WorldWideScience

Sample records for empirically derived integrated

  1. EMPIRICALLY DERIVED INTEGRATED STELLAR YIELDS OF Fe-PEAK ELEMENTS

    International Nuclear Information System (INIS)

    Henry, R. B. C.; Cowan, John J.; Sobeck, Jennifer

    2010-01-01

    We present here the initial results of a new study of massive star yields of Fe-peak elements. We have compiled from the literature a database of carefully determined solar neighborhood stellar abundances of seven iron-peak elements, Ti, V, Cr, Mn, Fe, Co, and Ni, and then plotted [X/Fe] versus [Fe/H] to study the trends as functions of metallicity. Chemical evolution models were then employed to force a fit to the observed trends by adjusting the input massive star metallicity-sensitive yields of Kobayashi et al. Our results suggest that yields of Ti, V, and Co are generally larger as well as anticorrelated with metallicity, in contrast to the Kobayashi et al. predictions. We also find the yields of Cr and Mn to be generally smaller and directly correlated with metallicity compared to the theoretical results. Our results for Ni are consistent with theory, although our model suggests that all Ni yields should be scaled up slightly. The outcome of this exercise is the computation of a set of integrated yields, i.e., stellar yields weighted by a slightly flattened time-independent Salpeter initial mass function and integrated over stellar mass, for each of the above elements at several metallicity points spanned by the broad range of observations. These results are designed to be used as empirical constraints on future iron-peak yield predictions by stellar evolution modelers. Special attention is paid to the interesting behavior of [Cr/Co] with metallicity-these two elements have opposite slopes-as well as the indirect correlation of [Ti/Fe] with [Fe/H]. These particular trends, as well as those exhibited by the inferred integrated yields of all iron-peak elements with metallicity, are discussed in terms of both supernova nucleosynthesis and atomic physics.

  2. Integrated empirical ethics: loss of normativity?

    Science.gov (United States)

    van der Scheer, Lieke; Widdershoven, Guy

    2004-01-01

    An important discussion in contemporary ethics concerns the relevance of empirical research for ethics. Specifically, two crucial questions pertain, respectively, to the possibility of inferring normative statements from descriptive statements, and to the danger of a loss of normativity if normative statements should be based on empirical research. Here we take part in the debate and defend integrated empirical ethical research: research in which normative guidelines are established on the basis of empirical research and in which the guidelines are empirically evaluated by focusing on observable consequences. We argue that in our concrete example normative statements are not derived from descriptive statements, but are developed within a process of reflection and dialogue that goes on within a specific praxis. Moreover, we show that the distinction in experience between the desirable and the undesirable precludes relativism. The normative guidelines so developed are both critical and normative: they help in choosing the right action and in evaluating that action. Finally, following Aristotle, we plead for a return to the view that morality and ethics are inherently related to one another, and for an acknowledgment of the fact that moral judgments have their origin in experience which is always related to historical and cultural circumstances.

  3. Empirical data and moral theory. A plea for integrated empirical ethics.

    Science.gov (United States)

    Molewijk, Bert; Stiggelbout, Anne M; Otten, Wilma; Dupuis, Heleen M; Kievit, Job

    2004-01-01

    Ethicists differ considerably in their reasons for using empirical data. This paper presents a brief overview of four traditional approaches to the use of empirical data: "the prescriptive applied ethicists," "the theorists," "the critical applied ethicists," and "the particularists." The main aim of this paper is to introduce a fifth approach of more recent date (i.e. "integrated empirical ethics") and to offer some methodological directives for research in integrated empirical ethics. All five approaches are presented in a table for heuristic purposes. The table consists of eight columns: "view on distinction descriptive-prescriptive sciences," "location of moral authority," "central goal(s)," "types of normativity," "use of empirical data," "method," "interaction empirical data and moral theory," and "cooperation with descriptive sciences." Ethicists can use the table in order to identify their own approach. Reflection on these issues prior to starting research in empirical ethics should lead to harmonization of the different scientific disciplines and effective planning of the final research design. Integrated empirical ethics (IEE) refers to studies in which ethicists and descriptive scientists cooperate together continuously and intensively. Both disciplines try to integrate moral theory and empirical data in order to reach a normative conclusion with respect to a specific social practice. IEE is not wholly prescriptive or wholly descriptive since IEE assumes an interdepence between facts and values and between the empirical and the normative. The paper ends with three suggestions for consideration on some of the future challenges of integrated empirical ethics.

  4. Derivatives in South Africa – an empirical investigation

    Directory of Open Access Journals (Sweden)

    Stefan Schwegler

    2011-03-01

    Full Text Available This paper, which is the second of a two-part series, presents the empirical findings of testing a number of variables influencing investors’ decisions to use derivatives in their portfolios. Five variables were deemed very important by a sample of 21 experts in the financial services industry in South Africa. These were: the level of information available (including the transparency of price determination; investor’s knowledge of different derivative instruments; investor’s level of risk tolerance; the level of liquidity in the market; and investor’s knowledge of and familiarity with financial markets. Education is required to change negative sentiments regarding derivatives and more regulation is called for, especially in over-the-counter markets.

  5. An empirical, integrated forest biomass monitoring system

    Science.gov (United States)

    Kennedy, Robert E.; Ohmann, Janet; Gregory, Matt; Roberts, Heather; Yang, Zhiqiang; Bell, David M.; Kane, Van; Hughes, M. Joseph; Cohen, Warren B.; Powell, Scott; Neeti, Neeti; Larrue, Tara; Hooper, Sam; Kane, Jonathan; Miller, David L.; Perkins, James; Braaten, Justin; Seidl, Rupert

    2018-02-01

    The fate of live forest biomass is largely controlled by growth and disturbance processes, both natural and anthropogenic. Thus, biomass monitoring strategies must characterize both the biomass of the forests at a given point in time and the dynamic processes that change it. Here, we describe and test an empirical monitoring system designed to meet those needs. Our system uses a mix of field data, statistical modeling, remotely-sensed time-series imagery, and small-footprint lidar data to build and evaluate maps of forest biomass. It ascribes biomass change to specific change agents, and attempts to capture the impact of uncertainty in methodology. We find that: • A common image framework for biomass estimation and for change detection allows for consistent comparison of both state and change processes controlling biomass dynamics. • Regional estimates of total biomass agree well with those from plot data alone. • The system tracks biomass densities up to 450-500 Mg ha-1 with little bias, but begins underestimating true biomass as densities increase further. • Scale considerations are important. Estimates at the 30 m grain size are noisy, but agreement at broad scales is good. Further investigation to determine the appropriate scales is underway. • Uncertainty from methodological choices is evident, but much smaller than uncertainty based on choice of allometric equation used to estimate biomass from tree data. • In this forest-dominated study area, growth and loss processes largely balance in most years, with loss processes dominated by human removal through harvest. In years with substantial fire activity, however, overall biomass loss greatly outpaces growth. Taken together, our methods represent a unique combination of elements foundational to an operational landscape-scale forest biomass monitoring program.

  6. Radical Islamism and Migrant Integration in Denmark: An Empirical Inquiry

    Directory of Open Access Journals (Sweden)

    Dr. Marco Goli

    2011-01-01

    Full Text Available It has been suggested that alienation and failed integration may be causes of "Homegrown Radical Islamism" in Western societies. Western countries often expect that migrants and their descendants residing there as citizens will embrace or support common democratic ideals as a predicate for—or consequence of—their societal integration. Conventional wisdom suggests: "The more you associate yourself with the cherished and established goals and means, the more you will disassociate yourself from Radical Islamism," and vice versa. We believe that, quite surprisingly, an empirical test of this idea is lacking. Based on a nationally representative sample of 1,113 youth (ages 15–30 in Denmark with national ties to a"Muslim country," this study provides empirical evidence on the validity of this common assumption.

  7. Institutional Aspects of integration of Russian Empire in XIX century

    Directory of Open Access Journals (Sweden)

    Alexander N. Dubyanskiy

    2017-09-01

    Full Text Available The current situation in the world is characterized by the fact that there is another wave of changes to state borders, almost like after the second world war. Among the transforming States no classical empires, but the experience of building a large state formations can be used for understanding what needs to be done to preserve the integrity of States. This article addresses the question of institutional conditions of integration of economic space in the Russia of the XIX century. If we understand economy as "an institutionalized process" movement of material goods and transactions that link economic acts in the sphere of exchange makes this process stability and integrates it into the system companies. The authors considered promising idea Polanyi's three forms of integration or sharing that reproduce the economy as a whole, for the conducting institutional analysis of economy of the Russian Empire of the XIX century. We are talking about market exchange, redistribution (redistribution and of reciprocity (reciprocity, gift exchange. In this aspect, the Russian economy has not yet considered in the economic literature. The main method used institutional analysis and the historical method of research. The materials contained in the work, can be used to consider contemporary problems of integration of heterogeneous economic space. Found that to ensure the system coherence of the society and co-storage state, it is necessary to implement long-term goals in the form of Large projects. The authors consider such projects in the symbolic context of maintaining the legitimacy of power and, in purely economic aspect.

  8. Empirically derived climate predictability over the extratropical northern hemisphere

    Directory of Open Access Journals (Sweden)

    J. B. Elsner

    1994-01-01

    Full Text Available A novel application of a technique developed from chaos theory is used in describing seasonal to interannual climate predictability over the Northern Hemisphere (NH. The technique is based on an empirical forecast scheme - local approximation in a reconstructed phase space - for time-series data. Data are monthly 500 hPa heights on a latitude-longitude grid covering the NH from 20° N to the equator. Predictability is estimated based on the linear correlation between actual and predicted heights averaged over a forecast range of one- to twelve.month lead. The method is capable of extracting the major climate signals on this time scale including ENSO and the North Atlantic Oscillation.

  9. Student Response to Faculty Instruction (SRFI): An Empirically Derived Instrument to Measure Student Evaluations of Teaching

    Science.gov (United States)

    Beitzel, Brian D.

    2013-01-01

    The Student Response to Faculty Instruction (SRFI) is an instrument designed to measure the student perspective on courses in higher education. The SRFI was derived from decades of empirical studies of student evaluations of teaching. This article describes the development of the SRFI and its psychometric attributes demonstrated in two pilot study…

  10. Deriving Multidimensional Poverty Indicators: Methodological Issues and an Empirical Analysis for Italy

    Science.gov (United States)

    Coromaldi, Manuela; Zoli, Mariangela

    2012-01-01

    Theoretical and empirical studies have recently adopted a multidimensional concept of poverty. There is considerable debate about the most appropriate degree of multidimensionality to retain in the analysis. In this work we add to the received literature in two ways. First, we derive indicators of multiple deprivation by applying a particular…

  11. Empirically derived personality subtyping for predicting clinical symptoms and treatment response in bulimia nervosa.

    Science.gov (United States)

    Haynos, Ann F; Pearson, Carolyn M; Utzinger, Linsey M; Wonderlich, Stephen A; Crosby, Ross D; Mitchell, James E; Crow, Scott J; Peterson, Carol B

    2017-05-01

    Evidence suggests that eating disorder subtypes reflecting under-controlled, over-controlled, and low psychopathology personality traits constitute reliable phenotypes that differentiate treatment response. This study is the first to use statistical analyses to identify these subtypes within treatment-seeking individuals with bulimia nervosa (BN) and to use these statistically derived clusters to predict clinical outcomes. Using variables from the Dimensional Assessment of Personality Pathology-Basic Questionnaire, K-means cluster analyses identified under-controlled, over-controlled, and low psychopathology subtypes within BN patients (n = 80) enrolled in a treatment trial. Generalized linear models examined the impact of personality subtypes on Eating Disorder Examination global score, binge eating frequency, and purging frequency cross-sectionally at baseline and longitudinally at end of treatment (EOT) and follow-up. In the longitudinal models, secondary analyses were conducted to examine personality subtype as a potential moderator of response to Cognitive Behavioral Therapy-Enhanced (CBT-E) or Integrative Cognitive-Affective Therapy for BN (ICAT-BN). There were no baseline clinical differences between groups. In the longitudinal models, personality subtype predicted binge eating (p = 0.03) and purging (p = 0.01) frequency at EOT and binge eating frequency at follow-up (p = 0.045). The over-controlled group demonstrated the best outcomes on these variables. In secondary analyses, there was a treatment by subtype interaction for purging at follow-up (p = 0.04), which indicated a superiority of CBT-E over ICAT-BN for reducing purging among the over-controlled group. Empirically derived personality subtyping appears to be a valid classification system with potential to guide eating disorder treatment decisions. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2017; 50:506-514). © 2016 Wiley Periodicals, Inc.

  12. Kalman-predictive-proportional-integral-derivative (KPPID)

    International Nuclear Information System (INIS)

    Fluerasu, A.; Sutton, M.

    2004-01-01

    With third generation synchrotron X-ray sources, it is possible to acquire detailed structural information about the system under study with time resolution orders of magnitude faster than was possible a few years ago. These advances have generated many new challenges for changing and controlling the state of the system on very short time scales, in a uniform and controlled manner. For our particular X-ray experiments on crystallization or order-disorder phase transitions in metallic alloys, we need to change the sample temperature by hundreds of degrees as fast as possible while avoiding over or under shooting. To achieve this, we designed and implemented a computer-controlled temperature tracking system which combines standard Proportional-Integral-Derivative (PID) feedback, thermal modeling and finite difference thermal calculations (feedforward), and Kalman filtering of the temperature readings in order to reduce the noise. The resulting Kalman-Predictive-Proportional-Integral-Derivative (KPPID) algorithm allows us to obtain accurate control, to minimize the response time and to avoid over/under shooting, even in systems with inherently noisy temperature readings and time delays. The KPPID temperature controller was successfully implemented at the Advanced Photon Source at Argonne National Laboratories and was used to perform coherent and time-resolved X-ray diffraction experiments.

  13. Human reliability under sleep deprivation: Derivation of performance shaping factor multipliers from empirical data

    International Nuclear Information System (INIS)

    Griffith, Candice D.; Mahadevan, Sankaran

    2015-01-01

    This paper develops a probabilistic approach that could use empirical data to derive values of performance shaping factor (PSF) multipliers for use in quantitative human reliability analysis (HRA). The proposed approach is illustrated with data on sleep deprivation effects on performance. A review of existing HRA methods reveals that sleep deprivation is not explicitly included at present, and expert opinion is frequently used to inform HRA model multipliers. In this paper, quantitative data from empirical studies regarding the effect of continuous hours of wakefulness on performance measures (reaction time, accuracy, and number of lapses) are used to develop a method to derive PSF multiplier values for sleep deprivation, in the context of the SPAR-H model. Data is extracted from the identified studies according to the meta-analysis research synthesis method and used to investigate performance trends and error probabilities. The error probabilities in test and control conditions are compared, and the resulting probability ratios are suggested for use in informing the selection of PSF multipliers in HRA methods. Although illustrated for sleep deprivation, the proposed methodology is general, and can be applied to other performance shaping factors. - Highlights: • Method proposed to derive performance shaping factor multipliers from empirical data. • Studies reporting the effect of sleep deprivation on performance are analyzed. • Test data using psychomotor vigilance tasks are analyzed. • Error probability multipliers computed for reaction time, lapses, and accuracy measures.

  14. On Integrating Student Empirical Software Engineering Studies with Research and Teaching Goals

    NARCIS (Netherlands)

    Galster, Matthias; Tofan, Dan; Avgeriou, Paris

    2012-01-01

    Background: Many empirical software engineering studies use students as subjects and are conducted as part of university courses. Aim: We aim at reporting our experiences with using guidelines for integrating empirical studies with our research and teaching goals. Method: We document our experience

  15. An Empirical Analysis of Post-Merger Organizational Integration

    DEFF Research Database (Denmark)

    Smeets, Valerie Anne Rolande; Ierulli, Kathryn; Gibbs, Michael

    2016-01-01

    existing establishments. Worker turnover is high after merger, but new hiring yields stable total employment. Target employees have higher turnover and reassignment, particularly if the target firm is small relative to the acquiring firm. These findings may suggest integration is costly, but can......We study post-merger organizational integration using linked employer-employee data. Integration is implemented by reassigning a small number of high skilled workers, especially in R&D and management. Workforce mixing is concentrated to establishments set up after merger rather than to previously...... be achieved by focusing on key employees. Alternatively, reassigning a few key employees is sufficient for achieving integration....

  16. Integrated Moral Conviction Theory of Student Cheating: An Empirical Test

    Science.gov (United States)

    Roberts, Foster; Thomas, Christopher H.; Novicevic, Milorad M.; Ammeter, Anthony; Garner, Bart; Johnson, Paul; Popoola, Ifeoluwa

    2018-01-01

    In this article, we develop an "integrated moral conviction theory of student cheating" by integrating moral conviction with (a) the dual-process model of Hunt-Vitell's theory that gives primacy to individual ethical philosophies when moral judgments are made and (b) the social cognitive conceptualization that gives primacy to moral…

  17. An Empirically Derived Taxonomy for Personality Diagnosis: Bridging Science and Practice in Conceptualizing Personality

    Science.gov (United States)

    Westen, Drew; Shedler, Jonathan; Bradley, Bekh; DeFife, Jared A.

    2013-01-01

    Objective The authors describe a system for diagnosing personality pathology that is empirically derived, clinically relevant, and practical for day-to-day use. Method A random national sample of psychiatrists and clinical psychologists (N=1,201) described a randomly selected current patient with any degree of personality dysfunction (from minimal to severe) using the descriptors in the Shedler-Westen Assessment Procedure–II and completed additional research forms. Results The authors applied factor analysis to identify naturally occurring diagnostic groupings within the patient sample. The analysis yielded 10 clinically coherent personality diagnoses organized into three higher-order clusters: internalizing, externalizing, and borderline-dysregulated. The authors selected the most highly rated descriptors to construct a diagnostic prototype for each personality syndrome. In a second, independent sample, research interviewers and patients’ treating clinicians were able to diagnose the personality syndromes with high agreement and minimal comorbidity among diagnoses. Conclusions The empirically derived personality prototypes described here provide a framework for personality diagnosis that is both empirically based and clinically relevant. PMID:22193534

  18. An Empirical Analysis of Post-Merger Organizational Integration

    OpenAIRE

    Smeets, Valerie Anne Rolande; Gibbs, Michael; Ierulli, Kathryn

    2015-01-01

    We study post-merger organizational integration using linked employer-employee data. Integration is implemented by reassigning a small number of high skilled workers, especially in R&D and management. Workforce mixing is concentrated to establishments set up after merger rather than to previously existing establishments. Worker turnover is high after merger, but new hiring yields stable total employment. Target employees have higher turnover and reassignment, particularly if the target fi...

  19. SU-F-BRD-07: Empirical Derivation of Site-Specific Margin Formulas

    International Nuclear Information System (INIS)

    Conroy, L; Smith, W; Quirk, S

    2014-01-01

    Purpose: To empirically derive margin formulas from existing clinical radiotherapy plans accounting for respiratory motion and setup uncertainties. Methods: We simulated realistic treatment scenarios, including respiratory motion and setup errors. Individual probability density functions (PDF) from respiratory data were used to simulate respiratory motion. Random (σ) and systematic (Σ) setup errors were modeled as Gaussian distributions. One-dimensional dose profiles were extracted from existing radiotherapy plans and convolved with respiratory PDFs and random error distributions to produce blurred dose profiles. Each blurred dose profile was then shifted 1000 times by randomly sampling the simulated systematic error distribution. Margins were determined from the distance between the simulated treatment and the original 95% isodose level. An equation was fit for each (σ, Σ) combination to derive margin formulas for 90% of the population receiving 95% dose. This methodology can be applied to different tumor sites. Here, dose profiles were extracted from partial breast 3DCRT plans in the anterior-posterior (AP) and superior-inferior (SI) directions. Respiratory motion data was from healthy volunteers, and a clinically relevant range of random and systematic setup errors (standard deviations 1 – 4 mm) was determined from the literature. Results: The PBI margin formulas in the AP and SI directions for 95% dose coverage for 90% of the population were very similar: M= 0.68σ + 1.54Σ and M= 0.72σ + 1.50Σ, respectively. Systematic setup errors had the largest influence on required margin size, whereas realistic respiratory amplitude had minimal impact. The derived formulas resulted in a smaller systematic component than commonly-used theoretical margin recipes. Conclusion: We have demonstrated a method to derive empirical margin formulas from existing patient radiotherapy plans, incorporating realistic respiratory motion and appropriate ranges of random and

  20. Minimal variance hedging of natural gas derivatives in exponential Lévy models: Theory and empirical performance

    International Nuclear Information System (INIS)

    Ewald, Christian-Oliver; Nawar, Roy; Siu, Tak Kuen

    2013-01-01

    We consider the problem of hedging European options written on natural gas futures, in a market where prices of traded assets exhibit jumps, by trading in the underlying asset. We provide a general expression for the hedging strategy which minimizes the variance of the terminal hedging error, in terms of stochastic integral representations of the payoffs of the options involved. This formula is then applied to compute hedge ratios for common options in various models with jumps, leading to easily computable expressions. As a benchmark we take the standard Black–Scholes and Merton delta hedges. We show that in natural gas option markets minimal variance hedging with underlying consistently outperform the benchmarks by quite a margin. - Highlights: ► We derive hedging strategies for European type options written on natural gas futures. ► These are tested empirically using Henry Hub natural gas futures and options data. ► We find that our hedges systematically outperform classical benchmarks

  1. Semi-Empirical Predictions on the Structure and Properties of ent-Kaurenoic Acid and Derivatives

    Directory of Open Access Journals (Sweden)

    Jose Isagani B. Janairo

    2011-01-01

    Full Text Available The physicochemical properties of ent- kaurenoic acid model derivatives, which possibly influence its therapeutic application, were calculated. Results revealed that the molecule possess favourable attributes which renders it possible to be considered as a drug lead only that its very hydrophobic nature can result to poor bioavailabilty, low absorption and poor systemic circulation. In silico simulations revealed that this setback can be overcome by introduction of hydroxyl group to the tertiary carbon of ent-kaurenoic acid employing m-CPBA catalyzed hydroxylation, thus, unleashing its full drug potency. Moreover, molecular similarity analyses derived from semi-empirical calculations between ent-kaurenoic acid and a set of kaurane diterpenoids showed differences in hydrophobic complementarity, size and electronic properties despite possessing nearly identical molecular frameworks, thus, arriving in a generalization for their observed mechanistic differences on acting on different targets.

  2. The performance of selected semi-empirical and DFT methods in studying C60 fullerene derivatives

    Science.gov (United States)

    Sikorska, Celina; Puzyn, Tomasz

    2015-11-01

    The capability of reproducing the open circuit voltages (V oc) of 15 representative C60 fullerene derivatives was tested using the selected quantum mechanical methods (B3LYP, PM6, and PM7) together with the two one-electron basis sets. Certain theoretical treatments (e.g. PM6) were found to be satisfactory for preliminary estimates of the open circuit voltages (V oc), whereas the use of the B3LYP/6-31G(d) approach has been proven to assure highly accurate results. We also examined the structural similarity of 19 fullerene derivatives by employing principle component analysis (PCA). In order to express the structural features of the studied compounds we used molecular descriptors calculated with semi-empirical (PM6 and PM7) and density functional (B3LYP/6-31G(d)) methods separately. In performing PCA, we noticed that semi-empirical methods (i.e. PM6 and PM7) seem satisfactory for molecules, in which one can distinguish the aromatic and the aliphatic parts in the cyclopropane ring of PCBM (phenyl-C61-buteric acid methyl ester) and they significantly overestimate the energy of the highest occupied molecular orbital (E HOMO). The use of the B3LYP functional, however, is recommended for studying methanofullerenes, which closely resemble the structure of PCBM, and for their modifications.

  3. The performance of selected semi-empirical and DFT methods in studying C60 fullerene derivatives

    International Nuclear Information System (INIS)

    Sikorska, Celina; Puzyn, Tomasz

    2015-01-01

    The capability of reproducing the open circuit voltages (V oc ) of 15 representative C 60 fullerene derivatives was tested using the selected quantum mechanical methods (B3LYP, PM6, and PM7) together with the two one-electron basis sets. Certain theoretical treatments (e.g. PM6) were found to be satisfactory for preliminary estimates of the open circuit voltages (V oc ), whereas the use of the B3LYP/6-31G(d) approach has been proven to assure highly accurate results. We also examined the structural similarity of 19 fullerene derivatives by employing principle component analysis (PCA). In order to express the structural features of the studied compounds we used molecular descriptors calculated with semi-empirical (PM6 and PM7) and density functional (B3LYP/6-31G(d)) methods separately. In performing PCA, we noticed that semi-empirical methods (i.e. PM6 and PM7) seem satisfactory for molecules, in which one can distinguish the aromatic and the aliphatic parts in the cyclopropane ring of PCBM (phenyl-C 61 -buteric acid methyl ester) and they significantly overestimate the energy of the highest occupied molecular orbital (E HOMO ). The use of the B3LYP functional, however, is recommended for studying methanofullerenes, which closely resemble the structure of PCBM, and for their modifications. (paper)

  4. IMMIGRANTS’ INTEGRATION IN GREEK SOCIETY: AN EMPIRICAL RESEARCH

    Directory of Open Access Journals (Sweden)

    Anastasios Karasavvoglou

    2011-01-01

    Full Text Available Since the beginning of the 90s, Greece has rapidly become a reception country of a significant number of immigrants. It is estimated that, nowadays, the number of immigrants, both legal and illegal, is approximately 1,2 million. At the same time, Greece is, moreover, being used as an intermediate, temporary station in the immigrants’ effort to reach the countries of the central Europe. Consequently, the existing migration stock of Greece is too significant to be left unexamined, especially since various previous researches indicate that a considerable number of immigrants express their intention to make Greece their place of permanent residence. Therefore, the application of an integration immigration policy in Greek society is considered to be a necessity and the examination of the parameters that will support its effectiveness rises as an important practical issue.

  5. Patterns of alcohol use and consequences among empirically derived sexual minority subgroups.

    Science.gov (United States)

    Talley, Amelia E; Sher, Kenneth J; Steinley, Douglas; Wood, Phillip K; Littlefield, Andrew K

    2012-03-01

    The current study develops an empirically determined classification of sexual orientation developmental patterns based on participants' annual reports of self-identifications, sexual attractions, and sexual behaviors during the first 4 years of college. A secondary aim of the current work was to examine trajectories of alcohol involvement among identified subgroups. Data were drawn from a subsample of a longitudinal study of incoming first-time college students at a large, public university (n = 2,068). Longitudinal latent class analysis was used to classify sexual minority participants into empirically derived subgroups based on three self-reported facets of sexual orientation. Multivariate repeated-measures analyses were conducted to examine how trajectories of alcohol involvement varied by sexual orientation class membership. Four unique subclasses of sexual orientation developmental patterns were identified for males and females: one consistently exclusively heterosexual group and three sexual minority groups. Despite generally similar alcohol use patterns among subclasses, certain sexual minority subgroups reported elevated levels of alcohol-related negative consequences and maladaptive motivations for use throughout college compared with their exclusively heterosexual counterparts. Elevations in coping and conformity motivations for alcohol use were seen among those subgroups that also evidenced heightened negative alcohol-related consequences. Implications and limitations of the current work are discussed.

  6. What determines crime rates? An empirical test of integrated economic and sociological theories of criminal behavior

    NARCIS (Netherlands)

    Engelen, Peter Jan; Lander, Michel W.; van Essen, Marc

    Research on crime has by no means reached a definitive conclusion on which factors are related to crime rates. We contribute to the crime literature by providing an integrated empirical model of economic and sociological theories of criminal behavior and by using a very comprehensive set of

  7. Behavioural processes in marketing channel relationships: Review and integration of empirical evidence

    DEFF Research Database (Denmark)

    Jensen, Nils Bøgelund; Skytte, Hans

    1997-01-01

    This paper reviews the empirical research on behavioural processes in marketing channel relationships. Systematically examining nine international journals, we find 49 papers on behavioural processes. On the basis of the hypothesis tests in the papers, we discuss the results and integrate...

  8. Understanding Adoptive Families: An Integrative Review of Empirical Research and Future Directions for Counseling Psychology

    Science.gov (United States)

    O'Brien, Karen M.; Zamostny, Kathy P.

    2003-01-01

    Contrary to societal stereotypes about adoption, this integrative review of published empirical research on adoptive families noted several positive and few negative out-comes with regard to satisfaction with the adoption, familial functioning, and parent-child communication. The critical analysis of 38 studies on adoptive families revealed a…

  9. Computational optogenetics: empirically-derived voltage- and light-sensitive channelrhodopsin-2 model.

    Directory of Open Access Journals (Sweden)

    John C Williams

    Full Text Available Channelrhodospin-2 (ChR2, a light-sensitive ion channel, and its variants have emerged as new excitatory optogenetic tools not only in neuroscience, but also in other areas, including cardiac electrophysiology. An accurate quantitative model of ChR2 is necessary for in silico prediction of the response to optical stimulation in realistic tissue/organ settings. Such a model can guide the rational design of new ion channel functionality tailored to different cell types/tissues. Focusing on one of the most widely used ChR2 mutants (H134R with enhanced current, we collected a comprehensive experimental data set of the response of this ion channel to different irradiances and voltages, and used these data to develop a model of ChR2 with empirically-derived voltage- and irradiance- dependence, where parameters were fine-tuned via simulated annealing optimization. This ChR2 model offers: 1 accurate inward rectification in the current-voltage response across irradiances; 2 empirically-derived voltage- and light-dependent kinetics (activation, deactivation and recovery from inactivation; and 3 accurate amplitude and morphology of the response across voltage and irradiance settings. Temperature-scaling factors (Q10 were derived and model kinetics was adjusted to physiological temperatures. Using optical action potential clamp, we experimentally validated model-predicted ChR2 behavior in guinea pig ventricular myocytes. The model was then incorporated in a variety of cardiac myocytes, including human ventricular, atrial and Purkinje cell models. We demonstrate the ability of ChR2 to trigger action potentials in human cardiomyocytes at relatively low light levels, as well as the differential response of these cells to light, with the Purkinje cells being most easily excitable and ventricular cells requiring the highest irradiance at all pulse durations. This new experimentally-validated ChR2 model will facilitate virtual experimentation in neural and

  10. Corporate interest rate risk management with derivatives in Australia: empirical results

    Directory of Open Access Journals (Sweden)

    Luiz Augusto Ferreira Carneiro

    2008-04-01

    Full Text Available Financial and insurance theories explain that large widely-held corporations manage corporate risks if doing so is costective to reduce frictional costs such as taxes, agency costs and financial distress costs. A large number of previous empirical studies, most in the U.S., have tested the hypotheses underlying corporate risk management with financial derivative instruments. In order to quantify corporate hedge demand, most previous studies have used the ratio of principal notional amount of derivatives to company size, although they recognize that company size is not an appropriate proxy for financial risk. This paper analyzes the interest-rate-risk hedge demand by Australian companies, measured through the ratio of principal notional amount of interest rate derivatives to interest-rate-riskbearing liabilities. Modern panel data methods are used, with two panel data sets from 1998 to 2003 (1102 and 465 observations, respectively. Detailed information about interest-rate-risk exposures was available after manual data collection from financial annual reports, which was only possible due to specific reporting requirements in Australian accounting standards. Regarding the analysis of the extent of hedge, our measurement of interest-rate-risk exposures generates some significant results di erent from those found in previous studies. For example, this study shows that total leverage (total debt ratio is not significantly important to interest-rate-risk hedge demand and that, instead, this demand is related to the specific risk exposure in the interest bearing part of the firms liabilities. This study finds significant relations of interest-rate-risk hedge to company size, floating-interest-rate debt ratio, annual log returns, and company industry type (utilities and non-banking financial institutions.

  11. Empirically Derived and Simulated Sensitivity of Vegetation to Climate Across Global Gradients of Temperature and Precipitation

    Science.gov (United States)

    Quetin, G. R.; Swann, A. L. S.

    2017-12-01

    Successfully predicting the state of vegetation in a novel environment is dependent on our process level understanding of the ecosystem and its interactions with the environment. We derive a global empirical map of the sensitivity of vegetation to climate using the response of satellite-observed greenness and leaf area to interannual variations in temperature and precipitation. Our analysis provides observations of ecosystem functioning; the vegetation interactions with the physical environment, across a wide range of climates and provide a functional constraint for hypotheses engendered in process-based models. We infer mechanisms constraining ecosystem functioning by contrasting how the observed and simulated sensitivity of vegetation to climate varies across climate space. Our analysis yields empirical evidence for multiple physical and biological mediators of the sensitivity of vegetation to climate as a systematic change across climate space. Our comparison of remote sensing-based vegetation sensitivity with modeled estimates provides evidence for which physiological mechanisms - photosynthetic efficiency, respiration, water supply, atmospheric water demand, and sunlight availability - dominate the ecosystem functioning in places with different climates. Earth system models are generally successful in reproducing the broad sign and shape of ecosystem functioning across climate space. However, this general agreement breaks down in hot wet climates where models simulate less leaf area during a warmer year, while observations show a mixed response but overall more leaf area during warmer years. In addition, simulated ecosystem interaction with temperature is generally larger and changes more rapidly across a gradient of temperature than is observed. We hypothesize that the amplified interaction and change are both due to a lack of adaptation and acclimation in simulations. This discrepancy with observations suggests that simulated responses of vegetation to

  12. Performance Sustainability and Integrated Reporting: Empirical Evidence from Mandatory and Voluntary Adoption Contexts

    Directory of Open Access Journals (Sweden)

    Salvatore Loprevite

    2018-04-01

    Full Text Available This paper looks at the topic of regulation of integrated reporting for listed companies, with the aim of contributing to the debate on the usefulness of introducing a mandatory regime, both from the perspective of integrated performance sustainability of companies and from that of relevance of information for providers of financial capital. The study is based on empirical research carried out on a sample composed of companies operating in territories where the adoption of integrated reporting is voluntary (Europe and those operating in a country where adoption is mandatory (South Africa. The research shows that (a in voluntary regimes, levels of integrated performance achieved by companies are higher; (b mandatory regulation produces positive effects on integrated performance levels in the medium term; (c integrated performance indicators are value-relevant, though having different levels of relevance under the two regimes examined.

  13. Integrating technology readiness into the expectation-confirmation model: an empirical study of mobile services.

    Science.gov (United States)

    Chen, Shih-Chih; Liu, Ming-Ling; Lin, Chieh-Peng

    2013-08-01

    The aim of this study was to integrate technology readiness into the expectation-confirmation model (ECM) for explaining individuals' continuance of mobile data service usage. After reviewing the ECM and technology readiness, an integrated model was demonstrated via empirical data. Compared with the original ECM, the findings of this study show that the integrated model may offer an ameliorated way to clarify what factors and how they influence the continuous intention toward mobile services. Finally, the major findings are summarized, and future research directions are suggested.

  14. Pay-What-You-Want pricing: An integrative review of the empirical research literature

    Directory of Open Access Journals (Sweden)

    Torsten J.

    2017-01-01

    Full Text Available In a Pay What You Want (PWYW setting companies empower their customers to fix the prices buyers voluntarily pay for a delivered product or service. The seller agrees to any price (includ-ing zero customers are paying. For about ten years researchers empirically investigate customer reactions to and economic outcomes of this pricing method. The present paper distinguishes PWYW from other voluntary payment mechanisms and reviews 72 English- or German-speaking PWYW publications, which appeared between January 2006 and September 2016 and contain 97 independent empirical data sets. Prior PWYW research is structured with the help of a conceptual framework which incorporates payment procedure design, buyer, seller, focal sales object and market context characteristics as factors potentially influencing customer perceptions of the PWYW scheme and their behavioral reactions to PWYW offers. The review discusses both consistent key findings as well as contradictory results and derives recommendations for future empirical PWYW research efforts.

  15. International Financial Integration and Economic Growth in India: An Empirical Investigation

    Directory of Open Access Journals (Sweden)

    Nayia MAHAJAN

    2015-11-01

    Full Text Available This study endeavors to estimate relationship between international financial integration and economic growth in India during 1981-2011. Apart from direct impact of international financial integration on growth, indirect impact (via financial development has also been studied empirically. Models of co-integration and Vector Error Correction Model (VECM have been applied to examine the relationships. The study observes that international financial integration affects the growth of the economy positively; and change in economic growth due to it through financial development is approximately 8.63 percent. The study also suggests that the structural reforms that took place in India in early nineties did not affect the existing relationship of global financial integration and economic growth significantly.

  16. Empirically Derived Lessons Learned about What Makes Peer-Led Exercise Groups Flourish.

    Science.gov (United States)

    Fletcher, Kathlyn E; Ertl, Kristyn; Ruffalo, Leslie; Harris, LaTamba; Whittle, Jeff

    2017-01-01

    Physical exercise confers many health benefits, but it is difficult to motivate people to exercise. Although community exercise groups may facilitate initiation and persistence in an exercise program, reports regarding factors that allow such groups to flourish are limited. We performed a prospective qualitative evaluation of our experience starting a program of community-based, peer-led exercise groups for military veterans to identify important lessons learned. We synthesized data from structured observations, post-observation debriefings, and focus groups. Our participants were trained peer leaders and exercise group members. Our main outcomes consisted of empirically derived lessons learned during the implementation of a peer-led group exercise program for veterans at multiple community sites. We collected and analyzed data from 40 observation visits (covering 14 sites), 7 transcribed debriefings, and 5 focus groups. We identified five lessons learned. (1) The camaraderie and social aspect of the exercise groups provided motivation for people to stay involved. (2) Shared responsibility and commitment to each other by the group members was instrumental to success. (3) Regular meeting times encouraged participation. (4) Variety, especially getting outdoors, was very popular for some groups. (5) Modest involvement of professionals encouraged ongoing engagement with the program. Both social and programmatic issues influence implementation of group exercise programs for older, predominantly male, veterans. These results should be confirmed in other settings.

  17. Testing an empirically derived mental health training model featuring small groups, distributed practice and patient discussion.

    Science.gov (United States)

    Murrihy, Rachael C; Byrne, Mitchell K; Gonsalvez, Craig J

    2009-02-01

    Internationally, family doctors seeking to enhance their skills in evidence-based mental health treatment are attending brief training workshops, despite clear evidence in the literature that short-term, massed formats are not likely to improve skills in this complex area. Reviews of the educational literature suggest that an optimal model of training would incorporate distributed practice techniques; repeated practice over a lengthy time period, small-group interactive learning, mentoring relationships, skills-based training and an ongoing discussion of actual patients. This study investigates the potential role of group-based training incorporating multiple aspects of good pedagogy for training doctors in basic competencies in brief cognitive behaviour therapy (BCBT). Six groups of family doctors (n = 32) completed eight 2-hour sessions of BCBT group training over a 6-month period. A baseline control design was utilised with pre- and post-training measures of doctors' BCBT skills, knowledge and engagement in BCBT treatment. Family doctors' knowledge, skills in and actual use of BCBT with patients improved significantly over the course of training compared with the control period. This research demonstrates preliminary support for the efficacy of an empirically derived group training model for family doctors. Brief CBT group-based training could prove to be an effective and viable model for future doctor training.

  18. Examining the Stability of "DSM-IV" and Empirically Derived Eating Disorder Classification: Implications for "DSM-5"

    Science.gov (United States)

    Peterson, Carol B.; Crow, Scott J.; Swanson, Sonja A.; Crosby, Ross D.; Wonderlich, Stephen A.; Mitchell, James E.; Agras, W. Stewart; Halmi, Katherine A.

    2011-01-01

    Objective: The purpose of this investigation was to derive an empirical classification of eating disorder symptoms in a heterogeneous eating disorder sample using latent class analysis (LCA) and to examine the longitudinal stability of these latent classes (LCs) and the stability of DSM-IV eating disorder (ED) diagnoses. Method: A total of 429…

  19. QUALITY MANAGEMENT AND INTEGRATED TOTAL QUALITY IN SPANISH MINING: RESULTS OF AN EMPIRICAL STUDY

    OpenAIRE

    ESCANCIANO, CARMEN; IGLESIAS-RODRÍGUEZ, FRANCISCO-JAVIER

    2012-01-01

    This paper presents the results of an empirical study conducted in Spain among mining companies that hold ISO 9001 certification. This study aimed at reflecting upon quality management in Spanish mining; and discovering whether the certification of a quality management system provides companies with a framework for integrating total quality management with other management systems, such as environmental management or occupational health and safety management. En este artículo se presentan ...

  20. Semi-Empirical Calibration of the Integral Equation Model for Co-Polarized L-Band Backscattering

    Directory of Open Access Journals (Sweden)

    Nicolas Baghdadi

    2015-10-01

    Full Text Available The objective of this paper is to extend the semi-empirical calibration of the backscattering Integral Equation Model (IEM initially proposed for Synthetic Aperture Radar (SAR data at C- and X-bands to SAR data at L-band. A large dataset of radar signal and in situ measurements (soil moisture and surface roughness over bare soil surfaces were used. This dataset was collected over numerous agricultural study sites in France, Luxembourg, Belgium, Germany and Italy using various SAR sensors (AIRSAR, SIR-C, JERS-1, PALSAR-1, ESAR. Results showed slightly better simulations with exponential autocorrelation function than with Gaussian function and with HH than with VV. Using the exponential autocorrelation function, the mean difference between experimental data and Integral Equation Model (IEM simulations is +0.4 dB in HH and −1.2 dB in VV with a Root Mean Square Error (RMSE about 3.5 dB. In order to improve the modeling results of the IEM for a better use in the inversion of SAR data, a semi-empirical calibration of the IEM was performed at L-band in replacing the correlation length derived from field experiments by a fitting parameter. Better agreement was observed between the backscattering coefficient provided by the SAR and that simulated by the calibrated version of the IEM (RMSE about 2.2 dB.

  1. The demand for gasoline in South Africa. An empirical analysis using co-integration techniques

    International Nuclear Information System (INIS)

    Akinboade, Oludele A.; Ziramba, Emmanuel; Kumo, Wolassa L.

    2008-01-01

    Using the recently developed Autoregressive Distributed Lag (ARDL) bound testing approach to co-integration, suggested by Pesaran et al. (Pesaran, M.H., Shin, Y., Smith, R.J. Bounds Testing Approaches to the Analysis of Level Relationships. Journal of Applied Econometrics 2001; 16(3) 289-326), we empirically analyzed the long-run relationship among the variables in the aggregate gasoline demand function over the period 1978-2005. Our study confirms the existence of a co-integrating relationship. The estimated price and income elasticities of - 0.47 and 0.36 imply that gasoline demand in South Africa is price and income inelastic. (author)

  2. The demand for gasoline in South Africa. An empirical analysis using co-integration techniques

    Energy Technology Data Exchange (ETDEWEB)

    Akinboade, Oludele A.; Ziramba, Emmanuel; Kumo, Wolassa L. [Department of Economics, University of South Africa, P.O.Box 392, Pretoria 0003 (South Africa)

    2008-11-15

    Using the recently developed Autoregressive Distributed Lag (ARDL) bound testing approach to co-integration, suggested by Pesaran et al. (Pesaran, M.H., Shin, Y., Smith, R.J. Bounds Testing Approaches to the Analysis of Level Relationships. Journal of Applied Econometrics 2001; 16(3) 289-326), we empirically analyzed the long-run relationship among the variables in the aggregate gasoline demand function over the period 1978-2005. Our study confirms the existence of a co-integrating relationship. The estimated price and income elasticities of - 0.47 and 0.36 imply that gasoline demand in South Africa is price and income inelastic. (author)

  3. Derivative Market: An Integral Part Of The Zimbabwe Stock Exchange

    OpenAIRE

    Kosmas Njanike

    2010-01-01

    The study assesses the need for a derivative market as an integral of Zimbabwe Stock Exchange. It also aims to evaluate the feasibility of establishing a derivative market as an essential element of Zimbabwe Stock Exchange. The research identifies factors that need to be addressed to facilitate such a market. Views of various fund managers, financial analysts and dealers drawn from asset management firms were used. Changes in market trends are influenced by hyper inflation and acute financial...

  4. An alternative derivation of the Faddeev-Popov path integral

    International Nuclear Information System (INIS)

    Cabo, A.; Martinez, D.L.; Chaichian, M.; Presnajder, P.

    1991-01-01

    A new derivation of the Faddeev-Popov path integral is presented. The use of gauge invariant transformations and gauge fixing conditions in the phase space allows to introduce straightforwardly Lorentz invariant gauge conditions into the path integral, thus avoiding the necessity of going first through a Coulomb-like gauge as it is usually done. The case of systems with finite degrees of freedom and the abelian (QED) one are also presented for illustration. (orig.)

  5. Vertical Integration of Hospitals and Physicians: Economic Theory and Empirical Evidence on Spending and Quality.

    Science.gov (United States)

    Post, Brady; Buchmueller, Tom; Ryan, Andrew M

    2017-08-01

    Hospital-physician vertical integration is on the rise. While increased efficiencies may be possible, emerging research raises concerns about anticompetitive behavior, spending increases, and uncertain effects on quality. In this review, we bring together several of the key theories of vertical integration that exist in the neoclassical and institutional economics literatures and apply these theories to the hospital-physician relationship. We also conduct a literature review of the effects of vertical integration on prices, spending, and quality in the growing body of evidence ( n = 15) to evaluate which of these frameworks have the strongest empirical support. We find some support for vertical foreclosure as a framework for explaining the observed results. We suggest a conceptual model and identify directions for future research. Based on our analysis, we conclude that vertical integration poses a threat to the affordability of health services and merits special attention from policymakers and antitrust authorities.

  6. Diet index-based and empirically derived dietary patterns are associated with colorectal cancer risk.

    Science.gov (United States)

    Miller, Paige E; Lazarus, Philip; Lesko, Samuel M; Muscat, Joshua E; Harper, Gregory; Cross, Amanda J; Sinha, Rashmi; Ryczak, Karen; Escobar, Gladys; Mauger, David T; Hartman, Terryl J

    2010-07-01

    Previous studies have derived patterns by measuring compliance with preestablished dietary guidance or empirical methods, such as principal components analysis (PCA). Our objective was to examine colorectal cancer risk associated with patterns identified by both methods. The study included 431 incident colorectal cancer cases (225 men, 206 women) and 726 healthy controls (330 men, 396 women) participating in a population-based, case-control study. PCA identified sex-specific dietary patterns and the Healthy Eating Index-2005 (HEI-05) assessed adherence to the 2005 Dietary Guidelines for Americans. A fruits and vegetables pattern and a meat, potatoes, and refined grains pattern were identified among men and women; a third pattern (alcohol and sweetened beverages) was identified in men. The fruits and vegetables pattern was inversely associated with risk among men [odds ratio (OR) = 0.38, 95% CI = 0.21-0.69 for the highest compared with the lowest quartile] and women (OR = 0.35, 95% CI = 0.19-0.65). The meat, potatoes, and refined grains pattern was positively associated with risk in women (OR = 2.20, 95% CI = 1.08-4.50) and there was a suggestion of a positive association among men (OR = 1.56, 95% CI = 0.84-2.90; P-trend = 0.070). Men and women with greater HEI-05 scores had a significantly reduced risk of colorectal cancer (OR = 0.56, 95% CI = 0.31-0.99; OR = 0.44, 95% CI = 0.24-0.77, respectively). Following the Dietary Guidelines or a dietary pattern lower in meat, potatoes, high fat, and refined foods and higher in fruits and vegetables may reduce colorectal cancer risk.

  7. Empirical Derivation of Correction Factors for Human Spiral Ganglion Cell Nucleus and Nucleolus Count Units.

    Science.gov (United States)

    Robert, Mark E; Linthicum, Fred H

    2016-01-01

    Profile count method for estimating cell number in sectioned tissue applies a correction factor for double count (resulting from transection during sectioning) of count units selected to represent the cell. For human spiral ganglion cell counts, we attempted to address apparent confusion between published correction factors for nucleus and nucleolus count units that are identical despite the role of count unit diameter in a commonly used correction factor formula. We examined a portion of human cochlea to empirically derive correction factors for the 2 count units, using 3-dimensional reconstruction software to identify double counts. The Neurotology and House Histological Temporal Bone Laboratory at University of California at Los Angeles. Using a fully sectioned and stained human temporal bone, we identified and generated digital images of sections of the modiolar region of the lower first turn of cochlea, identified count units with a light microscope, labeled them on corresponding digital sections, and used 3-dimensional reconstruction software to identify double-counted count units. For 25 consecutive sections, we determined that double-count correction factors for nucleus count unit (0.91) and nucleolus count unit (0.92) matched the published factors. We discovered that nuclei and, therefore, spiral ganglion cells were undercounted by 6.3% when using nucleolus count units. We determined that correction factors for count units must include an element for undercounting spiral ganglion cells as well as the double-count element. We recommend a correction factor of 0.91 for the nucleus count unit and 0.98 for the nucleolus count unit when using 20-µm sections. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.

  8. Using Whole-House Field Tests to Empirically Derive Moisture Buffering Model Inputs

    Energy Technology Data Exchange (ETDEWEB)

    Woods, J.; Winkler, J.; Christensen, D.; Hancock, E.

    2014-08-01

    Building energy simulations can be used to predict a building's interior conditions, along with the energy use associated with keeping these conditions comfortable. These models simulate the loads on the building (e.g., internal gains, envelope heat transfer), determine the operation of the space conditioning equipment, and then calculate the building's temperature and humidity throughout the year. The indoor temperature and humidity are affected not only by the loads and the space conditioning equipment, but also by the capacitance of the building materials, which buffer changes in temperature and humidity. This research developed an empirical method to extract whole-house model inputs for use with a more accurate moisture capacitance model (the effective moisture penetration depth model). The experimental approach was to subject the materials in the house to a square-wave relative humidity profile, measure all of the moisture transfer terms (e.g., infiltration, air conditioner condensate) and calculate the only unmeasured term: the moisture absorption into the materials. After validating the method with laboratory measurements, we performed the tests in a field house. A least-squares fit of an analytical solution to the measured moisture absorption curves was used to determine the three independent model parameters representing the moisture buffering potential of this house and its furnishings. Follow on tests with realistic latent and sensible loads showed good agreement with the derived parameters, especially compared to the commonly-used effective capacitance approach. These results show that the EMPD model, once the inputs are known, is an accurate moisture buffering model.

