WorldWideScience

Sample records for emplacing hl vitrified

  1. Development and demonstration of prototype transportation equipment for emplacing HL vitrified waste canisters into small diameter bored horizontal disposal cells

    International Nuclear Information System (INIS)

    Seidler, Wolf K.; Bosgiraud, Jean-Michel; Londe, Louis

    2008-01-01

    Over a period of 4 and years the National Radioactive Waste Management Agency (Andra), working with a variety of Contractors mostly specializing in nuclear orientated mechanical applications, successfully designed, fabricated and demonstrated 2 very different prototype high level waste transport systems. The first system, based on air cushion technology, was developed primarily for very heavy loads (17 to 45 tonnes). The results of this work are described in a separate presentation (Paper 21) at this Conference. The second system, developed by Andra within the framework of the ESDRED Project, generally referred to as the 'Pushing Robot System' for vitrified waste canisters, is the subject of this paper. The 'Pushing Robot System' is a part of the French national disposal concept that is described in Andra's 'Dossier 2005'. The latter is a public document that can be viewed on Andra's web site (www.andra.fr). The 'Pushing Robot System' system is designed for the deep geological disposal (in clay formations) of 'C' type vitrified waste canisters. In its entirety the system provides for the transport, emplacement and, if necessary, the retrieval of those canisters. Nothing in the design of the Andra emplacement equipment would preclude its utilization in horizontal openings in other types of geological settings. Over a period of some 8 years Andra has developed the 'Pushing Robot System' in 3 phases. Initially there was only the 'Conceptual Design' (Phase 1) which was incorporated in the Dossier 2005. This was followed by Phase 2 i.e. the design and fabrication of a simplified full scale prototype system henceforth referred to a P1, which includes a Pushing Robot, a Dummy Canister and a Test Bench. P1 details were also incorporated in the Dossier 2005. Finally, during Phase 3, a second more comprehensive full scale prototype system P2 has been designed and is being assembled and tested this month. This system includes a Transport Shuttle, a Transfer Shielding Cask, a

  2. Lessons learned in demonstration projects regarding operational safety during final disposal of vitrified waste and spent fuel

    International Nuclear Information System (INIS)

    Filbert, Wolfgang; Herold, Philipp

    2015-01-01

    The paper summarizes the lessons learned in demonstration projects regarding operational safety during the final disposal of vitrified waste and spent fuel. The three demonstration projects for the direct disposal of vitrified waste and spent fuel are described. The first two demonstration projects concern the shaft transport of heavy payloads of up to 85 t and the emplacement operations in the mine. The third demonstration project concerns the borehole emplacement operation. Finally, open issues for the next steps up to licensing of the emplacement and disposal systems are summarized.

  3. Emplacement engineering

    Energy Technology Data Exchange (ETDEWEB)

    Hill, Ernest E [Lawrence Radiation Laboratory, University of California, Livermore, CA (United States)

    1970-05-01

    Emplacement Engineering can be defined as that portion of a nuclear explosive project that is concerned with the emplacement of the explosive. This definition would then include virtually everything except the design and fabrication of the explosive and the post-shot-effects program. For future commercial application, the post-shot-effects program will essentially disappear. This emplacement portion of a nuclear explosive project constitutes a large fraction of the total project cost, but it has largely been overshadowed by the explosive and explosive-effects portions. As we move into commercial applications. Emplacement Engineering must receive more attention from both industry and government. To place emplacement costs in their proper relationship with total projects costs, we have performed a study of commercial underground nuclear explosive applications such as gas stimulation. Although there are many intangibles in such a study, we have been able to at least obtain some feel for the relative fractional costs of the non-explosive costs compared with the explosive costs. This study involved estimating the cost elements for applications using a single explosive at 5,000 ft, 10,000 ft, and 15,000 ft. For each depth, the cost estimates were made for a range of emplacement hole and explosive diameters. Results of these estimates for explosive-related costs, hole-related costs, and total costs are shown for the three depths. Note that the explosive package outside diameter is assumed as 2 inches less than the hole (or casing) inside diameter for all cases. For the 5,000-ft application the explosive-related costs dominate, and of particular importance is the indicated diameter for minimum total cost which occurs at approximately a 17.5-in. hole (15.5-in. explosive). The hole-related costs are in 'the same range as the explosive-related costs for the 10,000-ft application. For this case, the minimum total cost occurs at approximately a 14-in. hole (12-in. explosive

  4. Development of vitrified waste storage system

    International Nuclear Information System (INIS)

    Namiki, S.; Tani, Y.

    1993-01-01

    The authors have developed the radioactive waste vitrification technology and the vitrified waste storage technology. Regarding the vitrified waste storage system development, the authors have completed the design of two types of storage systems. One is a forced convection air cooling system, and the other is a natural convection air cooling system. They have carried out experiments and heat transfer analysis, seismic analysis, vitrified waste dropping and radiation shielding, etc. In this paper, the following three subjects, are discussed: the cooling air flow experiment, the wind effect experiment on the cooling air flow pattern, using a wind tunnel apparatus and the structural integrity evaluation on the dropping vitrified waste

  5. Vitrified waste option study report

    International Nuclear Information System (INIS)

    Lopez, D.A.; Kimmitt, R.R.

    1998-02-01

    A open-quotes Settlement Agreementclose quotes between the Department of Energy and the State of Idaho mandates that all radioactive high-level waste (HLW) now stored at the Idaho Chemical Processing Plant (ICPP) will be treated so that it is ready to be moved out of Idaho for disposal by a target date of 2035. This report investigates vitrification treatment of all ICPP calcine, including the existing and future HLW calcine resulting from calcining liquid Sodium-Bearing Waste (SBW). Currently, the SBW is stored in the tank farm at the ICPP. Vitrification of these wastes is an acceptable treatment method for complying with the Settlement Agreement. This method involves vitrifying the calcined waste and casting the vitrified mass into stainless steel canisters that will be ready to be moved out of the Idaho for disposal by 2035. These canisters will be stored at the Idaho National Engineering and Environmental Laboratory (INEEL) until they are sent to a HLW national repository. The operating period for vitrification treatment will be from 2013 through 2032; all HLW will be treated and in storage by the end of 2032

  6. Vitrified waste option study report

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, D.A.; Kimmitt, R.R.

    1998-02-01

    A {open_quotes}Settlement Agreement{close_quotes} between the Department of Energy and the State of Idaho mandates that all radioactive high-level waste (HLW) now stored at the Idaho Chemical Processing Plant (ICPP) will be treated so that it is ready to be moved out of Idaho for disposal by a target date of 2035. This report investigates vitrification treatment of all ICPP calcine, including the existing and future HLW calcine resulting from calcining liquid Sodium-Bearing Waste (SBW). Currently, the SBW is stored in the tank farm at the ICPP. Vitrification of these wastes is an acceptable treatment method for complying with the Settlement Agreement. This method involves vitrifying the calcined waste and casting the vitrified mass into stainless steel canisters that will be ready to be moved out of the Idaho for disposal by 2035. These canisters will be stored at the Idaho National Engineering and Environmental Laboratory (INEEL) until they are sent to a HLW national repository. The operating period for vitrification treatment will be from 2013 through 2032; all HLW will be treated and in storage by the end of 2032.

  7. Compatibility testing of vitrified waste forms

    International Nuclear Information System (INIS)

    Rankin, W.N.

    1978-01-01

    The compatibility of vitrified radioactive waste with candidate canister materials will be evaluated with both cast and in-can melted vitrified waste. Both real and simulated sludges will be used. In addition, the compatibility of these materials with salt from a possible final storage location will be determined. Cast vitrified waste will be tested with ASTM A 333 and ASTM A 516 low-carbon steels and Type 304L stainless steel at 100, 600 and 800 0 C. Cast vitrified waste that has been devitrified by heat treatment will be tested at 100 0 C. Two types of test specimens will be used with either simulated or real sludges: (1) unsealed capsules made of pieces of mill-finished pipe into which vitrified waste is cast, and (2) sealed capsules containing a small container of vitrified waste identical to the ones in the unsealed capsule. In-can melted vitrified waste will be tested with synthetic sludge only and with ASTM A 333 and ASTM A 516 low-carbon steels, Type 304L stainless steel and Inconel 600. Two types of tests will be carried out: (1) melting vitrified waste in miniature metal canisters and (2) exposure of small (carefully measured) metal coupons to molten glass. The air oxidation rates of candidate canister materials will be determined, and specimens will also be exposed to salt from Drill Hole AEC-8 in Carlsbad, New Mexico. Sealed capsules containing an ASTM A 516 low-carbon steel or Type 304L stainless steel specimen partially embedded in a small block of salt will be heated

  8. SUBSURFACE EMPLACEMENT TRANSPORTATION SYSTEM

    International Nuclear Information System (INIS)

    Wilson, T.; Novotny, R.

    1999-01-01

    The objective of this analysis is to identify issues and criteria that apply to the design of the Subsurface Emplacement Transportation System (SET). The SET consists of the track used by the waste package handling equipment, the conductors and related equipment used to supply electrical power to that equipment, and the instrumentation and controls used to monitor and operate those track and power supply systems. Major considerations of this analysis include: (1) Operational life of the SET; (2) Geometric constraints on the track layout; (3) Operating loads on the track; (4) Environmentally induced loads on the track; (5) Power supply (electrification) requirements; and (6) Instrumentation and control requirements. This analysis will provide the basis for development of the system description document (SDD) for the SET. This analysis also defines the interfaces that need to be considered in the design of the SET. These interfaces include, but are not limited to, the following: (1) Waste handling building; (2) Monitored Geologic Repository (MGR) surface site layout; (3) Waste Emplacement System (WES); (4) Waste Retrieval System (WRS); (5) Ground Control System (GCS); (6) Ex-Container System (XCS); (7) Subsurface Electrical Distribution System (SED); (8) MGR Operations Monitoring and Control System (OMC); (9) Subsurface Facility System (SFS); (10) Subsurface Fire Protection System (SFR); (11) Performance Confirmation Emplacement Drift Monitoring System (PCM); and (12) Backfill Emplacement System (BES)

  9. Solar energy emplacement developer

    Science.gov (United States)

    Mortensen, Michael; Sauls, Bob

    1991-01-01

    A preliminary design was developed for a Lunar Power System (LPS) composed of photovoltaic arrays and microwave reflectors fabricated from lunar materials. The LPS will collect solar energy on the surface of the Moon, transform it into microwave energy, and beam it back to Earth where it will be converted into usable energy. The Solar Energy Emplacement Developer (SEED) proposed will use a similar sort of solar energy collection and dispersement to power the systems that will construct the LPS.

  10. DOE regulatory reform initiative vitrified mixed waste

    International Nuclear Information System (INIS)

    Carroll, S.J.; Holtzscheiter, E.W.

    1997-01-01

    The US Department of Energy (DOE) is charged with responsibly managing the largest volume of mixed waste in the United States. This responsibility includes managing waste in compliance with all applicable Federal and State laws and regulations, and in a cost-effective, environmentally responsible manner. Managing certain treated mixed wastes in Resource Conservation and Recovery Act (RCRA) permitted storage and disposal units (specifically those mixed wastes that pose low risks from the hazardous component) is unlikely to provide additional protection to human health and the environment beyond that afforded by managing these wastes in storage and disposal units subject to requirements for radiological control. In October, 1995, the DOE submitted a regulatory reform proposal to the Environmental Protection Agency (EPA) relating to vitrified mixed waste forms. The technical proposal supports a regulatory strategy that would allow vitrified mixed waste forms treated through a permit or other environmental compliance mechanism to be granted an exemption from RCRA hazardous waste regulation, after treatment, based upon the inherent destruction and immobilization capabilities of vitrification technology. The vitrified waste form will meet, or exceed the performance criteria of the Environmental Assessment (EA) glass that has been accepted as an international standard for immobilizing radioactive waste components and the LDR treatment standards for inorganics and metals for controlling hazardous constituents. The proposal further provides that vitrified mixed waste would be responsibly managed under the Atomic Energy Act (AEA) while reducing overall costs. Full regulatory authority by the EPA or a State would be maintained until an acceptable vitrified mixed waste form, protective of human health and the environment, is produced

  11. The leaching characteristics of vitrified slag

    International Nuclear Information System (INIS)

    Zhang, Jinlong; Li, Yaojian; Tian, Junguo; Sheng, Hongzhi; Xu, Yongxiang

    2010-01-01

    Full Text: Plasma-arc technology was developed to fix the heavy metal of flying ash by the Institute of Mechanics, Chinese Academy of Sciences (CAS-IMECH). A direct current (DC) experimental facility of 30 kW with plasma-arc technology was setup to form vitrified slag. The additives (CaO, SiO 2 ) were added into the reactor to form vitrified slag and fix the heavy metal (Cr, Pb), under dissimilar condition (long and short heating-up time, natural and water cooling). Vitrified slag was broken into different particle size, from 0.1 mm to 1 cm. The particles with different specific surface area were used to study the leaching of heavy metals in vitrified slag rate of speed. The pH value of leaching solution are from 2 to 12, the experiment was kept at different external temperature, from 4 degree Celsius to 70 degree celsius, for 1 week to 1 month. Heavy metal leaching concentration was used to measure the chemical stability of vitrified slag. The results show that the higher specific surface area, the higher heavy metal leaching concentration, but when the specific surface area reaches a certain value, little change in leaching concentration. The impact of temperature on leaching concentration was not significant, from 4 degree Celsius to 70 degree Celsius. The leaching concentration increases with decreasing of the pH value of leaching solution when the pH value of leaching solution less than 7, and little change in concentration increases with pH value when the pH value of leaching solution more than 7. Compared with the leaching concentration after 1 month, the leaching concentration after 1 week has not changed significantly. (Author)

  12. HL-LHC Accelerator

    CERN Document Server

    Zimmermann, F

    2013-01-01

    The tentative schedule, key ingredients, as well as progress of pertinent R&D and component prototypes for the LHC luminosity upgrade, "HL-LHC," are reviewed. Also alternative scenarios based on performance-improving consolidations (PICs) instead of a full upgrade are discussed. Tentative time schedules and expected luminosity evolutions for the different scenarios are sketched. The important role of HL-LHC development as a step towards a future HE-LHC or VHE-LHC is finally highlighted. Presented at "Higgs & Beyond" Conference Tohoku University, Sendai 7 June 2013.

  13. Return of vitrified wastes from France to Japan; Retour des residus vitrifies de France au Japon

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The radioactive wastes resulting from the burnup of nuclear fuels in nuclear reactors represent 3 to 5% of the spent fuel. These wastes cannot be reused nor recycled and thus are vitrified after reprocessing. Japanese power companies have signed contracts with Cogema in France and BNFL in the UK for the reprocessing of their spent fuels. Then, the ultimate reprocessed wastes are sent back to Japan for storage. This information dossier takes stock of different questions relative to the transport of the vitrified wastes from France to Japan: why France sends back containers of vitrified wastes to Japan? What is a vitrified wastes container made of? How containers are transported? What is the regulatory frame applicable to these transports? Which safety measures are taken during transport? Which physical protection is applied? Which temporary storage facilities are used before and after transportation? How is performed the ultimate storage of wastes in Japan? Which quality and safety warranties are taken? Which emergency plans and exercises are provided? What are the applicable civil liability regimes? And what kind of information is given to the public about these transports. Some general information about energy and nuclear power worldwide, energy and environment, radioactivity, BNFL, Cogema and ORC is given in appendixes. (J.S.)

  14. Source term measurements on vitrified HLW

    International Nuclear Information System (INIS)

    Hough, A.; Marples, J.A.C.

    1988-01-01

    The equilibrium concentrations of Tc-99, Np-237, Pu-239/240 and Am-241 have been measured in the presence of materials likely to be present in a vitrified HLW repository: glass, iron, backfill and rock. Results were measured under both oxidising and reducing conditions and at pH values set by the backfill bentonite and cement. Under reducing conditions and with cementitious backfills, the equilibrium concentrations ranged from three to 30 times allowed drinking water levels for the four isotopes. (author)

  15. TRANSPORT AND EMPLACEMENT EQUIPMENT DESCRIPTIONS

    International Nuclear Information System (INIS)

    1997-01-01

    The objective and the scope of this document are to list and briefly describe the major mobile equipment necessary for waste package (WP) Transport and Emplacement in the proposed subsurface nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the equipment are explained and summarized in the individual subsections of this document. The Transport and Emplacement equipment described in this document consists of the following: (1) WP Transporter; (2) Reusable Rail Car; (3) Emplacement Gantry; (4) Gantry Carrier; and (5) Transport Locomotive

  16. NDA issues with RFETS vitrified waste forms

    International Nuclear Information System (INIS)

    Hurd, J.; Veazey, G.

    1998-01-01

    A study was conducted at Los Alamos National Laboratory (LANL) for the purpose of determining the feasibility of using a segmented gamma scanner (SGS) to accurately perform non-destructive analysis (NDA) on certain Rocky Flats Environmental Technology Site (RFETS) vitrified waste samples. This study was performed on a full-scale vitrified ash sample prepared at LANL according to a procedure similar to that anticipated to be used at RFETS. This sample was composed of a borosilicate-based glass frit, blended with ash to produce a Pu content of ∼1 wt %. The glass frit was taken to a degree of melting necessary to achieve a full encapsulation of the ash material. The NDA study performed on this sample showed that SGSs with either 1/2- or 2-inch collimation can achieve an accuracy better than 6 % relative to calorimetry and γ-ray isotopics. This accuracy is achievable, after application of appropriate bias corrections, for transmissions of about 1/2 % through the waste form and counting times of less than 30 minutes. These results are valid for ash material and graphite fines with the same degree of plutonium particle size, homogeneity, sample density, and sample geometry as the waste form used to obtain the results in this study. A drum-sized thermal neutron counter (TNC) was also included in the study to provide an alternative in the event the SGS failed to meet the required level of accuracy. The preliminary indications are that this method will also achieve the required accuracy with counting times of ∼30 minutes and appropriate application of bias corrections. The bias corrections can be avoided in all cases if the instruments are calibrated on standards matching the items

  17. HL-LHC alternatives

    CERN Document Server

    Tomás, R; White, S

    2014-01-01

    The HL-LHC parameters assume unexplored regimes for hadron colliders in various aspects of accelerator beam dynamics and technology. This paper reviews three alternatives that could potentially improve the LHC performance: (i) the alternative filling scheme 8b+4e, (ii) the use of a 200 MHz RF system in the LHC and (iii) the use of proton cooling methods to reduce the beam emittance (at top energy and at injection). The alternatives are assessed in terms of feasibility, pros and cons, risks versus benefits and the impact on beam availability.

  18. Construction, emplacement, and retrievability (preclosure)

    International Nuclear Information System (INIS)

    McClain, W.

    1985-01-01

    Each of the three preclosure subgroups of the Construction, Emplacement, and Retrievability Working Group adopted a six-step approach to identify and assess current needs in geotechnical modeling and characterization. This approach may be summarized as follows: identify phenomena related to emplacement of high-level nuclear wastes, identify types of models which are required to calculate the phenomena, establish the input data needs for the models, assess the current availability of the models, assess the current status of documentation, verification, and validation of the models, and determine the adequacy of instrumentation and measurement techniques to (a) validate the models, where necessary, and (b) obtain input data for design. Systematic application of these six steps leads to the establishment of the research requirements for geotechnical modeling and characterization. A summary of modeling techniques which apply to the three subsequent sections on construction, emplacement, and retrievability is presented. Research needs, which apply to all preclosure activities, are summarized

  19. Elements of transport and emplacement system

    International Nuclear Information System (INIS)

    1981-02-01

    This report, undertaken to review proposals for transport, handling and emplacement of high-level radioactive wastes in an underground repository, appropriate to the U.K. context, falls under the headings: basic design concepts; waste block size and configuration; self-shielded or partially shielded blocks; concept of emplacement in long boreholes; concept of emplacement in short boreholes; concept of emplacement in tunnels; methods of emplacement; stages of disposal; repository access by adit, incline or shaft; handling techniques within repository; conventional and radiological safety; costs; areas for further research and development. (U.K.)

  20. Vitrified chemically bonded phosphate ceramics for immobilization of radioisotopes

    Science.gov (United States)

    Wagh, Arun S.

    2016-04-05

    A method of immobilizing a radioisotope and vitrified chemically bonded phosphate ceramic (CBPC) articles formed by the method are described. The method comprises combining a radioisotope-containing material, MgO, a source of phosphate, and optionally, a reducing agent, in water at a temperature of less than 100.degree. C. to form a slurry; curing the slurry to form a solid intermediate CBPC article comprising the radioisotope therefrom; comminuting the intermediate CBPC article, mixing the comminuted material with glass frits, and heating the mixture at a temperature in the range of about 900 to about 1500.degree. C. to form a vitrified CBPC article comprising the radioisotope immobilized therein.

  1. Emplacement Gantry Gap Analysis Study

    International Nuclear Information System (INIS)

    Thornley, R.

    2005-01-01

    To date, the project has established important to safety (ITS) performance requirements for structures, systems, and components (SSCs) based on the identification and categorization of event sequences that may result in a radiological release. These performance requirements are defined within the ''Nuclear Safety Design Bases for License Application'' (NSDB) (BSC 2005 [DIRS 171512], Table A-11). Further, SSCs credited with performing safety functions are classified as ITS. In turn, assurance that these SSCs will perform as required is sought through the use of consensus codes and standards. This gap analysis is based on the design completed for license application only. Accordingly, identification of ITS SSCs beyond those defined within the NSDB are based on designs that may be subject to further development during detail design. Furthermore, several design alternatives may still be under consideration to satisfy certain safety functions, and final selection will not be determined until further design development has occurred. Therefore, for completeness, alternative designs currently under consideration will be discussed throughout this study. This gap analysis will evaluate each code and standard identified within the ''Emplacement Gantry ITS Standards Identification Study'' (BSC 2005 [DIRS 173586]) to ensure each ITS performance requirement is fully satisfied. When a performance requirement is not fully satisfied, a gap is highlighted. This study will identify requirements to supplement or augment the code or standard to meet performance requirements. Further, this gap analysis will identify nonstandard areas of the design that will be subject to a design development plan. Nonstandard components and nonstandard design configurations are defined as areas of the design that do not follow standard industry practices or codes and standards. Whereby, assurance that an SSC will perform as required may not be readily sought though the use of consensus standards. This

  2. Providing flexibility in spent fuel and vitrified waste management

    International Nuclear Information System (INIS)

    Bradley, N.; O'Tallamhain, C.; Brown, G.A.

    1986-01-01

    The UK Central Electricity Generating Board is pondering a decision to build a dry vault store as a buffer in its overall AGR spent fuel management programme. The application of the dry vault is not limited to fuel from gas cooled reactors, it can be used for spent LWR fuel and vitrified waste. A cutaway diagram of such a vault is presented. (UK)

  3. Return of vitrified wastes from France to Japan

    International Nuclear Information System (INIS)

    2000-01-01

    The radioactive wastes resulting from the burnup of nuclear fuels in nuclear reactors represent 3 to 5% of the spent fuel. These wastes cannot be reused nor recycled and thus are vitrified after reprocessing. Japanese power companies have signed contracts with Cogema in France and BNFL in the UK for the reprocessing of their spent fuels. Then, the ultimate reprocessed wastes are sent back to Japan for storage. This information dossier takes stock of different questions relative to the transport of the vitrified wastes from France to Japan: why France sends back containers of vitrified wastes to Japan? What is a vitrified wastes container made of? How containers are transported? What is the regulatory frame applicable to these transports? Which safety measures are taken during transport? Which physical protection is applied? Which temporary storage facilities are used before and after transportation? How is performed the ultimate storage of wastes in Japan? Which quality and safety warranties are taken? Which emergency plans and exercises are provided? What are the applicable civil liability regimes? And what kind of information is given to the public about these transports. Some general information about energy and nuclear power worldwide, energy and environment, radioactivity, BNFL, Cogema and ORC is given in appendixes. (J.S.)

  4. Low temperature irradiation of vitrifiable mixtures of unsaturated monomers

    International Nuclear Information System (INIS)

    Kaetsu, I.; Ito, A.; Hayashi, K.

    1975-01-01

    A specific mixture containing at least one polymerizable unsaturated monomer which is not vitrifiable by itself can advantageously be polymerized by irradiating the mixture at a temperature not higher than 100 0 C above glass transition temperature of the mixture with an ionizing radiation and/or a light. 12 claims, 6 drawings, figures

  5. European experience in transport/storage cask for vitrified residues

    International Nuclear Information System (INIS)

    Otton, Camille; Sicard, Damien

    2007-01-01

    Available in abstract form only. Full text of publication follows: Because of the evolution of burnup of spent fuel to be reprocessed, the high activity vitrified residues would not be transported in the existing cask designs. Therefore, TN International has decided in the late nineties to develop a brand new design of casks with optimized capacity able to store and transport the most active and hottest canisters: the TN TM 81 casks currently in use in Switzerland and the TN TM 85 cask which shall permit in the near future in Germany the storage and the transport of the most active vitrified residues defining a thermal power of 56 kW (kilowatts). The challenges for the TN TM 81 and TN TM 85 cask designs were that the geometry entry data were very restrictive and were combined with a fairly wide range set by the AREVA NC Specification relative to vitrified residue canister. The TN TM 81 and the TN TM 85 casks have been designed to fully anticipate shipment constraints of the present vitrified residue production. It also used the feedback of current shipments and the operational constraints and experience of receiving and shipping facilities. The casks had to fit as much as possible in the existing procedures for the already existing flasks such as the TN TM 28 cask and TS 28 V cask, all along the logistics chain of loading, unloading, transport and maintenance. (authors)

  6. Magma emplacement in 3D

    Science.gov (United States)

    Gorczyk, W.; Vogt, K.

    2017-12-01

    Magma intrusion is a major material transfer process in Earth's continental crust. Yet, the mechanical behavior of the intruding magma and its host are a matter of debate. In this study, we present a series of numerical thermo-mechanical experiments on mafic magma emplacement in 3D.In our model, we place the magmatic source region (40 km diameter) at the base of the mantle lithosphere and connect it to the crust by a 3 km wide channel, which may have evolved at early stages of magmatism during rapid ascent of hot magmatic fluids/melts. Our results demonstrate continental crustal response due to magma intrusion. We observe change in intrusion geometries between dikes, cone-sheets, sills, plutons, ponds, funnels, finger-shaped and stock-like intrusions as well as injection time. The rheology and temperature of the host-rock are the main controlling factors in the transition between these different modes of intrusion. Viscous deformation in the warm and deep crust favours host rock displacement and magma pools along the crust-mantle boundary forming deep-seated plutons or magma ponds in the lower to middle-crust. Brittle deformation in the cool and shallow crust induces cone-shaped fractures in the host rock and enables emplacement of finger- or stock-like intrusions at shallow or intermediate depth. A combination of viscous and brittle deformation forms funnel-shaped intrusions in the middle-crust. Low-density source magma results in T-shaped intrusions in cross-section with magma sheets at the surface.

  7. Keeping HL-LHC accountable

    CERN Multimedia

    2015-01-01

    This week saw the cost and schedule of the High Luminosity LHC (HL-LHC) and LHC Injectors Upgrade (LIU) projects come under close scrutiny from the external review committee set up for the purpose.    HL-LHC, whose implementation requires an upgrade to the CERN injector complex, responds directly to one of the key recommendations of the updated European Strategy for Particle Physics, which urges CERN to prepare for a ‘major luminosity upgrade’, a recommendation that is also perfectly in line with the P5 report on the US strategy for the field. Responding to this recommendation, CERN set up the HL-LHC project in 2013, partially supported by FP7 funding through the HiLumi LHC Design Study (2011-2015), and coordinated with the American LARP project, which oversees the US contribution to the upgrade. A key element of HL-LHC planning is a mechanism for receiving independent expert advice on all aspects of the project.  To this end, several technical reviews h...

  8. Ground Control for Emplacement Drifts for LA

    International Nuclear Information System (INIS)

    Y. Sun

    2004-01-01

    The purpose of this calculation is to analyze the stability of repository emplacement drifts during the preclosure period, and to provide a final ground support method for emplacement drifts for the License Application (LA). The scope of the work includes determination of input parameter values and loads, selection of appropriate process and methods for the calculation, application of selected methods, such as empirical or analytical, to the calculation, development and execution of numerical models, and evaluation of results. Results from this calculation are limited to use for design of the emplacement drifts and the final ground support system installed in these drifts. The design of non-emplacement openings and their ground support systems is covered in the ''Ground Control for Non-Emplacement Drifts for LA'' (BSC 2004c)

  9. Emplacement technology for the direct disposal of spent fuel into deep vertical boreholes

    International Nuclear Information System (INIS)

    Bollingerfehr, W.; Filbert, W.; Wehrmann, J.

    2008-01-01

    In the early sixties it was decided to investigate salt formations on its suitability to host heat generating radioactive waste in Germany. In the reference repository concept consequently the emplacement of vitrified waste canisters in deep vertical boreholes inside a salt mine was considered whereas spent fuel should be disposed of in self shielding casks (type POLLUX) in horizontal drifts. The POLLUX casks, 65 t heavy carbon steel casks, will be laid down on the floor of a horizontal drift in one of the disposal zones to be constructed in the salt dome at the 870 m level. The space between casks and drift walls will be backfilled with crushed salt. The transport, the handling und the emplacement of POLLUX casks were subject of successfully performed demonstration and in situ tests in the nineties and resulted in an adjustment of the atomic law. The borehole disposal concept comprises the emplacement of unshielded canisters with vitrified HLW in boreholes with a diameter of 60 cm and a depth of up to 300 m. In order to facilitate the fast encapsulation of the waste canister by the host rock (rock salt), no lining of the boreholes is planned. With regard to harmonize and optimize the emplacement technology for both categories of packages (vitrified waste and spent fuel) alternatives were developed. In this context the borehole emplacement technique for consolidated spent fuel as already foreseen for high-level reprocessing waste was reconsidered. This review resulted in the design of a new disposal package, a fuel rod canister (type 'BSK 3'), and an appropriate modified transport and emplacement technology. This concept (called BSK 3-concept) provides the following optimization possibilities: (i) A new steel canister of the same diameter (43 cm) as the standardized HLW canisters applied for high-level waste and compacted technological waste from reprocessing abroad can be filled with fuel rods of 3 PWR or 9 BWR fuel assemblies. (II) The standardized canister

  10. Emplacement of Columbia River flood basalt

    Science.gov (United States)

    Reidel, Stephen P.

    1998-11-01

    Evidence is examined for the emplacement of the Umatilla, Wilbur Creek, and the Asotin Members of Columbia River Basalt Group. These flows erupted in the eastern part of the Columbia Plateau during the waning phases of volcanism. The Umatilla Member consists of two flows in the Lewiston basin area and southwestern Columbia Plateau. These flows mixed to form one flow in the central Columbia Plateau. The composition of the younger flow is preserved in the center and the composition of the older flow is at the top and bottom. There is a complete gradation between the two. Flows of the Wilbur Creek and Asotin Members erupted individually in the eastern Columbia Plateau and also mixed together in the central Columbia Plateau. Comparison of the emplacement patterns to intraflow structures and textures of the flows suggests that very little time elapsed between eruptions. In addition, the amount of crust that formed on the earlier flows prior to mixing also suggests rapid emplacement. Calculations of volumetric flow rates through constrictions in channels suggest emplacement times of weeks to months under fast laminar flow for all three members. A new model for the emplacement of Columbia River Basalt Group flows is proposed that suggests rapid eruption and emplacement for the main part of the flow and slower emplacement along the margins as the of the flow margin expands.

  11. Statistical estimate for evaluation of vitrified radioactive wastes

    International Nuclear Information System (INIS)

    Jedinakova-Krizova, V.; Dvorak, Z.

    1994-01-01

    The evaluation of experimental results by methods of mathematical statistics gave a chance to derive a number of conclusions on the leachability of vitrified radioactive wastes. Practical application of this procedure requires that the ratio of Na and K concentration in the solution should be independent of the leaching time- The actual value of this ratio is influenced. above all. by the properties of the glass matrix. These results confirm the ion that Na/K correlation found could be extended for the determination of the Na/ 137 Cs concentration ratio. This finding was used for the application of a ln-ln correlation, while evaluation the quality of vitrified radioactive wastes products. (author) 7 refs.; 5 figs.; 1 tab

  12. Properties of vitrified rocky flats TRUW with different waste loadings

    International Nuclear Information System (INIS)

    Eddy, T.L.; Sears, J.W.; Grandy, J.D.; Miley, D.V.; Erickson, A.W.; Farnsworth, R.N.; Larsen, E.D.

    1994-01-01

    Leach rates, phase structures, and mechanical properties of simulated Rocky Flats Plant 1st and 2nd slate sludge vitrified in an arc melter are described as a function of waste to soil fraction and method of devitrification to produce the glass-ceramic waste form. Volatile, hazardous, and transuranic (TRU) surrogate metals were added to assess dissolution effects. Zirconia and titania were also added to confirm their ability as transuranic-surrogate getters

  13. Wire-rope emplacement of diagnostics systems

    International Nuclear Information System (INIS)

    Burden, W.L.

    1982-01-01

    The study reported here was initiated to determine if, with the Cable Downhole System (CDS) currently under development, there is an advantage to using continuous wire rope to lower the emplacement package to the bottom of the hole. A baseline design using two wire ropes as well as several alternatives are discussed in this report. It was concluded that the advantages of the wire-rope emplacement system do not justify the cost of converting to such a system, especially for LLNL's maximum emplacement package weights

  14. Waste package emplacement borehole option study

    International Nuclear Information System (INIS)

    Streeter, W.S.

    1992-03-01

    This study evaluates the cost and thermal effects of various waste package emplacement configurations that differ in emplacement orientation, number of containers per borehole, and standoff distance at the potential Yucca Mountain nuclear waste repository. In this study, eight additional alternatives to the vertical and horizontal orientation options presented in the Site Characterization Plan Conceptual Design Report are considered. Typical panel layout configurations based on thermal analysis of the waste and cost estimates for design and construction, operations, and closure and decommissioning were made for each emplacement option. For the thermal analysis average waste 10 years out of reactor and the SIM code were used to determine whether the various configurations temperatures would exceed the design criteria for temperature. This study does not make a recommendation for emplacement configuration, but does provide information for comparison of alternatives

  15. Effects of Fault Displacement on Emplacement Drifts

    International Nuclear Information System (INIS)

    Duan, F.

    2000-01-01

    The purpose of this analysis is to evaluate potential effects of fault displacement on emplacement drifts, including drip shields and waste packages emplaced in emplacement drifts. The output from this analysis not only provides data for the evaluation of long-term drift stability but also supports the Engineered Barrier System (EBS) process model report (PMR) and Disruptive Events Report currently under development. The primary scope of this analysis includes (1) examining fault displacement effects in terms of induced stresses and displacements in the rock mass surrounding an emplacement drift and (2 ) predicting fault displacement effects on the drip shield and waste package. The magnitude of the fault displacement analyzed in this analysis bounds the mean fault displacement corresponding to an annual frequency of exceedance of 10 -5 adopted for the preclosure period of the repository and also supports the postclosure performance assessment. This analysis is performed following the development plan prepared for analyzing effects of fault displacement on emplacement drifts (CRWMS M and O 2000). The analysis will begin with the identification and preparation of requirements, criteria, and inputs. A literature survey on accommodating fault displacements encountered in underground structures such as buried oil and gas pipelines will be conducted. For a given fault displacement, the least favorable scenario in term of the spatial relation of a fault to an emplacement drift is chosen, and the analysis is then performed analytically. Based on the analysis results, conclusions are made regarding the effects and consequences of fault displacement on emplacement drifts. Specifically, the analysis will discuss loads which can be induced by fault displacement on emplacement drifts, drip shield and/or waste packages during the time period of postclosure

  16. Retention of 137Cs and 90Sr by mineral sorbents surrounding vitrified nuclear waste

    International Nuclear Information System (INIS)

    Lyon, K.E.; Patterson, R.J.

    1985-01-01

    In June 1960, twenty-five 14-cm diameter hemispheres of vitrified nuclear waste (glass blocks) were buried in a shallow sand aquifer in the lower Perch Lake Basin, Chalk River Nuclear Laboratories, Ontario, Canada. Almost all leaching of the glass blocks occurred during the first 18 months of emplacement, and consequently the burial experiment approximated a single-injection source of 137 Cs and 90 Sr. After about 11 years, most of the 90 Sr that was released had been advected and dispersed from the site, whereas the bulk of the 137 Cs had travelled no more than 0.3 m from the blocks. Three piezometers were installed and five cores of sediment were collected at the glass block site in 1978. Mineralogically pure segregates of sand grains were prepared by hand and characterized using binocular, petrographic and scanning electron microscopy, X-ray diffraction, and energy-dispersive X-ray spectroscopy. A technique also was developed to measure very low levels of 137 Cs and 90 Sr by counting small (10-100 mg) sediment samples directly with a thin window, flow proportional counter. Results show that sand-sized grains of altered biotite (biotite-vermiculite), biotite, muscovite, hornblende and serictized feldspar are able to retain 137 Cs over a period of 18 years, and that grains of biotite-vermiculite, biotite and hematite-bearing feldspar (largely microline) can retain low levels of 90 Sr over the same period of time. The amounts of 137 Cs and 90 Sr sorbed by the mineral grains ranged from undetectable levels to approximately 380 and 35 becquerels/gram sediment, respectively. This report contains the complete series of mineral segregates ranked on a weight basis according to the amounts of retained 137 Cs and 90 Sr. Ground-water quality data indicate that none of the retention is the result of the precipitation of strontium or cesium minerals

  17. HL-A27 and anterior uveitis.

    Science.gov (United States)

    Woodrow, J C; Mapstone, R; Anderson, J; Usher, N

    1975-09-01

    HL-A types were determined in 90 successive patients with non-granulomatous uveitis. Fifty-one were HL-A27 positive (55.7%) compared to 8.2% of controls. Of 16 patients with ankylosing spondylitis, 13 were HL-A27 positive, as were two patients with a history of Reiter's syndrome. Twenty-eight patients were HL-A27 positive but had no evidence of rheumatic disease. The findings are discussed in relation to the possible pathogenesis of uveitis.

  18. Evaluation of shipping doses and compositions for vitrified waste

    International Nuclear Information System (INIS)

    Shapiro, A.

    1996-01-01

    Shipments of radioactive materials must adhere to dose limits specified in the Code of Federal Regulations. This paper discusses methods for evaluating shipping doses of vitrified waste. A methodology was developed for evaluating the change in vitrification composition required to maintain shipping dose rates within limits. The point kernel codes QAD and Microshield were used to evaluate dose equivalent rates from specified waste forms and radioactivity measurements. The Origen code was utilized to provide the gamma-ray activity as a function of time from isotopic activity measurements. This gamma-ray activity served as source input for QAD. Microshield developed its own source from the given isotopic activities

  19. Characterisation of Plasma Vitrified Simulant Plutonium Contaminated Material Waste

    International Nuclear Information System (INIS)

    Hyatt, Neil C.; Morgan, Suzy; Stennett, Martin C.; Scales, Charlie R.; Deegan, David

    2007-01-01

    The potential of plasma vitrification for the treatment of a simulant Plutonium Contaminated Material (PCM) was investigated. It was demonstrated that the PuO 2 simulant, CeO 2 , could be vitrified in the amorphous calcium iron aluminosilicate component of the product slag with simultaneous destruction of the organic and polymer waste fractions. Product Consistency Tests conducted at 90 deg. C in de-ionised water and buffered pH 11 solution show the PCM slag product to be durable with respect to release of Ce. (authors)

  20. Implementation of the full-scale emplacement (FE) experiment at the Mont Terri rock laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Müller, H.R.; Garitte, B.; Vogt, T.; and others

    2017-04-15

    Opalinus Clay is currently being assessed as the host rock for a deep geological repository for high-level and low- and intermediate-level radioactive wastes in Switzerland. Within this framework, the 'Full-Scale Emplacement' (FE) experiment was initiated at the Mont Terri rock laboratory close to the small town of St-Ursanne in Switzerland. The FE experiment simulates, as realistically as possible, the construction, waste emplacement, backfilling and early post-closure evolution of a spent fuel/vitrified high-level waste disposal tunnel according to the Swiss repository concept. The main aim of this multiple heater test is the investigation of repository-induced thermo-hydro-mechanical (THM) coupled effects on the host rock at this scale and the validation of existing coupled THM models. For this, several hundred sensors were installed in the rock, the tunnel lining, the bentonite buffer, the heaters and the plug. This paper is structured according to the implementation timeline of the FE experiment. It documents relevant details about the instrumentation, the tunnel construction, the production of the bentonite blocks and the highly compacted 'granulated bentonite mixture' (GBM), the development and construction of the prototype 'backfilling machine' (BFM) and its testing for horizontal GBM emplacement. Finally, the plug construction and the start of all 3 heaters (with a thermal output of 1350 Watt each) in February 2015 are briefly described. In this paper, measurement results representative of the different experimental steps are also presented. Tunnel construction aspects are discussed on the basis of tunnel wall displacements, permeability testing and relative humidity measurements around the tunnel. GBM densities achieved with the BFM in the different off-site mock-up tests and, finally, in the FE tunnel are presented. Finally, in situ thermal conductivity and temperature measurements recorded during the first heating months

  1. Local geology controlled the feasibility of vitrifying Iron Age buildings.

    Science.gov (United States)

    Wadsworth, Fabian B; Heap, Michael J; Damby, David E; Hess, Kai-Uwe; Najorka, Jens; Vasseur, Jérémie; Fahrner, Dominik; Dingwell, Donald B

    2017-01-12

    During European prehistory, hilltop enclosures made from polydisperse particle-and-block stone walling were exposed to temperatures sufficient to partially melt the constituent stonework, leading to the preservation of glassy walls called 'vitrified forts'. During vitrification, the granular wall rocks partially melt, sinter viscously and densify, reducing inter-particle porosity. This process is strongly dependent on the solidus temperature, the particle sizes, the temperature-dependence of the viscosity of the evolving liquid phase, as well as the distribution and longevity of heat. Examination of the sintering behaviour of 45 European examples reveals that it is the raw building material that governs the vitrification efficiency. As Iron Age forts were commonly constructed from local stone, we conclude that local geology directly influenced the degree to which buildings were vitrified in the Iron Age. Additionally, we find that vitrification is accompanied by a bulk material strengthening of the aggregates of small sizes, and a partial weakening of larger blocks. We discuss these findings in the context of the debate surrounding the motive of the wall-builders. We conclude that if wall stability by bulk strengthening was the desired effect, then vitrification represents an Iron Age technology that failed to be effective in regions of refractory local geology.

  2. PLUTONIUM/HIGH-LEVEL VITRIFIED WASTE BDBE DOSE CALCULATION

    Energy Technology Data Exchange (ETDEWEB)

    J.A. Ziegler

    2000-11-20

    The purpose of this calculation is to provide a dose consequence analysis of high-level waste (HLW) consisting of plutonium immobilized in vitrified HLW to be handled at the proposed Monitored Geologic Repository at Yucca Mountain for a beyond design basis event (BDBE) under expected conditions using best estimate values for each calculation parameter. In addition to the dose calculation, a plutonium respirable particle size for dose calculation use is derived. The current concept for this waste form is plutonium disks enclosed in cans immobilized in canisters of vitrified HLW (i.e., glass). The plutonium inventory at risk used for this calculation is selected from Plutonium Immobilization Project Input for Yucca Mountain Total Systems Performance Assessment (Shaw 1999). The BDBE examined in this calculation is a nonmechanistic initiating event and the sequence of events that follow to cause a radiological release. This analysis will provide the radiological releases and dose consequences for a postulated BDBE. Results may be considered in other analyses to determine or modify the safety classification and quality assurance level of repository structures, systems, and components. This calculation uses best available technical information because the BDBE frequency is very low (i.e., less than 1.0E-6 events/year) and is not required for License Application for the Monitored Geologic Repository. The results of this calculation will not be used as part of a licensing or design basis.

  3. Ground Control for Emplacement Drifts for SR

    International Nuclear Information System (INIS)

    Y. Sun

    2000-01-01

    This analysis demonstrates that a satisfactory ground control system can be designed for the Yucca Mountain site, and provides the technical basis for the design of ground support systems to be used in repository emplacement and non-emplacement drifts. The repository ground support design was based on analytical methods using acquired computer codes, and focused on the final support systems. A literature review of case histories, including the lessons learned from the design and construction of the ESF, the studies on the seismic damages of underground openings, and the use of rock mass classification systems in the ground support design, was conducted (Sections 6.3.4 and 6.4). This review provided some basis for determining the inputs and methodologies used in this analysis. Stability of the supported and unsupported emplacement and non-emplacement drifts was evaluated in this analysis. The excavation effects (i.e., state of the stress change due to excavation), thermal effects (i.e., due to heat output from waste packages), and seismic effects (i.e., from potential earthquake events) were evaluated, and stress controlled modes of failure were examined for two in situ stress conditions (k 0 =0.3 and 1.0) using rock properties representing rock mass categories of 1 and 5. Variation of rock mass units such as the non-lithophysal (Tptpmn) and lithophysal (Tptpll) was considered in the analysis. The focus was on the non-lithophysal unit because this unit appears to be relatively weaker and has much smaller joint spacing. Therefore, the drift stability and ground support needs were considered to be controlled by the design for this rock unit. The ground support systems for both emplacement and non-emplacement drifts were incorporated into the models to assess their performance under in situ, thermal, and seismic loading conditions. Both continuum and discontinuum modeling approaches were employed in the analyses of the rock mass behavior and in the evaluation of the

  4. Automated emplacement and retrieval of hazardous waste

    International Nuclear Information System (INIS)

    Slocum, A.H.; Hou, W.M.

    1987-01-01

    The design of several dedicated machines to perform simple tasks often results in higher system reliability and efficiency than the design of a single, multifunctional machine. Similarly, a reliable system for emplacement and retrieval of nuclear waste can be realized if emplacement/retrieval operations are decomposed into a well-defined series of independent tasks. The basic methodology is to design a system that eliminates contact between the waste package and the vehicle in the event of machine failure. The disabled vehicle can then be withdrawn to a safe location, repaired, and set back to resume normal operation

  5. HL-LHC parameter space and scenarios

    International Nuclear Information System (INIS)

    Bruning, O.S.

    2012-01-01

    The HL-LHC project aims at a total integrated luminosity of approximately 3000 fb -1 over the lifetime of the HL-LHC. Assuming an exploitation period of ca. 10 years this goal implies an annual integrated luminosity of approximately 200 fb -1 to 300 fb -1 per year. This paper looks at potential beam parameters that are compatible with the HL-LHC performance goals and discusses briefly potential variation in the parameter space. It is shown that the design goal of the HL-LHC project can only be achieved with a full upgrade of the injector complex and the operation with β* values close to 0.15 m. Significant margins for leveling can be achieved for β* values close to 0.15 m. However, these margins can only be harvested during the HL-LHC operation if the required leveling techniques have been demonstrated in operation

  6. Pilot Peter Hoag and HL-10

    Science.gov (United States)

    1969-01-01

    Air Force Major Peter Hoag stands in front of the HL-10 Lifting Body. Maj. Hoag joined the HL-10 program in 1969 and made his first glide flight on June 6, 1969. He made a total of 8 flights in the HL-10. They included the fastest lifting-body flight, which reached Mach 1.861 on Feb. 18, 1970. The HL-10 was one of five heavyweight lifting-body designs flown at NASA's Flight Research Center (FRC--later Dryden Flight Research Center), Edwards, California, from July 1966 to November 1975 to study and validate the concept of safely maneuvering and landing a low lift-over-drag vehicle designed for reentry from space. Northrop Corporation built the HL-10 and M2-F2, the first two of the fleet of 'heavy' lifting bodies flown by the NASA Flight Research Center. The contract for construction of the HL-10 and the M2-F2 was $1.8 million. 'HL' stands for horizontal landing, and '10' refers to the tenth design studied by engineers at NASA's Langley Research Center, Hampton, Va. After delivery to NASA in January 1966, the HL-10 made its first flight on Dec. 22, 1966, with research pilot Bruce Peterson in the cockpit. Although an XLR-11 rocket engine was installed in the vehicle, the first 11 drop flights from the B-52 launch aircraft were powerless glide flights to assess handling qualities, stability, and control. In the end, the HL-10 was judged to be the best handling of the three original heavy-weight lifting bodies (M2-F2/F3, HL-10, X-24A). The HL-10 was flown 37 times during the lifting body research program and logged the highest altitude and fastest speed in the Lifting Body program. On Feb. 18, 1970, Air Force test pilot Peter Hoag piloted the HL-10 to Mach 1.86 (1,228 mph). Nine days later, NASA pilot Bill Dana flew the vehicle to 90,030 feet, which became the highest altitude reached in the program. Some new and different lessons were learned through the successful flight testing of the HL-10. These lessons, when combined with information from it's sister ship, the M2

  7. Synthesis long life storage studies surface storage of vitrified wastes

    International Nuclear Information System (INIS)

    Beziat, A.; Breton, E.; Ranc, G.; Gaillard, J.P.; Lagrave, H.; Hollender, F.; Jourdain, F.; Piault, E.; Garnier, J.; Lamare, V.; Duret, B.; Helie, M.; Ferry, C.; Mijuin, D.; Gagnier, E.

    2004-01-01

    This document is realized in the framework of the axis 3 of the law of 1991 on the radioactive wastes management. It justifies the choices concerning long time surface storage installation of vitrified wastes, called high activity wastes. The long time of the installation would reach 300 years at the maximum. These wastes represent 1 % at the maximum, of radioactive wastes in France but 95 % of the whole radioactivity. Three main objectives were followed: provide a permanent containment of radionuclides; give the possibility of wastes containers retrieval at all the time; minimize the maintenance and the control. The results allow to conclude that the long time surface storage of high activity wastes is feasible. (A.L.B.)

  8. Operational and safety aspects of vitrified waste casks

    International Nuclear Information System (INIS)

    Kirchner, B.

    1993-01-01

    For the time being two technical solutions have been developed for the interim storage: 1) one is based on forced air cooled pits set out in a concrete structure, as presently provided close to the Vitrification Facilities on reprocessing sites; 2) the other one is based on transportable storage casks standing vertically onto a storage pad, following principles similar to those already experienced with spent fuel storage casks. Considering these two solutions for interim storage, TRANSNUCLEAIRE has developed two main types of transportable casks for vitrified HAW; one is a routine transport cask; the other one is a transportable storage cask. Both are covered by the generic name TN28V and have already been described in previous papers. This paper deals with the safety and operation aspects of the casks under both transport and storage conditions. (J.P.N.)

  9. Comparing technical concepts for disposal of Belgian vitrified HLW

    International Nuclear Information System (INIS)

    Bel, J.; Bock, C. de; Boyazis, J.P.

    2004-01-01

    The choice of a suitable repository design for different categories of radioactive waste is an important element in the decisional process that will eventually lead to the waste disposal in geological ground layers during the next decades. Most countries are in the process of elaborating different technical solutions for their EBS '. Considering possible design alternatives offers more flexibility to cope with remaining uncertainties and allows optimizing some elements of the EBS in the future. However, it is not feasible to continue carrying out detailed studies for a large number of alternative design options. At different stages in the decisional process, choices, even preliminary ones, have to be made. Although the impact of different stakeholders (regulator, waste agencies, waste producers, research centers,...) in making these design choices can differ from one country to another, the choices should be based on sound, objective, clear and unambiguous justification grounds. Moreover, the arguments should be carefully reported and easy to understand by the decision makers. ONDRAF/NIRAS recently elaborated three alternative designs for the disposal of vitrified HLW. These three designs are briefly described in the next section. A first series of technological studies pointed out that the three options are feasible. It would however be unreasonable to continue R and D work on all three alternatives in parallel. It is therefore planned to make a preliminary choice of a reference design for the vitrified HLW in 2003. This selection will depend on the way the alternative design options can be evaluated against a number of criteria, mainly derived from general repository design requirements. The technique of multi-criteria analysis (MCA) will be applied as a tool for making the optimum selection, considering all selection criteria and considering different strategic approaches. This paper describes the used methodology. The decision on the actual selection will be

  10. Study on behaviour in long term of vitrified materials

    International Nuclear Information System (INIS)

    Vernaz, E.

    1993-01-01

    In collaboration with EDF (Electricite de France), after testing fusion of Refiom (Residus d'Epuration des Fumees d'Incineration d'Ordures Menageres), residues from purification of incineration smokes of household rubbish, realised at Porcheville and at the Laboratory of Renardieres with experimental processing of vitrification by plasma, CEA (Centre d'Etudes Atomiques), atomic center of research, began study on resistance in long term of vitrified products. From about thirty five years, CEA carries out research to confine radioactive waste of high activity in stable materials. Glass was the first best one which allowed to incorporate about thirty different chemical elements found in fission products solutions into a stable die with a good chemical durability; three vitrification shops raised, one at Marcoule ('AVM', 1978) in the south of France, the two other ones at La Hague ('R7', 1989 and 'T7', 1992) in Normandy. To determine a possible impact of a deep radioactive waste disposal on human and environment, several studies began. In particular, studies on aqueous corrosion of glasses to determine behaviour in long term of glass package (first barrier of confinement) and to estimate kinetics of releasing confined toxical elements on periods of several thousands years. Principal results are exposed in this conference. Experience shows that safety analysis cannot be based on long term extrapolation of a simple lixiviation result. This analysis must include: a sufficient knowledge in basic mechanisms of alteration to predict the kinetic evolution in a long term. To take in account environment conditions with a normal or accidental scheme (acidity, clay, organic compounds,...). This knowledge broadly developed by CEA for nuclear glasses seems to be easily transposable to different wastes (industrial ones or from hospitals) and takes place in a contract of research CEA/EDF to valorize vitrified products. 9 figs. 4 refs

  11. Longevity of Emplacement Drift Ground Support Materials

    International Nuclear Information System (INIS)

    D.H.Tang

    2001-01-01

    The purpose of this analysis is to evaluate the factors affecting the longevity of emplacement drift ground support materials and to develop a basis for the selection of materials for ground support that will function throughout the preclosure period of a potential repository at Yucca Mountain. REV 01 ICN 01 of this analysis is developed in accordance with AP-3.10Q, Analyses and Models, Revision 2, ICN 4, and prepared in accordance with the Technical Work Plan for Subsurface Design Section FY 01 Work Activities (CRWMS M and O 2001a). The objective of this analysis is to update the previous analysis (CRWMS M and O 2000a) to account for related changes in the Ground Control System Description Document (CRWMS M and O 2000b), the Monitored Geologic Repository Project Description Document, which is included in the Requirements and Criteria for Implementing a Repository Design that can be Operated Over a Range of Thermal Modes (BSC 2001), input information, and in environmental conditions, and to provide updated information on candidate ground support materials. Candidate materials for ground support are carbon steel and cement grout. Steel is mainly used for steel sets, lagging, channel, rock bolts, and wire mesh. Cement grout is only considered in the case of grouted rock bolts. Candidate materials for the emplacement drift invert are carbon steel and granular natural material. Materials are evaluated for the repository emplacement drift environment based on the updated thermal loading condition and waste package design. The analysis consists of the following tasks: (1) Identify factors affecting the longevity of ground support materials for use in emplacement drifts. (2) Review existing documents concerning the behavior of candidate ground support materials during the preclosure period. (3) Evaluate impacts of temperature and radiation effects on mechanical and thermal properties of steel. Assess corrosion potential of steel at emplacement drift environment. (4

  12. Emplacement of small and large buffer blocks

    International Nuclear Information System (INIS)

    Saari, H.; Nikula, M.; Suikki, M.

    2010-05-01

    The report describes emplacement of a buffer structure encircling a spent fuel canister to be deposited in a vertical hole. The report deals with installability of various size blocks and with an emplacement gear, as well as evaluates the achieved quality of emplacement and the time needed for installing the buffer. Two block assembly of unequal size were chosen for examination. A first option involved small blocks, the use of which resulted in a buffer structure consisting of small sector blocks 200 mm in height. A second option involved large blocks, resulting in a buffer structure which consists of eight blocks. In these tests, the material chosen for both block options was concrete instead of bentonite. The emplacement test was a three-phase process. A first phase included stacking a two meter high buffer structure with small blocks for ensuring the operation of test equipment and blocks. A second phase included installing buffer structures with both block options to a height matching that of a canister-encircling cylindrical component. A third phase included testing also the installability of blocks to be placed above the canister by using small blocks. In emplacement tests, special attention was paid to the installability of blocks as well as to the time required for emplacement. Lifters for both blocks worked well. Due to the mass to be lifted, the lifter for large blocks had a more heavy-duty frame structure (and other lifting gear). The employed lifters were suspended in the tests on a single steel wire rope. Stacking was managed with both block sizes at adequate precision and stacked-up towers were steady. The stacking of large blocks was considerably faster. Therefore it is probably that the overall handling of the large blocks will be more convenient at a final disposal site. From the standpoint of reliability in lifting, the small blocks were safer to install above the canister. In large blocks, there are strict shape-related requirements which are

  13. The HL-LHC accelerator physics challenges

    CERN Document Server

    Fartoukh, S

    2014-01-01

    We review the conceptual baseline of the HL-LHC project, putting into perspective the main beam physics challenges of this new collider in comparison with the existing LHC, and the series of solutions and possible mitigation measures presently envisaged.

  14. The HL-LHC Accelerator Physics Challenges

    Science.gov (United States)

    Fartoukh, S.; Zimmermann, F.

    The conceptual baseline of the HL-LHC project is reviewed, putting into perspective the main beam physics challenges of this new collider in comparison with the existing LHC, and the series of solutions and possible mitigation measures presently envisaged.

  15. The HL-LHC accelerator physics challenges

    CERN Document Server

    Fartoukh, S

    2015-01-01

    The conceptual baseline of the HL-LHC project is reviewed, putting into perspective the main beam physics challenges of this new collider in comparison with the existing LHC, and the series of solutions and possible mitigation measures presently envisaged.

  16. Cryovolcanic Emplacement of Domes on Europa

    Science.gov (United States)

    Quick, Lynnae C.; Glaze, Lori S.; Baloga, Stephen M.

    2016-01-01

    Here we explore the hypothesis that certain domes on Europa may have been produced by the extrusion of viscous cryolavas. A new mathematical method for the emplacement and relaxation of viscous lava domes is presented and applied to putative cryovolcanic domes on Europa. A similarity solution approach is applied to the governing equation for fluid flow in a cylindrical geometry, and dome relaxation is explored assuming a volume of cryolava has been rapidly emplaced onto the surface. Nonphysical sin- gularities inherent in previous models for dome relaxation have been eliminated, and cryolava cooling is represented by a time-variable viscosity. We find that at the onset of relaxation, bulk kinematic viscosities may lie in the range between 10(exp 3) and 10(exp 6) sq m/s, while the actual fluid lava viscosity may be much lower. Plausible relaxation times to form the domes, which are linked to bulk cryolava rheology, are found to range from 3.6 days to 7.5 years. We find that cooling of the cryolava, while dominated by conduction through an icy skin, should not prevent fluids from advancing and relaxing to form domes within the timescales considered. Determining the range of emplacement conditions for putative cryolava domes will shed light on Europa's resurfacing history. In addition, the rheologies and compositions of erupted cryolavas have implications for subsurface cryomagma ascent and local surface stress conditions on Europa.

  17. Longevity of Emplacement Drift Ground Support Materials

    International Nuclear Information System (INIS)

    Tang, D.

    2000-01-01

    The purpose of this analysis is to evaluate the factors affecting the longevity of emplacement drift ground support materials and to develop a basis for selection of materials for ground support that will function throughout the preclosure period. The Development Plan (DP) for this analysis is given in CRWMS M and O (Civilian Radioactive Waste Management System Management and Operating Contractor) (1999a). The candidate materials for ground support are steel (carbon steel, ductile cast iron, galvanized steel, and stainless steel, etc.) and cement. Steel will mainly be used for steel sets, lagging, channels, rock bolts, and wire mesh. Cement usage is only considered in the case of grouted rock bolts. The candidate materials for the invert structure are steel and crushed rock ballast. The materials shall be evaluated for the repository emplacement drift environment under a specific thermal loading condition based on the proposed License Application Design Selection (LADS) design. The analysis consists of the following tasks: (1) Identify factors affecting the longevity of ground control materials for use in emplacement drifts. (2) Review existing documents concerning behavior of candidate ground control materials during the preclosure period. The major criteria to be considered for steel are mechanical and thermal properties, and durability, of which corrosion is the most important concern. (3) Evaluate the available results and develop recommendations for material(s) to be used

  18. TBV 361 RESOLUTION ANALYSIS: EMPLACEMENT DRIFT ORIENTATION

    International Nuclear Information System (INIS)

    Lin, M.; Kicker, D.C.; Sellers, M.D.

    1999-01-01

    The purpose of this To Be Verified/To Be Determined (TBX) resolution analysis is to release ''To Be Verified'' (TBV)-361 related to the emplacement drift orientation. The system design criterion in ''Subsurface Facility System Description Document'' (CRWMS M andO 1998a, p.9) specifies that the emplacement drift orientation relative to the dominant joint orientations should be at least 30 degrees. The specific objectives for this analysis include the following: (1) Collect and evaluate key block data developed for the repository host horizon rock mass. (2) Assess the dominant joint orientations based on available fracture data. (3) Document the maximum block size as a function of drift orientation. (4) Assess the applicability of the drift orientation/joint orientation offset criterion in the ''Subsurface Facility System Description Document'' (CRWMS M andO 1998a, p.9). (5) Consider the effects of seepage on drift orientation. (6) Verify that the viability assessment (VA) drift orientation complies with the drift orientation/joint orientation offset criterion, or provide justifications and make recommendations for modifying the VA emplacement drift layout. In addition to providing direct support to the System Description Document (SDD), the release of TBV-361 will provide support to the Repository Subsurface Design Department. The results from this activity may also provide data and information needs to support the MGR Requirements Department, the MGR Safety Assurance Department, and the Performance Assessment Organization

  19. The generation of live offspring from vitrified oocytes.

    Directory of Open Access Journals (Sweden)

    L Gabriel Sanchez-Partida

    Full Text Available Oocyte cryopreservation is extremely beneficial for assisted reproductive technologies, the treatment of infertility and biotechnology and offers a viable alternative to embryo freezing and ovarian grafting approaches for the generation of embryonic stem cells and live offspring. It also offers the potential to store oocytes to rescue endangered species by somatic cell nuclear transfer and for the generation of embryonic stem cells to study development in these species. We vitrified mouse oocytes using a range of concentrations of trehalose (0 to 0.3 M and demonstrated that 0.1 and 0.3 M trehalose had similar developmental rates, which were significantly different to the 0.2 M cohort (P<0.05. As mitochondria are important for fertilisation outcome, we observed that the clustering and distribution of mitochondria of the 0.2 M cohort were more affected by vitifrication than the other groups. Nevertheless, all 3 cohorts were able to develop to blastocyst, following in vitro fertilisation, although developmental rates were better for the 0.1 and 0.3 M cohorts than the 0.2 M cohort (P<0.05. Whilst blastocysts gave rise to embryonic stem-like cells, it was apparent from immunocytochemistry and RT-PCR that these cells did not demonstrate true pluripotency and exhibited abnormal karyotypes. However, they gave rise to teratomas following injection into SCID mice and differentiated into cells of each of the germinal layers following in vitro differentiation. The transfer of 2-cell embryos from the 0.1 and 0.3 M cohorts resulted in the birth of live offspring that had normal karyotypes (9/10. When 2-cell embryos from vitrified oocytes underwent vitrification, and were thawed and transferred, live offspring were obtained that exhibited normal karyotypes, with the exception of one offspring who was larger and died at 7 months. We conclude that these studies highlight the importance of the endometrial environment for the maintenance of genetic stability and

  20. Pre-disposal storage, transport and handling of vitrified high level waste

    International Nuclear Information System (INIS)

    Kempe, T.F.; Martin, A.

    1981-05-01

    The objectives of the study were to review non site-specific engineering features of the storage, transport and handling of vitrified high level radioactive waste prior to its transfer into an underground repository, and to identify those features which require validation or development. Section headings are: introduction (historical and technical background); characteristics and arisings of vitrified high level waste; overpacks (additional containment barrier, corrosion resistant); interim storage of HLW; transport of HLW; handling; conclusions and recommendations. (U.K.)

  1. Development of improved leaching techniques for vitrified radioactive waste products

    International Nuclear Information System (INIS)

    Vaswani, G.A.; Yeotikar, R.G.; Rastogi, R.C.; Sunder Rajan, N.S.

    1979-01-01

    A critical review of the current techniques for evaluating the leach resistance of vitrified radioactive wastes has been made. Inadequacy of the available leaching techniques, with respect to their adoption as standard technique on an international scale, has been brought out for the three broad catagories of aqueous attack viz., (i) simple contact with leachant at a particular temperature, (ii) once-through or recirculatory flow of leachant at variable temperatures and flow rates, and (iii) contact with freshly distilled hot water in soxhelet type of extractor. In an effort to evolve a standard leaching technique in the latter two categories of aqueous attack, development of two leaching units viz., 'Dynamic Leaching Unit' and 'Modified Soxhlet Unit' is described. Both these units offer good control and wide flexibility on the important parameters affecting leaching such as leachant temperature, flow rate of residence time of leachant and ratio of leachant volume to sample surface area. The dynamic leaching units also offers a good control and flexibility on the two additional parameters viz., the composition and pH of the leachant. In the modified soxhlet unit the composition and pH of the leachant remains near to that of distilled water. The leach rate results have been found to be reproducible. A need for framing the set of standard conditions for adoption of these units in evolution of standard leaching techniques has been indicated. (auth.)

  2. Performance implications of waste package emplacement orientation

    International Nuclear Information System (INIS)

    Wilder, D.G.

    1991-05-01

    Emplacement borehole orientation directly impacts many aspects of the Engineered Barrier System (EBS) and interactions with the near field environment. This paper considers the impacts of orientation on the hydrologic portion of the environment and its interactions with the EBS. The hydrologic environment is considered from a conceptual standpoint, the numerical analyses are left for subsequent work. As reported in this paper, several aspects of the hydrological environment are more favorable for long term performance of vertically oriented rather than horizontally oriented Waste Packages. 19 refs., 15 figs

  3. EMPLACEMENT GANTRY ITS STANDARDS IDENTIFICATION STUDY

    International Nuclear Information System (INIS)

    Voegele, M.

    2005-01-01

    To date, the project has established ITS performance requirements for SSCs based on identification and categorization of event sequences that may result in a radiological release. These performance requirements are defined within the NSDB. Further, SSCs credited with performing safe functions are classified as ITS. In turn, perform confirmation for these SSCs is sought through the use of consensus code and standards. The purpose of this study is to identify applicable codes and standards for the WP Emplacement Gantry ITS SSCs. Further, this study will form the basis for selection and the extent of applicability of each code and standard. This study is based on the design development completed for LA only. Accordingly, identification of ITS SSCs beyond those defined within the NSDB are based on designs that may be subject to further development during detail design. Furthermore, several design alternatives may still be under consideration to satisfy certain safety functions, and that final selection will not be determined until further design development has occurred. Therefore, for completeness, throughout this study alternative designs currently under considered will be discussed. Further, the results of this study will be subject to evaluation as part of a follow-on GAP analysis study. Based on the results of this study the GAP analysis will evaluate each code and standard to ensure each ITS performance requirement is fully satisfied. When a performance requirement is not fully satisfied a ''gap'' is highlighted. Thereafter, the study will identify supplemental requirements to augment the code or standard to meet performance requirements. Further, the GAP analysis will identify non-standard areas of the design that will be subject to a Development Plan. Non-standard components and non-standard design configurations are defined as areas of the design that do not follow standard industry practices or codes and standards. Whereby, performance confirmation cannot be

  4. The full-scale Emplacement (FE) Experiment at the Mont Terri URL

    International Nuclear Information System (INIS)

    Mueller, H.R.; Weber, H.P.; Koehler, S.; Vogt, T.; Vietor, T.

    2012-01-01

    Document available in extended abstract form only. The Full-Scale Emplacement (FE) Experiment at the Mont Terri underground research laboratory (URL) is a full-scale heater test in a clay-rich formation. It simulates the construction, waste emplacement and backfilling of a spent fuel (SF) / vitrified high-level waste (HLW) repository tunnel as realistically as possible. The entire experiment implementation as well as the post-closure THM(C) evolution will be monitored using several hundred sensors. These are distributed in the host rock in the near- and far-field, the tunnel lining, the engineered barrier system and on the heaters. The aim of this experiment is to investigate HLW repository-induced thermo-hydro-mechanical (THM) coupled effects on the host rock and the validation of existing coupled THM models. A further aim is the verification of the technical feasibility of constructing a 50 m repository section at full scale with all relevant components using standard industrial equipment. Finally, the experiment will demonstrate the canister and buffer emplacement procedures for underground conditions based on the Swiss disposal concept. Experimental layout The FE experiment is based on the Swiss disposal concept for SF / HLW. The 50 m long test gallery, at the end of the former MB test tunnel in the Mont Terri URL, will be realised with a diameter of approx. 3 m. In the experiment gallery, 3 heaters with dimensions similar to those of waste canisters will be emplaced on top of abutments built of bentonite blocks. The remaining space will be backfilled with compacted bentonite pellets. The experiment will be sealed off towards the start niche with a concrete plug holding the buffer in place and reducing air and water fluxes. The first scoping calculations and design modelling for the 'far-field' instrumentation have been completed; these works have been carried out using CodeBRIGHT and the multiphase flow simulator TOUGH2. With an initial heat output of 1500 W

  5. EMPLACEMENT DRIFT ISOLATION DOOR CONTROL SYSTEM

    International Nuclear Information System (INIS)

    N.T. Raczka

    1998-01-01

    The purpose of this analysis is to review and refine key design concepts related to the control system presently under consideration for remotely operating the emplacement drift isolation doors at the potential subsurface nuclear waste repository at Yucca Mountain. This analysis will discuss the key design concepts of the control system that may be utilized for remotely monitoring, opening, and closing the emplacement drift isolation doors. The scope and primary objectives of this analysis are to: (1) Discuss the purpose and function of the isolation doors (Presented in Section 7.1). (2) Review the construction of the isolation door and other physical characteristics of the doors that the control system will interface with (Presented in Section 7.2). (3) Discuss monitoring and controlling the operation of the isolation doors with a digital control system (either a Programmable Logic Controller (PLC) system or a Distributed Control System (DCS)) (Presented in Section 7.3). (4) Discuss how all isolation doors can be monitored and controlled from a subsurface central control center (Presented in Section 7.4). This analysis will focus on the development of input/output (I/O) counts including the types of I/O, redundancy and fault tolerance considerations, and processor requirements for the isolation door control system. Attention will be placed on operability, maintainability, and reliability issues for the system operating in the subsurface environment with exposure to high temperatures and radiation

  6. Estimation of the heat generation in vitrified waste product and shield thickness of the cask for the transportation of vitrified waste product using Monte Carlo technique

    International Nuclear Information System (INIS)

    Deepa, A.K.; Jakhete, A.P.; Mehta, D.; Kaushik, C.P.

