished or unpolished crystal surfaces. Methods: The crystal size in all arrays was 1.5 mm, which is typical of the detector size used in small animal and dedicated breast scanners. The LSO arrays were measured with dual-ended readout and were compared in terms of flood histogram, energy resolution, and DOI resolution performance. Results: The four arrays using enhanced specular reflector (ESR) and Toray reflector provided similar quality flood histograms and the array using Crystal Wrap reflector gave the worst flood histogram. The two arrays using ESR reflector provided the best energy resolution and the array using Crystal Wrap reflector yielded the worst energy resolution. All arrays except the polished ESR array provided good DOI resolution ranging from 1.9 mm to 2.9 mm. DOI resolution improved as the gradient in light collection efficiency with depth (GLCED) increased. The geometric mean energies were also calculated for these dual-ended readout detectors as an alternative to the conventional summed total energy. It was shown that the geometric mean energy is advantageous in that it provides more uniform photopeak amplitude at different depths for arrays with high GLCED, and is beneficial in event selection by allowing a fixed energy window independent of depth. A new method of DOI calculation that improved the linearity

  9. Politics at its end

    Proske, R.

    1992-01-01

    The author sees politics describing towards its end under the impact of the development science, technology and the economy have undergone. One of the signposts on this road of change has been the discovery of nuclear fission, leading to a revolution in the field of science, and developments such as the atomic bomb and, later on, the peaceful uses of nuclear energy, with technological development contributing the safe and economically operating reactors for power generation. In the eyes of the author, politics has little to contribute to solving the biggest problems of the future, which are the population explosion, and the global climate change caused by man-made emissions of trace gases. In order to tackle the climate problem, there is urgent need for a drastic outback in the consumption of fossil fuels, although renewable energy sources have not yet become reality to count on, the hydrogen economy still being just a hope, - so that nuclear power may be gaining second wind. (HP) [de

  10. Orbital maneuvering end effectors

    Myers, W. Neill (Inventor); Forbes, John C. (Inventor); Barnes, Wayne L. (Inventor)

    1986-01-01

    This invention relates to an end effector device for grasping and maneuvering objects such as berthing handles of a space telescope. The device includes a V-shaped capture window defined as inclined surfaces in parallel face plates which converge toward a retainer recess in which the handle is retained. A pivotal finger (30) meshes with a pair of pivoted fingers which rotate in counterrotation. The fingers rotate to pull a handle within the capture window into recess where latches lock handle in the recess. To align the capture window, plates may be cocked plus or minus five degrees on base. Drive means is included in the form of a motor coupled with a harmonic drive speed reducer, which provides for slow movement of the fingers at a high torque so that large articles may be handled. Novelty of the invention is believed to reside in the combined intermeshing finger structure, drive means and the harmonic drive speed reducer, which features provide the required maneuverability and strength.

  11. Youth in Dead End

    Duygu TANRIKULU

    2011-01-01

    Full Text Available The primary factor to ensure economic and social development and also to build a healthy society is the education system which plays a significant role in human capital formation and shapes the social structure and its outputs. In this context, there are some risks threatening the youth that is trying to position itself on the education-employment line and some critical areas in need of national policy intervention as well. Hence, by analyzing indicators on education and labor force, this study aims to reveal the amount of youth under risk and to identify these critical areas, while targeting to highlight the urgent need for policy development focusing on youth in dead end. Within the study, it is emphasized that the education system causes youth to face with the problems of access and quality, and that there is a significant amount of youth not in education and employment, while underlining the necessity of bringing especially this inactive youth in economy in addition to equipping with required qualifications for their active participation in social life. Thus, in order to hinder human capital loss additionally, there is policy need in two directions, as focusing on the education system to prevent new hopeless generations on the one hand, and on the inclusion of the disadvantaged youth on the other.

  12. Curvaton and the inhomogeneous end of inflation

    Assadullahi, Hooshyar; Wands, David; Firouzjahi, Hassan; Namjoo, Mohammad Hossein

    2012-01-01

    We study the primordial density perturbations and non-Gaussianities generated from the combined effects of an inhomogeneous end of inflation and curvaton decay in hybrid inflation. This dual role is played by a single isocurvature field which is massless during inflation but acquire a mass at the end of inflation via the waterfall phase transition. We calculate the resulting primordial non-Gaussianity characterized by the non-linearity parameter, f NL , recovering the usual end-of-inflation result when the field decays promptly and the usual curvaton result if the field decays sufficiently late

  13. Pharmacotherapy at the end-of-life.

    O'Mahony, Denis

    2011-07-01

    Older people reaching end-of-life status are particularly at risk from inter-related adverse effects of pharmacotherapy, including polypharmacy, inappropriate medications and adverse drug events. These adverse effects of pharmacotherapy may be highly detrimental, as well as highly expensive. End-of-life pharmacotherapy is sometimes perceived to be complex and challenging, probably unnecessarily. This relates in part to the poorly developed evidence base and lack of high-quality research in this area. In this article, we deal with some of the key issues relating to pharmacotherapy in end-of-life patients, namely (i) the guiding principles of drug selection, (ii) the main drugs and drug classes that are best avoided, (iii) the benefits of \\'oligopharmacy\\' (i.e. deliberate avoidance of polypharmacy) in end-of-life patients.

  14. Demonstration of possible causes and effects of extinction by the end of the Permian period through the analysis of δ13C

    Monge Montero, Carmen

    2012-01-01

    The application of chemistry in different sciences has been critical to understand events and find solutions to possible problems in the future. Geochemistry and chemical analysis methods have helped to track changes in δ 13 C and have provided greater understanding of events of great importance; such as mass extinctions over millions of years, especially the largest of all the end of the Permian period. Analysis is performed on the amount of δ 13 C with geochemical parameters and comparison between different stratigraphic zones. The possible evidence of volcanism as a contributor to the great extinction are discussed and overproduction of species in surface waters after her, that has ended delaying the recovery of biotic life in the early Triassic period. Tracking of δ 13 C and its relation to other tests have provided an important input to reconstruct a past million years ago; however, the assumption is always going to be in play when drawing conclusions from something happened so long ago and whose evidence may have been affected by several reasons, which is why they require much more analysis on the subject. (author) [es

  15. Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells

    Datta, Amitabha; Das, Kuheli; Sen, Chandana; Karan, Nirmal Kumar; Huang, Jui-Hsien; Lin, Chia-Her; Garribba, Eugenio; Sinha, Chittaranjan; Askun, Tulin; Celikboyun, Pinar; Mane, Sandeep B.

    2015-09-01

    Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is afforded by employing a potential monoanionic tetradentate-N2O2 Schiff base precursor (2-[{[2-(dimethylamino)ethyl]imino}methyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent CoII and CoIII ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV-vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χMT values decrease smoothly until 15 K and then reaches to the value 1.56 cm3 K mol-1 at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.

  16. The effects of end-of-day picture review and a sensor-based picture capture procedure on autobiographical memory using SenseCam.

    Finley, Jason R; Brewer, William F; Benjamin, Aaron S

    2011-10-01

    Emerging "life-logging" technologies have tremendous potential to augment human autobiographical memory by recording and processing vast amounts of information from an individual's experiences. In this experiment undergraduate participants wore a SenseCam, a small, sensor-equipped digital camera, as they went about their normal daily activities for five consecutive days. Pictures were captured either at fixed intervals or as triggered by SenseCam's sensors. On two of five nights, participants watched an end-of-day review of a random subset of pictures captured that day. Participants were tested with a variety of memory measures at intervals of 1, 3, and 8 weeks. The most fruitful of six measures were recognition rating (on a 1-7 scale) and picture-cued recall length. On these tests, end-of-day review enhanced performance relative to no review, while pictures triggered by SenseCam's sensors showed little difference in performance compared to those taken at fixed time intervals. We discuss the promise of SenseCam as a tool for research and for improving autobiographical memory.

  17. Effects of Cooking End-point Temperature and Muscle Part on Sensory 'Hardness' and 'Chewiness' Assessed Using Scales Presented in ISO11036:1994.

    Sasaki, Keisuke; Motoyama, Michiyo; Narita, Takumi; Chikuni, Koichi

    2013-10-01

    Texture and 'tenderness' in particular, is an important sensory characteristic for consumers' satisfaction of beef. Objective and detailed sensory measurements of beef texture have been needed for the evaluation and management of beef quality. This study aimed to apply the sensory scales defined in ISO11036:1994 to evaluate the texture of beef. Longissimus and Semitendinosus muscles of three Holstein steers cooked to end-point temperatures of 60°C and 72°C were subjected to sensory analyses by a sensory panel with expertise regarding the ISO11036 scales. For the sensory analysis, standard scales of 'chewiness' (9-points) and 'hardness' (7-points) were presented to the sensory panel with reference materials defined in ISO11036. As a result, both 'chewiness' and 'hardness' assessed according to the ISO11036 scales increased by increasing the cooking end-point temperature, and were different between Longissimus and Semitendinosus muscles. The sensory results were in good agreement with instrumental texture measurements. However, both texture ratings in this study were in a narrower range than the full ISO scales. For beef texture, ISO11036 scales for 'chewiness' and 'hardness' are useful for basic studies, but some alterations are needed for practical evaluation of muscle foods.

  18. Effects of Cooking End-point Temperature and Muscle Part on Sensory ‘Hardness’ and ‘Chewiness’ Assessed Using Scales Presented in ISO11036:1994

    Keisuke Sasaki

    2013-10-01

    Full Text Available Texture and ‘tenderness’ in particular, is an important sensory characteristic for consumers’ satisfaction of beef. Objective and detailed sensory measurements of beef texture have been needed for the evaluation and management of beef quality. This study aimed to apply the sensory scales defined in ISO11036:1994 to evaluate the texture of beef. Longissimus and Semitendinosus muscles of three Holstein steers cooked to end-point temperatures of 60°C and 72°C were subjected to sensory analyses by a sensory panel with expertise regarding the ISO11036 scales. For the sensory analysis, standard scales of ‘chewiness’ (9-points and ‘hardness’ (7-points were presented to the sensory panel with reference materials defined in ISO11036. As a result, both ‘chewiness’ and ‘hardness’ assessed according to the ISO11036 scales increased by increasing the cooking end-point temperature, and were different between Longissimus and Semitendinosus muscles. The sensory results were in good agreement with instrumental texture measurements. However, both texture ratings in this study were in a narrower range than the full ISO scales. For beef texture, ISO11036 scales for ‘chewiness’ and ‘hardness’ are useful for basic studies, but some alterations are needed for practical evaluation of muscle foods.

  19. Noncanonical substrate preference of lambda exonuclease for 5'-nonphosphate-ended dsDNA and a mismatch-induced acceleration effect on the enzymatic reaction.

    Wu, Tongbo; Yang, Yufei; Chen, Wei; Wang, Jiayu; Yang, Ziyu; Wang, Shenlin; Xiao, Xianjin; Li, Mengyuan; Zhao, Meiping

    2018-04-06

    Lambda exonuclease (λ exo) plays an important role in the resection of DNA ends for DNA repair. Currently, it is also a widely used enzymatic tool in genetic engineering, DNA-binding protein mapping, nanopore sequencing and biosensing. Herein, we disclose two noncanonical properties of this enzyme and suggest a previously undescribed hydrophobic interaction model between λ exo and DNA substrates. We demonstrate that the length of the free portion of the substrate strand in the dsDNA plays an essential role in the initiation of digestion reactions by λ exo. A dsDNA with a 5' non-phosphorylated, two-nucleotide-protruding end can be digested by λ exo with very high efficiency. Moreover, we show that when a conjugated structure is covalently attached to an internal base of the dsDNA, the presence of a single mismatched base pair at the 5' side of the modified base may significantly accelerate the process of digestion by λ exo. A detailed comparison study revealed additional π-π stacking interactions between the attached label and the amino acid residues of the enzyme. These new findings not only broaden our knowledge of the enzyme but will also be very useful for research on DNA repair and in vitro processing of nucleic acids.

  20. Noncanonical substrate preference of lambda exonuclease for 5′-nonphosphate-ended dsDNA and a mismatch-induced acceleration effect on the enzymatic reaction

    Yang, Yufei; Chen, Wei; Wang, Jiayu; Yang, Ziyu; Wang, Shenlin; Xiao, Xianjin; Li, Mengyuan

    2018-01-01

    Abstract Lambda exonuclease (λ exo) plays an important role in the resection of DNA ends for DNA repair. Currently, it is also a widely used enzymatic tool in genetic engineering, DNA-binding protein mapping, nanopore sequencing and biosensing. Herein, we disclose two noncanonical properties of this enzyme and suggest a previously undescribed hydrophobic interaction model between λ exo and DNA substrates. We demonstrate that the length of the free portion of the substrate strand in the dsDNA plays an essential role in the initiation of digestion reactions by λ exo. A dsDNA with a 5′ non-phosphorylated, two-nucleotide-protruding end can be digested by λ exo with very high efficiency. Moreover, we show that when a conjugated structure is covalently attached to an internal base of the dsDNA, the presence of a single mismatched base pair at the 5′ side of the modified base may significantly accelerate the process of digestion by λ exo. A detailed comparison study revealed additional π–π stacking interactions between the attached label and the amino acid residues of the enzyme. These new findings not only broaden our knowledge of the enzyme but will also be very useful for research on DNA repair and in vitro processing of nucleic acids. PMID:29490081

  1. Fundamental Flaws in the Architecture of the European Central Bank: The Possible End of the Euro Zone and its Effects to East African Community (EAC Countries

    Nothando Moyo

    2014-09-01

    Full Text Available European countries embarked on a European integration programme that saw the formation of the Euro, which has emerged as a major currency (Blair, 1999 that was introduced in 1998. With the Euro, came the establishment of the European Central Bank. Thus this study seeks to investigate the flaws in the formation of the European Central Bank that surfaced during the major economic crisis in Europe. The crisis revealing the gaps in the formation and structure of the European central bank have created major challenges for the Economic and Monetary Union (EMU. Through an extant review of literature the study will examine the East African Community Countries, investigating the ties they have to the euro zone to analyse how the crisis has affected them. Furthermore, the study will analyse what would happen to the growth patterns of the East African Countries and the various prospects they may have should the Eurozone come to an end.

  2. Mid-point for open-ended income category and the effect of equivalence scales on the income-health relationship

    Roger Keller Celeste

    2013-12-01

    Full Text Available To estimate the mid-point of an open-ended income category and to assess the impact of two equivalence scales on income-health associations. Data were obtained from the 2010 Brazilian Oral Health Survey ( Pesquisa Nacional de Saúde Bucal – SBBrasil 2010. Income was converted from categorical to two continuous variables ( per capita and equivalized for each mid-point. The median mid-point was R$ 14,523.50 and the mean, R$ 24,507.10. When per capita income was applied, 53% of the population were below the poverty line, compared with 15% with equivalized income. The magnitude of income-health associations was similar for continuous income, but categorized equivalized income tended to decrease the strength of association.

  3. Mid-point for open-ended income category and the effect of equivalence scales on the income-health relationship.

    Celeste, Roger Keller; Bastos, João Luiz

    2013-12-01

    To estimate the mid-point of an open-ended income category and to assess the impact of two equivalence scales on income-health associations. Data were obtained from the 2010 Brazilian Oral Health Survey (Pesquisa Nacional de Saúde Bucal--SBBrasil 2010). Income was converted from categorical to two continuous variables (per capita and equivalized) for each mid-point. The median mid-point was R$ 14,523.50 and the mean, R$ 24,507.10. When per capita income was applied, 53% of the population were below the poverty line, compared with 15% with equivalized income. The magnitude of income-health associations was similar for continuous income, but categorized equivalized income tended to decrease the strength of association.

  4. Standardizing an End-to-end Accounting Service

    Greenberg, Edward; Kazz, Greg

    2006-01-01

    Currently there are no space system standards available for space agencies to accomplish end-to-end accounting. Such a standard does not exist for spacecraft operations nor for tracing the relationship between the mission planning activities, the command sequences designed to perform those activities, the commands formulated to initiate those activities and the mission data and specifically the mission data products created by those activities. In order for space agencies to cross-support one another for data accountability/data tracing and for inter agency spacecraft to interoperate with each other, an international CCSDS standard for end-to-end data accountability/tracing needs to be developed. We will first describe the end-to-end accounting service model and functionality that supports the service. This model will describe how science plans that are ultimately transformed into commands can be associated with the telemetry products generated as a result of their execution. Moreover, the interaction between end-to-end accounting and service management will be explored. Finally, we will show how the standard end-to-end accounting service can be applied to a real life flight project i.e., the Mars Reconnaissance Orbiter project.

  5. OISI dynamic end-to-end modeling tool

    Kersten, Michael; Weidler, Alexander; Wilhelm, Rainer; Johann, Ulrich A.; Szerdahelyi, Laszlo

    2000-07-01

    The OISI Dynamic end-to-end modeling tool is tailored to end-to-end modeling and dynamic simulation of Earth- and space-based actively controlled optical instruments such as e.g. optical stellar interferometers. `End-to-end modeling' is meant to denote the feature that the overall model comprises besides optical sub-models also structural, sensor, actuator, controller and disturbance sub-models influencing the optical transmission, so that the system- level instrument performance due to disturbances and active optics can be simulated. This tool has been developed to support performance analysis and prediction as well as control loop design and fine-tuning for OISI, Germany's preparatory program for optical/infrared spaceborne interferometry initiated in 1994 by Dornier Satellitensysteme GmbH in Friedrichshafen.

  6. End Group Modification

    Jahnsen, Rasmus O; Sandberg-Schaal, Anne; Frimodt-Møller, Niels

    2015-01-01

    Increased incidence of infections with multidrug-resistant bacterial strains warrants an intensive search for novel potential antimicrobial agents. Here, an antimicrobial peptide analogue with a cationic/hydrophobic alternating design displaying only moderate activity against Gram-positive pathog......Increased incidence of infections with multidrug-resistant bacterial strains warrants an intensive search for novel potential antimicrobial agents. Here, an antimicrobial peptide analogue with a cationic/hydrophobic alternating design displaying only moderate activity against Gram......, the most favorable hydrophobic activity-inducing moieties were found to be cyclohexylacetyl and pentafluorophenylacetyl groups, while the presence of a short PEG-like chain had no significant effect on activity. Introduction of cationic moieties conferred no effect or merely a moderate activity...

  7. Effect of restricted protein diet supplemented with keto analogues in end-stage renal disease: a systematic review and meta-analysis.

    Jiang, Zheng; Tang, Yi; Yang, Lichuan; Mi, Xuhua; Qin, Wei

    2018-04-01

    To evaluate the efficacy and safety of the restricted protein diet supplemented with keto analogues when applied in end-stage renal disease (ESRD). The Cochrane Library, PubMed, Embase, CBM and CENTRAL databases were searched and reviewed up to January 2017. Clinical trials were analyzed using RevMan 5.3 software. Five randomized controlled trials were selected and included in this study according to our inclusion and exclusion criteria. Changes in serum albumin, PTH, triglyceride, cholesterol, calcium, phosphorus, hemoglobin, Kt/v and CRP before and after treatment were analyzed. Meta-analysis results indicated that, compared with normal protein diet, low-protein diet (LPD) supplemented with keto analogues (sLPD) could improve serum albumin (P diet supplemented with keto analogues (sLPD) may improve nutritional status and prevent hyperparathyroidism in ESRD patients. The current data were mainly obtained from short-term, single-center trails with small sample sizes and limited nutritional status indexes, indicating a need for further study.

  8. A Legal and Ethical Analysis of the Effects of Triggering Conditions on Surrogate Decision-Making in End-of-Life Care in the US.

    Clint Parker, J; Goldberg, Daniel S

    2016-03-01

    The central claim of this paper is that American states' use of so-called "triggering conditions" to regulate surrogate decision-making authority in end-of-life care leaves unresolved a number of important ethical and legal considerations regarding the scope of that authority. The paper frames the issue with a case set in a jurisdiction in which surrogate authority to withdraw life-sustaining treatment is triggered by two specific clinical conditions. The case presents a quandary insofar as the clinical facts do not satisfy the triggering conditions, and yet both the appropriate surrogates and the care team agree that withdrawal of life-sustaining treatment is in the best interest of the patient. The paper surveys applicable law across the 50 states and weighs the arguments for and against the inclusion of such triggering conditions in relevant legal regimes. The paper concludes by assessing the various legal and policy options states have for regulating surrogate decision-making authority in light of the moral considerations (including epistemic difficulties), and notes the possibility for conflict within ethics teams arising from the potential tension between prudence, risk-aversion, and moral obligation.

  9. End-Tidal CO2 Tension Is Predictive of Effective Nocturnal Oxygen Therapy in Patients with Chronic Heart Failure and Central Sleep Apnea.