  9. A Parametric Empirical Bayesian framework for the EEG/MEG inverse problem: generative models for multisubject and multimodal integration

    Directory of Open Access Journals (Sweden)

    Richard N Henson

    2011-08-01

    Full Text Available We review recent methodological developments within a Parametric Empirical Bayesian (PEB framework for reconstructing intracranial sources of extracranial electroencephalographic (EEG and magnetoencephalographic (MEG data under linear Gaussian assumptions. The PEB framework offers a natural way to integrate multiple constraints (spatial priors on this inverse problem, such as those derived from different modalities (e.g., from functional magnetic resonance imaging, fMRI or from multiple replications (e.g., subjects. Using variations of the same basic generative model, we illustrate the application of PEB to three cases: 1 symmetric integration (fusion of MEG and EEG; 2 asymmetric integration of MEG or EEG with fMRI, and 3 group-optimisation of spatial priors across subjects. We evaluate these applications on multimodal data acquired from 18 subjects, focusing on energy induced by face perception within a time-frequency window of 100-220ms, 8-18Hz. We show the benefits of multi-modal, multi-subject integration in terms of the model evidence and the reproducibility (over subjects of cortical responses to faces.

  10. The need of data harmonization to derive robust empirical relationships between soil conditions and vegetation.

    NARCIS (Netherlands)

    Bartholomeus, R.P.; Witte, J.P.M.; van Bodegom, P.M.; Aerts, R.

    2008-01-01

    Question: Is it possible to improve the general applicability and significance of empirical relationships between abiotic conditions and vegetation by harmonization of temporal data? Location: The Netherlands. Methods: Three datasets of vegetation, recorded after periods with different

  11. Estimating the effects of 17α-ethinylestradiol on stochastic population growth rate of fathead minnows: a population synthesis of empirically derived vital rates

    Science.gov (United States)

    Schwindt, Adam R.; Winkelman, Dana L.

    2016-01-01

    Urban freshwater streams in arid climates are wastewater effluent dominated ecosystems particularly impacted by bioactive chemicals including steroid estrogens that disrupt vertebrate reproduction. However, more understanding of the population and ecological consequences of exposure to wastewater effluent is needed. We used empirically derived vital rate estimates from a mesocosm study to develop a stochastic stage-structured population model and evaluated the effect of 17α-ethinylestradiol (EE2), the estrogen in human contraceptive pills, on fathead minnow Pimephales promelas stochastic population growth rate. Tested EE2 concentrations ranged from 3.2 to 10.9 ng L−1 and produced stochastic population growth rates (λ S ) below 1 at the lowest concentration, indicating potential for population decline. Declines in λ S compared to controls were evident in treatments that were lethal to adult males despite statistically insignificant effects on egg production and juvenile recruitment. In fact, results indicated that λ S was most sensitive to the survival of juveniles and female egg production. More broadly, our results document that population model results may differ even when empirically derived estimates of vital rates are similar among experimental treatments, and demonstrate how population models integrate and project the effects of stressors throughout the life cycle. Thus, stochastic population models can more effectively evaluate the ecological consequences of experimentally derived vital rates.

  12. Innovation, Integration and Product Proliferation - Empirical Evidence for the Agri-Food Industry

    OpenAIRE

    Karantininis, Kostas; Sauer, Johannes; Furtan, William Hartley

    2008-01-01

    While mergers, both horizontal and vertical, have been shaping the landscape of the agri-food industry in Europe, the implications of the changing market structure on the level of innovation has not been studied yet. In this paper we deal with the link between innovation and market structure using the empirical example of the Danish agri-food industry. The purpose of this paper is two-fold. First we test for the importance of vertical integration on innovation. While there exist several studi...

  13. Creating a memory of causal relationships an integration of empirical and explanation-based learning methods

    CERN Document Server

    Pazzani, Michael J

    2014-01-01

    This book presents a theory of learning new causal relationships by making use of perceived regularities in the environment, general knowledge of causality, and existing causal knowledge. Integrating ideas from the psychology of causation and machine learning, the author introduces a new learning procedure called theory-driven learning that uses abstract knowledge of causality to guide the induction process. Known as OCCAM, the system uses theory-driven learning when new experiences conform to common patterns of causal relationships, empirical learning to learn from novel experiences, and expl

  14. Deriving all p-brane superalgebras via integrability

    Science.gov (United States)

    Grasso, D. T.; McArthur, I. N.

    2018-03-01

    In previous work we demonstrated that the enlarged super-Poincare algebras which underlie p-brane and D-brane actions in superstring theory can be directly determined based on the integrability of supersymmetry transformations assigned to fields appearing in Wess-Zumino terms. In that work we derived p-brane superalgebras for p = 2 and 3. Here we extend our previous results and give a compact expression for superalgebras for all valid p.

  15. Libor and Swap Market Models for the Pricing of Interest Rate Derivatives : An Empirical Analysis

    NARCIS (Netherlands)

    de Jong, F.C.J.M.; Driessen, J.J.A.G.; Pelsser, A.

    2000-01-01

    In this paper we empirically analyze and compare the Libor and Swap Market Models, developed by Brace, Gatarek, and Musiela (1997) and Jamshidian (1997), using paneldata on prices of US caplets and swaptions.A Libor Market Model can directly be calibrated to observed prices of caplets, whereas a

  16. Empirical studies on the pricing of bonds and interest rate derivatives

    NARCIS (Netherlands)

    Driessen, J.J.A.G.

    2001-01-01

    Nowadays, both large financial and non-financial institutions use models for the term structure of interest rates for risk management and pricing purposes. This thesis focuses on these two important applications of term structure models. In the first part, the empirical performance of several term

  17. Integrable discretization s of derivative nonlinear Schroedinger equations

    International Nuclear Information System (INIS)

    Tsuchida, Takayuki

    2002-01-01

    We propose integrable discretizations of derivative nonlinear Schroedinger (DNLS) equations such as the Kaup-Newell equation, the Chen-Lee-Liu equation and the Gerdjikov-Ivanov equation by constructing Lax pairs. The discrete DNLS systems admit the reduction of complex conjugation between two dependent variables and possess bi-Hamiltonian structure. Through transformations of variables and reductions, we obtain novel integrable discretizations of the nonlinear Schroedinger (NLS), modified KdV (mKdV), mixed NLS, matrix NLS, matrix KdV, matrix mKdV, coupled NLS, coupled Hirota, coupled Sasa-Satsuma and Burgers equations. We also discuss integrable discretizations of the sine-Gordon equation, the massive Thirring model and their generalizations. (author)

  18. Derivation of integral energy balance for the manotea facility

    Energy Technology Data Exchange (ETDEWEB)

    Pollman, Anthony, E-mail: pollman@nps.edu [Mechanical and Aeronautical Engineering Department, United States Naval Postgraduate School, Monterey, CA 93943 (United States); Marzo, Marino di [Fire Protection Engineering Department, University of Maryland, College Park, MD 20742 (United States)

    2013-12-15

    Highlights: • An integral energy balance was derived for the MANOTEA facility. • A second equation was derived which frames transients in terms of inventory alone. • Both equations were implemented and showed good agreement with experimental data. • The equations capture the physical mechanisms behind MANOTEA transients. • Physical understanding is required in order to properly model these transients with TRACE. - Abstract: Rapid-condensation-induced fluid motion occurs in several nuclear reactor accident sequences, as well as during normal operation. Modeling these events is central to our ability to regulate and ensure safe reactor operations. The UMD-USNA Near One-dimensional Transient Experimental Apparatus (MANOTEA) was constructed in order to create a rapid-condensation dataset for subsequent comparison to TRACE output. This paper outlines a derivation of the energy balance for the facility. A path integral based on mass and energy, rather than fluid mechanical, considerations is derived in order to characterize the physical mechanisms governing MANOTEA transients. This equation is further simplified to obtain an expression that frames transients in term of liquid inventory alone. Using data obtained from an actual transient, the path integral is implemented using three variables (change in liquid inventory, liquid inventory as a function of time, and change in metal temperature) to predict the outcome of a fourth independently measured variable (condenser pressure as a function of time). The implementation yields a very good approximation of the actual data. The inventory equation is also implemented and shows reasonable agreement. These equations, and the physical intuition that they yield, are key to properly characterizing MANOTEA transients and any subsequent modeling efforts.

  19. An empirical investigation of the efficiency effects of integrated care models in Switzerland

    Directory of Open Access Journals (Sweden)

    Oliver Reich

    2012-01-01

    Full Text Available Introduction: This study investigates the efficiency gains of integrated care models in Switzerland, since these models are regarded as cost containment options in national social health insurance. These plans generate much lower average health care expenditure than the basic insurance plan. The question is, however, to what extent these total savings are due to the effects of selection and efficiency. Methods: The empirical analysis is based on data from 399,274 Swiss residents that constantly had compulsory health insurance with the Helsana Group, the largest health insurer in Switzerland, covering the years 2006 to 2009. In order to evaluate the efficiency of the different integrated care models, we apply an econometric approach with a mixed-effects model. Results: Our estimations indicate that the efficiency effects of integrated care models on health care expenditure are significant. However, the different insurance plans vary, revealing the following efficiency gains per model: contracted capitated model 21.2%, contracted non-capitated model 15.5% and telemedicine model 3.7%. The remaining 8.5%, 5.6% and 22.5% respectively of the variation in total health care expenditure can be attributed to the effects of selection. Conclusions: Integrated care models have the potential to improve care for patients with chronic diseases and concurrently have a positive impact on health care expenditure. We suggest policy makers improve the incentives for patients with chronic diseases within the existing regulations providing further potential for cost-efficiency of medical care.

  20. An empirical investigation of the efficiency effects of integrated care models in Switzerland

    Directory of Open Access Journals (Sweden)

    Oliver Reich

    2012-01-01

    Full Text Available Introduction: This study investigates the efficiency gains of integrated care models in Switzerland, since these models are regarded as cost containment options in national social health insurance. These plans generate much lower average health care expenditure than the basic insurance plan. The question is, however, to what extent these total savings are due to the effects of selection and efficiency.Methods: The empirical analysis is based on data from 399,274 Swiss residents that constantly had compulsory health insurance with the Helsana Group, the largest health insurer in Switzerland, covering the years 2006 to 2009. In order to evaluate the efficiency of the different integrated care models, we apply an econometric approach with a mixed-effects model.Results: Our estimations indicate that the efficiency effects of integrated care models on health care expenditure are significant. However, the different insurance plans vary, revealing the following efficiency gains per model: contracted capitated model 21.2%, contracted non-capitated model 15.5% and telemedicine model 3.7%. The remaining 8.5%, 5.6% and 22.5% respectively of the variation in total health care expenditure can be attributed to the effects of selection.Conclusions: Integrated care models have the potential to improve care for patients with chronic diseases and concurrently have a positive impact on health care expenditure. We suggest policy makers improve the incentives for patients with chronic diseases within the existing regulations providing further potential for cost-efficiency of medical care.

  1. Derivation of an empirical formula for determining water content of mixed uranyl nitrate-thorium nitrate solutions

    International Nuclear Information System (INIS)

    Min, Duck Kee; Choi, Byung Il; Ro, Seung Gy; Eom, Tae Yoon; Kim, Zong Goo

    1986-01-01

    Densities of a large number of mixed uranyl nitrate-thorium nitrate solutions were measured with pycnometer. By the least squares analysis of the experimental result, an empirical formula for determining water content of mixed uranyl nitrate-thorium nitrate solutions as functions of uranium concentration, thorium concentration and nitric acid normality is derived; W=1.0-0.3580 C u -0.4538 C Th -0.0307H + where W, C u , C Th , and H + stand for water content(g/cc), uranium concentration (g/cc), thorium concentration(g/cc), and nitric acid normality, respectively. Water contents of the mixed uranyl nitrate-thorium nitrate solutions are calculated by using the empirical formular, and compared with the values calculated by Bouly's equation in which an additional data, solution density, is required. The two results show good agreements within 2.7%. (Author)

  2. Time-varying volatility in Malaysian stock exchange: An empirical study using multiple-volatility-shift fractionally integrated model

    Science.gov (United States)

    Cheong, Chin Wen

    2008-02-01

    This article investigated the influences of structural breaks on the fractionally integrated time-varying volatility model in the Malaysian stock markets which included the Kuala Lumpur composite index and four major sectoral indices. A fractionally integrated time-varying volatility model combined with sudden changes is developed to study the possibility of structural change in the empirical data sets. Our empirical results showed substantial reduction in fractional differencing parameters after the inclusion of structural change during the Asian financial and currency crises. Moreover, the fractionally integrated model with sudden change in volatility performed better in the estimation and specification evaluations.

  3. Integrating social science into empirical models of coupled human and natural systems

    Directory of Open Access Journals (Sweden)

    Jeffrey D. Kline

    2017-09-01

    Full Text Available Coupled human and natural systems (CHANS research highlights reciprocal interactions (or feedbacks between biophysical and socioeconomic variables to explain system dynamics and resilience. Empirical models often are used to test hypotheses and apply theory that represent human behavior. Parameterizing reciprocal interactions presents two challenges for social scientists: (1 how to represent human behavior as influenced by biophysical factors and integrate this into CHANS empirical models; (2 how to organize and function as a multidisciplinary social science team to accomplish that task. We reflect on these challenges regarding our CHANS research that investigated human adaptation to fire-prone landscapes. Our project sought to characterize the forest management activities of land managers and landowners (or "actors" and their influence on wildfire behavior and landscape outcomes by focusing on biophysical and socioeconomic feedbacks in central Oregon (USA. We used an agent-based model (ABM to compile biophysical and social information pertaining to actor behavior, and to project future landscape conditions under alternative management scenarios. Project social scientists were tasked with identifying actors' forest management activities and biophysical and socioeconomic factors that influence them, and with developing decision rules for incorporation into the ABM to represent actor behavior. We (1 briefly summarize what we learned about actor behavior on this fire-prone landscape and how we represented it in an ABM, and (2 more significantly, report our observations about how we organized and functioned as a diverse team of social scientists to fulfill these CHANS research tasks. We highlight several challenges we experienced, involving quantitative versus qualitative data and methods, distilling complex behavior into empirical models, varying sensitivity of biophysical models to social factors, synchronization of research tasks, and the need to

  4. RISK MANAGEMENT WITH FINANCIAL DERIVATIVES: EMPIRICAL EVIDENCE FROM ROMANIAN NON-FINANCIAL FIRMS

    Directory of Open Access Journals (Sweden)

    Sorin Gabriel Anton

    2016-12-01

    Full Text Available Financial risk management has rapidly evolved over the past two decades and has become an indispensable function in many institutions from different area of activities. In the last two decades, as the financial markets have become more and more mature, an increasing number of firms from emerging economies have chosen to use derivatives to hedge financial risks. As a result, risk management with financial derivatives has attracted much attention recently, becoming an important topic in the financial literature. However, we know little about the use of financial derivatives by firms from emerging economies and about the effect of these instruments on firms’ risk and value. The aim of the paper is to provide new insights into the use of financial derivatives for hedging purpose by non-financial firms from emerging markets. We analyzed risk management practices on a sample of 68 non-financial firms listed at Bucharest Stock Exchange (BSE over a long time frame (2001 to 2011. We found that Romanian non-financial firms from our sample are exposed mainly to commodity price risk, currency risk, interest rate risk, and liquidity risk. More than half of the firms in our sample (55.88% publish in their annual reports the goal of risk management process. Our results show that 10.29% of non-financial firms in our sample use financial derivatives to hedge their currency, interest rate or commodity price risks. We also found that the volatility caused by the global financial crisis determined many firms to use financial derivatives over the period 2007-2011. Nevertheless, the use of financial derivatives by Romanian non-financial firms is low relative to values registered for other emerging economies. The most important factors that hindered the use of financial derivatives have been the low liquidity of exchange derivatives markets, high hedging costs, and the lack of risk management expertise. The traditional approach of managing risks individually is

  5. Merged/integrated Bathymetric Data Derived from Multibeam Sonar, LiDAR, and Satellite-derived Bathymetry

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Gridded multibeam bathymetry is integrated with derived bathymetry from alternate sources to provide a GIS layer with expanded spatial coverage. Integrated products...

  6. Individual Breast Cancer risk assessment in Underserved Populations: Integrating empirical Bioethics and Health Disparities Research

    Science.gov (United States)

    Anderson, Emily E.; Hoskins, Kent

    2013-01-01

    Research suggests that individual breast cancer risk assessment may improve adherence to recommended screening and prevention guidelines, thereby decreasing morbidity and mortality. Further research on the use of risk assessment models in underserved minority populations is critical to informing national public health efforts to eliminate breast cancer disparities. However, implementing individual breast cancer risk assessment in underserved patient populations raises particular ethical issues that require further examination. After reviewing these issues, we will discuss how empirical bioethics research can be integrated with health disparities research to inform the translation of research findings. Our in-progress National Cancer Institute (NCI) funded study, How Do Underserved Minority Women Think About Breast Cancer?, conducted in the context of a larger study on individual breast cancer risk assessment, is presented as a model. PMID:23124498

  7. The performance of selected semi-empirical and DFT methods in studying C₆₀ fullerene derivatives.

    Science.gov (United States)

    Sikorska, Celina; Puzyn, Tomasz

    2015-11-13

    The capability of reproducing the open circuit voltages (V(oc)) of 15 representative C60 fullerene derivatives was tested using the selected quantum mechanical methods (B3LYP, PM6, and PM7) together with the two one-electron basis sets. Certain theoretical treatments (e.g. PM6) were found to be satisfactory for preliminary estimates of the open circuit voltages (V(oc)), whereas the use of the B3LYP/6-31G(d) approach has been proven to assure highly accurate results. We also examined the structural similarity of 19 fullerene derivatives by employing principle component analysis (PCA). In order to express the structural features of the studied compounds we used molecular descriptors calculated with semi-empirical (PM6 and PM7) and density functional (B3LYP/6-31G(d)) methods separately. In performing PCA, we noticed that semi-empirical methods (i.e. PM6 and PM7) seem satisfactory for molecules, in which one can distinguish the aromatic and the aliphatic parts in the cyclopropane ring of PCBM (phenyl-C61-buteric acid methyl ester) and they significantly overestimate the energy of the highest occupied molecular orbital (E(HOMO)). The use of the B3LYP functional, however, is recommended for studying methanofullerenes, which closely resemble the structure of PCBM, and for their modifications.

  8. An Empirical Derivation of the Run Time of the Bubble Sort Algorithm.

    Science.gov (United States)

    Gonzales, Michael G.

    1984-01-01

    Suggests a moving pictorial tool to help teach principles in the bubble sort algorithm. Develops such a tool applied to an unsorted list of numbers and describes a method to derive the run time of the algorithm. The method can be modified to run the times of various other algorithms. (JN)

  9. Integrated ensemble noise-reconstructed empirical mode decomposition for mechanical fault detection

    Science.gov (United States)

    Yuan, Jing; Ji, Feng; Gao, Yuan; Zhu, Jun; Wei, Chenjun; Zhou, Yu

    2018-05-01

    A new branch of fault detection is utilizing the noise such as enhancing, adding or estimating the noise so as to improve the signal-to-noise ratio (SNR) and extract the fault signatures. Hereinto, ensemble noise-reconstructed empirical mode decomposition (ENEMD) is a novel noise utilization method to ameliorate the mode mixing and denoised the intrinsic mode functions (IMFs). Despite the possibility of superior performance in detecting weak and multiple faults, the method still suffers from the major problems of the user-defined parameter and the powerless capability for a high SNR case. Hence, integrated ensemble noise-reconstructed empirical mode decomposition is proposed to overcome the drawbacks, improved by two noise estimation techniques for different SNRs as well as the noise estimation strategy. Independent from the artificial setup, the noise estimation by the minimax thresholding is improved for a low SNR case, which especially shows an outstanding interpretation for signature enhancement. For approximating the weak noise precisely, the noise estimation by the local reconfiguration using singular value decomposition (SVD) is proposed for a high SNR case, which is particularly powerful for reducing the mode mixing. Thereinto, the sliding window for projecting the phase space is optimally designed by the correlation minimization. Meanwhile, the reasonable singular order for the local reconfiguration to estimate the noise is determined by the inflection point of the increment trend of normalized singular entropy. Furthermore, the noise estimation strategy, i.e. the selection approaches of the two estimation techniques along with the critical case, is developed and discussed for different SNRs by means of the possible noise-only IMF family. The method is validated by the repeatable simulations to demonstrate the synthetical performance and especially confirm the capability of noise estimation. Finally, the method is applied to detect the local wear fault

  10. INTEGRATION OF IMAGE-DERIVED AND POS-DERIVED FEATURES FOR IMAGE BLUR DETECTION

    Directory of Open Access Journals (Sweden)

    T.-A. Teo

    2016-06-01

    Full Text Available The image quality plays an important role for Unmanned Aerial Vehicle (UAV’s applications. The small fixed wings UAV is suffering from the image blur due to the crosswind and the turbulence. Position and Orientation System (POS, which provides the position and orientation information, is installed onto an UAV to enable acquisition of UAV trajectory. It can be used to calculate the positional and angular velocities when the camera shutter is open. This study proposes a POS-assisted method to detect the blur image. The major steps include feature extraction, blur image detection and verification. In feature extraction, this study extracts different features from images and POS. The image-derived features include mean and standard deviation of image gradient. For POS-derived features, we modify the traditional degree-of-linear-blur (blinear method to degree-of-motion-blur (bmotion based on the collinear condition equations and POS parameters. Besides, POS parameters such as positional and angular velocities are also adopted as POS-derived features. In blur detection, this study uses Support Vector Machines (SVM classifier and extracted features (i.e. image information, POS data, blinear and bmotion to separate blur and sharp UAV images. The experiment utilizes SenseFly eBee UAV system. The number of image is 129. In blur image detection, we use the proposed degree-of-motion-blur and other image features to classify the blur image and sharp images. The classification result shows that the overall accuracy using image features is only 56%. The integration of image-derived and POS-derived features have improved the overall accuracy from 56% to 76% in blur detection. Besides, this study indicates that the performance of the proposed degree-of-motion-blur is better than the traditional degree-of-linear-blur.

  11. Empirically Derived Dietary Patterns in UK Adults Are Associated with Sociodemographic Characteristics, Lifestyle, and Diet Quality

    Science.gov (United States)

    Cade, Janet; Dawson, Jeremy; Holdsworth, Michelle

    2018-01-01

    The aim of this study was to examine empirical dietary patterns in UK adults and their association with sociodemographic characteristics, lifestyle factors, self-reported nutrient intake, nutrient biomarkers, and the Nutrient-based Diet Quality Score (NDQS) using National Diet and Nutrition Survey data 2008–2012 (n = 2083; mean age 49 years; 43.3% male). Four patterns explained 13.6% of the total variance: ‘Snacks, fast food, fizzy drinks’ (SFFFD), ‘Fruit, vegetables, oily fish’ (FVOF), ‘Meat, potatoes, beer’ (MPB), and ‘Sugary foods, dairy’ (SFD). ‘SFFFD’ was associated positively with: being male; smoking; body mass index (BMI); urinary sodium; intake of non-milk extrinsic sugars (NMES), fat and starch; and negatively with: age; plasma carotenoids; and NDQS. ‘FVOF’ was associated positively with: being non-white; age; income; socioeconomic classification (National Statistics Socio-economic Classifications; NSSEC); plasma carotenoids; intake of non-starch polysaccharides and polyunsaturated fatty acids. It was negatively associated with: being male, smoking, BMI, urinary sodium, intake of saturated fat; and NMES and NDQS. Whilst the patterns explained only 13.6% of the total variance, they were associated with self-reported nutrient intake, biomarkers of nutrient intake, sociodemographic and lifestyle variables, and the NDQS. These findings provide support for dietary patterns analyses as a means of exploring dietary intake in the UK population to inform public health nutrition policy and guidance. PMID:29415478

  12. New GRACE-Derived Storage Change Estimates Using Empirical Mode Extraction

    Science.gov (United States)

    Aierken, A.; Lee, H.; Yu, H.; Ate, P.; Hossain, F.; Basnayake, S. B.; Jayasinghe, S.; Saah, D. S.; Shum, C. K.

    2017-12-01

    Estimated mass change from GRACE spherical harmonic solutions have north/south stripes and east/west banded errors due to random noise and modeling errors. Low pass filters like decorrelation and Gaussian smoothing are typically applied to reduce noise and errors. However, these filters introduce leakage errors that need to be addressed. GRACE mascon estimates (JPL and CSR mascon solutions) do not need decorrelation or Gaussian smoothing and offer larger signal magnitudes compared to the GRACE spherical harmonics (SH) filtered results. However, a recent study [Chen et al., JGR, 2017] demonstrated that both JPL and CSR mascon solutions also have leakage errors. We developed a new postprocessing method based on empirical mode decomposition to estimate mass change from GRACE SH solutions without decorrelation and Gaussian smoothing, the two main sources of leakage errors. We found that, without any post processing, the noise and errors in spherical harmonic solutions introduced very clear high frequency components in the spatial domain. By removing these high frequency components and reserve the overall pattern of the signal, we obtained better mass estimates with minimum leakage errors. The new global mass change estimates captured all the signals observed by GRACE without the stripe errors. Results were compared with traditional methods over the Tonle Sap Basin in Cambodia, Northwestern India, Central Valley in California, and the Caspian Sea. Our results provide larger signal magnitudes which are in good agreement with the leakage corrected (forward modeled) SH results.

  13. Empirical Derivation and Validation of a Clinical Case Definition for Neuropsychological Impairment in Children and Adolescents.

    Science.gov (United States)

    Beauchamp, Miriam H; Brooks, Brian L; Barrowman, Nick; Aglipay, Mary; Keightley, Michelle; Anderson, Peter; Yeates, Keith O; Osmond, Martin H; Zemek, Roger

    2015-09-01

    Neuropsychological assessment aims to identify individual performance profiles in multiple domains of cognitive functioning; however, substantial variation exists in how deficits are defined and what cutoffs are used, and there is no universally accepted definition of neuropsychological impairment. The aim of this study was to derive and validate a clinical case definition rule to identify neuropsychological impairment in children and adolescents. An existing normative pediatric sample was used to calculate base rates of abnormal functioning on eight measures covering six domains of neuropsychological functioning. The dataset was analyzed by varying the range of cutoff levels [1, 1.5, and 2 standard deviations (SDs) below the mean] and number of indicators of impairment. The derived rule was evaluated by bootstrap, internal and external clinical validation (orthopedic and traumatic brain injury). Our neuropsychological impairment (NPI) rule was defined as "two or more test scores that fall 1.5 SDs below the mean." The rule identifies 5.1% of the total sample as impaired in the assessment battery and consistently targets between 3 and 7% of the population as impaired even when age, domains, and number of tests are varied. The NPI rate increases in groups known to exhibit cognitive deficits. The NPI rule provides a psychometrically derived method for interpreting performance across multiple tests and may be used in children 6-18 years. The rule may be useful to clinicians and scientists who wish to establish whether specific individuals or clinical populations present within expected norms versus impaired function across a battery of neuropsychological tests.

  14. An Empirical Ultraviolet Template for Iron Emission in Quasars as Derived from I Zw 1

    DEFF Research Database (Denmark)

    Vestergaard, Marianne; Wilkes, B. J.

    2001-01-01

    contaminant in optical--UV spectra of AGNs. Its presence complicates and limits the accuracy of measurements of both strong and weak emission lines and the continuum emission, affecting studies of line and continuum interrelations, the ionization structure, and elemental abundances in AGNs. Despite the wealth...... iron spectrum make the template particularly suitable for use with most AGN spectra. The iron emission spectrum and the line identifications and measurements are presented and compared with the work of Laor et al. We illustrate the application of the derived FeII and FeIII templates by fitting...

  15. Integration of least angle regression with empirical Bayes for multi-locus genome-wide association studies

    Science.gov (United States)

    Multi-locus genome-wide association studies has become the state-of-the-art procedure to identify quantitative trait loci (QTL) associated with traits simultaneously. However, implementation of multi-locus model is still difficult. In this study, we integrated least angle regression with empirical B...

  16. First and second derivatives of two electron integrals over Cartesian Gaussians using Rys polynomials

    International Nuclear Information System (INIS)

    Schlegel, H.B.; Binkley, J.S.; Pople, J.A.

    1984-01-01

    Formulas are developed for the first and second derivatives of two electron integrals over Cartesian Gaussians. Integrals and integral derivatives are evaluated by the Rys polynomial method. Higher angular momentum functions are not used to calculate the integral derivatives; instead the integral formulas are differentiated directly to produce compact and efficient expressions for the integral derivatives. The use of this algorithm in the ab initio molecular orbital programs gaussIan 80 and gaussIan 82 is discussed. Representative timings for some small molecules with several basis sets are presented. This method is compared with previously published algorithms and its computational merits are discussed

  17. Integrating real-time subsurface hydrologic monitoring with empirical rainfall thresholds to improve landslide early warning

    Science.gov (United States)

    Mirus, Benjamin B.; Becker, Rachel E.; Baum, Rex L.; Smith, Joel B.

    2018-01-01

    Early warning for rainfall-induced shallow landsliding can help reduce fatalities and economic losses. Although these commonly occurring landslides are typically triggered by subsurface hydrological processes, most early warning criteria rely exclusively on empirical rainfall thresholds and other indirect proxies for subsurface wetness. We explore the utility of explicitly accounting for antecedent wetness by integrating real-time subsurface hydrologic measurements into landslide early warning criteria. Our efforts build on previous progress with rainfall thresholds, monitoring, and numerical modeling along the landslide-prone railway corridor between Everett and Seattle, Washington, USA. We propose a modification to a previously established recent versus antecedent (RA) cumulative rainfall thresholds by replacing the antecedent 15-day rainfall component with an average saturation observed over the same timeframe. We calculate this antecedent saturation with real-time telemetered measurements from five volumetric water content probes installed in the shallow subsurface within a steep vegetated hillslope. Our hybrid rainfall versus saturation (RS) threshold still relies on the same recent 3-day rainfall component as the existing RA thresholds, to facilitate ready integration with quantitative precipitation forecasts. During the 2015–2017 monitoring period, this RS hybrid approach has an increase of true positives and a decrease of false positives and false negatives relative to the previous RA rainfall-only thresholds. We also demonstrate that alternative hybrid threshold formats could be even more accurate, which suggests that further development and testing during future landslide seasons is needed. The positive results confirm that accounting for antecedent wetness conditions with direct subsurface hydrologic measurements can improve thresholds for alert systems and early warning of rainfall-induced shallow landsliding.

  18. An approach to derive some simple empirical equations to calibrate nuclear and acoustic well logging tools.

    Science.gov (United States)

    Mohammad Al Alfy, Ibrahim

    2018-01-01

    A set of three pads was constructed from primary materials (sand, gravel and cement) to calibrate the gamma-gamma density tool. A simple equation was devised to convert the qualitative cps values to quantitative g/cc values. The neutron-neutron porosity tool measures the qualitative cps porosity values. A direct equation was derived to calculate the porosity percentage from the cps porosity values. Cement-bond log illustrates the cement quantities, which surround well pipes. This log needs a difficult process due to the existence of various parameters, such as: drilling well diameter as well as internal diameter, thickness and type of well pipes. An equation was invented to calculate the cement percentage at standard conditions. This equation can be modified according to varying conditions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Internal Control of Derivatives Usage by Spanish Savings Banks: An Empirical Survey

    Directory of Open Access Journals (Sweden)

    Ana Fernández-Laviada

    2007-12-01

    Full Text Available Global derivatives activity continues to expand although they have provided some of the most devastating financial disasters. The debate on their regulation has always been present and is still unresolved. However, without undervaluing the importance of regulation and the usefulness of an adequate external control, a sound internal control system is essential to prevent new financial scandals. First of all, this paper, through the review of existing recommendations, rules, regulation and academic literature, studies and analyses the need and importance of internal control in derivative usage for risk management. And secondly, through a questionnaire about established policies, procedures and internal controls, it provides evidence related to its usage and control by Spanish savings banks.El uso de los derivados sigue en expansión a pesar de haber ocasionado alguno de los mayoresescándalos financieros.El debate sobre su regulación, todavía sin resolver, ha estado siempre presente. No obstante,y sin menospreciar la importancia de la regulación y la utilidad de un adecuado controlexterno, un buen sistema de control interno es esencial para prevenir nuevos desastres.Este trabajo, en primer lugar, a través de la revisión de las recomendaciones, normas,regulación y literatura académica existente, estudia y analiza la necesidad e importancia delcontrol interno en el uso de los derivados para la gestión del riesgo. Y en segundo lugar, através de un cuestionario sobre las políticas, procedimientos y controles internos establecidos,aporta evidencia sobre el uso y control de los mismos por las cajas de ahorros españolas.

  20. Empirically derived dimensional syndromes of self-reported psychopathology: Cross-cultural comparisons of Portuguese and US elders.

    Science.gov (United States)

    Ivanova, Masha Y; Achenbach, Thomas; Leite, Manuela; Almeida, Vera; Caldas, Carlos; Turner, Lori; Dumas, Julie A

    2018-05-01

    As the world population ages, mental health professionals increasingly need empirically supported assessment instruments for older adult psychopathology. This study tested the degree to which syndromes derived from self-ratings of psychopathology by elders in the US would fit self-ratings by elders in Portugal. The Older Adult Self-Report (OASR) was completed by 352 60- to 102-year-olds in Portuguese community and residential settings. Confirmatory factor analyses tested the fit of the 7-syndrome OASR model to self-ratings by Portuguese elders. The primary fit index (Root Mean Square Error of Approximation) showed good fit, while secondary fit indices (the Comparative Fit Index and the Tucker-Lewis Index) showed acceptable fit. Loadings of 95 of the 97 items on their expected syndromes were statistically significant (mean = .63), indicating that the items measured the syndromes well. Correlations between latent factors, ie, between the hypothesized syndrome constructs measured by the items, averaged .66. The correlations between syndromes reflect varying degrees of comorbidity between problems comprising particular pairs of syndromes. The results support the syndrome structure of the OASR for Portuguese elders, offering Portuguese clinicians and researchers a useful instrument for assessing a broad spectrum of psychopathology. The results also offer a core of empirically supported taxonomic constructs of later life psychopathology as a basis for advancing clinical practice, training, and cross-cultural research. Copyright © 2017 John Wiley & Sons, Ltd.

  1. Precision comparison of the erosion rates derived from 137Cs measurements models with predictions based on empirical relationship

    International Nuclear Information System (INIS)

    Yang Mingyi; Liu Puling; Li Liqing

    2004-01-01

    The soil samples were collected in 6 cultivated runoff plots with grid sampling method, and the soil erosion rates derived from 137 Cs measurements were calculated. The models precision of Zhang Xinbao, Zhou Weizhi, Yang Hao and Walling were compared with predictions based on empirical relationship, data showed that the precision of 4 models is high within 50m slope length except for the slope with low slope angle and short length. Relatively, the precision of Walling's model is better than that of Zhang Xinbao, Zhou Weizhi and Yang Hao. In addition, the relationship between parameter Γ in Walling's improved model and slope angle was analyzed, the ralation is: Y=0.0109 X 1.0072 . (authors)

  2. Empirically derived dietary patterns and health-related quality of life in the SUN project.

    Directory of Open Access Journals (Sweden)

    Cristina Ruano

    Full Text Available The analysis of dietary patterns has become a valuable tool to examine diet-disease relationships but little is known about their effects on quality of life. Our aim was to ascertain the association between major dietary patterns and mental and physical quality of life after 4 years of follow-up.This analysis included 11,128 participants from the "Seguimiento Universidad de Navarra" (SUN cohort. Dietary habits were assessed using a validated food-frequency questionnaire. Factor analysis was used to derive dietary patterns. Quality of life was measured with the validated Spanish version of the SF-36 Health Survey.Two major dietary patterns were identified, the 'Western' dietary pattern (rich in red meats, processed pastries and fast-food and the "Mediterranean" dietary pattern (high in fruits, vegetables and olive oil. After controlling for confounders, the Western dietary pattern was associated with quality of life in all domains. The magnitude of these differences between the subjects in the highest (quintile 5 and the lowest quintile of adherence to the Western pattern ranged from -0.8 (for mental health to -3.5 (for vitality. On the contrary, the Mediterranean dietary pattern was associated with better quality of life domains: differences ranged from +1.3 (for physical functioning to +3.4 (for vitality when comparing extreme quintiles of adherence. Additional sensitivity analyses did not change the reported differences.Whereas baseline adherence to a Western dietary pattern was inversely associated with self-perceived quality of life after 4 years of follow-up, baseline adherence to a Mediterranean dietary pattern was directly associated with better scores in quality of life four years later in the SUN Project.

  3. Empirically derived dietary patterns and health-related quality of life in the SUN project.

    Science.gov (United States)

    Ruano, Cristina; Henriquez, Patricia; Martínez-González, Miguel Ángel; Bes-Rastrollo, Maira; Ruiz-Canela, Miguel; Sánchez-Villegas, Almudena

    2013-01-01

    The analysis of dietary patterns has become a valuable tool to examine diet-disease relationships but little is known about their effects on quality of life. Our aim was to ascertain the association between major dietary patterns and mental and physical quality of life after 4 years of follow-up. This analysis included 11,128 participants from the "Seguimiento Universidad de Navarra" (SUN) cohort. Dietary habits were assessed using a validated food-frequency questionnaire. Factor analysis was used to derive dietary patterns. Quality of life was measured with the validated Spanish version of the SF-36 Health Survey. Two major dietary patterns were identified, the 'Western' dietary pattern (rich in red meats, processed pastries and fast-food) and the "Mediterranean" dietary pattern (high in fruits, vegetables and olive oil). After controlling for confounders, the Western dietary pattern was associated with quality of life in all domains. The magnitude of these differences between the subjects in the highest (quintile 5) and the lowest quintile of adherence to the Western pattern ranged from -0.8 (for mental health) to -3.5 (for vitality). On the contrary, the Mediterranean dietary pattern was associated with better quality of life domains: differences ranged from +1.3 (for physical functioning) to +3.4 (for vitality) when comparing extreme quintiles of adherence. Additional sensitivity analyses did not change the reported differences. Whereas baseline adherence to a Western dietary pattern was inversely associated with self-perceived quality of life after 4 years of follow-up, baseline adherence to a Mediterranean dietary pattern was directly associated with better scores in quality of life four years later in the SUN Project.

  4. Teaching Integrity in Empirical Research: A Protocol for Documenting Data Management and Analysis

    Science.gov (United States)

    Ball, Richard; Medeiros, Norm

    2012-01-01

    This article describes a protocol the authors developed for teaching undergraduates to document their statistical analyses for empirical research projects so that their results are completely reproducible and verifiable. The protocol is guided by the principle that the documentation prepared to accompany an empirical research project should be…

  5. Application of semi-empirical modeling and non-linear regression to unfolding fast neutron spectra from integral reaction rate data

    International Nuclear Information System (INIS)

    Harker, Y.D.

    1976-01-01

    A semi-empirical analytical expression representing a fast reactor neutron spectrum has been developed. This expression was used in a non-linear regression computer routine to obtain from measured multiple foil integral reaction data the neutron spectrum inside the Coupled Fast Reactivity Measurement Facility. In this application six parameters in the analytical expression for neutron spectrum were adjusted in the non-linear fitting process to maximize consistency between calculated and measured integral reaction rates for a set of 15 dosimetry detector foils. In two-thirds of the observations the calculated integral agreed with its respective measured value to within the experimental standard deviation, and in all but one case agreement within two standard deviations was obtained. Based on this quality of fit the estimated 70 to 75 percent confidence intervals for the derived spectrum are 10 to 20 percent for the energy range 100 eV to 1 MeV, 10 to 50 percent for 1 MeV to 10 MeV and 50 to 90 percent for 10 MeV to 18 MeV. The analytical model has demonstrated a flexibility to describe salient features of neutron spectra of the fast reactor type. The use of regression analysis with this model has produced a stable method to derive neutron spectra from a limited amount of integral data

  6. Correcting orbital drift signal in the time series of AVHRR derived convective cloud fraction using rotated empirical orthogonal function

    Directory of Open Access Journals (Sweden)

    A. Devasthale

    2012-02-01

    Full Text Available The Advanced Very High Resolution Radiometer (AVHRR instruments onboard the series of National Oceanic and Atmospheric Administration (NOAA satellites offer the longest available meteorological data records from space. These satellites have drifted in orbit resulting in shifts in the local time sampling during the life span of the sensors onboard. Depending upon the amplitude of the diurnal cycle of the geophysical parameters derived, orbital drift may cause spurious trends in their time series. We investigate tropical deep convective clouds, which show pronounced diurnal cycle amplitude, to estimate an upper bound of the impact of orbital drift on their time series. We carry out a rotated empirical orthogonal function analysis (REOF and show that the REOFs are useful in delineating orbital drift signal and, more importantly, in subtracting this signal in the time series of convective cloud amount. These results will help facilitate the derivation of homogenized data series of cloud amount from NOAA satellite sensors and ultimately analyzing trends from them. However, we suggest detailed comparison of various methods and rigorous testing thereof applying final orbital drift corrections.

  7. Integrated management systems and workflow-based electronic document management: An empirical study

    Directory of Open Access Journals (Sweden)

    Hang Thu Pho

    2014-01-01

    Full Text Available Purpose: Many global organizations have aligned their strategy and operation via the ISO-based framework of integrated management system (IMS that allows them to merge quality, environment, health and safety management systems. In such context, having a robust electronic document management system (EDMS is essential, especially at global enterprises where a large amount of documents generated by processes flows through different work cultures. However, there is no "one-size-fits-all" design for EDMS because it depends on organizations' needs, size and resource allocation. This article discusses the interrelation between EDMS and IMS in order to suggest a best practice. Design/methodology/approach: This article methodologically based upon a qualitative, interpretivistic, longitudinal empirical study in a wind turbine factory. Findings and Originality/value: IMS improvement and effectiveness has been overlooking EDMS as a key factor in establishing appropriate technological support of the IMS processes. Rightful application of EDMS can further contribute to organizational learning, precision of documentation and cross-organisational collaboration. Research limitations/implications: Theorising on IMS needs a stronger perspective of the technological limitations and potentials of basing IMS on EDMS. Practical implications: IMS are complex systems involving a large number of administrative functions. EDMS provides a formal representation with automation potentials both heightening and securing document trustworthiness. Social implications: IMS has a tendency to stay with professionals, e.g. line managers and QA/QC/QMS professionals. The EDMS line of discussion suggests a broader inclusion. Originality/value: Researching IMS as a technological implementation is giving a better platform of aligning the IMS with other business processes and is bringing IMS closer to the operational activities within the enterprise.

  8. Integrated tuning of PID-derivative load frequency controller for two ...

    African Journals Online (AJOL)

    Results of the proposed derivative controller have been compared with conventional proportional integral derivative controller in time domain analysis. A remarkable improvement in stability of the system has ... the feasibility of the proposed PID-derivative filter controller. Keywords: controller; derivative filter; tie line; two area ...

  9. Derivation of a semi-empirical formula for the quantum efficiency of forward secondary electron emission from γ-irradiated metals. 2

    International Nuclear Information System (INIS)

    Nakamura, Masamoto; Katoh, Yoh

    1994-01-01

    An empirical formula for the quantum efficiency of electrons irradiated with 60 Co γ-rays was reported in a previous paper, but its physical meaning was not made clear. Then, a simple model was assumed, from which a formula for calculating the efficiency was theoretically derived. Some parameters in the formula were determined so that the calculated results might fit the experimental data. The above empirical formula was shown to be the same as the formula physically derived this time. Results from the semiempirical formula and experimental data for Al and Pb sample were in agreement within the limits of 5%. (author)

  10. Derivative-Based Trapezoid Rule for the Riemann-Stieltjes Integral

    Directory of Open Access Journals (Sweden)

    Weijing Zhao

    2014-01-01

    Full Text Available The derivative-based trapezoid rule for the Riemann-Stieltjes integral is presented which uses 2 derivative values at the endpoints. This kind of quadrature rule obtains an increase of two orders of precision over the trapezoid rule for the Riemann-Stieltjes integral and the error term is investigated. At last, the rationality of the generalization of derivative-based trapezoid rule for Riemann-Stieltjes integral is demonstrated.

  11. Diagnostic Classification of Eating Disorders in Children and Adolescents: How Does DSM-IV-TR Compare to Empirically-Derived Categories?

    Science.gov (United States)

    Eddy, Kamryn T.; Le Grange, Daniel; Crosby, Ross D.; Hoste, Renee Rienecke; Doyle, Angela Celio; Smyth, Angela; Herzog, David B.

    2010-01-01

    Objective: The purpose of this study was to empirically derive eating disorder phenotypes in a clinical sample of children and adolescents using latent profile analysis (LPA), and to compare these latent profile (LP) groups to the DSM-IV-TR eating disorder categories. Method: Eating disorder symptom data collected from 401 youth (aged 7 through 19…

  12. Forest canopy effects on snow accumulation and ablation: an integrative review of empirical results

    Science.gov (United States)

    Andres Varhola; Nicholas C. Coops; Markus Weiler; R. Dan Moore

    2010-01-01

    The past century has seen significant research comparing snow accumulation and ablation in forested and open sites. In this review we compile and standardize the results of previous empirical studies to generate statistical relations between changes in forest cover and the associated changes in snow accumulation and ablation rate. The analysis drew upon 33 articles...

  13. Integrating social science into empirical models of coupled human and natural systems

    Science.gov (United States)

    Jeffrey D. Kline; Eric M. White; A Paige Fischer; Michelle M. Steen-Adams; Susan Charnley; Christine S. Olsen; Thomas A. Spies; John D. Bailey

    2017-01-01

    Coupled human and natural systems (CHANS) research highlights reciprocal interactions (or feedbacks) between biophysical and socioeconomic variables to explain system dynamics and resilience. Empirical models often are used to test hypotheses and apply theory that represent human behavior. Parameterizing reciprocal interactions presents two challenges for social...

  14. The Impact of Organizational Structure on Internal and External Integration: An empirical, cross-regional assessment

    Directory of Open Access Journals (Sweden)

    Xenophon Koufteros

    2014-06-01

    Full Text Available We examine the effects of organizational structure on cross-functional integration, supplier integration, and customer integration and assess whether such effects vary by geographical region. Specifically, we investigate the impact of centralization, formalization, and complexity on both internal (cross-functional and external (supplier, customer integration. Relationships are examined across Western and East Asian environments using data collected from 238 manufacturing plants in eight countries. We find that structural features have differing impacts on cross-functional, supplier, and customer integration, and these effects vary across geographical regions.

  15. Imperial Policy and the Integration of Gaul into the Roman Empire

    Science.gov (United States)

    2015-06-12

    ECONOMIC BENEFITS OF EMPIRE From as early as the second century BC Gaul had a taste for the material outputs of the Roman economy. Wine in particular...Rome tolerated the establishment of local Gallic production. This meant the growth in Gaul’s wine consumption benefited Gallic producers and not...exporter of sought after wines . Wine production was not the only industry that benefited from the Roman conquest. Complementing Gallic viticulture

  16. The Empirical Evidence on Government Bond Market Integration in East Asia

    Directory of Open Access Journals (Sweden)

    Lian Liu

    2016-03-01

    Full Text Available This research intends to investigate the progress made in East Asian bond market integration thus far. Price-based measures (AAD indicator and beta-convergence measure, quantity-based measures and econometric techniques (co-integration test, error correction model based Granger causality test are employed in the analysis. Even though East Asian government bond markets have become more integrated since 2001, the differentials among the markets still remain significantly high. The bond market integration process seems slow. The convergence of bond markets sped up in 2003 and after the 2008 world financial crisis, implying the important role of government policies in integrating the regional bond markets. East Asian bond market integration may need more government-directed measures.

  17. ARE METHODS USED TO INTEGRATE STANDARDIZED MANAGEMENT SYSTEMS A CONDITIONING FACTOR OF THE LEVEL OF INTEGRATION? AN EMPIRICAL STUDY

    Directory of Open Access Journals (Sweden)

    Merce Bernardo

    2011-09-01

    Full Text Available Organizations are increasingly implementing multiple Management System Standards (M SSs and considering managing the related Management Systems (MSs as a single system.The aim of this paper is to analyze if methods us ed to integrate standardized MSs condition the level of integration of those MSs. A descriptive methodology has been applied to 343 Spanish organizations registered to, at least, ISO 9001 and ISO 14001. Seven groups of these organizations using different combinations of methods have been analyzed Results show that these organizations have a high level of integration of their MSs. The most common method used, was the process map. Organizations using a combination of different methods achieve higher levels of integration than those using a single method. However, no evidence has been found to confirm the relationship between the method used and the integration level achieved.

  18. Integrity violations and corruption in Western public governance: Empirical evidence and reflection from the Netherlands

    NARCIS (Netherlands)

    de Graaf, Gjalt; Huberts, L.W.J.C.; Strüwer, T.