    2011-01-01

    High Level Liquid waste (HLW) generated during reprocessing of spent fuel contains most of the radioactivity present in the spent fuel resulting in the need for isolation and surveillance for extended period of time. Major components in HLW are the corrosion products, fission products such as 137 Cs, 90 Sr, 106 Ru, 144 Ce, 125 Sb etc, actinides and various chemicals used during reprocessing of spent fuel. Fresh HLW having an activity concentration of around 100Ci/l is to be vitrified into borosilicate glass and packed in canisters which are placed in S.S overpacks for better confinement. These overpacks contain around 0.7 Million Curies of activity. Characterisation of activity in HLW and activity profile of radionuclides for various cooling periods sets the base for the study. For transporting the vitrified waste product (VWP), two most important parameters is the shield thickness of the transportation cask and the heat generation in the waste product. This paper describes the methodology used in the estimation of lead thickness for the transportation cask using the Monte Carlo Technique. Heat generation due to decay of fission products results in the increase in temperature of the vitrified waste product during interim storage and disposal. Glass being the material, not having very high thermal conductivity, temperature difference between the canister and surrounding bears significance in view of the possibility of temperature based devitrification of VWP. The heat generation in the canister and the overpack containing vitrified glass is also estimated using MCNP. (author)

  7. Deep Borehole Emplacement Mode Hazard Analysis Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Sevougian, S. David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-08-07

    This letter report outlines a methodology and provides resource information for the Deep Borehole Emplacement Mode Hazard Analysis (DBEMHA). The main purpose is identify the accident hazards and accident event sequences associated with the two emplacement mode options (wireline or drillstring), to outline a methodology for computing accident probabilities and frequencies, and to point to available databases on the nature and frequency of accidents typically associated with standard borehole drilling and nuclear handling operations. Risk mitigation and prevention measures, which have been incorporated into the two emplacement designs (see Cochran and Hardin 2015), are also discussed. A key intent of this report is to provide background information to brief subject matter experts involved in the Emplacement Mode Design Study. [Note: Revision 0 of this report is concentrated more on the wireline emplacement mode. It is expected that Revision 1 will contain further development of the preliminary fault and event trees for the drill string emplacement mode.

  8. Cross border transport of vitrified residues from France to Germany

    International Nuclear Information System (INIS)

    Graf, W.; Jussofie, A.

    2016-01-01

    Until 1994 reprocessing was the only legal way to manage German spent fuel. Since in 1984 the national reprocessing concept was abandoned the reprocessing abroad was the only existing disposal route. With the amendment of the Atomic Energy Act in 2002 spent fuel management changed completely since from 1 June 2005 any delivery of spent fuel to reprocessing plants was prohibited and the direct disposal of spent fuel became mandatory. Until 2005 the total amount of spent fuel to be reprocessed abroad added up to 6080 t HM, 5309 t HM thereof in France. According to the commercial contracts signed between the German utilities and COGEMA, now AREVA NC, in France and BNFL, now INS in UK, and to the intergovernmental agreements concluded between Germany and France or UK the waste generated from reprocessing has to be returned to Germany. The return of high active vitrified waste from La Hague to the interim storage facility at Gorleben was not only demanding from the view of safety ensured by the cask design but especially for security reasons since the Gorleben area served as a target for nuclear opponents from the first transport in 1996 to the latest one in 2010. The protection against sabotage of the railway lines and mass protests needed improved security measures. Special working forces and projects have been set up in France and Germany to cope with this situation. A complex transport organization was necessary to involve all parties in line with the German and French security requirements during transport. All transports have been completed successfully so far thus confirming the efficiency of the applied measures. (author)

  9. Concept of Operations for Waste Transport, Emplacement, and Retrieval

    International Nuclear Information System (INIS)

    Raczka, Norman T.

    2001-01-01

    The preparation of this technical report has two objectives. The first objective is to discuss the base case concepts of waste transport, emplacement, and retrieval operations and evaluate these operations relative to a lower-temperature repository design. Aspects of the operations involved in waste transport, emplacement and retrieval may be affected by the lower-temperature operating schemes. This report evaluates the effects the lower-temperature alternatives may have on the operational concepts involved in emplacing and retrieving waste. The second objective is to provide backup material for the design description, in a traceable and defensible format, for Section 2 of the Waste Emplacement/Retrieval System Description Document

  10. Performances of the HL (Hyperloop) transport system

    NARCIS (Netherlands)

    van Goeverden, C.D.; Milakis, D.; Janic, M.; Konings, J.W.; Cools, M.; Limbourg, S.

    2017-01-01

    This paper deals with an analysis of performances of the HL (Hyperloop) transport system considered as an advanced transport alternative to the existing APT (Air Passenger Transport) and HSR (High Speed Rail) systems. The considered performances are operational, financial, social and environmental.

  11. HL7 Messaging Engine with Customizable Translation System

    Directory of Open Access Journals (Sweden)

    PRODAN, R.

    2010-05-01

    Full Text Available This paper introduces a new client-server messaging engine used to exchange clinical data between various medical software applications. Our portal uses the HL7 (Health Level Seven messaging standard to provide translated clinical data to HL7 and non-HL7 client applications. We used HL7 because this standard is worldwide used to facilitate the communication between clinical applications.

  12. Improved parthenogenetic development of vitrified-warmed bovine oocytes activated with 9% ethanol plus 6-DMAP

    DEFF Research Database (Denmark)

    Hou, Y -p; Liu, Ying; Dai, Y -p

    2009-01-01

    The objective was to compare various activation protocols on developmental potential of vitrified bovine oocytes. Bovine oocytes matured in vitro for 23 h were vitrified with EDFSF30 in open pulled straws. After warming, they were cultured in vitro for 1 h, followed by parthenogenetic activation....... Vitrified-warmed oocytes had a morphologically normal rate similar to that of controls (nonvitrified oocytes cultured in vitro for 24 h; 98.6% vs. 100%, P > 0.05). When vitrified-warmed oocytes were first activated with 7% ethanol for 5 min and then incubated in 6-dimethylaminopurin (6-DMAP) for 4 h...... (for 5 min) or in combination with 6-DMAP (4 h) was used to activate vitrified-warmed oocytes, cleavage rates ranged from 22.3% to 61.1% and blastocyst rates ranged from 1.1% to 30.6%. These rates were optimized when oocytes were treated with 9% ethanol plus 6-DMAP; this was verified in experiments...

  13. WP EMPLACEMENT CONTROL AND COMMUNICATION EQUIPMENT DESCRIPTIONS

    International Nuclear Information System (INIS)

    Raczka, N.T.

    1997-01-01

    The objective and scope of this document are to list and briefly describe the major control and communication equipment necessary for waste package emplacement at the proposed nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the required equipment are explained and summarized in the individual subsections of this document. This task was evaluated in accordance with QAP-2-0 and found not to be quality affecting. Therefore, this document was prepared in accordance with NAP-MG-012. The following control and communication equipment are addressed in this document: (1) Programmable Logic Controllers (PLC's); (2) Leaky Feeder Radio Frequency Communication Equipment; (3) Slotted Microwave guide Communication Equipment; (4) Vision Systems; (5) Radio Control Equipment; and (6) Enclosure Cooling Systems

  14. Additive Construction with Mobile Emplacement (ACME)

    Science.gov (United States)

    Vickers, John

    2015-01-01

    The Additive Construction with Mobile Emplacement (ACME) project is developing technology to build structures on planetary surfaces using in-situ resources. The project focuses on the construction of both 2D (landing pads, roads, and structure foundations) and 3D (habitats, garages, radiation shelters, and other structures) infrastructure needs for planetary surface missions. The ACME project seeks to raise the Technology Readiness Level (TRL) of two components needed for planetary surface habitation and exploration: 3D additive construction (e.g., contour crafting), and excavation and handling technologies (to effectively and continuously produce in-situ feedstock). Additionally, the ACME project supports the research and development of new materials for planetary surface construction, with the goal of reducing the amount of material to be launched from Earth.

  15. Rannarootslaste suurmees Hans Pöhl / Olev Liivik

    Index Scriptorium Estoniae

    Liivik, Olev, 1975-

    2011-01-01

    Arvustus: Estlandssvenskarnas hövding. En biografi över Hans Pöhl (1876-1930), estlandssvenskarnas främste företrädare och ledare = Hans Pöhl - rannarootslaste eestvõileja : Hans Pöhl (1876-1930), Eesti rootslaste vaimse liidri ja valgustaja elulugu. Stockholm, 2010

  16. Probiotic assessment of Enterococcus durans 6HL and Lactococcus lactis 2HL isolated from vaginal microflora.

    Science.gov (United States)

    Nami, Yousef; Abdullah, Norhafizah; Haghshenas, Babak; Radiah, Dayang; Rosli, Rozita; Khosroushahi, Ahmad Yari

    2014-08-01

    Forty-five lactic acid bacteria (LAB) were isolated from the vaginal specimens of healthy fertile women, and the identities of the bacteria were confirmed by sequencing of their 16S rDNA genes. Among these bacteria, only four isolates were able to resist and survive in low pH, bile salts and simulated in vitro digestion conditions. Lactococcus lactis 2HL, Enterococcus durans 6HL, Lactobacillus acidophilus 36YL and Lactobacillus plantarum 5BL showed the best resistance to these conditions. These strains were evaluated further to assess their ability to adhere to human intestinal Caco-2 cells. Lactococcus lactis 2HL and E. durans 6HL were the most adherent strains. In vitro tests under neutralized pH proved the antimicrobial activity of both strains. Results revealed that the growth of Escherichia coli O26, Staphylococcus aureus and Shigella flexneri was suppressed by both LAB strains. The antibiotic susceptibility tests showed that these strains were sensitive to all nine antibiotics: vancomycin, tetracycline, ampicillin, penicillin, gentamicin, erythromycin, clindamycin, sulfamethoxazole and chloramphenicol. These data suggest that E. durans 6HL and Lactococcus lactis 2HL could be examined further for their useful properties and could be developed as new probiotics. © 2014 The Authors.

  17. TNTM85 and TNTM81 transports / storage flasks: An optimized solution for vitrified residues

    International Nuclear Information System (INIS)

    Sicard, D.; Verdier, A.; Dyck, P.

    2006-01-01

    By analyzing the evolution of burnup of spent fuel to be reprocessed, the high activity vitrified residues would not be transported in the existing flask designs. Therefore COGEMA LOGISTICS decided in the late nineties to develop a design with optimized capacity able to store and transport the most active and hottest canisters. The TN TM 85 flask shall permit in the near future in Germany the storage and the transport of the highest vitrified residues defining a thermal power of 56 kW. The challenge for the TN TM 85 flask design was that the geometry entry data were very restrictive and were combined with a fairly wide range set by COGEMA Specification 300AQ16 relative to vitrified residue canister. In addition, the cask had to fit as much as possible in the existing procedures for the TN TM 28 cask and TS 28 V cask, all along the logistics chain of loading, unloading, transport and maintenance. (authors)

  18. Hans Pöhl - Estlandssvenskarnas hövding = Hans Pöhl - rannarootslaste eestvõitleja / Torkel Jansson

    Index Scriptorium Estoniae

    Jansson, Torkel, 1947-

    2011-01-01

    Raamatututvustus: Hans Pöhl - Estlandssvenskarnas hövding : en biografi över Hans Pöhl (1876-1930), estlandssvenskarnas främste företrädare och ledare = Hans Pöhl - rannarootslaste eestvõitleja : Hans Pöhli (1876-1930), Eesti rootslaste vaimse liidri ja valgustaja elulugu. (Stockholm ; Tallinn, 2010)

  19. Ground Control for Non-Emplacement Drifts for LA

    International Nuclear Information System (INIS)

    Tang, D.

    2004-01-01

    The purpose of this calculation is to analyze the stability of repository non-emplacement drifts during the preclosure period, and to provide a final ground support method for non-emplacement drifts for the License Application (LA). This calculation will provide input for the development of LA documents. The scope of this calculation is limited to the non-emplacement drifts including access mains, ramps, exhaust mains, turnouts, intersections between access mains and turnouts, and intersections between exhaust mains and emplacement drifts, portals, TBM launch chambers, observation drift and test alcove in the performance confirmation (PC) facilities, etc. The calculation is limited to the non-emplacement drifts subjected to a combined loading of in-situ stress, seismic stress, and/or thermal stress. Other effects such as hydrological and chemical effects are not considered in this analysis

  20. Information dossier. Return of vitrified wastes from France to Belgium; Dossier d'information. Retour de dechets vitrifies depuis la France vers la Belgique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-02-01

    Synatom, a daughter company of Electrabel and Tractebel, is in charge of the fuel management of Belgium nuclear power plants. Contracts were signed with Cogema (France) in the 70's for the reprocessing/recycling of spent fuels. The ultimate residual wastes are vitrified at Cogema-La Hague and sent back to Belgium by rail and road transports. This information dossier presents: the power production in Belgium, the management of the fuel cycle in Belgium (recycling, interim storage of spent fuels at Tihange and Doel sites, political choices, financing), the vitrification process (quality assurance, safety), the transport of vitrified wastes from France to Belgium (handling, packaging, TN 28 VT container, regulations, safety evaluation), interim storage, long-term disposal. (J.S.)

  1. Relating rock avalanche morphology to emplacement processes

    Science.gov (United States)

    Dufresne, Anja; Prager, Christoph; Bösmeier, Annette

    2015-04-01

    The morphology, structure and sedimentological characteristics of rock avalanche deposits reflect both internal emplacement processes and external influences, such as runout path characteristics. The latter is mainly predisposed by topography, substrate types, and hydrogeological conditions. Additionally, the geological setting at the source slope controls, e.g. the spatial distribution of accumulated lithologies and hence material property-related changes in morphology, or the maximum clast size and amount of fines of different lithological units. The Holocene Tschirgant rock avalanche (Tyrol, Austria) resulted from failure of an intensely deformed carbonate rock mass on the southeast face of a 2,370-m-high mountain ridge. The initially sliding rock mass rapidly fragmented as it moved towards the floor of the Inn River valley. Part of the 200-250 x 106 m3 (Patzelt 2012) rock avalanche debris collided with and moved around an opposing bedrock ridge and flowed into the Ötz valley, reaching up to 6.3 km from source. Where the Tschirgant rock avalanche spread freely it formed longitudinal ridges aligned along motion direction as well as smaller hummocks. Encountering high topography, it left runup ridges, fallback patterns (i.e. secondary collapse), and compressional morphology (successively elevated, transverse ridges). Further evidence for the mechanical landslide behaviour is given by large volumes of mobilized valley-fill sediments (polymict gravels and sands). These sediments indicate both shearing and compressional faulting within the rock avalanche mass (forming their own morphological units through, e.g. in situ bulldozing or as distinctly different hummocky terrain), but also indicate extension of the spreading landslide mass (i.e. intercalated/injected gravels encountered mainly in morphological depressions between hummocks). Further influences on its morphology are given by the different lithological units. E.g. the transition from massive dolomite

  2. Performances of the HL (Hyperloop) transport system

    OpenAIRE

    van Goeverden, C.D.; Milakis, D.; Janic, M.; Konings, J.W.; Cools, M.; Limbourg, S.

    2017-01-01

    This paper deals with an analysis of performances of the HL (Hyperloop) transport system considered as an advanced transport alternative to the existing APT (Air Passenger Transport) and HSR (High Speed Rail) systems. The considered performances are operational, financial, social and environmental. The operational performance include capacity and quality of service provided to the system’s users-passengers with attributes such as door-to-door travel time consisting of the access and egress ti...

  3. HL-LHC updates in Japan

    CERN Multimedia

    Antonella Del Rosso

    2014-01-01

    At a recent meeting in Japan, updates on the High Luminosity LHC (HL-LHC) project were presented, including the progress made so far and the deadlines still to be met for the upgraded machine to be operational from 2020.   New magnets made with advanced superconductor Nb3Sn in the framework of the HL-LHC project. These magnets are currently under construction at CERN by the TE-MSC group. The LHC is the world’s most powerful particle accelerator, and in 2015 it will reach yet another new record for the energy of its colliding beams. One key factor of its discovery potential is its ability to produce collisions described in mathematical terms by the parameter known as “luminosity”. In 2025, the HL-LHC project will allow the total number of collisions in the LHC to increase by a factor of 10. The first step in this rich upgrade programme is the delivery of the Preliminary Design Report (PDR), which is also a key milestone of the HiLumi LHC Design Study partly fund...

  4. Overview of HL-2A experiment results

    International Nuclear Information System (INIS)

    Yang, Q.W.; Yong Liu; Ding, X.T.

    2007-01-01

    Recent experiment results from the HL-2A tokamak are presented in this paper. Supersonic molecular beam injection (SMBI) with liquid nitrogen temperature propellant is used. Low temperature SMBI can form hydrogen clusters that penetrate into the plasma more deeply and efficiently. Particle diffusion coefficient and convection velocity (D = 0.5-1.5 m 2 s -1 and V conv -1 , respectively) are obtained at the plasma periphery using modulated SMBI. Multi-probe measurements reveal the m = 0-1, n = 0 symmetries of directly measured low frequency (7-9 kHz) electric potential and field are simultaneously observed for the first time. Impurity transport is determined with the laser blow-off system and transport code. A disruption predictor has been derived based on MHD activity observations and statistical analysis. Sawtooth characteristics during ECRH are investigated and coupling between m = 1 and m/n = 2/1 modes is studied. Detachment features of HL-2A divertor are numerically and experimentally studied using the code SOLPS5.0 and measured data. The long divertor legs and thin divertor throats in HL-2A pose MHD shaping problems resulting in momentum losses even at low densities and strongly enhanced main chamber losses

  5. Review of potential subsurface permeable barrier emplacement and monitoring technologies

    International Nuclear Information System (INIS)

    Riggsbee, W.H.; Treat, R.L.; Stansfield, H.J.; Schwarz, R.M.; Cantrell, K.J.; Phillips, S.J.

    1994-02-01

    This report focuses on subsurface permeable barrier technologies potentially applicable to existing waste disposal sites. This report describes candidate subsurface permeable barriers, methods for emplacing these barriers, and methods used to monitor the barrier performance. Two types of subsurface barrier systems are described: those that apply to contamination.in the unsaturated zone, and those that apply to groundwater and to mobile contamination near the groundwater table. These barriers may be emplaced either horizontally or vertically depending on waste and site characteristics. Materials for creating permeable subsurface barriers are emplaced using one of three basic methods: injection, in situ mechanical mixing, or excavation-insertion. Injection is the emplacement of dissolved reagents or colloidal suspensions into the soil at elevated pressures. In situ mechanical mixing is the physical blending of the soil and the barrier material underground. Excavation-insertion is the removal of a soil volume and adding barrier materials to the space created. Major vertical barrier emplacement technologies include trenching-backfilling; slurry trenching; and vertical drilling and injection, including boring (earth augering), cable tool drilling, rotary drilling, sonic drilling, jetting methods, injection-mixing in drilled holes, and deep soil mixing. Major horizontal barrier emplacement technologies include horizontal drilling, microtunneling, compaction boring, horizontal emplacement, longwall mining, hydraulic fracturing, and jetting methods

  6. Theoretical-experimental comparison of vitrified glass container behavior using the Castem system

    International Nuclear Information System (INIS)

    Moncouyoux, J.P.; Jamet, P.; Combescure, A.; Millard, A.

    1989-01-01

    This paper compares theoretical predictions of vitrified nuclear waste glass package collapse with experimental values in order to qualify the mathematical models describing canister deformation under external pressure loads. After briefly outlining the program and describing the experiments performed, the paper discusses the theoretical predictions based on the INCA code from the CEA's CASTEM system

  7. Using depleted uranium to shield vitrified high-level waste packages

    International Nuclear Information System (INIS)

    Yoshimura, H.R.; Gildea, P.D.; Bernard, E.A.

    1995-01-01

    The underlying report for this paper evaluates options for using depleted uranium as shielding materials for transport systems for disposal of vitrified high-level waste (VHLW). In addition, economic analyses are presented to compare costs associated with these options to costs, associated with existing and proposed storage, transport, and diposal capabilities. A more detailed evaluation is provided elsewhere. (Yoshimura et al. 1995.)

  8. In-straw cryoprotectant dilution of IVP bovine blastocysts vitrified in hand-pulled glass micropipettes.

    Science.gov (United States)

    Vieira, A D; Forell, F; Feltrin, C; Rodrigues, J L

    2007-06-01

    The aim of this study was to determine the influence of two ethylene glycol-based vitrification solutions on in vitro and in vivo survival after in-straw cryoprotectant dilution of vitrified in vitro-produced bovine embryos. Day-7 expanded blastocysts were selected according to diameter (> or = 180 microm) and osmotic characteristics and randomly assigned to one of three groups (i) VSa: vitrification in 40% EG+17.1% SUC+0.1% PVA; (ii) VSb: vitrification in 20% EG+20% DMSO; (iii) control: non-vitrified embryos. Vitrification was performed in hand-pulled glass micropipettes (GMP) and cryoprotectant dilution in 0.25 ml straws after warming in a plastic tube. Embryo viability was assessed by re-expansion and hatching rates after 72 h of IVC and by pregnancy rates after direct transfer of vitrified embryos. No differences in re-expansion rates were observed between vitrified groups after 24 h in culture (VSa=84.5%; VSb=94.8%). However, fewer VSa embryos (55.2%, Pstraw cryoprotectant dilution and direct embryo transfer.

  9. Safety of handling, storing and transportation of spent nuclear fuel and vitrified high-level wastes

    International Nuclear Information System (INIS)

    Ericsson, A.M.

    1977-11-01

    The safety of handling and transportation of spent fuel and vitrified high-level waste has been studied. Only the operations which are performed in Sweden are included. That is: - Transportation of spent fuel from the reactors to an independant spent fuel storage installation (ISFSI). - Temporary storage of spent fuel in the ISFSI. - Transportation of the spent fuel from the ISFSI to a foreign reprocessing plant. - Transportation of vitrified high-level waste to an interim storage facility. - Interim storage of vitrified high-level waste. - Handling of the vitrified high-level waste in a repository for ultimate disposal. For each stage in the handling sequence above the following items are given: - A brief technical description. - A description of precautionary measures considered in the design. - An analysis of the discharges of radioactive materials to the environment in normal operation. - An analysis of the discharges of radioactive materials due to postulated accidents. The dose to the public has been roughly and conservatively estimated for both normal and accident conditions. The expected rate of occurence are given for the accidents. The results show that above described handling sequence gives only a minor risk contribution to the public

  10. Surface storage of vitrified high-level radioactive waste in reinforced-concrete casks

    International Nuclear Information System (INIS)

    Beale, H.; George, M.W.; Robertson, T.J.M.

    1982-06-01

    The feasibility of storing canisters containing vitrified high level radioactive waste in reinforced concrete casks is examined. This preliminary study identifies the limitations and probable cost of such a store and leads to the conclusion that the concept is feasible. (author)

  11. Waste package transfer, emplacement and retrievability in the French deep geological repository

    Energy Technology Data Exchange (ETDEWEB)

    Roulet, Alain; Delort, Daniel; Herve, Jean Francois; Bosgiraud, Jean Michel; Guenin, Jean Jacques [Technical Department ANDRA (France)

    2009-06-15

    Safe, reliable and reversible handling of waste is a significant issue related to the design and safety assessment of deep geological repository in France. The first step taken was to study various waste handling solutions. ANDRA also decided to fabricate and demonstrate industrial scale handling equipment for HLW (since 2003) and for ILW-LL wastes (since 2008). We will review the main equipment developed for the transfer process in the repository, for both types of waste, and underline the benefits of developing industrial demonstrators within the framework of international cooperation agreements. Waste retrieval capability will be simultaneously examined. Two types of waste have to be handled underground in Andra's repository. The HLW disposal package for vitrified waste is a 2 ton carbon steel cylindrical canister with a diameter of 600 mm. The weight of ILW-LL concrete disposal packages range from a minimum of 6 tonnes to over 20 tonnes, and their volume from approximately 5 to 10 m3. The underground transfer to the disposal drift requires moving the disposal package within a shielded transfer cask placed on a trailer. Transfer cask design has evolved since 2005, due to optimisation studies and as a result of industrial feedback from SKB. For HLW handling equipment two design options have been studied. In the first solution (Andra's Dossier 2005), the waste package are emplaced, one at a time, in the disposal drift by a pushing robot. Successive steps in design and proto-typing have lead to improve the design of the equipment and to gain confidence. Recently a fully integrated process has been successfully demonstrated, at full scale, (in a 100 m long mock up drift) as part of the EC funded ESDRED Project. This demonstrator is now on display in Andra's Technology Centre at Saudron, near the Bure Underground Laboratory. The second disposal option which has been investigated is based on a concept of utilising an external apparatus to push a row of

  12. Nornahraun lava morphology and mode of emplacement

    Science.gov (United States)

    Pedersen, Gro B. M.; Höskuldsson, Armann; Riishuus, Morten S.; Jónsdóttir, Ingibjörg; Gudmundsson, Magnús T.; Sigmundsson, Freysteinn; Óskarsson, Birgir V.; Drouin, Vincent; Gallagher, Catherine; Askew, Rob; Moreland, William M.; Dürig, Tobias; Dumont, Stephanie; Þórdarson, Þór

    2015-04-01

    The ongoing Nornahraun eruption is the largest effusive eruption in Iceland since the Laki eruption in 1783-84, with an estimated lava volume of ~1.15 km3 covering an area of ~83.4 km2 (as of 5 JAN 2015). The eruption provides an unprecedented opportunity to study i) lava morphologies and their emplacement styles, ii) the transition from from open to closed lava pathways and iii) lava pond formation. Tracking of the lava advancement and morphology has been performed by GPS and GoPro cameras installed in 4×4 vehicles as well as video footage. Complimentary observations have been provided from aircraft platforms and by satellite data. Of particular importance for lava morphology observations are 1-12 m/pixel airborne SAR images (x-band). The Nornahraun flow field comprises a continuum of morphologies from pāhoehoe to 'a'ā, which have varied tem-porally and spatially. At the onset of the eruption 31 AUG, lava flows advanced rapidly (400-800 m/hr) from the 1.5 km long fissure as large slabby pāhoehoe [1-3] sheet lobes, 100-500 m wide and 0.3-1 m thick at the flow fronts. By 1 SEPT, the flows began channeling towards the NE constrained by the older Holuhraun I lava field and the to-pography of flood plain itself. A central open channel developed, feeding a 1-2 km wide active 'a'ā frontal lobe that advanced 1-2 km/day. In addition to its own caterpillar motion, the frontal lobe advanced in a series of 30-50 m long breakouts, predominantly slabby and rubbly pāhoehoe [4,5]. These breakouts had initial velocities of 10-30 m/hr and reached their full length within tens of minutes and subsequently inflated over hours. With the continuous advancement of the 'a'ā flow front, the breakouts were incorporated into the 'a'ā flow fronts and seldom preserved. At the margins of the frontal lava lobe, the breakouts were more sporadic, but predominantly rubbly pāhoehoe and slabby pāhoehoe, as at the flow front. The lava flow advanced ENE into Jökulsá á Fjöllum on 7 SEPT

  13. Rootless tephra stratigraphy and emplacement processes

    Science.gov (United States)

    Hamilton, Christopher W.; Fitch, Erin P.; Fagents, Sarah A.; Thordarson, Thorvaldur

    2017-01-01

    Volcanic rootless cones are the products of thermohydraulic explosions involving rapid heat transfer from active lava (fuel) to external sources of water (coolant). Rootless eruptions are attributed to molten fuel-coolant interactions (MFCIs), but previous studies have not performed systematic investigations of rootless tephrostratigraphy and grain-size distributions to establish a baseline for evaluating relationships between environmental factors, MFCI efficiency, fragmentation, and patterns of tephra dispersal. This study examines a 13.55-m-thick vertical section through an archetypal rootless tephra sequence, which includes a rhythmic succession of 28 bed pairs. Each bed pair is interpreted to be the result of a discrete explosion cycle, with fine-grained basal material emplaced dominantly as tephra fall during an energetic opening phase, followed by the deposition of coarser-grained material mainly as ballistic ejecta during a weaker coda phase. Nine additional layers are interleaved throughout the stratigraphy and are interpreted to be dilute pyroclastic density current (PDC) deposits. Overall, the stratigraphy divides into four units: unit 1 contains the largest number of sediment-rich PDC deposits, units 2 and 3 are dominated by a rhythmic succession of bed pairs, and unit 4 includes welded layers. This pattern is consistent with a general decrease in MFCI efficiency due to the depletion of locally available coolant (i.e., groundwater or wet sediments). Changing conduit/vent geometries, mixing conditions, coolant and melt temperatures, and/or coolant impurities may also have affected MFCI efficiency, but the rhythmic nature of the bed pairs implies a periodic explosion process, which can be explained by temporary increases in the water-to-lava mass ratio during cycles of groundwater recharge.

  14. Improvements relating to apparatus for emplacing or replacing a gaiter

    International Nuclear Information System (INIS)

    Chilvers, D.; Morrison, D.M.

    1982-01-01

    The invention relates to apparatus for emplacing or replacing a gaiter of the type which may be used in sealing the hot side of an isolation enclosure which is associated with a master-slave manipulator. (author)

  15. Von Hippel-Lindau disease (vHL)

    DEFF Research Database (Denmark)

    Binderup, Marie Louise Mølgaard; Bisgaard, Søs Marie Luise; Harbud, Vibeke

    2013-01-01

    These clinical guidelines outline the criteria and recommendations for diagnostic and genetic work-up of families suspected of von Hippel-Lindau disease (vHL), as well as recommendations for prophylactic surveillance for vHL patients. The guideline has been composed by the Danish Coordination Group...... for vHL which is comprised of Danish doctors and specialists interested in vHL. The recommendations are based on longstanding clinical experience, Danish original research, and extensive review of the international literature. vHL is a hereditary multi-tumour disease caused by germline mutations...... of the disease, and/or in individuals with a vHL-associated manifestation; i.e. a hemangioblastoma in the retina or the central nervous system, familial or bilateral pheochromocytomas, familial, multiple, or early onset renal cell carcinomas, and in individuals with an endolymphatic sac tumour in the inner ear...

  16. Optics Measurements and Correction Challenges for the HL-LHC

    CERN Document Server

    Carlier, Felix Simon; Fartoukh, Stephane; Fol, Elena; Gamba, Davide; Garcia-Tabares Valdivieso, Ana; Giovannozzi, Massimo; Hofer, Michael; Langner, Andy Sven; Maclean, Ewen Hamish; Malina, Lukas; Medina Medrano, Luis Eduardo; Persson, Tobias Hakan Bjorn; Skowronski, Piotr Krzysztof; Tomas Garcia, Rogelio; Van Der Veken, Frederik; Wegscheider, Andreas

    2017-01-01

    Optics control in the HL-LHC will be challenged by a very small β* of 15 cm in the two main experiments. HL-LHC physics fills will keep a constant luminosity during several hours via β* leveling. This will require the commissioning of a large number of optical configurations, further challenging the efficiency of the optics measurements and correction tools. We report on the achieved level of optics control in the LHC with simulations and extrapolations for the HL-LHC.

  17. HL-LHC kicker magnet (MKI)

    CERN Multimedia

    Brice, Maximilien

    2018-01-01

    HL-LHC kicker magnet (MKI): last vacuum test, preparation for transport to LHC transfer line in underground tunnel.The LHC injection kicker systems (MKIs) generate fast field pulses to inject the clockwise rotating beam at Point 2 and the anti-clockwise rotating beam at Point 8: there are eight MKI magnets installed in total. Each MKI magnet contains a high purity alumina tube: if an MKI magnet is replaced this tube requires conditioning with LHC beam: until it is properly conditioned, there can be high vacuum pressure due to the beam. This high pressure can also cause electrical breakdowns in the MKI magnets. A special coating (Cr2O3) has been applied to the inside of the alumina tube of an upgraded MKI magnet – this is expected to greatly reduce the pressure rise with beam. In addition, HL-LHC beam would result in excessive heating of the MKI magnets: the upgraded design includes modifications that will reduce heating, and move the power deposition to parts that will be easier to cool. Experience during 2...

  18. Introduction to the HL-LHC Project

    Science.gov (United States)

    Rossi, L.; Brüning, O.

    The Large Hadron Collider (LHC) is one of largest scientific instruments ever built. It has been exploring the new energy frontier since 2010, gathering a global user community of 7,000 scientists. To extend its discovery potential, the LHC will need a major upgrade in the 2020s to increase its luminosity (rate of collisions) by a factor of five beyond its design value and the integrated luminosity by a factor of ten. As a highly complex and optimized machine, such an upgrade of the LHC must be carefully studied and requires about ten years to implement. The novel machine configuration, called High Luminosity LHC (HL-LHC), will rely on a number of key innovative technologies, representing exceptional technological challenges, such as cutting-edge 11-12 tesla superconducting magnets, very compact superconducting cavities for beam rotation with ultra-precise phase control, new technology for beam collimation and 300-meter-long high-power superconducting links with negligible energy dissipation. HL-LHC federates efforts and R&D of a large community in Europe, in the US and in Japan, which will facilitate the implementation of the construction phase as a global project.

  19. Introduction to the HL-LHC Project

    CERN Document Server

    Rossi , L

    2015-01-01

    The Large Hadron Collider (LHC) is one of largest scientific instruments ever built. It has been exploring the new energy frontier since 2010, gathering a global user community of 7,000 scientists. To extend its discovery potential, the LHC will need a major upgrade in the 2020s to increase its luminosity (rate of collisions) by a factor of five beyond its design value and the integrated luminosity by a factor of ten. As a highly complex and optimized machine, such an upgrade of the LHC must be carefully studied and requires about ten years to implement. The novel machine configuration, called High Luminosity LHC (HL-LHC), will rely on a number of key innovative technologies, representing exceptional technological challenges, such as cutting-edge 11–12 tesla superconducting magnets, very compact superconducting cavities for beam rotation with ultra-precise phase control, new technology for beam collimation and 300-meter-long high-power superconducting links with negligible energy dissipation. HL-LHC federa...

  20. Longevity of Emplacement Drift Ground Support Materials, Rev. 01

    International Nuclear Information System (INIS)

    David H. Tang

    2000-01-01

    The purpose of this analysis is to evaluate the factors affecting the longevity of emplacement drift ground support materials and to develop a basis for the selection of materials for ground support that will function throughout the preclosure period of a potential repository at Yucca Mountain. The Development Plan (DP) for this analysis is given in Longevity of Emplacement Drift Ground Support Materials (CRWMS M and O 1999a). The objective of this analysis is to update the previous analysis (CRWMS M and O 2000a) to account for related changes in the Ground Control System Description Document (CRWMS M and O 2000b), the Monitored Geologic Repository Project Description Document (CRWMS M and O 1999b), and in environmental conditions, and to provide updated information on candidate ground support materials. Candidate materials for ground support are carbon steel and cement grout. Steel is mainly used for steel sets, lagging, channel, rock bolts, and wire mesh. Cement grout is only considered in the case of grouted rock bolts. Candidate materials for the emplacement drift invert are carbon steel and crushed rock ballast. Materials are evaluated for the repository emplacement drift environment based on the updated thermal loading condition and waste package design. The analysis consists of the following tasks: (1) Identify factors affecting the longevity of ground support materials for use in emplacement drifts; (2) Review existing documents concerning the behavior of candidate ground support materials during the preclosure period; (3) Evaluate impacts of temperature and radiation effects on mechanical and thermal properties of steel. Assess corrosion potential of steel at emplacement drift environment; (4) Evaluate factors affecting longevity of cement grouts for fully grouted rock bolt system. Provide updated information on cement grout mix design for fully grouted rock bolt system; and (5) Evaluate longevity of materials for the emplacement drift invert

  1. Emplacement and stemming of nuclear explosives for Plowshare applications

    International Nuclear Information System (INIS)

    Cramer, J.L.

    1970-01-01

    This paper will discuss the various methods used for emplacement and design considerations that must be taken into account when the emplacement and stemming method is selected. The step-by-step field procedure will not be discussed in this paper. The task of emplacing and stemming the nuclear explosive is common to all Plowshare experiments today. All present-day applications of a nuclear explosive for Plowshare experiments require that the detonation take place some distance below the surface of the ground. This is normally done by lowering the explosive into an emplacement hole to a desired depth and then backfilling the hole with a suitable stemming material. At first glance it scenes like a very straightforward, simple task to perform. It would appear to be a task that could become a standard procedure for all experiments; however, this is not the case. In actuality, the emplacement and stemming of a nuclear explosive must almost be a custom design. It varies with the application of the experiment, i.e., cratering or underground engineering. It also varies with the condition of the hole, the available equipment to do the job, the actual purpose of the stemming, possible postshot reentry, hydrology, geology, and future production. A very important item that must always be considered is the protection of the firing and signal cables during the downhole and stemming operation. Each of these things must be considered; ignoring any one of them could jeopardize one of the objectives of the experiment or perhaps even the experiment itself. It should be emphasized that for a multiple-shot program such as would be used to develop a gas field where the geology, depths of burial etc. are the same, the emplacement and stemming operation would be standardized, as would all other parts of the program. However, for individual experiments in totally different areas, complete standardization of the emplacement and stemming is impossible

  2. Emplacement and stemming of nuclear explosives for Plowshare applications

    Energy Technology Data Exchange (ETDEWEB)

    Cramer, J L [Lawrence Radiation Laboratory, University of California, Livermore, CA (United States)

    1970-05-15

    This paper will discuss the various methods used for emplacement and design considerations that must be taken into account when the emplacement and stemming method is selected. The step-by-step field procedure will not be discussed in this paper. The task of emplacing and stemming the nuclear explosive is common to all Plowshare experiments today. All present-day applications of a nuclear explosive for Plowshare experiments require that the detonation take place some distance below the surface of the ground. This is normally done by lowering the explosive into an emplacement hole to a desired depth and then backfilling the hole with a suitable stemming material. At first glance it scenes like a very straightforward, simple task to perform. It would appear to be a task that could become a standard procedure for all experiments; however, this is not the case. In actuality, the emplacement and stemming of a nuclear explosive must almost be a custom design. It varies with the application of the experiment, i.e., cratering or underground engineering. It also varies with the condition of the hole, the available equipment to do the job, the actual purpose of the stemming, possible postshot reentry, hydrology, geology, and future production. A very important item that must always be considered is the protection of the firing and signal cables during the downhole and stemming operation. Each of these things must be considered; ignoring any one of them could jeopardize one of the objectives of the experiment or perhaps even the experiment itself. It should be emphasized that for a multiple-shot program such as would be used to develop a gas field where the geology, depths of burial etc. are the same, the emplacement and stemming operation would be standardized, as would all other parts of the program. However, for individual experiments in totally different areas, complete standardization of the emplacement and stemming is impossible.

  3. Feasibility study on utilization of vitrified radioactive waste as radiation sources

    International Nuclear Information System (INIS)

    Makuuchi, Keizo; Yoshii, Fumio; Hyakutake, Kenichiro

    1995-01-01

    A feasibility study on utilization of vitrified high level radioactive waste (VW) as radiation source has been carried out. Natural rubber latex was radiation vulcanized with VW to demonstrate the feasibility. The dose rate was 0.1 kGy/hr. As a sensitizer, n-butyl acrylate was added. Negligible small activation of natural rubber (NR) latex by neutron from the VW was observed. The residual sensitizer in the irradiated latex and physical properties of film molded from the irradiated latex were the same level with the conventional radiation vulcanization of NR latex with γ-rays from Co-60. Surgical gloves and protective rubber gloves for radioactive contamination were produced from 20 litters of NR latex vulcanized with 2 VWs. The physical properties of both gloves were acceptable. These results suggested that vitrified high level waste can be used as an industrial radiation source. (author)

  4. Technology survey for real-time monitoring of plutonium in a vitrifier off-gas system

    International Nuclear Information System (INIS)

    Berg, J.M.; Veirs, D.K.

    1996-01-01

    We surveyed several promising measurement technologies for the real-time monitoring of plutonium in a vitrifier off-gas system. The vitrifier is being developed by Westinghouse Savannah River Corp. and will be used to demonstrate vitrification of plutonium dissolved in nitric acid for fissile material disposition. The risk of developing a criticality hazard in the off-gas processing equipment can be managed by using available measurement technologies. We identified several potential technologies and methods for detecting plutonium that are sensitive enough to detect the accumulation of a mass sufficient to form a criticality hazard. We recommend gross alpha-monitoring technologies as the most promising option for Westinghouse Savannah River Corp. to consider because that option appears to require the least additional development. We also recommend further consideration for several other technologies because they offer specific advantages and because gross alpha-monitoring could prove unsuitable when tested for this specific application

  5. Thermal test and analysis for transporting vitrified high-level radioactive wastes

    International Nuclear Information System (INIS)

    Yamakawa, H.; Gomi, Y.; Ozaki, S.; Kato, O.; Tamaki, H.

    1993-01-01

    As a part of the safety demonstration tests for transport casks of high level radioactive vitrified wastes, the thermal tests of the cask (left unattended at an ambient temperature of 38degC for a period of one week) were executed before and after the side free drop test (from height of 30 cm). This condition was set according to the prospect of the damage of contents (baskets, etc.) by the impact force at the drop test. It was shown that the cask temperatures at the representative parts, such as the vitrified wastes, the containment system, and the protection wire net, were lower than allowable values. From the result of measured temperatures it was considered that no damages and no large deformations could happen to the contents in this drop test. Thermal analysis was also done to establish the analysis model. (J.P.N.)

  6. Handling and Emplacement Options for Deep Borehole Disposal Conceptual Design.

    Energy Technology Data Exchange (ETDEWEB)

    Cochran, John R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hardin, Ernest [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-07-01

    This report presents conceptual design information for a system to handle and emplace packages containing radioactive waste, in boreholes 16,400 ft deep or possibly deeper. Its intended use is for a design selection study that compares the costs and risks associated with two emplacement methods: drill-string and wireline emplacement. The deep borehole disposal (DBD) concept calls for siting a borehole (or array of boreholes) that penetrate crystalline basement rock to a depth below surface of about 16,400 ft (5 km). Waste packages would be emplaced in the lower 6,560 ft (2 km) of the borehole, with sealing of appropriate portions of the upper 9,840 ft (3 km). A deep borehole field test (DBFT) is planned to test and refine the DBD concept. The DBFT is a scientific and engineering experiment, conducted at full-scale, in-situ, without radioactive waste. Waste handling operations are conceptualized to begin with the onsite receipt of a purpose-built Type B shipping cask, that contains a waste package. Emplacement operations begin when the cask is upended over the borehole, locked to a receiving flange or collar. The scope of emplacement includes activities to lower waste packages to total depth, and to retrieve them back to the surface when necessary for any reason. This report describes three concepts for the handling and emplacement of the waste packages: 1) a concept proposed by Woodward-Clyde Consultants in 1983; 2) an updated version of the 1983 concept developed for the DBFT; and 3) a new concept in which individual waste packages would be lowered to depth using a wireline. The systems described here could be adapted to different waste forms, but for design of waste packaging, handling, and emplacement systems the reference waste forms are DOE-owned high- level waste including Cs/Sr capsules and bulk granular HLW from fuel processing. Handling and Emplacement Options for Deep Borehole Disposal Conceptual Design July 23, 2015 iv ACKNOWLEDGEMENTS This report has

  7. Metabolic changes in droplet vitrified semen of wild endangered Persian sturgeon Acipenser persicus (Borodin, 1997).

    Science.gov (United States)

    Abed-Elmdoust, Amirreza; Farahmand, Hamid; Mojazi-Amiri, Bagher; Rafiee, Gholamreza; Rahimi, Ruhollah

    2017-06-01

    Comparative quantitative metabolite profiling can be used for better understanding of cell functions and dysfunctions in particular circumstances such as sperm banking which is an important approach for cryopreservation of endangered species. Cryopreservation techniques have some deleterious effects on spermatozoa which put the obtained results in controversy. Therefore, in the present study, quantitative 1 H NMR (Nuclear Magnetic Resonance) based metabolite profiling was conducted to evaluate metabolite changes related to energetics and some other detected metabolites in vitrified semen of critically endangered wild Acipenser persicus. The semen was diluted with extenders containing 0, 5, 10, and 15 μM of fish antifreeze protein (AFP) type III as a cryoprotectant. Semen-extenders were vitrified and stored for two days. Based on post-thaw motility duration and motility percentage assessments, two treatments with 10 μM and 0 μM of AFP had the highest and the lowest motility percentages respectively and they were objected to 1 H NMR spectroscopy investigations in order to reveal the extremes of the metabolites dynamic range. Univariate (ANOVA) and multivariate (PCA) analysis of the resulting metabolic profiles indicated significant changes (P > 0.05) in metabolites. The level of some metabolites including acetate, adenine, creatine, creatine phosphate, lactate, betaine, sarcosine, β-alanine and trimethylamine N-oxide significantly decreased in vitrified semen while some others such as creatinine, guanidinoacetate, N, N-dimethylglycine, and glycine significantly increased. There were also significant differences between vitrified treatments in levels of creatine, creatine phosphate, creatinine, glucose, guanidinoacetate, lactate, N, N-dimethylglycine, and glycine, suggesting how fish AFP type III can be effective as a cryoprotectant. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Handling of spent nuclear fuel and final storage of vitrified high level reprocessing waste

    International Nuclear Information System (INIS)

    1978-01-01

    The report gives a general summary of the Swedish KBS-project on management and disposal of vitrified reprocessed waste. Its final aim is to demostrate that the means of processing and managing power reactor waste in an absolutely safe way, as stipulated in the Swedish so called Conditions Act, already exist. Chapters on Storage facility for spent fuel, Intermidiate storage of reprocessed waste, Geology, Final repository, Transportation, Protection, and Siting. (L.E.)

  9. Handling of spent nuclear fuel and final storage of vitrified high level reprocessing waste

    International Nuclear Information System (INIS)

    1978-01-01

    A summary of the planning of transportation and plant design in the Swedish KBS project on management and disposal reprocessed radioactive waste. It describes a transportation system, a central storage facility for used fuel elements, a plant for intermediate storage and encapsulation and a final repository for the vitrified waste. Accounts are given for the reprocessing and vitrification. The safety of the entire system is discussed

  10. WIPP waste package testing on simulated DHLW: emplacement

    International Nuclear Information System (INIS)

    Molecke, M.A.

    1984-01-01

    Several series of simulated (nonradioactive) defense high-level waste (DHLW) package tests have been emplaced in the WIPP, a research and development facility authorized to demonstrate the safe disposal of defense-related wastes. The primary purpose of these 3-to-7 year duration tests is to evaluate the in situ materials performance of waste package barriers (canisters, overpacks, backfills, and nonradioactive DHLW glass waste form) for possible future application to a licensed waste repository in salt. This paper describes all test materials, instrumentation, and emplacement and testing techniques, and discusses progress of the various tests. These tests are intended to provide information on materials behavior (i.e., corrosion, metallurgical and geochemical alterations, waste form durability, surface interactions, etc.), as well as comparison between several waste package designs, fabrications details, and actual costs. These experiments involve 18 full-size simulated DHLW packages (approximately 3.0 m x 0.6 m diameter) emplaced in vertical boreholes in the salt drift floor. Six of the test packages contain internal electrical heaters (470 W/canister), and were emplace under approximately reference DHLW repository conditions. Twelve other simulated DHLW packages were emplaced under accelerated-aging or overtest conditions, including the artificial introduction of brine, and a thermal loading approximately three to four times higher than reference. Eight of these 12 test packages contain 1500 W/canister electrical heaters; the other four are filled with DHLW glass. 9 refs., 1 fig

  11. Preliminary results of MHD stability in HL-1 tokamak

    International Nuclear Information System (INIS)

    Zheng Yongzhen; Ma Tengcai; Xiao Zhenggui Cai Renfang

    1987-01-01

    In this paper, MHD activities of HL-1 tokamak plasma are studied with Fourier transform and correlatio analysis. The poloidal modes m = 1, 2, 3,4 and toroidal modes n of MHD magnetic fluctuation signals are detected. Methods for suppressing MHD instabilities are suggested and tested, after MHD instabilities are studied in HL-1. The effects of MHD characteristics in the beginning stage of discharge on the whole process of discharge are analyzed. The disruption, in HL-1 device could be divided into three kinds: internal disruption, minor disruption and major disruption. The result shows that HL-1 will have a better operation condition if internal disruption appears. In is end, the stable operation region of HL-1 tokamak is also given

  12. CHARACTERIZATION OF VITRIFIED SAVANNAH RIVER SITE SB4 WASTE SURROGATE PRODUCED IN COLD CRUCIBLE

    International Nuclear Information System (INIS)

    Marra, J

    2008-01-01

    Savannah River Site (SRS) sludge batch 4 (SB4) waste surrogate with high aluminum and iron content was vitrified with commercially available Frit 503-R4 (8 wt.% Li 2 O, 16 wt.% B2O3, 76 wt.% SiO 2 ) by cold crucible inductive melting using lab- (56 mm inner diameter), bench- (236 mm) and large-scale (418 mm) cold crucible. The waste loading ranged between 40 and 60 wt.%. The vitrified products obtained in the lab-scale cold crucible were nearly amorphous with traces of unreacted quartz in the product with 40 wt.% waste loading and traces of spinel phase in the product with 50 wt.% waste loading. The glassy products obtained in the bench-scale cold crucible are composed of major vitreous and minor iron-rich spinel phase whose content at ∼60 wt.% waste loading may achieve ∼10 vol.%. The vitrified waste obtained in the large-scale cold crucible was also composed of major vitreous and minor spinel structure phases. No nepheline phase has been found. Average degree of crystallinity was estimated to be ∼12 vol.%. Anionic motif of the glass network is built from rather short metasilicate chains and boron-oxygen constituent based on boron-oxygen triangular units

  13. Stabilization of vitrified wastes: Task 4. Topical report, October 1994--September 1995

    International Nuclear Information System (INIS)

    Nowok, J.W.; Pflughoeft-Hassett, D.F.; Hassett, D.J.; Hurley, J.P.

    1995-09-01

    The goal of this task was to work with private industry to refine existing vitrification processes to produce a more stable vitrified product. The initial objectives were to (1) demonstrate a waste vitrification procedure for enhanced stabilization of waste materials and (2) develop a testing protocol to understand the long-term leaching behavior of the stabilized waste form. The testing protocol was expected to be based on a leaching procedure called the synthetic groundwater leaching procedure (SGLP). This task will contribute to the US DOE's identified technical needs in waste characterization, low-level mixed-waste processing, disposition technology, and improved waste forms. The proposed work was to proceed over 4 years in the following steps: literature surveys to aid in the selection and characterization of test mixtures for vitrification, characterization of optimized vitrified test wastes using advanced leaching protocols, and refinement and demonstration of vitrification methods leading to commercialization. For this year, literature surveys were completed, and computer modeling was performed to determine the feasibility of removing heavy metals from a waste during vitrification, thereby reducing the hazardous nature of the vitrified material and possibly producing a commercial metal concentrate. This report describes the following four subtasks: survey of vitrification technologies; survey of cleanup sites; selection and characterization of test mixtures for vitrification and crystallization; and selection of crystallization methods based on thermochemistry modeling

  14. Neonatal health including congenital malformation risk of 1072 children born after vitrified embryo transfer.

    Science.gov (United States)

    Belva, F; Bonduelle, M; Roelants, M; Verheyen, G; Van Landuyt, L

    2016-07-01

    Does vitrification of Day 3 and Day 5 embryos adversely affect birth outcomes of singletons and twins in comparison with peers born after fresh embryo transfer? Neonatal health parameters, including the prevalence of congenital malformations, in singletons and twins born after embryo vitrification are similar to or slightly better than after fresh embryo transfer. Although vitrification, rather than slow-freezing, of embryos is routine practice nowadays, convincing evidence regarding the safety for the offspring is sparse. Literature data comprise results from mostly small-sized studies or studies including only Day 3 or only Day 5 vitrified embryo transfers. Overall, better or comparable perinatal outcomes, in terms of higher birthweight and lower risk for small-for-gestational age or for low birthweight, have been reported for singletons born after vitrified embryo transfer compared with fresh embryo transfer. According to the single available study with sufficient sample size, the congenital malformation rate was found to be comparable after vitrified and fresh embryo transfers. Data were collected from 960 cycles after transfer of embryos vitrified on Day 3 (n = 457) or Day 5 (n = 503) and from 1644 cycles after fresh embryo transfer on Day 3 (n = 853) or Day 5 (n = 791), performed between 2008 and 2013 at the Centre for Reproductive Medicine of the university hospital UZ Brussel. Outcome measures were neonatal health in terms of birthweight, small-for-gestational age, prematurity rate, perinatal death and major/minor/total malformation rate. Perinatal health parameters of 11 stillborns and 1061 live borns (827 singletons and 234 twins) in the vitrified group and of 28 stillborns and 1838 live borns (1374 singletons and 464 twins) in the fresh embryo group are reported. Within 3 months after birth, children in the two study groups were assessed clinically with special attention to congenital malformations by a paediatrician blinded to the type of embryo

  15. Permeability of granular beds emplaced in vertical drill holes

    International Nuclear Information System (INIS)

    Griffiths, S.K.; Morrison, F.A. Jr.

    1979-01-01

    To determine the permeabilities of granular materials emplaced in vertical drill holes used for underground nuclear tests, an experiment at the USDOE Nevada Test Site (NTS) was conducted. As the hole is being filled, falling material increases pressure above and within the granular beds beneath. When the filling operation starts or stops, a transient pressure response occurs within the beds; measurements of this response in beds of various compositions were made. The permeabilities after emplacement were found by matching analytical predictions of the response to these data. This information is useful in assuring the containment of nuclear tests conducted in such drill holes

  16. Effect of coumarins on HL-60 cell differentiation.

    Science.gov (United States)

    Kawaii, S; Tomono, Y; Katase, E; Ogawa, K; Yano, M

    2000-01-01

    Twenty-eight coumarins, including 7 furocoumarins, were examined for their activity of induction of terminal differentiation of human promyelocytic leukemia cells (HL-60) by nitro blue tetrazolium (NBT) reducing, nonspecific esterase, specific esterase and phagocytic activities. Esculetin, nordalbergin, 6,7-dihydroxy-4-methylcoumarin and imperatorin had strong activity among the coumarins examined. HL-60 cells treated with these coumarins differentiated into mature monocyte/macrophage. The structure-activity relationship established from the results revealed that 6,7-dihydroxy moiety had an important role in the induction of differentiation of HL-60.

  17. Von Hippel-Lindau disease (vHL)

    DEFF Research Database (Denmark)

    Binderup, Marie Louise Mølgaard; Bisgaard, Søs Marie Luise; Harbud, Vibeke

    2013-01-01

    for vHL which is comprised of Danish doctors and specialists interested in vHL. The recommendations are based on longstanding clinical experience, Danish original research, and extensive review of the international literature. vHL is a hereditary multi-tumour disease caused by germline mutations....../MRI of the abdomen, e) annual plasma-metanephrine, plasma-normetanephrine, and plasma-chromogranin A tests, and f) annual hearing examination at a department of audiology. It is advised that one doctor takes on the responsibility of coordination of and referral to the many examinations, and the communication...

  18. Effect of repository underground ventilation on emplacement drift temperature control

    International Nuclear Information System (INIS)

    Yang, H.; Sun, Y.; McKenzie, D.G.; Bhattacharyya, K.K.

    1996-01-01

    The repository advanced conceptual design (ACD) is being conducted by the Civilian Radioactive Waste Management System, Management ampersand Operating Contractor. Underground ventilation analyses during ACD have resulted in preliminary ventilation concepts and design methodologies. This paper discusses one of the recent evaluations -- effects of ventilation on emplacement drift temperature management

  19. Salt Repository Project waste emplacement mode decision paper: Revison 1

    International Nuclear Information System (INIS)

    1987-08-01

    This paper provides a recommendation as to the mode of waste emplacement to be used as the current basis for site characterization activity for the Deaf Smith County, Texas, high level nuclear waste repository site. It also presents a plan for implementing the recommendation so as to provide a high level of confidence in the project's success. Since evaluations of high-level waste disposal in geologic repositories began in the 1950s, most studies emplacement in salt formations employed the vertical orientation for emplacing waste packages in boreholes in the floor of the underground facility. This orientation was used in trials at Project Salt Vault in the 1960s. The Waste Isolation Pilot Plant (WIPP) has recently settled on a combination of vertical and horizontal modes for various waste types. This paper analyzes the information available and develops a project position upon which to base current site characterization activities. The position recommended is that the SRP should continue to use the vertical waste emplacement mode as the reference design and to carry the horizontal mode as a ''passive'' alternative. This position was developed based upon the conclusions of a decision analysis, risk assessment, and cost/schedule impact assessment. 52 refs., 6 figs., 1 tab

  20. Dieter Möhl (1936–2012)

    CERN Multimedia

    2012-01-01

    It is with great emotion and deep sadness that we learnt of the loss of our colleague and friend Dieter Möhl on 24 May. An accelerator physicist of world reputation, he made essential contributions to many projects at CERN and around the world. Here at CERN his name will remain forever linked with the success of the antiproton programme from its very beginning, but he also made substantial contributions to the FAIR project in Germany and to many other storage rings where beam cooling was an essential ingredient. His theoretical work was unique for the understanding, improvement and extension of beam cooling techniques to many accelerators and storage rings.   He was one of the pioneers who demonstrated by the Initial Cooling Experiment (ICE) that stochastic cooling was a viable proposition. This was essential for the approval of the CERN antiproton programme and its success.  Then, he was a leading member of the team which initiated and designed the Low Energy Antiproton Rin...

  1. Machine Protection Challenges for HL-LHC

    CERN Document Server

    Schmidt, R; Wenninger, J; Wollmann, D; Zerlauth, M

    2014-01-01

    LHC operation requires the flawless functioning of the machine protection systems. The energy stored in the beam was progressively increased beyond the 140 MJ range at the end of 2012 at 4 TeV/c. The further increase to more than 300 MJ expected for 2015 at 6.5 TeV/c should be possible with the existing protection systems. For HL-LHC additional failure modes need to be considered. The stored beam energy will increase by another factor of two with respect to nominal and a factor of five more than experienced so far. The maximum beta function in the high luminosity insertion regions will increase. It is planned to install crab cavities in the LHC to compensate for the loss in luminosity due to the crossing-angle. With crab cavities, sudden voltage decays within 100 µs after e.g. cavity quenches can lead to large transverse beam oscillations. Tracking simulations predict trajectory distortions of up to 1.5 σ after a sudden drop of the deflecting voltage in a single cavity. Protons in the halo with an energy of...

  2. Prototype HL-LHC magnet undergoes testing

    CERN Multimedia

    Corinne Pralavorio

    2016-01-01

    A preliminary short prototype of the quadrupole magnets for the High-Luminosity LHC has passed its first tests.   The first short prototype of the quadrupole magnet for the High Luminosity LHC. (Photo: G. Ambrosio (US-LARP and Fermilab), P. Ferracin and E. Todesco (CERN TE-MSC)) Momentum is gathering behind the High-Luminosity LHC (HL-LHC) project. In laboratories on either side of the Atlantic, a host of tests are being carried out on the various magnet models. In mid-March, a short prototype of the quadrupole magnet underwent its first testing phase at the Fermilab laboratory in the United States. This magnet is a pre-prototype of the quadrupole magnets that will be installed near to the ATLAS and CMS detectors to squeeze the beams before collisions. Six quadrupole magnets will be installed on each side of each experiment, giving a total of 24 magnets, and will replace the LHC's triplet magnets. Made of superconducting niobium-tin, the magnets will be more powerful than their p...

  3. Physics design of the HL-2A tokamak

    International Nuclear Information System (INIS)

    Gao Qingdi; Li Fangzhu; Zhang Jinhua; Pan Yudong; Jiao Yiming

    2005-10-01

    An overview report for the physics design of the HL-2A tokamak is presented. By numerically analyzing the plasma shaping and the vertical instability due to plasma elongation, the requirements for the currents of poloidal magnetic field coils and the control system are put forward. Controlling the plasma profile by using NBI (neutral beam injection) and LHCD (lower hybrid current drive) is investigated, and the high performance modes of operation in HL-2A and modeled and designed. The magnetohydrodynamic instabilities in improved confinement configuration (RS configuration) are studied so as to point out the way of plasma control to perform stationary high performance discharges in HL-2A. In order to offer data for updating the HL-2A divertor, performances of the divertor plasma are simulated. (authors)

  4. On the HL-1M tokamak plasma confinement time

    International Nuclear Information System (INIS)

    Qin Yunwen

    2001-01-01

    Emphasizing that the tokamak plasma confinement time is the plasma particle or thermal energy loss characteristic time, the relevant physical concept and HL-1M tokamak experimental data analyses are reviewed

  5. Vitrified medical wastes bottom ash in cement clinkerization. Microstructural, hydration and leaching characteristics.

    Science.gov (United States)

    Papamarkou, S; Christopoulos, D; Tsakiridis, P E; Bartzas, G; Tsakalakis, K

    2018-04-19

    The present investigation focuses on the utilization of medical wastes incineration bottom ash (MBA), vitrified with soda lime recycled glass (SLRG), as an alternative raw material in cement clinkerization. Bottom ash is recovered from the bottom of the medical wastes incineration chamber, after being cooled down through quenching. It corresponds to 10-15 wt% of the initial medical wastes weight and since it has been classified in the category of hazardous wastes, its safe management has become a major environmental concern worldwide. MBA glasses of various syntheses were initially obtained during the MBA vitrification simultaneously with various amounts of silica scrap (20, 25 and 30 wt% correspondingly). The produced MBA glasses were in turn used for the production of Portland cement clinker, after sintering at 1400 °C, thus substituting traditional raw materials. Both evaluation of vitrification and sintering products was carried out by chemical and mineralogical analyses along with microstructure examination. The final cements were prepared by clinkers co-grinding in a laboratory ball mill with appropriate amounts of gypsum (≈5.0 wt%) and the evaluation of their quality was carried out by determining setting times, standard consistency, expansibility and compressive strength at 2, 7, 28 and 90 days. Finally, the leaching behaviour of the vitrified MBA and hydrated cements, together with the corresponding of the "as received" MBA, was further examined using the standard leaching tests of the Toxicity Characteristic Leaching Procedure (TCLP) and the EN 12457-2. According to the obtained results, the quality of the produced cement clinkers was not affected by the addition of the vitrified MBA in the raw meal, with the trace elements detected in all leachates measured well below the corresponding regulatory limits. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. Rooted in two Countries? Migrant Heritage, emplacement and the ‘Canon van Nederland’.

    NARCIS (Netherlands)

    van Faassen, M.; Hoekstra, F.G.

    2017-01-01

    Rooted in two Countries? Migrant Heritage, emplacement and the ‘Canon van Nederland’. In the cultural heritage sector theorizing emplacement is considered to be vital for identity: “people need to anchor there identity concretely to a location (emplacement)” (Grever&Van Boxtel, 2014). The question

  7. Qualification of a Vitrified High Level Waste Product to Support Used Nuclear Fuel Recycling in the US

    International Nuclear Information System (INIS)

    Murray, P.; Bailly, F.; Strachan, D.; Senentz, G.; Veyer, C.

    2009-01-01

    As part of the Department of Energy (DOE) Global Nuclear Energy Partnership (GNEP), AREVA formed the International Nuclear Recycling Alliance (INRA) consisting of recognized world-leading companies in the area of used nuclear fuel (UNF) recycling,. The INRA team, consisting of AREVA, Mitsubishi Heavy Industries (MHI), Japan Nuclear Fuel Ltd (JNFL), Batelle Memorial Institute (BMI), URS Washington Division and Babcock and Wilcox (B and W), prepared a pre-conceptual design for an upgradable engineering-scale recycling plant with a nominal through put of 800 tHM/y. The pre-conceptual design of this leading-edge facility was based upon the extensive experience of the INRA team in recycling plant design and real world 'lessons learned' from actually building, commissioning, and operating recycling facilities in both France and Japan. The conceptual flowsheet, based upon the COEX TM separations process, separates the useful products for recycling into new fuel and sentences all the remaining fission products and minor actinides (MA) to the high level waste, (HLW) for vitrification. The proposed vitrified waste product will be similar to that currently produced in recycling plants in France. This wasteform has been qualified in France by conducting extensive studies and demonstrations. In the US, the qualification of vitrified glass products has been conducted by the US National Laboratories for the Defence Waste Processing Facility (DWPF), the West Valley Demonstration Plant (WVDP), and the Waste Treatment Plant (WTP). The vitrified waste product produced by recycling is sufficiently different from these current waste forms to warrant additional trials and studies. In this paper we review the differences in the vitrified waste forms previously qualified in the US with that produced from recycling of UNF in France. The lessons learned from qualifying a vitrified waste form in Europe is compared to the current US process for vitrified waste qualification including waste

  8. Operational considerations in drift emplacement of waste packages

    International Nuclear Information System (INIS)

    Benton, H.A.

    1993-01-01

    This paper discusses the operational considerations as well as the advantages and disadvantages of emplacing waste packages in drifts in a repository. The considerations apply particularly to the potential repository for spent nuclear fuel and high-level waste glass at Yucca Mountain, although most of the considerations and the advantages and disadvantages discussed in this paper do not necessarily represent the official views of the DOE or of the Management and Operations Contractor, since most of these considerations are still under active discussion and the final decisions will not be made for some time - perhaps years. This paper describes the issues, suggests some principles upon which decisions should be based, and states some of the most significant advantages and disadvantages of the emplacement modes, and the associated waste package types and thermal loadings

  9. Sediment mechanical response due to emplacement of a waste canister

    International Nuclear Information System (INIS)

    Karnes, C.H.; Dawson, P.R.; Silva, A.J.; Brown, W.T.

    1980-01-01

    Preliminary studies have been conducted to determine the interaction between a waste canister and seabed sediment during and after emplacement. Empirical and approximate methods for determining the depth reached by a freefall penetrator indicate that a boosted penetrator emplacement method may be necessary. Hole closure is necessary, but has not been verified because calculations and laboratory experiments show sensitivity to boundary conditions which control the degree of dynamic hole closure. Laboratory studies show that closure will take place by creep deformation but closure times in seabed environments are uncertain. For assumed thermomechanical properties of sediments, it is shown that a heat generating waste canister will probably not move a significant distancce during the heat generation period

  10. State-of-the-art review of quality assurance techniques for vitrified high level waste

    International Nuclear Information System (INIS)

    Miller, P.L.H.

    1984-07-01

    Quality assurance is required for certain chemical and physical properties of both the molten glass pour and the solidified glass within the stainless steel container. It is also required to monitor the physical condition of the container lid weld. A review is presented of techniques which are used or which might be adapted for use in the quality assurance of vitrified high level waste. For the most part only non-intrusive methods have been considered, however, some techniques which are not strictly non-intrusive have been reviewed where a non-intrusive technique has not been identified or where there are other advantages associated with the particular technique. In order to identify suitable candidate techniques reference has been made to an extensive literature survey and experts in the fields of nuclear waste technology, glass technology, non-destructive testing, chemical analysis and remote analysis have been contacted. The opinions of manufacturers and users of specific techniques have also been sought. A summary is also given of those techniques which can most readily be applied to the problem of quality assurance for vitrified waste as well as recommendations for further research into techniques which might be adapted to suit this application. (author)

  11. In vitro production of buffalo embryos from stepwise vitrified immature oocytes.

    Science.gov (United States)

    Abd-Allah, Saber Mohammed

    2009-01-01

    This study was conducted to produce buffalo embryos in vitro from stepwise vitrified immature oocytes. Cumulus oocyte complexes (COCs) were obtained from the ovaries of slaughtered buffalo and were collected from the local abattoir. Selected COCs were exposed to a vitrification solution consisting of 40% ethylene glycol (EG) plus 0.3 M trehalose and 20% polyvinyl pyrrolidone (PVP) for 1 min and loaded in 0.25 ml plastic mini-straws containing 100 microl of 10% sucrose. The loaded cryostraws were cryopreserved by stepwise vitrification and were stored in liquid nitrogen for 4 to 6 months. Data analysis revealed a high percentage of post-thawing morphologically normal immature oocytes (80.7%) with a low percentage of damaged oocytes. There were no significant differences in the maturation (82.1%), cleavage (47.6%) and buffalo embryo development (15.4%) produced by the stepwise vitrified immature oocytes in comparison to the three observations in fresh oocytes (88.3%, 50.4% and 19.4%, respectively, p<0.05).

  12. Alteration of medieval stained-glasses. Contribution to the long-term behaviour of vitrified wastes

    International Nuclear Information System (INIS)

    Sterpenich, J.

