WorldWideScience

Sample records for employee-to-employer cycle factors

  1. Circulating vascular endothelial growth factor during the normal menstrual cycle

    NARCIS (Netherlands)

    Kusumanto, YH; Hospers, GAP; Sluiter, WJ; Dam, WA; Meijer, C; Mulder, NH

    2004-01-01

    Background: The purpose of the study was to investigate whether cycle-related variations in circulating Vascular Endothelial Growth Factor (VEGF) levels would increase the metastatic potential at specific times during the menstrual cycle. Materials and Methods: VEGF levels in serum and whole blood

  2. Environmental factors affecting rates of nitrogen cycling

    International Nuclear Information System (INIS)

    Lipschultz, F.

    1984-01-01

    The nitrogen cycle in the eutrophic Delaware river was studied in late summer, 1983 using 15 N tracer additions of NHG 4 + , NO 2 - , and NO 3 - . Rates for nine different transformations were calculated simultaneously with a least-squares minimization analysis. Light was found to stimulate ammonium uptake and to inhibit ammonium oxidation. Rates for nitrification, ammonium uptake by phytoplankton, and photosynthesis were integrated over 24 hours and river depth. High turbidity lifted the effect of light inhibition on nitrification and restricted phytoplankton uptake. Uptake of ammonium contributed over 95% of the inorganic nitrogen ration for phytoplankton, with dark uptake accounting for more than 50%. A mass-conservation, box model of river was used to calculate rate constants required to reproduce observed nutrient concentration changes. The calculated constants correlated well with the measured 15 N and oxygen integrated rates. Water-column nitrification was the major loss term for NH 4 + , while water column regeneration was the primary source. Loss of oxidized nitrogen was insignificant. Oxygen consumption and air-water exchange far exceeded net photosynthetic oxygen production. Nitrification contributed less than 1% to the oxygen demand near Philadelphia but up to 25% further downstream. Production of NO and N 2 O was measured under varying oxygen concentrations in batch cultures of the nitrifying bacteria Nitrosomonas europaea and Nitrosococcus oceanus. Production of both gases increased relative to nitrite production as oxygen levels decreased

  3. Chinese life cycle impact assessment factors.

    Science.gov (United States)

    Yang, J X; Nielsen, P H

    2001-04-01

    The methodological basis and procedures for determination of Chinese normalization references and weighting factors according to the EDIP-method is described. According to Chinese industrial development intensity and population density, China was divided into three regions and the normalization references for each region were calculated on the basis of an inventory of all of the region's environmental emissions in 1990. The normalization reference was determined as the total environmental impact potential for the area in question in 1990 (EP(j)90) divided by the population. The weighting factor was determined as the normalization reference (ER(j)90) divided by society's target contribution in the year 2000 based on Chinese political reduction plans, ER(j)T2000. This paper presents and discuss results obtained for eight different environmental impact categories relevant for China: global warming, stratospheric ozone depletion, acidification, nutrient enrichment, photochemical ozone formation and generation of bulk waste, hazardous waste and slag and ashes.

  4. Chinese life cycle impact assessment factors

    DEFF Research Database (Denmark)

    Yang, Jianxin; Nielsen, Per Henning

    2001-01-01

    The methodological basis and procedures for determination of Chinese normalization references and weighting factors according to the EDIP-method is described. According to Chinese industrial development intensity and population density, China was divided into three regions and the normalization...... was determined as the normalization reference (ER ( j)90) divided by society's target contribution in the year 2000 abased on Chinese political reduction plans, ER ( j)(T2000). This paper presents and discuss results obtained for eight different environmental impact categories relevant for China: global warming...

  5. Factors which could limit the nuclear fuel cycle development

    International Nuclear Information System (INIS)

    Pecqueur, M.; Barre, B.

    1977-01-01

    The nuclear fuel cycle is a most important industry for the energy future of the world. It has also a leading part as regards the physical continuity of energy supply of the countries engaged in the nuclear field. The development of this industry is subject to the economic or political constraints involved by the availability of raw materials, technologies or production means. The various limiting factors which could affect the different stages of the fuel cycle are linked with the technical, economic and financial aspects, with the impact on the environment, nuclear safety, risks of non-pacific uses and proliferation of arms. Interesting to note is also the correlation between the fuel cycle development and the problems of energy independence and security of nuclear programs. As a conclusion, the nuclear fuel cycle industry is confronted to difficulties due to its extremely rapid growth (doubling time 5 years) which only few heavy industries have encountered for long periods. It is more over submitted to the political and safety constraints always linked with nuclear matters. The task is therefore a difficult one. But the objective is worth-while since it is a condition to the development of nuclear industry [fr

  6. Employee to employer communication skills: balancing cancer treatment and employment.

    Science.gov (United States)

    Brown, Richard F; Owens, Myra; Bradley, Cathy

    2013-02-01

    Cancer patients face difficulties in accessing legally mandated benefits and accommodations when they return to the workplace. Poor employer-employee communication inflates these difficulties. Although proven methods to facilitate physician-patient communication exist, these have not been applied to the workplace. Thus, we aimed to assess the feasibility and utility of applying these methods to educate patients about their workplace rights and provide them with communication skills training to aid their conversations with their employers. A DVD was produced to educate patients and facilitate workplace communication. Participants consisted of 28 solid tumor cancer patients (14 women and 14 men) who completed primary cancer treatment in the past 12 months and were employed at the time of diagnosis. Participants watched a communication skills training DVD and completed a telephone interview. The interview elicited information about workplace experiences and evaluation of the DVD training program. The physician-patient communication skills training model utilized was successfully translated to the employer-employee setting. All but one participant found the DVD useful and easy to understand and indicated a high degree of confidence in using the communication skills to help them ask for workplace accommodations. All participants agreed that it would help newly diagnosed patients in discussions with their employers. Our data provides promising preliminary evidence that patient communication skills training can be applied to the workplace setting and is a welcomed aid to newly diagnosed cancer patients in their discussions with employers regarding the impact of treatment on their work performance and needs for accommodations. Copyright © 2011 John Wiley & Sons, Ltd.

  7. Is There Really a Global Business Cycle? : A Dynamic Factor Model with Stochastic Factor Selection

    NARCIS (Netherlands)

    T. Berger (Tino); L.C.G. Pozzi (Lorenzo)

    2016-01-01

    textabstractWe investigate the presence of international business cycles in macroeconomic aggregates (output, consumption, investment) using a panel of 60 countries over the period 1961-2014. The paper presents a Bayesian stochastic factor selection approach for dynamic factor models with

  8. Characterisation factors for life cycle impact assessment of sound emissions.

    Science.gov (United States)

    Cucurachi, S; Heijungs, R

    2014-01-15

    Noise is a serious stressor affecting the health of millions of citizens. It has been suggested that disturbance by noise is responsible for a substantial part of the damage to human health. However, no recommended approach to address noise impacts was proposed by the handbook for life cycle assessment (LCA) of the European Commission, nor are characterisation factors (CFs) and appropriate inventory data available in commonly used databases. This contribution provides CFs to allow for the quantification of noise impacts on human health in the LCA framework. Noise propagation standards and international reports on acoustics and noise impacts were used to define the model parameters. Spatial data was used to calculate spatially-defined CFs in the form of 10-by-10-km maps. The results of this analysis were combined with data from the literature to select input data for representative archetypal situations of emission (e.g. urban day with a frequency of 63 Hz, rural night at 8000 Hz, etc.). A total of 32 spatial and 216 archetypal CFs were produced to evaluate noise impacts at a European level (i.e. EU27). The possibility of a user-defined characterisation factor was added to support the possibility of portraying the situation of full availability of information, as well as a highly-localised impact analysis. A Monte Carlo-based quantitative global sensitivity analysis method was applied to evaluate the importance of the input factors in determining the variance of the output. The factors produced are ready to be implemented in the available LCA databases and software. The spatial approach and archetypal approach may be combined and selected according to the amount of information available and the life cycle under study. The framework proposed and used for calculations is flexible enough to be expanded to account for impacts on target subjects other than humans and to continents other than Europe. © 2013 Elsevier B.V. All rights reserved.

  9. Applying Human Factors during the SIS Life Cycle

    International Nuclear Information System (INIS)

    Avery, K.

    2010-01-01

    Safety Instrumented Systems (SIS) are widely used in U.S. Department of Energy's (DOE) nonreactor nuclear facilities for safety-critical applications. Although use of the SIS technology and computer-based digital controls, can improve performance and safety, it potentially introduces additional complexities, such as failure modes that are not readily detectable. Either automated actions or manual (operator) actions may be required to complete the safety instrumented function to place the process in a safe state or mitigate a hazard in response to an alarm or indication. DOE will issue a new standard, Application of Safety Instrumented Systems Used at DOE Nonreactor Nuclear Facilities, to provide guidance for the design, procurement, installation, testing, maintenance, operation, and quality assurance of SIS used in safety significant functions at DOE nonreactor nuclear facilities. The DOE standard focuses on utilizing the process industry consensus standard, American National Standards Institute/ International Society of Automation (ANSI/ISA) 84.00.01, Functional Safety: Safety Instrumented Systems for the Process Industry Sector, to support reliable SIS design throughout the DOE complex. SIS design must take into account human-machine interfaces and their limitations and follow good human factors engineering (HFE) practices. HFE encompasses many diverse areas (e.g., information display, user-system interaction, alarm management, operator response, control room design, and system maintainability), which affect all aspects of system development and modification. This paper presents how the HFE processes and principles apply throughout the SIS life cycle to support the design and use of SIS at DOE nonreactor nuclear facilities.

  10. Present Worth Factors for Life-Cycle Cost Studies in the Department of Defense (1993)

    National Research Council Canada - National Science Library

    Petersen, Stephen R

    1992-01-01

    .... These factors are especially useful for the life cycle cost analysis of investments in buildings or building systems which are intended to reduce future operating, maintenance, repair, replacement...

  11. Systematic identification of yeast cell cycle transcription factors using multiple data sources

    Directory of Open Access Journals (Sweden)

    Li Wen-Hsiung

    2008-12-01

    Full Text Available Abstract Background Eukaryotic cell cycle is a complex process and is precisely regulated at many levels. Many genes specific to the cell cycle are regulated transcriptionally and are expressed just before they are needed. To understand the cell cycle process, it is important to identify the cell cycle transcription factors (TFs that regulate the expression of cell cycle-regulated genes. Results We developed a method to identify cell cycle TFs in yeast by integrating current ChIP-chip, mutant, transcription factor binding site (TFBS, and cell cycle gene expression data. We identified 17 cell cycle TFs, 12 of which are known cell cycle TFs, while the remaining five (Ash1, Rlm1, Ste12, Stp1, Tec1 are putative novel cell cycle TFs. For each cell cycle TF, we assigned specific cell cycle phases in which the TF functions and identified the time lag for the TF to exert regulatory effects on its target genes. We also identified 178 novel cell cycle-regulated genes, among which 59 have unknown functions, but they may now be annotated as cell cycle-regulated genes. Most of our predictions are supported by previous experimental or computational studies. Furthermore, a high confidence TF-gene regulatory matrix is derived as a byproduct of our method. Each TF-gene regulatory relationship in this matrix is supported by at least three data sources: gene expression, TFBS, and ChIP-chip or/and mutant data. We show that our method performs better than four existing methods for identifying yeast cell cycle TFs. Finally, an application of our method to different cell cycle gene expression datasets suggests that our method is robust. Conclusion Our method is effective for identifying yeast cell cycle TFs and cell cycle-regulated genes. Many of our predictions are validated by the literature. Our study shows that integrating multiple data sources is a powerful approach to studying complex biological systems.

  12. Alternative nuclear fuel cycle arrangements for proliferation resistance: an overview of regulatory factors

    International Nuclear Information System (INIS)

    O'Brien, J.N.

    1982-08-01

    President Carter proposed the International Fuel Cycle Evaluation to analyze various alternative fuel cycles which could minimize the risk of nuclear weapons proliferation. DOE also initiated the Non-Proliferation Alternative Systems Assessment Program. In response to GAO contentions that NRC was not sufficiently involved in these two assessments, a NRC study was initiated, with emphasis on legal and institutional factors. Objectives were to examine multinational fuel cycle facilities, potential effects on the US/IAEA agreement, development of an algorithm for ranking potential fuel cycles, and potential licensing of candidate fuel cycles. This anthology represents the products of this study which has been conducted between 1979 and 1981

  13. Identification of transcription factors linked to cell cycle regulation in Arabidopsis

    OpenAIRE

    Dehghan Nayeri, Fatemeh

    2014-01-01

    Cell cycle is an essential process in growth and development of living organisms consists of the replication and mitotic phases separated by 2 gap phases; G1 and G2. It is tightly controlled at the molecular level and especially at the level of transcription. Precise regulation of the cell cycle is of central significance for plant growth and development and transcription factors are global regulators of gene expression playing essential roles in cell cycle regulation. This study has uncovere...

  14. Critical environmental factors for transportation cycling in children: a qualitative study using bike-along interviews.

    Science.gov (United States)

    Ghekiere, Ariane; Van Cauwenberg, Jelle; de Geus, Bas; Clarys, Peter; Cardon, Greet; Salmon, Jo; De Bourdeaudhuij, Ilse; Deforche, Benedicte

    2014-01-01

    Environmental factors are found to influence transport-related physical activity, but have rarely been studied in relation with cycling for transport to various destinations in 10-12 yr old children. The current qualitative study used 'bike-along interviews' with children and parents to allow discussion of detailed environmental factors that may influence children's cycling for transport, while cycling in the participant's neighborhood. Purposeful convenience sampling was used to recruit 35 children and one of their parents residing in (semi-) urban areas. Bike-along interviews were conducted to and from a randomly chosen destination (e.g. library) within a 15 minutes' cycle trip in the participant's neighborhood. Participants wore a GoPro camera to objectively assess environmental elements, which were subsequently discussed with participants. Content analysis and arising themes were derived using a grounded theory approach. The discussed environmental factors were categorized under traffic, urban design, cycling facilities, road design, facilities at destination, aesthetics, topography, weather, social control, stranger danger and familiar environment. Across these categories many environmental factors were (in)directly linked to road safety. This was illustrated by detailed discussions of the children's visibility, familiarity with specific traffic situations, and degree of separation, width and legibility of cycle facilities. Road safety is of major concern in this 10-12 yr old study population. Bike-along interviews were able to identify new, detailed and context-specific physical environmental factors which could inform policy makers to promote children's cycling for transport. However, future studies should investigate whether hypothetical changes to such micro environmental features influence perceptions of safety and if this in turn could lead to changes in children's cycling for transport.

  15. Critical environmental factors for transportation cycling in children: a qualitative study using bike-along interviews.

    Directory of Open Access Journals (Sweden)

    Ariane Ghekiere

    Full Text Available Environmental factors are found to influence transport-related physical activity, but have rarely been studied in relation with cycling for transport to various destinations in 10-12 yr old children. The current qualitative study used 'bike-along interviews' with children and parents to allow discussion of detailed environmental factors that may influence children's cycling for transport, while cycling in the participant's neighborhood.Purposeful convenience sampling was used to recruit 35 children and one of their parents residing in (semi- urban areas. Bike-along interviews were conducted to and from a randomly chosen destination (e.g. library within a 15 minutes' cycle trip in the participant's neighborhood. Participants wore a GoPro camera to objectively assess environmental elements, which were subsequently discussed with participants. Content analysis and arising themes were derived using a grounded theory approach.The discussed environmental factors were categorized under traffic, urban design, cycling facilities, road design, facilities at destination, aesthetics, topography, weather, social control, stranger danger and familiar environment. Across these categories many environmental factors were (indirectly linked to road safety. This was illustrated by detailed discussions of the children's visibility, familiarity with specific traffic situations, and degree of separation, width and legibility of cycle facilities.Road safety is of major concern in this 10-12 yr old study population. Bike-along interviews were able to identify new, detailed and context-specific physical environmental factors which could inform policy makers to promote children's cycling for transport. However, future studies should investigate whether hypothetical changes to such micro environmental features influence perceptions of safety and if this in turn could lead to changes in children's cycling for transport.

  16. Regulation of the yeast metabolic cycle by transcription factors with periodic activities

    Directory of Open Access Journals (Sweden)

    Pellegrini Matteo

    2011-10-01

    Full Text Available Abstract Background When growing budding yeast under continuous, nutrient-limited conditions, over half of yeast genes exhibit periodic expression patterns. Periodicity can also be observed in respiration, in the timing of cell division, as well as in various metabolite levels. Knowing the transcription factors involved in the yeast metabolic cycle is helpful for determining the cascade of regulatory events that cause these patterns. Results Transcription factor activities were estimated by linear regression using time series and genome-wide transcription factor binding data. Time-translation matrices were estimated using least squares and were used to model the interactions between the most significant transcription factors. The top transcription factors have functions involving respiration, cell cycle events, amino acid metabolism and glycolysis. Key regulators of transitions between phases of the yeast metabolic cycle appear to be Hap1, Hap4, Gcn4, Msn4, Swi6 and Adr1. Conclusions Analysis of the phases at which transcription factor activities peak supports previous findings suggesting that the various cellular functions occur during specific phases of the yeast metabolic cycle.

  17. The factor of time in the life cycle assessment of housing

    NARCIS (Netherlands)

    Klunder, G.; van Nunen, H.

    2003-01-01

    Conducting life cycle assessments, or LCAs, involves many uncertainties, including those related to the factor of time. Time is very important in the environmental assessment of housing, because of the relatively long service life of houses. During a house's service life many changes occur, which

  18. Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts

    International Nuclear Information System (INIS)

    DiCicco-Bloom, E.; Black, I.B.

    1988-01-01

    While neuronal mitosis is uniquely restricted to early development, the underlying regulation remains to be defined. The authors have now developed a dissociated, embryonic sympathetic neuron culture system that uses fully defined medium in which cells enter the mitotic cycle. The cultured cells expressed two neuronal traits, tyrosine hydroxylase and the neuron-specific 160-kDa neurofilament subunit protein, but were devoid of glial fibrillary acidic protein, a marker for non-myelin-forming Schwann cells in ganglia. Approximately one-third of the tyrosine hydroxylase-positive cells synthesized DNA in culture, specifically incorporating [ 3 H]thymidine into their nuclei. They used this system to define factors regulating the mitotic cycle in sympathetic neuroblasts. Members of the insulin family of growth factors, including insulin and insulin-like growth factors I and II, regulated DNA synthesis in the presumptive neuroblasts. Insulin more than doubled the proportion of tyrosine hydroxylase-positive cells entering the mitotic cycle, as indicated by autoradiography of [ 3 H]thymidine incorporation into nuclei. Scintillation spectrometry was an even more sensitive index of DNA synthesis. In contrast, the trophic protein nerve growth factor exhibited no mitogenic effect, suggesting that the mitogenic action of insulin growth factors is highly specific. The observations are discussed in the context of the detection of insulin growth factors and receptors in the developing brain

  19. Evaluation of life-cycle air emission factors of freight transportation.

    Science.gov (United States)

    Facanha, Cristiano; Horvath, Arpad

    2007-10-15

    Life-cycle air emission factors associated with road, rail, and air transportation of freight in the United States are analyzed. All life-cycle phases of vehicles, infrastructure, and fuels are accounted for in a hybrid life-cycle assessment (LCA). It includes not only fuel combustion, but also emissions from vehicle manufacturing, maintenance, and end of life, infrastructure construction, operation, maintenance, and end of life, and petroleum exploration, refining, and fuel distribution. Results indicate that total life-cycle emissions of freight transportation modes are underestimated if only tailpipe emissions are accounted for. In the case of CO2 and NOx, tailpipe emissions underestimate total emissions by up to 38%, depending on the mode. Total life-cycle emissions of CO and SO2 are up to seven times higher than tailpipe emissions. Sensitivity analysis considers the effects of vehicle type, geography, and mode efficiency on the final results. Policy implications of this analysis are also discussed. For example, while it is widely assumed that currently proposed regulations will result in substantial reductions in emissions, we find that this is true for NOx, emissions, because fuel combustion is the main cause, and to a lesser extent for SO2, but not for PM10 emissions, which are significantly affected by the other life-cycle phases.

  20. Dieting and weight cycling as risk factors for cardiometabolic diseases: who is really at risk?

    Science.gov (United States)

    Montani, J-P; Schutz, Y; Dulloo, A G

    2015-02-01

    Despite the poor prognosis of dieting in obesity management, which often results in repeated attempts at weight loss and hence weight cycling, the prevalence of dieting has increased continuously in the past decades in parallel to the steadily increasing prevalence of obesity. However, dieting and weight cycling are not limited to those who are obese or overweight as substantial proportions of the various population groups with normal body weight also attempt to lose weight. These include young and older adults as well as children and adolescents who perceive themselves as too fat (due to media, parental and social pressures), athletes in weight-sensitive competitive sports (i.e. mandatory weight categories, gravitational and aesthetic sports) or among performers for whom a slim image is professionally an advantage. Of particular concern is the emergence of evidence that some of the potentially negative health consequences of repeated dieting and weight cycling are more readily seen in people of normal body weight rather than in those who are overweight or obese. In particular, several metabolic and cardiovascular risk factors associated with weight cycling in normal-weight individuals have been identified from cross-sectional and prospective studies as well as from studies of experimentally induced weight cycling. In addition, findings from studies of experimental weight cycling have reinforced the notion that fluctuations of cardiovascular risk variables (such as blood pressure, heart rate, sympathetic activity, blood glucose, lipids and insulin) with probable repeated overshoots above normal values during periods of weight regain put an additional stress on the cardiovascular system. As the prevalence of diet-induced weight cycling is increasing due to the opposing forces of an 'obesigenic' environment and the media pressure for a slim figure (that even targets children), dieting and weight cycling is likely to become an increasingly serious public health issue

  1. The US Business Cycle, 1867-2006: A Dynamic Factor Approach

    OpenAIRE

    Ritschl, Albrecht; Sarferaz, Samad; Uebele, Martin

    2016-01-01

    We estimate a Stock/Watson index of economic activity to assess U.S. business cycle volatility since 1867. We replicate the Great Moderation of the 1980s and 1990s and find exceptionally low volatility also in the Golden Age of the 1960s. Postwar moderation relative to pre-1914 occurs under constant but not time-varying factor loadings, suggesting structural change toward more volatile sectors. For comparable series, the U.S. postwar business cycle was as volatile overall as under the Classic...

  2. ANALYSIS OF RISK FACTORS AT THE STAGE OF THE PRODUCT LIFE CYCLE

    Directory of Open Access Journals (Sweden)

    N. Skopenko

    2016-10-01

    Full Text Available The article outlines and summarizes the risks of enterprises at different stages of product life cycle. A diagnose and assess of risks according to the main stages of the product development are offered. Groups of factors that shape the economic risks at different stages of the product life cycle, by the possible negative consequences of their impact are formulated. To reduce the probable losses of the company and a reasonable assortment portfolio formation generalized classification of risks that are typical for any company is proposed.

  3. How to assess performance in cycling: the multivariate nature of influencing factors and related indicators

    Science.gov (United States)

    Castronovo, A. Margherita; Conforto, Silvia; Schmid, Maurizio; Bibbo, Daniele; D'Alessio, Tommaso

    2013-01-01

    Finding an optimum for the cycling performance is not a trivial matter, since the literature shows the presence of many controversial aspects. In order to quantify different levels of performance, several indexes have been defined and used in many studies, reflecting variations in physiological and biomechanical factors. In particular, indexes such as Gross Efficiency (GE), Net Efficiency (NE) and Delta Efficiency (DE) have been referred to changes in metabolic efficiency (EffMet), while the Indexes of Effectiveness (IE), defined over the complete crank revolution or over part of it, have been referred to variations in mechanical effectiveness (EffMech). All these indicators quantify the variations of different factors [i.e., muscle fibers type distribution, pedaling cadence, setup of the bicycle frame, muscular fatigue (MFat), environmental variables, ergogenic aids, psychological traits (PsychTr)], which, moreover, show high mutual correlation. In the attempt of assessing cycling performance, most studies in the literature keep all these factors separated. This may bring to misleading results, leaving unanswered the question of how to improve cycling performance. This work provides an overview on the studies involving indexes and factors usually related to performance monitoring and assessment in cycling. In particular, in order to clarify all those aspects, the mutual interactions among these factors are highlighted, in view of a global performance assessment. Moreover, a proposal is presented advocating for a model-based approach that considers all factors mentioned in the survey, including the mutual interaction effects, for the definition of an objective function E representing the overall effectiveness of a training program in terms of both EffMet and EffMech. PMID:23734130

  4. How to Assess Performance in Cycling: the Multivariate Nature of Influencing Factors and Related Indicators.

    Directory of Open Access Journals (Sweden)

    Anna Margherita eCastronovo

    2013-05-01

    Full Text Available Finding an optimum for the cycling performance is not a trivial matter, since the literature shows the presence of many controversial aspects. In order to quantify different levels of performance, several indexes have been defined and used in many studies, reflecting variations in physiological and biomechanical factors. In particular, indexes such as Gross Efficiency (GE, Net Efficiency (NE and Delta Efficiency (DE have been referred to changes in metabolic efficiency (EffMet, while the Indexes of Effectiveness (IE, defined over the complete crank revolution or over part of it, have been referred to variations in mechanical effectiveness (EffMech. All these indicators quantify the variations of different factors (i.e. muscle fibers type distribution, pedaling cadence, setup of the bicycle frame, muscular fatigue, environmental variables, ergogenic aids, psychological traits, which, moreover, show high mutual correlation. In the attempt of assessing cycling performance, most studies in the literature keep all these factors separated. This may bring to misleading results, leaving unanswered the question of how to improve cycling performance. This work provides an overview on the studies involving indexes and factors usually related to performance monitoring and assessment in cycling. In particular, in order to clarify all those aspects, the mutual interactions among these factors are highlighted, in view of a global performance assessment. Moreover, a proposal is presented advocating for a model-based approach that considers all factors mentioned in the survey, including the mutual interaction effects, for the definition of an objective function E representing the overall effectiveness of a training program in terms of both metabolic efficiency and mechanical effectiveness.

  5. Sustainable Development Factors in Pavement Life-Cycle: Highway/Airport Review

    Directory of Open Access Journals (Sweden)

    Peyman Babashamsi

    2016-03-01

    Full Text Available Sustainability has gained as much importance as management in business. Sustainable pavement development as a business practice should involve making evaluations according to the triple bottom line in the pavement life-cycle. Despite the current approaches to evaluating the social as well as economic and environmental feasibility of pavement projects (involving highway and airport infrastructure, there has recently been a lack of consensus on a methodology to guarantee sustainability upon assessment and analysis during the pavement life-cycle. As sustainability is a complex issue, this study intends to further explore sustainability and elaborate on its meaning. The second step involves a general depiction of the major sustainability appraisal tools, namely cost-benefit analysis, life-cycle cost analysis, life-cycle assessment, multi-criteria decision-making, environmental impact assessment and social life-cycle assessment, and an explanation of their cons and pros. Subsequently, the article addresses the application of an organized methodology to highlight the main factors or concepts that should be applied in sustainable pavement development and, more specifically, in sustainable pavement management. In the final step, research recommendations toward sustainability are given. This study is aimed to assist decision-makers in pavement management to plan sustainability frameworks in accordance with probable boundaries and restrictions.

  6. Influence of Geographic Factors on the Life Cycle Climate Change Impacts of Renewable Energy Systems

    Science.gov (United States)

    Fortier, M. O. P.

    2017-12-01

    Life cycle assessment (LCA) is a valuable tool to measure the cradle-to-grave climate change impacts of the sustainable energy systems that are planned to replace conventional fossil energy-based systems. The recent inclusion of geographic specificity in bioenergy LCAs has shown that the relative sustainability of these energy sources is often dependent on geographic factors, such as the climate change impact of changing the land cover and local resource availability. However, this development has not yet been implemented to most LCAs of energy systems that do not have biological feedstocks, such as wind, water, and solar-based energy systems. For example, the tidal velocity where tidal rotors are installed can significantly alter the life cycle climate change impacts of electricity generated using the same technology in different locations. For LCAs of solar updraft towers, the albedo change impacts arising from changing the reflectivity of the land that would be converted can be of the same magnitude as other life cycle process climate change impacts. Improvements to determining the life cycle climate change impacts of renewable energy technologies can be made by utilizing GIS and satellite data and by conducting site-specific analyses. This practice can enhance our understanding of the life cycle environmental impacts of technologies that are aimed to reduce the impacts of our current energy systems, and it can improve the siting of new systems to optimize a reduction in climate change impacts.

  7. Quality factors in the life cycle of software oriented to safety systems in nuclear power plants

    International Nuclear Information System (INIS)

    Nunez McLeod, J.E.; Rivera, S.S.

    1997-01-01

    The inclusion of software in safety related systems for nuclear power plants, makes it necessary to include the software quality assurance concept. The software quality can be defined as the adjustment degree between the software and the specified requirements and user expectations. To guarantee a certain software quality level it is necessary to make a systematic and planned set of tasks, that constitute a software quality guaranty plan. The application of such a plan involves activities that should be performed all along the software life cycle, and that can be evaluated through the so called quality factors, due to the fact that the quality itself cannot be directly measured, but indirectly as some of it manifestations. In this work, a software life cycle model is proposed, for nuclear power plant safety related systems. A set os software quality factors is also proposed , with its corresponding classification according to the proposed model. (author) [es

  8. Elevated levels of plasma brain derived neurotrophic factor in rapid cycling bipolar disorder patients

    DEFF Research Database (Denmark)

    Munkholm, Klaus; Pedersen, Bente Klarlund; Kessing, Lars Vedel

    2014-01-01

    Impaired neuroplasticity may be implicated in the pathophysiology of bipolar disorder, involving peripheral alterations of the neurotrophins brain derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3). Evidence is limited by methodological issues and is based primarily on case-control desi......Impaired neuroplasticity may be implicated in the pathophysiology of bipolar disorder, involving peripheral alterations of the neurotrophins brain derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3). Evidence is limited by methodological issues and is based primarily on case......-control designs. The aim of this study was to investigate whether BDNF and NT-3 levels differ between patients with rapid cycling bipolar disorder and healthy control subjects and whether BDNF and NT-3 levels alter with affective states in rapid cycling bipolar disorder patients. Plasma levels of BDNF and NT-3......, levels of BDNF were significantly elevated in bipolar disorder patients in euthymic- (pdifference in BDNF levels...

  9. Human Factors Throughout the Life Cycle: Lessons Learned from the Shuttle Program. [Human Factors in Ground Processing

    Science.gov (United States)

    Kanki, Barbara G.

    2011-01-01

    With the ending of the Space Shuttle Program, it is critical that we not forget the Human Factors lessons we have learned over the years. At every phase of the life cycle, from manufacturing, processing and integrating vehicle and payload, to launch, flight operations, mission control and landing, hundreds of teams have worked together to achieve mission success in one of the most complex, high-risk socio-technical enterprises ever designed. Just as there was great diversity in the types of operations performed at every stage, there was a myriad of human factors that could further complicate these human systems. A single mishap or close call could point to issues at the individual level (perceptual or workload limitations, training, fatigue, human error susceptibilities), the task level (design of tools, procedures and aspects of the workplace), as well as the organizational level (appropriate resources, safety policies, information access and communication channels). While we have often had to learn through human mistakes and technological failures, we have also begun to understand how to design human systems in which individuals can excel, where tasks and procedures are not only safe but efficient, and how organizations can foster a proactive approach to managing risk and supporting human enterprises. Panelists will talk about their experiences as they relate human factors to a particular phase of the shuttle life cycle. They will conclude with a framework for tying together human factors lessons-learned into system-level risk management strategies.

  10. Development and review of Euro 5 passenger car emission factors based on experimental results over various driving cycles

    OpenAIRE

    Fontaras, Georgios; Franco, Vicente; Dilara, Panagiota; Martini, Giorgio; Manfredi, Urbano

    2014-01-01

    The mass emissions of CO2 and regulated pollutants (NOX, HC, CO, PM) of thirteen Euro 5 compliant passenger cars (seven gasoline, six Diesel) were measured on a chassis dynamometer. The vehicles were driven repeatedly over the European type-approval driving cycle (NEDC) and the more dynamic WMTC and CADC driving cycles. Distance-specific emission factors were derived for each pollutant and sub-cycle which were subsequently compared to the corresponding emission factors provided by the referen...

  11. An integrated factor analysis model for product eco-design based on full life cycle assessment

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Z.; Xiao, T.; Li, D.

    2016-07-01

    Among the methods of comprehensive analysis for a product or an enterprise, there exist defects and deficiencies in traditional standard cost analyses and life cycle assessment methods. For example, some methods only emphasize one dimension (such as economic or environmental factors) while neglecting other relevant dimensions. This paper builds a factor analysis model of resource value flow, based on full life cycle assessment and eco-design theory, in order to expose the relevant internal logic between these two factors. The model considers the efficient multiplication of resources, economic efficiency, and environmental efficiency as its core objectives. The model studies the status of resource value flow during the entire life cycle of a product, and gives an in-depth analysis on the mutual logical relationship of product performance, value, resource consumption, and environmental load to reveal the symptoms and potentials in different dimensions. This provides comprehensive, accurate and timely decision-making information for enterprise managers regarding product eco-design, as well as production and management activities. To conclude, it verifies the availability of this evaluation and analysis model using a Chinese SUV manufacturer as an example. (Author)

  12. Computing the Stretch Factor of Paths, Trees, and Cycles in Weighted Fixed Orientation Metrics

    DEFF Research Database (Denmark)

    Wulff-Nilsen, Christian

    2008-01-01

    Let G be a graph embedded in the L_1-plane. The stretch factor of G is the maximum over all pairs of distinct vertices p and q of G of the ratio L_1^G(p,q)/L_1(p,q), where L_1^G(p,q) is the L_1-distance in G between p and q. We show how to compute the stretch factor of an n-vertex path in O(n*(log...... n)^2) worst-case time and O(n) space and we mention generalizations to trees and cycles, to general weighted fixed orientation metrics, and to higher dimensions....

  13. The transcription factor bZIP14 regulates the TCA cycle in the diatom Phaeodactylum tricornutum.

    Science.gov (United States)

    Matthijs, Michiel; Fabris, Michele; Obata, Toshihiro; Foubert, Imogen; Franco-Zorrilla, José Manuel; Solano, Roberto; Fernie, Alisdair R; Vyverman, Wim; Goossens, Alain

    2017-06-01

    Diatoms are amongst the most important marine microalgae in terms of biomass, but little is known concerning the molecular mechanisms that regulate their versatile metabolism. Here, the pennate diatom Phaeodactylum tricornutum was studied at the metabolite and transcriptome level during nitrogen starvation and following imposition of three other stresses that impede growth. The coordinated upregulation of the tricarboxylic acid (TCA) cycle during the nitrogen stress response was the most striking observation. Through co-expression analysis and DNA binding assays, the transcription factor bZIP14 was identified as a regulator of the TCA cycle, also beyond the nitrogen starvation response, namely in diurnal regulation. Accordingly, metabolic and transcriptional shifts were observed upon overexpression of bZIP14 in transformed P. tricornutum cells. Our data indicate that the TCA cycle is a tightly regulated and important hub for carbon reallocation in the diatom cell during nutrient starvation and that bZIP14 is a conserved regulator of this cycle. © 2017 The Authors.

  14. Factors for a successful sales force during the corporate life cycle

    Directory of Open Access Journals (Sweden)

    Adrian Gelu LUPU

    2009-06-01

    Full Text Available The organisations, like all living organisms, have a lifecycle and undergo very predictable and repetitive patterns of behaviour as they grow and develop. Although companies devote considerable time and money to managing their sales forces, few focus much on how the sale forces needs to change over the life cycle of an organisation. In this article, the authors explain how, at each stage, company can best tackle the relevant issues and get the most out of their sales forces, how to develop the best sales force structures for each of the four stages of the business life cycle. Specifically, companies must alter four factors over time: the roles that the sales force and selling partners play, the size of the sales force, the sales force’s degree of specialization, and how salespeople apportion their efforts among different customers, products and activities.

  15. Cycle Inhibiting Factors (Cifs: Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells

    Directory of Open Access Journals (Sweden)

    Eric Oswald

    2011-03-01

    Full Text Available Cycle inhibiting factors (Cifs are type III secreted effectors produced by diverse pathogenic bacteria. Cifs are “cyclomodulins” that inhibit the eukaryotic host cell cycle and also hijack other key cellular processes such as those controlling the actin network and apoptosis. This review summarizes current knowledge on Cif since its first characterization in enteropathogenic Escherichia coli, the identification of several xenologues in distant pathogenic bacteria, to its structure elucidation and the recent deciphering of its mode of action. Cif impairs the host ubiquitin proteasome system through deamidation of ubiquitin or the ubiquitin-like protein NEDD8 that regulates Cullin-Ring-ubiquitin Ligase (CRL complexes. The hijacking of the ubiquitin-dependent degradation pathway of host cells results in the modulation of various cellular functions such as epithelium renewal, apoptosis and immune response. Cif is therefore a powerful weapon in the continuous arm race that characterizes host-bacteria interactions.

  16. Environmental science. Rethinking the marine carbon cycle: factoring in the multifarious lifestyles of microbes.

    Science.gov (United States)

    Worden, Alexandra Z; Follows, Michael J; Giovannoni, Stephen J; Wilken, Susanne; Zimmerman, Amy E; Keeling, Patrick J

    2015-02-13

    The profound influence of marine plankton on the global carbon cycle has been recognized for decades, particularly for photosynthetic microbes that form the base of ocean food chains. However, a comprehensive model of the carbon cycle is challenged by unicellular eukaryotes (protists) having evolved complex behavioral strategies and organismal interactions that extend far beyond photosynthetic lifestyles. As is also true for multicellular eukaryotes, these strategies and their associated physiological changes are difficult to deduce from genome sequences or gene repertoires—a problem compounded by numerous unknown function proteins. Here, we explore protistan trophic modes in marine food webs and broader biogeochemical influences. We also evaluate approaches that could resolve their activities, link them to biotic and abiotic factors, and integrate them into an ecosystems biology framework. Copyright © 2015, American Association for the Advancement of Science.

  17. Diurnal Cycling Transcription Factors of Pineapple Revealed by Genome-Wide Annotation and Global Transcriptomic Analysis.

    Science.gov (United States)

    Sharma, Anupma; Wai, Ching Man; Ming, Ray; Yu, Qingyi

    2017-09-01

    Circadian clock provides fitness advantage by coordinating internal metabolic and physiological processes to external cyclic environments. Core clock components exhibit daily rhythmic changes in gene expression, and the majority of them are transcription factors (TFs) and transcription coregulators (TCs). We annotated 1,398 TFs from 67 TF families and 80 TCs from 20 TC families in pineapple, and analyzed their tissue-specific and diurnal expression patterns. Approximately 42% of TFs and 45% of TCs displayed diel rhythmic expression, including 177 TF/TCs cycling only in the nonphotosynthetic leaf tissue, 247 cycling only in the photosynthetic leaf tissue, and 201 cycling in both. We identified 68 TF/TCs whose cycling expression was tightly coupled between the photosynthetic and nonphotosynthetic leaf tissues. These TF/TCs likely coordinate key biological processes in pineapple as we demonstrated that this group is enriched in homologous genes that form the core circadian clock in Arabidopsis and includes a STOP1 homolog. Two lines of evidence support the important role of the STOP1 homolog in regulating CAM photosynthesis in pineapple. First, STOP1 responds to acidic pH and regulates a malate channel in multiple plant species. Second, the cycling expression pattern of the pineapple STOP1 and the diurnal pattern of malate accumulation in pineapple leaf are correlated. We further examined duplicate-gene retention and loss in major known circadian genes and refined their evolutionary relationships between pineapple and other plants. Significant variations in duplicate-gene retention and loss were observed for most clock genes in both monocots and dicots. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  18. Primary granulocyte colony-stimulating factor prophylaxis during the first two cycles only or throughout all chemotherapy cycles in patients with breast cancer at risk for febrile neutropenia.

    Science.gov (United States)

    Aarts, Maureen J; Peters, Frank P; Mandigers, Caroline M; Dercksen, M Wouter; Stouthard, Jacqueline M; Nortier, Hans J; van Laarhoven, Hanneke W; van Warmerdam, Laurence J; van de Wouw, Agnes J; Jacobs, Esther M; Mattijssen, Vera; van der Rijt, Carin C; Smilde, Tineke J; van der Velden, Annette W; Temizkan, Mehmet; Batman, Erdogan; Muller, Erik W; van Gastel, Saskia M; Borm, George F; Tjan-Heijnen, Vivianne C G

    2013-12-01

    Early breast cancer is commonly treated with anthracyclines and taxanes. However, combining these drugs increases the risk of myelotoxicity and may require granulocyte colony-stimulating factor (G-CSF) support. The highest incidence of febrile neutropenia (FN) and largest benefit of G-CSF during the first cycles of chemotherapy lead to questions about the effectiveness of continued use of G-CSF throughout later cycles of chemotherapy. In a multicenter study, patients with breast cancer who were considered fit enough to receive 3-weekly polychemotherapy, but also had > 20% risk for FN, were randomly assigned to primary G-CSF prophylaxis during the first two chemotherapy cycles only (experimental arm) or to primary G-CSF prophylaxis throughout all chemotherapy cycles (standard arm). The noninferiority hypothesis was that the incidence of FN would be maximally 7.5% higher in the experimental compared with the standard arm. After inclusion of 167 eligible patients, the independent data monitoring committee advised premature study closure. Of 84 patients randomly assigned to G-CSF throughout all chemotherapy cycles, eight (10%) experienced an episode of FN. In contrast, of 83 patients randomly assigned to G-CSF during the first two cycles only, 30 (36%) had an FN episode (95% CI, 0.13 to 0.54), with a peak incidence of 24% in the third cycle (ie, first cycle without G-CSF prophylaxis). In patients with early breast cancer at high risk for FN, continued use of primary G-CSF prophylaxis during all chemotherapy cycles is of clinical relevance and thus cannot be abandoned.

  19. Situational Awareness: Regulation of the Myb Transcription Factor in Differentiation, the Cell Cycle and Oncogenesis

    Energy Technology Data Exchange (ETDEWEB)

    George, Olivia L.; Ness, Scott A., E-mail: sness@salud.unm.edu [Department of Internal Medicine, Section of Molecular Medicine, University of New Mexico Health Sciences Center, MSC07 4025-CRF 121, 1 University of New Mexico, Albuquerque, NM 87131 (United States)

    2014-10-02

    This review summarizes the mechanisms that control the activity of the c-Myb transcription factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of the cell cycle. Oncogenic versions of c-Myb contribute to the development of leukemias and solid tumors such as adenoid cystic carcinoma, breast cancer and colon cancer. The activity and specificity of the c-Myb protein seems to be controlled through changes in protein-protein interactions, so understanding how it is regulated could lead to the development of novel therapeutic strategies.

  20. Land and Water Use, CO2 Emissions, and Worker Radiological Exposure Factors for the Nuclear Fuel Cycle

    Energy Technology Data Exchange (ETDEWEB)

    Brett W Carlsen; Brent W Dixon; Urairisa Pathanapirom; Eric Schneider; Bethany L. Smith; Timothy M. AUlt; Allen G. Croff; Steven L. Krahn

    2013-08-01

    The Department of Energy Office of Nuclear Energy’s Fuel Cycle Technologies program is preparing to evaluate several proposed nuclear fuel cycle options to help guide and prioritize Fuel Cycle Technology research and development. Metrics are being developed to assess performance against nine evaluation criteria that will be used to assess relevant impacts resulting from all phases of the fuel cycle. This report focuses on four specific environmental metrics. • land use • water use • CO2 emissions • radiological Dose to workers Impacts associated with the processes in the front-end of the nuclear fuel cycle, mining through enrichment and deconversion of DUF6 are summarized from FCRD-FCO-2012-000124, Revision 1. Impact estimates are developed within this report for the remaining phases of the nuclear fuel cycle. These phases include fuel fabrication, reactor construction and operations, fuel reprocessing, and storage, transport, and disposal of associated used fuel and radioactive wastes. Impact estimates for each of the phases of the nuclear fuel cycle are given as impact factors normalized per unit process throughput or output. These impact factors can then be re-scaled against the appropriate mass flows to provide estimates for a wide range of potential fuel cycles. A companion report, FCRD-FCO-2013-000213, applies the impact factors to estimate and provide a comparative evaluation of 40 fuel cycles under consideration relative to these four environmental metrics.

  1. Expression of the epidermal growth factor system in human endometrium during the menstrual cycle

    DEFF Research Database (Denmark)

    Ejskjaer, Kirsten; Sørensen, B S; Poulsen, Steen Seier

    2005-01-01

    The epidermal growth factor (EGF) system is ubiquitous in humans and plays fundamental roles in embryogenesis, development, proliferation and differentiation. As the endometrium of fertile women is characterized by proliferation and differentiation, we hypothesize a role for the EGF system....... Fourteen premenopausal women had endometrial samples removed on day 6 +/- 1 and day 6 +/- 1 and 12 +/- 1 after ovulation during one menstrual cycle. RNA was extracted and analysed by real-time PCR, and immunohistochemistry was performed to localize the components of the EGF system. Human EGF Receptor 1...... (HER1) showed highest expression during the proliferative phase, HER2 and HER4 during the early and HER3 during the late secretory phase. Amphiregulin (AR) and transforming growth factor alpha (TGFalpha) expression is highest in proliferative phase. Heparin binding (HB)-EGF and betacellulin (BCL) show...

  2. Epigenetic control of viral life-cycle by a DNA-methylation dependent transcription factor.

    Directory of Open Access Journals (Sweden)

    Kirsty Flower

    Full Text Available Epstein-Barr virus (EBV encoded transcription factor Zta (BZLF1, ZEBRA, EB1 is the prototype of a class of transcription factor (including C/EBPalpha that interact with CpG-containing DNA response elements in a methylation-dependent manner. The EBV genome undergoes a biphasic methylation cycle; it is extensively methylated during viral latency but is reset to an unmethylated state following viral lytic replication. Zta is expressed transiently following infection and again during the switch between latency and lytic replication. The requirement for CpG-methylation at critical Zta response elements (ZREs has been proposed to regulate EBV replication, specifically it could aid the activation of viral lytic gene expression from silenced promoters on the methylated genome during latency in addition to preventing full lytic reactivation from the non-methylated EBV genome immediately following infection. We developed a computational approach to predict the location of ZREs which we experimentally assessed using in vitro and in vivo DNA association assays. A remarkably different binding motif is apparent for the CpG and non-CpG ZREs. Computational prediction of the location of these binding motifs in EBV revealed that the majority of lytic cycle genes have at least one and many have multiple copies of methylation-dependent CpG ZREs within their promoters. This suggests that the abundance of Zta protein coupled with the methylation status of the EBV genome act together to co-ordinate the expression of lytic cycle genes at the majority of EBV promoters.

  3. Life cycle and reproduction of house-dust mites: environmental factors influencing mite populations.

    Science.gov (United States)

    Hart, B J

    1998-01-01

    An understanding of the life cycle of house-dust mites, as well as environmental factors influencing mite populations, can be exploited in mite control. The most important limiting factor for house-dust-mite populations is air humidity. House-dust mites osmoregulate through the cuticle and therefore require a high ambient air humidity to prevent excessive water loss. In addition, the supracoxal glands actively take up ambient water vapour, and the protonynph stage of the life cycle is resistant to desiccation. Larger house-dust-mite populations are found when the absolute indoor air humidity is above 7 g/kg (45% relative humidity at 20 degrees C). Consequently, ventilation by air-conditioning systems is being developed as a means of control. A number of other aspects of the domestic environment are also being manipulated in an integrated approach to render the habitat less suitable for mites. The potential exists for developing models for house-dust mite populations, environmental characteristics, and the effects of various approaches to control.

  4. Factors influencing the life cycle burdens of the recovery of energy from residual municipal waste.

    Science.gov (United States)

    Burnley, Stephen; Coleman, Terry; Peirce, Adam

    2015-05-01

    A life cycle assessment was carried out to assess a selection of the factors influencing the environmental impacts and benefits of incinerating the fraction of municipal waste remaining after source-separation for reuse, recycling, composting or anaerobic digestion. The factors investigated were the extent of any metal and aggregate recovery from the bottom ash, the thermal efficiency of the process, and the conventional fuel for electricity generation displaced by the power generated. The results demonstrate that incineration has significant advantages over landfill with lower impacts from climate change, resource depletion, acidification, eutrophication human toxicity and aquatic ecotoxicity. To maximise the benefits of energy recovery, metals, particularly aluminium, should be reclaimed from the residual bottom ash and the energy recovery stage of the process should be as efficient as possible. The overall environmental benefits/burdens of energy from waste also strongly depend on the source of the power displaced by the energy from waste, with coal giving the greatest benefits and combined cycle turbines fuelled by natural gas the lowest of those considered. Regardless of the conventional power displaced incineration presents a lower environmental burden than landfill. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Characterization factors for global warming in life cycle assessment based on damages to humans and ecosystems.

    Science.gov (United States)

    De Schryver, An M; Brakkee, Karin W; Goedkoop, Mark J; Huijbregts, Mark A J

    2009-03-15

    Human and ecosystem health damage due to greenhouse gas (GHG) emissions is generally poorly quantified in the life cycle assessment of products, preventing an integrated comparison of the importance of GHGs with other stressor types, such as ozone depletion and acidifying emissions. In this study, we derived new characterization factors for 63 GHGs that quantify the impact of an emission change on human and ecosystem health damage. For human health damage, the Disability Adjusted Life Years (DALYs) per unit emission related to malaria, diarrhea, malnutrition, drowning, and cardiovascular diseases were quantified. For ecosystem health damage, the Potentially Disappeared Fraction (PDF) over space and time of various species groups, including plants, butterflies, birds, and mammals, per unit emission was calculated. The influence of value choices in the modeling procedure was analyzed by defining three coherent scenarios, based on Cultural theory perspectives. It was found that the characterization factor for human health damage by carbon dioxide (CO2) ranges from 1.1 x 10(-2) to 1.8 x 10(+1) DALY per kton of emission, while the characterization factor for ecosystem damage by CO2 ranges from 5.4 x 10(-2) to 1.2 x 10(+1) disappeared fraction of species over space and time ((km2 x year)/kton), depending on the scenario chosen. The characterization factor of a GHG can change up to 4 orders of magnitude, depending on the scenario. The scenario-specific differences are mainly explained by the choice for a specific time horizon and stresses the importance of dealing with value choices in the life cycle impact assessment of GHG emissions.

  6. Role of insulin-like growth factor-1 (IGF-1) in regulating cell cycle progression

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Qi-lin; Yang, Tian-lun [Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, Hunan (China); Yin, Ji-ye [Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan (China); Peng, Zhen-yu [Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, Hunan (China); Yu, Min [Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan (China); Liu, Zhao-qian, E-mail: liuzhaoqian63@126.com [Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan (China); Chen, Fang-ping, E-mail: xychenfp@public.cs.hn.Cn [Department of Haematology, Xiangya Hospital, Central South University, Changsha 410008, Hunan (China)

    2009-11-06

    Aims: Insulin-like growth factor-1 (IGF-1) is a polypeptide protein hormone, similar in molecular structure to insulin, which plays an important role in cell migration, cell cycle progression, cell survival and proliferation. In this study, we investigated the possible mechanisms of IGF-1 mediated cell cycle redistribution and apoptosis of vascular endothelial cells. Method: Human umbilical vein endothelial cells (HUVECs) were pretreated with 0.1, 0.5, or 2.5 {mu}g/mL of IGF-1 for 30 min before the addition of Ang II. Cell cycle redistribution and apoptosis were examined by flow cytometry. Expression of Ang II type 1 (AT{sub 1}) mRNA and cyclin E protein were determined by RT-PCR and Western blot, respectively. Results: Ang II (1 {mu}mol/L) induced HUVECs arrested at G{sub 0}/G{sub 1}, enhanced the expression level of AT{sub 1} mRNA in a time-dependent manner, reduced the enzymatic activity of nitric oxide synthase (NOS) and nitric oxide (NO) content as well as the expression level of cyclin E protein. However, IGF-1 enhanced NOS activity, NO content, and the expression level of cyclin E protein, and reduced the expression level of AT{sub 1} mRNA. L-NAME significantly counteracted these effects of IGF-1. Conclusions: Our data suggests that IGF-1 can reverse vascular endothelial cells arrested at G{sub 0}/G{sub 1} and apoptosis induced by Ang II, which might be mediated via a NOS-NO signaling pathway and is likely associated with the expression levels of AT1 mRNA and cyclin E proteins.

  7. Role of insulin-like growth factor-1 (IGF-1) in regulating cell cycle progression

    International Nuclear Information System (INIS)

    Ma, Qi-lin; Yang, Tian-lun; Yin, Ji-ye; Peng, Zhen-yu; Yu, Min; Liu, Zhao-qian; Chen, Fang-ping

    2009-01-01

    Aims: Insulin-like growth factor-1 (IGF-1) is a polypeptide protein hormone, similar in molecular structure to insulin, which plays an important role in cell migration, cell cycle progression, cell survival and proliferation. In this study, we investigated the possible mechanisms of IGF-1 mediated cell cycle redistribution and apoptosis of vascular endothelial cells. Method: Human umbilical vein endothelial cells (HUVECs) were pretreated with 0.1, 0.5, or 2.5 μg/mL of IGF-1 for 30 min before the addition of Ang II. Cell cycle redistribution and apoptosis were examined by flow cytometry. Expression of Ang II type 1 (AT 1 ) mRNA and cyclin E protein were determined by RT-PCR and Western blot, respectively. Results: Ang II (1 μmol/L) induced HUVECs arrested at G 0 /G 1 , enhanced the expression level of AT 1 mRNA in a time-dependent manner, reduced the enzymatic activity of nitric oxide synthase (NOS) and nitric oxide (NO) content as well as the expression level of cyclin E protein. However, IGF-1 enhanced NOS activity, NO content, and the expression level of cyclin E protein, and reduced the expression level of AT 1 mRNA. L-NAME significantly counteracted these effects of IGF-1. Conclusions: Our data suggests that IGF-1 can reverse vascular endothelial cells arrested at G 0 /G 1 and apoptosis induced by Ang II, which might be mediated via a NOS-NO signaling pathway and is likely associated with the expression levels of AT1 mRNA and cyclin E proteins.

  8. Nanotoxicity and Life Cycle Assessment: First attempt towards the determination of characterization factors for carbon nanotubes

    Science.gov (United States)

    Rodriguez-Garcia, Gonzalo; Zimmermann, Benedikt; Weil, Marcel

    2014-08-01

    Carbon materials, whether at macro, micro or at nanoscale, play an important role in the battery industry, as they can be used as electrodes, electrode enhancers, bipolar separators, or current collectors. When conducting a Life Cycle Assessment (LCA) of novel batteries manufacturing processes, we also need to consider the fate of potentially emitted carbon based nanomaterials. However, the knowledge generated in the last decade regarding the behavior of such materials in the environment and its toxicological effects has yet to be included in the Life Cycle Impact Assessment (LCIA) methodologies. Conventional databases of chemical products (e.g. ECHA, ECOTOX) offer little information regarding engineered nanomaterials (ENM). It is thus necessary to go one step further and compile physicochemical and toxicological data directly from scientific literature. Such studies do not only differ in their results, but also in their methodologies, and several calls have been made towards a more consistent approach that would allow us model the fate of ENM in the environment as well as their potentially harmful effects. Trying to overcome these limitations we have developed a tool based on Microsoft Excel® combining several methods for the estimation of physicochemical properties of carbon nanotubes (CNT). The information generated with this tool is combined with degradation rates and toxicological data consistent with the methods followed by the USEtox methodology. Thus, it is possible to calculate the characterization factors of CNTs and integrate them as a first proxy in future LCA of products including these ENM.

  9. Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression.

    Science.gov (United States)

    Landry, Benjamin D; Mapa, Claudine E; Arsenault, Heather E; Poti, Kristin E; Benanti, Jennifer A

    2014-05-02

    To maintain genome stability, regulators of chromosome segregation must be expressed in coordination with mitotic events. Expression of these late cell cycle genes is regulated by cyclin-dependent kinase (Cdk1), which phosphorylates a network of conserved transcription factors (TFs). However, the effects of Cdk1 phosphorylation on many key TFs are not known. We find that elimination of Cdk1-mediated phosphorylation of four S-phase TFs decreases expression of many late cell cycle genes, delays mitotic progression, and reduces fitness in budding yeast. Blocking phosphorylation impairs degradation of all four TFs. Consequently, phosphorylation-deficient mutants of the repressors Yox1 and Yhp1 exhibit increased promoter occupancy and decreased expression of their target genes. Interestingly, although phosphorylation of the transcriptional activator Hcm1 on its N-terminus promotes its degradation, phosphorylation on its C-terminus is required for its activity, indicating that Cdk1 both activates and inhibits a single TF. We conclude that Cdk1 promotes gene expression by both activating transcriptional activators and inactivating transcriptional repressors. Furthermore, our data suggest that coordinated regulation of the TF network by Cdk1 is necessary for faithful cell division.

  10. Nanotoxicity and Life Cycle Assessment: First attempt towards the determination of characterization factors for carbon nanotubes

    International Nuclear Information System (INIS)

    Rodriguez-Garcia, Gonzalo; Weil, Marcel; Zimmermann, Benedikt

    2014-01-01

    Carbon materials, whether at macro, micro or at nanoscale, play an important role in the battery industry, as they can be used as electrodes, electrode enhancers, bipolar separators, or current collectors. When conducting a Life Cycle Assessment (LCA) of novel batteries manufacturing processes, we also need to consider the fate of potentially emitted carbon based nanomaterials. However, the knowledge generated in the last decade regarding the behavior of such materials in the environment and its toxicological effects has yet to be included in the Life Cycle Impact Assessment (LCIA) methodologies. Conventional databases of chemical products (e.g. ECHA, ECOTOX) offer little information regarding engineered nanomaterials (ENM). It is thus necessary to go one step further and compile physicochemical and toxicological data directly from scientific literature. Such studies do not only differ in their results, but also in their methodologies, and several calls have been made towards a more consistent approach that would allow us model the fate of ENM in the environment as well as their potentially harmful effects. Trying to overcome these limitations we have developed a tool based on Microsoft Excel ® combining several methods for the estimation of physicochemical properties of carbon nanotubes (CNT). The information generated with this tool is combined with degradation rates and toxicological data consistent with the methods followed by the USEtox methodology. Thus, it is possible to calculate the characterization factors of CNTs and integrate them as a first proxy in future LCA of products including these ENM

  11. Resources changes: a key factor in a new uranium production economic cycle

    International Nuclear Information System (INIS)

    Capus, G.; Caumartin, P.

    1996-01-01

    Since the end of 1994, a change has been underway in the uranium market. As usual in such cases, surprise and disbelief first dominated, but the market actors have been adjusting quickly to what now appears to be a return to primary production as the predominant factor in uranium supply. It is a matter of fact that the fundamentals will determine the course of the uranium market, as with other cyclical commodity markets. Comparing 1995 with 1975, a time of rocketing prices and production, and forecasting another cycle with similar characteristics to the last one is tempting, but illusory. However, examining the relative conditions prevailing at these times provides keys that may be helpful in understanding future developments. (author)

  12. Tcf3 and cell cycle factors contribute to butyrate resistance in colorectal cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Chiaro, Christopher, E-mail: cchiaro@tcmedc.org [Department of Basic Sciences, The Commonwealth Medical College, 525 Pine Street, Scranton, PA 18509 (United States); Lazarova, Darina L., E-mail: dlazarova@tcmedc.org [Department of Basic Sciences, The Commonwealth Medical College, 525 Pine Street, Scranton, PA 18509 (United States); Bordonaro, Michael, E-mail: mbordonaro@tcmedc.org [Department of Basic Sciences, The Commonwealth Medical College, 525 Pine Street, Scranton, PA 18509 (United States)

    2012-11-09

    Highlights: Black-Right-Pointing-Pointer We investigate mechanisms responsible for butyrate resistance in colon cancer cells. Black-Right-Pointing-Pointer Tcf3 modulates butyrate's effects on Wnt activity and cell growth in resistant cells. Black-Right-Pointing-Pointer Tcf3 modulation of butyrate's effects differ by cell context. Black-Right-Pointing-Pointer Cell cycle factors are overexpressed in the resistant cells. Black-Right-Pointing-Pointer Reversal of altered gene expression can enhance the anti-cancer effects of butyrate. -- Abstract: Butyrate, a fermentation product of dietary fiber, inhibits clonal growth in colorectal cancer (CRC) cells dependent upon the fold induction of Wnt activity. We have developed a CRC cell line (HCT-R) that, unlike its parental cell line, HCT-116, does not respond to butyrate exposure with hyperactivation of Wnt signaling and suppressed clonal growth. PCR array analyses revealed Wnt pathway-related genes, the expression of which differs between butyrate-sensitive HCT-116 CRC cells and their butyrate-resistant HCT-R cell counterparts. We identified overexpression of Tcf3 as being partially responsible for the butyrate-resistant phenotype, as this DNA-binding protein suppresses the hyperinduction of Wnt activity by butyrate. Consequently, Tcf3 knockdown in HCT-R cells restores their sensitivity to the effects of butyrate on Wnt activity and clonal cell growth. Interestingly, the effects of overexpressed Tcf3 differ between HCT-116 and HCT-R cells; thus, in HCT-116 cells Tcf3 suppresses proliferation without rendering the cells resistant to butyrate. In HCT-R cells, however, the overexpression of Tcf3 inhibits Wnt activity, and the cells are still able to proliferate due to the higher expression levels of cell cycle factors, particularly those driving the G{sub 1} to S transition. Knowledge of the molecular mechanisms determining the variable sensitivity of CRC cells to butyrate may assist in developing approaches that

  13. Tcf3 and cell cycle factors contribute to butyrate resistance in colorectal cancer cells

    International Nuclear Information System (INIS)

    Chiaro, Christopher; Lazarova, Darina L.; Bordonaro, Michael

    2012-01-01

    Highlights: ► We investigate mechanisms responsible for butyrate resistance in colon cancer cells. ► Tcf3 modulates butyrate’s effects on Wnt activity and cell growth in resistant cells. ► Tcf3 modulation of butyrate’s effects differ by cell context. ► Cell cycle factors are overexpressed in the resistant cells. ► Reversal of altered gene expression can enhance the anti-cancer effects of butyrate. -- Abstract: Butyrate, a fermentation product of dietary fiber, inhibits clonal growth in colorectal cancer (CRC) cells dependent upon the fold induction of Wnt activity. We have developed a CRC cell line (HCT-R) that, unlike its parental cell line, HCT-116, does not respond to butyrate exposure with hyperactivation of Wnt signaling and suppressed clonal growth. PCR array analyses revealed Wnt pathway-related genes, the expression of which differs between butyrate-sensitive HCT-116 CRC cells and their butyrate-resistant HCT-R cell counterparts. We identified overexpression of Tcf3 as being partially responsible for the butyrate-resistant phenotype, as this DNA-binding protein suppresses the hyperinduction of Wnt activity by butyrate. Consequently, Tcf3 knockdown in HCT-R cells restores their sensitivity to the effects of butyrate on Wnt activity and clonal cell growth. Interestingly, the effects of overexpressed Tcf3 differ between HCT-116 and HCT-R cells; thus, in HCT-116 cells Tcf3 suppresses proliferation without rendering the cells resistant to butyrate. In HCT-R cells, however, the overexpression of Tcf3 inhibits Wnt activity, and the cells are still able to proliferate due to the higher expression levels of cell cycle factors, particularly those driving the G 1 to S transition. Knowledge of the molecular mechanisms determining the variable sensitivity of CRC cells to butyrate may assist in developing approaches that prevent or reverse butyrate resistance.