    2018-01-01

    How often integrity violations occur in Western governance, and the precise nature of these violations, is as yet not very clear. Data on this subject—drawn from experience in the Netherlands—are presented here. The main research question is: What is the scale of integrity violations within Dutch

  19. Farm Household Economic Model of The Integrated Crop Livestock System: Conceptual and Empirical Study

    Directory of Open Access Journals (Sweden)

    Atien Priyanti

    2007-06-01

    Full Text Available An integrated approach to enhance rice production in Indonesia is very prospectus throughout the implementation of adapted and liable integrated program. One of the challenges in rice crop sub sector is the stagnation of its production due to the limitation of organic matter availability. This provides an opportunity for livestock development to overcome the problems on land fertility through the use of manure as the source of organic fertilizer. Ministry of Agriculture had implemented a program on Increasing Integrated Rice Productivity with an Integrated Crop Livestock System as one of the potential components since 2002. Integrated crop livestock system program with special reference to rice field and beef cattle is an alternative to enhance the potential development of agriculture sector in Indonesia. The implementation on this integrated program is to enhance rice production and productivity through a system involving beef cattle with its goal on increasing farmers’ income. Household economic model can be used as one of the analysis to evaluate the success of the implemented crop livestock system program. The specificity of the farmers is that rationality behavior of the role as production and consumption decision making. In this case, farmers perform the production to meet home consumption based on the resources that used directly for its production. The economic analysis of farmers household can be described to anticipate policy options through this model. Factors influencing farmers’ decisions and direct interrelations to production and consumption aspects that have complex implications for the farmers’ welfare of the integrated crop livestock system program.

  20. An IoT-enabled supply chain integration framework : empirical case studies

    OpenAIRE

    Wakenshaw, Susan Y. L.; Maple, Carsten; Chen, Daqiang; Micillo, Rosario

    2017-01-01

    Supply chain integration is crucial for supply chain performance, particularly in industry 4.0. With the proliferation of Internet of Things (IoT) and the use of cyber-physical systems, supply chain integration needs to be greatly enhanced. In this paper, we explore supply integration (process and application) in the supply chain network enabled by IoT. Using the case study method, we investigate technical and business applications of IoT in supply chains and how it can interface with the pro...

  1. Narcissistic personality disorder: an integrative review of recent empirical data and current definitions.

    Science.gov (United States)

    Roepke, Stefan; Vater, Aline

    2014-05-01

    Although concepts of pathological narcissism are as old as psychology and psychiatry itself, only a small number of clinical studies are based on the criteria for narcissistic personality disorder (NPD), as defined in the Diagnostic and Statistical Manuals of Mental Disorders (DSM). As a result, NPD appears to be one of the most controversially discussed nosological entities in psychiatry. Whereas the majority of empirical studies used self or other ratings of NPD criteria to address issues of reliability and validity of the diagnostic category (i.e., internal consistency, factor structure, discriminant validity), only recent research has applied experimental designs to investigate specific features of NPD (e.g., self-esteem, empathy, shame). The aim of this review is to summarize available empirical data on NPD and relate these findings to current definitions of NPD (according to the DSM-5, [1]). In order to do so, this review follows the five steps to establishing diagnostic validity proposed by Robins and Guze [2], i.e., (1) clinical description, (2) laboratory studies, (3) delimitation from other disorders, (4) family studies, and (5) follow up studies. Finally, this review suggests pathways for future research that may assist further nosological evaluation of NPD and contribute to the overall goal, the improvement of treatment for patients.

  2. A review and integration of empirical evidence on internal economy in marketing channel relationships

    DEFF Research Database (Denmark)

    Jensen, Nils Bøgelund; Skytte, Hans

    Papiret gennemgår empirisk forskning omkring intern økonomi i distributionskanaler. Ved intern økonomi forstås graden af vertikal integration og beslutningsprocesser i distributionskanaler. På basis af gennemgangen diskuteres konklusioner og resultaterne integreres....

  3. Empirically Derived Dehydration Scoring and Decision Tree Models for Children With Diarrhea: Assessment and Internal Validation in a Prospective Cohort Study in Dhaka, Bangladesh

    OpenAIRE

    Levine, Adam C; Glavis-Bloom, Justin; Modi, Payal; Nasrin, Sabiha; Rege, Soham; Chu, Chieh; Schmid, Christopher H; Alam, Nur H

    2015-01-01

    Introduction: Diarrhea remains one of the most common and most deadly conditions affecting children worldwide. Accurately assessing dehydration status is critical to determining treatment course, yet no clinical diagnostic models for dehydration have been empirically derived and validated for use in resource-limited settings. Methods: In the Dehydration: Assessing Kids Accurately (DHAKA) prospective cohort study, a random sample of children under 5 with acute diarrhea was enrolled between Feb...

  4. Integrated Management Systems and Workflow-Based Electronic Document Management: An Empirical Study

    DEFF Research Database (Denmark)

    Pho, Hang Thu; Tambo, Torben

    2014-01-01

    trustworthiness. Social implications: IMS has a tendency to stay with professionals, e.g. line managers and QA/QC/QMS professionals. The EDMS line of discussion suggests a broader inclusion. Originality/value: Researching IMS as a technological implementation is giving a better platform of aligning the IMS...... (EDMS) is essential, especially at global enterprises where a large amount of documents generated by processes flows through different work cultures. However, there is no "one-size-fits-all" design for EDMS because it depends on organizations' needs, size and resource allocation. This article discusses...... the interrelation between EDMS and IMS in order to suggest a best practice. Design/methodology/approach: This article methodologically based upon a qualitative, interpretivistic, longitudinal empirical study in a wind turbine factory. Findings and Originality/value: IMS improvement and effectiveness has been...

  5. Trust in automation: integrating empirical evidence on factors that influence trust.

    Science.gov (United States)

    Hoff, Kevin Anthony; Bashir, Masooda

    2015-05-01

    We systematically review recent empirical research on factors that influence trust in automation to present a three-layered trust model that synthesizes existing knowledge. Much of the existing research on factors that guide human-automation interaction is centered around trust, a variable that often determines the willingness of human operators to rely on automation. Studies have utilized a variety of different automated systems in diverse experimental paradigms to identify factors that impact operators' trust. We performed a systematic review of empirical research on trust in automation from January 2002 to June 2013. Papers were deemed eligible only if they reported the results of a human-subjects experiment in which humans interacted with an automated system in order to achieve a goal. Additionally, a relationship between trust (or a trust-related behavior) and another variable had to be measured. All together, 101 total papers, containing 127 eligible studies, were included in the review. Our analysis revealed three layers of variability in human-automation trust (dispositional trust, situational trust, and learned trust), which we organize into a model. We propose design recommendations for creating trustworthy automation and identify environmental conditions that can affect the strength of the relationship between trust and reliance. Future research directions are also discussed for each layer of trust. Our three-layered trust model provides a new lens for conceptualizing the variability of trust in automation. Its structure can be applied to help guide future research and develop training interventions and design procedures that encourage appropriate trust. © 2014, Human Factors and Ergonomics Society.

  6. Empirical Analysis of the Integration Activity of Business Structures in the Regions of Russia

    Directory of Open Access Journals (Sweden)

    Maria Gennadyevna Karelina

    2015-12-01

    Full Text Available The article investigates the integration activity of business structures in the regions of Russia. A wide variety of approaches to the study of the problems and prospects of economic integration and the current dispute on the role of integration processes in the regional economic development have determined the complexity of the concepts “integration” and “integration activities” in order to develop the objective conditions to analyse the integration activity of business structures in the Russian regions. The monitoring of the current legal system of the Russian Federation carried out in the area of statistics and compiling statistical databases on mergers and acquisitions has showed the absence of the formal executive authority dealing with the compiling and collections of information on the integration activity at the regional level. In this connection, the data of Russian information and analytical agencies are made from the information and analytical base. As the research tools, the methods of analysis of structural changes, methods of analysis of economic differentiation and concentration, methods of non-parametric statistics are used. The article shows the close relationship between the social and economic development of the subjects of Russia and the integrated business structures functioning on its territory. An investigation of the integration activity structure and dynamics in the subjects of the Russian Federation based on the statistical data for the period from 2003 to 2012 has revealed the increasing heterogeneity of the integration activity of business structures in the regions of Russia. The hypothesis of a substantial divergence of mergers and acquisitions of corporate structures in the Russian regions was confirmed by the high values of the Gini coefficient, the Herfindahl index, and the decile coefficient of differentiation. The research results are of practical importance since they can be used to improve the existing

  7. An integrative literature review and empirical validation of motives for introducing shared services in government organizations

    NARCIS (Netherlands)

    Paagman, Arnaud; Tate, Mary; Furtmueller-Ettinger, Elfriede; de Bloom, Jessica

    2014-01-01

    This paper contributes to the understanding of the meaning of shared services and motives for introducing shared services in government organizations. We review and clarify definitions of shared services and derive a definition applicable for the government context. Based on an extensive literature

  8. An integrative literature review and empirical validation of motives for introducing shared services in government organizations

    NARCIS (Netherlands)

    Paagman, Arnaud; Tate, Mary; Furtmueller, Elfi; de Bloom, Jessica

    This paper contributes to the understanding of the meaning of shared services and motives for introducing shared services in government organizations. We review and clarify definitions of shared services and derive a definition applicable for the government context. Based on an extensive literature

  9. Testing an integrated model of operations capabilities An empirical study of Australian airlines

    NARCIS (Netherlands)

    Nand, Alka Ashwini; Singh, Prakash J.; Power, Damien

    2013-01-01

    Purpose - The purpose of this paper is to test the integrated model of operations strategy as proposed by Schmenner and Swink to explain whether firms trade-off or accumulate capabilities, taking into account their positions relative to their asset and operating frontiers.

  10. Students' Academic Performance and Various Cognitive Processes of Learning: An Integrative Framework and Empirical Analysis

    Science.gov (United States)

    Phan, Huy Phuong

    2010-01-01

    The main aim of this study is to test a conceptualised framework that involved the integration of achievement goals, self-efficacy and self-esteem beliefs, and study-processing strategies. Two hundred and ninety (178 females, 112 males) first-year university students were administered a number of Likert-scale inventories in tutorial classes. Data…

  11. Continuous integration in a social-coding world : empirical evidence from GitHub

    NARCIS (Netherlands)

    Vasilescu, B.N.; van Schuylenburg, S.B.; Wulms, Jules; Serebrenik, A.; Brand, van den M.G.J.

    2014-01-01

    Continuous integration is a software engineering practice of frequently merging all developer working copies with a shared main branch, e.g., several times a day. With the advent of GitHub, a platform well known for its "social coding" features that aid collaboration and sharing, and currently the

  12. The impact of continuous integration on other software development practices: a large-scale empirical study

    NARCIS (Netherlands)

    Zhao, Y.; Serebrenik, A.; Zhou, Y.; Filkov, V.; Vasilescu, B.N.

    2017-01-01

    Continuous Integration (CI) has become a disruptive innovation in software development: with proper tool support and adoption, positive effects have been demonstrated for pull request throughput and scaling up of project sizes. As any other innovation, adopting CI implies adapting existing practices

  13. Modelling Student Satisfaction and Motivation in the Integrated Educational Environment: An Empirical study

    Science.gov (United States)

    Stukalina, Yulia

    2016-01-01

    Purpose: The purpose of this paper is to explore some issues related to enhancing the quality of educational services provided by a university in the agenda of integrating quality assurance activities and strategic management procedures. Design/methodology/approach: Employing multiple regression analysis the author has examined some factors that…

  14. Learner Behaviour in a MOOC Practice-Oriented Course: In Empirical Study Integrating TAM and TPB

    Science.gov (United States)

    Yang, Hsi-Hsun; Su, Chung-Ho

    2017-01-01

    Few practice-oriented courses are currently integrated into online learning platforms, such as OpenCourseWare, Khan Academy, and Massive Open Online Courses (MOOCs). It is worthwhile to explore how learners respond to information technology and new teaching methods when practice-oriented course are placed online. Therefore, this study probes…

  15. Uncertainty in Measurement: A Review of Monte Carlo Simulation Using Microsoft Excel for the Calculation of Uncertainties Through Functional Relationships, Including Uncertainties in Empirically Derived Constants

    Science.gov (United States)

    Farrance, Ian; Frenkel, Robert

    2014-01-01

    The Guide to the Expression of Uncertainty in Measurement (usually referred to as the GUM) provides the basic framework for evaluating uncertainty in measurement. The GUM however does not always provide clearly identifiable procedures suitable for medical laboratory applications, particularly when internal quality control (IQC) is used to derive most of the uncertainty estimates. The GUM modelling approach requires advanced mathematical skills for many of its procedures, but Monte Carlo simulation (MCS) can be used as an alternative for many medical laboratory applications. In particular, calculations for determining how uncertainties in the input quantities to a functional relationship propagate through to the output can be accomplished using a readily available spreadsheet such as Microsoft Excel. The MCS procedure uses algorithmically generated pseudo-random numbers which are then forced to follow a prescribed probability distribution. When IQC data provide the uncertainty estimates the normal (Gaussian) distribution is generally considered appropriate, but MCS is by no means restricted to this particular case. With input variations simulated by random numbers, the functional relationship then provides the corresponding variations in the output in a manner which also provides its probability distribution. The MCS procedure thus provides output uncertainty estimates without the need for the differential equations associated with GUM modelling. The aim of this article is to demonstrate the ease with which Microsoft Excel (or a similar spreadsheet) can be used to provide an uncertainty estimate for measurands derived through a functional relationship. In addition, we also consider the relatively common situation where an empirically derived formula includes one or more ‘constants’, each of which has an empirically derived numerical value. Such empirically derived ‘constants’ must also have associated uncertainties which propagate through the functional

  16. Uncertainty in measurement: a review of monte carlo simulation using microsoft excel for the calculation of uncertainties through functional relationships, including uncertainties in empirically derived constants.

    Science.gov (United States)

    Farrance, Ian; Frenkel, Robert

    2014-02-01

    The Guide to the Expression of Uncertainty in Measurement (usually referred to as the GUM) provides the basic framework for evaluating uncertainty in measurement. The GUM however does not always provide clearly identifiable procedures suitable for medical laboratory applications, particularly when internal quality control (IQC) is used to derive most of the uncertainty estimates. The GUM modelling approach requires advanced mathematical skills for many of its procedures, but Monte Carlo simulation (MCS) can be used as an alternative for many medical laboratory applications. In particular, calculations for determining how uncertainties in the input quantities to a functional relationship propagate through to the output can be accomplished using a readily available spreadsheet such as Microsoft Excel. The MCS procedure uses algorithmically generated pseudo-random numbers which are then forced to follow a prescribed probability distribution. When IQC data provide the uncertainty estimates the normal (Gaussian) distribution is generally considered appropriate, but MCS is by no means restricted to this particular case. With input variations simulated by random numbers, the functional relationship then provides the corresponding variations in the output in a manner which also provides its probability distribution. The MCS procedure thus provides output uncertainty estimates without the need for the differential equations associated with GUM modelling. The aim of this article is to demonstrate the ease with which Microsoft Excel (or a similar spreadsheet) can be used to provide an uncertainty estimate for measurands derived through a functional relationship. In addition, we also consider the relatively common situation where an empirically derived formula includes one or more 'constants', each of which has an empirically derived numerical value. Such empirically derived 'constants' must also have associated uncertainties which propagate through the functional relationship

  17. Properties of the HII Regions Derived Using Integral Field Spectroscopy

    Directory of Open Access Journals (Sweden)

    Sebastian F. Sánchez

    2013-01-01

    Full Text Available Here we review some of our more recent results on the observed properties of HII regions using Integral Field Spectroscopy. In particular, we illustrate the use of this technique to study in detail the ionization conditions across the nebulae for galactic HII regions (focused on the Orion Nebula and the statistical study of large samples of extragalactic HII regions. We review the reported new scaling relation between the local mass density and the oxygen abundance across the disk galaxies and the recently discovered universal gradient for oxygen abundances. We update our previous results the lack of a dependence of the Mass-Metallicity relation with the starformation rate, including new unpublished data. Finally we discuss on the relation between the ionization conditions in the nebulae and the underlying stellar population. All together our results indicate that disk galaxies present a chemical enrichment dominated by an inside-out growth scenario, with a less evident effect of radial migrations and/or outflows.

  18. What does materiality mean to integrated reporting preparers? An empirical exploration

    OpenAIRE

    Lai, Alessandro; Melloni, Gaia; Stacchezzini, Riccardo

    2017-01-01

    Purpose—This paper seeks to understand how the principle of materiality gets implemented in integrated reporting contexts. Design/methodology/approach—Drawing on an interpretation of materiality as a social construction, this research explores the meaning that practitioners attach to the principle during their implementation of it. Following an existing framework for exploring materiality in corporate reporting, this study investigates the meaning by focusing on who participates in determinin...

  19. Modified Bessel P-integrals and P-derivatives and their properties

    International Nuclear Information System (INIS)

    Volosivets, S S

    2014-01-01

    We study the modified Bessel P-integral, whose properties are similar to those of the Bessel potential, and the modified Bessel P-derivative. These operators are inverse to each other. We prove analogues of the embedding theorems of Hardy, Littlewood, Stein, Zygmund and Lizorkin concerning the images of L p (R) under the action of Bessel potentials. We give applications of the Bessel integral and derivative to the integrability of the P-adic Fourier transform and to approximation theory (an embedding theorem of Ul'yanov type)

  20. A Novel Multiscale Ensemble Carbon Price Prediction Model Integrating Empirical Mode Decomposition, Genetic Algorithm and Artificial Neural Network

    Directory of Open Access Journals (Sweden)

    Bangzhu Zhu

    2012-02-01

    Full Text Available Due to the movement and complexity of the carbon market, traditional monoscale forecasting approaches often fail to capture its nonstationary and nonlinear properties and accurately describe its moving tendencies. In this study, a multiscale ensemble forecasting model integrating empirical mode decomposition (EMD, genetic algorithm (GA and artificial neural network (ANN is proposed to forecast carbon price. Firstly, the proposed model uses EMD to decompose carbon price data into several intrinsic mode functions (IMFs and one residue. Then, the IMFs and residue are composed into a high frequency component, a low frequency component and a trend component which have similar frequency characteristics, simple components and strong regularity using the fine-to-coarse reconstruction algorithm. Finally, those three components are predicted using an ANN trained by GA, i.e., a GAANN model, and the final forecasting results can be obtained by the sum of these three forecasting results. For verification and testing, two main carbon future prices with different maturity in the European Climate Exchange (ECX are used to test the effectiveness of the proposed multiscale ensemble forecasting model. Empirical results obtained demonstrate that the proposed multiscale ensemble forecasting model can outperform the single random walk (RW, ARIMA, ANN and GAANN models without EMD preprocessing and the ensemble ARIMA model with EMD preprocessing.

  1. Design Integration - a theroretical and empirical study of design integration in small and medium sized Danish companies

    DEFF Research Database (Denmark)

    Erichsen, Pia Geisby

    er drivkræft. Afhandlingen bidrager til design management feltet med en ny måde at tale om og forstå design integration. Yderligere bidrager den med ny viden omkring dynamikken omkring design integration. Sidst men ikke mindst biddrager den til, at designledelseskonsulenter samt små og mellemstore...... organisatorisk kontekst?’ - blev søgt besvaret gennem to litteraturstudier af henholdsvis design management og design. Litteraturstudiet af design management gav imidlertid kun begrænsede svar på spørgsmålet ’hvad er design?’. Designfeltet derimod kunne give et mere nuanceret svar, hvilket resulterede i en ny...... blev det identificeret, at det var relevant, at se på barrierer og drivkræfter et dynamisk perspektiv. Via observationsstudiet blev designtrappen identificeret som relevant i forhold til forskningsspørgsmålet, men modellen havde også nogle indbyggede barrierer, hvorfor der blev søgt efter andre...

  2. Psychological Models of Art Reception must be Empirically Grounded

    DEFF Research Database (Denmark)

    Nadal, Marcos; Vartanian, Oshin; Skov, Martin

    2017-01-01

    We commend Menninghaus et al. for tackling the role of negative emotions in art reception. However, their model suffers from shortcomings that reduce its applicability to empirical studies of the arts: poor use of evidence, lack of integration with other models, and limited derivation of testable...... hypotheses. We argue that theories about art experiences should be based on empirical evidence....

  3. Empirical Analysis of the Variability of Wind Generation in India: Implications for Grid Integration

    Energy Technology Data Exchange (ETDEWEB)

    Phadke, Amol; Abhyankar, NIkit; Rao, Poorvi

    2014-06-17

    We analyze variability in load and wind generation in India to assess its implications for grid integration of large scale wind projects using actual wind generation and load data from two states in India, Karnataka and Tamil Nadu. We compare the largest variations in load and net load (load ?wind, i.e., load after integrating wind) that the generation fleet has to meet. In Tamil Nadu, where wind capacity is about 53percent of the peak demand, we find that the additional variation added due to wind over the current variation in load is modest; if wind penetration reaches 15percent and 30percent by energy, the additional hourly variation is less than 0.5percent and 4.5percent of the peak demand respectively for 99percent of the time. For wind penetration of 15percent by energy, Tamil Nadu system is found to be capable of meeting the additional ramping requirement for 98.8percent of the time. Potential higher uncertainty in net load compared to load is found to have limited impact on ramping capability requirements of the system if coal plants can me ramped down to 50percent of their capacity. Load and wind aggregation in Tamil Nadu and Karnataka is found to lower the variation by at least 20percent indicating the benefits geographic diversification. These findings suggest modest additional flexible capacity requirements and costs for absorbing variation in wind power and indicate that the potential capacity support (if wind does not generate enough during peak periods) may be the issue that has more bearing on the economics of integrating wind

  4. Pharmacological Classification and Activity Evaluation of Furan and Thiophene Amide Derivatives Applying Semi-Empirical ab initio Molecular Modeling Methods

    Directory of Open Access Journals (Sweden)

    Leszek Bober

    2012-05-01

    Full Text Available Pharmacological and physicochemical classification of the furan and thiophene amide derivatives by multiple regression analysis and partial least square (PLS based on semi-empirical ab initio molecular modeling studies and high-performance liquid chromatography (HPLC retention data is proposed. Structural parameters obtained from the PCM (Polarizable Continuum Model method and the literature values of biological activity (antiproliferative for the A431 cells expressed as LD50 of the examined furan and thiophene derivatives was used to search for relationships. It was tested how variable molecular modeling conditions considered together, with or without HPLC retention data, allow evaluation of the structural recognition of furan and thiophene derivatives with respect to their pharmacological properties.

  5. High Entrepreneurship, Leadership, and Professionalism (HELP): Toward an Integrated, Empirically Based Perspective

    Science.gov (United States)

    Di Fabio, Annamaria; Bucci, Ornella; Gori, Alessio

    2016-01-01

    This article evaluates the psychometric properties of a new measure for assessing the constructs of entrepreneurship, leadership, and professionalism, from an integrated point of view, the High Entrepreneurship, Leadership and Professionalism Questionnaire (HELP-Q). Exploratory factor analysis indicated a factor structure with three principal dimensions, and confirmatory factor analysis and goodness of fit indices indicated a good fit of the model to the data. All the dimensions showed good values of internal consistency. The results of the study thus indicate that the HELP-Q is a short and easily administered instrument with good psychometric properties that can promote entrepreneurship, leadership, and professionalism in workers as well as in those who are preparing to enter the turbulent 21st century labor market. PMID:27933015

  6. High Entrepreneurship, Leadership, and Professionalism (HELP): Toward an Integrated, Empirically Based Perspective.

    Science.gov (United States)

    Di Fabio, Annamaria; Bucci, Ornella; Gori, Alessio

    2016-01-01

    This article evaluates the psychometric properties of a new measure for assessing the constructs of entrepreneurship, leadership, and professionalism, from an integrated point of view, the High Entrepreneurship, Leadership and Professionalism Questionnaire (HELP-Q). Exploratory factor analysis indicated a factor structure with three principal dimensions, and confirmatory factor analysis and goodness of fit indices indicated a good fit of the model to the data. All the dimensions showed good values of internal consistency. The results of the study thus indicate that the HELP-Q is a short and easily administered instrument with good psychometric properties that can promote entrepreneurship, leadership, and professionalism in workers as well as in those who are preparing to enter the turbulent 21st century labor market.

  7. High Entrepreneurship, Leadership, and Professionalism (HELP: towards an integrated, empirically based perspective

    Directory of Open Access Journals (Sweden)

    Annamaria Di Fabio

    2016-11-01

    Full Text Available This article evaluates the psychometric properties of a new measure for assessing the constructs of entrepreneurship, leadership, and professionalism, from an integrated point of view, the High Entrepreneurship, Leadership and Professionalism Questionnaire (HELP-Q. Exploratory factor analysis indicated a factor structure with three principal dimensions, and confirmatory factor analysis and goodness of fit indices indicated a good fit of the model to the data. All the dimensions showed good values of internal consistency. The results of the study thus indicate that the HELP-Q is a short and easily administered instrument with good psychometric properties that can promote entrepreneurship, leadership, and professionalism in workers as well as in those who are preparing to enter the turbulent 21st century labor market.

  8. Nurses' resilience and the emotional labour of nursing work: An integrative review of empirical literature.

    Science.gov (United States)

    Delgado, Cynthia; Upton, Dominic; Ranse, Kristen; Furness, Trentham; Foster, Kim

    2017-05-01

    The emotional labour of nursing work involves managing the emotional demands of relating with patients, families and colleagues. Building nurses' resilience is an important strategy in mitigating the stress and burnout that may be caused by ongoing exposure to these demands. Understandings of resilience in the context of emotional labour in nursing, however, are limited. To investigate the state of knowledge on resilience in the context of emotional labour in nursing. Integrative literature review. CINAHL, Medline, Scopus, and PsycINFO electronic databases were searched for abstracts published between 2005 and 2015 and written in English. Reference lists were hand searched. Whittemore and Knafl's integrative review method was used to guide this review. The constant comparative method was used to analyze and synthesize data from 27 peer-reviewed quantitative and qualitative articles. Methodological quality of included studies was assessed using the Mixed Methods Assessment Tool. Emotional labour is a facet of all aspects of nursing work and nurse-patient/family/collegial interactions. Emotional dissonance arising from surface acting in emotional labour can lead to stress and burnout. Resilience can be a protective process for the negative effects of emotional labour. Several resilience interventions have been designed to strengthen nurses' individual resources and reduce the negative effects of workplace stress; however they do not specifically address emotional labour. Inclusion of emotional labour-mitigating strategies is recommended for future resilience interventions. Resilience is a significant intervention that can build nurses' resources and address the effects of emotional dissonance in nursing work. There is a need for further investigation of the relationship between resilience and emotional labour in nursing, and robust evaluation of the impact of resilience interventions that address emotional labour. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Estimation of Aboveground Biomass in Alpine Forests: A Semi-Empirical Approach Considering Canopy Transparency Derived from Airborne LiDAR Data

    Directory of Open Access Journals (Sweden)

    Martin Rutzinger

    2010-12-01

    Full Text Available In this study, a semi-empirical model that was originally developed for stem volume estimation is used for aboveground biomass (AGB estimation of a spruce dominated alpine forest. The reference AGB of the available sample plots is calculated from forest inventory data by means of biomass expansion factors. Furthermore, the semi-empirical model is extended by three different canopy transparency parameters derived from airborne LiDAR data. These parameters have not been considered for stem volume estimation until now and are introduced in order to investigate the behavior of the model concerning AGB estimation. The developed additional input parameters are based on the assumption that transparency of vegetation can be measured by determining the penetration of the laser beams through the canopy. These parameters are calculated for every single point within the 3D point cloud in order to consider the varying properties of the vegetation in an appropriate way. Exploratory Data Analysis (EDA is performed to evaluate the influence of the additional LiDAR derived canopy transparency parameters for AGB estimation. The study is carried out in a 560 km2 alpine area in Austria, where reference forest inventory data and LiDAR data are available. The investigations show that the introduction of the canopy transparency parameters does not change the results significantly according to R2 (R2 = 0.70 to R2 = 0.71 in comparison to the results derived from, the semi-empirical model, which was originally developed for stem volume estimation.

  10. EMPIRICAL TESTING OF MODIFIED BLACK-SCHOLES OPTION PRICING MODEL FORMULA ON NSE DERIVATIVE MARKET IN INDIA

    Directory of Open Access Journals (Sweden)

    Ambrish Gupta

    2013-01-01

    Full Text Available The main objectives of this paper are to incorporate modification in Black-Scholes option pricing model formula by adding some new variables on the basis of given assumption related to risk-free interest rate, and also shows the calculation process of new risk-free interest rate on the basis of modified variable. This paper also identifies the various situations in empirical testing of modified and original Black-Scholes formula with respect to the market value on the basis of assumed and calculated risk-free interest rate.

  11. Derivative Process Model of Development Power in Industry: Empirical Research and Forecast for Chinese Software Industry and US Economy

    OpenAIRE

    Feng Dai; Bao- hua Sun; Jie Sun

    2004-01-01

    Based on concept and theory of Development Power [1], this paper analyzes the transferability and the diffusibility of industrial development power, points out that the chaos is the extreme of DP releasing and order is the highest degree of DP accumulating, puts forward A-C strength, the index of adjusting and controlling strength, and sets up the derivative process model for industrial development power on the Partial Distribution [2]-[4]. By the derivative process model, a kind of time seri...

  12. An Integrated Diagnostic Framework to Manage Organization Sustainable Growth: An Empirical Case

    Directory of Open Access Journals (Sweden)

    Jingxiao Zhang

    2016-03-01

    Full Text Available This research aims to develop a quantitative diagnostic framework by combining the Weisbord six-box model with the growth management model to focus on an organization’s internally driven sustainable management system. The research adopted an instrument developed by Preziosi and an extended Weisbord six-box model. The research employed a survey to collect 180 samples in a Chinese petrol company and applied the comparative method: (a the average score method; and (b the entropy method to confirm the growth level of the company. The survey also attempted to identify corresponding top growth influence factors using the obstacle degree formula. The results showed that the integrated diagnostic framework worked well to diagnose a regional but large Chinese petroleum company. In other words, the research successfully quantified the growth position and top influence factors and helped put forward specific suggestions to drive the organization of sustainable development. The method confirmed this organization during the fourth phase of five phases. In addition, top influence factors hindering the internal growth were (a the lack of task engagement with energy and time; (b the lack of personal work units; and (c a poor division of labor for reaching sustainable growth rates. The research provides a generic theoretical framework support to incorporate growth management models into an organizational diagnosis to obtain sustainable growth. It further highlights and practices guidelines in examining actual growth management levels in companies and discusses top influence factors to design efficient management systems to pursue organizational growth in a multitude of industrial contexts.

  13. Integral definition of the logarithmic function and the derivative of the exponential function in calculus

    Science.gov (United States)

    Vaninsky, Alexander

    2015-04-01

    Defining the logarithmic function as a definite integral with a variable upper limit, an approach used by some popular calculus textbooks, is problematic. We discuss the disadvantages of such a definition and provide a way to fix the problem. We also consider a definition-based, rigorous derivation of the derivative of the exponential function that is easier, more intuitive, and complies with the standard definitions of the number e, the logarithmic, and the exponential functions.

  14. Second-order domain derivative of normal-dependent boundary integrals

    KAUST Repository

    Balzer, Jonathan

    2010-03-17

    Numerous reconstruction tasks in (optical) surface metrology allow for a variational formulation. The occurring boundary integrals may be interpreted as shape functions. The paper is concerned with the second-order analysis of such functions. Shape Hessians of boundary integrals are considered difficult to find analytically because they correspond to third-order derivatives of an, in a sense equivalent, domain integral. We complement previous results by considering cost functions depending explicitly on the surface normal. The correctness and practicability of our calculations are verified in the context of a Newton-type shape reconstruction method. © 2010 Birkhäuser / Springer Basel AG.

  15. On the integration of an ODE involving the derivative of a Preisach nonlinearity

    International Nuclear Information System (INIS)

    Flynn, D; Rasskazov, O

    2005-01-01

    We offer an algorithm for numerical integration of an ODE with a Preisach nonlinearity under the derivative on the left-hand side. Despite the exotic form, equations of that kind are important in applied disciplines, for example in terrestrial hydrology

  16. Feasibility of real-time calculation of correlation integral derived statistics applied to EGG time series

    NARCIS (Netherlands)

    van den Broek, PLC; van Egmond, J; van Rijn, CM; Takens, F; Coenen, AML; Booij, LHDJ

    2005-01-01

    Background: This study assessed the feasibility of online calculation of the correlation integral (C(r)) aiming to apply C(r)derived statistics. For real-time application it is important to reduce calculation time. It is shown how our method works for EEG time series. Methods: To achieve online

  17. Feasibility of real-time calculation of correlation integral derived statistics applied to EEG time series

    NARCIS (Netherlands)

    Broek, P.L.C. van den; Egmond, J. van; Rijn, C.M. van; Takens, F.; Coenen, A.M.L.; Booij, L.H.D.J.

    2005-01-01

    This study assessed the feasibility of online calculation of the correlation integral (C(r)) aiming to apply C(r)-derived statistics. For real-time application it is important to reduce calculation time. It is shown how our method works for EEG time series. Methods: To achieve online calculation of

  18. Intercomparison of derived integral data from evaluated data libraries of the actinides

    International Nuclear Information System (INIS)

    Paviotti Corcuera, R.

    1988-12-01

    Resonance integrals and fission spectrum averaged cross-sections are calculated for the actinides from all recent major evaluated libraries. Whenever possible the results are compared against measurements. It is found that the experimental data are scarce and that there exist considerable differences between experimentally measured data and those derived from the evaluated libraries. (author). 93 refs and tabs

  19. Occupations at Risk and Organizational Well-Being: An Empirical Test of a Job Insecurity Integrated Model.

    Science.gov (United States)

    Chirumbolo, Antonio; Urbini, Flavio; Callea, Antonino; Lo Presti, Alessandro; Talamo, Alessandra

    2017-01-01

    One of the more visible effects of the societal changes is the increased feelings of uncertainty in the workforce. In fact, job insecurity represents a crucial occupational risk factor and a major job stressor that has negative consequences on both organizational well-being and individual health. Many studies have focused on the consequences about the fear and the perception of losing the job as a whole (called quantitative job insecurity), while more recently research has begun to examine more extensively the worries and the perceptions of losing valued job features (called qualitative job insecurity). The vast majority of the studies, however, have investigated the effects of quantitative and qualitative job insecurity separately. In this paper, we proposed the Job Insecurity Integrated Model aimed to examine the effects of quantitative job insecurity and qualitative job insecurity on their short-term and long-term outcomes. This model was empirically tested in two independent studies, hypothesizing that qualitative job insecurity mediated the effects of quantitative job insecurity on different outcomes, such as work engagement and organizational identification (Study 1), and job satisfaction, commitment, psychological stress and turnover intention (Study 2). Study 1 was conducted on 329 employees in private firms, while Study 2 on 278 employees in both public sector and private firms. Results robustly showed that qualitative job insecurity totally mediated the effects of quantitative on all the considered outcomes. By showing that the effects of quantitative job insecurity on its outcomes passed through qualitative job insecurity, the Job Insecurity Integrated Model contributes to clarifying previous findings in job insecurity research and puts forward a framework that could profitably produce new investigations with important theoretical and practical implications.

  20. Occupations at Risk and Organizational Well-Being: An Empirical Test of a Job Insecurity Integrated Model

    Science.gov (United States)

    Chirumbolo, Antonio; Urbini, Flavio; Callea, Antonino; Lo Presti, Alessandro; Talamo, Alessandra

    2017-01-01

    One of the more visible effects of the societal changes is the increased feelings of uncertainty in the workforce. In fact, job insecurity represents a crucial occupational risk factor and a major job stressor that has negative consequences on both organizational well-being and individual health. Many studies have focused on the consequences about the fear and the perception of losing the job as a whole (called quantitative job insecurity), while more recently research has begun to examine more extensively the worries and the perceptions of losing valued job features (called qualitative job insecurity). The vast majority of the studies, however, have investigated the effects of quantitative and qualitative job insecurity separately. In this paper, we proposed the Job Insecurity Integrated Model aimed to examine the effects of quantitative job insecurity and qualitative job insecurity on their short-term and long-term outcomes. This model was empirically tested in two independent studies, hypothesizing that qualitative job insecurity mediated the effects of quantitative job insecurity on different outcomes, such as work engagement and organizational identification (Study 1), and job satisfaction, commitment, psychological stress and turnover intention (Study 2). Study 1 was conducted on 329 employees in private firms, while Study 2 on 278 employees in both public sector and private firms. Results robustly showed that qualitative job insecurity totally mediated the effects of quantitative on all the considered outcomes. By showing that the effects of quantitative job insecurity on its outcomes passed through qualitative job insecurity, the Job Insecurity Integrated Model contributes to clarifying previous findings in job insecurity research and puts forward a framework that could profitably produce new investigations with important theoretical and practical implications. PMID:29250013

  1. Occupations at Risk and Organizational Well-Being: An Empirical Test of a Job Insecurity Integrated Model

    Directory of Open Access Journals (Sweden)

    Antonio Chirumbolo

    2017-11-01

    Full Text Available One of the more visible effects of the societal changes is the increased feelings of uncertainty in the workforce. In fact, job insecurity represents a crucial occupational risk factor and a major job stressor that has negative consequences on both organizational well-being and individual health. Many studies have focused on the consequences about the fear and the perception of losing the job as a whole (called quantitative job insecurity, while more recently research has begun to examine more extensively the worries and the perceptions of losing valued job features (called qualitative job insecurity. The vast majority of the studies, however, have investigated the effects of quantitative and qualitative job insecurity separately. In this paper, we proposed the Job Insecurity Integrated Model aimed to examine the effects of quantitative job insecurity and qualitative job insecurity on their short-term and long-term outcomes. This model was empirically tested in two independent studies, hypothesizing that qualitative job insecurity mediated the effects of quantitative job insecurity on different outcomes, such as work engagement and organizational identification (Study 1, and job satisfaction, commitment, psychological stress and turnover intention (Study 2. Study 1 was conducted on 329 employees in private firms, while Study 2 on 278 employees in both public sector and private firms. Results robustly showed that qualitative job insecurity totally mediated the effects of quantitative on all the considered outcomes. By showing that the effects of quantitative job insecurity on its outcomes passed through qualitative job insecurity, the Job Insecurity Integrated Model contributes to clarifying previous findings in job insecurity research and puts forward a framework that could profitably produce new investigations with important theoretical and practical implications.

  2. On the evaluation of social innovations and social enterprises: Recognizing and integrating two solitudes in the empirical knowledge base.

    Science.gov (United States)

    Szijarto, Barbara; Milley, Peter; Svensson, Kate; Cousins, J Bradley

    2018-02-01

    Social innovation (SI) is billed as a new way to address complex social problems. Interest in SI has intensified rapidly in the last decade, making it an important area of practice for evaluators, but a difficult one to navigate. Learning from developments in SI and evaluation approaches applied in SI contexts is challenging because of 'fuzzy' concepts and silos of activity and knowledge within SI communities. This study presents findings from a systematic review and integration of 41 empirical studies on evaluation in SI contexts. We identify two isolated conversations: one about 'social enterprises' (SEs) and the other about non-SE 'social innovations'. These conversations diverge in key areas, including engagement with evaluation scholarship, and in the reported purposes, approaches and use of evaluation. We identified striking differences with respect to degree of interest in collaborative approaches and facilitation of evaluation use. The findings speak to trends and debates in our field, for example how evaluation might reconcile divergent information needs in multilevel, cross-sectoral collaborations and respond to fluidity and change in innovative settings. Implications for practitioners and commissioners of evaluation include how evaluation is used in different contexts and the voice of evaluators (and the evaluation profession) in these conversations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Performing derivative and integral operations for optical waves with optical metamaterials

    Energy Technology Data Exchange (ETDEWEB)

    Dai, Cun-Li [College of Engineering, Nanjing Agriculture University, Nanjing Jiangsu, 210031 (China); College of Science, Nanjing Agriculture University, Nanjing Jiangsu, 210095 (China); Zhao, Zhi-Gang; Li, Xiao-Lin [College of Engineering, Nanjing Agriculture University, Nanjing Jiangsu, 210031 (China); Yang, Hong-Wei, E-mail: phd_hwyang@njau.edu.cn [College of Science, Nanjing Agriculture University, Nanjing Jiangsu, 210095 (China)

    2016-12-01

    The graded refractive index waveguides can perform Fourier transform for an optical wave. According to this characteristic, simpler optical metamaterials with three waveguides are theoretically proposed, in which all of the waveguides are materials with a positive refractive index. By selecting the appropriate refractive index and structure size, the theory and simulations demonstrated that these metamaterials can perform mathematical operations for the outline of incident optical waves, including the first-order derivative, second-order derivative and the integral. - Highlights: • The derivative and integral operations of optical waves are achieved with a simpler model. • Both negative and positive refractive index boast the same functions. • The mathematical operations can be implemented only by changing the refractive index of the intermediate material. • The results will greatly expand the possible applications, including photon computers, picture processing, video displays and data storage.

  4. Feynman path integral application on deriving black-scholes diffusion equation for european option pricing

    International Nuclear Information System (INIS)

    Utama, Briandhika; Purqon, Acep

    2016-01-01

    Path Integral is a method to transform a function from its initial condition to final condition through multiplying its initial condition with the transition probability function, known as propagator. At the early development, several studies focused to apply this method for solving problems only in Quantum Mechanics. Nevertheless, Path Integral could also apply to other subjects with some modifications in the propagator function. In this study, we investigate the application of Path Integral method in financial derivatives, stock options. Black-Scholes Model (Nobel 1997) was a beginning anchor in Option Pricing study. Though this model did not successfully predict option price perfectly, especially because its sensitivity for the major changing on market, Black-Scholes Model still is a legitimate equation in pricing an option. The derivation of Black-Scholes has a high difficulty level because it is a stochastic partial differential equation. Black-Scholes equation has a similar principle with Path Integral, where in Black-Scholes the share's initial price is transformed to its final price. The Black-Scholes propagator function then derived by introducing a modified Lagrange based on Black-Scholes equation. Furthermore, we study the correlation between path integral analytical solution and Monte-Carlo numeric solution to find the similarity between this two methods. (paper)

  5. An empirically-derived approach for investigating Health Information Technology: the Elementally Entangled Organisational Communication (EEOC) framework.

    Science.gov (United States)

    Georgiou, Andrew; Westbrook, Johanna I; Braithwaite, Jeffrey

    2012-07-12

    The purpose of this paper is to illustrate the Elementally Entangled Organisational Communication (EEOC) framework by drawing on a set of three case studies which assessed the impact of new Health Information Technology (HIT) on a pathology service. The EEOC framework was empirically developed as a tool to tackle organisational communication challenges in the implementation and evaluation of health information systems. The framework was synthesised from multiple research studies undertaken across a major metropolitan hospital pathology service during the period 2005 to 2008. These studies evaluated the impact of new HIT systems in pathology departments (Laboratory Information System) and an Emergency Department (Computerised Provider Order Entry) located in Sydney, Australia. Key dimensions of EEOC are illustrated by the following case studies: 1) the communication infrastructure between the Blood Bank and the ward for the coordination and distribution of blood products; 2) the organisational environment in the Clinical Chemistry and Haematology departments and their attempts to organise, plan and control the processing of laboratory specimens; and 3) the temporal make up of the organisation as revealed in changes to the way the Central Specimen Reception allocated, sequenced and synchronised work tasks. The case studies not only highlight the pre-existing communication architecture within the organisation but also the constitutive role communication plays in the way organisations go about addressing their requirements. HIT implementation involves a mutual transformation of the organisation and the technology. This is a vital consideration because of the dangers associated with poor organisational planning and implementation of HIT, and the potential for unintended adverse consequences, workarounds and risks to the quality and safety of patient care. The EEOC framework aims to account for the complex range of contextual factors and triggers that play a role in the

  6. Construction of integrable model Kohn-Sham potentials by analysis of the structure of functional derivatives

    International Nuclear Information System (INIS)

    Gaiduk, Alex P.; Staroverov, Viktor N.

    2011-01-01

    A directly approximated exchange-correlation potential should, by construction, be a functional derivative of some density functional in order to avoid unphysical results. Using generalized gradient approximations (GGAs) as an example, we show that functional derivatives of explicit density functionals have a very rigid inner structure, the knowledge of which allows one to build the entire functional derivative from a small part. Based on this analysis, we develop a method for direct construction of integrable Kohn-Sham potentials. As an illustration, we transform the model potential of van Leeuwen and Baerends (which is not a functional derivative) into a semilocal exchange potential that has a parent GGA, yields accurate energies, and is free from the artifacts inherent in existing semilocal potential approximations.

  7. Empirical Hamiltonians

    International Nuclear Information System (INIS)

    Peggs, S.; Talman, R.

    1987-01-01

    As proton accelerators get larger, and include more magnets, the conventional tracking programs which simulate them run slower. The purpose of this paper is to describe a method, still under development, in which element-by-element tracking around one turn is replaced by a single man, which can be processed far faster. It is assumed for this method that a conventional program exists which can perform faithful tracking in the lattice under study for some hundreds of turns, with all lattice parameters held constant. An empirical map is then generated by comparison with the tracking program. A procedure has been outlined for determining an empirical Hamiltonian, which can represent motion through many nonlinear kicks, by taking data from a conventional tracking program. Though derived by an approximate method this Hamiltonian is analytic in form and can be subjected to further analysis of varying degrees of mathematical rigor. Even though the empirical procedure has only been described in one transverse dimension, there is good reason to hope that it can be extended to include two transverse dimensions, so that it can become a more practical tool in realistic cases

  8. Identifying nurse staffing research in Medline: development and testing of empirically derived search strategies with the PubMed interface.

    Science.gov (United States)

    Simon, Michael; Hausner, Elke; Klaus, Susan F; Dunton, Nancy E

    2010-08-23

    term "nurse staffing") could improve the precision of future searches in this field. Empirically selected search terms can help to develop effective search strategies. The high consistency between all test sets confirmed the validity of our approach.

  9. The Cognitive Assessment Interview (CAI): development and validation of an empirically derived, brief interview-based measure of cognition.

    Science.gov (United States)

    Ventura, Joseph; Reise, Steven P; Keefe, Richard S E; Baade, Lyle E; Gold, James M; Green, Michael F; Kern, Robert S; Mesholam-Gately, Raquelle; Nuechterlein, Keith H; Seidman, Larry J; Bilder, Robert M

    2010-08-01

    Practical, reliable "real world" measures of cognition are needed to supplement neurocognitive performance data to evaluate possible efficacy of new drugs targeting cognitive deficits associated with schizophrenia. Because interview-based measures of cognition offer one possible approach, data from the MATRICS initiative (n=176) were used to examine the psychometric properties of the Schizophrenia Cognition Rating Scale (SCoRS) and the Clinical Global Impression of Cognition in Schizophrenia (CGI-CogS). We used classical test theory methods and item response theory to derive the 10-item Cognitive Assessment Interview (CAI) from the SCoRS and CGI-CogS ("parent instruments"). Sources of information for CAI ratings included the patient and an informant. Validity analyses examined the relationship between the CAI and objective measures of cognitive functioning, intermediate measures of cognition, and functional outcome. The rater's score from the newly derived CAI (10 items) correlate highly (r=.87) with those from the combined set of the SCoRS and CGI-CogS (41 items). Both the patient (r=.82) and the informant (r=.95) data were highly correlated with the rater's score. The CAI was modestly correlated with objectively measured neurocognition (r=-.32), functional capacity (r=-.44), and functional outcome (r=-.32), which was comparable to the parent instruments. The CAI allows for expert judgment in evaluating a patient's cognitive functioning and was modestly correlated with neurocognitive functioning, functional capacity, and functional outcome. The CAI is a brief, repeatable, and potentially valuable tool for rating cognition in schizophrenia patients who are participating in clinical trials. Copyright 2010 Elsevier B.V. All rights reserved.

  10. An Integrative Review of Empirical Research on Perceptions and Behaviors Related to Prescribed Burning and Wildfire in the United States

    Science.gov (United States)

    Dupéy, Lauren Nicole; Smith, Jordan W.

    2018-06-01

    Social science research from a variety of disciplines has generated a collective understanding of how individuals prepare for, and respond to, the risks associated with prescribed burning and wildfire. We provide a systematic compilation, review, and quantification of dominant trends in this literature by collecting all empirical research conducted within the U.S. that has addressed perceptions and behaviors surrounding various aspects of prescribed burning and wildfire. We reviewed and quantified this literature using four thematic categories covering: (1) the theory and methods that have been used in previous research; (2) the psychosocial aspects of prescribed burning and wildfire that have been studied; (3) the biophysical characteristics of the fires which have been studied; and (4) the types of fire and management approaches that have been examined. Our integrative review builds on previous literature reviews on the subject by offering new insight on the dominant trends, underutilized approaches, and under-studied topics within each thematic category. For example, we found that a select set of theories (e.g., Protection Motivation Theory, Attribution Theory, etc.) and approaches (e.g., mixed-methods) have only been used sparingly in previous research, even though these theories and approaches can produce insightful results that can readily be implemented by fire-management professionals and decision makers. By identifying trends and gaps in the literature across the thematic categories, we were able to answer four questions that address how future research can make the greatest contribution to our understanding of perceptions and behaviors related to prescribed burning and wildfire.

  11. An Integrative Review of Empirical Research on Perceptions and Behaviors Related to Prescribed Burning and Wildfire in the United States.