    1998-01-01

    In this work, the behaviour of glasses during alteration have been studied in two different ways: 1)study of the alteration of medieval stained-glasses 2)experimental leaching of modelled glasses. Medieval stained-glasses have a silico-calcic and alkaline composition. It appears three different alteration modes for these glasses: 1)by condensation waters 2)by atmospheric agents 3)by porosity waters and humic acids. A chemical study of the altered areas has allowed to understand the alteration behaviour of a lot of elements: in particular transition elements, heavy metals and some rare earths. On the other hand, two vitrified wastes and a glass having the same composition of the potassic medieval stained-glasses have been leached in a static mode (pH=1 to 10, T=20 to 80 degrees Celsius, T=12 hours to 6 months). These experiments have revealed that the alteration mechanisms depend on the pH of the solution and on the chemical composition of the glass. An increasing durability of glasses in terms of the global polymerization degree has been revealed too. At last, the behaviours of glasses during alteration, observed with natural and experimental conditions, show that it is necessary to study natural analogous for predicting the long-term behaviour of vitrified wastes. (O.M.)

  13. Underground disposal of vitrified high level radioactive waste: a review of research and development

    International Nuclear Information System (INIS)

    1982-11-01

    A review has been undertaken of the worldwide status of research and development related to the geological disposal of vitrified high level radioactive waste. The nature and quantities of vitrified high level waste that will arise from nuclear power generation in the UK have been estimated and considered. The safety case for establishing a geological repository would have to be based on predictive models, which could adequately represent the interactions and effects of a wide range of gradual processes and possible sudden events. No detailed repository design has yet been published, but the configuration currently favoured, in the UK and in most other countries, comprises a small number of vertical shafts, from which a network of horizontal tunnels would be excavated. Waste packages would be placed in holes drilled in the floors of the tunnels. The excavation of such a repository in hard crystalline rock, in a thick homogeneous formation of rock salt, or in the less plastic argillaceous formations, appears to be within the scope of present technology. Rock types available in the UK, which are likely to prove suitable for the accommodation of a repository, have been identified. The strategies and programmes for high level waste disposal in other countries have been reviewed. (U.K.)

  14. Leaching of vitrified high-level-active-waste in a near reality simulated repository system

    International Nuclear Information System (INIS)

    Froeschen, W.; Wolf, G.K.

    1987-01-01

    In the FRG it is planned to vitrify the high level waste from spent fuel reprocessing and to dispose of in a salt-mine. If water penetrates into the repository a highly corrosive brine (Q-brine) will be formed and radioactive material may be leached from the glasses and transported to human environment. The corrosion system of brine, corroded steel containers of the vitrified waste, and waste-glasses was investigated under near reality conditions. Experiments in hydrothermal environment were carried out including gamma radiation of the waste-glasses and ceramic In Can Lining between glasses and metallic containments. Screening experiments by application of external cobalt-gamma-radiation showed no principal changes in leaching behaviour of simulate glasses compared to leaching without radiation. Radiation effects result in pH changes mainly which are diminished by buffer capacity of Q-brine. Lining of steel containments with ceramic fleece does not reduce leaching but retards solution of Mo and Sr into brine. Decreasing of elements Sr, Cs and Mo in the near surface area of the glass and increasing of Zr and Ti has been found to be enhanced considerably in presence of canister corrosion products in Q-brine as well as in NaCl-leaching solution. (orig.) With 13 refs., 22 figs [de

  15. In vitro production of buffalo embryos from stepwise vitrified immature oocytes

    Directory of Open Access Journals (Sweden)

    Saber Mohammed Abd-Allah

    2009-09-01

    Full Text Available This study was conducted to produce buffalo embryos in vitro from stepwise vitrified immature oocytes. Cumulus oocyte complexes (COCs were obtained from the ovaries of slaughtered buffalo and were collected from the local abattoir. Selected COCs were exposed to a vitrification solution consisting of 40% ethylene glycol (EG plus 0.3 M trehalose and 20% polyvinyl pyrrolidone (PVP for 1 min and loaded in 0.25 ml plastic mini-straws containing 100 µl of 10% sucrose. The loaded cryostraws were cryopreserved by stepwise vitrification and were stored in liquid nitrogen for 4 to 6 months. Data analysis revealed a high percentage of post-thawing morphologically normal immature oocytes (80.7% with a low percentage of damaged oocytes. There were no significant differences in the maturation (82.1%, cleavage (47.6% and buffalo embryo development (15.4% produced by the stepwise vitrified immature oocytes in comparison to the three observations in fresh oocytes (88.3%, 50.4% and 19.4%, respectively, p<0.05.

  16. Effect of Nanoparticles on the Survival and Development of Vitrified Porcine GV Oocytes.

    Science.gov (United States)

    Li, W J; Zhou, X L; Liu, B L; Dai, J J; Song, P; Teng, Y

    BACKGROUND: Some mammalian oocytes have been successfully cryopreserved by vitrification. However, the survival and developmental rate of vitrified oocytes is still low. The incorporation of nanoparticles into cryoprotectant (CPA) may improve the efficiency of vitrification by changing the properties of solutions. The toxicity of different concentrations of hydroxy apatite (HA), silica dioxide (SO 2 ), aluminum oxide (Al 2 O 3 ) and titanium dioxide (TiO 2 ) nanoparticles (20 nm in diameter) to oocytes was tested and the toxicity threshold value of each nanoparticle was determined. Porcine GV oocytes were vitrified in optimized nano-CPA, and effects of diameter and concentration of nanoparticles on the survival rate and developmental rate of porcine GV oocytes were compared. HA nanoparticles have demonstrated the least toxicity among four nanoparticles and the developmental rate of GV-stage porcine oocytes was 100% when its concentration was lower than 0.5%. By adding 0.1% HA into VS, the developmental rate of GV-stage porcine oocytes (22%) was significantly higher than other groups. The effect of vitrification in nano-CPA on oocytes was related to the concentration of HA nanoparticles rather than their size. By adding 0.05% HA nanoparticles (60nm in diameter), the developmental rate increased dramatically from 14.7% to 30.4%. Nano-cryopreservation offers a new way to improve the effect of survival and development of oocytes, but the limitation of this technology shall not be ignored.

  17. Wireless Sensor Networks for Detection of IED Emplacement

    Science.gov (United States)

    2009-06-01

    unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Abstract We are investigating the use of wireless nonimaging -sensor...networks for the difficult problem of detection of suspicious behavior related to IED emplacement. Hardware for surveillance by nonimaging -sensor networks...with people crossing a live sensor network. We conclude that nonimaging -sensor networks can detect a variety of suspicious behavior, but

  18. Piglets produced by transfer of vitrified porcine embryos after stepwise dilution of cryoprotectants.

    Science.gov (United States)

    Kobayashi, S; Takei, M; Kano, M; Tomita, M; Leibo, S P

    1998-02-01

    A total of 498 porcine embryos at various stages of development collected from superovulated gilts was used to investigate cryopreservation. First, blastocysts (BL), expanded blastocysts (ExB), and hatched blastocysts (HB) were used to determine the effect of exposure to concentrated solutions of ethylene glycol as cryoprotective additives (CPAs) on embryo survival. Then, survival of other embryos after vitrification by rapid cooling was determined. Based on their development after 48 h in culture, embryos were not injured by being exposed to 2.0 M ethylene glycol (EG) for 15 min or to 2.0 M EG for 5 min and then to a solution of 8.0 M EG in 7% polyvinylpyrrolidone (PVP) for 1 min. The CPAs were removed from the embryos by diluting them with 1.7 M galactose. To vitrify the embryos, they were exposed to 2.0 M EG for 5 min and then were pipetted directly into short columns of 8.0 M EG-PVP contained within (1.25-ml plastic straws and separated from long columns of 1.7 M galactose by an air bubble. The straws were plunged directly into LN2. After the straws were warmed rapidly in a 25 degrees C water bath, the embryos were immediately mixed with galactose within the straws by shaking them vigorously to mix the contents. In sequential experiments, three methods were used to dilute the CPA solutions. Method 1: Embryos in the EG-PVP-galactose mixture were expelled from the straws and rinsed and cultured in modified CZB medium (mCZB). Method II: Embryos in the mixture were placed briefly into 1.5 M EG and then rinsed and cultured in mCZB. Method III: Embryos in the mixture were rinsed in 1.0 M EG and then in 0.5 M EG and finally rinsed with mCZB and cultured. After 48 h in culture, the respective percentages of survival of embryos vitrified as BL, ExB, or HB were: Method I, 21, 32, and 13%; Method II, 9, 40, and 24%; Method III, 35, 85, and 71%. Of 20 additional ExB vitrified embryos diluted by Method III and transferred into a recipient, four developed into live piglets

  19. Fast crab cavity failures in HL-LHC

    CERN Document Server

    Yee-Rendon, B; Calaga, R; Tomas, R; Zimmermann, F; Barranco, J

    2014-01-01

    Crab cavities (CCs) are a key ingredient of the High-Luminosity Large Hadron Collider (HL-LHC) to ensure head on collisions at the main experiments (ATLAS and CMS) and fully profit from the smaller provided by the ATS optics [1]. At KEKB, CCs have exhibited abrupt changes of phase and voltage during a time period of few LHC turns and considering the large energy stored in the HL-LHC beam, CC failures represent a serious risk to the LHC machine protection. In this paper, we discuss the effect of CC voltage or phase changes on a time interval similar to, or longer than, the one needed to dump the beam. The simulations assume a realistic steady-state distribution to assess the beam losses for the HL-LHC. Additionally, some strategies are studied in order to reduce the damage caused by the CC failures.

  20. Physics Prospects at the HL-LHC with ATLAS

    CERN Document Server

    Duncan, Anna Kathryn; The ATLAS collaboration

    2017-01-01

    The High-Luminosity LHC aims to provide a total integrated luminosity of 3000 fb-1 from p-p collisions at $\\sqrt{s}$ = 14 TeV over the course of $\\sim$ 10 years, reaching instantaneous luminosities of up to L = 7.5 $\\times$ 1034cm$^{-2}$s$^{-1}$, corresponding to an average ($\\mu$) of 200 inelastic p-p collisions per bunch crossing. The upgraded ATLAS detector must be able to cope well with increased occupancies and data rates. The performance of the upgrade has been estimated in full simulation studies, assuming expected HL-LHC conditions and a detector configuration intended to maximise physics performance and discovery potential at the HL-LHC. The performance is expected to be similar to what we have now. Simulation studies have been carried out to evaluate the prospects of various benchmark physics analyses to be performed using the upgraded ATLAS detector with the full HL-LHC dataset.

  1. Acridones as inducers of HL-60 cell differentiation.

    Science.gov (United States)

    Kawaii, S; Tomono, Y; Katase, E; Ogawa, K; Yano, M; Takemura, Y; Ju-ichi, M; Ito, C; Furukawa, H

    1999-03-01

    Fifteen acridone alkaloids were examined for their activity of induction of human promyelocytic leukemia cell (HL-60) differentiation. HL-60 cells were differentiated into mature monocyte/macrophage by atalaphyllidine (9), atalaphyllinine (12), and des-N-methylnoracronycine (13). The activities of NBT reduction, nonspecific esterase, and phagocytosis, were induced by 2.5 microM of 9, 12, and 13. After a 4-day treatment, 9, 12, and 13 at 10 microM inhibited clonal proliferation of HL-60 cells by 28, 96, and 63%, respectively. The structure-activity relationship established from the results revealed that hydroxyl group at C-1 and prenyl group at C-2 had an important role.

  2. Modification of steel 35 HL surge current during crystallization

    Directory of Open Access Journals (Sweden)

    Zhbanova O.M.

    2017-04-01

    Full Text Available The method of electro steel melt modification 35 HL variable polarity current pulses with a duration of more 10-3s frequency within the 5–33 Hz, 5–24 porosity meanders, strength 30–40 A at a voltage of 180–240 V during crystallization, which allows to obtain high-quality castings 35 HL steel grade. Show that electro melt processing improves the structure and reduces the physical heterogeneity of castings and increases the rate of dissolution of metallic impurities and other components in the melt, providing fine-grained structure and increases the homogeneity of metal carbides reduces the amount of manganese reduces gases and nonmetallic inclusions. Modifying steel 35 HL pulse current during crystallization of the melt increases the physical and mechanical properties of tempered steel, increasing yield strength by 30 %, the tensile strength at 7 % elongation of 1,5 % relative narrowing by 2 %, toughness at 20 %.

  3. Study on improvement in reliability of inventory assessment in vitrified waste for long-term safety of geological disposal

    International Nuclear Information System (INIS)

    Ishikawa, Masumi; Kaneko, Satoru; Kitayama, Kazumi; Ishiguro, Katsuhiko; Ueda, Hiroyoshi; Wakasugi, Keiichiro; Shinohara, Nobuo; Okumura, Keisuke; Chino, Masamichi; Moriya, Noriyasu

    2009-01-01

    Since quality control issues for vitrified waste are defined mainly with the focus on the transport and interim storage of the waste rather than the long-term safety of geological disposal, they do not cover inventories of long-lived nuclides that are of most interest in the safety assessment of geological disposal. Therefore, we suggest a flow chart for the assessment of inventories of long-lived nuclides in the vitrified waste focusing on the measured values. This includes an indirect assessment with indicative nuclides that have been already measured in the returned vitrified wastes from abroad. In order to apply this flow chart for commercial operation, its applicability should be examined for cases with a variation in burn-up history and with an uncertainty associated with carry-over fraction at reprocessing. We started an R and D program to examine the applicability as well as to improve the reliability of the nuclide generation/decay code and the nuclear data library using liquid waste from spent fuel with a clear irradiation history. To solve the issue of quality control for vitrified waste, a comprehensive study is needed in aspects not only of geological disposal field but also of operation of a nuclear power plant, reprocessing of spent fuel and vitrification of liquid waste. This study is a pioneering study conducted to integrate them. (author)

  4. Study on fast ion loss in HL-2A tokamak

    International Nuclear Information System (INIS)

    Liu Yi; Sun Tengfei; Ji Xiaoquan

    2012-01-01

    Experiments with a high-energy deuterium neutral beam (NB) injection (30 keV, about 0.6 MW) were performed on the HL-2A tokamak. Analysis of neutron decay following the NB 'blip' injection indicates that tangentially injected beam ions are well confined, slowing down classically in the HL-2A. Anomalous losses of beam ions were observed when a beta-induced Alfven acoustic (BAAE) mode was present in the plasma. Such a high energetic particle driven mode led to fast-ion loss, showing a strong influence of the energetic particle driven mode on the fast-ion transport. (authors)

  5. Statistical process control: An approach to quality assurance in the production of vitrified nuclear waste

    International Nuclear Information System (INIS)

    Pulsipher, B.A.; Kuhn, W.L.

    1987-01-01

    Current planning for liquid high-level nuclear wastes existing in the United States includes processing in a liquid-fed ceramic melter to incorporate it into a high-quality glass, and placement in a deep geologic repository. The nuclear waste vitrification process requires assurance of a quality product with little or no final inspection. Statistical process control (SPC) is a quantitative approach to one quality assurance aspect of vitrified nuclear waste. This method for monitoring and controlling a process in the presence of uncertainties provides a statistical basis for decisions concerning product quality improvement. Statistical process control is shown to be a feasible and beneficial tool to help the waste glass producers demonstrate that the vitrification process can be controlled sufficiently to produce an acceptable product. This quantitative aspect of quality assurance could be an effective means of establishing confidence in the claims to a quality product

  6. Statistical process control: An approach to quality assurance in the production of vitrified nuclear waste

    International Nuclear Information System (INIS)

    Pulsipher, B.A.; Kuhn, W.L.

    1987-02-01

    Current planning for liquid high-level nuclear wastes existing in the US includes processing in a liquid-fed ceramic melter to incorporate it into a high-quality glass, and placement in a deep geologic repository. The nuclear waste vitrification process requires assurance of a quality product with little or no final inspection. Statistical process control (SPC) is a quantitative approach to one quality assurance aspect of vitrified nuclear waste. This method for monitoring and controlling a process in the presence of uncertainties provides a statistical basis for decisions concerning product quality improvement. Statistical process control is shown to be a feasible and beneficial tool to help the waste glass producers demonstrate that the vitrification process can be controlled sufficiently to produce an acceptable product. This quantitative aspect of quality assurance could be an effective means of establishing confidence in the claims to a quality product. 2 refs., 4 figs

  7. Long time storage containers for spent fuels and vitrified wastes: synthesis of the studies

    International Nuclear Information System (INIS)

    Beziat, A.

    2004-01-01

    This report presents a synthesis of the studies relatives to the containers devoted to the long time spent fuels storage and vitrified wastes packages. These studies were realized in the framework of the axis 3 of the law of 1991 on the radioactive wastes management. The first part is devoted to the presentation of the studies. The container sizing studies which constitute the first containment barrier are then presented. The material choice and the closed system are also detailed. The studies were validate by the realization of containers models and an associated demonstration program is proposed. A synthesis of the technical and economical studies allowed to determine the components and operation costs. (A.L.B.)

  8. Numerical modeling of heat outflux from a vitrified high level waste

    International Nuclear Information System (INIS)

    Aravind, Arun; Jayaraj, Aparna; Seshadri, H.; Balasubramaniyan, V.

    2018-01-01

    Heat generating vitrified high-level waste is initially stored in interim storage facility with adequate cooling for sufficient period of time, and then proposed to be disposed of in deep geological repositories. Heat flux from the waste form can cause thermo mechanical changes within the disposal module and also in the surrounding rock. It may change the permeability of rock fractures over a period of time. It is very essential to study the long term performance of deep geological repository to build confidence in the design and over all operation of the disposal facility. In this study a numerical model was developed to study the temperature distribution in the waste matrix and also the heat out flux to the surrounding rock matrix

  9. Factors Analysis of Spontaneous Abortion after Thawed-vitrified Blastocysts Transfer

    Institute of Scientific and Technical Information of China (English)

    Dong YANG; Zheng-yi SUN; Cheng-yan DENG; Qi YU; Fang-fang HE

    2008-01-01

    Objective To investigate the factors resulting in spontaneous abortion after transferring frozen-thawing blastocysts. Methods A total of 108 cases transferring vitrified blastocysts were divided into two groups: abortion group (n =20) and ongoing group (n=88). Cytogenetic analysis of apoblemas was performed in 12 cases of the abortion.Results The overall spontaneous abortion rate was 18.50%(20/108) and the early spontaneous rate was 16.67%(18/108). ,4 significant difference in maternal age was observed (abortion group: 33.3±4.0 years, ongoing group: 31.0±3.6 years, P=0.02). No difference in other parameters was found. Cytogenetic analysis of apoblemas was obtained for 12 cases, and 2 specimens were contaminated. Seven of ten patients had abnormal karyotypes. Conclusion The underlying cause of spontaneous abortion after transferring frozen thawing blastocysts appears to be abnormal karyotypes.Advancing maternal age seems to increase the risk of spontaneous abortion.

  10. Intermediate storage facility for vitrified high level waste from the reprocessing of spent nuclear fuel

    International Nuclear Information System (INIS)

    1978-04-01

    An intermediate storage facility for vitrified high level waste is described. The design was made specifically for Swedish conditions but can due to modular design be applied also for other conditions. Most of the plant is located underground with a rock cover of about 30 m in order to provide protection against external forces such as acts of war and sabotage. The storage area consists of four caverns each with 150 pits. Each pit can take 10 waste cylinders of 0.4 m diameter and 1.5 m length containing 150 liters of glass. The capacity can be increased by adding additional caverns. Cooling is obtained by forced air convection. Reception areas, auxiliary systems and operation of the plant are also described

  11. Will vitrified high active reactor waste be deposited on the seabed

    International Nuclear Information System (INIS)

    Koksvik, R.M.

    1978-01-01

    The NRPB in the UK has carried out a preliminary study on the consequences of the disposal of high active waste on the ocean bed at great depths. This is reported in 'Assessment of the radiological protection aspects of disposal of high level waste on the ocean floor', by P.D. Grimswood and G.A.M. Webb (NRPB-R 48). This report is here briefly summarised and commented on. It deals with the radiological consequences to man of the erosion and corrosion of glassified (vitrified) radioactive waste, in the deep (>4000m) ocean, radionuclide migration and path ways to man. The conclusion is that considerations of radiological protection do not preclude the disposal of specially treated radioactive waste on the ocean bed. (JIW)

  12. Performance assessment of the disposal of vitrified high-level waste in a clay layer

    International Nuclear Information System (INIS)

    Mallants, Dirk; Marivoet, Jan; Sillen, Xavier

    2001-01-01

    Deep disposal is considered a safe solution to the management of high-level radioactive waste. The safety is usually demonstrated by means of a performance assessment. This paper discusses the methodological aspects and some of the results obtained for the performance assessment of the disposal of vitrified high-level waste in a clay layer in Belgium. The calculations consider radionuclide migration through the following multi-barrier components, all of which contribute to the overall safety: (1) engineered barriers and the host clay layer, (2) overlying aquifer, and (3) biosphere. The interfaces between aquifers and biosphere are limited to the well and river pathway. Results of the performance assessment calculations are given in terms of the time evolution of the dose rates of the most important fission and activation products and actinides. The role of the glass matrix in the overall performance of the repository is also discussed

  13. Evaluation of non-destructive methods for quality checking of vitrified high level waste

    International Nuclear Information System (INIS)

    Huddleston, J.; Hutchinson, I.G.; Metcalfe, B; Mossop, J.R.; Taylor, B.L.; Wilkins, C.G.

    1990-03-01

    Tomography and X-ray absorptiometry have been performed on a container of vitrified high level waste produced by the FINGAL process in 1966. The glass weighed 40-50 kg and when produced contained 10 14 Bq of β/γ activity. The studies have been carried out without recourse to specialised high activity handling facilities. Measurements were carried out by lowering the glass from a shielded container, through a measurement collar, into one of the original storage holes in the floor of the FINGAL plant. The tomographs showed clearly various artefacts in the glass but no cracks or voids were observed within the resolution of the method (0.5-1 mm). The X-ray absorptiometric measurements were made using a 160 kV tube. They showed the presence of about 7% uranium (determined from the magnitude of its K-absorption edge). The resulting strong absorption of X-rays limited the measurements that could be made. (author)

  14. Efficient production of live offspring from mouse oocytes vitrified with a novel cryoprotective agent, carboxylated ε-poly-L-lysine.

    Directory of Open Access Journals (Sweden)

    Hitomi Watanabe

    Full Text Available In cryopreservation of mammalian germ cells, unfertilized oocytes are one of the most available stages because these cryopreserved oocytes can be used for assisted reproductive technologies, including in vitro fertilization (IVF and intracytoplasmic sperm injection. However, it has been generally reported that the fertility and developmental ability of the oocytes are reduced by cryopreservation. Therefore further improvement will be required. Very recently, a new cryoprotective agent (CPA, called as carboxylated ε-poly-L-lysine (COOH-PLL, has been developed to reduce physical and physiological damage by cryopreservation in mammalian stem cells. However, it is unclear the effect of COOH-PLL on fertility and developmental ability of vitrified oocytes. In this study, we used COOH-PLL as a CPA with ethylene glycol (EG for vitrification of mouse oocytes. Cumulus-oocyte complexes (COCs were collected from ICR mice and then vitrified with Cryotop using different concentration of COOH-PLL and EG. A combined treatment with COOH-PLL and EG showed high survival rate (more than 90% of vitrified-warmed COCs after in vitro fertilization. In addition, the fertility and developmental ability of COCs vitrified with E20P10 [EG 20% (v/v and COOH-PLL 10% (w/v] or E15P15 group (EG 15% and COOH-PLL 15% were significantly higher than those with E10P20 (EG10% and COOH-PLL 20% or P30 group (PLL30%. The vitrified COCs in E20P10 group developed to term at a high success rate (46.2% and it was significantly higher than that in control (E30 group (34.8%. Our present study demonstrated for the first time that COOH-PLL is effective for vitrification of mouse oocytes.

  15. Clinical outcome of fresh and vitrified-warmed blastocyst and cleavage-stage embryo transfers in ethnic Chinese ART patients

    Directory of Open Access Journals (Sweden)

    Tong Guo

    2012-10-01

    Full Text Available Abstract Objectives This study sought to evaluate the outcome of fresh and vitrified-warmed cleavage-stage and blastocyst-stage embryo transfers in patients undergoing ART treatment within an ethnic Chinese population. Study design We compared the clinical results of embryo transfer on the 3rd (cleavage stage or 5th (blastocyst stage day after oocyte retrieval, including clinical pregnancy rates, implantation rates and multiple pregnancy rates. Results Our data showed that blastocyst transfer on day 5 did not significantly increase clinical pregnancy rate (41.07% vs 47.08%, p>0.05 and implantation rate (31.8% vs 31.2%, p>0.05 in patients under 35 years of age, in comparison with day 3 cleavage stage embryo transfer. In patients older than 35 years of age, the clinical pregnancy rate after blastocyst transfer was slightly decreased compared with cleavage stage embryo transfer (33.33% vs 42.31%, p>0.05. Unexpectedly, It was found that vitrified-warmed blastocyst transfer resulted in significantly higher clinical pregnancy rate (56.8% and implantation rate (47% compared with fresh blastocyst transfer in controlled stimulation cycles (41.07% and 31.8%, respectively. For patients under 35 years of age, the cumulative clinical pregnancy rate combining fresh and vitrified-warmed blastocyst transfer cycles were significantly higher compared to just cleavage-stage embryo transfer (70.1% versus 51.8%, p Conclusions In an ethnic Chinese patient population, fresh blastocyst transfer does not significantly increase clinical pregnancy rate. However, subsequent vitrified-warmed blastocyst transfer in a non-controlled ovarian hyperstimulation cycle dramatically improves clinical outcomes. Therefore, blastocyst culture in tandem with vitrified-warmed blastocyst transfer is recommended as a favourable and promising protocol in human ART treatment, particularly for ethnic Chinese patients.

  16. Clinical outcome of fresh and vitrified-warmed blastocyst and cleavage-stage embryo transfers in ethnic Chinese ART patients.

    Science.gov (United States)

    Tong, Guo Qing; Cao, Shan Ren; Wu, Xun; Zhang, Jun Qiang; Cui, Ji; Heng, Boon Chin; Ling, Xiu Feng

    2012-10-05

    This study sought to evaluate the outcome of fresh and vitrified-warmed cleavage-stage and blastocyst-stage embryo transfers in patients undergoing ART treatment within an ethnic Chinese population. We compared the clinical results of embryo transfer on the 3rd (cleavage stage) or 5th (blastocyst stage) day after oocyte retrieval, including clinical pregnancy rates, implantation rates and multiple pregnancy rates. Our data showed that blastocyst transfer on day 5 did not significantly increase clinical pregnancy rate (41.07% vs 47.08%, p>0.05) and implantation rate (31.8% vs 31.2%, p>0.05) in patients under 35 years of age, in comparison with day 3 cleavage stage embryo transfer. In patients older than 35 years of age, the clinical pregnancy rate after blastocyst transfer was slightly decreased compared with cleavage stage embryo transfer (33.33% vs 42.31%, p>0.05). Unexpectedly, It was found that vitrified-warmed blastocyst transfer resulted in significantly higher clinical pregnancy rate (56.8%) and implantation rate (47%) compared with fresh blastocyst transfer in controlled stimulation cycles (41.07% and 31.8%, respectively). For patients under 35 years of age, the cumulative clinical pregnancy rate combining fresh and vitrified-warmed blastocyst transfer cycles were significantly higher compared to just cleavage-stage embryo transfer (70.1% versus 51.8%, p<0.05). However, the cumulative multiple pregnancy rates showed no significant difference between the two groups. In an ethnic Chinese patient population, fresh blastocyst transfer does not significantly increase clinical pregnancy rate. However, subsequent vitrified-warmed blastocyst transfer in a non-controlled ovarian hyperstimulation cycle dramatically improves clinical outcomes. Therefore, blastocyst culture in tandem with vitrified-warmed blastocyst transfer is recommended as a favourable and promising protocol in human ART treatment, particularly for ethnic Chinese patients.

  17. Thermally-assisted Magma Emplacement Explains Restless Calderas

    Science.gov (United States)

    Amoruso, A.; Crescentini, L.; D'Antonio, M.; Acocella, V.

    2017-12-01

    Many calderas show repeated unrest over centuries. Though probably induced by magma, this unique behaviour is not understood and its dynamics remains elusive. To better understand these restless calderas, we interpret deformation data and build thermal models of Campi Flegrei, Italy, which is the best-known, yet most dangerous calderas, lying to the west of Naples and restless since the 1950s at least.Our elaboration of the geodetic data indicates that the inflation and deflation of magmatic sources at the same location explain most deformation, at least since the build-up of the last 1538 AD eruption. However, such a repeated magma emplacement requires a persistently hot crust.Our thermal models show that the repeated emplacement was assisted by the thermal anomaly created by magma that was intruded at shallow depth 3 ka before the last eruption and, in turn, contributed to maintain the thermal anomaly itself. This may explain the persistence of the magmatic sources promoting the restless behaviour of the Campi Flegrei caldera; moreover, it explains the crystallization, re-melting and mixing among compositionally distinct magmas recorded in young volcanic rocks.Available information at other calderas highlights similarities to Campi Flegrei, in the pattern and cause of unrest. All monitored restless calderas have either geodetically (Yellowstone, Aira Iwo-Jima, Askja, Fernandina and, partly, Long Valley) or geophysically (Rabaul, Okmok) detected sill-like intrusions inducing repeated unrest. Some calderas (Yellowstone, Long Valley) also show stable deformation pattern, where inflation insists on and mimics the resurgence uplift. The common existence of sill-like sources, also responsible for stable deformation patterns, in restless calderas suggests close similarities to Campi Flegrei. This suggests a wider applicability of our model of thermally-assisted sill emplacement, to be tested by future studies to better understand not only the dynamics of restless

  18. Near-surface storage facilities for vitrified high-level wastes

    International Nuclear Information System (INIS)

    Kondrat'ev, A.N.; Kulichenko, V.V.; Kryukov, I.I.; Krylova, N.V.; Paramoshkin, V.I.; Strakhov, M.V.

    1980-01-01

    Concurrently with the development of methods for solidifying liquid radioactive wastes, reliable and safe methods for the storage and disposal of solidified wastes are being devised in the USSR and other countries. One of the main factors affecting the choice of storage conditions for solidified wastes originating from the vitrification of high-level liquid wastes from fuel reprocessing plants is the problem of removing the heat produced by radioactive decay. In order to prevent the temperature of solidified wastes from exceeding the maximum permissible level for the material concerned, it is necessary to limit either the capacity of waste containers or the specific heat release of the wastes themselves. In order that disposal of high-level wastes in geological formations should be reliable and economic, solidified wastes undergo interim storage in near-surface storage facilities with engineered cooling systems. The paper demonstrates the relative influences of specific heat release, of the maximum permissible storage temperature for vitrified wastes and of the methods chosen for cooling wastes in order for the dimensions of waste containers to be reduced to the extent required. The effect of concentrating wastes to a given level in the vitrification process on the cost of storage in different types of storage facility is also examined. Calculations were performed for the amount of vitrified wastes produced by a reprocessing plant with a capacity of five tonnes of uranium per 24 hours. Fuel elements from reactors of the water-cooled, water-moderated type are sent for reprocessing after having been held for about two years. The dimensions of the storage facility are calculated on the assumption that it will take five years to fill

  19. Analogue experiments as benchmarks for models of lava flow emplacement

    Science.gov (United States)

    Garel, F.; Kaminski, E. C.; Tait, S.; Limare, A.

    2013-12-01

    During an effusive volcanic eruption, the crisis management is mainly based on the prediction of lava flow advance and its velocity. The spreading of a lava flow, seen as a gravity current, depends on its "effective rheology" and on the effusion rate. Fast-computing models have arisen in the past decade in order to predict in near real time lava flow path and rate of advance. This type of model, crucial to mitigate volcanic hazards and organize potential evacuation, has been mainly compared a posteriori to real cases of emplaced lava flows. The input parameters of such simulations applied to natural eruptions, especially effusion rate and topography, are often not known precisely, and are difficult to evaluate after the eruption. It is therefore not straightforward to identify the causes of discrepancies between model outputs and observed lava emplacement, whereas the comparison of models with controlled laboratory experiments appears easier. The challenge for numerical simulations of lava flow emplacement is to model the simultaneous advance and thermal structure of viscous lava flows. To provide original constraints later to be used in benchmark numerical simulations, we have performed lab-scale experiments investigating the cooling of isoviscous gravity currents. The simplest experimental set-up is as follows: silicone oil, whose viscosity, around 5 Pa.s, varies less than a factor of 2 in the temperature range studied, is injected from a point source onto a horizontal plate and spreads axisymmetrically. The oil is injected hot, and progressively cools down to ambient temperature away from the source. Once the flow is developed, it presents a stationary radial thermal structure whose characteristics depend on the input flow rate. In addition to the experimental observations, we have developed in Garel et al., JGR, 2012 a theoretical model confirming the relationship between supply rate, flow advance and stationary surface thermal structure. We also provide

  20. Comparison of the developmental potential of 2-week-old preantral follicles derived from vitrified ovarian tissue slices, vitrified whole ovaries and vitrified/transplanted newborn mouse ovaries using the metal surface method

    Directory of Open Access Journals (Sweden)

    Hsu Kung-Hao

    2008-04-01

    comparing 14-day old ovarian tissue (ovarian tissue slices and whole ovaries and whole newborn ovaries vitrified in 6 μl droplet, lower success rates of antral-like cavity formation and COCs collection were found in the whole ovaries group. Conclusion Our results suggest that the metal plate surface vitrification method is an appropriate and convenient method for cryopreservation of mouse ovaries and preantral follicles. The droplet volume of vitrification solution in 2 μl and 6 μl can be an option.

  1. HL-1 tokamak data acquisition system and its initial application in the physical experiment

    International Nuclear Information System (INIS)

    Deng Huichen; Fu Bo; Dong Jiafu

    1989-11-01

    A HL-1 tokamak data acquisition system has been developed and has been used in the physical experiment. The hardware and software configuration of the system, as well as the typical acquired data in the HL-1 experiment are introduced

  2. Thermally-assisted Magma Emplacement Explains Restless Calderas.

    Science.gov (United States)

    Amoruso, Antonella; Crescentini, Luca; D'Antonio, Massimo; Acocella, Valerio

    2017-08-11

    Many calderas show repeated unrest over centuries. Though probably induced by magma, this unique behaviour is not understood and its dynamics remains elusive. To better understand these restless calderas, we interpret deformation data and build thermal models of Campi Flegrei caldera, Italy. Campi Flegrei experienced at least 4 major unrest episodes in the last decades. Our results indicate that the inflation and deflation of magmatic sources at the same location explain most deformation, at least since the build-up of the last 1538 AD eruption. However, such a repeated magma emplacement requires a persistently hot crust. Our thermal models show that this repeated emplacement was assisted by the thermal anomaly created by magma that was intruded at shallow depth ~3 ka before the last eruption. This may explain the persistence of the magmatic sources promoting the restless behaviour of the Campi Flegrei caldera; moreover, it explains the crystallization, re-melting and mixing among compositionally distinct magmas recorded in young volcanic rocks. Our model of thermally-assisted unrest may have a wider applicability, possibly explaining also the dynamics of other restless calderas.

  3. Salt Repository emplacement mode evaluation and selection: Final report

    International Nuclear Information System (INIS)

    1988-03-01

    This document describes the decision analysis performed to evaluate and compare the emplacement mode for the Salt Repository. The study was commissioned to recommend one emplacement mode to the Salt Repository Project Office using multi-attribute decision analysis. The nature of the decision required analysis of uncertain outcomes and conflicting attributes and offers a high degree of objectivity for these types of decisions since the decision model is structured to allow only the facts to enter into the final decision. The analysis requires an explicit definition of the attributes used to evaluate the alternative (e.g., cost, safety, environmental impact), the definition of a utility function over the attributes which incorporated both risk attitudes and trade-offs between attributes, and the probability distribution over the outcomes that would result from the selection of one alternative over the other. The decision process is described and results are given. A simulation model was developed to evaluate the probability distributions over the attributes. This report documents logic, inputs and results of this model. Final ranking of alternatives is given. Extensive technical backup documentation is included in the appendices to provide the quantitative basis for this decision. 5 refs., 2 figs., 8 tabs

  4. Feedback control of plasma position in the HL-1 tokamak

    International Nuclear Information System (INIS)

    Yuan Baoshan; Jiao Boliang; Yang Kailing

    1991-01-01

    In the HL-1 tokamak with a thick copper shell, the control of plasma position is successfully performed by a feedback-feedforward system with dual mode regulator and the equilibrium field coils outside the shell. The plasma position can be controlled within ±2 mm in both vertical and horizontal directions under the condition that the iron core of transformer is not saturated

  5. Social Cost Benefit Analysis of HL-LHC

    CERN Document Server

    Bastianin, Andrea

    2018-01-01

    We present a Social Cost–Benefit Analysis (CBA) of the High Luminosity upgrade of the Large Hadron Collider (HL-LHC), assessing its economic costs and benefits up to 2038. The Net Present Value (NPV) of the HL-LHC project is positive at the end of the observation period. The ratio between incremental benefits and incremental costs of the HL-LHC with respect to continue operating the LHC under normal consolidation (i.e. without high-luminosity upgrade) is slightly over 1.7, meaning that each Swiss Franc invested in the HL-LHC upgrade project pays back approximately 1.7 CHF in societal benefits. Simulations based on 50000 Monte Carlo rounds show that there is a 94% chance to observe a positive NPV (i.e. a quantifiable economic benefit for the society). The attractiveness of CERN for Early Stage Researchers (ESR) is key for a positive CBA result. Given that benefits to ESRs are the single most important societal benefit, CERN should invest more in activities facilitating the transition to the international job...

  6. Preliminary design of HL-2A discharge control system

    International Nuclear Information System (INIS)

    Jiang Chao; Song Xianming; Li Qiang

    2001-01-01

    HL-2A Discharge Control System consists of one or more VXI work stations so as to compose an all digital control system. The DCS are used to measure and control the poloidal coils, the main tasks of the poloidal coils are exploding, keeping and controlling the current of plasma. These coils explode plasma and keep it in the determined position

  7. Towards Optimum Material Choices for HL-LHC Collimator Upgrade

    CERN Document Server

    Quaranta, E.; Biancacci, N.; Bruce, R.; Carra, F.; Métral, E.; Redaelli, S.; Rossi, A.; Salvant, B.

    2016-01-01

    properties that address different limitations of the present collimation system, solutions have been found to fulfil various upgrade challenges. This paper describes the proposed staged approach to deploy new materials in the upgraded HL-LHC collimation system. Beam tests at the CERN HiRadMat facility were also performed to benchmark simulation methods and constitutive material models.

  8. Connecting HL Tau to the observed exoplanet sample

    Science.gov (United States)

    Simbulan, Christopher; Tamayo, Daniel; Petrovich, Cristobal; Rein, Hanno; Murray, Norman

    2017-08-01

    The Atacama Large Millimeter/submilimeter Array (ALMA) recently revealed a set of nearly concentric gaps in the protoplanetary disc surrounding the young star HL Tauri (HL Tau). If these are carved by forming gas giants, this provides the first set of orbital initial conditions for planets as they emerge from their birth discs. Using N-body integrations, we have followed the evolution of the system for 5 Gyr to explore the possible outcomes. We find that HL Tau initial conditions scaled down to the size of typically observed exoplanet orbits naturally produce several populations in the observed exoplanet sample. First, for a plausible range of planetary masses, we can match the observed eccentricity distribution of dynamically excited radial velocity giant planets with eccentricities >0.2. Secondly, we roughly obtain the observed rate of hot Jupiters around FGK stars. Finally, we obtain a large efficiency of planetary ejections of ≈2 per HL Tau-like system, but the small fraction of stars observed to host giant planets makes it hard to match the rate of free-floating planets inferred from microlensing observations. In view of upcoming Gaia results, we also provide predictions for the expected mutual inclination distribution, which is significantly broader than the absolute inclination distributions typically considered by previous studies.

  9. Experiment of laser thomson scattering at HL-1 tokamak device

    International Nuclear Information System (INIS)

    Zuo Henian; Chen Jiafu; Yan Derong; Liu Aiping; Shi Peilan; Wang Wei; Liu Xiaomei

    1989-05-01

    The structure and performance of the Ruby Laser Thomson Scattering apparatus for HL-1 tokamak device is described. The method of acquisition and calibration of multichannel scattered signals are presented. Examples of measured electron temperature T. with experimental error are given

  10. Formation of secondary phases during the corrosion of vitrified nuclear waste

    International Nuclear Information System (INIS)

    Zimmer, P.

    2003-11-01

    The first aim of this work was the examination of the formation and long-term stability of secondary phases that form during an aquatic attack on simulated, vitrified nuclear waste. In the glasses used for the investigations actinides had been replaced by rare earth elements (chemical analogues), other radionuclides by inactive isotopes. For predictions about the long-term safety of nuclear waste disposals it is important to identify secondary phases that have formed during the glass corrosion process and to determine their stability. Two different saline solutions (rich in MgCl 2 and in NaCl, respectively) are relevant as a corrosion medium for waste disposals. It showed that in such an environment sulfates, silicates and molybdates represent the main new formations of minerals after 7.5 years of corrosion. However, the formation, long-term stability and sorption characteristics of those minerals regarding rare earth elements depend to a high degree on the corrosion medium as well as on changes in the geochemical environment in the course of the experiment. By means of SEM/EDX barytes of different morphology with up to 15% w/w Sr ((Ba,Sr)SO 4 ) were identified in both corrosion media; they were capable of binding long-term stable radionuclides like Sr. Furthermore, pure rare earth (RE) sulfates were observed in the saline solution rich in MgCl 2 . This formation of RE-sulfates has not been described in the literature so far. Depending on the saline solution, the secondary silicate and molybdate minerals that formed on the glass surfaces differed noticeably in their sorption characteristics and their stability. Another focus of the work was a more profound understanding of the glass corrosion mechanism in the presence of metallic iron since steel jackets are used as technical barriers for the vitrified nuclear waste in nuclear waste disposals. Another important point in connection with the mobilization and immobilization of radionuclides released during glass

  11. CLASSIFICATION OF THE MGR WASTE EMPLACEMENT/RETRIEVAL SYSTEM

    International Nuclear Information System (INIS)

    J.A. Ziegler

    2000-01-01

    The purpose of this analysis is to document the Quality Assurance (QA) classification of the Monitored Geologic Repository (MGR) waste emplacement/retrieved system structures, systems and components (SSCs) performed by the MGR Preclosure Safety and Systems Engineering Section. This analysis also provides the basis for revision of YMP/90-55Q, Q-List (YMP 2000). The Q-List identifies those MGR SSCs subject to the requirements of DOE/RW-0333P, Quality Assurance Requirements and Description (QARD) (DOE 2000). This QA classification incorporates the current MGR design and the results of the ''Design Basis Event Frequency and Dose Calculation for Site Recommendation'' (CRWMS M andO 2000a). The content and technical approach of this analysis is in accordance with the development plan ''QA Classification of MGR Structures, Systems, and Components'' (CRWMS M andO 1999b)

  12. Remote excavation using the telerobotic small emplacement excavator

    International Nuclear Information System (INIS)

    Thompson, D.H.; Burks, B.L.; Killough, S.M.

    1993-01-01

    Oak Ridge National Laboratory is developing remote excavation technologies for the Office of Technology Development, Robotics Technology Development Program. This work is being done to meet the need for remote excavation and removal of radioactive and contaminated buried waste at several DOE sites. System requirements are based on the need to uncover and remove waste from burial sites in a way that does not cause unnecessary personnel exposure or additional environmental contamination. Goals for the current project are to demonstrate dexterous control of a backhoe with force feedback and to implement robotic operations that will improve productivity. The Telerobotic Small Emplacement Excavator is a prototype system that incorporates the needed robotic and telerobotic capabilities on a commercially available platform. The ability to add remote dexterous teleoperation and robotic operating modes is intended to be adaptable to other commercially available excavator systems

  13. Chemically durable iron phosphate glasses for vitrifying sodium bearing waste (SBW) using conventional and cold crucible induction melting (CCIM) techniques

    Energy Technology Data Exchange (ETDEWEB)

    Kim, C.W. E-mail: cheol@umr.edu; Ray, C.S.; Zhu, D.; Day, D.E.; Gombert, D.; Aloy, A.; Mogus-Milankovic, A.; Karabulut, M

    2003-11-01

    A simulated sodium bearing waste (SBW) was successfully vitrified in iron phosphate glasses (IPG) at a maximum waste loading of 40 wt% using conventional and cold crucible induction melting (CCIM) techniques. No sulfate segregation or crystalline phases were detectable in the IPG when examined by SEM and XRD. The IPG wasteforms containing 40 wt% SBW satisfy current DOE requirements for aqueous chemical durability as evaluated from their bulk dissolution rate (D{sub R}), product consistency test, and vapor hydration test. The fluid IPG wasteforms can be melted at a relatively low temperature (1000 deg. C) and for short times (<6 h). These properties combined with a significantly higher waste loading, and the feasibility of CCIM melting offer considerable savings in time, energy, and cost for vitrifying the SBW stored at the Idaho National Engineering and Environmental Laboratory in iron phosphate glasses.

  14. Evaluation of the safety of vitrified high level waste shipments from the UK to continental Europe by sea. Annex 2

    International Nuclear Information System (INIS)

    Lange, F.; Fett, H.J.; Hoermann, E.; Roewekamp, M.; Cheshire, R.; Elston, B.; Slawson, G.; Raffestin, D.; Schneider, T.; Armingaud, F.; Laurent, B.

    2001-01-01

    The return of vitrified high level waste arising from the reprocessing of spent nuclear fuel at Sellafield to continental Europe, e.g. Germany, will start around the end of the century. The shipment of the specific flasks will include transportation via the Irish Sea, the English Channel and the North Sea with ships of the Pacific Nuclear Transport Limited (PNTL) classified to the INF 3 standard. The assessment approach is to analyse the severity and the frequency of mechanical impacts, fires and explosions with the potential to affect the package. The results show that there is a high safety margin due to the special safety features of the INF 3 ships compared to conventional ships. The remaining accident probability for a trans-port of vitrified high level waste from UK to the continent is very low. No realistic severe accident scenarios that could seriously affect the flasks and could lead to a radioactivity re-lease have been identified. (author)

  15. Selections from 2016: Gaps in HL Tau's Protoplanetary Disk

    Science.gov (United States)

    Kohler, Susanna

    2016-12-01

    Editors note:In these last two weeks of 2016, well be looking at a few selections that we havent yet discussed on AAS Nova from among the most-downloaded paperspublished in AAS journals this year. The usual posting schedule will resume after the AAS winter meeting.Gas Gaps in the Protoplanetary Disk Around the Young Protostar HL TauPublished March 2016The dust (left) and gas (right) emission from HL Tau show that the gaps in its disk match up. [Yen et al. 2016]Main takeaway:At the end of last year, the Atacama Large Millimeter/Submillimeter Array released some of its first data including a spectacular observation of a dusty protoplanetary disk around the young star HL Tau. In this follow-up study, a team led by Hsi-Wei Yen (Academia Sinica Institute of Astronomy and Astrophysics, Taiwan) analyzed the ALMA data and confirmed the presence of two gaps in the gas of HL Taus disk, at radii of 28 and 69 AU.Why its interesting:The original ALMA image of HL Taus disk suggests the presence of gaps in disk, but scientists werent sure if they were caused by effects like gravitational instabilities or dust clumping, or if the gaps were created by the presence of young planets. Yen and collaborators showed that gaps in the disks gas line up with gaps in its dust, supporting the model in which these gaps have been carved out by newly formed planets.Added intrigue:The evidence for planets in this disk came as a bit of a surprise, since it was originally believed that it takes tens of millions of years to form planets from the dust of protoplanetary disks but HL Tau is only a million years old. These observations therefore suggest that planets start to form much earlier than we thought.CitationHsi-Wei Yen et al 2016 ApJL 820 L25. doi:10.3847/2041-8205/820/2/L25

  16. Novel Emplacement Device for a Very Deep Borehole Disposal

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Min Soo; Choi, Heui-joo; Lee, Jong Yul [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    There is a worldwide attempt of HLW disposal into a very deep borehole of around 3-5 km depth with the advancement of an underground excavation technology recently. As it goes into deeper underground, the rock becomes more uniform and flawless. And then the underground water circulation system at 3-5 km depth is almost disconnected with near groundwater circulation system. The canister integrity is less important in this very deep borehole disposal system unlike a general geologic disposal system at 500 m. In the deep borehole disposal procedures, one SNF (Spent Nuclear Fuel) assembly is stored in one disposal canister (D30-40cm, H4.7-5.0m), and approximately 10-40 disposal canisters are connected axially, which parade length can leach to around 200m in maximum. The connected canister parade is lowered through a very deep borehole (D40-50cm) by emplacement devices. Therefore the connections between canisters and canister to lowering joint are very important for the safe operation of it. The well-known connection method between canisters is Threaded Coupled Connection method, in which releasing of the connection is almost impossible after thread fastening in the borehole. The novel joint device suggested in this paper can accommodate a canister emplacement and retrieval in the borehole disposal process. The joint can be lowered by bound to a drilling pipe, or high tension cable along 3-5 km distance. This novel device can cope with an accidental event easily without any joint head change. When canisters are damaged or stuck on the borehole wall during their descending, the canisters in trouble can be retrieved simply by the control of a lifting speed.

  17. The potential use of transmission tomography techniques for the quality checking of cement encapsulated and vitrified wastes

    International Nuclear Information System (INIS)

    Huddleston, J.; Hutchinson, I.G.; Burch, S.F.; Perring, J.K.

    1989-01-01

    The technique of extracting information from real-time radiographic images and processing that data using tomographic reconstruction methods has been demonstrated using simulated full-sized specimens of encapsulated intermediate level waste and high level vitrified waste. Sections of these objects are produced perpendicular to the plane of the radiographs from which they originate. The resulting section is clearer and more informative than the radiographs for complex specimens. The technique is proposed as a complementary stage to existing radiographic analyses. (author)

  18. Interagency cooperation in the development of a cost-effective transportation and disposal solution for vitrified radium bearing material

    International Nuclear Information System (INIS)

    Smith, M.L.; Nixon, D.A.; Stone, T.J.; Tope, W.G.; Vogel, R.A.; Allen, R.B.; Schofield, W.D.

    1996-01-01

    Fernald radium bearing ore residue waste, stored within Silos 1 and 2 (K-65) and Silo 3 waste, will be vitrified for disposal at the Nevada Test Site (NTS). A comprehensive, parametric evaluation of waste form, shielding requirements, packaging, and transportation alternatives was completed to identify the safest, most cost-effective approach. The impacts of waste loading, waste form, regulatory requirements, NTS waste acceptance criteria, as-low-as-resonably-achievable principles, and material handling costs were factored into the recommended approach. Through cooperative work between the U.S. Department of Energy (DOE) and the U.S. Department of Transportation (DOT), the vitrified K-65 and Silo 3 radioactive material will be classified consistent with the regulations promulgated by DOT in the September 28, 1995 Federal Register. These new regulations adopt International Atomic Energy Agency language to promote a consistent approach for the transportation and management of radioactive material between the international community and the DOT. Use of the new regulations allows classification of the vitrified radioactive material from the Fernald silos under the designation of low specific activity-II and allows the development of a container that is optimized to maximize payload while minimizing internal void space, external surface radiation levels, and external volume. This approach minimizes the required number of containers and shipments, and the related transportation and disposal costs

  19. Interagency cooperation in the development of a cost-effective transportation and disposal solution for vitrified radium bearing material

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.L.; Nixon, D.A.; Stone, T.J.; Tope, W.G.; Vogel, R.A. [Fernald Environmental Restoration Management Corp., Cincinnati, OH (United States); Allen, R.B. [USDOE, Fernald Area Office, Cincinnati, OH (United States); Schofield, W.D. [Foster Wheeler Environmental Corp. (United States)

    1996-02-01

    Fernald radium bearing ore residue waste, stored within Silos 1 and 2 (K-65) and Silo 3 waste, will be vitrified for disposal at the Nevada Test Site (NTS). A comprehensive, parametric evaluation of waste form, shielding requirements, packaging, and transportation alternatives was completed to identify the safest, most cost-effective approach. The impacts of waste loading, waste form, regulatory requirements, NTS waste acceptance criteria, as-low-as-resonably-achievable principles, and material handling costs were factored into the recommended approach. Through cooperative work between the U.S. Department of Energy (DOE) and the U.S. Department of Transportation (DOT), the vitrified K-65 and Silo 3 radioactive material will be classified consistent with the regulations promulgated by DOT in the September 28, 1995 Federal Register. These new regulations adopt International Atomic Energy Agency language to promote a consistent approach for the transportation and management of radioactive material between the international community and the DOT. Use of the new regulations allows classification of the vitrified radioactive material from the Fernald silos under the designation of low specific activity-II and allows the development of a container that is optimized to maximize payload while minimizing internal void space, external surface radiation levels, and external volume. This approach minimizes the required number of containers and shipments, and the related transportation and disposal costs.

  20. Field characterization plan for the 216-U-8 vitrified clay pipeline

    International Nuclear Information System (INIS)

    Rowley, C.A.

    1994-01-01

    The 216-U-8 Crib was constructed in 1952 and received waste from 1952 to 1960 as described in Appendix A. This description of work details the field activities associated with the characterization of the vitrified clay pipe (VCP) delivery line to the 216-U-8 Crib and subsurface soil sampling along the pipe route in the 200 West Area of Hanford U Plant. It will serves as a field guide for those performing the work. Soil sampling locations will be determined by a combination of radiological surface surveys and internal camera surveys of the VCP line. Depending on the condition of the pipeline and field conditions, the objectives are as follows: examine the internal condition of the VCP with a survey camera to the extent allowed by field conditions; determine precise location and depth of the VCP; document VCP integrity; document gamma radiation profile through the VCP; and correlate any relationships between surface contamination zones at grade above the VCP to identify breaches in the pipe integrity

  1. The design and construction of the windscale vitrification plant and vitrified product store

    International Nuclear Information System (INIS)

    Heafield, W.; Woodall, A.; Elsden, A.D.

    1987-01-01

    The paper describes the background of High Level Waste storage and vitrification development in the UK and its application to Reprocessing Operations at Sellafield. The main stages in the vitrification process and associated maintenance facilities are described together with the layout of the Windscale Vitrification Plant (WVP) and associated Vitrified Product Store (VPS). The design and construction techniques employed for example, the use of Computer Aided Design and the effect of automatic pipe bending/orbital welding and the use of precast units for cell construction, are discussed and current construction progress is highlighted. The vitrification process uses complex mechanical plant operating in high temperature and radiation fields. An extensive engineering and process development programme has been carried out. A full scale inactive facility (FSIF) has been constructed and the objectives and results from the operation of FSIF are presented. In addition to engineering and process development, a comprehensive programme of glass technology development has been carried out to establish maximum waste incorporation levels, reaction kinetic and product properties of the candidate glass formulations

  2. Long-term leaching behavior of vitrified high-level wastes

    International Nuclear Information System (INIS)

    Ishiguro, Katsuhiko; Sonobe, Hitoshi; Sasaki, Noriaki; Kashihara, Hidechiyo

    1985-01-01

    A long-term Soxhlet leaching test, long-term static leaching test, solubility evaluation test and actual-scale glass solid leaching test were carried out for simulated vitrified wastes. Under high flow-rate leachate conditions, the leaching of high-solubility substances such as B and Na increases almost linearly with time while that of Fe, Ni and rare earth metals strongly depends on their solubility. The overall leaching rate changes (tends to decrease) with time under static conditions. The elution or diffusion is the rate determining step in the earlier region of the leaching process while the solubilities of major components have greater effects in the latter region. The change of the dominant leaching mechanism is delayed more largely as the surface-area to leachate-volume (SA/V) ratio decreases. Actual-scale glass specimens showed almost the same leaching behaviors as small-scale ones. If cracks exist in glass solid, the leaching in them is slow causing little effects on the overall leaching rate. This may be due to the fact that solubility-dependent leaching is occuring in the cracks. The long-term static leaching observations were not satisfactorily explained by the MCC-3 type solubility test results. It is important to clarify the solubility-dependent leaching behaviors at large SA/V ratios. (Nogami, K.)

  3. Dry storage technologies: Optimized solutions for spent fuels and vitrified residues

    International Nuclear Information System (INIS)

    Roland, Vincent; Verdier, Antoine; Sicard, Damien; Neider, Tara

    2006-01-01

    ancillary equipment, Ready to move to final or centralized repository or reprocessing facility or other ISFSI, Compact systems, Easy rearrangement, Easy handling; - In favor of concrete shielded canisters based systems: Economics when initial quantity is sufficient to spread out up front equipment investment significant cost - Shielding advantage, Easy local production of the relatively light canisters. Both approaches of dry storage technologies can have a positive impact on their public acceptance because of their non-permanent characteristics and because their transport license refers to internationally recognized rules, standards and methods. Currently, more than 1,000 COGEMA Logistics/Transnuclear Inc. dry storage systems have been ordered in Belgium, Germany, Japan, Switzerland, Armenia and the US. Because of the evolution of burnup of spent fuel to be reprocessed, the high activity vitrified residues cannot be transported in the existing cask designs presently used. Therefore, COGEMA LOGISTICS has decided in the late nineties to develop a brand new design of casks with optimized capacity able to store and transport the most active and hottest canisters: the TN TM 81 casks currently in use in Switzerland and the TN TM 85 cask which shall permit in the near future in Germany the storage and the transport of the most active vitrified residues. The TN TM 81 and the TN TM 85 casks have been designed to fully anticipate shipment constraints of the present vitrified residue production in existing reprocessing facilities. They also used the feedback of current shipments and the operational constraints and experience of receiving and shipping facilities. The casks had to fit as much as possible in the existing procedures for the already existing casks such as the TN TM 28 cask and TS 28 V cask, all along the logistics chain of loading, unloading, transport and maintenance. In addition, years of feedback and experience in design and operations - together with ever improved

  4. Risk analysis of transporting vitrified high-level radioactive waste by train

    International Nuclear Information System (INIS)

    Schneider, K.A.; Merz, E.

    1983-01-01

    Reprocessing plants (RPPs) and final disposal sites for vitrified high level radioactive waste (HLW) will be at distant locations in the Federal Republic of Germany (FRG). HLW will also have to be shipped from RPPs located in foreign countries to a final disposal site in the FRG. Thus transportation of HLW on public routes will become necessary. A model of an HLW shipping system is presented which meets the needs of an established nuclear industry. Reference ages of the HLW were assumed to range between about 5 years and about 50 years. Thus HLW shipping systems covering this period are analyzed. The safety of nuclear installations is ensured by means of a design according to the design based accident. The same applies to shipping casks for radioactive materials (RAM) according to the IAEA Regulations. The aim of this work was to make as complete as reasonably possible an estimate of the risk of shipping HLW. The safety of the system was therefore analyzed by means of probabilistic risk assessment. Release of radioactive material due to transportation accidents is considered. 5 references, 5 figures, 6 tables

  5. Methods of vitrifying waste with low melting high lithia glass compositions

    Science.gov (United States)

    Jantzen, Carol M.; Pickett, John B.; Cicero-Herman, Connie A.; Marra, James C.

    2001-01-01

    The invention relates to methods of vitrifying waste and for lowering the melting point of glass forming systems by including lithia formers in the glass forming composition in significant amounts, typically from about 0.16 wt % to about 11 wt %, based on the total glass forming oxides. The lithia is typically included as a replacement for alkali oxide glass formers that would normally be present in a particular glass forming system. Replacement can occur on a mole percent or weight percent basis, and typically results in a composition wherein lithia forms about 10 wt % to about 100 wt % of the alkali oxide glass formers present in the composition. The present invention also relates to the high lithia glass compositions formed by these methods. The invention is useful for stabilization of numerous types of waste materials, including aqueous waste streams, sludge solids, mixtures of aqueous supernate and sludge solids, combinations of spent filter aids from waste water treatment and waste sludges, supernate alone, incinerator ash, incinerator offgas blowdown, or combinations thereof, geological mine tailings and sludges, asbestos, inorganic filter media, cement waste forms in need of remediation, spent or partially spent ion exchange resins or zeolites, contaminated soils, lead paint, etc. The decrease in melting point achieved by the present invention desirably prevents volatilization of hazardous or radioactive species during vitrification.

  6. Sintered glass ceramic composites from vitrified municipal solid waste bottom ashes

    International Nuclear Information System (INIS)

    Aloisi, Mirko; Karamanov, Alexander; Taglieri, Giuliana; Ferrante, Fabiola; Pelino, Mario

    2006-01-01

    A glass ceramic composite was obtained by sinter-crystallisation of vitrified municipal solid waste bottom ashes with the addition of various percentages of alumina waste. The sintering was investigated by differential dilatometry and the crystallisation of the glass particles by differential thermal analysis. The crystalline phases produced by the thermal treatment were identified by X-ray diffraction analysis. The sintering process was found to be affected by the alumina addition and inhibited by the beginning of the crystal-phase precipitation. Scanning electron microscopy was performed on the fractured sintered samples to observe the effect of the sintering. Young's modulus and the mechanical strength of the sintered glass ceramic and composites were determined at different heating rates. The application of high heating rate and the addition of alumina powder improved the mechanical properties. Compared to the sintered glass ceramic without additives, the bending strength and the Young's modulus obtained at 20 deg. C/min, increased by about 20% and 30%, respectively

  7. Transfer shuttle for vitrified residue canisters control of risks associated with external exposure and heat release

    Energy Technology Data Exchange (ETDEWEB)

    BIndel, L.; Gamess, A.; Lejeune, E.; Cellier, P.; Maillard, A. [SGN Reseau Eurisys, 78 - Saint Quentin (France)

    1998-07-01

    In the La Hague COGEMA's plant area, nuclear residue isolated by reprocessing are transported by means of specific transfer shuttles between the different processing and/or conditioning facilities and the storage ones. These shuttles are designed by reference to the applicable dose equivalent rate (DER) limits for transport on the site and the thermal behavior limitations of certain mechanical components which guarantee the containment of the transported waste. This paper describes and example of a study conducted on a transfer shuttle for vitrified residue canisters. Concerning the control of risks associated with external exposure and with heat releases, these were handled by the 'Shielding-Criticality-Dispersion' and 'process Modelling and Simulation' Sections of the Technical Division of SGN. The dose profiles around the shuttle, as a function of the shielding heterogeneities and possible radiation leakage, as well as the thermal fields within the shuttle, were calculated using 3D models. These design studies ultimately helped to select and validate the optimal solutions. (authors)

  8. Cryo-electron microscopy of vitrified SV40 minichromosomes: the liquid drop model.

    Science.gov (United States)

    Dubochet, J; Adrian, M; Schultz, P; Oudet, P

    1986-03-01

    The structure of SV40 minichromosomes has been studied by cryo-electron microscopy of vitrified thin layers of solution. In high-salt buffer (130 mM NaCl), freshly prepared minichromosomes are condensed into globules 30 nm or more in diameter. On the micrograph, they appear to be formed by the close packing of 10 nm granules which give rise to a 10 nm reflection in the optical diffractogram. The globules can adopt many different conformations. At high concentration, they fuse into a homogeneous 'sea' of closely packed 10 nm granules. In low-salt buffer (less than 10 mM NaCl), the globules open, first into 10 nm filaments, and then into nucleosome-strings. The 'liquid drop' model is proposed to explain the condensed structure of the minichromosome in high-salt buffer: nucleosomes stack specifically on top of one another, thus forming the 10 nm filaments. 10 nm filaments in turn, tend to aggregate laterally. Optimizing both these interactions results in the condensation of 10 nm filaments or portions thereof into a structure similar to that of a liquid. Some implications of this model for the structure of cellular chromatin are discussed.

  9. Waste acceptance and waste loading for vitrified Oak Ridge tank waste

    International Nuclear Information System (INIS)

    Harbour, J.R.; Andrews, M.K.

    1997-01-01

    The Office of Science and Technology of the DOE has funded a joint project between the Oak Ridge National Laboratory (ORNL) and the Savannah River Technology Center (SRTC) to evaluate vitrification and grouting for the immobilization of sludge from ORNL tank farms. The radioactive waste is from the Gunite and Associated Tanks (GAAT), the Melton Valley Storage Tanks (MVST), the Bethel Valley Evaporator Service Tanks (BVEST), and the Old Hydrofractgure Tanks (OHF). Glass formulation development for sludge from these tanks is discussed in an accompanying article for this conference (Andrews and Workman). The sludges contain transuranic radionuclides at levels which will make the glass waste form (at reasonable waste loadings) TRU. Therefore, one of the objectives for this project was to ensure that the vitrified waste form could be disposed of at the Waste Isolation Pilot Plant (WIPP). In order to accomplish this, the waste form must meet the WIPP Waste Acceptance Criteria (WAC). An alternate pathway is to send the glass waste forms for disposal at the Nevada Test Site (NTS). A sludge waste loading in the feed of 6 wt percent will lead to a waste form which is non-TRU and could potentially be disposed of at NTS. The waste forms would then have to meet the requirements of the NTS WAC. This paper presents SRTC''s efforts at demonstrating that the glass waste form produced as a result of vitrification of ORNL sludge will meet all the criteria of the WIPP WAC or NTS WAC

  10. Electrochemical reduction behavior of simplified simulants of vitrified radioactive waste in molten CaCl2

    Science.gov (United States)

    Katasho, Yumi; Yasuda, Kouji; Nohira, Toshiyuki

    2018-05-01

    The electrochemical reduction of two types of simplified simulants of vitrified radioactive waste, simulant 1 (glass component only: SiO2, B2O3, Na2O, Al2O3, CaO, Li2O, and ZnO) and simulant 2 (also containing long-lived fission product oxides, ZrO2, Cs2O, PdO, and SeO2), was investigated in molten CaCl2 at 1103 K. The behavior of each element was predicted from the potential-pO2- diagram constructed from thermodynamic data. After the immersion of simulant 1 into molten CaCl2 without electrolysis, the dissolution of Na, Li, and Cs was confirmed by inductively coupled plasma atomic emission spectrometry and mass spectrometry analysis of the samples. The scanning electron microscopy/energy dispersive X-ray and X-ray diffraction analyses of simulants 1 and 2 electrolyzed at 0.9 V vs. Ca2+/Ca confirmed that most of SiO2 had been reduced to Si. After the electrolysis of simulants 1 and 2, Al, Zr, and Pd remained in the solid phase. In addition, SeO2 was found to remain partially in the solid phase and partially evaporate, although a small quantity dissolved into the molten salt.

  11. A Review of Iron Phosphate Glasses and Recommendations for Vitrifying Hanford Waste

    Energy Technology Data Exchange (ETDEWEB)

    Delbert E. Ray; Chandra S. Ray

    2013-11-01

    This report contains a comprehensive review of the research conducted, world-wide, on iron phosphate glass over the past ~30 years. Special attention is devoted to those iron phosphate glass compositions which have been formulated for the purpose of vitrifying numerous types of nuclear waste, with special emphasis on the wastes stored in the underground tanks at Hanford WA. Data for the structural, chemical, and physical properties of iron phosphate waste forms are reviewed for the purpose of understanding their (a) outstanding chemical durability which meets all current DOE requirements, (b) high waste loadings which can exceed 40 wt% (up to 75 wt%) for several Hanford wastes, (c) low melting temperatures, can be as low as 900°C for certain wastes, and (d) high tolerance for “problem” waste components such as sulfates, halides, and heavy metals (chromium, actinides, noble metals, etc.). Several recommendations are given for actions that are necessary to smoothly integrate iron phosphate glass technology into the present waste treatment plans and vitrification facilities at Hanford.

  12. Effects of High Hydrostatic Pressure on Expression Profiles of In Vitro Produced Vitrified Bovine Blastocysts

    Science.gov (United States)

    Jiang, Zongliang; Harrington, Patrick; Zhang, Ming; Marjani, Sadie L.; Park, Joonghoon; Kuo, Lynn; Pribenszky, Csaba; Tian, Xiuchun (Cindy)

    2016-01-01

    High hydrostatic pressure (HHP) has been used to pre-condition embryos before essential, yet potentially detrimental procedures such as cryopreservation. However, the mechanisms for HHP are poorly understood. We treated bovine blastocysts with three different HHP (40, 60 and 80 MPa) in combination with three recovery periods (0, 1 h, 2 h post HHP). Re-expansion rates were significantly higher at 40 and 60 but lower at 80 MPa after vitrification-warming in the treated groups than controls. Microarray analysis revealed 399 differentially expressed transcripts, representing 254 unique genes, among different groups. Gene ontology analysis indicated that HHP at 40 and 60 MPa promoted embryo competence through down-regulation of genes in cell death and apoptosis, and up-regulation of genes in RNA processing, cellular growth and proliferation. In contrast, 80 MPa up-regulated genes in apoptosis, and down-regulated protein folding and cell cycle-related genes. Moreover, gene expression was also influenced by the length of the recovery time after HHP. The significantly over-represented categories were apoptosis and cell death in the 1 h group, and protein folding, response to unfolded protein and cell cycle in the 2 h group compared to 0 h. Taken together, HHP promotes competence of vitrified bovine blastocysts through modest transcriptional changes. PMID:26883277

  13. Development of a unit cell model for interim performance assessment of vitrified low level waste disposal

    International Nuclear Information System (INIS)

    Kline, N.W.

    1995-09-01

    The unit cell modeling approach has been developed and used in analysis of some design options for a vitrified low level waste disposal facility. The unit cell modeling approach is likely to be useful in interim performance assessment for the facility. The present unit cell model will probably need to be refitted in terms of some model parameters for the latter purpose. Two present disposal facility concepts differ in the length of a capillary barrier proposed to limit effective recharge through the top of the facility. Results of the study summarized herein suggest design of a capillary barrier which can reduce a recharge rate of 0.1 cm/yr by one or two orders of magnitude seems feasible for both concepts. A benchmark comparison of the unit cell model against a full facility model shows comparable predictive accuracy in less than one percent of the computer time. Results suggest that model parameters include capillary barrier performance, inter-canister spacing, rate of moisture withdrawal due to glass corrosion, contaminant inventory, and the well interceptor factor. It is also important that variations of waste form hydraulic parameters suggest that transport through the waste form is dominated by diffusion

  14. Physics potential of ATLAS upgrades at HL-LHC

    CERN Document Server

    Testa, Marianna; The ATLAS collaboration

    2017-01-01

    The High Luminosity-Large Hadron Collider (HL-LHC) is expected to start in 2026 and to pro- vide an integrated luminosity of 3000 fb−1 in ten years, a factor 10 more than what will be collected by 2023. This high statistics will allow ATLAS to perform precise measurements in the Higgs sector and improve searches for new physics at the TeV scale. The luminosity needed is L ∼ 7.51034 cm−2 s−1, corresponding to ∼200 additional proton-proton pile- up interactions. To face such harsh environment some sub-detectors of the ATLAS experiment will be upgraded or completely substituted. The performances of the new or upgraded ATLAS sub-detectors are presented, focusing in particular on the new inner tracker and a proposed high granularity time device. The impact of those upgrades on crucial physics measurements for HL-LHC program is also shown.