  14. Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif.

    Directory of Open Access Journals (Sweden)

    Mei Ying Ng

    Full Text Available Cycle inhibiting factors (Cifs are virulence proteins secreted by the type III secretion system of some Gram-negative pathogenic bacteria including Burkholderia pseudomallei. Cif is known to function to deamidate Nedd8, leading to inhibition of Cullin E3 ubiquitin ligases (CRL and consequently induction of cell cycle arrest. Here we show that Cif can function as a potent activator of MAPK/ERK signaling without significant activation of other signaling pathways downstream of receptor tyrosine kinases. Importantly, we found that the ability of Cif to activate ERK is dependent on its deamidase activity, but independent of Cullin E3 ligase inhibition. This suggests that apart from Nedd8, other cellular targets of Cif-dependent deamidation exist. We provide evidence that the mechanism involved in Cif-mediated ERK activation is dependent on recruitment of the Grb2-SOS1 complex to the plasma membrane. Further investigation revealed that Cif appears to modify the phosphorylation status of SOS1 in a region containing the CDC25-H and proline-rich domains. It is known that prolonged Cullin E3 ligase inhibition leads to cellular apoptosis. Therefore, we hypothesize that ERK activation is an important mechanism to counter the pro-apoptotic effects of Cif. Indeed, we show that Cif dependent ERK activation promotes phosphorylation of the proapoptotic protein Bim, thereby potentially conferring a pro-survival signal. In summary, we identified a novel deamidation-dependent mechanism of action of the B. pseudomallei virulence factor Cif/CHBP to activate MAPK/ERK signaling. Our study demonstrates that bacterial proteins such as Cif can serve as useful molecular tools to uncover novel aspects of mammalian signaling pathways.

  15. Overexpression of transcription factor Sp1 leads to gene expression perturbations and cell cycle inhibition.

    Directory of Open Access Journals (Sweden)

    Emmanuelle Deniaud

    Full Text Available BACKGROUND: The ubiquitous transcription factor Sp1 regulates the expression of a vast number of genes involved in many cellular functions ranging from differentiation to proliferation and apoptosis. Sp1 expression levels show a dramatic increase during transformation and this could play a critical role for tumour development or maintenance. Although Sp1 deregulation might be beneficial for tumour cells, its overexpression induces apoptosis of untransformed cells. Here we further characterised the functional and transcriptional responses of untransformed cells following Sp1 overexpression. METHODOLOGY AND PRINCIPAL FINDINGS: We made use of wild-type and DNA-binding-deficient Sp1 to demonstrate that the induction of apoptosis by Sp1 is dependent on its capacity to bind DNA. Genome-wide expression profiling identified genes involved in cancer, cell death and cell cycle as being enriched among differentially expressed genes following Sp1 overexpression. In silico search to determine the presence of Sp1 binding sites in the promoter region of modulated genes was conducted. Genes that contained Sp1 binding sites in their promoters were enriched among down-regulated genes. The endogenous sp1 gene is one of the most down-regulated suggesting a negative feedback loop induced by overexpressed Sp1. In contrast, genes containing Sp1 binding sites in their promoters were not enriched among up-regulated genes. These results suggest that the transcriptional response involves both direct Sp1-driven transcription and indirect mechanisms. Finally, we show that Sp1 overexpression led to a modified expression of G1/S transition regulatory genes such as the down-regulation of cyclin D2 and the up-regulation of cyclin G2 and cdkn2c/p18 expression. The biological significance of these modifications was confirmed by showing that the cells accumulated in the G1 phase of the cell cycle before the onset of apoptosis. CONCLUSION: This study shows that the binding to DNA

  16. RNA interference regulates the cell cycle checkpoint through the RNA export factor, Ptr1, in fission yeast

    Energy Technology Data Exchange (ETDEWEB)

    Iida, Tetsushi, E-mail: tiida@nig.ac.jp [Division of Cytogenetics, National Institute of Genetics, Mishima, 1111 Yata, Mishima 411-8540 (Japan); The Graduate University for Advanced Studies, Sokendai, Mishima, 1111 Yata, Mishima 411-8540 (Japan); Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), 4-1-8, Honcho, Kawaguchi-shi, Saitama 332-0012 (Japan); Iida, Naoko [Division of Mutagenesis, National Institute of Genetics, Mishima, 1111 Yata, Mishima 411-8540 (Japan); Tsutsui, Yasuhiro [Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuda-cho, Midori-ku, Yokohama 226-8501 (Japan); Yamao, Fumiaki [Division of Mutagenesis, National Institute of Genetics, Mishima, 1111 Yata, Mishima 411-8540 (Japan); The Graduate University for Advanced Studies, Sokendai, Mishima, 1111 Yata, Mishima 411-8540 (Japan); Kobayashi, Takehiko [Division of Cytogenetics, National Institute of Genetics, Mishima, 1111 Yata, Mishima 411-8540 (Japan); The Graduate University for Advanced Studies, Sokendai, Mishima, 1111 Yata, Mishima 411-8540 (Japan)

    2012-10-12

    Highlights: Black-Right-Pointing-Pointer RNAi is linked to the cell cycle checkpoint in fission yeast. Black-Right-Pointing-Pointer Ptr1 co-purifies with Ago1. Black-Right-Pointing-Pointer The ptr1-1 mutation impairs the checkpoint but does not affect gene silencing. Black-Right-Pointing-Pointer ago1{sup +} and ptr1{sup +} regulate the cell cycle checkpoint via the same pathway. Black-Right-Pointing-Pointer Mutations in ago1{sup +} and ptr1{sup +} lead to the nuclear accumulation of poly(A){sup +} RNAs. -- Abstract: Ago1, an effector protein of RNA interference (RNAi), regulates heterochromatin silencing and cell cycle arrest in fission yeast. However, the mechanism by which Ago1 controls cell cycle checkpoint following hydroxyurea (HU) treatment has not been elucidated. In this study, we show that Ago1 and other RNAi factors control cell cycle checkpoint following HU treatment via a mechanism independent of silencing. While silencing requires dcr1{sup +}, the overexpression of ago1{sup +} alleviated the cell cycle defect in dcr1{Delta}. Ago1 interacted with the mRNA export factor, Ptr1. The ptr1-1 mutation impaired cell cycle checkpoint but gene silencing was unaffected. Genetic analysis revealed that the regulation of cell cycle checkpoint by ago1{sup +} is dependent on ptr1{sup +}. Nuclear accumulation of poly(A){sup +} RNAs was detected in mutants of ago1{sup +} and ptr1{sup +}, suggesting there is a functional link between the cell cycle checkpoint and RNAi-mediated RNA quality control.

  17. Combined factors effect of menstrual cycle and background noise on visual inspection task performance: a simulation-based task.

    Science.gov (United States)

    Wijayanto, Titis; Tochihara, Yutaka; Wijaya, Andi R; Hermawati, Setia

    2009-11-01

    It is well known that women are physiologically and psychologically influenced by the menstrual cycle. In addition, the presence of background noise may affect task performance. So far, it has proven difficult to describe how the menstrual cycle and background noise affect task performance; some researchers have found an increment of performance during menstruation or during the presence of noise, others found performance deterioration, while other still have reported no dominant effect either of the menstrual cycle in performance or of the presence of noise. However, no study to date has investigated the combinational effect between the menstrual cycle and the presence of background noise in task performance. Therefore, the purpose of this study was to examine the combined factor effect of menstrual cycle and background noise on visual inspection task performance indices by Signal Detection Theory (SDT) metrics: sensitivity index (d') and response criteria index (beta). For this purpose, ten healthy female students (21.5+/-1.08 years) with a regular menstrual cycle participated in this study. A VDT-based visual inspection task was used for the experiment in 3x2 factorial designs. Two factors, menstrual phase, pre-menstruation (PMS), menstruation (M), and post-menstruation (PM) and background noise, with 80 dB(A) background noise and without noise, were analyzed as the main factors in this study. The results concluded that the sensitivity index (d') of SDT was affected in all the menstrual cycle conditions (pbackground noise (pbackground noise was found in this study. On the other hand, no significant effect was observed in the subject's tendency in visual inspection, shown by beta along the menstrual cycle and the presence of background noise. According to the response criteria for each individual subject, the presence of noise affected the tendency of some subjects in detecting the object and making decision during the visual inspection task.

  18. Business Cycle Dynamics in the Euro Area: A Factor-SVAR Approach

    OpenAIRE

    Atilim Seymen

    2009-01-01

    The study investigates the business cycle dynamics in the euro area using an empirical framework which comprises common global and euro area shocks as well as allows bilateral spillovers of country-specific shocks across the member economies. Three core questions lie at the heart of the analysis: (i) To what extent are the business cycles of the euro area countries driven by common and spillover shocks? (ii) What are the extent and sources of business cycle heterogeneity in the euro area? (ii...

  19. Factors determining the UK's back-end nuclear fuel cycle strategy and future nuclear systems

    International Nuclear Information System (INIS)

    Dunn, M.J.; Ainsworth, Z.E.

    2002-01-01

    Nuclear generating capacity in the UK is static with no units currently under construction. The AGRs and the UK's only PWR, Sizewell B, are operated by British Energy Generation Ltd (BEGL) and British Energy Generation (UK) Ltd (BEG(UK)L), who are subsidiaries of British Energy plc (BE) which was privatised in July 1996. Ownership of the Magnox stations, which were excluded from this privatisation, has now been transferred to BNFL.Government policy on spent fuel management in the UK is that it is for the owners of the spent fuel to decide on the appropriate spent fuel management options, based on their own commercial judgement, subject to meeting the necessary regulatory requirements. The main factors which have predominantly determined UK utility decisions on spent fuel management, to date, have been based on the technical considerations of the spent fuel characteristics, economic attractiveness of the options and at reactor site spent fuel storage capacities. To date, reprocessing has been the dominant form of spent fuel treatment in the UK. Spent fuel storage facilities consist of a mixture of at-reactor stores and large, centralised ponds associated with the reprocessing activities which take place at the Sellafield site. BEGL and BEG(UK)L have contracts for the lifetime arisings of AGR fuel which allow for all AGR spent fuel to be sent to Sellafield for reprocessing or long-term storage. The prompt reprocessing of all Magnox fuel will continue, and spent PWR fuel will continue to be stored at the reactor site in the short to medium term. It is likely that a combination of factors, which are discussed later in this paper, will continue to affect back-end nuclear fuel cycle strategy and future nuclear systems. (author)

  20. Nitrogen attenuation of terrestrial carbon cycle response to global environmental factors

    Science.gov (United States)

    Atul Jain; Xiaojuan Yang; Haroon Kheshgi; A. David McGuire; Wilfred Post; David. Kicklighter

    2009-01-01

    Nitrogen cycle dynamics have the capacity to attenuate the magnitude of global terrestrial carbon sinks and sources driven by CO2 fertilization and changes in climate. In this study, two versions of the terrestrial carbon and nitrogen cycle components of the Integrated Science Assessment Model (ISAM) are used to evaluate how variation in nitrogen...

  1. Development of real-world driving cycles and estimation of emission factors for in-use light-duty gasoline vehicles in urban areas.

    Science.gov (United States)

    Hwa, Mei-Yin; Yu, Tai-Yi

    2014-07-01

    This investigation adopts vehicle tracking manner to establish real-world driving patterns and estimates emission factors with dynamometers with 23 traffic-driving variables for 384 in-use light-duty passenger vehicles during non-rush hour. Adequate numbers of driving variables were decided with factor analysis and cluster analysis. The dynamometer tests were performed on FTP75 cycle and five local driving cycles derived from real-world speed profiles. Results presented that local driving cycles and FTP75 cycle were completely different in driving characteristic parameters of typical driving cycles and emission factors. The highest values of emission factor ratios of local driving cycle and FTP75 cycle for CO, NMHC, NO x , CH4, and CO2 were 1.38, 1.65, 1.58, 1.39, and 1.14, respectively.

  2. Establishment and prioritization of relevant factors to the safety of fuel cycle facilities non reactor through dynamics archetypes evaluation

    International Nuclear Information System (INIS)

    Sousa, Anna Leticia Barbosa de

    2012-01-01

    The present work aims to establish and prioritize factors that are important to the safety of nuclear fuel cycle facilities in order to model, analyze and design safety as a physical system, employing systemic models in an innovative way. This work takes into consideration the fact that models that use adaptations of methodologies for nuclear reactors will not properly work due to the specificities of fuel cycle facilities. Based on the fundamentals of the theory of systems, the four levels of system thinking, and the relationship of eight socio technical factors, a mental model has been developed for safety management in the nuclear fuel cycle context. From this conceptual model, safety archetypes were constructed in order to identify and highlight the processes of change and decision making that allow the system to migrate to a state of loss of safety. After that, stock and flow diagrams were created so that their behavior could be assessed by the system's dynamics. The results from the analysis using the model that simulates the dynamic behavior of the variables (socio technical factors) indicated, as expected, that the system's dynamics proved to be an appropriate and efficient tool for modeling fuel cycle safety as an emergent property. (author)

  3. Effect of Air Pollution on Menstrual Cycle Length-A Prognostic Factor of Women's Reproductive Health.

    Science.gov (United States)

    Merklinger-Gruchala, Anna; Jasienska, Grazyna; Kapiszewska, Maria

    2017-07-20

    Air pollution can influence women's reproductive health, specifically menstrual cycle characteristics, oocyte quality, and risk of miscarriage. The aim of the study was to assess whether air pollution can affect the length of the overall menstrual cycle and the length of its phases (follicular and luteal). Municipal ecological monitoring data was used to assess the air pollution exposure during the monitored menstrual cycle of each of 133 woman of reproductive age. Principal component analyses were used to group pollutants (PM 10 , SO₂, CO, and NO x ) to represent a source-related mixture. PM 10 and SO₂ assessed separately negatively affected the length of the luteal phase after standardization (b = -0.02; p = 0.03; b = -0.06; p = 0.02, respectively). Representing a fossil fuel combustion emission, they were also associated with luteal phase shortening (b = -0.32; p = 0.02). These pollutants did not affect the follicular phase length and overall cycle length, neither in single- nor in multi-pollutant models. CO and NO x assessed either separately or together as a traffic emission were not associated with overall cycle length or the length of cycle phases. Luteal phase shortening, a possible manifestation of luteal phase deficiency, can result from fossil fuel combustion. This suggests that air pollution may contribute to fertility problems in women.

  4. The low cycle fatigue factor in the construction of sodium-cooled fast reactors

    International Nuclear Information System (INIS)

    Petrequin, Pierre; Mottot, Michel; Valibus, Louis; Grattier, Georges

    1976-01-01

    The working conditions of fast neutron reactors are such that it is essential to know the resistance of the component steels to low cycle fatigue. The behavior of Z2CND17-13 type austenitic stainless steels and of welds was studied in three laboratories. The steels offer an excellent resistance to low cycle fatigue, in keeping with their good ductility and very strong aptitude for cyclic strain hardening. Increasing the testing temperature from 20 to 600 deg C reduces the resistance to some extent (about an order of magnitude on the number of cycles to failure). Steels possessing improved mechanical properties without loss of ductility show greater fatigue resistance. Welds characterized by an austenitic ferritic structure and a slightly cold-hardened state are less ductile than laminated steels. Their resistance to low cycle fatigue is lower at strong deformations. At high temperature (600 deg C) a reduced test frequency or a pause at each cycle leads to a considerable drop in the number of cycles to failure and the appearance of intergranular cracking [fr

  5. Safety assessment of human and organizational factors in French fuel cycle facilities

    International Nuclear Information System (INIS)

    Menuet, Lise; Beauquier, Sophie

    2013-01-01

    According to the French law, each nuclear facility has to provide a safety demonstration every ten years. The assessment of this demonstration supports the decision of the French Safety Authority regarding the authorisation of operating for the ten years to come. In addition, transversal topics, which are linked with safety performance, such as safety management, management of competencies, maintenance's policy are periodically evaluated. One aspect of these assessments relates to Human and Organizational Factors (HOF) and their contribution to safety. Our communication will describe the assessment of the HOF-related part, performed by the Institute for Radioprotection and Nuclear Safety Institute (IRSN) the Technical Support Organisation of the French Safety Authority). It will focus on the methodological framework, the tools which are developed and used for assessing the integration of HOF in safety demonstration, and the main difficulties of this kind of assessment. Each situation will be illustrated by concrete examples coming from safety assessments concerning fuel cycle's plants: Areva's plants dedicated to uranium conversion, uranium enrichment, fuel manufacturing, spent fuel reprocessing, treatment facilities and CEA's laboratories dedicated to research and development and to interim spent fuel storage. The methodological framework for assessing HOF currently implements three main steps which will be precisely described: - checking that the nuclear plant has made an exhaustive analysis of the risks linked with HOF. Regarding to HOF, the Licensee safety demonstration is based on the description of the main human activities which are considered as hazardous regarding safety. These activities are accomplished with a human contribution and they require a safe realisation. - assessing the human, organisational and technical barriers that the nuclear plant have planed in order to make the operations safe, to avoid, prevent or detect an

  6. Analysis of factors affecting the implementation of back-end nuclear fuel cycle policy in Korea

    International Nuclear Information System (INIS)

    Choi, Yung Myung; Yang, Maeng Ho; Kim, Hyun Joon; Chung, Hwan Sam; Oh, Keun Bae; Lee, Byung OoK; Ko, Han Suk; Song, Ki Dong; Lee, Man Ki; Moon, Ki Hwan; Lee, Han Myung

    1994-01-01

    In this study, the back-end nuclear fuel cycle acceptability is surveyed and analyzed in the following three aspects. To begin with, the future political situation and energy-environmental issues are analyzed as part of the socio-economic aspect. Secondly, the domestic situation of nuclear industries and the fuel cycle policy of foreign countries are surveyed as the technical aspect. Finally, NPT, IAEA safeguards and nuclear export control regimes are analyzed as the institutional aspect. The unification period of South and North Korea also will greatly affect the implementation of back-end fuel cycle policy, and public attitudes will affect the acquisition of site, construction, and operation of nuclear facilities. An effort to release international restrictions on the back-end fuel cycle is also required to accelerate the implementation of the policy. In this regard, the back-end fuel cycle policy should be clear-cut to avoid misunderstanding with respect to nuclear proliferation. Importantly, agreements with foreign countries should be amended at a mutual equivalent level. (Author) 30 refs., 5 figs., 25 tabs

  7. Analysis of factors affecting the implementation of back-end nuclear fuel cycle policy in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Yung Myung; Yang, Maeng Ho; Kim, Hyun Joon; Chung, Hwan Sam; Oh, Keun Bae; Lee, Byung OoK; Ko, Han Suk; Song, Ki Dong; Lee, Man Ki; Moon, Ki Hwan; Lee, Han Myung [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1994-01-01

    In this study, the back-end nuclear fuel cycle acceptability is surveyed and analyzed in the following three aspects. To begin with, the future political situation and energy-environmental issues are analyzed as part of the socio-economic aspect. Secondly, the domestic situation of nuclear industries and the fuel cycle policy of foreign countries are surveyed as the technical aspect. Finally, NPT, IAEA safeguards and nuclear export control regimes are analyzed as the institutional aspect. The unification period of South and North Korea also will greatly affect the implementation of back-end fuel cycle policy, and public attitudes will affect the acquisition of site, construction, and operation of nuclear facilities. An effort to release international restrictions on the back-end fuel cycle is also required to accelerate the implementation of the policy. In this regard, the back-end fuel cycle policy should be clear-cut to avoid misunderstanding with respect to nuclear proliferation. Importantly, agreements with foreign countries should be amended at a mutual equivalent level. (Author) 30 refs., 5 figs., 25 tabs.

  8. The Role of Infertility Etiology in Success Rate of Intrauterine Insemination Cycles: An Evaluation of Predictive Factors for Pregnancy Rate

    Science.gov (United States)

    Ashrafi, Mahnaz; Rashidi, Mandana; Ghasemi, Afsaneh; Arabipoor, Arezoo; Daghighi, Sara; Pourasghari, Parisa; Zolfaghari, Zahra

    2013-01-01

    Background: The objective of this study was to identify the prognostic factors that influence the outcome of ovarian stimulation with intrauterine insemination (IUI) cycles in couples with different infertility etiology. Materials and Methods: This retrospective study was performed in data of 1348 IUI cycles with ovarian stimulation by clomiphene citrate (CC) and/or gonadotropins in 632 women with five different infertility etiology subgroups at Akbarabbadi Hospital, Tehran, Iran. Results: The pregnancy rate (PR)/ cycle was highest (19.9%) among couples with unexplained infertility and lowest (10.6%) in couples with multiple factors infertility. In cases of unexplained infertility, the best PRs were seen after CC plus gonadotropins stimulation (26.3%) and with inseminated motile sperm count>30×106 (21.9%), but the tendency didn’t reach statistical significant. In the ovarian factor group, the best PRs were observed in women aged between 30 and 34 years (20.8%), with 2-3 preovulatory follicles (37.8%) and infertility duration between 1and 3 years (20.8%), while only infertility duration (p=0.03) and number of preovulatory follicles (p=0.01) were statistically significant. Multiple logistic regression analysis determined that number of preovulatory follicles (p=0.02), duration of infertility (p=0.015), age (p=0.019), infertility etiology (p=0.05) and stimulation regimen (p=0.01) were significant independent factors in order to predict overall clinical PR. Conclusion: The etiology of infertility is important to achieve remarkable IUI success. It is worth mentioning that within different etiologies of infertility, the demographic and cycles characteristics of couples did not show the same effect. Favorable variables for treatment success are as follows: age infertility ≤5 years and a cause of infertility except of multiple factors. PMID:24520471

  9. H4 histamine receptors mediate cell cycle arrest in growth factor-induced murine and human hematopoietic progenitor cells.

    Directory of Open Access Journals (Sweden)

    Anne-France Petit-Bertron

    Full Text Available The most recently characterized H4 histamine receptor (H4R is expressed preferentially in the bone marrow, raising the question of its role during hematopoiesis. Here we show that both murine and human progenitor cell populations express this receptor subtype on transcriptional and protein levels and respond to its agonists by reduced growth factor-induced cell cycle progression that leads to decreased myeloid, erythroid and lymphoid colony formation. H4R activation prevents the induction of cell cycle genes through a cAMP/PKA-dependent pathway that is not associated with apoptosis. It is mediated specifically through H4R signaling since gene silencing or treatment with selective antagonists restores normal cell cycle progression. The arrest of growth factor-induced G1/S transition protects murine and human progenitor cells from the toxicity of the cell cycle-dependent anticancer drug Ara-C in vitro and reduces aplasia in a murine model of chemotherapy. This first evidence for functional H4R expression in hematopoietic progenitors opens new therapeutic perspectives for alleviating hematotoxic side effects of antineoplastic drugs.

  10. Factors threatening the survival of independent financial advisers in their organisational life cycle: an exploratory study

    Directory of Open Access Journals (Sweden)

    Estelle van Tonder

    2011-06-01

    Full Text Available This study investigates various threats to the survival of independent financial advisers in their organisational life cycle.  Telephone interviews were conducted to gain more insight into the demographic data of the respondents and to attempt to group them into life cycle stages.  Personal interviews were conducted to investigate the respondents' problems.  The contribution of this study is twofold:  First, general life cycle stages applicable to the businesses of independent financial advisers were determined.  Secondly, the study identified the important problems as well as those that ought to be consideration in the advisers' businesses.  The findings could be of assistance to independent financial advisers in analysing both their current business position and their planning for future requirements as the business develops from one stage to the next.

  11. Status of the natural and enriched uranium market: the basic economical factor for the development of the fuel cycle

    International Nuclear Information System (INIS)

    Nochev, T.

    1999-01-01

    Status of the Natural and Enriched Uranium Market - the Basic. Economical Factor for the Development of the Fuel Cycle An overview of the status of the natural and enriched uranium market has been performed and it offers a possibility to estimate the changes and tendencies, the knowledge of which is needed in negotiations about the fresh fuel. The simplified financial analysis presented here demonstrates the economical profitability of the storage of the spent fuel making now the allocations for the future reprocessing

  12. Critical factors affecting life cycle assessments of material choice for vehicle mass reduction

    Science.gov (United States)

    This review examines the use of life-cycle assessments (LCAs) to compare different lightweight materials being developed to improve light-duty vehicle fuel economy. Vehicle manufacturers are designing passenger cars and light-duty trucks using lighter weight materials and design ...

  13. The US Business Cycle, 1867-2006 : A Dynamic Factor Approach

    NARCIS (Netherlands)

    Ritschl, Albrecht; Sarferaz, Samad; Uebele, Martin

    We estimate a Stock/Watson index of economic activity to assess U.S. business cycle volatility since 1867. We replicate the Great Moderation of the 1980s and 1990s and find exceptionally low volatility also in the Golden Age of the 1960s. Postwar moderation relative to pre-1914 occurs under constant

  14. Occupational cycling is a risk factor for erectile dysfunction in east ...

    African Journals Online (AJOL)

    Logistic regression indicated that the odds of reporting Erectile Dysfunction were 9.1 (95% CI: 5.4-15.5) times higher in cyclists compared to noncyclists controls. Conclusion: In East Africa, occupational cycling is associated with lower International Index of Erectile Function scores and higher rates of Erectile Dysfunction.

  15. Functional interrelationship between TFII-I and E2F transcription factors at specific cell cycle gene loci.

    Science.gov (United States)

    Shen, Yong; Nar, Rukiye; Fan, Alex X; Aryan, Mahmoud; Hossain, Mir A; Gurumurthy, Aishwarya; Wassel, Paul C; Tang, Ming; Lu, Jianrong; Strouboulis, John; Bungert, Jörg

    2018-01-01

    Transcription factor TFII-I is a multifunctional protein implicated in the regulation of cell cycle and stress-response genes. Previous studies have shown that a subset of TFII-I associated genomic sites contained DNA-binding motifs for E2F family transcription factors. We analyzed the co-association of TFII-I and E2Fs in more detail using bioinformatics, chromatin immunoprecipitation, and co-immunoprecipitation experiments. The data show that TFII-I interacts with E2F transcription factors. Furthermore, TFII-I, E2F4, and E2F6 interact with DNA-regulatory elements of several genes implicated in the regulation of the cell cycle, including DNMT1, HDAC1, CDKN1C, and CDC27. Inhibition of TFII-I expression led to a decrease in gene expression and in the association of E2F4 and E2F6 with these gene loci in human erythroleukemia K562 cells. Finally, TFII-I deficiency reduced the proliferation of K562 cells and increased the sensitivity toward doxorubicin toxicity. The results uncover novel interactions between TFII-I and E2Fs and suggest that TFII-I mediates E2F function at specific cell cycle genes. © 2017 Wiley Periodicals, Inc.

  16. Radiation exposure of German aircraft crews under the impact of solar cycle 23 and airline business factors.

    Science.gov (United States)

    Frasch, Gerhard; Kammerer, Lothar; Karofsky, Ralf; Schlosser, Andrea; Stegemann, Ralf

    2014-12-01

    The exposure of German aircraft crews to cosmic radiation varies both with solar activity and operational factors of airline business. Data come from the German central dose registry and cover monthly exposures of up to 37,000 German aircraft crewmembers that were under official monitoring. During the years 2004 to 2009 of solar cycle 23 (i.e., in the decreasing phase of solar activity), the annual doses of German aircraft crews increased by an average of 20%. Decreasing solar activity allows more galactic radiation to reach the atmosphere, increasing high-altitude doses. The rise results mainly from the less effective protection from the solar wind but also from airline business factors. Both cockpit and cabin personnel differ in age-dependent professional and social status. This status determines substantially the annual effective dose: younger cabin personnel and the elder pilots generally receive higher annual doses than their counterparts. They also receive larger increases in their annual dose when the solar activity decreases. The doses under this combined influence of solar activity and airline business factors result in a maximum of exposure for German aircrews for this solar cycle. With the increasing solar activity of the current solar cycle 24, the doses are expected to decrease again.

  17. Development and review of Euro 5 passenger car emission factors based on experimental results over various driving cycles.

    Science.gov (United States)

    Fontaras, Georgios; Franco, Vicente; Dilara, Panagiota; Martini, Giorgio; Manfredi, Urbano

    2014-01-15

    The emissions of CO2 and regulated pollutants (NOx, HC, CO, PM) of thirteen Euro 5 compliant passenger cars (seven gasoline, six Diesel) were measured on a chassis dynamometer. The vehicles were driven repeatedly over the European type-approval driving cycle (NEDC) and the more dynamic WMTC and CADC driving cycles. Distance-specific emission factors were derived for each pollutant and sub-cycle, and these were subsequently compared to the corresponding emission factors provided by the reference European models used for vehicle emission inventory compilation (COPERT and HBEFA) and put in context with the applicable European emission limits. The measured emissions stayed below the legal emission limits when the type-approval cycle (NEDC) was used. Over the more dynamic cycles (considered more representative of real-world driving) the emissions were consistently higher but in most cases remained below the type-approval limit. The high NOx emissions of Diesel vehicles under real-world driving conditions remain the main cause for environmental concern regarding the emission profile of Euro 5 passenger cars. Measured emissions of NOx exceeded the type-approval limits (up to 5 times in extreme cases) and presented significantly increased average values (0.35 g/km for urban driving and 0.56 g/km for motorway driving). The comparison with the reference models showed good correlation in all cases, a positive finding considering the importance of these tools in emission monitoring and policy-making processes. © 2013. Published by Elsevier B.V. All rights reserved.

  18. Evaluation of von Willebrand factor during pregnancy, lactation and oestrous cycle in bitches affected and unaffected by von Willebrand disease.

    Science.gov (United States)

    Mattoso, C R S; Takahira, R K; Beier, S L; Araujo, J P; Corrente, J E

    2013-06-01

    Plasmatic concentrations of von Willebrand Factor (vWF) increase during pregnancy in humans and dogs; however the mechanism of such increase is still not well defined. The aims of this study were: (i) to evaluate changes in vWF concentration during pregnancy and during the subsequent oestrous cycle in bitches affected and unaffected by von Willebrand Disease (vWD); (ii) to correlate the vWF levels and cortisol levels in both groups. Seven vWD affected (GI) and nine unaffected (GII) bitches were used. The animals were assessed during pregnancy, parturition, lactation and non-gestational oestrous cycle in 11 moments (Pregnancy 1, Pregnancy 2, Parturition, Lactation 1, Lactation 2, Lactation 3, Anestrus, Proestrus, Oestrus, Diestrus 1, and Diestrus 2). The following tests were performed; measurement of von Willebrand factor antigen (vWF:Ag), albumin and cortisol. In both groups, vWF concentration remained stable during the non-gestational oestrous cycle, but increased during pregnancy, with the highest value observed at parturition. Increases of 70% and 124% in vWF were seen in GI and GII, respectively, compared to anestrus. No correlation was found between vWF and cortisol. Values of vWF:Ag changed during pregnancy, with a peak at parturition, both in vWD affected and unaffected animals. Values of vWF were not altered in the different phases of the oestrous cycle following pregnancy in both groups. Evaluation of vWF during pregnancy can cause false negative results for vWD, but assessment can be performed at any point in the oestrous cycle of non-pregnant bitches. © 2012 Blackwell Verlag GmbH.

  19. The change of radial power factor distribution due to RCCA insertion at the first cycle core of AP1000

    Science.gov (United States)

    Susilo, J.; Suparlina, L.; Deswandri; Sunaryo, G. R.

    2018-02-01

    The using of a computer program for the PWR type core neutronic design parameters analysis has been carried out in some previous studies. These studies included a computer code validation on the neutronic parameters data values resulted from measurements and benchmarking calculation. In this study, the AP1000 first cycle core radial power peaking factor validation and analysis were performed using CITATION module of the SRAC2006 computer code. The computer code has been also validated with a good result to the criticality values of VERA benchmark core. The AP1000 core power distribution calculation has been done in two-dimensional X-Y geometry through ¼ section modeling. The purpose of this research is to determine the accuracy of the SRAC2006 code, and also the safety performance of the AP1000 core first cycle operating. The core calculations were carried out with the several conditions, those are without Rod Cluster Control Assembly (RCCA), by insertion of a single RCCA (AO, M1, M2, MA, MB, MC, MD) and multiple insertion RCCA (MA + MB, MA + MB + MC, MA + MB + MC + MD, and MA + MB + MC + MD + M1). The maximum power factor of the fuel rods value in the fuel assembly assumedapproximately 1.406. The calculation results analysis showed that the 2-dimensional CITATION module of SRAC2006 code is accurate in AP1000 power distribution calculation without RCCA and with MA+MB RCCA insertion.The power peaking factor on the first operating cycle of the AP1000 core without RCCA, as well as with single and multiple RCCA are still below in the safety limit values (less then about 1.798). So in terms of thermal power generated by the fuel assembly, then it can be considered that the AP100 core at the first operating cycle is safe.

  20. A cell cycle role for the epigenetic factor CTCF-L/BORIS.

    Directory of Open Access Journals (Sweden)

    Manuel Rosa-Garrido

    Full Text Available CTCF is a ubiquitous epigenetic regulator that has been proposed as a master keeper of chromatin organisation. CTCF-like, or BORIS, is thought to antagonise CTCF and has been found in normal testis, ovary and a large variety of tumour cells. The cellular function of BORIS remains intriguing although it might be involved in developmental reprogramming of gene expression patterns. We here unravel the expression of CTCF and BORIS proteins throughout human epidermis. While CTCF is widely distributed within the nucleus, BORIS is confined to the nucleolus and other euchromatin domains. Nascent RNA experiments in primary keratinocytes revealed that endogenous BORIS is present in active transcription sites. Interestingly, BORIS also localises to interphase centrosomes suggesting a role in the cell cycle. Blocking the cell cycle at S phase or mitosis, or causing DNA damage, produced a striking accumulation of BORIS. Consistently, ectopic expression of wild type or GFP- BORIS provoked a higher rate of S phase cells as well as genomic instability by mitosis failure. Furthermore, down-regulation of endogenous BORIS by specific shRNAs inhibited both RNA transcription and cell cycle progression. The results altogether suggest a role for BORIS in coordinating S phase events with mitosis.

  1. Microbial Character Related Sulfur Cycle under Dynamic Environmental Factors Based on the Microbial Population Analysis in Sewerage System.

    Science.gov (United States)

    Dong, Qian; Shi, Hanchang; Liu, Yanchen

    2017-01-01

    The undesired sulfur cycle derived by microbial population can ultimately causes the serious problems of sewerage systems. However, the microbial community characters under dynamic environment factors in actual sewerage system is still not enough. This current study aimed to character the distributions and compositions of microbial communities that participate in the sulfur cycle under the dynamic environmental conditions in a local sewerage system. To accomplish this, microbial community compositions were assessed using 454 high-throughput sequencing (16S rDNA) combined with dsrB gene-based denaturing gradient gel electrophoresis. The results indicated that a higher diversity of microbial species was present at locations in sewers with high concentrations of H 2 S. Actinobacteria and Proteobacteria were dominant in the sewerage system, while Actinobacteria alone were dominant in regions with high concentrations of H 2 S. Specifically, the unique operational taxonomic units could aid to characterize the distinct microbial communities within a sewerage manhole. The proportion of sulfate-reducing bacteria, each sulfur-oxidizing bacteria (SOB) were strongly correlated with the liquid parameters (DO, ORP, COD, Sulfide, NH 3 -N), while the Mycobacterium and Acidophilic SOB (M&A) was strongly correlated with gaseous factors within the sewer, such as H 2 S, CH 4 , and CO. Identifying the distributions and proportions of critical microbial communities within sewerage systems could provide insights into how the microbial sulfur cycle is affected by the dynamic environmental conditions that exist in sewers and might be useful for explaining the potential sewerage problems.

  2. Creating Cycling-Friendly Environments for Children: Which Micro-Scale Factors Are Most Important? An Experimental Study Using Manipulated Photographs

    Science.gov (United States)

    Ghekiere, Ariane; Deforche, Benedicte; Mertens, Lieze; De Bourdeaudhuij, Ilse; Clarys, Peter; de Geus, Bas; Cardon, Greet; Nasar, Jack; Salmon, Jo; Van Cauwenberg, Jelle

    2015-01-01

    Background Increasing participation in transportation cycling represents a useful strategy for increasing children’s physical activity levels. Knowledge on how to design environments to encourage adoption and maintenance of transportation cycling is limited and relies mainly on observational studies. The current study experimentally investigates the relative importance of micro-scale environmental factors for children’s transportation cycling, as these micro-scale factors are easier to change within an existing neighborhood compared to macro-scale environmental factors (i.e. connectivity, land-use mix, …). Methods Researchers recruited children and their parents (n = 1232) via 45 randomly selected schools across Flanders and completed an online questionnaire which consisted of 1) demographic questions; and 2) a choice-based conjoint (CBC) task. During this task, participants chose between two photographs which we had experimentally manipulated in seven micro-scale environmental factors: type of cycle path; evenness of cycle path; traffic speed; traffic density; presence of speed bumps; environmental maintenance; and vegetation. Participants indicated which route they preferred to (let their child) cycle along. To find the relative importance of these micro-scale environmental factors, we conducted Hierarchical Bayes analyses. Results Type of cycle path emerged as the most important factor by far among both children and their parents, followed by traffic density and maintenance, and evenness of the cycle path among children. Among parents, speed limits and maintenance emerged as second most important, followed by evenness of the cycle path, and traffic density. Conclusion Findings indicate that improvements in micro-scale environmental factors might be effective for increasing children’s transportation cycling, since they increase the perceived supportiveness of the physical environment for transportation cycling. Investments in creating a clearly designated

  3. Soliton compression to few-cycle pulses with a high quality factor by engineering cascaded quadratic nonlinearities

    DEFF Research Database (Denmark)

    Zeng, Xianglong; Guo, Hairun; Zhou, Binbin

    2012-01-01

    We propose an efficient approach to improve few-cycle soliton compression with cascaded quadratic nonlinearities by using an engineered multi-section structure of the nonlinear crystal. By exploiting engineering of the cascaded quadratic nonlinearities, in each section soliton compression...... with a low effective order is realized, and high-quality few-cycle pulses with large compression factors are feasible. Each subsequent section is designed so that the compressed pulse exiting the previous section experiences an overall effective self-defocusing cubic nonlinearity corresponding to a modest...... soliton order, which is kept larger than unity to ensure further compression. This is done by increasing the cascaded quadratic nonlinearity in the new section with an engineered reduced residual phase mismatch. The low soliton orders in each section ensure excellent pulse quality and high efficiency...

  4. Effect of normal and tumor factors on different phases of cell populations cycle.

    Science.gov (United States)

    Inda, A M; García, A L; Errecalde, A L; Badrán, A F

    1999-12-01

    In the present experiments we studied the effect of extracts from intact liver (LE), ES2 tumor extract (TE), plasmas from intact mice (PI), and from tumor bearing animals (PT) on different phases of hepatocytes and renocytes cell cycles. C3HS 28-day-old male mice, standardized for periodicity analysis, were injected at 16:00 hours and killed every 4 hours during a circadian cycle at 20:00/04; 00:00/08; 04:00/12; 08:00/16; 12:00/20 and 16:00/24 (time of day/hours post treatment). Colchicine (2 microg/g) was injected 4 hours before killing them. Samples of livers and kidneys were processed for histology and mitotic index determinations. The results were expressed as colchicine arrested metaphases per 1000 nuclei. The TE, LE and PI had a promoting effect on the mitotic activity of hepatocytes during the first 12 hours post treatment. During the subsequent 12 hours, not only these treatments but also the PI had an inhibiting effect on the mitotic activity of the same cell population. Also the TE and the PT had a promoting effect on the mitotic activity of the renocytes during the first 12 hours while the effect of all treatments showed a clear inhibition of the mitotic activity studied during the last 12 hours. Taking into account the time elapsed between the injections and the measurements made in these light-dark synchronized animals, we conclude that the increase in mitotic index observed in those tissues stemmed from a reinitiation of cell-cycle traverse in a subpopulation of G2-arrested, noncycling cells.

  5. Factors influencing charge capacity of vanadium pentoxide thin films during lithium ion intercalation/deintercalation cycles

    International Nuclear Information System (INIS)

    Alamarguy, D.; Castle, J. E.; Ibris, N.; Salvi, A. M.

    2007-01-01

    The intercalation of vanadium pentoxide by lithium ions leads to a change in optical properties, a process that is of value in thin-film electrochromic devices. In this study, films of V 2 O 5 , deposited on indium tin oxide (ITO) glass coupons by a sol-gel process, were challenged by increasing numbers of charge-discharge cycles ranging from 72 to 589 full cycles. The samples were characterized by x-ray photoelectron spectroscopy (XPS) and then examined in the deintercalated state by time-of-flight secondary ion mass spectroscopy (SIMS). XPS enabled measurement of the thickness and composition of the solid-electrolyte interface and provided evidence of the residual V 4+ concentration within the top few nanometers of the surface. The SIMS profile gave direct information on the thickness of the films and on the thickness loss caused by rinsing the samples after the electrochemical exposure. Determination, by SIMS, of the concentration of lithium ions has enabled a correction to be made for the amount of inactive material within the electrochemically active region of the film. The SIMS depth profiles for lithium in the four samples are similar, with a marked buildup of Li at the interface with the ITO. This interphase zone had a thickness of ∼27 nm and was electrochemically inactive, enabling a further correction to be made. Thus, by means of the XPS and the SIMS results the chemistry and thickness of the films could be fully characterized. The remaining inconsistency between capacity (between 35% and 100% of the anticipated charge) and number of cycles is ascribed to edge effects arising from the method used for production of the coupons

  6. Cell cycle-dependent transcription factors control the expression of yeast telomerase RNA.

    Science.gov (United States)

    Dionne, Isabelle; Larose, Stéphanie; Dandjinou, Alain T; Abou Elela, Sherif; Wellinger, Raymund J

    2013-07-01

    Telomerase is a specialized ribonucleoprotein that adds repeated DNA sequences to the ends of eukaryotic chromosomes to preserve genome integrity. Some secondary structure features of the telomerase RNA are very well conserved, and it serves as a central scaffold for the binding of associated proteins. The Saccharomyces cerevisiae telomerase RNA, TLC1, is found in very low copy number in the cell and is the limiting component of the known telomerase holoenzyme constituents. The reasons for this low abundance are unclear, but given that the RNA is very stable, transcriptional control mechanisms must be extremely important. Here we define the sequences forming the TLC1 promoter and identify the elements required for its low expression level, including enhancer and repressor elements. Within an enhancer element, we found consensus sites for Mbp1/Swi4 association, and chromatin immunoprecipitation (ChIP) assays confirmed the binding of Mbp1 and Swi4 to these sites of the TLC1 promoter. Furthermore, the enhancer element conferred cell cycle-dependent regulation to a reporter gene, and mutations in the Mbp1/Swi4 binding sites affected the levels of telomerase RNA and telomere length. Finally, ChIP experiments using a TLC1 RNA-binding protein as target showed cell cycle-dependent transcription of the TLC1 gene. These results indicate that the budding yeast TLC1 RNA is transcribed in a cell cycle-dependent fashion late in G1 and may be part of the S phase-regulated group of genes involved in DNA replication.

  7. Engineering Margin Factors Used in the Design of the VVER Fuel Cycles

    Science.gov (United States)

    Lizorkin, M. P.; Shishkov, L. K.

    2017-12-01

    The article describes methods for determination of the engineering margin factors currently used to estimate the uncertainties of the VVER reactor design parameters calculated via the KASKAD software package developed at the National Research Center Kurchatov Institute. These margin factors ensure the meeting of the operating (design) limits and a number of other restrictions under normal operating conditions.

  8. Analysis of Factors Controlling Cell Cycle that Can Be Synchronized Nondestructively During Root Cap Development

    Energy Technology Data Exchange (ETDEWEB)

    Hawes, Martha

    2011-02-04

    Publications and presentations during the final funding period, including progress in defining the substrate specificity, the primary goal of the project, are listed below. Both short-term and long-term responses mediated by PsUGT1 have been characterized in transgenic or mutant pea, alfalfa, and Arabidopsis with altered expression of PsUGT1. Additional progress includes evaluation of the relationship between control of the cell cycle by PsUGT1 and other glycosyltransferase and glycosidase enzymes that are co-regulated in the legume root cap during the onset of mitosis and differentiation. Transcriptional profiling and multidimensional protein identification technology ('MudPIT') have been used to establish the broader molecular context for the mechanism by which PsUGT1 controls cell cycle in response to environmental signals. A collaborative study with the Norwegian Forest Research Institute (who provided $10,000.00 in supplies and travel funds for collaborator Dr. Toril Eldhuset to travel to Arizona and Dr. H. H. Woo to travel to Norway) made it possible to establish that the inducible root cap system for studying carbohydrate synthesis and solubilization is expressed in gymnosperm as well as angiosperm species. This discovery provides an important tool to amplify the potential applications of the research in defining conserved cell cycle machinery across a very broad range of plant species and habitats. The final work, published during 2009, revealed an additional surprising parallel with mammalian immune responses: The cells whose production is controlled by PsUGT1 appear to function in a manner which is analogous to that of white blood cells, by trapping and killing in an extracellular manner. This may explain why mutation within the coding region of PsUGT1 and its homolog in humans (UGT1) is lethal to plants and animals. The work has been the subject of invited reviews. A postdoctoral fellow, eight undergraduate students, four M.S. students and

  9. Factors affecting {sup 223}Ra therapy: clinical experience after 532 cycles from a single institution

    Energy Technology Data Exchange (ETDEWEB)

    Etchebehere, Elba C. [The University of Texas MD Anderson Cancer Center, Department of Nuclear Medicine, Houston, TX (United States); Campinas State University (Unicamp), Department of Nuclear Medicine, Campinas (Brazil); Milton, Denai R. [The University of Texas MD Anderson Cancer Center, Department of Biostatistics, Houston, TX (United States); Araujo, John C. [The University of Texas MD Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, TX (United States); Swanston, Nancy M.; Macapinlac, Homer A.; Rohren, Eric M. [The University of Texas MD Anderson Cancer Center, Department of Nuclear Medicine, Houston, TX (United States)

    2016-01-15

    The aim of this study was to identify baseline features that predict outcome in {sup 223}Ra therapy. We retrospectively reviewed 110 patients with metastatic castration-resistant prostate cancer treated with {sup 223}Ra. End points were overall survival (OS), progression-free survival (PFS), bone event-free survival (BeFS), and bone marrow failure (BMF). The following parameters were evaluated prior to the first {sup 223}Ra cycle: serum levels of hemoglobin (Hb), prostate-specific antigen (PSA), alkaline phosphatase (ALP), Eastern Cooperative Oncology Group (ECOG) status, pain score, use of chemotherapy, and external beam radiation therapy (EBRT). During/after {sup 223}Ra we evaluated: the total number of radium cycles (Ra{sub Tot}), the PSA doubling time (PSA{sub DT}), and the use of chemotherapy, EBRT, abiraterone, and enzalutamide. A significant reduction of ALP (p < 0.001) and pain score (p = 0.041) occurred throughout the {sup 223} Ra cycles. The risk of progression was associated with declining ECOG status [hazard ratio (HR) = 3.79; p < 0.001] and decrease in PSA{sub DT} (HR = 8.22; p < 0.001). Ra{sub Tot}, ALP, initial ECOG status, initial pain score, and use of abiraterone were associated with OS (p ≤ 0.008), PFS (p ≤ 0.003), and BeFS (p ≤ 0.020). Ra{sub Tot}, ALP, initial ECOG status, and initial pain score were significantly associated with BMF (p ≤ 0.001) as well as Hb (p < 0.001) and EBRT (p = 0.009). On multivariable analysis, only Ra{sub Tot} and abiraterone remained significantly associated with OS (p < 0.001; p = 0.033, respectively), PFS (p < 0.001; p = 0.041, respectively), and BeFS (p < 0.001; p = 0.019, respectively). Additionally, Ra{sub Tot} (p = 0.027) and EBRT (p = 0.013) remained significantly associated with BMF. Concomitant use of abiraterone and {sup 223}Ra seems to have a beneficial effect, while the EBRT may increase the risk of BMF. (orig.)

  10. Cycle inhibiting factors (CIFs are a growing family of functional cyclomodulins present in invertebrate and mammal bacterial pathogens.

    Directory of Open Access Journals (Sweden)

    Grégory Jubelin

    Full Text Available The cycle inhibiting factor (Cif produced by enteropathogenic and enterohemorrhagic Escherichia coli was the first cyclomodulin to be identified that is injected into host cells via the type III secretion machinery. Cif provokes cytopathic effects characterized by G(1 and G(2 cell cycle arrests, accumulation of the cyclin-dependent kinase inhibitors (CKIs p21(waf1/cip1 and p27(kip1 and formation of actin stress fibres. The X-ray crystal structure of Cif revealed it to be a divergent member of a superfamily of enzymes including cysteine proteases and acetyltransferases that share a conserved catalytic triad. Here we report the discovery and characterization of four Cif homologs encoded by different pathogenic or symbiotic bacteria isolated from vertebrates or invertebrates. Cif homologs from the enterobacteria Yersinia pseudotuberculosis, Photorhabdus luminescens, Photorhabdus asymbiotica and the beta-proteobacterium Burkholderia pseudomallei all induce cytopathic effects identical to those observed with Cif from pathogenic E. coli. Although these Cif homologs are remarkably divergent in primary sequence, the catalytic triad is strictly conserved and was shown to be crucial for cell cycle arrest, cytoskeleton reorganization and CKIs accumulation. These results reveal that Cif proteins form a growing family of cyclomodulins in bacteria that interact with very distinct hosts including insects, nematodes and humans.

  11. The reproduction of Blennius pavo (Teleostei, Blenniidae). I. Ovarial cycle, environmental factors and feeding

    Science.gov (United States)

    Patzner, Robert A.

    1983-03-01

    Blennius (Salaria) pavo is a very common coastal fish in the Mediterranean Sea. The development of the ovary was studied over a period of one year; seven stages of oogenesis are described. Ripe eggs are carried during the spawning season from Juni to August. The ovary shows a resting period of more than half a year (September to March). Environmental factors of the study area such as surface water temperature and daylength are described as well as the condition factors of male and female fish. Observations on food and behaviour during the winter months are also included.

  12. Human population intake fractions and environmental fate factors of toxic pollutants in life cycle impact assessment

    NARCIS (Netherlands)

    Huijbregts, M.A.J.; Struijs, Jaap; Goedkoop, Mark; Heijungs, Reinout; Jan Hendriks, A.; Van De Meent, Dik

    2005-01-01

    The present paper outlines an update of the fate and exposure part of the fate, exposure and effects model USES-LCA. The new fate and exposure module of USES-LCA was applied to calculate human population intake fractions and fate factors of the freshwater, marine and terrestrial environment for 3393

  13. Indoor Air Pollutant Exposure for Life Cycle Assessment: Regional Health Impact Factors for Households

    DEFF Research Database (Denmark)

    Rosenbaum, Ralph K.; Meijer, Arjen; Demou, Evangelia

    2015-01-01

    of magnitude, due to the variability of ventilation rate, building occupation, and volume. To compare health impacts as a result of indoor exposure with those from outdoor exposure, the indoor exposure characterization factors determined with the modified USEtox model were applied in a case study on cooking...

  14. Vicious and virtuous cycles in ERP implementation : a case study of interrelations between critical success factors

    NARCIS (Netherlands)

    Akkermans, H.A.; Helden, van K.

    2002-01-01

    ERP implementations are complex undertakings. Recent research has provided us with plausible critical success factors (CSFs) for such implementations. This article describes how one list of CSFs (Somers & Nelson, 2001) was used to analyse and explain project performance in one ERP implementation in

  15. From species sensitivity to hypoxia to effect factors modelling in life cycle impact assessment (LCIA)

    DEFF Research Database (Denmark)

    Cosme, Nuno Miguel Dias; Hauschild, Michael Zwicky

    ’s sensitivity in five climate zone (polar, subpolar, temperate, subtropical, tropical). Species Sensitivity Distribution (SSD) curves combining DO concentrations and Potentially Affected Fractions (PAF) of species were plotted to estimate hazard concentrations (HC50LOEL) per climate zone, and Effect Factors (EF...

  16. FACTORS THAT INFLUENCE IN SEDENTARY LIFESTYLE OF STUDENTS OF FOURTH CYCLE OF A PUBLIC HIGH SCHOOL

    Directory of Open Access Journals (Sweden)

    Carlos Álvarez Bogantes

    2015-08-01

    Full Text Available There is sufficient evidence to say that women as they move into the education system to reduce physical activity levels of sedentary lifestyle that put them at higher risk for non-communicable diseases. This led to determine the reasons for the inactivity of a group of fourth cycle. In order to address this problem, a qualitative design using focus groups and depth interviews was used, applied to30 women of high school participated. The results indicate that the participants are unaware of the benefits that can give them an active life, possibly affecting their movement behavior. A key element that have expressed is little impact of physical education classes when promoting lifestyles movement of the participants in this study, especially for ignoring the needs and barriers that students have. Become clear that the sport orientation of physical education classes and lack the skills to participate in activities successfully, sedentary activities of friends, the attitudes of parents; curriculum and lack of facilities also have significant impact in the studied group.

  17. Family extension and the elderly: economic, demographic, and family cycle factors.

    Science.gov (United States)

    Kobrin, F E

    1981-05-01

    This paper reports on the results of applying a multivariate regression model of living arrangements choices to census data on the 1970 U. S. population of nonmarried, nonparenting adults. The model examines the factors affecting living with (1) relatives or (2) living alone or with nonrelatives. These factors include sex, income, marital history, and age. In addition, the model tests whether living arrangements choices differ for the elderly relative to other ages. The analysis shows that higher income, the experience of divorce, and being male are all associated with a higher probability of nonfamily living. Widowhood has the same effect, but only for women. The central finding, however, is that there is no special role for the elderly in living arrangements choices.

  18. Computing the stretch factor and maximum detour of paths, trees, and cycles in the normed space

    DEFF Research Database (Denmark)

    Wulff-Nilsen, Christian; Grüne, Ansgar; Klein, Rolf

    2012-01-01

    (n log n) in the algebraic computation tree model and describe a worst-case O(σn log 2 n) time algorithm for computing the stretch factor or maximum detour of a path embedded in the plane with a weighted fixed orientation metric defined by σ time algorithm to d...... time. We also obtain an optimal O(n) time algorithm for computing the maximum detour of a monotone rectilinear path in L 1 plane....

  19. Recommendations for Life Cycle Impact Assessment in the European context - based on existing environmental impact assessment models and factors (International Reference Life Cycle Data System - ILCD handbook)

    OpenAIRE

    HAUSCHILD Michael; GOEDKOOP Mark; GUINEE Jerome; HEIJUNGS Reinout; HUIJBREGTS Mark; JOLLIET Olivier; MARGNI Manuele; DE SCHRYVER An

    2010-01-01

    To achieve more sustainable production and consumption patterns, we must consider the environmental implications of the whole supply-chain of products, both goods and services, their use, and waste management, i.e. their entire life cycle from ¿cradle to grave¿. In the Communication on Integrated Product Policy (IPP), (EC, 2003), the European Commission committed to produce a handbook on best practice in Life Cycle Assessment (LCA). The Sustainable Consumption and Production (SCP) Action ...

  20. Environmental life cycle assessment of grain maize production: An analysis of factors causing variability.

    Science.gov (United States)

    Boone, Lieselot; Van Linden, Veerle; De Meester, Steven; Vandecasteele, Bart; Muylle, Hilde; Roldán-Ruiz, Isabel; Nemecek, Thomas; Dewulf, Jo

    2016-05-15

    To meet the growing demand, high yielding, but environmentally sustainable agricultural plant production systems are desired. Today, life cycle assessment (LCA) is increasingly used to assess the environmental impact of these agricultural systems. However, the impact results are very diverse due to management decisions or local natural conditions. The impact of grain maize is often generalized and an average is taken. Therefore, we studied variation in production systems. Four types of drivers for variability are distinguished: policy, farm management, year-to-year weather variation and innovation. For each driver, scenarios are elaborated using ReCiPe and CEENE (Cumulative Exergy Extraction from the Natural Environment) to assess the environmental footprint. Policy limits fertilisation levels in a soil-specific way. The resource consumption is lower for non-sandy soils than for sandy soils, but entails however more eutrophication. Farm management seems to have less influence on the environmental impact when considering the CEENE only. But farm management choices such as fertiliser type have a large effect on emission-related problems (e.g. eutrophication and acidification). In contrast, year-to-year weather variation results in large differences in the environmental footprint. The difference in impact results between favourable and poor environmental conditions amounts to 19% and 17% in terms of resources and emissions respectively, and irrigation clearly is an unfavourable environmental process. The best environmental performance is obtained by innovation as plant breeding results in a steadily increasing yield over 25 years. Finally, a comparison is made between grain maize production in Flanders and a generically applied dataset, based on Swiss practices. These very different results endorse the importance of using local data to conduct LCA of plant production systems. The results of this study show decision makers and farmers how they can improve the

  1. Expression of hypoxia-inducible factor-1α and cell cycle proteins in invasive breast cancer are estrogen receptor related

    International Nuclear Information System (INIS)

    Bos, Reinhard; Diest, Paul J van; Groep, Petra van der; Shvarts, Avi; Greijer, Astrid E; Wall, Elsken van der

    2004-01-01

    The transcription factor hypoxia-inducible factor-1 (HIF-1) is a key regulator of the cellular response to hypoxia. Previous studies showed that concentrations of its subunit HIF-1α, as a surrogate for HIF-1 activity, are increased during breast carcinogenesis and can independently predict prognosis in breast cancer. During carcinogenesis, the cell cycle is progressively deregulated, and proliferation rate is a strong prognostic factor in breast cancer. In this study we undertook a detailed evaluation of the relationships between HIF-1α and cell cycle-associated proteins. In a representative estrogen receptor (ER) group of 150 breast cancers, the expression of HIF-1α, vascular endothelial growth factor, the ER, HER-2/neu, Ki-67, cyclin A, cyclin D 1 , p21, p53, and Bcl-2 was investigated by immunohistochemistry. High concentrations (5% or more) of HIF-1α were associated with increased proliferation as shown by positive correlations with Ki-67 (P < 0.001) and the late S–G2-phase protein cyclin A (P < 0.001), but not with the G1-phase protein cyclin D 1 . High HIF-1α concentrations were also strongly associated with p53 positivity (P < 0.001) and loss of Bcl-2 expression (P = 0.013). No association was found between p21 and HIF-1α (P = 0.105) in the whole group of patients. However, the subgroup of ER-positive cancers was characterized by a strong positive association between HIF-1α and p21 (P = 0.023), and HIF-1α lacked any relation with proliferation. HIF-1α overexpression is associated with increased proliferation, which might explain the adverse prognostic impact of increased concentrations of HIF-1α in invasive breast cancer. In ER-positive tumors, HIF-1α is associated with p21 but not against proliferation. This shows the importance of further functional analysis to unravel the role of HIF-1 in late cell cycle progression, and the link between HIF-1, p21, and ER

  2. Two cycles of plasma rich in growth factors (PRGF-Endoret) intra-articular injections improve stiffness and activities of daily living but not pain compared to one cycle on patients with symptomatic knee osteoarthritis.

    Science.gov (United States)

    Vaquerizo, Víctor; Padilla, Sabino; Aguirre, José Javier; Begoña, Leire; Orive, Gorka; Anitua, Eduardo

    2017-05-19

    To assess the clinical efficacy and safety of a treatment based on one cycle versus two cycles of intra-articular injections of plasma rich in growth factors (PRGF-Endoret) on patients with knee osteoarthritis (OA). Ninety patients with knee OA were included and evaluated. A total of 48 patients received one cycle (OC group) (3 injections on a weekly basis), while 42 patients received two cycles of PRGF-Endoret (TC group) spaced 6 months between them. Patients were evaluated with LEQUESNE and WOMAC scores before treatment and after 48 weeks. Safety assessment was also performed. A significant reduction of all assessed outcome measures was shown for both groups at 48 weeks compared with baseline values (P PRGF did not show a significantly higher pain reduction compared with one cycle treatment. However, two cycles of PRGF showed a significant improvement in WOMAC stiffness, LEQUESNE MCD, LEQUESNE ADV and LEQUESNE global subscales. Therefore, patients treated with two cycles present an improvement in quality of life. II.

  3. Endosulfan inhibiting the meiosis process via depressing expressions of regulatory factors and causing cell cycle arrest in spermatogenic cells.

    Science.gov (United States)

    Guo, Fang-Zi; Zhang, Lian-Shuang; Wei, Jia-Liu; Ren, Li-Hua; Zhang, Jin; Jing, Li; Yang, Man; Wang, Ji; Sun, Zhi-Wei; Zhou, Xian-Qing

    2016-10-01

    Endosulfan is a persistent organic pollutant and widely used in agriculture as a pesticide. It is present in air, water, and soil worldwide; therefore, it is a health risk affecting especially the reproductive system. The aim of this study was to evaluate the toxicity of endosulfan in the reproductive system. To investigate the effect of endosulfan on meiosis process, 32 rats were divided into four groups, treated with 0, 1, 5, and 10 mg/kg/day endosulfan, respectively, and sacrificed after the 21 days of treatments. Results show that endosulfan caused the reductions in sperm concentration and motility rate, which resulted into an increased in sperm abnormality rate; further, endosulfan induced downregulation of spermatogenesis- and oogenesis-specific basic helix-loop-helix transcription factor (Sohlh1) which controls the switch on meiosis in mammals, as well cyclin A1, cyclin-dependent kinases 1 (CDK1), and cyclin-dependent kinases 2 (CDK2). In vitro, endosulfan induced G2/M phase arrest in the spermatogenic cell cycle and caused proliferation inhibition. Moreover, endosulfan induced oxidative stress and DNA damage in vivo and vitro. The results suggested that endosulfan could inhibit the start of meiosis by downregulating the expression of Sohlh1 and induce G2/M phase arrest of cell cycle by decreasing the expression of cyclin A1, CDK1, and CDK2 via oxidative damage, which inhibits the meiosis process, and therefore decrease the amount of sperm.