    Science.gov (United States)

    Dupéy, Lauren Nicole; Smith, Jordan W

    2018-06-01

    Social science research from a variety of disciplines has generated a collective understanding of how individuals prepare for, and respond to, the risks associated with prescribed burning and wildfire. We provide a systematic compilation, review, and quantification of dominant trends in this literature by collecting all empirical research conducted within the U.S. that has addressed perceptions and behaviors surrounding various aspects of prescribed burning and wildfire. We reviewed and quantified this literature using four thematic categories covering: (1) the theory and methods that have been used in previous research; (2) the psychosocial aspects of prescribed burning and wildfire that have been studied; (3) the biophysical characteristics of the fires which have been studied; and (4) the types of fire and management approaches that have been examined. Our integrative review builds on previous literature reviews on the subject by offering new insight on the dominant trends, underutilized approaches, and under-studied topics within each thematic category. For example, we found that a select set of theories (e.g., Protection Motivation Theory, Attribution Theory, etc.) and approaches (e.g., mixed-methods) have only been used sparingly in previous research, even though these theories and approaches can produce insightful results that can readily be implemented by fire-management professionals and decision makers. By identifying trends and gaps in the literature across the thematic categories, we were able to answer four questions that address how future research can make the greatest contribution to our understanding of perceptions and behaviors related to prescribed burning and wildfire.

  12. Association of Empirically Derived Dietary Patterns with Cardiovascular Risk Factors: A Comparison of PCA and RRR Methods.

    Directory of Open Access Journals (Sweden)

    Nicolas Sauvageot

    Full Text Available Principal component analysis is used to determine dietary behaviors of a population whereas reduced rank regression is used to construct disease-related dietary patterns. This study aimed to compare both types of DP and theirs associations with cardiovascular risk factors (CVRF.Data were derived from the cross sectional NESCAV (Nutrition, Environment and Cardiovascular Health study, aiming to describe the cardiovascular health of the Greater region's population (Grand duchy of Luxembourg, Wallonia (Belgium, Lorraine (France. 2298 individuals were included for this study and dietary intake was assessed using a 134-item food frequency questionnaire.We found that CVRF-related patterns also reflect eating behaviours of the population. Comparing concordant food groups between both dietary pattern methods, a diet high in fruits, oleaginous and dried fruits, vegetables, olive oil, fats rich in omega 6 and tea and low in fried foods, lean and fatty meat, processed meat, ready meal, soft drink and beer was associated with lower prevalence of CVRF. In the opposite, a pattern characterized by high intakes of fried foods, meat, offal, beer, wine and aperitifs and spirits, and low intakes of cereals, sugar and sweets and soft drinks was associated with higher prevalence of CVRF.In sum, we found that a "Prudent" and "Animal protein and alcohol" patterns were both associated with CVRF and behaviourally meaningful. Moreover, the relationships of those dietary patterns with lifestyle characteristics support the theory that food choices are part of a larger pattern of healthy lifestyle.

  13. Magnetostatic fields computed using an integral equation derived from Green's theorems

    International Nuclear Information System (INIS)

    Simkin, J.; Trowbridge, C.W.

    1976-04-01

    A method of computing magnetostatic fields is described that is based on a numerical solution of the integral equation obtained from Green's Theorems. The magnetic scalar potential and its normal derivative on the surfaces of volumes are found by solving a set of linear equations. These are obtained from Green's Second Theorem and the continuity conditions at interfaces between volumes. Results from a two-dimensional computer program are presented and these show the method to be accurate and efficient. (author)

  14. Canonical path integral measures for Holst and Plebanski gravity: I. Reduced phase space derivation

    International Nuclear Information System (INIS)

    Engle, Jonathan; Han Muxin; Thiemann, Thomas

    2010-01-01

    An important aspect in defining a path integral quantum theory is the determination of the correct measure. For interacting theories and theories with constraints, this is non-trivial, and is normally not the heuristic 'Lebesgue measure' usually used. There have been many determinations of a measure for gravity in the literature, but none for the Palatini or Holst formulations of gravity. Furthermore, the relations between different resulting measures for different formulations of gravity are usually not discussed. In this paper we use the reduced phase technique in order to derive the path-integral measure for the Palatini and Holst formulation of gravity, which is different from the Lebesgue measure up to local measure factors which depend on the spacetime volume element and spatial volume element. From this path integral for the Holst formulation of general relativity we can also give a new derivation of the Plebanski path integral and discover a discrepancy with the result due to Buffenoir, Henneaux, Noui and Roche whose origin we resolve. This paper is the first in a series that aims at better understanding the relation between canonical loop quantum gravity and the spin-foam approach.

  15. Empirical Philosophy of Science

    DEFF Research Database (Denmark)

    Mansnerus, Erika; Wagenknecht, Susann

    2015-01-01

    knowledge takes place through the integration of the empirical or historical research into the philosophical studies, as Chang, Nersessian, Thagard and Schickore argue in their work. Building upon their contributions we will develop a blueprint for an Empirical Philosophy of Science that draws upon...... qualitative methods from the social sciences in order to advance our philosophical understanding of science in practice. We will regard the relationship between philosophical conceptualization and empirical data as an iterative dialogue between theory and data, which is guided by a particular ‘feeling with......Empirical insights are proven fruitful for the advancement of Philosophy of Science, but the integration of philosophical concepts and empirical data poses considerable methodological challenges. Debates in Integrated History and Philosophy of Science suggest that the advancement of philosophical...

  16. Patient-Specific Seizure Detection in Long-Term EEG Using Signal-Derived Empirical Mode Decomposition (EMD)-based Dictionary Approach.

    Science.gov (United States)

    Kaleem, Muhammad; Gurve, Dharmendra; Guergachi, Aziz; Krishnan, Sridhar

    2018-06-25

    The objective of the work described in this paper is development of a computationally efficient methodology for patient-specific automatic seizure detection in long-term multi-channel EEG recordings. Approach: A novel patient-specific seizure detection approach based on signal-derived Empirical Mode Decomposition (EMD)-based dictionary approach is proposed. For this purpose, we use an empirical framework for EMD-based dictionary creation and learning, inspired by traditional dictionary learning methods, in which the EMD-based dictionary is learned from the multi-channel EEG data being analyzed for automatic seizure detection. We present the algorithm for dictionary creation and learning, whose purpose is to learn dictionaries with a small number of atoms. Using training signals belonging to seizure and non-seizure classes, an initial dictionary, termed as the raw dictionary, is formed. The atoms of the raw dictionary are composed of intrinsic mode functions obtained after decomposition of the training signals using the empirical mode decomposition algorithm. The raw dictionary is then trained using a learning algorithm, resulting in a substantial decrease in the number of atoms in the trained dictionary. The trained dictionary is then used for automatic seizure detection, such that coefficients of orthogonal projections of test signals against the trained dictionary form the features used for classification of test signals into seizure and non-seizure classes. Thus no hand-engineered features have to be extracted from the data as in traditional seizure detection approaches. Main results: The performance of the proposed approach is validated using the CHB-MIT benchmark database, and averaged accuracy, sensitivity and specificity values of 92.9%, 94.3% and 91.5%, respectively, are obtained using support vector machine classifier and five-fold cross-validation method. These results are compared with other approaches using the same database, and the suitability

  17. Solar-wind predictions for the Parker Solar Probe orbit. Near-Sun extrapolations derived from an empirical solar-wind model based on Helios and OMNI observations

    Science.gov (United States)

    Venzmer, M. S.; Bothmer, V.

    2018-03-01

    Context. The Parker Solar Probe (PSP; formerly Solar Probe Plus) mission will be humanitys first in situ exploration of the solar corona with closest perihelia at 9.86 solar radii (R⊙) distance to the Sun. It will help answer hitherto unresolved questions on the heating of the solar corona and the source and acceleration of the solar wind and solar energetic particles. The scope of this study is to model the solar-wind environment for PSPs unprecedented distances in its prime mission phase during the years 2018 to 2025. The study is performed within the Coronagraphic German And US SolarProbePlus Survey (CGAUSS) which is the German contribution to the PSP mission as part of the Wide-field Imager for Solar PRobe. Aim. We present an empirical solar-wind model for the inner heliosphere which is derived from OMNI and Helios data. The German-US space probes Helios 1 and Helios 2 flew in the 1970s and observed solar wind in the ecliptic within heliocentric distances of 0.29 au to 0.98 au. The OMNI database consists of multi-spacecraft intercalibrated in situ data obtained near 1 au over more than five solar cycles. The international sunspot number (SSN) and its predictions are used to derive dependencies of the major solar-wind parameters on solar activity and to forecast their properties for the PSP mission. Methods: The frequency distributions for the solar-wind key parameters, magnetic field strength, proton velocity, density, and temperature, are represented by lognormal functions. In addition, we consider the velocity distributions bi-componental shape, consisting of a slower and a faster part. Functional relations to solar activity are compiled with use of the OMNI data by correlating and fitting the frequency distributions with the SSN. Further, based on the combined data set from both Helios probes, the parameters frequency distributions are fitted with respect to solar distance to obtain power law dependencies. Thus an empirical solar-wind model for the inner

  18. GM-CSF ameliorates microvascular barrier integrity via pericyte-derived Ang-1 in wound healing.

    Science.gov (United States)

    Yan, Min; Hu, Yange; Yao, Min; Bao, Shisan; Fang, Yong

    2017-11-01

    Skin wound healing involves complex coordinated interactions of cells, tissues, and mediators. Maintaining microvascular barrier integrity is one of the key events for endothelial homeostasis during wound healing. Vasodilation is observed after vasoconstriction, which causes blood vessels to become porous, facilitates leukocyte infiltration and aids angiogenesis at the wound-area, postinjury. Eventually, vessel integrity has to be reestablished for vascular maturation. Numerous studies have found that granulocyte macrophage colony-stimulating factor (GM-CSF) accelerates wound healing by inducing recruitment of repair cells into the injury area and releases of cytokines. However, whether GM-CSF is involving in the maintaining of microvascular barrier integrity and the underlying mechanism remain still unclear. Aim of this study was to investigate the effects of GM-CSF on modulation of microvascular permeability in wound healing and underlying mechanisms. Wound closure and microvascular leakage was investigated using a full-thickness skin wound mouse model after GM-CSF intervention. The endothelial permeability was measured by Evans blue assay in vivo and in vitro endothelium/pericyte co-culture system using a FITC-Dextran permeability assay. To identify the source of angiopoietin-1 (Ang-1), double staining is used in vivo and ELISA and qPCR are used in vitro. To determine the specific effect of Ang-1 on GM-CSF maintaining microvascular stabilization, Ang-1 siRNA was applied to inhibit Ang-1 production in vivo and in vitro. Wound closure was significantly accelerated and microvascular leakage was ameliorated after GM-CSF treatment in mouse wound sites. GM-CSF decreased endothelial permeability through tightening endothelial junctions and increased Ang-1 protein level that was derived by perictye. Furthermore, applications of siRNAAng-1 inhibited GM-CSF mediated protection of microvascular barrier integrity both in vivo and in vitro. Our data indicate that GM

  19. Empirically Derived Dehydration Scoring and Decision Tree Models for Children With Diarrhea: Assessment and Internal Validation in a Prospective Cohort Study in Dhaka, Bangladesh.

    Science.gov (United States)

    Levine, Adam C; Glavis-Bloom, Justin; Modi, Payal; Nasrin, Sabiha; Rege, Soham; Chu, Chieh; Schmid, Christopher H; Alam, Nur H

    2015-08-18

    Diarrhea remains one of the most common and most deadly conditions affecting children worldwide. Accurately assessing dehydration status is critical to determining treatment course, yet no clinical diagnostic models for dehydration have been empirically derived and validated for use in resource-limited settings. In the Dehydration: Assessing Kids Accurately (DHAKA) prospective cohort study, a random sample of children under 5 with acute diarrhea was enrolled between February and June 2014 in Bangladesh. Local nurses assessed children for clinical signs of dehydration on arrival, and then serial weights were obtained as subjects were rehydrated. For each child, the percent weight change with rehydration was used to classify subjects with severe dehydration (>9% weight change), some dehydration (3-9%), or no dehydration (Dehydration Score and DHAKA Dehydration Tree, respectively. Models were assessed for their accuracy using the area under their receiver operating characteristic curve (AUC) and for their reliability through repeat clinical exams. Bootstrapping was used to internally validate the models. A total of 850 children were enrolled, with 771 included in the final analysis. Of the 771 children included in the analysis, 11% were classified with severe dehydration, 45% with some dehydration, and 44% with no dehydration. Both the DHAKA Dehydration Score and DHAKA Dehydration Tree had significant AUCs of 0.79 (95% CI = 0.74, 0.84) and 0.76 (95% CI = 0.71, 0.80), respectively, for the diagnosis of severe dehydration. Additionally, the DHAKA Dehydration Score and DHAKA Dehydration Tree had significant positive likelihood ratios of 2.0 (95% CI = 1.8, 2.3) and 2.5 (95% CI = 2.1, 2.8), respectively, and significant negative likelihood ratios of 0.23 (95% CI = 0.13, 0.40) and 0.28 (95% CI = 0.18, 0.44), respectively, for the diagnosis of severe dehydration. Both models demonstrated 90% agreement between independent raters and good

  20. The derivation of vector magnetic fields from Stokes profiles - Integral versus least squares fitting techniques

    Science.gov (United States)

    Ronan, R. S.; Mickey, D. L.; Orrall, F. Q.

    1987-01-01

    The results of two methods for deriving photospheric vector magnetic fields from the Zeeman effect, as observed in the Fe I line at 6302.5 A at high spectral resolution (45 mA), are compared. The first method does not take magnetooptical effects into account, but determines the vector magnetic field from the integral properties of the Stokes profiles. The second method is an iterative least-squares fitting technique which fits the observed Stokes profiles to the profiles predicted by the Unno-Rachkovsky solution to the radiative transfer equation. For sunspot fields above about 1500 gauss, the two methods are found to agree in derived azimuthal and inclination angles to within about + or - 20 deg.

  1. BioPepDB: an integrated data platform for food-derived bioactive peptides.

    Science.gov (United States)

    Li, Qilin; Zhang, Chao; Chen, Hongjun; Xue, Jitong; Guo, Xiaolei; Liang, Ming; Chen, Ming

    2018-03-12

    Food-derived bioactive peptides play critical roles in regulating most biological processes and have considerable biological, medical and industrial importance. However, a large number of active peptides data, including sequence, function, source, commercial product information, references and other information are poorly integrated. BioPepDB is a searchable database of food-derived bioactive peptides and their related articles, including more than four thousand bioactive peptide entries. Moreover, BioPepDB provides modules of prediction and hydrolysis-simulation for discovering novel peptides. It can serve as a reference database to investigate the function of different bioactive peptides. BioPepDB is available at http://bis.zju.edu.cn/biopepdbr/ . The web page utilises Apache, PHP5 and MySQL to provide the user interface for accessing the database and predict novel peptides. The database itself is operated on a specialised server.

  2. Integrated synthesis of poly(o-phenylenediamine)-derived carbon materials for high performance supercapacitors

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Hui; Wang, Xiaolei; Liu, Xuexia; Yang, Xiurong [State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (China)

    2012-12-18

    Poly(o-phenylenediamine) (POPD)-derived functional carbon materials with excellent capacitive performance are successfully synthesized by means of an integrated one-step process, in which FeCl{sub 3} not only oxidizes the polymerization of the organic monomers but also activates the carbonization. Furthermore, extensive research has proved that this strategy to discover novel carbons is useful not only for capacitors but also for other energy storage/conversion devices. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  3. Integrated synthesis of poly(o-phenylenediamine)-derived carbon materials for high performance supercapacitors.

    Science.gov (United States)

    Zhu, Hui; Wang, Xiaolei; Liu, Xuexia; Yang, Xiurong

    2012-12-18

    Poly(o-phenylenediamine) (POPD)-derived functional carbon materials with excellent capacitive performance are successfully synthesized by means of an integrated one-step process, in which FeCl(3) not only oxidizes the polymerization of the organic monomers but also activates the carbonization. Furthermore, extensive research has proved that this strategy to discover novel carbons is useful not only for capacitors but also for other energy storage/conversion devices. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Asymptotic integration of some nonlinear differential equations with fractional time derivative

    International Nuclear Information System (INIS)

    Baleanu, Dumitru; Agarwal, Ravi P; Mustafa, Octavian G; Cosulschi, Mirel

    2011-01-01

    We establish that, under some simple integral conditions regarding the nonlinearity, the (1 + α)-order fractional differential equation 0 D α t (x') + f(t, x) = 0, t > 0, has a solution x element of C([0,+∞),R) intersection C 1 ((0,+∞),R), with lim t→0 [t 1-α x'(t)] element of R, which can be expanded asymptotically as a + bt α + O(t α-1 ) when t → +∞ for given real numbers a, b. Our arguments are based on fixed point theory. Here, 0 D α t designates the Riemann-Liouville derivative of order α in (0, 1).

  5. Wireless passive polymer-derived SiCN ceramic sensor with integrated resonator/antenna

    Science.gov (United States)

    Li, Yan; Yu, Yuxi; San, Haisheng; Wang, Yansong; An, Linan

    2013-10-01

    This paper presents a passive wireless polymer-derived silicon carbonitride (SiCN) ceramic sensor based on cavity radio frequency resonator together with integrated slot antenna. The effect of the cavity sensor dimensions on the Q-factor and resonant frequency is investigated by numerical simulation. A sensor with optimal dimensions is designed and fabricated. It is demonstrated that the sensor signal can be wirelessly detected at distances up to 20 mm. Given the high-temperature stability of the SiCN, the sensor is very promising for high-temperature wireless sensing applications.

  6. Empirically derived dietary patterns and incident type 2 diabetes mellitus: a systematic review and meta-analysis on prospective observational studies.

    Science.gov (United States)

    Maghsoudi, Zahra; Ghiasvand, Reza; Salehi-Abargouei, Amin

    2016-02-01

    To systematically review prospective cohort studies about the association between dietary patterns and type 2 diabetes mellitus (T2DM) incidence, and to quantify the effects using a meta-analysis. Databases such as PubMed, ISI Web of Science, SCOPUS and Google Scholar were searched up to 15 January 2015. Cohort studies which tried to examine the association between empirically derived dietary patterns and incident T2DM were selected. The relative risks (RR) and their 95 % confidence intervals for diabetes among participants with highest v. lowest adherence to derived dietary patterns were incorporated into meta-analysis using random-effects models. Ten studies (n 404 528) were enrolled in the systematic review and meta-analysis; our analysis revealed that adherence to the 'healthy' dietary patterns significantly reduced the risk of T2DM (RR=0·86; 95 % CI 0·82, 0·90), while the 'unhealthy' dietary patterns adversely affected diabetes risk (RR=1·30; 95 % CI 1·18, 1·43). Subgroup analysis showed that unhealthy dietary patterns in which foods with high phytochemical content were also loaded did not significantly increase T2DM risk (RR=1·06; 95 % CI 0·87, 1·30). 'Healthy' dietary patterns containing vegetables, fruits and whole grains can lower diabetes risk by 14 %. Consuming higher amounts of red and processed meats, high-fat dairy and refined grains in the context of 'unhealthy' dietary patterns will increase diabetes risk by 30 %; while including foods with high phytochemical content in these patterns can modify this effect.

  7. CHARACTERIZING THE HEAVY ELEMENTS IN GLOBULAR CLUSTER M22 AND AN EMPIRICAL s-PROCESS ABUNDANCE DISTRIBUTION DERIVED FROM THE TWO STELLAR GROUPS

    International Nuclear Information System (INIS)

    Roederer, I. U.; Marino, A. F.; Sneden, C.

    2011-01-01

    We present an empirical s-process abundance distribution derived with explicit knowledge of the r-process component in the low-metallicity globular cluster M22. We have obtained high-resolution, high signal-to-noise spectra for six red giants in M22 using the Magellan Inamori Kyocera Echelle spectrograph on the Magellan-Clay Telescope at Las Campanas Observatory. In each star we derive abundances for 44 species of 40 elements, including 24 elements heavier than zinc (Z = 30) produced by neutron-capture reactions. Previous studies determined that three of these stars (the 'r+s group') have an enhancement of s-process material relative to the other three stars (the 'r-only group'). We confirm that the r+s group is moderately enriched in Pb relative to the r-only group. Both groups of stars were born with the same amount of r-process material, but s-process material was also present in the gas from which the r+s group formed. The s-process abundances are inconsistent with predictions for asymptotic giant branch (AGB) stars with M ≤ 3 M ☉ and suggest an origin in more massive AGB stars capable of activating the 22 Ne(α,n) 25 Mg reaction. We calculate the s-process 'residual' by subtracting the r-process pattern in the r-only group from the abundances in the r+s group. In contrast to previous r- and s-process decompositions, this approach makes no assumptions about the r- and s-process distributions in the solar system and provides a unique opportunity to explore s-process yields in a metal-poor environment.

  8. Characterizing the Heavy Elements in Globular Cluster M22 and an Empirical s-process Abundance Distribution Derived from the Two Stellar Groups

    Science.gov (United States)

    Roederer, I. U.; Marino, A. F.; Sneden, C.

    2011-11-01

    We present an empirical s-process abundance distribution derived with explicit knowledge of the r-process component in the low-metallicity globular cluster M22. We have obtained high-resolution, high signal-to-noise spectra for six red giants in M22 using the Magellan Inamori Kyocera Echelle spectrograph on the Magellan-Clay Telescope at Las Campanas Observatory. In each star we derive abundances for 44 species of 40 elements, including 24 elements heavier than zinc (Z = 30) produced by neutron-capture reactions. Previous studies determined that three of these stars (the "r+s group") have an enhancement of s-process material relative to the other three stars (the "r-only group"). We confirm that the r+s group is moderately enriched in Pb relative to the r-only group. Both groups of stars were born with the same amount of r-process material, but s-process material was also present in the gas from which the r+s group formed. The s-process abundances are inconsistent with predictions for asymptotic giant branch (AGB) stars with M <= 3 M ⊙ and suggest an origin in more massive AGB stars capable of activating the 22Ne(α,n)25Mg reaction. We calculate the s-process "residual" by subtracting the r-process pattern in the r-only group from the abundances in the r+s group. In contrast to previous r- and s-process decompositions, this approach makes no assumptions about the r- and s-process distributions in the solar system and provides a unique opportunity to explore s-process yields in a metal-poor environment. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.

  9. Integrated Foreign Exchange Risk Management

    DEFF Research Database (Denmark)

    Aabo, Tom; Høg, Esben; Kuhn, Jochen

    Empirical research has focused on export as a proxy for the exchange rate exposure and the use of foreign exchange derivatives as the instrument to deal with this exposure. This empirical study applies an integrated foreign exchange risk management approach with a particular focus on the role...

  10. Human neural progenitors derived from integration-free iPSCs for SCI therapy

    Directory of Open Access Journals (Sweden)

    Ying Liu

    2017-03-01

    Full Text Available As a potentially unlimited autologous cell source, patient induced pluripotent stem cells (iPSCs provide great capability for tissue regeneration, particularly in spinal cord injury (SCI. However, despite significant progress made in translation of iPSC-derived neural progenitor cells (NPCs to clinical settings, a few hurdles remain. Among them, non-invasive approach to obtain source cells in a timely manner, safer integration-free delivery of reprogramming factors, and purification of NPCs before transplantation are top priorities to overcome. In this study, we developed a safe and cost-effective pipeline to generate clinically relevant NPCs. We first isolated cells from patients' urine and reprogrammed them into iPSCs by non-integrating Sendai viral vectors, and carried out experiments on neural differentiation. NPCs were purified by A2B5, an antibody specifically recognizing a glycoganglioside on the cell surface of neural lineage cells, via fluorescence activated cell sorting. Upon further in vitro induction, NPCs were able to give rise to neurons, oligodendrocytes and astrocytes. To test the functionality of the A2B5+ NPCs, we grafted them into the contused mouse thoracic spinal cord. Eight weeks after transplantation, the grafted cells survived, integrated into the injured spinal cord, and differentiated into neurons and glia. Our specific focus on cell source, reprogramming, differentiation and purification method purposely addresses timing and safety issues of transplantation to SCI models. It is our belief that this work takes one step closer on using human iPSC derivatives to SCI clinical settings.

  11. Derivation of the Schrodinger Equation from the Hamilton-Jacobi Equation in Feynman's Path Integral Formulation of Quantum Mechanics

    Science.gov (United States)

    Field, J. H.

    2011-01-01

    It is shown how the time-dependent Schrodinger equation may be simply derived from the dynamical postulate of Feynman's path integral formulation of quantum mechanics and the Hamilton-Jacobi equation of classical mechanics. Schrodinger's own published derivations of quantum wave equations, the first of which was also based on the Hamilton-Jacobi…

  12. The effect of loss functions on empirical Bayes reliability analysis

    Directory of Open Access Journals (Sweden)

    Vincent A. R. Camara

    1999-01-01

    Full Text Available The aim of the present study is to investigate the sensitivity of empirical Bayes estimates of the reliability function with respect to changing of the loss function. In addition to applying some of the basic analytical results on empirical Bayes reliability obtained with the use of the “popular” squared error loss function, we shall derive some expressions corresponding to empirical Bayes reliability estimates obtained with the Higgins–Tsokos, the Harris and our proposed logarithmic loss functions. The concept of efficiency, along with the notion of integrated mean square error, will be used as a criterion to numerically compare our results.

  13. An empirical study to measure the impact of e-business on organizational performance with an emphasis on integrated production information

    Directory of Open Access Journals (Sweden)

    Hadi Meftahi

    2012-08-01

    Full Text Available During the past few decades, there have been different studies on e-business but there are limited numbers of works accomplished on measuring the impact of e-business on supply chain. Although e-business may not directly influence on organizational performance, it can have significant indirect impact on unifying customers and suppliers, which yields to a better performance of organizations. In this study, we perform an empirical study to measure the indirect impact of e-business on organizational performance. The proposed study of this paper designs a questionnaire and distributes it among 40 professional experts in various industries in province of Ilam, Iran. The survey examines four hypothesis for a possible correlation between e-business and integrated suppliers, e-business and customers, integrated customers and suppliers with organizational performance. The results of this survey confirm a positive relationship between all these components either directly or indirectly.

  14. Integrated ozonation and biomethanization treatments of vinasse derived from ethanol manufacturing

    International Nuclear Information System (INIS)

    Siles, J.A.; Garcia-Garcia, I.; Martin, A.; Martin, M.A.

    2011-01-01

    Anaerobic digestion of vinasse derived from bioethanol manufacturing, in which total COD was found to be 68.56 ± 8.17 g/L, was studied in batch laboratory-scale reactors at mesophilic temperature (35 deg. C). The vinasse was subjected to a short ozonation pre-treatment (15 min) in which more than 50% reduction of phenols was observed, although the total organic carbon concentration remained approximately stable, indicating that the phenols were transformed into other simpler forms. The anaerobic biodegradability of raw and pre-treated vinasse was similar, reaching values close to 80% (COD). However, the methane yield coefficient and methane production rate enhanced by around 13.6% and 41.16%, respectively, when the ozonized vinasse was fed. These results indicate that the integration of chemical-biological treatments could be a viable option for the purification of this hazardous wastewater.

  15. Digital proportional-integral-derivative velocity controller of a Mössbauer spectrometer

    International Nuclear Information System (INIS)

    Pechousek, J; Prochazka, R; Mashlan, M; Jancik, D; Frydrych, J

    2009-01-01

    The digital proportional-integral-derivative (PID) velocity controller used in the Mössbauer spectrometer implemented in field programmable gate array (FPGA) is based on the National Instruments CompactRIO embedded system and LabVIEW graphical programming tools. The system works as a remote system accessible via the Ethernet. The digital controller operates in real-time conditions, and the maximum sampling frequency is approximately 227 kS s −1 . The system was tested with standard sample measurements of α-Fe and α- 57 Fe 2 O 3 on two different electromechanical velocity transducers. The nonlinearities of the velocity scales in the relative form are better than 0.2%. The replacement of the standard analog PID controller by the new system brings the possibility of optimizing the control process more precisely. (technical design note)

  16. TECHNICAL DESIGN NOTE: Digital proportional-integral-derivative velocity controller of a Mössbauer spectrometer

    Science.gov (United States)

    Pechousek, J.; Prochazka, R.; Mashlan, M.; Jancik, D.; Frydrych, J.

    2009-01-01

    The digital proportional-integral-derivative (PID) velocity controller used in the Mössbauer spectrometer implemented in field programmable gate array (FPGA) is based on the National Instruments CompactRIO embedded system and LabVIEW graphical programming tools. The system works as a remote system accessible via the Ethernet. The digital controller operates in real-time conditions, and the maximum sampling frequency is approximately 227 kS s-1. The system was tested with standard sample measurements of α-Fe and α-57Fe2O3 on two different electromechanical velocity transducers. The nonlinearities of the velocity scales in the relative form are better than 0.2%. The replacement of the standard analog PID controller by the new system brings the possibility of optimizing the control process more precisely.

  17. NOAA Integrated Ocean and Coastal Mapping (IOCM) orthorectified mosaic image tiles, Empire, Louisiana 2010 (NODC Accession 0075830)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains ortho-rectified mosaic tiles, created as a product from the NOAA Integrated Ocean and Coastal Mapping (IOCM) initiative of the Mississippi -...

  18. Cell kinetics, DNA integrity, differentiation, and lipid fingerprinting analysis of rabbit adipose-derived stem cells.

    Science.gov (United States)

    Barretto, Letícia Siqueira de Sá; Lessio, Camila; Sawaki e Nakamura, Ahy Natally; Lo Turco, Edson Guimarães; da Silva, Camila Gonzaga; Zambon, João Paulo; Gozzo, Fábio César; Pilau, Eduardo Jorge; de Almeida, Fernando Gonçalves

    2014-10-01

    Human adipose tissue has been described as a potential alternative reservoir for stem cells. Although studies have been performed in rabbits using autologous adipose-derived stem cells (ADSC), these cells have not been well characterized. The primary objectives of this study were to demonstrate the presence of adipose-derived stem cells isolated from rabbit inguinal fat pads and to characterize them through osteogenic and adipogenic in vitro differentiation and lipid fingerprinting analysis. The secondary objective was to evaluate cell behavior through growth kinetics, cell viability, and DNA integrity. Rabbit ADSCs were isolated to determine the in vitro growth kinetics and cell viability. DNA integrity was assessed by an alkaline Comet assay in passages 0 and 5. The osteogenic differentiation was evaluated by Von Kossa, and Alizarin Red S staining and adipogenic differentiation were assessed by Oil Red O staining. Lipid fingerprinting analyses of control, adipogenic, and osteogenic differentiated cells were performed by MALDI-TOF/MS. We demonstrate that rabbit ADSC have a constant growth rate at the early passages, with increased DNA fragmentation at or after passage 5. Rabbit ADSC viability was similar in passages 2 and 5 (90.7% and 86.6%, respectively), but there was a tendency to decreased cellular growth rate after passage 3. The ADSC were characterized by the expression of surface markers such as CD29 (67.4%) and CD44 (89.4%), using CD 45 (0.77%) as a negative control. ADSC from rabbits were successfully isolated form the inguinal region. These cells were capable to differentiate into osteogenic and adipogenic tissue when they were placed in inductive media. After each passage, there was a trend towards decreased cell growth. On the other hand, DNA fragmentation increased at each passage. ADSC had a different lipid profile when placed in control, adipogenic, or osteogenic media.

  19. Semi-empirical γ-ray peak efficiency determination including self-absorption correction based on numerical integration

    International Nuclear Information System (INIS)

    Noguchi, M.; Takeda, K.; Higuchi, H.

    1981-01-01

    A method of γ-ray efficiency determination for extended (plane or bulk) samples based on numerical integration of point source efficiency is studied. The proposed method is widely applicable to samples of various shapes and materials. The geometrical factor in the peak efficiency can easily be corrected for by simply changing the integration region, and γ-ray self-absorption is also corrected by the absorption coefficients for the sample matrix. (author)

  20. Determination of zenith hydrostatic delay and its impact on GNSS-derived integrated water vapor

    Directory of Open Access Journals (Sweden)

    X. Wang

    2017-08-01

    Full Text Available Surface pressure is a necessary meteorological variable for the accurate determination of integrated water vapor (IWV using Global Navigation Satellite System (GNSS. The lack of pressure observations is a big issue for the conversion of historical GNSS observations, which is a relatively new area of GNSS applications in climatology. Hence the use of the surface pressure derived from either a blind model (e.g., Global Pressure and Temperature 2 wet, GPT2w or a global atmospheric reanalysis (e.g., ERA-Interim becomes an important alternative solution. In this study, pressure derived from these two methods is compared against the pressure observed at 108 global GNSS stations at four epochs (00:00, 06:00, 12:00 and 18:00 UTC each day for the period 2000–2013. Results show that a good accuracy is achieved from the GPT2w-derived pressure in the latitude band between −30 and 30° and the average value of 6 h root-mean-square errors (RMSEs across all the stations in this region is 2.5 hPa. Correspondingly, an error of 5.8 mm and 0.9 kg m−2 in its resultant zenith hydrostatic delay (ZHD and IWV is expected. However, for the stations located in the mid-latitude bands between −30 and −60° and between 30 and 60°, the mean value of the RMSEs is 7.3 hPa, and for the stations located in the high-latitude bands from −60 to −90° and from 60 to 90°, the mean value of the RMSEs is 9.9 hPa. The mean of the RMSEs of the ERA-Interim-derived pressure across at the selected 100 stations is 0.9 hPa, which will lead to an equivalent error of 2.1 mm and 0.3 kg m−2 in the ZHD and IWV, respectively, determined from this ERA-Interim-derived pressure. Results also show that the monthly IWV determined using pressure from ERA-Interim has a good accuracy − with a relative error of better than 3 % on a global scale; thus, the monthly IWV resulting from ERA-Interim-derived pressure has the potential to be used for climate studies

  1. Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs.

    Science.gov (United States)

    Liu, Guang-Hui; Suzuki, Keiichiro; Li, Mo; Qu, Jing; Montserrat, Nuria; Tarantino, Carolina; Gu, Ying; Yi, Fei; Xu, Xiuling; Zhang, Weiqi; Ruiz, Sergio; Plongthongkum, Nongluk; Zhang, Kun; Masuda, Shigeo; Nivet, Emmanuel; Tsunekawa, Yuji; Soligalla, Rupa Devi; Goebl, April; Aizawa, Emi; Kim, Na Young; Kim, Jessica; Dubova, Ilir; Li, Ying; Ren, Ruotong; Benner, Chris; Del Sol, Antonio; Bueren, Juan; Trujillo, Juan Pablo; Surralles, Jordi; Cappelli, Enrico; Dufour, Carlo; Esteban, Concepcion Rodriguez; Belmonte, Juan Carlos Izpisua

    2014-07-07

    Fanconi anaemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the pathogenesis of FA is not fully understood partly due to the limitations of current disease models. Here, we derive integration free-induced pluripotent stem cells (iPSCs) from an FA patient without genetic complementation and report in situ gene correction in FA-iPSCs as well as the generation of isogenic FANCA-deficient human embryonic stem cell (ESC) lines. FA cellular phenotypes are recapitulated in iPSCs/ESCs and their adult stem/progenitor cell derivatives. By using isogenic pathogenic mutation-free controls as well as cellular and genomic tools, our model serves to facilitate the discovery of novel disease features. We validate our model as a drug-screening platform by identifying several compounds that improve hematopoietic differentiation of FA-iPSCs. These compounds are also able to rescue the hematopoietic phenotype of FA patient BM cells.

  2. Modeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs

    Science.gov (United States)

    Montserrat, Nuria; Tarantino, Carolina; Gu, Ying; Yi, Fei; Xu, Xiuling; Zhang, Weiqi; Ruiz, Sergio; Plongthongkum, Nongluk; Zhang, Kun; Masuda, Shigeo; Nivet, Emmanuel; Tsunekawa, Yuji; Soligalla, Rupa Devi; Goebl, April; Aizawa, Emi; Kim, Na Young; Kim, Jessica; Dubova, Ilir; Li, Ying; Ren, Ruotong; Benner, Chris; del Sol, Antonio; Bueren, Juan; Trujillo, Juan Pablo; Surralles, Jordi; Cappelli, Enrico; Dufour, Carlo; Esteban, Concepcion Rodriguez; Belmonte, Juan Carlos Izpisua

    2014-01-01

    Fanconi Anemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow failure. However, the pathogenesis of FA is not fully understood partly due to the limitations of current disease models. Here, we derive integration-free induced pluripotent stem cells (iPSCs) from an FA patient without genetic complementation and report in situ gene correction in FA-iPSCs as well as the generation of isogenic FANCA deficient human embryonic stem cell (ESC) lines. FA cellular phenotypes are recapitulated in iPSCs/ESCs and their adult stem/progenitor cell derivatives. By using isogenic pathogenic mutation-free controls as well as cellular and genomic tools, our model serves to facilitate the discovery of novel disease features. We validate our model as a drug-screening platform by identifying several compounds that improve hematopoietic differentiation of FA-iPSCs. These compounds are also able to rescue the hematopoietic phenotype of FA-patient bone marrow cells. PMID:24999918

  3. CONSIDERATIONS FOR THE MASS AND ENERGY INTEGRATION IN THE SUGAR PROCESS PRODUCTION AND DERIVATIVE PROCESS

    Directory of Open Access Journals (Sweden)

    Dennis Abel Clavelo Sierra

    2015-04-01

    Full Text Available The current society needs now more than ever of industries that create new forms and methods where the saving of energy and materials is a fundamental aspect. For this reason, in the present investigation we present an outline with the considerations for the integration of the processes of sugar and other derived products, in an outline of bio refinery with the objective of achieving efficient processes with an appropriate use of the material resources and an efficient use of the energy, with minimum operation costs and investment. In the outline we take as base for the study, it is considered that the integrated complex has as basic input the sugarcane; it is also considered the variation of the prices of the products in the market. In the article we make an outline with the precise steps for the development of a methodology that allows analyzing the processes involved in the biorefinery outline and in this way to identify the common material and energy resources that the processes exchange. A heuristic diagram is presented that guides the strategy to continue for it.

  4. Digitally controlled analog proportional-integral-derivative (PID) controller for high-speed scanning probe microscopy

    Science.gov (United States)

    Dukic, Maja; Todorov, Vencislav; Andany, Santiago; Nievergelt, Adrian P.; Yang, Chen; Hosseini, Nahid; Fantner, Georg E.

    2017-12-01

    Nearly all scanning probe microscopes (SPMs) contain a feedback controller, which is used to move the scanner in the direction of the z-axis in order to maintain a constant setpoint based on the tip-sample interaction. The most frequently used feedback controller in SPMs is the proportional-integral (PI) controller. The bandwidth of the PI controller presents one of the speed limiting factors in high-speed SPMs, where higher bandwidths enable faster scanning speeds and higher imaging resolution. Most SPM systems use digital signal processor-based PI feedback controllers, which require analog-to-digital and digital-to-analog converters. These converters introduce additional feedback delays which limit the achievable imaging speed and resolution. In this paper, we present a digitally controlled analog proportional-integral-derivative (PID) controller. The controller implementation allows tunability of the PID gains over a large amplification and frequency range, while also providing precise control of the system and reproducibility of the gain parameters. By using the analog PID controller, we were able to perform successful atomic force microscopy imaging of a standard silicon calibration grating at line rates up to several kHz.

  5. Requirement Volatility, Standardization and Knowledge Integration in Software Projects: An Empirical Analysis on Outsourced IS Development Projects

    Directory of Open Access Journals (Sweden)

    Rajesri Govindaraju

    2015-08-01

    Full Text Available Information systems development (ISD projects are highly complex, with different groups of people having  to collaborate and exchange their knowledge. Considering the intensity of knowledge exchange that takes place in outsourced ISD projects, in this study a conceptual model was developed, aiming to examine the influence of four antecedents, i.e. standardization, requirement volatility, internal integration, and external integration, on two dependent variables, i.e. process performance and product performance. Data  were collected from 46 software companies in four big cities in Indonesia. The collected data were examined to verify the proposed theoretical model using the partial least square structural equation modeling (PLS-SEM technique. The results show that process performance is significantly influenced by internal integration and standardization, while product performance is  significantly influenced by external integration and  requirement volatility. This study contributes  to a better understanding of how knowledge integration can be managed in outsourced ISD projects in view of increasing their success.

  6. The effect of loss functions on empirical Bayes reliability analysis

    Directory of Open Access Journals (Sweden)

    Camara Vincent A. R.

    1998-01-01

    Full Text Available The aim of the present study is to investigate the sensitivity of empirical Bayes estimates of the reliability function with respect to changing of the loss function. In addition to applying some of the basic analytical results on empirical Bayes reliability obtained with the use of the “popular” squared error loss function, we shall derive some expressions corresponding to empirical Bayes reliability estimates obtained with the Higgins–Tsokos, the Harris and our proposed logarithmic loss functions. The concept of efficiency, along with the notion of integrated mean square error, will be used as a criterion to numerically compare our results. It is shown that empirical Bayes reliability functions are in general sensitive to the choice of the loss function, and that the squared error loss does not always yield the best empirical Bayes reliability estimate.

  7. Inglorious Empire

    DEFF Research Database (Denmark)

    Khair, Tabish

    2017-01-01

    Review of 'Inglorious Empire: What the British did to India' by Shashi Tharoor, London, Hurst Publishers, 2017, 296 pp., £20.00......Review of 'Inglorious Empire: What the British did to India' by Shashi Tharoor, London, Hurst Publishers, 2017, 296 pp., £20.00...

  8. Integrated transcriptomic and proteomic analysis of the molecular cargo of extracellular vesicles derived from porcine adipose tissue-derived mesenchymal stem cells

    OpenAIRE

    Eirin, Alfonso; Zhu, Xiang-Yang; Puranik, Amrutesh S.; Woollard, John R.; Tang, Hui; Dasari, Surendra; Lerman, Amir; van Wijnen, Andre J.; Lerman, Lilach O.

    2017-01-01

    Background Mesenchymal stromal/stem cell (MSC) transplantation is a promising therapy for tissue regeneration. Extracellular vesicles (EVs) released by MSCs act as their paracrine effectors by delivering proteins and genetic material to recipient cells. To assess how their cargo mediates biological processes that drive their therapeutic effects, we integrated miRNA, mRNA, and protein expression data of EVs from porcine adipose tissue-derived MSCs. Methods Simultaneous expression profiles of m...

  9. Knowledge-Perception Bridge of Green-Smart Integration of Cities: An Empirical Study of Hong Kong

    Directory of Open Access Journals (Sweden)

    Chung-Shing Chan

    2018-01-01

    Full Text Available Cities often thematize themselves as attractive and sustainable places by adopting some emerging concepts of urban development. Green city and smart city are two of these themes that contain distinctive but often overlapping attributes. These green and smart city attributes, as proposed in previous studies, are tested with a sample of Hong Kong residents (n = 243. This paper identifies the factors in a combined green–smart theme of Hong Kong based on local perception. The empirical results confirm that local residents believe Hong Kong is performing smarter than greener. The findings from factor analysis reveal a combined green–smart structure consisting of one mixed green–smart infrastructural elements and six other specific factors about greenness or smartness. Regression also builds up two models showing the locally-perceived determinants of a successful green city and smart city for Hong Kong, respectively. This study reflects a complexity–simplicity paradox of how decision makers should respond to a knowledge–perception gap. The result further confirms that human factor, including the engagement and the quality of societal actors, is the key to successful green and smart urban development.

  10. Single-Trial Classification of Bistable Perception by Integrating Empirical Mode Decomposition, Clustering, and Support Vector Machine

    Directory of Open Access Journals (Sweden)

    Hualou Liang

    2008-04-01

    Full Text Available We propose an empirical mode decomposition (EMD- based method to extract features from the multichannel recordings of local field potential (LFP, collected from the middle temporal (MT visual cortex in a macaque monkey, for decoding its bistable structure-from-motion (SFM perception. The feature extraction approach consists of three stages. First, we employ EMD to decompose nonstationary single-trial time series into narrowband components called intrinsic mode functions (IMFs with time scales dependent on the data. Second, we adopt unsupervised K-means clustering to group the IMFs and residues into several clusters across all trials and channels. Third, we use the supervised common spatial patterns (CSP approach to design spatial filters for the clustered spatiotemporal signals. We exploit the support vector machine (SVM classifier on the extracted features to decode the reported perception on a single-trial basis. We demonstrate that the CSP feature of the cluster in the gamma frequency band outperforms the features in other frequency bands and leads to the best decoding performance. We also show that the EMD-based feature extraction can be useful for evoked potential estimation. Our proposed feature extraction approach may have potential for many applications involving nonstationary multivariable time series such as brain-computer interfaces (BCI.

  11. Financial development and investment market integration: An approach of underlying financial variables & indicators for corporate governance growth empirical approach

    Directory of Open Access Journals (Sweden)

    Vojinovič Borut

    2005-01-01

    Full Text Available Financial development is correlated with several underlying regulatory variables (such as indicators of investor protection, market transparency variables for corporate governance growth and rules for capital market development, which are under the control of national legislators and EU directives. This paper provides estimates of the relationship between financial market development and corporate growth and assesses the impact of financial market integration on this relationship with reference to European Union (EU countries. The regression results obtained using this panel support the hypothesis that financial development promotes growth particularly in industries that are more financially dependent on external finance. For policy purposes, analyzing changes in these regulatory variables may be a more interesting exercise than analyzing integration of the financial systems themselves. Since assuming that EU countries will raise its regulatory and legal standards to the U.S. standards appears unrealistic, in this case we examine a scenario where EU countries raise their standards to the highest current EU standard.

  12. Carbon dioxide abatement in an empirical model of the Indian economy: an integration of micro and macro analysis

    International Nuclear Information System (INIS)

    Gupta, S.

    1995-01-01

    Global warming and associated climate change are the likely results of an enhanced greenhouse effect due to excessive emission of greenhouse gases. Carbon dioxide (CO 2 ) is the largest contributor to the greenhouse effect. The costs of stabilising or reducing CO 2 emissions are estimated by two types of models. Macro models based on aggregate macroeconomic relationships, study the macroeconomic impacts of and responses to different policies. These overestimate costs as technological responses are not adequately modelled. Micro models contain the necessary technical information to assess the abatement potential, but exclude indirect costs. In this study, a methodology for integrating the two approaches for developing countries is proposed and illustrated for India. The problems associated with modelling developing economies are recognized in the integrated model proposed. (Author)

  13. Research on refugees and immigrants social integration in Yunnan Border Area: An empirical analysis on the multivariable linear regression model

    Directory of Open Access Journals (Sweden)

    Peng Nai

    2016-03-01

    Full Text Available A great number of immigration populations resident permanently in Yunnan Border Area of China. To some extent, these people belong to refugees or immigrants in accordance with International Rules, which significantly features the social diversity of this area. However, this kind of social diversity always impairs the social order. Therefore, there will be a positive influence to the local society governance by a research on local immigration integration. This essay hereby attempts to acquire the data of the living situation of these border area immigration and refugees. The analysis of the social integration of refugees and immigration in Yunnan border area in China will be deployed through the modeling of multivariable linear regression based on these data in order to propose some more achievable resolutions.

  14. Computer-aided assessment of aviation pilots attention: Design of an integrated test and its empirical validation

    Directory of Open Access Journals (Sweden)

    Rosario Cannavò

    2016-01-01

    In this paper, we present a battery of seven computerized tests, encompassing classical and innovative solutions inspired by the literature in the field, for the integrated measurement of the attention factors of aviation pilots. The computer software is validated by means of an experimental trial with 50 experienced aviation pilots and 50 untrained people as controls. Statistical analyzes confirm that the instrument can effectively classify aviation pilots, and identify a subset of distinctive attention factors that could be used for monitoring their duty.

  15. The use of an empirical correlation between surface activity and integrated radon exposure in a retrospective radon measurement

    International Nuclear Information System (INIS)

    Cauwels, P.; Poffijn, A.

    1998-01-01

    Retrospective measurements of integrated radon concentration in dwellings over the past decades are dealt with, based on the fact that glass sheets act as a memory for the airborne radon activity due to the implanted 210 Po and 210 Bi activity. The room model established to this purpose by Jacobi in 1972 seems to need some modifications; calculated and measured data suggest the existence of a possible loss of implanted daughter products. (A.K.)

  16. Integrating across Episodes: Investigating the Long-term Accessibility of Self-derived Knowledge in 4-Year-Old Children

    Science.gov (United States)

    Varga, Nicole L.; Stewart, Rebekah A.; Bauer, Patricia J.

    2016-01-01

    Semantic memory, defined as our store of knowledge about the world, provides representational support for all of our higher order cognitive functions. As such, it is crucial that the contents of semantic memory remain accessible over time. Although memory for knowledge learned through direct observation has been previously investigated, we know very little about the retention of knowledge derived through integration of information acquired across separate learning episodes. The present research investigated cross-episode integration in 4-year-old children. Participants were presented with novel facts via distinct story episodes and tested for knowledge extension through cross-episode integration, as well as for retention of the information over a 1-week delay. In Experiment 1, children retained the self-derived knowledge over the delay, though performance was primarily evidenced in a forced-choice format. In Experiment 2, we sought to facilitate the accessibility and robustness of self-derived knowledge by providing a verbal reminder after the delay. The accessibility of self-derived knowledge increased, irrespective of whether participants successfully demonstrated knowledge of the integration facts during the first visit. The results suggest knowledge extended through integration remains accessible after delays, even in a population in which this learning process is less robust. The findings also demonstrate the facilitative effect of reminders on the accessibility and further extension of knowledge over extended time periods. PMID:26774259

  17. Proportional-Integral-Derivative (PID) Control of Secreted Factors for Blood Stem Cell Culture.

    Science.gov (United States)

    Caldwell, Julia; Wang, Weijia; Zandstra, Peter W

    2015-01-01

    Clinical use of umbilical cord blood has typically been limited by the need to expand hematopoietic stem and progenitor cells (HSPC) ex vivo. This expansion is challenging due to the accumulation of secreted signaling factors in the culture that have a negative regulatory effect on HSPC output. Strategies for global regulation of these factors through dilution have been developed, but do not accommodate the dynamic nature or inherent variability of hematopoietic cell culture. We have developed a mathematical model to simulate the impact of feedback control on in vitro hematopoiesis, and used it to design a proportional-integral-derivative (PID) control algorithm. This algorithm was implemented with a fed-batch bioreactor to regulate the concentrations of secreted factors. Controlling the concentration of a key target factor, TGF-β1, through dilution limited the negative effect it had on HSPCs, and allowed global control of other similarly-produced inhibitory endogenous factors. The PID control algorithm effectively maintained the target soluble factor at the target concentration. We show that feedback controlled dilution is predicted to be a more cost effective dilution strategy compared to other open-loop strategies, and can enhance HSPC expansion in short term culture. This study demonstrates the utility of secreted factor process control strategies to optimize stem cell culture systems, and motivates the development of multi-analyte protein sensors to automate the manufacturing of cell therapies.