  15. Recent advances in the HL-2A tokamak experiments

    International Nuclear Information System (INIS)

    Liu, Y.; Ding, X.T.; Yang, Q.W.; Yan, L.W.; Liu, D.Q.; Xuan, W.M.; Chen, L.Y.; Song, X.M.; Cao, Z.; Zhang, J.H.; Mao, W.C.; Zhou, C.P.; Li, X.D.; Wang, S.J.; Yan, J.C.; Bu, M.N.; Chen, Y.H.; Cui, C.H.; Cui, Z.Y.; Deng, Z.C.; Hong, W.Y.; Hu, H.T.; Huang, Y.; Kang, Z.H.; Li, B.; Li, W.; Li, F.Z.; Li, G.S.; Li, H.J.; Li, Q.; Li, Y.G.; Li, Z.J.; Liu, Yi; Liu, Z.T.; Luo, C.W.; Mao, X.H.; Pan, Y.D.; Rao, J.; Shao, K.; Song, X.Y.; Wang, M.; Wang, M.X.; Wang, Q.M.; Xiao, Z.G.; Xie, Y.F.; Yao, L.H.; Yao, L.Y.; Zheng, Y.J.; Zhong, G.W.; Zhou, Y.; Pan, C.H.

    2005-01-01

    Two experiment campaigns were conducted on the HL-2A tokamak in 2003 and 2004 after the first plasma was obtained at the end of 2002. Progresses in many aspects have been made, especially in the divertor discharge and feedback control of plasma configuration. Up to now, the following operation parameters have been achieved: I p = 320 kA, B t = 2.2 T and discharge duration T d = 1580 ms. With the feedback control of plasma current and horizontal position, an excellent repeatability of the discharge has been achieved. The tokamak has been operated at both limiter configuration and single null (SN) divertor configuration. The HL-2A SN divertor configuration is simulated with the MHD equilibrium code SWEQU. When the divertor configuration is formed, the impurity radiation in the main plasma decreases remarkably

  16. The CMS High Granularity Calorimeter for HL-LHC

    CERN Document Server

    Mastrolorenzo, Luca

    2017-01-01

    The High Luminosity LHC (HL-LHC) will integrate 10 times more luminosity than the LHC, posing significant challenges for radiation tolerance and event pileup on detectors, especially for forward calorimetry, and hallmarks the issue for future colliders. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (ECAL) and hadronic (HCAL) compartments. This will facilitate particle-flow calorimetry, where the fine structure of showers can be measured and used to enhance pileup rejection and particle identification, whilst still achieving good energy resolution. The ECAL and a large fraction of HCAL will be based on hexagonal silicon sensors of 0.5 - 1 cm$^2$ cell size, with the remainder of the HCAL based on highly-segmented scintillators with SiPM readout. The intrinsic high-precision timing capabilities of the silicon sensors wi...

  17. The CMS HGCAL detector for the HL-LHC upgrade

    CERN Document Server

    Steen, Arnaud

    2017-01-01

    The High Luminosity LHC (HL-LHC) will integrate 10 times more luminosity than the LHC, posing significant challenges for radiation tolerance and event pileup on detectors, especially for forward calorimetry, and hallmarks the issue for future colliders. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (ECAL) and hadronic (HCAL) compartments. This will facilitate particle-flow calorimetry, where the fine structure of showers can be measured and used to enhance pileup rejection and particle identification, whilst still achieving good energy resolution. The ECAL and a large fraction of HCAL will be based on hexagonal silicon sensors of 0.5 - 1 cm$^2$ cell size, with the remainder of the HCAL based on highly-segmented scintillators with SiPM readout. The intrinsic high-precision timing capabilities of the silicon sensors wi...

  18. The CMS HGCAL detector for HL-LHC upgrade

    CERN Document Server

    Martelli, Arabella

    2017-01-01

    The High Luminosity LHC (HL-LHC) will integrate 10 times more luminosity than the LHC, posing significant challenges for radiation tolerance and event pileup on detectors, especially for forward calorimetry, and hallmarks the issue for future colliders. As part of its HL-LHC upgrade program, the CMS collaboration is designing a High Granularity Calorimeter to replace the existing endcap calorimeters. It features unprecedented transverse and longitudinal segmentation for both electromagnetic (ECAL) and hadronic (HCAL) compartments. This will facilitate particle-flow calorimetry, where the fine structure of showers can be measured and used to enhance pileup rejection and particle identification, whilst still achieving good energy resolution. The ECAL and a large fraction of HCAL will be based on hexagonal silicon sensors of 0.5 - 1 cm$^2$ cell size, with the remainder of the HCAL based on highly-segmented scintillators with SiPM readout. The intrinsic high-precision timing capabilities of the silicon sensors wi...

  19. Commissioning and preliminary operation of HL-2A tokamak

    International Nuclear Information System (INIS)

    Liu Dequan; Liu Yong; Yan Jianchen; Cao Zeng; Yang Qingwei; Zhou Caipin; Li Xiaodong

    2005-01-01

    HL-2A is a divertor tokamak located at new site of Southwestern Institute of Physics (SWIP), Chengdu, China. It can be operated in double-null and single-null divertor with closed configurations. The effects of the divertor on impurity behaviors, MHD instabilities, transport, wall conditioning and divertor physics are key issues to be studied during the first step operation on HL-2A. Preliminary experiments with limiter and single null divertor configurations were carried out in 2003. Main parameters achieved are the plasma current 168 KA, duration time of 920 ms and plasma linear-averaged density of 1.7 x 10 19 m -3 . The impurities, especially of low Z, are clearly decreased during the divertor experiments

  20. Will ALICE run in the HL-LHC era?

    International Nuclear Information System (INIS)

    Wessels, J.P.

    2012-01-01

    We will present the perspectives for ion running in the HL-LHC era. In particular, ALICE is preparing a significant upgrade of its rate capabilities and is further extending its particle identification potential. This paves the way for heavy ion physics at unprecedented luminosities, which are expected in the HL-LHC era with the heaviest ions. Here, we outline a scenario, in which ALICE will be taking data at a luminosity of L > 6*10 27 cm -2 *s -1 for Pb-Pb with the aim of collecting at least 10 nb -1 . The potential interest of data-taking during high luminosity proton runs for ATLAS and CMS will also be commented. (author)

  1. Pixel DAQ and trigger for HL-LHC

    International Nuclear Information System (INIS)

    Morettini, P.

    2017-01-01

    The read-out is one of the challenges in the design of a pixel detector for the High Luminosity upgrade of the Large Hadron Collider (HL-LHC), that is expected to operate from 2026 at a leveled luminosity of 5 × 10 34  cm −2  s −1 . This is especially true if tracking information is needed in a low latency trigger system. The difficulties of a fast read-out will be reviewed, and possible strategies explained. The solutions that are being evaluated by the ATLAS and CMS collaborations for the upgrade of their trackers will be outlined and ideas on possible development beyond HL-LHC will be presented.

  2. The ohmic heating power supply for HL-1 tokamak

    International Nuclear Information System (INIS)

    Mingrui, Z.; Jiashun, C.

    1986-01-01

    A combination of capacitor banks, inductor and DC Fly wheel-Generator sets are used as ohmic heating power supply (OHPS) for HL-1, which is the largest tokamak in China. This system can give changeable waveform of current in a simple way, because of the use of protection for capacitor banks by changeable connection in easy way. Since the technology of forced zero current in the commutating breaker and synchronous self-triggering crowbar are used, the smooth conversion between the wave front provided by discharge of the capacitor banks and the flat top sustained by the inductor and flywheel realized. The performance of the system was tested by a dummy load and the system has been used in the HL-1 experiments. It is confirmed that this system is sufficiently available for the ohmic heating and has important effects on the long plasma lasting time on the order of 1 sec

  3. Performance and Operational Aspects of HL-LHC Scenarios

    CERN Document Server

    Medina Medrano, Luis

    2016-01-01

    Several alternatives to the present HL-LHC baseline configuration have been proposed, aiming either to improve the potential performance, reduce its risks, or to provide options for addressing possible limitations or changes in its parameters. In this paper we review and compare the performance of the HL-LHC baseline and the main alternatives with the latest parameters set. The results are obtained using refined simulations of the evolution of the luminosity with β^{*}-levelling, for which new criteria have been introduced, such as improved calculation of the intrabeam scattering and the addition of penalty steps to take into account the necessary time to move between consecutive optics during the process. The features of the set of optics are discussed for the nominal baseline.

  4. Data Warehouse Design from HL7 Clinical Document Architecture Schema.

    Science.gov (United States)

    Pecoraro, Fabrizio; Luzi, Daniela; Ricci, Fabrizio L

    2015-01-01

    This paper proposes a semi-automatic approach to extract clinical information structured in a HL7 Clinical Document Architecture (CDA) and transform it in a data warehouse dimensional model schema. It is based on a conceptual framework published in a previous work that maps the dimensional model primitives with CDA elements. Its feasibility is demonstrated providing a case study based on the analysis of vital signs gathered during laboratory tests.

  5. B-physics studies for HL-LHC ATLAS upgrade

    CERN Document Server

    Jakoubek, Tomas; The ATLAS collaboration

    2017-01-01

    Simulation studies were made to estimate ATLAS HL-LHC upgrade performance for B-physics. In particular, the decay of $B_s^0 \\to J/\\psi\\phi$ is studied in order to measures the $CP$ violating mixing phase and the width difference between the $B_s^0$ eigenstates. The increased sensitivity is related mainly to the improved decay time resolution obtained with the upgraded ITk inner tracking detector.

  6. Searches for electroweak SUSY with ATLAS at HL-LHC

    CERN Document Server

    Amoroso, Simone; The ATLAS collaboration

    2018-01-01

    The High Luminosity-Large Hadron Collider (HL-LHC) is expected to start in 2026 and to pro- vide an integrated luminosity of 3000 fb$^{−1}$ in ten years, a factor 10 more than what will be collected by 2023. This high statistics will allow ATLAS to improve searches for new physics at the TeV scale. In this talk search prospects for the electroweak production of supersymmetric particles are presented.

  7. Observation of electron temperature profile in HL-1M tokamak

    International Nuclear Information System (INIS)

    Cao Jianyong; Xu Deming; Ding Xuantong

    2000-01-01

    The principle and method of the electron temperature measurement by means of electron cyclotron emission (ECE) have been described. Several results under different conditions on HL-1M tokamak have been given. The hollow profile of electron temperature appears in some stages, such as current rising, pellet injection and impurity concentration in the plasma centre. When the bias voltage is applied, the electron temperature profile become steeper. All of the phenomena are related with the transport in plasma centre

  8. The CMS Outer Tracker for HL-LHC

    CERN Document Server

    Dierlamm, Alexander Hermann

    2018-01-01

    The LHC is planning an upgrade program, which will bring the luminosity to about $5-7\\times10^{34}$~cm$^{-2}$s$^{-1}$ in 2026, with a goal of an integrated luminosity of 3000 fb$^{-1}$ by the end of 2037. This High Luminosity LHC scenario, HL-LHC, will require a preparation program of the LHC detectors known as Phase-2 Upgrade. The current CMS Tracker is already running beyond design specifications and will not be able to cope with the HL-LHC radiation conditions. CMS will need a completely new Tracker in order to fully exploit the highly demanding operating conditions and the delivered luminosity. The new Outer Tracker system is designed to provide robust tracking as well as Level-1 trigger capabilities using closely spaced modules composed of silicon macro-pixel and/or strip sensors. Research and development activities are ongoing to explore options and develop module components and designs for the HL-LHC environment. The design choices for the CMS Outer Tracker Upgrade are discussed along with some highlig...

  9. Physics prospects at the HL-LHC with ATLAS

    CERN Document Server

    Duncan, Anna Kathryn

    2017-01-01

    The High-Luminosity LHC aims to provide a total integrated luminosity of 3000 fb$^{-1}$ from proton-proton collisions at $\\sqrt{s}$ = 14 TeV over the course of $\\sim$ 10 years, reaching instantaneous luminosities of up to $L = 7.5 \\times 10^{34} cm^{-2} s^{-1}$, corresponding to an average of 200 inelastic p-p collisions per bunch crossing ($\\mu = 200)$. The upgraded ATLAS detector and trigger system must be able to cope well with increased occupancies and data rates. The performance of the upgrade has been estimated in full simulation studies, assuming expected HL-LHC conditions and a detector configuration intended to maximise physics performance and discovery potential at the HL-LHC, and is expected to be similar to current performance. Fast simulation studies have been carried out to evaluate the prospects of various benchmark physics analyses to be performed using the upgraded ATLAS detector with the full HL-LHC dataset.

  10. Effect of citrus flavonoids on HL-60 cell differentiation.

    Science.gov (United States)

    Kawaii, S; Tomono, Y; Katase, E; Ogawa, K; Yano, M

    1999-01-01

    Twenty-seven Citrus flavonoids were examined for their activity of induction of terminal differentiation of human promyelocytic leukemia cells (HL-60) by nitro blue tetrazolium (NBT) reducing, nonspecific esterase, specific esterase, and phagocytic activities. 10 flavonoids were judged to be active (percentage of NBT reducing cells was more than 40% at a concentration of 40 microM), and the rank order of potency was natsudaidain, luteolin, tangeretin, quercetin, apigenin, 3, 3, '4, '5, 6, 7, 8-heptamethoxyflavone, nobiletin, acacetin, eriodictyol, and taxifolin. These flavonoids exerted their activity in a dose-dependent manner. HL-60 cells treated with these flavonoids differentiated into mature monocyte/macrophage. The structure-activity relationship established from comparison between flavones and flavanones revealed that ortho-catechol moiety in ring B and C2-C3 double bond had an important role for induction of differentiation of HL-60. In polymethoxylated flavones, hydroxyl group at C3 and methoxyl group at C8 enhanced the differentiation-inducing activity.

  11. Design for effective development and prototyping of the HL-20

    Science.gov (United States)

    Urie, David M.; Floreck, Paul A.; McMorris, John A.; Elvin, John D.

    1993-10-01

    A feasibility study of the HL-20 personnel launch system (PLS) concept was conducted by a team which focused on creating a PLS design approach and an accelerated development plan consistent with the historical 'Skunk Works' approach to rapid prototyping. Technical design, manufacturing, system testing, and operations and support elements of the predefined baseline concept were evaluated. An initial phase program, featuring a concurrent system test during design and development, leading to the orbital flight of an unmanned HL-20 prototype on a Titan III launch system, was prescribed. A second-phase development and manufacturing plan leading to system operational status was also formulated. Baseline design feature modifications were made when necessary, without compromise to performance, to satisfy the prototype development plan. Technical design details and off-the-shelf hardware candidates were also identified for several subsystems, including the launch-system interface adapter/emergency escape system. The technical feasibility of the system and applicability of the Skunk Works approach to development of the HL-20/PLS were verified.

  12. Organizing a complex transport while guaranteeing safety and transparency: the example of vitrified wastes sent back to Germany

    International Nuclear Information System (INIS)

    Krochmaluk, Julie; Lebrun, Marc; Delmestre, Alain; Barbey, Pierre; Bonvalot, Vanessa; Belleville, Didier; Rollinger, Patrice; Alter, Ulrich

    2012-01-01

    This chapter is made of several small articles entitled: - 'Les controles avant le depart du convoi franco-allemand' (Controls before the departure of the French-German convoy); - 'La supervision des transports de matieres radioactives: une approche extensive de la surete des operations' (The supervision of radioactive material transports: an extended approach of operation safety); - 'Le dispositif d'information du public sur le transport des substances radioactives mis en place par l'ASN' (The plan implemented by the ASN for public information on nuclear materials transport); - 'Le recours de l'ASN a l'expertise de l'ACRO sur le convoi de colis de dechets vitrifies vers l'Allemagne' (The appeal of the ASN to the ACRO's expertise on the vitrified parcel convoy to Germany); - 'La participation du collectif STOP-EPR a l'inspection de l'ASN du convoi de colis de dechets vitrifies vers l'Allemagne' (The participation of the STOP-EPR collective to the control by the ASN of the vitrified parcel convoy to Germany); - 'La securite et la surete: des valeurs que le Groupe SNCF partage' (Security and safety: values which are shared by the SNCF Group); - 'Le transport de matieres nucleaires entre la France et l'Allemagne au cours des 40 dernieres annees' (Transport of nuclear materials between France and Germany during the last 40 years). Addressing the case of vitrified wastes transported back to Germany, the articles indicate the controls performed in France before convoy departure, discuss the approach adopted for the safety of radioactive material transport, comment the management of public information by the ASN for such transports, comment the intervention of the ACRO (Association for the control of radioactivity in western France) on the request of the ASN and the participation of a collective group (STOP-EPR) to the inspection of a convoy, outline the commitment of the French Railways (SNCF) in terms of security and safety, and give a qualitative and quantitative

  13. Granite ascent and emplacement during contractional deformation in convergent orogens

    Science.gov (United States)

    Brown, Michael; Solar, Gary S.

    1998-09-01

    Based on a case study in the Central Maine Belt of west-central Maine, U.S.A., it is proposed that crustal-scale shear zone systems provide an effective focussing mechanism for transfer of granite melt through the crust in convergent orogens. During contractional deformation, flow of melt in crustal materials at depths below the brittle-plastic transition is coupled with plastic deformation of these materials. The flow is driven by pressure gradients generated by buoyancy forces and tectonic stresses. Within the oblique-reverse Central Maine Belt shear zone system, stromatic migmatite and concordant to weakly discordant irregular granite sheets occur in zones of higher strain, which suggests percolative flow of melt to form the migmatite leucosomes and viscous flow of melt channelized in sheet-like bodies, possibly along fractures. Cyclic fluctuations of melt pressure may cause instantaneous changes in the effective permeability of the flow network if self-propagating melt-filled tensile and/or dilatant shear fractures are produced due to melt-enhanced embrittlement. Inhomogeneous migmatite and schlieric granite occur in zones of lower strain, which suggests migration of partially-molten material through these zones en masse by granular flow, and channelized flow of melt carrying entrained residue. Founded on the Central Maine Belt case study, we develop a model of melt extraction and ascent using the driving forces, stress conditions and crustal rheologies in convergent, especially transpressive orogens. Ascent of melt becomes inhibited with decreasing depth as the solidus is approached. For intermediate a(H 2O) muscovite-dehydration melting, the water-saturated solidus occurs between 400 and 200 MPa, near the brittle-plastic transition during high- T-low- P metamorphism, where the balance of forces favors (sub-) horizontal fracture propagation. Emplacement of melt may be accommodated by ductile flow and/or stoping of wall rock, and inflation may be accommodated

  14. Evidence for Transfer of Membranes from Mesenchymal Stem Cells to HL-1 Cardiac Cells.

    Science.gov (United States)

    Boomsma, Robert A; Geenen, David L

    2014-01-01

    This study examined the interaction of mouse bone marrow mesenchymal stem cells (MSC) with cardiac HL-1 cells during coculture by fluorescent dye labeling and then flow cytometry. MSC were layered onto confluent HL-1 cell cultures in a 1 : 4 ratio. MSC gained gap junction permeant calcein from HL-1 cells after 4 hours which was partially reduced by oleamide. After 20 hours, 99% MSC gained calcein, unaffected by oleamide. Double-labeling HL-1 cells with calcein and the membrane dye DiO resulted in transfer of both calcein and DiO to MSC. When HL-1 cells were labeled with calcein and MSC with DiO, MSC gained calcein while HL-1 cells gained DiO. Very little fusion was observed since more than 90% Sca-1 positive MSC gained DiO from HL-1 cells while less than 9% gained gap junction impermeant CMFDA after 20 hours with no Sca-1 transfer to HL-1 cells. Time dependent transfer of membrane DiD was observed from HL-1 cells to MSC (100%) and vice versa (50%) after 20 hours with more limited transfer of CMFDA. These results demonstrate that MSC and HL-1 cells exchange membrane components which may account for some of the beneficial effect of MSC in the heart after myocardial infarction.

  15. Recurrent uranium relocations in distal turbidites emplaced in pelagic conditions

    International Nuclear Information System (INIS)

    Colley, S.; Thomson, J.

    1985-01-01

    The sediments of the Madeira Abyssal Plain, east of Great Meteor Seamount, are dominated by distal turbidite deposition. While the turbidites exhibit a wide compositional range, individual examples can be correlated over a wide area and are relatively homogeneous. Organic C oxidation, by bottom water oxygen, proceeds from the turbidite tops downwards after emplacement in pelagic conditions, and the progress of this oxidation front is marked by a sharp colour contrast in the sediments. In turbidites with Csub(org) > 0.5%, redistribution of authigenic U occurs to form a concentration peak (4 to 9 ppm U), just below the oxidation front or colour change. Several tens μg U/cm 2 may be mobilised, and in all examples studied > 60% of the remobilised U is relocated into the peak. Following burial by subsequent turbidites, such U concentration peaks are persistent as relict indicators of their extinct oxidation fronts for at least 2 x 10 5 years. In the case of thin turbidites where labile Csub(org) is almost exhausted, the U peaks may be located in underlying sedimentary units because of their relationship to the oxidation front. A redox mechanism for U peak formation is suggested from these data rather than a complexation with organic matter. (author)

  16. Emplacement hole drill evaluation and specification study. Volume I

    International Nuclear Information System (INIS)

    1977-01-01

    Results of a conceptual design program are presented for mine floor drilling in preparation for radioactive waste disposal. Two classes of drills can be used to drill emplacement holes in salt. Both are sufficiently rugged and reliable. Raise borers have a higher capital cost and require more modifications, but are more flexible in other applications and require less labor. The life cycle cost for the raise borers and for the auger rigs are about the same, while the life cycle costs of bucket drills are much higher. As long as the hole is 36 inches in diameter or less and 40 feet deep or less in salt, then the auger rig is recommended because of the lower capital cost and lower operating cost. This recommended system represents what is thought to be the best combination of available drill components assembled into a drill rig which will provide at least adequate performance. Furthermore, this drill system can be procured from at least three manufacturers. If the facility criteria change significantly, however, then the drill rig recommendations will have to be reassessed on the merits of the changes. The drill rig manufacturers can be quite flexible in combining components provided the buyer is willing to accept components with which the manufacturer has had experience. If this condition can be met, then most drill rig manufacturers will include the associated design cost as part of the drill cost. If special components are required, however, then the number of manufacturers willing to participate in a procurement may be severely reduced

  17. Survival, Fertilization and Developmental Rates of Cryotop-Vitrified Oocyte and Embryo Using Low Concentrated Cryoprotectants

    Directory of Open Access Journals (Sweden)

    A Roozbehi

    2012-10-01

    Full Text Available Background & Aim: The preserving embryos, the risk of multiple pregnancies, the existence of factors in stimulated uterine cycle, are important forces in perfecting embryo cryopreservation. The aim of current study was to assess Survival, Fertilization and Developmental Rates (SRs, FRs, DRs of the mouse oocytes and embryos using cryotop and low concentrated cryoprotectants solutions. Methods: Mouse C57BL/6 oocytes and embryos were collected. Oocytes SRs, FRs, DRs were recorded after cryotop-vitrification/ warming. As well as comparing fresh oocytes and embryos, the data obtained from experimental groups (exp. applying 1.25, 1.0, and 0.75 Molar (M CPAs were analyzed in comparison to those of exp. adopting 1.5 M CPAs (largely-used concentration of EthylenGlycol (EG and Dimethylsulphoxide (DMSO. Results: The data of oocytes exposed to 1.25 M CPAs were in consistency with those exposed to 1.5 M and control group in terms of SR, FR and DR. As fewer concentrations were applied, the more decreased SRs, FRs and DRs were obtained from other experimental groups. The results of embryos were exposed to 1.25 M and 1.0 M was close to those vitrified with 1.5 M and fresh embryos. The results of 0.75 M concentrated CPAs solutions were significantly lower than those of control, 1.5 M and 1.0 M treated groups. Conclusion: CPAs limited reduction to 1.25 M and 1.0 M instead of using 1.5 M, for oocyte and embryo cryotop-vitrification procedure may be a slight adjustment.

  18. NF-PRO research on a repository for vitrified waste and spent fuel

    International Nuclear Information System (INIS)

    Sneyers, A.

    2006-01-01

    NF-PRO is a four-year (2004-2007) Integrated Project supported by funding under the Sixth Research (EURATOM) Programme of the European Commission. NF-PRO is coordinated by SCK C EN and investigates key processes in the near-field of geological repositories for the disposal of high-level vitrified waste and spent nuclear fuel. The near-field of a geological repository consists of the area surrounding the waste packages and is composed of several engineered barriers that enclose and confine the disposed waste. These barriers include the waste form, the waste canisters, backfills, seals, plugs and the part of the host rock that has been modified by the excavation of the repository. In all repository designs under investigation within EU Member States, the near-field plays an important role in ensuring the overall safety of disposal: its principal function is to retain radionuclides over extended periods of time and to minimise their release from the waste to the host rock. The main objective of NF-PRO is to integrate European research on the near field with the aim of enhancing common understanding of the long-term changes taking place in a deep repository. NF-PRO assesses how these changes affect the containment of the disposed radioactive waste. Knowledge generated by the project can be applied in waste management programmes to optimise repository designs and to make barriers functional and resource-efficient. The integration of results from detailed process studies in assessments on the overall near-field system performance is a key objective of NF-PRO. The level of integration envisaged by NF-PRO has not yet been achieved in earlier research projects supported by the European Commission. Accordingly, NF PRO represents a major step forward in the establishing of the scientific and technical basis for geological disposal and the safe management of radioactive wastes

  19. Advanced separation and transmutation, long dated behavior of vitrified wastes: 15 years of scientific researches; Separation poussee et transmutation, comportement a long terme des dechets vitrifies: 15 ans d'avancees scientifiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-02-15

    This report presents the results after 15 years of researches at the Cea, concerning the separation and transmutation of radioactive wastes and the conditioning and the long time storage of wastes at the surface. These researches were asked in the framework of the Bataille law. The first part devoted to the transmutation and separation of ling life radioactive elements presents the challenges, the advanced separation, the transmutation and the evaluation of the researches. The second part devoted to the long dated storage discusses the high activity wastes vitrification, the behavior of the vitrified wastes packages after thousand years, the international researches and the evaluation of the researches. (A.L.B.)

  20. Conceptual designs of automated systems for underground emplacement and retrieval of nuclear waste

    International Nuclear Information System (INIS)

    Slocum, A.H.; Hou, W.M.; Park, K.; Hochmuth, C.; Thurston, D.C.

    1987-01-01

    Current designs of underground nuclear waste repositories have not adequately addressed the possibility of automated, unmanned emplacement and retrieval. This report will present design methodologies for development of an automated system for underground emplacement of nuclear waste. By scaling generic issues to different repositories, it is shown that a two vehicle automated waste emplacement/retrieval system can be designed to operate in a fail-safe mode. Evaluation of cost at this time is not possible. Significant gains in worker safety, however, can be realized by minimizing the possibility of human exposure

  1. Pumping and leak detection system of the HL-2A

    International Nuclear Information System (INIS)

    Cao Zeng; Xu Yunxian; Fu Weidong

    2001-01-01

    The pumping system is a combination of 8 turbomolecular pumps with three stages pumping for HL-2A vacuum vessel, a total effective pumping speed at the vessel of 12 m 3 ·s -1 for nitrogen. The leak detection of element and vessel is performed with inspiration, case of leak detection and two mass spectrometry. The total leak rate of vessel is bellow 1 x 10 -5 Pa ·m 3 ·s -1 . The base pressure is 1 x 10 -5 Pa

  2. Effect of recycling in the HL-1M tokamak

    International Nuclear Information System (INIS)

    Zheng Yongzhen

    2004-01-01

    Tokamak plasma discharge disruption at high density is investigated. The instability analysis on model indicates that the disruption is resulted from the energy loss arising from hydrogen recycling on the edge of the plasma. This energy loss could lead to a contraction of the current channel and the production of a disruptively unstable configuration. Using a simple model we shall investigate the implications of recycling for disruptions. The critical high-density n≤1.6 x 10 20 m -3 is reached in HL-1M. (author)

  3. Intelligent plasma operation and control system for HL-2M

    International Nuclear Information System (INIS)

    Xia, F.; Chen, L.Y.; Wang, C.; Zhang, G.; Song, X.M.; Song, X.; Pan, L.; Zhao, L.; Pan, W.; Lan, J.T.

    2015-01-01

    Full text of publication follows. The Intelligent Plasma Operation and Control System (IPOCS) for HL-2M is under construction based on the current actual situation of HL-2A control system in SWIP. The purpose of IPOCS is to replace the routine processes before, during and post discharge with the automatic process algorithms and give various information, for example, status, warning, reason, instruction, suggestion, physics phenomenon etc. to staff who can access the intranet. In this case, the core research objectives can be focused on and the related operations can be carried out referring to the information. The ultimate goal of IPOCS is to improve the efficiency of plant operation and control and physics research for HL-2M and for the fusion reactor in the future. There are three layers in IPOCS, which are named the information collection layer, the data processing layer and the presentation layer respectively. Information collection layer consists of data acquisition system, EPICS system, Audio and Video system, discharge scheduling system, data storage system etc. All raw data are collected and stored in this layer. The data processing layer is the core of IPOCS. Most algorithms are executed here. The basic computation platform is based on cluster (56 cores at present) and Parallel Computing Toolbox provided by Matlab. The physics database for SWIP based on HDF5 and offline EFIT also locate at this layer. All the operations can be finished during the time interval between two shots. The last layer is to present the information from the former two layers. The typical hardware including the large display screen system in the control room, the voice broadcasting system, personal monitors and smart phones, etc.. Several applications has being developed such as Control System Studio (CSS) in SWIP version, WebOPI, Automatic Alarm Display system and so on. IPOCS for HL-2M is at the very beginning phase at present. With more and more systems and algorithms got

  4. Collimator Layouts for HL-LHC in the Experimental Insertions

    CERN Document Server

    Bruce, R; Esposito, Luigi Salvatore; Jowett, John; Lechner, Anton; Quaranta, Elena; Redaelli, Stefano; Schaumann, Michaela; Skordis, Eleftherios; Eleanor Steele, G; Garcia Morales, H; Kwee-Hinzmann, Regina

    2015-01-01

    This paper presents the layout of collimators for HL-LHC in the experimental insertions. On the incoming beam, we propose to install additional tertiary collimators to protect potential new aperture bottlenecks in cells 4 and 5, which in addition reduce the experimental background. For the outgoing beam, the layout of the present LHC with three physics debris absorbers gives sufficient protection for highluminosity proton operation. However, collisional processes for heavy ions cause localized beam losses with the potential to quench magnets. To alleviate these losses, an installation of dispersion suppressor collimators is proposed.

  5. Integrated simulation tools for collimation cleaning in HL-LHC

    CERN Document Server

    Bruce, R; Cerutti, F; Ferrari, A; Lechner, A; Marsili, A; Mirarchi, D; Ortega, P G; Redaelli, S; Rossi, A; Salvachua, B; Sinuela, D P; Tambasco, C; Vlachoudis, V; Mereghetti, A; Assmann, R; Lari, L; Gibson, S M; Nevay, LJ; Appleby, R B; Molson, J; Serluca, M; Barlow, R J; Rafique, H; Toader, A

    2014-01-01

    The Large Hadron Collider is designed to accommodate an unprecedented stored beam energy of 362 MJ in the nominal configuration and about the double in the high-luminosity upgrade HL-LHC that is presently under study. This requires an efficient collimation system to protect the superconducting magnets from quenches. During the design, it is therefore very important to accurately predict the expected beam loss distributions and cleaning efficiency. For this purpose, there are several ongoing efforts in improving the existing simulation tools or developing new ones. This paper gives a brief overview and status of the different available codes.

  6. New Physics at HL-LHC with ATLAS

    CERN Document Server

    Rosten, Rachel; The ATLAS collaboration

    2018-01-01

    The prospects for new physics at the luminosity upgrade of LHC, HL-LHC, with a data set equivalent to 3000 fb-1, simulated in the upgrade ATLAS detector, are presented and discussed. Benchmark studies are presented to show how the sensitivity improves at the future high-luminosity LHC runs. Prospects for searches for new heavy bosons and dark matter candidates at 14 TeV pp collisions are explored, as well as the sensitivity of searches for anomalous top decays. For all these studies, a parameterised simulation of the upgraded ATLAS detector response is used, taking into account the expected pileup conditions.

  7. Heavy-ion operation of HL-LHC

    CERN Document Server

    Jowett, J M; Versteegen, R

    2015-01-01

    The heavy-ion physics programme of the LHC will continue during the HL-LHC period with upgraded detectors capable of exploiting several times the design luminosity for nucleus–nucleus (Pb–Pb) collisions. For proton–nucleus (p–Pb) collisions, unforeseen in the original design of the LHC, a comparable increase beyond the 2013 luminosity should be attainable. We present performance projections and describe the operational strategies and relatively modest upgrades to the collider hardware that will be needed to achieve these very significant extensions to the physics potential of the High Luminosity LHC.

  8. B-physics studies for HL-LHC ATLAS upgrade

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00236452; The ATLAS collaboration

    2017-01-01

    Performance studies are made to estimate the ATLAS potential in $B$-physics after upgrade for Run2 and HL-LHC. Real data as well as Monte Carlo simulations are used to study the decay of $B^0_s \\to J/\\psi\\phi$ in order to measure the $CP$ violating mixing phase and the width difference between the $B^0_s$ eigenstates. The increased sensitivity is expected mainly due to the improved decay time resolution obtained with the upgraded IBL and ITk inner tracking detector.

  9. The preliminary studies of HL-1 plasma with pump limiter

    International Nuclear Information System (INIS)

    Ran, L.B.; Li, G.D.; Sum, S.Q.

    1991-01-01

    Reduction of the impurity and control of the density are very important task in the present tokamak research. Some experiments showed that the pump limiter is effective to improve impurity and density control. A small-scale pump limiter has been installed on HL-1 tokamak in 1990 and the experiment has been carried out firstly with hydrogen ohmic discharge. In this paper we would present the improvements of the plasma properties as the pump limiter was main limiter and the movable limiter was auxiliary limiter. (author) 3 refs., 8 figs

  10. Investigation on HL-1M pellet shape and cloud structure

    International Nuclear Information System (INIS)

    Zheng Yinjia

    2001-01-01

    When hydrogen multi-pellet flied out from the gun exit and was injected into the HL-1M plasma, the pellet injection and ablation cloud were observed by using a 2D CCD camera SensiCam 360LF. The shape of flight pellet from the gun exit was obtained with the photos taken. The pellet ablation process and the structure of its cloud were analyzed by means of photos with multiple exposure (exp. 100 ns) and long exposure. The experimental setup is described, the results of the pellet injection experiment and characteristic of ablation cloud are presented

  11. Conceptual design of HL-2M tokamak control system

    International Nuclear Information System (INIS)

    Xia Fan; Chen Liaoyuan; Song Xianming; Zhang Jinhua; Lou Cuiwen; Pan Yudong

    2009-01-01

    The static architecture, dynamic behavior, control theory and simulation of HL-2M tokamak control system are described. The real-time network will be build for the communication of real-time control among its subsystems and universal timing system will be build to guarantee the synchronization among the subsystems. The duty to achieve preprogrammed parameters is carried out by plasma discharge control. In order to reduce the damage made by discharge exception, the error-handing mechanism of supervision system is considered. The controllers of magnetic control system are designed to control the current, shape and position of plasma and simulation system is designed for testing the controllers. (authors)

  12. Formation of alteration products during dissolution of vitrified ILW in a high-pH calcium-rich solution

    Energy Technology Data Exchange (ETDEWEB)

    Utton, C.A., E-mail: c.utton@sheffield.ac.uk [Immobilisation Science Laboratory, Department of Materials Science and Engineering, University of Sheffield, Sir Robert Hadfield Building, Mappin Street, Sheffield S1 3JD (United Kingdom); Hand, R.J.; Hyatt, N.C. [Immobilisation Science Laboratory, Department of Materials Science and Engineering, University of Sheffield, Sir Robert Hadfield Building, Mappin Street, Sheffield S1 3JD (United Kingdom); Swanton, S.W. [AMEC, B150, Thomson Avenue, Harwell Oxford, Didcot, Oxfordshire OX11 0QB (United Kingdom); Williams, S.J. [Nuclear Decommissioning Authority, NDA Harwell Office, Building 587, Curie Avenue, Harwell Oxford, Didcot OX11 0RH (United Kingdom)

    2013-11-15

    To simulate the possible disposition of a vitrified intermediate-level waste (ILW) in a cementitious environment within a geological disposal facility (GDF), the durability of a laboratory simulant ILW vitrified in a borosilicate glass in a saturated Ca(OH){sub 2} solution (pH ∼12.5) was measured. Both a low surface area to volume (SA/V) ratio (∼10 m{sup −1}) Materials Characterisation Center test 1 (MCC-1) and a high SA/V ratio (∼10,000 m{sup −1}) product consistency test type B (PCT-B) were used at 50 °C for up to 170 days. The formation of alteration layers and products was followed. The surfaces of the monoliths were analysed using SEM/EDX and showed the formation of magnesium-rich precipitates and distinct calcium silicate hydrate (CSH) precipitates. Cross sections showed the development of a calcium-rich alteration layer, which was observed from 14 days. The altered layer was up to 5 μm thick after 170 days and showed accumulation of zirconium, iron and magnesium and to a lesser extent aluminium, along with calcium and silicon. Based on comparison of the rate data, it is suggested that the presence of this layer may offer some protection to the underlying glass. However, the high SA/V ratio experiments showed resumed alteration after 56 days, indicating that the altered layer may not be protective in the long term (under accelerated conditions). The formation of a magnesium-containing smectite clay (likely saponite) in addition to CSH(II), a jennite-like CSH phase, were identified in the high SA/V experiment by X-ray diffraction after 170 days. These results suggest that calcium and magnesium have important roles in both the long and shorter-term durability of vitrified wastes exposed to high pH.

  13. Cosmetic micromanipulation of vitrified-warmed cleavage stage embryos does not improve ART outcomes: An ultrastructural study of fragments.

    Science.gov (United States)

    Safari, Somayyeh; Khalili, Mohammad Ali; Barekati, Zeinab; Halvaei, Iman; Anvari, Morteza; Nottola, Stefania A

    2017-09-01

    The aim was to study the ultrastructure of cytoplasmic fragments along with the effect of cosmetic micromanipulation (CM) on the morphology and development of vitrified-warmed embryos as well as assisted reproductive technology (ART) outcomes. A total of 96 frozen embryo transfer (FET) cycles were included in this prospective randomized study. They were divided into three groups of CM (n=32), sham (n=32) and control (n=32). In the CM group, the vitrified- warmed embryos were subjected to fragments and coarse granules removal (cosmetic micromanipulation) after laser assisted zona hatching (LAH); sham group subjected only to LAH and no intervention was taken for the control group. Fragmented embryo was evaluated by transmission electron microscopy (TEM). Significant improvement was observed in the morphological parameters, such as fragmentation degrees, evenness of the blastomeres and embryo grade during the subsequent development, after applying cosmetic micromanipulation, when compared to sham or control groups (P=0.00001). However, there were no differences in the clinical outcomes amongst the three studied groups e.g. the rates of clinical, ongoing and multiple pregnancies, implantation, delivery and live birth. In fine structure view, fragments exhibited uniform cytoplasmic texture containing majority of organelles that were observed in normal blastomeres including mitochondria. In conclusion, application of cosmetic micromanipulation in low-grade vitrified-warmed embryos showed significant improvement on embryo morphology parameters; however, did not result in noticeable improvements in clinical outcomes of the patients undergoing ART program. In addition, embryo vitrification had no adverse effects on fine structure of the fragments. Copyright © 2017 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  14. Calculation of drift seepage for alternative emplacement designs

    International Nuclear Information System (INIS)

    Li, Guomin; Tsang, Chin-Fu; Birkholzer, Jens

    1999-01-01

    The calculations presented in this report are performed to obtain seepage rates into drift and boreholes for two alternative designs of drift and waste emplacement at Yucca Mountain. The two designs are defined according to the Scope of Work 14012021M1, activity 399621, drafted October 6, 1998, and further refined in a conference telephone call on October 13, 1998, between Mark Balady, Jim Blink, Rob Howard and Chin-Fu Tsang. The 2 designs considered are: (1) Design A--Horizontal boreholes 1.0 m in diameter on both sides of the drift, with each borehole 8 m long and inclined to the drift axis by 30 degrees. The pillar between boreholes, measured parallel to the drift axis, is 3.3 m. In the current calculations, a simplified model of an isolated horizontal borehole 8 m long will be simulated. The horizontal borehole will be located in a heterogeneous fracture continuum representing the repository layer. Three different realizations will be taken from the heterogeneous field, representing three different locations in the rock. Seepage for each realization is calculated as a function of the percolation flux. Design B--Vertical boreholes, 1.0 m in diameter and 8.0 m deep, drilled from the bottom of an excavated 8.0 m diameter drift. Again, the drift with the vertical borehole will be assumed to be located in a heterogeneous fracture continuum, representing the rock at the repository horizon. Two realizations are considered, and seepage is calculated for the 8-m drift with and without the vertical 1-m borehole at its bottom

  15. Comments on a paper tilted 'The sea transport of vitrified high-level radioactive wastes: Unresolved safety issues'

    International Nuclear Information System (INIS)

    Sprung, J.L.; McConnell, P.E.; Nigrey, P.J.; Ammerman, D.J.

    1997-05-01

    The cited paper estimates the consequences that might occur should a purpose-built ship transporting Vitrified High Level Waste (VHLW) be involved in a severe collision that causes the VHLW canisters in one Type-B package to spill onto the floor of a major ocean fishing region. Release of radioactivity from VHLW glass logs, failure of elastomer cask seals, failure of VHLW canisters due to stress corrosion cracking (SCC), and the probabilities of the hypothesized accident scenario, of catastrophic cask failure, and of cask recovery from the sea are all discussed

  16. Evaluation of the safety of vitrified high level waste shipments from UK to continental Europe by sea

    International Nuclear Information System (INIS)

    Lange, F.; Fett, H.; Hormann, E.; Rowekamp, M.; Elston, B.; Slawson, G.; Cheshire, R.; Schneider, T.; Raffestin, D.

    1998-10-01

    This document, prepared in the framework of a study for the European Commission in collaboration with the GRS (Germany and BNFL (United Kingdom), relates to the evaluation of the safety associated to the maritime transport of vitrified wastes from the United Kingdom towards Europe. With this intention, a travel of 1000 nautical miles (1852 km) was considered and a detailed analysis of the boat used by BNFL has been realized in order to elaborate a fault tree, for scenarios able to generate mechanical and thermal stresses significant on the transport packages (type B-packages). (A.L.B.)

  17. A Review and Analysis of European Industrial Experience in Handling LWR Spent Fuel and Vitrified High-Level Waste

    Energy Technology Data Exchange (ETDEWEB)

    Blomeke, J.O.

    2001-07-10

    The industrial facilities that have been built or are under construction in France, the United Kingdom, Sweden, and West Germany to handle light-water reactor (LWR) spent fuel and canisters of vitrified high-level waste before ultimate disposal are described and illustrated with drawings and photographs. Published information on the operating performance of these facilities is also given. This information was assembled for consideration in planning and design of similar equipment and facilities needed for the Federal Waste Management System in the United States.

  18. Parameters and criteria influencing the selection of waste emplacement configurations in mined geologic repositories

    International Nuclear Information System (INIS)

    Bechthold, W.; Closs, K.D.; Papp, R.

    1988-01-01

    Reference concepts for repositories in deep geological formations have been developed in several countries. For these concepts, emplacement configurations vary within a wide range that comprises drift emplacement of unshielded or self-shielded packages and horizontal or vertical borehole emplacement. This is caused by different parameters, criteria, and criteria weighting factors. Examples for parameters are the country's nuclear power program and waste management policy, its geological situation, and safety requirements, examples for criteria and repository area requirements, expenditures of mining and drilling, and efforts for emplacement and, if required, retrieval. Due to the variety of these factors and their ranking in different countries, requirements for a safe, dependable and cost-effective disposal of radioactive waste can be met in various ways

  19. Thermal/thermomechanical analyses for the room region with horizontal and vertial modes of emplacement

    International Nuclear Information System (INIS)

    1988-01-01

    Extensive thermal/thermomechanical analyses of the Site Characterization Plan-Conceptual Design at the Deaf Smith county Site, Texas, have been carried out for the room region with horizontal and vertical modes of emplacement. The main purpose of this study is to make a good comparison between these two modes of emplacement in this region. Homogeneous and nonhomogeneous strata under isothermal or transient temperature conditions cases were considered in the analyses. Furthermore, various pillar widths for the vertical mode emplacement were also taken into consideration. Only spent fuel (SF) waste was considered in this study. Finite element method was used throughout the analyses. The thermal responses were evaluated using SPECTROM-41 while the thermomechanical responses were calculated using SPECTROM-32. Thermal and thermomechanical comparisons between the two modes of emplacement for various cases were presented in this paper

  20. GRAIN SIZE CONSTRAINTS ON HL TAU WITH POLARIZATION SIGNATURE

    Energy Technology Data Exchange (ETDEWEB)

    Kataoka, Akimasa; Dullemond, Cornelis P [Zentrum für Astronomie der Universität Heidelberg, Institut für Theoretische Astrophysik, Albert-Ueberle-Str. 2, D-69120 Heidelberg (Germany); Muto, Takayuki [Division of Liberal Arts, Kogakuin University, 1-24-2 Nishi-Shinjuku, Shinjuku-ku, Tokyo 163-8677 (Japan); Momose, Munetake; Tsukagoshi, Takashi, E-mail: kataoka@uni-heidelberg.de [College of Science, Ibaraki University, 2-1-1 Bunkyo, Mito, Ibaraki 310-8512 (Japan)

    2016-03-20

    The millimeter-wave polarization of the protoplanetary disk around HL Tau has been interpreted as the emission from elongated dust grains aligned with the magnetic field in the disk. However, the self-scattering of thermal dust emission may also explain the observed millimeter-wave polarization. In this paper, we report a modeling of the millimeter-wave polarization of the HL Tau disk with the self-polarization. Dust grains are assumed to be spherical and to have a power-law size distribution. We change the maximum grain size with a fixed dust composition in a fixed disk model to find the grain size to reproduce the observed signature. We find that the direction of the polarization vectors and the polarization degree can be explained with the self-scattering. Moreover, the polarization degree can be explained only if the maximum grain size is ∼150 μm. The obtained grain size from the polarization is different from that which has been previously expected from the spectral index of the dust opacity coefficient (a millimeter or larger) if the emission is optically thin. We discuss that porous dust aggregates may solve the inconsistency of the maximum grain size between the two constraints.

  1. The synthesis of phosphatidylalcohols in HL-60 cells

    International Nuclear Information System (INIS)

    Tettenborn, C.S.

    1988-01-01

    This study focuses upon the phenomenon that 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulates a pathway for the synthesis of phosphatidylalcohols in HL-60 cells during the differentiation of these cells to macrophages. Using exogenous ethanol as a substrate for this pathway, the synthesis of phosphatidylethanol is induced by TPA well before full expression of differentiation. Experiments done in whole cell cultures demonstrated that this pathway could utilize a wide range of other alcohols as substrates, including glycerol, a potential endogenous substrate. Using radiolabeling and iodine-staining as criteria, this TPA-inducible pathway was shown to result in a dramatic alteration of phospholipid composition, depending on the availability of the alcohol headgroup. A cell-free system was developed to explore the enzymatic reactions involved in phosphatidylalcohol synthesis, a main goal of these studies. For this purpose, the lipid pools of HL-60 cells were prelabeled with [ 3 H]arachidonic acid in the absence of ethanol and total cell homogenates were prepared by sonication. The ability of the cell lysates to synthesize phosphatidylethanol was assayed after addition of ethanol to the system

  2. Instrumentation for silicon tracking at the HL-LHC

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00524651; Strandberg, Sara; Garcia-Sciveres, Maurice

    2017-06-14

    In 2027 the Large Hadron Collider (LHC) at CERN will enter a high luminosity phase, deliver- ing 3000 fb 1 over the course of ten years. The High Luminosity LHC (HL-LHC) will increase the instantaneous luminosity delivered by a factor of 5 compared to the current operation pe- riod. This will impose significant technical challenges on all aspects of the ATLAS detector but particularly the Inner Detector, trigger, and data acquisition systems. In addition, many of the components of the Inner Detector are reaching the end of their designed lifetime and will need to be exchanged. As such, the Inner Detector will be entirely replaced by an all silicon tracker, known as the Inner Tracker (ITk). The layout of the Pixel and strip detectors will be optimised for the upgrade and will extend their forward coverage. To reduce the per-pixel hit rate and explore novel techniques for deal- ing with the conditions in HL-LHC, an inter-experiment collaboration called RD53 has been formed. RD53 is tasked with producing a front...

  3. GRAIN SIZE CONSTRAINTS ON HL TAU WITH POLARIZATION SIGNATURE

    International Nuclear Information System (INIS)

    Kataoka, Akimasa; Dullemond, Cornelis P; Muto, Takayuki; Momose, Munetake; Tsukagoshi, Takashi

    2016-01-01

    The millimeter-wave polarization of the protoplanetary disk around HL Tau has been interpreted as the emission from elongated dust grains aligned with the magnetic field in the disk. However, the self-scattering of thermal dust emission may also explain the observed millimeter-wave polarization. In this paper, we report a modeling of the millimeter-wave polarization of the HL Tau disk with the self-polarization. Dust grains are assumed to be spherical and to have a power-law size distribution. We change the maximum grain size with a fixed dust composition in a fixed disk model to find the grain size to reproduce the observed signature. We find that the direction of the polarization vectors and the polarization degree can be explained with the self-scattering. Moreover, the polarization degree can be explained only if the maximum grain size is ∼150 μm. The obtained grain size from the polarization is different from that which has been previously expected from the spectral index of the dust opacity coefficient (a millimeter or larger) if the emission is optically thin. We discuss that porous dust aggregates may solve the inconsistency of the maximum grain size between the two constraints

  4. Fast reciprocating probe system on the HL-2A tokamak

    International Nuclear Information System (INIS)

    Yan Longwen; Hong Wenyu; Qian Jun; Luo Cuiwen; Pan Li

    2005-01-01

    A reciprocating probe system has been installed at the midplane of the HL-2A tokamak. The probe is used to measure plasma edge density, temperature, floating potential, and corresponding fluctuation profiles with 8 cm scan from the scrape-off layer to the plasma boundary. The reciprocating probe can move at a speed of 1 m/s. A digital grating displacement measurement system that can provide a high displacement resolution of 0.04 mm is applied to the reciprocating probe system for the first time. A port located behind the vacuum isolation valve is designed for viewing and the exchange of the probe head. Different probe heads can be used to satisfy different experimental requirements. The first probe head had four graphite measurement tips. For high frequency response, no isolation amplifier is used in the electric circuit of the probe measurement. A personal computer via an analog-to-digital digitizer card acquires probe system data, which are sent to a data server by optical fiber after a discharge. All data are sent to the centralized data management system of the HL-2A. In this article we presented the edge temperature and density profiles for the limiter and divertor configurations of a selected plasma discharge

  5. Upgrades of the CMS Outer Tracker for HL-LHC

    CERN Document Server

    AUTHOR|(CDS)2067159

    2016-01-01

    The LHC machine is planning an upgrade program which will smoothly bring the luminosity to about 5×1034cm$^{−2}$s$^{−1}$ around 2028, to possibly reach an integrated luminosity of 3000 fb$^{−1}$ in the following decade. This High Luminosity LHC scenario, HL-LHC, will require a preparation program of the LHC detectors known as Phase-2 upgrade. The current CMS Outer Tracker, already running close to its design limits, will not be able to survive HL-LHC radiation conditions and CMS will need a completely new device, in order to fully exploit the highly demanding operating conditions and the delivered luminosity. The new Tracker should have also L1 trigger capabilities. To achieve such goals, R&D; activities are ongoing to explore options and develop solutions that would allow including tracking information at Level-1. The design choices for the CMS Outer Tracker upgrades are discussed along with some highlights of the R&D; activities.

  6. The ATLAS tracker strip detector for HL-LHC

    CERN Document Server

    Cormier, Kyle James Read; The ATLAS collaboration

    2016-01-01

    As part of the ATLAS upgrades for the High Luminsotiy LHC (HL-LHC) the current ATLAS Inner Detector (ID) will be replaced by a new Inner Tracker (ITk). The ITk will consist of two main components: semi-conductor pixels at the innermost radii, and silicon strips covering larger radii out as far as the ATLAS solenoid magnet including the volume currently occupied by the ATLAS Transition Radiation Tracker (TRT). The primary challenges faced by the ITk are the higher planned read out rate of ATLAS, the high density of charged particles in HL-LHC conditions for which tracks need to be resolved, and the corresponding high radiation doses that the detector and electronics will receive. The ITk strips community is currently working on designing and testing all aspects of the sensors, readout, mechanics, cooling and integration to meet these goals and a Technical Design Report is being prepared. This talk is an overview of the strip detector component of the ITk, highlighting the current status and the road ahead.

  7. The ATLAS tracker strip detector for HL-LHC

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00512833; The ATLAS collaboration

    2017-01-01

    As part of the ATLAS upgrades for the High Luminsotiy LHC (HL-LHC) the current ATLAS Inner Detector (ID) will be replaced by a new Inner Tracker (ITk). The ITk will consist of two main components: semi-conductor pixels at the innermost radii, and silicon strips covering larger radii out as far as the ATLAS solenoid magnet including the volume currently occupied by the ATLAS Transition Radiation Tracker (TRT). The primary challenges faced by the ITk are the higher planned read out rate of ATLAS, the high density of charged particles in HL-LHC conditions for which tracks need to be resolved, and the corresponding high radiation doses that the detector and electronics will receive. The ITk strips community is currently working on designing and testing all aspects of the sensors, readout, mechanics, cooling and integration to meet these goals and a Technical Design Report is being prepared. This talk is an overview of the strip detector component of the ITk, highlighting the current status and the road ahead.

  8. The CMS Tracker upgrade for HL-LHC

    CERN Document Server

    Ahuja, Sudha

    2017-01-01

    The LHC machine is planning an upgrade program which will smoothly bring the luminosity to about 5 $\\times$ $10^{34} $cm$^{-2}$s$^{-1}$ in 2028, to possibly reach an integrated luminosity of 3000 fb$^{-1}$ by the end of 2037. This High Luminosity LHC scenario, HL-LHC, will require a preparation program of the LHC detectors known as Phase-2 upgrade. The current CMS Outer Tracker, already running beyond design specifications, and CMS Phase1 Pixel Detector will not be able to survive HL-LHC radiation conditions and CMS will need completely new devices, in order to fully exploit the high-demanding operating conditions and the delivered luminosity. The new Outer Tracker should have also trigger capabilities. To achieve such goals, R$\\&$D activities are ongoing to explore options both for the Outer Tracker, and for the pixel Inner Tracker. Solutions are being developed that would allow including tracking information at Level-1. The design choices for the Tracker upgrades are discussed along with some highlights...

  9. Magnetic Frequency Response of HL-LHC Beam Screens

    Energy Technology Data Exchange (ETDEWEB)

    Morrone, M. [CERN; Martino, M. [CERN; De Maria, R. [CERN; Fitterer, M. [Fermilab; Garion, C. [CERN

    2017-10-12

    Magnetic fields used to control particle beams in accelerators are usually controlled by regulating the electrical current of the power converters. In order to minimize lifetime degradation and ultimately luminosity loss in circular colliders, current-noise is a highly critical figure of merit of power converters, in particular for magnets located in areas with high beta-function, like the High Luminosity Large Hadron Collider (HL-LHC) insertions. However, what is directly acting upon the beam is the magnetic field and not the current of the power converter, which undergoes several frequency-dependent transformations until the desired magnetic field, seen by the beam, is obtained. Beam screens are very rarely considered when assessing or specifying the noise figure of merit, but their magnetic frequency response is such that they realize relatively effective low pass filtering of the magnetic field produced by the system magnet-power converter. This work aims at filling this gap by quantifying the expected impact of different beam screen layouts for the most relevant HL-LHC insertion magnets. A welldefined post-processing technique is used to derive the frequency response of the different multipoles from multi-physics Finite Element Method (FEM) simulation results. In addition, a well approximated analytical formula for the low-frequency range of multi-layered beam screens is presented.

  10. Mechanisms Of Saucer-Shaped Sill Emplacement: Insight From Experimental Modeling

    Science.gov (United States)

    Galland, O.; Planke, S.; Malthe-Sørenssen, A.; Polteau, S.; Svensen, H.; Podladchikov, Y. Y.

    2006-12-01

    It has been recently demonstrated that magma intrusions in sedimentary basins had a strong impact on petroleum systems. Most of these intrusions are sills, and especially saucer-shaped sills. These features can be observed in many sedimentary basins (i.e. the Karoo basin, South Africa; the Norwegian and North Sea; the Tunguska basin, Siberia; the Neuquén basin in Argentina). The occurrence of such features in so various settings suggests that their emplacement results from fundamental processes. However, the mechanisms that govern their formation remain poorly constrained. Experiments were conducted to simulate the emplacement of saucer-shaped magma intrusions in sedimentary basins. The model rock and magma were fine-grained silica flour and molten vegetable oil, respectively. This modeling technique allows simultaneous simulation of magma emplacement and brittle deformation at a basin scale. For our purpose, we performed our experiments without external deformation. During the experiments, the oil was injected horizontally at constant flow rate within the silica flour. Then the oil initially emplaced in a sill, whereas the surface of the model inflated into a smooth dome. Subsequently, the oil propagated upwards along inclined sheets, finally reaching the surface at the edge of the dome. The resulting geometries of the intrusions were saucer-shaped sills. Then the oil solidified, and the model was cut in serial cross-sections through which the structures of the intrusive body and of the overburden can be observed. In order to constraint the processes governing the emplacement of such features, we performed a parametric study based on a set of experiments in which we systematically varied parameters such as the depth of emplacement and the injection flow rate of the oil. Our results showed that saucer diameters are larger at deeper level of emplacement. Opposite trend was obtained with varying injection flow rates. Based on our results, we conducted a detailed

  11. Geochemical and petrographic studies and the relationships to durability and leach resistance of vitrified products from the in situ vitrification process

    International Nuclear Information System (INIS)

    Timmons, D.M.; Thompson, L.E.

    1996-01-01

    Soil and sludge contaminated with hazardous and radioactive materials from sites in the United States and Australia were vitrified using in situ vitrification. Some of the resulting products were subjected to detailed geochemical, leach and durability testing using a variety of analytical techniques. The leach resistance and durability performance was compared to that of vitrified high level waste with borosilicate composition. Particular attention was given to crystallization behavior, the effects of crystallization on residual melt chemistry and how crystallization influences the behavior of contaminant ions. The results of this work show that the vitrified material studied has superior chemical durability and leach resistance relative to typical borosilicate waste glasses. Crystallization behavior was variable depending upon melt chemistry and cooling history. Crystallization was not observed to adversely affect chemical durability or leach resistance

  12. Birth of normal infants after transfer of embryos that were twice vitrified/warmed at cleavage stages: report of two cases.

    Science.gov (United States)

    Valle, Marcello; Guimarães, Fernando; Cavagnoli, Melissa; Sampaio, Marcos; Geber, Selmo

    2012-12-01

    The role of cryopreservation in assisted reproductive technology programs has increased within the last years allowing the transfer of a limited number of embryos and the storage of the remaining for future use. The reduction in the number of transferred embryos decreases the frequency of multiple pregnancy rates and of ovarian hyperstimulation syndrome while the cumulative pregnancy rate can be maximized. Moreover, as not all embryos will survive the warming process more cleavage stage embryos are warmed to improve selection for transfer. Therefore, surplus good quality cleavage stage embryos and/or blastocysts must be re-vitrified for further transfer to achieve pregnancy. To our knowledge, there have been no reports demonstrating that human embryos can be successfully vitrified/warmed twice at the cleavage stage. Thus we report two successful pregnancies and deliveries of healthy babies after transfer of embryos that were twice vitrified/warmed at 2-4 cells stage. Copyright © 2012 Elsevier Inc. All rights reserved.

  13. [Drug resistance reversal of HL-60/ADR cells by simultaneous suppression of XIAP and MRP].

    Science.gov (United States)

    Wang, Xiao-Fang; Wang, Chun; Qin, You-Wen; Yan, Shi-Ke; Gao, Yan-Rong

    2006-12-01

    This study was purposed to explore the mechanisms of drug resistance of HL-60/ADR cells and to compare the reversal drug-resistance effects of antisense oligonucleotides (AS ODN) of XIAP (X-linked inhibitor of apoptosis protein) and AS ODNs of MRP (multidrug resistance-associated protein) by use alone or in combination. Reverse transcription-PCR and Western blot were applied to detect the expression of XIAP, BCL-2, MRP and MDR1 in mRNA and protein levels of HL-60 cells and HL-60/ADR cells, respectively. Fully phosphorothioated AS ODN of XIAP and MRP was delivered into HL-60/ADR cells with Lipofectamine 2000 in the form of liposome-ODN complexes alone or in combination. CCK-8 cell viability assay was used to determine the effect of AS ODN of XIAP and MRP used alone or in combination on the chemotherapy sensitivity of HL-60/ADR cells to daunorubicin (DNR). Reverse transcription-PCR and Western blot were applied to examine the changes of XIAP, MRP in mRNA and protein levels respectively. The results showed that MRP and XIAP were both significantly higher in HL-60/ADR cells than those in HL-60 cells. AS ODN of XIAP and MRP down-regulated the expression of XIAP and MRP in HL-60/ADR cells and increased the sensitivity of HL-60/ADR cells to DNR, respectively. AS ODN of XIAP + MRP did not enhance the inhibition expression of XIAP in HL-60/ADR cells but increased the sensitivity of HL-60/ADR cells to DNR significantly as compared with AS ODN of XIAP (P MRP did not increase the concentration of DNR nor enhanced the inhibition expression of MRP in HL-60/ADR cells but increased the sensitivity of HL-60/ADR cells to DNR significantly (P MRP. It is concluded that both XIAP and MRP may be involved in the drug resistance mechanisms of HL-60/ADR cells. Drug-resistance of HL-60/ADR cells can be reversed significantly when antisense oligonucleotides of XIAP and MRP were used in combination.

  14. Magnetic properties and emplacement of the Bishop tuff, California

    Science.gov (United States)

    Palmer, H.C.; MacDonald, W.D.; Gromme, C.S.; Ellwood, B.B.

    1996-01-01

    Anisotropy of magnetic susceptibility (AMS) and characteristic remanence were measured for 45 sites in the 0.76 Ma Bishop tuff, eastern California. Thirty-three sites were sampled in three stratigraphic sections, two in Owens gorge south of Long Valley caldera, and the third in the Adobe lobe north of Long Valley. The remaining 12 sites are widely distributed, but of limited stratigraphic extent. Weakly indurated, highly porous to dense, welded ash-flow tuffs were sampled. Saturation magnetization vs temperature experiments indicate two principal iron oxide phases: low Ti magnetites with 525-570 ??C Curie temperatures, and maghemite with 610??-640??C Curie temperatures. AF demagnetization spectra of isothermal remanent magnetizations are indicative of magnetite/maghemite predominantly in the multidomain to pseudo-single domain size ranges. Remeasurement of AMS after application of saturating direct fields indicates that randomly oriented single-domain grains are also present. The degree of anisotropy is only a few percent, typical of tuffs. The AMS ellipsoids are oblate with Kmin axes normal to subhorizontal foliation and Kmax axes regionally aligned with published source vents. For 12 of 16 locality means, Kmax axes plunge sourceward, confirming previous observations regarding flow sense. Topographic control on flow emplacement is indicated by the distribution of tuff deposits and by flow directions inferred from Kmax axes. Deposition east of the Benton range occurred by flow around the south end of the range and through two gaps (Benton notch and Chidago gap). Flow down Mammoth pass of the Sierra Nevada is also evident. At least some of the Adobe lobe in the northeast flowed around the west end of Glass mountain. Eastward flow directions in the upper Owens gorge and southeast directions in the lower Owens gorge are parallel to the present canyon, suggesting that the present drainage has been established along the pre-Bishop paleodrainage. Characteristic remanence

  15. An optimization procedure for borehole emplacement in fractured media

    International Nuclear Information System (INIS)

    Billaux, D.; Guerin, F.

    1998-01-01

    Specifying the position and orientation of the 'next borehole(s)' in a fractured medium, from prior incomplete knowledge of the fracture field and depending on the objectives assigned to this new borehole(s), is a crucial point in the iterative process of site characterization. The work described here explicitly includes site knowledge and specific objectives in a tractable procedure that checks possible borehole characteristics, and rates all trial boreholes according to their compliance with objectives. The procedure is based on the following ideas : Firstly, the optimization problem is strongly constrained, since feasible borehole head locations and borehole dips are generally limited. Secondly, a borehole is an 'access point' to the fracture network. Finally, when performing a flow or tracer test, the information obtained through the monitoring system will be best if this system detects the largest possible share of the flow induced by the test, and if it cuts the most 'interesting' flow paths. The optimization is carried out in four steps. 1) All possible borehole configurations are defined and stored. Typically, several hundred possible boreholes are created. Existing boreholes are also specified. 2) Stochastic fracture networks reproducing known site characteristics are generated. 3) A purely geometrical rating of all boreholes is used to select the 'geometrically best' boreholes or groups of boreholes. 4) Among the boreholes selected by the geometrical rating, the best one(s) is chosen by simulating the experiment for which it will be used and checking flowrates through possible boreholes. This method is applied to study the emplacement of a set of five monitoring boreholes prior to the sinking of a shaft for a planned underground laboratory in a granite massif in France (Vienne site). Twelve geometrical parameters are considered for each possible borehole. A detailed statistical study helps decide on the shape of a minimization function. This is then used

  16. Comparative Noise Performance of Portable Broadband Sensor Emplacements

    Science.gov (United States)

    Sweet, Justin; Arias-Dotson, Eliana; Beaudoin, Bruce; Anderson, Kent

    2015-04-01

    IRIS PASSCAL has supported portable broadband seismic experiments for close to 30 years. During that time we have seen a variety of sensor vaults deployed. The vaults deployed fall into two broad categories, a PASSCAL style vault and a Flexible Array style vault. The PASSCAL vault is constructed of materials available in-county and it is the Principle Investigator (PI) who establishes the actual field deployed design. These vaults generally are a large barrel placed in a ~1 m deep hole. A small pier, decoupled from the barrel, is fashioned in the bottom of the vault (either cement, paving stone or tile) for the sensor placement. The sensor is insulated and protected. Finally the vault is sealed and buried under ~30 cm of soil. The Flexible Array vault is provided to PIs by the EarthScope program, offering a uniform portable vault for these deployments. The vault consists of a 30 cm diameter by 0.75 cm tall piece of plastic sewage pipe buried with ~10 cm of pipe above grade. A rubber membrane covers the bottom and cement was poured into the bottom, coupling the pier to the pipe. The vault is sealed and buried under ~30 cm of soil. Cost, logistics, and the availability of materials in-country are usually the deciding factors for PIs when choosing a vault design and frequently trades are made given available resources. Recently a third type of portable broadband installation, direct burial, is being tested. In this case a sensor designed for shallow, direct burial is installed in a ~20 cm diameter by ~1 m deep posthole. Direct burial installation costs are limited to the time and effort required to dig the posthole and emplace the sensor. Our initial analyses suggest that direct burial sensors perform as well and at times better than sensor in vaults on both horizontal and vertical channels across a range of periods (<1 s to 100 s). Moving towards an instrument pool composed entirely of direct burial sensors (some with integrated digitizers) could yield higher

  17. A concept for a station for the encapsulation of vitrified highly radioactive waste into containers for final disposal

    International Nuclear Information System (INIS)

    Anon

    1984-09-01

    The report presents a concept and plans for a station for the encapsulation of vitrified highly radioactive waste into containers for final disposal. The process steps, the layout of the station, the main components of equipment and the sequence of operations under normal conditions are described. The station is designed for vitrified waste from reprocessing. The volume of the waste packages is 150 l, and each package contains the equivalent of 1.33 tonne HM of fuel. The radionuclide activity of the waste corresponds to spent fuel with a decay time of 40 years from discharge from the reactor. It is assumed that after transport under normal conditions the steel shell enclosing the waste is gastight and its surface is free of contamination. The containers for final disposal are made of cast steel and have the form of hollow cylinders with hemispherical ends; their overall length is 2 m and their overall diameter 0.94 m. The station is so designed that the whole procedure, from supply of the transport containers containing the waste to the delivery of the full final disposal containers, is carried out by remote control behind radiation screens in an area isolated from the environment. Containers that do not fulfill the quality control requirements can be improved or repaired in a special rework cell without interfering with the further normal operation of the plant. (author)

  18. High capacity cask (TN28V) and International Transport System for the return shipment of vitrified high activity wastes

    International Nuclear Information System (INIS)

    Sert, G.; Savornin, B.; Rouquette, Y.