  4. The Arabidopsis Transcription Factor AtTCP15 Regulates Endoreduplication by Modulating Expression of Key Cell-cycle Genes

    Institute of Scientific and Technical Information of China (English)

    Zi-Yu Li; Bin Li; Ai-Wu Dong

    2012-01-01

    Plant cells frequently undergo endoreduplication,a modified cell cycle in which genome is repeatedly replicated without cytokinesis.As the key step to achieve final size and function for cells,endoreduplication is prevalent during plant development.However,mechanisms to control the balance between endoreduplication and mitotic cell division are still poorly understood.Here,we show that the Arabidopsis TCP (CINCINNATA-like TEOSINTE BRANCHED1-CYCLOIDEA-PCF)-family transcription factor gene AtTCP15 is expressed in trichomes,as well as in rapidly dividing and vascular tissues.Expression of AtTCP15SRDX,AtTCP15 fused with a SRDX repressor domain,induces extra endoreduplication in trichomes and cotyledon cells in transgenic Arabidopsis.On the contrary,overexpression of AtTCP15 suppresses endoreduplication in trichomes and other examined cells.Misregulation of AtTCP15 affects the expression of several important genes involved in cell-cycle regulation.AtTCP15 protein binds directly to the promoter regions of CYCA2;3 and RETINOBLASTOMA-RELATED (RBR) genes,which play key roles in endoreduplication.Taken together,AtTCP15 plays an important role in regulating endoreduplication during Arabidopsis development.

  5. Two protocols to treat thin endometrium with granulocyte colony-stimulating factor during frozen embryo transfer cycles.

    Science.gov (United States)

    Xu, Bin; Zhang, Qiong; Hao, Jie; Xu, Dabao; Li, Yanping

    2015-04-01

    The efficacy of two granulocyte colony-stimulating factor (G-CSF) protocols for thin endometrium were investigated. Eighty-two patients were diagnosed with thin endometrium (endometrial scratch subgroups. Compared with previous cycles, endometrial thickness increased from 5.7 ± 0.7 mm to 8.1 ± 2.1 mm after G-CSF treatment (P Endometrial thickness increases were not significantly different between the two subgroups. The G-CSF with endometrial scratch subgroup established nominally higher though non-significant clinical pregnancy and live birth rates than the G-CSF only subgroup (53.8 % versus 42.9% and 38.5% versus 28.6%, respectively). Fifty-two patients underwent FET despite edometrial thickness less than 7 mm, and were included as controls. Significantly higher embryo implantation and clinical pregnancy rates were observed in the G-CSF group compared with the control group (31.5% versus 13.9%; P Endometrial scracth did not impair G-CSF treatment for thin endometrium and favoured pregnancy and live birth rates. For patients with thin endometrium, embryo transfer cancellation and G-CSF treatment in subsequent FET cycles is beneficial. Copyright © 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  6. Physical factors controlling carbon cycling dynamics in blackwater river-dominated and particle dominated estuaries

    Science.gov (United States)

    Arellano, A. R.; Bianchi, T. S.; Osburn, C. L.; D'Sa, E. J.; Oviedo-Vargas, D.; Ward, N. D.; Joshi, I.

    2017-12-01

    While most blue carbon habitat (wetlands, seagrass beds and mangroves) research has focused on carbon burial/stocks and habitat fragmentation of these communities, few studies have examined physical factors that control exports and losses of blue carbon sources of organic matter (OM) to adjacent coastal waters. Here, we report on spatiotemporal changes in the composition and concentration of dissolved organic carbon (DOC), particulate organic carbon (POC), particulate nitrogen, pCO2, δ13C-DOC, δ13C-POC, δ13C-CO2, dissolved lignin-phenols (dΣ8), particulate lignin-phenols (pΣ8) and carbon normalized dissolved and particulate lignin phenol yields (dΛ8 and pΛ8) in surface waters of the Apalachicola and Barataria bays in the Gulf of Mexico. Discriminant analysis described spatial variability along canonical axis I (24.4%) while temporal variability was explained by canonical axis II (23.2%). Apalachicola Bay was low in POC concentration and characterized by high values for pCO2, DOC, C:N, dΣ8 and (Ad:Al)V. The latter three parameters indicated a clear terrestrial source of OM at Apalachicola Bay reflecting the importance of riverine DOM inputs in this system. In contrast, Barataria Bay was characterized by high values for POC, C:V, S:V, and δ13C-POC, indicating blue-carbon sources due to a lack of direct river inputs and high prevalence of wetlands, some recently submerged. Extreme weather, such as intense precipitation events in Apalachicola Bay and enhanced northerly winds in Barataria Bay were characterized by δ13C-CO2, dΛ8, C:V (Barataria), and C:N (Apalachicola). Results indicate that such physical factors can exert strong control on OM sources and sinks across the gradient of coastal wetlands and shelf waters and lead to enhanced transfer and degradation of wetland-derived blue carbon in coastal waters.

  7. Where is My Pay? Critical Success Factors of a Payroll System – A System Life Cycle Approach

    Directory of Open Access Journals (Sweden)

    Mohan Thite

    2014-06-01

    Full Text Available Majority of firms deploy technologies in HR administrative applications. While payroll processing is a routine transactional activity, poor design and implementation of payroll system can cause immense harm to employee and organizational well-being. Based on the case study of a flawed payroll system in a large and complex public sector organization in Australia, we highlight the key success factors using the system life cycle approach underpinned by the agile philosophy. It highlights the critical importance of strategic organizational review, user involvement and ongoing communication with diverse stakeholders during the planning, analysis, design, implementation and review stages of a payroll project. It reinforces the need for the adoption of and adherence to sound project and change management methodologies. We also explore the limitations of shared service center approach.

  8. Life cycle assessment in wastewater treatment: : Influence of site-oriented normalization factors, life cycle impact assessment methods, and weighting methods

    NARCIS (Netherlands)

    Bai, Shunwen; Wang, Xiuheng; Zhang, X.; Zhao, Xinyue; Ren, N

    2017-01-01

    This present study aims to analyze the differences in results of different site-directional life cycle assessment
    (LCA) methods applied in the field of wastewater treatment. Site-generic methods were employed and
    compared with China-specific methods on a full-scale wastewater treatment case.

  9. Bikeability – Urban structures supporting cycling. Effects of local, urban and regional scale urban form factors on cycling from home and workplace locations in Denmark

    DEFF Research Database (Denmark)

    Nielsen, Thomas Alexander Sick; Skov-Petersen, Hans

    2018-01-01

    This study applies micro-level transport survey data to assess the significance of Bikeability variables on the probability of cycling in trips to or from residential and workplace locations. The data and analysis were prepared to include measures at different spatial scales, including measures...

  10. Corporate Social Responsibility and Employee Engagement: Enabling Employees to Employ More of Their Whole Selves at Work.

    Science.gov (United States)

    Glavas, Ante

    2016-01-01

    Research at the individual level of corporate social responsibility (CSR) has been growing rapidly. Yet we still lack a more complete understanding of why and how individuals (i.e., employees) are affected by CSR. This study contributes to that gap by exploring the relationship between CSR and employee engagement. Moreover, in order to address the problem of low levels of employee engagement in the workplace, CSR is proposed and tested as a pathway for engaging a significant part of the workforce. Building on engagement theory, a model is tested in which CSR enables employees to bring more of their whole selves to work, which results in employees being more engaged. Data from 15,184 employees in a large professional service firm in the USA was analyzed using structural equation modeling. Results show that authenticity (i.e., being able to show one's whole self at work) positively and significantly mediates the relationship between CSR and employee engagement. However, the other mediator tested in this study, perceived organizational support (POS; i.e., direct benefits to the employee), did not significantly mediate the relationship. In addition, results of moderated mediation suggest that when CSR is extra-role (i.e., not embedded in one's job design such as volunteering), it weakens the relationship between CSR and employee engagement. Moreover, post hoc analyses show that even when POS is controlled for, authenticity has an impact above and beyond POS on employee engagement. These results extend prior CSR literature which has often been top-down and has focused on how employees will be positively affected by what the organization can give them (e.g., POS). Rather, a bottom-up approach might reveal that the more that employees can give of their whole selves, the more engaged they might be at work.

  11. Corporate Social Responsibility and Employee Engagement: Enabling Employees to Employ More of Their Whole Selves at Work

    Directory of Open Access Journals (Sweden)

    Ante eGlavas

    2016-05-01

    Full Text Available Research at the individual level of corporate social responsibility (CSR has been growing rapidly. Yet we still lack a more complete understanding of why and how individuals (i.e., employees are affected by CSR. This study contributes to that gap by exploring the relationship between CSR and employee engagement. Moreover, in order to address the problem of low levels of employee engagement in the workplace, CSR is proposed and tested as a pathway for engaging a significant part of the workforce. Building on engagement theory, a model is tested in which CSR enables employees to bring more of their whole selves to work, which results in employees being more engaged. Data from 15,184 employees in a large professional service firm in the U.S. was analyzed using structural equation modeling. Results show that authenticity (i.e., being able to show one’s whole self at work positively and significantly mediates the relationship between CSR and employee engagement. However, the other mediator tested in this study, perceived organizational support (POS; i.e., direct benefits to the employee, did not significantly mediate the relationship. In addition, results of moderated mediation suggest that when CSR is extra-role (i.e., not embedded in one’s job design such as volunteering, it weakens the relationship between CSR and employee engagement. Moreover, post hoc analyses show that even when POS is controlled for, authenticity has an impact above and beyond POS on employee engagement. These results extend prior CSR literature which has often been top-down and has focused on how employees will be positively affected by what the organization can give them (e.g., POS. Rather, a bottom-up approach might reveal that the more that employees can give of their whole selves, the more engaged they might be at work.

  12. Uptake and economic impact of first-cycle colony-stimulating factor use during adjuvant treatment of breast cancer.

    Science.gov (United States)

    Hershman, Dawn L; Wilde, Elizabeth T; Wright, Jason D; Buono, Donna L; Kalinsky, Kevin; Malin, Jennifer L; Neugut, Alfred I

    2012-03-10

    In 2002, pegfilgrastim was approved by the US Food and Drug Administration and the benefits of dose-dense breast cancer chemotherapy, especially for hormone receptor (HR) -negative tumors, were reported. We examined first-cycle colony-stimulating factor use (FC-CSF) before and after 2002 and estimated US expenditures for dose-dense chemotherapy. We identified patients in Surveillance, Epidemiology, and End Results-Medicare greater than 65 years old with stages I to III breast cancer who had greater than one chemotherapy claim within 6 months of diagnosis(1998 to 2005) and classified patients with an average cycle length less than 21 days as having received dose-dense chemotherapy. The associations of patient, tumor, and physician-related factors with the receipt of any colony-stimulating factor (CSF) and FC-CSF use were analyzed by using generalized estimating equations. CSF costs were estimated for patients who were undergoing dose-dense chemotherapy. Among the 10,773 patients identified, 5,266 patients (48.9%) had a CSF claim. CSF use was stable between 1998 and 2002 and increased from 36.8% to 73.7% between 2002 and 2005, FC-CSF use increased from 13.2% to 67.9%, and pegfilgrastim use increased from 4.1% to 83.6%. In a multivariable analysis, CSF use was associated with age and chemotherapy type and negatively associated with black/Hispanic race, rural residence, and shorter chemotherapy duration. FC-CSF use was associated with high socioeconomic status but not with age or race/ethnicity. The US annual CSF expenditure for women with HR-positive tumors treated with dose-dense chemotherapy is estimated to be $38.8 million. A rapid increase in FC-CSF use occurred over a short period of time, which was likely a result of the reported benefits of dose-dense chemotherapy and the ease of pegfilgrastim administration. Because of the increasing evidence that elderly HR-positive patients do not benefit from dose-dense chemotherapy, limiting pegfilgrastim use would combat

  13. Factors determining the long term back end nuclear fuel cycle strategy and future nuclear systems. Proceedings of a technical committee meeting

    International Nuclear Information System (INIS)

    2002-05-01

    The Technical Committee Meeting (TCM) was held in Vienna on 8-10 November 1999; it was organized by the International Atomic Energy Agency and attended by 26 participants from 16 Member States. The purpose of the meeting was to exchange information among experts on the back end fuel cycle strategies adopted by Member States; to identify key factors determining the long-term back end fuel cycle strategies; and to assess the applicability of these factors to future nuclear systems. Issues associated with the back end fuel cycle supporting a country's nuclear power programme are technical, economic, institutional and political. This TCM provided an opportunity to address these issues and their impacts to the back end fuel cycles, as well as to identify and assess factors affecting the back end fuel cycle strategies. The discussion was organized ib the following topical sessions: the nuclear fuel cycle; spent fuel management; waste management and repository; plutonium management. This document contains a summary of the meeting and 22 individual papers presented by participants. Each of the papers was indexed separately

  14. Factors determining the long term back end nuclear fuel cycle strategy and future nuclear systems. Proceedings of a technical committee meeting

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-05-01

    The Technical Committee Meeting (TCM) was held in Vienna on 8-10 November 1999; it was organized by the International Atomic Energy Agency and attended by 26 participants from 16 Member States. The purpose of the meeting was to exchange information among experts on the back end fuel cycle strategies adopted by Member States; to identify key factors determining the long-term back end fuel cycle strategies; and to assess the applicability of these factors to future nuclear systems. Issues associated with the back end fuel cycle supporting a country's nuclear power programme are technical, economic, institutional and political. This TCM provided an opportunity to address these issues and their impacts to the back end fuel cycles, as well as to identify and assess factors affecting the back end fuel cycle strategies. The discussion was organized ib the following topical sessions: the nuclear fuel cycle; spent fuel management; waste management and repository; plutonium management. This document contains a summary of the meeting and 22 individual papers presented by participants. Each of the papers was indexed separately.

  15. Life cycle impact assessment of home energy management systems (HEMS) using dynamic emissions factors for electricity in Finland

    International Nuclear Information System (INIS)

    Louis, Jean-Nicolas; Pongrácz, Eva

    2017-01-01

    Decarbonising the European economy is a long-term goal in which the residential sector will play a significant role. Smart buildings for energy management are one means of decarbonisation, by reducing energy consumption and related emissions. This study investigated the environmental impacts of smart house automation using life cycle impact assessment. The ReCiPe method was selected for use, in combination with dynamic emissions factors for electricity in Finland. The results indicated that a high level of technology deployment may be counter-effective, due to high electricity consumption by the sensor network, automation system and computing devices. The results also indicated that number of inhabitants per household directly affected the environmental impacts of home automation. A single-person household saw its environmental impacts increase by 15%, while those of a five-person household increased by 3% in the worst-case scenario. The manufacturing phase contributed the major share of environmental impacts, exceeding the use phase in multiple categories. These findings indicate that finding the sweet spot in which technology can promote decarbonisation will be crucial to achieving the goal of a low‑carbon economy. - Highlights: •HEMS did not reduce the overall environmental impact of households. •Environmental impacts of HEMS are greater for single inhabitant households. •Energy efficiency of sensing devices must drastically increase to promote decarbonisation. •The highest life cycle environmental impacts of electronics are during the manufacturing phase. •Raising awareness is a critical part in decreasing the environmental impact of households.

  16. Development of a life-cycle fugitive methane emissions model utilizing device level emissions and activity factors

    Science.gov (United States)

    Englander, J.; Brandt, A. R.

    2017-12-01

    There has been numerous studies in quantifying the scale of fugitive emissions from across the natural gas value chain. These studies have typically focused on either specific types of equipment (such as valves) or on a single part of the life-cycle of natural gas production (such as gathering stations).1,2 However it has been demonstrated that average emissions factors are not sufficient for representing leaks in the natural gas system.3 In this work, we develop a robust estimate of fugitive emissions rates by incorporating all publicly available studies done at the component up to the process level. From these known studies, we create a database of leaks with normalized nomenclature from which leak estimates can be drawn from actual leak observations. From this database, and parameterized by meta-data such as location, scale of study, or placement in the life-cycle, we construct stochastic emissions factors specific for each process unit. This will be an integrated tool as part of the Oil production greenhouse gas estimator (OPGEE) as well as the Fugitive Emissions Abatement Simulation Toolkit (FEAST) models to enhances their treatment of venting and fugitive emissions, and will be flexible to include user provided data and input parameters.4,51. Thoma, ED et al. Assessment of Uinta Basin Oil and Natural Gas Well Pad Pneumatic Controller Emissions. J. Environ. Prot. 2017. 2. Marchese, AJ et al. Methane Emissions from United States Natural Gas Gathering and Processing. ES&T 2015. doi:10.1021/acs.est.5b02275 3. Brandt, AR et al. Methane Leaks from Natural Gas Systems Follow Extreme Distributions. ES&T 2016. doi:10.1021/acs.est.6b04303 4. El-Houjeiri, HM et al. An open-source LCA tool estimating greenhouse gas emissions from crude oil production using field characteristics. ES&T 2013. doi: 10.1021/es304570m 5. Kemp, CE et al. Comparing Natural Gas Leakage Detection Technologies Using an Open-Source `Virtual Gas Field' Simulator. ES&T 2016. doi:10.1021/acs.est.5b

  17. Preliminary Study on Occupation and Lifestyle as Conditioning Factors in Women Menstrual Cycle in a Region of Venezuela

    Directory of Open Access Journals (Sweden)

    Maritza Rojas

    2014-09-01

    Full Text Available Objective: To describe the characteristics of menstrual cycle (MC of Venezuelan women of childbearing age, according to socio-demographic (with emphasis on occupation and medical variables, obstetric history, chemical agents exposure and lifestyles. Material and Methods: An observational, cross-sectional and descriptive study in 180 childbearing women was conducted, using a previous validated questionnaire. Results: MC duration had a median of 28.0 days, 25th percentile was at 28.0 days and the 75th percentile was 30.0 days, with a percentage of short (<24 days and long cycles (≥ 33 days of 3.9 and 2.2%, respectively. Menstrual bleeding duration had a median of 5.0 days, 25th percentile was 4.0 days and 75th percentile was 5 days. 151 women (83.9%, experienced irregularity of the MC and 146 (81.1% had irregular bleeding duration. Both irregularities were significantly greater among 20 to 34 years old and single women. A negative and significant correlation between age and duration of menstrual bleeding was detected (p = 0.035. When comparing bleeding duration with profession/occupation, a significant difference was established (Kruskal-Wallis: p < 0.05. This is consistent with some publications that show that menstrual alterations are more frequent in working women in some specific occupations and also in the ones working in shifts. According to chemical use, women that use pesticides show a significant difference between pesticides exposure and MC duration, which is consistent with previously reported studies. In the same way, there was a significant association between coffee consumption and menstrual disturbances, in both cases, bleeding and MC duration. However, there was no significance when that association was calculated based on the amount of estimated caffeine intake. Conclusions: Within the limitations concerning a descriptive study, both MC duration and bleeding, theoretically were within normal limits. However, the variability

  18. Coordination cycles

    Czech Academy of Sciences Publication Activity Database

    Steiner, Jakub

    2008-01-01

    Roč. 63, č. 1 (2008), s. 308-327 ISSN 0899-8256 Institutional research plan: CEZ:AV0Z70850503 Keywords : global games * coordination * crises * cycles and fluctuations Subject RIV: AH - Economics Impact factor: 1.333, year: 2008

  19. Physical Factors Correlate to Microbial Community Structure and Nitrogen Cycling Gene Abundance in a Nitrate Fed Eutrophic Lagoon.

    Science.gov (United States)

    Highton, Matthew P; Roosa, Stéphanie; Crawshaw, Josie; Schallenberg, Marc; Morales, Sergio E

    2016-01-01

    Nitrogenous run-off from farmed pastures contributes to the eutrophication of Lake Ellesmere, a large shallow lagoon/lake on the east coast of New Zealand. Tributaries periodically deliver high loads of nitrate to the lake which likely affect microbial communities therein. We hypothesized that a nutrient gradient would form from the potential sources (tributaries) creating a disturbance resulting in changes in microbial community structure. To test this we first determined the existence of such a gradient but found only a weak nitrogen (TN) and phosphorous gradient (DRP). Changes in microbial communities were determined by measuring functional potential (quantification of nitrogen cycling genes via nifH , nirS , nosZI , and nosZII using qPCR), potential activity (via denitrification enzyme activity), as well as using changes in total community (via 16S rRNA gene amplicon sequencing). Our results demonstrated that changes in microbial communities at a phylogenetic (relative abundance) and functional level (proportion of the microbial community carrying nifH and nosZI genes) were most strongly associated with physical gradients (e.g., lake depth, sediment grain size, sediment porosity) and not nutrient concentrations. Low nitrate influx at the time of sampling is proposed as a factor contributing to the observed patterns.

  20. Physical factors correlate to microbial community structure and nitrogen cycling gene abundance in a nitrate fed eutrophic lagoon

    Directory of Open Access Journals (Sweden)

    Matthew Paul Highton

    2016-10-01

    Full Text Available Nitrogenous run-off from farmed pastures contributes to the eutrophication of Lake Ellesmere, a large shallow lagoon/lake on the east coast of New Zealand. Tributaries periodically deliver high loads of nitrate to the lake which likely affect microbial communities therein. We hypothesized that a nutrient gradient would form from the potential sources (tributaries creating a disturbance resulting in changes in microbial community structure. To test this we first determined the existence of such a gradient but found only a weak nitrogen (TN and phosphorous gradient (DRP. Changes in microbial communities were determined by measuring functional potential (quantification of nitrogen cycling genes via nifH, nirS, nosZI and nosZII using qPCR, potential activity (via denitrification enzyme activity, as well as using changes in total community (via 16S rRNA gene amplicon sequencing. Our results demonstrated that changes in microbial communities at a phylogenetic (relative abundance and functional level (proportion of the microbial community carrying nifH and nosZI genes were most strongly associated with physical gradients (e.g. lake depth, sediment grain size, sediment porosity and not nutrient concentrations. Low nitrate influx at the time of sampling is proposed as a factor contributing to the observed patterns.

  1. Promoting Campus Cycling for Outdoor Recreation and Transportation: Investigating Factors Influencing Student Bicycle Usage on a Large, Southeastern University from an Ecological Perspective

    Science.gov (United States)

    Shields, Margaret M.; Thomas, Katherine H.; Paschal, Angelia; Tucker, Melanie; Leeper, James; Usdan, Stuart

    2017-01-01

    Biking is a popular recreational activity, and understanding how to promote participation is important to college health and recreation professionals. The purpose of this study was to examine factors contributing to cycling behaviors on one large college campus from an ecological perspective. Students were surveyed at a southeastern university in…

  2. Effects of Hybrid Cycle and Handcycle Exercise on Cardiovascular Disease Risk Factors in People with Spinal Cord Injury: a Randomized Controlled Trial

    NARCIS (Netherlands)

    Bakkum, A.J.T.; Paulson, T.A.W.; Bishop, N.C.; Goosey-Tolfrey, V.L.; Stolwijk-Swuste, J.M.; van Kuppevelt, D.J.; de Groot, S.; Janssen, T.W.J.

    2015-01-01

    Objective: To examine the effects of a 16-week exercise programme, using either a hybrid cycle or a handcycle, on cardiovascular disease risk factors in people with spinal cord injury. Participants: Nineteen individuals with spinal cord injury ≥ 8 years. Design: Multicentre randomized controlled

  3. Effects of Hybrid Cycle and Handcycle Exercise on Cardiovascular Disease Risk Factors in People with Spinal Cord Injury : A Randomized Controlled Trial

    NARCIS (Netherlands)

    Bakkum, Arjan J. T.; Paulson, Thomas A. W.; Bishop, Nicolette C.; Goosey-Tolfrey, Victoria L.; Stolwijk-Swuste, Janneke M.; van Kuppevelt, Dirk J.; de Groot, Sonja; Janssen, Thomas W. J.

    Objective: To examine the effects of a 16-week exercise programme, using either a hybrid cycle or a handcycle, on cardiovascular disease risk factors in people with spinal cord injury. Participants: Nineteen individuals with spinal cord injury >= 8 years. Design: Multicentre randomized controlled

  4. Primary granulocyte colony-stimulating factor prophylaxis during the first two cycles only or throughout all chemotherapy cycles in patients with breast cancer at risk for febrile neutropenia

    NARCIS (Netherlands)

    Aarts, M.J.; Peters, F.P.; Mandigers, C.M.P.W.; Dercksen, M.W.; Stouthard, J.M.; Nortier, H.J.; Laarhoven, H.W.M. van; Warmerdam, L.J. van; Wouw, A.J. van de; Jacobs, E.M.G.; Mattijssen, V.; Rijt, C.C. van der; Smilde, T.J.; Velden, A.W. van der; Temizkan, M.; Batman, E.; Muller, E.W.; Gastel, S.M. van; Borm, G.F.; Tjan-Heijnen, V.C.

    2013-01-01

    PURPOSE: Early breast cancer is commonly treated with anthracyclines and taxanes. However, combining these drugs increases the risk of myelotoxicity and may require granulocyte colony-stimulating factor (G-CSF) support. The highest incidence of febrile neutropenia (FN) and largest benefit of G-CSF

  5. Primary Granulocyte Colony-Stimulating Factor Prophylaxis During the First Two Cycles Only or Throughout All Chemotherapy Cycles in Patients With Breast Cancer at Risk for Febrile Neutropenia

    NARCIS (Netherlands)

    Aarts, Maureen J.; Peters, Frank P.; Mandigers, Caroline M.; Dercksen, M. Wouter; Stouthard, Jacqueline M.; Nortier, Hans J.; van Laarhoven, Hanneke W.; van Warmerdam, Laurence J.; van de Wouw, Agnes J.; Jacobs, Esther M.; Mattijssen, Vera; van der Rijt, Carin C.; Smilde, Tineke J.; van der Velden, Annette W.; Temizkan, Mehmet; Batman, Erdogan; Muller, Erik W.; van Gastel, Saskia M.; Borm, George F.; Tjan-Heijnen, Vivianne C. G.

    2013-01-01

    Purpose Early breast cancer is commonly treated with anthracyclines and taxanes. However, combining these drugs increases the risk of myelotoxicity and may require granulocyte colony-stimulating factor (G-CSF) support. The highest incidence of febrile neutropenia (FN) and largest benefit of G-CSF

  6. Factors associated with monozygosity in assisted reproductive technology pregnancies and the risk of recurrence using linked cycles.

    Science.gov (United States)

    Luke, Barbara; Brown, Morton B; Wantman, Ethan; Stern, Judy E

    2014-03-01

    To evaluate factors associated with monozygosity (MZ) (number of fetal heartbeats on early ultrasound greater than the number of embryos transferred) and the risk of recurrence in subsequent pregnancies using a national assisted reproduction database. Historical cohort study. Clinic-based data. 197,327 pregnancies (including 2,824 with evidence of MZ) from cycles reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) between 2004 and 2010. None. Evidence of MZ, adjusted odds ratios and their 95% confidence intervals computed from logistic regression models. In the univariate analysis, the risk of MZ was increased with ovulation disorders, donor oocytes, gonadotropin-releasing hormone agonist (GnRH-a) suppression, assisted hatching (AZH), and day 5-6 transfer, and was decreased with higher follicle-stimulating hormone (FSH) doses (≥3,000 IU). In the multivariate analysis, the risk of MZ was increased with GnRH-a suppression, AZH, and decreased with intracytoplasmic sperm injection (ICSI) and higher FSH dose. The interaction showed that although MZ was more likely with day 5-6 embryos, AZH had a minimal nonsignificant effect, whereas in day 2-3 embryos, AZH had a substantial statistically significant effect. Only one woman had a recurrence of MZ in a subsequent assisted reproduction pregnancy, which is consistent with randomness. The risk of MZ was higher with fresh day 5-6 embryos, donor oocytes, GnRH-a suppression, lower FSH doses, and AZH (particularly with day 2-3 embryos). Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  7. SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation.

    Science.gov (United States)

    Lin, Yingbo; Liu, Hongyu; Waraky, Ahmed; Haglund, Felix; Agarwal, Prasoon; Jernberg-Wiklund, Helena; Warsito, Dudi; Larsson, Olle

    2017-10-01

    Increasing number of studies have shown nuclear localization of the insulin-like growth factor 1 receptor (nIGF-1R) in tumor cells and its links to adverse clinical outcome in various cancers. Any obvious cell physiological roles of nIGF-1R have, however, still not been disclosed. Previously, we reported that IGF-1R translocates to cell nucleus and modulates gene expression by binding to enhancers, provided that the receptor is SUMOylated. In this study, we constructed stable transfectants of wild type IGF1R (WT) and triple-SUMO-site-mutated IGF1R (TSM) using igf1r knockout mouse fibroblasts (R-). Cell clones (R-WT and R-TSM) expressing equal amounts of IGF-1R were selected for experiments. Phosphorylation of IGF-1R, Akt, and Erk upon IGF-1 stimulation was equal in R-WT and R-TSM. WT was confirmed to enter nuclei. TSM did also undergo nuclear translocation, although to a lesser extent. This may be explained by that TSM heterodimerizes with insulin receptor, which is known to translocate to cell nuclei. R-WT proliferated substantially faster than R-TSM, which did not differ significantly from the empty vector control. Upon IGF-1 stimulation G1-S-phase progression of R-WT increased from 12 to 38%, compared to 13 to 20% of R-TSM. The G1-S progression of R-WT correlated with increased expression of cyclin D1, A, and CDK2, as well as downregulation of p27. This suggests that SUMO-IGF-1R affects upstream mechanisms that control and coordinate expression of cell cycle regulators. Further studies to identify such SUMO-IGF-1R dependent mechanisms seem important. © 2017 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals Inc.

  8. Obesity, free testosterone, and cardiovascular risk factors in adolescents with polycystic ovary syndrome and regularly cycling adolescents.

    Science.gov (United States)

    Glueck, Charles J; Morrison, John A; Friedman, Lisa Aronson; Goldenberg, Naila; Stroop, Davis M; Wang, Ping

    2006-04-01

    Adolescent girls with polycystic ovary syndrome (PCOS) have increased levels of factors constituting the metabolic syndrome: centripetal obesity, hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), and hyperinsulinemia. Given the strong association reported between early, persistent obesity and development of metabolic syndrome 10 years later in girls, we speculated that if adolescent girls without PCOS had obesity measures similar to girls with PCOS, they would exhibit similar metabolic syndrome-cardiovascular disease risk factors. Within this context, we compared 37 adolescent girls with PCOS and 2 samples of normal, regularly cycling adolescent girls (controls) of similar ages, selected from the Cincinnati Clinic of the National Heart, Lung, and Blood Institute Growth and Health Study. The first sample included 157 controls selected using a stratified random sample based on age. As expected, girls with PCOS had higher body mass index (BMI), waist circumference, insulin, systolic blood pressure (SBP) and diastolic blood pressure, triglycerides (TGs), lower HDL-C, and higher low-density lipoprotein cholesterol (LDL-C) and free testosterone (FT) than controls. A second sample consisted of girls matched one to one with girls with PCOS for BMI and age. Comparisons of group differences were not significant for insulin, lipids, or blood pressure; girls with PCOS had a trend toward higher values for waist circumference (median, 92.7 vs 87.5 cm; P = .07) and much higher median FT (4.25 vs 1.42 ng/mL, P = .0001). After matching for BMI and age, by conditional regression analysis, we showed that the groups were not differentiated (P > .15) by insulin, HDL-C, LDL-C, TG, SBP, or diastolic blood pressure, but were differentiated by higher FT (P = .0024) and waist circumference (P = .0024) in PCOS than in controls. Prospective longitudinal analyses of NHGS controls showed that changes in BMI from ages 9 to 10 years to ages 15 to 16 years were

  9. Sustainability Efficiency Factor: Measuring Sustainability in Advanced Energy Systems through Exergy, Exergoeconomic, Life Cycle, and Economic Analyses

    Science.gov (United States)

    Boldon, Lauren

    The Encyclopedia of Life Support Systems defines sustainability or industrial ecology as "the wise use of resources through critical attention to policy, social, economic, technological, and ecological management of natural and human engineered capital so as to promote innovations that assure a higher degree of human needs fulfilment, or life support, across all regions of the world, while at the same time ensuring intergenerational equity" (Encyclopedia of Life Support Systems 1998). Developing and integrating sustainable energy systems to meet growing energy demands is a daunting task. Although the technology to utilize renewable energies is well understood, there are limited locations which are ideally suited for renewable energy development. Even in areas with significant wind or solar availability, backup or redundant energy supplies are still required during periods of low renewable generation. This is precisely why it would be difficult to make the switch directly from fossil fuel to renewable energy generation. A transition period in which a base-load generation supports renewables is required, and nuclear energy suits this need well with its limited life cycle emissions and fuel price stability. Sustainability is achieved by balancing environmental, economic, and social considerations, such that energy is produced without detriment to future generations through loss of resources, harm to the environment, etcetera. In essence, the goal is to provide future generations with the same opportunities to produce energy that the current generation has. This research explores sustainability metrics as they apply to a small modular reactor (SMR)-hydrogen production plant coupled with wind energy and storage technologies to develop a new quantitative sustainability metric, the Sustainability Efficiency Factor (SEF), for comparison of energy systems. The SEF incorporates the three fundamental aspects of sustainability and provides SMR or nuclear hybrid energy system

  10. Identification of decisive factors for greenhouse gas emissions in comparative life cycle assessments of food waste management – an analytical review

    DEFF Research Database (Denmark)

    Bernstad, Anna; Wenzel, Henrik; Jansen, Jes la Cour

    2016-01-01

    . Secondly, to identify decisive factors in general and related to system boundary settings in particular, in reviewed studies. A number of criteria were constructed for identification of relevant comparative life cycle assessments, resulting in selection of nineteen studies, containing 103 different......A review of existing life cycle assessments on food waste management was made with two main aims. Firstly, to make an overview of the assessments of the global warming potential from the treatment alternatives incineration, landfill, anaerobic digestion and compost in studies reported in literature...

  11. Dose-rate conversion factors for external exposure to photon and electron radiation from radionuclides occurring in routine releases from nuclear fuel cycle facilities

    International Nuclear Information System (INIS)

    Kocher, D.C.

    1980-01-01

    Dose-rate conversion factors for external exposure to photon and electron radiation are calculated for 240 radionuclides of potential importance in routine releases from nuclear fuel cycle facilities. Exposure modes considered are immersion in contaminated air, immersion in contaminated water, and irradiation from a contaminated ground surface. For each exposure mode, dose-rate conversion factors for photons and electrons are calculated for tissue-equivalent material at the body surface of an exposed individual. Dose-rate conversion factors for photons only are calculated for 22 body organs. (author)

  12. Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells.

    Science.gov (United States)

    Bruni, R; Roizman, B

    1998-11-01

    The herpes simplex virus 1 infected cell protein 22 (ICP22), the product of the alpha22 gene, is a nucleotidylylated and phosphorylated nuclear protein with properties of a transcriptional factor required for the expression of a subset of viral genes. Here, we report the following. (i) ICP22 interacts with a previously unknown cellular factor designated p78 in the yeast two-hybrid system. The p78 cDNA encodes a polypeptide with a distribution of leucines reminiscent of a leucine zipper. (ii) In uninfected and infected cells, antibody to p78 reacts with two major bands with an apparent Mr of 78,000 and two minor bands with apparent Mrs of 62, 000 and 55,000. (ii) p78 also interacts with ICP22 in vitro. (iii) In uninfected cells, p78 was dispersed largely in the nucleoplasm in HeLa cells and in the nucleoplasm and cytoplasm in HEp-2 cells. After infection, p78 formed large dense bodies which did not colocalize with the viral regulatory protein ICP0. (iv) Accumulation of p78 was cell cycle dependent, being highest very early in S phase. (v) The accumulation of ICP22 in synchronized cells was highest in early S phase, in contrast to the accumulation of another protein, ICP27, which was relatively independent of the cell cycle. (vi) In the course of the cell cycle, ICP22 was transiently modified in an aberrant fashion, and this modification coincided with expression of p78. The results suggest that ICP22 interacts with and may be stabilized by cell cycle-dependent proteins.

  13. 14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr

    Directory of Open Access Journals (Sweden)

    Sakai Keiko

    2008-04-01

    Full Text Available Abstract Background Despite continuing advances in our understanding of AIDS pathogenesis, the mechanism of CD4+ T cell depletion in HIV-1-infected individuals remains unclear. The HIV-1 Vpr accessory protein causes cell death, likely through a mechanism related to its ability to arrest cells in the G2,M phase. Recent evidence implicated the scaffold protein, 14-3-3, in Vpr cell cycle blockade. Results We found that in human T cells, 14-3-3 plays an active role in mediating Vpr-induced cell cycle arrest and reveal a dramatic increase in the amount of Cdk1, Cdc25C, and CyclinB1 bound to 14-3-3 θ during Vprv-induced G2,M arrest. By contrast, a cell-cycle-arrest-dead Vpr mutant failed to augment 14-3-3 θ association with Cdk1 and CyclinB1. Moreover, G2,M arrest caused by HIV-1 infection strongly correlated with a disruption in 14-3-3 θ binding to centrosomal proteins, Plk1 and centrin. Finally, Vpr caused elevated levels of CyclinB1, Plk1, and Cdk1 in a complex with the nuclear transport and spindle assembly protein, importin β. Conclusion Thus, our data reveal a new facet of Vpr-induced cell cycle arrest involving previously unrecognized abnormal rearrangements of multiprotein assemblies containing key cell cycle regulatory proteins. Reviewers This article was reviewed by David Kaplan, Nathaniel R. Landau and Yan Zhou.

  14. Enterprise systems' life cycle in pursuit of resilient smart factory for emerging aircraft industry: a synthesis of Critical Success Factors'(CSFs), theory, knowledge gaps, and implications

    Science.gov (United States)

    Rashid, Asif; Masood, Tariq; Erkoyuncu, John Ahmet; Tjahjono, Benny; Khan, Nawar; Shami, Muiz-ud-din

    2018-02-01

    The research aims to investigate business value critical success factors (CSFs) of enterprise systems (ES) through their life cycle in pursuit of resilient smart factory for emerging aircraft industry. This article provides an extensive literature analysis of past 22 years based on conscientious criteria of authors: (i) who have published strategic content relevant to CSFs, (ii) received more than 300 citations and (iii) concurrently published two or more papers relevant to ES CSFs. The most cited strategic CSFs were termed as classical CSFs. The 22 CSFs were identified, validated and synthesised for better understanding of success across life cycle by aircraft industry experts. The top 10 empirically verified CSFs have numerous differences with past generic classical CSFs. This article canvases real insights of two distinct views: process and variance approaches of the ES CSFs. The process approach, which is a neglected research area, facilitates the researchers for identification of ES life cycle process coupled with a view of resource deployment when it is needed the most. While the variance approach facilitates practitioners and researchers in finding out which resource (CSF) is relatively more important. The significant findings for ES life cycle can help the practitioners and researchers to make rational decisions throughout the ES life cycle.

  15. Life cycle assessment of lignocellulosic ethanol: a review of key factors and methods affecting calculated GHG emissions and energy use.

    Science.gov (United States)

    Gerbrandt, Kelsey; Chu, Pei Lin; Simmonds, Allison; Mullins, Kimberley A; MacLean, Heather L; Griffin, W Michael; Saville, Bradley A

    2016-04-01

    Lignocellulosic ethanol has potential for lower life cycle greenhouse gas emissions compared to gasoline and conventional grain-based ethanol. Ethanol production 'pathways' need to meet economic and environmental goals. Numerous life cycle assessments of lignocellulosic ethanol have been published over the last 15 years, but gaps remain in understanding life cycle performance due to insufficient data, and model and methodological issues. We highlight key aspects of these issues, drawing on literature and a case study of corn stover ethanol. Challenges include the complexity of feedstock/ecosystems and market-mediated aspects and the short history of commercial lignocellulosic ethanol facilities, which collectively have led to uncertainty in GHG emissions estimates, and to debates on LCA methods and the role of uncertainty in decision making. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Changes in serum concentrations of growth hormone, insulin, insulin-like growth factor and insulin-like growth factor-binding proteins 1 and 3 and urinary growth hormone excretion during the menstrual cycle

    DEFF Research Database (Denmark)

    Juul, A; Scheike, Thomas Harder; Pedersen, A T

    1997-01-01

    Few studies exist on the physiological changes in the concentrations of growth hormone (GH), insulin-like growth factors (IGF) and IGF-binding proteins (IGFBP) within the menstrual cycle, and some controversy remains. We therefore decided to study the impact of endogenous sex steroids on the GH-I...

  17. [Polarized light microscopy for evaluation of oocytes as a prognostic factor in the evolution of a cycle in assisted reproduction].

    Science.gov (United States)

    González-Ortega, C; Cancino-Villarreal, P; Alonzo-Torres, V E; Martínez-Robles, I; Pérez-Peña, E; Gutiérrez-Gutiérrez, A M

    2016-04-01

    Identification of the best embryos to transfer is a key element for success in assisted reproduction. In the last decade, several morphological criteria of oocytes and embryos were evaluated with regard to their potential for predicting embryo viability. The introduction of polarization light microscopy systems has allowed the visualization of the meiotic spindle and the different layers of the zona pellucida in human oocytes on the basis of birefringence in a non-destructive way. Conflicting results have been reported regarding the predictive value in ICSI cycles. To assess the predictive ability of meiotic spindle and zona pellucida of human oocytes to implant by polarized microscopy in ICSI cycles. Prospective and observational clinical study. 903 oocytes from 94 ICSI cycles were analyzed with polarized microscopy. Meiotic spindle visualization and zona pellucida birefringence values by polarized microscopy were correlated with ICSI cycles results. Meiotic spindle visualization and birefringence values of zona pellucida decreased in a direct basis with increasing age. In patients aged over the 35 years, the percentage of a visible spindle and mean zona pellucida birefringence was lower than in younger patients. Fertilization rate were higher in oocytes with visible meiotic spindle (81.3% vs. 64%; p vs. 39%; p=0.01). Fertilization rate was higher in oocytes with positive values of birefringence (77.5 % vs. 68.5% p=0.005) with similar embryo quality. Conception cycles showed oocytes with higher mean value of zona birefringence and visible spindle vs. no-conception cycles (pPolarized light microscopy improves oocyte selection, which significantly impacts in the development of embryos with greater implantation potential. The use of polarized light microscopy with sperm selection methods, blastocyst culture and deferred embryo transfers will contribute to transfer fewer embryos without diminishing rates of live birth and single embryo transfer will be more feasible.

  18. GHG emission factors for bioelectricity, biomethane, and bioethanol quantified for 24 biomass substrates with consequential life-cycle assessment

    DEFF Research Database (Denmark)

    Tonini, Davide; Hamelin, Lorie; Alvarado-Morales, Merlin

    2016-01-01

    Greenhouse gas (GHG) emission savings from biofuels dramatically depend upon the source of energy displaced and the effects induced outside the energy sector, for instance land-use changes (LUC). Using consequential life-cycle assessment and including LUC effects, this study provides GHG emission...

  19. Air pollution as a risk factor in health impact assessments of a travel mode shift towards cycling.

    Science.gov (United States)

    Raza, Wasif; Forsberg, Bertil; Johansson, Christer; Sommar, Johan Nilsson

    2018-01-01

    Promotion of active commuting provides substantial health and environmental benefits by influencing air pollution, physical activity, accidents, and noise. However, studies evaluating intervention and policies on a mode shift from motorized transport to cycling have estimated health impacts with varying validity and precision. To review and discuss the estimation of air pollution exposure and its impacts in health impact assessment studies of a shift in transport from cars to bicycles in order to guide future assessments. A systematic database search of PubMed was done primarily for articles published from January 2000 to May 2016 according to PRISMA guidelines. We identified 18 studies of health impact assessment of change in transport mode. Most studies investigated future hypothetical scenarios of increased cycling. The impact on the general population was estimated using a comparative risk assessment approach in the majority of these studies, whereas some used previously published cost estimates. Air pollution exposure during cycling was estimated based on the ventilation rate, the pollutant concentration, and the trip duration. Most studies employed exposure-response functions from studies comparing background levels of fine particles between cities to estimate the health impacts of local traffic emissions. The effect of air pollution associated with increased cycling contributed small health benefits for the general population, and also only slightly increased risks associated with fine particle exposure among those who shifted to cycling. However, studies calculating health impacts based on exposure-response functions for ozone, black carbon or nitrogen oxides found larger effects attributed to changes in air pollution exposure. A large discrepancy between studies was observed due to different health impact assessment approaches, different assumptions for calculation of inhaled dose and different selection of dose-response functions. This kind of assessments

  20. Air pollution as a risk factor in health impact assessments of a travel mode shift towards cycling

    Science.gov (United States)

    Raza, Wasif; Forsberg, Bertil; Johansson, Christer; Sommar, Johan Nilsson

    2018-01-01

    ABSTRACT Background: Promotion of active commuting provides substantial health and environmental benefits by influencing air pollution, physical activity, accidents, and noise. However, studies evaluating intervention and policies on a mode shift from motorized transport to cycling have estimated health impacts with varying validity and precision. Objective: To review and discuss the estimation of air pollution exposure and its impacts in health impact assessment studies of a shift in transport from cars to bicycles in order to guide future assessments. Methods: A systematic database search of PubMed was done primarily for articles published from January 2000 to May 2016 according to PRISMA guidelines. Results: We identified 18 studies of health impact assessment of change in transport mode. Most studies investigated future hypothetical scenarios of increased cycling. The impact on the general population was estimated using a comparative risk assessment approach in the majority of these studies, whereas some used previously published cost estimates. Air pollution exposure during cycling was estimated based on the ventilation rate, the pollutant concentration, and the trip duration. Most studies employed exposure-response functions from studies comparing background levels of fine particles between cities to estimate the health impacts of local traffic emissions. The effect of air pollution associated with increased cycling contributed small health benefits for the general population, and also only slightly increased risks associated with fine particle exposure among those who shifted to cycling. However, studies calculating health impacts based on exposure-response functions for ozone, black carbon or nitrogen oxides found larger effects attributed to changes in air pollution exposure. Conclusion: A large discrepancy between studies was observed due to different health impact assessment approaches, different assumptions for calculation of inhaled dose and different

  1. Concentration factors of uranium mineralization in VII depositional cycle of Shuixigou group, lower-middle Jurassic at Wukurqi uranium deposit, Yili basin

    International Nuclear Information System (INIS)

    Liu Taoyong

    2004-01-01

    Starting with the analysis on uranium mineralization, this paper emphatically discusses factors related to uranium concentration in VII depositional cycle, such as the structure, the paleoclimate, the lithofacies-paleogeography, the lithology, the hydrogeology, the geochemistry, and the content of effective reductant. The author suggests that key factors of uranium migration and concentration at Wukurqi uranium deposit are the existence of ore-hosting formation (sand body), the long-term recharge of oxygen and uranium-bearing groundwater, the existence of effective reductant in ore-hosting formation

  2. Variation of crack intensity factor in three compacted clay liners exposed to annual cycle of atmospheric conditions with and without geotextile cover.

    Science.gov (United States)

    Safari, E; Jalili Ghazizade, M; Abduli, M A; Gatmiri, B

    2014-08-01

    Performance of compacted clay liners commonly used as landfill barrier systems can be subject to decline in terms of hydraulic conductivity if left exposed to atmospheric conditions for an extended period of time prior to placement of overlaying layers. The resulting desiccation cracking can lead to increased hydraulic conductivity. Desiccation crack intensity was studied for three clayey soils commonly used for construction of landfill barrier system in a relatively large scale test setup exposed to real time atmospheric conditions over a complete annual cycle. A white separator geotextile cover was presumed to be capable of reducing the intensity of desiccation cracking through absorbing and maintaining higher amounts of moisture and reducing the temperature of the soil surface in comparison to a directly exposed soil surface. Desiccation cracking was monitored using a digital imaging technique for three compacted clay liners in two sets, one open to air and the second covered with the white geotextile. Crack intensity factor approached a relatively stable phase after certain cycles corresponding to atmospheric dry wet cycles. The results indicated that the white separator geotextile was capable of reducing the crack intensity factor by 37.4-45.9% throughout the experiment including the cyclic phase of desiccation cracking. During the stable phase, the maximum reduction in crack intensity factor of 90.4% as a result of applying geotextile cover was observed for the soil with the lowest plastic index and clay content and therefore the lowest magnitude of crack intensity factor. The other two soils with similar clay content but different plastic index showed 23.6% and 52.2% reductions in crack intensity factor after cyclic phase when covered with geotextile. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Structure and influence factors of fuel cycle costs of pebble bed HTRs with OTTO-fuel management

    Energy Technology Data Exchange (ETDEWEB)

    Jacke, S.

    1975-06-15

    The study in this paper can be divided into two parts. The first part deals with the analysis of the structure of the fuel cycle costs of today in 1974. A comparison is made between two pebble bed HTRs with OTTO-refueling-management (once-through) and a LWR of the type Biblis A. The two HTRs use different fuels: The one low-enriched Uranium (LOTTO), the other high-enriched Uranium and Thorium (TOTTO). The analysis of the structure of the fuel cycle costs consists of a discussion of the most important input parameters, and a comparison of each cost item. This study was made without adjustment of the core design to the changing market conditions. It is quite natural that an adaptation of the moderation ratio, of the conversion ratio, of the enrichment level, and of the burn-up may lower the fuel cycle costs. But the differences cannot be very important, and the results of this examination may remain valid, even on best adjustment conditions.

  4. Changes in serum concentrations of growth hormone, insulin, insulin-like growth factor and insulin-like growth factor-binding proteins 1 and 3 and urinary growth hormone excretion during the menstrual cycle

    DEFF Research Database (Denmark)

    Juul, A; Scheike, Thomas Harder; Pedersen, A T

    1997-01-01

    Few studies exist on the physiological changes in the concentrations of growth hormone (GH), insulin-like growth factors (IGF) and IGF-binding proteins (IGFBP) within the menstrual cycle, and some controversy remains. We therefore decided to study the impact of endogenous sex steroids on the GH......-IGF-IGFBP axis during the ovulatory menstrual cycle in 10 healthy women (aged 18-40 years). Blood sampling and urinary collection was performed every morning at 0800 h for 32 consecutive days. Every second day the subjects were fasted overnight before blood sampling. Follicle stimulating hormone, luteinizing...... hormone (LH), oestradiol, progesterone, IGF-I, IGFBP-3, sex hormone-binding globulin, dihydroepiandrosterone sulphate and GH were determined in all samples, whereas insulin and IGFBP-1 were determined in fasted samples only. Serum IGF-I concentrations showed some fluctuation during the menstrual cycle...

  5. Size, Value and Business Cycle Variables. The Three-Factor Model and Future Economic Growth: Evidence from an Emerging Market

    Directory of Open Access Journals (Sweden)

    Fahad Ali

    2018-02-01

    Full Text Available The paper empirically investigates three different methods to construct factors and identifies some pitfalls that arise in the application of Fama-French’s three-factor model to the Pakistani stock returns. We find that the special features in Pakistan significantly affect size and value factors and also influence the explanatory power of the three-factor model. Additionally, the paper examines the ability of the three factors to predict the future growth of Pakistan’s economy. Using monthly data of both financial and non-financial companies between 2002 and 2016, the article empirically investigates and finds that: (1 size and book-to-market factors exist in the Pakistani stock market, two mimic portfolios SMB and HML generate a return of 9.15% and 12.27% per annum, respectively; (2 adding SMB and HML factors into the model meaningfully increases the explanatory power of the model; and (3 the model’s factors, except for value factor, predict future gross domestic product (GDP growth of Pakistan and remain robust. Our results are robust across sub-periods, risk regimes, and under three different methods of constructing the factors.

  6. Analysis of lead/acid battery life cycle factors: their impact on society and the lead industry

    Science.gov (United States)

    Robertson, J. G. S.; Wood, J. R.; Ralph, B.; Fenn, R.

    The underlying theme of this paper is that society, globally, is undergoing a fundamental conceptual shift in the way it views the environment and the role of industry within it. There are views in certain quarters that this could result in the virtual elimination of the lead industry's entire product range. Despite these threats, it is argued that the prospects for the lead industry appear to be relatively favourable in a number of respects. The industry's future depends to a significant degree, however, upon its ability to argue its case in a number of key areas. It is contended, therefore, that if appropriate strategies and means are promulgated, the prospects of the industry would appear to be relatively healthy. But, for this to happen with optimal effectiveness, a conceptual change will be necessary within the industry. New strategies and tools will have to be developed. These will require a significantly more integrated, holistically based and 'reflexive' approach than previously. The main elements of such an approach are outlined. With reference to the authors' ongoing research into automotive lead/acid starting lighting ignition (SLI) batteries, the paper shows how the technique of in-depth life cycle assessment (LCA), appropriately adapted to the needs of the industry, will provide a crucial role in this new approach. It also shows how it may be used as an internal design and assessment tool to identify those stages in the battery life cycle that give rise to the greatest environmental burdens, and to assess the effects of changes in the cycle to those burdens. It is argued that the development of this approach requires the serious and urgent attention of the whole of the lead industry. Also to make the LCA tool fully effective, it must be based on a 'live' database that is produced, maintained and continually updated by the industry.

  7. Glycosaminoglycan and transforming growth factor beta1 changes in human plasma and urine during the menstrual cycle, in vitro fertilization treatment, and pregnancy.

    Science.gov (United States)

    De Muro, Pierina; Capobianco, Giampiero; Formato, Marilena; Lepedda, Antonio Junior; Cherchi, Gian Mario; Gordini, Laila; Dessole, Salvatore

    2009-07-01

    To evaluate transforming growth factor beta1 (TGF-beta1) and glycosaminoglycans (GAG) changes in human plasma and urine during the menstrual cycle, IVF-ET, and pregnancy. Prospective clinical study. University hospital. Thirteen women with apparently normal menstrual cycle (group 1); 18 women undergoing IVF-ET (group 2); and 14 low-risk pregnant women (group 3). We assayed plasma and urine concentrations of TGF-beta1, urine content, and distribution of GAG. Blood and urine samples were collected during days 2 to 3, 12 to 13, and 23 to 24 in group 1; in group 2, samples were obtained at menstrual phase, oocyte pick-up day, and 15 days after ET; in group 3, samples were obtained during gestational weeks 10-12, 22-24, and 30-32 and 1 month after delivery. Changes in TGF-beta1 and GAG content. The mean value of total urinary trypsin inhibitor/chondroitin sulfate (UTI/CS) showed a distinct peak at day 12 of the menstrual cycle in the fertile women in whom we monitored the ovulatory period. In the IVF-ET group, GAG distribution and TGF-beta1 levels showed significant differences during the cycle. We observed increased levels of plasma TGF-beta1 15 days after ET. A significant increase of total UTI/CS value with increasing gestation was detected. Transforming growth factor beta1 and GAG levels could represent an additional tool to monitor reproductive events and could be useful, noninvasive markers of ovulation and ongoing pregnancy.

  8. Influence of the light factor on the course of the cell cycle in the successive generations of the antheridial filaments of Chara vulgaris L.

    Directory of Open Access Journals (Sweden)

    J. Maszewski

    2015-01-01

    Full Text Available The exposure to continuous light causes a rise of the mitotic index in the successive generations of the antheridial filaments of Chara vulgaris, whereas culture in darkness leads to a considerable depression of mitosis, and if prolonged, to its complete cessation. Light reverses the effect of the depression of mitosis caused by darkness: in the 16-, and 32-cell generations mitotic activity reappeares as early as after 3 h, but in the 2-, 4-, and 8-cell generations only after 18 h. The size of the cells in the antheridial filaments of plants exposed to continuous illumination is larger as compared with the control material. After being kept in darkness the cells become smaller. The analysis of the size of the latter suggests the inhibition of growth in initial and final periods of interphase. In all generations continuous light reduces the duration of the cell cycle while darkness protracts it. The duration of S phase is similar in all generations of antheridial filaments (ca. 16 h and is not modified by the light conditions. Thus, the light factor seems to interfere mainly with G2 phase, and its role in the regulation of the cell cycle is correlated with the duration of this phase. The role of light in the kinetics of the cell cycle of the particular generations of antheridial filaments in Chara is discussed in the aspect of the nutritional requirements of cells, hormonal regulation and phytochrome.

  9. The interaction between menstrual cycle, Tumour Necrosis Factor alpha receptors and sex hormones in healthy non-obese women – results from an observational study

    Directory of Open Access Journals (Sweden)

    Paweł Rzymski

    2014-09-01

    Full Text Available There is growing evidence that TNF-alpha and its two receptors play an important role in hormonal regulation, metabolism, inflammation and cancer. The biological effects of TNF-alpha are mediated by two receptors, p55 and p75. The aim of this study was to analyze serum concentrations of p55 and p75 and hormonal status in healthy women during the normal menstrual cycle. Eight women aged 20–22 with regular menstrual cycles were scheduled for examination on 3[sup]rd[/sup] , 8[sup]th[/sup] , 14[sup]th[/sup] and 25[sup]th [/sup] day of their menstrual cycle. We only observed a positive correlation of p75 subunit with prolactin level (correlation coefficient 0.417; p=0.0116 and negative correlation with insulin level (correlation coefficient -0.35; p=0.032 and HOMA[sub]IR[/sub] insulin resistance index correlation coefficient 0.39; p=0.0185. Furthermore, a negative correlation of p55/p75 ratio with prolactin (correlation coefficient -0.42; p=0.0101 and a positive correlations of p55/p75 ratio with insulin level (correlation coefficient 0.43; p=0.008 and HOMA[sub]IR[/sub] insulin resistance factor correlation coefficient 0.45; p=0.0065 were found.

  10. Development of emission factors for motorcycles and shared auto-rickshaws using real-world driving cycle for a typical Indian city.

    Science.gov (United States)

    Adak, Prasenjit; Sahu, Ravi; Elumalai, Suresh Pandian

    2016-02-15

    Vehicular emission is one of the most important contributors of urban air pollution. To quantify the impact of traffic on urban air quality, it is necessary to quantify vehicular emission. In many cities of India, such as Dhanbad, shared auto-rickshaw is the pre-dominant mode of transportation. Indian Driving Cycle (IDC) and Modified Indian Driving Cycle (MIDC) are used for emission testing of motorcycles, shared auto-rickshaws and passenger cars in India for regulatory purposes. IDC used for motorcycles and shared auto-rickshaws does not recognize the difference in two vehicle classes in terms of driving pattern. In real world, shared auto-rickshaws, behave differently than motorcycles. To quantify the impact of shared auto-rickshaws on urban air quality accurately, emission factors (EFs) are required to derive from real-world driving cycles (DCs). In heterogeneous traffic, vehicles of one class affect the behavior of vehicles of other classes. To estimate the emissions from different vehicle classes accurately, EFs for motorcycles and passenger cars are also required to be revised. In this study, real-world DCs were developed for motorcycles, shared auto-rickshaws and passenger cars in Dhanbad. Developed DCs were used to calculate EFs for respective classes. Shared auto-rickshaws were found to have the highest deviation from EFs derived using IDC. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. USEtox - The UNEP-SETAC toxicity model: recommended characterisation factors for human toxicity and freshwater ecotoxicity in Life Cycle Impact Assessment

    DEFF Research Database (Denmark)

    Rosenbaum, Ralph K.; Bachmann, Till M; Gold, Lois S.

    2008-01-01

    , and (iii) to build a scientific consensus model from them, representing recommended practice. Methods. A chemical test set of 45 organics covering a wide range of property combinations was selected for this purpose. All models used this set. In three workshops, the model comparison participants identified......, defining a closed or open system environment, or nesting an urban box in a continental box. Discussion. The precision of the new characterisation factors (CFs) is within a factor of 100-1000 for human health and 10-100 for freshwater ecotoxicity of all other models compared to 12 orders of magnitude......Background, Aim and Scope. In 2005 a comprehensive comparison of LCIA toxicity characterisation models was initiated by the UNEP-SETAC Life Cycle Initiative, directly involving the model developers of CalTOX, IMPACT 2002, USES-LCA, BETR, EDIP, WATSON, and EcoSense. In this paper we describe...

  12. Life Cycle Building Carbon Emissions Assessment and Driving Factors Decomposition Analysis Based on LMDI—A Case Study of Wuhan City in China

    Directory of Open Access Journals (Sweden)

    Yuanyuan Gong

    2015-12-01

    Full Text Available Carbon emissions calculation at the sub-provincial level has issues in limited data and non-unified measurements. This paper calculated the life cycle energy consumption and carbon emissions of the building industry in Wuhan, China. The findings showed that the proportion of carbon emissions in the construction operation phase was the largest, followed by the carbon emissions of the indirect energy consumption and the construction material preparation phase. With the purpose of analyzing the contributors of the construction carbon emissions, this paper conducted decomposition analysis using Logarithmic Mean Divisia Index (LMDI. The results indicated that the increasing buidling area was the major driver of energy consumption and carbon emissions increase, followed by the behavior factor. Population growth and urbanization, to some extent, increased the carbon emissions as well. On the contrary, energy efficiency was the main inhibitory factor for reducing the carbon emissions. Policy implications in terms of low-carbon construction development were highlighted.

  13. Plasma levels of immune factors and sex steroids in the male seahorse Hippocampus erectus during a breeding cycle.

    Science.gov (United States)

    Lin, Tingting; Liu, Xin; Xiao, Dongxue; Zhang, Dong

    2017-06-01

    To better understand the endocrine- and immune-response pattern during reproduction in a fish species having parental care behaviors and also to accumulate the endocrine- and immune-related data for future explanations of the low reproductive efficiency in seahorse species, the variations of immune factors and sex steroids in the plasma of the male lined seahorse Hippocampus erectus at different breeding stages, i.e., pre-pregnancy, pregnancy (early, middle, and late periods), and post-pregnancy, were investigated in the present study. The immune factors included monocytes/leucocytes (M/L), leucocyte phagocytic rate (LPR), immunoglobulin M (Ig M), interleukin-2 (IL-2), interferon-α (IFN-α), and lysozyme (LZM). The sex steroids included testosterone (T), 11-ketotestosterone (11-KT), 11β-hydroxytestosterone (11β-OHT), 17α-methyltestosterone (17α-MT), 17β-estradiol (E2), and 17α-hydroxy-20β-dihydroprogesterone (17α-20β-P). Moreover, the immune metabolic activity of epithelium cells in the brood pouch at different breeding stages was also analyzed through ultrastructural observations of the abundance of cytoplasmic granules, mitochondria, endoplasmic reticulum, lysosomes, and exocytosis. The results show that a higher immune level was observed during pregnancy, particularly in the early and middle periods, and a lower immune level was noted during pre-pregnancy. Correspondingly, the epithelium cells in the brood pouch also showed a stronger immune metabolic activity during pregnancy and weaker activity during pre-pregnancy. Four sex steroids of T, 11β-OHT, 17α-MT, and E2 were higher during pre-pregnancy and lower during post-pregnancy, whereas 11-KT and 17α-20β-P, which were positively correlated with part immune factors, were higher during pregnancy. No negative correlations between sex steroids and immune factors were observed. In conclusion, the higher immune competence during pregnancy may indicate that parental care could improve immunity, which may

  14. Influence of Personal Factors on Sound Perception and Overall Experience in Urban Green Areas. A Case Study of a Cycling Path Highly Exposed to Road Traffic Noise

    Directory of Open Access Journals (Sweden)

    Francesco Aletta

    2018-05-01

    Full Text Available In contemporary urban design, green public areas play a vital role. They have great societal value, but if exposed to undue environmental noise their restorative potential might be compromised. On the other hand, research has shown that the presence of greenery can moderate noise annoyance in areas with high sound levels, while personal factors are expected to play an important role too. A cycling path bordered by vegetation, but highly exposed to road traffic noise, was here considered as a case study. A sound perception survey was submitted to participants on site and they were subsequently sorted into groups according to their noise sensitivity, visual attention and attitude towards greenery. The aim of this study was testing whether these three personal factors could affect their noise perception and overall experience of the place. Results showed that people highly sensitive to noise and more sceptical towards greenery’s potential as an environmental moderator reported worse soundscape quality, while visually attentive people reported better quality. These three personal factors were found to be statistically independent. This study shows that several person-related factors impact the assessment of the sound environment in green areas. Although the majority of the respondents benefit from the presence of visual green, policy-makers and planners should be aware that for a significant subset of the population, it should be accompanied by a tranquil soundscape to be fully appreciated.