  18. Design of proportional-integral-derivative type optimal controller for a nuclear reactor

    International Nuclear Information System (INIS)

    Pal, Jayanta

    1976-01-01

    A theoretic approach to the design of a proportional integral derivative (PID) type optimal controller for a nuclear reactor is considered. A linearized version of the state-space model of a nuclear-reactor-plant is investigated which shows very 'sluggish' response (settling time of the order of 600 seconds) to changes in the power demand and frequency. It is shown that with a judicious choice of state variables a PID type optimal controller realisation is possible. A controller is designed to minimise the effects of (a) a sudden increase or decrease in the electrical power demand (b) change in frequency at grid. The above controller, designed for a tracking problem, reduces the steady-state error (in response to a step input) to zero and the dynamics of the system become 'faster' (setting time of the order of 100 seconds). The controller is also insensitive to changes in system parameters. The superiority in the performance of the system with the optimal PID controller as compared with that of the conventional regulator is conclusively established. (author)

  19. Association between empirically derived dietary patterns with blood lipids, fasting blood glucose and blood pressure in adults - the India migration study.

    Science.gov (United States)

    Shridhar, Krithiga; Satija, Ambika; Dhillon, Preet K; Agrawal, Sutapa; Gupta, Ruby; Bowen, Liza; Kinra, Sanjay; Bharathi, A V; Prabhakaran, D; Srinath Reddy, K; Ebrahim, Shah

    2018-02-08

    Dietary patterns (DPs) in India are heterogenous. To date, data on association of indigenous DPs in India with risk factors of nutrition-related noncommunicable diseases (cardiovascular disease and diabetes), leading causes of premature death and disability, are limited. We aimed to evaluate the associations of empirically-derived DPs with blood lipids, fasting glucose and blood pressure levels in an adult Indian population recruited across four geographical regions of India. We used cross-sectional data from the Indian Migration Study (2005-2007). Study participants included urban migrants, their rural siblings and urban residents and their urban siblings from Lucknow, Nagpur, Hyderabad and Bangalore (n = 7067, mean age 40.8 yrs). Information on diet (validated interviewer-administered, 184-item semi-quantitative food frequency questionnaire), tobacco consumption, alcohol intake, physical activity, medical history, as well as anthropometric measurements were collected. Fasting-blood samples were collected for estimation of blood lipids and glucose. Principal component analysis (PCA) was used to identify major DPs based on eigenvalue> 1 and component interpretability. Robust standard error multivariable linear regression models were used to investigate the association of DPs (tertiles) with total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides, fasting-blood glucose (FBG), systolic and diastolic blood pressure (SBP and DBP) levels. Three major DPs were identified: 'cereal-savoury' (cooked grains, rice/rice-based dishes, snacks, condiments, soups, nuts), 'fruit-vegetable-sweets-snacks' (Western cereals, vegetables, fruit, fruit juices, cooked milk products, snacks, sugars, sweets) and 'animal food' (red meat, poultry, fish/seafood, eggs) patterns. High intake of the 'animal food' pattern was positively associated with levels of TC (β = 0.10 mmol/L; 95% CI: 0.02, 0.17 mmol/L; p

  20. An Empirical study of the Co-integration of the Indian stock market with select Stock Exchanges

    Directory of Open Access Journals (Sweden)

    Smita RAMAKRISHNA

    2017-07-01

    Full Text Available Fluctuations in the stock market can have an intense economic impact on the economy. This paper studies the inter-linkages between select stock markets. Daily closing levels of the benchmark indices are taken for a period of 15 years. The stationarity of the series has checked by applying line charts and unit-root test. Granger’s causality model and Vector Auto Regression (VAR model are performed to identify the integration among the markets chosen for study. The series was found to be stationary. Granger’s causality indicated that there is a causation effect by some of the markets uni-directionally. The results of Granger Causality test indicate a unidirectional causality from the Indian Market to Canada and China. In the reverse direction, Korea causes movements in the Indian markets

  1. Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model

    DEFF Research Database (Denmark)

    Tønnesen, Jan; Parish, Clare L; Sørensen, Andreas T

    2011-01-01

    Intrastriatal grafts of stem cell-derived dopamine (DA) neurons induce behavioral recovery in animal models of Parkinson's disease (PD), but how they functionally integrate in host neural circuitries is poorly understood. Here, Wnt5a-overexpressing neural stem cells derived from embryonic ventral...... of post-synaptic currents, and functional expression of DA D₂ autoreceptors. These properties resembled those recorded from identical cells in acute slices of intrastriatal grafts in the 6-hydroxy-DA-induced mouse PD model and from DA neurons in intact substantia nigra. Optogenetic activation...... using optogenetics that ectopically grafted stem cell-derived DA neurons become functionally integrated in the DA-denervated striatum. Further optogenetic dissection of the synaptic wiring between grafted and host neurons will be crucial to clarify the cellular and synaptic mechanisms underlying...

  2. Integration of Synthetic Aperture Radar (SAR) Imagery and Derived Products into Severe Weather Disaster Response

    Science.gov (United States)

    Schultz, L. A.; Molthan, A.; Nicoll, J. B.; Bell, J. R.; Gens, R.; Meyer, F. J.

    2017-12-01

    Disaster response efforts leveraging imagery from NASA, USGS, NOAA, and the European Space Agency (ESA) have continued to expand as satellite imagery and derived products offer an enhanced overview of the affected areas, especially in remote areas where terrain and the scale of the damage can inhibit response efforts. NASA's Short-term Prediction Research and Transition (SPoRT) Center has been supporting the NASA Earth Science Disaster Response Program by providing both optical and SAR imagery products to the NWS and FEMA to assist during domestic response efforts. Although optical imagery has dominated, the availability of ESA's Synthetic Aperture Radar (SAR) data from the Sentinel 1-A/B satellites offers a unique perspective to the damage response community as SAR imagery can be collected regardless of the time of day or the presence of clouds, two major hindrances to the use of satellite optical imagery. Through a partnership with the University of Alaska Fairbanks (UAF) and the collocated Alaska Satellite Facility (ASF), NASA's SAR Distributed Active Archive Center (DAAC), SPoRT has been investigating the use of SAR imagery products to support storm damage surveys conducted by the National Weather Service after any severe weather event. Additionally, products are also being developed and tested for FEMA and the National Guard Bureau. This presentation will describe how SAR data from the Sentinel 1A/B satellites are processed and developed into products. Examples from multiple tornado and hail events will be presented highlighting both the strengths and weaknesses of SAR imagery and how it integrates and compliments more traditional optical imagery collected post-event. Specific case study information from a large hail event in South Dakota and a long track tornado near Clear Lake, Wisconsin will be discussed as well as an overview of the work being done to support FEMA and the National Guard.

  3. Valuing fire planning alternatives in forest restoration: using derived demand to integrate economics with ecological restoration.

    Science.gov (United States)

    Rideout, Douglas B; Ziesler, Pamela S; Kernohan, Nicole J

    2014-08-01

    Assessing the value of fire planning alternatives is challenging because fire affects a wide array of ecosystem, market, and social values. Wildland fire management is increasingly used to address forest restoration while pragmatic approaches to assessing the value of fire management have yet to be developed. Earlier approaches to assessing the value of forest management relied on connecting site valuation with management variables. While sound, such analysis is too narrow to account for a broad range of ecosystem services. The metric fire regime condition class (FRCC) was developed from ecosystem management philosophy, but it is entirely biophysical. Its lack of economic information cripples its utility to support decision-making. We present a means of defining and assessing the deviation of a landscape from its desired fire management condition by re-framing the fire management problem as one of derived demand. This valued deviation establishes a performance metric for wildland fire management. Using a case study, we display the deviation across a landscape and sum the deviations to produce a summary metric. This summary metric is used to assess the value of alternative fire management strategies on improving the fire management condition toward its desired state. It enables us to identify which sites are most valuable to restore, even when they are in the same fire regime condition class. The case study site exemplifies how a wide range of disparate values, such as watershed, wildlife, property and timber, can be incorporated into a single landscape assessment. The analysis presented here leverages previous research on environmental capital value and non-market valuation by integrating ecosystem management, restoration, and microeconomics. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Empirical likelihood

    CERN Document Server

    Owen, Art B

    2001-01-01

    Empirical likelihood provides inferences whose validity does not depend on specifying a parametric model for the data. Because it uses a likelihood, the method has certain inherent advantages over resampling methods: it uses the data to determine the shape of the confidence regions, and it makes it easy to combined data from multiple sources. It also facilitates incorporating side information, and it simplifies accounting for censored, truncated, or biased sampling.One of the first books published on the subject, Empirical Likelihood offers an in-depth treatment of this method for constructing confidence regions and testing hypotheses. The author applies empirical likelihood to a range of problems, from those as simple as setting a confidence region for a univariate mean under IID sampling, to problems defined through smooth functions of means, regression models, generalized linear models, estimating equations, or kernel smooths, and to sampling with non-identically distributed data. Abundant figures offer vi...

  5. A Liouville-operator derived measure-preserving integrator for molecular dynamics simulations in the isothermal-isobaric ensemble

    International Nuclear Information System (INIS)

    Tuckerman, Mark E; Alejandre, Jose; Lopez-Rendon, Roberto; Jochim, Andrea L; Martyna, Glenn J

    2006-01-01

    The constant-pressure, constant-temperature (NPT) molecular dynamics approach is re-examined from the viewpoint of deriving a new measure-preserving reversible geometric integrator for the equations of motion. The underlying concepts of non-Hamiltonian phase-space analysis, measure-preserving integrators and the symplectic property for Hamiltonian systems are briefly reviewed. In addition, current measure-preserving schemes for the constant-volume, constant-temperature ensemble are also reviewed. A new geometric integrator for the NPT method is presented, is shown to preserve the correct phase-space volume element and is demonstrated to perform well in realistic examples. Finally, a multiple time-step version of the integrator is presented for treating systems with motion on several time scales

  6. The hematopoietic chemokine CXCL12 promotes integration of human endothelial colony forming cell-derived cells into immature vessel networks.

    Science.gov (United States)

    Newey, Sarah E; Tsaknakis, Grigorios; Khoo, Cheen P; Athanassopoulos, Thanassi; Camicia, Rosalba; Zhang, Youyi; Grabowska, Rita; Harris, Adrian L; Roubelakis, Maria G; Watt, Suzanne M

    2014-11-15

    Proangiogenic factors, vascular endothelial growth factor (VEGF), and fibroblast growth factor-2 (FGF-2) prime endothelial cells to respond to "hematopoietic" chemokines and cytokines by inducing/upregulating expression of the respective chemokine/cytokine receptors. Coculture of human endothelial colony forming cell (ECFC)-derived cells with human stromal cells in the presence of VEGF and FGF-2 for 14 days resulted in upregulation of the "hematopoietic" chemokine CXCL12 and its CXCR4 receptor by day 3 of coculture. Chronic exposure to the CXCR4 antagonist AMD3100 in this vasculo/angiogenesis assay significantly reduced vascular tubule formation, an observation recapitulated by delayed AMD3100 addition. While AMD3100 did not affect ECFC-derived cell proliferation, it did demonstrate a dual action. First, over the later stages of the 14-day cocultures, AMD3100 delayed tubule organization into maturing vessel networks, resulting in enhanced endothelial cell retraction and loss of complexity as defined by live cell imaging. Second, at earlier stages of cocultures, we observed that AMD3100 significantly inhibited the integration of exogenous ECFC-derived cells into established, but immature, vascular networks. Comparative proteome profiler array analyses of ECFC-derived cells treated with AMD3100 identified changes in expression of potential candidate molecules involved in adhesion and/or migration. Blocking antibodies to CD31, but not CD146 or CD166, reduced the ECFC-derived cell integration into these extant vascular networks. Thus, CXCL12 plays a key role not only in endothelial cell sensing and guidance, but also in promoting the integration of ECFC-derived cells into developing vascular networks.

  7. Empire vs. Federation

    DEFF Research Database (Denmark)

    Gravier, Magali

    2011-01-01

    The article discusses the concepts of federation and empire in the context of the European Union (EU). Even if these two concepts are not usually contrasted to one another, the article shows that they refer to related type of polities. Furthermore, they can be used at a time because they shed light...... on different and complementary aspects of the European integration process. The article concludes that the EU is at the crossroads between federation and empire and may remain an ‘imperial federation’ for several decades. This could mean that the EU is on the verge of transforming itself to another type...

  8. Analytic, empirical and delta method temperature derivatives of D-D and D-T fusion reactivity formulations, as a means of verification

    Energy Technology Data Exchange (ETDEWEB)

    Langenbrunner, James R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Booker, Jane M. [Booker Scientific, Fredericksburg, TX (United States)

    2017-07-21

    We examine the derivatives with respect to temperature, for various deuterium-tritium (DT) and deuterium-deuterium (D-D) fusion-reactivity formulations. Langenbrunner and Makaruk [1] had studied this as a means of understanding the time and temperature domain of reaction history measured in dynamic fusion experiments. Presently, we consider the temperature derivative dependence of fusion reactivity as a means of exercising and verifying the consistency of the various reactivity formulations.

  9. What 'empirical turn in bioethics'?

    Science.gov (United States)

    Hurst, Samia

    2010-10-01

    Uncertainty as to how we should articulate empirical data and normative reasoning seems to underlie most difficulties regarding the 'empirical turn' in bioethics. This article examines three different ways in which we could understand 'empirical turn'. Using real facts in normative reasoning is trivial and would not represent a 'turn'. Becoming an empirical discipline through a shift to the social and neurosciences would be a turn away from normative thinking, which we should not take. Conducting empirical research to inform normative reasoning is the usual meaning given to the term 'empirical turn'. In this sense, however, the turn is incomplete. Bioethics has imported methodological tools from empirical disciplines, but too often it has not imported the standards to which researchers in these disciplines are held. Integrating empirical and normative approaches also represents true added difficulties. Addressing these issues from the standpoint of debates on the fact-value distinction can cloud very real methodological concerns by displacing the debate to a level of abstraction where they need not be apparent. Ideally, empirical research in bioethics should meet standards for empirical and normative validity similar to those used in the source disciplines for these methods, and articulate these aspects clearly and appropriately. More modestly, criteria to ensure that none of these standards are completely left aside would improve the quality of empirical bioethics research and partly clear the air of critiques addressing its theoretical justification, when its rigour in the particularly difficult context of interdisciplinarity is what should be at stake.

  10. pKWmEB: integration of Kruskal-Wallis test with empirical Bayes under polygenic background control for multi-locus genome-wide association study.

    Science.gov (United States)

    Ren, Wen-Long; Wen, Yang-Jun; Dunwell, Jim M; Zhang, Yuan-Ming

    2018-03-01

    Although nonparametric methods in genome-wide association studies (GWAS) are robust in quantitative trait nucleotide (QTN) detection, the absence of polygenic background control in single-marker association in genome-wide scans results in a high false positive rate. To overcome this issue, we proposed an integrated nonparametric method for multi-locus GWAS. First, a new model transformation was used to whiten the covariance matrix of polygenic matrix K and environmental noise. Using the transferred model, Kruskal-Wallis test along with least angle regression was then used to select all the markers that were potentially associated with the trait. Finally, all the selected markers were placed into multi-locus model, these effects were estimated by empirical Bayes, and all the nonzero effects were further identified by a likelihood ratio test for true QTN detection. This method, named pKWmEB, was validated by a series of Monte Carlo simulation studies. As a result, pKWmEB effectively controlled false positive rate, although a less stringent significance criterion was adopted. More importantly, pKWmEB retained the high power of Kruskal-Wallis test, and provided QTN effect estimates. To further validate pKWmEB, we re-analyzed four flowering time related traits in Arabidopsis thaliana, and detected some previously reported genes that were not identified by the other methods.

  11. A Theoretical and Empirical Integrated Method to Select the Optimal Combined Signals for Geometry-Free and Geometry-Based Three-Carrier Ambiguity Resolution.

    Science.gov (United States)

    Zhao, Dongsheng; Roberts, Gethin Wyn; Lau, Lawrence; Hancock, Craig M; Bai, Ruibin

    2016-11-16

    Twelve GPS Block IIF satellites, out of the current constellation, can transmit on three-frequency signals (L1, L2, L5). Taking advantages of these signals, Three-Carrier Ambiguity Resolution (TCAR) is expected to bring much benefit for ambiguity resolution. One of the research areas is to find the optimal combined signals for a better ambiguity resolution in geometry-free (GF) and geometry-based (GB) mode. However, the existing researches select the signals through either pure theoretical analysis or testing with simulated data, which might be biased as the real observation condition could be different from theoretical prediction or simulation. In this paper, we propose a theoretical and empirical integrated method, which first selects the possible optimal combined signals in theory and then refines these signals with real triple-frequency GPS data, observed at eleven baselines of different lengths. An interpolation technique is also adopted in order to show changes of the AR performance with the increase in baseline length. The results show that the AR success rate can be improved by 3% in GF mode and 8% in GB mode at certain intervals of the baseline length. Therefore, the TCAR can perform better by adopting the combined signals proposed in this paper when the baseline meets the length condition.

  12. Empirical philosophy of science

    DEFF Research Database (Denmark)

    Wagenknecht, Susann; Nersessian, Nancy J.; Andersen, Hanne

    2015-01-01

    A growing number of philosophers of science make use of qualitative empirical data, a development that may reconfigure the relations between philosophy and sociology of science and that is reminiscent of efforts to integrate history and philosophy of science. Therefore, the first part...... of this introduction to the volume Empirical Philosophy of Science outlines the history of relations between philosophy and sociology of science on the one hand, and philosophy and history of science on the other. The second part of this introduction offers an overview of the papers in the volume, each of which...... is giving its own answer to questions such as: Why does the use of qualitative empirical methods benefit philosophical accounts of science? And how should these methods be used by the philosopher?...

  13. DERIVING METALLICITIES FROM THE INTEGRATED SPECTRA OF EXTRAGALACTIC GLOBULAR CLUSTERS USING THE NEAR-INFRARED CALCIUM TRIPLET

    International Nuclear Information System (INIS)

    Foster, Caroline; Forbes, Duncan A.; Proctor, Robert N.; Spitler, Lee R.; Strader, Jay; Brodie, Jean P.

    2010-01-01

    The Ca II triplet (CaT) feature in the near-infrared has been employed as a metallicity indicator for individual stars as well as integrated light of Galactic globular clusters (GCs) and galaxies with varying degrees of success, and sometimes puzzling results. Using the DEIMOS multi-object spectrograph on Keck we obtain a sample of 144 integrated light spectra of GCs around the brightest group galaxy NGC 1407 to test whether the CaT index can be used as a metallicity indicator for extragalactic GCs. Different sets of single stellar population models make different predictions for the behavior of the CaT as a function of metallicity. In this work, the metallicities of the GCs around NGC 1407 are obtained from CaT index values using an empirical conversion. The measured CaT/metallicity distributions show unexpected features, the most remarkable being that the brightest red and blue GCs have similar CaT values despite their large difference in mean color. Suggested explanations for this behavior in the NGC 1407 GC system are (1) the CaT may be affected by a population of hot blue stars, (2) the CaT may saturate earlier than predicted by the models, and/or (3) color may not trace metallicity linearly. Until these possibilities are understood, the use of the CaT as a metallicity indicator for the integrated spectra of extragalactic GCs will remain problematic.

  14. Explicit Time Integrators for Nonlinear Dynamics Derived from the Midpoint Rule

    Directory of Open Access Journals (Sweden)

    P. Krysl

    2004-01-01

    Full Text Available We address the design of time integrators for mechanical systems that are explicit in the forcing evaluations. Our starting point is the midpoint rule, either in the classical form for the vector space setting, or in the Lie form for the rotation group. By introducing discrete, concentrated impulses we can approximate the forcing impressed upon the system over the time step, and thus arrive at first-order integrators. These can then be composed to yield a second order integrator with very desirable properties: symplecticity and momentum conservation. 

  15. Second-order domain derivative of normal-dependent boundary integrals

    KAUST Repository

    Balzer, Jonathan

    2010-01-01

    Numerous reconstruction tasks in (optical) surface metrology allow for a variational formulation. The occurring boundary integrals may be interpreted as shape functions. The paper is concerned with the second-order analysis of such functions. Shape

  16. Generation and periodontal differentiation of human gingival fibroblasts-derived integration-free induced pluripotent stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Yin, Xiaohui [Department of Periodontology, School and Hospital of Stomatology, Peking University, 22 South Avenue Zhong-Guan-Cun, Beijing 100081 (China); Peking University Stem Cell Research Center and Department of Cell Biology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191 (China); Li, Yang [Peking University Stem Cell Research Center and Department of Cell Biology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191 (China); Li, Jingwen [Department of Periodontology, School and Hospital of Stomatology, Peking University, 22 South Avenue Zhong-Guan-Cun, Beijing 100081 (China); Li, Peng [Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Hong Kong SAR (China); Liu, Yinan [Peking University Stem Cell Research Center and Department of Cell Biology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191 (China); Wen, Jinhua, E-mail: jhwen@bjmu.edu.cn [Peking University Stem Cell Research Center and Department of Cell Biology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191 (China); Luan, Qingxian, E-mail: kqluanqx@126.com [Department of Periodontology, School and Hospital of Stomatology, Peking University, 22 South Avenue Zhong-Guan-Cun, Beijing 100081 (China)

    2016-05-06

    Induced pluripotent stem cells (iPSCs) have been recognized as a promising cell source for periodontal tissue regeneration. However, the conventional virus-based reprogramming approach is associated with a high risk of genetic mutation and limits their therapeutic utility. Here, we successfully generated iPSCs from readily accessible human gingival fibroblasts (hGFs) through an integration-free and feeder-free approach via delivery of reprogramming factors of Oct4, Sox2, Klf4, L-myc, Lin28 and TP53 shRNA with episomal plasmid vectors. The iPSCs presented similar morphology and proliferation characteristics as embryonic stem cells (ESCs), and expressed pluripotent markers including Oct4, Tra181, Nanog and SSEA-4. Additionally, these cells maintained a normal karyotype and showed decreased CpG methylation ratio in the promoter regions of Oct4 and Nanog. In vivo teratoma formation assay revealed the development of tissues representative of three germ layers, confirming the acquisition of pluripotency. Furthermore, treatment of the iPSCs in vitro with enamel matrix derivative (EMD) or growth/differentiation factor-5 (GDF-5) significantly up-regulated the expression of periodontal tissue markers associated with bone, periodontal ligament and cementum respectively. Taken together, our data demonstrate that hGFs are a valuable cell source for generating integration-free iPSCs, which could be sequentially induced toward periodontal cells under the treatment of EMD and GDF-5. - Highlights: • Integration-free iPSCs are successfully generated from hGFs via an episomal approach. • EMD promotes differentiation of the hGFs-derived iPSCs toward periodontal cells. • GDF-5 promotes differentiation of the hGFs-derived iPSCs toward periodontal cells. • hGFs-derived iPSCs could be a promising cell source for periodontal regeneration.

  17. Generation and periodontal differentiation of human gingival fibroblasts-derived integration-free induced pluripotent stem cells

    International Nuclear Information System (INIS)

    Yin, Xiaohui; Li, Yang; Li, Jingwen; Li, Peng; Liu, Yinan; Wen, Jinhua; Luan, Qingxian

    2016-01-01

    Induced pluripotent stem cells (iPSCs) have been recognized as a promising cell source for periodontal tissue regeneration. However, the conventional virus-based reprogramming approach is associated with a high risk of genetic mutation and limits their therapeutic utility. Here, we successfully generated iPSCs from readily accessible human gingival fibroblasts (hGFs) through an integration-free and feeder-free approach via delivery of reprogramming factors of Oct4, Sox2, Klf4, L-myc, Lin28 and TP53 shRNA with episomal plasmid vectors. The iPSCs presented similar morphology and proliferation characteristics as embryonic stem cells (ESCs), and expressed pluripotent markers including Oct4, Tra181, Nanog and SSEA-4. Additionally, these cells maintained a normal karyotype and showed decreased CpG methylation ratio in the promoter regions of Oct4 and Nanog. In vivo teratoma formation assay revealed the development of tissues representative of three germ layers, confirming the acquisition of pluripotency. Furthermore, treatment of the iPSCs in vitro with enamel matrix derivative (EMD) or growth/differentiation factor-5 (GDF-5) significantly up-regulated the expression of periodontal tissue markers associated with bone, periodontal ligament and cementum respectively. Taken together, our data demonstrate that hGFs are a valuable cell source for generating integration-free iPSCs, which could be sequentially induced toward periodontal cells under the treatment of EMD and GDF-5. - Highlights: • Integration-free iPSCs are successfully generated from hGFs via an episomal approach. • EMD promotes differentiation of the hGFs-derived iPSCs toward periodontal cells. • GDF-5 promotes differentiation of the hGFs-derived iPSCs toward periodontal cells. • hGFs-derived iPSCs could be a promising cell source for periodontal regeneration.

  18. Symplectic Integrators to Stochastic Hamiltonian Dynamical Systems Derived from Composition Methods

    Directory of Open Access Journals (Sweden)

    Tetsuya Misawa

    2010-01-01

    Full Text Available “Symplectic” schemes for stochastic Hamiltonian dynamical systems are formulated through “composition methods (or operator splitting methods” proposed by Misawa (2001. In the proposed methods, a symplectic map, which is given by the solution of a stochastic Hamiltonian system, is approximated by composition of the stochastic flows derived from simpler Hamiltonian vector fields. The global error orders of the numerical schemes derived from the stochastic composition methods are provided. To examine the superiority of the new schemes, some illustrative numerical simulations on the basis of the proposed schemes are carried out for a stochastic harmonic oscillator system.

  19. A time use survey derived integrative human-physical household system energy performance model

    Energy Technology Data Exchange (ETDEWEB)

    Chiou, Y.S. [Carnegie Mellon Univ., Pittsburgh, PA (United States). School of Architecture

    2009-07-01

    This paper reported on a virtual experiment that extrapolated the stochastic yet patterned behaviour of the integrative model of a 4-bedroom house in Chicago with 4 different household compositions. The integrative household system theory considers the household as a combination of 2 sub-systems, notably the physical system and the human system. The physical system is the materials and devices of a dwelling, and the human system is the occupants that live within the dwelling. A third element is the environment that influences the operation of the 2 sub-systems. The human-physical integrative household energy model provided a platform to simulate the effect of sub-house energy conservation measures. The virtual experiment showed that the use of the bootstrap sampling approach on American Time Use Survey (ATUS) data to determine the occupant's stochastic energy consumption behaviour has resulted in a robust complex system model. Bell-shaped distributions were presented for annual appliance, heating and cooling load demands. The virtual experiment also pointed to the development of advanced multi-zone residential HVAC system as a suitable strategy for major residential energy efficiency improvement. The load profiles generated from the integrative model simulation were found to be in good agreement with those from field studies. It was concluded that the behaviour of the integrative model is a good representation of the energy consumption behaviour of real households. 10 refs., 4 tabs., 12 figs.

  20. Subthreshold membrane currents confer distinct tuning properties that enable neurons to encode the integral or derivative of their input

    Directory of Open Access Journals (Sweden)

    Stephanie eRatté

    2015-01-01

    Full Text Available Neurons rely on action potentials, or spikes, to encode information. But spikes can encode different stimulus features in different neurons. We show here through simulations and experiments how neurons encode the integral or derivative of their input based on the distinct tuning properties conferred upon them by subthreshold currents. Slow-activating subthreshold inward (depolarizing current mediates positive feedback control of subthreshold voltage, sustaining depolarization and allowing the neuron to spike on the basis of its integrated stimulus waveform. Slow-activating subthreshold outward (hyperpolarizing current mediates negative feedback control of subthreshold voltage, truncating depolarization and forcing the neuron to spike on the basis of its differentiated stimulus waveform. Depending on its direction, slow-activating subthreshold current cooperates or competes with fast-activating inward current during spike initiation. This explanation predicts that sensitivity to the rate of change of stimulus intensity differs qualitatively between integrators and differentiators. This was confirmed experimentally in spinal sensory neurons that naturally behave as specialized integrators or differentiators. Predicted sensitivity to different stimulus features was confirmed by covariance analysis. Integration and differentiation, which are themselves inverse operations, are thus shown to be implemented by the slow feedback mediated by oppositely directed subthreshold currents expressed in different neurons.

  1. Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model.

    Directory of Open Access Journals (Sweden)

    Jan Tønnesen

    Full Text Available Intrastriatal grafts of stem cell-derived dopamine (DA neurons induce behavioral recovery in animal models of Parkinson's disease (PD, but how they functionally integrate in host neural circuitries is poorly understood. Here, Wnt5a-overexpressing neural stem cells derived from embryonic ventral mesencephalon of tyrosine hydroxylase-GFP transgenic mice were expanded as neurospheres and transplanted into organotypic cultures of wild type mouse striatum. Differentiated GFP-labeled DA neurons in the grafts exhibited mature neuronal properties, including spontaneous firing of action potentials, presence of post-synaptic currents, and functional expression of DA D₂ autoreceptors. These properties resembled those recorded from identical cells in acute slices of intrastriatal grafts in the 6-hydroxy-DA-induced mouse PD model and from DA neurons in intact substantia nigra. Optogenetic activation or inhibition of grafted cells and host neurons using channelrhodopsin-2 (ChR2 and halorhodopsin (NpHR, respectively, revealed complex, bi-directional synaptic interactions between grafted cells and host neurons and extensive synaptic connectivity within the graft. Our data demonstrate for the first time using optogenetics that ectopically grafted stem cell-derived DA neurons become functionally integrated in the DA-denervated striatum. Further optogenetic dissection of the synaptic wiring between grafted and host neurons will be crucial to clarify the cellular and synaptic mechanisms underlying behavioral recovery as well as adverse effects following stem cell-based DA cell replacement strategies in PD.

  2. Stability and square integrability of derivatives of solutions of nonlinear fourth order differential equations with delay.

    Science.gov (United States)

    Korkmaz, Erdal

    2017-01-01

    In this paper, we give sufficient conditions for the boundedness, uniform asymptotic stability and square integrability of the solutions to a certain fourth order non-autonomous differential equations with delay by using Lyapunov's second method. The results obtained essentially improve, include and complement the results in the literature.

  3. Stability and square integrability of derivatives of solutions of nonlinear fourth order differential equations with delay

    Directory of Open Access Journals (Sweden)

    Erdal Korkmaz

    2017-06-01

    Full Text Available Abstract In this paper, we give sufficient conditions for the boundedness, uniform asymptotic stability and square integrability of the solutions to a certain fourth order non-autonomous differential equations with delay by using Lyapunov’s second method. The results obtained essentially improve, include and complement the results in the literature.

  4. MASSCLEANCOLORS-MASS-DEPENDENT INTEGRATED COLORS FOR STELLAR CLUSTERS DERIVED FROM 30 MILLION MONTE CARLO SIMULATIONS

    International Nuclear Information System (INIS)

    Popescu, Bogdan; Hanson, M. M.

    2010-01-01

    We present Monte Carlo models of open stellar clusters with the purpose of mapping out the behavior of integrated colors with mass and age. Our cluster simulation package allows for stochastic variations in the stellar mass function to evaluate variations in integrated cluster properties. We find that UBVK colors from our simulations are consistent with simple stellar population (SSP) models, provided the cluster mass is large, M cluster ≥ 10 6 M sun . Below this mass, our simulations show two significant effects. First, the mean value of the distribution of integrated colors moves away from the SSP predictions and is less red, in the first 10 7 to 10 8 years in UBV colors, and for all ages in (V - K). Second, the 1σ dispersion of observed colors increases significantly with lower cluster mass. We attribute the former to the reduced number of red luminous stars in most of the lower mass clusters and the latter to the increased stochastic effect of a few of these stars on lower mass clusters. This latter point was always assumed to occur, but we now provide the first public code able to quantify this effect. We are completing a more extensive database of magnitudes and colors as a function of stellar cluster age and mass that will allow the determination of the correlation coefficients among different bands, and improve estimates of cluster age and mass from integrated photometry.

  5. Algebraic Bethe ansatz for a quantum integrable derivative nonlinear Schroedinger model

    International Nuclear Information System (INIS)

    Basu-Mallick, B.; Bhattacharyya, Tanaya

    2002-01-01

    We find that the quantum monodromy matrix associated with a derivative nonlinear Schroedinger (DNLS) model exhibits U(2) or U(1,1) symmetry depending on the sign of the related coupling constant. By using a variant of quantum inverse scattering method which is directly applicable to field theoretical models, we derive all possible commutation relations among the operator valued elements of such monodromy matrix. Thus, we obtain the commutation relation between creation and annihilation operators of quasi-particles associated with DNLS model and find out the S-matrix for two-body scattering. We also observe that, for some special values of the coupling constant, there exists an upper bound on the number of quasi-particles which can form a soliton state for the quantum DNLS model

  6. Temporal stability in the genetic structure of Sarcoptes scabiei under the host-taxon law: empirical evidences from wildlife-derived Sarcoptes mite in Asturias, Spain

    Directory of Open Access Journals (Sweden)

    Rossi Luca

    2011-07-01

    Full Text Available Abstract Background Implicitly, parasite molecular studies assume temporal genetic stability. In this study we tested, for the first time to our knowledge, the extent of changes in genetic diversity and structure of Sarcoptes mite populations from Pyrenean chamois (Rupicapra pyrenaica in Asturias (Spain, using one multiplex of 9 microsatellite markers and Sarcoptes samples from sympatric Pyrenean chamois, red deer (Cervus elaphus, roe deer (Capreolus capreolus and red fox (Vulpes vulpes. Results The analysis of an 11-years interval period found little change in the genetic diversity (allelic diversity, and observed and expected heterozygosity. The temporal stability in the genetic diversity was confirmed by population structure analysis, which was not significantly variable over time. Population structure analysis revealed temporal stability in the genetic diversity of Sarcoptes mite under the host-taxon law (herbivore derived- and carnivore derived-Sarcoptes mite among the sympatric wild animals from Asturias. Conclusions The confirmation of parasite temporal genetic stability is of vital interest to allow generalizations to be made, which have further implications regarding the genetic structure, epidemiology and monitoring protocols of the ubiquitous Sarcoptes mite. This could eventually be applied to other parasite species.

  7. Use of derivative instruments to integrate renewable energies into the electricity market

    International Nuclear Information System (INIS)

    Hartmann, Kilian; Nelles, Michael; Candra, Dodiek Ika

    2017-01-01

    The implementation of renewable energies to the electricity market is inefficient and expensive with current measures. Further these measures are prejudicial for the existing energy-only-market. The combination of fluctuating and controllable renewable powers in virtual power plants enables the marketing of this power as a derivate on the future market. Thus would relieve the spot market and stabilize pricing on both markets. Subsequently the renewable energy obligation will reduce and renewable energies could be marketed as secured power.

  8. DEVELOPMENT OF NOVEL CERAMIC NANOFILM-FIBER INTEGRATED OPTICAL SENSORS FOR RAPID DETECTION OF COAL DERIVED SYNTHESIS GAS

    Energy Technology Data Exchange (ETDEWEB)

    Junhang Dong; Hai Xiao; Xiling Tang; Hongmin Jiang; Kurtis Remmel; Amardeep Kaur

    2012-09-30

    The overall goal of this project is to conduct fundamental studies on advanced ceramic materials and fiber optic devices for developing new types of high temperature (>500{degree}C) fiber optic chemical sensors (FOCS) for monitoring fossil (mainly coal) and biomass derived gases in power plants. The primary technical objective is to investigate and demonstrate the nanocrystalline doped-ceramic thin film enabled FOCS that possess desired stability, sensitivity and selectivity for in-situ, rapid gas detection in the syngas streams from gasification and combustion flue gases. This report summarizes research works of two integrated parts: (1) development of metal oxide solid thin films as sensing materials for detection and measurement of important gas components relevant to the coal- and biomass-derived syngas and combustion gas streams at high temperatures; and (2) development of fiber optic devices that are potentially useful for constructing FOCS in combination with the solid oxide thin films identified in this program.

  9. Pluvials, Droughts, Energetics, and the Mongol Empire

    Science.gov (United States)

    Hessl, A. E.; Pederson, N.; Baatarbileg, N.

    2012-12-01

    The success of the Mongol Empire, the largest contiguous land empire the world has ever known, is a historical enigma. At its peak in the late 13th century, the empire influenced areas from the Hungary to southern Asia and Persia. Powered by domesticated herbivores, the Mongol Empire grew at the expense of agriculturalists in Eastern Europe, Persia, and China. What environmental factors contributed to the rise of the Mongols? What factors influenced the disintegration of the empire by 1300 CE? Until now, little high resolution environmental data have been available to address these questions. We use tree-ring records of past temperature and water to illuminate the role of energy and water in the evolution of the Mongol Empire. The study of energetics has long been applied to biological and ecological systems but has only recently become a theme in understanding modern coupled natural and human systems (CNH). Because water and energy are tightly linked in human and natural systems, studying their synergies and interactions make it possible to integrate knowledge across disciplines and human history, yielding important lessons for modern societies. We focus on the role of energy and water in the trajectory of an empire, including its rise, development, and demise. Our research is focused on the Orkhon Valley, seat of the Mongol Empire, where recent paleoenvironmental and archeological discoveries allow high resolution reconstructions of past human and environmental conditions for the first time. Our preliminary records indicate that the period 1210-1230 CE, the height of Chinggis Khan's reign is one of the longest and most consistent pluvials in our tree ring reconstruction of interannual drought. Reconstructed temperature derived from five millennium-long records from subalpine forests in Mongolia document warm temperatures beginning in the early 1200's and ending with a plunge into cold temperatures in 1260. Abrupt cooling in central Mongolia at this time is

  10. Density fitting for derivatives of Coulomb integrals in ab initio calculations using mixed Gaussian and plane-wave basis

    Czech Academy of Sciences Publication Activity Database

    Čársky, Petr

    2009-01-01

    Roč. 109, č. 620 (2009), s. 1237-1242 ISSN 0020-7608 R&D Projects: GA ČR GA203/07/0070; GA ČR GA202/08/0631; GA AV ČR 1ET400400413; GA AV ČR IAA100400501 Institutional research plan: CEZ:AV0Z40400503 Keywords : Derivatives of Coulomb integrals * mixed Gaussian and plane-wave basis sets * electron scattering * computer time saving Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.315, year: 2009

  11. A satellite digital controller or 'play that PID tune again, Sam'. [Position, Integral, Derivative feedback control algorithm for design strategy

    Science.gov (United States)

    Seltzer, S. M.

    1976-01-01

    The problem discussed is to design a digital controller for a typical satellite. The controlled plant is considered to be a rigid body acting in a plane. The controller is assumed to be a digital computer which, when combined with the proposed control algorithm, can be represented as a sampled-data system. The objective is to present a design strategy and technique for selecting numerical values for the control gains (assuming position, integral, and derivative feedback) and the sample rate. The technique is based on the parameter plane method and requires that the system be amenable to z-transform analysis.

  12. Integrating SAR and derived products into operational volcano monitoring and decision support systems

    Science.gov (United States)

    Meyer, F. J.; McAlpin, D. B.; Gong, W.; Ajadi, O.; Arko, S.; Webley, P. W.; Dehn, J.

    2015-02-01

    Remote sensing plays a critical role in operational volcano monitoring due to the often remote locations of volcanic systems and the large spatial extent of potential eruption pre-cursor signals. Despite the all-weather capabilities of radar remote sensing and its high performance in monitoring of change, the contribution of radar data to operational monitoring activities has been limited in the past. This is largely due to: (1) the high costs associated with radar data; (2) traditionally slow data processing and delivery procedures; and (3) the limited temporal sampling provided by spaceborne radars. With this paper, we present new data processing and data integration techniques that mitigate some of these limitations and allow for a meaningful integration of radar data into operational volcano monitoring decision support systems. Specifically, we present fast data access procedures as well as new approaches to multi-track processing that improve near real-time data access and temporal sampling of volcanic systems with SAR data. We introduce phase-based (coherent) and amplitude-based (incoherent) change detection procedures that are able to extract dense time series of hazard information from these data. For a demonstration, we present an integration of our processing system with an operational volcano monitoring system that was developed for use by the Alaska Volcano Observatory (AVO). Through an application to a historic eruption, we show that the integration of SAR into systems such as AVO can significantly improve the ability of operational systems to detect eruptive precursors. Therefore, the developed technology is expected to improve operational hazard detection, alerting, and management capabilities.

  13. Integrating hydrodynamic models and COSMO-SkyMed derived products for flood damage assessment

    Science.gov (United States)

    Giuffra, Flavio; Boni, Giorgio; Pulvirenti, Luca; Pierdicca, Nazzareno; Rudari, Roberto; Fiorini, Mattia

    2015-04-01

    Floods are the most frequent weather disasters in the world and probably the most costly in terms of social and economic losses. They may have a strong impact on infrastructures and health because the range of possible damages includes casualties, loss of housing and destruction of crops. Presently, the most common approach for remotely sensing floods is the use of synthetic aperture radar (SAR) images. Key features of SAR data for inundation mapping are the synoptic view, the capability to operate even in cloudy conditions and during both day and night time and the sensitivity of the microwave radiation to water. The launch of a new generation of instruments, such as TerraSAR-X and COSMO-SkyMed (CSK) allows producing near real time flood maps having a spatial resolution in the order of 1-5 m. Moreover, the present (CSK) and upcoming (Sentinel-1) constellations permit the acquisition of radar data characterized by a short revisit time (in the order of some hours for CSK), so that the production of frequent inundation maps can be envisaged. Nonetheless, gaps might be present in the SAR-derived flood maps because of the limited area imaged by SAR; moreover, the detection of floodwater may be complicated by the presence of very dense vegetation or urban settlements. Hence the need to complement SAR-derived flood maps with the outputs of physical models. Physical models allow delivering to end users very useful information for a complete flood damage assessment, such as data on water depths and flow directions, which cannot be directly derived from satellite remote sensing images. In addition, the flood extent predictions of hydraulic models can be compared to SAR-derived inundation maps to calibrate the models, or to fill the aforementioned gaps that can be present in the SAR-derived maps. Finally, physical models enable the construction of risk scenarios useful for emergency managers to take their decisions and for programming additional SAR acquisitions in order to

  14. Benchmarking DFT and semi-empirical methods for a reliable and cost-efficient computational screening of benzofulvene derivatives as donor materials for small-molecule organic solar cells.

    Science.gov (United States)

    Tortorella, Sara; Talamo, Maurizio Mastropasqua; Cardone, Antonio; Pastore, Mariachiara; De Angelis, Filippo

    2016-02-24

    A systematic computational investigation on the optical properties of a group of novel benzofulvene derivatives (Martinelli 2014 Org. Lett. 16 3424-7), proposed as possible donor materials in small molecule organic photovoltaic (smOPV) devices, is presented. A benchmark evaluation against experimental results on the accuracy of different exchange and correlation functionals and semi-empirical methods in predicting both reliable ground state equilibrium geometries and electronic absorption spectra is carried out. The benchmark of the geometry optimization level indicated that the best agreement with x-ray data is achieved by using the B3LYP functional. Concerning the optical gap prediction, we found that, among the employed functionals, MPW1K provides the most accurate excitation energies over the entire set of benzofulvenes. Similarly reliable results were also obtained for range-separated hybrid functionals (CAM-B3LYP and wB97XD) and for global hybrid methods incorporating a large amount of non-local exchange (M06-2X and M06-HF). Density functional theory (DFT) hybrids with a moderate (about 20-30%) extent of Hartree-Fock exchange (HFexc) (PBE0, B3LYP and M06) were also found to deliver HOMO-LUMO energy gaps which compare well with the experimental absorption maxima, thus representing a valuable alternative for a prompt and predictive estimation of the optical gap. The possibility of using completely semi-empirical approaches (AM1/ZINDO) is also discussed.

  15. Benchmarking DFT and semi-empirical methods for a reliable and cost-efficient computational screening of benzofulvene derivatives as donor materials for small-molecule organic solar cells

    International Nuclear Information System (INIS)

    Tortorella, Sara; Talamo, Maurizio Mastropasqua; Cardone, Antonio; Pastore, Mariachiara; De Angelis, Filippo

    2016-01-01

    A systematic computational investigation on the optical properties of a group of novel benzofulvene derivatives (Martinelli 2014 Org. Lett. 16 3424–7), proposed as possible donor materials in small molecule organic photovoltaic (smOPV) devices, is presented. A benchmark evaluation against experimental results on the accuracy of different exchange and correlation functionals and semi-empirical methods in predicting both reliable ground state equilibrium geometries and electronic absorption spectra is carried out. The benchmark of the geometry optimization level indicated that the best agreement with x-ray data is achieved by using the B3LYP functional. Concerning the optical gap prediction, we found that, among the employed functionals, MPW1K provides the most accurate excitation energies over the entire set of benzofulvenes. Similarly reliable results were also obtained for range-separated hybrid functionals (CAM-B3LYP and wB97XD) and for global hybrid methods incorporating a large amount of non-local exchange (M06-2X and M06-HF). Density functional theory (DFT) hybrids with a moderate (about 20–30%) extent of Hartree–Fock exchange (HFexc) (PBE0, B3LYP and M06) were also found to deliver HOMO–LUMO energy gaps which compare well with the experimental absorption maxima, thus representing a valuable alternative for a prompt and predictive estimation of the optical gap. The possibility of using completely semi-empirical approaches (AM1/ZINDO) is also discussed. (paper)

  16. Integration of low level and ontology derived features for automatic weapon recognition and identification

    Science.gov (United States)

    Sirakov, Nikolay M.; Suh, Sang; Attardo, Salvatore

    2011-06-01

    This paper presents a further step of a research toward the development of a quick and accurate weapons identification methodology and system. A basic stage of this methodology is the automatic acquisition and updating of weapons ontology as a source of deriving high level weapons information. The present paper outlines the main ideas used to approach the goal. In the next stage, a clustering approach is suggested on the base of hierarchy of concepts. An inherent slot of every node of the proposed ontology is a low level features vector (LLFV), which facilitates the search through the ontology. Part of the LLFV is the information about the object's parts. To partition an object a new approach is presented capable of defining the objects concavities used to mark the end points of weapon parts, considered as convexities. Further an existing matching approach is optimized to determine whether an ontological object matches the objects from an input image. Objects from derived ontological clusters will be considered for the matching process. Image resizing is studied and applied to decrease the runtime of the matching approach and investigate its rotational and scaling invariance. Set of experiments are preformed to validate the theoretical concepts.

  17. Patient-specific cardiovascular progenitor cells derived from integration-free induced pluripotent stem cells for vascular tissue regeneration.

    Science.gov (United States)

    Hu, Jiang; Wang, Yongyu; Jiao, Jiao; Liu, Zhongning; Zhao, Chao; Zhou, Zhou; Zhang, Zhanpeng; Forde, Kaitlynn; Wang, Lunchang; Wang, Jiangang; Baylink, David J; Zhang, Xiao-Bing; Gao, Shaorong; Yang, Bo; Chen, Y Eugene; Ma, Peter X

    2015-12-01

    Tissue-engineered blood vessels (TEBVs) are promising in regenerating a live vascular replacement. However, the vascular cell source is limited, and it is crucial to develop a scaffold that accommodates new type of vascular progenitor cells and facilitates in vivo lineage specification of the cells into functional vascular smooth muscle cells (VSMCs) to regenerate vascular tissue. In the present study, integration-free human induced pluripotent stem cells (hiPSCs) were established from patient peripheral blood mononuclear cells through episomal vector nucleofection of reprogramming factors. The established hiPSCs were then induced into mesoderm-originated cardiovascular progenitor cells (CVPCs) with a highly efficient directed lineage specification method. The derived CVPCs were demonstrated to be able to differentiate into functional VSMCs. Subcutaneous implantation of CVPCs seeded on macroporous nanofibrous poly(l-lactide) scaffolds led to in vivo VSMC lineage specification and matrix deposition inside the scaffolds. In summary, we established integration-free patient-specific hiPSCs from peripheral blood mononuclear cells, derived CVPCs through directed lineage specification, and developed an advanced scaffold for these progenitor cells to further differentiate in vivo into VSMCs and regenerate vascular tissue in a subcutaneous implantation model. This study has established an efficient patient-specific approach towards in vivo regeneration of vascular tissue. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Microcontroller Based Proportional Derivative Plus Conditional Integral Controller for Electro-Mechanical Dual Acting Pulley Continuously Variable Transmission Ratio Control

    International Nuclear Information System (INIS)

    Budianto, A; Tawi, K B; Hussein, M; Supriyo, B; Kob, M S Che; Zulkifli, Mohd Ezlamy; Khairuldean A K; Daraoh, Aishah; Ariyono, S

    2012-01-01

    Electro-Mechanical Dual Acting Pulley (EMDAP) Continuously Variable Transmission (CVT) is a transmission utilized by electro-mechanical actuated system. It has a potential to reduce energy consumption because it only needs power during changing CVT ratio and no power is needed to maintain CVT ratio due to self lock mechanism design. This paper proposed simple proportional derivative plus conditional integral (PDCI) controller to control EMDAP CVT ratio which can be simply implemented on a microcontroller. This proposed controller used Astrom-Hagglund method and Ziegler-Nichols formula to tune PDCI gain. The Proportional Derivative controller is directly activated from the start but Integral controller is only activated when the error value reaches error value setting point. Simulation using Matlab/Simulink software was conducted to evaluate PDCI system performance. The simulation results showed PDCI controller has ability to perform maximum overshoot 0.1%, 0.001 steady state error and 0.5s settling time. For clamping condition, settling time is about 11.46s during changing ratio from 2.0 to 0.7, while for release condition, settling time is about 8.33s during changing ratio from 0.7 to 2.0.