    Sugimura, Koichiro; Shinozaki, Tsuyoshi; Fukui, Shigefumi; Ogawa, Hiromasa; Shimokawa, Hiroaki

    2016-05-01

    Central sleep apnea (CSA) is characterized by recurring cycles of crescendo-decrescendo ventilation during sleep, and enhances sympathetic nerve activity. Thus CSA has a prognostic impact in patients with chronic heart failure (CHF). Although nocturnal oxygen (O2) therapy decreases frequency of CSA and improves functional exercise capacity, it is also known that some non-responders to the therapy exist. We thus aimed to identify predictors of responders to nocturnal O2 therapy in CHF patients with CSA. In 12 CHF patients with CSA hospitalized at our department, sleep study was performed at 2 consecutive nights. Patients nasally inhaled O2 at either the first or second night in a randomized manner. To predict the percentage reduction in apnea-hypopnea index (%ΔAHI) in response to the nocturnal O2 therapy, we performed multiple regression analysis with a stepwise method with variables including age, brain-natriuretic peptide, circulation time, baseline AHI, hypercapnic ventilatory response and end-tidal carbon dioxide tension (PETCO2). Nocturnal O2 therapy significantly decreased AHI (from 32 ± 13 /h to 12 ± 10 /h, P 50% reduction of AHI), with 88.9% of sensitivity and 66.7% of specificity. In conclusion, PETCO2 is useful to predict the efficacy of O2 therapy in CHF patients with CSA, providing important information to the current nocturnal O2 therapy.

  10. Burn-up Credit Criticality Safety Benchmark-Phase II-E. Impact of Isotopic Inventory Changes due to Control Rod Insertions on Reactivity and the End Effect in PWR UO2 Fuel Assemblies

    Neuber, Jens Christian; Tippl, Wolfgang; Hemptinne, Gwendoline de; Maes, Philippe; Ranta-aho, Anssu; Peneliau, Yannick; Jutier, Ludyvine; Tardy, Marcel; Reiche, Ingo; Kroeger, Helge; Nakata, Tetsuo; Armishaw, Malcom; Miller, Thomas M.

    2015-01-01

    The report describes the final results of the Phase II-E Burn-up Credit Criticality Benchmark conducted by the Expert Group on Burn-up Credit Criticality Safety. The objective of Phase II of the Burn-up Credit Criticality Safety programme is to study the impact of axial burn-up profiles of PWR UO 2 spent fuel assemblies on the reactivity of PWR UO 2 spent fuel assembly configurations. The objective of the Phase II-E benchmark was to study the impact of changes on the spent nuclear fuel isotopic composition due to control rod insertion during depletion on the reactivity and the end effect of spent fuel assemblies with realistic axial burn-up profiles for different control rod insertion depths ranging from 0 cm (no insertion) to full insertion (i.e. to the case that the fuel assemblies were exposed to control rod insertion over their full active length). For this purpose two axial burn-up profiles have been extracted from an AREVA-NP-GmbH-owned 17x17-(24+1) PWR UO 2 spent fuel assembly burn-up profile database. One profile has an average burn-up of 30 MWd/kg U, the other profile is related to an average burn-up of 50 MWd/kg U. Two profiles with different average burn-up values were selected because the shape of the burn-up profile is affected by the average burn-up and the end effect depends on the average burn-up of the fuel. The Phase II-E benchmark exercise complements the Phase II-C and Phase II-D benchmark exercises. In Phase II-D different irradiation histories were analysed using different control rod insertion histories during depletion as well as irradiation histories without control rod insertion. But in all the histories analysed a uniform distribution of the burn-up and hence a uniform distribution of the isotopic composition were assumed; and in all the histories including any usage of control rods full insertion of the control rods was assumed. In Phase II-C the impact of the asymmetry of axial burn-up profiles on the reactivity and the end effect of

  11. Nuclear fuel element end fitting

    Jabsen, F.S.

    1980-01-01

    An invention is described whereby end fittings are formed from lattices of mutually perpendicular plates. At the plate intersections, sockets are secured to the end fittings in a manner that permits the longitudinal axes of each of the sockets to align with the respective lines of intersection of the plates. The sockets all protrude above one of the surfaces of the end fitting. Further, a detent is formed in the proturding sides of each of the sockets. Annular grooves are formed in each of the ends of the fuel rods that are to be mounted between the end fittings. The socket detents protrude into the respective annular grooves, thus engaging the grooves and retaining the fuel rods and end fittings in one integral structure. (auth)

  12. Evaluation of End Mill Coatings

    L. J. Lazarus; R. L. Hester,

    2005-08-01

    Milling tests were run on families of High Speed Steel (HSS) end mills to determine their lives while machining 304 Stainless Steel. The end mills tested were made from M7, M42 and T15-CPM High Speed Steels. The end mills were also evaluated with no coatings as well as with Titanium Nitride (TiN) and Titanium Carbo-Nitride (TiCN) coatings to determine which combination of HSS and coating provided the highest increase in end mill life while increasing the cost of the tool the least. We found end mill made from M42 gave us the largest increase in tool life with the least increase in cost. The results of this study will be used by Cutting Tool Engineering in determining which end mill descriptions will be dropped from our tool catalog.

  13. The Effect of Chang Run Tong on Biomechanical Colon Remodeling in STZ-Induced Type I Diabetic Rats - Is It Related to Advanced Glycation End Product Formation?

    Zhao, Jingbo; Gregersen, Hans

    2015-01-01

    BACKGROUND AND AIM: The Chinese medicine Chang Run Tong (CRT) effectively improved senile constipation in the clinics. The aims of the present study were to investigate the effect of CRT on colonic remodeling in streptozotocin (STZ) induced diabetic rats and to explore the mechanisms of the CRT...

  14. End-to-End Security for Personal Telehealth

    Koster, R.P.; Asim, M.; Petkovic, M.

    2011-01-01

    Personal telehealth is in rapid development with innovative emerging applications like disease management. With personal telehealth people participate in their own care supported by an open distributed system with health services. This poses new end-to-end security and privacy challenges. In this

  15. Directed Self-Assembly in "Breath Figure" Templating of Melamine-Based Amphiphilic Copolymers: Effect of Hydrophilic End-Chain on Honeycomb Film Formation and Wetting.

    Yin, Hongyao; Feng, Yujun; Billon, Laurent

    2018-01-09

    Amphiphilic copolymers are widely used in the fabrication of hierarchically honeycomb-structured films through a "breath figure" (BF) process because the hydrophilic block plays a key role in stabilising water templating. However, the hydrophilic monomers reported are mainly confined to acrylic acid and its derivatives, which largely limits understanding of the formation of BF arrays and the introduction of additional functions on porous films. The relationship between polymer composition, film microstructure and surface properties are also less documented. Herein, a novel melamine-based hydrophilic moiety, N-[3-({3-[(4,6-bis{[3-(dimethylamino)propyl]amino}-1,3,5-triazin-2yl)amino]propyl}(methyl)amino)propyl]methacrylamide (ANME), was incorporated into polystyrene (PS) chains by combining atom-transfer radical polymerisation and post-modification to afford three well-defined end-functionalised PS-PANME derivatives. These polymers were used to fabricate honeycomb films through the BF technique. Both inner and outer microstructures of the films were characterised by optical microscopy, AFM and SEM. Polymer hydrophilicity is enhanced upon increasing the PANME content, which results in variation of the film microstructure and porosity, and provokes a transition from Cassie-Baxter to Wenzel behaviour. Furthermore, the surface wettability of as-prepared honeycomb films and corresponding pillared films is mainly governed by film morphology, rather than by the properties of the polymers. Knowledge of the relationships between polymer composition and film structure, as well as surface wettability, is beneficial to design and prepare hierarchically porous films with desirable structures and properties. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Calculation of absorbed dose and biological effectiveness from photonuclear reactions in a bremsstrahlung beam of end point 50 MeV.

    Gudowska, I; Brahme, A; Andreo, P; Gudowski, W; Kierkegaard, J

    1999-09-01

    The absorbed dose due to photonuclear reactions in soft tissue, lung, breast, adipose tissue and cortical bone has been evaluated for a scanned bremsstrahlung beam of end point 50 MeV from a racetrack accelerator. The Monte Carlo code MCNP4B was used to determine the photon source spectrum from the bremsstrahlung target and to simulate the transport of photons through the treatment head and the patient. Photonuclear particle production in tissue was calculated numerically using the energy distributions of photons derived from the Monte Carlo simulations. The transport of photoneutrons in the patient and the photoneutron absorbed dose to tissue were determined using MCNP4B; the absorbed dose due to charged photonuclear particles was calculated numerically assuming total energy absorption in tissue voxels of 1 cm3. The photonuclear absorbed dose to soft tissue, lung, breast and adipose tissue is about (0.11-0.12)+/-0.05% of the maximum photon dose at a depth of 5.5 cm. The absorbed dose to cortical bone is about 45% larger than that to soft tissue. If the contributions from all photoparticles (n, p, 3He and 4He particles and recoils of the residual nuclei) produced in the soft tissue and the accelerator, and from positron radiation and gammas due to induced radioactivity and excited states of the nuclei, are taken into account the total photonuclear absorbed dose delivered to soft tissue is about 0.15+/-0.08% of the maximum photon dose. It has been estimated that the RBE of the photon beam of 50 MV acceleration potential is approximately 2% higher than that of conventional 60Co radiation.

  17. Calculation of absorbed dose and biological effectiveness from photonuclear reactions in a bremsstrahlung beam of end point 50 MeV

    Gudowska, I.; Brahme, A.; Andreo, P.; Gudowski, W.; Kierkegaard, J.

    1999-01-01

    The absorbed dose due to photonuclear reactions in soft tissue, lung, breast, adipose tissue and cortical bone has been evaluated for a scanned bremsstrahlung beam of end point 50 MeV from a racetrack accelerator. The Monte Carlo code MCNP4B was used to determine the photon source spectrum from the bremsstrahlung target and to simulate the transport of photons through the treatment head and the patient. Photonuclear particle production in tissue was calculated numerically using the energy distributions of photons derived from the Monte Carlo simulations. The transport of photoneutrons in the patient and the photoneutron absorbed dose to tissue were determined using MCNP4B; the absorbed dose due to charged photonuclear particles was calculated numerically assuming total energy absorption in tissue voxels of 1 cm 3 . The photonuclear absorbed dose to soft tissue, lung, breast and adipose tissue is about (0.11-0.12)±0.05% of the maximum photon dose at a depth of 5.5 cm. The absorbed dose to cortical bone is about 45% larger than that to soft tissue. If the contributions from all photoparticles (n, p, 3 He and 4 He particles and recoils of the residual nuclei) produced in the soft tissue and the accelerator, and from positron radiation and gammas due to induced radioactivity and excited states of the nuclei, are taken into account the total photonuclear absorbed dose delivered to soft tissue is about 0.15±0.08% of the maximum photon dose. It has been estimated that the RBE of the photon beam of 50 MV acceleration potential is approximately 2% higher than that of conventional 60 Co radiation. (author)

  18. Effects of germination on the activities of amylases and phenolic enzymes in sorghum varieties grouped according to food end-use properties

    Dicko, M.H.; Gruppen, H.; Zouzouho, O.C.; Traore, A.S.; Berkel, van W.J.H.; Voragen, A.G.J.

    2006-01-01

    Fifty sorghum varieties were screened to determine the effects of germination on levels of starch, -amylase, -amylase, phenylalanine ammonia lyase (PAL), peroxidase (POX) and polyphenol oxidase (PPO). Germination decreased starch content, with amylose being more degraded than amylopectin. In

  19. [An end to poverty

    Engelhard, P

    1994-10-01

    The African continent is distinguished by a much higher fertility rate than other regions. Fertility in Africa has remained almost constant at slightly over six children per woman on average, while important declines have occurred elsewhere over the past 25 years. High fertility in Africa is often attributed to poor diffusion of family planning, early marriage, and low female educational attainment, but other cultural and economic factors are involved. The significant decline of infant mortality over the past several decades has produced growth rates never before observed. Africa's very young populations may be at the origin of uncontrollable political disorder, as young persons with bleak prospects fall easy prey to ethnic, religious, and political extremism. Demographic growth has become an additional barrier to development. High fertility is tolerated or encouraged as constituting a cultural trait, but the resulting population growth is not a cultural trait. Demographic pressure has increased environmental problems in many regions. It is estimated that over ten million rural residents of the Sahel have been affected by soil degradation. The per capita availability of arable land fell from one-half to one-third hectare between 1965 and 1987. Shortages of firewood and water have become more common. The relationship between demographic growth, environmental crisis, and poverty in the countryside depends on other factors such as production techniques, modes of access to land and water, and the degree of security of land tenure. Population pressure was not the initial factor that disturbed the balance of the traditional societies, but it exacerbated the effects of other forces such as the introduction of cash crops and monetarization of the economy. Rural exodus and accelerated urban migration have been prompted in large part by the higher incomes and greater availability of services of all types in the cities. Achieving control of fertility in Africa will require

  20. Respiratory effects of low versus high tidal volume with or without positive end-expiratory pressure in anesthetized dogs with healthy lungs.

    De Monte, Valentina; Bufalari, Antonello; Grasso, Salvatore; Ferrulli, Fabienne; Crovace, Alberto Maria; Lacitignola, Luca; Staffieri, Francesco

    2018-05-01

    OBJECTIVE To evaluate the impact of 2 tidal volumes (T V s) with or without positive end-expiratory pressure (PEEP) on lung mechanics, aeration, and gas exchange in healthy anesthetized dogs. ANIMALS 40 mixed-breed dogs with healthy lungs. PROCEDURES Anesthetized dogs were randomly assigned to 4 groups (n = 10/group) with different ventilatory settings: T V of 8 mL/kg and PEEP of 0 cm H 2 O (low T V group), T V of 8 mL/kg and PEEP of 5 cm H 2 O (low T V plus PEEP group), T V of 15 mL/kg and PEEP of 0 cm H 2 O (high T V group), or T V of 15 mL/kg and PEEP of 5 cm H 2 O (high T V plus PEEP group). Expired CO 2 and respiratory rate were titrated on the basis of a predetermined stepwise protocol. Gas exchange, respiratory mechanics, and pulmonary aeration were evaluated by means of CT 30 minutes after starting mechanical ventilation at the assigned setting. RESULTS Partial pressures of arterial and expired CO 2 were higher in the low T V and low T V plus PEEP groups than in the high T V and high T V plus PEEP groups. Peak and plateau airway pressures were higher in the PEEP group than in the other groups. Static lung compliance was higher in the high T V plus PEEP group than in the low T V group. Relative percentages of atelectatic and poorly aerated lung were lower in the high T V plus PEEP group than in the other groups. Oxygenation was similar among groups. CONCLUSIONS AND CLINICAL RELEVANCE Differences in T V and PEEP application during mechanical ventilation may affect respiratory function in anesthetized dogs with healthy lungs. Ventilation with a T V of 15 mL/kg and PEEP of 5 cm H 2 O significantly improved lung compliance and reduced the amount of atelectatic and poorly aerated lung.

  1. ATLAS end-cap detector

    Maximilien Brice

    2003-01-01

    Three scientists from the Institute of Nuclear Phyiscs at Novossibirsk with one of the end-caps of the ATLAS detector. The end-caps will be used to detect particles produced in the proton-proton collisions at the heart of the ATLAS experiment that are travelling close to the axis of the two beams.

  2. Flexible End2End Workflow Automation of Hit-Discovery Research.

    Holzmüller-Laue, Silke; Göde, Bernd; Thurow, Kerstin

    2014-08-01

    The article considers a new approach of more complex laboratory automation at the workflow layer. The authors purpose the automation of end2end workflows. The combination of all relevant subprocesses-whether automated or manually performed, independently, and in which organizational unit-results in end2end processes that include all result dependencies. The end2end approach focuses on not only the classical experiments in synthesis or screening, but also on auxiliary processes such as the production and storage of chemicals, cell culturing, and maintenance as well as preparatory activities and analyses of experiments. Furthermore, the connection of control flow and data flow in the same process model leads to reducing of effort of the data transfer between the involved systems, including the necessary data transformations. This end2end laboratory automation can be realized effectively with the modern methods of business process management (BPM). This approach is based on a new standardization of the process-modeling notation Business Process Model and Notation 2.0. In drug discovery, several scientific disciplines act together with manifold modern methods, technologies, and a wide range of automated instruments for the discovery and design of target-based drugs. The article discusses the novel BPM-based automation concept with an implemented example of a high-throughput screening of previously synthesized compound libraries. © 2014 Society for Laboratory Automation and Screening.

  3. End-to-End Delay Model for Train Messaging over Public Land Mobile Networks

    Franco Mazzenga

    2017-11-01

    Full Text Available Modern train control systems rely on a dedicated radio network for train to ground communications. A number of possible alternatives have been analysed to adopt the European Rail Traffic Management System/European Train Control System (ERTMS/ETCS control system on local/regional lines to improve transport capacity. Among them, a communication system based on public networks (cellular&satellite provides an interesting, effective and alternative solution to proprietary and expensive radio networks. To analyse performance of this solution, it is necessary to model the end-to-end delay and message loss to fully characterize the message transfer process from train to ground and vice versa. Starting from the results of a railway test campaign over a 300 km railway line for a cumulative 12,000 traveled km in 21 days, in this paper, we derive a statistical model for the end-to-end delay required for delivering messages. In particular, we propose a two states model allowing for reproducing the main behavioral characteristics of the end-to-end delay as observed experimentally. Model formulation has been derived after deep analysis of the recorded experimental data. When it is applied to model a realistic scenario, it allows for explicitly accounting for radio coverage characteristics, the received power level, the handover points along the line and for the serving radio technology. As an example, the proposed model is used to generate the end-to-end delay profile in a realistic scenario.

  4. Begin with the End in Mind: Measuring the Effectiveness of Remediation on Student Performance on the Test of Essential Academic Skills (TEAS-V)

    Cumberbatch-Sullivan, Karen J.

    2013-01-01

    This quantitative, causal-comparative research study investigated the effectiveness of a strategy to address concerns in nursing education about the high attrition rates and poor retention rates of pre-licensure nursing students, particularly in the first semester of nursing school. Two research questions guided this study and focused on the…

  5. Alkaline peroxide treatment of ECF bleached softwood kraft pulps: part 2. effect of increased fiber charge on refining, wet-end application, and hornification

    Zheng Dang; Thomas Elder; Jeffery S. Hsieh; Arthur J. Ragauskas

    2007-01-01

    The effect of increased fiber charge on refining, cationic starch adsorption, and hornification was examined. Two pulps were investigated: (1) a softwood (SW) kraft pulp (KP) which was bleached elementally chlorine-free (ECF) and sewed as control; and (2) a control pulp treated with alkaline peroxide, which had a higher fiber charge. It was shown that increased fiber...

  6. Photoperiodic control of floral initiation in rice plant, 4: Promotive effect of far-red radiation given at the end of day

    Ikeda, K. [Mie Univ., Tsu (Japan)

    1987-12-15

    Using a strongly photoperiod-sensitive cultivar of rice, Oryza sativa L., ev. Norin 18, though several cultivars with weak sensitivity to photoperiod were added in some trials, we have investigated on the effect of FR radiation at the close of the daily photoperiod on the flowering response.

  7. Effects of two feedback interventions on end-of-life outcomes in nursing home residents with dementia: A cluster-randomized controlled three-armed trial

    Boogaard, J.A.; Vet, H.C.W. de; Soest-Poortvliet, M.C. van; Anema, J.R.; Achterberg, W.P.; Steen, J.T. van der

    2018-01-01

    BACKGROUND: Despite increased attention for palliative care in dementia, recent studies found burdensome symptoms and unmet family caregiver needs in the last phase of life. Feedback is being used to improve the quality of palliative care, but we do not know how effective it is. AIM: To assess the

  8. Increasing Active Student Responding in a University Applied Behavior Analysis Course: The Effect of Daily Assessment and Response Cards on End of Week Quiz Scores

    Malanga, Paul R.; Sweeney, William J.

    2008-01-01

    The study compared the effects of daily assessment and response cards on average weekly quiz scores in an introduction to applied behavior analysis course. An alternating treatments design (Kazdin 1982, "Single-case research designs." New York: Oxford University Press; Cooper et al. 2007, "Applied behavior analysis." Upper Saddle River:…

  9. "THE EVALUATION OF THE POSSIBLE EFFECT OF POSITIVE END EXPIRATORY PRESSURE (PEEP) ON PHARMACOKINETICS OF PHENYTOIN IN PATIENTS WITH ACUTE BRAIN INJURY UNDER MECHANICAL VENTILATION."

    "Elham Hadidi; Mojtaba Mojtahedzadeh; Mohammad Reza Rouini; Behzad Eftekhar; Mohammad Abdollahi; Atabak Najafi; Mohammad R. Khajavi; Saeed Rezaee; Reza Ghaffari; Minoo Afshar"

    2005-01-01

    Positive ventilation has shown to have an influence on pharmacokinetic and disposition of some drugs.Beacause phenytoin with a narrow therapautic range, is the most commonly used drug for prophylaxis and treatment of early seizures after acute brain injuries, in the present study the effect of short term PEEP (5-10 cm H2O for at least 8 hours) on phenytoin serum concentration and pharmacokinetic parameters such as Vmax and clearance in brain injured patients under mechanical ventilation was e...

  10. Effect of preload reduction by hemodialysis on left atrial volume and echocardiographic Doppler parameters in patients with end-stage renal disease.