  15. Influence of Personal Factors on Sound Perception and Overall Experience in Urban Green Areas. A Case Study of a Cycling Path Highly Exposed to Road Traffic Noise.

    Science.gov (United States)

    Aletta, Francesco; Van Renterghem, Timothy; Botteldooren, Dick

    2018-05-30

    In contemporary urban design, green public areas play a vital role. They have great societal value, but if exposed to undue environmental noise their restorative potential might be compromised. On the other hand, research has shown that the presence of greenery can moderate noise annoyance in areas with high sound levels, while personal factors are expected to play an important role too. A cycling path bordered by vegetation, but highly exposed to road traffic noise, was here considered as a case study. A sound perception survey was submitted to participants on site and they were subsequently sorted into groups according to their noise sensitivity, visual attention and attitude towards greenery. The aim of this study was testing whether these three personal factors could affect their noise perception and overall experience of the place. Results showed that people highly sensitive to noise and more sceptical towards greenery's potential as an environmental moderator reported worse soundscape quality, while visually attentive people reported better quality. These three personal factors were found to be statistically independent. This study shows that several person-related factors impact the assessment of the sound environment in green areas. Although the majority of the respondents benefit from the presence of visual green, policy-makers and planners should be aware that for a significant subset of the population, it should be accompanied by a tranquil soundscape to be fully appreciated.

  16. Production of transforming growth factor α in human pancreatic cancer cells: evidence for a superagonist autocrine cycle

    International Nuclear Information System (INIS)

    Smith, J.J.; Derynck, R.; Korc, M.

    1987-01-01

    Previous work showed that cultured human pancreatic cancer cells overexpress the epidermal growth factor (EGF) receptor. In the present study, the authors sought to determine whether some of these cell lines produce transforming growth factor α (TGF-α). Utilizing a radiolabeled TGF-α cDNA in hybridization experiments, they determined that ASPC-1, T 3 M 4 , PANC-1, COLO-357, and MIA PaCa-2 cell lines expressed TGF-α mRNA. Serum-free medium conditioned by T 3 M 4 and ASPC-1 cells contained significant amounts of TGF-α protein. Although unlabeled TGF-α readily competed with 125 I-labeled EGF for binding, each cell line exhibited lower surface binding and internalization of 125 I-labeled TGF-α as compared to 125 I-labeled EGF. Both TGF-α and EGF significantly enhanced the anchorage-independent growth of PANC-1, T 3 M 4 , and ASPC-1 cells. However, TGF-α was 10- to 100-fold more potent than EGF. These findings suggest that the concomitant overexpression of EGF receptors and production of TGF-α may represent an efficient mechanism for certain cancer cells to obtain a growth advantage

  17. Characteristics of utility cyclists in Queensland, Australia: an examination of the associations between individual, social, and environmental factors and utility cycling.

    Science.gov (United States)

    Sahlqvist, Shannon L; Heesch, Kristiann C

    2012-08-01

    Initiatives to promote utility cycling in countries like Australia and the US, which have low rates of utility cycling, may be more effective if they first target recreational cyclists. This study aimed to describe patterns of utility cycling and examine its correlates, among cyclists in Queensland, Australia. An online survey was administered to adult members of a state-based cycling community and advocacy group (n=1813). The survey asked about demographic characteristics and cycling behavior, motivators and constraints. Utility cycling patterns were described, and logistic regression modeling was used to examine associations between utility cycling and other variables. Forty-seven percent of respondents reported utility cycling: most did so to commute (86%). Most journeys (83%) were >5 km. Being male, younger, employed full-time, or university-educated increased the likelihood of utility cycling (P<.05). Perceiving cycling to be a cheap or a convenient form of transport was associated with utility cycling (P<.05). The moderate rate of utility cycling among recreational cyclists highlights a potential to promote utility cycling among this group. To increase utility cycling, strategies should target female and older recreational cyclists and focus on making cycling a cheap and convenient mode of transport.

  18. Sulfur cycle

    Digital Repository Service at National Institute of Oceanography (India)

    LokaBharathi, P.A.

    Microbes, especially bacteria, play an important role in oxidative and reductive cycle of sulfur. The oxidative part of the cycle is mediated by photosynthetic bacteria in the presence of light energy and chemosynthetic forms in the absence of light...

  19. Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing: observational longitudinal cohort study of 1,219 consecutive cycles.

    Science.gov (United States)

    Mazzilli, Rossella; Cimadomo, Danilo; Vaiarelli, Alberto; Capalbo, Antonio; Dovere, Lisa; Alviggi, Erminia; Dusi, Ludovica; Foresta, Carlo; Lombardo, Francesco; Lenzi, Andrea; Tournaye, Herman; Alviggi, Carlo; Rienzi, Laura; Ubaldi, Filippo Maria

    2017-12-01

    To evaluate the impact of the male factor on the outcomes of intracytoplasmic sperm injection (ICSI) cycles combined with preimplantation genetic testing for aneuploidies (PGT-A). Observational longitudinal cohort study. Private in vitro fertilization (IVF) center. A total of 1,219 oocyte retrievals divided into five study groups according to sperm parameters: normozoospermia (N), moderate male factor (MMF), severe oligoasthenoteratozoospermia (OAT-S), obstructive azoospermia (OA), and nonobstructive azoospermia (NOA). ICSI with ejaculated/surgically retrieved sperm, blastocyst culture, trophectoderm-based quantitative polymerase chain reaction PGT-A, and frozen-warmed euploid embryo transfer (ET). The primary outcome measures were fertilization, blastocyst development, and euploidy rates; the secondary outcome measures were live birth and miscarriage rates. Perinatal and obstetrical outcomes were monitored as well. A total of 9,042 metaphase II oocytes were inseminated. The fertilization rate was significantly reduced in MMF, OAT-S, OA, and NOA compared with N (74.8%, 68.7%, 67.3%, and 53.1% vs. 77.2%). The blastocyst rate per fertilized oocyte was significantly reduced in MMF and NOA compared with N (48.6% and 40.6% vs. 49.3%). The timing of blastocyst development also was affected in OA and NOA. Logistic regression analysis adjusted for confounders highlighted NOA as a negative predictor of obtaining an euploid blastocyst per OPU (odds ratio 0.5). When the analysis was performed per obtained blastocyst, however, no correlation between male factor and euploidy rate was observed. Embryo transfers also resulted in similar live birth and miscarriage rates. No impact of sperm factor on obstetrical/perinatal outcomes was observed. Severe male factor impairs early embryonic competence in terms of fertilization rate and developmental potential. However, the euploidy rate and implantation potential of the obtained blastocysts are independent from sperm quality

  20. Prognostic Markers in Core-Binding Factor AML and Improved Survival with Multiple Consolidation Cycles of Intermediate/High-dose Cytarabine.

    Science.gov (United States)

    Prabahran, Ashvind; Tacey, Mark; Fleming, Shaun; Wei, Andrew; Tate, Courtney; Marlton, Paula; Wight, Joel; Grigg, Andrew; Tuckfield, Annabel; Szer, Jeff; Ritchie, David; Chee, Lynette

    2018-05-02

    Core-binding factor acute myeloid leukaemia (CBF AML) defined by t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22) has a favourable prognosis, however 30-40% of patients still relapse after chemotherapy. We sought to evaluate risk factors for relapse in a de novo CBF AML cohort. A retrospective review of patients from 4 Australian tertiary centres from 2001-2012, comprising 40 t(8;21) and 30 inv(16) AMLs. Multivariate analysis identified age (p=0.032) and WCC>40 (p=0.025) as significant predictors for inferior OS and relapse respectively. Relapse risk was higher in the inv(16) group vs the t(8;21) group (57% vs 18%, HR 4.31, 95% CI: 1.78-10.42, p=0.001). Induction therapy had no bearing on OS or relapse free survival (RFS) however, consolidation treatment with >3 cycles of intermediate/high dose cytarabine improved OS (p=0.035) and relapse-free survival (RFS) (p=0.063). 5 patients demonstrated post-treatment stable q PCR positivity without relapse. (1)>3 consolidation cycles of intermediate/ high-dose cytarabine improves patient outcomes. (2)Age and inv(16) CBF AML subtype are predictors of inferior OS and RFS respectively. (3)Stable low-level MRD by qPCR does not predict relapse. (4)Similar OS in the inv(16) cohort compared to the t(8;21) cohort, despite a higher relapse rate, confirms salvageability of relapsed disease. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  1. Letrozole in a low-cost in vitro fertilization protocol in intracytoplasmic sperm injection cycles for male factor infertility: A randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Shiuli Mukherjee

    2012-01-01

    Full Text Available Introduction: Letrozole, a selective aromatase inhibitor, reduces the total dose of gonadotrophin required for inducing follicular maturation. We evaluated if incorporation of letrozole could be an effective alternative for low-cost in vitro fertilization (IVF protocol particularly in intracytoplasmic sperm injection (ICSI cycles where male factor infertility is the sole indication for IVF. Materials and Methods: It is a randomized controlled single-blind trial. 94 women with history of severe male factor infertility were selected. 42 women (study group received letrozole, 5 mg daily from day 3-7 and recombinant FSH (rFSH 75IU/day from day 5 continuously till hCG injection. 52 women (control group underwent continuous stimulation by rFSH (150-225IU/day from day 2. GnRH-antagonist (Inj. Orgalutran 0.25 ml sub-cutaneous was started at maximum follicle size of 14 in both groups. Ovulation was triggered by 10,000IU of hCG followed by IVF-ET. Main outcome measures were total dose of rFSH (IU/cycle, terminal E2 (pg/ml, number of mature follicles, number of oocyte retrieved, transferable embryo, endometrial thickness, pregnancy rate and mean expenditure. Statistical analysis is done by using SPSS11. Results :0 As compared to control group (1756 ± 75IU, the study group i.e., Let-rFSH received (625 ± 98IU significantly lower (P = 0.0001 total dose of rFSH. Terminal E2 was significantly lower (P = 0.0001 in study group than control (830 ± 36 vs. 1076 ± 41 pg/ml with significant increment in endometrial thickness (P = 0.0008 in study group, (9.1 ± 0.32 vs. 8.7 ± 0.69 which maintained an improved pregnancy rate though nonsignificant. The risk of hyperstimulation had significantly (P = 0.01 reduced in study group than control (0 vs. 7.Treatment outcome in all other aspects including pregnancy rate were statistically comparable. Per cycle mean expenditure was reduced by 34% in study group than control. Conclusion: Adjunctive use of letrozole may be an

  2. Using a combination of weighting factor method and imperialist competitive algorithm to improve speed and enhance process of reloading pattern optimization of VVER-1000 reactors in transient cycles

    Energy Technology Data Exchange (ETDEWEB)

    Rahmani, Yashar, E-mail: yashar.rahmani@gmail.com [Department of Physics, Faculty of Engineering, Islamic Azad University, Sari Branch, Sari (Iran, Islamic Republic of); Shahvari, Yaser [Department of Computer Engineering, Payame Noor University (PNU), P.O. Box 19395-3697, Tehran (Iran, Islamic Republic of); Kia, Faezeh [Golestan Institute of Higher Education, Gorgan 49139-83635 (Iran, Islamic Republic of)

    2017-03-15

    Highlights: • This article was an attempt to optimize reloading pattern of Bushehr VVER-1000 reactor. • A combination of weighting factor method and the imperialist competitive algorithm was used. • The speed of optimization and desirability of the proposed pattern increased considerably. • To evaluate arrangements, a coupling of WIMSD5-B, CITATION-LDI2 and WERL codes was used. • Results reflected the considerable superiority of the proposed method over direct optimization. - Abstract: In this research, an innovative solution is described which can be used with a combination of the new imperialist competitive algorithm and the weighting factor method to improve speed and increase globality of search in reloading pattern optimization of VVER-1000 reactors in transient cycles and even obtain more desirable results than conventional direct method. In this regard, to reduce the scope of the assumed searchable arrangements, first using the weighting factor method and based on values of these coefficients in each of the 16 types of loadable fuel assemblies in the second cycle, the fuel assemblies were classified in more limited groups. In consequence, the types of fuel assemblies were reduced from 16 to 6 and consequently the number of possible arrangements was reduced considerably. Afterwards, in the first phase of optimization the imperialist competitive algorithm was used to propose an optimum reloading pattern with 6 groups. In the second phase, the algorithm was reused for finding desirable placement of the subset assemblies of each group in the optimum arrangement obtained from the previous phase, and thus the retransformation of the optimum arrangement takes place from the virtual 6-group mode to the real mode with 16 fuel types. In this research, the optimization process was conducted in two states. In the first state, it was tried to obtain an arrangement with the maximum effective multiplication factor and the smallest maximum power peaking factor. In

  3. Cancer cell-soluble factors reprogram mesenchymal stromal cells to slow cycling, chemoresistant cells with a more stem-like state

    Directory of Open Access Journals (Sweden)

    Ahmed El-Badawy

    2017-11-01

    Full Text Available Abstract Background Mesenchymal stem cells (MSCs play different roles in modulating tumor progression, growth, and metastasis. MSCs are recruited to the tumor site in large numbers and subsequently have an important microenvironmental role in modulating tumor progression and drug sensitivity. However, the effect of the tumor microenvironment on MSC plasticity remains poorly understood. Herein, we report a paracrine effect of cancer cells, in which they secrete soluble factors that promote a more stem-like state in bone marrow mesenchymal stem cells (BM-MSCs. Methods The effect of soluble factors secreted from MCF7, Hela, and HepG2 cancer cell lines on BM-MSCs was assessed using a Transwell indirect coculture system. After 5 days of coculture, BM-MSCs were characterized by flow cytometry for surface marker expression, by qPCR for gene expression profile, and by confocal immunofluorescence for marker expression. We then measured the sensitivity of cocultured BM-MSCs to chemotherapeutic agents, their cell cycle profile, and their response to DNA damage. The sphere formation, invasive properties, and in-vivo performance of BM-MSCs after coculture with cancer cells were also measured. Results Indirect coculture of cancer cells and BM-MSCs, without direct cell contact, generated slow cycling, chemoresistant spheroid stem cells that highly expressed markers of pluripotency, cancer cells, and cancer stem cells (CSCs. They also displayed properties of a side population and enhanced sphere formation in culture. Accordingly, these cells were termed cancer-induced stem cells (CiSCs. CiSCs showed a more mesenchymal phenotype that was further augmented upon TGF-β stimulation and demonstrated a high expression of the β-catenin pathway and ALDH1A1. Conclusions These findings demonstrate that MSCs, recruited to the tumor microenvironment in large numbers, may display cellular plasticity, acquire a more stem-like state, and acquire some properties of CSCs upon

  4. Serum dehydroepiandrosterone sulphate concentration is not a predictive factor in IVF outcomes before the first cycle of GnRH agonist administration in women with normal ovarian reserve.

    Directory of Open Access Journals (Sweden)

    Michał Kunicki

    Full Text Available The aim of our study was to determine whether serum dehydroepiandrosterone sulphate (DHEAS concentration and the models incorporating it could help clinicians to predict IVF outcomes in women with normal ovarian reserve undergoing their first long protocol.We performed a retrospective analysis of 459 women undergoing cycles of intracytoplasmic sperm injection (ICSI for the first time in a long GnRH agonist protocol.Embryo transfer was performed in 407 women (88.7%. The fertilisation rate was 78.6%. The clinical pregnancy rate was 44.8% per started cycle and 50.6% per embryo transfer. Our univariate model revealed that the best predictors of clinical pregnancy were the number of mature oocytes, the number of embryos transferred and the number of good quality embryos, account for the clinical parameters that reflect ovarian reserve the best being AMH level and AFC. DHEAS did not predict clinical pregnancy (OR 1.001, 95% CI, 0.999-1.004. After adjusting for the number of embryos transferred and class of embryos in a multivariate model, the best predictors were age (OR 0.918, 95% CI, 0.867-0.972 and AFC (OR 1.022, 95% CI, 0.992-1.053. Serum DHEAS levels were positively correlated with AFC (r = 0.098, P<0.039 and testosterone levels (r = 0.371, P<0.001, as well as the number of mature oocytes (r = 0.109, P<0.019; serum DHEAS levels were negatively correlated with age (r = -0.220, P<0.001, follicle-stimulating hormone (FSH, (r = -0.116, P<0.015 and sex hormone-binding globulin (SHBG, (r = -0.193, P<0.001.DHEAS concentration (in addition to the known factors of ovarian reserve does not predict clinical pregnancy in women with normal ovarian reserve who are undergoing ICSI.

  5. How well can business cycle accounting account for business cycles?

    OpenAIRE

    Keisuke Otsu

    2012-01-01

    The business cycle accounting method introduced by Chari, Kehoe and McGrattan (2007) is a useful tool to decompose business cycle fluctuations into their contributing factors. However, the model estimated by the maximum likelihood method cannot replicate business cycle moments computed from data. Moment-based estimation might be an attractive alternative if the purpose of the research is to study business cycle properties such as volatility, persistence and cross-correlation of variables inst...

  6. Placental macrophage contact potentiates the complete replicative cycle of human cytomegalovirus in syncytiotrophoblast cells: role of interleukin-8 and transforming growth factor-beta1.

    Science.gov (United States)

    Bácsi, A; Aranyosi, J; Beck, Z; Ebbesen, P; Andirkó, I; Szabó, J; Lampé, L; Kiss, J; Gergely, L; Tóth, F D

    1999-10-01

    Although syncytiotrophoblast (ST) cells can be infected by human cytomegalovirus (HCMV), in vitro studies have indicated that ST cells do not support the complete viral reproductive cycle, or HCMV replication may occur in less than 3% of ST cells. The present study tested the possibility that placental macrophages might enhance activation of HCMV carried in ST cells and, further, that infected ST cells would be capable of transmitting virus to neighboring macrophages. For this purpose, we studied HCMV replication in ST cells grown alone or cocultured with uninfected placental macrophages. Our results demonstrated that HCMV gene expression in ST cells was markedly upregulated by coculture with macrophages, resulting in release of substantial amounts of infectious virus from HCMV-infected ST cells. After having become permissive for viral replication, ST cells delivered HCMV to the cocultured macrophages, as evidenced by detection of virus-specific antigens in these cells. The stimulatory effect of coculture on HCMV gene expression in ST cells was mediated by marked interleukin-8 (IL-8) and transforming growth factor-beta1 (TGF-beta1) release from macrophages, an effect caused by contact between the different placental cells. Our findings indicate an interactive role for the ST layer and placental macrophages in the dissemination of HCMV among placental tissue. Eventually, these interactions may contribute to the transmission of HCMV from mother to the fetus.

  7. Glacial cycles

    DEFF Research Database (Denmark)

    Kaufmann, R. K.; Juselius, Katarina

    We use a statistical model, the cointegrated vector autoregressive model, to assess the degree to which variations in Earth's orbit and endogenous climate dynamics can be used to simulate glacial cycles during the late Quaternary (390 kyr-present). To do so, we estimate models of varying complexity...... and compare the accuracy of their in-sample simulations. Results indicate that strong statistical associations between endogenous climate variables are not enough for statistical models to reproduce glacial cycles. Rather, changes in solar insolation associated with changes in Earth's orbit are needed...... to simulate glacial cycles accurately. Also, results suggest that non-linear 10 dynamics, threshold effects, and/or free oscillations may not play an overriding role in glacial cycles....

  8. Fuel cycles

    International Nuclear Information System (INIS)

    Hawley, N.J.

    1983-05-01

    AECL publications, from the open literature, on fuels and fuel cycles used in CANDU reactors are listed in this bibliography. The accompanying index is by subject. The bibliography will be brought up to date periodically

  9. Effects of an endurance cycling competition on resting serum insulin-like growth factor I (IGF-I) and its binding proteins IGFBP-1 and IGFBP-3

    Science.gov (United States)

    Chicharro, J; Lopez-Calderon, A; Hoyos, J; Martin-Velasco, A; Villa, G; Villanua, M; Lucia, A

    2001-01-01

    Objectives—To determine whether consecutive bouts of intense endurance exercise over a three week period alters serum concentrations of insulin-like growth factor I (IGF-I) and/or its binding proteins. Methods—Seventeen professional cyclists (mean (SEM) VO2MAX, 74.7 (2.1) ml/kg/min; age, 27 (1) years) competing in a three week tour race were selected as subjects. Blood samples were collected at each of the following time points: t0 (control, before the start of competition), t1 (end of first week), and t3 (end of third week). Serum levels of both total and free IGF-I and IGF binding proteins 1 and 3 (IGFBP-1 and IGFBP-3) were measured in each of the samples. Cortisol levels were measured in nine subjects. Results—A significant (p<0.01) increase was found in total IGF-I and IGFBP-1 at both t1 and t3 compared with to (IGF-I: 110.9 (17.7), 186.8 (12.0), 196.9 (14.7) ng/ml at t0, t1, and t3 respectively; IGFBP-1: 54.6 (6.6), 80.6 (8.0), and 89.2 (7.9) ng/ml at t0, t1, and t3 respectively). A significant (p<0.01) decrease was noted in free IGF-I at t3 compared with both to and t1 (t0: 0.9 (0.1) ng/ml; t1: 0.9 (0.1) ng/ml; t3: 0.7 (0.1) ng/ml); in contrast, IGFBP-3 levels remained stable throughout the race. Conclusions—It would appear that the increase in circulating levels of both IGF-I and its binding protein IGFBP-1 is a short term (one week) endocrine adaptation to endurance exercise. After three weeks of training, total IGF-I and IGFBP-1 remained stable, whereas free IGF-I fell below starting levels. Key Words: cycling; insulin-like growth factor; exercise; endurance; binding proteins PMID:11579061

  10. Future fuel cycles

    International Nuclear Information System (INIS)

    Archinoff, G.H.

    1980-01-01

    A fuel cycle must offer both financial and resource savings if it is to be considered for introduction into Ontario's nuclear system. The most promising alternative CANDU fuel cycles are examined in the context of both of these factors over a wide range of installed capacity growth rates and economic assumptions, in order to determine which fuel cycle, or cycles, should be introduced, and when. It is concluded that the optimum path for the long term begins with the prompt introduction of the low-enriched-uranium fuel cycle. For a wide range of conditions, this cycle remains the optimum throughout the very long term. Conditions of rapid nuclear growth and very high uranium price escalation rates warrant the supersedure of the low-enriched-uranium cycle by either a plutonium-topped thorium cycle or plutonium recycle, beginning between 2010 and 2025. It is also found that the uranium resource position is sound in terms of both known resources and production capability. Moreover, introduction of the low-enriched-uranium fuel cycle and 1250 MWe reactor units will assure the economic viability of nuclear power until at least 2020, even if uranium prices increase at a rate of 3.5% above inflation. The interrelationship between these two conclusions lies in the tremendous incentive for exploration which will occur if the real uranium price escalation rate is high. From a competitive viewpoint, nuclear power can withstand increases in the price of uranium. However, such increases will likely further expand the resource base, making nuclear an even more reliable energy source. (auth)

  11. Skills, sunspots and cycles

    DEFF Research Database (Denmark)

    Busato, Francesco; Marchetti, Enrico

    This paper explores the ability of a class of one-sector,multi-input models to generate indeterminate equilibrium paths, andendogenous cycles, without relying on factors' hoarding. The modelpresents a novel theoretical economic mechanism that supportssunspot-driven expansions without requiring...

  12. Coordination cycles

    Czech Academy of Sciences Publication Activity Database

    Steiner, Jakub

    -, č. 274 (2005), s. 1-26 ISSN 1211-3298 Institutional research plan: CEZ:AV0Z70850503 Keywords : coordination * crises * cycles and fluctuations Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp274.pdf

  13. Happy Cycling

    DEFF Research Database (Denmark)

    Geert Jensen, Birgitte; Nielsen, Tom

    2013-01-01

    og Interaktions Design, Aarhus Universitet under opgave teamet: ”Happy Cycling City – Aarhus”. Udfordringen i studieopgaven var at vise nye attraktive løsningsmuligheder i forhold til cyklens og cyklismens integration i byrum samt at påpege relationen mellem design og overordnede diskussioner af...

  14. The human RNA polymerase II-associated factor 1 (hPaf1: a new regulator of cell-cycle progression.

    Directory of Open Access Journals (Sweden)

    Nicolas Moniaux

    2009-09-01

    Full Text Available The human PAF (hPAF complex is part of the RNA polymerase II transcription apparatus and regulates multiple steps in gene expression. Further, the yeast homolog of hPaf1 has a role in regulating the expression of a subset of genes involved in the cell-cycle. We therefore investigated the role of hPaf1 during progression of the cell-cycle.Herein, we report that the expression of hPaf1, a subunit of the hPAF complex, increases with cell-cycle progression and is regulated in a cell-cycle dependant manner. hPaf1 specifically regulates a subclass of genes directly implicated in cell-cycle progression during G1/S, S/G2, and G2/M. In prophase, hPaf1 aligns in filament-like structures, whereas in metaphase it is present within the pole forming a crown-like structure, surrounding the centrosomes. Moreover, hPaf1 is degraded during the metaphase to anaphase transition. In the nucleus, hPaf1 regulates the expression of cyclins A1, A2, D1, E1, B1, and Cdk1. In addition, expression of hPaf1 delays DNA replication but favors the G2/M transition, in part through microtubule assembly and mitotic spindle formation.Our results identify hPaf1 and the hPAF complex as key regulators of cell-cycle progression. Mutation or loss of stoichiometry of at least one of the members may potentially lead to cancer development.

  15. Fuel cycle

    International Nuclear Information System (INIS)

    Bahm, W.

    1989-01-01

    The situation of the nuclear fuel cycle for LWR type reactors in France and in the Federal Republic of Germany was presented in 14 lectures with the aim to compare the state-of-the-art in both countries. In addition to the momentarily changing fuilds of fuel element development and fueling strategies, the situation of reprocessing, made interesting by some recent developmnts, was portrayed and differences in ultimate waste disposal elucidated. (orig.) [de

  16. The benefits of longer fuel cycle lengths

    International Nuclear Information System (INIS)

    Kesler, D.C.

    1986-01-01

    Longer fuel cycle lengths have been found to increase generation and improve outage management. A study at Duke Power Company has shown that longer fuel cycles offer both increased scheduling flexibility and increased capacity factors

  17. Associations between urban form and cycling

    DEFF Research Database (Denmark)

    Nielsen, Thomas Alexander Sick; Olafsson, Anton Stahl; Carstensen, Trine Agervig

    of National Travel Survey data indicated that established walkability factors such as density, connectivity and diversity are related to cycling, and that access to retail concentrations/centres, public transportation level-of-service, as well as competition between walking and cycling depending...... of cycling and the distance cycled. A high probability of cycling generally implies short cycling distances, which leads to non-uniform, non-monotonous relations between environmental indicators such as walkability and total cycling. Further analysis of primary data allowing a consideration of attitudes...

  18. Distribution of epidermal growth factor receptors in rat tissues during embryonic skin development, hair formation, and the adult hair growth cycle

    DEFF Research Database (Denmark)

    Green, M R; Couchman, J R

    1984-01-01

    on the binding distribution of [125I]EGF, representing the tissue localization of available EGF receptors, during embryonic rat skin development including hair follicle formation and the adult hair growth cycle. At 16 days embryonic development a relatively low receptor density is seen over all the epidermal...... condensates marking the first stage of hair follicle development. This restricted and temporary loss of EGF receptors above these specialized mesenchymal condensates implies a role for the EGF receptor and possibly EGF or an EGF-like ligand in stimulating the epithelial downgrowth required for hair follicle...... development. In the anagen hair bulb, receptors for EGF are detected over the outer root sheath and the epithelial cell layers at the base of the follicle and show a correlation with the areas of epithelial proliferation in the hair bulb. During the catagen and telogen phases of the hair cycle, receptors...

  19. Influence of spatially dependent, modeled soil carbon emission factors on life-cycle greenhouse gas emissions of corn and cellulosic ethanol

    Energy Technology Data Exchange (ETDEWEB)

    Qin, Zhangcai [Energy Systems Division, Argonne National Laboratory, 9700 South Cass Avenue Argonne IL 60439 USA; Dunn, Jennifer B. [Energy Systems Division, Argonne National Laboratory, 9700 South Cass Avenue Argonne IL 60439 USA; Kwon, Hoyoung [Environment and Production Technology Division, International Food Policy Research Institute, 2033 K St. NW Washington DC 20006 USA; Mueller, Steffen [Energy Resources Center, University of Illinois at Chicago, 1309 South Halsted Street Chicago IL 60607 USA; Wander, Michelle M. [Department of Natural Resources and Environmental Sciences, University of Illinois at Urbana-Champaign, 1102 South Goodwin Avenue Urbana IL 61801 USA

    2016-03-03

    Converting land to biofuel feedstock production incurs changes in soil organic carbon (SOC) that can influence biofuel life-cycle greenhouse gas (GHG) emissions. Estimates of these land use change (LUC) and life-cycle GHG emissions affect biofuels’ attractiveness and eligibility under a number of renewable fuel policies in the U.S. and abroad. Modeling was used to refine the spatial resolution and depth-extent of domestic estimates of SOC change for land (cropland, cropland pasture, grasslands, and forests) conversion scenarios to biofuel crops (corn, corn stover, switchgrass, Miscanthus, poplar, and willow). In most regions, conversions from cropland and cropland pasture to biofuel crops led to neutral or small levels of SOC sequestration, while conversion of grassland and forest generally caused net SOC loss. Results of SOC change were incorporated into the Greenhouse Gases, Regulated Emissions, and Energy use in Transportation (GREET) model to assess their influence on life-cycle GHG emissions for the biofuels considered. Total LUC GHG emissions (g CO2eq MJ-1) were 2.1–9.3 for corn, -0.7 for corn stover, -3.4–12.9 for switchgrass, and -20.1–-6.2 for Miscanthus; these varied with SOC modeling assumptions applied. Extending soil depth from 30 to 100cm affected spatially-explicit SOC change and overall LUC GHG emissions; however the influence on LUC GHG emissions estimates were less significant in corn and corn stover than cellulosic feedstocks. Total life-cycle GHG emissions (g CO2eq MJ-1, 100cm) were estimated to be 59–66 for corn ethanol, 14 for stover ethanol, 18-26 for switchgrass ethanol, and -0.6–-7 for Miscanthus ethanol.

  20. Analysis of environmental factors impacting the life cycle cost analysis of conventional and fuel cell/battery-powered passenger vehicles. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-01-31

    This report presents the results of the further developments and testing of the Life Cycle Cost (LCC) Model previously developed by Engineering Systems Management, Inc. (ESM) on behalf of the U.S. Department of Energy (DOE) under contract No. DE-AC02-91CH10491. The Model incorporates specific analytical relationships and cost/performance data relevant to internal combustion engine (ICE) powered vehicles, battery powered electric vehicles (BPEVs), and fuel cell/battery-powered electric vehicles (FCEVs).

  1. Safe cycling!

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    The HSE Unit will be running a cycling safety campaign at the entrances to CERN's restaurants on 14, 15 and 16 May. Pop along to see if they can persuade you to get back in the saddle!   With summer on its way, you might feel like getting your bike out of winter storage. Well, the HSE Unit has come up with some original ideas to remind you of some of the most basic safety rules. This year, the prevention campaign will be focussing on three themes: "Cyclists and their equipment", "The bicycle on the road", and "Other road users". This is an opportunity to think about the condition of your bike as well as how you ride it. From 14 to 16 May, representatives of the Swiss Office of Accident Prevention and the Touring Club Suisse will join members of the HSE Unit at the entrances to CERN's restaurants to give you advice on safe cycling (see box). They will also be organising three activity stands where you can test your knowle...

  2. Cycle 22

    International Nuclear Information System (INIS)

    Kappernman, J.G.; Albertson, V.D.

    1991-01-01

    This paper reports that for many electric utility systems, Solar Cycle 22 has been the first introduction to the phenomena of Geomagnetic Disturbances and the disrupting and damaging effects that they can have upon modern power systems. For all intents and purposes, Power Industry awareness of Cycle 22 started with a bang during the Great Geomagnetic Storm of March 13, 1989. This storm caused a blackout to the entire Province of Quebec, permanently damaged a large nuclear plant GSU transformer in New Jersey, and created enough havoc across the entire North American power grid to create the plausible threat of a massive power system blackout. The flurry of activity and investigation that followed has led many engineers to realize that their power systems are indeed vulnerable to this phenomena and if anything are becoming ever more vulnerable as the system grows to meet future requirements. As a result some organizations such as Hydro Quebec, PSE and G, and the PJM Pool now implement strategic measures as a remedial response to detection of geomagnetic storm conditions. Many more companies pay particularly close attention to storm forecasts and alerts, and the industry in general has accelerated research and monitoring activities through their own means of in concert with the Electric Power Research Institute (EPRI)

  3. The evolving nuclear fuel cycle

    International Nuclear Information System (INIS)

    Gale, J.D.; Hanson, G.E.; Coleman, T.A.

    1993-01-01

    Various economics and political pressures have shaped the evolution of nuclear fuel cycles over the past 10 to 15 yr. Future trends will no doubt be similarly driven. This paper discusses the influences that long cycles, high discharge burnups, fuel reliability, and costs will have on the future nuclear cycle. Maintaining the economic viability of nuclear generation is a key issue facing many utilities. Nuclear fuel has been a tremendous bargain for utilities, helping to offset major increases in operation and maintenance (O ampersand M) expenses. An important factor in reducing O ampersand M costs is increasing capacity factor by eliminating outages

  4. Forests and water cycle

    Directory of Open Access Journals (Sweden)

    Iovino F

    2009-06-01

    Full Text Available Based on a comprehensive literature analysis, a review on factors that control water cycle and water use in Mediterranean forest ecosystems is presented, including environmental variables and silvicultural treatments. This important issue is considered in the perspective of sustainable forest management of Mediterranean forests, with special regard to crucial environmental hazards such as forest fires and desertification risks related to climate change.

  5. Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts

    International Nuclear Information System (INIS)

    Chang, J.-K.; Li, C.-J.; Liao, H.-J.; Wang, C.-K.; Wang, G.-J.; Ho, M.-L.

    2009-01-01

    It has been reported that anti-inflammatory drugs (AIDs) inhibited bone repair in animal studies, and suppressed proliferation and induced cell death in rat osteoblast cultures. In this study, we further investigated the molecular mechanisms of AID effects on proliferation and cell death in human osteoblasts (hOBs). We examined the effects of dexamethasone (10 -7 and 10 -6 M), non-selective non-steroidal anti-inflammatory drugs (NSAIDs): indomethacin, ketorolac, piroxicam and diclofenac (10 -5 and 10 -4 M), and COX-2 inhibitor: celecoxib (10 -6 and 10 -5 M) on proliferation, cytotoxicity, cell death, and mRNA and protein levels of cell cycle and apoptosis-related regulators in hOBs. All the tested AIDs significantly inhibited proliferation and arrested cell cycle at G0/G1 phase in hOBs. Celecoxib and dexamethasone, but not non-selective NSAIDs, were found to have cytotoxic effects on hOB, and further demonstrated to induce apoptosis and necrosis (at higher concentration) in hOBs. We further found that indomethacin, celecoxib and dexamethasone increased the mRNA and protein expressions of p27 kip1 and decreased those of cyclin D2 and p-cdk2 in hOBs. Bak expression was increased by celecoxib and dexamethasone, while Bcl-XL level was declined only by dexamethasone. Furthermore, the replenishment of PGE1, PGE2 or PGF2α did not reverse the effects of AIDs on proliferation and expressions of p27 kip1 and cyclin D2 in hOBs. We conclude that the changes in expressions of regulators of cell cycle (p27 kip1 and cyclin D2) and/or apoptosis (Bak and Bcl-XL) by AIDs may contribute to AIDs caused proliferation suppression and apoptosis in hOBs. This effect might not relate to the blockage of prostaglandin synthesis by AIDs

  6. Emission of toxic components as a factor of the best practice options for waste management: Application of LCA (Life Cycle Assessment

    Directory of Open Access Journals (Sweden)

    Stevanović-Čarapina Hristina D.

    2011-01-01

    Full Text Available Health and safety have been the major concerns in waste management. Waste must be managed in a way that minimizes risk to human health. Environmental concerns over the management and disposal of waste can be divided into two major areas: conservation of resources and pollution of the environment. Integrated Waste Management (IWM systems combine waste streams, waste collection, treatment and disposal methods, with the objective of achieving environmental benefits, economic optimization and societal acceptability. Integrated waste management using Life Cycle Assessment (LCA attempts to offer the most benign options for waste management. LCA is a compilation and evaluation of the inputs, the outputs and the potential environmental impacts of a product system throughout its life cycle. It can be successfully applied to municipal solid waste management systems to identify the overall environmental burdens and to assess the potential environmental impacts. This paper deals with the LCA of the two waste management options for final disposal of municipal waste, landfilling (landfill without landfill gas collection or leachate collection and sanitary landfilling (landfill with landfill gas collection and recovery and leachate collection and treatments analyzed for town Sombor, Serbia. The research is conducted with the use of the Software Package IWM-2. The indicators which are used in the assessment are air and water emissions of toxic compounds. The results indicated that waste disposal practice has a significant effect on the emission of the toxic components and environmental burdens. Sanitary landfilling of municipal solid waste significantly reduces toxic emission and negative influence on the environment.

  7. Carbon cycle

    Energy Technology Data Exchange (ETDEWEB)

    Jaeger, J; Halbritter, G; Neumann-Hauf, G

    1982-05-01

    This report contains a review of literature on the subjects of the carbon cycle, the increase of the atmospheric CO/sub 2/ concentration and the possible impacts of an increased CO/sub 2/ concentration on the climate. In addition to this survey, the report discusses the questions that are still open and the resulting research needs. During the last twenty years a continual increase of the atmospheric carbon dioxide concentration by about 1-2 ppm per years has been observed. In 1958 the concentration was 315 ppm and this increased to 336 ppm in 1978. A rough estimate shows that the increase of the atmospheric carbon dioxide concentration is about half of the amount of carbon dioxide added to the atmosphere by the combustion of fossil fuels. Two possible sinks for the CO/sub 2/ released into the atmosphere are known: the ocean and the biota. The role of the biota is, however, unclear, since it can act both as a sink and as a source. Most models of the carbon cycle are one-dimensional and cannot be used for accurate predictions. Calculations with climate models have shown that an increased atmospheric CO/sub 2/ concentration leads to a warming of the earth's surface and lower atmosphere. Calculations show that a doubling of the atmospheric CO/sub 2/-concentration would lead to a net heating of the lower atmosphere and earth's surface by a global average of about 4 W m/sup -2/. Greater uncertainties arise in estimating the change in surface temperature resulting from this change in heating rate. It is estimated that the global average annual surface temperature would change between 1.5 and 4.5 K. There are, however, latitudinal and seasonal variations of the impact of increased CO/sub 2/ concentration. Other meteorological variables (e.g. precipitation, wind speed etc.) would also be changed. It appears that the impacts of the other products of fossil fuel combustion are unlikely to counteract the impacts of CO/sub 2/ on the climate.

  8. Fuel cycle centres

    International Nuclear Information System (INIS)

    Hagen, M.

    1977-01-01

    The concept of co-locating and integrating fuel cycle facilities at one site is discussed. This concept offers considerable advantages, especially in minimizing the amount of radioactive material to be transported on public roads. Safeguards and physical protection as relating to such an integrated system of facilities are analysed in detail, also industrial and commercial questions. An overall risk-benefit evaluation turns out to be in favour of fuel cycle centres. These centres seem to be specifically attractive with regard to the back end of the fuel cycle, including on-site disposal of radioactive wastes. The respective German approach is presented as an example. Special emphasis is given to the site selection procedures in this case. Time scale and cost for the implementation of this concept are important factors to be looked at. Since participation of governmental institutions in these centres seems to be indispensable their respective roles as compared to industry must be clearly defined. The idea of adjusting fuel cycle centres to regional rather than national use might be an attractive option, depending on the specific parameters in the region, though results of existing multinational ventures are inconclusive in this respect. Major difficulties might be expected e.g. because of different national safety regulations and standards as well as commercial conditions among partner countries. Public acceptance in the host country seems to be another stumbling block for the realization of this type of multinational facilities

  9. Your Menstrual Cycle

    Science.gov (United States)

    ... your menstrual cycle What happens during your menstrual cycle The menstrual cycle includes not just your period, but the rise ... that take place over the weeks in your cycle. Want to know what happens on each day ...

  10. As above, so below? How the interplay between overstory species and edaphic factors influences the magnitude and mechanisms of belowground carbon cycles.

    Science.gov (United States)

    Desie, Ellen; Vancampenhout, Karen; Buelens, Jeroen; Verstraeten, Gorik; Verheyen, Kris; Heyens, Kathleen; Muys, Bart

    2017-04-01

    The choice of overstory species in relation to soil properties is one of the most important management decisions in forestry, especially when deciduous or mixed stands are replaced by coniferous monocultures. When assessed in relation to climate change, conversion effects are mainly studied in terms of total carbon stocks. These are generally considered to evolve linearly, according to similar stabilization processes across ecosystems. Here we show that the belowground carbon cycle is subject to ecosystem-specific stable process domains. The process domains are separated by steep thresholds, or even tipping points, where a small increase in environmental forcing can cause a drastic change in the way the ecosystem processes carbon. These effects are demonstrated in detail for the old-growth forest complex of the Gaume in Belgium. This forest spans a lithological gradient and mixed-species stands occur next to stands recently converted to Norway spruce (Picea abies) monocultures, creating a setting of paired plots that allow to address the magnitude of management choices relative to intrinsic natural potential. Vegetation descriptions, litter samples and soil samples at different depths were compared for above- and belowground functional biodiversity, litter layer characteristics, soil properties, nutrient status, bioturbation, soil carbon stocks and soil carbon functional pools. Results show that in soils with limited remaining buffer capacity, overstory-induced acidification under spruce causes a shift to an acid aluminum buffered environment, with a collapse in variability of abiotic and biotic soil properties. This entails a shift in soil fauna and depth relations, with a clear decoupling of the litter layer from the topsoil and the subsoil in terms of biological communities, carbon input and stochastic constraints. Finally, this study indicates that although spruce conversion increases the total soil carbon stocks, this extra carbon is stored in more labile

  11. Measuring risky adolescent cycling behaviour.

    Science.gov (United States)

    Feenstra, Hans; Ruiter, Robert A C; Schepers, Jan; Peters, Gjalt-Jorn; Kok, Gerjo

    2011-09-01

    Adolescents are at a greater risk of being involved in traffic accidents than most other age groups, even before they start driving cars. This article aims to determine the factor structure of a self-report questionnaire measuring adolescent risky cycling behaviour, the ACBQ (Adolescent Cycling Behaviour Questionnaire). The questionnaire's structure was based on the widely used Driver Behaviour Questionnaire (DBQ). A sample of secondary school students (N = 1749; age range: 13-18 years) filled out the questionnaire. Factor analysis revealed a three-factor structure underlying the questionnaire, which was confirmed on two equally large portions of the entire sample. These three underlying factors were identified as errors, common violations and exceptional violations. The ACBQ is a useful instrument for measuring adolescents' risky cycling behaviour.

  12. Expression of leukaemia inhibitory factor at the conceptus-maternal interface during preimplantation development and in the endometrium during the oestrous cycle in the mare

    NARCIS (Netherlands)

    De Ruijter-Villani, M.; Deelen, C.; Stout, T. A E

    2016-01-01

    Leukaemia inhibitory factor (LIF) plays a critical role in blastocyst development and implantation in several species. The present study investigated mRNA and protein expression for LIF, as well as the low-affinity LIF receptor (LIFR) and interleukin-6 signal transducer (IL6ST), in equine

  13. Success factors in top career : Towards a life-cycle model on careers of women and men, inside and outside the hospitality

    NARCIS (Netherlands)

    Sok, J.; Blomme, R.J.; Tromp, D.M.; Muijen, van J.J.

    2011-01-01

    The purpose of this research project was to identify success factors in the careers of top women in the hospitality industry. We started out by interviewing five women who are currently working in a high management position in the hospitality industry, about their experiences on their way to the

  14. Characterisation and normalisation factors for life cycle impact assessment mined abiotic resources categories in South Africa - The manufacturing of catalytic converter exhaust systems as a case study

    CSIR Research Space (South Africa)

    Strauss, K

    2006-05-01

    Full Text Available of the most commonly produced minerals in South Africa is used as basis to determine characterisation factors for a non-renewable mineral resources category. The average production of these minerals from 1991 to 2000 is compared to economically Demonstrated...

  15. Comparative Study of the Life Cycle Dependent Post-Translation Modifications of Protein Synthesis Elongation Factor Tu Present in the Membrane Proteome of Streptomycetes and Mycobacteria

    Czech Academy of Sciences Publication Activity Database

    Holub, Martin; Bezoušková, Silvia; Petráčková, Denisa; Kalachová, Ladislava; Kofroňová, Olga; Benada, Oldřich; Weiser, Jaroslav

    2010-01-01

    Roč. 55, č. 3 (2010), s. 203-210 ISSN 0015-5632 R&D Projects: GA AV ČR IAA600200702; GA AV ČR IAA500200913 Institutional research plan: CEZ:AV0Z50200510 Keywords : ESCHERICHIA-COLI * COELICOLOR A3(2) * OUTER-MEMBRANE Subject RIV: EE - Microbiology, Virology Impact factor: 0.977, year: 2010

  16. High-throughput gene expression profiling indicates dysregulation of intestinal cell cycle mediators and growth factors during primary simian immunodeficiency virus infection

    Energy Technology Data Exchange (ETDEWEB)

    George, Michael D; Sankaran, Sumathi; Reay, Elizabeth; Gelli, Angie C; Dandekar, Satya

    2003-07-20

    During primary simian immunodeficiency virus (SIV) infection, CD4+ T cells are severely depleted in gut-associated lymphoid tissue (GALT), while CD8+ T-cell numbers dramatically increase. To gain an understanding of the molecular basis of this disruption in T-cell homeostasis, host gene expression was monitored in longitudinal jejunum tissue biopsies from SIV-infected rhesus macaques by DNA microarray analysis. Transcription of cyclin E1, CDC2, retinoblastoma, transforming growth factor (TGF), fibroblast growth factor (FGF), and interleukin-2 was repressed while cyclins B1 and D2 and transcription factor E2F were upregulated, indicating a complex dysregulation of growth and proliferation within the intestinal mucosa. Innate, cell-mediated, and humoral immune responses were markedly upregulated in animals that significantly reduced their viral loads and retained more intestinal CD4+ T cells. We conclude that the alterations in intestinal gene expression during primary SIV infection were characteristic of a broad-range immune response, and reflective of the efficacy of viral suppression.

  17. High-throughput gene expression profiling indicates dysregulation of intestinal cell cycle mediators and growth factors during primary simian immunodeficiency virus infection

    International Nuclear Information System (INIS)

    George, Michael D.; Sankaran, Sumathi; Reay, Elizabeth; Gelli, Angie C.; Dandekar, Satya

    2003-01-01

    During primary simian immunodeficiency virus (SIV) infection, CD4+ T cells are severely depleted in gut-associated lymphoid tissue (GALT), while CD8+ T-cell numbers dramatically increase. To gain an understanding of the molecular basis of this disruption in T-cell homeostasis, host gene expression was monitored in longitudinal jejunum tissue biopsies from SIV-infected rhesus macaques by DNA microarray analysis. Transcription of cyclin E1, CDC2, retinoblastoma, transforming growth factor (TGF), fibroblast growth factor (FGF), and interleukin-2 was repressed while cyclins B1 and D2 and transcription factor E2F were upregulated, indicating a complex dysregulation of growth and proliferation within the intestinal mucosa. Innate, cell-mediated, and humoral immune responses were markedly upregulated in animals that significantly reduced their viral loads and retained more intestinal CD4+ T cells. We conclude that the alterations in intestinal gene expression during primary SIV infection were characteristic of a broad-range immune response, and reflective of the efficacy of viral suppression

  18. Transcription Factors Synergistically Activated at the Crossing of the Restriction Point between G1 and S Cell Cycle Phases. Pathologic Gate Opening during Multi-Hit Malignant Transformation

    Directory of Open Access Journals (Sweden)

    Nicoletta Castagnino

    2016-12-01

    Full Text Available Transcription factors (TFs represent key regulators of gene-expression patterns controlling cell behavior. TFs are active at nuclear – chromatin levels. TFs do not act in isolation; small sets of TFs cooperate toward the transcription of sets of mRNAs and consequently the translation of new proteins (the molecular phenotypes of a cell. Most TFs are activated through a cascade of biochemical reactions mediated by receptors expressed on the target cell surface. Nuclear Receptors (NRs are transcription factors activated instead by small hydrophobic molecules capable of crossing the plasma membrane. The convergence of different pathways on TFs and their posttranslational modifications ensure that the external stimuli generate appropriate and integrated responses. The reconstruction of the molecular anatomy of these pathways through Molecular Interactions Maps (MIMs can depict these intricate interactions. A mathematical modeling approach simulates/mimics their mechanism of action in normal and pathological conditions. We can simulate the effect of virtual hits in neoplastic transformation as mutations/alterations in these pathways. We can also simulate the effect of targeted inhibitors on these deregulated pathways. This strategy can help to guide an appropriate combination of targeted drugs in the treatment of a cancer patient, a major innovative perspective of incoming years.

  19. Limit cycles in quantum systems

    Energy Technology Data Exchange (ETDEWEB)

    Niemann, Patrick

    2015-04-27

    In this thesis we investigate Limit Cycles in Quantum Systems. Limit cycles are a renormalization group (RG) topology. When degrees of freedom are integrated out, the coupling constants flow periodically in a closed curve. The presence of limit cycles is restricted by the necessary condition of discrete scale invariance. A signature of discrete scale invariance and limit cycles is log-periodic behavior. The first part of this thesis is concerned with the study of limit cycles with the similarity renormalization group (SRG). Limit cycles are mainly investigated within conventional renormalization group frameworks, where degrees of freedom, which are larger than a given cutoff, are integrated out. In contrast, in the SRG potentials are unitarily transformed and thereby obtain a band-diagonal structure. The width of the band structure can be regarded as an effective cutoff. We investigate the appearance of limit cycles in the SRG evolution. Our aim is to extract signatures as well as the scaling factor of the limit cycle. We consider the 1/R{sup 2}-potential in a two-body system and a three-body system with large scattering lengths. Both systems display a limit cycle. Besides the frequently used kinetic energy generator we apply the exponential and the inverse generator. In the second part of this thesis, Limit Cycles at Finite Density, we examine the pole structure of the scattering amplitude for distinguishable fermions at zero temperature in the medium. Unequal masses and a filled Fermi sphere for each fermion species are considered. We focus on negative scattering lengths and the unitary limit. The properties of the three-body spectrum in the medium and implications for the phase structure of ultracold Fermi gases are discussed.

  20. Cell-cycle-dependent three-dimensional redistribution of nuclear proteins, P 120, pKi-67, and SC 35 splicing factor, in the presence of the topoisomerase I inhibitor camptothecin.

    Science.gov (United States)

    Elias, Emmanuel; Lalun, Nathalie; Lorenzato, Marianne; Blache, Laurent; Chelidze, Pavel; O'Donohue, Marie-Françoise; Ploton, Dominique; Bobichon, Hélène

    2003-11-15

    Topoisomerase I (Topo I) is mostly known for its role in DNA relaxation, which is required for duplication and transcription. Topo I acts as a protein kinase mainly directed to the mRNA splicing factor SC35. Camptothecin is one of the specific Topo I inhibitors and is effective on the two functions of the enzyme. In this study we demonstrated that treatment of KB cells with camptothecin for only 30 min induced the 3D reorganization and redistribution of three proteins involved in the nucleus machinery, P 120, pKi-67, and SC 35, and this occurred in a cell cycle-dependent manner. Our data were obtained from confocal microscopic studies after immunolabeling, 3D reconstruction, and measurement of the nuclear components volumes. In the presence of camptothecin, P 120, which occupied the nucleolar volume, lost its reticulation and pKi-67 was redistributed within the nucleoplasm and even into the cytoplasm. Finally, for SC 35 the fusion of its dots into bigger volumes was observed specifically during the G1 phase. Variations of volumes were also observed for the nucleolus and for the nucleus. These results pointed out that, depending on the cell cycle phase, Topo I functions were selective toward the three different proteins.

  1. Bipolar mood cycles and lunar tidal cycles.

    Science.gov (United States)

    Wehr, T A

    2018-04-01

    In 17 patients with rapid cycling bipolar disorder, time-series analyses detected synchronies between mood cycles and three lunar cycles that modulate the amplitude of the moon's semi-diurnal gravimetric tides: the 14.8-day spring-neap cycle, the 13.7-day declination cycle and the 206-day cycle of perigee-syzygies ('supermoons'). The analyses also revealed shifts among 1:2, 1:3, 2:3 and other modes of coupling of mood cycles to the two bi-weekly lunar cycles. These shifts appear to be responses to the conflicting demands of the mood cycles' being entrained simultaneously to two different bi-weekly lunar cycles with slightly different periods. Measurements of circadian rhythms in body temperature suggest a biological mechanism through which transits of one of the moon's semi-diurnal gravimetric tides might have driven the patients' bipolar cycles, by periodically entraining the circadian pacemaker to its 24.84-h rhythm and altering the pacemaker's phase-relationship to sleep in a manner that is known to cause switches from depression to mania.

  2. Polity age and political budget cycles

    DEFF Research Database (Denmark)

    Aaskoven, Lasse

    2018-01-01

    Incumbent incentive for competence-signaling and lack of voter information are generally thought to be factors that increase the prevalence of political budget cycles. These mechanisms should be more prevalent in new political units. Since the creation of new political units is rarely exogenous......-experimental to study whether political budget cycles are larger in new political units. Contrary to theoretical predictions, political budget cycles seem to be of a smaller scale in the new municipalities, but only regarding budget cycles in budgetary overruns. The findings are of wider interest for discussions about...... the mechanisms behind context-conditional political budget cycles....

  3. Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

    International Nuclear Information System (INIS)

    Higgins, Larry G.; Kelleher, Michael O.; Eggleston, Ian M.; Itoh, Ken; Yamamoto, Masayuki; Hayes, John D.

    2009-01-01

    Sulforaphane can stimulate cellular adaptation to redox stressors through transcription factor Nrf2. Using mouse embryonic fibroblasts (MEFs) as a model, we show herein that the normal homeostatic level of glutathione in Nrf2 -/- MEFs was only 20% of that in their wild-type counterparts. Furthermore, the rate of glutathione synthesis following its acute depletion upon treatment with 3 μmol/l sulforaphane was very substantially lower in Nrf2 -/- MEFs than in wild-type cells, and the rebound leading to a ∼ 1.9-fold increase in glutathione that occurred 12-24 h after Nrf2 +/+ MEFs were treated with sulforaphane was not observed in Nrf2 -/- fibroblasts. Wild-type MEFs that had been pre-treated for 24 h with 3 μmol/l sulforaphane exhibited between 1.4- and 3.2-fold resistance against thiol-reactive electrophiles, including isothiocyanates, α,β-unsaturated carbonyl compounds (e.g. acrolein), aryl halides and alkene epoxides. Pre-treatment of Nrf2 +/+ MEFs with sulforaphane also protected against hydroperoxides (e.g. cumene hydroperoxide, CuOOH), free radical-generating compounds (e.g. menadione), and genotoxic electrophiles (e.g. chlorambucil). By contrast, Nrf2 -/- MEFs were typically ∼ 50% less tolerant of these agents than wild-type fibroblasts, and sulforaphane pre-treatment did not protect the mutant cells against xenobiotics. To test whether Nrf2-mediated up-regulation of glutathione represents the major cytoprotective mechanism stimulated by sulforaphane, 5 μmol/l buthionine sulfoximine (BSO) was used to inhibit glutathione synthesis. In Nrf2 +/+ MEFs pre-treated with sulforaphane, BSO diminished intrinsic resistance and abolished inducible resistance to acrolein, CuOOH and chlorambucil, but not menadione. Thus Nrf2-dependent up-regulation of GSH is the principal mechanism by which sulforaphane pre-treatment induced resistance to acrolein, CuOOH and chlorambucil, but not menadione.

  4. Menopause: A Life Cycle Transition.

    Science.gov (United States)

    Evarts, Barbara Kess; Baldwin, Cynthia

    1998-01-01

    Family therapists need to address the issue of menopause proactively to be of benefit to couples and families during this transitional period in the family life cycle. Physical, psychological, and psychosocial factors affecting the menopausal woman and her family, and ways to address these issues in counseling are discussed. (Author/EMK)

  5. A idade como fator prognóstico in vitro The age as a predictive factor in in vitro fertilization cycles

    Directory of Open Access Journals (Sweden)

    Luiz Mauro Oliveira Gomes

    2009-05-01

    the embryonary quality is not different among women from different age groups, the number of collected oocytes, the number of transferred embryos and the pregnancy rate indicate that the women's age is an important predictive factor of success for the techniques of assisted reproduction and should be taken into consideration when this kind of treatment is proposed to women over 40.

  6. Fuel cycle math - part one

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    This article is Part One of a two-part article that reviews some of the numbers associated with the nuclear fuel cycle. The contents of Part One include: composition of the element uranium, considering atomic mass and weight-percent of the isotopes; uranium in the ground, including ore grades; mining, with dilution factors and recovery rates; ore sorting, including concentration factors; and uranium recovery. No financial information is presented in either Part One or Part Two

  7. Essays on economic cycles

    NARCIS (Netherlands)

    Groot, de E.A. (Bert)

    2006-01-01

    Schumpeter’s line of thought of multiple economic cycles is further investigated. The existence of multiple cycles in economic variables is demonstrated. In basic innovations five different cycles are found. Multiple cycle structures are shown in various macro-economic variables from the United

  8. Fuel cycles using adulterated plutonium

    International Nuclear Information System (INIS)

    Brooksbank, R.E.; Bigelow, J.E.; Campbell, D.O.; Kitts, F.G.; Lindauer, R.B.

    1978-01-01

    Adjustments in the U-Pu fuel cycle necessitated by decisions made to improve the nonproliferation objectives of the US are examined. The uranium-based fuel cycle, using bred plutonium to provide the fissile enrichment, is the fuel system with the highest degree of commercial development at the present time. However, because purified plutonium can be used in weapons, this fuel cycle is potentially vulnerable to diversion of that plutonium. It does appear that there are technologically sound ways in which the plutonium might be adulterated by admixture with 238 U and/or radioisotopes, and maintained in that state throughout the fuel cycle, so that the likelihood of a successful diversion is small. Adulteration of the plutonium in this manner would have relatively little effect on the operations of existing or planned reactors. Studies now in progress should show within a year or two whether the less expensive coprocessing scheme would provide adequate protection (coupled perhaps with elaborate conventional safeguards procedures) or if the more expensive spiked fuel cycle is needed as in the proposed civex pocess. If the latter is the case, it will be further necessary to determine the optimum spiking level, which could vary as much as a factor of a billion. A very basic question hangs on these determinations: What is to be the nature of the recycle fuel fabrication facilities. If the hot, fully remote fuel fabrication is required, then a great deal of further development work will be required to make the full cycle fully commercial

  9. Mole sieve cycle optimization

    Energy Technology Data Exchange (ETDEWEB)

    Croteau, P. [Petro-Canada Oil and Gas, Inc., Calgary, AB (Canada)

    2004-07-01

    Maturing gas basins and declining reservoirs have prompted the search for energy and cost reduction initiatives to maintain operation sustainability. This paper discusses the development of an algorithm to improve the efficiency of the Brazeau mole sieve dehydration system. Details of the operating unit and an outline of the system were provided, as well as an operator interface. The main objectives of the research were to reduce the number of corresponding regeneration cycles; reduce annual energy requirements; and extend the life of the dessicant. Reductions were anticipated at 35 per cent, leading towards fuel savings of $45,000 a year, and carbon dioxide reductions of 670 tonnes a year. However, significant barriers were also noted, including operations, maintenance and equipment replacement issues. Equations of state were used to estimate vapor pressure or water content in gases. Approximate water content was measured with gas flow rate. The resulting algorithm was implemented using a basic best fit curve generated for one variable with a correction factor applied as a second variable. Data books were provided to present water content of hydrocarbon gas, with implementation procedures. Benefits of the new system included longer service life and reduced chemical and outside service costs, and reduced lost production during sieve changes. Additional benefits included enhanced distributed computing system (DCS) interfaces within plant operations; extension of the adsorption cycle via the functionality of the algorithm; and the fact that during a plant upset, the algorithm froze cycle sequencing and eliminated the possibility of switching the beds and repeating regeneration. The improved system resulted in savings of $87,000. tabs, figs.

  10. Nuclear power fuel cycle

    International Nuclear Information System (INIS)

    Havelka, S.; Jakesova, L.

    1982-01-01

    Economic problems are discussed of the fuel cycle (cost of the individual parts of the fuel cycle and the share of the fuel cycle in the price of 1 kWh), the technological problems of the fuel cycle (uranium ore mining and processing, uranium isotope enrichment, the manufacture of fuel elements, the building of long-term storage sites for spent fuel, spent fuel reprocessing, liquid and gaseous waste processing), and the ecologic aspects of the fuel cycle. (H.S.)

  11. Overview of the nuclear fuel cycle

    International Nuclear Information System (INIS)

    Knief, R.A.