  19. A unified approach to the design of advanced proportional-integral-derivative controllers for time-delay processes

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Moonyong [Yeungnam University, Gyeongsan (Korea, Republic of); Vu, Truong Nguyen Luan [University of Technical Education of Ho Chi Minh City, Ho Chi Minh (China)

    2013-03-15

    A unified approach for the design of proportional-integral-derivative (PID) controllers cascaded with first-order lead-lag filters is proposed for various time-delay processes. The proposed controller’s tuning rules are directly derived using the Padé approximation on the basis of internal model control (IMC) for enhanced stability against disturbances. A two-degrees-of-freedom (2DOF) control scheme is employed to cope with both regulatory and servo problems. Simulation is conducted for a broad range of stable, integrating, and unstable processes with time delays. Each simulated controller is tuned to have the same degree of robustness in terms of maximum sensitivity (Ms). The results demonstrate that the proposed controller provides superior disturbance rejection and set-point tracking when compared with recently published PID-type controllers. Controllers’ robustness is investigated through the simultaneous introduction of perturbation uncertainties to all process parameters to obtain worst-case process-model mismatch. The process-model mismatch simulation results demonstrate that the proposed method consistently affords superior robustness.

  20. The economics of renewable electricity market integration. An empirical and model-based analysis of regulatory frameworks and their impacts on the power market

    Energy Technology Data Exchange (ETDEWEB)

    Nicolosi, Marco

    2012-07-01

    As power systems increase in complexity due to higher shares of intermitting RES-E, so increase the requirements for power system modeling. This thesis shows empirically, with examples from Germany and Texas, that the increasing RES-E share strongly affects current power market operation. The markets further create price signals, which lead to system adaptations in the long-run. To get an estimate of the adaptation effects, 'The High Temporal Resolution Electricity Market Analysis Model' (THEA) has been developed. In a first application for the ERCOT market in Texas, particular model attributes are tested and compared to some complexity reducing approaches, i.e. the reduction of temporal resolution and the reduction of operational constraints. In both cases, the results show significant differences compared to the results when the full spectrum of THEA's capabilities is utilized. The ERCOT case study additionally shows that the adaptation to RES-E in an isolated, mainly thermal-based power system is quite severe. Market signals which underline this conclusion are the severely reduced value of wind energy, the increasing curtailment and the strong shift towards peak-oriented generating capacities. The second application of THEA models the German power market with its interconnected markets. This analysis increases the complexity significantly by modeling a well interconnected system, increasing the amount of different RES-E technologies and adding CAES investment options. In order to assess the impact on the different system component's supply, demand and grid infrastructure, specific measures are applied to compare several scenarios. Each scenario represents a policy option, which either reduces or increases the flexibility of the power system. The scenario comparisons capture the effects of a lower RES-E share, a larger baseload capacity fleet, higher interconnector capacities, various RES-E support scheme designs and the capability of RES-E to

  1. Improved Student Reasoning About Carbon-Transforming Processes Through Inquiry-Based Learning Activities Derived from an Empirically Validated Learning Progression

    Science.gov (United States)

    JW, Schramm; Jin, H.; Keeling, EG; Johnson, M.; Shin, HJ

    2017-05-01

    This paper reports on our use of a fine-grained learning progression to assess secondary students' reasoning through carbon-transforming processes (photosynthesis, respiration, biosynthesis). Based on previous studies, we developed a learning progression with four progress variables: explaining mass changes, explaining energy transformations, explaining subsystems, and explaining large-scale systems. For this study, we developed a 2-week teaching module integrating these progress variables. Students were assessed before and after instruction, with the learning progression framework driving data analysis. Our work revealed significant overall learning gains for all students, with the mean post-test person proficiency estimates higher by 0.6 logits than the pre-test proficiency estimates. Further, instructional effects were statistically similar across all grades included in the study (7th-12th) with students in the lowest third of initial proficiency evidencing the largest learning gains. Students showed significant gains in explaining the processes of photosynthesis and respiration and in explaining transformations of mass and energy, areas where prior research has shown that student misconceptions are prevalent. Student gains on items about large-scale systems were higher than with other variables (although absolute proficiency was still lower). Gains across each of the biological processes tested were similar, despite the different levels of emphasis each had in the teaching unit. Together, these results indicate that students can benefit from instruction addressing these processes more explicitly. This requires pedagogical design quite different from that usually practiced with students at this level.

  2. Generating a non-integrating human induced pluripotent stem cell bank from urine-derived cells.

    Directory of Open Access Journals (Sweden)

    Yanting Xue

    Full Text Available Induced pluripotent stem cell (iPS cell holds great potential for applications in regenerative medicine, drug discovery, and disease modeling. We describe here a practical method to generate human iPS cells from urine-derived cells (UCs under feeder-free, virus-free, serum-free condition and without oncogene c-MYC. We showed that this approach could be applied in a large population with different genetic backgrounds. UCs are easily accessible and exhibit high reprogramming efficiency, offering advantages over other cell types used for the purpose of iPS generation. Using the approach described in this study, we have generated 93 iPS cell lines from 20 donors with diverse genetic backgrounds. The non-viral iPS cell bank with these cell lines provides a valuable resource for iPS cells research, facilitating future applications of human iPS cells.

  3. Designing molecular complexes using free-energy derivatives from liquid-state integral equation theory

    International Nuclear Information System (INIS)

    Mrugalla, Florian; Kast, Stefan M

    2016-01-01

    Complex formation between molecules in solution is the key process by which molecular interactions are translated into functional systems. These processes are governed by the binding or free energy of association which depends on both direct molecular interactions and the solvation contribution. A design goal frequently addressed in pharmaceutical sciences is the optimization of chemical properties of the complex partners in the sense of minimizing their binding free energy with respect to a change in chemical structure. Here, we demonstrate that liquid-state theory in the form of the solute–solute equation of the reference interaction site model provides all necessary information for such a task with high efficiency. In particular, computing derivatives of the potential of mean force (PMF), which defines the free-energy surface of complex formation, with respect to potential parameters can be viewed as a means to define a direction in chemical space toward better binders. We illustrate the methodology in the benchmark case of alkali ion binding to the crown ether 18-crown-6 in aqueous solution. In order to examine the validity of the underlying solute–solute theory, we first compare PMFs computed by different approaches, including explicit free-energy molecular dynamics simulations as a reference. Predictions of an optimally binding ion radius based on free-energy derivatives are then shown to yield consistent results for different ion parameter sets and to compare well with earlier, orders-of-magnitude more costly explicit simulation results. This proof-of-principle study, therefore, demonstrates the potential of liquid-state theory for molecular design problems. (paper)

  4. Thirteen years of integrated precipitable water derived by GPS at Mario Zucchelli Station, Antarctica

    Directory of Open Access Journals (Sweden)

    Pierguido Sarti

    2013-06-01

    Full Text Available Since 1998, the Italian Antarctic Programme has been funding space geodetic activities based on the use of episodic and permanent global positioning system (GPS observations. As well as their exploitation in geodynamics, these data can be used to sense the atmosphere and to retrieve and monitor its water vapor content and variations. The surface pressure p and temperature Ts at the GPS tracking sites are necessary to compute the zenith hydrostatic delay (ZHD, and consequently, the precipitable water. At sites where no surface information is recorded, the p and Ts values can be retrieved from, e.g., global numerical weather prediction models. Alternatively, the site-specific ZHD values can be computed by interpolation of the ZHD values provided in a grid model (2.5° × 2.0°. We have processed the data series of the permanent GPS site TNB1 (Mario Zucchelli Station, Antarctica from 1998 to 2010, with the purpose of comparing the use of grid ZHD values as an alternative to the use of real surface records. With these approaches, we estimate almost 7 × 104 hourly values of precipitable water over 13 years, and we find discrepancies that vary between 1.8 (±0.2 mm in summer and 3.3 (±0.5 mm in winter. In addition, the discrepancies of the two solutions show a clear seasonal dependency. Radiosounding measurements were used to derive an independent series of precipitable water. These agree better with the GPS precipitable water derived from real surface data. However, the GPS precipitable water time series is dry biased, as it is ca. 77% of the total moisture measured by the radiosoundings. Both the GPS and radiosounding observations are processed through the most up-to-date strategies, to reduce known systematic errors.

  5. Integration of Fermentation and Organic Synthesis: Studies of Roquefortine C and Biosynthetic Derivatives

    Science.gov (United States)

    Gober, Claire Marie

    Roquefortine C is one of the most ubiquitous indoline alkaloids of fungal origin. It has been isolated from over 30 different species of Penicillium fungi and has garnered attention in recent years for its role as a biosynthetic precursor to the triazaspirocyclic natural products glandicoline B, meleagrin, and oxaline. The triazaspirocyclic motif, which encompasses three nitrogen atoms attached to one quaternary carbon forming a spirocyclic scaffold, is a unique chemical moiety that has been shown to impart a wide array of biological activity, from anti-bacterial activity and antiproliferative activity against cancer cell lines to anti-biofouling against marine organisms. Despite the promise of these compounds in the pharmaceutical and materials industries, few syntheses of triazaspirocycles exist in the literature. The biosynthesis of roquefortine C-derived triazaspirocycles, however, provides inspiration for the synthesis of these compounds, namely through a nitrone-promoted transannular rearrangement. This type of internal rearrangement has never been carried out synthetically and would provide an efficient stereoselective synthesis of triazaspirocycles. This work encompasses efforts towards elucidating the biosynthetic pathway of roquefortine C-derived triazaspirocycles as well as synthetic efforts towards the construction of triazaspirocycles. Chapter 1 will discuss a large-scale fermentation procedure for the production of roquefortine C from Penicillium crustosum. Chapters 2 and 3 explore (through enzymatic and synthetic means, respectively) the formation of the key indoline nitrone moiety required for the proposed transannular rearrangement. Finally, chapter 4 will discuss synthetic efforts towards the synthesis of triazaspirocycles. This work has considerably enhanced our understanding of the roquefortine C biosynthetic pathway and the unique chemistry of this natural product, and our efforts towards the synthesis of triazaspirocycles will facilitate the

  6. Empirical Hamiltonians

    International Nuclear Information System (INIS)

    Peggs, S.; Talman, R.

    1986-08-01

    As proton accelerators get larger, and include more magnets, the conventional tracking programs which simulate them run slower. At the same time, in order to more carefully optimize the higher cost of the accelerators, they must return more accurate results, even in the presence of a longer list of realistic effects, such as magnet errors and misalignments. For these reasons conventional tracking programs continue to be computationally bound, despite the continually increasing computing power available. This limitation is especially severe for a class of problems in which some lattice parameter is slowly varying, when a faithful description is only obtained by tracking for an exceedingly large number of turns. Examples are synchrotron oscillations in which the energy varies slowly with a period of, say, hundreds of turns, or magnet ripple or noise on a comparably slow time scale. In these cases one may with to track for hundreds of periods of the slowly varying parameter. The purpose of this paper is to describe a method, still under development, in which element-by-element tracking around one turn is replaced by a single map, which can be processed far faster. Similar programs have already been written in which successive elements are ''concatenated'' with truncation to linear, sextupole, or octupole order, et cetera, using Lie algebraic techniques to preserve symplecticity. The method described here is rather more empirical than this but, in principle, contains information to all orders and is able to handle resonances in a more straightforward fashion

  7. Multimodal Imaging Nanoparticles Derived from Hyaluronic Acid for Integrated Preoperative and Intraoperative Cancer Imaging

    Directory of Open Access Journals (Sweden)

    William M. Payne

    2017-01-01

    Full Text Available Surgical resection remains the most promising treatment strategy for many types of cancer. Residual malignant tissue after surgery, a consequence in part due to positive margins, contributes to high mortality and disease recurrence. In this study, multimodal contrast agents for integrated preoperative magnetic resonance imaging (MRI and intraoperative fluorescence image-guided surgery (FIGS are developed. Self-assembled multimodal imaging nanoparticles (SAMINs were developed as a mixed micelle formulation using amphiphilic HA polymers functionalized with either GdDTPA for T1 contrast-enhanced MRI or Cy7.5, a near infrared fluorophore. To evaluate the relationship between MR and fluorescence signal from SAMINs, we employed simulated surgical phantoms that are routinely used to evaluate the depth at which near infrared (NIR imaging agents can be detected by FIGS. Finally, imaging agent efficacy was evaluated in a human breast tumor xenograft model in nude mice, which demonstrated contrast in both fluorescence and magnetic resonance imaging.

  8. Integration-deficient lentivectors: an effective strategy to purify and differentiate human embryonic stem cell-derived hepatic progenitors.

    Science.gov (United States)

    Yang, Guanghua; Si-Tayeb, Karim; Corbineau, Sébastien; Vernet, Rémi; Gayon, Régis; Dianat, Noushin; Martinet, Clémence; Clay, Denis; Goulinet-Mainot, Sylvie; Tachdjian, Gérard; Tachdjian, Gérard; Burks, Deborah; Vallier, Ludovic; Bouillé, Pascale; Dubart-Kupperschmitt, Anne; Weber, Anne

    2013-07-19

    Human pluripotent stem cells (hPSCs) hold great promise for applications in regenerative medicine. However, the safety of cell therapy using differentiated hPSC derivatives must be improved through methods that will permit the transplantation of homogenous populations of a specific cell type. To date, purification of progenitors and mature cells generated from either embryonic or induced pluripotent stem cells remains challenging with use of conventional methods. We used lentivectors encoding green fluorescent protein (GFP) driven by the liver-specific apoliprotein A-II (APOA-II) promoter to purify human hepatic progenitors. We evaluated both integrating and integration-defective lentivectors in combination with an HIV integrase inhibitor. A human embryonic stem cell line was differentiated into hepatic progenitors using a chemically defined protocol. Subsequently, cells were transduced and sorted at day 16 of differentiation to obtain a cell population enriched in hepatic progenitor cells. After sorting, more than 99% of these APOA-II-GFP-positive cells expressed hepatoblast markers such as α-fetoprotein and cytokeratin 19. When further cultured for 16 days, these cells underwent differentiation into more mature cells and exhibited hepatocyte properties such as albumin secretion. Moreover, they were devoid of vector DNA integration. We have developed an effective strategy to purify human hepatic cells from cultures of differentiating hPSCs, producing a novel tool that could be used not only for cell therapy but also for in vitro applications such as drug screening. The present strategy should also be suitable for the purification of a broad range of cell types derived from either pluripotent or adult stem cells.

  9. Dual Binding Site and Selective Acetylcholinesterase Inhibitors Derived from Integrated Pharmacophore Models and Sequential Virtual Screening

    Directory of Open Access Journals (Sweden)

    Shikhar Gupta

    2014-01-01

    Full Text Available In this study, we have employed in silico methodology combining double pharmacophore based screening, molecular docking, and ADME/T filtering to identify dual binding site acetylcholinesterase inhibitors that can preferentially inhibit acetylcholinesterase and simultaneously inhibit the butyrylcholinesterase also but in the lesser extent than acetylcholinesterase. 3D-pharmacophore models of AChE and BuChE enzyme inhibitors have been developed from xanthostigmine derivatives through HypoGen and validated using test set, Fischer’s randomization technique. The best acetylcholinesterase and butyrylcholinesterase inhibitors pharmacophore hypotheses Hypo1_A and Hypo1_B, with high correlation coefficient of 0.96 and 0.94, respectively, were used as 3D query for screening the Zinc database. The screened hits were then subjected to the ADME/T and molecular docking study to prioritise the compounds. Finally, 18 compounds were identified as potential leads against AChE enzyme, showing good predicted activities and promising ADME/T properties.

  10. Starch derivative-based superabsorbent with integration of water-retaining and controlled-release fertilizers.

    Science.gov (United States)

    Zhong, Kang; Lin, Zuan-Tao; Zheng, Xi-Liang; Jiang, Gang-Biao; Fang, Yu-Sheng; Mao, Xiao-Yun; Liao, Zong-Wen

    2013-02-15

    Phosphate rock (PHR), a traditional fertilizer, is abundant, but is hard to be utilized by plants. To improve the utilization of PHR, and to integrate water-retaining and controlled-release fertilizers, an agricultural superabsorbent polymer based on sulfonated corn starch/poly (acrylic acid) embedding phosphate rock (SCS/PAA/PHR) was prepared. PHR can be suspended and well-dispersed in SCS/PAA by sulfonated corn starch (SCS). PHR and KOH were mixed in acrylic acid solution to provide phosphorus (P) and potassium (K) nutrients, respectively. Impacts on water absorption capacity of the superabsorbent were investigated. The maximum swelling capacity in distilled water or 0.9 wt.% (weight percent) NaCl solution reached 498 g g(-1) and 65 g g(-1) (water/prepared dry superabsorbent) respectively. Moreover, release behaviours of P and K in SCS/PAA/PHR were also investigated. The results showed that SCS/PAA/PHR possessed excellent sustained-release property of plant nutrient, and the SCS/PAA could improve the P release greatly. Besides, the XPS analysis was employed to study the relationship between PHR and superabsorbent polymer. Copyright © 2012 Elsevier Ltd. All rights reserved.

  11. A unified approach for proportional-integral-derivative controller design for time delay processes

    International Nuclear Information System (INIS)

    Shamsuzzoha, Mohammad

    2015-01-01

    An analytical design method for PI/PID controller tuning is proposed for several types of processes with time delay. A single tuning formula gives enhanced disturbance rejection performance. The design method is based on the IMC approach, which has a single tuning parameter to adjust the performance and robustness of the controller. A simple tuning formula gives consistently better performance as compared to several well-known methods at the same degree of robustness for stable and integrating process. The performance of the unstable process has been compared with other recently published methods which also show significant improvement in the proposed method. Furthermore, the robustness of the controller is investigated by inserting a perturbation uncertainty in all parameters simultaneously, again showing comparable results with other methods. An analysis has been performed for the uncertainty margin in the different process parameters for the robust controller design. It gives the guidelines of the M s setting for the PI controller design based on the process parameters uncertainty. For the selection of the closed-loop time constant, (τ c ), a guideline is provided over a broad range of θ/τ ratios on the basis of the peak of maximum uncertainty (M s ). A comparison of the IAE has been conducted for the wide range of θ/τ ratio for the first order time delay process. The proposed method shows minimum IAE in compared to SIMC, while Lee et al. shows poor disturbance rejection in the lag dominant process. In the simulation study, the controllers were tuned to have the same degree of robustness by measuring the M s , to obtain a reasonable comparison

  12. Ensemble averaged coherent state path integral for disordered bosons with a repulsive interaction (Derivation of mean field equations)

    International Nuclear Information System (INIS)

    Mieck, B.

    2007-01-01

    We consider bosonic atoms with a repulsive contact interaction in a trap potential for a Bose-Einstein condensation (BEC) and additionally include a random potential. The ensemble averages for two models of static (I) and dynamic (II) disorder are performed and investigated in parallel. The bosonic many body systems of the two disorder models are represented by coherent state path integrals on the Keldysh time contour which allow exact ensemble averages for zero and finite temperatures. These ensemble averages of coherent state path integrals therefore present alternatives to replica field theories or super-symmetric averaging techniques. Hubbard-Stratonovich transformations (HST) lead to two corresponding self-energies for the hermitian repulsive interaction and for the non-hermitian disorder-interaction. The self-energy of the repulsive interaction is absorbed by a shift into the disorder-self-energy which comprises as an element of a larger symplectic Lie algebra sp(4M) the self-energy of the repulsive interaction as a subalgebra (which is equivalent to the direct product of M x sp(2); 'M' is the number of discrete time intervals of the disorder-self-energy in the generating function). After removal of the remaining Gaussian integral for the self-energy of the repulsive interaction, the first order variations of the coherent state path integrals result in the exact mean field or saddle point equations, solely depending on the disorder-self-energy matrix. These equations can be solved by continued fractions and are reminiscent to the 'Nambu-Gorkov' Green function formalism in superconductivity because anomalous terms or pair condensates of the bosonic atoms are also included into the selfenergies. The derived mean field equations of the models with static (I) and dynamic (II) disorder are particularly applicable for BEC in d=3 spatial dimensions because of the singularity of the density of states at vanishing wavevector. However, one usually starts out from

  13. Integration-free induced pluripotent stem cells derived from a patient with autosomal recessive Alport syndrome (ARAS).

    Science.gov (United States)

    Kuebler, Bernd; Aran, Begoña; Miquel-Serra, Laia; Muñoz, Yolanda; Ars, Elisabet; Bullich, Gemma; Furlano, Monica; Torra, Roser; Marti, Merce; Veiga, Anna; Raya, Angel

    2017-12-01

    A skin biopsy was obtained from a 25-year-old female patient with autosomal recessive Alport syndrome (ARAS) with the homozygous COL4A3 mutation c.345delG, p.(P166Lfs*37). Dermal fibroblasts were derived and reprogrammed by nucleofection with episomal plasmids carrying OCT3/4, SOX2, KLF4 LIN28, L-MYC and p53shRNA. The generated induced Pluripotent Stem Cell (iPSC) clone AS FiPS1 Ep6F-2 was free of genomically integrated reprogramming genes, had the specific homozygous mutation, a stable karyotype, expressed pluripotency markers and generated embryoid bodies which were differentiated towards the three germ layers in vitro. This iPSC line offers a useful resource to study Alport syndrome pathomechanisms and drug testing. Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.

  14. Simulation comparison of proportional integral derivative and fuzzy logic in controlling AC-DC buck boost converter

    Science.gov (United States)

    Faisal, A.; Hasan, S.; Suherman

    2018-03-01

    AC-DC converter is widely used in the commercial industry even for daily purposes. The AC-DC converter is used to convert AC voltage into DC. In order to obtain the desired output voltage, the converter usually has a controllable regulator. This paper discusses buck boost regulator with a power MOSFET as switching component which is adjusted based on the duty cycle of pulse width modulation (PWM). The main problems of the buck boost converter at start up are the high overshoot, the long peak time and rise time. This paper compares the effectiveness of two control techniques: proportional integral derivative (PID) and fuzzy logic control in controlling the buck boost converter through simulations. The results show that the PID is more sensitive to voltage change than fuzzy logic. However, PID generates higher overshoot, long peak time and rise time. On the other hand, fuzzy logic generates no overshoot and shorter rise time.

  15. Refinery Integration of By-Products from Coal-Derived Jet Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Caroline Clifford; Andre Boehman; Chunshan Song; Bruce Miller; Gareth Mitchell

    2008-03-31

    The final report summarizes the accomplishments toward project goals during length of the project. The goal of this project was to integrate coal into a refinery in order to produce coal-based jet fuel, with the major goal to examine the products other than jet fuel. These products are in the gasoline, diesel and fuel oil range and result from coal-based jet fuel production from an Air Force funded program. The main goal of Task 1 was the production of coal-based jet fuel and other products that would need to be utilized in other fuels or for non-fuel sources, using known refining technology. The gasoline, diesel fuel, and fuel oil were tested in other aspects of the project. Light cycle oil (LCO) and refined chemical oil (RCO) were blended, hydrotreated to removed sulfur, and hydrogenated, then fractionated in the original production of jet fuel. Two main approaches, taken during the project period, varied where the fractionation took place, in order to preserve the life of catalysts used, which includes (1) fractionation of the hydrotreated blend to remove sulfur and nitrogen, followed by a hydrogenation step of the lighter fraction, and (2) fractionation of the LCO and RCO before any hydrotreatment. Task 2 involved assessment of the impact of refinery integration of JP-900 production on gasoline and diesel fuel. Fuel properties, ignition characteristics and engine combustion of model fuels and fuel samples from pilot-scale production runs were characterized. The model fuels used to represent the coal-based fuel streams were blended into full-boiling range fuels to simulate the mixing of fuel streams within the refinery to create potential 'finished' fuels. The representative compounds of the coal-based gasoline were cyclohexane and methyl cyclohexane, and for the coal-base diesel fuel they were fluorine and phenanthrene. Both the octane number (ON) of the coal-based gasoline and the cetane number (CN) of the coal-based diesel were low, relative to

  16. Refinery Integration of By-Products from Coal-Derived Jet Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Caroline E. Burgess Clifford; Andre Boehman; Chunshan Song; Bruce Miller; Gareth Mitchell

    2007-03-17

    hydrodesulfurization. Equipment is now in place to begin fuel oil evaluations to assess the quality of coal based fuel oil. Combustion and characterization of the latest fuel oil (the high temperature fraction of RCO from the latest modification) indicates that the fraction is heavier than a No. 6 fuel oil. Combustion efficiency on our research boiler is {approx}63% for the heavy RCO fraction, lower than the combustion performance for previous co-coking fuel oils and No. 6 fuel oil. Emission testing indicates that the coal derived material has more trace metals related to coal than petroleum, as seen in previous runs. An additional coal has been procured and is being processed for the next series of delayed co-coking runs. The co-coking of the runs with the new coal have begun, with the coke yield similar to previous runs, but the gas yield is lower and the liquid yield is higher. Characterization of the products continues. Work continues on characterization of liquids and solids from co-coking of hydrotreated decant oils; liquid yields include more saturated and hydro- aromatics, while the coke quality varies depending on the conditions used. Pitch material is being generated from the heavy fraction of co-coking.

  17. Integrated Warm Gas Multicontaminant Cleanup Technologies for Coal-Derived Syngas

    Energy Technology Data Exchange (ETDEWEB)

    Turk, Brian; Gupta, Raghubir; Sharma, Pradeepkumar; Albritton, Johnny; Jamal, Aqil

    2010-09-30

    One of the key obstacles for the introduction of commercial gasification technology for the production of power with Integrated Gasification Combined Cycle (IGCC) plants or the production of value added chemicals, transportation fuels, and hydrogen has been the cost of these systems. This situation is particularly challenging because the United States has ample coal resources available as raw materials and effective use of these raw materials could help us meet our energy and transportation fuel needs while significantly reducing our need to import oil. One component of the cost of these systems that faces strong challenges for continuous improvement is removing the undesirable components present in the syngas. The need to limit the increase in cost of electricity to < 35% for new coal-based power plants which include CO{sub 2} capture and sequestration addresses both the growing social concern for global climate change resulting from the emission of greenhouse gas and in particular CO{sub 2} and the need to control cost increases to power production necessary to meet this social objective. Similar improvements to technologies for trace contaminants are getting similar pressure to reduce environmental emissions and reduce production costs for the syngas to enable production of chemicals from coal that is cost competitive with oil and natural gas. RTI, with DOE/NETL support, has been developing sorbent technologies that enable capture of trace contaminants and CO{sub 2} at temperatures above 400 °F that achieve better capture performance, lower costs and higher thermal efficiency. This report describes the specific work of sorbent development for mercury (Hg), arsenic (As), selenium (Se), cadmium (Cd), and phosphorous (P) and CO{sub 2} removal. Because the typical concentrations of Hg, As, Se, Cd, and P are less than 10 ppmv, the focus has been on single-use sorbents with sufficient capacity to ensure replacement costs are cost effective. The research in this

  18. Empirical microeconomics action functionals

    Science.gov (United States)

    Baaquie, Belal E.; Du, Xin; Tanputraman, Winson

    2015-06-01

    A statistical generalization of microeconomics has been made in Baaquie (2013), where the market price of every traded commodity, at each instant of time, is considered to be an independent random variable. The dynamics of commodity market prices is modeled by an action functional-and the focus of this paper is to empirically determine the action functionals for different commodities. The correlation functions of the model are defined using a Feynman path integral. The model is calibrated using the unequal time correlation of the market commodity prices as well as their cubic and quartic moments using a perturbation expansion. The consistency of the perturbation expansion is verified by a numerical evaluation of the path integral. Nine commodities drawn from the energy, metal and grain sectors are studied and their market behavior is described by the model to an accuracy of over 90% using only six parameters. The paper empirically establishes the existence of the action functional for commodity prices that was postulated to exist in Baaquie (2013).

  19. Integrated Foreign Exchange Risk Management: The Role of Import in Medium-Sized, Manufacturing Firms

    DEFF Research Database (Denmark)

    Aabo, Tom; Høg, Esben; Kuhn, Jochen

    2010-01-01

    Empirical research has focused on export as a proxy for exchange rate exposure and the use of foreign exchange derivatives as an instrument to deal with this exposure. This empirical study applies an integrated foreign exchange risk management approach with a particular focus on the role of impor...

  20. Muslims in their European societies of settlement : A comparative agenda for empirical research on socio-cultural integration across countries and groups

    NARCIS (Netherlands)

    Statham, P.; Tillie, J.

    2016-01-01

    Islam has become the key site for demarcating boundaries between majority populations and individuals of immigrant origin across Europe. This article outlines a research agenda on the socio-cultural integration of Muslims in their Western European societies of settlement. Integration issues with

  1. Importance of kelp-derived organic carbon to the scallop Chlamys farreri in an integrated multi-trophic aquaculture system

    Science.gov (United States)

    Xu, Qiang; Gao, Fei; Yang, Hongsheng

    2016-03-01

    Bivalves and seaweeds are important cleaners that are widely used in integrated multi-trophic aquaculture (IMTA) systems. A beneficial relationship between seaweed and bivalve in the seaweed-based IMTA system has been confirmed, but the trophic importance of seaweed-derived particulate organic materials to the co-cultured bivalve is still unclear. We evaluated the trophic importance of the kelp Saccharina japonica to the co-cultured scallop Chlamys farreri in a typical IMTA farm in Sungo Bay (Weihai, North China). The dynamics of detritus carbon in the water were monitored during the culturing period. The proportion of kelp-derived organic matter in the diet of the co-cultured scallop was assessed via the stable carbon isotope method. Results showed that the detritus carbon in the water ranged from 75.52 to 265.19 μg/L, which was 25.6% to 73.8% of total particulate organic carbon (TPOC) during the study period. The amount of detritus carbon and its proportion in the TPOC changed throughout the culture cycle of the kelp. Stable carbon isotope analysis showed that the cultured scallop obtained 14.1% to 42.8% of its tissue carbon from the kelp, and that the percentages were closely correlated with the proportion of detritus carbon in the water ( F =0.993, P= 0.003). Evaluation showed that for 17 000 tons (wet weight) of annual scallop production, the kelp contributed about 139.3 tons of carbon (535.8 tons of dry mass). This confirms that cultured kelp plays a similar trophic role in IMTA systems as it does in a natural kelp bed. It is a major contributor to the detritus pool and supplies a vital food source to filter-feeding scallops in the IMTA system, especially during winter and early spring when phytoplankton are scarce.

  2. An integrated appraisal of energy recovery options in the United Kingdom using solid recovered fuel derived from municipal solid waste.

    Science.gov (United States)

    Garg, A; Smith, R; Hill, D; Longhurst, P J; Pollard, S J T; Simms, N J

    2009-08-01

    This paper reports an integrated appraisal of options for utilising solid recovered fuels (SRF) (derived from municipal solid waste, MSW) in energy intensive industries within the United Kingdom (UK). Four potential co-combustion scenarios have been identified following discussions with industry stakeholders. These scenarios have been evaluated using (a) an existing energy and mass flow framework model, (b) a semi-quantitative risk analysis, (c) an environmental assessment and (d) a financial assessment. A summary of results from these evaluations for the four different scenarios is presented. For the given ranges of assumptions; SRF co-combustion with coal in cement kilns was found to be the optimal scenario followed by co-combustion of SRF in coal-fired power plants. The biogenic fraction in SRF (ca. 70%) reduces greenhouse gas (GHG) emissions significantly ( approximately 2500 g CO(2) eqvt./kg DS SRF in co-fired cement kilns and approximately 1500 g CO(2) eqvt./kg DS SRF in co-fired power plants). Potential reductions in electricity or heat production occurred through using a lower calorific value (CV) fuel. This could be compensated for by savings in fuel costs (from SRF having a gate fee) and grants aimed at reducing GHG emission to encourage the use of fuels with high biomass fractions. Total revenues generated from coal-fired power plants appear to be the highest ( 95 pounds/t SRF) from the four scenarios. However overall, cement kilns appear to be the best option due to the low technological risks, environmental emissions and fuel cost. Additionally, cement kiln operators have good experience of handling waste derived fuels. The scenarios involving co-combustion of SRF with MSW and biomass were less favourable due to higher environmental risks and technical issues.

  3. An integrated appraisal of energy recovery options in the United Kingdom using solid recovered fuel derived from municipal solid waste

    International Nuclear Information System (INIS)

    Garg, A.; Smith, R.; Hill, D.; Longhurst, P.J.; Pollard, S.J.T.; Simms, N.J.

    2009-01-01

    This paper reports an integrated appraisal of options for utilising solid recovered fuels (SRF) (derived from municipal solid waste, MSW) in energy intensive industries within the United Kingdom (UK). Four potential co-combustion scenarios have been identified following discussions with industry stakeholders. These scenarios have been evaluated using (a) an existing energy and mass flow framework model, (b) a semi-quantitative risk analysis, (c) an environmental assessment and (d) a financial assessment. A summary of results from these evaluations for the four different scenarios is presented. For the given ranges of assumptions; SRF co-combustion with coal in cement kilns was found to be the optimal scenario followed by co-combustion of SRF in coal-fired power plants. The biogenic fraction in SRF (ca. 70%) reduces greenhouse gas (GHG) emissions significantly (∼2500 g CO 2 eqvt./kg DS SRF in co-fired cement kilns and ∼1500 g CO 2 eqvt./kg DS SRF in co-fired power plants). Potential reductions in electricity or heat production occurred through using a lower calorific value (CV) fuel. This could be compensated for by savings in fuel costs (from SRF having a gate fee) and grants aimed at reducing GHG emission to encourage the use of fuels with high biomass fractions. Total revenues generated from coal-fired power plants appear to be the highest ( Pounds 95/t SRF) from the four scenarios. However overall, cement kilns appear to be the best option due to the low technological risks, environmental emissions and fuel cost. Additionally, cement kiln operators have good experience of handling waste derived fuels. The scenarios involving co-combustion of SRF with MSW and biomass were less favourable due to higher environmental risks and technical issues.

  4. An exploration of knowledge integration problems in interdisciplinary research teams

    NARCIS (Netherlands)

    Bayerl, P.S.; Steinheider, B.

    2009-01-01

    The integration of function-specific expertise into a shared knowledge base is a crucial, but complex process for success in interdisciplinary teams. This paper presents an empirically derived typology of knowledge integration problems and links their occurrence to degree of heterogeneity and

  5. A recurrent human papillomavirus integration site at chromosome region 12q14-q15 in SW756 and SK-v cell lines derived from genital tumors

    International Nuclear Information System (INIS)

    Sastre-Garau, X.; Couturier, J.; Favre, M.; Orth, G.

    1995-01-01

    The SW756 cell line, derived from an invasive cancer of the uterine cervix, harbours integrated human papillomavirus (HPV) 18 DNA sequences which have been located in chromosome band 12q13. By in situ hybridization experiments with tritiated and digoxigenin-labelled HPV18 probes on R-banded chromosomes, we now localize the integrated viral sequences in 12q14-q15. Interestingly, we have previously localized integrated HPV16 sequences in the same chromosomal region in SK-v cells, derived from a pre-invasive vulvar neoplasia. The chromosomal region 12q14-q15 could thus correspond to a preferential site for the integration of HPV DNA in genital tumors. (authors). 29 refs., 2 figs

  6. Hermite-Hadamard Type Integral Inequalities for Functions Whose Second-Order Mixed Derivatives Are Coordinated (s,m-P-Convex

    Directory of Open Access Journals (Sweden)

    Yu-Mei Bai

    2018-01-01

    Full Text Available We establish some new Hermite-Hadamard type integral inequalities for functions whose second-order mixed derivatives are coordinated (s,m-P-convex. An expression form of Hermite-Hadamard type integral inequalities via the beta function and the hypergeometric function is also presented. Our results provide a significant complement to the work of Wu et al. involving the Hermite-Hadamard type inequalities for coordinated (s,m-P-convex functions in an earlier article.

  7. [Quality of buffy-coat-derived platelet concentrates prepared using automated system terumo automated centrifuge and separator integration (TACSI)].

    Science.gov (United States)

    Zebrowska, Agnieszka; Lipska, Alina; Rogowska, Anna; Bujno, Magdalena; Nedzi, Marta; Radziwon, Piotr

    2011-03-01

    Platelet recovery, and viability, and function is strongly dependent on the method of the preparation of platelet concentrate (PC). The glucose consumption, decrease of pH, release of alpha granules during storage in platelet concentrate impair their clinical effectiveness. To compare of the quality of buffy-coat-derieved platelet concentrates prepared using automatic system terumo automated centrifuge and separator integration (TACSI) and stored over 7 days. PCs were prepared from buffy coats using manual method (group I), or automatic system TACSI (group II). Fifteen PCs prepared from the 5 buffy coats each were stored over 7 days in 22-24 degrees C and tested. Samples were taken from the PCs container on days 1 and 7. The following laboratory tests were performed: number of platelets, platelets derived microparticles, CD62P expression, platelet adhesion, pH, glucose, lactate dehydrogenase activity. We have observed higher expression of CD62P in PCs prepared using manual method compared to the PCs produced automatically Platelet recovery was significantly higher in PCs prepared using automatic systems compare to manual method. Compared to manual methods, automatic system for preparation of buffy coats, is more efficient and enable production of platelets concentrates of higher quality.

  8. [Research on fuzzy proportional-integral-derivative control of master-slave minimally invasive operation robot driver].

    Science.gov (United States)

    Zhao, Ximei; Ren, Chengyi; Liu, Hao; Li, Haogyi

    2014-12-01

    Robotic catheter minimally invasive operation requires that the driver control system has the advantages of quick response, strong anti-jamming and real-time tracking of target trajectory. Since the catheter parameters of itself and movement environment and other factors continuously change, when the driver is controlled using traditional proportional-integral-derivative (PID), the controller gain becomes fixed once the PID parameters are set. It can not change with the change of the parameters of the object and environmental disturbance so that its change affects the position tracking accuracy, and may bring a large overshoot endangering patients' vessel. Therefore, this paper adopts fuzzy PID control method to adjust PID gain parameters in the tracking process in order to improve the system anti-interference ability, dynamic performance and tracking accuracy. The simulation results showed that the fuzzy PID control method had a fast tracking performance and a strong robustness. Compared with those of traditional PID control, the feasibility and practicability of fuzzy PID control are verified in a robotic catheter minimally invasive operation.

  9. High performance organic integrated device with ultraviolet photodetective and electroluminescent properties consisting of a charge-transfer-featured naphthalimide derivative

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Hanyu; Wang, Xu; Yu, Junsheng, E-mail: luzhiyun@scu.edu.cn, E-mail: jsyu@uestc.edu.cn [State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Optoelectronic Information, University of Electronic Science and Technology of China, Chengdu 610054 (China); Zhou, Jie; Lu, Zhiyun, E-mail: luzhiyun@scu.edu.cn, E-mail: jsyu@uestc.edu.cn [College of Chemistry, Sichuan University, Chengdu 610064 (China)

    2014-08-11

    A high performance organic integrated device (OID) with ultraviolet photodetective and electroluminescent (EL) properties was fabricated by using a charge-transfer-featured naphthalimide derivative of 6-(3,5-bis-[9-(4-t-butylphenyl)-9H-carbazol-3-yl]-phenoxy)-2- (4-t-butylphenyl)-benzo[de]isoquinoline-1,3-dione (CzPhONI) as the active layer. The results showed that the OID had a high detectivity of 1.5 × 10{sup 11} Jones at −3 V under the UV-350 nm illumination with an intensity of 0.6 mW/cm{sup 2}, and yielded an exciplex EL light emission with a maximum brightness of 1437 cd/m{sup 2}. Based on the energy band diagram, both the charge transfer feature of CzPhONI and matched energy level alignment were responsible for the dual ultraviolet photodetective and EL functions of OID.

  10. Bio-economic farm modelling for integrated assessment of agricultural and environmental policies: towards re-usability and improved empirical validity

    NARCIS (Netherlands)

    Kanellopoulos, A.

    2010-01-01

    Keywords: integrated assessment, environmental policy, agricultural policy, market liberalization, bio-economic model, farming systems, mathematical programming, maximum entropy estimation, data envelopment analysis, agricultural activity, land use, future studies.

    The main objective of

  11. Integration

    DEFF Research Database (Denmark)

    Emerek, Ruth

    2004-01-01

    Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration......Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration...

  12. A Prorating Method for Estimating MMPI-2-RF Scores From MMPI Responses: Examination of Score Fidelity and Illustration of Empirical Utility in the PERSEREC Police Integrity Study Sample.

    Science.gov (United States)

    Tarescavage, Anthony M; Corey, David M; Ben-Porath, Yossef S

    2016-04-01

    The purpose of the current study was to identify Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) correlates of police officer integrity violations and other problem behaviors in an archival database with original MMPI item responses and collateral information regarding integrity violations obtained for 417 male officers. In Study 1, we estimated MMPI-2-RF scores from the MMPI item pool (which includes approximately 80% of the MMPI-2-RF items) in a normative sample, a psychiatric inpatient sample, and a police officer sample, and conducted analyses that demonstrated the comparability of estimated and full scale scores for 41 of the 51 MMPI-2-RF scales. In Study 2, we correlated estimated MMPI-2-RF scores with information about subsequent integrity violations and problem behaviors from the integrity violation data set. Several meaningful associations were obtained, predominately with scales from the emotional, thought, and behavioral dysfunction domains of the MMPI-2-RF. Application of a correction for range restriction yielded substantially improved validity estimates. Finally, we calculated relative risk ratios for the statistically significant findings using cutoffs lower than 65T, which is traditionally used to identify clinically significant elevations, and found several meaningful relative risk ratios. © The Author(s) 2015.

  13. [Integrity].

    Science.gov (United States)

    Gómez Rodríguez, Rafael Ángel

    2014-01-01

    To say that someone possesses integrity is to claim that that person is almost predictable about responses to specific situations, that he or she can prudentially judge and to act correctly. There is a closed interrelationship between integrity and autonomy, and the autonomy rests on the deeper moral claim of all humans to integrity of the person. Integrity has two senses of significance for medical ethic: one sense refers to the integrity of the person in the bodily, psychosocial and intellectual elements; and in the second sense, the integrity is the virtue. Another facet of integrity of the person is la integrity of values we cherish and espouse. The physician must be a person of integrity if the integrity of the patient is to be safeguarded. The autonomy has reduced the violations in the past, but the character and virtues of the physician are the ultimate safeguard of autonomy of patient. A field very important in medicine is the scientific research. It is the character of the investigator that determines the moral quality of research. The problem arises when legitimate self-interests are replaced by selfish, particularly when human subjects are involved. The final safeguard of moral quality of research is the character and conscience of the investigator. Teaching must be relevant in the scientific field, but the most effective way to teach virtue ethics is through the example of the a respected scientist.

  14. Advancing Empirical Scholarship to Further Develop Evaluation Theory and Practice

    Science.gov (United States)

    Christie, Christina A.

    2011-01-01

    Good theory development is grounded in empirical inquiry. In the context of educational evaluation, the development of empirically grounded theory has important benefits for the field and the practitioner. In particular, a shift to empirically derived theory will assist in advancing more systematic and contextually relevant evaluation practice, as…

  15. Integrated cancer therapy combined radiotherapy and immunotherapy. The challenge of using Gc protein-derived macrophage activating factor (GcMAF) as a key molecule

    International Nuclear Information System (INIS)

    Uto, Yoshihiro; Hori, Hitoshi

    2013-01-01

    Radiation oncologists know the conflict between radiotherapy and immunotherapy, but now challenged trails of the integrative cancer therapies combined radiation therapy and various immunoreaction/immune therapies begin. We therefore review the recent results of basic research and clinical trial of the integrated cancer therapies which combined radiotherapy and various immune therapies/immunoreaction, and the challenged studies of combined use of radiotherapy and our developed cancer immunotherapy using serum GcMAF which is human serum containing Gc protein-derived macrophage activating factor (GcMAF). (author)

  16. Identification of climate-resilient integrated nutrient management practices for rice-rice cropping system—an empirical approach to uphold food security

    Science.gov (United States)

    Subash, N.; Gangwar, B.; Singh, Rajbir; Sikka, A. K.

    2015-01-01

    Yield datasets of long-term experiments on integrated nutrient management in rice-rice cropping systems were used to investigate the relationship of variability in rainfall, temperature, and integrated nutrient management (INM) practices in rice-rice cropping system in three different agroecological regions of India. Twelve treatments with different combinations of inorganic (chemical fertilizer) and organic (farmyard manure, green manure, and paddy straw) were compared with farmer's conventional practice. The intraseasonal variations in rice yields are largely driven by rainfall during kharif rice and by temperature during rabi rice. Half of the standard deviation from the average monthly as well as seasonal rainfall during kharif rice and 1 °C increase or decrease from the average maximum and minimum temperature during rabi rice has been taken as the classification of yield groups. The trends in the date of effective onset of monsoon indicate a 36-day delay during the 30-year period at Rajendranagar, which is statistically significant at 95 % confidence level. The mean annual maximum temperature shows an increasing trend in all the study sites. The length of monsoon also showed a shrinking trend in the rate of 40 days during the 30-year study period at Rajendranagar representing a semiarid region. At Bhubaneshwar, the application of 50 % recommended NPK through chemical fertilizers and 50 % N through green manure resulted in an overall average higher increase of 5.1 % in system productivity under both excess and deficit rainfall years and also during the years having seasonal mean maximum temperature ≥35 °C. However, at Jorhat, the application of 50 % recommended NPK through chemical fertilizers and 50 % N through straw resulted in an overall average higher increase of 7.4 % in system productivity, while at Rajendranagar, the application of 75 % NPK through chemical fertilizers and 25 % N through green manusre resulted in an overall average higher increase of

  17. Identification of climate-resilient integrated nutrient management practices for rice-rice cropping system--an empirical approach to uphold food security.

    Science.gov (United States)

    Subash, N; Gangwar, B; Singh, Rajbir; Sikka, A K

    2015-01-01

    Yield datasets of long-term experiments on integrated nutrient management in rice-rice cropping systems were used to investigate the relationship of variability in rainfall, temperature, and integrated nutrient management (INM) practices in rice-rice cropping system in three different agroecological regions of India. Twelve treatments with different combinations of inorganic (chemical fertilizer) and organic (farmyard manure, green manure, and paddy straw) were compared with farmer's conventional practice. The intraseasonal variations in rice yields are largely driven by rainfall during kharif rice and by temperature during rabi rice. Half of the standard deviation from the average monthly as well as seasonal rainfall during kharif rice and 1 °C increase or decrease from the average maximum and minimum temperature during rabi rice has been taken as the classification of yield groups. The trends in the date of effective onset of monsoon indicate a 36-day delay during the 30-year period at Rajendranagar, which is statistically significant at 95 % confidence level. The mean annual maximum temperature shows an increasing trend in all the study sites. The length of monsoon also showed a shrinking trend in the rate of 40 days during the 30-year study period at Rajendranagar representing a semiarid region. At Bhubaneshwar, the application of 50 % recommended NPK through chemical fertilizers and 50 % N through green manure resulted in an overall average higher increase of 5.1 % in system productivity under both excess and deficit rainfall years and also during the years having seasonal mean maximum temperature ≥35 °C. However, at Jorhat, the application of 50 % recommended NPK through chemical fertilizers and 50 % N through straw resulted in an overall average higher increase of 7.4 % in system productivity, while at Rajendranagar, the application of 75 % NPK through chemical fertilizers and 25 % N through green manusre resulted in an overall average higher increase of

  18. Density functional calculations of potential energy surface and charge transfer integrals in molecular triphenylene derivative HAT6

    NARCIS (Netherlands)

    Zbiri, M.; Johnson, M.R.; Kearley, G.J.; Mulder, F.M.

    2009-01-01

    We investigate the effect of structural fluctuations on charge transfer integrals, overlap integrals, and site energies in a system of two stacked molecular 2,3,6,7,10,11-hexakishexyloxytriphenylene (HAT6), which is a model system for conducting devices in organic photocell applications. A density

  19. Volume integral equation for electromagnetic scattering: Rigorous derivation and analysis for a set of multilayered particles with piecewise-smooth boundaries in a passive host medium

    Science.gov (United States)

    Yurkin, Maxim A.; Mishchenko, Michael I.

    2018-04-01

    We present a general derivation of the frequency-domain volume integral equation (VIE) for the electric field inside a nonmagnetic scattering object from the differential Maxwell equations, transmission boundary conditions, radiation condition at infinity, and locally-finite-energy condition. The derivation applies to an arbitrary spatially finite group of particles made of isotropic materials and embedded in a passive host medium, including those with edges, corners, and intersecting internal interfaces. This is a substantially more general type of scatterer than in all previous derivations. We explicitly treat the strong singularity of the integral kernel, but keep the entire discussion accessible to the applied scattering community. We also consider the known results on the existence and uniqueness of VIE solution and conjecture a general sufficient condition for that. Finally, we discuss an alternative way of deriving the VIE for an arbitrary object by means of a continuous transformation of the everywhere smooth refractive-index function into a discontinuous one. Overall, the paper examines and pushes forward the state-of-the-art understanding of various analytical aspects of the VIE.