    Barberato, Silvio H; Mantilla, Diego E V; Misocami, M Arcio; Gonçalves, Simone M; Bignelli, Alexandre T; Riella, Miguel C; Pecoits-Filho, Roberto

    2004-11-01

    Left atrial (LA) volume has been proposed as a less preload-dependent parameter of diastolic function than Doppler mitral inflow. We hypothesize that in the absence of mitral regurgitation and atrial fibrilation, LA enlargement could be a more practical (and relatively preload-independent) method for the evaluation of left ventricular diastolic function. The aim of the present study was to determine the effects of preload reduction by hemodialysis on LA volume.

  11. Structural stability of naphthyl end-capped oligothiophenes in organic field-effect transistors measured by grazing-incidence X-ray diffraction in operando

    Huss-Hansen, Mathias K.; Lauritzen, Andreas E.; Bikondoa, Oier

    2017-01-01

    We report on microstructural durability of 5,5′-bis(naphth-2-yl)-2,2′-bithiophene (NaT2) in organic field-effect transistors (OFETs) in operando monitored by grazing-incidence X-ray diffraction (GIXRD). NaT2 maintains its monoclinic bulk motif in operating OFETs with a=20.31±0.06 Å, b=6.00±0.01 Å...

  12. Utilizing Domain Knowledge in End-to-End Audio Processing

    Tax, Tycho; Antich, Jose Luis Diez; Purwins, Hendrik

    2017-01-01

    to learn the commonly-used log-scaled mel-spectrogram transformation. Secondly, we demonstrate that upon initializing the first layers of an end-to-end CNN classifier with the learned transformation, convergence and performance on the ESC-50 environmental sound classification dataset are similar to a CNN......-based model trained on the highly pre-processed log-scaled mel-spectrogram features....

  13. End-to-end tests using alanine dosimetry in scanned proton beams

    Carlino, A.; Gouldstone, C.; Kragl, G.; Traneus, E.; Marrale, M.; Vatnitsky, S.; Stock, M.; Palmans, H.

    2018-03-01

    This paper describes end-to-end test procedures as the last fundamental step of medical commissioning before starting clinical operation of the MedAustron synchrotron-based pencil beam scanning (PBS) therapy facility with protons. One in-house homogeneous phantom and two anthropomorphic heterogeneous (head and pelvis) phantoms were used for end-to-end tests at MedAustron. The phantoms were equipped with alanine detectors, radiochromic films and ionization chambers. The correction for the ‘quenching’ effect of alanine pellets was implemented in the Monte Carlo platform of the evaluation version of RayStation TPS. During the end-to-end tests, the phantoms were transferred through the workflow like real patients to simulate the entire clinical workflow: immobilization, imaging, treatment planning and dose delivery. Different clinical scenarios of increasing complexity were simulated: delivery of a single beam, two oblique beams without and with range shifter. In addition to the dose comparison in the plastic phantoms the dose obtained from alanine pellet readings was compared with the dose determined with the Farmer ionization chamber in water. A consistent systematic deviation of about 2% was found between alanine dosimetry and the ionization chamber dosimetry in water and plastic materials. Acceptable agreement of planned and delivered doses was observed together with consistent and reproducible results of the end-to-end testing performed with different dosimetric techniques (alanine detectors, ionization chambers and EBT3 radiochromic films). The results confirmed the adequate implementation and integration of the new PBS technology at MedAustron. This work demonstrates that alanine pellets are suitable detectors for end-to-end tests in proton beam therapy and the developed procedures with customized anthropomorphic phantoms can be used to support implementation of PBS technology in clinical practice.

  14. Wear of micro end mills

    Bissacco, Giuliano; Hansen, Hans Nørgaard; De Chiffre, Leonardo

    2005-01-01

    This paper addresses the important issue of wear on micro end mills considering relevant metrological tools for its characterization and quantification. Investigation of wear on micro end mills is particularly difficult and no data are available in the literature. Small worn volumes cause large...... part. For this investigation 200 microns end mills are considered. Visual inspection of the micro tools requires high magnification and depth of focus. 3D reconstruction based on scanning electron microscope (SEM) images and stereo-pair technique is foreseen as a possible method for quantification...

  15. Calorimetry end-point predictions

    Fox, M.A.

    1981-01-01

    This paper describes a portion of the work presently in progress at Rocky Flats in the field of calorimetry. In particular, calorimetry end-point predictions are outlined. The problems associated with end-point predictions and the progress made in overcoming these obstacles are discussed. The two major problems, noise and an accurate description of the heat function, are dealt with to obtain the most accurate results. Data are taken from an actual calorimeter and are processed by means of three different noise reduction techniques. The processed data are then utilized by one to four algorithms, depending on the accuracy desired to determined the end-point

  16. Numerical simulations for effects of pressure and temperature on counter-current flow limitation at lower end of a vertical pipe

    Kusunoki, Takayoshi; Tomiyama, Akio; Murase, Michio; Takata, Takashi

    2015-01-01

    The purpose of this study is to derive a CCFL (counter-current flow limitation) correlation and its uncertainty for steam generator (SG) U-tubes in a pressurized water reactor. Pressure and temperature are very high in actual U-tubes. Hence, in this paper, we evaluated effects of pressure and temperature on CCFL characteristics using numerical simulations. Results computed with the k-ω SST turbulence model gave a trend opposite to the ROSA-IV/LSTF data in the pressure range of 1.0-7.0 MPa, and the computed falling water flow rates decreased as pressure increased. Because computations with the k-ω SST were unstable at lower pressures than 1.0 MPa, the laminar flow model was used even though it significantly overestimated falling water flow rates. The results showed that: (1) the flooding under steam-water conditions was mitigated more than that under air-water conditions; (2) the falling water flow rate had a maximum value at about 1.0 MPa; and (3) the laminar flow model resulted in an opposite trend to the ROSA-IV/LSTF data in the pressure range of 1.0-7.0 MPa, as the k-ω SST turbulence model did. Thus, we concluded that accurate measurements should be made in a wide range of pressures using a single vertical pipe in order to confirm effects of fluid properties on CCFL. (author)

  17. Effect of intravenous omega-3 fatty acid infusion and hemodialysis on fatty acid composition of free fatty acids and phospholipids in patients with end-stage renal disease.

    Madsen, Trine; Christensen, Jeppe Hagstrup; Toft, Egon; Aardestrup, Inge; Lundbye-Christensen, Søren; Schmidt, Erik B

    2011-01-01

    Patients treated with hemodialysis (HD) have been reported to have decreased levels of ω-3 polyunsaturated fatty acids (PUFAs) in plasma and cells. The aim of this study was to investigate the effect of ω-3 PUFAs administered intravenously during HD, as well as the effect of HD treatment, on the fatty acid composition of plasma free fatty acids (FFAs), plasma phospholipids, and platelet phospholipids. Forty-four HD patients were randomized to groups receiving either a single dose of a lipid emulsion containing 4.1 g of ω-3 PUFAs or placebo (saline) administered intravenously during HD. Blood was drawn immediately before (baseline) and after (4 hours) HD and before the next HD session (48 hours). Fatty acid composition was measured using gas chromatography. The increase in ω-3 FFAs was greater in the ω-3 PUFA group compared with the placebo group, whereas the increase in total FFAs was similar between the 2 groups. In the ω-3 PUFA group, ω-3 PUFAs in plasma phospholipids were higher after 48 hours than at baseline, and in platelet phospholipids, ω-3 PUFAs increased after 4 hours. In the placebo group, no changes were observed in ω-3 PUFAs in plasma and platelet phospholipids. Intravenous ω-3 PUFAs administered during HD caused a transient selective increase in ω-3 FFA concentration. Furthermore, ω-3 PUFAs were rapidly incorporated into platelets, and the content of ω-3 PUFAs in plasma phospholipids increased after 48 hours.

  18. Measurements and analysis of end-to-end Internet dynamics

    Paxson, Vern [Univ. of California, Berkeley, CA (United States). Computer Science Division

    1997-04-01

    Accurately characterizing end-to-end Internet dynamics - the performance that a user actually obtains from the lengthy series of network links that comprise a path through the Internet - is exceptionally difficult, due to the network`s immense heterogeneity. At the heart of this work is a `measurement framework` in which a number of sites around the Internet host a specialized measurement service. By coordinating `probes` between pairs of these sites one can measure end-to-end behavior along O(N2) paths for a framework consisting of N sites. Consequently, one obtains a superlinear scaling that allows measuring a rich cross-section of Internet behavior without requiring huge numbers of observation points. 37 sites participated in this study, allowing the author to measure more than 1,000 distinct Internet paths. The first part of this work looks at the behavior of end-to-end routing: the series of routers over which a connection`s packets travel. Based on 40,000 measurements made using this framework, the author analyzes: routing `pathologies` such as loops, outages, and flutter; the stability of routes over time; and the symmetry of routing along the two directions of an end-to-end path. The author finds that pathologies increased significantly over the course of 1995 and that Internet paths are heavily dominated by a single route. The second part of this work studies end-to-end Internet packet dynamics. The author analyzes 20,000 TCP transfers of 100 Kbyte each to investigate the performance of both the TCP endpoints and the Internet paths. The measurements used for this part of the study are much richer than those for the first part, but require a great degree of attention to issues of calibration, which are addressed by applying self-consistency checks to the measurements whenever possible. The author finds that packet filters are capable of a wide range of measurement errors, some of which, if undetected, can significantly taint subsequent analysis.

  19. Effects of mid-term student evaluations of teaching as measured by end-of-term evaluations: An emperical study of course evaluations

    Clemmensen, Line Katrine Harder; Sliusarenko, Tamara; Ersbøll, Bjarne Kjær

    2013-01-01

    Universities have varying policies on how and when to perform student evaluations of courses and teachers. More empirical evidence of the consequences of such policies on quality enhancement of teaching and learning is needed. A study (35 courses at the Technical University of Denmark....... The evaluations generally showed positive improvements over the semester for courses with access, and negative improvements for those without access. Improvements related to: Student learning, student satisfaction, teaching activities, and communication showed statistically significant average differences of 0.......1-0.2 points between the two groups. These differences are relatively large compared to the standard deviation of the scores when student effect is removed (approximately 0.7). We conclude that university policies on course evaluations seem to have an impact on the development of the teaching and learning...

  20. Fuel cell end plate structure

    Guthrie, Robin J.; Katz, Murray; Schroll, Craig R.

    1991-04-23

    The end plates (16) of a fuel cell stack (12) are formed of a thin membrane. Pressure plates (20) exert compressive load through insulation layers (22, 26) to the membrane. Electrical contact between the end plates (16) and electrodes (50, 58) is maintained without deleterious making and breaking of electrical contacts during thermal transients. The thin end plate (16) under compressive load will not distort with a temperature difference across its thickness. Pressure plate (20) experiences a low thermal transient because it is insulated from the cell. The impact on the end plate of any slight deflection created in the pressure plate by temperature difference is minimized by the resilient pressure pad, in the form of insulation, therebetween.

  1. End of Life: Suicide Grief

    Healthy Lifestyle End of life A loved one's suicide can be emotionally devastating. Use healthy coping strategies — ... Clinic Staff When a loved one dies by suicide, overwhelming emotions can leave you reeling. Your grief ...

  2. End-stage kidney disease

    ... stage; Kidney failure - end stage; ESRD; ESKD Images Kidney anatomy References Fogarty DG, Taal MW. A stepped care approach to the management of chronic kidney disease. In: Skorecki K, Chertow GM, Marsden PA, ...

  3. High-End Scientific Computing

    EPA uses high-end scientific computing, geospatial services and remote sensing/imagery analysis to support EPA's mission. The Center for Environmental Computing (CEC) assists the Agency's program offices and regions to meet staff needs in these areas.

  4. Nuclear instrumentation cable end seal

    Cannon, C.P.; Brown, D.P.

    1979-01-01

    An improved coaxial end seal for hermetically sealed nuclear instrumentation cable exhibiting an improved breakdown pulse noise characteristic under high voltage, high temperature conditions is described. A tubular insulator body has metallized interior and exterior surface portions which are braze sealed to a center conductor and an outer conductive sheath. The end surface of the insulator body which is directed toward the coaxial cable to which it is sealed has a recessed surface portion within which the braze seal material terminates

  5. Response Surface Methodology Approach on Effect of Cutting Parameter on Tool Wear during End Milling of High Thermal Conductivity Steel -150 (HTCS-150)

    Mohd Hadzley, A B; Wan Mohd Azahar, W M Y; Izamshah, R; Mohd Shahir, K; Mohd Amran, A; Anis Afuza, A

    2016-01-01

    This paper presents a study of development the tool life's mathematical model during the milling process on High Thermal Conductivity Steel 150 (HTCS-150) 56 HRC. Using response surface methodology, the mathematical models for tool life have been developed in terms of cutting speed, feed rate and depth of cut. Box-Behnken techniques is a part of Response Surface Methodology (RSM) has been used to carry out the work plan to predict, the tool wear and generate the numerical equation in relation to independent variable parameters by Design Expert software. Dry milling experiments were conducted by using two levels of cutting speed, feed rate and depth of cut. In this study, the variable for the cutting speed, feed rate and depth of cut were in the range of 484-553 m/min, 0.31-0.36 mm/tooth, and 0.1-0.5 mm, width of cut is constantly 0.01mm per passes. The tool wear was measured using tool maker microscope. The effect of input factors that on the responds were identified by using mean of ANOVA. The responds of tool wear then simultaneously optimized. The validation of the test reveals the model accuracy 5% and low tool wear under same experimental condition. (paper)

  6. Effect of different forms of nitrogen fertlizers applied in the end of tillering on yield and quality of winter wheat grain

    Ladislav Ducsay

    2005-01-01

    Full Text Available In the years 1999 to 2001 in conditions of small-plot field experiments was carried out on loamy degraded chernozems at the Plant Breeding Station of Sládkovičovo-Nový Dvor to solve the problems of topdressing winter wheat (Triticum aestivum, L., variety Astella, with different forms of nitrogenous fertilizers. Nitrogenous fertilizers were applied at the growth phase of the 6th leaf (Zadoks = 29. Four various forms of fertilizers were exemined: urea solution, DAM-390, DAM-390 + Dumag, DASA. Different weather conditions statistically highly significantly influenced grain yield in respective experimental years. Topdressing with nitrogen (30 kg N.ha–1 caused statistically highly significant increase of grain yield in all fertilized variants ranging from +0.29 t.ha–1 (applied of DAM-390 to +0.69 t.ha–1 (applied of DASA according to respective treatments. Average grain yield in unfertilized control variant represented 7.23 t.ha–1. Nitrogen nutrition showed positive effect on the main macroelements offtake (N, P, K, Ca, Mg, S by winter wheat grain in all fertilized variants. Nitrogen fertilizing positively influenced formation of wet gluten and crude protein with highest increment in variant with DASA and variant with DAM-390 + Dumag.

  7. Response Surface Methodology Approach on Effect of Cutting Parameter on Tool Wear during End Milling of High Thermal Conductivity Steel -150 (HTCS-150)

    Mohd Hadzley, A. B.; Mohd Azahar, W. M. Y. Wan; Izamshah, R.; Mohd Shahir, K.; Mohd Amran, A.; Anis Afuza, A.

    2016-02-01

    This paper presents a study of development the tool life's mathematical model during the milling process on High Thermal Conductivity Steel 150 (HTCS-150) 56 HRC. Using response surface methodology, the mathematical models for tool life have been developed in terms of cutting speed, feed rate and depth of cut. Box-Behnken techniques is a part of Response Surface Methodology (RSM) has been used to carry out the work plan to predict, the tool wear and generate the numerical equation in relation to independent variable parameters by Design Expert software. Dry milling experiments were conducted by using two levels of cutting speed, feed rate and depth of cut. In this study, the variable for the cutting speed, feed rate and depth of cut were in the range of 484-553 m/min, 0.31-0.36 mm/tooth, and 0.1-0.5 mm, width of cut is constantly 0.01mm per passes. The tool wear was measured using tool maker microscope. The effect of input factors that on the responds were identified by using mean of ANOVA. The responds of tool wear then simultaneously optimized. The validation of the test reveals the model accuracy 5% and low tool wear under same experimental condition.

  8. [End-of-life care and end-of-life medical decisions: the ITAELD study].

    Miccinesi, Guido; Puliti, Donella; Paci, Eugenio

    2011-01-01

    To describe the attitudes towards end of life care and the practice of end-of-life medical decisions with possible life-shortening effect among Italian physicians. Cross sectional study (last death among the assisted patients in the last 12 months was considered). In the year 2007, 5,710 GPs and 8,950 hospital physicians were invited all over Italy to participate in the ITAELDstudy through anonymous mail questionnaire. Proportion of agreement with statements on end-of-life care issues. Proportion of deaths with an end-of-life medical decision. The response rate was 19.2%. The 65% of respondents agreed with the duty to respect any non-treatment request of the competent patient, the 55% agreed with the same duty in case of advanced directives, the 39% in case of proxy's request. The 53% of respondents agreed with the ethical acceptability of active euthanasia in selected cases. Among 1,850 deaths the 57.7% did not receive any end-of-life medical decision. For a further 21.0% no decision was possible, being sudden and unexpected deaths. In the remaining 21.3% at least one end-of-life medical decision was reported: 0.8% was classified as physician assisted death, 20.5% as non-treatment decision. Among all deceased the 19.6% were reported to have been deeply sedated. Being favourable to the use of opioids in terminal patients was associated to non-treatment decisions with possible but non-intentional life shortening effect; agreeing with the duty to fully respect any actual non-treatment request of the competent patient was associated to end-of life medical decisions with intentional life-shortening effect (adjusted OR>10 in both cases). The life stance and ethical beliefs of physicians determine their behaviour at the end of life wherever specific statements of law are lacking. Therefore education and debate are needed on these issues.

  9. "THE EVALUATION OF THE POSSIBLE EFFECT OF POSITIVE END EXPIRATORY PRESSURE (PEEP ON PHARMACOKINETICS OF PHENYTOIN IN PATIENTS WITH ACUTE BRAIN INJURY UNDER MECHANICAL VENTILATION."

    "Elham Hadidi

    2005-04-01

    Full Text Available Positive ventilation has shown to have an influence on pharmacokinetic and disposition of some drugs.Beacause phenytoin with a narrow therapautic range, is the most commonly used drug for prophylaxis and treatment of early seizures after acute brain injuries, in the present study the effect of short term PEEP (5-10 cm H2O for at least 8 hours on phenytoin serum concentration and pharmacokinetic parameters such as Vmax and clearance in brain injured patients under mechanical ventilation was examined. Ten patients with moderate to severe acute brain injury who were placed on mechanical ventilation with an initial PEEP level of 0-5 cm H2O were included in the study. Patients received phenytoin loading dose of 15 mg/kg followed by a maintenance daily dose of 3-7 mg/kg initiated within 12 hours of loading dose. Sampels were taken on two different occasions before and after PEEP elevation. Total phenytoin serum concentrations were determined by HPLC method. A time invarient Michaelis-Menten pharmacokinetic model was used to calculate Vmax and clearance for each patient.Derrived variables were calculated as follows: Vmax, 3.5-6.8 and 3.7-8.2 mg/kg/day; Clearance, 0.1-0.7 and 0.1-1.2 l/kg/day (before and after PEEP elevation, respectively. Our data have shown a wide range of variability (2.6-32.5 mg/l in phenytoin serum concentrations. There were no statistically significant differences in the measured total concentrations (p=0.721 and calculated Vmax and clearance (p=0.285before and after PEEP elevation. Administration of fluid and inotropic agents, limitation in application of higher levels of PEEP and drug interactions, shall be considered as possible explanations for these findings.

  10. Octanol reduces end-plate channel lifetime

    Gage, Peter W.; McBurney, Robert N.; Van Helden, Dirk

    1978-01-01

    1. Post-synaptic effects of n-octanol at concentrations of 0·1-1 mM were examined in toad sartorius muscles by use of extracellular and voltage-clamp techniques. 2. Octanol depressed the amplitude and duration of miniature end-plate currents and hence depressed neuromuscular transmission. 3. The decay of miniature end-plate currents remained exponential in octanol solutions even when the time constant of decay (τD) was decreased by 80-90%. 4. The lifetime of end-plate channels, obtained by analysis of acetylcholine noise, was also decreased by octanol. The average lifetime measured from noise spectra agreed reasonably well with the time constant of decay of miniature end-plate currents, both in control solution and in octanol solutions. 5. Octanol caused a reduction in the conductance of end-plate channels. Single channel conductance was on average about 25 pS in control solution and 20 pS in octanol. 6. In most cells the normal voltage sensitivity of the decay of miniature end-plate currents was retained in octanol solutions. The lifetime of end-plate channels measured from acetylcholine noise also remained voltage-sensitive in octanol solutions. In some experiments in which channel lifetime was exceptionally reduced the voltage sensitivity was less than normal. 7. In octanol solutions, τD was still very sensitive to temperature changes in most cells although in some the temperature sensitivity of τD was clearly reduced. Changes in τD with temperature could generally be fitted by the Arrhenius equation suggesting that a single step reaction controlled the decay of currents both in control and in octanol solutions. In some cells in which τD became less than 0·3 ms, the relationship between τD and temperature became inconsistent with the Arrhenius equation. 8. As the decay of end-plate currents in octanol solutions remains exponential, and the voltage and temperature sensitivity can be unchanged even when τD is significantly reduced, it seems likely that

  11. Effects of distance from center of a weld to fixed end on residual stress and stress intensity factor of a piping weld. Evaluation of SCC growth under residual stress field. Report 1

    Miyazaki, Katsumasa; Numata, Masanori; Saito, Koichi; Mochizuki, Masahito

    2006-01-01

    The fixed conditions of butt welds between straight pipe and valve or pump in the actual piping system are different from those of straight pipes. However, the effect of fixed condition on the residual stress and the stress intensity factor for evaluation of structural integrity of cracked piping was not clear. In this study, the finite element analyses were conducted by considering the differences in the distance from the center of weld to the fixed end L to clarify the effect of fixed condition on the residual stress and the stress intensity factor. For the 600 A piping, the axial residual stress distribution was not affected by the distance L. Furthermore, the stress intensity factor of circumferential crack under the residual stress field with fixed condition could be estimated by using the existing simplified solution for piping. (author)

  12. System of end-to-end symmetric database encryption

    Galushka, V. V.; Aydinyan, A. R.; Tsvetkova, O. L.; Fathi, V. A.; Fathi, D. V.