    1989-01-01

    The reprocessing of spent fuel generates different kinds of wastes. Among them fission products and non fissile actinides represent 98% of the radioactivity; these wastes are separated, concentrated, mixed with molten glass and poured into stainless steel containers. For political reasons, it is necessary to return these vitrified high activity wastes to the foreign countries which have decided to have their spent fuel reprocessed in France. So the transport of vitrified waste is vital for both the reprocessor and the utilities that have trusted the reprocessor and this operation has to be securely performed to give satisfaction to all concerned particles. For that reason Cogema will control the whole transport activity from La Hague plants to the receiving facilities of the customers. Therefore cogema will be responsible of the transport whatever the cask type (transport or storage) and will subcontract the transport operation to experienced companies such as Transnucleaire, PNTL or NTL, who will act on behalf of Cogema. Cogema will be the owner of the transport casks while the storage casks will normally be owned by the customers. Both cask types will of course have to comply with the requirements of La Hague, as published by Cogema

  19. Formal methods impact on ANSI standard HL7/IM: filling gaps in MSC theory

    NARCIS (Netherlands)

    W. Wesselink; N. Goga (Nicolae); A.J. Mooij (Arjan); R. Spronk

    2005-01-01

    htmlabstractHealth level seven (HL7) is an ANSI standard that provides a comprehensive framework for electronic health information. The most-widely used HL7 specification is called infrastructure management, which facilitates health-care applications to exchange key sets of clinical and

  20. An experimental study of 99Tcm-HL91 in detection of myocardial viability

    International Nuclear Information System (INIS)

    Xu Tao; Liu Baoping; Meng Yubao; Sun Bingqi; Niu Guangjun; Han Xingmin; Yuan Qiao

    2005-01-01

    Objective: To investigate whether 99 Tc m -4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime (HL91) can be used to distinguish ischemic myocardium segments from infarction segments. Methods: Twenty-five acute myocardial infarction patients (≤6 weeks) and 5 old myocardial infarction patients (> 6 weeks) were included in the study. All the study patients underwent 99 Tc m -HL91 and 99 Tc m -methoxyisobutylisonitrile (MIBI) imaging intervented and unintervented with nitroglycerin, and the myocardium segments were divided into three groups according to 99 Tc m -MIBI imaging results: normal, ischemic, and infarction myocardium segments. The difference of the radial counts of 99 Tc m -HL91 in three groups were analyzed after the imaging with 99 Tc m -HL91. Results: 1) In acute myocardial infarction patients, the accumulation rates of 99 Tc m -HL91 was 95% in normal segment group, 157% in ischemic group, 93% in infarction group. The accumulation rates of 99 Tc m -HL91 in the ischemic group was higher than that in the normal group and infarction group. 2)In old myocardial infarction patients, the accumulation rates of 99 Tc m -HL91 were of no difference among the normal, ischemic, and infarction groups. Conclusion: 99 Tc m -HL91 is a potential marker for detecting the ischemic myocardial tissue. (authors)

  1. The Discharge Design of HL-2M with the Tokamak Simulation Code (TSC)

    International Nuclear Information System (INIS)

    Yudong Pan; Jardin, S.C.; Kes, C.

    2007-01-01

    We present results on the discharge design of the HL-2M tokamak, which is to be an upgrade to the existing HL-2A tokamak. We present simulation results for complete 5-sec. discharges, both double null and lower single null, for both ohmic and auxiliary heated discharges. We also discuss the vertical stability properties of the device

  2. Integration of IEEE 1451 and HL7 exchanging information for patients' sensor data.

    Science.gov (United States)

    Kim, Wooshik; Lim, Suyoung; Ahn, Jinsoo; Nah, Jiyoung; Kim, Namhyun

    2010-12-01

    HL7 (Health Level 7) is a standard developed for exchanging incompatible healthcare information generated from programs or devices among heterogenous medical information systems. At present, HL7 is growing as a global standard. However, the HL7 standard does not support effective methods for treating data from various medical sensors, especially from mobile sensors. As ubiquitous systems are growing, HL7 must communicate with various medical transducers. In the area of sensor fields, IEEE 1451 is a group of standards for controlling transducers and for communicating data from/to various transducers. In this paper, we present the possibility of interoperability between the two standards, i.e., HL7 and IEEE 1451. After we present a method to integrate them and show the preliminary results of this approach.

  3. Expression of caspase-3 gene in apoptotic HL-60 cell and different human tumor cell lines

    International Nuclear Information System (INIS)

    Li Xiaoming; Song Tianbao

    1999-01-01

    Objective: To research the expression of caspase-3 gene in the apoptotic and the control HL-60 cells and in the different human tumor cell lines. Methods: Caspase-3 mRNA in the control and γ-radiation-induced apoptotic HL-60 cells, and in the 6 types of human tumor cell lines, was analysed by Northern blot. Results: The caspase-3 gene transcript was more highly expressed in leukemia cells HL-60, CEM, K562 and neuroblastoma SH-SY5Y than in cervical adenocarcinoma HeLa and breast carcinoma MCF7, and more highly in the radiation-induced apoptotic HL-60 than in the control HL-60 cells. Conclusion: The high level of expression of caspase-3 may aid the efforts to understand the tumor cell sensitivity to radiation, apoptosis and its inherent ability to survive

  4. Performances of Anode-resistive Micromegas for HL-LHC

    Directory of Open Access Journals (Sweden)

    Herlant S.

    2012-06-01

    Full Text Available Micromegas technology is a promising candidate to replace Atlas forward muon chambers -tracking and trigger- for future HL-LHC upgrade of the experiment. The increase on background and pile-up event probability requires detector performances which are currently under studies in intensive RD activities. We studied performances of four different resistive Micromegas detectors with different read-out strip pitches. These chambers were tested using ~120 GeV momentum pions, at H6 CERN-SPS beam line in autumn 2010. For a strip pitch 500μm we measure a resolution of ~90 μm and a efficiency of ~ 98%. The track angle effect on the efficiency was also studied. Our results show that resistive techniques induce no degradation on the efficiency or resolution, with respect to the standard Micromegas. In some configuration the resistive coating is able to reduce the discharge currents at least by a factor of 100.

  5. Investigation of plasma equilibrium in HL-1 tokamak

    International Nuclear Information System (INIS)

    Lu Zhihong; Jiang Yunxia; Yang Jinwei; Zhang Baozhu; Qiu Wei; Qin Yunwen

    1987-01-01

    In this paper, the plasma equilibrium in HL-1 tokamak has been discussed. The horizontal and vertical displacement of plasma is measured using a symmetical magneic probe system, and the temporal evolution of displacements is given by a data acquisition system with micro-computer. The influence of various stray fields on plasma equilibrium has been analysed. The direction and value of horizontal stray field induced by the totoidal field coils and primary windings are determined using vertical displacement data. By adjusting parameters of internal and external vertical field, in the flat part of discharge current, the plasma can be kept in its equilibuium state at the place where is 3 cm outer of chamber certre, i.e nearby the centre of limiter

  6. Will LHCb run in the HL-LHC era?

    International Nuclear Information System (INIS)

    Schmidt, B.

    2012-01-01

    The LHCb collaboration presented a Letter of Intent to the LHCC in March 2011 for upgrading the detector during LS2 (2018) and intends to collect a data sample of 50 fb -1 in the LHC and HL-LHC eras. The physics case and the strategy for the upgrade have been endorsed by the LHCC. This paper presents briefly the physics motivations for the LHCb upgrade and the proposed changes to the detector and trigger. In the following part machine related issues for the LHCb upgrade are discussed, in particular issues in relation to the Target Absorber for Secondaries (TAS), Radiation to Electronics (R2E), β* and crossing angle in IP8. (author)

  7. Magnetic Frequency Response of HL-LHC Beam Screens

    CERN Document Server

    Morrone, M; De Maria, R; Fitterer, M; Garion, C

    2017-01-01

    Magnetic fields used to control particle beams in accelerators are usually controlled by regulating the electrical current of the power converters. In order to minimize lifetime degradation and ultimately luminosity loss in circular colliders, current-noise is a highly critical figure of merit of power converters, in particular for magnets located in areas with high beta-function, like the High Luminosity Large Hadron Collider (HL-LHC) insertions. However, what is directly acting upon the beam is the magnetic field and not the current of the power converter, which undergoes several frequency-dependent transformations until the desired magnetic field, seen by the beam, is obtained. Beam screens are very rarely considered when assessing or specifying the noise figure of merit, but their magnetic frequency response is such that they realize relatively effective low pass filtering of the magnetic field produced by the system magnet-power converter. This work aims at filling this gap by quantifying the expected im...

  8. Silicon strip detectors for the ATLAS HL-LHC upgrade

    CERN Document Server

    Gonzalez Sevilla, S; The ATLAS collaboration

    2011-01-01

    The LHC upgrade is foreseen to increase the ATLAS design luminosity by a factor ten, implying the need to build a new tracker suited to the harsh HL-LHC conditions in terms of particle rates and radiation doses. In order to cope with the increase in pile-up backgrounds at the higher luminosity, an all silicon detector is being designed. To successfully face the increased radiation dose, a new generation of extremely radiation hard silicon detectors is being designed. We give an overview of the ATLAS tracker upgrade project, in particular focusing on the crucial innermost silicon strip layers. Results from a wide range of irradiated silicon detectors for the strip region of the future ATLAS tracker are presented. Layout concepts for lightweight yet mechanically very rigid detector modules with high service integration are shown.

  9. Injection Protection Upgrade for the HL-LHC

    CERN Document Server

    AUTHOR|(CDS)2067108; Biancacci, Nicolo; Bracco, Chiara; Frasciello, Oscar; Gentini, Luca; Goddard, Brennan; Lechner, Anton; Maciariello, Fausto; Perillo Marcone, Antonio; Salvant, Benoit; Shetty, Nikhil Vittal; Steele, Genevieve; Velotti, Francesco; Zobov, Mikhail

    2015-01-01

    The injector complex of the LHC is undergoing important changes in the light of the LIU project to provide brighter beams to the LHC. For this reason and as part of the High Luminosity LHC project the injection protection system of the LHC will be upgraded in the Long Shutdown 2 (2018 - 2019) to be able to protect downstream elements against injection failures with the high brightness, high intensity HL-LHC beams. The upgraded LHC injection protection system will consist of a segmented injection protection absorber TDIS, and auxiliary collimators and masks. The layout modifications are described, and the machine element protection and absorber jaw robustness studies are presented for the new systems.

  10. PLANETARY SYSTEM FORMATION IN THE PROTOPLANETARY DISK AROUND HL TAURI

    Energy Technology Data Exchange (ETDEWEB)

    Akiyama, Eiji; Hasegawa, Yasuhiro; Hayashi, Masahiko; Iguchi, Satoru, E-mail: eiji.akiyama@nao.ac.jp, E-mail: yasuhiro.hasegawa@nao.ac.jp [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan)

    2016-02-20

    We reprocess the Atacama Large Millimeter/Submillimeter Array (ALMA) long-baseline science verification data taken toward HL Tauri. Assuming the observed gaps are opened up by currently forming, unseen bodies, we estimate the mass of such hypothetical bodies based on the following two approaches: the Hill radius analysis and a more elaborate approach developed from the angular momentum transfer analysis in gas disks. For the former, the measured gap widths are used for estimating the mass of the bodies, while for the latter, the measured gap depths are utilized. We show that their masses are comparable to or less than the mass of Jovian planets. By evaluating Toomre’s gravitational instability (GI) condition and cooling effect, we find that the GI might be a mechanism to form the bodies in the outer region of the disk. As the disk might be gravitationally unstable only in the outer region of the disk, inward planetary migration would be needed to construct the current architecture of the observed disk. We estimate the gap-opening mass and show that type II migration might be able to play such a role. Combining GIs with inward migration, we conjecture that all of the observed gaps may be a consequence of bodies that might have originally formed at the outer part of the disk, and have subsequently migrated to the current locations. While ALMA’s unprecedented high spatial resolution observations can revolutionize our picture of planet formation, more dedicated observational and theoretical studies are needed to fully understand the HL Tauri images.

  11. PLANETARY SYSTEM FORMATION IN THE PROTOPLANETARY DISK AROUND HL TAURI

    International Nuclear Information System (INIS)

    Akiyama, Eiji; Hasegawa, Yasuhiro; Hayashi, Masahiko; Iguchi, Satoru

    2016-01-01

    We reprocess the Atacama Large Millimeter/Submillimeter Array (ALMA) long-baseline science verification data taken toward HL Tauri. Assuming the observed gaps are opened up by currently forming, unseen bodies, we estimate the mass of such hypothetical bodies based on the following two approaches: the Hill radius analysis and a more elaborate approach developed from the angular momentum transfer analysis in gas disks. For the former, the measured gap widths are used for estimating the mass of the bodies, while for the latter, the measured gap depths are utilized. We show that their masses are comparable to or less than the mass of Jovian planets. By evaluating Toomre’s gravitational instability (GI) condition and cooling effect, we find that the GI might be a mechanism to form the bodies in the outer region of the disk. As the disk might be gravitationally unstable only in the outer region of the disk, inward planetary migration would be needed to construct the current architecture of the observed disk. We estimate the gap-opening mass and show that type II migration might be able to play such a role. Combining GIs with inward migration, we conjecture that all of the observed gaps may be a consequence of bodies that might have originally formed at the outer part of the disk, and have subsequently migrated to the current locations. While ALMA’s unprecedented high spatial resolution observations can revolutionize our picture of planet formation, more dedicated observational and theoretical studies are needed to fully understand the HL Tauri images

  12. Effect of composition variations on the long-term wasteform behavior of vitrified domestic waste incineration fly-ash purification residues

    International Nuclear Information System (INIS)

    Frugier, Pierre

    1999-01-01

    The effect of variations in the composition of fly-ash purification residue from incinerated domestic waste on the quality of the containment achieved by vitrification was investigated. Three main factors determine the long-term containment quality: the production of a vitrified wasteform, the occurrence of possible crystallization, and the key parameters of long-term alteration in aqueous media. Each of these aspects is described within a composition range defined by variations in the three major elements. (silicon, calcium and aluminum) and two groups of constituents (alkali metals and toxic elements). The silicon fraction in the fly-ash residue was found to be decisive: it is impossible to obtain a satisfactory vitrified wasteform below a given silicon concentration. Compounds with the lowest silica content also exhibited the greatest tendency to crystallize under the cooling conditions prevailing in industrial processes (the dominant crystallized phase is a melilite that occupies a significant fraction of the material and considerably modifies the alteration mechanisms). The initial alteration rate in pure water and the altered glass thickness measured in a closed system at an advanced stage of the dissolution reaction are both inversely related to the silicon concentration in the glass. Several types of long-term behavior were identified according to the composition range, the process conditions and the vitrified waste disposal scenario. Four distinct 'classes' of vitrified wasteform were defined for direct application in industrial processes. (author) [fr

  13. Equipment for the emplacement of heat-producing waste in long horizontal boreholes

    International Nuclear Information System (INIS)

    Young, K.D.; Scully, L.W.; Fisk, A.; deBakker, P.; Friant, J.; Anderson, A.

    1983-01-01

    Emplacement of heat-producing waste in long horizontal holes may offer several technical and economic advantages over shallow vertical hole emplacement. Less of the host rock suffers damage as a result of drift construction; the heat from the waste can be isolated from the access drifts for long periods of time; and the amount of rock which must be excavated is much less than in traditional disposal scenarios. One of the major reasons that has been used to reject the long hole concept in the past and adhere to the shallow vertical hole concept is the equipment required to drill the holes and to emplace and retrieve the waste. Such equipment does not currently exist. It clearly is more difficult to drill a 600 to 1000 foot horizontal hole, possibly 3 to 4 feet in diameter, and place a canister of waste at the end of it than to drill a 30 foot vertical hole and lower the waste to the bottom. A liner, for emplacement hole stabilization, appears to be feasible by adapting existing technology for concrete slip forming or jacking in a steel liner. The conceptual design of the equipment to drill long horizontal holes, emplace waste and retrieve waste will be discussed. Various options in concept will be presented as well as their advantages and disadvantages. The operating scenario of the selected concept will be described as well as solutions to potential problems encountered

  14. Heat transfer effects in vertically emplaced high level nuclear waste container

    International Nuclear Information System (INIS)

    Moujaes, S.F.; Lei, Y.M.

    1994-01-01

    Modeling free convection heat transfer in a cylindrical annular enclosure is still an active area of research and an important problem to be addressed in the high level nuclear waste repository. For the vertically emplaced waste container, the air gap which is between the container shell and the rock borehole, have an important role of dissipating heat to surrounding rock. These waste containers are vertically emplaced in the borehole 300 meters just below ground, and in a horizontal grid of 30 x 8 meters apart. The borehole will be capped after the container emplacement. The expected initial heat generated is between 3-4.74 kW per container depending on the type of waste. The goal of this study is to use a computer simulation model to find the borehole wall, air-gap and the container outer wall temperature distributions. The borehole wall temperature history has been found in the previous study, and was estimated to reach a maximum temperature of about 218 degrees C after 18 years from the emplacement. The temperature history of the rock surface is then used for the air-gap simulation. The problem includes convection and radiation heat transfer in a vertical enclosure. This paper will present the results of the convection in the air-gap over one thousand years after the containers' emplacement. During this long simulation period it was also observed that a multi-cellular air flow pattern can be generated in the air gap

  15. Equipment for the emplacement of heat-producing waste in long horizontal boreholes

    International Nuclear Information System (INIS)

    Young, K.D.; Fisk, A.; Friant, J.; Scully, L.W.

    1983-01-01

    Emplacement of heat-producing waste in long horizontal holes may offer several technical and economic advantages over shallow vertical hole emplacement. Less of the host rock suffers damage as a resul of drift construction; the heat from the waste can be isolated from the access drifts for long periods of time; and the amount of rock which must be excavated is much less than in traditional disposal scenarios. One of the major reasons that has been used to reject the long hole concept in the past and adhere to the shallow vertical hole concept is the equipment required to drill the holes and to emplace and retrieve the waste. Such equipment does not currently exist. It clearly is more difficult to drill a 600 to 100 foot horizontal hole, possibly 3 to 4 feet in diameter, and place a canister of waste at the end of it than to drill a 30 foot vertical hole and lower the waste to the bottom. A liner, for emplacement hole stabilization, appears to be feasible by adapting existing technology for concrete slip forming or jacking in a steel liner. The conceptual design of the equipment to drill long horizontal holes, emplace waste and retrieve waste is discussed. Various options in concept are presented as well as their advantages and disadvantages. The operating scenario of the selected concept is described as well as solutions to potential problems encountered

  16. Reevaluation of Vitrified High-Level Waste Form Criteria for Potential Cost Savings at the Defense Waste Processing Facility - 13598

    Energy Technology Data Exchange (ETDEWEB)

    Ray, J.W. [Savannah River Remediation (United States); Marra, S.L.; Herman, C.C. [Savannah River National Laboratory, Savannah River Site, Aiken, SC 29808 (United States)

    2013-07-01

    At the Savannah River Site (SRS) the Defense Waste Processing Facility (DWPF) has been immobilizing SRS's radioactive high level waste (HLW) sludge into a durable borosilicate glass since 1996. Currently the DWPF has poured over 3,500 canisters, all of which are compliant with the U. S. Department of Energy's (DOE) Waste Acceptance Product Specifications for Vitrified High-Level Waste Forms (WAPS) and therefore ready to be shipped to a federal geologic repository for permanent disposal. Due to DOE petitioning to withdraw the Yucca Mountain License Application (LA) from the Nuclear Regulatory Commission (NRC) in 2010 and thus no clear disposal path for SRS canistered waste forms, there are opportunities for cost savings with future canister production at DWPF and other DOE producer sites by reevaluating high-level waste form requirements and compliance strategies and reducing/eliminating those that will not negatively impact the quality of the canistered waste form. (authors)

  17. Report on the joint USA-Germany drop test program for a vitrified high level waste cask

    International Nuclear Information System (INIS)

    Golliher, K.G.; Witt, C.R.; Wieser, K.E.

    1993-01-01

    A series of full-scale drop tests was performed on a ductile iron transport cask in a cooperative program between the US Department of Energy (DOE) and Bundesantalt fuer Materialpruefung (BAM) in Germany. The tests, which were performed at BAM's test facility located near Lehre, Germany, were performed on a prototype cask designed for transport of Vitrified High Level Waste (VHLW) canisters. The VHLW cask is a right circular cylinder with a diameter of 1156 mm and a height of 3454 cm, and weighs approximately 24.6 kg including its payload of a single VHLW canister. The drop tests were performed with a non-radioactive, prototype VHLW canister in the cavity. (J.P.N.)

  18. Reevaluation Of Vitrified High-Level Waste Form Criteria For Potential Cost Savings At The Defense Waste Processing Facility

    International Nuclear Information System (INIS)

    Ray, J. W.; Marra, S. L.; Herman, C. C.

    2013-01-01

    At the Savannah River Site (SRS) the Defense Waste Processing Facility (DWPF) has been immobilizing SRS's radioactive high level waste (HLW) sludge into a durable borosilicate glass since 1996. Currently the DWPF has poured over 3,500 canisters, all of which are compliant with the U. S. Department of Energy's (DOE) Waste Acceptance Product Specifications for Vitrified High-Level Waste Forms (WAPS) and therefore ready to be shipped to a federal geologic repository for permanent disposal. Due to DOE petitioning to withdraw the Yucca Mountain License Application (LA) from the Nuclear Regulatory Commission (NRC) in 2010 and thus no clear disposal path for SRS canistered waste forms, there are opportunities for cost savings with future canister production at DWPF and other DOE producer sites by reevaluating high-level waste form requirements and compliance strategies and reducing/eliminating those that will not negatively impact the quality of the canistered waste form

  19. Emplacement and retrieval equipment design considerations for a repository in salt

    International Nuclear Information System (INIS)

    Nair, B.R.; Bahorich, R.J.

    1987-01-01

    The current design concept for the disposal of nuclear high level waste packages in a repository in salt is based on the emplacement of individual packages in vertical boreholes in the underground mine floor. A key requirement is that the waste packages be capable of being retrieved during the last 26 years of the 76-year repository operating period. The unique design considerations relating to the retrieval of waste packages emplaced in bedded salt are presented in this paper. The information is based on the experience developed during the design of vertical emplacement and retrieval equipment in support of the Sandia Defense High Level Waste experiments at the Waste Isolation Pilot Plant. Also included are the impact of retrievability on the design of the equipment, the special salt cutting technology that was developed for this application, and a description of the equipment

  20. Waste Handling and Emplacement Options for Disposal of Radioactive Waste in Deep Boreholes.

    Energy Technology Data Exchange (ETDEWEB)

    Cochran, John R.; Hardin, Ernest

    2015-11-01

    Traditional methods cannot be used to handle and emplace radioactive wastes in boreholes up to 16,400 feet (5 km) deep for disposal. This paper describes three systems that can be used for handling and emplacing waste packages in deep borehole: (1) a 2011 reference design that is based on a previous study by Woodward–Clyde in 1983 in which waste packages are assembled into “strings” and lowered using drill pipe; (2) an updated version of the 2011 reference design; and (3) a new concept in which individual waste packages would be lowered to depth using a wireline. Emplacement on coiled tubing was also considered, but not developed in detail. The systems described here are currently designed for U.S. Department of Energy-owned high-level waste (HLW) including the Cesium- 137/Strontium-90 capsules from the Hanford Facility and bulk granular HLW from fuel processing in Idaho.

  1. Heat transfer effects in vertically emplaced high level nuclear waste container

    International Nuclear Information System (INIS)

    Moujaes, S.F.; Lei, Y.M.

    1994-01-01

    Modeling free convection heat transfer in an cylindrical annular enclosure is still an active area of research and an important problem to be addressed in the high level nuclear waste repository. For the vertically emplaced waste container, the air gap which is between the container shell and the rock borehole, have an important role of dissipating heat to surrounding rack. These waste containers are vertically emplaced in the borehole 300 meters below ground, and in a horizontal grid of 30 x 8 meters apart. The borehole will be capped after the container emplacement. The expected initial heat generated is between 3--4.74 kW per container depending on the type of waste. The goal of this study is to use a computer simulation model to find the borehole wall, air-gap and the container outer wall temperature distributions

  2. Waste Handling and Emplacement Options for Disposal of Radioactive Waste in Deep Boreholes

    International Nuclear Information System (INIS)

    Cochran, John R.; Hardin, Ernest

    2015-01-01

    Traditional methods cannot be used to handle and emplace radioactive wastes in boreholes up to 16,400 feet (5 km) deep for disposal. This paper describes three systems that can be used for handling and emplacing waste packages in deep borehole: (1) a 2011 reference design that is based on a previous study by Woodward-Clyde in 1983 in which waste packages are assembled into ''strings'' and lowered using drill pipe; (2) an updated version of the 2011 reference design; and (3) a new concept in which individual waste packages would be lowered to depth using a wireline. Emplacement on coiled tubing was also considered, but not developed in detail. The systems described here are currently designed for U.S. Department of Energy-owned high-level waste (HLW) including the Cesium- 137/Strontium-90 capsules from the Hanford Facility and bulk granular HLW from fuel processing in Idaho.

  3. Migration of gases around a cell containing high-activity vitrified wastes during the operational phase

    International Nuclear Information System (INIS)

    Hoch, A.; Wendling, J.

    2010-01-01

    Document available in extended abstract form only. Andra is studying the Callovo-Oxfordian mud-stones, located at a depth of approximately 500 m beneath the borders of the Meuse and the Haute-Marne Departements, in order to assess the feasibility of constructing a repository for radioactive waste in this low-permeability geological formation. Several categories of waste are being considered for disposal in the geological repository. Of these, the high-activity, long-lived vitrified wastes (known as 'Waste C') are strongly exothermic and will be stored in cells that are about 40 m long, with a single access aperture from an access gallery. The cell wall will be supported by a steel lining. During the reversible operational phase (lasting at least 100 years), and as long as the access galleries are ventilated, the corrosion of the steel lining by oxygen in air will be important. It is necessary to determine the thickness of the lining corroded during this phase in order to be able to design the lining with an appropriate initial thickness to maintain integrity. In addition, at the end of the cell farthest from the ventilated access gallery, it is possible that the oxygen concentration will be so low that corrosion occurs under reducing (anaerobic) conditions. This chemical reaction produces hydrogen gas, which will migrate towards the access gallery. To maintain operational safety, it is necessary to define the hydrogen concentration within the cell and within the access gallery in order to evaluate the fire and/or explosion hazards (the hydrogen-oxygen mixture is highly flammable and/or explosive at certain concentrations). The objectives of this study were to estimate for the reversible operational phase (i.e. for 100 years): - The thickness of the steel lining required to ensure mechanical integrity. - Transfer rates (advection and / or diffusion) and gas concentrations (oxygen, hydrogen and water vapour) at all points in the annular void between the

  4. Preliminary study of energy confinement data with a statistical analysis system in HL-2A tokamak

    International Nuclear Information System (INIS)

    Xu Yuan; Cui Zhengying; Ji Xiaoquan; Dong Chunfeng; Yang Qingwei; O J W F Kardaun

    2010-01-01

    Taking advantage of the HL-2A experimental data,an energy confinement database facing ITERL DB2.0 version has been originally established. As for this database,a world widely used statistical analysis system (SAS) has been adopted for the first time to analyze and evaluate the confinement data from HL-2A and the research on scaling laws of energy confinement time corresponding to plasma density is developed, some preliminary results having been achieved. Finally, through comparing with both ITER scaling law and previous ASDEX database, the investigation about L-mode confinement quality on HL-2A and influence of temperature on Spitzer resistivity will be discussed. (authors)

  5. Isolation of furocoumarins from bergamot fruits as HL-60 differentiation-inducing compounds.

    Science.gov (United States)

    Kawaii, S; Tomono, Y; Katase, E; Ogawa, K; Yano, M

    1999-10-01

    The HL-60 differentiation-inducing compounds in bergamot fruits were isolated with column chromatography and identified as bergamottin, bergapten, and citropten by (1)H and (13)C NMR. Their HL-60 differentiation-inducing activity was measured by examining nitro blue tetrazolium (NBT) reducing, nonspecific acid esterase (NSE), specific esterase (SE), and phagocytic activities, and bergamottin showed the strongest activity among the coumarins isolated from bergamot fruits. The structure-activity relationship obtained from HL-60 differentiation assay suggests that hydrophobicity of furocoumarins is correlated with their activity.

  6. Development of a USB-based multi-channel time division scaler for HL-2A

    International Nuclear Information System (INIS)

    Liang Ping

    2008-01-01

    HL-2A is China's first Tokamak device with divertor configuration. Mastering the process and plasma parameter changes with time are of great significance to achieve controlled nuclear fusion. In the recent upgrading of HL-2A, for which a higher and faster electronic equipment was required, we developed a new type USB multi-channel time division scaler for HL-2A including functions: USB interface, PC graphical user interface, simultaneously calibrating more than five channel signals, optional time division spacing 2-50 ms, count rate up to over 2 MHz, accessing all the information 20 s after a activated signal, and processing data and displaying off-line. (authors)

  7. Eruption and emplacement dynamics of a thick trachytic lava flow of the Sancy volcano (France)

    Science.gov (United States)

    Latutrie, Benjamin; Harris, Andrew; Médard, Etienne; Gurioli, Lucia

    2017-01-01

    A 70-m-thick, 2200-m-long (51 × 106 m3) trachytic lava flow unit underlies the Puy de Cliergue (Mt. Dore, France). Excellent exposure along a 400-m-long and 60- to 85-m-high section allows the flow interior to be accessed on two sides of a glacial valley that cuts through the unit. We completed an integrated morphological, structural, textural, and chemical analysis of the unit to gain insights into eruption and flow processes during emplacement of this thick silicic lava flow, so as to elucidate the chamber and flow dynamic processed that operate during the emplacement of such systems. The unit is characterized by an inverse chemical stratification, where there is primitive lava beneath the evolved lava. The interior is plug dominated with a thin basal shear zone overlying a thick basal breccia, with ramping affecting the entire flow thickness. To understand these characteristics, we propose an eruption model that first involves processes operating in the magma chamber whereby a primitive melt is injected into an evolved magma to create a mixed zone at the chamber base. The eruption triggered by this event first emplaced a trachytic dome, into which banded lava from the chamber base was injected. Subsequent endogenous dome growth led to flow down the shallow slope to the east on which the highly viscous (1012 Pa s) coulée was emplaced. The flow likely moved extremely slowly, being emplaced over a period of 4-10 years in a glacial manner, where a thick (>60-m) plug slid over a thin (5-m-thick) basal shear zone. Excellent exposure means that the Puy de Cliergue complex can be viewed as a case type location for understanding and defining the eruption and emplacement of thick, high-viscosity, silicic lava flow systems.

  8. A feasibility study of the offshore disposal of radioactive waste by drilled emplacement

    International Nuclear Information System (INIS)

    1984-01-01

    This report describes the third phase of a study of the feasibility of disposal and isolation of high level radioactive waste in holes drilled deep into the sediments of the ocean. In this phase, work has concentrated on establishing the logistics of disposing of up to 400 cubic metres of vitrified waste per year, and on the capital and running costs of doing so. The report concludes that the disposal of waste in the form produced by the AVM process is operationally feasible, and that disposal in this way will add approximately 0.2% to the cost of generation of the energy contributing to the waste. (author)

  9. Emplacement time of Salai Patai carbonatite, Malakand, Pakistan, from fission track dating of zircon and apatite

    International Nuclear Information System (INIS)

    Qureshi, A.A.; Khan, H.A.

    1991-01-01

    Based on fission track dating of zircon and apatite, the emplacement history of Salai Patai carbonatite has been traced. It has been estimated that the carbonatite was emplaced along the thrust plane associated with the Indian-Eurasian plate collision during the Oligocene period followed by some thermal/tectonic episode during Early Miocene. This negates the previous proposal that all carbonatites found in Pakistan are a part of a 200 km long alkaline province associated with the rifting of Peshawar Valley during Late Cretaceous or early tertiary. (author)

  10. High level radioactive waste repositories. Task 3. Review of underground handling and emplacement. 1. Executive summary

    Energy Technology Data Exchange (ETDEWEB)

    1981-01-01

    A review is presented of proposals for transport, handling and emplacement of high-level radioactive waste in an underground repository appropriate to the U.K. context, with particular reference to waste block size and configuration; self-shielded or partially-shielded block; stages of disposal; transport by road/rail to repository site; handling techniques within repository; emplacement in vertical holes or horizontal tunnels; repository access by adit, incline or shaft; conventional and radiological safety; costs; and major areas of uncertainty requiring research or development.

  11. Down-regulation of procaspase-8 expression by focal adhesion kinase protects HL-60 cells from TRAIL-induced apoptosis

    International Nuclear Information System (INIS)

    Tamagiku, Yuji; Sonoda, Yoshiko; Kunisawa, Mari; Ichikawa, Daiju; Murakami, Yayoi; Aizu-Yokota, Eriko; Kasahara, Tadashi

    2004-01-01

    We have demonstrated that focal adhesion kinase (FAK)-overexpressed (HL-60/FAK) cells have marked resistance against various apoptotic stimuli such as hydrogen peroxide, etoposide, and ionizing radiation compared with the vector-transfected (HL-60/Vect) cells. HL-60/FAK cells are highly resistant to TRAIL-induced apoptosis, while original HL-60 or HL-60/Vect cells were sensitive. TRAIL at 500 ng/ml induced significant DNA fragmentation, activation of caspase-8 and 3, the processing of a proapoptotic BID, and mitochondrial release of cytochrome c in HL-60/Vect cells, whereas no such events were observed in the HL-60/FAK cells. In particular, the expression of procaspase-8 gene and subsequent cleavage of caspase-8 were markedly reduced in HL-60/FAK cells, while expression of TRAIL-receptor 2 and 3, TRADD, and FADD was equivalent in both types of cells. In HL-60/FAK cells, the phosphoinositide 3 (PI3)-kinase/Akt survival pathway was constitutively activated, accompanied by significant induction of inhibitor-of-apoptosis proteins, XIAP, RIP, and Bcl-XL. The introduction of FAK siRNA in HL-60/FAK cells sensitized them against TRAIL-induced apoptosis, confirming that overexpressed FAK downregulates procaspase-8 expression, which subsequently inhibits downstream apoptosis pathway in the HL-60/FAK cells

  12. The ATLAS computing challenge for HL-LHC

    CERN Document Server

    Campana, Simone; The ATLAS collaboration

    2016-01-01

    The ATLAS experiment successfully commissioned a software and computing infrastructure to support the physics program during LHC Run 2. The next phases of the accelerator upgrade will present new challenges in the offline area. In particular, at High Luminosity LHC (also known as Run 4) the data taking conditions will be very demanding in terms of computing resources: between 5 and 10 KHz of event rate from the HLT to be reconstructed (and possibly further reprocessed) with an average pile-up of up to 200 events per collision and an equivalent number of simulated samples to be produced. The same parameters for the current run are lower by up to an order of magnitude. While processing and storage resources would need to scale accordingly, the funding situation allows one at best to consider a flat budget over the next few years for offline computing needs. In this paper we present a study quantifying the challenge in terms of computing resources for HL-LHC and present ideas about the possible evolution of the ...

  13. Performances of anode-resistive Micromegas for HL-LHC

    International Nuclear Information System (INIS)

    Manjarrés, J; Attié, D; Boyer, M; Derré, J; Ferrer-Ribas, E; Galán, J; Giganon, A; Giomataris, I; Herlant, S; Jeanneau, F; Schune, Ph; Titov, M; Alexopoulos, T; Gazis, E; Tsipolitis, G; Fanourakis, G; Geralis, T

    2012-01-01

    Micromegas technology is a promising candidate to replace Atlas forward muon chambers -tracking and trigger- for future HL-LHC upgrade of the experiment. The LHC accelerator luminosity will be ten times the nominal one, increasing background and pile-up event probability in the same proportion. This requires detector performances which are currently under studies in intensive RD activities. We studied performances of four different resistive Micromegas detectors and with different read-out strip pitches. These chambers were tested using ∼ 120 GeV momentum pions with rates from 25 up to 250 kHz/cm 2 , at H6 CERN-SPS beam line in autumn 2010. We found that the resolution is degraded, if the strip pitch is too wide with respect to the charge distribution at the readout plane. To reduce the systematic effects of the charge sharing we propose a cluster reconstruction algorithm. For narrow strip pitch 500μm we measure a resolution of ∼ 90 μm and a efficiency of ∼ 98%. The track angle effect on the efficiency was also studied. Our results show that resistive techniques induce no degradation on the efficiency or resolution, with respect to the standard Micromegas. In some configuration the resistive coating is able to reduce the discharge currents at least by a factor of 100 and no HV breakdown was observed.

  14. HUNTING FOR PLANETS IN THE HL TAU DISK

    Energy Technology Data Exchange (ETDEWEB)

    Testi, L. [ESO, Karl Schwarzschild str. 2, D-85748 Garching bei Muenchen (Germany); Skemer, A.; Bailey, V.; Defrère, D.; Hinz, Ph.; Leisenring, J.; Vaz, A. [Steward Observatory, University of Arizona, 933 N. Cherry Ave., Tucson, AZ 85721 (United States); Henning, Th. [Max Planck Institute for Astronomie, Königstuhl 17, D-69117 Heidelberg (Germany); Esposito, S. [INAF-Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy); Fontana, A. [INAF-Osservatorio Astronomico di Roma, Monte Porzio (Italy); Marconi, A. [Universitá degli Studi di Firenze, Dipartimento di Fisica e Astronomia, Firenze (Italy); Skrutskie, M. [University of Virginia, 530 McCormick Road, Charlottesville, VA 22904 (United States); Veillet, C., E-mail: ltesti@eso.org [LBT Observatory, University of Arizona, 933 N. Cherry Ave., Tucson, AZ 85721 (United States)

    2015-10-20

    Recent ALMA images of HL Tau show gaps in the dusty disk that may be caused by planetary bodies. Given the young age of this system, if confirmed, this finding would imply very short timescales for planet formation, probably in a gravitationally unstable disk. To test this scenario, we searched for young planets by means of direct imaging in the L′ band using the Large Binocular Telescope Interferometer mid-infrared camera. At the location of two prominent dips in the dust distribution at ∼70 AU (∼0.″5) from the central star, we reach a contrast level of ∼7.5 mag. We did not detect any point sources at the location of the rings. Using evolutionary models we derive upper limits of ∼10–15 M{sub Jup} at ≤0.5–1 Ma for the possible planets. With these sensitivity limits we should have been able to detect companions sufficiently massive to open full gaps in the disk. The structures detected at millimeter wavelengths could be gaps in the distributions of large grains on the disk midplane caused by planets not massive enough to fully open the gaps. Future ALMA observations of the molecular gas density profile and kinematics as well as higher contrast infrared observations may be able to provide a definitive answer.

  15. Physics at HL-LHC with the upgraded ATLAS detector

    CERN Document Server

    Dell'Acqua, Andrea; The ATLAS collaboration

    2017-01-01

    The physics prospects at the luminosity upgrade of LHC, HL-LHC, with a data set equivalent to 3000 fb-1 simulated in the ATLAS detector, are presented and discussed. The ultimate precision attainable on measurements of 125 GeV Higgs boson couplings to elementary fermions and bosons is discussed, as well as the searches for partners associated with this new particle. The electroweak sector is further studied with the analysis of the vector boson scattering, testing the SM predictions at the LHC energy scale. Supersymmetry is still one of the best motivated extensions of the Standard Model. The current searches at the LHC have yielded sensitivity to TeV scale gluinos and 1st and 2nd generation squarks, as well as to 3rd generation squarks. The sensitivity to electro-weakinos has reached the hundreds of GeV mass range. Benchmark studies are presented to show how the sensitivity improves at the future high-luminosity LHC runs. Prospects for searches for new heavy bosons and dark matter candidates at 14 TeV pp col...

  16. Performances of Anode-resistive Micromegas for HL-LHC

    CERN Document Server

    Manjarres, J.; Attié, D.; Boyer, M.; Derré, J.; Fanourakis, G.; Ferrer-Ribas, E.; Galán, J.; Gazis, E.; Geralis, T.; Giganon, A.; Giomataris, I.; Herlant, S.; Jeanneau, F.; Schune, Ph.; Titov, M.; Tsipolitis, G.

    2012-03-20

    Micromegas technology is a promising candidate to replace Atlas forward muon chambers -tracking and trigger- for future HL-LHC upgrade of the experiment. The increase on background and pile-up event probability requires detector performances which are currently under studies in intensive RD activities. We studied performances of four different resistive Micromegas detectors with different read-out strip pitches. These chambers were tested using \\sim120 GeV momentum pions, at H6 CERN-SPS beam line in autumn 2010. For a strip pitch 500 micrometers we measure a resolution of \\sim90 micrometers and a efficiency of ~98%. The track angle effect on the efficiency was also studied. Our results show that resistive techniques induce no degradation on the efficiency or resolution, with respect to the standard Micromegas. In some configuration the resistive coating is able to reduce the discharge currents at least by a factor of 100.Micromegas technology is a promising candidate to replace Atlas forward muon chambers -tr...

  17. Experimental progress and innovation on the HL-2A tokamak

    International Nuclear Information System (INIS)

    Ding Xuantong

    2010-01-01

    The HL-2A Tokamak is the first large controlled fusion experiment device with divertor in China. In this paper, the main experimental results on this device will be presented. Since its establishment, the operation conditions have been improved greatly. First, the divertor configuration was realized, the electron temperature was increased to 5.5 keV by electron cyclotron heating, and then the high confinement edge localized mode was achieved. With the development of high power auxiliary heating and advanced plasma diagnostic systems,innovative contributions have been made in certain plasma physics areas. The 3-dimension structure of the zonal flow has been identified, which is very important in the transport of fusion plasma. Supersonic molecular beam injection has also been developed and successfully used for plasma transport. The tearing mode has been suppressed by electron cyclotron resonance heating with low frequency modulation, and the confinement has been improved. The new phenomena of the internal kink mode and Alfen mode excited by energetic electrons have been observed. Future plans and new experiments on the device will also be briefly presented. (authors)

  18. HUNTING FOR PLANETS IN THE HL TAU DISK

    International Nuclear Information System (INIS)

    Testi, L.; Skemer, A.; Bailey, V.; Defrère, D.; Hinz, Ph.; Leisenring, J.; Vaz, A.; Henning, Th.; Esposito, S.; Fontana, A.; Marconi, A.; Skrutskie, M.; Veillet, C.

    2015-01-01

    Recent ALMA images of HL Tau show gaps in the dusty disk that may be caused by planetary bodies. Given the young age of this system, if confirmed, this finding would imply very short timescales for planet formation, probably in a gravitationally unstable disk. To test this scenario, we searched for young planets by means of direct imaging in the L′ band using the Large Binocular Telescope Interferometer mid-infrared camera. At the location of two prominent dips in the dust distribution at ∼70 AU (∼0.″5) from the central star, we reach a contrast level of ∼7.5 mag. We did not detect any point sources at the location of the rings. Using evolutionary models we derive upper limits of ∼10–15 M Jup at ≤0.5–1 Ma for the possible planets. With these sensitivity limits we should have been able to detect companions sufficiently massive to open full gaps in the disk. The structures detected at millimeter wavelengths could be gaps in the distributions of large grains on the disk midplane caused by planets not massive enough to fully open the gaps. Future ALMA observations of the molecular gas density profile and kinematics as well as higher contrast infrared observations may be able to provide a definitive answer

  19. Experimental investigation of molecular beam injection in HL-1 tokamak

    International Nuclear Information System (INIS)

    Yao Lianghua; Diao Guangyao; Wang Zhanhe; Deng Huichen; Luo Junlin; Duan Xuru; Cui Zhengying

    1993-07-01

    A new method of gas puffing is presented. The molecular beam, formed by high pressure deuterium gas through Larval nozzle and skimmer slit, is injected into the HL-1 vacuum vessel. The deuterium molecular current from the nozzle passing through the skimmer is about 3 x 10 20 /s. At the line average electron density of 5.2 x 10 19 m -3 , the beam velocity is about 100 m/s. As the plasma density and temperature increasing, the influxes of deuterium particles attenuate quickly. When the molecular beam injection (MBI) just returned to normal gas puffing, the D α emission rapidly decreases, meanwhile, the particles move toward plasma center, the electron density is continuously peaking. The line average electron density rising lasts 45 ms. The thermal energy of plasma and confinement time for particles and energy are also increasing. the MBI is a direct and efficient gas fuelling mode, and the injected particles can reach to inside about 8 cm of plasma and q ≅ 2 confinement region. Its efficiency of injection is about 50%. After the MBI, the particle recycling coefficient R on the wall is 0.6 which is 10% lower than that of normal gas puffing

  20. An ATLAS distributed computing architecture for HL-LHC

    CERN Document Server

    Campana, Simone; The ATLAS collaboration

    2017-01-01

    The ATLAS collaboration started a process to understand the computing needs for the High Luminosity LHC era. Based on our best understanding of the computing model input parameters for the HL-LHC data taking conditions, results indicate the need for a larger amount of computational and storage resources with respect of the projection of constant yearly budget for computing in 2026. Filling the gap between the projection and the needs will be one of the challenges in preparation for LHC Run-4. While the gains from improvements in offline software will play a crucial role in this process, a different model for data processing, management, access and bookkeeping should also be envisaged to optimise resource usage. In this contribution we will describe a straw man of this model, founded on basic principles such as single event level granularity for data processing and virtual data. We will explain how the current architecture will evolve adiabatically into the future distributed computing system, through the prot...

  1. ATLAS Pixel Detector Design For HL-LHC

    CERN Document Server

    Smart, Ben; The ATLAS collaboration

    2016-01-01

    The ATLAS Inner Detector will be replaced for the High-Luminosity LHC (HL-LHC) running in 2026. The new Inner Detector will be called the Inner Tracker (ITk). The ITk will cover an extended eta-range: at least to |eta|<3.2, and likely up to |eta|<4.0. The ITk will be an all-Silicon based detector, consisting of a Silicon strip detector outside of a radius of 362mm, and a Silicon pixel detector inside of this radius. Several novel designs are being considered for the ITk pixel detector, to cope with high-eta charged particle tracks. These designs are grouped into 'extended' and 'inclined' design-types. Extended designs have long pixel staves with sensors parallel to the beamline. High-eta particles will therefore hit these sensors at shallow angles, leaving elongated charge clusters. The length of such a charge cluster can be used to estimate the angle of the passing particle. This information can then be used in track reconstruction to improve tracking efficiency and reduce fake rates. Inclined designs ...

  2. Spontaneous release of soluble HL-A antigens from platelets during conservation.

    Science.gov (United States)

    Dautigny, A; Bernier, I; Colombani, J; Jollès, P

    1975-01-01

    Experiments with the aim of studying the solubilisation of HL-A antigens from blood platelets by methods which do not involve any biologically active processes (moderate, discontinuous agitation of a low concentration of platelets suspended in a saline medium, in the presence of an antiseptic; supernatants collected at frequent intervals) have shown that platelets release membrane proteins, including HL-A antigens, spontaneously. Optimal conditions for the treatment of membrane proteins have been perfected. The great stability of HL-A antigens under these conditions permits prolonged treatment. The products extracted are soluble and extremely complex. The molecular weight of the HL-A antigens is between 40,000 and 70,000.

  3. A discussion on practicable scheme for machine control system of HL-2A tokamak

    International Nuclear Information System (INIS)

    Li Qiang; Song Xianming; Jiang Chao

    2001-01-01

    This is the modified version of The Preliminary Design on the Hardware and Nets of HL-2A Tokamak. In this version, centralized control as well as the field bus communication on HL-2A Tokamak is used. The hardware components and the operational theory are introduced. The questions of practice program, extensibility, centralized control, cooperation with other subsystems and the continuous adaptation of present device are all discussed. The budget of the system is detailed. To keep the step with the overall engineering constructions of HL-2A, suggestions of the time program are presented for the system design, instrument purchases, installation, construction, user program development and the final operation processes for the machine control system of HL-2A Tokamak

  4. Nenápadné významy Hlávkova mostu

    Czech Academy of Sciences Publication Activity Database

    Hnídková, Vendula

    2015-01-01

    Roč. 94, č. 12 (2015), s. 722-724 ISSN 0042-4544 Institutional support: RVO:68378033 Keywords : Czech modern architecture * Pavel Janák * Hlávka bridge Subject RIV: AL - Art, Architecture , Cultural Heritage

  5. Expected performance of tracking and vertexing with the HL-LHC ATLAS detector

    CERN Document Server

    Calace, Noemi; The ATLAS collaboration

    2018-01-01

    The High Luminosity LHC (HL-LHC) aims to increase the LHC data-set by an order of magnitude in order to increase its potential for discoveries. Starting from the middle of 2026, the HL-LHC is expected to reach the peak instantaneous luminosity of $7.5 \\cdot 10^{34} cm^{-2}s^{-1}$ which corresponds to about 200 inelastic proton-proton collisions per beam crossing. To cope with the large radiation doses and high pileup, the current ATLAS Inner Detector will be replaced with a new all-silicon Inner Tracker. In this talk the expected performance of tracking and vertexing with the HL-LHC tracker is presented. Comparison is made to the performance with the Run2 detector. Ongoing developments of the track reconstruction for the HL-LHC are also discussed.

  6. Initial analysis of the HL-2A tokamak visible light measurements

    International Nuclear Information System (INIS)

    Shi Le; Zheng Yinjia

    2005-01-01

    Measurement of H α radial distribution is an important part in a plasma experiment. During the HL-2A experiment, CCD photos recorded the plasma radiation information using a plasma imaging system, particularly the H α line emission information (with H α filter in front of the camera). Since the line of light radiation measurement involves a line integral of the radiating region, data handling and analysis are necessary. The H α radial distribution along an HL-2A tokamak radial radius can be obtained by using an Abel inversion transformation with plasma imaging on the HL-2A tokamak. This paper provides a reliable measurement method on the HL-2A tokamak. (authors)

  7. Tracking in Dense Environments for the HL-LHC ATLAS Detector

    CERN Document Server

    Cormier, Felix; The ATLAS collaboration

    2018-01-01

    Tracking in dense environments, such as in the cores of high-energy jets, will be key for new physics searches as well as measurements of the Standard Model at the High Luminosity LHC (HL-LHC). The HL-LHC will operate in challenging conditions with large radiation doses and high pile-up (up to $\\mu=200$). The current tracking detector will be replaced with a new all-silicon Inner Tracker for the Phase II upgrade of the ATLAS detector. In this talk, characterization of the HL-LHC tracker performance for collimated, high-density charged particles arising from high-momentum decays is presented. In such decays the charged-particle separations are of the order of the tracking detector granularity, leading to challenging reconstruction. The ability of the HL-LHC ATLAS tracker to reconstruct the tracks in such dense environments is discussed and compared to ATLAS Run-2 performance for a variety of relevant physics processes.

  8. The Supervisory Control System for the HL-2A Neutral Beam Injector

    Science.gov (United States)

    Li, Bo; Li, Li; Feng, Kun; Wang, Xueyun; Yang, Jiaxing; Huang, Zhihui; Kang, Zihua; Wang, Mingwei; Zhang, Guoqing; Lei, Guangjiu; Rao, Jun

    2009-06-01

    Supervisory control and protection system of the neutral beam injector (NBI) in the HL-2A tokamak is presented. The system is used for a safe coordination of all the main NBI subsystems. Because the system is based on computer networks with its transmission medium of optical fiber, its advantages in high operational stability, reliability, security and flexible functional expandability are clearly shown during the NBI commissioning and heating experiment in HL-2A.

  9. EVALUATION OF RISKS AND WASTE CHARACTERIZATION REQUIREMENTS FOR THE TRANSURANIC WASTE EMPLACED IN WIPP DURING 1999

    International Nuclear Information System (INIS)

    Channell, J.K.; Walker, B.A.

    2000-01-01

    Specifically this report: 1. Compares requirements of the WAP that are pertinent from a technical viewpoint with the WIPP pre-Permit waste characterization program, 2. Presents the results of a risk analysis of the currently emplaced wastes. Expected and bounding risks from routine operations and possible accidents are evaluated; and 3. Provides conclusions and recommendations

  10. High-precision 40Ar/39AR age of the gas emplacement into the Songliao Basin

    NARCIS (Netherlands)

    Qiu, H.N.; Wu, H.Y.; Yun, Y.B.; Feng, Z.H.; Xu, Y.G.; Mei, L.F.; Wijbrans, J.R.

    2011-01-01

    The problem of determining an exact isotopic age of hydrocarbon emplacement is complex because minerals suitable for dating with common isotopic methods are often lacking in the sedimentary domain. However, the igneous quartz from the Cretaceous volcanic rocks that host the gas reservoir in the

  11. Strike-slip pull-apart process and emplacement of Xiangshan uranium-producing volcanic basin

    International Nuclear Information System (INIS)

    Qiu Aijin; Guo Lingzhi; Shu Liangshu

    2001-01-01

    Xiangshan volcanic basin is one of the famous uranium-producing volcanic basins in China. Emplacement mechanism of Xiangshan uranium-producing volcanic basin is discussed on the basis of the latest research achievements of deep geology in Xiangshan area and the theory of continental dynamics. The study shows that volcanic activity in Xiangshan volcanic basin may be divided into two cycles, and its emplacement is controlled by strike-ship pull-apart process originated from the deep regional faults. Volcanic apparatus in the first cycle was emplaced in EW-trending structure activated by clockwise strike-slipping of NE-trending deep fault, forming the EW-trending fissure-type volcanic effusion belt. Volcanic apparatus in the second cycle was emplaced at junction points of SN-trending pull-apart structure activated by sinistral strike-slipping of NE-trending deep faults and EW-trending basement faults causing the center-type volcanic magma effusion and extrusion. Moreover, the formation mechanism of large-rich uranium deposits is discussed as well

  12. From Embodiment to Emplacement: Re-Thinking Competing Bodies, Senses and Spatialities

    Science.gov (United States)

    Pink, Sarah

    2011-01-01

    In this article I discuss how a shift from theories of embodiment to one of emplacement can inform how we understand the performing body in competitive and pedagogical contexts. I argue that recent theoretical advances concerning the senses, human perception and place offer new analytical possibilities for understanding skilled performances and…

  13. Preliminary clinical study of 99Tcm-HL91 imaging in bone metastasis

    International Nuclear Information System (INIS)

    Liu Baoping; Mao Ronghu; Han Xingmin

    2008-01-01

    Objective: 99 Tc m -4, 9-diaza-3, 3, 10, 10-tetramethyldodecan-2, 11-dione dioxime (HL91), a new type of hypoxic agents, accumulates in tumor hypoxic tissue specifically. The aim of this study was to evaluate the value of 99 Tc m -HL91 imaging in the diagnosis of bone metastasis. Methods: Nine- teen cases with bone metastasis (without any treatment) and 8 cases with benign lesions underwent SPECT imaging at 4 h after injection of 740 MBq of 99 Tc m -HL91 along with 99 Tc m -methylene diphosphonic acid (MDP) imaging. Regions of interest (ROIs) were drawn in tumor tissue and contralateral normal tissue respectively, and the radioactivity ratios of tumor-to-normal (T/N) were calculated. The t-test was used for data analysis with SPSS 11.0. Results: There were visible uptake of 99 Tc m -HL91 in 79 out of 85 focuses in 19 patients of bone metastasis; however, there was no obvious uptake of 99 Tc m -HL91 in 12 focuses of 8 patients of benign lesions. Significant difference existed between the T/N values of malignant (1.877 ± 0.288) and benign lesions [(0.735 ± 0.236); t=13.065, P 0.05). Conclusion: The results indicated that 99 Tc m -HL91 was useful in diagnosing the malignant and benign bone lesions. (authors)

  14. Preliminary applied study of assessment ischemic/viable myocardium by 99Tcm-HL91

    International Nuclear Information System (INIS)

    Liu Gang; Wu Hua

    2004-01-01

    Objective: To investigate the representation of 99 Tc m -HL91 in the ischemic myocardium, evaluate the diagnosis value of 99 Tc m -HL91 on hypoxic but viable myocardium. Methods: Six patients with cardiac infarction all underwent 99 Tc m -MIBI SPECT and 99 Tc m -HL91 SPECT. Average radioactivity of ischemic area and normal area were respectively obtained by ROI (2 x 2 pixels) on heart minor axis of images, And the radioactivity ratios of target (ischemic area)-to-non target(normal area)were calculated. Results: In image of 99 Tc m -HL91 SPECT, two patients who's radioactivity coloboma of 99 Tc m -MIBI image could be filled with 99 Tc m -HL91, four patients were not caught sight of obvious filling up. Conclusion 99 Tc m -HL91 can be selectively uptaken by ischemic and hypoxic but viable myocardium. it combination of 99 Tc m -MIBI SPECT may be good for accurate diagnosis and differentiation of viable myocardium. (authors)

  15. Origin of elevated water levels encountered in Pahute Mesa emplacement boreholes: Preliminary investigations

    International Nuclear Information System (INIS)

    Brikowski, T.; Chapman, J.; Lyles, B.; Hokett, S.

    1993-11-01

    The presence of standing water well above the predicted water table in emplacement boreholes on Pahute Mesa has been a recurring phenomenon at the Nevada Test Site (NTS). If these levels represent naturally perched aquifers, they may indicate a radionuclide migration hazard. In any case, they can pose engineering problems in the performance of underground nuclear tests. The origin of these elevated waters is uncertain. Large volumes of water are introduced during emplacement drilling, providing ample source for artificially perched water, yet elevated water levels can remain constant for years, suggesting a natural origin instead. In an effort to address the issue of unexpected standing water in emplacement boreholes, three different sites were investigated in Area 19 on Pahute Mesa by Desert Research Institute (DRI) staff from 1990-93. These sites were U-19az, U-19ba, and U-19bh. As of this writing, U-19bh remains available for access; however, nuclear tests were conducted at the former two locations subsequent to this investigations. The experiments are discussed in chronological order. Taken together, the experiments indicate that standing water in Pahute Mesa emplacement holes originates from the drainage of small-volume naturally perched zones. In the final study, the fluids used during drilling of the bottom 100 m of emplacement borehole U-19bh were labeled with a chemical tracer. After hole completion, water level rose in the borehole, while tracer concentration decreased. In fact, total mass of tracer in the borehole remained constant, while water levels rose. After water levels stabilized in this hole, no change in tracer mass was observed over two years, indicating that no movement of water out of the borehole is taking place (as at U- 19ba). Continued labeling tests of standing water are recommended to confirm the conclusions made here, and to establish their validity throughout Pahute Mesa

  16. Buffered and unbuffered dike emplacement on Earth and Venus - Implications for magma reservoir size, depth, and rate of magma replenishment

    Science.gov (United States)

    Parfitt, E. A.; Head, J. W., III

    1993-01-01

    Models of the emplacement of lateral dikes from magma chambers under constant (buffered) driving pressure conditions and declining (unbuffered) driving pressure conditions indicate that the two pressure scenarios lead to distinctly different styles of dike emplacement. In the unbuffered case, the lengths and widths of laterally emplaced dikes will be severely limited and the dike lengths will be highly dependent on chamber size; this dependence suggests that average dike length can be used to infer the dimensions of the source magma reservoir. On Earth, the characteristics of many mafic-dike swarms suggest that they were emplaced in buffered conditions (e.g., the Mackenzie dike swarm in Canada and some dikes within the Scottish Tertiary). On Venus, the distinctive radial fractures and graben surrounding circular to oval features and edifices on many size scales and extending for hundreds to over a thousand km are candidates for dike emplacement in buffered conditions.

  17. CASTOR registered HAW28M - a high heat load cask for transport and storage of vitrified high level waste containers

    International Nuclear Information System (INIS)

    Vossnacke, A.; Klein, K.; Kuehne, B.

    2004-01-01

    Within the German return programme for vitrified high level waste (HLW) from reprocessing at COGEMA and BNFL up to now 39 casks loaded with 28 containers each were transported back to Germany and are stored in the Interim Storage Facility Gorleben (TBL-G) for up to 40 years. For transport and storage in all but one case the GNB casks CASTOR registered HAW 20/28 CG have been used. This cask type is designed to accommodate 20 or 28 HLW containers with a total thermal power of 45 kW maximum. In the near future, among the high level waste, which has to be returned to Germany, there will be an increasing number of containers of which the heat capacity and radioactive inventory will exceed the technical limits of the CASTOR registered HAW 20/28 CG. Therefore GNB has started the development of a new cask generation, named CASTOR registered HAW28M, meeting these future requirements. The CASTOR registered HAW28M is especially developed for the transport of vitrified residues from France and Great Britain to Germany. It complies with the international regulations for type B packages according to IAEA (International Atomic Energy Agency). It is thus guaranteed that even in case of any accident the cask body and the lid system remain functional and the safe confinement of the radioactive contents remains intact during transport. The CASTOR registered HAW28M fulfills not only the requirements for transport but also the acceptance criteria of interim storage: radiation shielding, heat dissipation, safe confinement under both normal and hypothetical accident conditions. Storage buildings such as the TBL-G simply support the safety functions of the cask. The challenge for the development results from higher requirements of the technical specification, particularly related to fuel which is reprocessed. As a consequence of the reprocessing of fuel with increased enrichment and burn up, higher heat capacity and sophisticated shielding measures have to be considered. For the CASTOR

  18. Raman spectrum reveals Mesenchymal stem cells inhibiting HL60 cells growth

    Science.gov (United States)

    Su, Xin; Fang, Shaoyin; Zhang, Daosen; Zhang, Qinnan; Lu, Xiaoxu; Tian, Jindong; Fan, Jinping; Zhong, Liyun

    2017-04-01

    Though some research results reveals that Mesenchymal stem cells (MSCs) have the ability of inhibiting tumor cells proliferation, it remains controversial about the precise interaction mechanism during MSCs and tumor cells co-culture. In this study, combing Raman spectroscopic data and principle component analysis (PCA), the biochemical changes of MSCs or Human promyelocytic leukemia (HL60) cells during their co-culture were presented. The obtained results showed that some main Raman peaks of HL60 assigned to nucleic acids or proteins were greatly higher in intensity in the late stage of co-culture than those in the early stage of co-culture while they were still lower relative to the control group, implicating that the effect of MSCs inhibiting HL60 proliferation appeared in the early stage but gradually lost the inhibiting ability in the late stage of co-culture. Moreover, some other peaks of HL60 assigned to proteins were decreased in intensity in the early stage of co-culture relative to the control group but rebounded to the level similar to the control group in the late stage, showing that the content and structure changes of these proteins might be generated in the early stage but returned to the original state in the late stage of co-culture. As a result, in the early stage of MSCs-HL60 co-culture, along with the level of Akt phosphorylation of HL60 was lowered relative to its control group, the proliferation rate of HL60 cells was decreased. And in the late stage of co-culture, along with the level of Akt phosphorylation was rebounded, the reverse transfer of Raman peaks within 875-880 cm- 1 appeared, thus MSCs lost the ability to inhibit HL60 growth and HL60 proliferation was increased. In addition, it was observed that the peak at 811 cm- 1, which is a marker of RNA, was higher in intensity in the late stage than that in the control group, indicating that MSCs might be differentiated into myofibroblast-like MSCs. In addition, PCA results also exhibited

  19. Cytotoxicity and cellular uptake of doxorubicin and its formamidine derivatives in HL60 sensitive and HL60/MX2 resistant cells.

    Science.gov (United States)

    Kik, Krzysztof; Wasowska-Lukawska, Malgorzata; Oszczapowicz, Irena; Szmigiero, Leszek

    2009-04-01

    In this work a comparison was made of the cytotoxicity and cellular uptake of doxorubicin (DOX) and two of its derivatives containing a formamidino group (-N=CH-N<) at the 3' position with morpholine (DOXM) or hexamethyleneimine (DOXH) ring. All tests were performed in doxorubicin-sensitive HL60 and -resistant HL60/MX2 cells which are known for the presence of altered topoisomerase II. Cytotoxic activity of DOX toward HL60/MX2 cells was about 195 times lower when compared with the sensitive HL60 cell line. DOXM and DOXH were approximately 20 times more active in resistant cells than DOX. It was found that the uptake of DOX was lower in resistant cells by about 16%, while that of DOXM and DOXH was lower by about 36% and 19%, respectively. Thus the changes in the cellular uptake of anthracyclines are not associated with the fact that cytotoxicity of DOXM and DOXH exceed the cytotoxicity of DOX. Experiments in cell-free system containing human topoisomerase II showed that topoisomerase II is not inhibited by DOXM and DOXH. Formamidinoanthracyclines may be more useful than parent drugs in therapy against tumor cells with altered topoisomerase II activity.

  20. Loading, transport and storage of casks of the type CASTOR registered HAW28M in the frame of vitrified high-level waste repatriation from France

    International Nuclear Information System (INIS)

    Horn, Thomas; Graf, Wilhelm; Gosch-Warning, Michaela

    2011-01-01

    Until 2005 the German nuclear power plant operators have contracts with AREVA NC (former COGEMA) and NDA (former BNFL) concerning the reprocessing of spent fuel elements. The reprocessed and vitrified radioactive waste has to be repatriated to Germany. Due to the reprocessing of spent fuel elements with increased burnup and the repatriation after shorter cooling time the total activity and the Cm-244 content of the high-level-waste coquilles have increased since 2008. Consequently the heat output has increased to 2 kW/coquille. Therefore the new transport cask type CASTOR registered HAW28M was developed. The authors describe the design of the casks, the licensing according to the German transport regulations, loading procedures, radiation measurements and shipment completion. In autumn 2011 the repatriation of vitrified high-level waste from France is supposed to be completed with the transport of eleven CASTOR registered HAW28M.

  1. Comparison of vitrified and unvitrified Eocene woody tissues by TMAH thermochemolysis – implications for the early stages of the formation of vitrinite

    Directory of Open Access Journals (Sweden)

    Huggett William W

    2006-10-01

    Full Text Available Abstract Samples of vitrified and unvitrified Eocene woody plant tissues collected from the Fossil Forest site, Geodetic Hills, Axel Heiberg Island, have been characterized by TMAH thermochemolysis. All samples are gymnosperm-derived, are of very low maturity and all share the same post-depositional geologic history. Differences in the distributions of products observed from vitrified and unvitrified samples suggest that vitrification of woody tissue is associated with modification of the lignin C3 side chain, following loss of all or most of the carbohydrate present in the precursor woody tissues. The key driver of vitrification appears to be physical compression of the tissue following biological removal of cellulosic materials.

  2. Shielding calculations with SCALE/MAVRIC and comparison with measurements for the TN85 cask with vitrified high level radioactive waste

    Science.gov (United States)

    Thiele, Holger; Börst, Frank-Michael

    2017-09-01

    A series of dose rate/spectra measurements in the German interim storage facility Gorleben was carried out at a TN85 cask in April 2009. This type of cask is used for the transport and interim storage of vitrified high level radioactive waste (HAW) from reprocessing. The aim of this work is to assess the shielding component MAVRIC of the SCALE code system with these measurements for the use in the German Bundesamt für Kerntechnische Entsorgungssicherheit (BfE).

  3. Vitrified waste form performance modeling applied to the treatment and disposal of mixed-waste sludge at the Savannah River Site

    International Nuclear Information System (INIS)

    Whited, A.R.; Fjeld, R.A.

    1998-01-01

    Vitrification, the conversion of source components into a solid amorphous glass matrix, has emerged as a viable treatment technology for low-level radioactive waste and mixed waste. To dispose of vitrified low-level waste at US Department of Energy facilities, site-specific radiological performance assessments must be conducted to demonstrate that waste glass satisfies performance objectives for environmental protection. More than 2,500 m 3 of F0006-listed low-level mixed-waste sludge stored in the Reactor Materials Department (M-Area) at the Savannah River Site (SRS) is scheduled for vitrification. This study evaluates the feasibility of on-site disposal of vitrified M-Area waste at SRS. Laboratory leaching tests that accelerate the glass corrosion process are currently the best indicators of vitrified waste form durability. A method to incorporate laboratory leaching data into performance assessments is presented. A screening-level performance assessments code is used to model trench disposal of M-Area waste glass. The allowable leach rate for vitrified M-Area waste is determined based on both a maximum radiological dose equivalent of 4 mrem/yr for the drinking water pathway and a maximum uranium concentration of 20 microg/ell in groundwater. The allowable leach rate is compared with published long-term leaching data for a wide range of waste glass compositions and test conditions. This analysis demonstrates that trench disposal of the waste glass is likely to meet applicable performance objectives if the glass is of above average durability compared with the reference set of glasses

  4. Developmental Competence of Vitrified-Warmed Bovine Oocytes at the Germinal-Vesicle Stage is Improved by Cyclic Adenosine Monophosphate Modulators during In Vitro Maturation.

    Directory of Open Access Journals (Sweden)

    Kenji Ezoe

    Full Text Available Cryopreservation of mature oocytes and embryos has provided numerous benefits in reproductive medicine. Although successful cryopreservation of germinal-vesicle stage (GV oocytes holds promise for further advances in reproductive biology and clinical embryology fields, reports regarding cryopreservation of immature oocytes are limited. Oocyte survival and maturation rates have improved since vitrification is being performed at the GV stage, but the subsequent developmental competence of GV oocytes is still low. The purpose of this study was to evaluate the effects of supplementation of the maturation medium with cyclic adenosine monophosphate (cAMP modulators on the developmental competence of vitrified-warmed GV bovine oocytes. GV oocytes were vitrified-warmed and cultured to allow for oocyte maturation, and then parthenogenetically activated or fertilized in vitro. Our results indicate that addition of a cAMP modulator forskolin (FSK or 3-isobutyl-1-methylxanthine (IBMX to the maturation medium significantly improved the developmental competence of vitrified-warmed GV oocytes. We also demonstrated that vitrification of GV oocytes led to a decline in cAMP levels and maturation-promoting factor (MPF activity in the oocytes during the initial and final phases of maturation, respectively. Nevertheless, the addition of FSK or IBMX to the maturation medium significantly elevated cAMP levels and MPF activity during IVM. Taken together, our results suggest that the cryopreservation-associated meiotic and developmental abnormalities observed in GV oocytes may be ameliorated by an artificial increase in cAMP levels during maturation culture after warming.

  5. Cryostorage duration does not affect pregnancy and neonatal outcomes: a retrospective single-centre cohort study of vitrified-warmed blastocysts.