    1978-01-01

    The nuclear fuel cycle is substantially more complicated than the energy production cycles of conventional fuels because of the very low abundance of uranium 235, the presence of radioactivity, the potential for producing fissile nuclides from irradiation, and the risk that fissile materials will be used for nuclear weapons. These factors add enrichment, recycling, spent fuel storage, and safeguards to the cycle, besides making the conventional steps of exploration, mining, processing, use, waste disposal, and transportation more difficult

  12. The centriole duplication cycle

    Science.gov (United States)

    Fırat-Karalar, Elif Nur; Stearns, Tim

    2014-01-01

    Centrosomes are the main microtubule-organizing centre of animal cells and are important for many critical cellular and developmental processes from cell polarization to cell division. At the core of the centrosome are centrioles, which recruit pericentriolar material to form the centrosome and act as basal bodies to nucleate formation of cilia and flagella. Defects in centriole structure, function and number are associated with a variety of human diseases, including cancer, brain diseases and ciliopathies. In this review, we discuss recent advances in our understanding of how new centrioles are assembled and how centriole number is controlled. We propose a general model for centriole duplication control in which cooperative binding of duplication factors defines a centriole ‘origin of duplication’ that initiates duplication, and passage through mitosis effects changes that license the centriole for a new round of duplication in the next cell cycle. We also focus on variations on the general theme in which many centrioles are created in a single cell cycle, including the specialized structures associated with these variations, the deuterosome in animal cells and the blepharoplast in lower plant cells. PMID:25047614

  13. Economic comparison of fusion fuel cycles

    International Nuclear Information System (INIS)

    Brereton, S.J.; Kazimi, M.S.

    1987-01-01

    The economics of the DT, DD, and DHe fusion fuel cycles are evaluated by comparison on a consistent basis. The designs for the comparison employ HT-9 structure and helium coolant; liquid lithium is used as the tritium breeding material for the DT fuel cycle. The reactors are pulsed, superconducting tokamaks, producing 1200 MW of electric power. The DT and DD designs scan a range of values of plasma beta, assuming first stability scaling laws. The results indicate that on a purely economic basis, the DT fuel cycle is superior to both of the advanced fuel cycles. Geometric factors, materials limitations, and plasma beta were seen to have an impact on the Cost of Electricity (COE). The economics for the DD fuel cycle are more strongly affected by these parameters than is the DT fuel cycle. Fuel costs are a major factor in determining the COE for the DHe fuel cycle. Based on costs directly attributable to the fuel cycle, the DT fuel cycle appears most attractive. Technological advances, improved understanding of physics, or strides in advanced energy conversion schemes may result in altering the economic ranking of the fuel cycles indicated here. 7 refs., 6 figs., 2 tabs

  14. The planning cycle.

    Science.gov (United States)

    Johnson, William

    2005-01-01

    Information technology planning can be described as a continuous cyclical process composed of three phases whose primary purpose is optimum allocation of scarce resources. In the assessment phase, planners assess user needs, environmental factors, business objectives, and IT infrastructure needs to develop IT projects that address needs in each of these areas. A major goal of this phase is to develop a broad IT inventory. The prioritization phase seeks to ensure optimum allocation of scarce resources by prioritizing ITprojects based on: Costs--total life cycle costs. Benefits--both quantitative and non-quantitative, including support for the organization's strategic business objectives. Risks--subjective assessments of technological and non-technological risks. Implementation requirements--time and personnel requirements to implement the system. The scheduling phase incorporates sequencing considerations, personnel availability, and budgetary constraints to produce an IT plan in which project priorities are adjusted to meet organizational realities.

  15. Proliferation in cycle

    Energy Technology Data Exchange (ETDEWEB)

    Piao Yunsong [College of Physical Sciences, Graduate School of Chinese Academy of Sciences, Beijing 100049 (China)], E-mail: yspiao@gucas.ac.cn

    2009-06-15

    In the contracting phase with w{approx_equal}0, the scale invariant spectrum of curvature perturbation is given by the increasing mode of metric perturbation. In this Letter, it is found that if the contracting phase with w{approx_equal}0 is included in each cycle of a cycle universe, since the metric perturbation is amplified on super horizon scale cycle by cycle, after each cycle the universe will be inevitably separated into many parts independent of one another, each of which corresponds to a new universe and evolves up to next cycle, and then is separated again. In this sense, a cyclic multiverse scenario is actually presented, in which the universe proliferates cycle by cycle. We estimate the number of new universes proliferated in each cycle, and discuss the implications of this result.

  16. Proliferation in cycle

    International Nuclear Information System (INIS)

    Piao Yunsong

    2009-01-01

    In the contracting phase with w≅0, the scale invariant spectrum of curvature perturbation is given by the increasing mode of metric perturbation. In this Letter, it is found that if the contracting phase with w≅0 is included in each cycle of a cycle universe, since the metric perturbation is amplified on super horizon scale cycle by cycle, after each cycle the universe will be inevitably separated into many parts independent of one another, each of which corresponds to a new universe and evolves up to next cycle, and then is separated again. In this sense, a cyclic multiverse scenario is actually presented, in which the universe proliferates cycle by cycle. We estimate the number of new universes proliferated in each cycle, and discuss the implications of this result.

  17. Recent developments in the nuclear fuel cycle

    International Nuclear Information System (INIS)

    Wunderer, A.

    1984-01-01

    There is a description of the present situation in each individual area of the nuclear fuel cycle. Further topics are: risk and safety factors and emissions from the fuel cycle, availability and disruptions, waste disposal and the storage of radioactive waste. (UA) [de

  18. Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter.

    Directory of Open Access Journals (Sweden)

    Richard J Kraus

    2017-06-01

    Full Text Available When confronted with poor oxygenation, cells adapt by activating survival signaling pathways, including the oxygen-sensitive transcriptional regulators called hypoxia-inducible factor alphas (HIF-αs. We report here that HIF-1α also regulates the life cycle of Epstein-Barr virus (EBV. Incubation of EBV-positive gastric carcinoma AGS-Akata and SNU-719 and Burkitt lymphoma Sal and KemIII cell lines with a prolyl hydroxylase inhibitor, L-mimosine or deferoxamine, or the NEDDylation inhibitor MLN4924 promoted rapid and sustained accumulation of both HIF-1α and lytic EBV antigens. ShRNA knockdown of HIF-1α significantly reduced deferoxamine-mediated lytic reactivation. HIF-1α directly bound the promoter of the EBV primary latent-lytic switch BZLF1 gene, Zp, activating transcription via a consensus hypoxia-response element (HRE located at nt -83 through -76 relative to the transcription initiation site. HIF-1α did not activate transcription from the other EBV immediate-early gene, BRLF1. Importantly, expression of HIF-1α induced EBV lytic-gene expression in cells harboring wild-type EBV, but not in cells infected with variants containing base-pair substitution mutations within this HRE. Human oral keratinocyte (NOK and gingival epithelial (hGET cells induced to differentiate by incubation with either methyl cellulose or growth in organotypic culture accumulated both HIF-1α and Blimp-1α, another cellular factor implicated in lytic reactivation. HIF-1α activity also accumulated along with Blimp-1α during B-cell differentiation into plasma cells. Furthermore, most BZLF1-expressing cells observed in lymphomas induced by EBV in NSG mice with a humanized immune system were located distal to blood vessels in hypoxic regions of the tumors. Thus, we conclude that HIF-1α plays central roles in both EBV's natural life cycle and EBV-associated tumorigenesis. We propose that drugs that induce HIF-1α protein accumulation are good candidates for

  19. Cycling in Sydney, Australia

    Directory of Open Access Journals (Sweden)

    Alexis Zander

    2013-01-01

    Full Text Available Introduction. Cycling can be an enjoyable way to meet physical activity recommendations and is suitable for older people; however cycling participation by older Australians is low. This qualitative study explored motivators, enablers, and barriers to cycling among older people through an age-targeted cycling promotion program. Methods. Seventeen adults who aged 50–75 years participated in a 12-week cycling promotion program which included a cycling skills course, mentor, and resource pack. Semistructured interviews at the beginning and end of the program explored motivators, enablers, and barriers to cycling. Results. Fitness and recreation were the primary motivators for cycling. The biggest barrier was fear of cars and traffic, and the cycling skills course was the most important enabler for improving participants’ confidence. Reported outcomes from cycling included improved quality of life (better mental health, social benefit, and empowerment and improved physical health. Conclusions. A simple cycling program increased cycling participation among older people. This work confirms the importance of improving confidence in this age group through a skills course, mentors, and maps and highlights additional strategies for promoting cycling, such as ongoing improvement to infrastructure and advertising.

  20. Biogeochemical cycling in the Taiwan Strait

    Digital Repository Service at National Institute of Oceanography (India)

    Naik, H.; Chen, C-T.A.

    Based on repeat observations made during 2001-2003 along two transects in the Taiwan Strait this study aims at understanding factors controlling primary productivity with an emphasis on biogeochemical cycling of nitrogen, the major bio...

  1. Life cycle assessment (LCA)

    DEFF Research Database (Denmark)

    Thrane, Mikkel; Schmidt, Jannick Andresen

    2004-01-01

    The chapter introduces Life Cycle Assessment (LCA) and its application according to the ISO 1404043 standards.......The chapter introduces Life Cycle Assessment (LCA) and its application according to the ISO 1404043 standards....

  2. Thorium fuel cycle management

    International Nuclear Information System (INIS)

    Zajac, R.; Darilek, P.; Breza, J.; Necas, V.

    2010-01-01

    In this presentation author deals with the thorium fuel cycle management. Description of the thorium fuels and thorium fuel cycle benefits and challenges as well as thorium fuel calculations performed by the computer code HELIOS are presented.

  3. Emission factors and chemical characterisation of fine particulate emissions from modern and old residential biomass heating systems determined for typical load cycles; Emissionsfaktoren und chemische Charakterisierung von Feinstaubemissionen moderner und alter Biomasse-Kleinfeuerungen ueber typische Tageslastverlaeufe

    Energy Technology Data Exchange (ETDEWEB)

    Kelz, Joachim [BIOENERGY 2020+ GmbH, Graz (Austria); Brunner, Thomas; Obernberger, Ingwald [BIOENERGY 2020+ GmbH, Graz (Austria); Technische Universitaet Graz, Institut fuer Prozess- und Partikeltechnik, Graz (Austria); BIOS BIOENERGIESYSTEME GmbH, Graz (Austria)

    2012-12-15

    It is already well known that there are significant differences regarding the emissions, especially particulate matter (PM) emissions, of old and modern as well as automatically and not automatically controlled biomass based residential heating systems. This concerns their magnitude as well as their chemical composition. In order to investigate emission factors for particulate emissions and the chemical compositions of the PM emissions over typical whole day operation cycles, a project on the determination and characterisation of PM emissions from the most relevant small-scale biomass combustion systems was performed at the BIOENERGY 2020+ GmbH, Graz, Austria, in cooperation with the Institute for Process and Particle Engineering, Graz University of Technology. The project was based on test stand measurements, during which relevant operation parameters (gaseous emissions, boiler load, flue gas temperature, combustion chamber temperature etc.) as well as PM emissions have been measured and PM samples have been taken and forwarded to chemical analyses. Firstly, typical whole day operation cycles for residential biomass combustion systems were specified for the test runs. Thereby automatically fed and automatically controlled boilers, manually fed and automatically controlled boilers as well as manually fed stoves were distinguished. The results show a clear correlation between the gaseous emissions (CO and OGC) and the PM{sub 1} emissions. It is indicated that modern biomass combustion systems emit significantly less gaseous and PM emissions than older technologies (up to a factor of 100). Moreover, automatically fed systems emit much less gaseous and PM emissions than manually fed batch-combustion systems. PM emissions from modern and automatically controlled systems mainly consist of alkaline metal salts, while organic aerosols and soot dominate the composition of aerosols from old and not automatically controlled systems. As an important result comprehensive data

  4. Chords in longest cycles

    DEFF Research Database (Denmark)

    Thomassen, Carsten

    2017-01-01

    If a graph G is 3-connected and has minimum degree at least 4, then some longest cycle in G has a chord. If G is 2-connected and cubic, then every longest cycle in G has a chord.......If a graph G is 3-connected and has minimum degree at least 4, then some longest cycle in G has a chord. If G is 2-connected and cubic, then every longest cycle in G has a chord....

  5. Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors

    Energy Technology Data Exchange (ETDEWEB)

    Glahn, Felix; Wiese, Jan; Foth, Heidi [Martin-Luther-University, Halle-Wittenberg, Institute of Environmental Toxicology, Halle/Saale (Germany); Schmidt-Heck, Wolfgang; Guthke, Reinhard [Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena (Germany); Zellmer, Sebastian; Gebhardt, Rolf [University of Leipzig, Institute of Biochemistry, Medical Faculty, Leipzig (Germany); Golka, Klaus; Degen, Gisela H.; Hermes, Matthias; Schormann, Wiebke; Brulport, Marc; Bauer, Alexander; Bedawy, Essam [IfADo, Leibniz Research Centre for Working Environment and Human Factors, Dortmund (Germany); Hergenroeder, Roland [ISAS, Institute for Analytical Sciences, Dortmund (Germany); Lehmann, Thomas [Translational Centre for Regenerative Medicine, Leipzig (Germany); Hengstler, Jan G. [IfADo, Leibniz Research Centre for Working Environment and Human Factors, Dortmund (Germany)

    2008-08-15

    Workers occupationally exposed to cadmium, cobalt and lead have been reported to have increased levels of DNA damage. To analyze whether in vivo relevant concentrations of heavy metals cause systematic alterations in RNA expression patterns, we performed a gene array study using primary normal human bronchial epithelial cells. Cells were incubated with 15{mu}g/l Cd(II), 25{mu}g/l Co(II) and 550{mu}g/l Pb(II) either with individual substances or in combination. Differentially expressed genes were filtered out and used to identify enriched GO categories as well as KEGG pathways and to identify transcription factors whose binding sites are enriched in a given set of promoters. Interestingly, combined exposure to Cd(II), Co(II) and Pb(II) caused a coordinated response of at least seven stress response-related transcription factors, namely Oct-1, HIC1, TGIF, CREB, ATF4, SRF and YY1. A stress response was further corroborated by up regulation of genes involved in glutathione metabolism. A second major response to heavy metal exposure was deregulation of the cell cycle as evidenced by down regulation of the transcription factors ELK-1 and the Ets transcription factor GABP, as well as deregulation of genes involved in purine and pyrimidine metabolism. A third and surprising response was up regulation of genes involved in steroid metabolism, whereby promoter analysis identified up regulation of SRY that is known to play a role in sex determination. A forth response was up regulation of xenobiotic metabolising enzymes, particularly of dihydrodiol dehydrogenases 1 and 2 (AKR1C1, AKR1C2). Incubations with individual heavy metals showed that the response of AKR1C1 and AKR1C2 was predominantly caused by lead. In conclusion, we have shown that in vivo relevant concentrations of Cd(II), Co(II) and Pb(II) cause a complex and coordinated response in normal human bronchial epithelial cells. This study gives an overview of the most responsive genes. (orig.)

  6. Denatured fuel cycles

    International Nuclear Information System (INIS)

    Till, C.E.

    1979-01-01

    This paper traces the history of the denatured fuel concept and discusses the characteristics of fuel cycles based on the concept. The proliferation resistance of denatured fuel cycles, the reactor types they involve, and the limitations they place on energy generation potential are discussed. The paper concludes with some remarks on the outlook for such cycles

  7. Life Cycle Management

    DEFF Research Database (Denmark)

    Bey, Niki

    2018-01-01

    This chapter gives an overview of Life Cycle Management (LCM)—a discipline that deals with the managerial tasks related to practicing sustainable development in an organisation . Just as Life Cycle Assessment, LCM advocates the life cycle perspective , and it applies this perspective in decision...

  8. Termination of cycle rewriting

    NARCIS (Netherlands)

    Zantema, H.; König, B.; Bruggink, H.J.S.; Dowek, G.

    2014-01-01

    String rewriting can not only be applied on strings, but also on cycles and even on general graphs. In this paper we investigate termination of string rewriting applied on cycles, shortly denoted as cycle rewriting, which is a strictly stronger requirement than termination on strings. Most

  9. The uranium cycle

    International Nuclear Information System (INIS)

    Ferguson, J.

    1988-01-01

    In identifying uranium provinces, and, more importantly, mineralized zones within these provinces, it is of paramount importance to attempt to trace the geochemical behaviour of an element through all stages of Earth's evolution. Aspects that need to be addressed in this regard include solar abundance levels and fractionation processes during accretion, changing patterns of crustal evolution, effects of an evolving atmosphere, and the weathering cycle. Abundance patterns and partition coefficients of some of the siderophile elements in mantle rocks lend support to a multistage accretionary process. Lack of a terrestrial record in the first 500 Ma necessitates that lunar models be invoked, which suggests that early fractionation of a mafic/ultramafic magma resulted in an anorthositic crust. Fractionation of the mantle and transfer of materials to the upper levels must be central to any model invoked for development of the crust. Given high heat flow conditions in the early Archaean it would seem inescapable that the process of sea floor spreading and plate tectonics was an ongoing process. If the plate tectonic model is taken back to 3500 Ma, and assuming current speading rates, then about half of the mantle has passed through the irreversible differentiation cycle. Arguments in support of recycled material must be balanced against mantle metasomatism effects. With the associated advent of partial melting of the mantle material a partitioning of minor and trace elements into the melt fraction would take place. The early primitive mafic and ultramafic komatiites exemplify this feature by concentrating U and Th by a factor of 5 compared to chondritic abundances. It is of tantamount importance to understand the generation of the magmas in order to predict which are the 'fertile' bodies in terms of radioelement concentrations. In that the granitoid magmas image their source compositions, the association of high radioelements will primarily be source-dependent. Uranium

  10. Marine nitrogen cycle

    Digital Repository Service at National Institute of Oceanography (India)

    Naqvi, S.W.A.

    ) such as the Marine nitrogen cycle The marine nitrogen cycle. ‘X’ and ‘Y’ are intra-cellular intermediates that do not accumulate in water column. (Source: Codispoti et al., 2001) Page 1 of 3Marine nitrogen cycle - Encyclopedia of Earth 11/20/2006http://www... and nitrous oxide budgets: Moving targets as we enter the anthropocene?, Sci. Mar., 65, 85-105, 2001. Page 2 of 3Marine nitrogen cycle - Encyclopedia of Earth 11/20/2006http://www.eoearth.org/article/Marine_nitrogen_cycle square6 Gruber, N.: The dynamics...

  11. Life-Cycle Cost-Benefit Analysis

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    2010-01-01

    The future use of Life-Cycle Cost-Benefit (LCCB) analysis is discussed in this paper. A more complete analysis including not only the traditional factors and user costs, but also factors which are difficult to include in the analysis is needed in the future.......The future use of Life-Cycle Cost-Benefit (LCCB) analysis is discussed in this paper. A more complete analysis including not only the traditional factors and user costs, but also factors which are difficult to include in the analysis is needed in the future....

  12. Technology cycles and technology revolutions

    Energy Technology Data Exchange (ETDEWEB)

    Paganetto, Luigi; Scandizzo, Pasquale Lucio

    2010-09-15

    Technological cycles have been characterized as the basis of long and continuous periods economic growth through sustained changes in total factor productivity. While this hypothesis is in part consistent with several theories of growth, the sheer magnitude and length of the economic revolutions experienced by humankind seems to indicate surmise that more attention should be given to the origin of major technological and economic changes, with reference to one crucial question: role of production and use of energy in economic development.

  13. Regional Business Cycles in East Asia: Synchronization and its Determinants

    OpenAIRE

    Young-Joon Park

    2013-01-01

    This paper analyzes the dynamics and nature of regional business cycle synchronization for East Asian countries in the period of 2000:Q1-2011:Q4. Estimating a dynamic two-factor model extracts the common factor and the nation- specific factor from both the macroeconomic aggregates and plausible driving forces of regional business cycles. Evidence for regional business cycle synchronization is particularly strong for Korea, Malaysia and the Philippines, while Japan shows weak evidence of regio...

  14. The Krebs Uric Acid Cycle: A Forgotten Krebs Cycle.

    Science.gov (United States)

    Salway, Jack G

    2018-05-25

    Hans Kornberg wrote a paper entitled 'Krebs and his trinity of cycles' commenting that every school biology student knows of the Krebs cycle, but few know that Krebs discovered two other cycles. These are (i) the ornithine cycle (urea cycle), (ii) the citric acid cycle (tricarboxylic acid or TCA cycle), and (iii) the glyoxylate cycle that was described by Krebs and Kornberg. Ironically, Kornberg, codiscoverer of the 'glyoxylate cycle', overlooked a fourth Krebs cycle - (iv) the uric acid cycle. Copyright © 2018 Elsevier Ltd. All rights reserved.

  15. Cell cycle gene expression under clinorotation

    Science.gov (United States)

    Artemenko, Olga

    2016-07-01

    Cyclins and cyclin-dependent kinase (CDK) are main regulators of the cell cycle of eukaryotes. It's assumes a significant change of their level in cells under microgravity conditions and by other physical factors actions. The clinorotation use enables to determine the influence of gravity on simulated events in the cell during the cell cycle - exit from the state of quiet stage and promotion presynthetic phase (G1) and DNA synthesis phase (S) of the cell cycle. For the clinorotation effect study on cell proliferation activity is the necessary studies of molecular mechanisms of cell cycle regulation and development of plants under altered gravity condition. The activity of cyclin D, which is responsible for the events of the cell cycle in presynthetic phase can be controlled by the action of endogenous as well as exogenous factors, but clinorotation is one of the factors that influence on genes expression that regulate the cell cycle.These data can be used as a model for further research of cyclin - CDK complex for study of molecular mechanisms regulation of growth and proliferation. In this investigation we tried to summarize and analyze known literature and own data we obtained relatively the main regulators of the cell cycle in altered gravity condition.

  16. Driving and engine cycles

    CERN Document Server

    Giakoumis, Evangelos G

    2017-01-01

    This book presents in detail the most important driving and engine cycles used for the certification and testing of new vehicles and engines around the world. It covers chassis and engine-dynamometer cycles for passenger cars, light-duty vans, heavy-duty engines, non-road engines and motorcycles, offering detailed historical information and critical review. The book also provides detailed examples from SI and diesel engines and vehicles operating during various cycles, with a focus on how the engine behaves during transients and how this is reflected in emitted pollutants, CO2 and after-treatment systems operation. It describes the measurement methods for the testing of new vehicles and essential information on the procedure for creating a driving cycle. Lastly, it presents detailed technical specifications on the most important chassis-dynamometer cycles around the world, together with a direct comparison of those cycles.

  17. International Business Cycle

    OpenAIRE

    Marek Lubiński

    2007-01-01

    Prime stylized facts of international business cycle theory refer to positive correlation in the cyclical components of important macroeconomic variables across countries. However a number of indicators of business cycle synchronization do not point to clear trends. It can be ascribed to the fact that different forces influence level of business cycle correlation. When investigating into the forces behind the commonness in aggregate fluctuations economic research seems to have pointed in two ...

  18. Fast breeder fuel cycle

    International Nuclear Information System (INIS)

    1978-09-01

    Basic elements of the ex-reactor part of the fuel cycle (reprocessing, fabrication, waste handling and transportation) are described. Possible technical and proliferation measures are evaluated, including current methods of accountability, surveillance and protection. The reference oxide based cycle and advanced cycles based on carbide and metallic fuels are considered utilizing conventional processes; advanced nonaqueous reprocessing is also considered. This contribution provides a comprehensive data base for evaluation of proliferation risks

  19. [Cycling in Zagreb].

    Science.gov (United States)

    Matos, Stipan; Krapac, Ladislav; Krapac, Josip

    2007-01-01

    Cycling in Zagreb, as means of urban transport inside and outside the city, has a bright past, hazy presence but a promising future. Every day, aggressive citizens who lack urban traffic culture mistreat many cyclists but also many pedestrians. Sedentary way of living, unhealthy eating habits and inadequate recreation would surely be reduced if Zagreb had a network of cycling tracks (190 cm) or lanes (80 cm). Main city roads were constructed at the beginning of the 20th century. Today, the lack of cycling tracks is particularly evident in terms of missing connections between northern and southern parts of the city. Transportation of bikes in public vehicles, parking of bikes as well as cycling along the foot of the mountains Medvednica and Zumberacko gorje is not adequately organized. Better organization is necessary not only because of the present young generation but also because of the young who will shortly become citizens of the EU, where cycling is enormously popular. Cycling tourism is not known in Zagreb, partly due to inadequate roads. The surroundings of Zagreb are more suitable for cycling tourism and attractive brochures and tourist guides offer information to tourists on bikes. Professional, acrobatic and sports cycling do not have a tradition in Zagreb and in Croatia. The same holds true for recreational cycling and indoor exercise cycling. The authors discuss the impact of popularization of cycling using print and electronic media. The role of district and local self-government in the construction and improvement of traffic roads in Zagreb is very important. It is also significant for the implementation of legal regulations that must be obeyed by all traffic participants in order to protect cyclists, the most vulnerable group of traffic participants besides passengers. Multidisciplinary action of all benevolent experts would surely increase safety and pleasure of cycling in the city and its surroundings. This would also help reduce daily stress and

  20. Measuring Business Cycle Time.

    OpenAIRE

    Stock, James H

    1987-01-01

    The business cycle analysis of Arthur F. Burns and Wesley C. Mitchell and the National Bureau of Economic Research presumed that aggregate economic variables evolve on a time scale defined by business cycle turning points rather than by months or quarters. Do macroeconomic variables appear to evolve on an economic rather than a calendar time scale? Evidence presented here suggests that they do. However, the estimated economic time scales are only weakly related to business cycle time scales, ...

  1. Thorium cycles and proliferation

    International Nuclear Information System (INIS)

    Lovins, A.B.

    1979-01-01

    This paper analyzes several prevalent misconceptions about nuclear fuel cycles that breed fissile uranium-233 from thorium. Its main conclusions are: U-233, despite the gamma radioactivity of associated isotopes, is a rather attractive material for making fission bombs, and is a credible material for subnational as well as national groups to use for this purpose; (2) pure thorium cycles, which in effect merely substitute U-233 for Pu, would take many decades and much U to establish, and offer no significant safeguards advantage over Pu, cycles; (3) denatured Th-U cycles, which dilute the U-233 with inert U-238 to a level not directly usable in bombs, are not an effective safeguard even against subnational bomb-making; (4) several other features of mixed Th-U cycles are rather unattractive from a safeguards point of view; (5) thus, Th cycles of any kind are not a technical fix for proliferation (national or subnational) and, though probably more safeguardable than Pu cycles, are less so than once-through U cycles that entail no reprocessing; (6) while thorium cycles have some potential technical advantages, including flexibility, they cannot provide major savings in nuclear fuel resources compared to simpler ways of saving neutrons and U; and (7) while advocates of nuclear power may find Th cycles worth exploring, such cycles do not differ fundamentally from U cycles in any of the respects--including safeguards and fuel resources--that are relevant to the broader nuclear debate, and should not be euphorically embraced as if they did

  2. Alternative fuel cycles

    International Nuclear Information System (INIS)

    Penn, W.J.

    1979-05-01

    Uranium resource utilization and economic considerations provide incentives to study alternative fuel cycles as future options to the PHWR natural uranium cycle. Preliminary studies to define the most favourable alternatives and their possible introduction dates are discussed. The important and uncertain components which influence option selection are reviewed, including nuclear capacity growth, uranium availability and demand, economic potential, and required technological developments. Finally, a summary of Ontario Hydro's program to further assess cycle selection and define development needs is given. (auth)

  3. Romanian nuclear fuel cycle development

    International Nuclear Information System (INIS)

    Rapeanu, S.N.; Comsa, Olivia

    1998-01-01

    Romanian decision to introduce nuclear power was based on the evaluation of electricity demand and supply as well as a domestic resources assessment. The option was the introduction of CANDU-PHWR through a license agreement with AECL Canada. The major factors in this choice have been the need of diversifying the energy resources, the improvement the national industry and the independence of foreign suppliers. Romanian Nuclear Power Program envisaged a large national participation in Cernavoda NPP completion, in the development of nuclear fuel cycle facilities and horizontal industry, in R and D and human resources. As consequence, important support was being given to development of industries involved in Nuclear Fuel Cycle and manufacturing of equipment and nuclear materials based on technology transfer, implementation of advanced design execution standards, QA procedures and current nuclear safety requirements at international level. Unit 1 of the first Romanian nuclear power plant, Cernavoda NPP with a final profile 5x700 Mw e, is now in operation and its production represents 10% of all national electricity production. There were also developed all stages of FRONT END of Nuclear Fuel Cycle as well as programs for spent fuel and waste management. Industrial facilities for uranian production, U 3 O 8 concentrate, UO 2 powder and CANDU fuel bundles, as well as heavy water plant, supply the required fuel and heavy water for Cernavoda NPP. The paper presents the Romanian activities in Nuclear Fuel Cycle and waste management fields. (authors)

  4. Reproductive cycles of deer.

    Science.gov (United States)

    Asher, G W

    2011-04-01

    The cervids are a complex assemblage of taxa showing extreme diversity in morphology, physiology, ecology and geographical distribution. Reproductive strategies adopted by various species are also diverse, and include a range from highly seasonal to completely aseasonal birth patterns. The recent growth in knowledge on cervid reproduction is strongly biased towards the larger-bodied, gregarious mixed grazer-browser species that have adapted well to human management and commercialisation. These species tend to represent 'K-selected' climax species characterised by very productive annual breeding success, singleton births and long breeding life (10+ years). Conversely, we know relatively little about the reproductive patterns of the 'r-selected' smaller-bodied, solitary (and often highly territorial), forest-dwelling browser species, often characterised by great fecundity (twinning) and shorter breeding life (<10 years). This group includes many of the endangered cervid taxa. This review extends earlier reviews to include more recent work on cervid reproductive cycles, particularly in relation to environmental factors influencing gestation length. Copyright © 2010 Elsevier B.V. All rights reserved.

  5. The closed fuel cycle

    International Nuclear Information System (INIS)

    Froment, Antoine; Gillet, Philippe

    2007-01-01

    Available in abstract form only. Full text of publication follows: The fast growth of the world's economy coupled with the need for optimizing use of natural resources, for energy security and for climate change mitigation make energy supply one of the 21. century most daring challenges. The high reliability and efficiency of nuclear energy, its competitiveness in an energy market undergoing a new oil shock are as many factors in favor of the 'renaissance' of this greenhouse gas free energy. Over 160,000 tHM of LWR1 and AGR2 Used Nuclear Fuel (UNF) have already been unloaded from the reactor cores corresponding to 7,000 tons discharged per year worldwide. By 2030, this amount could exceed 400,000 tHM and annual unloading 14,000 tHM/year. AREVA believes that closing the nuclear fuel cycle through the treatment and recycling of Used Nuclear Fuel sustains the worldwide nuclear power expansion. It is an economically sound and environmentally responsible choice, based on the preservation of natural resources through the recycling of used fuel. It furthermore provides a safe and secure management of wastes while significantly minimizing the burden left to future generations. (authors)

  6. Edgeworth cycles revisited

    International Nuclear Information System (INIS)

    Doyle, Joseph; Muehlegger, Erich; Samphantharak, Krislert

    2010-01-01

    Some gasoline markets exhibit remarkable price cycles, where price spikes are followed by a series of small price declines: a pattern consistent with a model of Edgeworth cycles described by Maskin and Tirole. We extend the model and empirically test its predictions with a new dataset of daily station-level prices in 115 US cities. Consistent with the theory, and often in contrast with previous empirical work, we find the least and most concentrated markets are much less likely to exhibit cycling behavior both within and across cities; areas with more independent convenience-store gas stations are also more likely to cycle. (author)

  7. Back-end of the nuclear fuel cycle

    International Nuclear Information System (INIS)

    Choi, J.S.

    2002-01-01

    Current strategies of the back-end nuclear fuel cycles are: (1) direct-disposal of spent fuel (Open Cycle), and (2) reprocessing of the spent fuel and recycling of the recovered nuclear materials (Closed Cycle). The selection of these strategies is country-specific, and factors affecting selection of strategy are identified and discussed in this paper. (author)

  8. CANDU fuel-cycle vision

    International Nuclear Information System (INIS)

    Boczar, P.G.

    1999-01-01

    The fuel-cycle path chosen by a particular country will depend on a range of local and global factors. The CANDU reactor provides the fuel-cycle flexibility to enable any country to optimize its fuel-cycle strategy to suit its own needs. AECL has developed the CANFLEX fuel bundle as the near-term carrier of advanced fuel cycles. A demonstration irradiation of 24 CANFLEX bundles in the Point Lepreau power station, and a full-scale critical heat flux (CHF) test in water are planned in 1998, before commercial implementation of CANFLEX fuelling. CANFLEX fuel provides a reduction in peak linear element ratings, and a significant enhancement in thermalhydraulic performance. Whereas natural uranium fuel provides many advantages, the use of slightly enriched uranium (SEU) in CANDU reactors offers even lower fuel-cycle costs and other benefits, such as uprating capability through flattening the channel power distribution across the core. Recycled uranium (RU) from reprocessing spent PWR fuel is a subset of SEU that has significant economic promise. AECL views the use of SEU/RU in the CANFLEX bundle as the first logical step from natural uranium. High neutron economy enables the use of low-fissile fuel in CANDU reactors, which opens up a spectrum of unique fuel-cycle opportunities that exploit the synergism between CANDU reactors and LWRs. At one end of this spectrum is the use of materials from conventional reprocessing: CANDU reactors can utilize the RU directly without re-enrichment, the plutonium as conventional Mixed-oxide (MOX) fuel, and the actinide waste mixed with plutonium in an inert-matrix carrier. At the other end of the spectrum is the DUPIC cycle, employing only thermal-mechanical processes to convert spent LWR fuel into CANDU fuel, with no purposeful separation of isotopes from the fuel, and possessing a high degree of proliferation resistance. Between these two extremes are other advanced recycling options that offer particular advantages in exploiting the

  9. CANDU fuel-cycle vision

    International Nuclear Information System (INIS)

    Boczar, P.G

    1998-05-01

    The fuel-cycle path chosen by a particular country will depend on a range of local and global factors. The CANDU reactor provides the fuel-cycle flexibility to enable any country to optimize its fuel-cycle strategy to suit its own needs. AECL has developed the CANFLEX fuel bundle as the near-term carrier of advanced fuel cycles. A demonstration irradiation of 24 CANFLEX bundles in the Point Lepreau power station, and a full-scale critical heat flux (CHF) test in water are planned in 1998, before commercial implementation of CANFLEX fuelling. CANFLEX fuel provides a reduction in peak linear element ratings, and a significant enhancement in thermalhydraulic performance. Whereas natural uranium fuel provides many advantages, the use of slightly enriched uranium (SEU) in CANDU reactors offers even lower fuel-cycle costs and other benefits, such as uprating capability through flattening the channel power distribution across the core. Recycled uranium (RU) from reprocessing spent PWR fuel is a subset of SEU that has significant economic promise. AECL views the use of SEU/RU in the CANFLEX bundle as the first logical step from natural uranium. High neutron economy enables the use of low-fissile fuel in CANDU reactors, which opens up a spectrum of unique fuel-cycle opportunities that exploit the synergism between CANDU reactors and LWRs. At one end of this spectrum is the use of materials from conventional reprocessing: CANDU reactors can utilize the RU directly without reenrichment, the plutonium as conventional mixed-oxide (MOX) fuel, and the actinide waste mixed with plutonium in an inert-matrix carrier. At the other end of the spectrum is the DUPIC cycle, employing only thermal-mechanical processes to convert spent LWR fuel into CANDU fuel, with no purposeful separation of isotopes from the fuel, and possessing a high degree of proliferation resistance. Between these two extremes are other advanced recycling options that offer particular advantages in exploiting the

  10. Establishment and prioritization of relevant factors to the safety of fuel cycle facilities non reactor through dynamics archetypes evaluation; Estabelecimento e priorizacao de fatores relevantes para a seguranca de instalacoes do ciclo do combustivel exceto o reator atraves da avaliacao da dinamica de arquetipos

    Energy Technology Data Exchange (ETDEWEB)

    Sousa, Anna Leticia Barbosa de

    2012-07-01

    The present work aims to establish and prioritize factors that are important to the safety of nuclear fuel cycle facilities in order to model, analyze and design safety as a physical system, employing systemic models in an innovative way. This work takes into consideration the fact that models that use adaptations of methodologies for nuclear reactors will not properly work due to the specificities of fuel cycle facilities. Based on the fundamentals of the theory of systems, the four levels of system thinking, and the relationship of eight socio technical factors, a mental model has been developed for safety management in the nuclear fuel cycle context. From this conceptual model, safety archetypes were constructed in order to identify and highlight the processes of change and decision making that allow the system to migrate to a state of loss of safety. After that, stock and flow diagrams were created so that their behavior could be assessed by the system's dynamics. The results from the analysis using the model that simulates the dynamic behavior of the variables (socio technical factors) indicated, as expected, that the system's dynamics proved to be an appropriate and efficient tool for modeling fuel cycle safety as an emergent property. (author)

  11. Cycle design flexibility for the Browns Ferry Nuclear Plant

    International Nuclear Information System (INIS)

    Beu, T.D.; Keys, T.A.; Gardner, D.R.

    1986-01-01

    Fuel cycle length flexibility is being included in the cycle designs of the Browns Ferry Nuclear Plant owned and operated by the Tennessee Valley Authority. Large end-of-cycle exposure windows are accommodated by adjusting the length of end-of-cycle coastdowns. Constraints on cycle designs are being lessened by application of innovative core loading strategies and through implementation of advanced fuel designs. Changes in design bases are evaluated relatively quickly and factored into cycle designs in order to maintain or improve performance

  12. Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients

    NARCIS (Netherlands)

    Kupka, RW; Luckenbaugh, DA; Post, RM; Suppes, T; Altshuler, LL; Keck, PE; Frye, MA; Denicoff, KD; Grunze, H; Leverich, GS; McElroy, SL; Walden, J; Nolen, WA

    Objective: To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective. Method: Outpatients with bipolar I disorder (N = 419), bipolar II disorder (N = 104),

  13. Exploring cycle crash characteristics in Malaysia

    Directory of Open Access Journals (Sweden)

    Hamzah A.

    2017-01-01

    Full Text Available This paper explains the cycle road crash trend, characteristics and injuries in Malaysia. It analyses the in-depth road crash investigation data collected by the Royal Malaysian Police which was made available to MIROS crash database. Fatality data was utilized due to its consistency. Cycle casualties reflected a continual downward pattern for year 2009 to 2014 in which the number of cycle crash involvement reduced by 49% and fatalities dropped by 42%. Among the prevalent factors of cycle fatalities are >60 age group, federal and state roads and straight road sections, rural and small towns, evening peak hours, and mainly involving cars and motorcycles. It is hoped that all these information would spark interests to improve cycle safety in Malaysia.

  14. Combined Turbine and Cycle Optimization for Organic Rankine Cycle Power Systems—Part A

    DEFF Research Database (Denmark)

    Meroni, Andrea; La Seta, Angelo; Andreasen, Jesper Graa

    2016-01-01

    Axial-flow turbines represent a well-established technology for a wide variety of power generation systems. Compactness, flexibility, reliability and high efficiency have been key factors for the extensive use of axial turbines in conventional power plants and, in the last decades, in organic...... Rankine cycle power systems. In this two-part paper, an overall cycle model and a model of an axial turbine were combined in order to provide a comprehensive preliminary design of the organic Rankine cycle unit, taking into account both cycle and turbine optimal designs. Part A presents the preliminary...

  15. Life cycle management (LCM)

    DEFF Research Database (Denmark)

    Remmen, Arne; Thrane, Mikkel

    2004-01-01

    The chapter gives an introduction to Life Cycle Management (LCM) and shows how LCM can be practiced in different contexts and at different ambition levels.......The chapter gives an introduction to Life Cycle Management (LCM) and shows how LCM can be practiced in different contexts and at different ambition levels....

  16. Nutrient cycling strategies.

    NARCIS (Netherlands)

    Breemen, van N.

    1995-01-01

    This paper briefly reviews pathways by which plants can influence the nutrient cycle, and thereby the nutrient supply of themselves and of their competitors. Higher or lower internal nutrient use efficiency positively feeds back into the nutrient cycle, and helps to increase or decrease soil

  17. Life Cycle Impact Assessment

    DEFF Research Database (Denmark)

    Rosenbaum, Ralph K.; Hauschild, Michael Zwicky; Boulay, Anne-Marie

    2018-01-01

    This chapter is dedicated to the third phase of an LCA study, the Life Cycle Impact Assessment (LCIA) where the life cycle inventory’s information on elementary flows is translated into environmental impact scores. In contrast to the three other LCA phases, LCIA is in practice largely automated...

  18. Rock Cycle Roulette.

    Science.gov (United States)

    Schmidt, Stan M.; Palmer, Courtney

    2000-01-01

    Introduces an activity on the rock cycle. Sets 11 stages representing the transitions of an earth material in the rock cycle. Builds six-sided die for each station, and students move to the stations depending on the rolling side of the die. Evaluates students by discussing several questions in the classroom. Provides instructional information for…

  19. Universal cycle periods

    NARCIS (Netherlands)

    Groot, de E.A. (Bert); Franses, P.H.P.H.

    2009-01-01

    We present a meta-analysis of cycles in historical economic data. The literature on stochastic and deterministic cycles in variables such as the consumer price index, employment, interest rates, commodity prices, and GDP is huge and scattered, but our meta-analysis reveals various communalities. Our

  20. Stability through cycles

    NARCIS (Netherlands)

    E.A. de Groot (Bert); Ph.H.B.F. Franses (Philip Hans)

    2006-01-01

    textabstractEconomic variables like GDP growth, employment, interest rates and consumption show signs of cyclical behavior. Many variables display multiple cycles, with lengths ranging in between 5 to even up to 100 years. We argue that multiple cycles can be associated with long-run stability of

  1. Fashion and death: Trends Cycles

    Directory of Open Access Journals (Sweden)

    Flavia Jakemiu Araújo Bortolon

    2016-12-01

    Full Text Available Fashion is composed of cycles subpostos trends that seek to eliminate the past for a new one, which makes it ephemeral and eternal at the same time. This study investigates how is the relationship between these cycles of trends over time, through a brief history of fashion, considering the theoretical rules of Simmel, Crane and Caldas. They will still be used concepts proposed by Agamben, such as: device, in order to classify the system of the fashion; contemporaneidade, to understand the action of that factor in relation to the time and profanation, to identify the capacity to maintain in the society. It is ended that the fashion, as well as the death, renews the society, it destroys and it creates the new, as a system naturalized artificially

  2. Reproductive cycles in tropical intertidal gastropods are timed around tidal amplitude cycles.

    Science.gov (United States)

    Collin, Rachel; Kerr, Kecia; Contolini, Gina; Ochoa, Isis

    2017-08-01

    Reproduction in iteroparous marine organisms is often timed with abiotic cycles and may follow lunar, tidal amplitude, or daily cycles. Among intertidal marine invertebrates, decapods are well known to time larval release to coincide with large amplitude nighttime tides, which minimizes the risk of predation. Such bimonthly cycles have been reported for few other intertidal invertebrates. We documented the reproduction of 6 gastropod species from Panama to determine whether they demonstrate reproductive cycles, whether these cycles follow a 2-week cycle, and whether cycles are timed so that larval release occurs during large amplitude tides. Two of the species ( Crepidula cf. marginalis and Nerita scabricosta ) showed nonuniform reproduction, but without clear peaks in timing relative to tidal or lunar cycles. The other 4 species show clear peaks in reproduction occurring every 2 weeks. In 3 of these species ( Cerithideopsis carlifornica var. valida, Littoraria variegata , and Natica chemnitzi ), hatching occurred within 4 days of the maximum amplitude tides. Siphonaria palmata exhibit strong cycles, but reproduction occurred during the neap tides. Strong differences in the intensity of reproduction of Cerithideopsis carlifornica , and in particular, Littoraria variegata , between the larger and smaller spring tides of a lunar month indicate that these species time reproduction with the tidal amplitude cycle rather than the lunar cycle. For those species that reproduce during both the wet and dry seasons, we found that reproductive timing did not differ between seasons despite strong differences in temperature and precipitation. Overall, we found that most (4/6) species have strong reproductive cycles synchronized with the tidal amplitude cycle and that seasonal differences in abiotic factors do not alter these cycles.

  3. Globalisation of the nuclear fuel cycle

    International Nuclear Information System (INIS)

    Rougeau, J.-P.; Durret, L.-F.

    1995-01-01

    Three main features of the globalisation of the nuclear fuel cycle are identified and discussed. The first is an increase in the scale of the nuclear fuel cycle materials and services markets in the past 20 years. This has been accompanied by a growth in the sophistication of the fuel cycle. Secondly, the nuclear industry is now more vulnerable to outside pressures; it is no longer possible to make strategic decisions on the industry within a country solely on national considerations. Thirdly, there are changes in the decision-making process at the political, regulatory, operational and industrial level which are the consequence of global factors. (UK)

  4. Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis

    Science.gov (United States)

    Kowalewski, Ashley A.; Randall, R. Lor; Lessnick, Stephen L.

    2011-01-01

    Ewing's sarcoma is a highly aggressive pediatric tumor of bone that usually contains the characteristic chromosomal translocation t(11;22)(q24;q12). This translocation encodes the oncogenic fusion protein EWS/FLI, which acts as an aberrant transcription factor to deregulate target genes necessary for oncogenesis. One key feature of oncogenic transformation is dysregulation of cell cycle control. It is therefore likely that EWS/FLI and other cooperating mutations in Ewing's sarcoma modulate the cell cycle to facilitate tumorigenesis. This paper will summarize current published data associated with deregulation of the cell cycle in Ewing's sarcoma and highlight important questions that remain to be answered. PMID:21052502

  5. Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis

    Directory of Open Access Journals (Sweden)

    Ashley A. Kowalewski

    2011-01-01

    Full Text Available Ewing's sarcoma is a highly aggressive pediatric tumor of bone that usually contains the characteristic chromosomal translocation t(11;22(q24;q12. This translocation encodes the oncogenic fusion protein EWS/FLI, which acts as an aberrant transcription factor to deregulate target genes necessary for oncogenesis. One key feature of oncogenic transformation is dysregulation of cell cycle control. It is therefore likely that EWS/FLI and other cooperating mutations in Ewing's sarcoma modulate the cell cycle to facilitate tumorigenesis. This paper will summarize current published data associated with deregulation of the cell cycle in Ewing's sarcoma and highlight important questions that remain to be answered.

  6. KOH concentration effect on cycle life of nickel-hydrogen cells. III - Cycle life test

    Science.gov (United States)

    Lim, H. S.; Verzwyvelt, S. A.

    1988-01-01

    A cycle life test of Ni/H2 cells containing electrolytes of various KOH concentrations and a sintered type nickel electrode was carried out at 23 C using a 45 min accelerated low earth orbit (LEO) cycle regime at 80 percent depth of discharge. One of three cells containing 26 percent KOH has achieved over 28,000 cycles, and the other two 19,000 cycles, without a sign of failure. Two other cells containing 31 percent KOH electrolyte, which is the concentration presently used in aerospace cells, failed after 2,979 and 3,620 cycles. This result indicates that the cycle life of the present type of Ni/H2 cells may be extended by a factor of 5 to 10 simply by lowering the KOH concentration. Long cycle life of a Ni/H2 battery at high depth-of-discharge operation is desired, particularly for an LEO spacecraft application. Typically, battery life of about 30,000 cycles is required for a five year mission in an LEO. Such a cycle life with presently available cells can be assured only at a very low depth-of-discharge operation. Results of testing already show that the cycle life of an Ni/H2 cell is tremendously improved by simply using an electrolyte of low KOH concentration.

  7. Two Quantum Polytropic Cycles

    Science.gov (United States)

    Arias-Hernández, L. A.; Morales-Serrano, A. F.

    2002-11-01

    In this work we follow the Bender et al paper [1] to study the quantum analogues of the Stirling and Ericsson polytropic cycles. In the context of the classical thermodynamics, the Stirling and Ericsson cycles correspond to reversible heat engines with two isothermal processes joined by two polytropic branches which occur in a device called regenerator. If this device is an ideal one, the efficiency of these cycles is the Carnot efficiency. Here, we introduce the quantum analogues of the Stirling and Ericsson cycles, the first one based on a double square potential well with a finite potential barrier, since in this system the tunnel effect could be the analogue to the regeneration classical process, therefore the isochoric quantum branches would really correspond to an internal energy storage, and the last one with an unknown system where the isobaric quantum processes don't induce changes in its quantum state. With these systems the quantum engines have cycles consisting of polytropic and isothermal quantum processes analogues to the corresponding classical processes. We show that in both cases the quantum cycles have an efficiency given by ηCQM = 1 - EC/EH, which is the same expression for the quantum analogue of the Carnot cycle studied by Bender.

  8. Fuel cycle management

    International Nuclear Information System (INIS)

    Herbin, H.C.

    1977-01-01

    The fuel cycle management is more and more dependent on the management of the generation means among the power plants tied to the grid. This is due mainly because of the importance taken by the nuclear power plants within the power system. The main task of the fuel cycle management is to define the refuelling pattern of the new and irradiated fuel assemblies to load in the core as a function of: 1) the differences which exist between the actual conditions of the core and what was expected for the present cycle, 2) the operating constraints and the reactor availability, 3) the technical requirements in safety and the technological limits of the fuel, 4) the economics. Three levels of fuel cycle management can be considered: 1) a long term management: determination of enrichments and expected cycle lengths, 2) a mid term management whose aim corresponds to the evaluation of the batch to load within the core as a function of both: the next cycle length to achieve and the integrated power history of all the cycles up to the present one, 3) a short term management which deals with the updating of the loaded fuel utilisations to take into account the operation perturbations, or with the alteration of the loading pattern of the next batch to respect unexpected conditions. (orig.) [de

  9. On approximating restricted cycle covers

    NARCIS (Netherlands)

    Manthey, Bodo

    2008-01-01

    A cycle cover of a graph is a set of cycles such that every vertex is part of exactly one cycle. An $L$-cycle cover is a cycle cover in which the length of every cycle is in the set $L$. The weight of a cycle cover of an edge-weighted graph is the sum of the weights of its edges. We come close to

  10. International Business Cycle Accounting

    OpenAIRE

    Keisuke Otsu

    2009-01-01

    In this paper, I extend the business cycle accounting method a la Chari, Kehoe and McGrattan (2007) to a two-country international business cycle model and quantify the effect of the disturbances in relevant markets on the business cycle correlation between Japan and the US over the 1980-2008 period. This paper finds that disturbances in the labor market and production efficiency are important in accounting for the recent increase in the cross-country output correlation. If international fina...

  11. Life Cycle Sustainability Dashboard

    DEFF Research Database (Denmark)

    Traverso, Marzia; Finkbeiner, Matthias; Jørgensen, Andreas

    2012-01-01

    One method to assess the sustainability performance of products is life cycle sustainability assessment (LCSA), which assesses product performance considering the environmental,economic, and social dimensions of the life cycle. The results of LCSA can be used to compare different products...... of sustainability is the communicability of the results by means of a graphical representation (a cartogram), characterized by a suitable chromatic scale and ranking score. The integration of LCSA and the dashboard of sustainability into a so-called Life Cycle Sustainability Dashboard (LCSD) is described here...

  12. STUDYING BUSINESS CYCLES SYNCHRONIZATION

    Directory of Open Access Journals (Sweden)

    N. Servetnyk

    2014-06-01

    Full Text Available The paper researches business cycles synchronization. The fluctuations in post-Soviet countries are considered. The study examines different measures of synchronization in groups of countries according to some criteria.

  13. The thorium fuel cycle

    International Nuclear Information System (INIS)

    Merz, E.R.

    1977-01-01

    The utilization of the thorium fuel cycle has long since been considered attractive owing to the excellent neutronic characteristics of 233 U, and the widespread and cheap thorium resources. Rapidly increasing uranium prices, public reluctance for widespread Pu recycling and expected delays for the market penetration of fast breeders have led to a reconsideration of the thorium fuel cycle merits. In addition, problems associated with reprocessing and waste handling, particularly with re-fabrication by remote handling of 233 U, are certainly not appreciably more difficult than for Pu recycling. To divert from uranium as a nuclear energy source it seems worth while intensifying future efforts for closing the Th/ 233 U fuel cycle. HTGRs are particularly promising for economic application. However, further research and development activities should not concentrate on this reactor type alone. Light- and heavy-water-moderated reactors, and even future fast breeders, may just as well take advantage of a demonstrated thorium fuel cycle. (author)

  14. Educational Business Cycles

    DEFF Research Database (Denmark)

    Tepe, Markus; Vanhuysse, Pieter

    Strong institutional constraints and better-informed voters may lead re-election seeking incumbents to shift the use of political business cycle mechanisms away from monetary and fiscal policy towards other policy domains that are more easily manipulable, targetable, and timeable. We investigate...... teacher employment patterns at the state level in Germany and find strong evidence of cycling mechanisms, in the form of electioneering and honeymooning. Against a backdrop of a continuously shrinking total teachers' pool, German state-level incumbents accelerate the hiring of new teachers during election...... periods and partly reverse this during politically safer points in the electoral cycle. Cycles are mediated by issue salience: heightened attention to German public schooling after the notorious PISA-2000 tests further strengthens the manipulation of new teacher hiring for electoral purposes....

  15. Educational Business Cycles

    DEFF Research Database (Denmark)

    Tepe, Markus; Vanhuysse, Pieter

    2009-01-01

    Strong institutional constraints and better-informed voters may lead re-election seeking incumbents to shift the use of political business cycle mechanisms away from monetary and fiscal policy towards other policy domains that are more easily manipulable, targetable, and timeable. We investigate...... teacher employment patterns at the state level in Germany and find strong evidence of cycling mechanisms, in the form of electioneering and honeymooning. Against a backdrop of a continuously shrinking total teachers' pool, German state-level incumbents accelerate the hiring of new teachers during election...... periods and partly reverse this during politically safer points in the electoral cycle. Cycles are mediated by issue salience: heightened attention to German public schooling after the notorious PISA-2000 tests further strengthens the manipulation of new teacher hiring for electoral purposes....

  16. Cycles in graphs

    CERN Document Server

    Alspach, BR

    1985-01-01

    This volume deals with a variety of problems involving cycles in graphs and circuits in digraphs. Leading researchers in this area present here 3 survey papers and 42 papers containing new results. There is also a collection of unsolved problems.

  17. The Rock Cycle

    Science.gov (United States)

    Singh, Raman J.; Bushee, Jonathan

    1977-01-01

    Presents a rock cycle diagram suitable for use at the secondary or introductory college levels which separates rocks formed on and below the surface, includes organic materials, and separates products from processes. (SL)

  18. Extended fuel cycle length

    International Nuclear Information System (INIS)

    Bruyere, M.; Vallee, A.; Collette, C.

    1986-09-01

    Extended fuel cycle length and burnup are currently offered by Framatome and Fragema in order to satisfy the needs of the utilities in terms of fuel cycle cost and of overall systems cost optimization. We intend to point out the consequences of an increased fuel cycle length and burnup on reactor safety, in order to determine whether the bounding safety analyses presented in the Safety Analysis Report are applicable and to evaluate the effect on plant licensing. This paper presents the results of this examination. The first part indicates the consequences of increased fuel cycle length and burnup on the nuclear data used in the bounding accident analyses. In the second part of this paper, the required safety reanalyses are presented and the impact on the safety margins of different fuel management strategies is examined. In addition, systems modifications which can be required are indicated

  19. Fuel cycle studies

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    Programs are being conducted in the following areas: advanced solvent extraction techniques, accident consequences, fuel cycles for nonproliferation, pyrochemical and dry processes, waste encapsulation, radionuclide transport in geologic media, hull treatment, and analytical support for LWBR

  20. Traffic Signal Cycle Lengths

    Data.gov (United States)

    Town of Chapel Hill, North Carolina — Traffic signal location list for the town of Chapel Hill. This data set includes light cycle information as well as as intersection information.The Town of Chapel...

  1. International Real Business Cycles

    OpenAIRE

    Mario J. Crucini

    2006-01-01

    This paper is a non-technical review of research developments in the international real business cycle literature. International business cycle facts are summarize with particular attention to the sources of output variance from the expenditure side of the NIPA and the production side, using a familiar neoclassical production function. Theoretical developments focus on the how consumption smoothing and investment dynamics shape the current account; the search for sources and propagation mecha...

  2. The global carbon cycle

    International Nuclear Information System (INIS)

    Maier-Reimer, E.

    1991-01-01

    Basic concepts of the global carbon cycle on earth are described; by careful analyses of isotopic ratios, emission history and oceanic ventilation rates are derived, which provide crucial tests for constraining and calibrating models. Effects of deforestation, fertilizing, fossil fuel burning, soil erosion, etc. are quantified and compared, and the oceanic carbon process is evaluated. Oceanic and terrestrial biosphere modifications are discussed and a carbon cycle model is proposed

  3. IFR fuel cycle

    International Nuclear Information System (INIS)

    Battles, J.E.; Miller, W.E.; Lineberry, M.J.; Phipps, R.D.

    1992-01-01

    The next major milestone of the IFR program is engineering-scale demonstration of the pyroprocess fuel cycle. The EBR-II Fuel Cycle Facility has just entered a startup phase, which includes completion of facility modifications and installation and cold checkout of process equipment. This paper reviews the development of the electrorefining pyroprocess, the design and construction of the facility for the hot demonstration, the design and fabrication of the equipment, and the schedule and initial plan for its operation

  4. Hat cycle dynamic simulation

    International Nuclear Information System (INIS)

    Trucco, A.; Corallo, C.; Pini Prato, A.; Porro, S.

    1999-01-01

    Among the innovative cycle recently proposed in literature, the Humid Air Turbine Cycle - Hat better seems to fulfil the main energy market requirements of today: High efficiency in a large power ranger, low pollution, low specific capital cost. The previous results of an analysis at partial load and transient conditions are here presented, where the Hat plant has been simulated using the original model implemented in LEGO environment [it

  5. Quantifying the Adaptive Cycle.

    Directory of Open Access Journals (Sweden)

    David G Angeler

    Full Text Available The adaptive cycle was proposed as a conceptual model to portray patterns of change in complex systems. Despite the model having potential for elucidating change across systems, it has been used mainly as a metaphor, describing system dynamics qualitatively. We use a quantitative approach for testing premises (reorganisation, conservatism, adaptation in the adaptive cycle, using Baltic Sea phytoplankton communities as an example of such complex system dynamics. Phytoplankton organizes in recurring spring and summer blooms, a well-established paradigm in planktology and succession theory, with characteristic temporal trajectories during blooms that may be consistent with adaptive cycle phases. We used long-term (1994-2011 data and multivariate analysis of community structure to assess key components of the adaptive cycle. Specifically, we tested predictions about: reorganisation: spring and summer blooms comprise distinct community states; conservatism: community trajectories during individual adaptive cycles are conservative; and adaptation: phytoplankton species during blooms change in the long term. All predictions were supported by our analyses. Results suggest that traditional ecological paradigms such as phytoplankton successional models have potential for moving the adaptive cycle from a metaphor to a framework that can improve our understanding how complex systems organize and reorganize following collapse. Quantifying reorganization, conservatism and adaptation provides opportunities to cope with the intricacies and uncertainties associated with fast ecological change, driven by shifting system controls. Ultimately, combining traditional ecological paradigms with heuristics of complex system dynamics using quantitative approaches may help refine ecological theory and improve our understanding of the resilience of ecosystems.

  6. The Nuclear Fuel Cycle

    International Nuclear Information System (INIS)

    2011-08-01

    This brochure describes the nuclear fuel cycle, which is an industrial process involving various activities to produce electricity from uranium in nuclear power reactors. The cycle starts with the mining of uranium and ends with the disposal of nuclear waste. The raw material for today's nuclear fuel is uranium. It must be processed through a series of steps to produce an efficient fuel for generating electricity. Used fuel also needs to be taken care of for reuse and disposal. The nuclear fuel cycle includes the 'front end', i.e. preparation of the fuel, the 'service period' in which fuel is used during reactor operation to generate electricity, and the 'back end', i.e. the safe management of spent nuclear fuel including reprocessing and reuse and disposal. If spent fuel is not reprocessed, the fuel cycle is referred to as an 'open' or 'once-through' fuel cycle; if spent fuel is reprocessed, and partly reused, it is referred to as a 'closed' nuclear fuel cycle.

  7. Thorium fuel cycle analysis

    Energy Technology Data Exchange (ETDEWEB)

    Yamaji, K [Central Research Inst. of Electric Power Industry, Tokyo (Japan)

    1980-07-01

    Systems analysis of the thorium cycle, a nuclear fuel cycle accomplished by using thorium, is reported in this paper. Following a brief review on the history of the thorium cycle development, analysis is made on the three functions of the thorium cycle; (1) auxiliary system of U-Pu cycle to save uranium consumption, (2) thermal breeder system to exert full capacity of the thorium resource, (3) symbiotic system to utilize special features of /sup 233/U and neutron sources. The effects of the thorium loading in LWR (Light Water Reactor), HWR (Heavy Water Reactor) and HTGR (High Temperature Gas-cooled Reactor) are considered for the function of auxiliary system of U-Pu cycle. Analysis is made to find how much uranium is saved by /sup 233/U recycling and how the decrease in Pu production influences the introduction of FBR (Fast Breeder Reactor). Study on thermal breeder system is carried out in the case of MSBR (Molten Salt Breeder Reactor). Under a certain amount of fissile material supply, the potential system expansion rate of MSBR, which is determined by fissile material balance, is superior to that of FBR because of the smaller specific fissile inventory of MSBR. For symbiotic system, three cases are treated; i) nuclear heat supply system using HTGR, ii) denatured fuel supply system for nonproliferation purpose, and iii) hybrid system utilizing neutron sources other than fission reactor.

  8. Cycles and Common Cycles in Property and Related Sectors

    OpenAIRE

    Peijie Wang

    2003-01-01

    This paper examines cycles and common cycles in the property market and the economy. While focusing on common cycles, the study also incorporates common trends in the meantime, so it covers the whole spectrum of dynamic analysis. It has been found that property shares common cycles, particularly with those sectors that are the user markets of property. The mechanisms of common cycles and the relative magnitudes of cycles of the sectors related to property are discussed to shed light on proper...

  9. Large-scale fuel cycle centres

    International Nuclear Information System (INIS)

    Smiley, S.H.; Black, K.M.