    2018-05-01

    The article is devoted to the actual problem of protecting databases from information leakage, which is performed while bypassing access control mechanisms. To solve this problem, it is proposed to use end-to-end data encryption, implemented at the end nodes of an interaction of the information system components using one of the symmetric cryptographic algorithms. For this purpose, a key management method designed for use in a multi-user system based on the distributed key representation model, part of which is stored in the database, and the other part is obtained by converting the user's password, has been developed and described. In this case, the key is calculated immediately before the cryptographic transformations and is not stored in the memory after the completion of these transformations. Algorithms for registering and authorizing a user, as well as changing his password, have been described, and the methods for calculating parts of a key when performing these operations have been provided.

  13. EGb761 provides a protective effect against Aβ1-42 oligomer-induced cell damage and blood-brain barrier disruption in an in vitro bEnd.3 endothelial model.

    Wen-bin Wan

    Full Text Available Alzheimer's disease (AD is the most common form of senile dementia which is characterized by abnormal amyloid beta (Aβ accumulation and deposition in brain parenchyma and cerebral capillaries, and leads to blood-brain barrier (BBB disruption. Despite great progress in understanding the etiology of AD, the underlying pathogenic mechanism of BBB damage is still unclear, and no effective treatment has been devised. The standard Ginkgo biloba extract EGb761 has been widely used as a potential cognitive enhancer for the treatment of AD. However, the cellular mechanism underlying the effect remain to be clarified. In this study, we employed an immortalized endothelial cell line (bEnd.3 and incubation of Aβ(1-42 oligomer, to mimic a monolayer BBB model under conditions found in the AD brain. We investigated the effect of EGb761 on BBB and found that Aβ1-42 oligomer-induced cell injury, apoptosis, and generation of intracellular reactive oxygen species (ROS, were attenuated by treatment with EGb761. Moreover, treatment of the cells with EGb761 decreased BBB permeability and increased tight junction scaffold protein levels including ZO-1, Claudin-5 and Occludin. We also found that the Aβ(1-42 oligomer-induced upregulation of the receptor for advanced glycation end-products (RAGE, which mediates Aβ cytotoxicity and plays an essential role in AD progression, was significantly decreased by treatment with EGb761. To our knowledge, we provide the first direct in vitro evidence of an effect of EGb761 on the brain endothelium exposed to Aβ(1-42 oligomer, and on the expression of tight junction (TJ scaffold proteins and RAGE. Our results provide a new insight into a possible mechanism of action of EGb761. This study provides a rational basis for the therapeutic application of EGb761 in the treatment of AD.

  14. The end of cheap uranium

    Dittmar, Michael

    2013-01-01

    Historic data from many countries demonstrate that on average no more than 50–70% of the uranium in a deposit could be mined. An analysis of more recent data from Canada and Australia leads to a mining model with an average deposit extraction lifetime of 10 ± 2 years. This simple model provides an accurate description of the extractable amount of uranium for the recent mining operations. Using this model for all larger existing and planned uranium mines up to 2030, a global uranium mining peak of at most 58 ± 4 ktons around the year 2015 is obtained. Thereafter we predict that uranium mine production will decline to at most 54 ± 5 ktons by 2025 and, with the decline steepening, to at most 41 ± 5 ktons around 2030. This amount will not be sufficient to fuel the existing and planned nuclear power plants during the next 10–20 years. In fact, we find that it will be difficult to avoid supply shortages even under a slow 1%/year worldwide nuclear energy phase-out scenario up to 2025. We thus suggest that a worldwide nuclear energy phase-out is in order. If such a slow global phase-out is not voluntarily effected, the end of the present cheap uranium supply situation will be unavoidable. The result will be that some countries will simply be unable to afford sufficient uranium fuel at that point, which implies involuntary and perhaps chaotic nuclear phase-outs in those countries involving brownouts, blackouts, and worse

  15. GRACE Status at Mission End

    Tapley, B. D.; Flechtner, F. M.; Watkins, M. M.; Bettadpur, S. V.

    2017-12-01

    The twin satellites of the Gravity Recovery and Climate Experiment (GRACE) were launched on March 17, 2002 and have operated for nearly 16 years. The mission objectives are to observe the spatial and temporal variations of the Earth's mass through its effects on the gravity field at the GRACE satellite altitude. The mass changes observed are related to both the changes within the solid earth and the change within and between the Erath system components. A significant cause of the time varying mass is water motion and the GRACE mission has provided a continuous decade long measurement sequence which characterizes the seasonal cycle of mass transport between the oceans, land, cryosphere and atmosphere; its inter-annual variability; and the climate driven secular, or long period, mass transport signals. The fifth reanalysis on the mission data set, the RL05 data, were released in mid-2013. With the planned launch of GRACE Follow-On in early 2018, plans are underway for a reanalysis that will be consistent with the GRACE FO processing standards. The mission is entering the final phases of its operation life with mission end expected to occur in early 2018. The current mission operations strategy emphasizes extending the mission lifetime to obtain an overlap with the GRACE FO. This presentation will review the mission status and the projections for mission lifetime, describe the current operations philosophy and its impact on the science data, discuss the issues related to achieving the GRACE and GRACE FO connection and discuss issues related to science data products during this phase of the mission period.

  16. Circular myotomy as an aid to resection and end-to-end anastomosis of the esophagus.

    Attum, A A; Hankins, J R; Ngangana, J; McLaughlin, J S

    1979-08-01

    Segments ranging from 40 to 70% of the thoracic esophagus were resected in 80 mongrel dogs. End-to-end anastomosis was effected after circular myotomy either proximal or distal, or both proximal and distal, to the anastomosis. Among dogs undergoing resection of 60% of the esophagus, distal myotomy enabled 6 of 8 animals to survive, and combined proximal and distal myotomy permitted 8 of 10 to survive. Cineesophagography was performed in a majority of the 50 surviving animals and showed no appreciable delay of peristalsis at the myotomy sites. When these sites were examined at postmortem examination up to 13 months after operation, 1 dog showed a small diverticulum but none showed dilatation or stricture. It is concluded that circular myotomy holds real promise as a means of extending the clinical application of esophageal resection with end-to-end anastomosis.

  17. End-to-End Operations in the ELT Era

    Hainaut, O. R.; Bierwirth, T.; Brillant, S.; Mieske, S.; Patat, F.; Rejkuba, M.; Romaniello, M.; Sterzik, M.

    2018-03-01

    The Data Flow System is the infrastructure on which Very Large Telescope (VLT) observations are performed at the Observatory, before and after the observations themselves take place. Since its original conception in the late 1990s, it has evolved to accommodate new observing modes and new instruments on La Silla and Paranal. Several updates and upgrades are needed to overcome its obsolescence and to integrate requirements from the new instruments from the community and, of course, from ESO's Extremely Large Telescope (ELT), which will be integrated into Paranal's operations. We describe the end-to-end operations and the resulting roadmap guiding their further development.

  18. End-to-end plasma bubble PIC simulations on GPUs

    Germaschewski, Kai; Fox, William; Matteucci, Jackson; Bhattacharjee, Amitava

    2017-10-01

    Accelerator technologies play a crucial role in eventually achieving exascale computing capabilities. The current and upcoming leadership machines at ORNL (Titan and Summit) employ Nvidia GPUs, which provide vast computational power but also need specifically adapted computational kernels to fully exploit them. In this work, we will show end-to-end particle-in-cell simulations of the formation, evolution and coalescence of laser-generated plasma bubbles. This work showcases the GPU capabilities of the PSC particle-in-cell code, which has been adapted for this problem to support particle injection, a heating operator and a collision operator on GPUs.

  19. Finite Larmor radius flute mode theory with end loss

    Kotelnikov, I.A.; Berk, H.L.

    1993-08-01

    The theory of flute mode stability is developed for a two-energy- component plasma partially terminated by a conducting limiter. The formalism is developed as a preliminary study of the effect of end-loss in open-ended mirror machines where large Larmor radius effects are important

  20. Integrating emotional and psychological support into the end-stage renal disease pathway: a protocol for mixed methods research to identify patients' lower-level support needs and how these can most effectively be addressed.

    Taylor, Francesca; Taylor, Celia; Baharani, Jyoti; Nicholas, Johann; Combes, Gill

    2016-08-02

    As a result of difficulties related to their illness, diagnosis and treatment, patients with end-stage renal disease experience significant emotional and psychological problems, which untreated can have considerable negative impact on their health and wellbeing. Despite evidence that patients desire improved support, management of their psychosocial problems, particularly at the lower-level, remains sub-optimal. There is limited understanding of the specific support that patients need and want, from whom, and when, and also a lack of data on what helps and hinders renal staff in identifying and responding to their patients' support needs, and how barriers to doing so might be overcome. Through this research we therefore seek to determine what, when, and how, support for patients with lower-level emotional and psychological problems should be integrated into the end-stage renal disease pathway. The research will involve two linked, multicentre studies, designed to identify and consider the perspectives of patients at five different stages of the end-stage renal disease pathway (Study 1), and renal staff working with them (Study 2). A convergent, parallel mixed methods design will be employed for both studies, with quantitative and qualitative data collected separately. For each study, the data sets will be analysed separately and the results then compared or combined using interpretive analysis. A further stage of synthesis will employ data-driven thematic analysis to identify: triangulation and frequency of themes across pathway stages; patterns and plausible explanations of effects. There is an important need for this research given the high frequency of lower-level distress experienced by end-stage renal disease patients and lack of progress to date in integrating support for their lower-level psychosocial needs into the care pathway. Use of a mixed methods design across the two studies will generate a holistic patient and healthcare professional perspective that

  1. Magnet pole shape design for reduction of thrust ripple of slotless permanent magnet linear synchronous motor with arc-shaped magnets considering end-effect based on analytical method

    Kyung-Hun Shin

    2017-05-01

    Full Text Available The shape of the magnet is essential to the performance of a slotless permanent magnet linear synchronous machine (PMLSM because it is directly related to desirable machine performance. This paper presents a reduction in the thrust ripple of a PMLSM through the use of arc-shaped magnets based on electromagnetic field theory. The magnetic field solutions were obtained by considering end effect using a magnetic vector potential and two-dimensional Cartesian coordinate system. The analytical solution of each subdomain (PM, air-gap, coil, and end region is derived, and the field solution is obtained by applying the boundary and interface conditions between the subdomains. In particular, an analytical method was derived for the instantaneous thrust and thrust ripple reduction of a PMLSM with arc-shaped magnets. In order to demonstrate the validity of the analytical results, the back electromotive force results of a finite element analysis and experiment on the manufactured prototype model were compared. The optimal point for thrust ripple minimization is suggested.

  2. Pomegranate (Punicagranatum juice decreases lipid peroxidation, but has no effect on plasma advanced glycated end-products in adults with type 2 diabetes: a randomized double-blind clinical trial

    Golbon Sohrab

    2015-09-01

    Full Text Available Introduction: Diabetes mellitus characterized by hyperglycemia could increase oxidative stress and formation of advanced glycated end-products (AGEs, which contribute to diabetic complications. The purpose of this study was to assess the effect of pomegranate juice (PJ containing natural antioxidant on lipid peroxidation and plasma AGEs in patients with type 2 diabetes (T2D. Materials and methods: In a randomized, double-blind, placebo-controlled trial, 44 patients (age range 56±6.8 years, T2D were randomly assigned to one of two groups: group A (PJ, n=22 and group B (Placebo, n=22. At the baseline and the end of 12-week intervention, biochemical markers including fasting plasma glucose, insulin, oxidative stress, and AGE markers including carboxy methyl lysine (CML and pentosidine were assayed. Results: At baseline, there were no significant differences in plasma total antioxidant capacity (TAC levels between the two groups, but malondialdehyde (MDA decreased levels were significantly different (P<0.001. After 12 weeks of intervention, TAC increased (P<0.05 and MDA decreased (P<0.01 in the PJ group when compared with the placebo group. However, no significant differences were observed in plasma concentration of CML and pentosidine between the two groups. Conclusions: The study showed that PJ decreases lipid peroxidation. Therefore, PJ consumption may delay onset of T2D complications related to oxidative stress.

  3. Cyberinfrastructure for End-to-End Environmental Explorations

    Merwade, V.; Kumar, S.; Song, C.; Zhao, L.; Govindaraju, R.; Niyogi, D.

    2007-12-01

    The design and implementation of a cyberinfrastructure for End-to-End Environmental Exploration (C4E4) is presented. The C4E4 framework addresses the need for an integrated data/computation platform for studying broad environmental impacts by combining heterogeneous data resources with state-of-the-art modeling and visualization tools. With Purdue being a TeraGrid Resource Provider, C4E4 builds on top of the Purdue TeraGrid data management system and Grid resources, and integrates them through a service-oriented workflow system. It allows researchers to construct environmental workflows for data discovery, access, transformation, modeling, and visualization. Using the C4E4 framework, we have implemented an end-to-end SWAT simulation and analysis workflow that connects our TeraGrid data and computation resources. It enables researchers to conduct comprehensive studies on the impact of land management practices in the St. Joseph watershed using data from various sources in hydrologic, atmospheric, agricultural, and other related disciplines.

  4. The End of ‘the end of impunity’?

    Holtermann, Jakob von Holderstein

    2010-01-01

    With its express intention ‘to put an end to impunity’, the International Criminal Court (ICC) faces a substantial challenge in the shape of conditional amnesties granted in future national truth commissions (TCs)—a challenge that invokes fundamental considerations of criminal justice ethics...

  5. Network analysis on skype end-to-end video quality

    Exarchakos, Georgios; Druda, Luca; Menkovski, Vlado; Liotta, Antonio

    2015-01-01

    Purpose – This paper aims to argue on the efficiency of Quality of Service (QoS)-based adaptive streamingwith regards to perceived quality Quality of Experience (QoE). Although QoS parameters are extensivelyused even by high-end adaptive streaming algorithms, achieved QoE fails to justify their use

  6. Analysis of Co-Effects on Air Pollutants and CO2 Emissions Generated by End-of-Pipe Measures of Pollution Control in China’s Coal-Fired Power Plants

    Haijun Zhao

    2017-03-01

    Full Text Available China is now facing great challenges resulting from climate change and air pollution, driven by the processes of industrialization and urbanization. Greenhouse gas and air pollutant emissions produced by the coal-fired power industry represent approximately 70% of the total emissions in China’s industrial sector. In this study, 39 coal-fired power plants built in China between 2014 and 2015 were analyzed in regards to the co-effects oncarbon dioxide and air pollutant emissions generated directly and indirectly by end-of-pipe measures of pollution control. After completing the quantitative analysis with input data from 83units of power plants, we found that co-effects were positive only for air pollutant reductions through the implementation of desulfurization, denitrification, and dedusting measures, but co-effects were negative for carbon dioxide production because of the corresponding electricity use and chemical reactions that led to the increases in carbon dioxide emissions. We also performed an assessment of the synergistic coefficients to better understand the degree of co-effects. It will be important for researchers to take a comprehensive view of China’s coal-fired power plants and look for solutions that can maximize positive co-effects and achieve overall co-benefits of reductions in greenhouse gas emissions and air pollutants.

  7. Year-end seasonality in one-month LIBOR derivatives

    Christopher J. Neely; Drew B. Winters

    2005-01-01

    We examine the markets for one-month LIBOR futures contracts and options on those futures for a year-end price effect consistent with the previously identified year-end rate increase in one-month LIBOR. The cash market rate increase appears in forward rates and derivative prices, which allows the derivatives to properly hedge year-end interest rate risk. However, while the year-end effect appears in the derivative contract, these derivative contracts provide biased forecasts of both future in...

  8. Designing end-user interfaces

    Heaton, N

    1988-01-01

    Designing End-User Interfaces: State of the Art Report focuses on the field of human/computer interaction (HCI) that reviews the design of end-user interfaces.This compilation is divided into two parts. Part I examines specific aspects of the problem in HCI that range from basic definitions of the problem, evaluation of how to look at the problem domain, and fundamental work aimed at introducing human factors into all aspects of the design cycle. Part II consists of six main topics-definition of the problem, psychological and social factors, principles of interface design, computer intelligenc

  9. Nuclear fuel element end fitting

    Jabsen, F.S.

    1979-01-01

    A typical embodiment of the invention has an array of sockets that are welded to the intersections of the plates that form the upper and lower end fittings of a nuclear reactor fuel element. The sockets, which are generally cylindrical in shape, are oriented in directions that enable the longitudinal axes of the sockets to align with the longitudinal axes of the fuel rods that are received in the respective sockets. Detents impressed in the surfaces of the sockets engage mating grooves that are formed in the ends of the fuel rods to provide for the structural integrity of the fuel element

  10. End region detailing of pretensioned concrete bridge girders.

    2013-03-01

    End region detailing has significant effect on the serviceability, behavior, and capacity of pretensioned concrete girders. : In this project, experimental and analytical research programs were conducted to evaluate and quantify the effects of : diff...

  11. Means and ends of control

    Lind, Morten

    2004-01-01

    assumptions. Means-end analysis also lacks a proper definition of the control concept. It is proposed that control is defined as a binary relation that assign functional roles to subsystems. This control concept leads to distinct but entangled process and control hierarchies. It is argued that the problems...

  12. Open-Ended Electric Motor

    Gould, Mauri

    1975-01-01

    Presents complete instructions for assembling an electric motor which does not require large amounts of power to operate and which is inexpensive as well as reliable. Several open-ended experiments with the motor are included as well as information for obtaining a kit of parts and instructions. (BR)

  13. Align the Front End First.

    Perry, Jim

    1995-01-01

    Discussion of management styles and front-end analysis focuses on a review of Douglas McGregor's theories. Topics include Theories X, Y, and Z; leadership skills; motivational needs of employees; intrinsic and extrinsic rewards; and faulty implementation of instructional systems design processes. (LRW)

  14. End of Life: An Overview

    Toner, Mary Ann; Shadden, Barbara B.

    2012-01-01

    Speech-language pathologists (SLPs) provide services to patients confronting the end of life (EOL) in a variety of settings. Instead of targeting improvement of health or sustaining life, EOL services focus primarily on quality of life. Although SLPs may not consider themselves core members of the health care team providing EOL services, the…

  15. Doubled-ended ceramic thyratron

    1974-01-01

    The double-ended ceramic thyratron CX 1171 B, with its coaxial voltage divider for the SPS. Such a switch, paralleled by three ignitrons in series forms the "thyragnitron" arrangement, and can switch 10 kA, 25 ms pulses, with very fast rise times.

  16. An end to end secure CBIR over encrypted medical database.

    Bellafqira, Reda; Coatrieux, Gouenou; Bouslimi, Dalel; Quellec, Gwenole

    2016-08-01

    In this paper, we propose a new secure content based image retrieval (SCBIR) system adapted to the cloud framework. This solution allows a physician to retrieve images of similar content within an outsourced and encrypted image database, without decrypting them. Contrarily to actual CBIR approaches in the encrypted domain, the originality of the proposed scheme stands on the fact that the features extracted from the encrypted images are themselves encrypted. This is achieved by means of homomorphic encryption and two non-colluding servers, we however both consider as honest but curious. In that way an end to end secure CBIR process is ensured. Experimental results carried out on a diabetic retinopathy database encrypted with the Paillier cryptosystem indicate that our SCBIR achieves retrieval performance as good as if images were processed in their non-encrypted form.

  17. Increasing operations profitability using an end-to-end, wireless internet, gas monitoring system

    McDougall, M. [Northrock Resources Ltd., AB (Canada); Benterud, K. [zed.i solutions, inc., Calgary, AB (Canada)

    2004-10-01

    Implementation by Northrock Resources Ltd., a wholly-owned subsidiary of Unocal Corporation, of a fully integrated end-to-end gas measurement and production analysis system, is discussed. The system, dubbed Smart-Alek(TM), utilizes public wireless communications and a web browser only delivery system to provide seamless well visibility to a desk-top computer. Smart-Alek(TM) is an example of a new type of end-to-end electronic gas flow measurement system, known as FINE(TM), which is an acronym for Field Intelligence Network and End-User Interface. The system delivers easy-to-use, complete, reliable and cost effective production information, far more effective than is possible to obtain with conventional SCADA technology. By installing the system, Northrock was able to increase gas volumes with more accurate electronic flow measurement in place of mechanical charts, with very low technical maintenance, and at a reduced operating cost. It is emphasized that deploying the technology alone will produce only partial benefits; to realize full benefits it is also essential to change grass roots operating practices, aiming at timely decision-making at the field level. 5 refs., 5 figs.