    Science.gov (United States)

    Ueno, Satoshi; Uchiyama, Kazuo; Kuroda, Tomoko; Yabuuchi, Akiko; Ezoe, Kenji; Okimura, Tadashi; Okuno, Takashi; Kobayashi, Tamotsu; Kato, Keiichi

    2018-06-01

    A retrospective cohort study of 8736 autologous single vitrified-warmed blastocyst transfer cycles was conducted in a single centre to investigate the effect of cryostorage on clinical and neonatal outcomes. Cryostorage duration was classified into three groups: (A) 0-2 months (n = 4702); (B) 2-13 months (n = 2853) and (C) 13-97 months (n = 1181). Blastocysts were vitrified using the Cryotop method. No significant differences were observed in live birth rates: (A) 37.3%; (B) 34.9%; (C) (35.2%). Gestational period was significantly shorter in group C: (A) 38.7 ± 1.8; (B) 38.6 ± 1.6; (C) 38.1 ± 1.7; P limitation of this study was that maximum storage duration was 8 years; most blastocysts were in cryostorage for much shorter periods. Long-term storage of blastocysts that are vitrified using an open device vitrification system has no negative effect on pregnancy and neonatal outcomes. Copyright © 2018 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  6. An experimental study on cerebral ischemic penumbra imaging with 99Tcm-HL91

    International Nuclear Information System (INIS)

    Zhu Cansheng; Jiang Ningyi

    2002-01-01

    Objective: To investigate the biodistribution of 99 Tc m -4,9-diaza-3,3,10,10-tetramethyl dodecan-2,11-dione dioxime (HL91) in rat model of middle cerebral artery occlusion (MCAO). Methods: Thirty-one MCAO rats were established. Fourteen rats were used to study the biodistribution of 99 Tc m -HL91 and 15 rats were used to study the distribution of 99 Tc m -HL91 in the brain of MCAO model rats. Autoradiographic study of brain was also done in 16 MCAO model rats. Results: The liver and kidney retention were higher than that in other tissues. At 1 h after injection, small intestine retention was also high. But radioactivity in normal brain was low. Retention in target site was higher than that in non-target site. Difference between subgroups of operation and that of pseudo operation was significant (P 99 Tc m -HL91 at the target-ischemic area was shown in the autoradiograph. By using computer-enhanced image analysis, difference between target site and non-target site in the same autoradiograph and the differences between operation subgroups and that of pseudo-subgroups were all significant via Dunnett t-test and One-Way ANOVA. Conclusions: 99 Tc m -HL91 can be avidly taken up by ischemic penumbra and target/non-target ratio is high. 99 Tc m -HL91 is a potential agent for hypoxic tissue imaging, and 99 Tc m -HL91 SPECT is a promising modality in detecting the ischemic penumbra

  7. Uric acid disrupts hypochlorous acid production and the bactericidal activity of HL-60 cells.

    Science.gov (United States)

    Carvalho, Larissa A C; Lopes, João P P B; Kaihami, Gilberto H; Silva, Railmara P; Bruni-Cardoso, Alexandre; Baldini, Regina L; Meotti, Flavia C

    2018-06-01

    Uric acid is the end product of purine metabolism in humans and is an alternative physiological substrate for myeloperoxidase. Oxidation of uric acid by this enzyme generates uric acid free radical and urate hydroperoxide, a strong oxidant and potentially bactericide agent. In this study, we investigated whether the oxidation of uric acid and production of urate hydroperoxide would affect the killing activity of HL-60 cells differentiated into neutrophil-like cells (dHL-60) against a highly virulent strain (PA14) of the opportunistic pathogen Pseudomonas aeruginosa. While bacterial cell counts decrease due to dHL-60 killing, incubation with uric acid inhibits this activity, also decreasing the release of the inflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF- α). In a myeloperoxidase/Cl - /H 2 O 2 cell-free system, uric acid inhibited the production of HOCl and bacterial killing. Fluorescence microscopy showed that uric acid also decreased the levels of HOCl produced by dHL-60 cells, while significantly increased superoxide production. Uric acid did not alter the overall oxidative status of dHL-60 cells as measured by the ratio of reduced (GSH) and oxidized (GSSG) glutathione. Our data show that uric acid impairs the killing activity of dHL-60 cells likely by competing with chloride by myeloperoxidase catalysis, decreasing HOCl production. Despite diminishing HOCl, uric acid probably stimulates the formation of other oxidants, maintaining the overall oxidative status of the cells. Altogether, our results demonstrated that HOCl is, indeed, the main relevant oxidant against bacteria and deviation of myeloperoxidase activity to produce other oxidants hampers dHL-60 killing activity. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

  8. Application of 99Tcm-HL-91 in the hypoxia study of malignant lymphoma

    International Nuclear Information System (INIS)

    Li Li; Han Peizhen; Yan Yujun; Wang Yueying; Wang Junqi; Li Meijia

    2002-01-01

    Objective: 99 Tc m -HL91 is a putative hypoxic tracer probing hypoxia in solid tumors. This study was aimed at investigating the property of the spontaneous IRM-2-ML malignant lymphoma in homozygotic IRM-2 mice, and at testing the applicability of 99 Tc m -HL91 to the imaging of hypoxia in tumors. Methods: Biodistribution of 99 Tc m -HL91 after intravenously injection into normal and tumor-bearing IRM-2 mice was studied by determining blood and tissue levels of radioactivity from 20 to 360 min after injection. Nicotinamide was used to reduce the extent of hypoxia in the tumors. Planar SPECT imaging on normal and tumor-bearing IRM-2 mice was also performed. Results: Tumor load did not significantly influence the retention of 99 Tc m -HL91 in normal organs. 99 Tc m -HL91 was metabolized mainly via the liver and kidney, and was cleared fast from the blood. The tumor-to-blood ratio and tumor-to-muscle ratio continued to increase until 360 min (2.63 +- 0.25 and 3.37 +- 0.22 at 120 min, 3.51 +- 0.17 and 6.44 +- 0.29 at 360 min, respectively). The retention of 99 Tc m -HL91 in the tumor was reduced in mice by treatment with nicotinamide. Planar SPECT imaging showed that tumor could be observed clearly. Conclusion: These results confirm that IRM-2-ML malignant lymphoma possesses the common property of solid tumors,and also indicate that 99 Tc m -HL91 could be used to detect tumor hypoxia

  9. Test of 134Cs, 85,89Sr leaching rate in a resemble vitrifiable cement waste form

    International Nuclear Information System (INIS)

    Lin Meiqiong; Wei Feng; Yin Qi; Fan Xianhua; Xu Shengli; Li Yongde

    2003-01-01

    A novel material--resemble vitrifiable cement for conditioning low and mediate level radioactive waste has been developed. Waste form has been characterized for their physical and chemical performance, phase composition. The cement formulation has been patented. In this experiment the cement is mixed with simulated wastes spiked with 134 Cs and 85,89 Sr by 5 min at least. The Ratio of the waste to the cement is 0.45-0.55. The mixture is packed into cylindrical molds which has the same dimension of diameter and height . The grouts are cured for a period of 28 d in a room temperature curing chamber at an atmospheric pressure. The cured waste form is then completely immersed into deionized water. According to standard GB7023-86, leaching rate of 134 Cs and 85,89 Sr are measured. The result shows that the leaching rate of the species 134 Cs and 85,89 Sr is to be on the order 10 -4 and 10 -5 on the 42 d immersion, respectively and is better than that of commercial cement

  10. FY-97 operations of the pilot-scale glass melter to vitrify simulated ICPP high activity sodium-bearing waste

    International Nuclear Information System (INIS)

    Musick, C.A.

    1997-11-01

    A 3.5 liter refractory-lined joule-heated glass melter was built to test the applicability of electric melting to vitrify simulated high activity waste (HAW). The HAW streams result from dissolution and separation of Idaho Chemical Processing Plant (ICPP) calcines and/or radioactive liquid waste. Pilot scale melter operations will establish selection criteria needed to evaluate the application of joule heating to immobilize ICPP high activity waste streams. The melter was fabricated with K-3 refractory walls and Inconel 690 electrodes. It is designed to be continuously operated at 1,150 C with a maximum glass output rate of 10 lbs/hr. The first set of tests were completed using surrogate HAW-sodium bearing waste (SBW). The melter operated for 57 hours and was shut down due to excessive melt temperatures resulting in low glass viscosity (< 30 Poise). Due to the high melt temperature and low viscosity the molten glass breached the melt chamber. The melter has been dismantled and examined to identify required process improvement areas and successes of the first melter run. The melter has been redesigned and is currently being fabricated for the second run, which is scheduled to begin in December 1997

  11. From steep feeders to tabular plutons - Emplacement controls of syntectonic granitoid plutons in the Damara Belt, Namibia

    Science.gov (United States)

    Hall, Duncan; Kisters, Alexander

    2016-01-01

    Granitoid plutons in the deeply eroded south Central Zone of the Damara Belt in Namibia commonly show tabular geometries and pronounced stratigraphic controls on their emplacement. Subhorizontal, sheet-like pluton geometries record emplacement during regional subhorizontal shortening, but the intrusion of spatially and temporally closely-related granitoid plutons at different structural levels and in distinct structural settings suggests independent controls on their levels of emplacement. We describe and evaluate the controls on the loci of the dyke-to-sill transition that initiated the emplacement of three syntectonic (560-530 Ma) plutons in the basement-cover stratigraphy of the Erongo region. Intrusive relationships highlight the significance of (1) rigidity anisotropies associated with competent sedimentary packages or pre-existing subhorizontal granite sheets and (2) rheological anisotropies associated with the presence of thick ductile marble horizons. These mechanical anisotropies may lead to the initial deflection of steep feeder conduits as well as subsequent pluton assembly by the repeated underaccretion of later magma batches. The upward displacement of regional isotherms due to the heat advection associated with granite emplacement is likely to have a profound effect on the mechanical stratification of the upper crust and, consequently, on the level at which granitoid pluton emplacement is initiated. In this way, pluton emplacement at progressively shallower crustal depths may have resulted in the unusually high apparent geothermal gradients recorded in the upper crustal levels of the Damara Belt during its later evolution.

  12. H/L transition time estimation in JET using conformal predictors

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, S., E-mail: sergio.gonzalez@ciemat.es [Asociacion EURATOM/CIEMAT para Fusion, Madrid 28040 (Spain); Vega, J. [Asociacion EURATOM/CIEMAT para Fusion, Madrid 28040 (Spain); Murari, A. [Consorzio RFX, Associazione EURATOM/ENEA per la Fusione, Padova 4-25127 (Italy); Pereira, A. [Asociacion EURATOM/CIEMAT para Fusion, Madrid 28040 (Spain); Dormido-Canto, S.; Ramirez, J.M. [Departamento de Informatica y Automatica, UNED, Madrid 28040 (Spain)

    2012-12-15

    Highlights: Black-Right-Pointing-Pointer H/L transitions have been predicted using H/L and L/H models. Black-Right-Pointing-Pointer Models have been built using conformal predictors to hedge the prediction with confidence and credibility measures. Black-Right-Pointing-Pointer Models have been trained using linear and radial basis function kernels. Black-Right-Pointing-Pointer Conformal measures have proven their usefulness to validate data-driven models. - Abstract: Recent advances in data mining allow the automatic recognition of physical phenomena in the databases of fusion devices without human intervention. This is important to create large databases of physical events (thereby increasing the statistical relevance) in an unattended manner. Important examples are the L/H and H/L transitions. In this contribution, a novel technique is introduced to automatically locate H/L transitions in JET by using conformal predictors. The focus is on H/L transitions because typically there is not a clear signature in the time series of the most widely available signals to recognize the change of confinement. Conformal predictors hedge their prediction by means of two parameters: confidence and credibility. The technique has been based on binary supervised classifiers to separate the samples of the respective confinement modes. Results with several underlying classifiers are presented.

  13. Relationship of calcitonin mRNA expression to the differentiation state of HL 60 cells.

    Science.gov (United States)

    Kiefer, P; Bacher, M; Pflüger, K H

    1994-05-01

    Raised plasma levels of immunoreactive human calcitonin (ihCT) can be found in patients with myeloid leukemia and seem to indicate a poor prognosis. High levels were found in acute undifferentiated and acute myeloblastic leukemia. To test whether CT expression could be a marker of myeloid differentiation, we used the promyelocytic leukemia cell line HL 60 which also expresses ihCT as a model system for myeloid differentiation. Exponentially growing HL 60 cells as well as differentiation induced HL 60 cells expressed a single 1.0 Kb CT transcript. The induction of HL 60 cell differentiation along the granulocytic lineage by DMSO or HMBA had no effect on the level of CT transcripts. Induction of monocytic/macrophagic differentiation by TPA resulted in a transient, about 10-fold elevated expression of CT steady state mRNA after 24 h. In contrast to TPA, induction of HL 60 cell differentiation along the monocytic pathway by Vit D3 had no detectable effect on the level of the CT in RNA expression at corresponding time points. These findings suggest that the transient induction of CT steady state mRNA expression by TPA is rather a direct effect of the phorbol ester than commitment along the monocytic line of differentiation.

  14. Use of hypoxia imaging agent 99mTc-HL91 in rat cerebral ischemia models

    International Nuclear Information System (INIS)

    Zhou Ying; Qu Wanying; Li Meng; Chen Fang; Yao Zhiming; Zhu Ming; Zhu Lin

    1999-01-01

    Objective: To explore the possibility of diagnosis for cerebrovascular disease by a novel synthetic hypoxia agent 99m Tc-HL91 used in rat cerebral ischemia models. Methods: Pharmacological experiments of 99m Tc-HL91 were carried out including common properties, radiochemical purity, stability in vitro, anomalous toxicity test and biodistribution in mice. Fifteen cerebral ischemic rat models were established and received 99m Tc-HL91 scintigraphy. Results: 1) HL91 kits were labelled with 99m Tc easily and showed high radiochemical purity and stability. 2) Rapid clearance in blood, heart and lungs and high activity in liver, kidneys and intestines were observed. Relatively low uptake in brain was identified. 3) The radioactivity in ischemic brain tissue increased significantly at 4h postinjection in both rat images and isolated brain images. 4) The radioactivity ratios of lesion to normal brain tissue by drawing ROIs in isolated brain planar images were 0.98 +- 0.06, 0.99 +- 0.05, 1.29 +- 0.03, 1.56 +- 0.14 and 1.66 +- 0.06 at 1,2,4,8 and 12 h postinjection, respectively. There were significant differences among all groups except for 1 h and 2 h, 8 h and 12 h postinjection (P 99m Tc-HL91 in the hypoxic, ischemic brain tissue have been proved. It is appropriate to perform imaging at 4 h postinjection

  15. Shapes of Venusian 'pancake' domes imply episodic emplacement and silicic composition

    Science.gov (United States)

    Fink, Jonathan H.; Bridges, Nathan T.; Grimm, Robert E.

    1993-01-01

    The main evidence available for constraining the composition of the large circular 'pancake' domes on Venus is their gross morphology. Laboratory simulations using polyethylene glycol show that the height to diameter (aspect) ratios of domes of a given total volume depend critically on whether their extrusion was continuous or episodic, with more episodes leading to greater cooling and taller domes. Thus without observations of their emplacement, the compositions of Venusian domes cannot be uniquely constrained by their morphology. However, by considering a population of 51 Venusian domes to represent a sampling of many stages during the growth of domes with comparable histories, and by plotting aspect ratio versus total volume, we find that the shapes of the domes are most consistent with episodic emplacement. On Earth this mode of dome growth is found almost exclusively in lavas of dacite to rhyolite composition, strengthening earlier inferences about the presence of evolved magmas on Venus.

  16. STRUCTURAL CALCULATION OF AN EMPLACEMENT PALLET STATICALLY LOADED BY A WASTE PACKAGE

    International Nuclear Information System (INIS)

    S. Mastilovic

    2000-01-01

    The purpose of this calculation is to determine the structural response of the emplacement pallet (EP) subjected to static load from the mounted waste package (WP). The scope of this document is limited to reporting the calculation results in terms of stress intensity magnitudes. This calculation is associated with the waste emplacement systems design; calculations are performed by the Waste Package Design group. AP-3.12Q, Revision 0, ICN 0, Calculations, is used to perform the calculation and develop the document. The finite element solutions are performed by using the commercially available ANSYS Version (V) 5.4 finite element code. The results of these calculations are provided in terms of maximum stress intensity magnitudes

  17. Thermal impact of waste emplacement and surface cooling associated with geologic disposal of nuclear waste

    International Nuclear Information System (INIS)

    Wang, J.S.Y.; Mangold, D.C.; Spencer, R.K.; Tsang, C.F.

    1982-01-01

    The age of nuclear waste - the length of time between its removal from the reactor cores and its emplacement in a repository - is a significant factor in determining the thermal loading of a repository. The surface cooling period as well as the density and sequence of waste emplacement affects both the near-field repository structure and the far-field geologic environment. To investigate these issues, a comprehensive review was made of the available literature pertaining to thermal effects and thermal properties of mined geologic repositories. This included a careful evaluation of the effects of different surface cooling periods of the wastes, which is important for understanding the optimal thermal loading of a repository. The results led to a clearer understanding of the importance of surface cooling in evaluating the overall thermal effects of a radioactive waste repository. The principal findings from these investigations are summarized in this paper

  18. Uncertainty and sensitivity results for pre-waste-emplacement groundwater travel time

    International Nuclear Information System (INIS)

    Kaplan, P.G.

    1992-01-01

    In this paper uncertainty and sensitivity analyses for pre-waste-emplacement groundwater travel time conducted. Although preliminary, a numbed of interesting results were obtained. Uncertainty in the ground water travel time statistics, as measured by the coefficient of variation, increases and then decrease as the modeled system transitions from matrix-dominated to fracture-dominated flow. The uncertainty analysis also suggests that the median, as opposed to the mean, may be a better indicator of performance with respect to the regulatory criterion. The sensitivity analysis shows a strong correlation between an effective fracture property, fracture porosity, and failure to meet the regulatory pre-waste-emplacement groundwater travel time criterion of 1,000 years

  19. Far-field thermomechanical response of argillaceous rock to emplacement of a nuclear-waste repository

    International Nuclear Information System (INIS)

    McVey, D.F.; Thomas, R.K.; Lappin, A.R.

    1980-08-01

    Before heat-producing wastes can be emplaced safely in any argillaceous rock, it will be necessary to understand the far-field thermal and thermomechanical response of this rock to waste emplacement. This report presents the results of a first series of calculations aimed at estimating the far-field response of argillite to waste emplacement. Because the thermal and mechanical properties of argillite are affected by its content of expandable clay, its behavior is briefly compared and contrasted with that of a shale having the same matrix thermal properties, but containing no expandable clay. Under this assumption, modeled temperatures are the same for the two rock types at equivalent power densities and reflect the large dependence of in-situ temperatures on both initial power density and waste type. Thermomechanical calculations indicate that inclusion of contraction behavior of expandable clays in the assumed argillite thermal expansion behavior results, in some cases, in generation of a large zone in and near the repository that has undergone volumetric contraction but is surrounded by uniformly compressive stresses. Information available to date indicates that this contraction would likely result in locally increased fluid permeability and decreased in-situ thermal conductivity, but might well be advantageous as regards radionuclide retention, because of the increased surface area within the contracted zone. Assumption of continuous and positive expansion behavior for the shale eliminates the near-repository contraction and tensional zones, but results in near-surface tensional zones directly above the repository

  20. The role of the geothermal gradient in the emplacement and replenishment of ground ice on Mars

    Science.gov (United States)

    Clifford, Stephen M.

    1993-01-01

    Knowledge of the mechanisms by which ground ice is emplaced, removed, and potentially replenished, are critical to understanding the climatic and hydrologic behavior of water on Mars, as well as the morphologic evolution of its surface. Because of the strong temperature dependence of the saturated vapor pressure of H2O, the atmospheric emplacement or replenishment of ground ice is prohibited below the depth at which crustal temperatures begin to monotonically increase due to geothermal heating. In contrast, the emplacement and replenishment of ground ice from reservoirs of H2O residing deep within the crust can occur by at least three different thermally-driven processes, involving all three phases of water. In this regard, Clifford has discussed how the presence of a geothermal gradient as small as 15 K/km can give rise to a corresponding vapor pressure gradient sufficient to drive the vertical transport of 1 km of water from a reservoir of ground water at depth to the base of the cryosphere every 10(exp 6) - 10(exp 7) years. This abstract expands on this earlier treatment by considering the influence of thermal gradients on the transport of H2O at temperatures below the freezing point.

  1. Postclosure performance assessment of the SCP [Site Characterization Plan] conceptual design for horizontal emplacement: Revision 1

    International Nuclear Information System (INIS)

    1987-08-01

    This report is a preliminary postclosure performance assessment of the repository design specified in the Site Characterization Plan Conceptual Design Report (SCP-CDR) for horizontal emplacement of high-level nuclear waste. At the time that these analyses were done, horizontal emplacement was the preferred orientation for the waste packages but vertical emplacement is now the reference design. This assessment consists of (1) a review of the regulatory requirements and strategy to demonstrate compliance with these requirements, (2) an analysis of the performance of the total repository system, (3) an analysis of the thermomechanical behavior of the repository, (4) an analysis of brine mobility in the repository, (5) an analysis of the waste package performance, (6) an analysis of the performance of seals, and (7) comments on the sensitivity of the various performance measures to uncertainties in the data and models. These are preliminary analyses and, in most cases, involve bounding calculations of the repository behavior. They have several purposes including (1) assessing how well this conceptual design ''measures up'' against requirements, (2) gaining experience in implementing the performance assessment strategy and tools and thereby learning where improvements are needed, (3) helping to identify needed data, and (4) helping to indicate required design modifications. 26 refs., 40 figs., 20 tabs

  2. Mechanical degradation of Emplacement Drifts at Yucca Mountain - A Modeling Case Study. Part I: Nonlithophysal Rock

    International Nuclear Information System (INIS)

    M. Lin; D. Kicker; B. Damjanac; M. Board; M. Karakouzian

    2006-01-01

    This paper outlines rock mechanics investigations associated with mechanical degradation of planned emplacement drifts at Yucca Mountain, which is the designated site for the proposed U.S. high-level nuclear waste repository. The factors leading to drift degradation include stresses from the overburden, stresses induced by the heat released from the emplaced waste, stresses due to seismically related ground motions, and time-dependent strength degradation. The welded tuff emplacement horizon consists of two groups of rock with distinct engineering properties: nonlithophysal units and lithophysal units, based on the relative proportion of lithophysal cavities. The term 'lithophysal' refers to hollow, bubble like cavities in volcanic rock that are surrounded by a porous rim formed by fine-grained alkali feldspar, quartz, and other minerals. Lithophysae are typically a few centimeters to a few decimeters in diameter. Part I of the paper concentrates on the generally hard, strong, and fractured nonlithophysal rock. The degradation behavior of the tunnels in the nonlithophysal rock is controlled by the occurrence of keyblocks. A statistically equivalent fracture model was generated based on extensive underground fracture mapping data from the Exploratory Studies Facility at Yucca Mountain. Three-dimensional distinct block analyses, generated with the fracture patterns randomly selected from the fracture model, were developed with the consideration of in situ, thermal, and seismic loads. In this study, field data, laboratory data, and numerical analyses are well integrated to provide a solution for the unique problem of modeling drift degradation

  3. Subsurface geology of a potential waste emplacement site, Salt Valley Anticline, Grand County, Utah

    Science.gov (United States)

    Hite, R.J.

    1977-01-01

    The Salt Valley anticline, which is located about 32 km northeast of Moab, Utah, is perhaps one of the most favorable waste emplacement sites in the Paradox basin. The site, which includes about 7.8 km 2, is highly accessible and is adjacent to a railroad. The anticline is one of a series of northwest-trending salt anticlines lying along the northeast edge of the Paradox basin. These anticlines are cored by evaporites of the Paradox Member of the Hermosa Formation of Middle Pennsylvanian age. The central core of the Salt Valley anticline forms a ridgelike mass of evaporites that has an estimated amplitude of 3,600 m. The evaporite core consists of about 87 percent halite rock, which includes some potash deposits; the remainder is black shale, silty dolomite, and anhydrite. The latter three lithologies are referred to as 'marker beds.' Using geophysical logs from drill holes on the anticline, it is possible to demonstrate that the marker beds are complexly folded and faulted. Available data concerning the geothermal gradient and heatflow at the site indicate that heat from emplaced wastes should be rapidly dissipated. Potentially exploitable resources of potash and petroleum are present at Salt Valley. Development of these resources may conflict with use of the site for waste emplacement.

  4. Subsurface geology of a potential waste emplacement site, Salt Valley Anticline, Grand County, Utah

    International Nuclear Information System (INIS)

    Hite, R.J.

    1977-01-01

    The Salt Valley anticline, which is located about 32 km northeast of Moab, Utah, is perhaps one of the most favorable waste emplacement sites in the Paradox basin. The site, which includes about 7.8 km 2 , is highly accessible and is adjacent to a railroad. The anticline is one of a series of northwest-trending salt antilcines lying along the northeast edge of the Paradox basin. These anticlines are cored by evaporites of the Paradox Member of the Hermosa Formation of Middle Pennsylvanian age. The central core of the Salt Valley anticline forms a ridgelike mass of evaporites that has an estimated amplitude of 3,600 m. The evaporite core consists of about 87 percent halite rock, which includes some potash deposits; the remainder is black shale, silty dolomite, and anhydrite. The latter three lithologies are referred to as ''marker beds.'' Using geophysical logs from drill holes on the anticline, it is possible to demonstrate that the marker beds are complexly folded and faulted. Available data concerning the geothermal gradient and heatflow at the site indicate that heat from emplaced wastes should be rapidly dissipated. Potentially exploitable resources of potash and petroleum are present at Salt Valley. Development of these resources may conflict with use of the site for waste emplacement

  5. Logistics Modeling of Emplacement Rate and Duration of Operations for Generic Geologic Repository Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Kalinina, Elena Arkadievna; Hardin, Ernest

    2015-11-01

    This study identified potential geologic repository concepts for disposal of spent nuclear fuel (SNF) and (2) evaluated the achievable repository waste emplacement rate and the time required to complete the disposal for these concepts. Total repository capacity is assumed to be approximately 140,000 MT of spent fuel. The results of this study provide an important input for the rough-order-of-magnitude (ROM) disposal cost analysis. The disposal concepts cover three major categories of host geologic media: crystalline or hard rock, salt, and argillaceous rock. Four waste package sizes are considered: 4PWR/9BWR; 12PWR/21BWR; 21PWR/44BWR, and dual purpose canisters (DPCs). The DPC concepts assume that the existing canisters will be sealed into disposal overpacks for direct disposal. Each concept assumes one of the following emplacement power limits for either emplacement or repository closure: 1.7 kW; 2.2 kW; 5.5 kW; 10 kW; 11.5 kW, and 18 kW.

  6. Logistics Modeling of Emplacement Rate and Duration of Operations for Generic Geologic Repository Concepts

    International Nuclear Information System (INIS)

    Kalinina, Elena Arkadievna; Hardin, Ernest

    2015-01-01

    This study identified potential geologic repository concepts for disposal of spent nuclear fuel (SNF) and (2) evaluated the achievable repository waste emplacement rate and the time required to complete the disposal for these concepts. Total repository capacity is assumed to be approximately 140,000 MT of spent fuel. The results of this study provide an important input for the rough-order-of-magnitude (ROM) disposal cost analysis. The disposal concepts cover three major categories of host geologic media: crystalline or hard rock, salt, and argillaceous rock. Four waste package sizes are considered: 4PWR/9BWR; 12PWR/21BWR; 21PWR/44BWR, and dual purpose canisters (DPCs). The DPC concepts assume that the existing canisters will be sealed into disposal overpacks for direct disposal. Each concept assumes one of the following emplacement power limits for either emplacement or repository closure: 1.7 kW; 2.2 kW; 5.5 kW; 10 kW; 11.5 kW, and 18 kW.

  7. The preparation and biological characterization of a new HL91-derivative for hypoxic imaging on stroke mice

    Energy Technology Data Exchange (ETDEWEB)

    Hsia, C.-C. [Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taiwan (China); Institute of Nuclear Energy Research, Taiwan (China); Huang, F.-L.; Lin, C.-H.; Shen, L.-H. [Institute of Nuclear Energy Research, Taiwan (China); Wang, H.-E., E-mail: hewang@ym.edu.t [Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taiwan (China)

    2010-09-15

    Aim: {sup 99m}Tc-HL91 (Prognox, GE-Healthcare) was the first nonnitro-aryl-based radiotracer for evaluating hypoxic fraction in neoplasm, stroke and myocardium infarction regions. However, the high hydrophilicity of {sup 99m}Tc-HL91 might hamper its penetration into cells. In this study, we prepared a new ligand 4,4,11,11-tetramethyl- 5,10-diazatetradecane- 3,12-dionedioxime (HL91-ET) with higher lipophilicity but structurally similar compared with that of HL91. The chemical and biological characterizations of {sup 99m}Tc-HL91-ET as a scintigraphic probe for hypoxia were performed with a stroke-bearing mouse model. Materials and Methods: HL91-ET was synthesized and formulated with stannous chloride and buffer to afford kits. After mixing with {sup 99m}Tc-pertechnetate, {sup 99m}Tc-HL91-ET can be prepared in high yield and high radiochemical purity (both >96%). The partition coefficient of {sup 99m}Tc-HL91-ET was determined in n-octanol/PBS system. Cellular uptake assays under normoxic and hypoxic conditions were performed in an oxygen-controlled CO{sub 2} incubator. Brain stroke in the mouse model was induced by the electrocautery of the middle cerebral artery. After intravenous injection of {sup 99m}Tc-HL91-ET into the Balb/c mouse suffering brain stroke, small-animal SPECT images were acquired at designated time points and autoradiography of the brain slides was conducted. Parallel studies of {sup 99m}Tc-HL91 were also conducted at the same conditions for comparison. Results: The higher partition coefficient of {sup 99m}Tc-HL91-ET (0.294{+-}0.007) indicated higher lipophlicity compared with that of {sup 99m}Tc-HL91 (0.089{+-}0.005). The {sup 99m}Tc-HL91-ET preparation was stable at ambient temperature for 24 h. Cellular uptake assay showed that {sup 99m}Tc-HL91-ET was less selectively retained in hypoxic cells than {sup 99m}Tc-HL91. The target-to-normal brain ratios derived from the autoradiograms of the brains of stroke mice were 1.31{+-}0.02 and 17

  8. The preparation and biological characterization of a new HL91-derivative for hypoxic imaging on stroke mice

    International Nuclear Information System (INIS)

    Hsia, C.-C.; Huang, F.-L.; Lin, C.-H.; Shen, L.-H.; Wang, H.-E.

    2010-01-01

    Aim: 99m Tc-HL91 (Prognox, GE-Healthcare) was the first nonnitro-aryl-based radiotracer for evaluating hypoxic fraction in neoplasm, stroke and myocardium infarction regions. However, the high hydrophilicity of 99m Tc-HL91 might hamper its penetration into cells. In this study, we prepared a new ligand 4,4,11,11-tetramethyl- 5,10-diazatetradecane- 3,12-dionedioxime (HL91-ET) with higher lipophilicity but structurally similar compared with that of HL91. The chemical and biological characterizations of 99m Tc-HL91-ET as a scintigraphic probe for hypoxia were performed with a stroke-bearing mouse model. Materials and Methods: HL91-ET was synthesized and formulated with stannous chloride and buffer to afford kits. After mixing with 99m Tc-pertechnetate, 99m Tc-HL91-ET can be prepared in high yield and high radiochemical purity (both >96%). The partition coefficient of 99m Tc-HL91-ET was determined in n-octanol/PBS system. Cellular uptake assays under normoxic and hypoxic conditions were performed in an oxygen-controlled CO 2 incubator. Brain stroke in the mouse model was induced by the electrocautery of the middle cerebral artery. After intravenous injection of 99m Tc-HL91-ET into the Balb/c mouse suffering brain stroke, small-animal SPECT images were acquired at designated time points and autoradiography of the brain slides was conducted. Parallel studies of 99m Tc-HL91 were also conducted at the same conditions for comparison. Results: The higher partition coefficient of 99m Tc-HL91-ET (0.294±0.007) indicated higher lipophlicity compared with that of 99m Tc-HL91 (0.089±0.005). The 99m Tc-HL91-ET preparation was stable at ambient temperature for 24 h. Cellular uptake assay showed that 99m Tc-HL91-ET was less selectively retained in hypoxic cells than 99m Tc-HL91. The target-to-normal brain ratios derived from the autoradiograms of the brains of stroke mice were 1.31±0.02 and 17.47±0.10 (n=3), respectively, at 2 h post injection of 99m Tc-HL91-ET and 99m Tc-HL91

  9. The CMS ECAL Upgrade for Precision Crystal Calorimetry at the HL-LHC

    CERN Document Server

    Jofrehei, Arash

    2017-01-01

    The Compact Muon Solenoid Experiment (CMS) is operating at the Large Hadron Collider (LHC) with proton-proton collisions at 13 TeV center-of-mass energy and at a bunch spacing of 25 ns. Challenging running conditions for CMS are expected after the High-Luminosity upgrade of the LHC (HL-LHC). We review the CMS ECAL crystal calorimeter upgrade and present results from the first test beam studies. Particular challenges at HL-LHC are the harsh radiation environment, the increasing data rates and the extreme level of pile-up events, with up to 200 simultaneous proton-proton collisions. Precision timing can be exploited to reduce the effect of the pile-up. We report on the timing resolution studies performed with test-beams. We discuss the new readout and trigger electronics, which must be upgraded due to the increased trigger and latency requirements at the HL-LHC.

  10. Concept design for the central control system of HL-2A

    International Nuclear Information System (INIS)

    Song Xianming; Li Qiang; Jiang Chao

    2001-01-01

    The design principle and basic structure of the central control system for HL-2A Tokamak are introduced. Having been limited by manpower and money, the central control system should not be too expensive and too advanced. On the other hand, because of the complexity of the machine and the difficulty the author will encounter when operating the machine, the central control system should be advanced enough. If use the same technology for HL-1M to control HL-2A, the author would fail to fulfill authors' experiment goal. The central control system consists of software and hardware. The software mainly includes: (a) system monitor and control software; (b) discharge monitor and control software; (c) network and communication software. Hardware includes: (a) PLC for machine control, personnel protection and machine protection; and (b) VME computer, for the feedback control of the discharge

  11. Ageing studies of resistive Micromegas detectors for the HL-LHC

    CERN Document Server

    Galán, J; Ferrer-Ribas, E; Giganon, A; Giomataris, I; Herlant, S; Jeanneau, F; Peyaud, A; Schune, Ph; Alexopoulos, T; Byszewski, M; Iakovidis, G; Iengo, P; Ntekas, K; Leontsinis, S; de Oliveira, R; Tsipolitis, Y; Wotschack, J

    2013-01-01

    Resistive-anode Micromegas detectors are in development since several years, in an effort to solve the problem of sparks when working in high flux and high radiations environment like in the HL-LHC (ten times the luminosity of the LHC). They have been chosen as one of the technologies that will be part of the ATLAS New Small Wheel project (forward muon system). An ageing study is mandatory to assess their capabilities to handle the HL-LHC environment on a long-term period. A prototype has been exposed to several types of irradiations (X-rays, cold neutrons, 60 Co gammas) up to an equivalent HL-LHC time of more than five years without showing any degradation of the performances in terms of gain and energy resolution. Beam test studies took place in October 2012 to assess the tracking performances (efficiency, spatial resolution,...). Results of ageing studies and beam test performances are reported in this paper.

  12. Simulation of the MHD stabilities of the experiment on HL-2A tokamak by GATO code

    International Nuclear Information System (INIS)

    Pan Wei; Chen Liaoyuan; Dong Jiaqi; Shen Yong; Zhang Jinhua

    2009-01-01

    The ideal two-dimensional MHD stabilities code, GATO, has been successfully immigrated to the high-performance computing system of HL-2A and used to the simulation study of the ideal MHD stabilities of the plasmas produced by one of the pellets injection experiments on HL-2A tokamak. The EFIT code was used to reconstruct the equilibrium configures firstly and the GATO was used to compute their MHD stabilities secondly whose source data were obtained by the NO.4050 discharge of the experiments on HL-2A, and finally by analyzing these results the preliminary conclusion was devised that the confinement performance of the plasma was improved because of the stabilization effect of the anti-sheared configures created by the pellets injection. (authors)

  13. H-L transition caused by irregular probe insertion in the JFT-2M tokamak

    International Nuclear Information System (INIS)

    Hanada, K.; Hasegawa, M.; Shinohara, K.

    1996-01-01

    A pair of probe pins whose lengths differ by 5 mm are inserted into the separatrix of H-mode plasmas. When the long pin is biased positively against the short one, the H-L transition takes place and the current through the resistor making a connection between these pins increases for 10 μs and the potential of the pin increases for 100 μs. The energy dissipated by the resistor during the H-L transition is comparable to the energy of the radial electric field in H-mode plasma. When the long pin is biased negatively, the H-L transition also occurs; however, it takes 1 ms to change the potential of the pin and the plasma returns to H-mode after the extraction of the probe. (author)

  14. Rare Coumarins Induce Apoptosis, G1 Cell Block and Reduce RNA Content in HL60 Cells

    Directory of Open Access Journals (Sweden)

    Widelski Jarosław

    2017-02-01

    Full Text Available The rare coumarins stenocarpin, stenocarpin isobutyrate, oficinalin, oficinalin isobutyrate, 8-methoxypeucedanin and the known xanthotoxin, isoimperatorin, bergapten, peucedanin and 8–methoxyisoimperatorin were isolated from Peucedanum luxurians Tamamsch. (Apiaceae and identified by means of spectral data (1D and 2D NMR. Their immunomodulating activity was evaluated by flow cytometry and their influence on HL60 cells as well as on PHA-stimulated PBLs was tested. All tested coumarins induce apoptosis (maximal in the 48 h culture and decrease cell proliferation in a time- and dose-dependent manner, especially in HL60 cells. They also induce partial G1 block, but only in HL60 cells (at 100 µM concentrations. Dose-dependent reduction of RNA content was also found in G1 cells treated by the coumarins. All of the tested coumarins also possessed immunomodulatory activities. Bergapten and xanthotoxin were found to be the best candidates for further evaluation as anti-cancer drugs.

  15. [Biologically active fragment of the differentiation factor from HL-60 cell line. Identification and properties].

    Science.gov (United States)

    Kostanian, I A; Astapova, M V; Navolotskaia, E V; Lepikhova, T N; Dranitsyna, S M; Telegin, G B; Rodionov, I L; Baĭdakova, L K; Zolotarev, Iu A; Molotkovskaia, I M; Lipkin, V M

    2000-07-01

    Six-membered peptide fragment TGENHR (HLDF-6) was identified in the HL-60 cell culture of human promyelocyte leukemia treated with retinoic acid when studying the differentiation factor HLDF of this cell line. HLDF-6 retains the ability of the full-size factor to induce the differentiation and arrest the proliferation of the starting HL-60 cells. It was shown that the synthetic peptide HLDF-6 has no specific receptors on the surface of the HL-60 cells but can affect the binding of interleukin IL-1 beta, a cytokine involved in proliferation, to the cell surface. It was found on a model of transplantable NSO myeloma that HLDF-6 has an antitumor activity.

  16. Optics of ion beams for the neutral beam injection system on HL-2A Tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Zou, G. Q.; Lei, G. J.; Cao, J. Y.; Duan, X. R. [Southwestern Institute of Physics, Chengdu, 610041 (China)

    2012-07-15

    The ion beam optics for the neutral beam injection system on HL-2A Tokomak is studied by two- dimensional numerical simulation program firstly, where the emitting surface is taken at 100 Debye lengths from the plasma electrode. The mathematical formulation, computation techniques are described. Typical ion orbits, equipotential contours, and emittance diagram are shown. For a fixed geometry electrode, the effect of plasma density, plasma potential and plasma electron temperature on ion beam optics is examined, and the calculation reliability is confirmed by experimental results. In order to improve ion beam optics, the application of a small pre-acceleration voltage ({approx}100 V) between the plasma electrode and the arc discharge anode is reasonable, and a lower plasma electron temperature is desired. The results allow optimization of the ion beam optics in the neutral beam injection system on HL-2A Tokomak and provide guidelines for designing future neutral beam injection system on HL-2M Tokomak.

  17. Optics of ion beams for the neutral beam injection system on HL-2A Tokamak.

    Science.gov (United States)

    Zou, G Q; Lei, G J; Cao, J Y; Duan, X R

    2012-07-01

    The ion beam optics for the neutral beam injection system on HL-2A Tokomak is studied by two- dimensional numerical simulation program firstly, where the emitting surface is taken at 100 Debye lengths from the plasma electrode. The mathematical formulation, computation techniques are described. Typical ion orbits, equipotential contours, and emittance diagram are shown. For a fixed geometry electrode, the effect of plasma density, plasma potential and plasma electron temperature on ion beam optics is examined, and the calculation reliability is confirmed by experimental results. In order to improve ion beam optics, the application of a small pre-acceleration voltage (∼100 V) between the plasma electrode and the arc discharge anode is reasonable, and a lower plasma electron temperature is desired. The results allow optimization of the ion beam optics in the neutral beam injection system on HL-2A Tokomak and provide guidelines for designing future neutral beam injection system on HL-2M Tokomak.

  18. Plasma electron density measurement with multichannel microwave interferometer on the HL-1 tokamak device

    International Nuclear Information System (INIS)

    Xu Deming; Zhang Hongyin; Liu Zetian; Ding Xuantong; Li Qirui; Wen Yangxi

    1989-11-01

    A multichannel microwave interferometer which is composed of different microwave interferometers (one 2 mm band, one 4 mm band and two 8 mm band) has been used to measure the plasma electron density on HL-1 tokamak device. The electron density approaching to 5 x 10 13 cm -3 is measured by a 2 mm band microwave interferometer. In the determinable range, the electron density profile in the cross-section on HL-1 device has been measured by this interferometer. A microcomputer data processing system is also developed

  19. Multi-channel time-division integrator in HL-2A

    International Nuclear Information System (INIS)

    Yan Ji

    2008-01-01

    HL-2A is China's first Tokamak device with divertor configuration (magnetic confinement controlled nuclear fusion device). To find out the details of on-going fusion reaction at different times is of important significance in achieving controlled nuclear fusion. We developed a new type multi-channel time-division integrator for HL-2A. It has functions of automatic cutting off negative pulse of the input signals, optional integrating time division spacing 0.2-1 ms, TTL starting trigger signal, automatic regularly work 20 s, and integrating 10 channel at the same time. (authors)

  20. Prevalence, birth incidence, and penetrance of von Hippel-Lindau disease (vHL) in Denmark

    DEFF Research Database (Denmark)

    Binderup, Marie Louise Mølgaard; Galanakis, Michael Carter Bisgaard; Budtz-Jørgensen, Esben

    2017-01-01

    the international diagnostic criteria. We found an overall penetrance of 87% at age 60 years. When considering only vHL patients who have not attended surveillance, 20% will still be asymptomatic at age 60 years. This should be considered in the context of genetic counselling, especially when assessing the risk...... of vHL in asymptomatic adult first-degree relatives who are often not genetically tested.European Journal of Human Genetics advance online publication, 14 December 2016; doi:10.1038/ejhg.2016.173....

  1. Beam Cleaning in Experimental IRs in HL-LHC for the Incoming Beam

    CERN Document Server

    Garcia-Morales, H; Bruce, Roderik; Redaelli, Stefano

    2015-01-01

    The HL-LHC will store 675 MJ of energy per beam, about 300 MJ more than the nominal LHC. Due to the increase in stored energy and a different interaction region (IR) optics layout, the collimation system for the incoming beam must be revisited in order to avoid dangerous losses that could cause quenches or machine damage. This paper studies the effectiveness of the current LHC collimation system in intercepting cleaning losses close to the experiments in the HL-LHC. The study reveals that additional tertiary collimators would be beneficial in order to protect not only the final focusing triplets but also the two quadrupoles further upstream.

  2. Performances and ageing study of resistive-anodes Micromegas detectors for HL-LHC environment

    CERN Document Server

    Jeanneau, F; Attié, D; Boyer, M; Derré, J; Fanourakis, G; Ferrer-Ribas, E; Galán, J; Gazis, E; Geralis, T; Giganon, A; Giomataris, I; Herlant, S; Manjarrés, J; Ntomari, E; Schune, Ph; Titov, M; Tsipolitis, G

    2012-01-01

    With the tenfold luminosity increase envisaged at the HL-LHC, the background (photons, neutrons, ...) and the event pile-up probability are expected to increase in proportion in the different experiments, especially in the forward regions like, for instance, the muons chambers of the ATLAS detector. Detectors based on the Micromegas principle should be good alternatives for the detector upgrade in the HL-LHC framework because of a good spatial ( 98%) can be achieved with resistive-anode micromegas detector. An X-rays irradiation has been also performed, showing no ageing effect after more than 21 days exposure and an integrated charge of almost 1C.

  3. Beam cleaning of the incoming beam in experimental IRs in HL-LHC

    CERN Document Server

    Garcia Morales, Hector; Redaelli, Stefano; De Maria, Riccardo; CERN. Geneva. ATS Department

    2017-01-01

    The HL-LHC will store 675 MJ of energy per beam, about 300 MJ more than the nominal LHC. Due to the increase in stored energy and a different interaction region (IR) layout and optics design, the collimation system for the incoming beam must be revisited in order to avoid dangerous losses that could cause quenches and machine damage. This paper studies the effectiveness of the current LHC collimation system in intercepting cleaning losses close to the experiments in the HL-LHC. The study reveals that in addition to the triplet also the Q4 needs local protection, which could be provided by an additional pair of TCTs.

  4. Power supply for plasma generator of HL-1M neutral beam injector

    International Nuclear Information System (INIS)

    Wang Detai; Qian Jiamei; Lei Guangjiu; Shun Mengda; Jiang Shaofeng; Wang Enyao; Lu Xuejun; Yang Tiehai; Wang Xuehua; Zhao Zhimin; Hao Ming; Huang Jianrong; Yu Yanqiu; Cheng Baoqiang; Wu Zhige; Sheng Ning; Hu Qingtao

    1999-01-01

    The diagram of the HL-1M Neutral Beam Injector (NBI) and the power supply (PS) system is shown. The NBI consists of ion source, beam line and power supply system etc. The ion source includes plasma generator and three-electrode extraction system. The power supply for plasma generator consists of a filament PS, an arc PS and gas valve PS. Testing has shown that the PS for plasma generator of the HL-1M NBI has excellent stability and obtain good plasma heating effect

  5. Hollow Electron Beam Collimation for HL-LHC - Effects on the Beam Core

    Energy Technology Data Exchange (ETDEWEB)

    Fitterer, M. [Fermilab; Stancari, G. [Fermilab; Valishev, A. [Fermilab; Bruce, R. [CERN; Papotti, G [CERN; Redaelli, S. [CERN; Valentino, G. [Malta U.; Valentino, G. [CERN; Valuch, D. [CERN; Xu, C. [CERN

    2017-06-13

    Collimation with hollow electron beams is currently one of the most promising concepts for active halo control in the High Luminosity Large Hadron Collider (HL-LHC). To ensure the successful operation of the hollow beam collimator the unwanted effects on the beam core, which might arise from the operation with a pulsed electron beam, must be minimized. This paper gives a summary of the effect of hollow electron lenses on the beam core in terms of sources, provides estimates for HL-LHC and discusses the possible mitigation methods.

  6. Retrieval system for emplaced spent unreprocessed fuel (SURF) in salt bed depository. Baseline concept criteria specifications and mechanical failure probabilities

    International Nuclear Information System (INIS)

    Hudson, E.E.; McCleery, J.E.

    1979-05-01

    One of the integral elements of the Nuclear Waste Management Program is the material handling task of retrieving Canisters containing spent unreprocessed fuel from their emplacement in a deep geologic salt bed Depository. A study of the retrieval concept data base predicated this report. In this report, alternative concepts for the tasks are illustrated and critiqued, a baseline concept in scenario form is derived and basic retrieval subsystem specifications are presented with cyclic failure probabilities predicted. The report is based on the following assumptions: (a) during retrieval, a temporary radiation seal is placed over each Canister emplacement; (b) a sleeve, surrounding the Canister, was initially installed during the original emplacement; (c) the emplacement room's physical and environmental conditions established in this report are maintained while the task is performed

  7. Thermal modeling of pluton emplacement and associated contact metamorphism:Parashi stock emplacement in the Serranía de Jarara (Alta Guajira, Colombia

    Directory of Open Access Journals (Sweden)

    Zuluaga C. Carlos A.

    2010-12-01

    Full Text Available

    In the northernmost portion of the Serrania de Jarara (Alta Guajira, Colombia, low - medium grade metamorphic rocks from the Etpana Metamorphic Suite were thermally affected by emplacement of a small calc-alkaline intrusion (Parashi Stock. Detailed petrographic analysis in collected rock samples across the NE and NW plutonic contacts show occurrences of textural and mineralogical changes in the country rock fabric that evidence contact metamorphism overprinting regional metamorphism of the Etpana Suite. These changes include growth of andalusite (chiastolite, calcic clinopyroxeneand amphibole porphyroblast crosscutting Sn+1 metamorphicfoliation. Hornblende-plagioclase barometry (ca. 3.1 kbar and cooling models for the stock show maximum time temperature evolution in the country rock at the interpreted depth of intrusion (ca. 11 km and help to evaluate the behavior of the country rock with the changing local geotherm.

  8. Iron Phosphate Glass for Vitrifying Hanford AZ102 LAW in Joule Heated and Cold Crucible Induction Melters - 12240

    Energy Technology Data Exchange (ETDEWEB)

    Day, Delbert E.; Brow, Richard K.; Ray, Chandra S.; Reis, Signo T. [Missouri University of Science and Technology, 1870 Miner Circle, Rolla, MO 65409 (United States); Kim, Cheol-Woon [MO-SCI Corporation, 4040 HyPoint North, Rolla, MO 65401 (United States); Vienna, John D.; Sevigny, Gary [Pacific North West National Laboratory, Battelle Blvd., Richland, WA 99352 (United States); Peeler, David; Johnson, Fabienne C.; Hansen, Eric K. [Savannah River National Laboratory, Savannah River Site, 999-W, Aiken, SC 29803 (United States); Soelberg, Nick [Idaho National Laboratory, 2525 Fremont Avenue, Idaho Falls, ID 83415 (United States); Pegg, Ian L.; Gan, Hao [Catholic University of America, 620 Michigan Avenue, N.E., Washington, DC 20064 (United States)

    2012-07-01

    An iron phosphate composition for vitrifying a high sulfate (∼17 wt%) and high alkali (∼80 wt%) Hanford low activity waste (LAW), known as AZ-102 LAW, has been developed for processing in a Joule Heated Melter (JHM) or a Cold Crucible Induction Melter (CCIM). This composition produced a glass waste form, designated as MS26AZ102F-2, with a waste loading of 26 wt% of the AZ-102 which corresponded to a total alkali and sulfate (represented as SO{sub 3}) content of 21 and 4.4 wt%, respectively. A slurry (7 M Na{sup +}) of MS26AZ102F-2 simulant was melted continuously at temperatures between 1030 and 1090 deg. C for 10 days in a small JHM at PNNL and for 70 hours in a CCIM at INL. The as-cast glasses produced in both melters and in trial laboratory experiments along with their canister centerline cooled (CCC) counterparts met the requirements for the Product Consistency Test (PCT) and the Vapor Hydration Test (VHT) responses in the Hanford Tank Waste Treatment and Immobilization Plant (WTP) Contract. These glass waste forms retained up to 77 % of the SO{sub 3} (3.3 wt%), 100% of the Cesium, and 33 to 44% of the rhenium (used as a surrogate for Tc) all of which either exceeded or were comparable to the retention limit for these species in borosilicate glass nuclear waste form. Analyses of commercial K-3 refractory lining and the Inconel 693 metal electrodes used in JHM indicated only minimum corrosion of these components by the iron phosphate glass. This is the first time that an iron phosphate composition was melted continuously in a slurry fed JHM and in the US, thereby, demonstrating that iron phosphate glasses can be used as alternative hosts for vitrifying nuclear waste. The following conclusions are drawn from the results of the present work. (1) An iron phosphate composition, designated as MS26AZ102F-2, containing 26 wt% of the simulated high sulfate (17 wt%), high alkali (80 wt%) Hanford AZ-102 LAW meets all the criteria for processing in a JHM and CCIM. This

  9. NLS-RARα promotes proliferation and inhibits differentiation in HL-60 cells.

    Science.gov (United States)

    Hu, Xiu-Xiu; Zhong, Liang; Zhang, Xi; Gao, Yuan-Mei; Liu, Bei-Zhong

    2014-01-01

    A unique mRNA produced in leukemic cells from a t(15;17) acute promyelocytic leukemia (APL) patient encodes a fusion protein between the retinoic acid receptor α (RARα) and a myeloid gene product called PML. Studies have reported that neutrophil elastase (NE) cleaves bcr-1-derived PML-RARα in early myeloid cells, leaving only the nuclear localization signal (NLS) of PML attached to RARα. The resultant NLS-RARα fusion protein mainly localizes to, and functions within, the cell nucleus. It is speculated that NLS-RARα may act in different ways from the wild-type RARα, but its biological characteristics have not been reported. This study takes two approaches. Firstly, the NLS-RARα was silenced with pNLS-RARα-shRNA. The mRNA and protein expression of NLS-RARα were detected by RT-PCR and Western blot respectively. Cell proliferation in vitro was assessed by MTT assay. Flow cytometry (FCM) was used to detect the differentiation of cells. Secondly, the NLS-RARα was over-expressed by preparation of recombinant adenovirus HL-60/pAd-NLS-RARα. The assays of mRNA and protein expression of NLS-RARα, and cell proliferation, were as above. By contrast, cell differentiation was stimulated by all trans retinoic acid (ATRA) (2.5µmol/L) at 24h after virus infection of pAd-NLS-RARα, and then detected by CD11b labeling two days later. The transcription and translation of C-MYC was detected in HL-60/pAd-NLS-RARα cells which treated by ATRA. Our results showed that compared to the control groups, the expression of NLS-RARα was significantly reduced in the HL-60/pNLS-RARα-shRNA cells, and increased dramatically in the HL-60/pAd-NLS-RARα cells. The proliferation was remarkably inhibited in the HL-60/pNLS-RARα-shRNA cells in a time-dependent manner, but markedly promoted in the HL-60/pAd-NLS-RARα cells. FCM outcome revealed the differentiation increased in HL-60/pNLS-RARα-shRNA cells, and decreased in the HL-60/pAd-NLS-RARα cells treated with 2.5µmol/L ATRA. The

  10. Coldbox installation for HL-LHC crab cavity test in the SPS tunnel (BA6)

    CERN Document Server

    Ordan, Julien Marius

    2018-01-01

    The Cold-box, produced by Linde Kryotechnik for the SPS crab-cavity test stand for HL-LHC, on its arrival at CERN. It wll be transported into the tunnel in horizontal position and then will have to be tilted in its operational position, on its vertical axis, before connecting it to cryogenics lines.

  11. Radiation hard silicon particle detectors for HL-LHC—RD50 status report

    Energy Technology Data Exchange (ETDEWEB)

    Terzo, S., E-mail: Stefano.Terzo@mpp.mpg.de

    2017-02-11

    It is foreseen to significantly increase the luminosity of the LHC by upgrading towards the HL-LHC (High Luminosity LHC). The Phase-II-Upgrade scheduled for 2024 will mean unprecedented radiation levels, way beyond the limits of the silicon trackers currently employed. All-silicon central trackers are being studied in ATLAS, CMS and LHCb, with extremely radiation hard silicon sensors to be employed on the innermost layers. Within the RD50 Collaboration, a massive R&D program is underway across experimental boundaries to develop silicon sensors with sufficient radiation tolerance. We will present results of several detector technologies and silicon materials at radiation levels corresponding to HL-LHC fluences. Based on these results, we will give recommendations for the silicon detectors to be used at the different radii of tracking systems in the LHC detector upgrades. In order to complement the measurements, we also perform detailed simulation studies of the sensors. - Highlights: • The RD50 collaboration investigates the radiation hardness of silicon sensors. • Different approaches to simulate the detector response after irradiation are shown. • HV-CMOS are cost-effective solution for the outer pixel layers at HL-LHC. • 3D and thin planar sensors with slim edges are solutions for innermost layers at HL-LHC. • Sensors with intrinsic gain are investigated to develop ultra-fast silicon detectors.

  12. The CMS ECAL Upgrade for Precision Crystal Calorimetry at the HL-LHC

    CERN Document Server

    Petyt, David Anthony

    2018-01-01

    The electromagnetic calorimeter (ECAL) of the Compact Muon Solenoid Experiment (CMS) is operating at the Large Hadron Collider (LHC) in 2016 with proton-proton collisions at 13 TeV center-of-mass energy and at a bunch spacing of 25 ns. Challenging running conditions for CMS are expected after the High-Luminosity upgrade of the LHC (HL-LHC). We review the design and R and D studies for the CMS ECAL crystal calorimeter upgrade and present first test beam studies. Particular challenges at HL-LHC are the harsh radiation environment, the increasing data rates and the extreme level of pile-up events, with up to 200 simultaneous proton-proton collisions. We present test beam results of hadron irradiated PbWO$_{4}$ crystals up to fluences expected at the HL-LHC. We also report on the R and D for the new readout and trigger electronics, which must be upgraded due to the increased trigger and latency requirements at the HL-LHC.

  13. Design for the excitation systems of three generator sets of HL-2A

    International Nuclear Information System (INIS)

    Li Huajun; Xu Lirong; Liu Xuemei; You Tianxue

    2001-01-01

    The design for the excitation systems have been made on the basis of respective features and load demands of three motor-generator sets of HL-2A. The excitation systems of No.1 and No.2 generator sets which supply for toroidal field are discussed in detail and three feasible excitation plans have been proposed according to the investment

  14. HL-LHC and HE-LHC Upgrade Plans and Opportunities for US Participation

    Science.gov (United States)

    Apollinari, Giorgio

    2017-01-01

    The US HEP community has identified the exploitation of physics opportunities at the High Luminosity-LHC (HL-LHC) as the highest near-term priority. Thanks to multi-year R&D programs, US National Laboratories and Universities have taken the leadership in the development of technical solutions to increase the LHC luminosity, enabling the HL-LHC Project and uniquely positioning this country to make critical contributions to the LHC luminosity upgrade. This talk will describe the shaping of the US Program to contribute in the next decade to HL-LHC through newly developed technologies such as Nb3Sn focusing magnets or superconducting crab cavities. The experience gained through the execution of the HL-LHC Project in the US will constitute a pool of knowledge and capabilities allowing further developments in the future. Opportunities for US participations in proposed hadron colliders, such as a possible High Energy-LHC (HE-LHC), will be described as well.

  15. Identification of chimpanzee leukocyte antigens (ChL-A) and their relation to HL-A

    NARCIS (Netherlands)

    Balner, H.

    1971-01-01

    The identification of a number of leukocyte antigens of chimpanzees is described. Suggestive evidence was obtained that some of the isoantisera recognize specificities of a hypothetical genetic system of chimpanzee antigens which, in analogy with the human HL-A system, is tentatively called ChL-A.

  16. Mapping HL7 CDA R2 Formatted Mass Screening Data to OpenEHR Archetypes.

    Science.gov (United States)

    Kobayashi, Shinji; Kume, Naoto; Yoshihara, Hiroyuki

    2017-01-01

    Mass screening of adults was performed to manage employee healthcare. The screening service defined the data collection format as HL7 Clinical Document Architecture (CDA) R2. To capture mass screening data for nationwide electronic health records (her), we programmed a model within the CDA format and mapped the data items to the ISO13606/openEHR archetype for semantic interoperabiilty.

  17. Characterized the pattern of the material deposition in the HL-2A tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Laizhong, E-mail: cailz@swip.ac.cn [Southwestern Institute of Physics, P.O.Box 432, Chengdu, Sichuan 610041 (China); Wang, Jianbao; Wu, Ting; Zeng, Xiaoxiao [Southwestern Institute of Physics, P.O.Box 432, Chengdu, Sichuan 610041 (China); Hai, Ran; Ding, Hongbin [Dalian University of Technology, Dalian, Liaoning 116024 (China)

    2017-03-15

    Since the divertor geometry of a tokamak has a strong impact on the material erosion and deposition on the wall and HL-2A has a unique divertor configuration, it is necessary to investigate the material deposition pattern in HL-2A although a few results on other tokamaks have already been published. In this paper, tiles retrieved from the vessel are analyzed ex-situ by SIMS, SEM and laser-induced breakdown spectroscopy (LIBS). And deposition behind the lower divertor is in-situ measured by a quartz crystal microbalance (QMB). The deposition in HL-2A displays a complex pattern and clear localization characteristic. The thickness of the deposition layer varies in the range of 0-4μm. And in-situ diagnostic of QMB indicates that the average thickness of the deposition layer per pulse is over ten nanometers. In addition, the results imply that Si, Fe and D have different behaviors during the material deposition in HL-2A.

  18. Design and fabrication of the NASA HL-20 support cradle and interior mockup

    Science.gov (United States)

    Exum, Thurman

    1991-01-01

    An extensive test program involving analysis in both the horizontal and vertical attitudes of the HL-20 will be conducted by NASA-Langley. This necessitated the fabrication of a steel support cradle for the composite Personnel Launch System (PLS) model and an internal mockup to simulate the pilot and passenger compartments.

  19. Localizing the HL7 Personal Health Monitoring Record for Danish Telemedicine

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak

    2014-01-01

    Telemedicine holds a promise of lowering cost in health care and improving the life quality of chronic ill patients by allowing monitoring in the home. The Personal Health Monitoring Record (PHMR) is an international HL7 standard data format for encoding measurements made by devices in the home...

  20. Analysis of the plasma magnetohydrodynamic equilibrium in iron core transformer Tokamak HL-1M

    International Nuclear Information System (INIS)

    Chen Xiaoguang; Yuan Baoshan

    1992-01-01

    The physical and mathematical model are presented on the problem of MHD equilibrium with the self consistent in iron core transformer HL-1M. Calculation and analysis for the plasma equilibrium of the stable boundary and free boundary are shown respectively, in an axisymmetric equilibrium model of two dimensions. First, a variation formulation of the problem is written and the equations of the poloided flux ψ are solved by a finite element method; the Picard and Newton algorithms are tested for the non-linearities. The plasma boundary and the magnetic surfaces are being simulated, with the currents in the coils, the total plasma current, its current density function and the magnetic permeability of the iron being the data for the problem; a certain number of the characteristic parameter of the equilibrium configuration is calculated. Secondly, a simple method of calculation is adopted in the determination of equilibrium fields and currents in iron core HL-1M tokamak device. In the plasma equilibrium, the magnetic effect of the air gaps in the iron core and the iron magnetic shielded plate are considered in HL-1M device. Reliable data are provided for designing and constructing the poloidal field system of HL-1M device. A good computer code is constructed, which may be useful in operating on analysis for the future device

  1. Numerical simulation of MHD equilibrium configuration for the HL-2A modification

    International Nuclear Information System (INIS)

    Chen Qian; Wang Aike; Li Fangzhu; Zhang Jinghua

    2008-01-01

    Numerical simulation is employed for the HL-2A modification, which includes the optimum design of zero-field in the start-up phase, the limiter equilibrium configuration, the single/double null divertor equilibrium configuration, and the equilibrium configuration evolution from gas breakdown to current plateau. Results show that the new program can satisfy the design requirement. (authors)

  2. Fragmentation process of vitrified ceramic waste (VCW) aiming its incorporation in silico-aluminous refractory concrete for production of refractory bricks

    International Nuclear Information System (INIS)

    Gomes, L.B.; Brandalise, R.N.; Santos, V. dos; Bergmann, C.P.

    2012-01-01

    Ceramic industry generates large amounts of waste, usually disposed in landfills. Reuse could minimize their generation and provides sustainable solutions. However, the energy cost of grinding these waste becomes a hindrance to their reuse. This work aims to obtain particle sizes of vitrified ceramic waste (VCW) using a fast, efficient and low cost fragmentation process as well as its use in refractory concrete. The results shows a wide range of particle size of VCW, which can be used as a promising source of raw material for production of refractory concrete. (author)

  3. Analysis of surface leaching processes in vitrified high-level nuclear wastes using in-situ raman imaging and atomistic modeling. 1998 annual progress report

    International Nuclear Information System (INIS)

    Clark, D.E.; Simmons, J.H.

    1998-01-01

    'The research objective was to test and develop optical methods for real-time, remote and in-situ testing of corrosion processes on the surface of vitrified nuclear wastes. This report summarizes the research conducted in the first 1.5 years of a 3 year grant. At this point, the authors have identified the conditions for optimal tests and demonstrated that both IR reflection and Raman spectroscopies can be used to determine the dealkalization process in the surface of simple glasses in real time.'

  4. A review and analysis of European industrial experience in handling LWR [light water reactor] spent fuel and vitrified high-level waste

    International Nuclear Information System (INIS)

    Blomeke, J.O.

    1988-06-01

    The industrial facilities that have been built or are under construction in France, the United Kingdom, Sweden, and West Germany to handle light-water reactor (LWR) spent fuel and canisters of vitrified high-level waste before ultimate disposal are described and illustrated with drawings and photographs. Published information on the operating performances of these facilities is also given. This information was assembled for consideration in planning and design of similar equipment and facilities needed for the Federal Waste Management System in the United States. 79 refs., 71 figs., 10 tabs

  5. The Hellenic National Tsunami Warning Centre (HL-NTWC): Recent updates and future developments

    Science.gov (United States)

    Melis, Nikolaos S.; Charalampakis, Marinos

    2014-05-01

    The Hellenic NTWC (HL-NTWC) was established officially by Greek Law in September 2010. HL-NTWC is hosted at the National Observatory of Athens, Institute of Geodynamics (NOA-IG), which also operates a 24/7 earthquake monitoring service in Greece and coordinates the newly established Hellenic Unified National Seismic Network. NOA-IG and HL-NTWC Operational Centre is linked to the Civil Protection Operational Centre and serves as the official alerting agency to the General Secretariat for Civil Protection in Greece, regarding earthquake events and tsunami watch. Since August 2012, HL-NTWC acts as Candidate Tsunami Watch Provider (CTWP) under the UNESCO IOC - ICG NEAMTWS tsunami warning system (NEAM: North-Eastern Atlantic, the Mediterranean and connected seas) and offers its services to the NEAMTWS system. HL-NTWC has participated in all Communication Test Exercises (CTE) under NEAMTWS and also it has provided tsunami scenarios for extended system testing exercises such as NEAMWAVE12. Some of the recent developments at HL-NTWC in Greece include: deployment of new tide gauge stations for tsunami watch purposes, computation of tsunami scenarios and extending the database in use, improving alerting response times, earthquake magnitude estimation and testing newly established software modules for tsunami and earthquake alerting (i.e. Early-Est, SeisComP3 etc.) in Greece and the Eastern Mediterranean. Although funding today is limited, an advantage of the participation in important EC funded research projects, i.e. NERIES, NERA, TRANSFER, NEAMTIC and ASTARTE, demonstrates that collaboration of top class Research Institutions that care to produce important and useful results in the research front in Europe, can facilitate towards developing and operating top class Operational Centers, useful for Civil Protection purposes in regions in need. Last, it is demonstrated that HL-NTWC collaboration with important key role Research Centers in the Security and Safety issues (e

  6. Thermal simulation of drift emplacement. Geotechnical and geophysical investigations in and around backfilled galleries

    International Nuclear Information System (INIS)

    Schneefub, J.U.; Gommlich, G.E.

    1988-01-01

    The concept for the direct disposal of spent fuel in rock salt foresees the emplacement of large waste canisters on the floor of a disposal gallery. Subsequent to emplacement the drift is backfilled with salt grit. In a demonstration test six cylindrical containments are to be emplaced within distances of 3 m from each other in two parallel galleries of 14 m 2 , separated by a pillar of 10 m thickness. They will be heated up by a power output of approx. 1 kW/m to 200 degree C surface temperature by electrical heaters. The thermal and mechanical response of the salt rock and the backfilling to the artificial heating is to be investigated as follows: (1) measurement of the temperature field at the contained surface, in the backfill and in the rock salt; (2) deformation measurements of the salt rock around the heated drifts; (3) measurements of tunnel convergence in heated and unheated sections; (4) compaction measurements of the backfilling in heated and unheated areas; (5) measurement of rock stresses in areas very close to the galleries; and (6) pressure measurements in the backfilling, between backfilling and rock, and between backfilling and containers. The rock burst monitoring system of the Asse salt mine will be expanded to this special field of the mine to detect seismic events due to thermomechanical effects. Another seismoacoustic system will be installed to observe the compaction of the backfilling. This system must be calibrated for the relation between the density and velocities of seismic waves. It is planned to monitor the density by gamma-gamma log measurements. The changes in overall density during the entire experiment will be observed by gravimeter measurements of high precision

  7. Emplacement of rock avalanche material across saturated sediments, Southern Alp, New Zealand

    Science.gov (United States)

    Dufresne, A.; Davies, T. R.; McSaveney, M. J.

    2012-04-01

    The spreading of material from slope failure events is not only influenced by the volume and nature of the source material and the local topography, but also by the materials encountered in the runout path. In this study, evidence of complex interactions between rock avalanche and sedimentary runout path material were investigated at the 45 x 106 m3 long-runout (L: 4.8 km) Round Top rock avalanche deposit, New Zealand. It was sourced within myolinitic schists of the active strike-slip Alpine Fault. The narrow and in-failure-direction elongate source scarp is deep-seated, indicating slope failure was triggered by strong seismic activity. The most striking morphological deposit features are longitudinal ridges aligned radially to source. Trenching and geophysical surveys show bulldozed and sheared substrate material at ridge termini and laterally displaced sedimentary strata. The substrate failed at a minimum depth of 3 m indicating a ploughing motion of the ridges into the saturated material below. Internal avalanche compression features suggest deceleration behind the bulldozed substrate obstacle. Contorted fabric in material ahead of the ridge document substrate disruption by the overriding avalanche material deposited as the next down-motion hummock. Comparison with rock avalanches of similar volume but different emplacement environments places Round Top between longer runout avalanches emplaced over e.g. playa lake sediments and those with shorter travel distances, whose runout was apparently retarded by topographic obstacles or that entrained high-friction debris. These empirical observations indicate the importance of runout path materials on tentative trends in rock avalanche emplacement dynamics and runout behaviour.