    1977-01-01

    material controls on an international scale, and the lack of a technological requirement for co-location (on a national basis) of fuel cycle facilities, has led to the concept of the multinational fuel cycle facility. However, the establishment of such a facility requires resolution of a number of unusual factors, broadly characterized as: (1) Administrative and organizational; (2) Economic and financial; (3) Technical; and (4) Operational. Each of these broad areas has been examined on a preliminary basis for a particular geographic region on behalf of a multinational group of organizations to determine the feasibility of the concept and to identify the problems that need to be overcome to ensure its ultimate success. (author)

  10. Environmental correlates of cycling: Evaluating urban form and location effects based on Danish micro-data

    DEFF Research Database (Denmark)

    Nielsen, Thomas Alexander Sick; Olafsson, Anton Stahl; Carstensen, Trine Agervig

    2013-01-01

    The paper analyses the environmental correlates of cycling based on Danish transportation and urban form micro-data. The results show that established walkability factors such as density, connectivity and diversity are related to cycling, but access to retail concentrations/centres, public...... and the distance cycled. A high probability of cycling generally implies short cycling distances leading to non-uniform, non-monotonous relationship between environmental indicators such as walkability and cycling....

  11. A BWR 24-month cycle analysis using multicycle techniques

    International Nuclear Information System (INIS)

    Hartley, K.D.

    1993-01-01

    Boiling water reactor (BWR) fuel cycle design analyses have become increasingly challenging in the past several years. As utilities continue to seek improved capacity factors, reduced power generation costs, and reduced outage costs, longer cycle lengths and fuel design optimization become important considerations. Accurate multicycle analysis techniques are necessary to determine the viability of fuel designs and cycle operating strategies to meet reactor operating requirements, e.g., meet thermal and reactivity margin constraints, while minimizing overall fuel cycle costs. Siemens Power Corporation (SPC), Nuclear Division, has successfully employed multi-cycle analysis techniques with realistic rodded cycle depletions to demonstrate equilibrium fuel cycle performance in 24-month cycles. Analyses have been performed by a BWR/5 reactor, at both rated and uprated power conditions

  12. Multiparameter Cell Cycle Analysis.

    Science.gov (United States)

    Jacobberger, James W; Sramkoski, R Michael; Stefan, Tammy; Woost, Philip G

    2018-01-01

    Cell cycle cytometry and analysis are essential tools for studying cells of model organisms and natural populations (e.g., bone marrow). Methods have not changed much for many years. The simplest and most common protocol is DNA content analysis, which is extensively published and reviewed. The next most common protocol, 5-bromo-2-deoxyuridine S phase labeling detected by specific antibodies, is also well published and reviewed. More recently, S phase labeling using 5'-ethynyl-2'-deoxyuridine incorporation and a chemical reaction to label substituted DNA has been established as a basic, reliable protocol. Multiple antibody labeling to detect epitopes on cell cycle regulated proteins, which is what this chapter is about, is the most complex of these cytometric cell cycle assays, requiring knowledge of the chemistry of fixation, the biochemistry of antibody-antigen reactions, and spectral compensation. However, because this knowledge is relatively well presented methodologically in many papers and reviews, this chapter will present a minimal Methods section for one mammalian cell type and an extended Notes section, focusing on aspects that are problematic or not well described in the literature. Most of the presented work involves how to segment the data to produce a complete, progressive, and compartmentalized cell cycle analysis from early G1 to late mitosis (telophase). A more recent development, using fluorescent proteins fused with proteins or peptides that are degraded by ubiquitination during specific periods of the cell cycle, termed "Fucci" (fluorescent, ubiquitination-based cell cycle indicators) provide an analysis similar in concept to multiple antibody labeling, except in this case cells can be analyzed while living and transgenic organisms can be created to perform cell cycle analysis ex or in vivo (Sakaue-Sawano et al., Cell 132:487-498, 2007). This technology will not be discussed.

  13. Innovation in the fuel cycle industry

    International Nuclear Information System (INIS)

    Lamorlette, Guy

    1998-01-01

    The fuel cycle industry will have to adapt to the production of new fuel and in the same time will have to improve its performance. Innovation will be a key factor of success. Innovation must be driven by the needs of the fuel cycle industry to achieve. The fuel cycle requirement of tomorrow, Innovative processes for mining high grade uranium, Innovative enrichment process, Sorting the pellets at Melox plant, Innovation in action, and Innovative waste management in la Hague are presented. A number of innovative solutions are already implemented and are in action on industrial facilities. As problems are becoming more and more tough to address, international cooperation will be required. The fuel cycle industry, as a part of the nuclear power industry, is committed to seek improvements through performance upgrade and innovation. (Cho. G. S.). 10 refs., 4 figs

  14. The nuclear fuel cycle versus the carbon cycle

    International Nuclear Information System (INIS)

    Ewing, R.C.

    2005-01-01

    Nuclear power provides approximately 17% of the world's electricity, which is equivalent to a reduction in carbon emissions of ∼0.5 gigatonnes (Gt) of C/yr. This is a modest reduction as compared with global emissions of carbon, ∼7 Gt C/yr. Most analyses suggest that in order to have a significant and timely impact on carbon emissions, carbon-free sources, such as nuclear power, would have to expand total production of energy by factors of three to ten by 2050. A three-fold increase in nuclear power capacity would result in a projected reduction in carbon emissions of 1 to 2 Gt C/yr, depending on the type of carbon-based energy source that is displaced. This three-fold increase utilizing present nuclear technologies would result in 25,000 metric tonnes (t) of spent nuclear fuel (SNF) per year, containing over 200 t of plutonium. This is compared to a present global inventory of approximately 280,000 t of SNF and >1,700 t of Pu. A nuclear weapon can be fashioned from as little as 5 kg of 239 Pu. However, there is considerable technological flexibility in the nuclear fuel cycle. There are three types of nuclear fuel cycles that might be utilized for the increased production of energy: open, closed, or a symbiotic combination of different types of reactor (such as, thermal and fast neutron reactors). The neutron energy spectrum has a significant effect on the fission product yield, and the consumption of long-lived actinides, by fission, is best achieved by fast neutrons. Within each cycle, the volume and composition of the high-level nuclear waste and fissile material depend on the type of nuclear fuel, the amount of burn-up, the extent of radionuclide separation during reprocessing, and the types of materials used to immobilize different radionuclides. As an example, a 232 Th-based fuel cycle can be used to breed fissile 233 U with minimum production of Pu. In this paper, I will contrast the production of excess carbon in the form of CO 2 from fossil fuels with

  15. DETERMINANTS OF ENTERPRISES LIFE CYCLE IN MODERN CONDITIONS OF DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Alla Polianska

    2016-03-01

    Full Text Available In the article the theoretical basis of organization life cycle research as well as the particularly of the organization life cycle concept implementation for solving of modern targets of enterprises and organizations development are highlighted. The determinants of one life cycle stage transformation to the other at the enterprises, that allows to better understand the conditions of its functioning and to identify factors that affect the viability of the company and its duration, are considered. Management technologies at different stages of organizations life cycle are proposed. Keywords: enterprise, development, organizations life cycle, determinants, Oil and Gas company JEL: M 20

  16. Optimum heat power cycles for specified boundary conditions

    International Nuclear Information System (INIS)

    Ibrahim, O.M.; Klein, S.A.; Mitchell, J.W.

    1991-01-01

    In this paper optimization of the power output of Carnot and closed Brayton cycles is considered for both finite and infinite thermal capacitance rates of the external fluid streams. The method of Lagrange multipliers is used to solve for working fluid temperatures that yield maximum power. Analytical expressions for the maximum power and the cycle efficiency at maximum power are obtained. A comparison of the maximum power from the two cycles for the same boundary conditions, i.e., the same heat source/sink inlet temperatures, thermal capacitance rates, and heat exchanger conductances, shows that the Brayton cycle can produce more power than the Carnot cycle. This comparison illustrates that cycles exist that can produce more power than the Carnot cycle. The optimum heat power cycle, which will provide the upper limit of power obtained from any thermodynamic cycle for specified boundary conditions and heat exchanger conductances is considered. The optimum heat power cycle is identified by optimizing the sum of the power output from a sequence of Carnot cycles. The shape of the optimum heat power cycle, the power output, and corresponding efficiency are presented. The efficiency at maximum power of all cycles investigated in this study is found to be equal to (or well approximated by) η = 1 - sq. root T L.in /φT H.in where φ is a factor relating the entropy changes during heat rejection and heat addition

  17. Characterization of oocyte retrieval cycles with empty zona pellucida.

    Science.gov (United States)

    Oride, Aki; Kanasaki, Haruhiko; Hara, Tomomi; Ohta, Hiroko; Kyo, Satoru

    2018-01-01

    To identify the factors that characterize cycles with empty zona pellucida (EZP). Thirty-six oocyte retrieval cycles from which EZP were collected and another 36 cycles from which no EZP was collected were compared. The patients were divided into three groups: those with no EZP collected during any cycle, those with EZP collected during all cycles, and those experiencing cycles both with and without EZP. The mean number of oocytes collected per cycle was higher in the cycles with EZP than without EZP. The fertilization rate of the collected oocytes and the rate of good embryo formation were significantly lower in the cycles with EZP. No significant difference was observed between the three groups in terms of age, number of oocytes collected, or hormone levels before and after the oocyte retrieval. The fertilization and pregnancy rates were highest in the patients with no EZP being collected during any cycle, followed by those experiencing cycles both with and without EZP, and then by those with EZP collected during all cycles. The observation of lower fertilization, poor embryo formation, and a low pregnancy rate in the patients with EZP suggests the poor quality of oocytes that were collected with EZP in the same cycle.

  18. Tracking the business cycle of the Euro area: A multivariate model-based band-pass filter

    NARCIS (Netherlands)

    Azevedo, J.M.; Koopman, S.J.; Rua, A.

    2006-01-01

    This article proposes a multivariate bandpass filter based on the trend plus cycle decomposition model. The underlying multivariate dynamic factor model relies on specific formulations for trend and cycle components and produces smooth business cycle indicators with bandpass filter properties.

  19. Historicising the Hydrosocial Cycle

    Directory of Open Access Journals (Sweden)

    Jeremy J. Schmidt

    2014-02-01

    Full Text Available This paper examines the historical claims made in support of the hydrosocial cycle. In particular, it considers how arguments advancing the hydrosocial cycle make historical claims regarding modernist conceptions of what water is (i.e. H2O and its fit with society. The paper gives special emphasis to the society/nature dualism and to the notion of agency as key sites of contest in arguments regarding the hydrosocial cycle. It finds that, while several versions of the hydrosocial cycle seek to advance a political ecology more sensitive to non-human actions, these same accounts often do not address the robust account of non-human agency in the historical record. Evidence is presented regarding water’s agency amongst late 19th and early 20th century architects of key water management norms in the United States. This evidence troubles accounts of the hydrosocial cycle that critique the US experience and suggests new directions for rethinking the role of historical and institutional norms in water policy.

  20. Superfluid thermodynamic cycle refrigerator

    Science.gov (United States)

    Swift, Gregory W.; Kotsubo, Vincent Y.

    1992-01-01

    A cryogenic refrigerator cools a heat source by cyclically concentrating and diluting the amount of .sup.3 He in a single phase .sup.3 He-.sup.4 He solution. The .sup.3 He in superfluid .sup.4 He acts in a manner of an ideal gas in a vacuum. Thus, refrigeration is obtained using any conventional thermal cycle, but preferably a Stirling or Carnot cycle. A single phase solution of liquid .sup.3 He at an initial concentration in superfluid .sup.4 He is contained in a first variable volume connected to a second variable volume through a superleak device that enables free passage of .sup.4 He while restricting passage of .sup.3 He. The .sup.3 He is compressed (concentrated) and expanded (diluted) in a phased manner to carry out the selected thermal cycle to remove heat from the heat load for cooling below 1 K.

  1. The nuclear fuel cycle

    International Nuclear Information System (INIS)

    Patarin, L.

    2002-01-01

    This book treats of the different aspects of the industrial operations linked with the nuclear fuel, before and after its use in nuclear reactors. The basis science of this nuclear fuel cycle is chemistry. Thus a recall of the elementary notions of chemistry is given in order to understand the phenomena involved in the ore processing, in the isotope enrichment, in the fabrication of fuel pellets and rods (front-end of the cycle), in the extraction of recyclable materials (residual uranium and plutonium), and in the processing and conditioning of wastes (back-end of the fuel cycle). Nuclear reactors produce about 80% of the French electric power and the Cogema group makes 40% of its turnover at the export. Thus this book contains also some economic and geopolitical data in order to clearly position the stakes. The last part, devoted to the management of wastes, presents the solutions already operational and also the research studies in progress. (J.S.)

  2. Fuel cycle based safeguards

    International Nuclear Information System (INIS)

    De Montmollin, J.M.; Higinbotham, W.A.; Gupta, D.

    1985-07-01

    In NPT safeguards the same model approach and absolute-quantity inspection goals are applied at present to all similar facilities, irrespective of the State's fuel cycle. There is a continuing interest and activity on the part of the IAEA in new NPT safeguards approaches that more directly address a State's nuclear activities as a whole. This fuel cycle based safeguards system is expected to a) provide a statement of findings for the entire State rather than only for individual facilities; b) allocate inspection efforts so as to reflect more realistically the different categories of nuclear materials in the different parts of the fuel cycle and c) provide more timely and better coordinated information on the inputs, outputs and inventories of nuclear materials in a State. (orig./RF) [de

  3. The nuclear fuel cycle

    International Nuclear Information System (INIS)

    Jones, P.M.S.

    1987-01-01

    This chapter explains the distinction between fissile and fertile materials, examines briefly the processes involved in fuel manufacture and management, describes the alternative nuclear fuel cycles and considers their advantages and disadvantages. Fuel management is usually divided into three stages; the front end stage of production and fabrication, the back end stage which deals with the fuel after it is removed from the reactor (including reprocessing and waste treatment) and the stage in between when the fuel is actually in the reactor. These stages are illustrated and explained in detail. The plutonium fuel cycle and thorium-uranium-233 fuel cycle are explained. The differences between fuels for thermal reactors and fast reactors are explained. (U.K.)

  4. CO2 cycle

    Science.gov (United States)

    Titus, Timothy N.; Byrne, Shane; Colaprete, Anthony; Forget, Francois; Michaels, Timothy I.; Prettyman, Thomas H.

    2017-01-01

    This chapter discusses the use of models, observations, and laboratory experiments to understand the cycling of CO2 between the atmosphere and seasonal Martian polar caps. This cycle is primarily controlled by the polar heat budget, and thus the emphasis here is on its components, including solar and infrared radiation, the effect of clouds (water- and CO2-ice), atmospheric transport, and subsurface heat conduction. There is a discussion about cap properties including growth and regression rates, albedos and emissivities, grain sizes and dust and/or water-ice contamination, and curious features like cold gas jets and araneiform (spider-shaped) terrain. The nature of the residual south polar cap is discussed as well as its long-term stability and ability to buffer atmospheric pressures. There is also a discussion of the consequences of the CO2 cycle as revealed by the non-condensable gas enrichment observed by Odyssey and modeled by various groups.

  5. Political Budget Cycles

    DEFF Research Database (Denmark)

    Aaskoven, Lasse; Lassen, David Dreyer

    2017-01-01

    The political budget cycle—how elections affect government fiscal policy—is one of the most studied subjects in political economy and political science. The key theoretical question is whether incumbent governments can time or structure public finances in ways that improve their chances of reelec......The political budget cycle—how elections affect government fiscal policy—is one of the most studied subjects in political economy and political science. The key theoretical question is whether incumbent governments can time or structure public finances in ways that improve their chances...... on political budget cycles have recently focused on conditions under which such cycles are likely to obtain. Much recent research focuses on subnational settings, allowing comparisons of governments in similar institutional environments, and a consensus on the presences of cycles in public finances...

  6. Theory of limit cycles

    CERN Document Server

    Ye, Yan-Qian; Lo, Chi Y

    1986-01-01

    Over the past two decades the theory of limit cycles, especially for quadratic differential systems, has progressed dramatically in China as well as in other countries. This monograph, updating the 1964 first edition, includes these recent developments, as revised by eight of the author's colleagues in their own areas of expertise. The first part of the book deals with limit cycles of general plane stationary systems, including their existence, nonexistence, stability, and uniqueness. The second section discusses the global topological structure of limit cycles and phase-portraits of quadratic systems. Finally, the last section collects important results that could not be included under the subject matter of the previous two sections or that have appeared in the literature very recently. The book as a whole serves as a reference for college seniors, graduate students, and researchers in mathematics and physics.

  7. The DUPIC alternative for backend fuel cycle

    International Nuclear Information System (INIS)

    Lee, J.S.; Yang, M.S.; Park, H.S.; Boczar, P.; Sullivan, J.; Gadsby, R.D.

    1997-01-01

    The DUPIC fuel cycle was conceived as an alternative to the conventional fuel cycle backed options, with a view to multiple benefits expectable from burning spent PWR fuel again in CANDU reactors. It is based on the basic idea that the bulk of spent PWR fuel can be directly refabricated into a reusable fuel for CANDU of which high efficiency in neutron utilization would exhaustively burn the fissile remnants in the spent PWR fuel to a level below that of natural uranium. Such ''burn again'' strategy of the DUPIC fuel cycle implies that the spent PWR fuel will become CANDU fuel of higher burnup with relevant benefits such as spent PWR fuel disposition, saving of natural uranium fuel, etc. A salient feature of the DUPIC fuel cycle is neither the fissile content nor the bulk radioactivity is separated from the DUPIC mass flow which must be contained and shielded all along the cycle. This feature can be considered as a factor of proliferation resistance by deterrence against access to sensitive materials. It means also the requirement for remote systems technologies for DUPIC fuel operation. The conflicting aspects between better safeguardability and harder engineering problems of the radioactive fuel operation may be the important reason why the decades' old concept, since INFCE, of ''hot'' fuel cycle has not been pursued with much progress. In this context, the DUPIC fuel cycle could be a live example for development of proliferation resistant fuel cycle. As the DUPIC fuel cycle looks for synergism of fuel linkage from PWR to CANDU (or in broader sense LWR to HWR), Korea occupies a best position for DUPIC exercise with her unique strategy of reactor mix of both reactor types. But the DUPIC benefits can be extended to global bonus, expectable from successful development of the technology. (author)

  8. The thorium fuel cycle

    International Nuclear Information System (INIS)

    Merz, E.R.

    1977-01-01

    The utilization of the thorium fuel cycle has long since been considered attractive due to the excellent neutronic characteristics of 233 U, and the widespread and cheap thorium resources. Although the uranium ore as well as the separative work requirements are usually lower for any thorium-based fuel cycle in comparison to present uranium-plutonium fuel cycles of thermal water reactors, interest by nuclear industry has hitherto been marginal. Fast increasing uranium prices, public reluctance against widespread Pu-recycling and expected retardations for the market penetration of fast breeders have led to a reconsideration of the thorium fuel cycle merits. In addition, it could be learned in the meantime that problems associated with reprocessing and waste handling, but particularly with a remote refabrication of 233 U are certainly not appreciably more difficult than for Pu-recycling. This may not only be due to psychological constraints but be based upon technological as well as economical facts, which have been mostly neglected up till now. In order to diversify from uranium as a nuclear energy source it seems to be worthwhile to greatly intensify efforts in the future for closing the Th/ 233 U fuel cycle. HTGR's are particularly promising for economic application. However, further R and D activites should not be solely focussed on this reactor type alone. Light and heavy-water moderated reactors, as well as even fast breeders later on, may just as well take advantage of a demonstrated thorium fuel cycle. A summary is presented of the state-of-the-art of Th/ 233 U-recycling technology and the efforts still necessary to demonstrate this technology all the way through to its industrial application

  9. Steam turbine cycle

    International Nuclear Information System (INIS)

    Okuzumi, Naoaki.

    1994-01-01

    In a steam turbine cycle, steams exhausted from the turbine are extracted, and they are connected to a steam sucking pipe of a steam injector, and a discharge pipe of the steam injector is connected to an inlet of a water turbine. High pressure discharge water is obtained from low pressure steams by utilizing a pressurizing performance of the steam injector and the water turbine is rotated by the high pressure water to generate electric power. This recover and reutilize discharged heat of the steam turbine effectively, thereby enabling to improve heat efficiency of the steam turbine cycle. (T.M.)

  10. Life Cycle Environmental Management

    DEFF Research Database (Denmark)

    Pedersen, Claus Stig; Jørgensen, Jørgen; Pedersen, Morten Als

    1996-01-01

    A precondition for environmentally conscious management is the awareness of the environmental impact potentials created by an industrial company. There is an obvious need for management tools to support the implementation of relevant environmental criteria into the industrial decision making...... processes. The discipline of life cycle environmental management (LCEM) focuses on the incorporation of environmental criteria from the life cycles of products and other company activities into the company management processes. This paper introduces the concept of LCEM as an important element...... of the complete set of environmental objects in an industrial manufacturing company....

  11. Carbon cycle makeover

    DEFF Research Database (Denmark)

    Canfield, Donald Eugene; Kump, Lee R.

    2013-01-01

    remaining in sediments after respiration leave a residual of oxygen in the atmosphere. The source of oxygen to the atmosphere represented by organic matter burial is balanced by oxygen sinks associated with rock weathering and chemical reaction with volcanic gases. This is the long-term carbon and oxygen...... geochemical cycle. But Earth is an old planet, and oxygen levels have changed through time (2). On page 540 of this issue, Schrag et al. (3) challenge the most commonly used geochemical approach to assess long-term changes in the coupled oxygen and carbon cycles....

  12. Resurrecting Equilibria Through Cycles

    DEFF Research Database (Denmark)

    Barnett, Richard C.; Bhattacharya, Joydeep; Bunzel, Helle

    equilibria because they asymptotically violate some economic restriction of the model. The literature has always ruled out such paths. This paper studies a pure-exchange monetary overlapping generations economy in which real balances cycle forever between momentary equilibrium points. The novelty is to show...... that segments of the offer curve that have been previously ignored, can in fact be used to produce asymptotically valid cyclical paths. Indeed, a cycle can bestow dynamic validity on momentary equilibrium points that had erstwhile been classified as dynamically invalid....

  13. 24-month fuel cycles

    International Nuclear Information System (INIS)

    Rosenstein, R.G.; Sipes, D.E.; Beall, R.H.; Donovan, E.J.

    1986-01-01

    Twenty-four month reload cycles can potentially lessen total power generation costs. While 24-month cores increase purchased fuel costs, the longer cycles reduce the number of refueling outages and thus enhance plant availability; men-rem exposure to site personnel and other costs associated with reload core design and licensing are also reduced. At dual unit sites an operational advantage can be realized by refueling each plant alternately on a 1-year offset basis. This results in a single outage per site per year which can be scheduled for off-peak periods or when replacement power costs are low

  14. Global water cycle

    Science.gov (United States)

    Robertson, Franklin; Goodman, Steven J.; Christy, John R.; Fitzjarrald, Daniel E.; Chou, Shi-Hung; Crosson, William; Wang, Shouping; Ramirez, Jorge

    1993-01-01

    This research is the MSFC component of a joint MSFC/Pennsylvania State University Eos Interdisciplinary Investigation on the global water cycle extension across the earth sciences. The primary long-term objective of this investigation is to determine the scope and interactions of the global water cycle with all components of the Earth system and to understand how it stimulates and regulates change on both global and regional scales. Significant accomplishments in the past year are presented and include the following: (1) water vapor variability; (2) multi-phase water analysis; (3) global modeling; and (4) optimal precipitation and stream flow analysis and hydrologic processes.

  15. Will business cycles in the euro area converge? A critical survey of empirical research

    NARCIS (Netherlands)

    de Haan, J.; Inklaar, R.; Jong-A-Pin, R.

    This survey of business cycle synchronization in the European monetary union focuses on two issues: have business cycles become more similar, and which factors drive business cycle synchronization. We conclude that business cycles in the euro area have gone through periods of both convergence and

  16. Cell cycle control by components of cell anchorage

    OpenAIRE

    Gad, Annica

    2005-01-01

    Extracellular factors, such as growth factors and cell anchorage to the extracellular matrix, control when and where cells may proliferate. This control is abolished when a normal cell transforms into a tumour cell. The control of cell proliferation by cell anchorage was elusive and less well studied than the control by growth factors. Therefore, we aimed to clarify at what points in the cell cycle and through which molecular mechanisms cell anchorage controls cell cycle pro...

  17. Expression and localization of insulin-like growth factor system in corpus luteum during different stages of estrous cycle in water buffaloes (Bubalus bubalis) and the effect of insulin-like growth factor I on production of vascular endothelial growth factor and progesterone in luteal cells cultured in vitro.

    Science.gov (United States)

    Uniyal, S; Panda, R P; Chouhan, V S; Yadav, V P; Hyder, I; Dangi, S S; Gupta, M; Khan, F A; Sharma, G T; Bag, S; Sarkar, M

    2015-01-01

    This study investigated the expression and localization of insulin-like growth factor (IGF) system at different stages of buffalo CL and the role of IGF-I in stimulating vascular endothelial growth factor (VEGF) and progesterone (P4) production in cultured luteal cells. The mRNA expression of IGF system, VEGF, steroidogenic acute regulatory protein, P450scc, and hydroxysteroid dehydrogenase (HSD) was investigated by quantitative real-time polymerase chain reaction (PCR). Protein expression of IGF was demonstrated by Western blot and localization by immunohistochemistry. Progesterone and VEGF production was assayed using RIA and ELISA. A relatively high mRNA expression of IGF-I and IGF-II in early, mid- and late luteal phases with immunoreactivity mostly restricted to cytoplasm of large luteal cells indicates their autocrine role, whereas very weak immunoreactivity in endothelial cells during the mid-luteal phase indicates their paracrine role. Insulin-like growth factor receptors, IGF-IR and IGF-IIR, were restricted to large luteal cells with high mRNA and protein expressions in the mid-luteal phase. The significantly higher expression of insulin-like growth factor binding protein (IGFBP)-1, -3, -5, and -6 in the early or mid-luteal phase suggested their stimulatory role, whereas that of IGFBP-2 and -4 in mid-, late, and regressive luteal stages implied their inhibitory role. The mRNA expressions of key steroidogenic factors and VEGF were significantly higher (P production (P production of VEGF in luteal cells and steroid synthesis through the production of key steroidogenic factors. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Menstrual cycle pattern and fertility

    DEFF Research Database (Denmark)

    Kolstad, Henrik A.; Bonde, Jens Peter; Hjøllund, Niels Henrik

    1999-01-01

    To characterize how the menstrual cycle pattern relates to fertility regardless of potential biases caused by inappropriate coital timing during the menstrual cycle or early embryonal loss.......To characterize how the menstrual cycle pattern relates to fertility regardless of potential biases caused by inappropriate coital timing during the menstrual cycle or early embryonal loss....

  19. Entrepreneurship and the business cycle

    NARCIS (Netherlands)

    Koellinger, Philipp D.; Thurik, A. Roy

    2012-01-01

    We find new empirical regularities in the business cycle in a cross-country panel of 22 OECD countries for the period 1972 to 2007; entrepreneurship Granger-causes the cycles of the world economy. Furthermore, the entrepreneurial cycle is positively affected by the national unemployment cycle. We

  20. World nuclear fuel cycle

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    A coloured pull-out wall chart is presented showing the fuel cycle interests of the world. Place names are marked and symbols are used to indicate regions associated with uranium or thorium deposits, mining, milling, enrichment, reprocessing and fabrication. (UK)

  1. Deuterium in atmospheric cycle

    International Nuclear Information System (INIS)

    Pontikis, M.C.

    Interest of the study concerning the deuterium content variation (HDO) in the atmospheric water. Standards and measurement methods. Molecule HDO cycle in the atmospheric water. Application to the study of hail-generating cumulus-nimbus and of the mantle of snow [fr

  2. Nuclear fuel cycle

    International Nuclear Information System (INIS)

    1993-01-01

    Status of different nuclear fuel cycle phases in 1992 is discussed including the following issues: uranium exploration, resources, supply and demand, production, market prices, conversion, enrichment; reactor fuel technology; spent fuel management, as well as trends of these phases development up to the year 2010. 10 refs, 11 figs, 15 tabs

  3. Life Cycle Inventory Analysis

    DEFF Research Database (Denmark)

    Bjørn, Anders; Moltesen, Andreas; Laurent, Alexis

    2018-01-01

    of different sources. The output is a compiled inventory of elementary flows that is used as basis of the subsequent life cycle impact assessment phase. This chapter teaches how to carry out this task through six steps: (1) identifying processes for the LCI model of the product system; (2) planning...

  4. Life Cycle Collection Management

    Directory of Open Access Journals (Sweden)

    Helen Shenton

    2003-09-01

    Full Text Available Life cycle collection management is a way of taking a long-term approach to the responsible stewardship of the British Library's collections and is one of the Library's strategic strands. It defines the different stages in a collection item's existence over time. These stages range from selection and acquisitions processing, cataloguing and press marking, through to preventive conservation, storage and retrieval. Life cycle collection management seeks to identify the costs of each stage in order to show the economic interdependencies between the phases over time. It thereby aims to demonstrate the long-term consequences of what the library takes into its collections, by making explicit the financial and other implications of decisions made at the beginning of the life cycle for the next 100 plus years. This paper describes the work over the past year at the British Library on this complex and complicated subject. It presents the emerging findings and suggests how it can be used for practical reasons (by individual curators and selectors and for economic, governance and political purposes. The paper describes the next steps in the project, for example, on a predictive data model. The British Library is seeking to benchmark itself against comparable organisations in this area. It intends to work with others on specific comparison for example, of life cycle costing of electronic and paper journals, as a prelude to eliding digital and 'traditional' formats.

  5. Boundedly rational credit cycles

    OpenAIRE

    Sáez, María

    1996-01-01

    We propose an evolutionary model of a credit market. We show that the economy exhibits credit cycles. The model predicts dynamics which are consistent with some evidence about the Great Depression. Real shocks trigger episodes of credit--crunch which are observed in the process of adjustment towards the post shock equilibrium.

  6. 90-Day Cycle Handbook

    Science.gov (United States)

    Park, Sandra; Takahashi, Sola

    2013-01-01

    90-Day Cycles are a disciplined and structured form of inquiry designed to produce and test knowledge syntheses, prototyped processes, or products in support of improvement work. With any type of activity, organizations inevitably encounter roadblocks to improving performance and outcomes. These barriers might include intractable problems at…

  7. Mosquito Life Cycle

    Science.gov (United States)

    Knowing the stages of the mosquito's life will help you prevent mosquitoes around your home and help you choose the right pesticides for your needs, if you decide to use them. All mosquito species go through four distinct stages during their live cycle.

  8. Reasoning with Causal Cycles

    Science.gov (United States)

    Rehder, Bob

    2017-01-01

    This article assesses how people reason with categories whose features are related in causal cycles. Whereas models based on causal graphical models (CGMs) have enjoyed success modeling category-based judgments as well as a number of other cognitive phenomena, CGMs are only able to represent causal structures that are acyclic. A number of new…

  9. WLTP Random Cycle Generator

    NARCIS (Netherlands)

    Kooijman, D.G.; Balau, A.E.; Wilkins, S.; Ligterink, N.; Cuelenaere, R.

    2015-01-01

    European light duty vehicle emission legislation is gradually shifting the focus from test procedures with merely static test cycles, towards procedures including Real Driving Emissions (RDE), as they are a mean to achieve the European (NOx) emission reduction target. Hence a RDE trip must represent

  10. WLTP random cycle generator

    NARCIS (Netherlands)

    Kooijman, D.G.; Balau, A.E.; Wilkins, S.; Ligterink, N.; Cuelenaere, R.

    2015-01-01

    European light duty vehicle emission legislation is gradually shifting the focus from test procedures with merely static test cycles, towards procedures including Real Driving Emissions (RDE), as they are a mean to achieve the European (NOx) emission reduction target. Hence a RDE trip must represent

  11. Combined-cycle plants

    International Nuclear Information System (INIS)

    Valenti, M.

    1991-01-01

    This paper reports that as tougher emissions standards take hold throughout the industrialized world, manufacturers such as GE, Siemens, Foster Wheeler, and Asea Brown Boveri are designing advanced combined-cycle equipment that offers improved environmental performance without sacrificing power efficiency

  12. ITER fuel cycle

    International Nuclear Information System (INIS)

    Leger, D.; Dinner, P.; Yoshida, H.

    1991-01-01

    Resulting from the Conceptual Design Activities (1988-1990) by the parties involved in the International Thermonuclear Experimental Reactor (ITER) project, this document summarizes the design requirements and the Conceptual Design Descriptions for each of the principal subsystems and design options of the ITER Fuel Cycle conceptual design. The ITER Fuel Cycle system provides for the handling of all tritiated water and gas mixtures on ITER. The system is subdivided into subsystems for fuelling, primary (torus) vacuum pumping, fuel processing, blanket tritium recovery, and common processes (including isotopic separation, fuel management and storage, and processes for detritiation of solid, liquid, and gaseous wastes). After an introduction describing system function and conceptual design procedure, a summary of the design is presented including a discussion of scope and main parameters, and the fuel design options for fuelling, plasma chamber vacuum pumping, fuel cleanup, blanket tritium recovery, and auxiliary and common processes. Design requirements are defined and design descriptions are given for the various subsystems (fuelling, plasma vacuum pumping, fuel cleanup, blanket tritium recovery, and auxiliary/common processes). The document ends with sections on fuel cycle design integration, fuel cycle building layout, safety considerations, a summary of the research and development programme, costing, and conclusions. Refs, figs and tabs

  13. Understanding Solar Cycle Variability

    Energy Technology Data Exchange (ETDEWEB)

    Cameron, R. H.; Schüssler, M., E-mail: cameron@mps.mpg.de [Max-Planck-Institut für Sonnensystemforschung, Justus-von-Liebig-Weg 3, D-37077 Göttingen (Germany)

    2017-07-10

    The level of solar magnetic activity, as exemplified by the number of sunspots and by energetic events in the corona, varies on a wide range of timescales. Most prominent is the 11-year solar cycle, which is significantly modulated on longer timescales. Drawing from dynamo theory, together with the empirical results of past solar activity and similar phenomena for solar-like stars, we show that the variability of the solar cycle can be essentially understood in terms of a weakly nonlinear limit cycle affected by random noise. In contrast to ad hoc “toy models” for the solar cycle, this leads to a generic normal-form model, whose parameters are all constrained by observations. The model reproduces the characteristics of the variable solar activity on timescales between decades and millennia, including the occurrence and statistics of extended periods of very low activity (grand minima). Comparison with results obtained with a Babcock–Leighton-type dynamo model confirm the validity of the normal-mode approach.

  14. The plutonium fuel cycles

    International Nuclear Information System (INIS)

    Pigford, T.H.; Ang, K.P.

    1975-01-01

    The quantities of plutonium and other fuel actinides have been calculated for equilibrium fuel cycles for 1000-MW water reactors fueled with slightly enriched uranium, water reactors fueled with plutonium and natural uranium, fast-breder reactors, gas-cooled reactors fueled with thorium and highly enriched uranium, and gas-cooled reactors fueled with thorium, plutonium and recycled uranium. The radioactivity quantities of plutonium, americium and curium processed yearly in these fuel cycles are greatest for the water reactors fueled with natural uranium and recycled plutonium. The total amount of actinides processed is calculated for the predicted future growth of the U.S. nuclear power industry. For the same total installed nuclear power capacity, the introduction of the plutonium breeder has little effect upon the total amount of plutonium in this century. The estimated amount of plutonium in the low-level process wastes in the plutonium fuel cycles is comparable to the amount of plutonium in the high-level fission product wastes. The amount of plutonium processed in the nuclear fuel cycles can be considerably reduced by using gas-cooled reactors to consume plutonium produced in uranium-fueled water reactors. These, and other reactors dedicated for plutonium utilization, could be co-located with facilities for fuel reprocessing ad fuel fabrication to eliminate the off-site transport of separated plutonium. (author)

  15. Fuel cycle oriented approach

    International Nuclear Information System (INIS)

    Petit, A.

    1987-01-01

    The term fuel cycle oriented approach is currently used to designate two quite different things: the attempt to consider all or part of a national fuel cycle as one material balance area (MBA) or to consider individual MBAs existing in a state while designing a unique safeguards approach for each and applying the principle of nondiscrimination to fuel cycles as a whole, rather than to individual facilities. The merits of such an approach are acceptability by the industry and comparison with the contemplated establishment of long-term criteria. The following points concern the acceptability by the industry: (1) The main interest of the industry is to keep an open international market and therefore, to have effective and efficient safeguards. (2) The main concerns of the industry regarding international safeguards are economic burden, intrusiveness, and discrimination. Answers to these legitimate concerns, which retain the benefits of a fuel cycle oriented approach, are needed. More specifically, the problem of reimbursing the operator the costs that he has incurred for the safeguards must be considered

  16. The Geologic Nitrogen Cycle

    Science.gov (United States)

    Johnson, B. W.; Goldblatt, C.

    2013-12-01

    N2 is the dominant gas in Earth's atmosphere, and has been so through the majority of the planet's history. Originally thought to only be cycled in significant amounts through the biosphere, it is becoming increasingly clear that a large degree of geologic cycling can occur as well. N is present in crustal rocks at 10s to 100s of ppm and in the mantle at 1s to perhaps 10s of ppm. In light of new data, we present an Earth-system perspective of the modern N cycle, an updated N budget for the silicate Earth, and venture to explain the evolution of the N cycle over time. In an fashion similar to C, N has a fast, biologically mediated cycle and a slower cycle driven by plate tectonics. Bacteria fix N2 from the atmosphere into bioavailable forms. N is then cycled through the food chain, either by direct consumption of N-fixing bacteria, as NH4+ (the primary waste form), or NO3- (the most common inorganic species in the modern ocean). Some organic material settles as sediment on the ocean floor. In anoxic sediments, NH4+ dominates; due to similar ionic radii, it can readily substitute for K+ in mineral lattices, both in sedimentary rocks and in oceanic lithosphere. Once it enters a subduction zone, N may either be volatilized and returned to the atmosphere at arc volcanoes as N2 or N2O, sequestered into intrusive igneous rocks (as NH4+?), or subducted deep into the mantle, likely as NH4+. Mounting evidence indicates that a significant amount of N may be sequestered into the solid Earth, where it may remain for long periods (100s m.y.) before being returned to the atmosphere/biosphere by volcanism or weathering. The magnitude fluxes into the solid Earth and size of geologic N reservoirs are poorly constrained. The size of the N reservoirs contained in the solid Earth directly affects the evolution of Earth's atmosphere. It is possible that N now sequestered in the solid Earth was once in the atmosphere, which would have resulted in a higher atmospheric pressure, and

  17. The nuclear fuel cycle light and shadow

    International Nuclear Information System (INIS)

    Giraud, A.

    1977-01-01

    The nuclear fuel cycle industry has a far reaching effect on future world energy developments. The growth in turnover of this industry follows a known patterm; by 1985 this turnover will have reached a figure of 2 billion dollars. Furthermore, the fuel cycle plays a determining role in ensuring the physical continuity of energy supplies for countries already engaged in the nuclear domain. Finally, the development of this industry is subject to economic and political constraints which imply the availability of raw materials, technological know-how, and production facilities. Various factors which could have an adverse influence on the cycle: technical, economic, or financial difficulties, environmental impact, nuclear safety, theft or diversion of nuclear materials, nuclear weapon, proliferation risks, are described, and the interaction between the development of the cycle, energy independance, and the fulfillment of nuclear energy programs is emphasized. It is concluded that the nuclear fuel cycle industry is confronted with difficulties due to its extremely rapid growth rate (doubling every 5 years); it is a long time since such a growth rate has been experienced by any heavy industry. The task which lays before us is difficult, but the fruit is worth the toil, as it is the fuel cycle which will govern the growth of the nuclear industry [fr

  18. Internal cycle modeling and environmental assessment of multiple cycle consumer products

    International Nuclear Information System (INIS)

    Tsiliyannis, C.A.

    2012-01-01

    Highlights: ► Dynamic flow models are presented for remanufactured, reused or recycled products. ► Early loss and stochastic return are included for fast and slow cycling products. ► The reuse-to-input flow ratio (Internal Cycle Factor, ICF) is determined. ► The cycle rate, which is increasing with the ICF, monitors eco-performance. ► Early internal cycle losses diminish the ICF, the cycle rate and performance. - Abstract: Dynamic annual flow models incorporating consumer discard and usage loss and featuring deterministic and stochastic end-of-cycle (EOC) return by the consumer are developed for reused or remanufactured products (multiple cycle products, MCPs), including fast and slow cycling, short and long-lived products. It is shown that internal flows (reuse and overall consumption) increase proportionally to the dimensionless internal cycle factor (ICF) which is related to environmental impact reduction factors. The combined reuse/recycle (or cycle) rate is shown capable for shortcut, albeit effective, monitoring of environmental performance in terms of waste production, virgin material extraction and manufacturing impacts of all MCPs, a task, which physical variables (lifetime, cycling frequency, mean or total number of return trips) and conventional rates, via which environmental policy has been officially implemented (e.g. recycling rate) cannot accomplish. The cycle rate is shown to be an increasing (hyperbolic) function of ICF. The impact of the stochastic EOC return characteristics on total reuse and consumption flows, as well as on eco-performance, is assessed: symmetric EOC return has a small, positive effect on performance compared to deterministic, while early shifted EOC return is more beneficial. In order to be efficient, environmental policy should set higher minimum reuse targets for higher trippage MCPs. The results may serve for monitoring, flow accounting and comparative eco-assessment of MCPs. They may be useful in identifying

  19. Evaluation and optimization of LWR fuel cycles

    International Nuclear Information System (INIS)

    Akbas, T.; Zabunoglu, O.; Tombakoglu, M.

    2001-01-01

    There are several options in the back-end of the nuclear fuel cycle. Discharge burn-up, length of interim storage period, choice of direct disposal or recycling and method of reprocessing in case of recycling affect the options and determine/define the fuel cycle scenarios. These options have been evaluated in viewpoint of some tangible (fuel cycle cost, natural uranium requirement, decay heat of high level waste, radiological ingestion and inhalation hazards) and intangible factors (technological feasibility, nonproliferation aspect, etc.). Neutronic parameters are calculated using versatile fuel depletion code ORIGEN2.1. A program is developed for calculation of cost related parameters. Analytical hierarchy process is used to transform the intangible factors into the tangible ones. Then all these tangible and intangible factors are incorporated into a form that is suitable for goal programming, which is a linear optimization technique and used to determine the optimal option among alternatives. According to the specified objective function and constraints, the optimal fuel cycle scenario is determined using GPSYS (a linear programming software) as a goal programming tool. In addition, a sensitivity analysis is performed for some selected important parameters

  20. Violence as a Vicious Cycle

    Directory of Open Access Journals (Sweden)

    Huseyin Gulec

    2012-03-01

    Full Text Available Since the conclusion that the violence as a behavior is not (cannot be determined within an absolute genetic determinism has been reached for long years, environmental factors are increasingly examined. We witness that human behavior in society can easily convert into coping with stressful events with violence. Individual or social violence as a behavior has a similar pattern with violence committed in primitive society and by children. After a brief review of violence, its description, etiological theories and types, this article majorly focuses on children and their early and late response to violence. The purpose here is to draw attention to the individuals who were previously exposed to violence (either directly or indirectly resort to violence, perpetuating a vicious cycle.

  1. Climate and the Carbon Cycle

    Science.gov (United States)

    Manley, Jim

    2017-04-01

    Climate and the Carbon Cycle EOS3a Science in tomorrow's classroom Students, like too much of the American public, are largely unaware or apathetic to the changes in world climate and the impact that these changes have for life on Earth. A study conducted by Michigan State University and published in 2011 by Science Daily titled 'What carbon cycle? College students lack scientific literacy, study finds'. This study relates how 'most college students in the United States do not grasp the scientific basis of the carbon cycle - an essential skill in understanding the causes and consequences of climate change.' The study authors call for a new approach to teaching about climate. What if teachers better understood vital components of Earth's climate system and were able to impart his understanding to their students? What if students based their responses to the information taught not on emotion, but on a deeper understanding of the forces driving climate change, their analysis of the scientific evidence and in the context of earth system science? As a Middle School science teacher, I have been given the opportunity to use a new curriculum within TERC's EarthLabs collection, Climate and the Carbon Cycle, to awaken those brains and assist my students in making personal lifestyle choices based on what they had learned. In addition, with support from TERC and The University of Texas Institute for Geophysics I joined others to begin training other teachers on how to implement this curriculum in their classrooms to expose their students to our changing climate. Through my poster, I will give you (1) a glimpse into the challenges faced by today's science teachers in communicating the complicated, but ever-deepening understanding of the linkages between natural and human-driven factors on climate; (2) introduce you to a new module in the EarthLabs curriculum designed to expose teachers and students to global scientific climate data and instrumentation; and (3) illustrate how

  2. Riding the cycle

    Energy Technology Data Exchange (ETDEWEB)

    Webster, G. [Canadian Association of Petroleum Producers, Calgary, AB (Canada)

    2001-07-01

    The current state of the Canadian oil and natural gas industry is reviewed as part of a discussion of economic cycles focusing in particular on the most recent cycle and the impact it has had on the industry. The review of the state of the industry includes discussion of production, exports, commodity prices, the stimulating effect of price increases on the number of oil and natural gas wells drilled, drilling rig operating days. Also discussed are the effect of foreign exchange rates, capital spending, industry financial performance in terms of return on capital employed, the impact of oil and gas prices on Alberta provincial revenues, estimates of Canada's ultimate crude oil and natural gas resources potential, pipelines and pipeline proposals for northern gas, and projection of crude oil and natural gas production in Canada to 2010.

  3. Fuel cycle services

    International Nuclear Information System (INIS)

    Gruber, Gerhard J.

    1990-01-01

    TRIGA reactor operators are increasingly concerned about the back end of their Fuel Cycle due to a new environmental policy in the USA. The question how to close the Fuel Cycle will have to be answered by all operators sooner or later. Reprocessing of the TRIGA fuel elements is not available. Only long term storage and final disposal can be considered. But for such a storage or disposal a special treatment of the fuel elements and of course a final depository is necessary. NUKEM plans to undertake efforts to assist the TRIGA operators in this area. For that reason we need to know your special needs for today and tomorrow - so that potential processors can consider whether to offer these services on the market. (orig.)

  4. Riding the cycle

    International Nuclear Information System (INIS)

    Webster, G.

    2001-01-01

    The current state of the Canadian oil and natural gas industry is reviewed as part of a discussion of economic cycles focusing in particular on the most recent cycle and the impact it has had on the industry. The review of the state of the industry includes discussion of production, exports, commodity prices, the stimulating effect of price increases on the number of oil and natural gas wells drilled, drilling rig operating days. Also discussed are the effect of foreign exchange rates, capital spending, industry financial performance in terms of return on capital employed, the impact of oil and gas prices on Alberta provincial revenues, estimates of Canada's ultimate crude oil and natural gas resources potential, pipelines and pipeline proposals for northern gas, and projection of crude oil and natural gas production in Canada to 2010

  5. Assessing Cycling Participation in Australia

    Directory of Open Access Journals (Sweden)

    Chris Rissel

    2013-01-01

    Full Text Available Planning and evaluating cycling programs at a national or state level requires accurate measures of cycling participation. However, recent reports of cycling participation have produced very different estimates. This paper examines the reported rates of cycling in five recent population surveys of cycling. Three surveys (one national and two from Sydney asking respondents when they last rode a bicycle generated cycling participation (cycled in the past year estimates of 29.7%, 34.1% and 28.9%. Two other national surveys which asked participants to recall (unprompted any physical activity done for exercise, recreation or sport in the previous 12 months, estimated cycling in the past year as 11.1% and 6.5%. While unprompted recall of cycling as a type of physical activity generates lower estimates of cycling participation than specific recall questions, both assessment approaches produced similar patterns of cycling by age and sex with both approaches indicating fewer women and older adults cycling. The different question styles most likely explain the substantial discrepancies between the estimates of cycling participation. Some differences are to be expected due to sampling variability, question differences, and regional variation in cycling.

  6. Stirling cycle engine

    Science.gov (United States)

    Lundholm, Gunnar

    1983-01-01

    In a Stirling cycle engine having a plurality of working gas charges separated by pistons reciprocating in cylinders, the total gas content is minimized and the mean pressure equalization among the serial cylinders is improved by using two piston rings axially spaced at least as much as the piston stroke and by providing a duct in the cylinder wall opening in the space between the two piston rings and leading to a source of minimum or maximum working gas pressure.

  7. The nuclear fuel cycle

    International Nuclear Information System (INIS)

    Anon.

    1975-01-01

    The papers presented at the International Conference on The Nuclear Fuel Cycle, held at Stockholm, 28 to 31 October 1975, are reviewed. The meeting, organised by the U.S. Atomic Industrial Forum, and the Swedish Nuclear Forum, was concerned more particularly with economic, political, social and commercial aspects than with tecnology. The papers discussed were considered under the subject heading of current status, uranium resources, enrichment, and reprocessing. (U.K.)

  8. Nuclear fuel cycle

    Energy Technology Data Exchange (ETDEWEB)

    1975-12-01

    The papers presented at the International Conference on The Nuclear Fuel Cycle, held at Stockholm, 28 to 31 October 1975, are reviewed. The meeting, organised by the U.S. Atomic Industrial Forum, and the Swedish Nuclear Forum, was concerned more particularly with economic, political, social and commercial aspects than with tecnology. The papers discussed were considered under the subject heading of current status, uranium resources, enrichment, and reprocessing.

  9. Alternative nuclear fuel cycles

    International Nuclear Information System (INIS)

    Till, C.E.

    1979-01-01

    This diffuse subject involves value judgments that are political as well as technical, and is best understood in that context. The four questions raised here, however, are mostly from the technical viewpoints: (1) what are alternative nuclear fuel cycles; (2) what generalizations are possible about their characteristics; (3) what are the major practical considerations; and (4) what is the present situation and what can be said about the outlook for the future

  10. HCl removal using cycled carbide slag from calcium looping cycles

    International Nuclear Information System (INIS)

    Xie, Xin; Li, Yingjie; Wang, Wenjing; Shi, Lei

    2014-01-01

    Highlights: • Cycled carbide slag from calcium looping cycles is used to remove HCl. • The optimum temperature for HCl removal of cycled carbide slag is 700 °C. • The presence of CO 2 restrains HCl removal of cycled carbide slag. • CO 2 capture conditions have important effects on HCl removal of cycled carbide slag. • HCl removal capacity of carbide slag drops with cycle number rising from 1 to 50. - Abstract: The carbide slag is an industrial waste from chlor-alkali plants, which can be used to capture CO 2 in the calcium looping cycles, i.e. carbonation/calcination cycles. In this work, the cycled carbide slag from the calcium looping cycles for CO 2 capture was proposed to remove HCl in the flue gas from the biomass-fired and RDFs-fired boilers. The effects of chlorination temperature, HCl concentration, particle size, presence of CO 2 , presence of O 2 , cycle number and CO 2 capture conditions in calcium looping cycles on the HCl removal behavior of the carbide slag experienced carbonation/calcination cycles were investigated in a triple fixed-bed reactor. The chlorination product of the cycled carbide slag from the calcium looping after absorbing HCl is not CaCl 2 but CaClOH. The optimum temperature for HCl removal of the cycled carbide slag from the carbonation/calcination cycles is 700 °C. The chlorination conversion of the cycled carbide slag increases with increasing the HCl concentration. The cycled carbide slag with larger particle size exhibits a lower chlorination conversion. The presence of CO 2 decreases the chlorination conversions of the cycled carbide slag and the presence of O 2 has a trifling impact. The chlorination conversion of the carbide slag experienced 1 carbonation/calcination cycle is higher than that of the uncycled calcined sorbent. As the number of carbonation/calcination cycles increases from 1 to 50, the chlorination conversion of carbide slag drops gradually. The high calcination temperature and high CO 2

  11. The urea cycle disorders.

    Science.gov (United States)

    Helman, Guy; Pacheco-Colón, Ileana; Gropman, Andrea L

    2014-07-01

    The urea cycle is the primary nitrogen-disposal pathway in humans. It requires the coordinated function of six enzymes and two mitochondrial transporters to catalyze the conversion of a molecule of ammonia, the α-nitrogen of aspartate, and bicarbonate into urea. Whereas ammonia is toxic, urea is relatively inert, soluble in water, and readily excreted by the kidney in the urine. Accumulation of ammonia and other toxic intermediates of the cycle lead to predominantly neurologic sequelae. The disorders may present at any age from the neonatal period to adulthood, with the more severely affected patients presenting earlier in life. Patients are at risk for metabolic decompensation throughout life, often triggered by illness, fasting, surgery and postoperative states, peripartum, stress, and increased exogenous protein load. Here the authors address neurologic presentations of ornithine transcarbamylase deficiency in detail, the most common of the urea cycle disorders, neuropathology, neurophysiology, and our studies in neuroimaging. Special attention to late-onset presentations is given. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  12. International Business Cycle

    Directory of Open Access Journals (Sweden)

    Marek Lubiński

    2007-04-01

    Full Text Available Prime stylized facts of international business cycle theory refer to positive correlation in the cyclical components of important macroeconomic variables across countries. However a number of indicators of business cycle synchronization do not point to clear trends. It can be ascribed to the fact that different forces influence level of business cycle correlation. When investigating into the forces behind the commonness in aggregate fluctuations economic research seems to have pointed in two directions. One strand of the literature examines the idea of common exogenous shocks that affect economies simultaneously. In addition to that economic interdependencies such as trade in goods and services or capital account transactions may serve as the channels through which disturbances spill over across countries.The observed degree of output co movement reflects both the nature of the shocks that have occurred and the degree of economic interdependence. In the periods when common shocks prevail level of synchronization is usually higher than in times of transmission dominance.

  13. Closing the fuel cycle

    International Nuclear Information System (INIS)

    Aycoberry, C.; Rougeau, J.P.

    1987-01-01

    The progressive implementation of some key nuclear fuel cycle capecities in a country corresponds to a strategy for the acquisition of an independant energy source, France, Japan, and some European countries are engaged in such strategic programs. In France, COGEMA, the nuclear fuel company, has now completed the industrial demonstration of the closed fuel cycle. Its experience covers every step of the front-end and of the back-end: transportation of spent fuels, storage, reprocessing, wastes conditioning. The La Hague reprocessing plant smooth operation, as well as the large investment program under active progress can testify of full mastering of this industry. Together with other French and European companies, COGEMA is engaged in the recycling industry, both for uranium through conversion of uranyl nitrate for its further reeichment, and for plutonium through MOX fuel fabrication. Reprocessing and recycling offer the optimum solution for a complete, economic, safe and future-oriented fuel cycle, hence contributing to the necessary development of nuclear energy. (author)

  14. The nuclear fuel cycle, Economical, environmental and social aspects

    International Nuclear Information System (INIS)

    2002-01-01

    The nuclear energy part in the durable development depends of many factors, bound to the fuel cycle. This document describes the developments and the tendencies in the fuel cycle domain, susceptible of improve the competitiveness and the durability of the nuclear energy systems at moderate and long-dated. Evaluation criteria and indicators illustrate the analysis. (A.L.B.)

  15. Nonhepatic hyperammonemic encephalopathy due to undiagnosed urea cycle disorder

    OpenAIRE

    Mahmood, Tashfeen; Nugent, Kenneth

    2015-01-01

    Ornithine transcarbamoylase deficiency is the most common inherited urea cycle disorder. In adults, its phenotypes are diverse. In asymptomatic patients with late presentations, symptom onset is often associated with a precipitating factor. We present a case of a woman with urea cycle disorder diagnosed after an acute peptic ulcer bleed and fasting.

  16. Nonhepatic hyperammonemic encephalopathy due to undiagnosed urea cycle disorder.

    Science.gov (United States)

    Mahmood, Tashfeen; Nugent, Kenneth

    2015-07-01

    Ornithine transcarbamoylase deficiency is the most common inherited urea cycle disorder. In adults, its phenotypes are diverse. In asymptomatic patients with late presentations, symptom onset is often associated with a precipitating factor. We present a case of a woman with urea cycle disorder diagnosed after an acute peptic ulcer bleed and fasting.

  17. Conditional political budget cycles: a review of recent evidence

    NARCIS (Netherlands)

    Haan, de J.; Klomp, J.G.

    2013-01-01

    Until recently, most research on political budget cycles was based on the (often implicit) presumption that these cycles do not differ across countries. However, more recent studies focus on heterogeneity. This paper surveys studies examining the factors conditioning the occurrence and strength of

  18. A Numerical Approach to Long Cycles in Graphs and Digraphs

    Czech Academy of Sciences Publication Activity Database

    Fiedler, Miroslav

    2001-01-01

    Roč. 235, - (2001), s. 233-236 ISSN 0012-365X R&D Projects: GA ČR GA201/98/0222 Institutional research plan: AV0Z1030915 Keywords : graph * diagraph * cycle * Hamilton cycle Subject RIV: BA - General Mathematics Impact factor: 0.301, year: 2001

  19. EDWARDS' REFERENCE CYCLE FOR INTERNAL AND EXTERNAL COMBUSTION ENGINES

    OpenAIRE

    A. E. Piir

    2014-01-01

    Useful physical regularities of a reversible thermodynamic cycle for heat engines have been established in the paper. The engines are using fuel combustion products as a heat source, and the environment - as a heat sink that surpasses Carnot cycle according to efficiency factor.

  20. Business cycle indexes : does a heap of data help?

    NARCIS (Netherlands)

    Inklaar, Robert; Jacobs, Jan; Romp, Ward

    2003-01-01

    Business cycle indexes are used to get a timely and frequent description of the state of the economy and its likely development in the near future. This paper discusses two methods for constructing business cycle indexes, the traditional NBER method and a recently developed dynamic factor model, and

  1. Historical Business Cycles and Market Integration: Evidence from Comovement

    NARCIS (Netherlands)

    Uebele, Martin

    2009-01-01

    This thesis addresses historical business cycles and market integration in Europe and America in the 19th and 20th centuries. For the analysis of historical business cycles, the widely used methodology of historical national accounting is complemented with a dynamic factor model that allows for

  2. The Menstrual Cycle and Response to Erotic Literature

    Science.gov (United States)

    Abramson, Paul R.; And Others

    1976-01-01

    This study focuses upon the relationship between phase of the menstrual cycle and sexual arousability. Women (N=133) participated in an experiment that induced sexual arousal by means of an erotic story. Independent factors were use of contraceptive pills versus no contraceptive pills and phase of the menstrual cycle. (Author)

  3. Conditional political budget cycles : a review of recent evidence

    NARCIS (Netherlands)

    de Haan, J.; Klomp, J.G.

    2013-01-01

    Until recently, most research on political budget cycles was based on the (often implicit) presumption that these cycles do not differ across countries. However, more recent studies focus on heterogeneity. This paper surveys studies examining the factors conditioning the occurrence and strength of

  4. Thermal Cycling of Uranium Dioxide - Tungsten Cermet Fuel Specimens

    Energy Technology Data Exchange (ETDEWEB)

    Gripshover, P.J.; Peterson, J.H.

    1969-12-08

    In phase I tungsten clad cermet fuel specimens were thermal cycled, to study the effects of fuel loading, fuel particle size, stablized fuel, duplex coatings, and fabrication techniques on dimensional stability during thermal cycling. In phase II the best combination of the factors studies in phase I were combined in one specimen for evaluation.

  5. BUSINESS CYCLES, ELECTORAL CYCLES. TOWARD A THEORETICAL FRAME OF INTERACTION

    Directory of Open Access Journals (Sweden)

    BOGDAN-LUCIAN DOSPINESCU

    2015-06-01

    Full Text Available The idea of cyclical movement of a system: be it political, economic, institutional, is one of the constants of critical thinking. In this sense, there is a natural cyclic movement that cannot be avoided (only amplified or diminished and is connected with the nature of these systems. The economy follows a cyclical movement; a period of growth follows a period of decline, and so on. So does popularity for political parties or leaders. In this paper, I explore the links between the business cycles and electoral cycles. For this purpose, I introduce the concept of electoral perception cycles. My hypothesis is that popularity of political parties and leaders follow a cyclical evolution, both on short and long term. I show how perception cycles can impact the “political business cycle theory”. There is great interest in political science literature for the factors that influence the fluctuations in Presidents’ popularity, especially from United States. However, very little has been said about Romania’s case. I investigate the hypothesis of electoral perception cycles looking at the popularity of former president Traian Basescu, over his two terms. The variable used to measure popularity is favorability, measured in national surveys, done face to face, on representative samplez, of around 1000 subjects. I’ve correlated the fluctuations in favorability over time, with key public events or political decisions taken by Traian Băsescu. The main findings are as follows. Firstly, there are significant short term fluctuations (short term perception cycles and they are correlated with major events on the agenda. I would point the following key moments: 1. The referendum for dismissal of the President in May 2007 – Traian Băsescu’s favorability increased by 7 percentage points; 2. The referendum for unicameral Parliament with 300 MPs in the fall of 2009. Coupled with victory in the presidential election, it lead to an increase of 10 percentage

  6. The Contemporary Carbon Cycle

    Science.gov (United States)

    Houghton, R. A.

    2003-12-01

    The global carbon cycle refers to the exchanges of carbon within and between four major reservoirs: the atmosphere, the oceans, land, and fossil fuels. Carbon may be transferred from one reservoir to another in seconds (e.g., the fixation of atmospheric CO2 into sugar through photosynthesis) or over millennia (e.g., the accumulation of fossil carbon (coal, oil, gas) through deposition and diagenesis of organic matter). This chapter emphasizes the exchanges that are important over years to decades and includes those occurring over the scale of months to a few centuries. The focus will be on the years 1980-2000 but our considerations will broadly include the years ˜1850-2100. Chapter 8.09, deals with longer-term processes that involve rates of carbon exchange that are small on an annual timescale (weathering, vulcanism, sedimentation, and diagenesis).The carbon cycle is important for at least three reasons. First, carbon forms the structure of all life on the planet, making up ˜50% of the dry weight of living things. Second, the cycling of carbon approximates the flows of energy around the Earth, the metabolism of natural, human, and industrial systems. Plants transform radiant energy into chemical energy in the form of sugars, starches, and other forms of organic matter; this energy, whether in living organisms or dead organic matter, supports food chains in natural ecosystems as well as human ecosystems, not the least of which are industrial societies habituated (addicted?) to fossil forms of energy for heating, transportation, and generation of electricity. The increased use of fossil fuels has led to a third reason for interest in the carbon cycle. Carbon, in the form of carbon dioxide (CO2) and methane (CH4), forms two of the most important greenhouse gases. These gases contribute to a natural greenhouse effect that has kept the planet warm enough to evolve and support life (without the greenhouse effect the Earth's average temperature would be -33

  7. Biological phosphorus cycling in dryland regions

    Science.gov (United States)

    Belnap, Jayne; Bunemann, Else; Oberson, Astrid; Frossard, Emmanuel

    2011-01-01

    The relatively few studies done on phosphorus (P) cycling in arid and semiarid lands (drylands) show many factors that distinguish P cycling in drylands from that in more mesic regions. In drylands, most biologically relevant P inputs and losses are from the deposition and loss of dust. Horizontal and vertical redistribution of P is an important process. P is concentrated at the soil surface and thus vulnerable to loss via erosion. High pH and CaCO3 limit P bioavailability, and low rainfall limits microbe and plant ability to free abiotically bound P via exudates, thus making it available for uptake. Many invasive plants are able to access recalcitrant P more effectively than are native plants. As P availability depends on soil moisture and temperature, climate change is expected to have large impacts on P cycling

  8. Nuclear fuel cycle system analysis

    International Nuclear Information System (INIS)

    Ko, W. I.; Kwon, E. H.; Kim, S. G.; Park, B. H.; Song, K. C.; Song, D. Y.; Lee, H. H.; Chang, H. L.; Jeong, C. J.