  18. Cheating at the end to avoid regret.

    Effron, Daniel A; Bryan, Christopher J; Murnighan, J Keith

    2015-09-01

    How do people behave when they face a finite series of opportunities to cheat with little or no risk of detection? In 4 experiments and a small meta-analysis, we analyzed over 25,000 cheating opportunities faced by over 2,500 people. The results suggested that the odds of cheating are almost 3 times higher at the end of a series than earlier. Participants could cheat in 1 of 2 ways: They could lie about the outcome of a private coin flip to get a payoff that they would otherwise not receive (Studies 1-3) or they could overbill for their work (Study 4). We manipulated the number of cheating opportunities they expected but held the actual number of opportunities constant. The data showed that the likelihood of cheating and the extent of dishonesty were both greater when people believed that they were facing a last choice. Mediation analyses suggested that anticipatory regret about passing up a chance to enrich oneself drove this cheat-at-the-end effect. We found no support for alternative explanations based on the possibility that multiple cheating opportunities depleted people's self-control, eroded their moral standards, or made them feel that they had earned the right to cheat. The data also suggested that the cheat-at-the-end effect may be limited to relatively short series of cheating opportunities (i.e., n < 20). Our discussion addresses the psychological and behavioral dynamics of repeated ethical choices. (c) 2015 APA, all rights reserved).

  19. Effects of Methicillin-Resistant Staphylococcus aureus/Multiresistant Gram-Negative Bacteria Colonization or Infection and Isolation Measures in End of Life on Family Caregivers: Results of a Qualitative Study.

    Heckel, Maria; Sturm, Alexander; Herbst, Franziska A; Ostgathe, Christoph; Stiel, Stephanie

    2017-03-01

    Little is known about the experiences of family caregivers of hospitalized patients with confirmed methicillin-resistant Staphylococcus aureus/multiresistant gram-negative bacteria (MRSA/MRGN) diagnosis at the end of life. The study at hand is a subproject of an interdisciplinary cooperation project that aims at developing a patient-, family-, and team-centered approach in dealing with MRSA/MRGN-positive hospitalized patients in palliative and geriatric care. The present study aimed to assess the individual effects of the patient's MRSA/MRGN colonization or infection and isolation measures on family caregivers. Between April 2014 and September 2015, all known family caregivers associated with an MRSA/MRGN-positive patient from a palliative care unit, a hospital palliative care support team, and a geriatric ward were considered for study participation. A qualitative interview study with family caregivers and an additional focus group was conducted. Data were analyzed using the principles of Grounded Theory. Family caregivers (N = 62) raised suggestions regarding the provision of information and communication on the MRSA/MRGN diagnosis and hygiene measures from staff members and the consistency of hygiene procedures. Family caregivers requested not to be stigmatized or being disadvantaged due to the MRSA/MRGN diagnosis of the patient, and they wished to receive psychosocial and emotional support. Staff members and institutional stakeholders should be aware that family caregivers might be burdened and upset by positive MRSA/MRGN diagnosis and the required hygiene measures. The need for detailed and understandable information on MRSA/MRGN, adequate communication between staff members and family caregivers, and support for family caregivers should be of special attention in particular in end-of-life care.

  20. Validation of intermediate end points in cancer research.

    Schatzkin, A; Freedman, L S; Schiffman, M H; Dawsey, S M

    1990-11-21

    Investigations using intermediate end points as cancer surrogates are quicker, smaller, and less expensive than studies that use malignancy as the end point. We present a strategy for determining whether a given biomarker is a valid intermediate end point between an exposure and incidence of cancer. Candidate intermediate end points may be selected from case series, ecologic studies, and animal experiments. Prospective cohort and sometimes case-control studies may be used to quantify the intermediate end point-cancer association. The most appropriate measure of this association is the attributable proportion. The intermediate end point is a valid cancer surrogate if the attributable proportion is close to 1.0, but not if it is close to 0. Usually, the attributable proportion is close to neither 1.0 nor 0; in this case, valid surrogacy requires that the intermediate end point mediate an established exposure-cancer relation. This would in turn imply that the exposure effect would vanish if adjusted for the intermediate end point. We discuss the relative advantages of intervention and observational studies for the validation of intermediate end points. This validation strategy also may be applied to intermediate end points for adverse reproductive outcomes and chronic diseases other than cancer.

  1. Adaptive RF front-ends for hand-held applications

    van Bezooijen, Andre; van Roermund, Arthur

    2010-01-01

    The RF front-end - antenna combination is a vital part of a mobile phone because its performance is very relevant to the link quality between hand-set and cellular network base-stations. The RF front-end performance suffers from changes in operating environment, like hand-effects, that are often unpredictable. ""Adaptive RF Front-Ends for Hand-Held Applications"" presents an analysis on the impact of fluctuating environmental parameters. In order to overcome undesired behavior two different adaptive control methods are treated that make RF frond-ends more resilient: adaptive impedance control,

  2. NORTH END ROADLESS AREA, ARIZONA.

    Drewes, Harald; Bigsby, P.R.

    1984-01-01

    Studies conducted in the North End Roadless Area, Arizona indicate probable or substantiated metallic mineral-resource potential in about one-fifth of the area. The area has potential for disseminated or stockwork-type molybdenum mineralization, copper-lead-zinc-silver veins, lead-zinc-silver limestone replacement deposits, and tungsten-bearing contact metamorphic skarn deposits. The area also contains cement rock and marble dimension stone, but has only slight promise for the occurrence of petroleum and natural gas.

  3. Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells

    Tanaka, Ken-ichiro, E-mail: ken1nai@med.shimane-u.ac.jp; Yamaguchi, Toru, E-mail: yamaguch@med.shimane-u.ac.jp; Kanazawa, Ippei, E-mail: ippei.k@med.shimane-u.ac.jp; Sugimoto, Toshitsugu, E-mail: sugimoto@med.shimane-u.ac.jp

    2015-05-29

    In diabetes mellitus (DM), high glucose (HG) and advanced glycation end products (AGEs) are involved in bone quality deterioration. Osteocytes produce sclerostin and receptor activator of nuclear factor-kB ligand (RANKL) and regulate osteoblast and osteoclast function. However, whether HG or AGEs directly affect osteocytes and regulate sclerostin and RANKL production is unknown. Here, we examined the effects of HG, AGE2, and AGE3 on the expression of sclerostin and RANKL and on apoptosis in osteocyte-like MLO-Y4-A2 cells. Treatment of the cells with 22 mM glucose, 100 μg/mL either AGE2 or AGE3 significantly increased the expression of sclerostin protein and mRNA; however, both AGEs, but not glucose, significantly decreased the expression of RANKL protein and mRNA. Moreover, treatment of the cells with HG, AGE2, or AGE3 for 72 h induced significant apoptosis. These detrimental effects of HG, AGE2, and AGE3 on sclerostin and RANKL expressions and on apoptosis were antagonized by pretreatment of the cells with 10{sup −8} M human parathyroid hormone (PTH)-(1–34). Thus, HG and AGEs likely suppress bone formation by increasing sclerostin expression in osteocytes, whereas AGEs suppress bone resorption by decreasing RANKL expression. Together, these processes may cause low bone turnover in DM. In addition, HG and AGEs may cause cortical bone deterioration by inducing osteocyte apoptosis. PTH may effectively treat these pathological processes and improve osteocyte function. - Highlights: • AGEs are involved in bone quality deterioration in diabetes mellitus (DM). • AGEs increased sclerostin as well as apoptosis, and decreased RANKL in osteocytes. • The effects of AGEs on osteocyte function were antagonized by human PTH-(1–34). • AGEs may cause low bone turnover and cortical porosity in DM. • PTH may be effective in bone quality deterioration by improving osteocyte function.

  4. FDTD analysis of open-ended dielectric sensors

    Anderson, J.; Okoniewski, M.; Stuchly, S.S. [Univ. of Victoria (Canada)

    1994-12-31

    The reflection coefficient of an open-ended coaxial line immersed in water and methanol is simulated using a modified FDTD code. Calculated values are compared with previously obtained moment method and experimental values. The effects of variations in the end of line geometry on the reflection coefficient are investigated.

  5. Appendix F : finite element analysis of end region.

    2013-03-01

    FE (finite element) modeling was conducted to 1) provide a better understanding of the : elastic behavior of the end region prior to cracking and 2) to evaluate the effects of bearing pad : stiffness and width on end region elastic stresses. The FEA ...

  6. End to end adaptive congestion control in TCP/IP networks

    Houmkozlis, Christos N

    2012-01-01

    This book provides an adaptive control theory perspective on designing congestion controls for packet-switching networks. Relevant to a wide range of disciplines and industries, including the music industry, computers, image trading, and virtual groups, the text extensively discusses source oriented, or end to end, congestion control algorithms. The book empowers readers with clear understanding of the characteristics of packet-switching networks and their effects on system stability and performance. It provides schemes capable of controlling congestion and fairness and presents real-world app

  7. End-to-End Assessment of a Large Aperture Segmented Ultraviolet Optical Infrared (UVOIR) Telescope Architecture

    Feinberg, Lee; Bolcar, Matt; Liu, Alice; Guyon, Olivier; Stark,Chris; Arenberg, Jon

    2016-01-01

    Key challenges of a future large aperture, segmented Ultraviolet Optical Infrared (UVOIR) Telescope capable of performing a spectroscopic survey of hundreds of Exoplanets will be sufficient stability to achieve 10-10 contrast measurements and sufficient throughput and sensitivity for high yield Exo-Earth spectroscopic detection. Our team has collectively assessed an optimized end to end architecture including a high throughput coronagraph capable of working with a segmented telescope, a cost-effective and heritage based stable segmented telescope, a control architecture that minimizes the amount of new technologies, and an Exo-Earth yield assessment to evaluate potential performance.

  8. Esophageal Resection for End-Stage Achalasia.

    Aiolfi, Alberto; Asti, Emanuele; Bonitta, Gianluca; Siboni, Stefano; Bonavina, Luigi

    2018-04-01

    Achalasia is a rare disease characterized by impaired lower esophageal sphincter relaxation loss and of peristalsis in the esophageal body. Endoscopic balloon dilation and laparoscopic surgical myotomy have been established as initial treatment modalities. Indications and outcomes of esophagectomy in the management of end-stage achalasia are less defined. A literature search was conducted to identify all reports on esophagectomy for end-stage achalasia between 1987 and 2017. MEDLINE, Embase, and Cochrane databases were consulted matching the terms "achalasia," "end-stage achalasia," "esophagectomy," and "esophageal resection." Seventeen articles met the inclusion criteria and 1422 patients were included in this narrative review. Most of the patients had previous multiple endoscopic and/or surgical treatments. Esophagectomy was performed through a transthoracic (74%) or a transhiatal (26%) approach. A thoracoscopic approach was used in a minority of patients and seemed to be safe and effective. In 95 per cent of patients, the stomach was used as an esophageal substitute. The mean postoperative morbidity rate was 27.1 per cent and the mortality rate 2.1 per cent. Symptom resolution was reported in 75 to 100 per cent of patients over a mean follow-up of 43 months. Only five series including 195 patients assessed the long-term follow-up (>5 years) after reconstruction with gastric or colon conduits, and the results seem similar. Esophagectomy for end-stage achalasia is safe and effective in tertiary referral centers. A thoracoscopic approach is a feasible and safe alternative to thoracotomy and may replace the transhiatal route in the future.

  9. UO3 deactivation end point criteria

    Stefanski, L.D.

    1994-01-01

    The UO 3 Deactivation End Point Criteria are necessary to facilitate the transfer of the UO 3 Facility from the Office of Facility Transition and Management (EM-60) to the office of Environmental Restoration (EM-40). The criteria were derived from a logical process for determining end points for the systems and spaces at the UO 3 , Facility based on the objectives, tasks, and expected future uses pertinent to that system or space. Furthermore, the established criteria meets the intent and supports the draft guidance for acceptance criteria prepared by EM-40, open-quotes U.S. Department of Energy office of Environmental Restoration (EM-40) Decontamination and Decommissioning Guidance Document (Draft).close quotes For the UO 3 Facility, the overall objective of deactivation is to achieve a safe, stable and environmentally sound condition, suitable for an extended period, as quickly and economically as possible. Once deactivated, the facility is kept in its stable condition by means of a methodical surveillance and maintenance (S ampersand M) program, pending ultimate decontamination and decommissioning (D ampersand D). Deactivation work involves a range of tasks, such as removal of hazardous material, elimination or shielding of radiation fields, partial decontamination to permit access for inspection, installation of monitors and alarms, etc. it is important that the end point of each of these tasks be established clearly and in advance, for the following reasons: (1) End points must be such that the central element of the deactivation objective - to achieve stability - is unquestionably achieved. (2) Much of the deactivation work involves worker exposure to radiation or dangerous materials. This can be minimized by avoiding unnecessary work. (3) Each task is, in effect, competing for resources with other deactivation tasks and other facilities. By assuring that each task is appropriately bounded, DOE's overall resources can be used most fully and effectively

  10. SSC collider dipole magnet end mechanical design

    Delchamps, S.W.; Bossert, R.C.; Carson, J.; Ewald, K.; Fulton, H.; Kerby, J.; Koska, W.; Strait, J.; Wake, M.; Leung, K.K.

    1991-01-01

    This paper describes the mechanical design of the ends of Superconducting Super Collider dipole magnets to be constructed and tested at Fermilab. Coil end clamps, end yoke configuration, and end plate design are discussed. Loading of the end plate by axial Lorentz forces is discussed. Relevant data from 40 mm and 50 mm aperture model dipole magnets built and tested at Fermilab are presented. In particular, the apparent influence of end clamp design on the quench behavior of model SSC dipoles is described

  11. [Effect of Debriefing Based on the Clinical Judgment Model on Simulation Based Learning Outcomes of End-of-Life Care for Nursing Students: A Non-Randomized Controlled Trial].

    Jeong, Kyung In; Choi, Ja Yun

    2017-12-01

    This study was conducted to identify effects of debriefing based on the clinical judgment model for nursing students on their knowledge, skill performance, clinical judgment, self-confidence and learner satisfaction during simulation based end-of-life care (ELC) education. Simulation based ELC education was developed in six steps as follows: selection of learning subjects and objects, development of learning tools, a trial run of simulation-based education, students' skill training, and evaluators' training. Forty-eight senior nursing students (25 in the experimental group and 23 in the control group) participated in the simulation-based ELC education using a high-fidelity simulator. Debriefing based on the clinical judgment was compared with the usual debriefing. ANCOVA showed that there were differences in knowledge (F=4.81, p=.034), skill performance (F=68.33, psatisfaction (t=-0.38, p=.704) between the experimental and control groups. This study found that debriefing based on the clinical judgement model is effective for supporting nursing students for reflecting on clinical judgment and improving their diverse competencies in complex clinical settings such as ELC. © 2017 Korean Society of Nursing Science

  12. End-to-End Adversarial Retinal Image Synthesis.

    Costa, Pedro; Galdran, Adrian; Meyer, Maria Ines; Niemeijer, Meindert; Abramoff, Michael; Mendonca, Ana Maria; Campilho, Aurelio

    2018-03-01

    In medical image analysis applications, the availability of the large amounts of annotated data is becoming increasingly critical. However, annotated medical data is often scarce and costly to obtain. In this paper, we address the problem of synthesizing retinal color images by applying recent techniques based on adversarial learning. In this setting, a generative model is trained to maximize a loss function provided by a second model attempting to classify its output into real or synthetic. In particular, we propose to implement an adversarial autoencoder for the task of retinal vessel network synthesis. We use the generated vessel trees as an intermediate stage for the generation of color retinal images, which is accomplished with a generative adversarial network. Both models require the optimization of almost everywhere differentiable loss functions, which allows us to train them jointly. The resulting model offers an end-to-end retinal image synthesis system capable of generating as many retinal images as the user requires, with their corresponding vessel networks, by sampling from a simple probability distribution that we impose to the associated latent space. We show that the learned latent space contains a well-defined semantic structure, implying that we can perform calculations in the space of retinal images, e.g., smoothly interpolating new data points between two retinal images. Visual and quantitative results demonstrate that the synthesized images are substantially different from those in the training set, while being also anatomically consistent and displaying a reasonable visual quality.

  13. The End of Bank Secrecy?

    Johannesen, Niels; Zucman, Gabriel

    2014-01-01

    the treaties affected bank deposits in tax havens. Rather than repatriating funds, our results suggest that tax evaders shifted deposits to havens not covered by a treaty with their home country. The crackdown thus caused a relocation of deposits at the benefit of the least compliant havens. We discuss......During the financial crisis, G20 countries compelled tax havens to sign bilateral treaties providing for exchange of bank information. Policymakers have celebrated this global initiative as the end of bank secrecy. Exploiting a unique panel dataset, our study is the first attempt to assess how...

  14. FAMS DECOMMISSIONING END-STATE ALTERNATIVE EVALUATION

    Grimm, B; Stephen Chostner, S; Brenda Green, B

    2006-01-01

    Nuclear Material Management (NMM) completed a comprehensive study at the request of the Department of Energy Savannah River Operations Office (DOE-SR) in 2004 (Reference 11.1). The study evaluated the feasibility of removal and/or mitigation of the Pu-238 source term in the F-Area Material Storage (FAMS) facility during on-going material storage operations. The study recommended different options to remove and/or mitigate the Pu-238 source term depending on its location within the facility. During April 2005, the Department of Energy (DOE) sent a letter of direction (LOD) to Washington Savannah River Company (WSRC) directing WSRC to implement a new program direction that would enable an accelerated shutdown and decommissioning of FAMS (Reference 11.2). Further direction in the LOD stated that effective December 1, 2006 the facility will be transitioned to begin deactivation and decommissioning (D and D) activities. To implement the LOD, Site D and D (SDD) and DOE agreed the planning end-state would be demolition of the FAMS structure to the building slab. SDD developed the D and D strategy, preliminary cost and schedule, and issued the deactivation project plan in December 2005 (Reference 11.3). Due to concerns and questions regarding the FAMS planning end-state and in support of the project's Critical Decision 1, an alternative study was performed to evaluate the various decommissioning end-states and the methods by which those end-states are achieved. This report documents the results of the alternative evaluation which was performed in a structured decision-making process as outlined in the E7 Manual, Procedure 2.15, ''Alternative Studies'' (Reference 11.4)

  15. Historical clinical and economic consequences of anemia management in patients with end-stage renal disease on dialysis using erythropoietin stimulating agents versus routine blood transfusions: a retrospective cost-effectiveness analysis.

    Naci, Huseyin; de Lissovoy, Gregory; Hollenbeak, Christopher; Custer, Brian; Hofmann, Axel; McClellan, William; Gitlin, Matthew

    2012-01-01

    To determine whether Medicare's decision to cover routine administration of erythropoietin stimulating agents (ESAs) to treat anemia of end-stage renal disease (ESRD) has been a cost-effective policy relative to standard of care at the time. The authors used summary statistics from the actual cohort of ESRD patients receiving ESAs between 1995 and 2004 to create a simulated patient cohort, which was compared with a comparable simulated cohort assumed to rely solely on blood transfusions. Outcomes modeled from the Medicare perspective included estimated treatment costs, life-years gained, and quality-adjusted life-years (QALYs). Incremental cost-effectiveness ratio (ICER) was calculated relative to the hypothetical reference case of no ESA use in the transfusion cohort. Sensitivity of the results to model assumptions was tested using one-way and probabilistic sensitivity analyses. Estimated total costs incurred by the ESRD population were $155.47B for the cohort receiving ESAs and $155.22B for the cohort receiving routine blood transfusions. Estimated QALYs were 2.56M and 2.29M, respectively, for the two groups. The ICER of ESAs compared to routine blood transfusions was estimated as $873 per QALY gained. The model was sensitive to a number of parameters according to one-way and probabilistic sensitivity analyses. This model was counter-factual as the actual comparison group, whose anemia was managed via transfusion and iron supplements, rapidly disappeared following introduction of ESAs. In addition, a large number of model parameters were obtained from observational studies due to the lack of randomized trial evidence in the literature. This study indicates that Medicare's coverage of ESAs appears to have been cost effective based on commonly accepted levels of willingness-to-pay. The ESRD population achieved substantial clinical benefit at a reasonable cost to society.

  16. A Bayes Theory-Based Modeling Algorithm to End-to-end Network Traffic

    Zhao Hong-hao; Meng Fan-bo; Zhao Si-wen; Zhao Si-hang; Lu Yi

    2016-01-01

    Recently, network traffic has exponentially increasing due to all kind of applications, such as mobile Internet, smart cities, smart transportations, Internet of things, and so on. the end-to-end network traffic becomes more important for traffic engineering. Usually end-to-end traffic estimation is highly difficult. This paper proposes a Bayes theory-based method to model the end-to-end network traffic. Firstly, the end-to-end network traffic is described as a independent identically distrib...

  17. An optimum cold end configuration for helium liquefaction cycles

    Minta, M.; Smith, J.L.