  8. Engineering for a disposal facility using the in-room emplacement method

    Energy Technology Data Exchange (ETDEWEB)

    Baumgartner, P; Bilinsky, D M; Ates, Y; Read, R S; Crosthwaite, J L; Dixon, D A

    1996-06-01

    This report describes three nuclear fuel waste disposal vaults using the in-room emplacement method. First, a generic disposal vault design is provided which is suitable for a depth range of 500 m to 1000 m in highly stressed, sparsely fractured rock. The design process is described for all components of the system. The generic design is then applied to two different disposal vaults, one at a depth of 750 m in a low hydraulically conductive, sparsely fractured rock mass and another at a depth of 500 m in a higher conductivity, moderately fractured rock mass. In the in-room emplacement method, the disposal containers with used-fuel bundles are emplaced within the confines of the excavated rooms of a disposal vault. The discussion of the disposal-facility design process begins with a detailed description of a copper-shell, packed-particulate disposal container and the factors that influenced its design. The disposal-room generic design is presented including the detailed specifications, the scoping and numerical thermal and thermal mechanical analyses, the backfilling and sealing materials, and the operational processes. One room design is provided that meets all the requirements for a vault depth range of 500 to 1000 m. A disposal-vault layout and the factors that influenced its design are also presented, including materials handling, general logistics, and separation of radiological and nonradiological operations. Modifications to the used-fuel packaging plant for the filling and sealing of the copper-shell, packed-particulate disposal containers and a brief description of the common surface facilities needed by the disposal vault and the packaging plant are provided. The implementation of the disposal facility is outlined, describing the project stages and activities and itemizing a specific plan for each of the project stages: siting, construction, operation; decommissioning; and closure. (author). 72 refs., 15 tabs., 63 figs.

  9. Engineering for a disposal facility using the in-room emplacement method

    International Nuclear Information System (INIS)

    Baumgartner, P.; Bilinsky, D.M.; Ates, Y.; Read, R.S.; Crosthwaite, J.L.; Dixon, D.A.

    1996-06-01

    This report describes three nuclear fuel waste disposal vaults using the in-room emplacement method. First, a generic disposal vault design is provided which is suitable for a depth range of 500 m to 1000 m in highly stressed, sparsely fractured rock. The design process is described for all components of the system. The generic design is then applied to two different disposal vaults, one at a depth of 750 m in a low hydraulically conductive, sparsely fractured rock mass and another at a depth of 500 m in a higher conductivity, moderately fractured rock mass. In the in-room emplacement method, the disposal containers with used-fuel bundles are emplaced within the confines of the excavated rooms of a disposal vault. The discussion of the disposal-facility design process begins with a detailed description of a copper-shell, packed-particulate disposal container and the factors that influenced its design. The disposal-room generic design is presented including the detailed specifications, the scoping and numerical thermal and thermal mechanical analyses, the backfilling and sealing materials, and the operational processes. One room design is provided that meets all the requirements for a vault depth range of 500 to 1000 m. A disposal-vault layout and the factors that influenced its design are also presented, including materials handling, general logistics, and separation of radiological and nonradiological operations. Modifications to the used-fuel packaging plant for the filling and sealing of the copper-shell, packed-particulate disposal containers and a brief description of the common surface facilities needed by the disposal vault and the packaging plant are provided. The implementation of the disposal facility is outlined, describing the project stages and activities and itemizing a specific plan for each of the project stages: siting, construction, operation; decommissioning; and closure. (author)

  10. Characteristics and Significance of Magma Emplacement Horizons, Black Sturgeon Sill, Nipigon, Ontario

    Science.gov (United States)

    Zieg, M. J.; Hone, S. V.

    2017-12-01

    Spatial scales strongly control the timescales of processes in igneous intrusions, particularly through the thermal evolution of the magma, which in turn governs the evolution of crystallinity, viscosity, and other important physical and chemical properties of the system. In this study, we have collected a highly detailed data set comprising geochemical (bulk rock composition), textural (size and alignment of plagioclase crystals), and mineralogical (modal abundance) profiles through the central portion of the 250 m thick Black Sturgeon diabase sill. In this data, we have identified characteristic signals in texture (soft and somewhat diffuse chills), composition (reversals in differentiation trends), and mineralogy (olivine accumulations), all coinciding and recurring at roughly 10 meter intervals. Based on these signatures, we are able to map out multiple zones representing discrete pulses of magma that were emplaced sequentially as the intrusion was inflated. Simple thermal calculations suggest that each 10 meters of new crystallization would require repose times on the order of 10-100 years. To build up 250 meters of magma at this rate would only require approximately 250-2500 years, significantly less than the thermal lifetime of the entire sill. The soft chills we observe in the Black Sturgeon sill are therefore consistent with a system that remained warm throughout the emplacement process. Successive pulses were injected into partially crystalline mush, rather than pure liquid (which would result in hybridization) or solid (which would produce sharp hard chills). Episodic emplacement is by now widely recognized as a fundamental process in the formation of large felsic magma chambers; our results suggest that this also may be an important consideration in understanding the evolution of smaller mafic intrusions.

  11. Lower Crstal Reflectity bands and Magma Emplacement in Norweigian sea, NE Atlantic

    Science.gov (United States)

    Rai, A.; Breivik, A. J.; Mjelde, R.

    2013-12-01

    In this study we present the OBS data collected along seismic profiles in the norweigian sea. The traveltime modelling of the OBS data provides first-hand information about seismic structure of the subsurface. However, waveform modelling is used to further constrain the fine scale structure, velocity constrast and velocity gradients. By forward modelling and inversion of the seismic waveforms, we show that the multiple bands of reflectivity could be due to multiple episodes of magma emplacements that might have frozen in the form of sills. These mafic intrusions probably intruded into the ductile lower crust during the main rifting phase of Europe and Greenland.

  12. A review of the ascent and emplacement of granitoid bodies into the crust

    Directory of Open Access Journals (Sweden)

    Katarína Bónová

    2005-03-01

    Full Text Available This paper relates to basic information (i.e. mechanical aspects of ascent, indicators faciliting the discriminability of various ascent styles about the models of ascent and emplacement of granitoid bodies, since the purely mechanical aspect of intrusion of magmas is a fascinating subject and it has generated a considerable controversy over many years. Individual models are demonstrated by world-known occurrences and examples from Western Carpathian’s region. The conditions of magma migration are demonstrated as well.

  13. A feasibility study of the disposal of radioactive waste in deep ocean sediments by drilled emplacement

    International Nuclear Information System (INIS)

    Bury, M.R.C.

    1983-08-01

    This report describes the second phase of a study of the feasibility of disposal and isolation of high level radioactive waste in holes drilled deep into the sediments of the ocean. In this phase, work has concentrated on establishing the state of the art of the various operations and developing the design, in particular the drilling operation, the loading of flasks containing waste canisters from supply vessels onto the platform, the handling of radioactive waste on board, and its emplacement into predrilled holes. In addition, an outline design of the offshore platform has been prepared. (author)

  14. The Summer 1997 Eruption at Pillan Patera on Io: Implications for Ultrabasic Lava Flow Emplacement

    Science.gov (United States)

    Williams, David A.; Davies, Ashley G.; Keszthelyi, Laszlo P.; Greeley, Ronald

    2001-01-01

    Galileo data and numerical modeling were used to investigate the summer 1977 eruption at Pillan Patera on Io. This event, now defined as "Pillanian" eruption style, included a high-temperature (greater than 1600 C), possible ultrabasic , 140-km-high plume eruption that deposited dark, orthopyroxene-rich pyroclastic material over greater than 125,000 sq km, followed by emplacement of dark flow-like material over greater than 3100 sq km to the north of the caldera. We estimate that the high-temperature, energetic episode of this eruption had a duration of 52 - 167 days between May and September 1997, with peak eruption temperatures around June 28, 1997. Galileo 20 m/pixel images of part of the Pillan flow field show a wide-spread, rough, pitted surface that is unlike any flow surface we have seen before. We suggest that this surface may have resulted from: 1. A fractured lava crust formed during rapid, low-viscosity lava surging, perhaps including turbulent flow emplacement. 2. Disruption of the lava flow by explosive interaction with a volatile-rich substrate. or 3. A combination of 1 and 2 with or without accumulation of pyroclastic material on the surface. Well-developed flow lobes are observed, suggesting that this is a relatively distant part of the flow field.Shadow measurements at flow margins indicate a thickness of-8 - 10 m. We have modeled the emplacement of putative ultrabasic flow from the summer 1997 Pillan eruption using constraints from new Galileo data. Results suggest that either laminar sheet flows or turbulent channelized flows could have traveled 50 - 150 km on a flat, unobstructed surface, which is consistent with the estimated length of the Pillan flow field (approx. 60 km). Our modeling suggests low thermal erosion rates (less than 4.1 m/d), and that the formation of deep (greater than 20 m) erosion channels was unlikely, especially distal to the source. We calculate a volumetric flow rate of approx. 2 - 7 x 10(exp 3)cu m/s, which is greater

  15. HL7 and DICOM based integration of radiology departments with healthcare enterprise information systems.

    Science.gov (United States)

    Blazona, Bojan; Koncar, Miroslav

    2007-12-01

    Integration based on open standards, in order to achieve communication and information interoperability, is one of the key aspects of modern health care information systems. However, this requirement represents one of the major challenges for the Information and Communication Technology (ICT) solutions, as systems today use diverse technologies, proprietary protocols and communication standards which are often not interoperable. One of the main producers of clinical information in healthcare settings represent Radiology Information Systems (RIS) that communicate using widely adopted DICOM (Digital Imaging and COmmunications in Medicine) standard, but in very few cases can efficiently integrate information of interest with other systems. In this context we identified HL7 standard as the world's leading medical ICT standard that is envisioned to provide the umbrella for medical data semantic interoperability, which amongst other things represents the cornerstone for the Croatia's National Integrated Healthcare Information System (IHCIS). The aim was to explore the ability to integrate and exchange RIS originated data with Hospital Information Systems based on HL7's CDA (Clinical Document Architecture) standard. We explored the ability of HL7 CDA specifications and methodology to address the need of RIS integration HL7 based healthcare information systems. We introduced the use of WADO service interconnection to IHCIS and finally CDA rendering in widely used Internet explorers. The outcome of our pilot work proves our original assumption of HL7 standard being able to adopt radiology data into the integrated healthcare systems. Uniform DICOM to CDA translation scripts and business processes within IHCIS is desired and cost effective regarding to use of supporting IHCIS services aligned to SOA.

  16. Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes

    International Nuclear Information System (INIS)

    Pai, J.K.; Siegel, M.I.; Egan, R.W.; Billah, M.M.

    1988-01-01

    There exists circumstantial evidence for activation of phospholipase D (PLD) in intact cells. However, because of the complexity of phospholipid remodeling processes, it is essential to distinguish PLD clearly from other phospholipases and phospholipid remodeling enzymes. Therefore, to establish unequivocally PLD activity in dimethyl sulfoxide-differentiated HL-60 granulocytes, to demonstrate the relative contribution of PLD to phospholipid turnover, and to validate the hypothesis that the formation of phosphatidylethanol is an expression of PLD-catalyzed transphosphatidylation, we have developed methodologies to label HL-60 granulocytes in 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (alkyl-PC) with 32P without labeling cellular ATP. These methodologies involve (a) synthesis of alkyl-lysoPC containing 32P by a combination of enzymatic and chemical procedures and (b) incubation of HL-60 granulocytes with this alkyl-[32P] lysoPC which enters the cell and becomes acylated into membrane-associated alkyl-[32P]PC. Upon stimulation of these 32P-labeled cells with the chemotactic peptide, N-formyl-Met-Leu-Phe (fMLP), alkyl-[32P]phosphatidic acid (alkyl-[32P]PA) is formed rapidly. Because, under these conditions, cellular ATP has not been labeled with 32P, alkyl-[32P]PA must be formed via PLD-catalyzed hydrolysis of alkyl-[32P]PC at the terminal phosphodiester bond. This result conclusively demonstrates fMLP-induced activation of PLD in HL-60 granulocytes. These 32P-labeled HL-60 granulocytes have also been stimulated in the presence of ethanol to produce alkyl-[32P]phosphatidylethanol (alkyl-[32P]PEt). Formation of alkyl-[32P]PEt parallels that of alkyl-[32P]PA with respect to time course, fMLP concentration, inhibition by a specific fMLP antagonist (t-butoxycarbonyl-Met-Leu-Phe), and Ca2+ concentration

  17. Dynamical Stability of Imaged Planetary Systems in Formation: Application to HL Tau

    Science.gov (United States)

    Tamayo, D.; Triaud, A. H. M. J.; Menou, K.; Rein, H.

    2015-06-01

    A recent Atacama Large Millimeter/Submillimeter Array image revealed several concentric gaps in the protoplanetary disk surrounding the young star HL Tau. We consider the hypothesis that these gaps are carved by planets, and present a general framework for understanding the dynamical stability of such systems over typical disk lifetimes, providing estimates for the maximum planetary masses. We collect these easily evaluated constraints into a workflow that can help guide the design and interpretation of new observational campaigns and numerical simulations of gap opening in such systems. We argue that the locations of resonances should be significantly shifted in massive disks like HL Tau, and that theoretical uncertainties in the exact offset, together with observational errors, imply a large uncertainty in the dynamical state and stability in such disks. This presents an important barrier to using systems like HL Tau as a proxy for the initial conditions following planet formation. An important observational avenue to breaking this degeneracy is to search for eccentric gaps, which could implicate resonantly interacting planets. Unfortunately, massive disks like HL Tau should induce swift pericenter precession that would smear out any such eccentric features of planetary origin. This motivates pushing toward more typical, less massive disks. For a nominal non-resonant model of the HL Tau system with five planets, we find a maximum mass for the outer three bodies of approximately 2 Neptune masses. In a resonant configuration, these planets can reach at least the mass of Saturn. The inner two planets’ masses are unconstrained by dynamical stability arguments.

  18. 99MTC-HL91 spect image versus 18F-FDG PET for detection of head and neck carcinoma

    International Nuclear Information System (INIS)

    Chu, L.S.; Liu, R.S.; Chou, K.L.; Yang, B.H.; Liao, S.Q.; Yeh, S.H.

    2004-01-01

    Objective: Tumor hypoxia is a major complication of oncologic cell switch for chemotherapy(C/T) and / or radiotherapy(R/T). Such lesions detected by selective modem conventional examination remains difficult. 99mTc-HL91 is a potential agent for imaging hypoxic tissue in vivo. This study aimed to assess efficacy of 99mTc- HL91 in imaging of head and neck cancer and compared the result with 18F-fluorodeoxyglucose(FDG)PET. Methods: Sixteen pts with head and neck cancers (7 hypopharyngeal cancers, 4 laryngeal cancers, 5 tongue base cancers) were enrolled in this study. Primary tumors and suspicious local,regional metastases were diagnosed by clinical examination, CT/MRI , and biopsy. After intravenous injection of 740 MBq of 99mTc-HL91, whole body planar scan and regional SPECT at 2hr postinjection were performed. Tumor lesion -to- normal background(T/N) ratios with 3x3 pixels of background ROI were also measured. The reference range of T/N ratio greater 3.0 defined +, close to 2.4 defined +/- and less than 1.5 defined as -. The FDG images with dedicated PET system was performed at 4hr after completion of 99mTc-HL91 study. The visualized tumors uptake with ratio of standardized uptake value (SUV) greater than 2.5 defined as +.. less than 2.5 defined -. Results: In 7 hypopharyngeal cancers, there are 2FDG+/HL91+, 3FDG+/HL91-, 2FDG+/HL91+/-, In 4 laryngeal cancers, there are 3FDG+/HL91-, 1FDG+/HL91 +/-. In 5 tongue base cancers, there are 5FDG+/HL91-.(Table 1). The T/N ratios of all head and neck cancers in primary tumor and regional lymph nodes were ranged from l.3/1.5 and 1.1/1.2 respectively. The frequency of FDG + in hypopharyngeal cancers is 1.0,in laryngeal cancers is 1.0 and in tongue base cancers is 1.0. The frequency of HL91+/+/- in hypopharyngeal cancers is 0..58,in laryngeal cancers is 0.25.and in tongue base cancers is 0. The overall detection rate of head and neck cancer by FDG+ in this study is 100% and overall detection rate of local-regional hypoxia, by

  19. Architecture and emplacement of flood basalt flow fields: case studies from the Columbia River Basalt Group, NW USA

    Science.gov (United States)

    Vye-Brown, C.; Self, S.; Barry, T. L.

    2013-03-01

    The physical features and morphologies of collections of lava bodies emplaced during single eruptions (known as flow fields) can be used to understand flood basalt emplacement mechanisms. Characteristics and internal features of lava lobes and whole flow field morphologies result from the forward propagation, radial spread, and cooling of individual lobes and are used as a tool to understand the architecture of extensive flood basalt lavas. The features of three flood basalt flow fields from the Columbia River Basalt Group are presented, including the Palouse Falls flow field, a small (8,890 km2, ˜190 km3) unit by common flood basalt proportions, and visualized in three dimensions. The architecture of the Palouse Falls flow field is compared to the complex Ginkgo and more extensive Sand Hollow flow fields to investigate the degree to which simple emplacement models represent the style, as well as the spatial and temporal developments, of flow fields. Evidence from each flow field supports emplacement by inflation as the predominant mechanism producing thick lobes. Inflation enables existing lobes to transmit lava to form new lobes, thus extending the advance and spread of lava flow fields. Minimum emplacement timescales calculated for each flow field are 19.3 years for Palouse Falls, 8.3 years for Ginkgo, and 16.9 years for Sand Hollow. Simple flow fields can be traced from vent to distal areas and an emplacement sequence visualized, but those with multiple-layered lobes present a degree of complexity that make lava pathways and emplacement sequences more difficult to identify.

  20. Autoradiographic imaging of cerebral ischemia using hypoxic marker: Tc-99m-HL91 in animal models

    International Nuclear Information System (INIS)

    Jiang, N.Y.; Zhu, C.S.; Hu, X.K.

    2002-01-01

    Objective: To explore the possibility of Tc-99m-HL91 imaging in detecting the ischemic penumbra during acute stoke. Methods: 16 Sprague-Dawley (SD) rats were divided into operation group (n=12) and pseudo-operation group (n=4) randomly. In operation group, 12 middle cerebral artery occlusion animal (MCAO) models were established by electrocautery. 4 rats in pseudo-operation group were treated as a control without occlusion. All animals were injected Tc-99m-HL91 intravenously 2 hours after occlusion. Animals were killed at different time after injection and brains were removed rapidly from the skull to do the autoradiographic study. Result: The ischemic territory accumulated more Tc-99m-HL91 than the opposite site in the autoradiogram at 1 hour after injection. The ischemic cerebral tissue can be visualized clearly. At 2, 4 hours after injection, the difference of accumulation of Tc-99m-HL91 in target and non-target site became more obvious. By using computer-enhanced imaging analysis, the optical density (OD) ratio differences between each subgroup of operation group and pseudo-operation group were all significant. Conclusion : Tc-99m-HL91 can be avidly taken up by ischemic penumbra. Tc-99m-HL91 is a potential agent for imaging hypoxic tissue, and Tc-99m-HL91 SPECT may be a promising imaging method in detecting the ischemic penumbra

  1. Autoradiographic imaging of cerebral ischaemia using hypoxic marker: 99mTc-HL91 in animal models

    International Nuclear Information System (INIS)

    Ningyi, J.; Cansheng, Z.; Xiaoke, H.

    2002-01-01

    Objective: To explore the possibility of 99mTc-HL91 imaging in detecting the ischemic penumbra during acute stoke. Methods 16 Sprague-Dawley (SD) rats were divided into operation group (n=12) and pseudo-operation group (n=4) randomly. In operation group, 12 middle cerebral artery occlusion animal (MCAO) models were established by electrocautery. 4 rats in pseudo-operation group were treated as a control without occlusion. All animals were injected 99mTc-HL91 intravenously 2 hours after occlusion. Animals were killed at different time after injection and brains were removed rapidly from the skull to do the autoradiographic study. Result The ischemic territory accumulated more 99mTc-HL91 than the opposite site in the autoradiogram at 1 hour after injection. The ischemic cerebral tissue can be visualized clearly. At 2, 4 hours after injection, the difference of accumulation of 99mTc-HL91 in target and non-target site became more obvious. By using computer-enhanced imaging analysis, the optical density (OD) ratio differences between each subgroup of operation group and pseudo-operation group were all significant. Conclusion 99mTc-HL91 can be avidly taken up by ischemic penumbra. 99mTc-HL91 is a potential agent for imaging hypoxic tissue, and 99mTc-HL91 SPECT may be a promising imaging method in detecting the ischemic penumbra

  2. Lithofacies of deep marine basalts emplaced on a Jurassic backarc apron, Baja California (Mexico)

    Energy Technology Data Exchange (ETDEWEB)

    Busby-Spera, C.J.

    1987-09-01

    Basalts of the mid-Jurassic Gran Canon Formation, Cedros Island, Mexico, were emplaced on a volcaniclastic apron in a deep marine backarc basin. Elongate pillows and lava tubes, as well as paleocurrent data from the volcaniclastic apron, indicate a southward regional paleoslope away from the island arc source. Basalts emplaced on relatively proximal parts of the apron are nearly entirely pillowed and have thick flow units with mega-pillows. Basalts on distal parts of the apron (about 15 to 20 km down paleo-current) are dominated by pillow fragment breccias (flow foot rubble), and individual lava flows are generally thin, with small pillows, suggesting that the distal ends of lava flows, erupted upslope, are represented. These distal flow fronts, however, are interstratified with features that typically form close to a vent, including thick massive to mega-pillowed lavas and lava tubes up to 8 m in diameter. It is inferred that a fissure (or system of fissures) extended from the arc into the backarc basin, erupting basalt lavas onto both proximal and distal parts of the volcaniclastic apron. Such intraplate volcanism may be common on the hot frontal arc side of backarc basins. 26 references.

  3. Hazard and consequence analysis for waste emplacement at the Waste Isolation Pilot Plant

    International Nuclear Information System (INIS)

    Gerstner, D.M.; Clayton, S.G.; Farrell, R.F.; McCormick, J.A.; Ortiz, C.; Standiford, D.L.

    1996-01-01

    The Carlsbad Area Office established and analyzed the safety bases for the design and operations as documented in the WIPP Safety Analysis Report (SAR). Additional independent efforts are currently underway to assess the hazards associated with the long-term (10,000 year) isolation period as required by 40 CFR 191. The structure of the WIPP SAR is unique due to the hazards involved, and the agreement between the State of New Mexico and the DOE regarding SAR content and format. However, the hazards and accident analysis philosophy as contained in DOE-STD-3009-94 was followed as closely as possible, while adhering to state agreements. Hazards associated with WIPP waste receipt, emplacement, and disposal operations were systematically identified using a modified Hazard and Operability Study (HAZOP) technique. The WIPP HAZOP assessed the potential internal, external, and natural phenomena events that can cause the identified hazards to develop into accidents. The hazard assessment identified deviations from the intended design and operation of the waste handling system, analyzed potential accident consequences to the public and workers, estimated likelihood of occurrence, and evaluated associated preventative and mitigative features. It was concluded from the assessment that the proposed WIPP waste emplacement operations and design are sufficient to ensure safety of the public, workers, and environment, over the 35 year disposal phase

  4. Effects of the deviation characteristics of nuclear waste emplacement boreholes on borehole liner stresses

    International Nuclear Information System (INIS)

    Glowka, D.A.

    1990-09-01

    This report investigates the effects of borehole deviation on the useability of lined boreholes for the disposal of high-level nuclear waste at the proposed Yucca Mountain Repository in Nevada. Items that lead to constraints on borehole deviation include excessive stresses that could cause liner failure and possible binding of a waste container inside the liner during waste emplacement and retrieval operations. Liner stress models are developed for two general borehole configurations, one for boreholes drilled with a steerable bit and one for boreholes drilled with a non-steerable bit. Procedures are developed for calculating liner stresses that arise both during insertion of the liner into a borehole and during the thermal expansion process that follows waste emplacement. The effects of borehole curvature on the ability of the waste container to pass freely inside the liner without binding are also examined. Based on the results, specifications on borehole deviation allowances are developed for specific vertical and horizontal borehole configurations of current interest. 11 refs., 22 figs., 4 tabs

  5. Analysis of Surface Leaching Processes in Vitrified High-Level Nuclear Wastes Using In-Situ Raman Imaging and Atomistic Modeling - Final Report

    International Nuclear Information System (INIS)

    Simmons, Joseph H.

    2001-01-01

    The in situ analysis of surface conditions of vitrified nuclear wastes can provide an important check of the burial status of radioactive objects without risk of radiation exposure. Raman spectroscopy was initially chosen as the most promising method for testing the surface conditions of glasses undergoing chemical corrosion, and was used extensively during the first year. However, it was determined that infrared reflection spectroscopy was better suited to this particular need and was used for the remaining two years to investigate the surface corrosion behavior of model silicate glasses for extension to nuclear waste glasses. The developed methodology is consistent with the known theory of optical propagation of dielectric media and uses the Kramers-Kronig formalism. The results show that it is possible to study the corrosion of glass by analyzing the glass surface using reflection fast Fourier infrared measurements and the newly developed ''dispersion analysis method.'' The data show how this analysis can be used to monitor the corrosion behavior of vitrified waste glasses over extended periods of storage

  6. Geochronological Constraints on the Exhumation and Emplacement of Subcontinental Lithospheric Mantle Peridotites in the Westernmost Mediterranean

    Science.gov (United States)

    Garrido, Carlos J.; Hidas, Károly; Marchesi, Claudio; Varas-Reus, María Isabel; Booth-Rea, Guillermo

    2017-04-01

    Exhumation of subcontinental mantle peridotite in the Western Mediterranean has been attributed to different tectonic processes including pure extension, transpression, or alternating contractive and extensional processes related with continental subduction followed by extension, before final their contractive intracrustal emplacement. Any model trying to explain the exhumation and emplacement of subcontinental lithospheric mantle peridotites in the westernmost Mediterranean should take into account the available geochronological constraints, as well as the petrological and geochemical processes that lead to internal tectono-magmatic zoning so characteristic of the Betic and Rif orogenic peridotites. Different studies have suggested a Hercynian, Cenozoic-Mesozoic or an Alpine age for the late tectono-magmatic evolution and intra-crustal emplacement of Betic-Rif peridotites. The pervasive presence of Mesozoic U-Pb zircon ages in Ronda UHP and HP garnet pyroxenites does not support a Hercynian age for the intracrustal emplacement of the peridotite. A hyper-extended margin setting for is in good agreement with the Jurassic extensional event that pervasively affected ALKAPECA terrains (i.e. the Alboran, Kabylides, Peloritani, and Calabria domains) in the western Mediterranean due to the opening of the Piemonte-Ligurian Ocean. However, a Jurassic age and a passive margin tectonic setting do not account, among other observations, for the late Miocene thermochronological ages recorded in zircons rims (U-Pb) and garnets (Lu-Hf) in garnet pyroxenites from the Betic-Rif peridotites, the pervasive Miocene resetting of U-Pb zircon and monazite ages in the overlying Jubrique crustal section, the supra-subduction radiogenic signature of late pyroxenite intrusive dikes in the Ronda peridotite, and the arc tholeiitic affinity of late mantle-derived, gabbroic dykes intruding in the Ronda and Ojen plagioclase lherzolites. These data are more consistent with a supra

  7. Study on a transportation and emplacement system of pre-assembled EBS module for HLW geological disposal

    International Nuclear Information System (INIS)

    Awano, Toshihiko; Kanno, Takeshi; Katsumata, Syunsuke; Kosuge, Kazuhiro

    2009-01-01

    HLW disposal is one of the largest issue to utilize Nuclear power safely. In the past study, the concept, which buffer materials and Overpacked waste were transported into underground respectively, have shown. The concept of pre-assembled engineered barrier has advantage to simplify the logistics and emplacement procedure, however there are difficulties to support heavy weight of pre-assembled package by equipment under the condition of little clearance between tunnel and package. In this study, Combination of air bearing and two degree-of-freedom wheels were suggested for transportation, and air jack was suggested for unloading and emplacement system. Also, whole system for transportation and emplacement procedure was designed, and Scale model test was examined to evaluate the feasibility of these concept and functions. (author)

  8. Synthesis and Structures of Two Lanthanide Complexes Containing a Mixed Ligand System: [Ln(Phen)2(L)3(HL)]·H2O [Ln = La, Ce; Phen = Phenanthroline; HL = Salicylic Acid

    International Nuclear Information System (INIS)

    Iravani, Effat; Nami, Navabeh; Nabizadeh, Fatemeh; Bayani, Elham; Neumueller, Bernhard

    2013-01-01

    The reaction of LnCl 3 ·7H 2 O [Ln = La (1), Ce (2)] with salicylic acid (HL) and 1,10-phenanthroline (Phen) at 20 .deg. C in H 2 O/ethanol gave after work-up and recrystallization two novel lanthanide complexes with general formula [Ln(Phen) 2 (L) 3 (HL)]·H 2 O. Compounds 1 and 2 were characterized by IR and UV-Vis spectroscopy, TGA, CHN as well as by X-ray analysis. According to these results, compounds 1 and 2 are isostructural and contain Ln 3+ ions with coordination number nine. Complexes 1 and 2 consist of two Phen, one neutral HL and three L anions (two L anions act as monodentate ligands and the third one is chelating to Ln 3+ ). Thermal decomposition led to primary loss of the Phen molecules. Then HL molecules and finally L moieties left the material to give Ln 2 O 3

  9. Determination of the Structure of Vitrified Hydroceramic/CBC Waste Form Glasses Manufactured from DOE Reprocessing Waste

    International Nuclear Information System (INIS)

    Scheetz, B.E.; White, W. B.; Chesleigh, M.; Portanova, A.; Olanrewaju, J.

    2005-01-01

    The selection of a glass-making option for the solidification of nuclear waste has dominated DOE waste form programs since the early 1980's. Both West Valley and Savannah River are routinely manufacturing glass logs from the high level waste inventory in tank sludges. However, for some wastes, direct conversion to glass is clearly not the optimum strategy for immobilization. INEEL, for example, has approximately 4400 m 3 of calcined high level waste with an activity that produces approximately 45 watts/m 3 , a rather low concentration of radioactive constituents. For these wastes, there is value in seeking alternatives to glass. An alternative approach has been developed and the efficacy of the process demonstrated that offers a significant savings in both human health and safety exposures and also a lower cost relative to the vitrification option. The alternative approach utilizes the intrinsic chemical reactivity of the highly alkaline waste with the addition of aluminosilicate admixtures in the appropriate proportions to form zeolites. The process is one in which a chemically bonded ceramic is produced. The driving force for reaction is derived from the chemical system itself at very modest temperatures and yet forms predominantly crystalline phases. Because the chemically bonded ceramic requires an aqueous medium to serve as a vehicle for the chemical reaction, the proposed zeolite-containing waste form can more adequately be described as a hydroceramic. The hydrated crystalline materials are then subject to hot isostatic pressing (HIP) which partially melts the material to form a glass ceramic. The scientific advantages of the hydroceramic/CBC approach are: (1) Low temperature processing; (2) High waste loading and thus only modest volumetric bulking from the addition of admixtures; (3) Ability to immobilize sodium; (4) Ability to handle low levels of nitrate (2-3% NO 3 - ); (5) The flexibility of a vitrifiable waste; and (6) A process that is based on an

  10. Optical data transmission ASICs for the high-luminosity LHC (HL-LHC) experiments

    International Nuclear Information System (INIS)

    Li, X; Huang, G; Sun, X; Liu, G; Deng, B; Gong, D; Guo, D; Liu, C; Liu, T; Xiang, A C; Ye, J; Zhao, X; Chen, J; You, Y; He, M; Hou, S; Teng, P-K; Jin, G; Liang, H; Liang, F

    2014-01-01

    We present the design and test results of two optical data transmission ASICs for the High-Luminosity LHC (HL-LHC) experiments. These ASICs include a two-channel serializer (LOCs2) and a single-channel Vertical Cavity Surface Emitting Laser (VCSEL) driver (LOCld1V2). Both ASICs are fabricated in a commercial 0.25-μm Silicon-on-Sapphire (SoS) CMOS technology and operate at a data rate up to 8 Gbps per channel. The power consumption of LOCs2 and LOCld1V2 are 1.25 W and 0.27 W at 8-Gbps data rate, respectively. LOCld1V2 has been verified meeting the radiation-tolerance requirements for HL-LHC experiments

  11. Design and construction of high-frequency magnetic probe system on the HL-2A tokamak

    Science.gov (United States)

    Liang, S. Y.; Ji, X. Q.; Sun, T. F.; Xu, Yuan; Lu, J.; Yuan, B. S.; Ren, L. L.; Yang, Q. W.

    2017-12-01

    A high-frequency magnetic probe system is designed, calibrated and constructed on the HL-2A tokamak. To investigate the factors which affect the probe frequency response, the inductance and capacitance in the probe system are analyzed using an equivalent circuit. Suitable sizes and turn number of the coil, and the length of transmission cable are optimized based on the theory and detailed test in the calibration. To deal with the frequency response limitation and bake-out, the ceramic grooved technique is used and the probe is wound with a bare copper wire. A cascade filter is manufactured with a suitable bandwidth as well as a good phase consistency between channels. The system has been used in the experiment to measure high frequency (≤300 kHz) magnetohydrodynamic fluctuations, which can meet the requirement of physical analysis on HL-2A.

  12. Cleaning of the first mirrors and diagnostic windows by YAG laser on HL-2A

    International Nuclear Information System (INIS)

    Zhou, Y; Zheng, L; Li, Y G; Li, L C; Jiao, Y M; Gao, H; Zhao, G

    2009-01-01

    A laser cleaning system for HL-2A tokamak first mirrors and diagnostic windows has been developed recently. A detailed description of the laser cleaning procedure is presented. The optical transmission performance measured before and after the laser cleaning of the impurity film deposited on the optical elements is investigated. HL-2A deposited layers on metal mirrors and glass windows with thicknesses of about 1 and 4 μm, respectively, are clearly removed by irradiation with a single pulse of a Q-switched Nd:YAG laser with energy density of 0.4 and 2.8 J cm -2 , respectively. The feasibility of cleaning ECE windows is demonstrated. A cleaning time of about 5 min is suitable for application in fusion devices. The comparison of results obtained at different laser wavelengths shows that there is a greater probability of damage to the metallic mirror surface with a short laser wavelength than with longer wavelength.

  13. Associative Memory pattern matching for L1 track trigger for the HL-LHC CMS

    CERN Document Server

    Fedi, Giacomo

    2016-01-01

    The High Luminosity LHC (HL-LHC) will deliver a luminosity of up to $5 × 10^{34}cm^{−2}s^{−1}$, with an average of about 140 overlapping proton-proton collisions per bunch crossing. These extreme pileup conditions place stringent requirements on the trigger system to be able to cope with the resulting event rates. A key component of the CMS upgrade for HL-LHC is a track trigger system, able to identify tracks with transverse momenta above 2 GeV/c already at the first-level trigger. We present here the status of the implementation of a prototype system, based on the combination of Associative Memory custom ASIC and modern Field Programmable Gate Array (FPGA) devices, with the purpose to demonstrate the concept based on state-of-the-art technologies, and to direct the efforts of the necessary R&D toward a final system.

  14. Snake perturbations during pellet injection and LHCD in the HL-1M tokamak

    International Nuclear Information System (INIS)

    Liu Yi; Qiu Xiaoming; Dong Yunbo; Zhong Yunzhe; Fu Bingzhong; Jiafu Dong Yong Liu

    2005-01-01

    Excitation of snake perturbations has been observed in the core region of pellet-fuelled HL-1M plasmas when the pellets cross surface with q value 1. Through measurements of plasma q profile by means of multi-exposures with CCD camera during pellet ablation, and investigation on pellet ablation process, possible mechanisms for the formation of snake oscillation are discussed. In addition, a large, long-lived snake-like oscillation is frequently observed in lower hybrid current driven discharge in which the sawtooth has been stabilized at early times. There is evidence that such a perturbation is due to impurity accumulation during sawtooth-stabilization, and the good performance with peaking profiles after LHCD is limited by magnetohydrodynamic (MHD) instabilities including sawtooth and snake activities in HL-1M plasma. (author)

  15. The conceptual design for the modification of HL-2A tokamak

    International Nuclear Information System (INIS)

    Dequan Liu

    2006-01-01

    The medium-sized tokamak HL-2A, based on the former ASDEX's main components has approached its rating operational parameters with I p = 450 kA and B T =2.8 T so far. The HL-2A was originally designed to operate under an axisymmetrical double-null configuration by two triplets of shaping coils located in the vacuum vessel. Because the shaping coils were set very close to the plasma column, the nulls are normally fixed and the plasma has a nearly circular cross-section. It is difficult to increase the parameters further and obtain a preferable plasma shape with certain values of triangularity and elongation. Due to the defects on upper shaping coils' electrical insulation, the HL-2A is presently just operated with lower single null divertor configuration. Additionally, the experiment has to occasionally terminate due to incidental damages of the weak parts. With the experimental progress on HL-2A, the plasma stored energy and auxiliary heating power is being increased, a more efficient, compact and tight divertor is needed. Based on present status of HL-2A tokamak and for satisfying the requirements of the experiment, the modification of HL-2A tokamak device will be carried out. The modification design of HL-2A intents to obtain optimized plasma parameters, e.g., aspect ratio, I p , b, plasma volume, certain plasma shaping with preferable elongation and triangularity, a stable vacuum vessel easy to be maintained and an advanced divertor. The primary consideration of the modification is to take all of the shaping coils out of the vessel to enlarge the plasma volume. The elongated and triangular cross section with double null of plasma is to be obtained by composite distribution of eight sets of poloidal coils. Because all poloidal coils will be located between the TF coil and the vessel, the vacuum vessel will be remade with a smaller size to make rooms for the poloidal coil system. With an optimized operation mode, the volt-second of the plasma may be increased a

  16. HL-60 differentiating activity and flavonoid content of the readily extractable fraction prepared from citrus juices.

    Science.gov (United States)

    Kawaii, S; Tomono, Y; Katase, E; Ogawa, K; Yano, M

    1999-01-01

    Citrus plants are rich sources of various bioactive flavonoids. To eliminate masking effects caused by hesperidin, naringin, and neoeriocitrin, the abundant flavonoid glycosides which make up 90% of the conventionally prepared sample, the readily extractable fraction from Citrus juice was prepared by adsorbing on HP-20 resin and eluting with EtOH and acetone from the resin and was subjected to HL-60 differentiation assay and quantitative analysis of major flavonoids. Screening of 34 Citrus juices indicated that King (C. nobilis) had a potent activity for inducing differentiation of HL-60, and the active principles were isolated and identified as four polymethoxylated flavonoids, namely, nobiletin, 3,3',4',5,6,7, 8-heptamethoxyflavone, natsudaidain, and tangeretin. HPLC analysis of the readily extractable fraction also indicated that King contained high amounts of these polymethoxylated flavonoids among the Citrus juices examined. Principal component and cluster analyses of the readily extractable flavonoids indicated peculiarities of King and Bergamot.

  17. Differentiation-inducing effects of small fruit juices on HL-60 leukemic cells.

    Science.gov (United States)

    Yoshizawa, Y; Kawaii, S; Urashima, M; Fukase, T; Sato, T; Murofushi, N; Nishimura, H

    2000-08-01

    Epidemiological studies indicate that high intakes of fruits and vegetables are associated with a reduced risk of cancer, and several plant-derived drugs have been developed in medical oncology. Since only a small part of the flora has been tested for any kind of bioactivity, we chose small fruits as sources of differentiation-inducing activity against HL-60 leukemic cells. We have prepared juices from various small fruits that grow mainly in the northern part of Japan. Screening of 43 samples indicated that juices of Actinidia polygama Maxim., Rosa rugosa Thunb., Vaccinium smallii A. Gray, and Sorbus sambucifolia Roem. strongly induced differentiation of HL-60 cells to monocyte/macrophage characteristics in a concentration-dependent manner as indicated by histochemical and biochemical examinations.

  18. Preliminary Study of Ideal Operational MHD Beta Limit in HL-2A Tokamak Plasmas

    International Nuclear Information System (INIS)

    Shen Yong; Dong Jiaqi; He Hongda; Turnbull, A. D.

    2009-01-01

    Magnetohydrodynamic (MHD) n = 1 kink mode with n the toroidal mode number is studied and the operational beta limit, constrained by the mode, is calculated for the equilibrium of HL-2A by using the GATO code. Approximately the same beta limit is obtained for configurations with a value of the axial safety factor q 0 both larger and less than 1. Without the stabilization of the conducting wall, the beta limit is found to be 0.821% corresponding to a normalized beta value of β c N = 2.56 for a typical HL-2A discharge with a plasma current I p = 0.245 MA, and the scaling of β c N ∼constant is confirmed. (magnetically confined plasma)

  19. Induction of apoptosis by Citrus paradisi essential oil in human leukemic (HL-60) cells.

    Science.gov (United States)

    Hata, Tomona; Sakaguchi, Ikuyo; Mori, Masahiro; Ikeda, Norikazu; Kato, Yoshiko; Minamino, Miki; Watabe, Kazuhito

    2003-01-01

    Limonene is a primary component of citrus essential oils (EOs) and has been reported to induce apoptosis on tumor cells. Little is known about induction of apoptosis by citrus EOs. In this study, we examined induction of apoptosis by Citrus aurantium var. dulcis (sweet orange) EO, Citrus paradisi (grapefruit) EO and Citrus limon (lemon) EO. These EOs induced apoptosis in HL-60 cells and the apoptosis activities were related to the limonene content of the EOs. Moreover, sweet orange EO and grapefruit EO may contain components besides limonene that have apoptotic activity. To identify the components with apoptotic activity, grapefruit EO was fractionated using silica gel columns, and the components were analyzed by GC-MS. The n-hexane fraction contained limonene, and the dichloromethane fraction (DF) contained aldehyde compounds and nootkatone. Decanal, octanal and citral in the DF showed strong apoptotic activity, suggesting that the aldehyde compounds induced apoptosis strongly in HL-60 cells.

  20. Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells.

    Science.gov (United States)

    Mata-Greenwood, E; Ito, A; Westenburg, H; Cui, B; Mehta, R G; Kinghorn, A D; Pezzuto, J M

    2001-01-01

    Non-physiological inducers of terminal differentiation have been used as novel therapies for the prevention and therapy of cancer. We have used cultured HL-60 promyelocytic cells to monitor differentiation, proliferation and cell death events as induced by a large set of extracts derived from plants. Screening of more than 1400 extracts led to the discovery of 34 with potent activity (ED50 Petiveria alliacea, and desmethylrocaglamide from Aglaia ponapensis. Zapotin demonstrated the most favorable biological profile in that induction of differentiation correlated with proliferation arrest, and a lack of cytotoxicity. We conclude that the HL-60 cell model is a useful system for the discovery of novel pharmacophores with potential to suppress the process of carcinogenesis, and that flavonoids may be especially useful in this capacity.

  1. Sensor R&D for the CMS Tracker Upgrade for the HL-LHC

    CERN Document Server

    Behnamian, Hadi

    2014-01-01

    At an instantaneous luminosity of $5\\times 10^{34} cm^{-2} s^{-1}$, the high-luminosity phase of the Large Hadron Collider (HL-LHC) is expected to deliver a total of 3000 $fb^{-1}$ of collisions, hereby increasing the discovery potential of the LHC experiments significantly. However, the radiation environment of the tracking system will be severe, requiring new radiation hard sensors for the CMS tracker. The CMS tracker collaboration has almost completed a large material investigation and irradiation campaign to identify the silicon material and design that fulfills all requirements of a new tracking detector at HL-LHC. Focusing on the upgrade of the outer tracker region, pad diodes as well as fully functional strip sensors have been implemented on silicon wafers with different material properties and thicknesses. The samples were irradiated with a mixture of neutrons and protons corresponding to fluences as expected for various positions in the future tracker. The measurements performed on the structures inc...

  2. Neutral pressure measured by fast ionization gauge in HL-2A

    International Nuclear Information System (INIS)

    Wang, M.X.; Yan, L.W.; Hong, W.Y.; Cui, Z.Y.; Pan, Y.D.; Yao, L.H.; Cao, Z.; Yang, Q.W.; Liu, Y.

    2007-01-01

    A fast ionization gauge capable of working in a strong magnetic field and noisy environment is developed for the pressure measurement in the main chamber and the divertor chamber of the HL-2A tokamak. The neutral pressure in the main chamber evidently decreases after in-situ siliconization. Improvement of boundary plasma confinement is observed with SMBI or PI fueling after siliconization. The neutral pressure in the main chamber for divertor configuration is 50% lower than that for limiter one. The pressure in the divertor chamber rises when the strike point moves toward the bottom of the vertical target plates. The maximum pressure compression of is 24. The relative high pressure in the main chamber is contributed primarily by plasma limiter interaction due to the short distance from separatrix to limiter and secondly by neutral flux from the divertor chamber to the main chamber by leaks in HL-2A

  3. Future Plans of the ATLAS Collaboration for the HL-LHC

    CERN Document Server

    Hristova, Ivana; The ATLAS collaboration

    2018-01-01

    These proceedings report the current plans to upgrade the ATLAS detector at CERN for the High Luminosity LHC (HL-LHC). The HL-LHC is expected to start operations in the middle of 2026, aiming to reach an ultimate peak instantaneous luminosity of 7.5$\\times10^{34}$cm$^{-2}$s$^{-1}$, corresponding to approximately 200 inelastic proton-proton collisions per bunch crossing, and to deliver over a period of twelve years more than ten times the integrated luminosity of the large hadron collider (LHC) Runs 1-3 combined (up to $4000$ fb$^{-1}$). This is a huge challenge to all sub-systems of the detector which will need extensive upgrades to allow the experiment to pursue a rich and interesting physics programme in the future.

  4. The Influence of Topography on the Emplacement Dynamics of Martian Lava flows

    Science.gov (United States)

    Tremblay, J.; Fitch, E. P.; Fagents, S. A.

    2017-12-01

    Lava flows on the Martian surface exhibit a diverse array of complex morphologies. Previous emplacement models, based on terrestrial flows, do not fully account for these observed complex morphologies. We assert that the topography encountered by the flow can exert substantial control over the thermal, rheological, and morphological evolution of the flow, and that these effects can be better incorporated into flow models to predict Martian flow morphologies. Our development of an updated model can be used to account for these topographical effects and better constrain flow parameters. The model predicts that a slope break or flow meander induces eddy currents within the flow, resulting in the disruption of the flow surface crust. The exposure of the flow core results in accelerated cooling of the flow and a resultant increase in viscosity, leading to slowing of the flow. A constant source lava flux and a stagnated flow channel would then result in observable morphological changes, such as overflowing of channel levees. We have identified five morphological types of Martian flows, representing a range of effusion rates, eruption durations and topographic settings, which are suitable for application of our model. To characterize flow morphology, we used imaging and topographic data sets to collect data on flow dimensions. For eight large (50 to hundreds of km long) channelized flows in the Tharsis region, we used the MOLA 128 ppd DEM and/or individual MOLA shot points to derive flow cross-sectional thickness profiles, from which we calculated the cross-sectional area of the flow margins adjacent to the main channel. We found that the largest flow margin cross sectional areas (excluding the channel) occur in association with a channel bend, typically near the bend apex. Analysis of high-resolution images indicates that these widened flow margins are the result of repeated overflows of the channel levees and emplacement of short flow lobes adjacent to the main flow. In

  5. Magnetically Induced Disk Winds and Transport in the HL Tau Disk

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Yasuhiro; Flock, Mario; Turner, Neal J. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Okuzumi, Satoshi, E-mail: yasuhiro@caltech.edu [Department of Earth and Planetary Sciences, Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8551 (Japan)

    2017-08-10

    The mechanism of angular momentum transport in protoplanetary disks is fundamental to understanding the distributions of gas and dust in the disks. The unprecedented ALMA observations taken toward HL Tau at high spatial resolution and subsequent radiative transfer modeling reveal that a high degree of dust settling is currently achieved in the outer part of the HL Tau disk. Previous observations, however, suggest a high disk accretion rate onto the central star. This configuration is not necessarily intuitive in the framework of the conventional viscous disk model, since efficient accretion generally requires a high level of turbulence, which can suppress dust settling considerably. We develop a simplified, semi-analytical disk model to examine under what condition these two properties can be realized in a single model. Recent, non-ideal MHD simulations are utilized to realistically model the angular momentum transport both radially via MHD turbulence and vertically via magnetically induced disk winds. We find that the HL Tau disk configuration can be reproduced well when disk winds are properly taken into account. While the resulting disk properties are likely consistent with other observational results, such an ideal situation can be established only if the plasma β at the disk midplane is β {sub 0} ≃ 2 × 10{sup 4} under the assumption of steady accretion. Equivalently, the vertical magnetic flux at 100 au is about 0.2 mG. More detailed modeling is needed to fully identify the origin of the disk accretion and quantitatively examine plausible mechanisms behind the observed gap structures in the HL Tau disk.

  6. A new biphenyl derivative from the mangrove endophytic fungus Phomopsis longicolla HL-2232.

    Science.gov (United States)

    Li, Xiao-Bao; Chen, Guang-Ying; Liu, Rui-Jie; Zheng, Cai-Juan; Song, Xin-Ming; Han, Chang-Ri

    2017-10-01

    A new biphenyl derivative 5,5'-dimethoxybiphenyl-2,2'-diol (1), together with five known compounds (2-5), was isolated from the mangrove endophytic fungus Phomopsis longicolla HL-2232. The structures of these compounds were elucidated using comprehensive spectroscopic methods. The absolute configuration of 4 was determined by single-crystal X-ray diffraction for the first time. The inhibitory activities of all compounds against two Vibrio bacteria were evaluated.

  7. Preliminary application of maximum likelihood method in HL-2A Thomson scattering system

    International Nuclear Information System (INIS)

    Yao Ke; Huang Yuan; Feng Zhen; Liu Chunhua; Li Enping; Nie Lin

    2010-01-01

    Maximum likelihood method to process the data of HL-2A Thomson scattering system is presented. Using mathematical statistics, this method maximizes the possibility of the likeness between the theoretical data and the observed data, so that we could get more accurate result. It has been proved to be applicable in comparison with that of the ratios method, and some of the drawbacks in ratios method do not exist in this new one. (authors)

  8. The VTRx+, an optical link module for data transmission at HL-LHC

    CERN Document Server

    Troska, Jan; Detraz, Stephane; Kraxner, Andrea; Olanterä, Lauri; Scarcella, Carmelo; Sigaud, Christophe; Soos, Csaba; Vasey, Francois

    2017-01-01

    Optical data transmission will remain a key enabling technology for the upgrading detectors at HL-LHC. In particular the inner tracking detectors will require low-mass, radiation tolerant optical transmit and receive modules for tight integration in the detector front-ends. We describe the development of such a module, giving details of the design, functional and environmental performance, as well as showing the feasibility of achieving small size, low-mass, and low-power operation.

  9. A study on apoptotic signaling pathway in HL-60 cells induced by radiation

    International Nuclear Information System (INIS)

    Kim, Hye Jung; Moon, Sung Keun; Lee, Jae Hoon; Moon, Sun Rock

    2001-01-01

    The mechanical insights of death at cancer cells by ionizing radiation are not yet clearly defined. Recent evidences have demonstrated that radiation therapy may induce cell death via activation of signaling pathway for apoptosis in target cells. This study is designed whether ionizing radiation may activate the signaling cascades of apoptosis including caspase family cysteine proteases, Bcl2/Bax, cytochrome c and Fas/Fas-L in target cells. HL-60 cells were irradiated in vitro with 6 MV X-ray at dose ranges from 2 Gy to 32 Gy. The cell viability was tested by MTT assay and the extent of apoptosis was determined using agarose gel electrophoresis. The activities of caspase proteases were measured by proteolytic cleavages of substrates. Western blot analysis was used to monitor PARP, caspase-3, Cytochrome-c, BcI-2, Bax, Fas and Fas-L. Ionizing radiation decreases the viability of HL -60 cells in a time and dose dependent manner. Ionizing radiation-induced death in HL- 60 cells is an apoptotic death which is revealed as characteristic ladder-pattern fragmentation at genomic DNA over 16 Gy at 4 hours. Ionizing radiation induces the activation of caspase-2, 3, 6, 8 and 9 of HL --60 cells in a time-dependent manner. The activation of caspase- 3 protease is also evidenced by the digestion of poly (ADP-ribose) polymerase and procaspase 3 with 16Gy ionizing irradiation. Anti-apoptotic Bcl2 expression is decreased but apoptotic Bax expression is increased with mitochondrial cytochrome c release in a time- dependent manner. In addition, expression of Fas and Fas-L is also increased in a time dependent manner. These data suggest that ionizing radiation-induced apoptosis is mediated by the activation of various signaling pathways including caspase family cysteine proteases, BcI 2 /Bax, Fas and Fas-L in a time and dose dependent manner

  10. Magnetically Induced Disk Winds and Transport in the HL Tau Disk

    International Nuclear Information System (INIS)

    Hasegawa, Yasuhiro; Flock, Mario; Turner, Neal J.; Okuzumi, Satoshi

    2017-01-01

    The mechanism of angular momentum transport in protoplanetary disks is fundamental to understanding the distributions of gas and dust in the disks. The unprecedented ALMA observations taken toward HL Tau at high spatial resolution and subsequent radiative transfer modeling reveal that a high degree of dust settling is currently achieved in the outer part of the HL Tau disk. Previous observations, however, suggest a high disk accretion rate onto the central star. This configuration is not necessarily intuitive in the framework of the conventional viscous disk model, since efficient accretion generally requires a high level of turbulence, which can suppress dust settling considerably. We develop a simplified, semi-analytical disk model to examine under what condition these two properties can be realized in a single model. Recent, non-ideal MHD simulations are utilized to realistically model the angular momentum transport both radially via MHD turbulence and vertically via magnetically induced disk winds. We find that the HL Tau disk configuration can be reproduced well when disk winds are properly taken into account. While the resulting disk properties are likely consistent with other observational results, such an ideal situation can be established only if the plasma β at the disk midplane is β 0 ≃ 2 × 10 4 under the assumption of steady accretion. Equivalently, the vertical magnetic flux at 100 au is about 0.2 mG. More detailed modeling is needed to fully identify the origin of the disk accretion and quantitatively examine plausible mechanisms behind the observed gap structures in the HL Tau disk.

  11. Dynamical Stability of Imaged Planetary Systems in Formation: Application to HL Tau

    OpenAIRE

    Tamayo, Daniel; Triaud, Amaury H. M. J.; Menou, Kristen; Rein, Hanno

    2015-01-01

    A recent ALMA image revealed several concentric gaps in the protoplanetary disk surrounding the young star HL Tau. We consider the hypothesis that these gaps are carved by planets, and present a general framework for understanding the dynamical stability of such systems over typical disk lifetimes, providing estimates for the maximum planetary masses. We collect these easily evaluated constraints into a workflow that can help guide the design and interpretation of new observational campaigns ...

  12. Semantic Interoperability in Czech Healthcare Environment Supported by HL7 Version 3

    Czech Academy of Sciences Publication Activity Database

    Nagy, Miroslav; Hanzlíček, Petr; Přečková, Petra; Říha, Antonín; Dioszegi, Matěj; Seidl, Libor; Zvárová, Jana

    2010-01-01

    Roč. 49, č. 2 (2010), s. 186-195 ISSN 0026-1270 R&D Projects: GA MŠk(CZ) 1M06014; GA AV ČR 1ET200300413 Institutional research plan: CEZ:AV0Z10300504 Keywords : information storage and retrieval * electronic health record * HL7 * semantic interoperability * communication standards Subject RIV: IN - Informatics, Computer Science Impact factor: 1.472, year: 2010

  13. Clinicopathologic consensus study of gray zone lymphoma with features intermediate between DLBCL and classical HL.

    Science.gov (United States)

    Pilichowska, Monika; Pittaluga, Stefania; Ferry, Judith A; Hemminger, Jessica; Chang, Hong; Kanakry, Jennifer A; Sehn, Laurie H; Feldman, Tatyana; Abramson, Jeremy S; Kritharis, Athena; Hernandez-Ilizaliturri, Francisco J; Lossos, Izidore S; Press, Oliver W; Fenske, Timothy S; Friedberg, Jonathan W; Vose, Julie M; Blum, Kristie A; Jagadeesh, Deepa; Woda, Bruce; Gupta, Gaurav K; Gascoyne, Randy D; Jaffe, Elaine S; Evens, Andrew M

    2017-12-12

    Gray zone lymphoma (GZL) is described as sharing features with classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL). However, there remains complexity in establishing diagnosis, delineating prognosis, and determining optimum therapy. Sixty-eight cases diagnosed as GZL across 15 North American academic centers were evaluated by central pathology review to achieve consensus. Of these, only 26 (38%) were confirmed as GZL. Morphology was critical to GZL consensus diagnosis (eg, tumor cell richness); immunohistochemistry showed universal B-cell derivation, frequent CD30 expression, and rare Epstein-Barr virus (EBV) positivity (CD20 + , 83%; PAX5 + , 100%; BCL6 + , 20%; MUM1 + , 100%; CD30 + , 92%; EBV + , 4%). Forty-two cases were reclassified: nodular sclerosis (NS) cHL, n = 27 (including n = 10 NS grade 2); lymphocyte predominant HL, n = 4; DLBCL, n = 4; EBV + DLBCL, n = 3; primary mediastinal large BCL n = 2; lymphocyte-rich cHL and BCL-not otherwise specified, n = 1 each. GZL consensus-confirmed vs reclassified cases, respectively, more often had mediastinal disease (69% vs 41%; P = .038) and less likely more than 1 extranodal site (0% vs 25%; P = .019). With a 44-month median follow-up, 3-year progression-free survival (PFS) and overall survival for patients with confirmed GZL were 39% and 95%, respectively, vs 58% and 85%, respectively, for reclassified cases ( P = .19 and P = .15, respectively). Interestingly, NS grade 2 reclassified patients had similar PFS as GZL consensus-confirmed cases. For prognostication of GZL cases, hypoalbuminemia was a negative factor (3-year PFS, 12% vs 64%; P = .01), whereas frontline cyclophosphamide, doxorubicin, vincristine, and prednisone ± rituximab (CHOP±R) was associated with improved 3-year PFS (70% vs 20%; P = .03); both factors remained significant on multivariate analysis. Altogether, accurate diagnosis of GZL remains challenging, and improved therapeutic strategies are needed.

  14. Dose- and Time-Dependent Response of Human Leukemia (HL-60 Cells to Arsenic Trioxide Treatment

    Directory of Open Access Journals (Sweden)

    Paul B. Tchounwou

    2006-06-01

    Full Text Available The treatment of acute promyelocytic leukemia (APL has been based on the administration of all-trans retinoic acid plus anthracycline chemotherapy, which is very effective as first line therapy; however 25 to 30% of patients will relapse with their disease becoming refractory to conventional therapy. Recently, studies have shown arsenic trioxide to be effective in the treatment of acute promyelocytic leukemia. In this study, we used the human leukemia (HL-60 cell line as a model to evaluate the cytoxicity of arsenic trioxide based on the MTT assay. Data obtained from this assay indicated that arsenic trioxide significantly reduced the viability of HL-60 cells, showing LD50 values of 14.26 + 0.5μg/mL, 12.54 + 0.3μg/mL, and 6.4 + 0.6μg/mL upon 6, 12, and 24 hours of exposure, respectively; indicating a dose- and time-dependent response relationship. Findings from the present study indicate that arsenic trioxide is highly cytotoxic to human leukemia (HL-60 cells, supporting its use as an effective therapeutic agent in the management of acute promyelocytic leukemia.

  15. Ultraviolet B irradiation of human leukaemia HL-60 cells in vitro induces apoptosis

    International Nuclear Information System (INIS)

    Martin, S.J.; Cotter, T.G.

    1991-01-01

    UV radiation is known to be a potent agent for the induction of programmed cell death (apoptosis) in human skin. However, the mechanistic aspects of UV-induced apoptosis remain ill-defined. In this study the effects of varying periods of UV-irradiation on the human leukaemia HL-60 cell line and on five other human cell lines were investigated.HL-60 cells were found to rapidly undergo apoptosis en masse after short periods of UV-irradiation whereas prolonged exposure of these cells to this form of radiation induced a more rapid form of cell death which was suggestive of necrosis, the pathological mode of cell death. UV-induced apoptosis in cell lines was characterized by morphological changes as well as DNA fragmentation into unit multiples of ∼ 200 bp, which was indicative of endogenous endonuclease activation. This DNA fragmentation pattern was not detected in cells immediately after UV-irradiation, and was therefore not the result of direct UV-induced DNA damage. UV-induced apoptosis of the HL-60 cell line was found to require extracellular calcium and to be inhibited in a dose-dependent way by zinc added to the culture medium. (author)

  16. The CMS ECAL Upgrade for Precision Crystal Calorimetry at the HL-LHC

    CERN Document Server

    Marinelli, Nancy

    2017-01-01

    The Compact Muon Solenoid Experiment (CMS) is operating at the Large Hadron Collider (LHC) with proton-proton collisions at 13 TeV center-of-mass energy and at a bunch spacing of 25 ns. New further challenging running conditions for CMS are expected after the High-Luminosity upgrade of the LHC (HL--LHC). The CMS electromagnetic calorimeter (ECAL) will need to be upgraded to substain the hardned environment.The design and R\\ and D studies for the ECAL upgrade are presented together with first test beam studies. Particular challenges at HL--LHC are the harsh radiation environment, the increasing data rates and the extreme level of pile-up events, with up to 200 simultaneous proton-proton collisions. Precision timing can be exploited to reduce the effect of the pile-up. Time resolution measurementscarried out during test-beams are shown. Plans are also shown for R\\ and D for the new readout and trigger electronics, which must be upgraded due to the increased trigger and latency requirements at the HL--LHC

  17. Super and ferric: the first HL-LHC component is ready

    CERN Multimedia

    Antonella Del Rosso

    2016-01-01

    Although the actual installation phase in the tunnel will only start in 2024, the first magnet – a sextupole – of the High-Luminosity LHC (HL-LHC) is ready and working according to specifications. This first component is also rather unique as, unlike the superconducting magnets currently used in the LHC, it relies on a “superferric” heart.   An expert in the LASA Laboratory (INFN Milan, Italy) works on assembling the first sextupole corrector of the HL-LHC. (Image: INFN Milan) Although the name might sound completely unfamiliar, superferric magnets were first proposed in the 1980s as a possible solution for high-energy colliders. However, many technical problems had to be overcome before the use of superferric magnets could become a reality. In its final configuration, the HL-LHC will have 36 superferric corrector magnets, of which 4 will be quadrupoles, 8 sextupoles and 24 higher order magnets. In superferric (or “iron-dominated”) magne...

  18. Characterization of plasma current quench during disruptions at HL-2A

    Science.gov (United States)

    Zhu, Jinxia; Zhang, Yipo; Dong, Yunbo; HL-2A Team

    2017-05-01

    The most essential assumptions of physics for the evaluation of electromagnetic forces on the plasma-facing components due to a disruption-induced eddy current are characteristics of plasma current quenches including the current quench rate or its waveforms. The characteristics of plasma current quenches at HL-2A have been analyzed during spontaneous disruptions. Both linear decay and exponential decay are found in the disruptions with the fastest current quenches. However, there are two stages of current quench in the slow current quench case. The first stage with an exponential decay and the second stage followed by a rapid linear decay. The faster current quench rate corresponds to the faster movement of plasma displacement. The parameter regimes on the current quench time and the current quench rates have been obtained from disruption statistics at HL-2A. There exists no remarkable difference for distributions obtained between the limiter and the divertor configuration. This data from HL-2A provides basic data of the derivation of design criteria for a large-sized machine during the current decay phase of the disruptions.

  19. An ageing study of resistive micromegas for the HL-LHC environment

    CERN Document Server

    Galan, J.; Ferrer-Ribas, E.; Giganon, A.; Giomataris, I.; Herlant, S.; Jeanneau, F.; Peyaud, A.; Schune, Ph; Alexopoulos, T.; Byszewski, M.; Iakovidis, G.; Iengo, P.; Ntekas, K.; Leontsinis, S.; de Oliveira, R.; Tsipolitis, Y.; Wotschack, J.

    2013-01-01

    Resistive-anode micromegas detectors are in development since several years, in an effort to solve the problem of sparks when working at high flux and high ionizing radiation like in the HL-LHC (up to ten times the luminosity of the LHC). They have been chosen as one of the technologies that will be part of the ATLAS New Small Wheel project (forward muon system). An ageing study is mandatory to assess their capabilities to handle the HL-LHC environment on a long-term period. A prototype has been exposed to several types of irradiation (X-rays, cold neutrons, $^{60}$Co gammas and alphas) above the equivalent charge produced at the detector in five HL-LHC running years without showing any degradation of the performances in terms of gain and energy resolution. This study has been completed with the characterization of the tracking performances in terms of efficiency and spatial resolution, verifying the compatibility of results obtained with both resistive micromegas detectors, irradiated and non-irradiated one.

  20. Structural Analysis of Silicic Lavas Reveals the Importance of Endogenous Flow During Emplacement

    Science.gov (United States)

    Andrews, G. D.; Martens, A.; Isom, S.; Maxwell, A.; Brown, S. R.

    2017-12-01

    Recent observations of silicic lava flows in Chile strongly suggest sustained, endogeneous flow beneath an insulating carapace, where the flow advances through breakouts at the flow margin. New mapping of vertical exposures around the margin of Obsidian Dome, California, has identified discreet lobe structures in cross-section, suggesting that flow-front breakouts occured there during emplacement. The flow lobes are identified through structural measurements of flow-banding orientation and the stretching directions of vesicles. Newly acquired lidar of the Inyo Domes, including Obsidian Dome, is being analyzed to better understand the patterns of folding on the upper surface of the lavas, and to test for fold vergence patterns that may distinguish between endogenous and exogenous flow.

  1. Technical operations procedure for assembly and emplacement of the soil temperature test--test assembly

    International Nuclear Information System (INIS)

    Weber, A.P.

    1978-01-01

    A description is given of the plan for assembly, instrumentation, emplacement, and operational checkout of the soil temperature test assembly and dry well liner. The activities described cover all operations necessary to accomplish the receiving inspection, instrumentation and pre-construction handling of the dry well liner, plus all operations performed with the test article. Actual details of construction work are not covered by this procedure. Each part and/or section of this procedure is a separate function to be accomplished as required by the nature of the operation. The organization of the procedure is not intended to imply a special operational sequence or schedular requirement. Specific procedure operational sections include: receiving inspection; liner assembly operations; construction operations (by others); prepare shield plug; test article assembly and installation; and operational checkout

  2. Pre-Alleghenian (Pennsylvanian-Permian) hydrocarbon emplacement along Ordovician Knox unconformity, eastern Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    Haynes, F.M.; Kesler, S.E.

    1989-03-01

    Cores taken during exploration for Mississippi Valley-type lead and zinc ores in the Mascot-Jefferson City zinc district of eastern Tennessee commonly contain hydrocarbon residues in carbonate rocks of the Knox Group immediately below the Lower Ordovician Knox unconformity. The location and number of these residue-bearing strata reveal information about the Paleozoic history of hydrocarbon emplacement in the region. Contour maps, generated from nearly 800 holes covering more than 20 km/sup 2/, indicate that zones with elevated organic content in the uppermost 30 m of the Lower Ordovician Mascot Dolomite show a strong spatial correlation with Middle Ordovician paleotopographic highs. These same zones show no spatial association with present-day structural highs, which were formed during Pennsylvanian-Permian Alleghenian tectonism. This suggests that the physical entrapment of hydrocarbons migrating through the upper permeable units of the Mascot must have occurred prior to the principal tectonism of the Alleghenian orogeny. 7 figures, 1 table.

  3. Magnetotelluric Investigations of the Yellowstone Caldera: Understanding the Emplacement of Crustal Magma Bodies

    Science.gov (United States)

    Gurrola, R. M.; Neal, B. A.; Bennington, N. L.; Cronin, R.; Fry, B.; Hart, L.; Imamura, N.; Kelbert, A.; Bowles-martinez, E.; Miller, D. J.; Scholz, K. J.; Schultz, A.

    2017-12-01

    Wideband magnetotellurics (MT) presents an ideal method for imaging conductive shallow magma bodies associated with contemporary Yellowstone-Snake River Plain (YSRP) magmatism. Particularly, how do these magma bodies accumulate in the mid to upper crust underlying the Yellowstone Caldera, and furthermore, what role do hydrothermal fluids play in their ascent? During the summer 2017 field season, two field teams from Oregon State University and the University of Wisconsin-Madison installed forty-four wideband MT stations within and around the caldera, and using data slated for joint 3-D inversion with existing seismic data, two 2-D vertical conductivity sections of the crust and upper mantle were constructed. These models, in turn, provide preliminary insight into the emplacement of crustal magma bodies and hydrothermal processes in the YSRP region.

  4. Landsat investigations of the northern Paradox basin, Utah and Colorado: implications for radioactive waste emplacement

    Science.gov (United States)

    Friedman, Jules D.; Simpson, Shirley L.