    2012-04-01

    The nuclear fuel cycle system analysis method has been designed and established for an integrated nuclear fuel cycle system assessment by analyzing various methodologies. The economics, PR(Proliferation Resistance) and environmental impact evaluation of the fuel cycle system were performed using improved DB, and finally the best fuel cycle option which is applicable in Korea was derived. In addition, this research is helped to increase the national credibility and transparency for PR with developing and fulfilling PR enhancement program. The detailed contents of the work are as follows: 1)Establish and improve the DB for nuclear fuel cycle system analysis 2)Development of the analysis model for nuclear fuel cycle 3)Preliminary study for nuclear fuel cycle analysis 4)Development of overall evaluation model of nuclear fuel cycle system 5)Overall evaluation of nuclear fuel cycle system 6)Evaluate the PR for nuclear fuel cycle system and derive the enhancement method 7)Derive and fulfill of nuclear transparency enhancement method The optimum fuel cycle option which is economical and applicable to domestic situation was derived in this research. It would be a basis for establishment of the long-term strategy for nuclear fuel cycle. This work contributes for guaranteeing the technical, economical validity of the optimal fuel cycle option. Deriving and fulfillment of the method for enhancing nuclear transparency will also contribute to renewing the ROK-U.S Atomic Energy Agreement in 2014

  9. Alternative ORC bottoming cycles FOR combined cycle power plants

    International Nuclear Information System (INIS)

    Chacartegui, R.; Sanchez, D.; Munoz, J.M.; Sanchez, T.

    2009-01-01

    In this work, low temperature Organic Rankine Cycles are studied as bottoming cycle in medium and large scale combined cycle power plants. The analysis aims to show the interest of using these alternative cycles with high efficiency heavy duty gas turbines, for example recuperative gas turbines with lower gas turbine exhaust temperatures than in conventional combined cycle gas turbines. The following organic fluids have been considered: R113, R245, isobutene, toluene, cyclohexane and isopentane. Competitive results have been obtained for toluene and cyclohexane ORC combined cycles, with reasonably high global efficiencies. The paper is structured in four main parts. A review of combined cycle and ORC cycle technologies is presented, followed by a thermodynamic analysis of combined cycles with commercial gas turbines and ORC low temperature bottoming cycles. Then, a parametric optimization of an ORC combined cycle plant is performed in order to achieve a better integration between these two technologies. Finally, some economic considerations related to the use of ORC in combined cycles are discussed.

  10. Large-scale fuel cycle centers

    International Nuclear Information System (INIS)

    Smiley, S.H.; Black, K.M.

    1977-01-01

    economic penalties of combined centers. The need for effective fissile material controls on an international scale, and the lack of a technologic requirement for co-location (on a national basis) of fuel cycle facilities, has led to the concept of the multinational fuel cycle facility. However, the establishment of such a facility requires resolution of a number of factors not ordinarily needing consideration. These factors can be broadly characterized in four categories: (1) Adminstrative and Organizational; (2) Economic and Financial; (3) Technical; and (4) Operational. Each of these broad areas has been examined on a preliminary basis for a particular geographic region on behalf of a multinational grouping of organizations. The purpose of this examination has been to determine the feasibility of such a concept and to identify the problems that need to be overcome to assure its ultimate success

  11. LIFE CYCLE OF A WINE BRAND

    Directory of Open Access Journals (Sweden)

    Viktoriia Paziuk

    2015-11-01

    Full Text Available The aim of the work is to determine the life cycle of the wine brand, the development of ways to improve its effectiveness at different stages of the life cycle. Being scientifically informed of the existence of the life cycle of the brand allows modern enterprises to enhance their competitive position in the market and take advantage of the acquired differences in order to attract more attention from consumers. Methods. The study is based on scientific methods of research of economic phenomena: the dialectic, abstract logical (in the exercise of theoretical generalizations to the definition of the concept of «life cycle of the perpetrator of the brand, a scientific abstraction, comparison and ordering (the study of factors influencing the life cycle of the perpetrator of the brand and the factors influencing a choice of products for consumers, statistical and problem-chronological (the study of the requirements of the brand in a changing consumer preferences, logical generalization (in determining the social and ethical functions guilty brand. Results. The stages of the life cycle of the wine brand, which take into account its characteristics and form its social and ethical functions. Describing the requirements for the wine brand in the changing tastes and preferences of consumers. Specification of wine promotion of the brand in an increasingly competitive environment. Preconditions have been set for a new wine brand. The practical significance. The brand always increases the value of the product and its entry into new markets, as well as reduces the time to attract consumers. Possibility to ensure the growth of the brand in a declining market; building market share in a highly competitive environment; marketing innovative products in order to create a new sales strategy. After all, to gain and maintain the popularity of a certain product, one must personalize it with giving associations and a way to provide it with distinctive features. Only

  12. Audit of Major Defense Acquisition Programs Cycle Time

    National Research Council Canada - National Science Library

    Ugone, Mary

    2001-01-01

    ... (GPRA) as indicated in the FY 2000 Annual Report of the Secretary of Defense. Specifically, we assessed whether the process and factors, used to establish the metric goal of MDAP cycle time, were valid...

  13. Europe-wide dampening of population cycles in keystone herbivores

    Czech Academy of Sciences Publication Activity Database

    Cornulier, T.; Yoccoz, N. G.; Bretagnolle, V.; Brommer, J. E.; Butet, A.; Ecke, F.; Elston, D. A.; Framstad, E.; Henttonen, H.; Hornfeldt, B.; Huitu, O.; Imholt, C.; Ims, R. A.; Jacob, J.; Jedrzejewska, B.; Millon, A.; Petty, S. J.; Pietiainen, H.; Tkadlec, Emil; Zub, K.; Lambin, X.

    2013-01-01

    Roč. 340, č. 6128 (2013), s. 63-66 ISSN 0036-8075 Institutional support: RVO:68081766 Keywords : grey -sided vole * density-dependence * lemming cycles Subject RIV: EG - Zoology Impact factor: 31.477, year: 2013

  14. GEOSS Water Cycle Integrator

    Science.gov (United States)

    Koike, Toshio; Lawford, Richard; Cripe, Douglas

    2013-04-01

    It is critically important to recognize and co-manage the fundamental linkages across the water-dependent domains; land use, including deforestation; ecosystem services; and food-, energy- and health-securities. Sharing coordinated, comprehensive and sustained observations and information for sound decision-making is a first step; however, to take full advantage of these opportunities, we need to develop an effective collaboration mechanism for working together across different disciplines, sectors and agencies, and thereby gain a holistic view of the continuity between environmentally sustainable development, climate change adaptation and enhanced resilience. To promote effective multi-sectoral, interdisciplinary collaboration based on coordinated and integrated efforts, the intergovernmental Group on Earth Observations (GEO) is implementing the Global Earth Observation System of Systems (GEOSS). A component of GEOSS now under development is the "GEOSS Water Cycle Integrator (WCI)", which integrates Earth observations, modeling, data and information, management systems and education systems. GEOSS/WCI sets up "work benches" by which partners can share data, information and applications in an interoperable way, exchange knowledge and experiences, deepen mutual understanding and work together effectively to ultimately respond to issues of both mitigation and adaptation. (A work bench is a virtual geographical or phenomenological space where experts and managers collaborate to use information to address a problem within that space). GEOSS/WCI enhances the coordination of efforts to strengthen individual, institutional and infrastructure capacities, especially for effective interdisciplinary coordination and integration. GEO has established the GEOSS Asian Water Cycle Initiative (AWCI) and GEOSS African Water Cycle Coordination Initiative (AfWCCI). Through regional, inter-disciplinary, multi-sectoral integration and inter-agency coordination in Asia and Africa, GEOSS

  15. The Life Cycle of Centrioles

    OpenAIRE

    Hatch, E.; Stearns, T.

    2010-01-01

    Centrioles organize the centrosome and nucleate the ciliary axoneme, and the centriole life cycle has many parallels to the chromosome cycle. The centriole cycle in animals begins at fertilization with the contribution of two centrioles by the male gamete. In the ensuing cell cycles, the duplication of centrioles is controlled temporally, spatially, and numerically. As a consequence of the duplication mechanism, the two centrioles in a typical interphase cell are of different ages and have di...

  16. DETECTING ALIEN LIMIT CYCLES NEAR A HAMILTONIAN 2-SADDLE CYCLE

    OpenAIRE

    LUCA, Stijn; DUMORTIER, Freddy; Caubergh, M.; Roussarie, R.

    2009-01-01

    This paper aims at providing and example of a cubic Hamiltonian 2-saddle cycle that after bifurcation can give rise to an alien limit cycle; this is a limit cycle that is not controlled by a zero of the related Abelian integral. To guarantee the existence of an alien limit cycle one can verify generic conditions on the Abelian integral and on the transition map associated to the connections of the 2-saddle cycle. In this paper, a general method is developed to compute the first and second der...

  17. Optimum gas turbine cycle for combined cycle power plant

    International Nuclear Information System (INIS)

    Polyzakis, A.L.; Koroneos, C.; Xydis, G.

    2008-01-01

    The gas turbine based power plant is characterized by its relatively low capital cost compared with the steam power plant. It has environmental advantages and short construction lead time. However, conventional industrial engines have lower efficiencies, especially at part load. One of the technologies adopted nowadays for efficiency improvement is the 'combined cycle'. The combined cycle technology is now well established and offers superior efficiency to any of the competing gas turbine based systems that are likely to be available in the medium term for large scale power generation applications. This paper has as objective the optimization of a combined cycle power plant describing and comparing four different gas turbine cycles: simple cycle, intercooled cycle, reheated cycle and intercooled and reheated cycle. The proposed combined cycle plant would produce 300 MW of power (200 MW from the gas turbine and 100 MW from the steam turbine). The results showed that the reheated gas turbine is the most desirable overall, mainly because of its high turbine exhaust gas temperature and resulting high thermal efficiency of the bottoming steam cycle. The optimal gas turbine (GT) cycle will lead to a more efficient combined cycle power plant (CCPP), and this will result in great savings. The initial approach adopted is to investigate independently the four theoretically possible configurations of the gas plant. On the basis of combining these with a single pressure Rankine cycle, the optimum gas scheme is found. Once the gas turbine is selected, the next step is to investigate the impact of the steam cycle design and parameters on the overall performance of the plant, in order to choose the combined cycle offering the best fit with the objectives of the work as depicted above. Each alterative cycle was studied, aiming to find the best option from the standpoint of overall efficiency, installation and operational costs, maintainability and reliability for a combined power

  18. The nuclear fuel cycle

    International Nuclear Information System (INIS)

    1998-05-01

    After a short introduction about nuclear power in the world, fission physics and the French nuclear power plants, this brochure describes in a digest way the different steps of the nuclear fuel cycle: uranium prospecting, mining activity, processing of uranium ores and production of uranium concentrates (yellow cake), uranium chemistry (conversion of the yellow cake into uranium hexafluoride), fabrication of nuclear fuels, use of fuels, reprocessing of spent fuels (uranium, plutonium and fission products), recycling of energetic materials, and storage of radioactive wastes. (J.S.)

  19. Liquid air cycle engines

    Science.gov (United States)

    Rosevear, Jerry

    1992-01-01

    Given here is a definition of Liquid Air Cycle Engines (LACE) and existing relevant technologies. Heat exchanger design and fabrication techniques, the handling of liquid hydrogen to achieve the greatest heat sink capabilities, and air decontamination to prevent heat exchanger fouling are discussed. It was concluded that technology needs to be extended in the areas of design and fabrication of heat exchangers to improve reliability along with weight and volume reductions. Catalysts need to be improved so that conversion can be achieved with lower quantities and lower volumes. Packaging studies need to be investigated both analytically and experimentally. Recycling with slush hydrogen needs further evaluation with experimental testing.

  20. Cycle 7 outage experience

    International Nuclear Information System (INIS)

    Gadeken, A.D.

    1986-03-01

    The scheduled 58-day refueling outage in preparation for the seventh operating cycle of the Fast Flux Test Facility (FFTF) was successfully completed three days ahead of schedule. The planning and execution of the outage was greatly aided by Project/2 automated scheduling capabilities. For example, the use of ''maintenance windows'' and resource loading capabilities was particularly effective. The value of the planning process was demonstrated by the smooth transition into the outage phase after an early shutdown and set the stage for our best outage to date

  1. Nuclear Fuel Cycle Objectives

    International Nuclear Information System (INIS)

    2013-01-01

    . The four Objectives publications include Nuclear General Objectives, Nuclear Power Objectives, Nuclear Fuel Cycle Objectives, and Radioactive Waste management and Decommissioning Objectives. This publication sets out the objectives that need to be achieved in the area of the nuclear fuel cycle to ensure that the Nuclear Energy Basic Principles are satisfied. Within each of these four Objectives publications, the individual topics that make up each area are addressed. The five topics included in this publication are: resources; fuel engineering and performance; spent fuel management and reprocessing; fuel cycles; and the research reactor nuclear fuel cycle

  2. The software life cycle

    CERN Document Server

    Ince, Darrel

    1990-01-01

    The Software Life Cycle deals with the software lifecycle, that is, what exactly happens when software is developed. Topics covered include aspects of software engineering, structured techniques of software development, and software project management. The use of mathematics to design and develop computer systems is also discussed. This book is comprised of 20 chapters divided into four sections and begins with an overview of software engineering and software development, paying particular attention to the birth of software engineering and the introduction of formal methods of software develop

  3. Closing the fuel cycle

    International Nuclear Information System (INIS)

    Wolfe, B.; Judson, B.F.

    1984-01-01

    The possibilities for closing the fuel cycle in today's nuclear climate in the US are compared with those envisioned in 1977. Reprocessing, the fast breeder reactor program, and the uranium supply are discussed. The conclusion drawn is that the nuclear world is less healthy and less stable than the one previously envisioned and that the major task before the international nuclear community is to develop technologies, institutions, and accepted procedures that will allow to economically provide the huge store of energy from reprocessing and the breeder that it appears the world will desperately need

  4. Entrepreneurship and the Business Cycle

    NARCIS (Netherlands)

    Ph.D. Koellinger (Philipp); A.R. Thurik (Roy)

    2011-01-01

    textabstractWe find new empirical regularities in the business cycle in a cross-country panel of 22 OECD countries for the period 1972-2007; entrepreneurship Granger-causes the cycles of the world economy. Furthermore, the entrepreneurial cycle is positively affected by the national unemployment

  5. Sometimes "Newton's Method" Always "Cycles"

    Science.gov (United States)

    Latulippe, Joe; Switkes, Jennifer

    2012-01-01

    Are there functions for which Newton's method cycles for all non-trivial initial guesses? We construct and solve a differential equation whose solution is a real-valued function that two-cycles under Newton iteration. Higher-order cycles of Newton's method iterates are explored in the complex plane using complex powers of "x." We find a class of…

  6. Culture in cycles: considering H.T. Odum's 'information cycle'

    Science.gov (United States)

    Abel, Thomas

    2014-01-01

    'Culture' remains a conundrum in anthropology. When recast in the mold of 'information cycles,' culture is transformed. New fault lines appear. Information is splintered into parallel or nested forms. Dynamics becomes cycling. Energy is essential. And culture has function in a directional universe. The 'information cycle' is the crowning component of H.T. Odum's theory of general systems. What follows is an application of the information cycle to the cultural domains of discourse, social media, ritual, education, journalism, technology, academia, and law, which were never attempted by Odum. In information cycles, cultural information is perpetuated - maintained against Second Law depreciation. Conclusions are that culture is in fact a nested hierarchy of cultural forms. Each scale of information production is semi-autonomous, with its own evolutionary dynamics of production and selection in an information cycle. Simultaneously, each information cycle is channeled or entrained by its larger scale of information and ultimately human-ecosystem structuring.

  7. Cycling and bone health: a systematic review

    Directory of Open Access Journals (Sweden)

    Olmedillas Hugo

    2012-12-01

    Full Text Available Abstract Background Cycling is considered to be a highly beneficial sport for significantly enhancing cardiovascular fitness in individuals, yet studies show little or no corresponding improvements in bone mass. Methods A scientific literature search on studies discussing bone mass and bone metabolism in cyclists was performed to collect all relevant published material up to April 2012. Descriptive, cross-sectional, longitudinal and interventional studies were all reviewed. Inclusion criteria were met by 31 studies. Results Heterogeneous studies in terms of gender, age, data source, group of comparison, cycling level or modality practiced among others factors showed minor but important differences in results. Despite some controversial results, it has been observed that adult road cyclists participating in regular training have low bone mineral density in key regions (for example, lumbar spine. Conversely, other types of cycling (such as mountain biking, or combination with other sports could reduce this unsafe effect. These results cannot yet be explained by differences in dietary patterns or endocrine factors. Conclusions From our comprehensive survey of the current available literature it can be concluded that road cycling does not appear to confer any significant osteogenic benefit. The cause of this may be related to spending long hours in a weight-supported position on the bike in combination with the necessary enforced recovery time that involves a large amount of time sitting or lying supine, especially at the competitive level.

  8. S and H Cycle Engine

    International Nuclear Information System (INIS)

    Strobl, William C.; Holland, Joe P.

    2002-01-01

    Our thirst for energy is increasing at an astounding rate. World population growth is estimated to increase by 40% (to 8.5 billion) by 2050, with annual electrical energy usage estimated increase by 100% (to 25 terawatt-hours). We must find new means and fuels as well as significantly improve the efficiency of current power plants to accommodate this growing electrical energy demand. This demand is also growing in the field of space flight. Present energy and propulsion systems are limited in the amount of power (energy) that can be generated by today's technology. This limits the distance that can be safely traveled by manned and un-manned space systems. Space flight is primarily governed by two factors: time and energy. Increasing energy of space propulsion systems will decrease flight time or allow reaching farther out into space safely for manned exploration of our solar system. For example, a round trip manned mission to Mars would take about 400 days with a NERVA type thermal nuclear rocket. To reduce the 400 days to 80 days would require an increase of energy by a factor of five. We need to develop space propulsion systems with much greater energy capability than we have today to satisfy the expansion of space exploration. The S and H Cycle nuclear engine provides a revolutionary technological approach that can contribute significantly toward solving the World electrical energy and the space travel energy requirements. (authors)

  9. Erectile dysfunction and amatorial cycling.

    Science.gov (United States)

    Colpi, Giovanni Maria; Contalbi, Gianfranco; Ciociola, E; Mihalca, Radu

    2008-09-01

    Today cycling is considered a useful form of exercise for reducing cardiovascular risk, but it may also represent a risk factor for erectile dysfunction and perineal-genital paresthesia. These disorders are attributed to the local reduction of oxygen in the perineal-genital area, secondary to the perineal compression. Numerous studies have been carried out measuring the penile oxygen pressure or penile blood flow by echo-colour-Doppler: a reduced inflow of blood and oxygen to the cavernous tissue was demonstrated. The attention of the specialist is therefore concentrated on the compression of the perineum on the bicycle saddle and how to reduce this through the position of the cyclist on the bicycle (i.e. height and tilt of the saddle), the different shapes of saddle available (i.e. noseless, grooved, wide, etc.) and the padding materials of the saddle. In order to reduce perineal compression, the posterior part of the saddle should be as wide as the distance between the two ischiatic tuberosities. In addition, the saddle should be studied on the basis of the biotype of the cyclist: ectomorphic, mesomorphic or endomorphic. However, in the genesis of the erectile dysfunction of the cyclist, apart from the above-mentioned factors, an "individual predisposition to developing erectile dysfunction" linked to the perineal-genital anatomy (i.e. type of insertion of the perineum into the root of the penis, number of layers of the tunica albuginea of the corpus cavernosum) cannot be excluded.

  10. Issues in the selection of the LMFBR steam cycle

    International Nuclear Information System (INIS)

    Buschman, H.W.; McConnell, R.J.

    1983-01-01

    Unlike the light-water reactor, the liquid-metal fast breeder reactor (LMFBR) allows the designer considerable latitude in the selection of the steam cycle. This latitude in selection has been exercised by both foreign and domestic designers, and thus, despite the fact that over 25 LMFBR's have been built or are under construction, a consensus steam cycle has not yet evolved. This paper discusses the LMFBR steam cycles of interest to the LMFBR designer, reviews which of these cycles have been employed to date, discusses steam-cycle selection factors, discusses why a consensus has not evolved, and finally, concludes that the LMFBR steam-cycle selection is primarily one of technical philosophy with several options available

  11. Thermodynamic cycle calculations for a pumped gaseous core fission reactor

    International Nuclear Information System (INIS)

    Kuijper, J.C.; Van Dam, H.

    1991-01-01

    Finite and 'infinitesimal' thermodynamic cycle calculations have been performed for a 'solid piston' model of a pumped Gaseous Core Fission Reactor with dissociating reactor gas, consisting of Uranium, Carbon and Fluorine ('UCF'). In the finite cycle calculations the influence has been investigated of several parameters on the thermodynamics of the system, especially on the attainable direct (nuclear to electrical) energy conversion efficiency. In order to facilitate the investigation of the influence of dissociation, a model gas, 'Modelium', was developed, which approximates, in a simplified, analytical way, the dissociation behaviour of the 'real' reactor gas. Comparison of the finite cycle calculation results with those of a so-called infinitesimal Otto cycle calculation leads to the conclusion that the conversion efficiency of a finite cycle can be predicted, without actually performing the finite cycle calculation, with reasonable accuracy, from the so-called 'infinitesimal efficiency factor', which is determined only by the thermodynamic properties of the reactor gas used. (author)

  12. The sunspot cycle revisited

    International Nuclear Information System (INIS)

    Lomb, Nick

    2013-01-01

    The set of sunspot numbers observed since the invention of the telescope is one of the most studied time series in astronomy and yet it is also one of the most complex. Fourteen frequencies are found in the yearly mean sunspot numbers from 1700 to 2011using the Lomb-Scargle periodogram and prewhitening. All of the frequencies corresponding to shorter term periods can be matched with simple algebraic combinations of the frequency of the main 11-year period and the frequencies of the longer term periods in the periodogram. This is exactly what can be expected from amplitude and phase modulation of an 11.12-year periodicity by longer term variations. Similar, though not identical, results are obtained after correcting the sunspot number series as proposed by Svalgaard. On looking separately at the amplitude and phase modulation a clear relationship is found between the two modulations although this relationship has broken down for the last four solar cycles. The phase modulation implies that there is a definite underlying period for the solar cycle. Such a clock mechanism does seem to be a possibility in models of the solar dynamo incorporating a conveyor-belt-like meridional circulation between high polar latitudes and the equator.

  13. Reference thorium fuel cycle

    International Nuclear Information System (INIS)

    Driggers, F.E.

    1978-08-01

    In the reference fuel cycle for the TFCT program, fissile U will be denatured by mixing with 238 U; the plants will be located in secure areas, with Pu being recycled within these secure areas; Th will be recycled with recovered U and Pu; the head end will handle a variety of core and blanket fuel assembly designs for LWRs and HWRs; the fuel may be a homogeneous mixture either of U and Th oxide pellets or sol-gel microspheres; the cladding will be Zircaloy; and MgO may be added to the fuel to improve Th dissolution. Th is being considered as the fertile component of fuel in order to increase proliferation resistance. Spent U recovered from Th-based fuels must be re-enriched before recycle to prevent very rapid buildup of 238 U. Stainless steel will be considered as a backup to Zircaloy cladding in case Zr is incompatible with commercial aqueous dissolution. Storage of recovered irradiated Th will be considered as a backup to its use in the recycle of recovered Pu and U. Estimates are made of the time for introducing the Th fuel cycle into the LWR power industry. Since U fuel exposures in LWRs are likely to increase from 30,000 to 50,000 MWD/MT, the Th reprocessing plant should also be designed for Th fuel with 50,000 MWD/MT exposure

  14. Fast breeder fuel cycle

    International Nuclear Information System (INIS)

    1978-07-01

    This contribution is prepared for the answer to the questionnaire of working group 5, subgroup B. B.1. is the short review of the fast breeder fuel cycles based on the reference large commercial Japanese LMFBR. The LMFBRs are devided into two types. FBR-A is the reactor to be used before 2000, and its burnup and breeding ratio are relatively low. The reference fuel cycle requirement is calculated based on the FBR-A. FBR-B is the one to be used after 2000, and its burnup and breeding ratio are relatively high. B.2. is basic FBR fuel reprocessing scheme emphasizing the differences with LWR reprocessing. This scheme is based on the conceptual design and research and development work on the small scale LMFBR reprocessing facility of Japan. The facility adopts a conventional PUREX process except head end portions. The report also describes the effects of technical modifications of conventional reprocessing flow sheets, and the problems to be solved before the adoption of these alternatives

  15. Changing global carbon cycle

    International Nuclear Information System (INIS)

    Canadell, Pep

    2007-01-01

    Full text: The increase in atmospheric carbon dioxide (C02) is the single largest human perturbation on the earth's radiative balance contributing to climate change. Its rate of change reflects the balance between anthropogenic carbon emissions and the dynamics of a number of terrestrial and ocean processes that remove or emit C02. It is the long term evolution of this balance that will determine to large extent the speed and magnitude of the human induced climate change and the mitigation requirements to stabilise atmospheric C02 concentrations at any given level. In this talk, we show new trends in global carbon sources and sinks, with particularly focus on major shifts occurring since 2000 when the growth rate of atmospheric C02 has reached its highest level on record. The acceleration in the C02 growth results from the combination of several changes in properties of the carbon cycle, including: acceleration of anthropogenic carbon emissions; increased carbon intensity of the global economy, and decreased efficiency of natural carbon sinks. We discuss in more detail some of the possible causes of the reduced efficiency of natural carbon sinks on land and oceans, such as the decreased net sink in the Southern Ocean and on terrestrial mid-latitudes due to world-wide occurrence of drought. All these changes reported here characterise a carbon cycle that is generating stronger than expected climate forcing, and sooner than expected

  16. Global biogeochemical cycle of vanadium.

    Science.gov (United States)

    Schlesinger, William H; Klein, Emily M; Vengosh, Avner

    2017-12-26

    Synthesizing published data, we provide a quantitative summary of the global biogeochemical cycle of vanadium (V), including both human-derived and natural fluxes. Through mining of V ores (130 × 10 9 g V/y) and extraction and combustion of fossil fuels (600 × 10 9 g V/y), humans are the predominant force in the geochemical cycle of V at Earth's surface. Human emissions of V to the atmosphere are now likely to exceed background emissions by as much as a factor of 1.7, and, presumably, we have altered the deposition of V from the atmosphere by a similar amount. Excessive V in air and water has potential, but poorly documented, consequences for human health. Much of the atmospheric flux probably derives from emissions from the combustion of fossil fuels, but the magnitude of this flux depends on the type of fuel, with relatively low emissions from coal and higher contributions from heavy crude oils, tar sands bitumen, and petroleum coke. Increasing interest in petroleum derived from unconventional deposits is likely to lead to greater emissions of V to the atmosphere in the near future. Our analysis further suggests that the flux of V in rivers has been incremented by about 15% from human activities. Overall, the budget of dissolved V in the oceans is remarkably well balanced-with about 40 × 10 9 g V/y to 50 × 10 9 g V/y inputs and outputs, and a mean residence time for dissolved V in seawater of about 130,000 y with respect to inputs from rivers.

  17. Part 5. Fuel cycle options

    International Nuclear Information System (INIS)

    Lineberry, M.J.; McFarlane, H.F.; Amundson, P.I.; Goin, R.W.; Webster, D.S.

    1980-01-01

    The results of the FBR fuel cycle study that supported US contributions to the INFCE are presented. Fuel cycle technology is reviewed from both generic and historical standpoints. Technology requirements are developed within the framework of three deployment scenarios: the reference international, the secured area, and the integral cycle. Reprocessing, fabrication, waste handling, transportation, and safeguards are discussed for each deployment scenario. Fuel cycle modifications designed to increase proliferation defenses are described and assessed for effectiveness and technology feasibility. The present status of fuel cycle technology is reviewed and key issues that require resolution are identified

  18. Ammonia-water Rankine cycle

    International Nuclear Information System (INIS)

    Bo Hanliang; Ma Changwen; Wu Shaorong

    1997-01-01

    On characteristics of heating source and cooling source in nuclear heating reactor cooperation, the authors advance a new kind of power cycle in which a multicomponent mixture as the work fluid, ammonia-water Rankine cycle, describe its running principle, and compare it with steam Rankine cycle in the same situation. The result is that: the new kind of power cycle, ammonia-water Rankine cycle has higher electricity efficiency; it suits for the situation of heating source and cooling source which offered by nuclear heating reactor cooperation. For low temperature heating source, it maybe has a widely application

  19. Cycling infrastructure for reducing cycling injuries in cyclists.

    Science.gov (United States)

    Mulvaney, Caroline A; Smith, Sherie; Watson, Michael C; Parkin, John; Coupland, Carol; Miller, Philip; Kendrick, Denise; McClintock, Hugh

    2015-12-10

    Cycling is an attractive form of transport. It is beneficial to the individual as a form of physical activity that may fit more readily into an individual's daily routine, such as for cycling to work and to the shops, than other physical activities such as visiting a gym. Cycling is also beneficial to the wider community and the environment as a result of fewer motorised journeys. Cyclists are seen as vulnerable road users who are frequently in close proximity to larger and faster motorised vehicles. Cycling infrastructure aims to make cycling both more convenient and safer for cyclists. This review is needed to guide transport planning. To:1. evaluate the effects of different types of cycling infrastructure on reducing cycling injuries in cyclists, by type of infrastructure;2. evaluate the effects of cycling infrastructure on reducing the severity of cycling injuries in cyclists;3. evaluate the effects of cycling infrastructure on reducing cycling injuries in cyclists with respect to age, sex and social group. We ran the most recent search on 2nd March 2015. We searched the Cochrane Injuries Group Specialised Register, CENTRAL (The Cochrane Library), MEDLINE (OvidSP), Embase Classic + Embase(OvidSP), PubMed and 10 other databases. We searched websites, handsearched conference proceedings, screened reference lists of included studies and previously published reviews and contacted relevant organisations. We included randomised controlled trials, cluster randomised controlled trials, controlled before-after studies, and interrupted time series studies which evaluated the effect of cycling infrastructure (such as cycle lanes, tracks or paths, speed management, roundabout design) on cyclist injury or collision rates. Studies had to include a comparator, that is, either no infrastructure or a different type of infrastructure. We excluded studies that assessed collisions that occurred as a result of competitive cycling. Two review authors examined the titles and

  20. On cycles in the transcription network of Saccharomyces cerevisiae

    Directory of Open Access Journals (Sweden)

    Berman Piotr

    2008-01-01

    Full Text Available Abstract Background We investigate the cycles in the transcription network of Saccharomyces cerevisiae. Unlike a similar network of Escherichia coli, it contains many cycles. We characterize properties of these cycles and their place in the regulatory mechanism of the cell. Results Almost all cycles in the transcription network of Saccharomyces cerevisiae are contained in a single strongly connected component, which we call LSCC (L for "largest", except for a single cycle of two transcription factors. The fact that LSCC includes almost all cycles is well explained by the properties of a random graph with the same in- and out-degrees of the nodes. Among different physiological conditions, cell cycle has the most significant relationship with LSCC, as the set of 64 transcription interactions that are active in all phases of the cell cycle has overlap of 27 with the interactions of LSCC (of which there are 49. Conversely, if we remove the interactions that are active in all phases of the cell cycle (25% of interactions to transcription factors, the LSCC would have only three nodes and 5 edges, many fewer than expected. This subgraph of the transcription network consists mostly of interactions that are active only in the stress response subnetwork. We also characterize the role of LSCC in the topology of the network. We show that LSCC can be used to define a natural hierarchy in the network and that in every physiological subnetwork LSCC plays a pivotal role. Conclusion Apart from those well-defined conditions, the transcription network of Saccharomyces cerevisiae is devoid of cycles. It was observed that two conditions that were studied and that have no cycles of their own are exogenous: diauxic shift and DNA repair, while cell cycle and sporulation are endogenous. We claim that in a certain sense (slow recovery stress response is endogenous as well.

  1. Chalepin: A Compound from Ruta angustifolia L. Pers Exhibits Cell Cycle Arrest at S phase, Suppresses Nuclear Factor-Kappa B (NF-κB) Pathway, Signal Transducer and Activation of Transcription 3 (STAT3) Phosphorylation and Extrinsic Apoptotic Pathway in Non-small Cell Lung Cancer Carcinoma (A549).

    Science.gov (United States)

    Richardson, Jaime Stella Moses; Aminudin, Norhaniza; Abd Malek, Sri Nurestri

    2017-10-01

    Plants have been a major source of inspiration in developing novel drug compounds in the treatment of various diseases that afflict human beings worldwide. Ruta angustifolia L. Pers known locally as Garuda has been conventionally used for various medicinal purposes such as in the treatment of cancer. A dihydrofuranocoumarin named chalepin, which was isolated from the chloroform extract of the plant, was tested on its ability to inhibit molecular pathways of human lung carcinoma (A549) cells. Cell cycle analysis and caspase 8 activation were conducted using a flow cytometer, and protein expressions in molecular pathways were determined using Western blot technique. Cell cycle analysis showed that cell cycle was arrested at the S phase. Further studies using Western blotting technique showed that cell cycle-related proteins such as cyclins, cyclin-dependent kinases (CDKs), and inhibitors of CDKs correspond to a cell cycle arrest at the S phase. Chalepin also showed inhibition in the expression of inhibitors of apoptosis proteins. Nuclear factor-kappa B (NF-κB) pathway, signal transducer and activation of transcription 3 (STAT-3), cyclooxygenase-2, and c-myc were also downregulated upon treatment with chalepin. Chalepin was found to induce extrinsic apoptotic pathway. Death receptors 4 and 5 showed a dramatic upregulation at 24 h. Analysis of activation of caspase 8 with the flow cytometer showed an increase in activity in a dose- and time-dependent manner. Activation of caspase 8 induced cleavage of BH3-interacting domain death agonist, which initiated a mitochondrial-dependent or -independent apoptosis. Chalepin causes S phase cell cycle arrest, NF-κB pathway inhibition, and STAT-3 inhibition, induces extrinsic apoptotic pathway, and could be an excellent chemotherapeutic agent. This study reports the capacity of an isolated bioactive compound known as chalepin to suppress the nuclear factor kappa-light-chain-enhancer of activated B cells pathway, signal

  2. Increased production of functional recombinant human clotting factor IX by baby hamster kidney cells engineered to overexpress VKORC1, the vitamin K 2,3-epoxide-reducing enzyme of the vitamin K cycle.

    Science.gov (United States)

    Wajih, Nadeem; Hutson, Susan M; Owen, John; Wallin, Reidar

    2005-09-09

    Some recombinant vitamin K-dependent blood coagulation factors (factors VII, IX, and protein C) have become valuable pharmaceuticals in the treatment of bleeding complications and sepsis. Because of their vitamin K-dependent post-translational modification, their synthesis by eukaryotic cells is essential. The eukaryotic cell harbors a vitamin K-dependent gamma-carboxylation system that converts the proteins to gamma-carboxyglutamic acid-containing proteins. However, the system in eukaryotic cells has limited capacity, and cell lines overexpressing vitamin K-dependent clotting factors produce only a fraction of the recombinant proteins as fully gamma-carboxylated, physiologically competent proteins. In this work we have used recombinant human factor IX (r-hFIX)-producing baby hamster kidney (BHK) cells, engineered to stably overexpress various components of the gamma-carboxylation system of the cell, to determine whether increased production of functional r-hFIX can be accomplished. All BHK cell lines secreted r-hFIX into serum-free medium. Overexpression of gamma-carboxylase is shown to inhibit production of functional r-hFIX. On the other hand, cells overexpressing VKORC1, the reduced vitamin K cofactor-producing enzyme of the vitamin K-dependent gamma-carboxylation system, produced 2.9-fold more functional r-hFIX than control BHK cells. The data are consistent with the notion that VKORC1 is the rate-limiting step in the system and is a key regulatory protein in synthesis of active vitamin K-dependent proteins. The data suggest that overexpression of VKORC1 can be utilized for increased cellular production of recombinant vitamin K-dependent proteins.

  3. Tumor regression induced by intratumor therapy with a disabled infectious single cycle (DISC) herpes simplex virus (HSV) vector, DISC/HSV/murine granulocyte-macrophage colony-stimulating factor, correlates with antigen-specific adaptive immunity.

    Science.gov (United States)

    Ali, Selman A; Lynam, June; McLean, Cornelia S; Entwisle, Claire; Loudon, Peter; Rojas, José M; McArdle, Stephanie E B; Li, Geng; Mian, Shahid; Rees, Robert C

    2002-04-01

    Direct intratumor injection of a disabled infectious single cycle HSV-2 virus encoding the murine GM-CSF gene (DISC/mGM-CSF) into established murine colon carcinoma CT26 tumors induced a significant delay in tumor growth and complete tumor regression in up to 70% of animals. Pre-existing immunity to HSV did not reduce the therapeutic efficacy of DISC/mGM-CSF, and, when administered in combination with syngeneic dendritic cells, further decreased tumor growth and increased the incidence of complete tumor regression. Direct intratumor injection of DISC/mGM-CSF also inhibited the growth of CT26 tumor cells implanted on the contralateral flank or seeded into the lungs following i.v. injection of tumor cells (experimental lung metastasis). Proliferation of splenocytes in response to Con A was impaired in progressor and tumor-bearer, but not regressor, mice. A potent tumor-specific CTL response was generated from splenocytes of all mice with regressing, but not progressing tumors following in vitro peptide stimulation; this response was specific for the gp70 AH-1 peptide SPSYVYHQF and correlated with IFN-gamma, but not IL-4 cytokine production. Depletion of CD8(+) T cells from regressor splenocytes before in vitro stimulation with the relevant peptide abolished their cytolytic activity, while depletion of CD4(+) T cells only partially inhibited CTL generation. Tumor regression induced by DISC/mGM-CSF virus immunotherapy provides a unique model for evaluating the immune mechanism(s) involved in tumor rejection, upon which tumor immunotherapy regimes may be based.

  4. LIFE CYCLE OF INFORMATION SYSTEMS

    Directory of Open Access Journals (Sweden)

    Y. S. Sennik

    2015-01-01

    Full Text Available This work is a generalization of the theoretical propositions related to the life cycle of information systems. There was given the definition of the life cycle, specify which items you should include every step of the cycle. Describes the methodology division of the life cycle on the main stage, including methodology Rational Unified Process. The description of the fundamental standards in this area. Special attention was paid to the work of the basic life cycle models. It was carried out their comparative characteristics. On the basis of the theoretical propositions, it was concluded that the preferred model of the life cycle for the corporate network is a spiral model and the use of international standards in the life cycle saves a lot of effort, time and material resources.

  5. Partially closed fuel cycle of WWER-440

    International Nuclear Information System (INIS)

    Darilek, P.; Sebian, V.; Necas, V.

    2002-01-01

    Position of nuclear energy at the energy sources competition is characterised briefly. Multi-tier transmutation system is outlined out as effective back-end solution and consequently as factor that can increase nuclear energy competitiveness. LWR and equivalent WWER are suggested as a first tier reactors. Partially closed fuel cycle with combined fuel assemblies is briefed. Main back-end effects are characterised (Authors)

  6. Understanding the Evolution of World Business Cycles

    OpenAIRE

    Ayhan Kose; Christopher Otrok; Charles H. Whiteman

    2005-01-01

    This paper studies the changes in world business cycles during 1960-2003. We employ a Bayesian dynamic latent factor model to estimate common and country-specific components in the main macroeconomic aggregates of the Group of Seven (G-7) countries. We then quantify the relative importance of these components in explaining comovement in each observable aggregate over three distinct time periods: the Bretton Woods (BW) period (1960-72), the period of common shocks (1972-86), and the globalizat...

  7. Solar cycle variations of magnetopause locations

    Czech Academy of Sciences Publication Activity Database

    Němeček, Z.; Šafránková, J.; Lopez, R. E.; Dušík, Š.; Nouzák, L.; Přech, J.; Šimůnek, Jiří; Shue, J.-H.

    2016-01-01

    Roč. 58, č. 2 (2016), s. 240-248 ISSN 0273-1177 R&D Projects: GA ČR(CZ) GA14-19376S Institutional support: RVO:68378289 Keywords : magnetopause location * F-10.7 flux * solar cycle * solar wind velocity Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 1.401, year: 2016 http://www.sciencedirect.com/science/article/pii/S0273117715007115

  8. The supercontinent cycle

    Energy Technology Data Exchange (ETDEWEB)

    Nance, R.D.; Worsley, T.R.; Moody, J.B.

    1988-07-01

    This paper discusses a new theory of plate tectonics which proposes that Pangaea was only the most recent in a series of supercontinents that have been breaking up and reassembling every 500 million years or so. The cycle, driven by heat percolating up from the mantle, splits continents and drives interrelated processes that shape the earth's geology and climate and play a role in biological evolution. The framework of the supercontinent theory makes it possible to understand the timing of changes in sea level that have taken place in the past 570 million years, and also helps to explain periods of intense mountain building, episodes of glaciation, and changes in the nature of life on the earth.

  9. The nuclear power cycle

    International Nuclear Information System (INIS)

    2004-01-01

    Fifty years after the first nuclear reactor come on-line, nuclear power is fourth among the world's primary energy sources, after oil, coal and gas. In 2002, there were 441 reactors in operation worldwide. The United States led the world with 104 reactors and an installed capacity of 100,000 MWe, or more than one fourth of global capacity. Electricity from nuclear energy represents 78% of the production in France, 57% in Belgium, 46% in Sweden, 40% in Switzerland, 39% in South Korea, 34% in Japan, 30% in Germany, 30% in Finland, 26% in Spain, 22% in Great Britain, 20% in the United States and 16% in Russia. Worldwide, 32 reactors are under construction, including 21 in Asia. This information document presents the Areva activities in the nuclear power cycle: the nuclear fuel, the nuclear reactors, the spent fuel reprocessing and recycling and nuclear cleanup and dismantling. (A.L.B.)

  10. CANDU advanced fuel cycles

    International Nuclear Information System (INIS)

    Slater, J.B.

    1986-03-01

    This report is based on informal lectures and presentations made on CANDU Advanced Fuel Cycles over the past year or so, and discusses the future role of CANDU in the changing environment for the Canadian and international nuclear power industry. The changing perspectives of the past decade lead to the conclusion that a significant future market for a CANDU advanced thermal reactor will exist for many decades. Such a reactor could operate in a stand-alone strategy or integrate with a mixed CANDU-LWR or CANDU-FBR strategy. The consistent design focus of CANDU on enhanced efficiency of resource utilization combined with a simple technology to achieve economic targets, will provide sufficient flexibility to maintain CANDU as a viable power producer for both the medium- and long-term future

  11. Open cycle thermoacoustics

    Energy Technology Data Exchange (ETDEWEB)

    Reid, Robert Stowers [Georgia Inst. of Technology, Atlanta, GA (United States)

    2000-01-01

    A new type of thermodynamic device combining a thermodynamic cycle with the externally applied steady flow of an open thermodynamic process is discussed and experimentally demonstrated. The gas flowing through this device can be heated or cooled in a series of semi-open cyclic steps. The combination of open and cyclic flows makes possible the elimination of some or all of the heat exchangers (with their associated irreversibility). Heat is directly exchanged with the process fluid as it flows through the device when operating as a refrigerator, producing a staging effect that tends to increase First Law thermodynamic efficiency. An open-flow thermoacoustic refrigerator was built to demonstrate this concept. Several approaches are presented that describe the physical characteristics of this device. Tests have been conducted on this refrigerator with good agreement with a proposed theory.

  12. Variable cycle engine

    Energy Technology Data Exchange (ETDEWEB)

    Adamson, A.P.; Sprunger, E.V.

    1980-09-16

    A variable cycle turboshaft engine includes a remote fan system and respective high and low pressure systems for selectively driving the fan system in such a manner as to provide VTOL takeoff capability and minimum specific fuel consumption (SFC) at cruise and loiter conditions. For takeoff the fan system is primarily driven by the relatively large low pressure system whose combustor receives the motive fluid from a core bypass duct and, for cruise and loiter conditions, the fan system is driven by both a relatively small high pressure core and the low pressure system with its combustor inoperative. A mixer is disposed downstream of the high pressure system for mixing the relatively cold air from the bypass duct and the relatively hot air from the core prior to its flow to the low pressure turbine.

  13. HTGR fuel cycle

    International Nuclear Information System (INIS)

    1987-08-01

    In the spring of 1987, the HTGR fuel cycle project has been existing for ten years, and for this reason a status seminar has been held on May 12, 1987 in the Juelich Nuclear Research Center, that gathered the participants in this project for a discussion on the state of the art in HTGR fuel element development, graphite development, and waste management. The papers present an overview of work performed so far and an outlook on future tasks and goals, and on taking stock one can say that the project has been very successful so far: The HTGR fuel element now available meets highest requirements and forms the basis of today's HTGR safety philosophy; research work on graphite behaviour in a high-temperature reactor has led to complete knowledge of the temperature or neutron-induced effects, and with the concept of direct ultimate waste disposal, the waste management problem has found a feasible solution. (orig./GL) [de

  14. Regional Business Cycles in East Asia: Synchronization and its Determinants

    Directory of Open Access Journals (Sweden)

    Young-Joon Park

    2013-06-01

    Full Text Available This paper analyzes the dynamics and nature of regional business cycle synchronization for East Asian countries in the period of 2000:Q1-2011:Q4. Estimating a dynamic two-factor model extracts the common factor and the nation- specific factor from both the macroeconomic aggregates and plausible driving forces of regional business cycles. Evidence for regional business cycle synchronization is particularly strong for Korea, Malaysia and the Philippines, while Japan shows weak evidence of regional synchronization. On the other hand, Indonesia, Thailand, Singapore and China are decoupling from regional business cycles. The driver of monetary aggregate is the most significant determinant of regional fluctuations of macroeconomic aggregates, whereas oil price and productivity are on average important driving forces of nation-specific fluctuations of real economic activities.

  15. Regional nuclear fuel cycle centers study project

    International Nuclear Information System (INIS)

    Bennett, L.; Catlin, R.G.; Meckoni, V.

    1977-01-01

    The concept of regional fuel cycle centers (RFCC) has attracted wide interest. The concept was endorsed by many countries in discussions at the General Conference of the International Atomic Energy Agency and at the General Assembly of the United Nations. Accordingly, in 1975, the IAEA initiated a detailed study of the RFCC concept. The Agency study has concentrated on what is referred to as the ''back-end'' of the fuel cycle because that is the portion which is currently problematic. The study covers transport, storage, processing and recycle activities starting from the time the spent fuel leaves the reactor storage pools and through all steps until the recycled fuel is in finished fuel elements and shipped to the reactor. A detailed evaluation of the specific features of large regional fuel cycle centers established on a multinational basis vis-a-vis smaller dispersed fuel cycle facilities set up on a national basis has been carried out. The methodology for assessment of alternative strategies for fuel storage, reprocessing, and recycling of plutonium has been developed, characteristic data on material flows and cost factors have been generated, and an analytic system has been developed to carry out such evaluations including appropriate sensitivity analysis. Studies in related areas on institutional and legal, organizational, environmental, materials control and other essential aspects have also been made. The material developed during the course of this Study would enable any group of interested Member States to examine and work out alternative strategies pertinent to their present and projected nuclear fuel cycle needs, as well as evolve institutional, legal and other appropriate frameworks or agreements for the establishment of fuel cycle centers on a multinational cooperative basis

  16. The Hamburg oceanic carbon cycle circulation model. Cycle 1

    International Nuclear Information System (INIS)

    Maier-Reimer, E.; Heinze, C.

    1992-02-01

    The carbon cycle model calculates the prognostic fields of oceanic geochemical carbon cycle tracers making use of a 'frozen' velocity field provided by a run of the LSG oceanic circulation model (see the corresponding manual, LSG=Large Scale Geostrophic). The carbon cycle model includes a crude approximation of interactions between sediment and bottom layer water. A simple (meridionally diffusive) one layer atmosphere model allows to calculate the CO 2 airborne fraction resulting from the oceanic biogeochemical interactions. (orig.)

  17. Creeping of hysteresis cycles; Reptation des cycles d'hysteresis

    Energy Technology Data Exchange (ETDEWEB)

    Neel, L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Faculte des Sciences de Grenoble, 38 (France)

    1959-07-01

    Creeping consists of a kind of progressive translation of dissymmetric ferromagnetic hysteresis cycles as a function of the order number of the cycle. It is interpreted here by means of a probable coupling field, the existence of which is connected to a statistical conception of the distribution of the elementary regions. (author) [French] La reptation consiste en une sorte de translation progressive des cycles d'hysteresis ferromagnetiques dissymetriques en fonction du numero d'ordre du cycle. L'auteur l'interprete au moyen d'un champ aleatoire de couplage dont l'existence est liee a une conception statistique de la distribution des domaines elementaires. (auteur)

  18. Gender differences in recreational and transport cycling: a cross-sectional mixed-methods comparison of cycling patterns, motivators, and constraints.

    Science.gov (United States)

    Heesch, Kristiann C; Sahlqvist, Shannon; Garrard, Jan

    2012-09-08

    Gender differences in cycling are well-documented. However, most analyses of gender differences make broad comparisons, with few studies modeling male and female cycling patterns separately for recreational and transport cycling. This modeling is important, in order to improve our efforts to promote cycling to women and men in countries like Australia with low rates of transport cycling. The main aim of this study was to examine gender differences in cycling patterns and in motivators and constraints to cycling, separately for recreational and transport cycling. Adult members of a Queensland, Australia, community bicycling organization completed an online survey about their cycling patterns; cycling purposes; and personal, social and perceived environmental motivators and constraints (47% response rate). Closed and open-end questions were completed. Using the quantitative data, multivariable linear, logistic and ordinal regression models were used to examine associations between gender and cycling patterns, motivators and constraints. The qualitative data were thematically analyzed to expand upon the quantitative findings. In this sample of 1862 bicyclists, men were more likely than women to cycle for recreation and for transport, and they cycled for longer. Most transport cycling was for commuting, with men more likely than women to commute by bicycle. Men were more likely to cycle on-road, and women off-road. However, most men and women did not prefer to cycle on-road without designed bicycle lanes, and qualitative data indicated a strong preference by men and women for bicycle-only off-road paths. Both genders reported personal factors (health and enjoyment related) as motivators for cycling, although women were more likely to agree that other personal, social and environmental factors were also motivating. The main constraints for both genders and both cycling purposes were perceived environmental factors related to traffic conditions, motorist aggression and

  19. Gender differences in recreational and transport cycling: a cross-sectional mixed-methods comparison of cycling patterns, motivators, and constraints

    Directory of Open Access Journals (Sweden)

    Heesch Kristiann C

    2012-09-01

    Full Text Available Abstract Background Gender differences in cycling are well-documented. However, most analyses of gender differences make broad comparisons, with few studies modeling male and female cycling patterns separately for recreational and transport cycling. This modeling is important, in order to improve our efforts to promote cycling to women and men in countries like Australia with low rates of transport cycling. The main aim of this study was to examine gender differences in cycling patterns and in motivators and constraints to cycling, separately for recreational and transport cycling. Methods Adult members of a Queensland, Australia, community bicycling organization completed an online survey about their cycling patterns; cycling purposes; and personal, social and perceived environmental motivators and constraints (47% response rate. Closed and open-end questions were completed. Using the quantitative data, multivariable linear, logistic and ordinal regression models were used to examine associations between gender and cycling patterns, motivators and constraints. The qualitative data were thematically analyzed to expand upon the quantitative findings. Results In this sample of 1862 bicyclists, men were more likely than women to cycle for recreation and for transport, and they cycled for longer. Most transport cycling was for commuting, with men more likely than women to commute by bicycle. Men were more likely to cycle on-road, and women off-road. However, most men and women did not prefer to cycle on-road without designed bicycle lanes, and qualitative data indicated a strong preference by men and women for bicycle-only off-road paths. Both genders reported personal factors (health and enjoyment related as motivators for cycling, although women were more likely to agree that other personal, social and environmental factors were also motivating. The main constraints for both genders and both cycling purposes were perceived environmental factors

  20. Economic evaluation of multilateral nuclear fuel cycle approach

    International Nuclear Information System (INIS)

    Takashima, Ryuta; Kuno, Yusuke; Omoto, Akira; Tanaka, Satoru

    2011-01-01

    Recently previous works have shown that multilateral nuclear fuel cycle approach has benefits not only of non-proliferation but also of cost effectiveness. This is because for most facilities in nuclear fuel cycle, there exist economies of scale, which has a significant impact on the costs of nuclear fuel cycle. Therefore, the evaluation of economic rationality is required as one of the evaluation factors for the multilateral nuclear fuel cycle approach. In this study, we consider some options with respect to multilateral approaches to nuclear fuel cycle in Asian-Pacific region countries that are proposed by the University of Tokyo. In particular, the following factors are embedded into each type: A) no involvement of assurance of services, B) provision of assurance of services including construction of new facility, without transfer of ownership, and C) provision of assurance of service including construction of new joint facilities with ownership transfer of facilities to multilateral nuclear fuel cycle approach. We show the overnight costs taking into account install and operation of nuclear fuel cycle facilities for each option. The economic parameter values such as uranium price, scale factor, and market output expansion influences the total cost for each option. Thus, we show how these parameter values and economic risks affect the total overnight costs for each option. Additionally, the international facilities could increase the risk of transportation for nuclear material compared to national facilities. We discuss the potential effects of this transportation risk on the costs for each option. (author)

  1. In anticipation of cycle 24

    Science.gov (United States)

    Kunches, Joseph; van der Linden, Ronald; Lundstedt, Henrik

    Anxious eyes are watching for the beginnings of new solar cycle 24. The watchers are many; scientists, engineers, academics, forecasters, end users. Their needs however vary, from the attraction of a better understanding of our nearest star, to how its increase in luminosity will affect particular aspects such as satellite orbits or the strength of the episodic storms that are most likely to occur during the height of the cycle. The first sign, however fleeting, occurred in January, 2008, when an ephemeral new cycle spot was numbered by NOAA as 10981. It was gone quickly but did mark the possible beginning of the new cycle. There has been great debate among solar physicists on how strong cycle 24 will be; and when it will start, reach maximum, and decline. This talk will give the status of the efforts to predict cycle 24, and the most recent projections.

  2. Menstrual cycle pattern and fertility

    DEFF Research Database (Denmark)

    Kolstad, Henrik A.; Bonde, Jens Peter; Hjøllund, Niels Henrik

    1999-01-01

    OBJECTIVE: To characterize how the menstrual cycle pattern relates to fertility regardless of potential biases caused by inappropriate coital timing during the menstrual cycle or early embryonal loss. DESIGN: Prospective follow-up study. SETTING: Healthy couples recruited throughout Denmark....... PATIENT(S): Two hundred ninety-five couples who were planning their first pregnancy were followed up from the discontinuation of birth control until a pregnancy was recognized within six menstrual cycles. Early embryonal losses were detected by changes in urinary hCG levels. INTERVENTION(S): None. MAIN...... OUTCOME MEASURE(S): The probability of pregnancy occurring within one menstrual cycle (fecundity). RESULT(S): In women who had a cycle length that differed by >10 days from the usual cycle length, fecundity was approximately 25% that of women who had no variation (odds ratio 0.25, 95% confidence interval...

  3. The Global Nitrogen Cycle

    Science.gov (United States)

    Galloway, J. N.

    2003-12-01

    Once upon a time nitrogen did not exist. Today it does. In the intervening time the universe was formed, nitrogen was created, the Earth came into existence, and its atmosphere and oceans were formed! In this analysis of the Earth's nitrogen cycle, I start with an overview of these important events relative to nitrogen and then move on to the more traditional analysis of the nitrogen cycle itself and the role of humans in its alteration.The universe is ˜15 Gyr old. Even after its formation, there was still a period when nitrogen did not exist. It took ˜300 thousand years after the big bang for the Universe to cool enough to create atoms; hydrogen and helium formed first. Nitrogen was formed in the stars through the process of nucleosynthesis. When a star's helium mass becomes great enough to reach the necessary pressure and temperature, helium begins to fuse into still heavier elements, including nitrogen.Approximately 10 Gyr elapsed before Earth was formed (˜4.5 Ga (billion years ago)) by the accumulation of pre-assembled materials in a multistage process. Assuming that N2 was the predominate nitrogen species in these materials and given that the temperature of space is -270 °C, N2 was probably a solid when the Earth was formed since its boiling point (b.p.) and melting point (m.p.) are -196 °C and -210 °C, respectively. Towards the end of the accumulation period, temperatures were probably high enough for significant melting of some of the accumulated material. The volcanic gases emitted by the resulting volcanism strongly influenced the surface environment. Nitrogen was converted from a solid to a gas and emitted as N2. Carbon and sulfur were probably emitted as CO and H2S (Holland, 1984). N2 is still the most common nitrogen volcanic gas emitted today at a rate of ˜2 TgN yr-1 (Jaffee, 1992).Once emitted, the gases either remained in the atmosphere or were deposited to the Earth's surface, thus continuing the process of biogeochemical cycling. The rate of

  4. Design principles of a conditional futile cycle exploited for regulation.

    Science.gov (United States)

    Tolla, Dean A; Kiley, Patricia J; Lomnitz, Jason G; Savageau, Michael A

    2015-07-01

    In this report, we characterize the design principles of futile cycling in providing rapid adaptation by regulatory proteins that act as environmental sensors. In contrast to the energetically wasteful futile cycles that are avoided in metabolic pathways, here we describe a conditional futile cycle exploited for a regulatory benefit. The FNR (fumarate and nitrate reduction) cycle in Escherichia coli operates under two regimes - a strictly futile cycle in the presence of O2 and as a pathway under anoxic conditions. The computational results presented here use FNR as a model system and provide evidence that cycling of this transcription factor and its labile sensory cofactor between active and inactive states affords rapid signaling and adaptation. We modify a previously developed mechanistic model to examine a family of FNR models each with different cycling speeds but mathematically constrained to be otherwise equivalent, and we identify a trade-off between energy expenditure and response time that can be tuned by evolution to optimize cycling rate of the FNR system for a particular ecological context. Simulations mimicking experiments with proposed double mutant strains offer suggestions for experimentally testing our predictions and identifying potential fitness effects. Our approach provides a computational framework for analyzing other conditional futile cycles, which when placed in their larger biological context may be found to confer advantages to the organism.

  5. Nuclear power and the nuclear fuel cycle

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1976-07-01

    The IAEA is organizing a major conference on nuclear power and the nuclear fuel cycle, which is to be held from 2 to 13 May 1977 in Salzburg, Austria. The programme for the conference was published in the preceding issue of the IAEA Bulletin (Vol.18, No. 3/4). Topics to be covered at the conference include: world energy supply and demand, supply of nuclear fuel and fuel cycle services, radioactivity management (including transport), nuclear safety, public acceptance of nuclear power, safeguarding of nuclear materials, and nuclear power prospects in developing countries. The articles in the section that follows are intended to serve as an introduction to the topics to be discussed at the Salzburg Conference. They deal with the demand for uranium and nuclear fuel cycle services, uranium supplies, a computer simulation of regional fuel cycle centres, nuclear safety codes, management of radioactive wastes, and a pioneering research project on factors that determine public attitudes toward nuclear power. It is planned to present additional background articles, including a review of the world nuclear fuel reprocessing situation and developments in the uranium enrichment industry, in future issues of the Bulletin. (author)

  6. Dynamic ubiquitin signaling in cell cycle regulation.

    Science.gov (United States)

    Gilberto, Samuel; Peter, Matthias

    2017-08-07

    The cell division cycle is driven by a collection of enzymes that coordinate DNA duplication and separation, ensuring that genomic information is faithfully and perpetually maintained. The activity of the effector proteins that perform and coordinate these biological processes oscillates by regulated expression and/or posttranslational modifications. Ubiquitylation is a cardinal cellular modification and is long known for driving cell cycle transitions. In this review, we emphasize emerging concepts of how ubiquitylation brings the necessary dynamicity and plasticity that underlie the processes of DNA replication and mitosis. New studies, often focusing on the regulation of chromosomal proteins like DNA polymerases or kinetochore kinases, are demonstrating that ubiquitylation is a versatile modification that can be used to fine-tune these cell cycle events, frequently through processes that do not involve proteasomal degradation. Understanding how the increasing variety of identified ubiquitin signals are transduced will allow us to develop a deeper mechanistic perception of how the multiple factors come together to faithfully propagate genomic information. Here, we discuss these and additional conceptual challenges that are currently under study toward understanding how ubiquitin governs cell cycle regulation. © 2017 Gilberto and Peter.

  7. US activities on fuel cycle transition scenarios

    International Nuclear Information System (INIS)

    McCarthy, Kathryn A.

    2010-01-01

    Countries with active nuclear programmes typically have as a goal transition to a closed fuel cycle. A closed fuel cycle enables long-term sustainability, provides waste management benefits, and as a system, can reduce overall proliferation risk. This transition will take many decades, thus the study of the actual transition is an important topic. The United States systems analysis activities as part of the Advanced Fuel Cycle Initiative (AFCI) provide the integrating analyses for the fuel cycle programme, and recent activities are focusing on transition options, and specifically, the dynamics of the transition. The United States is still studying both one-tier (recycling in fast reactors only) and two-tier (recycling in both thermal and fast reactors) systems, and the systems analysis activities provide insight into the trade-offs associated with the systems, and variations of each. Most recently, a series of sensitivity studies have been completed which provide insight into the behaviour of a transition system. These studies evaluate the impact of changing various parameters in the fuel cycle system, and provide insight into how the system will change as parameters change. Because these deployment analyses look at the development of nuclear energy systems over a long period of time, it is very unlikely that we will accurately predict the system's characteristics over time (for example, growth in electricity demand, how quickly nuclear reactors will be deployed, how many fast rectors versus thermal reactors, the conversion ratio of the fast reactors, etc.). How the system will develop will depend on a variety of factors, ranging from political to technical, rational to irrational. Because we cannot accurately predict the future, we need to understand how things could change, and what impact those changes have. Analyses of future fuel cycle systems require a number of assumptions. These include growth rates for nuclear energy, general architecture of fuel cycle

  8. Titan's Methane Cycle is Closed

    Science.gov (United States)

    Hofgartner, J. D.; Lunine, J. I.