    1984-01-01

    This chapter examines the effect of the non-ideal behavior of helium at low temperature on the performance of helium liquefaction cycles. The effect is isolated by means of a continuum model for the precooling stage. The cold end losses are due primarily to the composite effect of the non-ideality of helium at low temperatures and the heat exchanger losses, in addition to the component losses fixed by the expander/compressor efficiencies. Topics considered include continuously distributed full-pressure ratio expanders, continuously distributed full-flow expanders, the heat exchange effect (ideal gas working fluid, real gas working fluid), and cold end configuration. The cold end configuration minimizes the cycle cold end losses

  18. Effect of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L. (Oxalidaceae) roots, on advanced glycation end-product-mediated renal injury in type 2 diabetic KKAy mice.

    Zheng, Ni; Lin, Xing; Wen, Qingwei; Kintoko; Zhang, Shijun; Huang, Jianchun; Xu, Xiaohui; Huang, Renbin

    2013-05-10

    The roots of Averrhoa carambola L. (Oxalidaceae) have a long history of medical use in traditional Chinese medicine for treating diabetes and diabetic nephropathy. 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD) was isolated from the tuberous roots of A. carambola L. The purpose of this study was to investigate the beneficial effect of DMDD on the advanced glycation end-product-mediated renal injury in type 2 diabetic KKAy mice with regard to prove its efficacy by local traditional practitioners in the treatment of kidney frailties in diabetics. KKAy mice were orally administrated DMDD (12.5, 25, 50mg/kg body weight/d) or aminoguanidine (200mg/kg body weight/d) for 8 weeks. Hyperglycemia, renal AGE formation, and the expression of related proteins, such as the AGE receptor, nuclear factor-κB, transforming growth factor-β1, and N(ε)-(carboxymethyl)lysine, were markedly decreased by DMDD. Diabetes-dependent alterations in proteinuria, serum creatinine, creatinine clearance, and serum urea-N and glomerular mesangial matrix expansion were attenuated after treatment with DMDD for 8 weeks. The activities of superoxide dismutase and glutathione peroxidase, which are reduced in the kidneys of KKAy mice, were enhanced by DMDD. These findings suggest that DMDD may inhibit the progression of diabetic nephropathy and may be a therapeutic agent for regulating several pharmacological targets to treat or prevent of diabetic nephropathy. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  19. Healthcare Energy End-Use Monitoring

    Sheppy, M.; Pless, S.; Kung, F.

    2014-08-01

    NREL partnered with two hospitals (MGH and SUNY UMU) to collect data on the energy used for multiple thermal and electrical end-use categories, including preheat, heating, and reheat; humidification; service water heating; cooling; fans; pumps; lighting; and select plug and process loads. Additional data from medical office buildings were provided for an analysis focused on plug loads. Facility managers, energy managers, and engineers in the healthcare sector will be able to use these results to more effectively prioritize and refine the scope of investments in new metering and energy audits.

  20. Outcome of end-to-end urethroplasty in post-traumatic stricture of posterior urethra.

    Hussain, Akbar; Pansota, Mudassar Saeed; Rasool, Mumtaz; Tabassum, Shafqat Ali; Ahmad, Iftikhar; Saleem, Muhammad Shahzad

    2013-04-01

    To determine the outcome of delayed end-to-end anastomotic urethroplasty in blind post-traumatic stricture of posterior urethra at our setup. Case series. Department of Urology and Renal Transplantation, Quaid-e-Azam Medical College/Bahawal Victoria Hospital, Bahawalpur, from January 2009 to June 2011. Adult patients with completely obliterated post-traumatic stricture of posterior urethra ≤ 2 cm were included in the study. Patients with post-prostatectomy (TUR-P, TVP) stricture, stricture more than 2 cm in size or patients of stricture with neurogenic bladder and patients with any perineal disease were excluded from the study. Retrograde urethrogram and voiding cysto-urethrogram was done in every patient to assess stricture length and location. Stricture excision and delayed end-to-end anastomosis of urethra with spatulation was performed in every patient. Minimum followup period was 6 months and maximum 18 months. There were 26 cases with road traffic accident (indirect) and 14 had history of fall/direct trauma to perineum or urethra. Majority of the patients (57.5%) were between 16 to 30 years of age. Twelve (30.0%) patients developed complications postoperatively. Early complications of wound infection occurred in 01 (2.5%) patient. Late complications were seen in 11 (27.5%) patients i.e. stricture recurrence in 7 (17.5%), erectile dysfunction in 2 (5.0%), urethrocutaneous fistula and urinary incontinence in one patient (2.5%) each. Success rate was 70.0% initially and 87.5% overall. Delayed end-to-end anastomotic urethroplasty is an effective procedure for traumatic posterior urethral strictures with success rate of about 87.5%.

  1. Outcome of end-to-end urethroplasty in post-traumatic stricture of posterior urethra

    Hussain, A.; Pansota, M. S.; Rasool, M.; Tabassum, S. A.; Ahmad, I.; Saleem, M. S.

    2013-01-01

    Objective: To determine the outcome of delayed end-to-end anastomotic urethroplasty in blind post-traumatic stricture of posterior urethra at our setup. Study Design: Case series. Place and Duration of Study: Department of Urology and Renal Transplantation, Quaid-e-Azam Medical College/ Bahawal Victoria Hospital, Bahawalpur, from January 2009 to June 2011. Methodology: Adult patients with completely obliterated post-traumatic stricture of posterior urethra 2 cm/sup 2/ were included in the study. Patients with post-prostatectomy (TUR-P, TVP) stricture, stricture more than 2 cm in size or patients of stricture with neurogenic bladder and patients with any perineal disease were excluded from the study. Retrograde urethrogram and voiding cysto-urethrogram was done in every patient to assess stricture length and location. Stricture excision and delayed end-to-end anastomosis of urethra with spatulation was performed in every patient. Minimum followup period was 6 months and maximum 18 months. Results: There were 26 cases with road traffic accident (indirect) and 14 had history of fall/direct trauma to perineum or urethra. Majority of the patients (57.5%) were between 16 to 30 years of age. Twelve (30.0%) patients developed complications postoperatively. Early complications of wound infection occurred in 01 (2.5%) patient. Late complications were seen in 11 (27.5%) patients i.e. stricture recurrence in 7 (17.5%), erectile dysfunction in 2 (5.0%), urethrocutaneous fistula and urinary incontinence in one patient (2.5%) each. Success rate was 70.0% initially and 87.5% overall. Conclusion: Delayed end-to-end anastomotic urethroplasty is an effective procedure for traumatic posterior urethral strictures with success rate of about 87.5%. (author)

  2. Outcome of end-to-end urethroplasty in post-traumatic stricture of posterior urethra

    Hussain, A.; Pansota, M. S.; Rasool, M.; Tabassum, S. A.; Ahmad, I.; Saleem, M. S. [Bahawal Victoria Hospital, Bahawalpur (Pakistan). Dept. of Urology

    2013-04-15

    Objective: To determine the outcome of delayed end-to-end anastomotic urethroplasty in blind post-traumatic stricture of posterior urethra at our setup. Study Design: Case series. Place and Duration of Study: Department of Urology and Renal Transplantation, Quaid-e-Azam Medical College/ Bahawal Victoria Hospital, Bahawalpur, from January 2009 to June 2011. Methodology: Adult patients with completely obliterated post-traumatic stricture of posterior urethra 2 cm/sup 2/ were included in the study. Patients with post-prostatectomy (TUR-P, TVP) stricture, stricture more than 2 cm in size or patients of stricture with neurogenic bladder and patients with any perineal disease were excluded from the study. Retrograde urethrogram and voiding cysto-urethrogram was done in every patient to assess stricture length and location. Stricture excision and delayed end-to-end anastomosis of urethra with spatulation was performed in every patient. Minimum followup period was 6 months and maximum 18 months. Results: There were 26 cases with road traffic accident (indirect) and 14 had history of fall/direct trauma to perineum or urethra. Majority of the patients (57.5%) were between 16 to 30 years of age. Twelve (30.0%) patients developed complications postoperatively. Early complications of wound infection occurred in 01 (2.5%) patient. Late complications were seen in 11 (27.5%) patients i.e. stricture recurrence in 7 (17.5%), erectile dysfunction in 2 (5.0%), urethrocutaneous fistula and urinary incontinence in one patient (2.5%) each. Success rate was 70.0% initially and 87.5% overall. Conclusion: Delayed end-to-end anastomotic urethroplasty is an effective procedure for traumatic posterior urethral strictures with success rate of about 87.5%. (author)

  3. Welding nuclear reactor fuel rod end plugs

    Yeo, D.

    1984-01-01

    Apparatus for applying a vacuum to a nuclear fuel rod cladding tube's interior through its open end while girth welding an inserted end plug to its other end. An airtight housing has an orifice with a seal which can hermetically engage the tube's open end. A vacuum hose has one end connected to the housing and the other end connected to a vacuum pump. A mechanized device which moves the housing to engage or disengage its seal with the tube's open end includes at least one arm having one end attached to the housing and the other end pivotally attached to a movable table; an arm rotating device to coaxially align the housing's orifice with the welding-positioned tube; and a table moving device to engage the seal of the coaxially aligned orifice with the tube's open end. (author)

  4. The effects of extreme low frequency pulsed electromagnetic field on bone mineral density and incidence of fractures in patients with end - stage renal disease on dialysis - three year follow up study

    Rakočević-Hrnjak Aleksandra

    2018-01-01

    Full Text Available Background/Aim. A variety of physical therapy options has been developed for the treatment of musculoskeletal disorders including those characterized with low bone mineral density (BMD. Extreme low frequency pulsed electromagnetic field (ELF-PEMF can accelerate bone formation. Patients with end stage of renal disease (ESRD are predisposed to high incidence of fractures due to bone disorder with multifactorial pathogenesis. Vitamin D, calcium supplements, antiresorptive and anabolic drugs in those patients have changed pharmacodynamics and pharmacokinetics and have minimal or limited effects. The aim of this study was to assess the effectiveness of long-term ELF-PEMF therapy applied in concordance with physical exercise on bone mass, incidence of new bone fractures and parathyroid hormone concentrations in ESRD patients on dialysis. Methods. In this 3-year prospective clinical trial, 151 patients with ESRD on dialysis program were subjected to treatment with ELF-PEMF (18 Hz, 2 mT applied during 40 min after 10 consecutive dialysis procedures, 4 times through one year (120 treatments in total during three years together with kinesitherapy (study group or only with kinesitherapy (control group on the voluntary basis. Results. Total of 124 patients have completed the study. In the study group (n = 54, regardless of sex, significant improvements of BMD, T-score and Z-score on both lumbar spine and femoral neck were achieved after 3-year treatment with ELF-PEMF. In the control group (n = 70, significant decreases of BMD, T-score and Z-score as well as the higher incidence of new bone fractures were recorded. Conclusion. ELF-PEMF could be a convenient and safe non-pharmacological therapeutic strategy for fracture prevention in nephrology practices.

  5. Profitable tail-end production

    Pinchbeck, R.H.

    1997-12-31

    This presentation discusses the origins of the present challenge faced in making mature oil fields profitable in the North Sea. It briefly examines the origins of these challenges, which are rooted in the industrial psychology of the North Sea. It develops a methodological formula for the successful re-engineering of inefficiently-run assets, focusing in particular on the personnel management aspects. It identifies some key areas to seek sustainable cost reductions and recognises the importance of renewing the context for investment in tail-end fields. Finally, it speculates about the way in which the learnings developed in the experiences of the last few years will influence the future of the North Sea. 2 refs.

  6. The upgraded Tevatron front end

    Glass, M.; Zagel, J.; Smith, P.; Marsh, W.; Smolucha, J.

    1990-01-01

    We are replacing the computers which support the CAMAC crates in the Fermilab accelerator control system. We want a significant performance increase, but we still want to be able to service scores of different varieties of CAMAC cards in a manner essentially transparent to console applications software. Our new architecture is based on symmetric multiprocessing. Several processors on the same bus, each running identical software, work simultaneously at satisfying different pieces of a console's request for data. We dynamically adjust the load between the processors. We can obtain more processing power by simply plugging in more processor cards and rebooting. We describe in this paper what we believe to be the interesting architectural features of the new front-end computers. We also note how we use some of the advanced features of the Multibus TM II bus and the Intel 80386 processor design to achieve reliability and expandability of both hardware and software. (orig.)

  7. Orbital maneuvering vehicle end effectors

    Myers, W. Neill (Inventor); Forbes, John C. (Inventor); Barnes, Wayne L. (Inventor)

    1988-01-01

    An end effector device (A) for grasping and holding an article such as a handle (18) of a space telescope is disclosed. The device includes a V-shaped capture window (74) defined as inclined surfaces (76, 78) in parallel face plates (22, 24) which converge toward a retainer recess (54) in which the handle is retained. A pivotal finger (30) meshes with a pair of pivoted fingers (26, 28) which rotate in counterrotation. The fingers rotate to pull a handle within the capture window into recess (54) where latches (50) lock handle (18) in the recess. To align the capture window, plates (22, 24) may be cocked plus or minus five degrees on base (64).

  8. The End of Eastern Territoriality?

    Vasev, Nikolay Rumenov; Vrangbæk, Karsten; Krepelka, Filip

    2017-01-01

    . For the results in the old Member States we rely on Obermaier’s 2009 “The End of Territoriality”. The study is qualitative in nature and relies mostly on qualitative semi-structured interviews with experts from ministries of health, health insurers and legal experts from all three countries. We distinguish...... and the European healthcare union’s strength in the new Members. In order to deliver a structured analysis and transferrable results, we compare Poland, the Czech Republic and Bulgaria with France and Germany. The countries are selected on the basis of the commonalities in their systems’ organization...... domestic conditions, ranging from insurance funds’ amenability, national courts’ complaisance and state administration’s obstinacy....

  9. User friendly far front ends

    Zagel, J.R.; Chapman, L.J.

    1987-10-01

    For years controls group hardware designers have designed microprocessor systems to accomplish specific functions such as refrigeration control. These systems often require years of software effort. The backlog of requests for even simple additions or modifications to software in embedded controllers has become overwhelming. We discuss the requirements of ''far forward'' controllers. Can we build a system that is modular enough to be configurable for specific applications without sacrificing performance? The hardware and software framework must be complete enough to isolate the end user from the peculiarities of bit and byte manipulation, but still allow system specifics to be implanted by the user. It is time to provide embedded controller systems as easy to use as workstation consoles

  10. Shallow End Response from ATEM

    Vetrov, A.

    2014-12-01

    Different geological, hydrological, environmental and engineering targets are located shallow underground. The information collected with ATEM systems might be very useful for their study; although there are many deeper targets that the ATEM systems are traditionally used for. The idea to raise magnetic moment output and get deeper penetration response was one of the goals of ATEM systems development during the last decade. The shallow geology response was a trade for such systems, which sometimes were almost blind in the first hundred meter under surface. The possibility to achieve shallow end response from ATEM systems has become significant subject in last years. Several airborne TDEM systems got second higher frequency and lower magnetic moment signal to pick up shallow response together with deep one. Having a potential advantage such implementation raises complication and cost of the system. There's no need to receive 500 meter deep response when exploring shallow geology. P-THEM system having a compact size transmitter and relatively light weight is working on one base frequency at a time, but this frequency can be preset before a flight considering survey goals. A study of shallow geology response of the P-THEM system working on different base frequency has been conducted in 2014 in Ontario. The Alliston test area located in Southern Ontario has been flown with the P-THEM system working on base frequencies 30Hz and 90Hz. Results of the observations will be discussed in the presentation. The shallow end data can be used for mineral exploration applications and also for hydrological and environmental studies.

  11. End design of the SSC 58 mm High Gradient Quadrupole

    Caspi, S.

    1992-01-01

    The ''end'' design of the High Gradient Quad. was done with consideration to the integrated field harmonics, the iron contribution, and the maximum field at the conductor. Magnetic analysis was done on the return end only, however the physical dimension of the lead end were determined as well. Using the cross-section of the windings and Cook's program BEND, we generated the physical end windings around the return end. Placing a single wire at the center of each turn the integrated gradient was computed and iterating on the end block spacers the integrated harmonics minimized. The final geometry was then used for more, extensive calculations, such as the field at the conductor and the 3D field harmonics. For this detailed calculation we have placed a single line current at the center of each strand and included the iron contribution (μ = ∞), see Appendix C. With the termination of the iron serving as a reference, the maximum length of the inner and outer layers are 182 mm and 215 mm respectively. The magnetic length of the end was computed from the gradient function A 2 and was found to be 142 mm. In reality we expect the physical length of the end to be somewhat larger, however this should have little or no effect on the magnetic length. The gradient in the straight section is 212.44 T/m at 7000 A and the integrated value of the gradient is -3.01665 E5 (G) in the end region marked by the magnetic length of the end. The respective integrated harmonics for the end 12 pole and 20 pole are -10.6658 (G/CM 4 ) and 0.7279 (G/cm 8 ) corresponding to b 6 = 0.351 , b 10 = -0.024 units. The above was computed from the values of A 2 , A 6 , and A 10

  12. Modeling and simulation of satellite subsystems for end-to-end spacecraft modeling

    Schum, William K.; Doolittle, Christina M.; Boyarko, George A.

    2006-05-01

    During the past ten years, the Air Force Research Laboratory (AFRL) has been simultaneously developing high-fidelity spacecraft payload models as well as a robust distributed simulation environment for modeling spacecraft subsystems. Much of this research has occurred in the Distributed Architecture Simulation Laboratory (DASL). AFRL developers working in the DASL have effectively combined satellite power, attitude pointing, and communication link analysis subsystem models with robust satellite sensor models to create a first-order end-to-end satellite simulation capability. The merging of these two simulation areas has advanced the field of spacecraft simulation, design, and analysis, and enabled more in-depth mission and satellite utility analyses. A core capability of the DASL is the support of a variety of modeling and analysis efforts, ranging from physics and engineering-level modeling to mission and campaign-level analysis. The flexibility and agility of this simulation architecture will be used to support space mission analysis, military utility analysis, and various integrated exercises with other military and space organizations via direct integration, or through DOD standards such as Distributed Interaction Simulation. This paper discusses the results and lessons learned in modeling satellite communication link analysis, power, and attitude control subsystems for an end-to-end satellite simulation. It also discusses how these spacecraft subsystem simulations feed into and support military utility and space mission analyses.

  13. Nerve endings in the heart of teleosts.

    Kumar, S

    1979-01-01

    The nerve endings in the heart of fishes were studied using silver impregnation techniques. The heart chambers are profusely innervated by the sympathetic, parasympathetic (vagal) and postganglionic fibers of the intracardiac ganglia situated at the sinuatrial and the atrioventricular junctions. The plexuses are composed of medullated and nonmedullated fibers. The nerve fibers generally end freely and are slightly branched or unbranched terminations of myelinated and unmyelinated fibers. Moreover, a few nerve fibers end redundant in the form of end-rings, bulb-like, bush-like, club-shaped end end-coil like structures. The complex unencapsulated types of endings are also found in the myocardium of the atrium and the ventricle. The encapsulated endings (Vater-Pacinian; Krause end-bulb) could not be observed.

  14. SSC collider dipole magnet end mechanical design

    Delchamps, S.W.; Bossert, R.C.; Carson, J.; Ewald, K.; Fulton, H.; Kerby, J.; Koska, W.; Strait, J.; Wake, S.M.; Leung, K.K.

    1991-05-01

    This paper describes the mechanical design of the ends of Superconducting Super Collider dipole magnets to be constructed and tested at Fermilab. Coil end clamps, end yoke configuration, and end plate design are discussed. Loading of the end plate by axial Lorentz forces is discussed. Relevant data from 40 mm and 50 mm aperture model dipole magnets built and tested at Fermilab are presented. In particular, the apparent influence of end clamp design on the quench behavior of model SSC dipoles is described. 8 refs., 3 figs

  15. ROBOTIC TANK INSPECTION END EFFECTOR

    Rachel Landry

    1999-01-01

    The objective of this contract between Oceaneering Space Systems (OSS) and the Department of Energy (DOE) was to provide a tool for the DOE to inspect the inside tank walls of underground radioactive waste storage tanks in their tank farms. Some of these tanks are suspected to have leaks, but the harsh nature of the environment within the tanks precludes human inspection of tank walls. As a result of these conditions only a few inspection methods can fulfill this task. Of the methods available, OSS chose to pursue Alternating Current Field Measurement (ACFM), because it does not require clean surfaces for inspection, nor any contact with the Surface being inspected, and introduces no extra by-products in the inspection process (no coupling fluids or residues are left behind). The tool produced by OSS is the Robotic Tank Inspection End Effector (RTIEE), which is initially deployed on the tip of the Light Duty Utility Arm (LDUA). The RTEE combines ACFM with a color video camera for both electromagnetic and visual inspection The complete package consists of an end effector, its corresponding electronics and software, and a user's manual to guide the operator through an inspection. The system has both coarse and fine inspection modes and allows the user to catalog defects and suspected areas of leakage in a database for further examination, which may lead to emptying the tank for repair, decommissioning, etc.. The following is an updated report to OSS document OSS-21100-7002, which was submitted in 1995. During the course of the contract, two related sub-tasks arose, the Wall and Coating Thickness Sensor and the Vacuum Scarifying and Sampling Tool Assembly. The first of these sub-tasks was intended to evaluate the corrosion and wall thinning of 55-gallon steel drums. The second was retrieved and characterized the waste material trapped inside the annulus region of the underground tanks on the DOE's tank farms. While these sub-tasks were derived from the original intent

  16. The End of a Century, the End of an Era

    Miguel Ángel Vecino

    2000-12-01

    Full Text Available Ten years after the end of bipolarity, expectations that arose at first have gone unfulfilled. The lack of a conceptual framework that would allow objective analysis of the present situation has made an already confusing situation worse. Attempts to describe the future have in most cases been nothing more than statements of what is already past. Some writers have tried to propose thought structures that would help cut through the international haze we live in, but in most cases, they have, unfortunately, in most cases been overwhelmed by the hegemonic force of the one way of thinking based on a systematic, a priori dismissal of anything that does not give its blessing to the new world based on the purely economic criteria of globalization. Because of the unpredictability of the collapse of the old bipolar scheme, projects belonging to the past have gone on being implemented, one notable example being the euro. The issue is not the distribution of wealth but rather one of the concentration of wealth with the number of poor people in the world increasing while the world’s great powers fight to reestablish their independence in foreign policy in face of the of the predominant role of the United States. International organizations, foremost among them the UN, are being supplanted by other more or less informal venues (such as the G-8 where the world’s future is decided on the basis of economic power while the reality of a world population ever more divided into asmall nucleus of rich people and an ever greater number of poor people is ignored.