  20. Is Pakistani Equity Market Integrated to the Equity Markets of Group of Eight (G8 Countries? An Empirical Analysis of Karachi Stock Exchange

    Directory of Open Access Journals (Sweden)

    Syed Muhammad Aamir Shah

    2012-09-01

    Full Text Available This study looks at the dynamic relationship between the Pakistani equity market and equity markets of Group of Eight countries (G8 which includes Canada, France, Germany, Italy, Japan, Russia, UK and USA by using weekly time series data starting from June 2004 to May 2009. Multivariate Co-integration approach by Johnson and Julius (1990 shows there exists no long-term relationship between the G8 and Pakistani equity market. Vector error correction (VECM model suggests that 100% of the lag periods disequilibrium has been corrected in the current period. Pairwise Granger Causality test shows that there exist a unidirectional causality between the equity market of Pakistan and the markets of France, Germany, Italy, Japan and United Kingdom. Impulse response analysis and variance decomposition analysis reveal that most of the shocks in Pakistani equity market are due to its own innovation and behave like exogenous. However, the markets of France, Japan, Germany and United Kingdom are exerting a little pressure on Pakistani equity markets. Therefore, by investing in Karachi Stock Exchange (KSE the fund manager of G8 countries especially Canada, Italy, Russia and USA is capable of getting the advantage of portfolio diversification.

  1. Empirical Test Case Specification

    DEFF Research Database (Denmark)

    Kalyanova, Olena; Heiselberg, Per

    This document includes the empirical specification on the IEA task of evaluation building energy simulation computer programs for the Double Skin Facades (DSF) constructions. There are two approaches involved into this procedure, one is the comparative approach and another is the empirical one. I....... In the comparative approach the outcomes of different software tools are compared, while in the empirical approach the modelling results are compared with the results of experimental test cases....

  2. Murine leukemia virus-derived retroviral vector has differential integration patterns in human cell lines used to produce recombinant factor VIII

    Directory of Open Access Journals (Sweden)

    Marcela Cristina Correa de Freitas

    2014-06-01

    Full Text Available OBJECTIVE: Nowadays recombinant factor VIII is produced in murine cells including in Chinese hamster ovary (CHO and baby hamster kidney cells (BHK. Previous studies, using the murine leukemia virus-derived retroviral vector pMFG-FVIII-P140K, modified two recombinant human cell lines, HepG2 and Hek293 to produce recombinant factor VIII. In order to characterize these cells, the present study aimed to analyze the integration pattern of retroviral vector pMFG-FVIII-P140K.METHODS: This study used ligation-mediated polymerase chain reaction to locate the site of viral vector integration by sequencing polymerase chain reaction products. The sequences were compared to genomic databases to characterize respective clones.RESULTS: The retroviral vector presented different and non-random profiles of integration between cells lines. A preference of integration for chromosomes 19, 17 and 11 was observed for HepG2FVIIIdB/P140K and chromosome 9 for Hek293FVIIIdB/P140K. In genomic regions such as CpG islands and transcription factor binding sites, there was no difference in the integration profiles for both cell lines. Integration in intronic regions of encoding protein genes (RefSeq genes was also observed in both cell lines. Twenty percent of integrations occurred at fragile sites in the genome of the HepG2 cell line and 17% in Hek293.CONCLUSION: The results suggest that the cell type can affect the profile of chromosomal integration of the retroviral vector used; these differences may interfere in the level of expression of recombinant proteins.

  3. Integration of Stem Cell to Chondrocyte-Derived Cartilage Matrix in Healthy and Osteoarthritic States in the Presence of Hydroxyapatite Nanoparticles.

    Directory of Open Access Journals (Sweden)

    Rupak Dua

    Full Text Available We investigated the effectiveness of integrating tissue engineered cartilage derived from human bone marrow derived stem cells (HBMSCs to healthy as well as osteoarthritic cartilage mimics using hydroxyapatite (HA nanoparticles immersed within a hydrogel substrate. Healthy and diseased engineered cartilage from human chondrocytes (cultured in agar gels were integrated with human bone marrow stem cell (HBMSC-derived cartilaginous engineered matrix with and without HA, and evaluated after 28 days of growth. HBMSCs were seeded within photopolymerizable poly (ethylene glycol diacrylate (PEGDA hydrogels. In addition, we also conducted a preliminary in vivo evaluation of cartilage repair in rabbit knee chondral defects treated with subchondral bone microfracture and cell-free PEGDA with and without HA. Under in vitro conditions, the interfacial shear strength between tissue engineered cartilage derived from HBMSCs and osteoarthritic chondrocytes was significantly higher (p < 0.05 when HA nanoparticles were incorporated within the HBMSC culture system. Histological evidence confirmed a distinct spatial transition zone, rich in calcium phosphate deposits. Assessment of explanted rabbit knees by histology demonstrated that cellularity within the repair tissues that had filled the defects were of significantly higher number (p < 0.05 when HA was used. HA nanoparticles play an important role in treating chondral defects when osteoarthritis is a co-morbidity. We speculate that the calcified layer formation at the interface in the osteoarthritic environment in the presence of HA is likely to have attributed to higher interfacial strength found in vitro. From an in vivo standpoint, the presence of HA promoted cellularity in the tissues that subsequently filled the chondral defects. This higher presence of cells can be considered important in the context of accelerating long-term cartilage remodeling. We conclude that HA nanoparticles play an important role in

  4. Use of derivative instruments to integrate renewable energies into the electricity market; Einsatz derivativer Instrumente zur Integration erneuerbarer Energien in den Strommarkt

    Energy Technology Data Exchange (ETDEWEB)

    Hartmann, Kilian [Hochschule Aschaffenburg (Germany). Fakultaet fuer Ingenieurwissenschaften; Nelles, Michael [Rostock Univ. (Germany). Agrar- und Umweltwissenschaftliche Fakultaet; Candra, Dodiek Ika

    2017-08-01

    The implementation of renewable energies to the electricity market is inefficient and expensive with current measures. Further these measures are prejudicial for the existing energy-only-market. The combination of fluctuating and controllable renewable powers in virtual power plants enables the marketing of this power as a derivate on the future market. Thus would relieve the spot market and stabilize pricing on both markets. Subsequently the renewable energy obligation will reduce and renewable energies could be marketed as secured power.

  5. M-theoretic derivations of 4d-2d dualities: from a geometric Langlands duality for surfaces, to the AGT correspondence, to integrable systems

    Science.gov (United States)

    Tan, Meng-Chwan

    2013-07-01

    In part I, we extend our analysis in [arXiv:0807.1107], and show that a mathematically conjectured geometric Langlands duality for complex surfaces in [1], and its generalizations — which relate some cohomology of the moduli space of certain ("ramified") G-instantons to the integrable representations of the Langlands dual of certain affine (sub) G-algebras, where G is any compact Lie group — can be derived, purely physically, from the principle that the spacetime BPS spectra of string-dual M-theory compactifications ought to be equivalent. In part II, to the setup in part I, we introduce Omega-deformation via fluxbranes and add half-BPS boundary defects via M9-branes, and show that the celebrated AGT correspondence in [2, 3], and its generalizations — which essentially relate, among other things, some equivariant cohomology of the moduli space of certain ("ramified") G-instantons to the integrable representations of the Langlands dual of certain affine -algebras — can likewise be derived from the principle that the spacetime BPS spectra of string-dual M-theory compactifications ought to be equivalent. In part III, we consider various limits of our setup in part II, and connect our story to chiral fermions and integrable systems. Among other things, we derive the NekrasovOkounkov conjecture in [4] — which relates the topological string limit of the dual Nekrasov partition function for pure G to the integrable representations of the Langlands dual of an affine G-algebra — and also demonstrate that the Nekrasov-Shatashvili limit of the "fullyramified" Nekrasov instanton partition function for pure G is a simultaneous eigenfunction of the quantum Toda Hamiltonians associated with the Langlands dual of an affine G-algebra. Via the case with matter, we also make contact with Hitchin systems and the "ramified" geometric Langlands correspondence for curves.

  6. An Empirical Taxonomy of Crowdfunding Intermediaries

    OpenAIRE

    Haas, Philipp; Blohm, Ivo; Leimeister, Jan Marco

    2014-01-01

    Due to the recent popularity of crowdfunding, a broad magnitude of crowdfunding intermediaries has emerged, while research on crowdfunding intermediaries has been largely neglected. As a consequence, existing classifications of crowdfunding intermediaries are conceptual, lack theoretical grounding, and are not empirically validated. Thus, we develop an empirical taxonomy of crowdfunding intermediaries, which is grounded in the theories of two-sided markets and financial intermediation. Integr...

  7. Empirically Testing Thematic Analysis (ETTA)

    DEFF Research Database (Denmark)

    Gildberg, Frederik Alkier; Bradley, Stephen K.; Tingleff, Elllen B.

    2015-01-01

    Text analysis is not a question of a right or wrong way to go about it, but a question of different traditions. These tend to not only give answers to how to conduct an analysis, but also to provide the answer as to why it is conducted in the way that it is. The problem however may be that the li...... for themselves. The advantage of utilizing the presented analytic approach is argued to be the integral empirical testing, which should assure systematic development, interpretation and analysis of the source textual material....... between tradition and tool is unclear. The main objective of this article is therefore to present Empirical Testing Thematic Analysis, a step by step approach to thematic text analysis; discussing strengths and weaknesses, so that others might assess its potential as an approach that they might utilize/develop...

  8. Integrated report on the toxicological mitigation of coal liquids by hydrotreatment and other processes. [Petroleum and coal-derived products

    Energy Technology Data Exchange (ETDEWEB)

    Guerin, M.R.; Griest, W.H.; Ho, C.H.; Smith, L.H.; Witschi, H.P.

    1986-06-01

    Research here on the toxicological properties of coal-derived liquids focuses on characterizing the refining process and refined products. Principle attention is given to the potential tumorigenicity of coal-derived fuels and to the identification of means to further reduce tumorigenicity should this be found necessary. Hydrotreatment is studied most extensively because it will be almost certainly required to produce commercial products and because it is likely to also greatly reduce tumorigenic activity relative to that of crude coal-liquid feedstocks. This report presents the results of a lifetime C3H mouse skin tumorigenicity assay of an H-Coal series of oils and considers the relationships between tumorigenicity, chemistry, and processing. Lifetime assay results are reported for an H-Coal syncrude mode light oil/heavy oil blend, a low severity hydrotreatment product, a high severity hydrotreatment product, a naphtha reformate, a heating oil, a petroleum-derived reformate, and a petroleum derived heating oil. Data are compared with those for an earlier study of an SRC-II blend and products of its hydrotreatment. Adequate data are presented to allow an independent qualitative assessment of the conclusions while statistical evaluation of the data is being completed. The report also documents the physical and chemical properties of the oils tested. 33 refs., 14 figs., 53 tabs.

  9. Derivations of the solid angle subtended at a point by first- and second-order surfaces and volumes as a function of elliptic integrals

    International Nuclear Information System (INIS)

    Cramer, S.N.

    1999-01-01

    An analytical study of the solid angle subtended at a point by objects of first and second algebraic order has been made. It is shown that the derived solid angle for all such objects is in the form of a general elliptic integral, which can be written as a linear combination of elliptic integrals of the first and third kind and elementary functions. Many common surfaces and volumes have been investigated, including the conic sections and their volumes of revolution. The principal feature of the study is the manipulation of solid-angle equations into integral forms that can be matched with those found in handbook tables. These integrals are amenable to computer special function library routine analysis requiring no direct interaction with elliptic integrals by the user. The general case requires the solution of a fourth-order equation before specific solid-angle formulations can be made, but for many common geometric objects this equation can be solved by elementary means. Methods for the testing and application of solid-angle equations with Monte Carlo rejection and estimation techniques are presented. Approximate and degenerate forms of the equations are shown, and methods for the evaluation of the solid angle of a torus are outlined

  10. A GIS-derived integrated moisture index to predict forest composition and productivity of Ohio forests (U.S.A.)

    Science.gov (United States)

    Louis R. Iverson; Martin E. Dale; Charles T. Scott; Anantha Prasad; Anantha Prasad

    1997-01-01

    A geographic information system (GIS) approach was used in conjunction with forest-plot data to develop an integrated moisture index (IMI), which was then used to predict forest productivity (site index) and species composition for forests in Ohio. In this region, typical of eastern hardwoods across the Midwest and southern Appalachians, topographic aspect and position...

  11. Bone Marrow?Derived Mesenchymal Stem Cells Enhance Bacterial Clearance and Preserve Bioprosthetic Integrity in a Model of Mesh Infection

    OpenAIRE

    Criman, Erik T.; Kurata, Wendy E.; Matsumoto, Karen W.; Aubin, Harry T.; Campbell, Carmen E.; Pierce, Lisa M.

    2016-01-01

    Background: The reported incidence of mesh infection in contaminated operative fields is as high as 30% regardless of the material used. Recently, mesenchymal stem cells (MSCs) have been shown to possess favorable immunomodulatory properties and improve tissue incorporation when seeded onto bioprosthetics. The aim of this study was to evaluate whether seeding noncrosslinked bovine pericardium (Veritas Collagen Matrix) with allogeneic bone marrow?derived MSCs improves infection resistance in v...

  12. Semi-empiric model of an air cooled cabinet air conditioner for the dynamic analysis of the building and acclimation systems integrated behaviour; Modelo semi-empirico de condicionador de gabinete resfriado a ar para analise dinamica do comportamento integrado de edificacoes e sistemas de climatizacao

    Energy Technology Data Exchange (ETDEWEB)

    Correa, Jorge E. [Para Univ., Belem (Brazil). Dept. de Engenharia Mecanica]. E-mail: jecorrea@amazon.com.br; Melo, Claudio. E-mail: melo@nrva.ufsc.br; Negrao, Cezar O. R. E-mail: negrao@energia.damec.cefetpr.br

    2000-07-01

    This work presents a semi-empirical model for a air cooled case air conditioner. This model is to be inserted in the EPS-r program (Environmental System Performance - research version) allowing the dynamic analysis of the integrated behaviour of buildings and acclimation systems using this equipment. Results obtained from simulations under the operation conditions existing in Brazil are analysed.

  13. Lymphoblast-derived integration-free ISRM-CON9 iPS cell line from a 75 year old female

    Directory of Open Access Journals (Sweden)

    Soraia Martins

    2018-01-01

    Full Text Available Human lymphoblast cells were used to generate integration-free induced pluripotent stem cells (iPSCs employing episomal-based plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and L-MYC. The derived iPSCs were defined as pluripotent based on (i expression of pluripotency-associated markers, (ii embryoid body-based differentiation into cell types representative of the three germ layers and (iii the similarity between the transcriptomes of the iPSC line and the human embryonic stem cell line H1 with a Pearson correlation of 0.95.

  14. Internally-directed cognition and mindfulness:An integrative perspective derived from reactive versus predictive control systems theory

    Directory of Open Access Journals (Sweden)

    Mattie eTops

    2014-05-01

    Full Text Available In the present paper we will apply the Predictive And Reactive Control Systems (PARCS theory as a framework that integrates competing theories of neural substrates of awareness by describing the default mode network (DMN and anterior insula (AI as parts of two different behavioral and homeostatic control systems. The DMN, a network that becomes active at rest when there is no external stimulation or task to perform, has been implicated in self-reflective awareness and prospection. By contrast, the AI is associated with awareness and task-related attention. This has led to competing theories stressing the role of the DMN in self-awareness versus the role of interoceptive and emotional information integration in the AI in awareness of the emotional moment. In PARCS, the respective functions of the DMN and AI in a specific control system explains their association with different qualities of awareness, and how mental states can shift from one state (e.g., prospective self-reflection to the other (e.g., awareness of the emotional moment depending on the relative dominance of control systems. These shifts between reactive and predictive control are part of processes that enable the intake of novel information, integration of this novel information within existing knowledge structures, and the creation of a continuous personal context in which novel information can be integrated and understood. As such, PARCS can explain key characteristics of mental states, such as their temporal and spatial focus (e.g., a focus on the here and now vs. the future; a 1st person vs. a 3rd person perspective. PARCS further relates mental states to brain states and functions, such as activation of the DMN or hemispheric asymmetry in frontal cortical functions. Together, PARCS deepens the understanding of a broad range of mental states, including mindfulness, mind wandering, rumination, autobiographical memory, imagery, and the experience of self.

  15. 'Integration'

    DEFF Research Database (Denmark)

    Olwig, Karen Fog

    2011-01-01

    , while the countries have adopted disparate policies and ideologies, differences in the actual treatment and attitudes towards immigrants and refugees in everyday life are less clear, due to parallel integration programmes based on strong similarities in the welfare systems and in cultural notions...... of equality in the three societies. Finally, it shows that family relations play a central role in immigrants’ and refugees’ establishment of a new life in the receiving societies, even though the welfare society takes on many of the social and economic functions of the family....

  16. Life Writing After Empire

    DEFF Research Database (Denmark)

    A watershed moment of the twentieth century, the end of empire saw upheavals to global power structures and national identities. However, decolonisation profoundly affected individual subjectivities too. Life Writing After Empire examines how people around the globe have made sense of the post...... in order to understand how individual life writing reflects broader societal changes. From far-flung corners of the former British Empire, people have turned to life writing to manage painful or nostalgic memories, as well as to think about the past and future of the nation anew through the personal...

  17. Theological reflections on empire

    Directory of Open Access Journals (Sweden)

    Allan A. Boesak

    2009-11-01

    Full Text Available Since the meeting of the World Alliance of Reformed Churches in Accra, Ghana (2004, and the adoption of the Accra Declaration, a debate has been raging in the churches about globalisation, socio-economic justice, ecological responsibility, political and cultural domination and globalised war. Central to this debate is the concept of empire and the way the United States is increasingly becoming its embodiment. Is the United States a global empire? This article argues that the United States has indeed become the expression of a modern empire and that this reality has considerable consequences, not just for global economics and politics but for theological refl ection as well.

  18. Classification of Marital Relationships: An Empirical Approach.

    Science.gov (United States)

    Snyder, Douglas K.; Smith, Gregory T.

    1986-01-01

    Derives an empirically based classification system of marital relationships, employing a multidimensional self-report measure of marital interaction. Spouses' profiles on the Marital Satisfaction Inventory for samples of clinic and nonclinic couples were subjected to cluster analysis, resulting in separate five-group typologies for husbands and…

  19. Mitigation of biofilm formation on corrugated cardboard fresh produce packaging surfaces using a novel thiazolidinedione derivative integrated in acrylic emulsion polymers

    Directory of Open Access Journals (Sweden)

    Michael eBrandwein

    2016-02-01

    Full Text Available Various surfaces associated with the storage and packing of food are known to harbor distinct bacterial pathogens. Conspicuously absent among the plethora of studies implicating food packaging materials and machinery is the study of corrugated cardboard packaging, the worldwide medium for transporting fresh produce. In this study, we observed the microbial communities of three different store-bought fruits and vegetables, along with their analogue cardboard packaging using high throughput sequencing technology. We further developed an anti-biofilm polymer meant to coat corrugated cardboard surfaces and mediate bacterial biofilm growth on said surfaces. Integration of a novel thiazolidinedione derivative into the acrylic emulsion polymers was assessed using Energy Dispersive X-ray Spectrometry analysis and surface topography was visualized and quantified on corrugated cardboard surfaces. Biofilm growth was measured using q-PCR targeting the gene encoding 16s rRNA. Additionally, architectural structure of the biofilm was observed using SEM. The uniform integration of the thiazolidinedione derivative TZD-6 was confirmed, and it was determined via q-PCR to reduce biofilm growth by ~80% on tested surfaces. A novel and effective method for reducing microbial load and preventing contamination on food packaging is thereby proposed.

  20. Mitigation of Biofilm Formation on Corrugated Cardboard Fresh Produce Packaging Surfaces Using a Novel Thiazolidinedione Derivative Integrated in Acrylic Emulsion Polymers.

    Science.gov (United States)

    Brandwein, Michael; Al-Quntar, Abed; Goldberg, Hila; Mosheyev, Gregory; Goffer, Moshe; Marin-Iniesta, Fulgencio; López-Gómez, Antonio; Steinberg, Doron

    2016-01-01

    Various surfaces associated with the storage and packing of food are known to harbor distinct bacterial pathogens. Conspicuously absent among the plethora of studies implicating food packaging materials and machinery is the study of corrugated cardboard packaging, the worldwide medium for transporting fresh produce. In this study, we observed the microbial communities of three different store-bought fruits and vegetables, along with their analog cardboard packaging using high throughput sequencing technology. We further developed an anti-biofilm polymer meant to coat corrugated cardboard surfaces and mediate bacterial biofilm growth on said surfaces. Integration of a novel thiazolidinedione derivative into the acrylic emulsion polymers was assessed using Energy Dispersive X-ray Spectrometry (EDS) analysis and surface topography was visualized and quantified on corrugated cardboard surfaces. Biofilm growth was measured using q-PCR targeting the gene encoding 16s rRNA. Additionally, architectural structure of the biofilm was observed using SEM. The uniform integration of the thiazolidinedione derivative TZD-6 was confirmed, and it was determined via q-PCR to reduce biofilm growth by ~80% on tested surfaces. A novel and effective method for reducing microbial load and preventing contamination on food packaging is thereby proposed.

  1. Empirical Evidence from Kenya

    African Journals Online (AJOL)

    FIRST LADY

    2011-01-18

    Jan 18, 2011 ... Empirical results reveal that consumption of sugar in. Kenya varies ... experiences in trade in different regions of the world. Some studies ... To assess the relationship between domestic sugar retail prices and sugar sales in ...

  2. Integrated Analysis of Contractile Kinetics, Force Generation, and Electrical Activity in Single Human Stem Cell-Derived Cardiomyocytes

    Directory of Open Access Journals (Sweden)

    Jan David Kijlstra

    2015-12-01

    Full Text Available The quantitative analysis of cardiomyocyte function is essential for stem cell-based approaches for the in vitro study of human cardiac physiology and pathophysiology. We present a method to comprehensively assess the function of single human pluripotent stem cell-derived cardiomyocyte (hPSC-CMs through simultaneous quantitative analysis of contraction kinetics, force generation, and electrical activity. We demonstrate that statistical analysis of movies of contracting hPSC-CMs can be used to quantify changes in cellular morphology over time and compute contractile kinetics. Using a biomechanical model that incorporates substrate stiffness, we calculate cardiomyocyte force generation at single-cell resolution and validate this approach with conventional traction force microscopy. The addition of fluorescent calcium indicators or membrane potential dyes allows the simultaneous analysis of contractility and calcium handling or action potential morphology. Accordingly, our approach has the potential for broad application in the study of cardiac disease, drug discovery, and cardiotoxicity screening.

  3. The development of municipal solid waste treatment technology based on refuse derived fuel and bio-gasification integration

    International Nuclear Information System (INIS)

    Muhd Noor Muhd Yunus

    2006-01-01

    The amount of MSW generated in big cities in Malaysia is very alarming. In Kuala Lumpur, the total waste generated is about 2,500 t/day. The existing landfills are being overused and should have been closed by now. However, till today, the solution is not really in place. The Government is planning to build a 1200 t/day Gasification and Ash Melting (GAMF) plant to partially resolve the above problem in Kuala Lumpur. However, even though environmentally rated as one of the best, technology is not cheap, thus failed to meet the BATNEEC concept. Currently, the Government, through the Strategic Master Plan, encourages the development of local technologies that are cheap and yet comply to international standards. As such, a private company, Recycle Energy Sdn Bhd (RESB), took the initiative to develop the RDF from Malaysian MSW. MINT Incineration and Renewable Energy Center (MIREC) has been commissioned to collaborate in the development of this technology, together with Universiti Putra Malaysia (UPM). A 15 t/day pilot scale RDF plant was established in 2001 in Kajang, to refine the concept as well as to establish more data. One year later, the company was given permission by the Government to set up a 700 t/day commercial facility in Semenyih, based on early success of the pilot testing done in Kajang. The integration of RDF, Anaerobic Digester and Fuel Cell Technology is adopted to generate in house power and export to the national grid, besides recycling a portion of the waste materials. This integration seems to be the best environmental as well as economic option that complies to BATNEEC concept. This paper highlights and discusses the issues and challenges in the process of developing RDF technology, both at the pilot scale R and D as well as the commercial scale plant planning

  4. Xeno-Free and Defined Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large-Eyed Preclinical Model

    Directory of Open Access Journals (Sweden)

    Alvaro Plaza Reyes

    2016-01-01

    Full Text Available Human embryonic stem cell (hESC-derived retinal pigment epithelial (RPE cells could replace lost tissue in geographic atrophy (GA but efficacy has yet to be demonstrated in a large-eyed model. Also, production of hESC-RPE has not yet been achieved in a xeno-free and defined manner, which is critical for clinical compliance and reduced immunogenicity. Here we describe an effective differentiation methodology using human laminin-521 matrix with xeno-free and defined medium. Differentiated cells exhibited characteristics of native RPE including morphology, pigmentation, marker expression, monolayer integrity, and polarization together with phagocytic activity. Furthermore, we established a large-eyed GA model that allowed in vivo imaging of hESC-RPE and host retina. Cells transplanted in suspension showed long-term integration and formed polarized monolayers exhibiting phagocytic and photoreceptor rescue capacity. We have developed a xeno-free and defined hESC-RPE differentiation method and present evidence of functional integration of clinically compliant hESC-RPE in a large-eyed disease model.

  5. Computational mate choice: theory and empirical evidence.

    Science.gov (United States)

    Castellano, Sergio; Cadeddu, Giorgia; Cermelli, Paolo

    2012-06-01

    The present review is based on the thesis that mate choice results from information-processing mechanisms governed by computational rules and that, to understand how females choose their mates, we should identify which are the sources of information and how they are used to make decisions. We describe mate choice as a three-step computational process and for each step we present theories and review empirical evidence. The first step is a perceptual process. It describes the acquisition of evidence, that is, how females use multiple cues and signals to assign an attractiveness value to prospective mates (the preference function hypothesis). The second step is a decisional process. It describes the construction of the decision variable (DV), which integrates evidence (private information by direct assessment), priors (public information), and value (perceived utility) of prospective mates into a quantity that is used by a decision rule (DR) to produce a choice. We make the assumption that females are optimal Bayesian decision makers and we derive a formal model of DV that can explain the effects of preference functions, mate copying, social context, and females' state and condition on the patterns of mate choice. The third step of mating decision is a deliberative process that depends on the DRs. We identify two main categories of DRs (absolute and comparative rules), and review the normative models of mate sampling tactics associated to them. We highlight the limits of the normative approach and present a class of computational models (sequential-sampling models) that are based on the assumption that DVs accumulate noisy evidence over time until a decision threshold is reached. These models force us to rethink the dichotomy between comparative and absolute decision rules, between discrimination and recognition, and even between rational and irrational choice. Since they have a robust biological basis, we think they may represent a useful theoretical tool for

  6. Simulated Annealing-based Optimal Proportional-Integral-Derivative (PID) Controller Design: A Case Study on Nonlinear Quadcopter Dynamics

    Science.gov (United States)

    Nemirsky, Kristofer Kevin

    In this thesis, the history and evolution of rotor aircraft with simulated annealing-based PID application were reviewed and quadcopter dynamics are presented. The dynamics of a quadcopter were then modeled, analyzed, and linearized. A cascaded loop architecture with PID controllers was used to stabilize the plant dynamics, which was improved upon through the application of simulated annealing (SA). A Simulink model was developed to test the controllers and verify the functionality of the proposed control system design. In addition, the data that the Simulink model provided were compared with flight data to present the validity of derived dynamics as a proper mathematical model representing the true dynamics of the quadcopter system. Then, the SA-based global optimization procedure was applied to obtain optimized PID parameters. It was observed that the tuned gains through the SA algorithm produced a better performing PID controller than the original manually tuned one. Next, we investigated the uncertain dynamics of the quadcopter setup. After adding uncertainty to the gyroscopic effects associated with pitch-and-roll rate dynamics, the controllers were shown to be robust against the added uncertainty. A discussion follows to summarize SA-based algorithm PID controller design and performance outcomes. Lastly, future work on SA application on multi-input-multi-output (MIMO) systems is briefly discussed.

  7. Path-integral derivation of black-hole radiance inside the de-Rham-Gabadadze-Tolley formulation of massive gravity

    Energy Technology Data Exchange (ETDEWEB)

    Arraut, Ivan [Institute of Theoretical Physics, Chinese Academy of Science, State Key Laboratory of Theoretical Physics, Beijing (China)

    2017-08-15

    If we apply the path-integral formulation in order to analyze the particle creation process of black holes inside the non-linear formulation of massive gravity, it is possible to demonstrate that the effect of the extra degrees of freedom is to deform the periodicity of the poles of the propagator in the complex t-plane. This might create the effect of extra particle creation process at scales where the extra degrees of freedom become relevant. For stationary solutions, depending on the values taken by the free parameters of the theory, the periodicity structure of the propagator reveal two effects. The first one is a shift on the positions of the pole of the propagator with respect to the GR case, affecting then the instant at which the particles are detected. The second one is the existence of branch points, affecting then the perception of particles. The branch point can be finite (including the zero order case) or infinite, depending on the free parameters of the theory. (orig.)

  8. Path-integral derivation of black-hole radiance inside the de-Rham-Gabadadze-Tolley formulation of massive gravity

    International Nuclear Information System (INIS)

    Arraut, Ivan

    2017-01-01

    If we apply the path-integral formulation in order to analyze the particle creation process of black holes inside the non-linear formulation of massive gravity, it is possible to demonstrate that the effect of the extra degrees of freedom is to deform the periodicity of the poles of the propagator in the complex t-plane. This might create the effect of extra particle creation process at scales where the extra degrees of freedom become relevant. For stationary solutions, depending on the values taken by the free parameters of the theory, the periodicity structure of the propagator reveal two effects. The first one is a shift on the positions of the pole of the propagator with respect to the GR case, affecting then the instant at which the particles are detected. The second one is the existence of branch points, affecting then the perception of particles. The branch point can be finite (including the zero order case) or infinite, depending on the free parameters of the theory. (orig.)

  9. Integrated hard and soft bottom seafloor substrate map derived from an unsupervised classification of gridded backscatter, World-View 2 imagery and bathymetry derivatives of Ni'ihau Island, Hawaii, USA.

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Preliminary hard and soft seafloor substrate map derived from an unsupervised classification of multibeam backscatter, bathymety derivatives, and bathymetry derived...

  10. Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells.

    Science.gov (United States)

    Wang, Linli; Chen, Yuehua; Guan, Chunyan; Zhao, Zhiju; Li, Qiang; Yang, Jianguo; Mo, Jian; Wang, Bin; Wu, Wei; Yang, Xiaohui; Song, Libing; Li, Jun

    2017-11-02

    Because the lack of an induced pluripotent stem cell (iPSC) induction system with optimal safety and efficiency limits the application of these cells, development of such a system is important. To create such an induction system, we screened a variety of reprogrammed plasmid combinations and multiple compounds and then verified the system's feasibility using urine cells from different individuals. We also compared large-scale iPSC chromosomal variations and expression of genes associated with genomic stability between this system and the traditional episomal system using karyotype and quantitative reverse transcription polymerase chain reaction analyses. We developed a high-efficiency episomal system, the 6F/BM1-4C system, lacking tumorigenic factors for human urine-derived cell (hUC) reprogramming. This system includes six low-risk factors (6F), Oct4, Glis1, Klf4, Sox2, L-Myc, and the miR-302 cluster. Transfected hUCs were treated with four compounds (4C), inhibitor of lysine-demethylase1, methyl ethyl ketone, glycogen synthase kinase 3 beta, and histone deacetylase, within a short time period. Comparative analysis revealed significantly decreased chromosomal variation in iPSCs and significantly increased Sirt1 expression compared with iPSCs induced using the traditional episomal system. The 6F/BM1-4C system effectively induces reprogramming of urine cells in samples obtained from different individuals. iPSCs induced using the 6F/BM1-4C system are more stable at the cytogenetic level and have potential value for clinical application.

  11. Generation of Integration-Free Induced Pluripotent Stem Cells from Urine-Derived Cells Isolated from Individuals with Down Syndrome.

    Science.gov (United States)

    M Lee, Young; Zampieri, Bruna L; Scott-McKean, Jonah J; Johnson, Mark W; Costa, Alberto C S

    2017-06-01

    Down syndrome (DS) is a genetic disorder caused by trisomy 21 (T21). Over the past two decades, the use of mouse models has led to significant advances in the understanding of mechanisms underlying various phenotypic features and comorbidities secondary to T21 and even informed the design of clinical trials aimed at enhancing the cognitive abilities of persons with DS. In spite of its success, this approach has been plagued by all the typical limitations of rodent modeling of human disorders and diseases. Recently, several laboratories have succeeded in producing T21 human induced pluripotent stem cells (T21-iPSCs) from individuals with DS, which is emerging as a promising complementary tool for the study of DS. Here, we describe the method by which we generated 10 T21-iPSC lines from epithelial cells in urine samples, presumably from kidney epithelial origin, using nonintegrating episomal vectors. We also show that these iPSCs maintain chromosomal stability for well over 20 passages and are more sensitive to proteotoxic stress than euploid iPSCs. Furthermore, these iPSC lines can be differentiated into glutamatergic neurons and cardiomyocytes. By culturing urine-derived cells and maximizing the efficiency of episomal vector transfection, we have been able to generate iPSCs noninvasively and effectively from participants with DS in an ongoing clinical trial, and thus address most shortcomings of previously generated T21-iPSC lines. These techniques should extend the application of iPSCs in modeling DS and other neurodevelopmental and neurodegenerative disorders, and may lead to future human cell-based platforms for high-throughput drug screening. Stem Cells Translational Medicine 2017;6:1465-1476. © 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

  12. Preliminary evaluation of MRI-derived input function for quantitative measurement of glucose metabolism in an integrated PET-MRI

    International Nuclear Information System (INIS)

    Anazodo, Udunna; Kewin, Matthew; Finger, Elizabeth; Thiessen, Jonathan; Hadway, Jennifer; Butler, John; Pavlosky, William; Prato, Frank; Thompson, Terry; St Lawrence, Keith

    2015-01-01

    PET semi-quantitative methods such as relative uptake value can be robust but offer no biological information and do not account for intra-subject variability in tracer administration or clearance. Simultaneous multimodal measurements that combine PET and MRI not only permit crucial multiparametric measurements, it provides means of applying tracer kinetic modelling without the need for serial arterial blood sampling. In this study we adapted an image-derived input function (IDIF) method to improve characterization of glucose metabolism in an ongoing dementia study. Here we present preliminary results in a small group of frontotemporal dementia patients and controls. IDIF was obtained directly from dynamic PET data guided by regions of interest drawn on carotid vessels on high resolution T1-weighted MR Images. IDIF was corrected for contamination of non-arterial voxels. A validation of the method was performed in a porcine model in a PET-CT scanner comparing IDIF to direct arterial blood samples. Metabolic rate of glucose (CMRglc) was measured voxel-by-voxel in gray matter producing maps that were compared between groups. Net influx rate (Ki) and global mean CMRglc are reported. A good correlation (r = 0.9 p<0.0001) was found between corrected IDIF and input function measured from direct arterial blood sampling in the validation study. In 3 FTD and 3 controls, a trend towards hypometabolism was found in frontal, temporal and parietal lobes similar to significant differences previously reported by other groups. The global mean CMRglc and Ki observed in control subjects are in line with previous reports. In general, kinetic modelling of PET-FDG using an MR-IDIF can improve characterization of glucose metabolism in dementia. This method is feasible in multimodal studies that aim to combine PET molecular imaging with MRI as dynamic PET can be acquired along with multiple MRI measurements.

  13. Preliminary evaluation of MRI-derived input function for quantitative measurement of glucose metabolism in an integrated PET-MRI

    Energy Technology Data Exchange (ETDEWEB)

    Anazodo, Udunna; Kewin, Matthew [Lawson Health Research Institute, Department of Medical Biophysics, Western University, London, Ontario (Canada); Finger, Elizabeth [Department of Clinical Neurological Sciences, Western University, London, Ontario (Canada); Thiessen, Jonathan; Hadway, Jennifer; Butler, John [Lawson Health Research Institute, Department of Medical Biophysics, Western University, London, Ontario (Canada); Pavlosky, William [Diagnostic Imaging, St Joseph' s Health Care, London, Ontario (Canada); Prato, Frank; Thompson, Terry; St Lawrence, Keith [Lawson Health Research Institute, Department of Medical Biophysics, Western University, London, Ontario (Canada)

    2015-05-18

    PET semi-quantitative methods such as relative uptake value can be robust but offer no biological information and do not account for intra-subject variability in tracer administration or clearance. Simultaneous multimodal measurements that combine PET and MRI not only permit crucial multiparametric measurements, it provides means of applying tracer kinetic modelling without the need for serial arterial blood sampling. In this study we adapted an image-derived input function (IDIF) method to improve characterization of glucose metabolism in an ongoing dementia study. Here we present preliminary results in a small group of frontotemporal dementia patients and controls. IDIF was obtained directly from dynamic PET data guided by regions of interest drawn on carotid vessels on high resolution T1-weighted MR Images. IDIF was corrected for contamination of non-arterial voxels. A validation of the method was performed in a porcine model in a PET-CT scanner comparing IDIF to direct arterial blood samples. Metabolic rate of glucose (CMRglc) was measured voxel-by-voxel in gray matter producing maps that were compared between groups. Net influx rate (Ki) and global mean CMRglc are reported. A good correlation (r = 0.9 p<0.0001) was found between corrected IDIF and input function measured from direct arterial blood sampling in the validation study. In 3 FTD and 3 controls, a trend towards hypometabolism was found in frontal, temporal and parietal lobes similar to significant differences previously reported by other groups. The global mean CMRglc and Ki observed in control subjects are in line with previous reports. In general, kinetic modelling of PET-FDG using an MR-IDIF can improve characterization of glucose metabolism in dementia. This method is feasible in multimodal studies that aim to combine PET molecular imaging with MRI as dynamic PET can be acquired along with multiple MRI measurements.

  14. Construction of an integrated genetic linkage map for the A genome of Brassica napus using SSR markers derived from sequenced BACs in B. rapa

    Directory of Open Access Journals (Sweden)

    King Graham J

    2010-10-01

    Full Text Available Abstract Background The Multinational Brassica rapa Genome Sequencing Project (BrGSP has developed valuable genomic resources, including BAC libraries, BAC-end sequences, genetic and physical maps, and seed BAC sequences for Brassica rapa. An integrated linkage map between the amphidiploid B. napus and diploid B. rapa will facilitate the rapid transfer of these valuable resources from B. rapa to B. napus (Oilseed rape, Canola. Results In this study, we identified over 23,000 simple sequence repeats (SSRs from 536 sequenced BACs. 890 SSR markers (designated as BrGMS were developed and used for the construction of an integrated linkage map for the A genome in B. rapa and B. napus. Two hundred and nineteen BrGMS markers were integrated to an existing B. napus linkage map (BnaNZDH. Among these mapped BrGMS markers, 168 were only distributed on the A genome linkage groups (LGs, 18 distrubuted both on the A and C genome LGs, and 33 only distributed on the C genome LGs. Most of the A genome LGs in B. napus were collinear with the homoeologous LGs in B. rapa, although minor inversions or rearrangements occurred on A2 and A9. The mapping of these BAC-specific SSR markers enabled assignment of 161 sequenced B. rapa BACs, as well as the associated BAC contigs to the A genome LGs of B. napus. Conclusion The genetic mapping of SSR markers derived from sequenced BACs in B. rapa enabled direct links to be established between the B. napus linkage map and a B. rapa physical map, and thus the assignment of B. rapa BACs and the associated BAC contigs to the B. napus linkage map. This integrated genetic linkage map will facilitate exploitation of the B. rapa annotated genomic resources for gene tagging and map-based cloning in B. napus, and for comparative analysis of the A genome within Brassica species.

  15. MRO CRISM TARGETED EMPIRICAL RECORD V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — This volume contains the CRISM Targeted Empirical Record (TER) archive, a collection of multiband image cubes derived from targeted (gimbaled) observations of Mars'...

  16. Simple locking of infrared and ultraviolet diode lasers to a visible laser using a LabVIEW proportional-integral-derivative controller on a Fabry-Perot signal.

    Science.gov (United States)

    Kwolek, J M; Wells, J E; Goodman, D S; Smith, W W

    2016-05-01

    Simultaneous laser locking of infrared (IR) and ultraviolet lasers to a visible stabilized reference laser is demonstrated via a Fabry-Perot (FP) cavity. LabVIEW is used to analyze the input, and an internal proportional-integral-derivative algorithm converts the FP signal to an analog locking feedback signal. The locking program stabilized both lasers to a long term stability of better than 9 MHz, with a custom-built IR laser undergoing significant improvement in frequency stabilization. The results of this study demonstrate the viability of a simple, computer-controlled, non-temperature-stabilized FP locking scheme for our applications, laser cooling of Ca(+) ions, and its use in other applications with similar modest frequency stabilization requirements.

  17. IC-tagged proteins are able to interact with each other and perform complex reactions when integrated into muNS-derived inclusions.

    Science.gov (United States)

    Brandariz-Nuñez, Alberto; Otero-Romero, Iria; Benavente, Javier; Martinez-Costas, Jose M

    2011-09-20

    We have recently developed a versatile tagging system (IC-tagging) that causes relocation of the tagged proteins to ARV muNS-derived intracellular globular inclusions. In the present study we demonstrate (i) that the IC-tag can be successfully fused either to the amino or carboxyl terminus of the protein to be tagged and (ii) that IC-tagged proteins are able to interact between them and perform complex reactions that require such interactions while integrated into muNS inclusions, increasing the versatility of the IC-tagging system. Also, our studies with the DsRed protein add some light on the structure/function relationship of the evolution of DsRed chromophore. Copyright © 2011 Elsevier B.V. All rights reserved.

  18. Empirical comparison of theories

    International Nuclear Information System (INIS)

    Opp, K.D.; Wippler, R.

    1990-01-01

    The book represents the first, comprehensive attempt to take an empirical approach for comparative assessment of theories in sociology. The aims, problems, and advantages of the empirical approach are discussed in detail, and the three theories selected for the purpose of this work are explained. Their comparative assessment is performed within the framework of several research projects, which among other subjects also investigate the social aspects of the protest against nuclear power plants. The theories analysed in this context are the theory of mental incongruities and that of the benefit, and their efficiency in explaining protest behaviour is compared. (orig./HSCH) [de

  19. Empirical Music Aesthetics

    DEFF Research Database (Denmark)

    Grund, Cynthia M.

    The toolbox for empirically exploring the ways that artistic endeavors convey and activate meaning on the part of performers and audiences continues to expand. Current work employing methods at the intersection of performance studies, philosophy, motion capture and neuroscience to better understand...... musical performance and reception is inspired by traditional approaches within aesthetics, but it also challenges some of the presuppositions inherent in them. As an example of such work I present a research project in empirical music aesthetics begun last year and of which I am a team member....

  20. A high performance lithium ion capacitor achieved by the integration of a Sn-C anode and a biomass-derived microporous activated carbon cathode.

    Science.gov (United States)

    Sun, Fei; Gao, Jihui; Zhu, Yuwen; Pi, Xinxin; Wang, Lijie; Liu, Xin; Qin, Yukun

    2017-02-03

    Hybridizing battery and capacitor materials to construct lithium ion capacitors (LICs) has been regarded as a promising avenue to bridge the gap between high-energy lithium ion batteries and high-power supercapacitors. One of the key difficulties in developing advanced LICs is the imbalance in the power capability and charge storage capacity between anode and cathode. Herein, we design a new LIC system by integrating a rationally designed Sn-C anode with a biomass-derived activated carbon cathode. The Sn-C nanocomposite obtained by a facile confined growth strategy possesses multiple structural merits including well-confined Sn nanoparticles, homogeneous distribution and interconnected carbon framework with ultra-high N doping level, synergically enabling the fabricated anode with high Li storage capacity and excellent rate capability. A new type of biomass-derived activated carbon featuring both high surface area and high carbon purity is also prepared to achieve high capacity for cathode. The assembled LIC (Sn-C//PAC) device delivers high energy densities of 195.7 Wh kg -1 and 84.6 Wh kg -1 at power densities of 731.25 W kg -1 and 24375 W kg -1 , respectively. This work offers a new strategy for designing high-performance hybrid system by tailoring the nanostructures of Li insertion anode and ion adsorption cathode.

  1. Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after rat spinal cord transection.

    Science.gov (United States)

    Zeng, Xiang; Qiu, Xue-Cheng; Ma, Yuan-Huan; Duan, Jing-Jing; Chen, Yuan-Feng; Gu, Huai-Yu; Wang, Jun-Mei; Ling, Eng-Ang; Wu, Jin-Lang; Wu, Wutian; Zeng, Yuan-Shan

    2015-06-01

    Functional deficits following spinal cord injury (SCI) primarily attribute to loss of neural connectivity. We therefore tested if novel tissue engineering approaches could enable neural network repair that facilitates functional recovery after spinal cord transection (SCT). Rat bone marrow-derived mesenchymal stem cells (MSCs), genetically engineered to overexpress TrkC, receptor of neurotrophin-3 (NT-3), were pre-differentiated into cells carrying neuronal features via co-culture with NT-3 overproducing Schwann cells in 3-dimensional gelatin sponge (GS) scaffold for 14 days in vitro. Intra-GS formation of MSC assemblies emulating neural network (MSC-GS) were verified morphologically via electron microscopy (EM) and functionally by whole-cell patch clamp recording of spontaneous post-synaptic currents. The differentiated MSCs still partially maintained prototypic property with the expression of some mesodermal cytokines. MSC-GS or GS was then grafted acutely into a 2 mm-wide transection gap in the T9-T10 spinal cord segments of adult rats. Eight weeks later, hindlimb function of the MSC-GS-treated SCT rats was significantly improved relative to controls receiving the GS or lesion only as indicated by BBB score. The MSC-GS transplantation also significantly recovered cortical motor evoked potential (CMEP). Histologically, MSC-derived neuron-like cells maintained their synapse-like structures in vivo; they additionally formed similar connections with host neurites (i.e., mostly serotonergic fibers plus a few corticospinal axons; validated by double-labeled immuno-EM). Moreover, motor cortex electrical stimulation triggered c-fos expression in the grafted and lumbar spinal cord cells of the treated rats only. Our data suggest that MSC-derived neuron-like cells resulting from NT-3-TrkC-induced differentiation can partially integrate into transected spinal cord and this strategy should be further investigated for reconstructing disrupted neural circuits. Copyright

  2. Initializing numerical weather prediction models with satellite-derived surface soil moisture: Data assimilation experiments with ECMWF's Integrated Forecast System and the TMI soil moisture data set

    Science.gov (United States)

    Drusch, M.

    2007-02-01

    Satellite-derived surface soil moisture data sets are readily available and have been used successfully in hydrological applications. In many operational numerical weather prediction systems the initial soil moisture conditions are analyzed from the modeled background and 2 m temperature and relative humidity. This approach has proven its efficiency to improve surface latent and sensible heat fluxes and consequently the forecast on large geographical domains. However, since soil moisture is not always related to screen level variables, model errors and uncertainties in the forcing data can accumulate in root zone soil moisture. Remotely sensed surface soil moisture is directly linked to the model's uppermost soil layer and therefore is a stronger constraint for the soil moisture analysis. For this study, three data assimilation experiments with the Integrated Forecast System (IFS) of the European Centre for Medium-Range Weather Forecasts (ECMWF) have been performed for the 2-month period of June and July 2002: a control run based on the operational soil moisture analysis, an open loop run with freely evolving soil moisture, and an experimental run incorporating TMI (TRMM Microwave Imager) derived soil moisture over the southern United States. In this experimental run the satellite-derived soil moisture product is introduced through a nudging scheme using 6-hourly increments. Apart from the soil moisture analysis, the system setup reflects the operational forecast configuration including the atmospheric 4D-Var analysis. Soil moisture analyzed in the nudging experiment is the most accurate estimate when compared against in situ observations from the Oklahoma Mesonet. The corresponding forecast for 2 m temperature and relative humidity is almost as accurate as in the control experiment. Furthermore, it is shown that the soil moisture analysis influences local weather parameters including the planetary boundary layer height and cloud coverage.

  3. Generation of human-induced pluripotent stem cells from burn patient-derived skin fibroblasts using a non-integrative method.

    Science.gov (United States)

    Fu, Shangfeng; Ding, Jianwu; Liu, Dewu; Huang, Heping; Li, Min; Liu, Yang; Tu, Longxiang; Liu, Deming

    2018-01-01

    Patient specific induced pluripotent stem cells (iPSCs) have been recognized as a possible source of cells for skin tissue engineering. They have the potential to greatly benefit patients with large areas of burned skin or skin defects. However, the integration virus-based reprogramming method is associated with a high risk of genetic mutation and mouse embryonic fibroblast feeder-cells may be a pollutant. In the present study, human skin fibroblasts (HSFs) were successfully harvested from patients with burns and patient-specific iPSCs were generated using a non-integration method with a feeder-free approach. The octamer-binding transcription factor 4 (OCT4), sex-determining region Y box 2 (SOX2) and NANOG transcription factors were delivered using Sendai virus vectors. iPSCs exhibited representative human embryonic stem cell-like morphology and proliferation characteristics. They also expressed pluripotent markers, including OCT4, NANOG, SOX2, TRA181, stage-specific embryonic antigen 4 and TRA-160, and exhibited a normal karyotype. Teratoma and embryoid body formation revealed that iPSCs were able to differentiate into cells of all three germ layers in vitro and in vivo. The results of the present study demonstrate that HSFs derived from patients with burns, may be reprogrammed into stem cells with pluripotency, which provides a basis for cell‑based skin tissue engineering in the future.