    1978-01-01

    The first stages of a remote-sensing project on the Paradox basin, part of the USGS (U.S. Geological Survey) radioactive waste-emplacement program, consisted of a review and selection of the best available satellite scanner images to use in geomorphologic and tectonic investigations of the region. High-quality Landsat images in several spectral bands (E-2260-17124 and E-5165-17030), taken under low sun angle October 9 and 10, 1975, were processed via computer for planimetric rectification, histogram analysis, linear transformation of radiance values, and edge enhancement. A lineament map of the northern Paradox basin was subsequently compiled at 1:400,000 using the enhanced Landsat base. Numerous previously unmapped northeast-trending lineaments between the Green River and Yellowcat dome; confirmatory detail on the structural control of major segments of the Colorado, Gunnison, and Dolores Rivers; and new evidence for late Phanerozoic reactivation of Precambrian basement structures are among the new contributions to the tectonics of the region. Lineament trends appear to be compatible with the postulated Colorado lineament zone, with geophysical potential-field anomalies, and with a northeast-trending basement fault pattern. Combined Landsat, geologic, and geophysical field evidence for this interpretation includes the sinuousity of the composite Salt Valley anticline, the transection of the Moab-Spanish Valley anticline on its southeastern end by northeast-striking faults, and possible transection (?) of the Moab diapir. Similarly, northeast-trending lineaments in Cottonwood Canyon and elsewhere are interpreted as manifestations of structures associated with northeasterly trends in the magnetic and gravity fields of the La Sal Mountains region. Other long northwesterly lineaments near the western termination of the Ryan Creek fault zone. may be associated with the fault zone separating the Uncompahgre horst uplift from the Paradox basin. Implications of the

  5. Analysis of thermal-hydrologic-mechanical behavior near an emplacement drift at Yucca Mountain

    International Nuclear Information System (INIS)

    Rutqvist, Jonny; Tsang, Chin-Fu

    2002-01-01

    A coupled thermal, hydrologic and mechanical (THM) analysis is conducted to evaluate the impact of coupled THM processes on the performance of a potential nuclear waste repository at Yucca Mountain, Nevada. The analysis considers changes in rock mass porosity, permeability, and capillary pressure caused by rock deformations during drift excavation, as well as those caused by thermo-mechanically induced rock deformations after emplacement of the heat-generating waste. The analysis consists of a detailed calibration of coupled hydraulic-mechanical rock mass properties against field experiments, followed by a prediction of the coupled thermal, hydrologic, and mechanical behavior around a potential repository drift. For the particular problem studied and parameters used, the analysis indicates that the stress-induced permeability changes will be within one order of magnitude and that these permeability changes do not significantly impact the overall flow pattern around the repository drift

  6. Biographical Narratives of Encounter: The Significance of Mobility and Emplacement in Shaping Attitudes towards Difference

    Science.gov (United States)

    Sadgrove, Joanna

    2014-01-01

    This paper is located within work in urban studies about the significance of contact with difference as a means for reducing prejudice and achieving social change. Recent approaches, influenced by theories of affect, have emphasised non-conscious everyday negotiations of difference in the city. In this paper it is argued that such approaches lose sight of the significance of the subject: of the reflective judgements of ‘others’ made by individuals; of our ability to make decisions around the control of our feelings and identifications; and of the significance of personal pasts and collective histories in shaping the ways we perceive and react to encounters. Rather, this paper uses a biographical approach focusing on interviewees’ narratives of encounter. Through its attention to processes of mobility and emplacement, it contributes to debates about when contact with difference matters by highlighting the importance of everyday social normativities in the production of moral dispositions. PMID:26300566

  7. The offshore disposal of radioactive waste by drilled emplacement: A feasibility study

    International Nuclear Information System (INIS)

    Bury, M.R.C.

    1985-01-01

    This book is a report, based on a study by Taylor Woodrow Construction Limited, on the overall feasibility of the disposal of high-level radioactive waste in boreholes drilled deep into the ocean bed. The work comprises an engineering appraisal of the disposal process with a view to establishing technical and operational feasibility and providing overall cost information to enable an economic assessment to be made. Contents: Summary report; Reference criteria; Drilling operation; Transfer of radioactive waste, personnel and other supplies; Handling of radioactive waste on board; Lowering strings of canisters; Emplacement and backfilling of canisters; Preliminary design of marine platform; Retrieval of flasks or canisters lost or misplaced; Variations to the features of the lowering system; Logistics of the operation; Construction cost estimate; Operational costs; Appendix

  8. Geomorphology of crater and basin deposits - Emplacement of the Fra Mauro formation

    Science.gov (United States)

    Morrison, R. H.; Oberbeck, V. R.

    1975-01-01

    Characteristics of continuous deposits near lunar craters larger than about 1 km wide are considered, and it is concluded that (1) concentric dunes, radial ridges, and braided lineations result from deposition of the collision products of ejecta from adjacent pairs of similarly oriented secondary-crater chains and are, therefore, concentrations of secondary-crater ejecta; (2) intracrater ridges are produced within preexisting craters surrounding a fresh primary crater by ricocheting and focusing of secondary-crater ejecta from the preexisting craters' walls; and (3) secondary cratering has produced many of the structures of the continuous deposits of relatively small lunar craters and is the dominant process for emplacement of most of the radial facies of the continuous deposits of large lunar craters and basins. The percentages of Imbrium ejecta in deposits and the nature of Imbrium sculpturing are investigated.

  9. Homeless Blogs as Travelogues. Travel as a Struggle for Recognition and Emplacement

    Directory of Open Access Journals (Sweden)

    Halina Gąsiorowska

    2017-07-01

    Full Text Available Applying Clifford’s broad concept of travel, I discuss American homeless blogs as autobiographical travel writing serving the struggle for recognition of the street people. The analysed travelogues are hitchhiker Ruth Rader’s Ruthie in the Sky blog and self-made woman Brianna Karp’s Girl’s Guide to Homelessness – a memoir published on the basis of the blog bearing the same title. In the travelogues I analyse the characteristic features of a personal travel writing: travel of the self, advice for future travelers, geographic information and portrayal of society in which the travel is undertaken. I claim that homeless bloggers recounting their stories of otherness and displacement in the US contribute to (reconstructing American cultural identity their personal Self, just like many other American travelers before. Additionally, homeless blogging about homelessness is shown as the process of emplacement (Casey – the bloggers’ attempt of making themselves at home in the world.

  10. Additive Construction with Mobile Emplacement (ACME) / Automated Construction of Expeditionary Structures (ACES) Materials Delivery System (MDS)

    Science.gov (United States)

    Mueller, R. P.; Townsend, I. I.; Tamasy, G. J.; Evers, C. J.; Sibille, L. J.; Edmunson, J. E.; Fiske, M. R.; Fikes, J. C.; Case, M.

    2018-01-01

    The purpose of the Automated Construction of Expeditionary Structures, Phase 3 (ACES 3) project is to incorporate the Liquid Goods Delivery System (LGDS) into the Dry Goods Delivery System (DGDS) structure to create an integrated and automated Materials Delivery System (MDS) for 3D printing structures with ordinary Portland cement (OPC) concrete. ACES 3 is a prototype for 3-D printing barracks for soldiers in forward bases, here on Earth. The LGDS supports ACES 3 by storing liquid materials, mixing recipe batches of liquid materials, and working with the Dry Goods Feed System (DGFS) previously developed for ACES 2, combining the materials that are eventually extruded out of the print nozzle. Automated Construction of Expeditionary Structures, Phase 3 (ACES 3) is a project led by the US Army Corps of Engineers (USACE) and supported by NASA. The equivalent 3D printing system for construction in space is designated Additive Construction with Mobile Emplacement (ACME) by NASA.

  11. Verification of Vitrified High-Activity Waste Stored in a CASTOR HAW 20/28 CG Cask by Simulated Baseline Comparison

    International Nuclear Information System (INIS)

    Shephard, A.; Arenas-Carrasco, J.; Dratschmidt, H.; De-Baere, P.; Af Ekenstam, G.; Lebrun, A.

    2010-01-01

    The verification process for the vitrification of high-activity waste (HAW) focuses on maintaining the continuity-of-knowledge of special nuclear material (SNM) as it traverses a vitrification facility. However, the inaccessible nature of a vitrification facility presents an obstacle to the deployment of conventional safeguards, albeit the process area of a vitrification facility is effectively a hot cell. The employment of remotely operated NDA hardware/DA sample equipment inside the process area would be problematic-at-best and the alternative of continuous monitoring would draw heavily on the critical resource of inspector time. In response to the aforementioned constraints, the IAEA and Euratom opted to develop a new method which focuses on the verification of SNM after the vitrified HAW has been sealed in storage casks. The new method verifies the presence of the vitrified HAW through the comparison of total neutron count rates collected at points around a cask with those predicted by Monte Carlo simulation. The model includes a dual N50 neutron slab detector (custom design by Euratom) and a CASTOR HAW 20/28 CG storage cask configured with the operator declared contents. By comparison of the simulated neutron emission pattern and field measurements, the displacement of Pu and U is evident from a detectable neutron signal defect. Because the spontaneous fission of 244 Cm is the dominant neutron source in vitrified HAW, the 244 Cm/Pu and 244 Cm/U mass ratios must be known in order to relate the neutron signal outside the cask to the amounts of Pu and U stored inside. These mass ratios can be determined from HAW samples collected by the inspectorates from the accountability tanks and analyzed by DA. The absence of separation of SNM from the HAW is verified by other measures. To ensure the validity of the simulation, sources of uncertainty were systematically addressed and quantified. This new verification method effectively removes the need for NDA equipment

  12. Autoradiographic imaging of cerebral ischemia using hypoxic marker: 99mTc-HL91 in animal models

    International Nuclear Information System (INIS)

    Zhu Cansheng; Jiang Ningyi; Hu Xiaoke

    2001-01-01

    Objective: To explore the possibility of 99m Tc-HL91 imaging in detecting the ischemic penumbra during acute stoke. Methods; 16 Sprague-Dawley (SD) rats were divided into operation group (n=12) and pseudo-operation group (n=4) randomly. In operation group, 12 middle cerebral artery occlusion animal (MCAO) models were established by electrocautery. 4 rats in pseudo-operation group were treated as a control without occlusion. All animals were injected 99m Tc-HL91 intravenously 2 hours after occlusion. Animals were killed at different time after injection and brains were removed rapidly from the skull to do the autoradiographic study. Results: The ischemic territory accumulated more 99m Tc-HL91 than the opposite site in the autoradiogram at 1 hour after injection. The ischemic cerebral tissue can be visualized clearly. At 2, 4 hours after injection, the difference of accumulation of 99m Tc-HL91 in target and non-target site became more obvious. By using computer-enhanced imaging analysis, the optical density (OD) ratio differences between each subgroup of operation group and pseudo-operation group were all significant. The OD ratios (T/N) were 1.2691±0.0189, 1.3542±0.0119, 2.1201±0.0616, 2.5369±0.1214 respectively at 1, 2, 4 hours after 99m Tc-HL91 injection. Conclusion: 99m Tc-HL91 can be avidly taken up by ischemic penumbra. 99m Tc-HL91 is a potential agent for imaging hypoxic tissue, and 99m Tc-HL91 SPECT may be a promising imaging method in detecting the ischemic penumbra

  13. Field test demonstration of emplacement feasibility of precompacted clay buffer materials in a granitic medium

    International Nuclear Information System (INIS)

    Jorda, M.; Lajudie, A.; Gatabin, C.; Atabek, R.

    1992-01-01

    Field test demonstration of emplacement feasibility of precompacted clay buffer materials in a granitic medium has been successfully carried out in February 1990 at the mining centre of FANAY. SILORD site was selected allowing the drilling through the 'Raise Boring' technique of pits of 30 m depth minimum between two pre-existent galleries. Two pits of 37 m depth were drilled and characterized in detail: mean diameter and vertical deviation measurements, valuation of the surface condition (rugosity) and cracking. The pit which was the most regular was selected for the feasibility test it-self. In parallel, manufacturing and handling techniques for the engineered barrier were improved. The bricks were made from a powdered mixture of clay and 10% sand and formed the barrier which was installed in the pit using iron baskets. The technique used was compacting by uniaxial pressing at 64 MPa. Twenty eight baskets containing the engineered barrier were fabricated at LIBOS (refractory manufactory of CTE Group) and taken to FANAY-SILORD. A maximal diameter of 96.03 cm was determined for the basket passing through (basket height = 1.335 m) and verified by the lowering of basket gauges in the pit. The baskets were stacked up in the pit, without any difficulty, with a mean radial gap of 1.6 cm (for a pit mean diameter of 99.3 cm). Three simulated COGEMA waste containers were then satisfactorily installed. The real volume to be sealed, including residual voids, was estimated at 21.47 m 3 . The engineered barrier weight after emplacement came to 36280 kg leading to a dry density in service, i.e. after the engineered barrier swelling, of 1.69. 30 figs

  14. Emplacement of zero-valent metal for remediation of deep contaminant plumes

    International Nuclear Information System (INIS)

    Hubble, D.W.; Gillham, R.W.; Cherry, J.A.

    1997-01-01

    Some groundwater plumes containing chlorinated solvent contaminants are found to be so deep that current in situ remediation technologies cannot be economically applied. Also, source zones are often found to be too deep for removal or inaccessible due to surface features. Plumes emanating from these sources require containment or treatment. Containment technologies are available for shallow sites (< 15 m) and are being developed for greater depths. However, it is important to advance the science of reactive treatment - both for cut off of plumes and to contain and treat source zones. Zero-valent metal technology has been used for remediation of solvent plumes at sites in Canada, the UK and at several industrial and military sites in the USA. To date, all of the plumes treated with zero-valent metal (granular iron) have been at depths less than 15 m. This paper gives preliminary results of research into methods to emplace granular iron at depths in the range of 15 to 60 m. The study included review of available and emerging methods of installing barrier or reactive material and the selection, preliminary design and costing of several methods. The design of a treatment system for a 122 m wide PCE plume that, immediately down gradient from its source, extends from a depth of 24 to 37 m below the ground surface is used as a demonstration site. Both Permeable Reactive Wall and Funnel-and-Gate trademark systems were considered. The emplacement methods selected for preliminary design and costing were slurry wall, driven/vibrated beam, deep soil mixing and hydrofracturing injection. For each of these methods, the iron must be slurried for ease of pumping and placement using biodegradable polymer viscosifiers that leave the iron reactive

  15. The Sonju Lake layered intrusion, northeast Minnesota: Internal structure and emplacement history inferred from magnetic fabrics

    Science.gov (United States)

    Maes, S.M.; Tikoff, B.; Ferre, E.C.; Brown, P.E.; Miller, J.D.

    2007-01-01

    The Sonju Lake intrusion (SLI), in northeastern Minnesota, is a layered mafic complex of Keweenawan age (1096.1 ?? 0.8 Ma) related to the Midcontinent rift. The cumulate paragenesis of the intrusion is recognized as broadly similar to the Skaergaard intrusion, a classic example of closed-system differentiation of a tholeiitic mafic magma. The SLI represents nearly closed-system differentiation through bottom-up fractional crystallization. Geochemical studies have identified the presence of a stratabound, 50-100 m thick zone anomalously enriched in Au + PGE. Similar to the PGE reefs of the Skaergaard intrusion, this PGE-enriched zone is hosted within oxide gabbro cumulates, about two-third of the way up from the base of the intrusion. We present a petrofabric study using the anisotropy of magnetic susceptibility (AMS) to investigate the emplacement and flow patterns within the Sonju Lake intrusion. Petrographic and electron microprobe studies, combined with AMS and hysteresis measurements indicate the primary source of the magnetic signal is pseudo-single domain (PSD) magnetite or titanomagnetite. Low field AMS was measured at 32 sites within the Sonju Lake intrusion, which provided information about primary igneous fabrics. The magnetic fabrics in the layered series of the Sonju Lake intrusion are consistent with sub-horizontal to inclined emplacement of the intrusion and show evidence that the cumulate layers were deposited in a dynamic environment. Well-aligned magnetic lineations, consistently plunging shallowly toward the southwest, indicate the source of the magma is a vertical sill-like feeder, presumably located beneath the Finland granite. The Finland granite acted as a density trap for the Sonju Lake magmas, forcing lateral flow of magma to the northeast. The strongly oblate magnetic shape fabrics indicate the shallowly dipping planar fabrics were enhanced by compaction of the crystal mush. ?? 2007 Elsevier B.V. All rights reserved.

  16. Transitions in Lava Emplacement Recorded in the Deccan Traps Sequence (India)

    Science.gov (United States)

    Vanderkluysen, L.; Self, S.; Jay, A. E.; Sheth, H. C.; Clarke, A. B.

    2015-12-01

    Transitions in the style of lava flow emplacement are recognized in the stratigraphic sequence of several mafic large igneous provinces (LIPs), including the Etendeka (Namibia), the Faeroe Islands (North Atlantic LIP), the Ethiopian Traps, and the Deccan Traps (India). These transitions, from units dominated by meter-sized pāhoehoe toes and lobes to those dominated by inflated sheet lobes tens to hundreds of meters in width and meters to tens of meters in height, seems to be a fundamental feature of LIP emplacement. In the Deccan, this volcanological transition is thought to coincide with deeper changes to the volcano-magmatic system expressed, notably, in the trace element and isotopic signature of erupted flows. We investigated this transition in the Deccan Traps by logging eight sequences along the Western Ghats, an escarpment in western India where the Deccan province is thickest and best exposed. The Deccan province, which once covered ~1 million km2 of west-central India, is subdivided in eleven chemo-stratigraphic formations in the type sections of the Western Ghats. Where the lower Deccan formations are exposed, we found that as much as 65% of the exposed thickness (below the Khandala Formation) is made up of sheet lobes, from 40% in the Bhimashankar Formation to 75% in the Thakurvadi Formation. Near the bottom of the sequence, 25% of the Neral Formation is composed of sheet lobes ≥15 m in thickness. On this basis, the traditional view that inflated sheet lobes are an exclusive feature of the upper part of the stratigraphy must be challenged. Several mechanisms have been proposed to explain the development of compound flows and inflated sheet lobes, involving one or more of the following factors: underlying slope, varying effusion rate, and source geometry. Analogue experiments are currently under way to test the relative influence of each of these factors in the development of different lava flow morphologies in LIPs.

  17. Emplacement and Deformation of Mesozoic Gabbros of the High Atlas (Morocco): Paleomagnetism and Magnetic Fabrics

    Science.gov (United States)

    Calvín, P.; Ruiz-Martínez, V. C.; Villalaín, J. J.; Casas-Sainz, A. M.; Moussaid, B.

    2017-12-01

    A paleomagnetic and magnetic fabric study is performed in Upper Jurassic gabbros of the central High Atlas (Morocco). These gabbros were emplaced in the core of preexisting structures developed during the extensional stage and linked to basement faults. These structures were reactivated as anticlines during the Cenozoic compressional inversion. Gabbros from 19 out of the 33 sampled sites show a stable characteristic magnetization, carried by magnetite, which has been interpreted as a primary component. This component shows an important dispersion due to postemplacement tectonic movements. The absence of paleoposition markers in these igneous rocks precludes direct restorations. A novel approach analyzing the orientation of the primary magnetization is used here to restore the magmatic bodies and to understand the deformational history recorded by these rocks. Paleomagnetic vectors are distributed along small circles with horizontal axes, indicating horizontal axis rotations of the gabbro bodies. These rotations are higher when the ratio between shales and gabbros in the core of the anticlines increases. Due to the uncertainties inherent to this work (the igneous bodies recording strong rotations), interpretations must be qualitative. The magnetic fabric is carried by ferromagnetic (s.s.) minerals mimicking the magmatic fabric. Anisotropy of magnetic susceptibility (AMS) axes, using the rotation routine inferred from paleomagnetic results, result in more tightly clustered magnetic lineations, which also become horizontal and are considered in terms of magma flow trend during its emplacement: NW-SE (parallel to the general extensional direction) in the western sector and NE-SW (parallel to the main faults) in the easternmost structures.

  18. AN ORIGIN OF MULTIPLE RING STRUCTURE AND HIDDEN PLANETS IN HL TAU: A UNIFIED PICTURE BY SECULAR GRAVITATIONAL INSTABILITY

    International Nuclear Information System (INIS)

    Takahashi, Sanemichi Z.; Inutsuka, Shu-ichiro

    2016-01-01

    Recent ALMA observation has revealed multiple ring structures formed in a protoplanetary disk around HL Tau. Prior to the ALMA observation of HL Tau, theoretical analysis of secular gravitational instability (GI) described a possible formation of multiple ring structures with separations of 13 au around a radius of 100 au in protoplanetary disks under certain conditions. In this article, we reanalyze the viability of secular GI by adopting the physical values inferred from the observations. We derive the radial distributions of the most unstable wavelength and the growth timescale of secular GI and verify that secular GI can form the ring structures observed in HL Tau. When a turbulent viscosity coefficient α remains small in the inner region of the disk, secular GI grows in the whole disk. Thus, the formation of planetary mass objects should occur first in the inner region as a result of gravitational fragmentation after the nonlinear growth of secular GI. In this case, the resulting objects are expected to create gaps at r  ∼ 10 au and ∼30 au. As a result, all ring structures in HL Tau can be created by secular GI. If this scenario is realized in HL Tau, the outer region corresponds to the earlier growth phase of the most unstable mode of secular GI, and the inner region corresponds to the outcome of the nonlinear growth of secular GI. Therefore, this interpretation suggests that we are possibly witnessing both the beginning and the end of planet formation in HL Tau.

  19. Experimental study of 99Tcm-HL91 and 99Tcm-MIBI in mice bearing Lewis lung cancer

    International Nuclear Information System (INIS)

    Han Chunqi; Li Yaming; Ren Yangang; Yi Lijie

    2000-01-01

    Objective: To evaluate the ability of detecting lung cancer by 99 Tc m -HL91 and 99 Tc m -MIBI in mice bearing Lewis lung cancer. Methods: Four model mice underwent whole body planar imaging at 2 h, 4 h after injection of 99 Tc m -MIBI; four mice underwent whole body planar imaging at 2 h and 4 h after injection of 99 Tc m -HL91, and the mice of the 99 Tc m -HL91 group were then killed, the tumor, blood and organs were removed, weighted and the radioactivity was measured. ROIs were drawn around the tumor, head and chest in whole body planar images, and radioactivity ratios of tumor to head (T/H), chest (T/C) and contralateral limbs (T/L) were calculated. Results: No significant tumor radioactivity in 2 h and 4 h images of 99 Tc m -MIBI mice (T/C: 0.20 +- 0.08 and 0.14 +- 0.07) was found; increased tumor radioactivity was identified in images of 99 Tc m -HL91 mice (T/C: 3.25 +- 1.25 and 2.44 +- 1.07), and there was significant difference (t = 4.8 - 7.5, P 99 Tc m -HL91 in tumor tissue of mice is higher and clearance rate is slower. 99 Tc m -HL91 is a valuable tumor imaging agent for clinical diagnosis for the cancer

  20. AN ORIGIN OF MULTIPLE RING STRUCTURE AND HIDDEN PLANETS IN HL TAU: A UNIFIED PICTURE BY SECULAR GRAVITATIONAL INSTABILITY

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Sanemichi Z. [Astronomical Institute, Tohoku University, 6-3 Aoba, Aramaki-aza, Aoba-ku, Sendai, Miyagi (Japan); Inutsuka, Shu-ichiro, E-mail: sanemichi@astr.tohoku.ac.jp, E-mail: inutsuka@nagoya-u.jp [Department of Physics, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8602 (Japan)

    2016-12-01

    Recent ALMA observation has revealed multiple ring structures formed in a protoplanetary disk around HL Tau. Prior to the ALMA observation of HL Tau, theoretical analysis of secular gravitational instability (GI) described a possible formation of multiple ring structures with separations of 13 au around a radius of 100 au in protoplanetary disks under certain conditions. In this article, we reanalyze the viability of secular GI by adopting the physical values inferred from the observations. We derive the radial distributions of the most unstable wavelength and the growth timescale of secular GI and verify that secular GI can form the ring structures observed in HL Tau. When a turbulent viscosity coefficient α remains small in the inner region of the disk, secular GI grows in the whole disk. Thus, the formation of planetary mass objects should occur first in the inner region as a result of gravitational fragmentation after the nonlinear growth of secular GI. In this case, the resulting objects are expected to create gaps at r  ∼ 10 au and ∼30 au. As a result, all ring structures in HL Tau can be created by secular GI. If this scenario is realized in HL Tau, the outer region corresponds to the earlier growth phase of the most unstable mode of secular GI, and the inner region corresponds to the outcome of the nonlinear growth of secular GI. Therefore, this interpretation suggests that we are possibly witnessing both the beginning and the end of planet formation in HL Tau.

  1. Determination of emplacement mechanism of Zafarghand granitoid Pluton (Southeast of Ardestan by using anisotropy of magnetic susceptibility method (AMS

    Directory of Open Access Journals (Sweden)

    Mahmoud Sadeghian

    2017-03-01

    Full Text Available Zafarghand granitoid pluton with compositional range from gabbro to granite and early to middle Miocene age cropped out about 35 km of SE Ardestan. This pluton intrudedthe Eocene volcanic and volcanosedimentary rocks of the Urumieh - Dokhtar structuralzone. In this research, for the first time, the emplacement mechanism of Zafarghandgranitoidic pluton method has been investigated using of anisotropy of magneticsusceptibility (AMS. Based on field observations, as well as petrography andinterpretations of magnetic parameters, Zafarghand pluton divided into 5 domains (1A,1B, 2, 3, 4 and 5. Domain 1, in turn, is divided into 1A and 1B. Domains 2 and 4 arelithologically, gabbro to quartzdiorite and have been emplaced first. They have playedas feeder zones. Domains 1A, 1B, 3, and 5 are dominantly granodioritic to graniticcomposition and have been emplaced as a big and low dip magmatic flow (or possibly as a sill. The occurrence of gabbro to quartzdiorite as well as grandiorite, granite andtonalite in the margin borders of the body, are all indication of magma mixing. It isshould be noted that during emplacement of the pluton studied, fractionalcrystallization, magma mixing and crustal contamination contributed to its generationand the evolution as well.

  2. Lack of inhibiting effect of oil emplacement on quartz cementation: Evidence from Cambrian reservoir sandstones, Paleozoic Baltic Basin

    DEFF Research Database (Denmark)

    Molenaar, Nicolaas; Cyziene, Jolanta; Sliaupa, Saulius

    2008-01-01

    Currently, the question of whether or not the presence of oil in sandstone inhibits quartz cementation and preserves porosity is still debated. Data from a number of Cambrian sandstone oil fields and dry fields have been studied to determine the effects of oil emplacement on quartz cementation. T...

  3. Hanford 100-N Area In Situ Apatite and Phosphate Emplacement by Groundwater and Jet Injection: Geochemical and Physical Core Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Szecsody, James E.; Vermeul, Vincent R.; Fruchter, Jonathan S.; Williams, Mark D.; Rockhold, Mark L.; Qafoku, Nikolla; Phillips, Jerry L.

    2010-07-01

    The purpose of this study is to evaluate emplacement of phosphate into subsurface sediments in the Hanford Site 100-N Area by two different technologies: groundwater injection of a Ca-citrate-PO4 solution and water-jet injection of sodium phosphate and/or fish-bone apatite. In situ emplacement of phosphate and apatite adsorbs, then incorporates Sr-90 into the apatite structure by substitution for calcium. Overall, both technologies (groundwater injection of Ca-citrate-PO4) and water-jet injection of sodium phosphate/fish-bone apatite) delivered sufficient phosphate to subsur¬face sediments in the 100-N Area. Over years to decades, additional Sr-90 will incorporate into the apatite precipitate. Therefore, high pressure water jetting is a viable technology to emplace phosphate or apatite in shallow subsurface sediments difficult to emplace by Ca-citrate-PO4 groundwater injections, but further analysis is needed to quantify the relevant areal extent of phosphate deposition (in the 5- to 15-ft distance from injection points) and cause of the high deposition in finer grained sediments.

  4. Granitic magma emplacement and deformation during early-orogenic syn-convergent transtension: The Stare Sedlo complex, Bohemian Massif

    Czech Academy of Sciences Publication Activity Database

    Tomek, Filip; Žák, J.; Chadima, Martin

    2015-01-01

    Roč. 87, JUL (2015), s. 50-66 ISSN 0264-3707 Institutional support: RVO:67985831 Keywords : anisotropy of magnetic susceptibility (AMS) * Bohemian Massif * pluton emplacement * granite * transtension * Variscan orogeny Subject RIV: DB - Geology ; Mineralogy Impact factor: 1.926, year: 2015

  5. The importance of mobile fission products for long-term safety in the case of disposal of vitrified high-level waste and spent fuel in a clay formation

    International Nuclear Information System (INIS)

    Marivoet, J.; Weetjens, E.

    2009-01-01

    In Belgium, the possibility to dispose of high-level radioactive waste in clay formations is studied since 1976. In the PAGIS report, which was the first performance assessment of the disposal of vitrified high-level waste in a clay formation and which was published in 1988, the most important contributors to the total dose via a water well pathway were 237 Np, 135 Cs and 99 Tc. Since 1988, several elements that strongly influence the calculated doses have evolved:?the inventory of long-lived mobile fission and activation products in vitrified high-level waste has been improved; the half-life of 79 Se has been re-estimated; substantial progress has been made in the determination of migration parameters of the main fission and activation products and actinides. In recent performance assessments, the actinides and 135 Cs do not significantly contribute to the total dose, as they remain confined in the host clay formation during several millions of years due to sorption on clay minerals. Consequently, the total dose resulting from the disposal of vitrified high-level waste or spent fuel is essentially due to releases of mobile fission and activation products. On the basis of recent waste inventory data and parameter values, the most important contributors to the total dose via a water well are: in the case of disposal of spent fuel: 79 Se, 129 I, 126 Sn, 36 Cl, and 99 Tc; in the case of disposal of vitrified HLW: 79 Se, 126 Sn, 36 Cl, 129 I, and 99 Tc. Important remaining uncertainties are the transfer factors of volatile fission and activation products into the vitrified waste during reprocessing and migration parameters of Se. (author)

  6. Characteristics and mode of emplacement of gneiss domes and plutonic domes in central-eastern Pyrenees

    Science.gov (United States)

    Soula, Jean-Claude

    Gneiss domes and plutonic granitoid domes make up almost 50% of the pre-Hercynian terrains in the Central and Eastern Pyrenees. From a structural study of the shape and internal structure of the domes and of their relationships with the enclosing rocks, it can be shown that both types of domes were emplaced diapirically during the major regional deformation phase and the peak of regional metamorphism. The study also shows that the internal structure, the overall shape and general behaviour relative to the host rocks are similar for plutonic domes and for gneiss domes. This appears to be in good agreement with H. Ramberg's (1967, Gravity Deformation and the Earth's Crust. Academic Press, London; 1970, Model studies in relation to intrusion of plutonic bodies. In: Mechanisms of Igneous Intrusion (edited by Newall, G. & Rast, N.) Geol. J. Spec. Issue2, 261-286.) model studies showing that dome or mushroom-like structures, similar to those observed, develop when there is a small viscosity ratio between the rising body and its enclosing medium. This implies a high crystal content for the granitoid magma. This crystal content has been estimated by (i) calculating the viscosity and density in natural conditions from petrological data for the magma considered as a suspension, using the model and program of J. P. Carron et al. (1978 Bull Soc. géol. Fr.20, 739-744.); (ii) using the recent results of experimental deformation of partially melted granites of I. van der Molen & M. S. Paterson (1979, Contr. Miner. Petrol.70, 299-318.) and (ii) comparing the preceding results with the data obtained by deformation experiments on rocks similar to those enclosing the domes. The minimum crystal content for the development of a dome-like structure has been, thus, estimated to about 70%, i.e. a value very close to that estimated by van der Molen & Paterson (1979) to be the critical value separating the granular framework flow from suspension-like behaviour. The effect of small

  7. THE VLA VIEW OF THE HL TAU DISK: DISK MASS, GRAIN EVOLUTION, AND EARLY PLANET FORMATION

    Energy Technology Data Exchange (ETDEWEB)

    Carrasco-González, Carlos; Rodríguez, Luis F.; Galván-Madrid, Roberto [Instituto de Radioastronomía y Astrofísica UNAM, Apartado Postal 3-72 (Xangari), 58089 Morelia, Michoacán, México (Mexico); Henning, Thomas; Linz, Hendrik; Birnstiel, Til; Boekel, Roy van; Klahr, Hubert [Max-Planck-Institut für Astronomie Heidelberg, Königstuhl 17, D-69117 Heidelberg (Germany); Chandler, Claire J.; Pérez, Laura [National Radio Astronomy Observatory, P.O. Box O, 1003 Lopezville Road, Socorro, NM 87801-0387 (United States); Anglada, Guillem; Macias, Enrique; Osorio, Mayra [Instituto de Astrofísica de Andalucía (CSIC), Apartado 3004, E-18080 Granada (Spain); Flock, Mario [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Menten, Karl [Jansky Fellow of the National Radio Astronomy Observatory (United States); Testi, Leonardo [European Southern Observatory, Karl-Schwarzschild-Str. 2, D-85748 Garching bei München (Germany); Torrelles, José M. [Institut de Ciències de l’Espai (CSIC-IEEC) and Institut de Ciències del Cosmos (UB-IEEC), Martí i Franquès 1, E-08028 Barcelona (Spain); Zhu, Zhaohuan, E-mail: c.carrasco@crya.unam.mx, E-mail: l.rodriguez@crya.unam.mx, E-mail: r.galvan@crya.unam.mx, E-mail: henning@mpia.de, E-mail: linz@mpia.de [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States)

    2016-04-10

    The first long-baseline ALMA campaign resolved the disk around the young star HL Tau into a number of axisymmetric bright and dark rings. Despite the very young age of HL Tau, these structures have been interpreted as signatures for the presence of (proto)planets. The ALMA images triggered numerous theoretical studies based on disk–planet interactions, magnetically driven disk structures, and grain evolution. Of special interest are the inner parts of disks, where terrestrial planets are expected to form. However, the emission from these regions in HL Tau turned out to be optically thick at all ALMA wavelengths, preventing the derivation of surface density profiles and grain-size distributions. Here, we present the most sensitive images of HL Tau obtained to date with the Karl G. Jansky Very Large Array at 7.0 mm wavelength with a spatial resolution comparable to the ALMA images. At this long wavelength, the dust emission from HL Tau is optically thin, allowing a comprehensive study of the inner disk. We obtain a total disk dust mass of (1–3) × 10{sup −3} M {sub ⊙}, depending on the assumed opacity and disk temperature. Our optically thin data also indicate fast grain growth, fragmentation, and formation of dense clumps in the inner densest parts of the disk. Our results suggest that the HL Tau disk may be actually in a very early stage of planetary formation, with planets not already formed in the gaps but in the process of future formation in the bright rings.

  8. THE VLA VIEW OF THE HL TAU DISK: DISK MASS, GRAIN EVOLUTION, AND EARLY PLANET FORMATION

    International Nuclear Information System (INIS)

    Carrasco-González, Carlos; Rodríguez, Luis F.; Galván-Madrid, Roberto; Henning, Thomas; Linz, Hendrik; Birnstiel, Til; Boekel, Roy van; Klahr, Hubert; Chandler, Claire J.; Pérez, Laura; Anglada, Guillem; Macias, Enrique; Osorio, Mayra; Flock, Mario; Menten, Karl; Testi, Leonardo; Torrelles, José M.; Zhu, Zhaohuan

    2016-01-01

    The first long-baseline ALMA campaign resolved the disk around the young star HL Tau into a number of axisymmetric bright and dark rings. Despite the very young age of HL Tau, these structures have been interpreted as signatures for the presence of (proto)planets. The ALMA images triggered numerous theoretical studies based on disk–planet interactions, magnetically driven disk structures, and grain evolution. Of special interest are the inner parts of disks, where terrestrial planets are expected to form. However, the emission from these regions in HL Tau turned out to be optically thick at all ALMA wavelengths, preventing the derivation of surface density profiles and grain-size distributions. Here, we present the most sensitive images of HL Tau obtained to date with the Karl G. Jansky Very Large Array at 7.0 mm wavelength with a spatial resolution comparable to the ALMA images. At this long wavelength, the dust emission from HL Tau is optically thin, allowing a comprehensive study of the inner disk. We obtain a total disk dust mass of (1–3) × 10 −3 M ⊙ , depending on the assumed opacity and disk temperature. Our optically thin data also indicate fast grain growth, fragmentation, and formation of dense clumps in the inner densest parts of the disk. Our results suggest that the HL Tau disk may be actually in a very early stage of planetary formation, with planets not already formed in the gaps but in the process of future formation in the bright rings

  9. FGF-23 dysregulates calcium homeostasis and electrophysiological properties in HL-1 atrial cells.

    Science.gov (United States)

    Kao, Yu-Hsun; Chen, Yao-Chang; Lin, Yung-Kuo; Shiu, Rong-Jie; Chao, Tze-Fan; Chen, Shih-Ann; Chen, Yi-Jen

    2014-08-01

    Fibroblast growth factor (FGF)-23 is a key regulator of phosphate homeostasis. Higher FGF-23 levels are correlated with poor outcomes in cardiovascular diseases. FGF-23 can produce cardiac hypertrophy and increase intracellular calcium, which can change cardiac electrical activity. However, it is not clear whether FGF-23 possesses arrhythmogenic potential through calcium dysregulation. Therefore, the purposes of this study were to evaluate the electrophysiological effects of FGF-23 and identify the underlying mechanisms. Patch clamp, confocal microscope with Fluo-4 fluorescence, and Western blot analyses were used to evaluate the electrophysiological characteristics, calcium homeostasis and calcium regulatory proteins in HL-1 atrial myocytes with and without FGF-23 (10 and 25 ng/mL) incubation for 24 h. FGF-23 (25 ng/mL) increased L-type calcium currents, calcium transient and sarcoplasmic reticulum Ca(2+) contents in HL-1 cells. FGF-23 (25 ng/mL)-treated cells (n = 14) had greater incidences (57%, 17% and 15%, P calcium/calmodulin-dependent protein kinase IIδ and phospholamban (PLB) at threonine 17 but had similar phosphorylation extents of PLB at serine 16, total PLB and sarcoplasmic reticulum Ca(2+) -ATPase protein. Moreover, the FGF receptor inhibitor (PD173074, 10 nM), calmodulin inhibitor (W7, 5 μM) and phospholipase C inhibitor (U73122, 1 μM) attenuated the effects of FGF-23 on calcium/calmodulin-dependent protein kinase II phosphorylation. FGF-23 increases HL-1 cells arrhythmogenesis with calcium dysregulation through modulating calcium-handling proteins. © 2014 Stichting European Society for Clinical Investigation Journal Foundation.

  10. Cdc6 is a rate-limiting factor for proliferative capacity during HL60 cell differentiation

    International Nuclear Information System (INIS)

    Barkley, Laura R.; Hong, Hye Kyung; Kingsbury, Sarah R.; James, Michelle; Stoeber, Kai; Williams, Gareth H.

    2007-01-01

    The DNA replication (or origin) licensing pathway represents a critical step in cell proliferation control downstream of growth signalling pathways. Repression of origin licensing through down-regulation of the MCM licensing factors (Mcm2-7) is emerging as a ubiquitous route for lowering proliferative capacity as metazoan cells exit the cell division cycle into quiescent, terminally differentiated and senescent 'out-of-cycle' states. Using the HL60 monocyte/macrophage differentiation model system and a cell-free DNA replication assay, we have undertaken direct biochemical investigations of the coupling of origin licensing to the differentiation process. Our data show that down-regulation of the MCM loading factor Cdc6 acts as a molecular switch that triggers loss of proliferative capacity during early engagement of the somatic differentiation programme. Consequently, addition of recombinant Cdc6 protein to in vitro replication reactions restores DNA replication competence in nuclei prepared from differentiating cells. Differentiating HL60 cells over-expressing either wild-type Cdc6 or a CDK phosphorylation-resistant Cdc6 mutant protein (Cdc6A4) exhibit an extended period of cell proliferation compared to mock-infected cells. Notably, differentiating HL60 cells over-expressing the Cdc6A4 mutant fail to down-regulate Cdc6 protein levels, suggesting that CDK phosphorylation of Cdc6 is linked to its down-regulation during differentiation and the concomitant decrease in cell proliferation. In this experimental model, Cdc6 therefore plays a key role in the sequential molecular events leading to repression of origin licensing and loss of proliferative capacity during execution of the differentiation programme

  11. Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells.

    Science.gov (United States)

    Costa, Patricia Marçal da; Ferreira, Paulo Michel Pinheiro; Bolzani, Vanderlan da Silva; Furlan, Maysa; de Freitas Formenton Macedo Dos Santos, Vânia Aparecida; Corsino, Joaquim; de Moraes, Manoel Odorico; Costa-Lotufo, Letícia Veras; Montenegro, Raquel Carvalho; Pessoa, Cláudia

    2008-06-01

    Pristimerin has been shown to be cytotoxic to several cancer cell lines. In the present work, the cytotoxicity of pristimerin was evaluated in human tumor cell lines and in human peripheral blood mononuclear cells (PBMC). This work also examined the effects of pristimerin (0.4; 0.8 and 1.7 microM) in HL-60 cells, after 6, 12 and 24h of exposure. Pristimerin reduced the number of viable cells and increased number of non-viable cells in a concentration-dependent manner by tripan blue test showing morphological changes consistent with apoptosis. Nevertheless, pristimerin was not selective to cancer cells, since it inhibited PBMC proliferation with an IC50 of 0.88 microM. DNA synthesis inhibition assessed by 5-bromo-2'-deoxyuridine (BrdU) incorporation in HL-60 cells was 70% and 83% for the concentrations of 0.4 and 0.8 microM, respectively. Pristimerin (10 and 20 microM) was not able to inhibit topoisomerase I. In AO/EB (acridine orange/ethidium bromide) staining, all tested concentrations reduced the number of HL-60 viable cells, with the occurrence of necrosis and apoptosis in a concentration-dependent manner, results in agreement with trypan blue exclusion findings. The analysis of membrane integrity and internucleosomal DNA fragmentation by flow cytometry in the presence of pristimerin indicated that treated cells underwent apoptosis. The present data point to the importance of pristimerin as representative of an emerging class of potential anticancer chemicals, exhibiting an antiproliferative effect by inhibiting DNA synthesis and triggering apoptosis.

  12. HL-217, a new topical anti-angiogenic agent, inhibits retinal vascular leakage and pathogenic subretinal neovascularization in Vldlr{sup −/−} mice

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Junghyun; Kim, Chan-Sik; Jo, Kyuhyung [Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of); Cho, Yun-Seok; Kim, Hyun-Gyu; Lee, Geun-Hyeog [Research and Development Center, Hanlim Pharm. Co. Ltd., 1656-10, Seocho-dong, Seocho-gu, Seoul (Korea, Republic of); Lee, Yun Mi; Sohn, Eunjin [Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of); Kim, Jin Sook, E-mail: jskim@kiom.re.kr [Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of)

    2015-01-02

    Highlights: • HL-217 is a new synthetic topical anti-angiogenic agent. • HL-217 attenuated subretinal neovascularization in Vldlr{sup −/−} mice. • HL-217 blocked the binding of PDGF-BB to PDGFRβ. - Abstract: HL-217 is a new synthetic angiogenesis inhibitor. Platelet derived growth factor (PDGF) is a vasoactive factor and has been implicated in proliferative retinopathies. In this study, we examined the mechanism of action and efficacy of topical application of HL-217 on subretinal neovascularization in very low-density lipoprotein receptor knockout (Vldlr{sup −/−}) mice. In three-week-old male Vldlr{sup −/−} mice, HL-217 (1.5 or 3 mg/ml) was administered twice per day for 4 weeks by topical eye drop instillation. Neovascular areas were then measured. We used a protein array to evaluate the expression levels of angiogenic factors. The inhibitory effect of HL-217 on the PDGF-BB/PDGFRβ interaction was evaluated in vitro. The neovascular area in the Vldlr{sup −/−} mice was significantly reduced by HL-217. Additionally, HL-217 decreased the expression levels of PDGF-BB protein and VEGF mRNA. Moreover, HL-217 dose-dependently inhibited the PDGF-BB/PDGFRβ interaction (IC{sub 50} = 38.9 ± 0.7 μM). These results suggest that HL-217 is a potent inhibitor of PDGF-BB. HL-217, when applied topically, is an effective inhibitor of subretinal neovascularization due to its ability to inhibit the pro-angiogenic effects of PDGF-BB.

  13. HL-217, a new topical anti-angiogenic agent, inhibits retinal vascular leakage and pathogenic subretinal neovascularization in Vldlr−/− mice

    International Nuclear Information System (INIS)

    Kim, Junghyun; Kim, Chan-Sik; Jo, Kyuhyung; Cho, Yun-Seok; Kim, Hyun-Gyu; Lee, Geun-Hyeog; Lee, Yun Mi; Sohn, Eunjin; Kim, Jin Sook

    2015-01-01

    Highlights: • HL-217 is a new synthetic topical anti-angiogenic agent. • HL-217 attenuated subretinal neovascularization in Vldlr −/− mice. • HL-217 blocked the binding of PDGF-BB to PDGFRβ. - Abstract: HL-217 is a new synthetic angiogenesis inhibitor. Platelet derived growth factor (PDGF) is a vasoactive factor and has been implicated in proliferative retinopathies. In this study, we examined the mechanism of action and efficacy of topical application of HL-217 on subretinal neovascularization in very low-density lipoprotein receptor knockout (Vldlr −/− ) mice. In three-week-old male Vldlr −/− mice, HL-217 (1.5 or 3 mg/ml) was administered twice per day for 4 weeks by topical eye drop instillation. Neovascular areas were then measured. We used a protein array to evaluate the expression levels of angiogenic factors. The inhibitory effect of HL-217 on the PDGF-BB/PDGFRβ interaction was evaluated in vitro. The neovascular area in the Vldlr −/− mice was significantly reduced by HL-217. Additionally, HL-217 decreased the expression levels of PDGF-BB protein and VEGF mRNA. Moreover, HL-217 dose-dependently inhibited the PDGF-BB/PDGFRβ interaction (IC 50 = 38.9 ± 0.7 μM). These results suggest that HL-217 is a potent inhibitor of PDGF-BB. HL-217, when applied topically, is an effective inhibitor of subretinal neovascularization due to its ability to inhibit the pro-angiogenic effects of PDGF-BB

  14. Empirical Scaling Laws of Neutral Beam Injection Power in HL-2A Tokamak

    International Nuclear Information System (INIS)

    Cao Jian-Yong; Wei Hui-Ling; Liu He; Yang Xian-Fu; Zou Gui-Qing; Yu Li-Ming; Li Qing; Luo Cui-Wen; Pan Yu-Dong; Jiang Shao-Feng; Lei Guang-Jiu; Li Bo; Rao Jun; Duan Xu-Ru

    2015-01-01

    We present an experimental method to obtain neutral beam injection (NBI) power scaling laws with operating parameters of the NBI system on HL-2A, including the beam divergence angle, the beam power transmission efficiency, the neutralization efficiency and so on. With the empirical scaling laws, the estimating power can be obtained in every shot of experiment on time, therefore the important parameters such as the energy confinement time can be obtained precisely. The simulation results by the tokamak simulation code (TSC) show that the evolution of the plasma parameters is in good agreement with the experimental results by using the NBI power from the empirical scaling law. (paper)

  15. Density Limits with Different Fuelling Methods in the HL-2A Tokamak

    International Nuclear Information System (INIS)

    Yan Longwen; Zhou Yan; Chen Chengyuan; Cao Zeng; Song Xianming; Li Wei; Dong Yunbo; Hong Wenyu; Yang Qingwei; Duan Xuru

    2009-01-01

    Density limits with different fuelling methods have been compared in HL-2A, i.e. direct gas puffing and supersonic molecular beam injection (SMBI) from outer midplane, and divertor gas fuelling. The maximum densities for low current discharges are 3.4x10 19 m -3 , 4.3x10 19 m -3 and 4.7x10 19 m -3 for the 3 kinds of fuelling methods. The corresponding density ratios to Greenwald density limit are 0.9, 1.1, 1.2, respectively. The behavior of density limit disruption is analyzed as well. (magnetically confined plasma)

  16. Estimated Sensitivity for New Particle Searches at the HL-LHC

    CERN Document Server

    CMS Collaboration

    2017-01-01

    Sensitivity projections for new physics searches with 3000 $\\mathrm{fb}^{-1}$ of data anticipated at the high-luminosity LHC (HL-LHC) are presented. These results were obtained from dedicated studies performed for the ECFA 2016 upgrade workshop. Projections for heavy vector bosons (Z$'$ and W$'$) decays containing top quarks are obtained by extrapolating Run-2 results assuming scenarios with varying systematic uncertainties. Results for the dark matter and weak production of single vector-like quark searches are obtained by implementing detector performance specifications from the CMS Phase-2 technical proposal in the DELPHES simulation package.

  17. First observation of neoclassical tearing modes in the HL-2A tokamak

    International Nuclear Information System (INIS)

    Ji Xiaoquan; Yang Qingwei; Liu Yi; Zhou Jun; Feng Beibin; Yuan Baoshan

    2010-01-01

    The m/n=2/1 neoclassical tearing modes are first observed in HL-2A low density, low beta plasma with central electron cyclotron resonance heating. The neoclassical tearing modes (NTMs) are triggered by a sawtooth crash with m/n=1/1 precursors, which are toroidal coupled with a small scale m/n=2/1 mode. The time history of the island width is compared with the prediction of the NTM theory, showing a good agreement between theory and experiment. (authors)

  18. Estimates of power generated from synchrotron radiation in the HL-LHC experimental insertion regions

    CERN Document Server

    Rossi, Adriana; CERN. Geneva. ATS Department

    2017-01-01

    The power generated in single magnets of the HL-LHC experimental regions is estimated for collision optics HLLHCV1.2 β*=15 cm Round and HLLHCV1.2 Flat. Note that the layout used for the computations presented here is that before the recent change of baseline. These values should serve as input to Monte-Carlo codes (i.e., PHOTON [ ], Synrad [ ] or others), able to calculate the heat load distribution along the machine and in particular the Long Straight Sections (LSS).

  19. IN SILICO MODELLING OF CYTOTOXIC BEHAVIOUR OF ANTI-LEUKEMIC COMPOUNDS ON HL-60 CELL LINE

    Directory of Open Access Journals (Sweden)

    David Ebuka Arthur

    2016-05-01

    Full Text Available This research employs multiple linear regression technique in the modelling of some potent anti-leukemic compounds using paDEL molecular descriptor software calculator, to identify the best relationship between the chemical structure and toxicities of the anticancer datasets against some leukemic cell lines (HL-60. Statistical parameters such as Q2 and R2pred (test set were computed to validate the strength of the model, while Williams plot was used to assess its applicability domain. The mean effects of the molecular descriptors in the models were calculated to illuminate the principal properties of the molecules responsible for their cytotoxicity.

  20. Plasma behavior with molecular beam injection in the HL-1m tokamak

    International Nuclear Information System (INIS)

    Yao Lianghua; Tang Nianyi; Cui Zhengying; Xu Deming; Deng Zhongchao; Ding Xuantong; Luo Junlin; Dong Jiafu; Guo Gancheng; Yang Shikun; Cui Chenghe; Xiao Zhenggui; Liu Dequan; Chen Xiaoping; Yan Longwen; Yan Donghai; Wang Enyao; Deng Xiwen

    1999-01-01

    The authors report effect of the new fueling method of high speed molecular beam injection on Tokamak confinement improvement. The present method is an improvement of conventional gas puffing, with performance comparable to the small pellet injection in HL-1M and also to the slow pellet in ASDEX. The fact that a shallower fueling can lead to similar confinement improvement as a deep one suggests that there may exist a critical position in a Tokamak plasma such that any kind of fueling will have a better confinement as long as it can give rise to density peaking at the critical position

  1. Virtual file system on NoSQL for processing high volumes of HL7 messages.

    Science.gov (United States)

    Kimura, Eizen; Ishihara, Ken

    2015-01-01

    The Standardized Structured Medical Information Exchange (SS-MIX) is intended to be the standard repository for HL7 messages that depend on a local file system. However, its scalability is limited. We implemented a virtual file system using NoSQL to incorporate modern computing technology into SS-MIX and allow the system to integrate local patient IDs from different healthcare systems into a universal system. We discuss its implementation using the database MongoDB and describe its performance in a case study.

  2. Silicon Strip Detectors for ATLAS at the HL-LHC Upgrade

    CERN Document Server

    Hara, K; The ATLAS collaboration

    2012-01-01

    The present ATLAS silicon strip (SCT) and transition radiation (TRT) trackers will be replaced with new silicon strip detectors, as part of the Inner Tracker System (ITK), for the Phase-2 upgrade of the Large Hadron Collider, HL-LHC. We have carried out intensive R&D programs to establish radiation harder strip detectors that can survive in a radiation level up to 3000 fb-1 of integrated luminosity based on n+-on-p microstrip detector. We describe main specifications for this year’s sensor fabrication, followed by a description of possible module integration schema

  3. Scaling law of runaway electrons in the HL-1M tokamak

    International Nuclear Information System (INIS)

    Zheng Yongzhen

    2005-01-01

    Runaway confinement time in ohmic and additionally heated tokamak plasmas presents an anomalous behavior in comparison with theoretical predictions based on neoclassical models. A one-dimensional numerical including generation and loss effects for runaway electrons is used to deduce the dependence of runaway energy ε τ on runaway confinement time. The simulation results are presented in the form of a scaling law for ε τ on plasma parameters. The scaling of ε τ and therefore the runaway confinement time and runaway electron diffusivity has been studied in the HL-1M tokamak, by measuring hard X-ray spectra under different experimental conditions. (authors)

  4. Analysis of minor disruptions during current flat phase in the HL-1 device

    International Nuclear Information System (INIS)

    Yan Longwen; Shi Bingren; Zheng Yongzhen; Peng Liling; Huang Keqiang

    1991-01-01

    The phenomena of minor disruptions during current flat phase have been observed in the HL-1 device for five years. When these phenomena appear the safety factors qa are between 2.5∼4.5, and densities are between 1 x 10 13 cm -3 and 3 x 10 13 cm -3 or greater than 4 x 10 13 cm -3 . Periodic relaxation ocsillations of voltage and soft-X-rays are observed during minor disruptions. Their character and development conditions are carefully analylsed

  5. Crossing scheme and orbit correction in IR1/5 for HL-LHC

    CERN Document Server

    Fitterer, M; Giovannozzi, M; De Maria, R

    2015-01-01

    In this paper we review the orbit correction strategy and crossing scheme adjustment for the HL-LHC orbit correctors in IR1/5 in view of the new optics and layout version HLLHCV1.1. To this aim the results of the studies conducted for the previous layout HLLHCV1.0 are also presented here. The main objectives are to optimize the crossing scheme, in particular to reduce the strength of the orbit correctors at D2, and to obtain an estimate for the required strength to compensate orbit distortions due to various sources.

  6. How do giant planetary cores shape the dust disk? HL Tau system

    OpenAIRE

    Picogna, Giovanni; Kley, Wilhelm

    2015-01-01

    We are observing, thanks to ALMA, the dust distribution in the region of active planet formation around young stars. This is a powerful tool to connect observations with theoretical models and improve our understandings of the processes at play. We want to test how a multi-planetary system shapes its birth disk and study the influence of the planetary masses and particle sizes on the final dust distribution. Moreover, we apply our model to the HL Tau system in order to obtain some insights on...

  7. Inward rectifier potassium channels in the HL-1 cardiomyocyte-derived cell line.

    Science.gov (United States)

    Goldoni, Dana; Zhao, YouYou; Green, Brian D; McDermott, Barbara J; Collins, Anthony

    2010-11-01

    HL-1 is a line of immortalized cells of cardiomyocyte origin that are a useful complement to native cardiomyocytes in studies of cardiac gene regulation. Several types of ion channel have been identified in these cells, but not the physiologically important inward rectifier K(+) channels. Our aim was to identify and characterize inward rectifier K(+) channels in HL-1 cells. External Ba(2+) (100 µM) inhibited 44 ± 0.05% (mean ± s.e.m., n = 11) of inward current in whole-cell patch-clamp recordings. The reversal potential of the Ba(2+)-sensitive current shifted with external [K(+)] as expected for K(+)-selective channels. The slope conductance of the inward Ba(2+)-sensitive current increased with external [K(+)]. The apparent Kd for Ba(2+) was voltage dependent, ranging from 15 µM at -150  mV to 148 µM at -75  mV in 120  mM external K(+). This current was insensitive to 10 µM glybenclamide. A component of whole-cell current was sensitive to 150 µM 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), although it did not correspond to the Ba(2+)-sensitive component. The effect of external 1 mM Cs(+) was similar to that of Ba(2+). Polymerase chain reaction using HL-1 cDNA as template and primers specific for the cardiac inward rectifier K(ir)2.1 produced a fragment of the expected size that was confirmed to be K(ir)2.1 by DNA sequencing. In conclusion, HL-1 cells express a current that is characteristic of cardiac inward rectifier K(+) channels, and express K(ir)2.1 mRNA. This cell line may have use as a system for studying inward rectifier gene regulation in a cardiomyocyte phenotype. © 2010 Wiley-Liss, Inc.

  8. Development of plasma current waveform adjusting system ZLJ for tokamak device HL-1

    International Nuclear Information System (INIS)

    Wang Shangbing; Hu Haotian; Tang Fangqun; Zhou Yongzheng; Chu Xiuzhong; Cheng Jiashun; Gao Yunxia

    1989-12-01

    The control of some typical Tokamak discharge waveforms has been achieved by using plasma current waveform adjusting system ZLJ in the ohmic heating of HL-1. The discharge waveforms include a series of regular plasma current waveforms with various slow rising rate, such as 80 kA, 450 ms long flat-topping; 100 kA, 200 ms rising; 200 ms falt-topping and 180 kA, 400 ms slow rising etc. The design principle of the system and the initial experimental results are described

  9. Relationship between structure and antiproliferative activity of polymethoxyflavones towards HL60 cells.

    Science.gov (United States)

    Kawaii, Satoru; Ikuina, Tomoyasu; Hikima, Takeshi; Tokiwano, Tetsuo; Yoshizawa, Yuko

    2012-12-01

    As part of our continuing investigation of polymethoxyflavone (PMF) derivatives as potential anticancer substances, a series of PMF derivatives was synthesized. The synthesized compounds were evaluated for cytotoxicity against the promyelocytic leukemic HL60 cell line, and structure-activity relationship correlations were investigated along with previously isolated PMFs from the peel of king orange (Citrus nobilis). 7,3'-Dimethoxyflavone demonstrated the most potent activity among the synthetic PMFs. Consideration of correlation between the methoxylation pattern and antiproliferative activity revealed the importance of the 3'-methoxyl group and the higher degree of methoxylation on the A-ring moiety of PMFs.

  10. Research on the penetration characteristic of supersonic molecule beam on the HL-1M tokamak

    International Nuclear Information System (INIS)

    Dong Jiafu; Luo Junling; Tang Nianyi; Li Wei; Zhong Yunze; Liu Yi; Fu Binzhong; Yao Lianghua; Feng Baibing; Qin Yunwen

    2002-01-01

    In the HL-1M plasma experiments, two refueling ways, the pellet injection and the gas puffing, are usually used. In recent years, a new refueling method, the supersonic molecular beam (SMB) injection, has been developed. In this paper, the penetration characteristics of SMB has been analyzed and researched. The SMB experiments were analyzed with H α emissivity measurement. The H α emissivity distribution in the plasma was calculated from multi-channel chord emission singles by means of the asymmetry Abel inversion method

  11. Luminosity control and beam orbit stability with beta star leveling at LHC and HL-LHC

    CERN Document Server

    Gorzawski, Arkadiusz Andrzej; Wenninger, Jorg

    This thesis describes the wide subject of the luminosity leveling and its requirements for the LHC and the HL-LHC. We discuss the advantages and disadvantages of different leveling methods focusing the thesis on the beta star leveling technique. We review the beams offset build--up due to the environmental (i.e. natural ground motion) and mechanical (i.e. moving quadrupole) sources. We quantify the instrumentation requirements for the reliable and reproducible operation with small offsets at the interaction points. Last but not least, we propose a novel method for the beam offset stabilization at the collision point based on the feedback from the luminosity.

  12. A new way of soft X-ray spectrum measurement in the HL-2A tokamak

    International Nuclear Information System (INIS)

    Liao Min; Chen Liaoyuan; Song Xianying; Li Yongge; Luo Cuiwen; Pan Wei; Pan Li

    2007-01-01

    A soft X-ray spectrum measurement system is newly developed for the real-time acquisition, data processing and display of electron temperature. In this system, a personal computer with high-speed A/D acquisition card is used to obtain the original analog data and processing software is specially developed to calculate the electron temperature. Compared with PHA (Pulse Height Analyzer), the new system provides a way to set channel number and time solution by software. This method has been applied in the HL-2A tokamak experiment, and the result shows a good agreement with the electron temperature tested by other measurements. (authors)

  13. Hollow Electron Beam Collimation For HL-LHC - Effect On The Beam Core

    CERN Document Server

    Fitterer, M; Valishev, A; Bruce, R; Papadopoulou, S; Papotti, G; Pellegrini, D; Redaelli, S; Valuch, D; Wagner, J F

    2017-01-01

    Collimation with hollow electron beams or lenses (HEL) is currently one of the most promising concepts for active halo control in HL-LHC. In previous studies it has been shown that the halo can be efficiently removed with a hollow electron lens. Equally important as an efficient removal of the halo, is also to demonstrate that the core stays unperturbed. In this paper, we present a summary of the experiment at the LHC and simulations in view of the effect of the HEL on the beam core in case of a pulsed operation.

  14. The miniature optical transmitter and transceiver for the High-Luminosity LHC (HL-LHC) experiments

    International Nuclear Information System (INIS)

    Liu, C; Zhao, X; Deng, B; Gong, D; Guo, D; Li, X; Liang, F; Liu, G; Liu, T; Xiang, A C; Ye, J; Chen, J; Huang, D; Hou, S; Teng, P-K

    2013-01-01

    We present the design and test results of the Miniature optical Transmitter (MTx) and Transceiver (MTRx) for the high luminosity LHC (HL-LHC) experiments. MTx and MTRx are Transmitter Optical Subassembly (TOSA) and Receiver Optical Subassembly (ROSA) based. There are two major developments: the Vertical Cavity Surface Emitting Laser (VCSEL) driver ASIC LOCld and the mechanical latch that provides the connection to fibers. In this paper, we concentrate on the justification of this work, the design of the latch and the test results of these two modules with a Commercial Off-The-Shelf (COTS) VCSEL driver

  15. Explosive eruptive history of Pantelleria, Italy: Repeated caldera collapse and ignimbrite emplacement at a peralkaline volcano

    Science.gov (United States)

    Jordan, Nina J.; Rotolo, Silvio G.; Williams, Rebecca; Speranza, Fabio; McIntosh, William C.; Branney, Michael J.; Scaillet, Stéphane

    2018-01-01

    A new, pre-Green Tuff (46 ka) volcanic stratigraphy is presented for the peralkaline Pantelleria Volcano, Italy. New 40Ar/39Ar and paleomagnetic data are combined with detailed field studies to develop a comprehensive stratigraphic reconstruction of the island. We find that the pre-46 ka succession is characterised by eight silica-rich peralkaline (trachyte to pantellerite) ignimbrites, many of which blanketed the entire island. The ignimbrites are typically welded to rheomorphic, and are commonly associated with lithic breccias and/or pumice deposits. They record sustained radial pyroclastic density currents fed by low pyroclastic fountains. The onset of ignimbrite emplacement is typically preceded (more rarely followed) by pumice fallout with limited dispersal, and some eruptions lack any associated pumice fall deposit, suggesting the absence of tall eruption columns. Particular attention is given to the correlation of well-developed lithic breccias in the ignimbrites, interpreted as probable tracers of caldera collapses. They record as many as five caldera collapse events, in contrast to the two events reported to date. Inter-ignimbrite periods are characterised by explosive and effusive eruptions with limited dispersal, such as small pumice cones, as well as pedogenesis. These periods have similar characteristics as the current post-Green Tuff activity on the island, and, while not imminent, it is reasonable to postulate the occurrence of another ignimbrite-forming eruption sometime in the future.

  16. Alteration, age, and emplacement of the Tangihua Complex ophiolite, New Zealand

    International Nuclear Information System (INIS)

    Nicholson, K.N.; Black, P.M.; Picard, C.; Cooper, P.; Hall, C.M.; Itaya, T.

    2007-01-01

    The Tangihua Complex, New Zealand, represents an upper sequence of Late Cretaceous oceanic crustal material: massive basalt flows, pillow lavas, and dolerites. Three phases of alteration are preserved within the complex, each characterised by zeolite precipitation, which correlate to stratigraphic position. The mylonitised sole contains greenschist assemblages (c. 325 degrees C) grading upwards into the initial phase of alteration (250-300 degrees C), and is characterised by actinolite, epidote, albite, and Na-rich zeolites. This phase is cut by lower temperature veins of chlorite-smectite and Ca-rich zeolites. The final alteration phase ( + and Ca 2+ rich minerals, including apophyllite and calcite. Disruption of Ar/Ar spectra around 50 Ma correlate with rifting in the Loyalty Basin and initiation of obduction along the Loyalty-Three Kings Ridge system. We suggest that these events resulted in initial dismemberment, alteration, and movement of the ophiolite, whereas Ar/Ar plateaux at 25-35 Ma correspond to ophiolite emplacement and the last phases of alteration. (author). 49 refs., 5 figs., 3 tabs

  17. Emplacement of Xenolith Nodules in the Kaupulehu Lava Flow, Hualalai Volcano, Hawaii

    Science.gov (United States)

    Guest, J. E.; Spudis, P. D.; Greeley, R.; Taylor, G. J.; Baloga, S. M.

    1995-01-01

    The basaltic Kaupulehu 1800-1801 lava flow of Hualalai Volcano, Hawaii contains abundant ultramafic xenoliths. Many of these xenoliths occur as bedded layers of semi-rounded nodules, each thinly coated with a veneer (typically 1 mm thick) of lava. The nodule beds are analogous to cobble deposits of fluvial sedimentary systems. Although several mechanisms have been proposed for the formation of the nodule beds, it was found that, at more than one locality, the nodule beds are overbank levee deposits. The geological occurrence of the nodules, certain diagnostic aspects of the flow morphology and consideration of the inferred emplacement process indicate that the Kaupulehu flow had an exceptionally low viscosity on eruption and that the flow of the lava stream was extremely rapid, with flow velocities of at least 10 m/s (more than 40 km/h. This flow is the youngest on Hualalai Volcano and future eruptions of a similar type would pose considerable hazard to life as well as property.

  18. Thermal impact of waste emplacement and surface cooling associated with geologic disposal of nuclear waste

    Energy Technology Data Exchange (ETDEWEB)

    Wang, J.S.Y.; Mangold, D.C.; Spencer, R.K.; Tsang, C.F.

    1982-08-01

    The thermal effects associated with the emplacement of aged radioactive wastes in a geologic repository were studied, with emphasis on the following subjects: the waste characteristics, repository structure, and rock properties controlling the thermally induced effects; the current knowledge of the thermal, thermomechanical, and thermohydrologic impacts, determined mainly on the basis of previous studies that assume 10-year-old wastes; the thermal criteria used to determine the repository waste loading densities; and the technical advantages and disadvantages of surface cooling of the wastes prior to disposal as a means of mitigating the thermal impacts. The waste loading densities determined by repository designs for 10-year-old wastes are extended to older wastes using the near-field thermomechanical criteria based on room stability considerations. Also discussed are the effects of long surface cooling periods determined on the basis of far-field thermomechanical and thermohydrologic considerations. The extension of the surface cooling period from 10 years to longer periods can lower the near-field thermal impact but have only modest long-term effects for spent fuel. More significant long-term effects can be achieved by surface cooling of reprocessed high-level waste.

  19. Design of the human computer interface on the telerobotic small emplacement excavator

    International Nuclear Information System (INIS)

    Thompson, D.H.; Killough, S.M.; Burks, B.L.; Draper, J.V.

    1995-01-01

    The small emplacement excavator (SEE) is a ruggedized military vehicle with backhoe and front loader used by the U.S. Army for explosive ordinance disposal (EOD) and general utility excavation activities. This project resulted from a joint need in the U.S. Department of Energy (DOE) for a remote controlled excavator for buried waste operations and the U.S. Department of Defense for remote EOD operations. To evaluate the feasibility of removing personnel from the SEE vehicle during high-risk excavation tasks, a development and demonstration project was initiated. Development of a telerobotic SEE (TSEE) was performed by the Oak Ridge National Laboratory in a project funded jointly by the U.S. Army and the DOE. The TSEE features teleoperated driving, a telerobotic backhoe with four degrees of freedom, and a teleoperated front loader with two degrees of freedom on the bucket. Remote capabilities include driving (forward, reverse, brake, steering), power takeoff shifting to enable digging modes, deploying stabilizers, excavation, and computer system booting

  20. Thermal impact of waste emplacement and surface cooling associated with geologic disposal of nuclear waste

    International Nuclear Information System (INIS)

    Wang, J.S.Y.; Mangold, D.C.; Spencer, R.K.; Tsang, C.F.

    1982-08-01

    The thermal effects associated with the emplacement of aged radioactive wastes in a geologic repository were studied, with emphasis on the following subjects: the waste characteristics, repository structure, and rock properties controlling the thermally induced effects; the current knowledge of the thermal, thermomechanical, and thermohydrologic impacts, determined mainly on the basis of previous studies that assume 10-year-old wastes; the thermal criteria used to determine the repository waste loading densities; and the technical advantages and disadvantages of surface cooling of the wastes prior to disposal as a means of mitigating the thermal impacts. The waste loading densities determined by repository designs for 10-year-old wastes are extended to older wastes using the near-field thermomechanical criteria based on room stability considerations. Also discussed are the effects of long surface cooling periods determined on the basis of far-field thermomechanical and thermohydrologic considerations. The extension of the surface cooling period from 10 years to longer periods can lower the near-field thermal impact but have only modest long-term effects for spent fuel. More significant long-term effects can be achieved by surface cooling of reprocessed high-level waste