  17. Applying the means-end chain concept to product development

    Søndergaard, Helle Alsted

    This paper proposes that the means-end chain (MEC) approach can influence the use of market information and inter-functional communication in new product development (NPD). The central question is whether market information represented by means-end chain data can be a vehicle for inter......-functional communication. This paper describes a PhD project - that through case studies and action research in two companies - aims at investigating the effects on communication and attitudes to communication by those involved when introducing means-end chain data as market information in NPD....

  18. End-to-end models for marine ecosystems: Are we on the precipice of a significant advance or just putting lipstick on a pig?

    Kenneth A. Rose

    2012-02-01

    Full Text Available There has been a rapid rise in the development of end-to-end models for marine ecosystems over the past decade. Some reasons for this rise include need for predicting effects of climate change on biota and dissatisfaction with existing models. While the benefits of a well-implemented end-to-end model are straightforward, there are many challenges. In the short term, my view is that the major role of end-to-end models is to push the modelling community forward, and to identify critical data so that these data can be collected now and thus be available for the next generation of end-to-end models. I think we should emulate physicists and build theoretically-oriented models first, and then collect the data. In the long-term, end-to-end models will increase their skill, data collection will catch up, and end-to-end models will move towards site-specific applications with forecasting and management capabilities. One pathway into the future is individual efforts, over-promise, and repackaging of poorly performing component submodels (“lipstick on a pig”. The other pathway is a community-based collaborative effort, with appropriate caution and thoughtfulness, so that the needed improvements are achieved (“significant advance”. The promise of end-to-end modelling is great. We should act now to avoid missing a great opportunity.

  19. Key role of social work in effective communication and conflict resolution process: Medical Orders for Life-Sustaining Treatment (MOLST) Program in New York and shared medical decision making at the end of life.

    Bomba, Patricia A; Morrissey, Mary Beth; Leven, David C

    2011-01-01

    In this article, the authors review the development of the Medical Orders for Life-Sustaining Treatment (MOLST) Program and recent landmark legislation in New York State in the context of advance care planning and shared medical decision making at the end of life. Social workers are central health care professionals in working with patients, families, practitioners, health care agents, and surrogates in the health systems and in the communication and conflict resolution process that is integral to health care decision making. The critical importance of ethics and end-of-life training and education for social workers is also addressed. Data from a pilot study evaluating interdisciplinary ethics training on legal and ethical content in communication and conflict resolution skills in health care decision making are reported. Recommendations are made for research on education and training of social workers, and investigation of the role and influence of systems in shaping social work involvement in end-of-life and palliative care.

  20. Biomass Resource Allocation among Competing End Uses

    Newes, E.; Bush, B.; Inman, D.; Lin, Y.; Mai, T.; Martinez, A.; Mulcahy, D.; Short, W.; Simpkins, T.; Uriarte, C.; Peck, C.

    2012-05-01

    The Biomass Scenario Model (BSM) is a system dynamics model developed by the U.S. Department of Energy as a tool to better understand the interaction of complex policies and their potential effects on the biofuels industry in the United States. However, it does not currently have the capability to account for allocation of biomass resources among the various end uses, which limits its utilization in analysis of policies that target biomass uses outside the biofuels industry. This report provides a more holistic understanding of the dynamics surrounding the allocation of biomass among uses that include traditional use, wood pellet exports, bio-based products and bioproducts, biopower, and biofuels by (1) highlighting the methods used in existing models' treatments of competition for biomass resources; (2) identifying coverage and gaps in industry data regarding the competing end uses; and (3) exploring options for developing models of biomass allocation that could be integrated with the BSM to actively exchange and incorporate relevant information.

  1. The Open-Ended Approach Framework

    Munroe, Lloyd

    2015-01-01

    This paper describes a pedagogical framework that teachers can use to support students who are engaged in solving open-ended problems, by explaining how two Japanese expert teachers successfully apply open-ended problems in their mathematics class. The Open-Ended Approach (OPA) framework consists of two main sections: Understanding Mathematical…

  2. 7 CFR 51.1240 - Paper ends.

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Paper ends. 51.1240 Section 51.1240 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Standards for Cleaned Virginia Type Peanuts in the Shell Definitions § 51.1240 Paper ends. Paper ends means...

  3. End-to-End Assessment of a Large Aperture Segmented Ultraviolet Optical Infrared (UVOIR) Telescope Architecture

    Feinberg, Lee; Rioux, Norman; Bolcar, Matthew; Liu, Alice; Guyon, Oliver; Stark, Chris; Arenberg, Jon

    2016-01-01

    Key challenges of a future large aperture, segmented Ultraviolet Optical Infrared (UVOIR) Telescope capable of performing a spectroscopic survey of hundreds of Exoplanets will be sufficient stability to achieve 10^-10 contrast measurements and sufficient throughput and sensitivity for high yield Exo-Earth spectroscopic detection. Our team has collectively assessed an optimized end to end architecture including a high throughput coronagraph capable of working with a segmented telescope, a cost-effective and heritage based stable segmented telescope, a control architecture that minimizes the amount of new technologies, and an Exo-Earth yield assessment to evaluate potential performance. These efforts are combined through integrated modeling, coronagraph evaluations, and Exo-Earth yield calculations to assess the potential performance of the selected architecture. In addition, we discusses the scalability of this architecture to larger apertures and the technological tall poles to enabling it.

  4. End-to-end operations at the National Radio Astronomy Observatory

    Radziwill, Nicole M.

    2008-07-01

    In 2006 NRAO launched a formal organization, the Office of End to End Operations (OEO), to broaden access to its instruments (VLA/EVLA, VLBA, GBT and ALMA) in the most cost-effective ways possible. The VLA, VLBA and GBT are mature instruments, and the EVLA and ALMA are currently under construction, which presents unique challenges for integrating software across the Observatory. This article 1) provides a survey of the new developments over the past year, and those planned for the next year, 2) describes the business model used to deliver many of these services, and 3) discusses the management models being applied to ensure continuous innovation in operations, while preserving the flexibility and autonomy of telescope software development groups.

  5. SPD very front end electronics

    Luengo, S.; Gascon, D.; Comerma, A.; Garrido, L.; Riera, J.; Tortella, S.; Vilasis, X.

    2006-01-01

    The Scintillator Pad Detector (SPD) is part of the LHCb calorimetry system [D. Breton, The front-end electronics for LHCb calorimeters, Tenth International Conference on Calorimetry in Particle Physics, CALOR, Pasadena, 2002] that provides high-energy hadron, electron and photon candidates for the first level trigger. The SPD is designed to distinguish electrons from photons. It consists of a plastic scintillator layer, divided into about 6000 cells of different size to obtain better granularity near the beam [S. Amato, et al., LHCb technical design report, CERN/LHCC/2000-0036, 2000]. Charged particles will produce, and photons will not, ionization in the scintillator. This ionization generates a light pulse that is collected by a WaveLength Shifting (WLS) fiber that is coiled inside the scintillator cell. The light is transmitted through a clear fiber to the readout system that is placed at the periphery of the detector. Due to space constraints, and in order to reduce costs, these 6000 cells are divided in groups using a MAPMT [Z. Ajaltouni, et al., Nucl. Instr. and Meth. A 504 (2003) 9] of 64 channels that provides information to the VFE readout electronics. The SPD signal has rather large statistical fluctuations because of the low number (20-30) of photoelectrons per MIP. Therefore the signal is integrated over the whole bunch crossing length of 25 ns in order to have the maximum value. Since in average about 85% of the SPD signal is within 25 ns, 15% of a sample is subtracted from the following one using an operational amplifier. The SPD VFE readout system that will be presented consists of the following components. A specific ASIC [D. Gascon, et al., Discriminator ASIC for the VFE SPD of the LHCb Calorimeter, LHCB Technical Note, LHCB 2004-xx] integrates the signal, makes the signal-tail subtraction, and compares the level obtained to a programmable threshold (to distinguish electrons from photons). A FPGA programmes the ASIC threshold and the value for

  6. AN ANALYSIS OF THE APPLICATION END TO END QUALITY OF SERVICE ON 3G TELECOMMUNICATION NETWORK

    Cahya Lukito

    2012-05-01

    Full Text Available End to End Quality of Service is a way to provide data package service in a telecommunication network that based on Right Price, Right Service Level, and Right Quality. The goal of this research is to analyze the impact of End to End QoS use on 3G telecommunication network for voice service and data. This research uses an analysis method by doing the application on the lab. The result that is achieved in this research shows that End to End QoS is very influental to the Service Level Agreement to the users of the telecommunication service.Keywords: End to End Qos, SLA, Diffserv

  7. Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats

    Vaněčková, Ivana; Kujal, P.; Husková, Z.; Vaňourková, Z.; Vernerová, Z.; Čertíková; Chábová, V.; Škaroupková, P.; Kramer, H. J.; Tesař, V.; Červenka, L.

    2012-01-01

    Roč. 35, č. 5 (2012), s. 382-392 ISSN 1420-4096 Institutional research plan: CEZ:AV0Z50110509 Keywords : 5/6 nephrectomy * Endothelin receptor type A * AT1 receptor blocker * end-organ damage * hypertension Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 1.596, year: 2012

  8. An alternate end design for SSC dipoles

    Peters, C.; Caspi, S.; Taylor, C.

    1989-02-01

    Experience in the SSC dipole program has shown that fabrication of cylindrical coil ends is difficult. Cable stiffness requires large forces to maintain the proper position of the conductors in the end during winding. After winding, the coil ends remain distorted nd significant motion of the need conductors is required to force the coil end into the molding cavity. Local mechanical stresses are high during this process and extra pieces of insulation are required to prevent turn-to-turn shorts from developing during the winding and molding steps. Prior to assembly the coil end is compressed in a mold cavity and injected with a filler material to correct surface irregularities and fill voids in the end. LBL has developed an alternate design which permits the conductors to be wound over the end using minimal force and technician coerosion. The conductors are placed on a conical surface where the largest diameter over the outer layer conductors is 10 cm. No coil end spaces or insulation pieces between turns are required. The conductor geometry was analytically optimized to meet SSC multipole requirements for the ends. The first 1-m dipole utilizing this end geometry has been constructed and successfully tested. Design and construction data are presented. Also model test results, including training and multipole measurements of the end are given. 1 ref., 12 figs., 3 tabs

  9. Reluctance to change and end psychotherapy

    John E. Berg

    2018-01-01

    Full Text Available Reluctance to change therapy has clinical and economic implications. Therapists are expected to deliver treatment in a oneto- one setting ending up with patient improvement. Such an achievement is difficult to overview. There is great uncertainty as to what works in psychotherapies despite research efforts. Prolonged treatment duration with little positive effect may be caused by factors inherent in therapist and patient and the external environment. Two cases are discussed illustrating the need for better surveillance of what happens in the therapy room. Responsibility for the progress in therapy rests on the shoulders of the therapist. When therapy becomes detrimental to patient and therapist, we do not have a comprehensive system to interfere or help. Delayed recovery emanates as an increase in costs to society and the family. This is the case when return to work after treatment is partly or completely retarded.

  10. End-Triassic nonmarine biotic events

    Spencer G. Lucas

    2015-10-01

    Full Text Available The Late Triassic was a prolonged interval of elevated extinction rates and low origination rates that manifested themselves in a series of extinctions during Carnian, Norian and Rhaetian time. Most of these extinctions took place in the marine realm, particularly affecting radiolarians, conodonts, bivalves, ammonoids and reef-building organisms. On land, the case for a Late Triassic mass extinction is much more tenuous and has largely focused on tetrapod vertebrates (amphibians and reptiles, though some workers advocate a sudden end-Triassic (TJB extinction of land plants. Nevertheless, an extensive literature does not identify a major extinction of land plants at the TJB, and a comprehensive review of palynological records concluded that TJB vegetation changes were non-uniform (different changes in different places, not synchronous and not indicative of a mass extinction of land plants. Claims of a substantial perturbation of plant ecology and diversity at the TJB in East Greenland are indicative of a local change in the paleoflora largely driven by lithofacies changes resulting in changing taphonomic filters. Plant extinctions at the TJB were palaeogeographically localized events, not global in extent. With new and more detailed stratigraphic data, the perceived TJB tetrapod extinction is mostly an artifact of coarse temporal resolution, the compiled correlation effect. The amphibian, archosaur and synapsid extinctions of the Late Triassic are not concentrated at the TJB, but instead occur stepwise, beginning in the Norian and extending into the Hettangian. There was a disruption of the terrestrial ecosystem across the TJB, but it was more modest than generally claimed. The ecological severity of the end-Triassic nonmarine biotic events are relatively low on the global scale. Biotic turnover at the end of the Triassic was likely driven by the CAMP (Central Atlantic Magmatic Province eruptions, which caused significant environmental

  11. Let's End the Grading Game.

    Edwards, Clifford H.; Edwards, Laurie

    1999-01-01

    Argues that grades have negative effects on learning and self-concept. States that while grading has a long tradition of sorting children for college entrance, there is limited evidence that grades serve a valid purpose. Argues that this practice should be abolished and an evaluation system established that provides a more valid estimate of…

  12. Impacts of the Deepwater Horizon oil spill evaluated using an end-to-end ecosystem model.

    Ainsworth, Cameron H; Paris, Claire B; Perlin, Natalie; Dornberger, Lindsey N; Patterson, William F; Chancellor, Emily; Murawski, Steve; Hollander, David; Daly, Kendra; Romero, Isabel C; Coleman, Felicia; Perryman, Holly

    2018-01-01

    We use a spatially explicit biogeochemical end-to-end ecosystem model, Atlantis, to simulate impacts from the Deepwater Horizon oil spill and subsequent recovery of fish guilds. Dose-response relationships with expected oil concentrations were utilized to estimate the impact on fish growth and mortality rates. We also examine the effects of fisheries closures and impacts on recruitment. We validate predictions of the model by comparing population trends and age structure before and after the oil spill with fisheries independent data. The model suggests that recruitment effects and fishery closures had little influence on biomass dynamics. However, at the assumed level of oil concentrations and toxicity, impacts on fish mortality and growth rates were large and commensurate with observations. Sensitivity analysis suggests the biomass of large reef fish decreased by 25% to 50% in areas most affected by the spill, and biomass of large demersal fish decreased even more, by 40% to 70%. Impacts on reef and demersal forage caused starvation mortality in predators and increased reliance on pelagic forage. Impacts on the food web translated effects of the spill far away from the oiled area. Effects on age structure suggest possible delayed impacts on fishery yields. Recovery of high-turnover populations generally is predicted to occur within 10 years, but some slower-growing populations may take 30+ years to fully recover.

  13. Surrogate end points in clinical research: hazardous to your health.

    Grimes, David A; Schulz, Kenneth F

    2005-05-01

    Surrogate end points in clinical research pose real danger. A surrogate end point is an outcome measure, commonly a laboratory test, that substitutes for a clinical event of true importance. Resistance to activated protein C, for example, has been used as a surrogate for venous thrombosis in women using oral contraceptives. Other examples of inappropriate surrogate end points in contraception include the postcoital test instead of pregnancy to evaluate new spermicides, breakage and slippage instead of pregnancy to evaluate condoms, and bone mineral density instead of fracture to assess the safety of depo-medroxyprogesterone acetate. None of these markers captures the effect of the treatment on the true outcome. A valid surrogate end point must both correlate with and accurately predict the outcome of interest. Although many surrogate markers correlate with an outcome, few have been shown to capture the effect of a treatment (for example, oral contraceptives) on the outcome (venous thrombosis). As a result, thousands of useless and misleading reports on surrogate end points litter the medical literature. New drugs have been shown to benefit a surrogate marker, but, paradoxically, triple the risk of death. Thousands of patients have died needlessly because of reliance on invalid surrogate markers. Researchers should avoid surrogate end points unless they have been validated; that requires at least one well done trial using both the surrogate and true outcome. The clinical maxim that "a difference to be a difference must make a difference" applies to research as well. Clinical research should focus on outcomes that matter.

  14. Electronic Nicotine Delivery Systems (ENDS): What Nurses Need to Know.

    Essenmacher, Carol; Naegle, Madeline; Baird, Carolyn; Vest, Bridgette; Spielmann, Rene; Smith-East, Marie; Powers, Leigh

    Efforts to decrease adverse effects of tobacco use are affected by emergence of new nicotine delivery products. Advertising, product promotion, and social media promote use of these products, yet a lack of evidence regarding safety leaves nurses unprepared to counsel patients. To critically evaluate current research, reviews of literature, expert opinion, and stakeholder policy proposals on use and safety of electronic nicotine delivery systems (ENDS). A targeted examination of literature generated by key stakeholders and subject matter experts was conducted using key words, modified by risk factors, and limited to the past 8 years. Current knowledge gaps in research literature and practice implications of the literature are discussed. The safety of ENDS is questionable and unclear. There are clear health risks of nicotine exposure to developing brains. Potential health risks of ENDS secondhand emissions exposure exist. Using ENDS to facilitate total tobacco cessation is not proven.

  15. Effects of medical therapy, alcohol, smoking, and endocrine disruptors on male infertility Efeitos da terapia medicamentosa, àlcool, cigarros e substância deletérias para o sistema endócrino na infertilidade masculina

    Fábio Firmbach Pasqualotto

    2004-01-01

    Full Text Available Infertility affects up to 15% of the sexually active population, and in 50% of cases, a male factor is involved, either as a primary problem or in combination with a problem in the female partner. Because many commonly encountered drugs and medications can have a detrimental effect on male fertility, the medical evaluation should include a discussion regarding the use of recreational and illicit drugs, medications, and other substances that may impair fertility. With the knowledge of which drugs and medications may be detrimental to fertility, it may be possible to modify medication regimens or convince a patient to modify habits to decrease adverse effects on fertility and improve the chances of achieving a successful pregnancy. Concern is growing that male sexual development and reproduction have changed for the worse over the past 30 to 50 years. Although some reports find no changes, others suggest that sperm counts appear to be decreasing and that the incidence of developmental abnormalities such as hypospadias and cryptorchidism appears to be increasing, as is the incidence of testicular cancer. These concerns center around the possibility that our environment is contaminated with chemicals - both natural and synthetic - that can interact with the endocrine system.A infertilidade afeta até 15% da população sexualmente ativa e em 50% dos casos, o fator masculino está envolvido, como problema primário ou em combinação com causas de origem feminina. Como muitas drogas comumente encontradas e medicações podem ter efeitos deletérios na infertilidade masculina, a avaliação médica deve incluir uma discussão sobre o uso de drogas recreacionais e ilícitas, medicamentos e outras substâncias podem prejudicar a fertilidade. Com o conhecimento de quais drogas e medicamentos podem ser prejudiciais à fertilidade talvez seja possível mudar os hábitos ou a posologia das medicações para diminuir os efeitos adversos na fertilidade e

  16. Kinetic approach to plasma end loss from linear devices

    Dreicer, H.

    1976-01-01

    A first step in the direction of a kinetic approach to end loss has been presented. This approach brings to light some fundamental processes not uncovered by the magnetohydrodynamic or guiding center approach. Attention was focused on the basically transient phenomenon in a way that describes the quite different behavior of collision dominated and collisionless ions, but ignores the magnetic nozzle effects near the ends of the system. The treatment illuminates some of the roles played by the parameter l/sub ii//L, and suggests the direction for more detailed investigations. End loss from linear systems is a very many faceted problem. Kinetic effects, magnetic effects, heat flow, etc. are all intermixed, and it will require a strong long term experimental and theoretical program to unravel all of its mysteries

  17. [End therapeutic nihilism towards COPD].