    2013-12-01

    Doppler tracking of the Cassini spacecraft determined a polar moment of inertia for Titan of 0.34 (Iess et al., 2010, Science, 327, 1367). Assuming hydrostatic equilibrium, one interpretation is that Titan's silicate core is partially hydrated (Castillo-Rogez and Lunine, 2010, Geophys. Res. Lett., 37, L20205). These authors point out that for the core to have avoided complete thermal dehydration to the present day, at least 30% of the potassium content of Titan must have leached into an overlying water ocean by the end of the core overturn. We calculate that for probable ammonia compositions of Titan's ocean (compositions with greater than 1% ammonia by weight), that this amount of potassium leaching is achievable via the substitution of ammonium for potassium during the hydration epoch. Formation of a hydrous core early in Titan's history by serpentinization results in the loss of one hydrogen molecule for every hydrating water molecule. We calculate that complete serpentinization of Titan's core corresponds to the release of more than enough hydrogen to reconstitute all of the methane atoms photolyzed throughout Titan's history. Insertion of molecular hydrogen by double occupancy into crustal clathrates provides a storage medium and an opportunity for ethane to be converted back to methane slowly over time--potentially completing a cycle that extends the lifetime of methane in Titan's surface atmosphere system by factors of several to an order of magnitude over the photochemically-calculated lifetime.

  9. The life cycle of centrioles.

    Science.gov (United States)

    Hatch, E; Stearns, T

    2010-01-01

    Centrioles organize the centrosome and nucleate the ciliary axoneme, and the centriole life cycle has many parallels to the chromosome cycle. The centriole cycle in animals begins at fertilization with the contribution of two centrioles by the male gamete. In the ensuing cell cycles, the duplication of centrioles is controlled temporally, spatially, and numerically. As a consequence of the duplication mechanism, the two centrioles in a typical interphase cell are of different ages and have different functions. Here, we discuss how new centrioles are assembled, what mechanisms limit centriole number, and the consequences of the inherent asymmetry of centriole duplication and segregation.

  10. The nitrogen cycle.

    Science.gov (United States)

    Stein, Lisa Y; Klotz, Martin G

    2016-02-08

    Nitrogen is the fourth most abundant element in cellular biomass, and it comprises the majority of Earth's atmosphere. The interchange between inert dinitrogen gas (N2) in the extant atmosphere and 'reactive nitrogen' (those nitrogen compounds that support, or are products of, cellular metabolism and growth) is entirely controlled by microbial activities. This was not the case, however, in the primordial atmosphere, when abiotic reactions likely played a significant role in the inter-transformation of nitrogen oxides. Although such abiotic reactions are still important, the extant nitrogen cycle is driven by reductive fixation of dinitrogen and an enzyme inventory that facilitates dinitrogen-producing reactions. Prior to the advent of the Haber-Bosch process (the industrial fixation of N2 into ammonia, NH3) in 1909, nearly all of the reactive nitrogen in the biosphere was generated and recycled by microorganisms. Although the Haber-Bosch process more than quadrupled the productivity of agricultural crops, chemical fertilizers and other anthropogenic sources of fixed nitrogen now far exceed natural contributions, leading to unprecedented environmental degradation. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Biomass Gasification Combined Cycle

    Energy Technology Data Exchange (ETDEWEB)

    Judith A. Kieffer

    2000-07-01

    Gasification combined cycle continues to represent an important defining technology area for the forest products industry. The ''Forest Products Gasification Initiative'', organized under the Industry's Agenda 2020 technology vision and supported by the DOE ''Industries of the Future'' program, is well positioned to guide these technologies to commercial success within a five-to ten-year timeframe given supportive federal budgets and public policy. Commercial success will result in significant environmental and renewable energy goals that are shared by the Industry and the Nation. The Battelle/FERCO LIVG technology, which is the technology of choice for the application reported here, remains of high interest due to characteristics that make it well suited for integration with the infrastructure of a pulp production facility. The capital cost, operating economics and long-term demonstration of this technology area key input to future economically sustainable projects and must be verified by the 200 BDT/day demonstration facility currently operating in Burlington, Vermont. The New Bern application that was the initial objective of this project is not currently economically viable and will not be implemented at this time due to several changes at and around the mill which have occurred since the inception of the project in 1995. The analysis shows that for this technology, and likely other gasification technologies as well, the first few installations will require unique circumstances, or supportive public policies, or both to attract host sites and investors.

  12. The earth's hydrological cycle

    CERN Document Server

    Bonnet, R-M; Calisto, M; Destouni, G; Gurney, R; Johannessen, J; Kerr, Y; Lahoz, WA; Rast, M

    2014-01-01

    This book gives a comprehensive presentation of our present understanding of the Earth's Hydrological cycle and the problems, consequences and impacts that go with this topic. Water is a central component in the Earth's system. It is indispensable for life on Earth in its present form and influences virtually every aspect of our planet's life support system. On relatively short time scales, atmospheric water vapor interacts with the atmospheric circulation and is crucial in forming the Earth's climate zones. Water vapor is the most powerful of the greenhouse gases and serves to enhance the tropospheric temperature. The dominant part of available water on Earth resides in the oceans. Parts are locked up in the land ice on Greenland and Antarctica and a smaller part is estimated to exist as groundwater. If all the ice over the land and all the glaciers were to melt, the sea level would rise by some 80 m. In comparison, the total amount of water vapor in the atmosphere is small; it amounts to ~ 25 kg/m2, or the ...

  13. The thorium fuel cycle in water-moderated reactor systems

    International Nuclear Information System (INIS)

    Critoph, E.

    1977-01-01

    Current interest in the thorium cycle, as an alternative to the uranium cycle, for water-moderated reactors is based on two attractive aspects of its use - the extension of uranium resources, and the related lower sensitivity of energy costs to uranium price. While most of the scientific basis required is already available, some engineering demonstrations are needed to provide better economic data for rational decisions. Thorium and uranium cycles are compared with regard to reactor characteristics and technology, fuel-cycle technology, economic parameters, fuel-cycle costs, and system characteristics. There appear to be no major feasibility problems associated with the use of thorium, although development is required in the areas of fuel testing and fuel management. The use of thorium cycles implies recycling the fuel, and the major uncertainties are in the associated costs. Experience in the design and operation of fuel reprocessing and active-fabrication facilities is required to estimate costs to the accuracy needed for adequately defining the range of conditions economically favourable to thorium cycles. In heavy-water reactors (HWRs) thorium cycles having uranium requirements at equilibrium ranging from zero to a quarter of those for the natural-uranium once-through cycle appear feasible. An ''inventory'' of uranium of between 1 and 2Mg/MW(e) is required for the transition to equilibrium. The cycles with the lowest uranium requirements compete with the others only at high uranium prices. Using thorium in light-water reactors, uranium requirements can be reduced by a factor of between two and three from the once-through uranium cycle. The light-water breeder reactor, promising zero uranium requirements at equilibrium, is being developed. Larger uranium inventories are required than for the HWRs. The lead time, from a decision to use thorium to significant impact on uranium utilization (compared to uranium cycle, recycling plutonium), is some two decades

  14. Life-cycle cost analysis of adsorption cycles for desalination

    KAUST Repository

    Thu, Kyaw; Chakraborty, A.; Saha, B.B.; Chun, Won Gee; Ng, K.C.

    2010-01-01

    This paper presents the thermo-economic analysis of the adsorption desalination (AD) cycle that is driven by low-temperature waste heat from exhaust of industrial processes or renewable sources. The AD cycle uses an adsorbent such as the silica gel

  15. 'Benefits cycle' replacing premium cycle as consumerism takes hold.

    Science.gov (United States)

    2002-05-01

    The traditional premium cycle of ups and downs in rates is giving way to a new phenomenon--driven by the advent of consumerism in health care--termed the "benefits cycle" by one consultant. Rather than shifts in rates, he argues, the future will see shifts in benefits packages.

  16. Future fuel cycle and reactor strategies

    International Nuclear Information System (INIS)

    Meneley, D.A.

    1999-01-01

    Within the framework of the 1997 IAEA Symposium 'Future Fuel Cycle and Reactor Strategies Adjusting to New Realities', Working Group No.3 produced a Key Issues paper addressing the title of the symposium. The scope of the Key Issues paper included those factors that are expected to remain or become important in the time period from 2015 to 2050, considering all facets of nuclear energy utilization from ore extraction to final disposal of waste products. The paper addressed the factors influencing the choice of reactor and fuel cycle. It then addressed the quantitatively largest category of reactor types expected to be important during the period; that is, thermal reactors burning uranium and plutonium fuel. The fast reactor then was discussed both as a stand-alone technology and as might be used in combination with thermal reactors. Thorium fuel use was discussed briefly. The present paper includes of a digest of the Key Issues Paper. Some comparisons arc made between the directions suggested in that paper and those indicated by the Abstracts of this Technical Committee Meeting- Recommendations are made for work which might be undertaken in the short and medium time frames, to ensure that fuel cycle technologies and processes established by the year 2050 will support the continuation of nuclear energy applications in the long term. (author)

  17. Influence of service life on Life Cycle Assessments

    NARCIS (Netherlands)

    van Nunen, H.; Hendriks, N.A.; Erkelens, P.A.

    2003-01-01

    Environmental assessment is part of present decision making. But, because of difficulties the assessments are not as profound as could be. Life Cycle Assessment (LCA) is a cradle-to-grave approach and consequently a time factor is embedded. Until now this time factor is fixed and calculations are

  18. Evaluation of effects of different fuel cycles in environment

    International Nuclear Information System (INIS)

    1979-03-01

    The paper discusses the risks for personnel and environment caused by different steps of FBR-Fuel cycle. For FBRS the most important factor of exposure is the fabrication of fuel elements but technical development is capable to reduce this factor

  19. Survey of nuclear fuel cycle economics: 1970--1985

    International Nuclear Information System (INIS)

    Prince, B.E.; Peerenboom, J.P.; Delene, J.G.

    1977-03-01

    This report is intended to provide a coherent view of the diversity of factors that may affect nuclear fuel cycle economics through about 1985. The nuclear fuel cycle was surveyed as to past trends, current problems, and future considerations. Unit costs were projected for each step in the fuel cycle. Nuclear fuel accounting procedures were reviewed; methods of calculating fuel costs were examined; and application was made to Light Water Reactors (LWR) over the next decade. A method conforming to Federal Power Commission accounting procedures and used by utilities to account for backend fuel-cycle costs was described which assigns a zero net salvage value to discharged fuel. LWR fuel cycle costs of from 4 to 6 mills/kWhr (1976 dollars) were estimated for 1985. These are expected to reach 6 to 9 mills/kWr if the effect of inflation is included

  20. Life Cycle Assessment for Biofuels

    Science.gov (United States)

    A presentation based on life cycle assessment (LCA) for biofuels is given. The presentation focuses on energy and biofuels, interesting environmental aspects of biofuels, and how to do a life cycle assessment with some examples related to biofuel systems. The stages of a (biofuel...

  1. Hamiltonian cycles in polyhedral maps

    Indian Academy of Sciences (India)

    We present a necessary and sufficient condition for existence of a contractible, non-separating and non-contractible separating Hamiltonian cycle in the edge graph of polyhedral maps on surfaces.We also present algorithms to construct such cycles whenever it exists where one of them is linear time and another is ...

  2. Emissions from photovoltaic life cycles

    NARCIS (Netherlands)

    Fthenakis, V.M.; Kim, H.C.; Alsema, E.A.|info:eu-repo/dai/nl/073416258

    2008-01-01

    Photovoltaic (PV) technologies have shown remarkable progress recently in terms of annual production capacity and life cycle environmental performances, which necessitate timely updates of environmental indicators. Based on PV production data of 2004–2006, this study presents the life-cycle

  3. Drought and ecosystem carbon cycling

    NARCIS (Netherlands)

    Molen, M.K. van der; Dolman, A.J.; Ciais, P.; Eglin, T.; Gobron, N.; Law, B.E.; Meir, P.; Peters, P.; Philips, O.L.; Reichstein, M.; Chen, T.; Dekker, S.C.; Doubkova, M.; Friedl, M.A.; Jung, M.; Hurk, B.J.J.M. van den; Jeu, R.A.M. de; Kruijt, B.; Ohta, T.; Rebel, K.T.; Plummer, S.; Seneviratne, S.I.; Sitch, S.; Teuling, A.J.; Werf, G.R. van der; Wang, G.

    2011-01-01

    Drought as an intermittent disturbance of the water cycle interacts with the carbon cycle differently than the ‘gradual’ climate change. During drought plants respond physiologically and structurally to prevent excessive water loss according to species-specific water use strategies. This has

  4. Economic growth and business cycles

    NARCIS (Netherlands)

    Canton, E.J.F.

    1997-01-01

    This thesis contains five essays on economic growth and business cycles. The main focus is on the interaction between economic growth and the cycle: is cyclical variability good or bad for the long-run rate of economic growth? The introduction aims to provide some empirical evidence for an

  5. Variations on the Zilch Cycle

    Science.gov (United States)

    Binder, P.-M.; Tanoue, C. K. S.

    2013-01-01

    Thermo dynamic cycles in introductory physics courses are usually made up from a small number of permutations of isothermal, adiabatic, and constant-pressure and volume quasistatic strokes, with the working fluid usually being an ideal gas. Among them we find the Carnot, Stirling, Otto, Diesel, and Joule-Brayton cycles; in more advanced courses,…

  6. Quadratic reactivity fuel cycle model

    International Nuclear Information System (INIS)

    Lewins, J.D.

    1985-01-01

    For educational purposes it is highly desirable to provide simple yet realistic models for fuel cycle and fuel economy. In particular, a lumped model without recourse to detailed spatial calculations would be very helpful in providing the student with a proper understanding of the purposes of fuel cycle calculations. A teaching model for fuel cycle studies based on a lumped model assuming the summability of partial reactivities with a linear dependence of reactivity usefully illustrates fuel utilization concepts. The linear burnup model does not satisfactorily represent natural enrichment reactors. A better model, showing the trend of initial plutonium production before subsequent fuel burnup and fission product generation, is a quadratic fit. The study of M-batch cycles, reloading 1/Mth of the core at end of cycle, is now complicated by nonlinear equations. A complete account of the asymptotic cycle for any order of M-batch refueling can be given and compared with the linear model. A complete account of the transient cycle can be obtained readily in the two-batch model and this exact solution would be useful in verifying numerical marching models. It is convenient to treat the parabolic fit rho = 1 - tau 2 as a special case of the general quadratic fit rho = 1 - C/sub tau/ - (1 - C)tau 2 in suitably normalized reactivity and cycle time units. The parabolic results are given in this paper

  7. National Urea Cycle Disorders Foundation

    Science.gov (United States)

    ... urea cycle disorders. Donate Now To End Urea Cycle Disorders © 2005-2017 NUCDF. All rights reserved. This site may be freely linked to but not copied or duplicated in any fashion without the Foundation's consent. Make A Donation in ...

  8. The water cycle for kids

    Science.gov (United States)

    Neno, Stephanie; Morgan, Jim; Zonolli, Gabriele; Perlman, Howard; Gonthier, Gerard

    2013-01-01

    The U.S. Geological Survey (USGS) and the Food and Agriculture Organization of the United Nations (FAO) have created a water-cycle diagram for use in elementary and middle schools. The diagram is available in many languages. This diagram is part of the USGS's Water Science School, in which the water cycle is described in detail.

  9. Credit cycles and macro fundamentals

    NARCIS (Netherlands)

    Koopman, S.J.; Kraeussl, R.G.W.; Lucas, A.; Monteiro, A.

    2009-01-01

    We use an intensity-based framework to study the relation between macroeconomic fundamentals and cycles in defaults and rating activity. Using Standard and Poor's U.S. corporate rating transition and default data over the period 1980-2005, we directly estimate the default and rating cycle from micro

  10. Nuclear fuel cycle information workshop

    International Nuclear Information System (INIS)

    1983-01-01

    This overview of the nuclear fuel cycle is divided into three parts. First, is a brief discussion of the basic principles of how nuclear reactors work; second, is a look at the major types of nuclear reactors being used and world-wide nuclear capacity; and third, is an overview of the nuclear fuel cycle and the present industrial capability in the US

  11. Ecological effects on arbovirus-mosquito cycles of transmission.

    Science.gov (United States)

    Tabachnick, Walter J

    2016-12-01

    Mosquitoes transmit many viruses to a variety of hosts. Cycles of mosquito borne arbovirus transmission are the result of complex interactions between the mosquito, the arbovirus and the host that are influenced by genetic variations in a variety of traits in each that are all influenced by many environmental factors. R 0 , the basic reproduction number or mean number of individuals infected from a single infected individual, is a measure of mosquito borne arbovirus transmission. Understanding the causes for the distribution of R 0 in any transmission cycle is a daunting challenge due to the lack of information on the genetic and environmental variances that influence R 0 . Information about the major factors influencing R 0 for specific transmission cycles is essential to develop efficient and effective strategies to reduce transmission in different cycles and locations. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Low cycle fatigue: high cycle fatigue damage accumulation in a 304L austenitic stainless steel

    International Nuclear Information System (INIS)

    Lehericy, Y.

    2007-05-01

    The aim of this study was to evaluate the consequences of a Low Cycle Fatigue pre-damage on the subsequent fatigue limit of a 304L stainless steel. The effects of hardening and severe roughness (grinding) have also been investigated. In a first set of tests, the evolution of the surface damage induced by the different LCF pre-cycling was characterized. This has permitted to identify mechanisms and kinetics of damage in the plastic domain for different surface conditions. Then, pre-damaged samples were tested in the High Cycle Fatigue domain in order to establish the fatigue limits associated with each level of pre-damage. Results evidence that, in the case of polished samples, an important number of cycles is required to initiate surface cracks ant then to affect the fatigue limit of the material but, in the case of ground samples, a few number of cycles is sufficient to initiate cracks and to critically decrease the fatigue limit. The fatigue limit of pre-damaged samples can be estimated using the stress intensity factor threshold. Moreover, this detrimental effect of severe surface conditions is enhanced when fatigue tests are performed under a positive mean stress (author)

  13. Adolescent pregnancy: intervention into the poverty cycle.

    Science.gov (United States)

    Johnson, C L

    1974-01-01

    Adolescent pregnancy, irrespective of the marital status of the mother, seems to be a determining factor in the incidence of female headed households, divorce, excessive fertility, and poverty. In addition, the pregnant teenager is, obstetrically, a high risk patient, and her offspring, due to poor prenatal care and inadequate nutrition on the part of the mother, is likely to suffer in terms of physical and mental development. This in turn will lead to further poverty, which will continue the cycle. One way to interrupt the cycle may be by delaying the first birth to young adolescent girls. There are 3 stages at which prevention can take place: preventing intercourse, preventing conception, and terminating pregnancy. For the teenager, preventing conception seems the most feasible. Effforts to design family planning programs especially for teenager should be expanded. By this, 2 generation can benefit: the teenager herself and her potential offspring.

  14. Solar cycle variations in mesospheric carbon monoxide

    Science.gov (United States)

    Lee, Jae N.; Wu, Dong L.; Ruzmaikin, Alexander; Fontenla, Juan

    2018-05-01

    As an extension of Lee et al. (2013), solar cycle variation of carbon monoxide (CO) is analyzed with MLS observation, which covers more than thirteen years (2004-2017) including maximum of solar cycle 24. Being produced primarily by the carbon dioxide (CO2) photolysis in the lower thermosphere, the variations of the mesospheric CO concentration are largely driven by the solar cycle modulated ultraviolet (UV) variation. This solar signal extends down to the lower altitudes by the dynamical descent in the winter polar vortex, showing a time lag that is consistent with the average descent velocity. To characterize a global distribution of the solar impact, MLS CO is correlated with the SORCE measured total solar irradiance (TSI) and UV. As high as 0.8 in most of the polar mesosphere, the linear correlation coefficients between CO and UV/TSI are more robust than those found in the previous work. The photochemical contribution explains most (68%) of the total variance of CO while the dynamical contribution accounts for 21% of the total variance at upper mesosphere. The photochemistry driven CO anomaly signal is extended in the tropics by vertical mixing. The solar cycle signal in CO is further examined with the Whole Atmosphere Community Climate Model (WACCM) 3.5 simulation by implementing two different modeled Spectral Solar Irradiances (SSIs): SRPM 2012 and NRLSSI. The model simulations underestimate the mean CO amount and solar cycle variations of CO, by a factor of 3, compared to those obtained from MLS observation. Different inputs of the solar spectrum have small impacts on CO variation.

  15. Analysis of possible fuel cycles

    International Nuclear Information System (INIS)

    Boehm, H.; Kessler, G.; Engelmann, P.; Maerkl, H.; Stoll, W.

    1978-01-01

    A brief survey is presented of the most important fuel cycles. A rough analysis of fuel cycles is attempted under the aspects of proliferation, status of technical feasibility, resource conservation and waste management and the most important criteria for such an analysis are discussed. Among the multitude of potential combinations of fuel cycles and types of reactors only a few have reached a level of technical feasibility which would make them eligible for commercial implementation within the next decade. However, if, for instance, the higher proliferation resistance of a specific fuel cycle is to be utilized to diminish the worldwide proliferation hazard, that cycle would first of all have to be introduced on an industrial scale as quickly as possible. The analysis shows that the reduction of the bazard of worldwide proliferation will continue to be the objective primarily of international agreements and measures taken in the political realm. (orig.) [de

  16. Fuel cycle optimization in PWR'S

    International Nuclear Information System (INIS)

    Castro Lobo, P.D. de; Amorim, E.S. do.

    1979-08-01

    Neutronics aspects of a reactor core throughout its cycle were investigated in a search for increasing in-core utilization of the residual fissile isotopes content in the cycle discharged disposal. The effects due to design modifications introduced at burnup levels near the end-of-cycle, in an equilibrium cycle condition, have indicated the possibility of a better in-core utilization of the residual fissile isotopes existing in the cycle discharged disposal. The potential benefits are significant to warranty an examination of the mechanical and thermal hydraulic involved. At convenient burnup levels, change in H 2 O/UO 2 volume ratio were introduced allowing an intense depletion of the residual fissile isotopes existing in assemblies with high exposures levels. (Author) [pt

  17. Fuel cycle cost uncertainty from nuclear fuel cycle comparison

    International Nuclear Information System (INIS)

    Li, J.; McNelis, D.; Yim, M.S.

    2013-01-01

    This paper examined the uncertainty in fuel cycle cost (FCC) calculation by considering both model and parameter uncertainty. Four different fuel cycle options were compared in the analysis including the once-through cycle (OT), the DUPIC cycle, the MOX cycle and a closed fuel cycle with fast reactors (FR). The model uncertainty was addressed by using three different FCC modeling approaches with and without the time value of money consideration. The relative ratios of FCC in comparison to OT did not change much by using different modeling approaches. This observation was consistent with the results of the sensitivity study for the discount rate. Two different sets of data with uncertainty range of unit costs were used to address the parameter uncertainty of the FCC calculation. The sensitivity study showed that the dominating contributor to the total variance of FCC is the uranium price. In general, the FCC of OT was found to be the lowest followed by FR, MOX, and DUPIC. But depending on the uranium price, the FR cycle was found to have lower FCC over OT. The reprocessing cost was also found to have a major impact on FCC

  18. Climate impacts of bioenergy: Inclusion of carbon cycle and albedo dynamics in life cycle impact assessment

    International Nuclear Information System (INIS)

    Bright, Ryan M.; Cherubini, Francesco; Strømman, Anders H.

    2012-01-01

    Life cycle assessment (LCA) can be an invaluable tool for the structured environmental impact assessment of bioenergy product systems. However, the methodology's static temporal and spatial scope combined with its restriction to emission-based metrics in life cycle impact assessment (LCIA) inhibits its effectiveness at assessing climate change impacts that stem from dynamic land surface–atmosphere interactions inherent to all biomass-based product systems. In this paper, we focus on two dynamic issues related to anthropogenic land use that can significantly influence the climate impacts of bioenergy systems: i) temporary changes to the terrestrial carbon cycle; and ii) temporary changes in land surface albedo—and illustrate how they can be integrated within the LCA framework. In the context of active land use management for bioenergy, we discuss these dynamics and their relevancy and outline the methodological steps that would be required to derive case-specific biogenic CO 2 and albedo change characterization factors for inclusion in LCIA. We demonstrate our concepts and metrics with application to a case study of transportation biofuel sourced from managed boreal forest biomass in northern Europe. We derive GWP indices for three land management cases of varying site productivities to illustrate the importance and need to consider case- or region-specific characterization factors for bioenergy product systems. Uncertainties and limitations of the proposed metrics are discussed. - Highlights: ► A method for including temporary surface albedo and carbon cycle changes in Life Cycle Impact Assessment (LCIA) is elaborated. ► Concepts are applied to a single bioenergy case whereby a range of feedstock productivities are shown to influence results. ► Results imply that case- and site-specific characterization factors can be essential for a more informed impact assessment. ► Uncertainties and limitations of the proposed methodologies are elaborated.

  19. Financing Strategies for Nuclear Fuel Cycle Facility

    International Nuclear Information System (INIS)

    David Shropshire; Sharon Chandler

    2005-01-01

    To help meet our nation's energy needs, reprocessing of spent nuclear fuel is being considered more and more as a necessary step in a future nuclear fuel cycle, but incorporating this step into the fuel cycle will require considerable investment. This report presents an evaluation of financing scenarios for reprocessing facilities integrated into the nuclear fuel cycle. A range of options, from fully government owned to fully private owned, was evaluated using a DPL (Dynamic Programming Language) 6.0 model, which can systematically optimize outcomes based on user-defined criteria (e.g., lowest life-cycle cost, lowest unit cost). Though all business decisions follow similar logic with regard to financing, reprocessing facilities are an exception due to the range of financing options available. The evaluation concludes that lowest unit costs and lifetime costs follow a fully government-owned financing strategy, due to government forgiveness of debt as sunk costs. Other financing arrangements, however, including regulated utility ownership and a hybrid ownership scheme, led to acceptable costs, below the Nuclear Energy Agency published estimates. Overwhelmingly, uncertainty in annual capacity led to the greatest fluctuations in unit costs necessary for recovery of operating and capital expenditures; the ability to determine annual capacity will be a driving factor in setting unit costs. For private ventures, the costs of capital, especially equity interest rates, dominate the balance sheet; the annual operating costs dominate the government case. It is concluded that to finance the construction and operation of such a facility without government ownership could be feasible with measures taken to mitigate risk, and that factors besides unit costs should be considered (e.g., legal issues, social effects, proliferation concerns) before making a decision on financing strategy

  20. The role of neprilysin in regulating the hair cycle.

    Directory of Open Access Journals (Sweden)

    Naoko Morisaki

    Full Text Available In most mammals, each hair follicle undergoes a cyclic process of growing, regressing and resting phases (anagen, catagen, telogen, respectively called the hair cycle. Various biological factors have been reported to regulate or to synchronize with the hair cycle. Some factors involved in the extracellular matrix, which is a major component of skin tissue, are also thought to regulate the hair cycle. We have focused on an enzyme that degrades elastin, which is associated with skin elasticity. Since our previous study identified skin fibroblast elastase as neprilysin (NEP, we examined the fluctuation of NEP enzyme activity and its expression during the synchronized hair cycle of rats. NEP activity in the skin was elevated at early anagen, and decreased during catagen to telogen. The expression of NEP mRNA and protein levels was modulated similarly. Immunostaining showed changes in NEP localization throughout the hair cycle, from the follicular epithelium during early anagen to the dermal papilla during catagen. To determine whether NEP plays an important role in regulating the hair cycle, we used a specific inhibitor of NEP (NPLT. NPLT was applied topically daily to the dorsal skin of C3H mice, which had been depilated in advance. Mice treated with NPLT had significantly suppressed hair growth. These data suggest that NEP plays an important role in regulating the hair cycle by its increased expression and activity in the follicular epithelium during early anagen.

  1. Designer and constructor practices to ensure life cycle performance.

    OpenAIRE

    Shelton, Joelle L.

    1998-01-01

    CIVINS (Civilian Institutions) Thesis document Technology advances of the last few decades, in such areas as computing and construction materials, have inspired many attempts to improve the construction process. Many of these attempts focus on reducing costs and improving functionality, such as life cycle cost analysis and value engineering, while others, such as design-build, focus on specific phases of the life cycle. Other factors such as declining productivity, the quantity of construc...

  2. Transportation of radioactive wastes from nuclear fuel cycles

    International Nuclear Information System (INIS)

    1979-09-01

    This paper discusses current and foreseen radioactive waste transportation systems as they apply to the INFCE Working Group 7 study. The types of wastes considered include spent fuel, which is treated as a waste in once-through fuel cycles; high-, medium-, and low-level waste; and gaseous waste. Regulatory classification of waste quantities and containers applicable to these classifications are discussed. Radioactive wastes are presently being transported in a safe and satisfactory manner. None of the INFCE candidate fuel cycles pose any extraordinary problems to future radioactive waste transportation and such transportation will not constitute a decisive factor in the choice of a preferred fuel cycle

  3. Out-of-core fuel cycle optimization for nonequilibrium cycles

    International Nuclear Information System (INIS)

    Comes, S.A.; Turinsky, P.J.

    1988-01-01

    A methodology has been developed for determining the family of near-optimum fuel management schemes that minimize the levelized fuel cycle costs of a light water reactor over a multicycle planning horizon. Feed batch enrichments and sizes, burned batches to reinsert, and burnable poison loadings are determined for each cycle in the planning horizon. Flexibility in the methodology includes the capability to assess the economic benefits of various partially burned bath reload strategies as well as the effects of using split feed enrichments and enrichment palettes. Constraint limitations are imposed on feed enrichments, discharge burnups, moderator temperature coefficient, and cycle energy requirements

  4. The thorium fuel cycle in water-moderated reactor systems

    International Nuclear Information System (INIS)

    Critoph, E.

    1977-05-01

    Thorium and uranium cycles are compared with regard to reactor characteristics and technology, fuel-cycle technology, economic parameters, fuel-cycle costs, and system characteristics. In heavy-water reactors (HWRs) thorium cycles having uranium requirements at equilibrium ranging from zero to a quarter of those for the natural-uranium once-through cycle appear feasible. An 'inventory' of uranium of between 1 and 2 Mg/MW(e) is required for the transition to equilibrium. The cycles with the lowest uranium requirements compete with the others only at high uranium prices. Using thorium in light-water reactors, uranium requirements can be reduced by a factor of between two and three from the once-through uranium cycle. The light-water breeder reactor, promising zero uranium requirements at equilibrium, is being developed. Larger uranium inventories are required than for the HWRs. The lead time, from a decision to use thorium to significant impact on uranium utilization (compared to uranium cycle, recycling plutonium) is some two decades

  5. Methodologies for evaluating the proliferation resistance of nuclear fuel cycles

    International Nuclear Information System (INIS)

    Shiotani, Hiroki; Hori, Kei-ichiro; Takeda, Hiroshi

    2001-01-01

    The Japan Nuclear Cycle Development Institute (JNC) believes that the development of future nuclear fuel cycle technology should be conducted with careful consideration given to non-proliferation. JNC is studying methodologies for evaluating proliferation resistance of nuclear fuel cycle technologies. However, it is difficult to establish the methodology for evaluating proliferation resistance since the results greatly depend on the assumption for the evaluation and the surrounding conditions. This study grouped factors of proliferation resistance into categories through reviewing past studies and studied the relationships between the factors. Then, this study tried to find vulnerable nuclear material (plutonium) in some FBR fuel cycles from the proliferation perspective, and calculated the time it takes to convert the materials from various nuclear fuel cycles into pure plutonium metal under some assumptions. The result showed that it would take a long time to convert the nuclear materials from the FBR fuel cycles without plutonium separation. While it is a preliminary attempt to evaluate a technical factor of proliferation resistance as the basis of the institutional proliferation resistance, the JNC hopes that it will contribute to future discussions in this area. (author)

  6. Cycling biomechanics: a literature review.

    Science.gov (United States)

    Wozniak Timmer, C A

    1991-01-01

    Submitted in partial fulfillment for a Master of Science degree at the University of Pittsburgh, School of Health Related Professions, Pittsburgh, PA 1.5213 This review of current literature on cycling biomechanics emphasizes lower extremity muscle actions and joint excursions, seat height, pedal position, pedaling rate, force application, and pedaling symmetry. Guidelines are discussed for optimal seat height, pedal position, and pedaling rate. Force application in the power and recovery phases of cycling and the relationship of force application to pedaling symmetry are discussed. The need for a biomechanical approach to cycling exists since a great deal of the literature is primarily physiologic in nature. The purpose of this review is to make cyclists and their advisors aware of the biomechanics of cycling and guidelines to follow. This approach is also important because cycling is a very common form of exercise prescribed by physical therapists for clinic or home programs. Biomechanical aspects of cycling should be considered by cyclists at any level of participation and by physical therapists in order for goal-oriented, efficient cycling to occur. J Orthop Sports Phys Ther 1991;14(3):106-113.

  7. Cell Cycle Control by PTEN.

    Science.gov (United States)

    Brandmaier, Andrew; Hou, Sheng-Qi; Shen, Wen H

    2017-07-21

    Continuous and error-free chromosome inheritance through the cell cycle is essential for genomic stability and tumor suppression. However, accumulation of aberrant genetic materials often causes the cell cycle to go awry, leading to malignant transformation. In response to genotoxic stress, cells employ diverse adaptive mechanisms to halt or exit the cell cycle temporarily or permanently. The intrinsic machinery of cycling, resting, and exiting shapes the cellular response to extrinsic stimuli, whereas prevalent disruption of the cell cycle machinery in tumor cells often confers resistance to anticancer therapy. Phosphatase and tensin homolog (PTEN) is a tumor suppressor and a guardian of the genome that is frequently mutated or deleted in human cancer. Moreover, it is increasingly evident that PTEN deficiency disrupts the fundamental processes of genetic transmission. Cells lacking PTEN exhibit cell cycle deregulation and cell fate reprogramming. Here, we review the role of PTEN in regulating the key processes in and out of cell cycle to optimize genomic integrity. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. When Product Life Cycle Meets Customer Activity Cycle

    DEFF Research Database (Denmark)

    Tan, Adrian Ronald

    2007-01-01

    Manufacturing companies have traditionally focused their efforts on designing, developing and producing products to offer on the market. Today global competition and demands for greater company responsibility of products throughout their entire life cycle are driving manufacturing companies to sh...

  9. Fuel cycle economics of HTRs

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, U.

    1975-06-15

    The High Temperature Reactor commands a unique fuel cycle flexibility and alternative options are open to the utilities. The reference thorium reactor operating in the U-233 recycle mode is 10 to 20% cheaper than the low-enriched reactor; however, the thorium cycle depends on the supply of 93% enriched uranium and the availability of reprocessing and refabrication facilities to utilize its bred fissile material. The economic landscape towards the end of the 20th Century will presumably be dominated by pronounced increases in the costs of natural resources. In the case of nuclear energy, resource considerations are reflected in the price of uranium, which is expected Lo have reached 50 $/lbm U3O8 in the early 1990s and around 100 $/lbm U3O8 around 2010. In this economic environment the fuel cycle advantage of the thorium system amounts to some 20% and is capable of absorbing substantial expenses in bringing about the closing of the out-of-pile cycle. A most attractive aspect of the HTR fuel cycle flexibility is for the utility to start operating the reactor on the low enriched uranium cycle and at a later date switch over to the thorium cycle as this becomes economically more and more attractive. The incentive amounts to some 50 M$ in terms of present worth money at the time of decision making, assumed to take place 10 years after start-up. The closing of the thorium cycle is of paramount importance and a step to realize this objective lies in simplifying the head-end reprocessing technology by abandoning the segregation concept of feed and breed coated particles in the reference cycle. A one-coated-particle scheme in which all discharged uranium isotopes are recycled in mixed oxide particles is feasible and suffers a very minor economic penalty only.

  10. Understanding and encouraging cycle commuting in workplace setting: a psychological perspective

    OpenAIRE

    Van Bekkum, Jennifer Elizabeth

    2011-01-01

    This thesis considers the roles that social cognitions play in cycle commuting behaviour. Currently in the field of active travel there is a strong drive towards ecological theories, which often focus on the wider environmental factors that influence cycling. However, research into utilitarian cycling and related physical activities suggests that psychological factors also have an important role to play. In light of the current political climate within the UK and the numerous b...

  11. Specific features of high-cycle and ultra-high-cycle fatigue

    Czech Academy of Sciences Publication Activity Database

    Lukáš, Petr; Kunz, Ludvík

    2002-01-01

    Roč. 25, - (2002), s. 747-753 ISSN 8756-758X R&D Projects: GA AV ČR KSK1010104; GA AV ČR IAA2041002 Institutional research plan: CEZ:AV0Z2041904 Keywords : ultra high cycle fatigue * fatigue mechanisms * cyclic plastic deformation Subject RIV: JL - Materials Fatigue, Friction Mechanics Impact factor: 0.701, year: 2002

  12. Introducing Life Cycle Impact Assessment

    DEFF Research Database (Denmark)

    Hauschild, Michael Zwicky; Huijbregts, Mark AJ

    2015-01-01

    This chapter serves as an introduction to the presentation of the many aspects of life cycle impact assessment (LCIA) in this volume of the book series ‘LCA Compendium’. It starts with a brief historical overview of the development of life cycle impact assessment driven by numerous national LCIA...... methodology projects and presents the international scientific discussions and methodological consensus attempts in consecutive working groups under the auspices of the Society of Environmental Toxicology and Chemistry (SETAC) as well as the UNEP/ SETAC Life Cycle Initiative, and the (almost) parallel...

  13. The fuel cycle scoping system

    International Nuclear Information System (INIS)

    Dooley, G.D.; Malone, J.P.

    1986-01-01

    The Fuel Cycle Scoping System (FCSS) was created to fill the need for a scoping tool which provides the utilities with the ability to quickly evaluate alternative fuel management strategies, tails assay choices, fuel fabrication quotes, fuel financing alternatives, fuel cycle schedules, and other fuel cycle perturbations. The FCSS was specifically designed for PC's that support dBASE-III(TM), a relational data base software system by Ashton-Tate. However, knowledge of dBASE-III is not necessary in order to utilize the FCSS. The FCSS is menu driven and can be utilized as a teaching tool as well as a scoping tool

  14. Digital daily cycles of individuals

    DEFF Research Database (Denmark)

    Aledavood, Talayeh; Jørgensen, Sune Lehmann; Saramäki, Jari

    2015-01-01

    Humans, like almost all animals, are phase-locked to the diurnal cycle. Most of us sleep at night and are active through the day. Because we have evolved to function with this cycle, the circadian rhythm is deeply ingrained and even detectable at the biochemical level. However, within the broader...... day-night pattern, there are individual differences: e.g., some of us are intrinsically morning-active, while others prefer evenings. In this article, we look at digital daily cycles: circadian patterns of activity viewed through the lens of auto-recorded data of communication and online activity. We...

  15. Solar cycles and climate variations

    International Nuclear Information System (INIS)

    Chistyakov, V.F.

    1990-01-01

    Climate oscillations with 100-, 200- and 300-year periods are positively correlated with solar activity oscillations: the higher is solar activity the warmer is climate. According to geological data (varved clays) it is determined, that length of cycles has decreased from 23.4 up to 11 years during latter 2.5 billion years. 12-year cycles occurred during the great glaciation periods, while 10-year cycles occurred during interglaciation periods. It is suggested, that these oscillations are related with variations of the solar activity and luminescence

  16. BWROPT: A multi-cycle BWR fuel cycle optimization code

    Energy Technology Data Exchange (ETDEWEB)

    Ottinger, Keith E.; Maldonado, G. Ivan, E-mail: Ivan.Maldonado@utk.edu

    2015-09-15

    Highlights: • A multi-cycle BWR fuel cycle optimization algorithm is presented. • New fuel inventory and core loading pattern determination. • The parallel simulated annealing algorithm was used for the optimization. • Variable sampling probabilities were compared to constant sampling probabilities. - Abstract: A new computer code for performing BWR in-core and out-of-core fuel cycle optimization for multiple cycles simultaneously has been developed. Parallel simulated annealing (PSA) is used to optimize the new fuel inventory and placement of new and reload fuel for each cycle considered. Several algorithm improvements were implemented and evaluated. The most significant of these are variable sampling probabilities and sampling new fuel types from an ordered array. A heuristic control rod pattern (CRP) search algorithm was also implemented, which is useful for single CRP determinations, however, this feature requires significant computational resources and is currently not practical for use in a full multi-cycle optimization. The PSA algorithm was demonstrated to be capable of significant objective function reduction and finding candidate loading patterns without constraint violations. The use of variable sampling probabilities was shown to reduce runtime while producing better results compared to using constant sampling probabilities. Sampling new fuel types from an ordered array was shown to have a mixed effect compared to random new fuel type sampling, whereby using both random and ordered sampling produced better results but required longer runtimes.

  17. Life-cycle cost analysis of adsorption cycles for desalination

    KAUST Repository

    Thu, Kyaw

    2010-08-01

    This paper presents the thermo-economic analysis of the adsorption desalination (AD) cycle that is driven by low-temperature waste heat from exhaust of industrial processes or renewable sources. The AD cycle uses an adsorbent such as the silica gel to desalt the sea or brackish water. Based on an experimental prototype AD plant, the life-cycle cost analysis of AD plants of assorted water production capacities has been simulated and these predictions are translated into unit cost of water production. Our results show that the specific energy consumption of the AD cycle is 1.38 kWh/m3 which is the lowest ever reported. For a plant capacity of 1000 m3/d, the AD cycle offers a unit cost of $0.457/m3 as compared to more than $0.9 for the average RO plants. Besides being cost-effective, the AD cycle is also environment-friendly as it emits less CO2 emission per m3 generated, typically 85% less, by comparison to an RO process. © 2010 Desalination Publications.

  18. A study on different thermodynamic cycle schemes coupled with a high temperature gas-cooled reactor

    International Nuclear Information System (INIS)

    Qu, Xinhe; Yang, Xiaoyong; Wang, Jie

    2017-01-01

    Highlights: • The features of three different power generation schemes, including closed Brayton cycle, non-reheating combined cycle and reheating combined cycle, coupled with high temperature gas-cooled reactor (HTGR) were investigated and compared. • The effects and mechanism of reactor core outlet temperature, compression ratio and other key parameters over cycle characteristics were analyzed by the thermodynamic models.. • It is found that reheated combined cycle has the highest efficiency. Reactor outlet temperature and main steam parameters are key factors to improve the cycle’s performance. - Abstract: With gradual increase in reactor outlet temperature, the efficient power conversion technology has become one of developing trends of (very) high temperature gas-cooled reactors (HTGRs). In this paper, different cycle power generation schemes for HTGRs were systematically studied. Physical and mathematical models were established for these three cycle schemes: closed Brayton cycle, simple combined cycle, and reheated combined cycle. The effects and mechanism of key parameters such as reactor core outlet temperature, reactor core inlet temperature and compression ratio on the features of these cycles were analyzed. Then, optimization results were given with engineering restrictive conditions, including pinch point temperature differences. Results revealed that within the temperature range of HTGRs (700–900 °C), the reheated combined cycle had the highest efficiency, while the simple combined cycle had the lowest efficiency (900 °C). The efficiencies of the closed Brayton cycle, simple combined cycle and reheated combined cycle are 49.5%, 46.6% and 50.1%, respectively. These results provide insights on the different schemes of these cycles, and reveal the effects of key parameters on performance of these cycles. It could be helpful to understand and develop a combined cycle coupled with a high temperature reactor in the future.

  19. Towards Life Cycle Sustainability Assessment

    Directory of Open Access Journals (Sweden)

    Marzia Traverso

    2010-10-01

    Full Text Available Sustainability is nowadays accepted by all stakeholders as a guiding principle for both public policy making and corporate strategies. However, the biggest challenge for most organizations remains in the real and substantial implementation of the sustainability concept. The core of the implementation challenge is the question, how sustainability performance can be measured, especially for products and processes. This paper explores the current status of Life Cycle Sustainability Assessment (LCSA for products and processes. For the environmental dimension well established tools like Life Cycle Assessment are available. For the economic and social dimension, there is still need for consistent and robust indicators and methods. In addition to measuring the individual sustainability dimensions, another challenge is a comprehensive, yet understandable presentation of the results. The “Life Cycle Sustainability Dashboard” and the “Life Cycle Sustainability Triangle” are presented as examples for communication tools for both experts and non expert stakeholders.

  20. Endogenous, Imperfectly Competitive Business Cycles

    DEFF Research Database (Denmark)

    Whitta-Jacobsen, Hans Jørgen

    We investigate how imperfect competition affects the occurrence and the properties of endogenous, rational expectations business cycles in an overlapping generations model with constant returns to scale in production. The model has explicit product and labor markets all characterized...... by monopolistic competition. An implicit assumption of barriers to entry justifies that the number of firms is fixed even when positive profits occur. It turns out that both market power of firms on the product markets and market power of unions on the labor markets make the occurrence of cycles more likely....... In particular, imperfect competition on the product markets and the positive profits associated with it may have the effect that there is a cycle even if the labor supply curve is increasing in the real-wage rate. For competitive cycles is required not only a decreasing labor supply curve, but a wage elasticity...

  1. Air Quality Management Process Cycle

    Science.gov (United States)

    Air quality management are activities a regulatory authority undertakes to protect human health and the environment from the harmful effects of air pollution. The process of managing air quality can be illustrated as a cycle of inter-related elements.

  2. Ammonium generation during SRAT cycle

    International Nuclear Information System (INIS)

    Hsu, C.W.

    1992-01-01

    During the IDMS noble-metal demonstration runs ammonium nitrate deposition was found in the vessel vent system of the feed preparation area. In the bench-scale experiments of studying the hydrogen generation during the sludge treatment cycle, ammonium ion production was also monitored. It was found that: During a simulation of the DWPF Cold Chemical Runs SRAT cycle no detectable amount of ammonium ions was generated when treating a non-noble-metal containing sludge simulant according to the nitric acid flowsheet. Ammonium ions were generated during the SRAT-SME cycle when treating the noble-metal containing sludge with either formic acid or nitric acid/late-washing PHA. This is due to the reaction between formic acid and nitrate catalyzed by the noble metals in the sludge simulant. Ammonium ion production closely followed the hydrogen evolution from the catalytic decomposition of formic acid. This report summarizes the results of the production of ammonia during the SRAT cycle

  3. EPA Nonregulatory Nonroad Duty Cycles

    Science.gov (United States)

    EPA nonregulatory, nonroad duty cycles for equipment such as agricultural tractors, backhoe loaders,crawlers tractors, excavators, arc welding skid steer loaders, and wheel loaders. Also,test procedures, laboratory methods, and emissions for this equipmen

  4. Total Product Life Cycle (TPLC)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Total Product Life Cycle (TPLC) database integrates premarket and postmarket data about medical devices. It includes information pulled from CDRH databases...

  5. A model for global cycling of tritium

    International Nuclear Information System (INIS)

    Killough, G.G.; Kocher, D.C.

    1988-01-01

    Dynamic compartment models are widely used to describe global cycling of radionuclides for purposes of dose estimation. In this paper the authors present a new global tritium model that reproduces environmental time-series data on concentrations in precipitation, ocean surface waters, and surface fresh waters in the northern hemisphere, concentrations of atmospheric tritium in the southern hemisphere, and the latitude dependence of tritium in both hemispheres. Names TRICYCLE (for TRItium CYCLE) the model is based on the global hydrologic cycle and includes hemispheric stratospheric compartments, disaggregation of the troposphere and ocean surface waters into eight latitude zones, consideration of the different concentrations of atmospheric tritium over land and over the ocean, and a diffusive model for transport in the ocean. TRICYCLE reproduces the environmental data if it is assumed that about 50% of the tritium from atmospheric weapons testing was injected directly into the northern stratosphere as HTO. The model's latitudinal disaggregation permits taking into account the distribution of population. For a uniformly distributed release of HTO into the worldwide troposphere, TRICYCLE predicts a collective dose commitment to the world population that exceeds the NCRP model's corresponding prediction by a factor of three

  6. A model for global cycling of tritium

    International Nuclear Information System (INIS)

    Killough, G.G.; Kocher, D.C.

    1988-01-01

    Dynamic compartment models are widely used to describe global cycling of radionuclides for purposes of dose estimation. In this paper, we present a new global tritium model that reproduces environmental time-series data on concentrations in precipitation, ocean surface waters, and surface fresh waters in the northern hemisphere, concentrations of atmospheric tritium in the soutehrn hemisphere, and the latitude dependence of tritium in both hemispheres. Named TRICYCLE for Tritium CYCLE, the model is based on the global hydrologic cycle and includes hemisphereic stratospheric compartments, disaggregation of the troposphere and ocean surface waters into eight latitudezones, consideration of the different concentrations of atmospheric tritium over land and over the ocean, and a diffusive model for transport in the ocean. TRICYCLE reproduces the environmental data if we assume that about 50% of the tritium from atmospheric weapons testing was injected directly into the northern stratosphere as HTO. The models latitudinal disaggregation permits taking into account the distribution of population. For a unfiormaly distributed release of HTO into the worldwide troposphere, TRICYCLE predicts a collective dose commitment to the world population that exceeds the corresponding prediction by the NCRP model by about a factor of 3. 11 refs., 5 figs., 1 tab

  7. Detonation Jet Engine. Part 1--Thermodynamic Cycle

    Science.gov (United States)

    Bulat, Pavel V.; Volkov, Konstantin N.

    2016-01-01

    We present the most relevant works on jet engine design that utilize thermodynamic cycle of detonative combustion. The efficiency advantages of thermodynamic detonative combustion cycle over Humphrey combustion cycle at constant volume and Brayton combustion cycle at constant pressure were demonstrated. An ideal Ficket-Jacobs detonation cycle, and…

  8. On acyclicity of games with cycles

    DEFF Research Database (Denmark)

    Andersson, Klas Olof Daniel; Hansen, Thomas Dueholm; Gurvich, Vladimir

    2010-01-01

    We study restricted improvement cycles (ri-cycles) in finite positional n-person games with perfect information modeled by directed graphs (di-graphs) that may contain directed cycles (di-cycles). We assume that all these di-cycles form one outcome c, for example, a draw. We obtain criteria...

  9. Implications of alternative fuel cycles

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    The United States is re-examining alternative fuel cycles and nuclear power strategies, and doubtful attempts are being made to justify the economics of the 'throw-away' fuel cycle. At an international forum on 'An acceptable nuclear energy future for the world' at Fort Lauderdale, Karl Cohen of General Electric and a leading authority on this topic put the implications into perspective. Extracts from his address are presented

  10. Business Cycle Theory and Econometrics.

    OpenAIRE

    Gregory, Allan W; Smith, Gregor W

    1995-01-01

    We outline in turn criticisms made by econometricians of the methods used in empirical business-cycle research and then criticisms made by business-cycle researchers of some methods used by econometricians. The aim is to clarify and in some cases correct these criticisms. Overall there is no conflict in using rigourous statistical procedures to study modern dynamic stochastic general equilibrium models. We also provide a concise bibliography of recent research on statistical methods for busin...

  11. Advertising and Business Cycle Fluctuations

    OpenAIRE

    Benedetto Molinari; Francesco Turino

    2009-01-01

    This paper provides new empirical evidence of quarterly U.S. aggregate advertising expenditures, showing that advertising has a well defined pattern over the Business Cycle. To understand this pattern we develop a general equilibrium model where targeted advertising increases the marginal utility of the advertised good. Advertising intensity is endogenously determined by profit maximizing firms. We embed this assumption into an otherwise standard model of business cycle with monopolistic comp...

  12. Rapsodie: A closed fuel cycle

    International Nuclear Information System (INIS)

    Levallet, E.H.; Costa, L.; Mougniot, J.C.; Robin, J.

    1977-01-01

    The Fortissimo Version of the core of the RAPSODIE fast reactor produces 40 MWTh. Since its start up in May 1970 in the CEN-CADARACHE its availability has stayed around 85%. Some of the mixed oxyde fuel pins UO 2 - 30% PuO 2 have already reached 150.000 MWd/t. The reprocessing is done in the pilot plant located in the La Hague Center and the plutonium obtained has already been re-used in the reactor. The Rapsodie-Fortissimo cycle is therefore now a closed cycle. This cycle is quite representative of fast reactor cycle characteristics and thus provides a remarkable research and development tool for the study of fabrication, in-reactor performances, transport, storage and reprocessing. These studies concern in particular the evolution of fission products and heavy isotopes content in fuel which controls both reprocessing schemes and intensity of emitted radiations. A program for the analysis of irradiated fuel has been developed either using samples collected all along the cycle, or following the actual reprocessing subassemblies. A set of basic data and calculation models has been established with two objectives: to give a better interpretation of the experimental program on one hand, and to extrapolate these results to the fuel cycle of fast reactors in general on the other hand. The first results have been quite encouraging up to now [fr

  13. Cycle bases to the rescue

    Science.gov (United States)

    Tóbiás, Roland; Furtenbacher, Tibor; Császár, Attila G.

    2017-12-01

    Cycle bases of graph theory are introduced for the analysis of transition data deposited in line-by-line rovibronic spectroscopic databases. The principal advantage of using cycle bases is that outlier transitions -almost always present in spectroscopic databases built from experimental data originating from many different sources- can be detected and identified straightforwardly and automatically. The data available for six water isotopologues, H216O, H217O, H218O, HD16O, HD17O, and HD18O, in the HITRAN2012 and GEISA2015 databases are used to demonstrate the utility of cycle-basis-based outlier-detection approaches. The spectroscopic databases appear to be sufficiently complete so that the great majority of the entries of the minimum cycle basis have the minimum possible length of four. More than 2000 transition conflicts have been identified for the isotopologue H216O in the HITRAN2012 database, the seven common conflict types are discussed. It is recommended to employ cycle bases, and especially a minimum cycle basis, for the analysis of transitions deposited in high-resolution spectroscopic databases.

  14. Optimization of the fuel cycle

    International Nuclear Information System (INIS)

    Kidd, S.W.; Balu, K.; Boczar, P.G.; Krebs, W.D.

    1999-01-01

    The nuclear fuel cycle can be optimized subject to a wide range of criteria. Prime amongst these are economics, sustainability of resources, environmental aspects, and proliferation-resistance of the fuel cycle. Other specific national objectives will also be important. These criteria, and their relative importance, will vary from country to country, and with time. There is no single fuel cycle strategy that is optimal for all countries. Within the short term, the industry is attached to dominant thermal reactor technologies, which themselves have two main variants, a cycle closed by reprocessing of spent fuel and subsequent recycling and a once through one where spent fuel is stored in advance of geological disposal. However, even with current technologies, much can be done to optimize the fuel cycles to meet the relevant criteria. In the long term, resource sustainability can be assured for centuries through the use of fast breeder reactors, supporting high-conversion thermal reactors, possibly also utilizing the thorium cycle. These must, however, meet the other key criteria by being both economic and safe. (author)

  15. The NEWS Water Cycle Climatology

    Science.gov (United States)

    Rodell, M.; Beaudoing, H. K.; L'Ecuyer, T.; Olson, W. S.

    2012-12-01

    NASA's Energy and Water Cycle Study (NEWS) program fosters collaborative research towards improved quantification and prediction of water and energy cycle consequences of climate change. In order to measure change, it is first necessary to describe current conditions. The goal of the first phase of the NEWS Water and Energy Cycle Climatology project was to develop "state of the global water cycle" and "state of the global energy cycle" assessments based on data from modern ground and space based observing systems and data integrating models. The project was a multi-institutional collaboration with more than 20 active contributors. This presentation will describe the results of the water cycle component of the first phase of the project, which include seasonal (monthly) climatologies of water fluxes over land, ocean, and atmosphere at continental and ocean basin scales. The requirement of closure of the water budget (i.e., mass conservation) at various scales was exploited to constrain the flux estimates via an optimization approach that will also be described. Further, error assessments were included with the input datasets, and we examine these in relation to inferred uncertainty in the optimized flux estimates in order to gauge our current ability to close the water budget within an expected uncertainty range.

  16. The NEWS Water Cycle Climatology

    Science.gov (United States)

    Rodell, Matthew; Beaudoing, Hiroko Kato; L'Ecuyer, Tristan; William, Olson

    2012-01-01

    NASA's Energy and Water Cycle Study (NEWS) program fosters collaborative research towards improved quantification and prediction of water and energy cycle consequences of climate change. In order to measure change, it is first necessary to describe current conditions. The goal of the first phase of the NEWS Water and Energy Cycle Climatology project was to develop "state of the global water cycle" and "state of the global energy cycle" assessments based on data from modern ground and space based observing systems and data integrating models. The project was a multi-institutional collaboration with more than 20 active contributors. This presentation will describe the results of the water cycle component of the first phase of the project, which include seasonal (monthly) climatologies of water fluxes over land, ocean, and atmosphere at continental and ocean basin scales. The requirement of closure of the water budget (i.e., mass conservation) at various scales was exploited to constrain the flux estimates via an optimization approach that will also be described. Further, error assessments were included with the input datasets, and we examine these in relation to inferred uncertainty in the optimized flux estimates in order to gauge our current ability to close the water budget within an expected uncertainty range.

  17. Some alternatives to the mixed oxide fuel cycle

    International Nuclear Information System (INIS)

    Deonigi, D.E.; Eschbach, E.A.; Goldsmith, S.; Pankaskie, P.J.; Rohrmann, C.A.; Widrig, R.D.

    1977-02-01

    While on initial examination each of the six fuel cycle concepts (tandem cycle, extended burnup, fuel rejuvenation, coprocessing, partial reprocessing, and thorium) described in the report may have some potential for improving safeguards, none of the six appears to have any other major or compelling advantages over the mixed oxide (MOX) fuel cycle. Compared to the MOX cycle, all but coprocessing appear to have major disadvantages, including severe cost penalties. Three of the concepts-tandem, extended burnup, and rejuvenation--share the basic problems of the throwaway cycle (GESMO Alternative 6): without reprocessing, high-level waste volumes and costs are substantially increased, and overall uranium utilization decreases for three reasons. First, the parasitic fission products left in the fuel absorb neutrons in later irradiation steps reducing the overall neutronic efficiencies of these cycles. Second, discarded fuel still has sufficient fissile values to warrant recycle. Third, perhaps most important, the plutonium needed for breeder start-up will not be available; without the breeder, uranium utilization would drop by about a factor of sixty. Two of the concepts--coprocessing and partial reprocessing--involve variations of the basic MOX fuel cycle's chemical reprocessing step to make plutonium diversion potentially more difficult. These concepts could be used with the MOX fuel cycle or in conjunction with the tandem, extended burnup and rejuvenation concepts to eliminate some of the problems with those cycles. But in so doing, the basic impetus for those cycles--elimination of reprocessing for safeguards purposes--no longer exists. Of all the concepts considered, only coprocessing--and particularly the ''master blend'' version--appears to have sufficient promise to warrant a more detailed study. The master blend concept could possibly make plutonium diversion more difficult with minimal impact on the reprocessing and MOX fuel fabrication operations

  18. Dengue virus life cycle : viral and host factors modulating infectivity

    NARCIS (Netherlands)

    Rodenhuis-Zybert, Izabela A.; Wilschut, Jan; Smit, Jolanda M.

    Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen. All four DENV serotypes are prevalent in the (sub) tropical regions of the world and infect 50-100 million individuals annually. Whereas the majority of DENV infections proceed asymptomatically or result in self-limited

  19. TITAN'S TRANSPORT-DRIVEN METHANE CYCLE

    International Nuclear Information System (INIS)

    Mitchell, Jonathan L.

    2012-01-01

    The mechanisms behind the occurrence of large cloud outbursts and precipitation on Titan have been disputed. A global- and annual-mean estimate of surface fluxes indicated only 1% of the insolation, or ∼0.04 W m –2 , is exchanged as sensible and/or latent fluxes. Since these fluxes are responsible for driving atmospheric convection, it has been argued that moist convection should be quite rare and precipitation even rarer, even if evaporation globally dominates the surface-atmosphere energy exchange. In contrast, climate simulations indicate substantial cloud formation and/or precipitation. We argue that the top-of-atmosphere (TOA) radiative imbalance is diagnostic of horizontal heat transport by Titan's atmosphere, and thus constrains the strength of the methane cycle. Simple calculations show the TOA radiative imbalance is ∼0.5-1 W m –2 in Titan's equatorial region, which implies 2-3 MW of latitudinal heat transport by the atmosphere. Our simulation of Titan's climate suggests this transport may occur primarily as latent heat, with net evaporation at the equator and net accumulation at higher latitudes. Thus, the methane cycle could be 10-20 times previous estimates. Opposing seasonal transport at solstices, compensation by sensible heat transport, and focusing of precipitation by large-scale dynamics could further enhance the local, instantaneous strength of Titan's methane cycle by a factor of several. A limited supply of surface liquids in regions of large surface radiative imbalance may throttle the methane cycle, and if so, we predict more frequent large storms over the lakes district during Titan's northern summer.

  20. Fuel cycle for a fusion neutron source

    Energy Technology Data Exchange (ETDEWEB)

    Ananyev, S. S., E-mail: Ananyev-SS@nrcki.ru; Spitsyn, A. V., E-mail: spitsyn-av@nrcki.ru; Kuteev, B. V., E-mail: Kuteev-BV@nrcki.ru [National Research Center Kurchatov Institute (Russian Federation)

    2015-12-15

    The concept of a tokamak-based stationary fusion neutron source (FNS) for scientific research (neutron diffraction, etc.), tests of structural materials for future fusion reactors, nuclear waste transmutation, fission reactor fuel production, and control of subcritical nuclear systems (fusion–fission hybrid reactor) is being developed in Russia. The fuel cycle system is one of the most important systems of FNS that provides circulation and reprocessing of the deuterium–tritium fuel mixture in all fusion reactor systems: the vacuum chamber, neutral injection system, cryogenic pumps, tritium purification system, separation system, storage system, and tritium-breeding blanket. The existing technologies need to be significantly upgraded since the engineering solutions adopted in the ITER project can be only partially used in the FNS (considering the capacity factor higher than 0.3, tritium flow up to 200 m{sup 3}Pa/s, and temperature of reactor elements up to 650°C). The deuterium–tritium fuel cycle of the stationary FNS is considered. The TC-FNS computer code developed for estimating the tritium distribution in the systems of FNS is described. The code calculates tritium flows and inventory in tokamak systems (vacuum chamber, cryogenic pumps, neutral injection system, fuel mixture purification system, isotope separation system, tritium storage system) and takes into account tritium loss in the fuel cycle due to thermonuclear burnup and β decay. For the two facility versions considered, FNS-ST and DEMO-FNS, the amount of fuel mixture needed for uninterrupted operation of all fuel cycle systems is 0.9 and 1.4 kg, consequently, and the tritium consumption is 0.3 and 1.8 kg per year, including 35 and 55 g/yr, respectively, due to tritium decay.