    Juergens, Uwe R

    2007-03-15

    Prevention of COPD requires appropriate patient education, especially of adolescents, as well as the establishment of an effective national health policy. The new GOLD guidelines represent the current standard of knowledge on the management of chronic, progressive, obstructive pulmonary diseases. It points out that COPD is avoidable and treatable,and hence, there is no reason for therapeutic nihilism. Chronic bronchitis preceding a progressive respiratory obstruction cannot be improved with the presently available respiratory therapeutics. For this reason, therapeutic measures concentrate on the avoidance of exacerbations, which are primarily responsible for the severity of the course of COPD.

  18. Home-end and activity-end preferences for access to and egress from train stations in the Copenhagen region

    Halldórsdóttir, Katrín; Nielsen, Otto Anker; Prato, Carlo Giacomo

    2017-01-01

    . Moreover, model results emphasize the role of bicycle parking in terms of the sheer number of spaces to be increased as well as covered places to be offered at the activity end, de facto giving the possibility to leave a bicycle at that end during the night. Lastly, model results show that it is a matter......Increasing public transport use with the aim of improving the sustainability of cities should focus not only on enhancing level and quality of the service offered, but also on understanding determinants of the choice of access and egress modes to and from the railway network. This study analyzes...... the difference in preferences at the home-end and activity-end for travelers who have chosen train as their main travel mode while investigating the effect of policy variables such as car parking availability, bicycle parking availability and type, and bicycle on train possibility. Specifically, this study...

  19. End-to-end experiment management in HPC

    Bent, John M [Los Alamos National Laboratory; Kroiss, Ryan R [Los Alamos National Laboratory; Torrez, Alfred [Los Alamos National Laboratory; Wingate, Meghan [Los Alamos National Laboratory

    2010-01-01

    Experiment management in any domain is challenging. There is a perpetual feedback loop cycling through planning, execution, measurement, and analysis. The lifetime of a particular experiment can be limited to a single cycle although many require myriad more cycles before definite results can be obtained. Within each cycle, a large number of subexperiments may be executed in order to measure the effects of one or more independent variables. Experiment management in high performance computing (HPC) follows this general pattern but also has three unique characteristics. One, computational science applications running on large supercomputers must deal with frequent platform failures which can interrupt, perturb, or terminate running experiments. Two, these applications typically integrate in parallel using MPI as their communication medium. Three, there is typically a scheduling system (e.g. Condor, Moab, SGE, etc.) acting as a gate-keeper for the HPC resources. In this paper, we introduce LANL Experiment Management (LEM), an experimental management framework simplifying all four phases of experiment management. LEM simplifies experiment planning by allowing the user to describe their experimental goals without having to fully construct the individual parameters for each task. To simplify execution, LEM dispatches the subexperiments itself thereby freeing the user from remembering the often arcane methods for interacting with the various scheduling systems. LEM provides transducers for experiments that automatically measure and record important information about each subexperiment; these transducers can easily be extended to collect additional measurements specific to each experiment. Finally, experiment analysis is simplified by providing a general database visualization framework that allows users to quickly and easily interact with their measured data.

  20. Effect of Six Missile-Bay Baffle Configurations and a Rocket End Plate on Ejection Releases of an MB-1 Rocket from a 0.05 Scale Model of the Convair F-106A Airplane

    Hinson, William F.; Lee, John B.

    1959-01-01

    As a continuation of an investigation of the release characteristics of an MB-1 rocket carried internally by the Convair F-106A airplane, six missile-bay baffle configurations and a rocket end plate have been investigated in the 27- by 27-inch preflight jet of the NASA Wallops Station. The MB-1 rocket used had retractable fins and was ejected from a missile bay modified by the addition of six different baffle configurations. For some tests a rocket end plate was added to the model. Dynamically scaled models (0.04956 scale) were tested at a simulated altitude of 22,450 feet and Mach numbers of 0.86, 1.59, and 1.98, and at a simulated altitude of 29,450 feet and a Mach number of 1.98. The results of this investigation indicate that the missile-bay baffle configurations and the rocket end plate may be used to reduce the positive pitch amplitude of the MB-1 rocket after release. The initial negative pitching velocity applied to the MB-1 rocket might then be reduced in order to maintain a near-level-flight attitude after release. As the fuselage angle of attack is increased, the negative pitch amplitude of the rocket is decreased.

  1. Devoluming and stabilizing method for end piece

    Ikeda, Satoshi; Shiotsuki, Msao; Kawamura, Shigeyoshi; Komatsu, Fumiaki.

    1991-01-01

    As a first method, end pieces and other radioactive metal wastes are filled as a mixture in a vessel, and preliminary compression is conducted. Then, the bulk density of the radioactive metal wastes is reduced and gaps in the end pieces are filled with radioactive metal wastes. If they are applied with heat treatment under high pressure in this state together with the vessel, they are devolumed and stabilized without damaging the vessel. As a second method, metal powders are mixed and filled in the vessel together with the end pieces. The gaps in the end pieces are filled with the metal powders and if they are applied with heat treatment under high pressure in this state together with the vessel, the end pieces are devolumed and stabilized without damaging the vessel in the same manner. This can devolume and stabilize the end pieces separated from nuclear fuel assemblies easily and safely. (T.M.)

  2. The nerve endings of the acetabular labrum.

    Kim, Y T; Azuma, H

    1995-11-01

    The nerve endings of the human acetabular labrum were investigated. Twenty-three acetabular labra were obtained from 24 fresh human cadavers, stained with Suzuki's silver impregnation and an immunohistochemical technique for neurogenic specific protein S-100, and examined by light and electron microscopy. Ramified free nerve endings were seen in all specimens by silver staining, and also were observed by the immunohistochemical technique for S-100 protein. Sensory nerve end organs, such as a Vater-Pacini corpuscle, Golgi-Mazzoni corpuscle, Ruffini corpuscle, and articular corpuscle (Krause corpuscle), were observed by silver staining. Collagen fibers were scattered sparsely in the superficial layer of the labrum, and nerve endings were observed mostly in this region. Collagen fibers were sparse, and nerve endings also were observed in some regions among the collagen fiber bundles in the inner layer. Innervation of the acetabular labrum was confirmed in this study, suggesting that nerve endings in the labrum may be involved in nociceptive and proprioceptive mechanisms.

  3. Experimental demonstration of software defined data center optical networks with Tbps end-to-end tunability

    Zhao, Yongli; Zhang, Jie; Ji, Yuefeng; Li, Hui; Wang, Huitao; Ge, Chao

    2015-10-01

    The end-to-end tunability is important to provision elastic channel for the burst traffic of data center optical networks. Then, how to complete the end-to-end tunability based on elastic optical networks? Software defined networking (SDN) based end-to-end tunability solution is proposed for software defined data center optical networks, and the protocol extension and implementation procedure are designed accordingly. For the first time, the flexible grid all optical networks with Tbps end-to-end tunable transport and switch system have been online demonstrated for data center interconnection, which are controlled by OpenDayLight (ODL) based controller. The performance of the end-to-end tunable transport and switch system has been evaluated with wavelength number tuning, bit rate tuning, and transmit power tuning procedure.

  4. ATLAS electromagnetic end-cap detector

    Maximilien Brice

    2003-01-01

    After the insertion of the first end-cap into this cryostat, the team proceed to the wiring operations. Millions of wires are connected to the electromagnetic calorimeter on this end-cap, whch must be carefully fed out from the detector so that data can be read out. The energy of photons, electrons and positrons will be measured as they pass through the end-cap having been created along the line of the beams in the proton-proton collisions.

  5. Muon front end for the neutrino factory

    C. T. Rogers

    2013-04-01

    Full Text Available In the neutrino factory, muons are produced by firing high-energy protons onto a target to produce pions. The pions decay to muons and pass through a capture channel known as the muon front end, before acceleration to 12.6 GeV. The muon front end comprises a variable frequency rf system for longitudinal capture and an ionization cooling channel. In this paper we detail recent improvements in the design of the muon front end.

  6. Muon front end for the neutrino factory

    Rogers, C T; Prior, G; Gilardoni, S; Neuffer, D; Snopok, P; Alekou, A; Pasternak, J

    2013-01-01

    In the neutrino factory, muons are produced by firing high-energy protons onto a target to produce pions. The pions decay to muons and pass through a capture channel known as the muon front end, before acceleration to 12.6 GeV. The muon front end comprises a variable frequency rf system for longitudinal capture and an ionization cooling channel. In this paper we detail recent improvements in the design of the muon front end.

  7. Both movement-end and task-end are critical for error feedback in visuomotor adaptation: a behavioral experiment.

    Takumi Ishikawa

    Full Text Available An important issue in motor learning/adaptation research is how the brain accepts the error information necessary for maintaining and improving task performance in a changing environment. The present study focuses on the effect of timing of error feedback. Previous research has demonstrated that adaptation to displacement of the visual field by prisms in a manual reaching task is significantly slowed by delayed visual feedback of the endpoint, suggesting that error feedback is most effective when given at the end of a movement. To further elucidate the brain mechanism by which error information is accepted in visuomotor adaptation, we tested whether error acceptance is linked to the end of a given task or to the end of an executed movement. We conducted a behavioral experiment using a virtual shooting task in which subjects controlled their wrist movements to meet a target with a cursor as accurately as possible. We manipulated the timing of visual feedback of the impact position so that it occurred either ahead of or behind the true time of impact. In another condition, the impact timing was explicitly indicated by an additional cue. The magnitude of the aftereffect significantly varied depending on the timing of feedback (p < 0.05, Friedman's Test. Interestingly, two distinct peaks of aftereffect were observed around movement-end and around task-end, irrespective of the existence of the timing cue. However, the peak around task-end was sharper when the timing cue was given. Our results demonstrate that the brain efficiently accepts error information at both movement-end and task-end, suggesting that two different learning mechanisms may underlie visuomotor transformation.

  8. End o' the line revisited

    De Mey, Jo G R; Vanhoutte, Paul M

    2014-01-01

    When endothelin-1(ET-1) was discovered it was hailed as the prototypical endothelium-derived contracting factor (EDCF). However, over the years little evidence emerged convincingly demonstrating that the peptide actually contributes to moment-to-moment changes in vascular tone elicited by endothe......When endothelin-1(ET-1) was discovered it was hailed as the prototypical endothelium-derived contracting factor (EDCF). However, over the years little evidence emerged convincingly demonstrating that the peptide actually contributes to moment-to-moment changes in vascular tone elicited...... of endothelial dysfunction when the NO bioavailability is considerably reduced if not absent. The present essay discusses whether or not this concept should be revised, in particular in view of the potent inhibitory effect exerted by calcitonin gene related peptide (CGRP) released from sensorimotor nerves...

  9. Nuclear fuel rod end plug weld inspection

    Parker, M. A.; Patrick, S. S.; Rice, G. F.

    1985-01-01

    Apparatus and method for testing TIG (tungsten inert gas) welds of end plugs on a sealed nuclear reactor fuel rod. An X-ray fluorescent spectrograph testing unit detects tungsten inclusion weld defects in the top end plug's seal weld. Separate ultrasonic weld inspection system testing units test the top end plug's seal and girth welds and test the bottom end plug's girth weld for penetration, porosity and wall thinning defects. The nuclear fuel rod is automatically moved into and out from each testing unit and is automatically transported between the testing units by rod handling devices. A controller supervises the operation of the testing units and the rod handling devices

  10. Analytical solutions to SSC coil end design

    Bossert, R.C.; Brandt, J.S.; Carson, J.A.; Fulton, H.J.; Lee, G.C.; Cook, J.M.

    1989-03-01

    As part of the SCC magnet effort, Fermilab will build and test a series of one meter model SSC magnets. The coils in these magnets will be constructed with several different end configurations. These end designs must satisfy both mechanical and magnetic criteria. Only the mechanical problem will be addressed. Solutions will attempt to minimize stresses and provide internal support for the cable. Different end designs will be compared in an attempt to determine which is most appropriate for the SSC dipole. The mathematics required to create each end configuration will be described. The computer aided design, programming and machine technology needed to make the parts will be reviewed. 2 refs., 10 figs

  11. Plugger guide for aligning an end plug and a fuel rod tube end

    Klapper, K.K.; Boatwright, D.A.

    1987-01-01

    A pin driving tool is described for inserting or removing pins from teeth on a digging means, comprising: fuel rod tube toward an end plug for application of the end plug into the tube end, the apparatus comprising: (a) a guide housing having an elongated central longitudinal bore with one end for receiving the end plug and an opposite end for receiving the fuel rod tube end; (b) sets of rolling elements disposed in the housing at axially spaced positions along and about the bore thereof. The rolling elements in each set are positioned in fixed relation with respect to one another to receive the fuel rod tube end therebetween and align the tube end with the end plug as the tube end is moved through the bore and into engagement with the end plug; and (c) retaining means disposed adjacent to the open end of the housing bore for engaging the end plug so as to maintain it in a stationary seated position at the one end of the housing bore

  12. Comparison of Direct Side-to-End and End-to-End Hypoglossal-Facial Anastomosis for Facial Nerve Repair.

    Samii, Madjid; Alimohamadi, Maysam; Khouzani, Reza Karimi; Rashid, Masoud Rafizadeh; Gerganov, Venelin

    2015-08-01

    The hypoglossal facial anastomosis (HFA) is the gold standard for facial reanimation in patients with severe facial nerve palsy. The major drawbacks of the classic HFA technique are lingual morbidities due to hypoglossal nerve transection. The side-to-end HFA is a modification of the classic technique with fewer tongue-related morbidities. In this study we compared the outcome of the classic end-to-end and the direct side-to-end HFA surgeries performed at our center in regards to the facial reanimation success rate and tongue-related morbidities. Twenty-six successive cases of HFA were enrolled. In 9 of them end-to-end anastomoses were performed, and 17 had direct side-to-end anastomoses. The House-Brackmann (HB) and Pitty and Tator (PT) scales were used to document surgical outcome. The hemiglossal atrophy, swallowing, and hypoglossal nerve function were assessed at follow-up. The original pathology was vestibular schwannoma in 15, meningioma in 4, brain stem glioma in 4, and other pathologies in 3. The mean interval between facial palsy and HFA was 18 months (range: 0-60). The median follow-up period was 20 months. The PT grade at follow-up was worse in patients with a longer interval from facial palsy and HFA (P value: 0.041). The lesion type was the only other factor that affected PT grade (the best results in vestibular schwannoma and the worst in the other pathologies group, P value: 0.038). The recovery period for facial tonicity was longer in patients with radiation therapy before HFA (13.5 vs. 8.5 months) and those with a longer than 2-year interval from facial palsy to HFA (13.5 vs. 8.5 months). Although no significant difference between the side-to-end and the end-to-end groups was seen in terms of facial nerve functional recovery, patients from the side-to-end group had a significantly lower rate of lingual morbidities (tongue hemiatrophy: 100% vs. 5.8%, swallowing difficulty: 55% vs. 11.7%, speech disorder 33% vs. 0%). With the side-to-end HFA

  13. Advanced Camera Image Cropping Approach for CNN-Based End-to-End Controls on Sustainable Computing

    Yunsick Sung

    2018-03-01

    Full Text Available Recent research on deep learning has been applied to a diversity of fields. In particular, numerous studies have been conducted on self-driving vehicles using end-to-end approaches based on images captured by a single camera. End-to-end controls learn the output vectors of output devices directly from the input vectors of available input devices. In other words, an end-to-end approach learns not by analyzing the meaning of input vectors, but by extracting optimal output vectors based on input vectors. Generally, when end-to-end control is applied to self-driving vehicles, the steering wheel and pedals are controlled autonomously by learning from the images captured by a camera. However, high-resolution images captured from a car cannot be directly used as inputs to Convolutional Neural Networks (CNNs owing to memory limitations; the image size needs to be efficiently reduced. Therefore, it is necessary to extract features from captured images automatically and to generate input images by merging the parts of the images that contain the extracted features. This paper proposes a learning method for end-to-end control that generates input images for CNNs by extracting road parts from input images, identifying the edges of the extracted road parts, and merging the parts of the images that contain the detected edges. In addition, a CNN model for end-to-end control is introduced. Experiments involving the Open Racing Car Simulator (TORCS, a sustainable computing environment for cars, confirmed the effectiveness of the proposed method for self-driving by comparing the accumulated difference in the angle of the steering wheel in the images generated by it with those of resized images containing the entire captured area and cropped images containing only a part of the captured area. The results showed that the proposed method reduced the accumulated difference by 0.839% and 0.850% compared to those yielded by the resized images and cropped images

  14. Uncharted terrain: preference construction at the end of life.

    White, Mary T

    2014-01-01

    Respect for patients' self-determination has long been considered central to efforts to improve end-of-life care, yet efforts to promote advance directives or engage patients in end-of-life discussions are often unsuccessful. In this article, I contend that this is because the shared decision-making approach typically used in healthcare assumes patients' capacity to make rational choices, which is not always possible in end-of-life decisions. Drawing on decision theory, behavioral psychology, and related studies of end-of-life care, I present a growing body of evidence that suggests the novelty, complexity, and uncertainty of end-of-life circumstances make rational and stable preferences difficult to establish. I argue that an effective decision-making approach for the terminally ill must recognize and respond to the unique characteristics of end-of-life choices, including their nonrational dimensions. I conclude with a description of an initiative that appears to do so, resulting in increased patients' satisfaction. Copyright 2014 The Journal of Clinical Ethics. All rights reserved.

  15. Dietary Advanced Glycation End Products and Aging

    Karen Chapman-Novakofski

    2010-12-01

    Full Text Available Advanced glycation end products (AGEs are a heterogeneous, complex group of compounds that are formed when reducing sugar reacts in a non-enzymatic way with amino acids in proteins and other macromolecules. This occurs both exogenously (in food and endogenously (in humans with greater concentrations found in older adults. While higher AGEs occur in both healthy older adults and those with chronic diseases, research is progressing to both quantify AGEs in food and in people, and to identify mechanisms that would explain why some human tissues are damaged, and others are not. In the last twenty years, there has been increased evidence that AGEs could be implicated in the development of chronic degenerative diseases of aging, such as cardiovascular disease, Alzheimer’s disease and with complications of diabetes mellitus. Results of several studies in animal models and humans show that the restriction of dietary AGEs has positive effects on wound healing, insulin resistance and cardiovascular diseases. Recently, the effect of restriction in AGEs intake has been reported to increase the lifespan in animal models. This paper will summarize the work that has been published for both food AGEs and in vivo AGEs and their relation with aging, as well as provide suggestions for future research.

  16. Ending Sexual Violence Through Transformative Justice

    Judith Armatta

    2018-02-01

    Full Text Available Sexual violence is used to maintain what Dr. Riane Eisler (1990 conceptualizes as the dominator model of society. The early days of the feminist anti-violence movement focused on changing the dominator model, but, in part, this focus was co-opted by seeking criminal justice solutions, contributing to punitive responses and mass incarceration that have been ineffective in ending sexual violence. The racist history of the rape charge and its disproportionate effect on people of color, an effect that continues today. Legislators have passed draconian laws that uniquely apply to anyone convicted of a sex offense, the definition of which has been broadened to encompass harmless behavior. A separate legal regime for sex offenders that isolates them from society and marks them for life as monsters obfuscates the causes of sexual violence and contributes to the problem. The feminist anti-violence movement remains influential, though little recognized, in today’s efforts to respond to sexual violence through restorative justice and transformative justice. A number of groups have adopted the RJ/TJ model, in particular women of color. The article provides examples of successful and unsuccessful implementation of RJ/TJ and discusses impediments to wider adoption of this approach. RJ/TJ is a promising alternative to the current criminal justice response to sexual assault, one that will bring us closer to a partnership culture.

  17. Parametric Study of End Milling Glass Fibre Reinforced Composites

    Azmi, Azwan I.; Lin, Richard J. T.; Bhattacharyya, Debes

    2011-01-01

    This paper discusses the application of Taguchi 'Design of Experiment' method to investigate the effects of end milling parameters on machinability characteristics of unidirectional E-glass fibre reinforced polymer (GFRP) composites. A series of milling experiments were conducted using tungsten carbide end milling cutters at various spindle speeds, feed rates and depths of cut. Taguchi analysis was carried out and the signal to noise (S/N) ratio with analysis of variance (ANOVA) was employed to analyse the effects of those parameters on GFRP machinability. Overall, the results of the current investigations present some desirable combinations of the machining parameters that can further enhance the end milling machinability characteristics to suit the final requirements of the finished GFRP products.

  18. Interfaces for End-User Information Seeking.

    Marchionini, Gary

    1992-01-01

    Discusses essential features of interfaces to support end-user information seeking. Highlights include cognitive engineering; task models and task analysis; the problem-solving nature of information seeking; examples of systems for end-users, including online public access catalogs (OPACs), hypertext, and help systems; and suggested research…

  19. 34 CFR 34.26 - Ending garnishment.

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Ending garnishment. 34.26 Section 34.26 Education Office of the Secretary, Department of Education ADMINISTRATIVE WAGE GARNISHMENT § 34.26 Ending... to pay any portion of the amount stated in the order, the employer must— (i) Notify us; and (ii...

  20. Det gående interview

    Rasmussen, Kim

    2017-01-01

    Det gående interview understøtter børns aktive deltagelse, og giver indblik i den materielle og kulturelle kontekst......Det gående interview understøtter børns aktive deltagelse, og giver indblik i den materielle og kulturelle kontekst...