  4. Empirical research through design

    NARCIS (Netherlands)

    Keyson, D.V.; Bruns, M.

    2009-01-01

    This paper describes the empirical research through design method (ERDM), which differs from current approaches to research through design by enforcing the need for the designer, after a series of pilot prototype based studies, to a-priori develop a number of testable interaction design hypothesis

  5. Essays in empirical microeconomics

    NARCIS (Netherlands)

    Péter, A.N.

    2016-01-01

    The empirical studies in this thesis investigate various factors that could affect individuals' labor market, family formation and educational outcomes. Chapter 2 focuses on scheduling as a potential determinant of individuals' productivity. Chapter 3 looks at the role of a family factor on

  6. Worship, Reflection, Empirical Research

    OpenAIRE

    Ding Dong,

    2012-01-01

    In my youth, I was a worshipper of Mao Zedong. From the latter stage of the Mao Era to the early years of Reform and Opening, I began to reflect on Mao and the Communist Revolution he launched. In recent years I’ve devoted myself to empirical historical research on Mao, seeking the truth about Mao and China’s modern history.

  7. Trade and Empire

    DEFF Research Database (Denmark)

    Bang, Peter Fibiger

    2007-01-01

    This articles seeks to establish a new set of organizing concepts for the analysis of the Roman imperial economy from Republic to late antiquity: tributary empire, port-folio capitalism and protection costs. Together these concepts explain better economic developments in the Roman world than the...

  8. Empirically sampling Universal Dependencies

    DEFF Research Database (Denmark)

    Schluter, Natalie; Agic, Zeljko

    2017-01-01

    Universal Dependencies incur a high cost in computation for unbiased system development. We propose a 100% empirically chosen small subset of UD languages for efficient parsing system development. The technique used is based on measurements of model capacity globally. We show that the diversity o...

  9. Merged ontology for engineering design: Contrasting empirical and theoretical approaches to develop engineering ontologies

    DEFF Research Database (Denmark)

    Ahmed, Saeema; Storga, M

    2009-01-01

    to developing the ontology engineering design integrated taxonomies (EDIT) with a theoretical approach in which concepts and relations are elicited from engineering design theories ontology (DO) The limitations and advantages of each approach are discussed. The research methodology adopted is to map......This paper presents a comparison of two previous and separate efforts to develop an ontology in the engineering design domain, together with an ontology proposal from which ontologies for a specific application may be derived. The research contrasts an empirical, user-centered approach...

  10. Symbiotic empirical ethics: a practical methodology.

    Science.gov (United States)

    Frith, Lucy

    2012-05-01

    Like any discipline, bioethics is a developing field of academic inquiry; and recent trends in scholarship have been towards more engagement with empirical research. This 'empirical turn' has provoked extensive debate over how such 'descriptive' research carried out in the social sciences contributes to the distinctively normative aspect of bioethics. This paper will address this issue by developing a practical research methodology for the inclusion of data from social science studies into ethical deliberation. This methodology will be based on a naturalistic conception of ethical theory that sees practice as informing theory just as theory informs practice - the two are symbiotically related. From this engagement with practice, the ways that such theories need to be extended and developed can be determined. This is a practical methodology for integrating theory and practice that can be used in empirical studies, one that uses ethical theory both to explore the data and to draw normative conclusions. © 2010 Blackwell Publishing Ltd.

  11. Autobiography After Empire

    DEFF Research Database (Denmark)

    Rasch, Astrid

    of the collective, but insufficient attention has been paid to how individuals respond to such narrative changes. This dissertation examines the relationship between individual and collective memory at the end of empire through analysis of 13 end of empire autobiographies by public intellectuals from Australia......Decolonisation was a major event of the twentieth century, redrawing maps and impacting on identity narratives around the globe. As new nations defined their place in the world, the national and imperial past was retold in new cultural memories. These developments have been studied at the level......, the Anglophone Caribbean and Zimbabwe. I conceive of memory as reconstructive and social, with individual memory striving to make sense of the past in the present in dialogue with surrounding narratives. By examining recurring tropes in the autobiographies, like colonial education, journeys to the imperial...

  12. Gazprom: the new empire

    International Nuclear Information System (INIS)

    Guillemoles, A.; Lazareva, A.

    2008-01-01

    Gazprom is conquering the world. The Russian industrial giant owns the hugest gas reserves and enjoys the privilege of a considerable power. Gazprom edits journals, owns hospitals, airplanes and has even built cities where most of the habitants work for him. With 400000 workers, Gazprom represents 8% of Russia's GDP. This inquiry describes the history and operation of this empire and show how its has become a masterpiece of the government's strategy of russian influence reconquest at the world scale. Is it going to be a winning game? Are the corruption affairs and the expected depletion of resources going to weaken the empire? The authors shade light on the political and diplomatic strategies that are played around the crucial dossier of the energy supply. (J.S.)

  13. Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data.

    Science.gov (United States)

    Holmgren, Gustav; Sartipy, Peter; Andersson, Christian X; Lindahl, Anders; Synnergren, Jane

    2018-05-01

    Anthracyclines, such as doxorubicin, are highly efficient chemotherapeutic agents against a variety of cancers. However, anthracyclines are also among the most cardiotoxic therapeutic drugs presently on the market. Chemotherapeutic-induced cardiomyopathy is one of the leading causes of disease and mortality in cancer survivors. The exact mechanisms responsible for doxorubicin-induced cardiomyopathy are not completely known, but the fact that the cardiotoxicity is dose-dependent and that there is a variation in time-to-onset of toxicity, and gender- and age differences suggests that several mechanisms may be involved. In this study, we investigated doxorubicin-induced cardiotoxicity in human pluripotent stem cell-derived cardiomyocytes using proteomics. In addition, different sources of omics data (protein, mRNA, and microRNA) from the same experimental setup were further combined and analyzed using newly developed methods to identify differential expression in data of various origin and types. Subsequently, the results were integrated in order to generate a combined visualization of the findings. In our experimental model system, we exposed cardiomyocytes derived from human pluripotent stem cells to doxorubicin for up to 2 days, followed by a wash-out period of additionally 12 days. Besides an effect on the cell morphology and cardiomyocyte functionality, the data show a strong effect of doxorubicin on all molecular levels investigated. Differential expression patterns that show a linkage between the proteome, transcriptome, and the regulatory microRNA network, were identified. These findings help to increase the understanding of the mechanisms behind anthracycline-induced cardiotoxicity and suggest putative biomarkers for this condition.

  14. International trade standards for commodities and products derived from animals: the need for a system that integrates food safety and animal disease risk management.

    Science.gov (United States)

    Thomson, G R; Penrith, M-L; Atkinson, M W; Thalwitzer, S; Mancuso, A; Atkinson, S J; Osofsky, S A

    2013-12-01

    A case is made for greater emphasis to be placed on value chain management as an alternative to geographically based disease risk mitigation for trade in commodities and products derived from animals. The geographic approach is dependent upon achievement of freedom in countries or zones from infectious agents that cause so-called transboundary animal diseases, while value chain-based risk management depends upon mitigation of animal disease hazards potentially associated with specific commodities or products irrespective of the locality of production. This commodity-specific approach is founded on the same principles upon which international food safety standards are based, viz. hazard analysis critical control points (HACCP). Broader acceptance of a value chain approach enables animal disease risk management to be combined with food safety management by the integration of commodity-based trade and HACCP methodologies and thereby facilitates 'farm to fork' quality assurance. The latter is increasingly recognized as indispensable to food safety assurance and is therefore a pre-condition to safe trade. The biological principles upon which HACCP and commodity-based trade are based are essentially identical, potentially simplifying sanitary control in contrast to current separate international sanitary standards for food safety and animal disease risks that are difficult to reconcile. A value chain approach would not only enable more effective integration of food safety and animal disease risk management of foodstuffs derived from animals but would also ameliorate adverse environmental and associated socio-economic consequences of current sanitary standards based on the geographic distribution of animal infections. This is especially the case where vast veterinary cordon fencing systems are relied upon to separate livestock and wildlife as is the case in much of southern Africa. A value chain approach would thus be particularly beneficial to under-developed regions of

  15. Physical Limitations of Empirical Field Models: Force Balance and Plasma Pressure

    International Nuclear Information System (INIS)

    Sorin Zaharia; Cheng, C.Z.

    2002-01-01

    In this paper, we study whether the magnetic field of the T96 empirical model can be in force balance with an isotropic plasma pressure distribution. Using the field of T96, we obtain values for the pressure P by solving a Poisson-type equation (gradient) 2 P = (gradient) · (J x B) in the equatorial plane, and 1-D profiles on the Sun-Earth axis by integrating (gradient)P = J x B. We work in a flux coordinate system in which the magnetic field is expressed in terms of Euler potentials. Our results lead to the conclusion that the T96 model field cannot be in equilibrium with an isotropic pressure. We also analyze in detail the computation of Birkeland currents using the Vasyliunas relation and the T96 field, which yields unphysical results, again indicating the lack of force balance in the empirical model. The underlying reason for the force imbalance is likely the fact that the derivatives of the least-square fitted model B are not accurate predictions of the actual magnetospheric field derivatives. Finally, we discuss a possible solution to the problem of lack of force balance in empirical field models

  16. Thermodynamic Characterization of Hydration Sites from Integral Equation-Derived Free Energy Densities: Application to Protein Binding Sites and Ligand Series.

    Science.gov (United States)

    Güssregen, Stefan; Matter, Hans; Hessler, Gerhard; Lionta, Evanthia; Heil, Jochen; Kast, Stefan M

    2017-07-24

    Water molecules play an essential role for mediating interactions between ligands and protein binding sites. Displacement of specific water molecules can favorably modulate the free energy of binding of protein-ligand complexes. Here, the nature of water interactions in protein binding sites is investigated by 3D RISM (three-dimensional reference interaction site model) integral equation theory to understand and exploit local thermodynamic features of water molecules by ranking their possible displacement in structure-based design. Unlike molecular dynamics-based approaches, 3D RISM theory allows for fast and noise-free calculations using the same detailed level of solute-solvent interaction description. Here we correlate molecular water entities instead of mere site density maxima with local contributions to the solvation free energy using novel algorithms. Distinct water molecules and hydration sites are investigated in multiple protein-ligand X-ray structures, namely streptavidin, factor Xa, and factor VIIa, based on 3D RISM-derived free energy density fields. Our approach allows the semiquantitative assessment of whether a given structural water molecule can potentially be targeted for replacement in structure-based design. Finally, PLS-based regression models from free energy density fields used within a 3D-QSAR approach (CARMa - comparative analysis of 3D RISM Maps) are shown to be able to extract relevant information for the interpretation of structure-activity relationship (SAR) trends, as demonstrated for a series of serine protease inhibitors.

  17. Refuse Derived Fuel (RDF) production and gasification in a pilot plant integrated with an Otto cycle ICE through Aspen plus™ modelling: Thermodynamic and economic viability.

    Science.gov (United States)

    Násner, Albany Milena Lozano; Lora, Electo Eduardo Silva; Palacio, José Carlos Escobar; Rocha, Mateus Henrique; Restrepo, Julian Camilo; Venturini, Osvaldo José; Ratner, Albert

    2017-11-01

    This work deals with the development of a Refuse Derived Fuel (RDF) gasification pilot plant using air as a gasification agent. A downdraft fixed bed reactor is integrated with an Otto cycle Internal Combustion Engine (ICE). Modelling was carried out using the Aspen Plus™ software to predict the ideal operational conditions for maximum efficiency. Thermodynamics package used in the simulation comprised the Non-Random Two-Liquid (NRTL) model and the Hayden-O'Connell (HOC) equation of state. As expected, the results indicated that the Equivalence Ratio (ER) has a direct influence over the gasification temperature and the composition of the Raw Produced Gas (RPG), and effects of ER over the Lower Heating Value (LHV) and Cold Gasification Efficiency (CGE) of the RPG are also discussed. A maximum CGE efficiency of 57-60% was reached for ER values between 0.25 and 0.3, also an average reactor temperature values in the range of 680-700°C, with a peak LHV of 5.8MJ/Nm 3 . RPG was burned in an ICE, reaching an electrical power of 50kW el . The economic assessment of the pilot plant implementation was also performed, showing the project is feasible, with power above 120kW el with an initial investment of approximately US$ 300,000. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Compassion: An Evolutionary Analysis and Empirical Review

    OpenAIRE

    Goetz, Jennifer L.; Keltner, Dacher; Simon-Thomas, Emiliana

    2010-01-01

    What is compassion? And how did it evolve? In this review, we integrate three evolutionary arguments that converge on the hypothesis that compassion evolved as a distinct affective experience whose primary function is to facilitate cooperation and protection of the weak and those who suffer. Our empirical review reveals compassion to have distinct appraisal processes attuned to undeserved suffering, distinct signaling behavior related to caregiving patterns of touch, posture, and vocalization...

  19. Statistical mechanics of neocortical interactions. Derivation of short-term-memory capacity

    Science.gov (United States)

    Ingber, Lester

    1984-06-01

    A theory developed by the author to describe macroscopic neocortical interactions demonstrates that empirical values of chemical and electrical parameters of synaptic interactions establish several minima of the path-integral Lagrangian as a function of excitatory and inhibitory columnar firings. The number of possible minima, their time scales of hysteresis and probable reverberations, and their nearest-neighbor columnar interactions are all consistent with well-established empirical rules of human short-term memory. Thus, aspects of conscious experience are derived from neuronal firing patterns, using modern methods of nonlinear nonequilibrium statistical mechanics to develop realistic explicit synaptic interactions.

  20. Empirical limits to antigravity

    International Nuclear Information System (INIS)

    Ericson, T.E.O.; Richter, A.

    1990-01-01

    An upper bound of one part in 10 6 /10 7 is derived for the violation of the equivalence principle for antimatter in the form of antiprotons based on existing data for bulk matter, electrons, positrons, neutrons and protons

  1. Epistemology and Empirical Investigation

    DEFF Research Database (Denmark)

    Ahlström, Kristoffer

    2008-01-01

    Recently, Hilary Kornblith has argued that epistemological investigation is substantially empirical. In the present paper, I will ¿rst show that his claim is not contingent upon the further and, admittedly, controversial assumption that all objects of epistemological investigation are natural kinds....... Then, I will argue that, contrary to what Kornblith seems to assume, this methodological contention does not imply that there is no need for attending to our epistemic concepts in epistemology. Understanding the make-up of our concepts and, in particular, the purposes they ¿ll, is necessary...

  2. Generation of an iPS cell line via a non-integrative method using urine-derived cells from a patient with USH2A-associated retinitis pigmentosa

    Directory of Open Access Journals (Sweden)

    Yonglong Guo

    2018-05-01

    Full Text Available We have established an induced pluripotent stem (iPS cell line using urine-derived cells from a 27-year-old male patient with retinitis pigmentosa associated with point mutations in the USH2A gene. Feeder-free culture conditions and the integration-free CytoTune™-iPS 2.0 Sendai Reprogramming Kit were used.

  3. Monitoring drought affected crop yields based on ERS-scatterometer data : exploration of possibilities to integrate ERS-scatterometer derived soil moisture into the CGMS crop model for a Russian-Ukrainian study area

    NARCIS (Netherlands)

    Boogaard, H.L.; Diepen, van C.A.; Savin, I.

    2000-01-01

    In this study the possibilities of integrating ERS scatterometer-derived soil moisture into CGMS are explored. This remote sensed soil moisture is used to calculate drought stress in grains of barley for a Russian-Ukrainian study area. The results arecompared with drought stress based on the

  4. Racism, empire and sociology

    OpenAIRE

    Smith, Andrew

    2017-01-01

    Reviews of Gurminder K Bhambra, Connected Sociologies; Peo Hansen and Stefan Jonsson, Eurafrica: The Untold History of European Integration and Colonialism; Wulf D. Hund, Alana Lentin (eds) Racism and Sociology

  5. Empirical methods for estimating future climatic conditions

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    Applying the empirical approach permits the derivation of estimates of the future climate that are nearly independent of conclusions based on theoretical (model) estimates. This creates an opportunity to compare these results with those derived from the model simulations of the forthcoming changes in climate, thus increasing confidence in areas of agreement and focusing research attention on areas of disagreements. The premise underlying this approach for predicting anthropogenic climate change is based on associating the conditions of the climatic optimums of the Holocene, Eemian, and Pliocene with corresponding stages of the projected increase of mean global surface air temperature. Provided that certain assumptions are fulfilled in matching the value of the increased mean temperature for a certain epoch with the model-projected change in global mean temperature in the future, the empirical approach suggests that relationships leading to the regional variations in air temperature and other meteorological elements could be deduced and interpreted based on use of empirical data describing climatic conditions for past warm epochs. Considerable care must be taken, of course, in making use of these spatial relationships, especially in accounting for possible large-scale differences that might, in some cases, result from different factors contributing to past climate changes than future changes and, in other cases, might result from the possible influences of changes in orography and geography on regional climatic conditions over time

  6. How rational should bioethics be? The value of empirical approaches.

    Science.gov (United States)

    Alvarez, A A

    2001-10-01

    Rational justification of claims with empirical content calls for empirical and not only normative philosophical investigation. Empirical approaches to bioethics are epistemically valuable, i.e., such methods may be necessary in providing and verifying basic knowledge about cultural values and norms. Our assumptions in moral reasoning can be verified or corrected using these methods. Moral arguments can be initiated or adjudicated by data drawn from empirical investigation. One may argue that individualistic informed consent, for example, is not compatible with the Asian communitarian orientation. But this normative claim uses an empirical assumption that may be contrary to the fact that some Asians do value and argue for informed consent. Is it necessary and factual to neatly characterize some cultures as individualistic and some as communitarian? Empirical investigation can provide a reasonable way to inform such generalizations. In a multi-cultural context, such as in the Philippines, there is a need to investigate the nature of the local ethos before making any appeal to authenticity. Otherwise we may succumb to the same ethical imperialism we are trying hard to resist. Normative claims that involve empirical premises cannot be reasonable verified or evaluated without utilizing empirical methods along with philosophical reflection. The integration of empirical methods to the standard normative approach to moral reasoning should be reasonably guided by the epistemic demands of claims arising from cross-cultural discourse in bioethics.

  7. Critical Realism and Empirical Bioethics: A Methodological Exposition.

    Science.gov (United States)

    McKeown, Alex

    2017-09-01

    This paper shows how critical realism can be used to integrate empirical data and philosophical analysis within 'empirical bioethics'. The term empirical bioethics, whilst appearing oxymoronic, simply refers to an interdisciplinary approach to the resolution of practical ethical issues within the biological and life sciences, integrating social scientific, empirical data with philosophical analysis. It seeks to achieve a balanced form of ethical deliberation that is both logically rigorous and sensitive to context, to generate normative conclusions that are practically applicable to the problem, challenge, or dilemma. Since it incorporates both philosophical and social scientific components, empirical bioethics is a field that is consistent with the use of critical realism as a research methodology. The integration of philosophical and social scientific approaches to ethics has been beset with difficulties, not least because of the irreducibly normative, rather than descriptive, nature of ethical analysis and the contested relation between fact and value. However, given that facts about states of affairs inform potential courses of action and their consequences, there is a need to overcome these difficulties and successfully integrate data with theory. Previous approaches have been formulated to overcome obstacles in combining philosophical and social scientific perspectives in bioethical analysis; however each has shortcomings. As a mature interdisciplinary approach critical realism is well suited to empirical bioethics, although it has hitherto not been widely used. Here I show how it can be applied to this kind of research and explain how it represents an improvement on previous approaches.

  8. The Influence of Tissue Ischemia Time on RNA Integrity and Patient-Derived Xenografts (PDX) Engraftment Rate in a Non-Small Cell Lung Cancer (NSCLC) Biobank.

    Science.gov (United States)

    Guerrera, Francesco; Tabbò, Fabrizio; Bessone, Luca; Maletta, Francesca; Gaudiano, Marcello; Ercole, Elisabetta; Annaratone, Laura; Todaro, Maria; Boita, Monica; Filosso, Pier Luigi; Solidoro, Paolo; Delsedime, Luisa; Oliaro, Alberto; Sapino, Anna; Ruffini, Enrico; Inghirami, Giorgio

    2016-01-01

    Bio-repositories are invaluable resources to implement translational cancer research and clinical programs. They represent one of the most powerful tools for biomolecular studies of clinically annotated cohorts, but high quality samples are required to generate reliable molecular readouts and functional studies. The objective of our study was to define the impact of cancer tissue ischemia time on RNA and DNA quality, and for the generation of Patient-Derived Xenografts (PDXs). One-hundred thirty-five lung cancer specimens were selected among our Institutional BioBank samples. Associations between different warm (surgical) and cold (ex-vivo) ischemia time ranges and RNA quality or PDXs engraftment rates were assessed. RNA quality was determined by RNA integrity number (RINs) values. Fresh viable tissue fragments were implanted subcutaneously in NSG mice and serially transplanted. RNAs with a RIN>7 were detected in 51% of the sample (70/135), with values of RIN significantly lower (OR 0.08, P = 0.01) in samples preserved for more than 3 hours before cryopreservation. Higher quality DNA samples had a concomitant high RIN. Sixty-three primary tumors (41 adenocarcinoma) were implanted with an overall engraftment rate of 33%. Both prolonged warm (>2 hours) and ex-vivo ischemia time (>10 hours) were associated to a lower engraftment rate (OR 0.09 P = 0.01 and OR 0.04 P = 0.008, respectively). RNA quality and PDXs engraftment rate were adversely affected by prolonged ischemia times. Proper tissue collection and processing reduce failure rate. Overall, NSCLC BioBanking represents an innovative modality, which can be successfully executed in routine clinical settings, when stringent Standard Operating Procedures are adopted.

  9. Automated hybrid closed-loop control with a proportional-integral-derivative based system in adolescents and adults with type 1 diabetes: individualizing settings for optimal performance.

    Science.gov (United States)

    Ly, Trang T; Weinzimer, Stuart A; Maahs, David M; Sherr, Jennifer L; Roy, Anirban; Grosman, Benyamin; Cantwell, Martin; Kurtz, Natalie; Carria, Lori; Messer, Laurel; von Eyben, Rie; Buckingham, Bruce A

    2017-08-01

    Automated insulin delivery systems, utilizing a control algorithm to dose insulin based upon subcutaneous continuous glucose sensor values and insulin pump therapy, will soon be available for commercial use. The objective of this study was to determine the preliminary safety and efficacy of initialization parameters with the Medtronic hybrid closed-loop controller by comparing percentage of time in range, 70-180 mg/dL (3.9-10 mmol/L), mean glucose values, as well as percentage of time above and below target range between sensor-augmented pump therapy and hybrid closed-loop, in adults and adolescents with type 1 diabetes. We studied an initial cohort of 9 adults followed by a second cohort of 15 adolescents, using the Medtronic hybrid closed-loop system with the proportional-integral-derivative with insulin feed-back (PID-IFB) algorithm. Hybrid closed-loop was tested in supervised hotel-based studies over 4-5 days. The overall mean percentage of time in range (70-180 mg/dL, 3.9-10 mmol/L) during hybrid closed-loop was 71.8% in the adult cohort and 69.8% in the adolescent cohort. The overall percentage of time spent under 70 mg/dL (3.9 mmol/L) was 2.0% in the adult cohort and 2.5% in the adolescent cohort. Mean glucose values were 152 mg/dL (8.4 mmol/L) in the adult cohort and 153 mg/dL (8.5 mmol/L) in the adolescent cohort. Closed-loop control using the Medtronic hybrid closed-loop system enables adaptive, real-time basal rate modulation. Initializing hybrid closed-loop in clinical practice will involve individualizing initiation parameters to optimize overall glucose control. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Integrated culture platform based on a human platelet lysate supplement for the isolation and scalable manufacturing of umbilical cord matrix-derived mesenchymal stem/stromal cells.

    Science.gov (United States)

    de Soure, António M; Fernandes-Platzgummer, Ana; Moreira, Francisco; Lilaia, Carla; Liu, Shi-Hwei; Ku, Chen-Peng; Huang, Yi-Feng; Milligan, William; Cabral, Joaquim M S; da Silva, Cláudia L

    2017-05-01

    Umbilical cord matrix (UCM)-derived mesenchymal stem/stromal cells (MSCs) are promising therapeutic candidates for regenerative medicine settings. UCM MSCs have advantages over adult cells as these can be obtained through a non-invasive harvesting procedure and display a higher proliferative capacity. However, the high cell doses required in the clinical setting make large-scale manufacturing of UCM MSCs mandatory. A commercially available human platelet lysate-based culture supplement (UltraGRO TM , AventaCell BioMedical) (5%(v/v)) was tested to effectively isolate UCM MSCs and to expand these cells under (1) static conditions, using planar culture systems and (2) stirred culture using plastic microcarriers in a spinner flask. The MSC-like cells were isolated from UCM explant cultures after 11 ± 2 days. After five passages in static culture, UCM MSCs retained their immunophenotype and multilineage differentiation potential. The UCM MSCs cultured under static conditions using UltraGRO TM -supplemented medium expanded more rapidly compared with UCM MSCs expanded using a previously established protocol. Importantly, UCM MSCs were successfully expanded under dynamic conditions on plastic microcarriers using UltraGRO TM -supplemented medium in spinner flasks. Upon an initial 54% cell adhesion to the beads, UCM MSCs expanded by >13-fold after 5-6 days, maintaining their immunophenotype and multilineage differentiation ability. The present paper reports the establishment of an easily scalable integrated culture platform based on a human platelet lysate supplement for the effective isolation and expansion of UCM MSCs in a xenogeneic-free microcarrier-based system. This platform represents an important advance in obtaining safer and clinically meaningful MSC numbers for clinical translation. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  11. EGG: Empirical Galaxy Generator

    Science.gov (United States)

    Schreiber, C.; Elbaz, D.; Pannella, M.; Merlin, E.; Castellano, M.; Fontana, A.; Bourne, N.; Boutsia, K.; Cullen, F.; Dunlop, J.; Ferguson, H. C.; Michałowski, M. J.; Okumura, K.; Santini, P.; Shu, X. W.; Wang, T.; White, C.

    2018-04-01

    The Empirical Galaxy Generator (EGG) generates fake galaxy catalogs and images with realistic positions, morphologies and fluxes from the far-ultraviolet to the far-infrared. The catalogs are generated by egg-gencat and stored in binary FITS tables (column oriented). Another program, egg-2skymaker, is used to convert the generated catalog into ASCII tables suitable for ingestion by SkyMaker (ascl:1010.066) to produce realistic high resolution images (e.g., Hubble-like), while egg-gennoise and egg-genmap can be used to generate the low resolution images (e.g., Herschel-like). These tools can be used to test source extraction codes, or to evaluate the reliability of any map-based science (stacking, dropout identification, etc.).

  12. Empirical P-L-C relations for delta Scuti stars

    International Nuclear Information System (INIS)

    Gupta, S.K.

    1978-01-01

    Separate P-L-C relations have been empirically derived by sampling the delta Scuti stars according to their pulsation modes. The results based on these relations have been compared with those estimated from the model based P-L-C relations and the other existing empirical P-L-C relations. It is found that a separate P-L-C relation for each pulsation mode provides a better correspondence with observations. (Auth.)

  13. Empirical limits to antigravity

    Energy Technology Data Exchange (ETDEWEB)

    Ericson, T.E.O. (European Organization for Nuclear Research, Geneva (CH)); Richter, A. (Technische Hochschule Darmstadt (DE). Inst. fuer Kernphysik)

    1990-02-01

    An upper bound of one part in 10{sup 6}/10{sup 7} is derived for the violation of the equivalence principle for antimatter in the form of antiprotons based on existing data for bulk matter, electrons, positrons, neutrons and protons.

  14. Birds of the Mongol Empire

    OpenAIRE

    Eugene N. Anderson

    2016-01-01

    The Mongol Empire, the largest contiguous empire the world has ever known, had, among other things, a goodly number of falconers, poultry raisers, birdcatchers, cooks, and other experts on various aspects of birding. We have records of this, largely in the Yinshan Zhengyao, the court nutrition manual of the Mongol empire in China (the Yuan Dynasty). It discusses in some detail 22 bird taxa, from swans to chickens. The Huihui Yaofang, a medical encyclopedia, lists ten taxa used medicinally. Ma...

  15. Empirically derived neighbourhood rules for urban land-use modelling

    DEFF Research Database (Denmark)

    Hansen, Henning Sten

    2012-01-01

    Land-use modelling and spatial scenarios have gained attention as a means to meet the challenge of reducing uncertainty in spatial planning and decision making. Many of the recent modelling efforts incorporate cellular automata to accomplish spatially explicit land-use-change modelling. Spatial...

  16. Empirically derived lifespan polytraumatization typologies: A systematic review.

    Science.gov (United States)

    Contractor, Ateka A; Caldas, Stephanie; Fletcher, Shelley; Shea, M Tracie; Armour, Cherie

    2018-07-01

    Polytraumatization classes based on trauma endorsement patterns relate to distinct clinical outcomes. Person-centered approaches robustly evaluate the nature, and construct validity of polytraumatization classes. Our review examined evidence for the nature and construct validity of lifespan polytraumatization typologies. In September 2016, we searched Pubmed, PSYCINFO, PSYC ARTICLES, Academic Search Complete, PILPTS, Web of Science, CINAHL, Medline, PsycEXTRA, and PBSC. Search terms included "latent profile," "latent class," "latent analysis," "person-centered," "polytrauma," "polyvictimization," "traumatization," "lifetime," "cooccurring," "complex," "typology," "multidimensional," "sequential," "multiple," "subtype," "(re)victimization," "cumulative," "maltreatment," "abuse," and "stressor." Inclusionary criteria included: peer-reviewed; latent class/latent profile analyses (LCA/LPA) of lifespan polytrauma classes; adult samples of size greater than 200; only trauma types as LCA/LPA indicators; mental health correlates of typologies; and individual-level trauma assessment. Of 1,397 articles, nine met inclusion criteria. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, research assistants completed a secondary reference search, and independently extracted data with standardized coding forms. Three-class (n = 5) or four-class (n = 4) solutions were found. Seven studies found a class characterized by higher trauma endorsement (high-trauma). All studies found a class characterized by lower trauma endorsement (low-trauma), and predominance of specific traumas (specific-trauma; e.g., childhood maltreatment). High-trauma versus low-trauma classes and specific-trauma versus low-trauma classes differed on mental health correlates. Evidence supports the prevalence of a high-trauma class experiencing poorer mental health, and the detrimental impact of aggregated interpersonal and other traumas. We highlight the clinical importance of addressing polytraumatization classes, and comprehensively assessing the impact of all traumas. © 2018 Wiley Periodicals, Inc.

  17. Economic reasons behind the decline of the Ottoman empire

    OpenAIRE

    Duranoglu, Erkut; Okutucu, Guzide

    2009-01-01

    This study addresses the economic reasons of the decline and fall of the Ottoman Empire. On the contrary to the previous researches, by undertaking both global and domestic developments, the paper examines the decline of the empire from an economical point of perspective. Although international developments such as industrialization in European countries, pressure on the Ottomans in terms of integrating with the world economy, global economic factors like depressions and war...

  18. Empirical techniques in finance

    CERN Document Server

    Bhar, Ramaprasad

    2005-01-01

    This book offers the opportunity to study and experience advanced empi- cal techniques in finance and in general financial economics. It is not only suitable for students with an interest in the field, it is also highly rec- mended for academic researchers as well as the researchers in the industry. The book focuses on the contemporary empirical techniques used in the analysis of financial markets and how these are implemented using actual market data. With an emphasis on Implementation, this book helps foc- ing on strategies for rigorously combing finance theory and modeling technology to extend extant considerations in the literature. The main aim of this book is to equip the readers with an array of tools and techniques that will allow them to explore financial market problems with a fresh perspective. In this sense it is not another volume in eco- metrics. Of course, the traditional econometric methods are still valid and important; the contents of this book will bring in other related modeling topics tha...

  19. Foundations for Psychotherapy Integration

    Directory of Open Access Journals (Sweden)

    António Branco Vasco

    2014-10-01

    Full Text Available The movement for integration in psychotheray is clearly one of the main trends that can be observed in the field. The author stresses three main reasons for this state of affairs and as a way of justifying the importance of integration: historical and psychosocial, empirical and philosophical. A specific way of thinking in integrative terms is also outlined - "paradigmatic complementarity."

  20. Final Empirical Test Case Specification

    DEFF Research Database (Denmark)

    Kalyanova, Olena; Heiselberg, Per

    This document includes the empirical specification on the IEA task of evaluation building energy simulation computer programs for the Double Skin Facades (DSF) constructions. There are two approaches involved into this procedure, one is the comparative approach and another is the empirical one....

  1. Remembrances of Empires Past

    Directory of Open Access Journals (Sweden)

    Robert Aldrich

    2010-03-01

    Full Text Available This paper argues that the colonial legacy is ever present in contemporary Europe. For a generation, most Europeans largely tried, publicly, to forget the colonial past, or remembered it only through the rose-coloured lenses of nostalgia; now the pendulum has swung to memory of that past – even perhaps, in the views of some, to a surfeit of memory, where each group agitates for its own version of history, its own recognition in laws and ceremonies, its own commemoration in museums and monuments, the valorization or repatriation of its own art and artefacts. Word such as ‘invasion,’ ‘racism’ and ‘genocide’ are emotional terms that provoke emotional reactions. Whether leaders should apologize for wrongs of the past – and which wrongs – remains a highly sensitive issue. The ‘return of the colonial’ thus has to do with ethics and politics as well as with history, and can link to statements of apology or recognition, legislation about certain views of history, monetary compensation, repatriation of objects, and—perhaps most importantly—redefinition of national identity and policy. The colonial flags may have been lowered, but many barricades seem to have been raised. Private memories—of loss of land, of unacknowledged service, of political, economic, social and cultural disenfranchisement, but also on the other side of defeat, national castigation and self-flagellation—have been increasingly public. Monuments and museums act not only as sites of history but as venues for political agitation and forums for academic debate – differences of opinion that have spread to the streets. Empire has a long after-life.

  2. Empirical Support for Perceptual Conceptualism

    Directory of Open Access Journals (Sweden)

    Nicolás Alejandro Serrano

    2018-03-01

    Full Text Available The main objective of this paper is to show that perceptual conceptualism can be understood as an empirically meaningful position and, furthermore, that there is some degree of empirical support for its main theses. In order to do this, I will start by offering an empirical reading of the conceptualist position, and making three predictions from it. Then, I will consider recent experimental results from cognitive sciences that seem to point towards those predictions. I will conclude that, while the evidence offered by those experiments is far from decisive, it is enough not only to show that conceptualism is an empirically meaningful position but also that there is empirical support for it.

  3. Empire as a Geopolitical Figure

    DEFF Research Database (Denmark)

    Parker, Noel

    2010-01-01

    This article analyses the ingredients of empire as a pattern of order with geopolitical effects. Noting the imperial form's proclivity for expansion from a critical reading of historical sociology, the article argues that the principal manifestation of earlier geopolitics lay not in the nation...... but in empire. That in turn has been driven by a view of the world as disorderly and open to the ordering will of empires (emanating, at the time of geopolitics' inception, from Europe). One implication is that empires are likely to figure in the geopolitical ordering of the globe at all times, in particular...... after all that has happened in the late twentieth century to undermine nationalism and the national state. Empire is indeed a probable, even for some an attractive form of regime for extending order over the disorder produced by globalisation. Geopolitics articulated in imperial expansion is likely...

  4. A Critical Appraisal of Peter Gowan’s “Contemporary Intra-Core Relations and World-Systems Theory”: A Capitalist World-Empire or U.S.-East Asian Geo-Economic Integration?

    Directory of Open Access Journals (Sweden)

    John Gulick

    2015-08-01

    Full Text Available This paper evaluates Peter Gowan’s musings on the topic of a U.S.-centered “capitalist world-empire.” Gowan’s heterodox concept of a “capitalist world-empire” is intellectually defensible. And his claim that U.S. hegemony is historically unique, because unlike previous dominant powers the U.S. has been able to distinctly mold the accumulation regimes and security environments of its would-be rivals in the core, is more than convincing. However, Gowan tends to overstate the degree to which the U.S. in the 1990’s enjoyed a productive sector revival, rather than a mere super-inflation of dollar-denominated assets. This tendency prevents him from anticipating just how summarily the U.S. would ditch consensual approaches to managing the capitalistworld-economy once the Wall Street bubble collapsed, and hence from appreciating just how fed up Western European and East Asian elites would become with the predatory character of U.S. hegemony in decay. In conclusion the paper argues that while the U.S. may have neither the resources nor the credibility to politically control the global division of labor, something akin to a U.S.-East Asian geo-economic bloc may be in the process of forming. This is so because the Chinese and Japanese economic growth models remain wedded to the underwriting of the U.S.’ seigniorage privileges', and because past and present frictions between China and Japan stand in the way of tighter Sino-Japanese political coordination.

  5. Assimilation of SMOS-derived soil moisture in a fully integrated hydrological and soil-vegetation-atmosphere transfer model in Western Denmark

    DEFF Research Database (Denmark)

    Ridler, Marc-Etienne Francois; Madsen, Henrik; Stisen, Simon

    2014-01-01

    -derived soil moisture assimilation in a catchment scale model is typically restricted by two challenges: (1) passive microwave is too coarse for direct assimilation and (2) the data tend to be biased. The solution proposed in this study is to disaggregate the SMOS bias using a higher resolution land cover...... classification map that was derived from Landsat thermal images. Using known correlations between SMOS bias and vegetation type, the assimilation filter is adapted to calculate biases online, using an initial bias estimate. Real SMOS-derived soil moisture is assimilated in a precalibrated catchment model...

  6. The use of moral deliberation in empirical research in bioethics

    Directory of Open Access Journals (Sweden)

    Elma Zoboli

    2016-10-01

    Full Text Available The article presents an integrated empirical ethics research project that used the moral deliberation, according to the theoretical and philosophical conception, and methodical proposal of Diego Gracia, as a theoretical and methodological framework. The application showed the potential to realize the dynamics of the studied object in real life, making it possible, from the situation presented in the vignettes, for participants to include what they considered for dealing with the conflict of values. It also made the integration of philosophical and empirical approaches in bioethics research possible. The analytical category of prudence allowed the results to be assessed in a critical and comprehensive way.

  7. Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure to silver nanoparticles.

    Science.gov (United States)

    Oh, Jung-Hwa; Son, Mi-Young; Choi, Mi-Sun; Kim, Soojin; Choi, A-Young; Lee, Hyang-Ae; Kim, Ki-Suk; Kim, Janghwan; Song, Chang Woo; Yoon, Seokjoo

    2016-05-15

    Given the rapid growth of engineered and customer products made of silver nanoparticles (Ag NPs), understanding their biological and toxicological effects on humans is critically important. The molecular developmental neurotoxic effects associated with exposure to Ag NPs were analyzed at the physiological and molecular levels, using an alternative cell model: human embryonic stem cell (hESC)-derived neural stem/progenitor cells (NPCs). In this study, the cytotoxic effects of Ag NPs (10-200μg/ml) were examined in these hESC-derived NPCs, which have a capacity for neurogenesis in vitro, at 6 and 24h. The results showed that Ag NPs evoked significant toxicity in hESC-derived NPCs at 24h in a dose-dependent manner. In addition, Ag NPs induced cell cycle arrest and apoptosis following a significant increase in oxidative stress in these cells. To further clarify the molecular mechanisms of the toxicological effects of Ag NPs at the transcriptional and post-transcriptional levels, the global expression profiles of genes and miRNAs were analyzed in hESC-derived NPCs after Ag NP exposure. The results showed that Ag NPs induced oxidative stress and dysfunctional neurogenesis at the molecular level in hESC-derived NPCs. Based on this hESC-derived neural cell model, these findings have increased our understanding of the molecular events underlying developmental neurotoxicity induced by Ag NPs in humans. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. Integrating effective drought index (EDI) and remote sensing derived parameters for agricultural drought assessment and prediction in Bundelkhand region of India

    Science.gov (United States)

    Padhee, S. K.; Nikam, B. R.; Aggarwal, S. P.; Garg, V.

    2014-11-01

    Drought is an extreme condition due to moisture deficiency and has adverse effect on society. Agricultural drought occurs when restraining soil moisture produces serious crop stress and affects the crop productivity. The soil moisture regime of rain-fed agriculture and irrigated agriculture behaves differently on both temporal and spatial scale, which means the impact of meteorologically and/or hydrological induced agriculture drought will be different in rain-fed and irrigated areas. However, there is a lack of agricultural drought assessment system in Indian conditions, which considers irrigated and rain-fed agriculture spheres as separate entities. On the other hand recent advancements in the field of earth observation through different satellite based remote sensing have provided researchers a continuous monitoring of soil moisture, land surface temperature and vegetation indices at global scale, which can aid in agricultural drought assessment/monitoring. Keeping this in mind, the present study has been envisaged with the objective to develop agricultural drought assessment and prediction technique by spatially and temporally assimilating effective drought index (EDI) with remote sensing derived parameters. The proposed technique takes in to account the difference in response of rain-fed and irrigated agricultural system towards agricultural drought in the Bundelkhand region (The study area). The key idea was to achieve the goal by utilizing the integrated scenarios from meteorological observations and soil moisture distribution. EDI condition maps were prepared from daily precipitation data recorded by Indian Meteorological Department (IMD), distributed within the study area. With the aid of frequent MODIS products viz. vegetation indices (VIs), and land surface temperature (LST), the coarse resolution soil moisture product from European Space Agency (ESA) were downscaled using linking model based on Triangle method to a finer resolution soil moisture product

  9. Birds of the Mongol Empire

    Directory of Open Access Journals (Sweden)

    Eugene N. Anderson

    2016-09-01

    Full Text Available The Mongol Empire, the largest contiguous empire the world has ever known, had, among other things, a goodly number of falconers, poultry raisers, birdcatchers, cooks, and other experts on various aspects of birding. We have records of this, largely in the Yinshan Zhengyao, the court nutrition manual of the Mongol empire in China (the Yuan Dynasty. It discusses in some detail 22 bird taxa, from swans to chickens. The Huihui Yaofang, a medical encyclopedia, lists ten taxa used medicinally. Marco Polo also made notes on Mongol bird use. There are a few other records. This allows us to draw conclusions about Mongol ornithology, which apparently was sophisticated and detailed.

  10. Empirically characteristic analysis of chaotic PID controlling particle swarm optimization.

    Science.gov (United States)

    Yan, Danping; Lu, Yongzhong; Zhou, Min; Chen, Shiping; Levy, David

    2017-01-01

    Since chaos systems generally have the intrinsic properties of sensitivity to initial conditions, topological mixing and density of periodic orbits, they may tactfully use the chaotic ergodic orbits to achieve the global optimum or their better approximation to given cost functions with high probability. During the past decade, they have increasingly received much attention from academic community and industry society throughout the world. To improve the performance of particle swarm optimization (PSO), we herein propose a chaotic proportional integral derivative (PID) controlling PSO algorithm by the hybridization of chaotic logistic dynamics and hierarchical inertia weight. The hierarchical inertia weight coefficients are determined in accordance with the present fitness values of the local best positions so as to adaptively expand the particles' search space. Moreover, the chaotic logistic map is not only used in the substitution of the two random parameters affecting the convergence behavior, but also used in the chaotic local search for the global best position so as to easily avoid the particles' premature behaviors via the whole search space. Thereafter, the convergent analysis of chaotic PID controlling PSO is under deep investigation. Empirical simulation results demonstrate that compared with other several chaotic PSO algorithms like chaotic PSO with the logistic map, chaotic PSO with the tent map and chaotic catfish PSO with the logistic map, chaotic PID controlling PSO exhibits much better search efficiency and quality when solving the optimization problems. Additionally, the parameter estimation of a nonlinear dynamic system also further clarifies its superiority to chaotic catfish PSO, genetic algorithm (GA) and PSO.

  11. Differential Effects of High-Protein Diets Derived from Soy and Casein on Blood–Brain Barrier Integrity in Wild-type Mice

    OpenAIRE

    Matthew Snelson; Matthew Snelson; John C. L. Mamo; John C. L. Mamo; Virginie Lam; Virginie Lam; Corey Giles; Corey Giles; Ryusuke Takechi; Ryusuke Takechi

    2017-01-01

    A number of studies report that a diet high in protein influences cognitive performance, but the results are inconsistent. Studies demonstrated that protein from different food sources has differential effects on cognition. It is increasingly recognized that the integrity of cerebrovascular blood–brain barrier (BBB) is pivotal for central nervous system function. However, to date, no studies have reported the effects of high-protein diets on BBB integrity. Therefore, in this study, the effect...

  12. Mapping sediment thickness of Islamabad city using empirical ...

    Indian Academy of Sciences (India)

    A number of studies in recent years have demonstrated that frequency and ... sediment thicknesses derived from empirical relations developed in this study with ... Location map of the study area, the bold light grey line shows the boundary of the Islamabad region. .... frequency disturbances (wind blowing, in case of near tall ...

  13. The primal integrated realm and the derived interactive realm in relation to biosemiosis, and their link with the ideas of J.W. von Goethe.

    Science.gov (United States)

    Barlow, Peter W

    2012-09-01

    Certain phenomena in Nature which might logically be regarded as indicating biosemiotic communication, with signal, receptor and interpretant, may, in fact, indicate no such thing. Instead, the respective phenomenological observations may point to an underlying system that JW von Goethe termed an "Urphänomen". From such Primal Phenomena emerge derived phenomena, or "Types", which are made substantial by processes that uniquely define Life and Living. Biosemiosis arises and takes place within the derived Types. Examples of Primal Phenomena and their derivatives are taken from recent observations on the putative influence of the lunisolar gravitational force upon animal and plant behavior, and from some aspects of plant development that show connection with Goethe's idea of the 'Urpflanze'.

  14. Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure to silver nanoparticles

    International Nuclear Information System (INIS)

    Oh, Jung-Hwa; Son, Mi-Young; Choi, Mi-Sun; Kim, Soojin; Choi, A-young; Lee, Hyang-Ae; Kim, Ki-Suk; Kim, Janghwan; Song, Chang Woo; Yoon, Seokjoo

    2016-01-01

    Given the rapid growth of engineered and customer products made of silver nanoparticles (Ag NPs), understanding their biological and toxicological effects on humans is critically important. The molecular developmental neurotoxic effects associated with exposure to Ag NPs were analyzed at the physiological and molecular levels, using an alternative cell model: human embryonic stem cell (hESC)-derived neural stem/progenitor cells (NPCs). In this study, the cytotoxic effects of Ag NPs (10–200 μg/ml) were examined in these hESC-derived NPCs, which have a capacity for neurogenesis in vitro, at 6 and 24 h. The results showed that Ag NPs evoked significant toxicity in hESC-derived NPCs at 24 h in a dose-dependent manner. In addition, Ag NPs induced cell cycle arrest and apoptosis following a significant increase in oxidative stress in these cells. To further clarify the molecular mechanisms of the toxicological effects of Ag NPs at the transcriptional and post-transcriptional levels, the global expression profiles of genes and miRNAs were analyzed in hESC-derived NPCs after Ag NP exposure. The results showed that Ag NPs induced oxidative stress and dysfunctional neurogenesis at the molecular level in hESC-derived NPCs. Based on this hESC-derived neural cell model, these findings have increased our understanding of the molecular events underlying developmental neurotoxicity induced by Ag NPs in humans. - Highlights: • This system served as a suitable model for developmental neurotoxicity testing. • Ag NPs induce the apoptosis in human neural cells by ROS generation. • Genes for development of neurons were dysregulated in response to Ag NPs. • Molecular events during early developmental neurotoxicity were proposed.

  15. Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure to silver nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Jung-Hwa [Korea Institute of Toxicology (KIT), Daejeon 34114 (Korea, Republic of); Department of human and environmental toxicology, University of Science & Technology, Daejeon 34113 (Korea, Republic of); Son, Mi-Young [Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahangno, Yuseong-gu, Daejeon 34141 (Korea, Republic of); Department of functional genomics, University of Science & Technology, 217 Gajungro, Yuseong-gu, Daejeon 34113 (Korea, Republic of); Choi, Mi-Sun; Kim, Soojin; Choi, A-young [Korea Institute of Toxicology (KIT), Daejeon 34114 (Korea, Republic of); Lee, Hyang-Ae; Kim, Ki-Suk [Korea Institute of Toxicology (KIT), Daejeon 34114 (Korea, Republic of); Department of human and environmental toxicology, University of Science & Technology, Daejeon 34113 (Korea, Republic of); Kim, Janghwan [Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahangno, Yuseong-gu, Daejeon 34141 (Korea, Republic of); Department of functional genomics, University of Science & Technology, 217 Gajungro, Yuseong-gu, Daejeon 34113 (Korea, Republic of); Song, Chang Woo, E-mail: cwsong@kitox.re.kr [Korea Institute of Toxicology (KIT), Daejeon 34114 (Korea, Republic of); Department of human and environmental toxicology, University of Science & Technology, Daejeon 34113 (Korea, Republic of); Yoon, Seokjoo, E-mail: sjyoon@kitox.re.kr [Korea Institute of Toxicology (KIT), Daejeon 34114 (Korea, Republic of); Department of human and environmental toxicology, University of Science & Technology, Daejeon 34113 (Korea, Republic of)

    2016-05-15

    Given the rapid growth of engineered and customer products made of silver nanoparticles (Ag NPs), understanding their biological and toxicological effects on humans is critically important. The molecular developmental neurotoxic effects associated with exposure to Ag NPs were analyzed at the physiological and molecular levels, using an alternative cell model: human embryonic stem cell (hESC)-derived neural stem/progenitor cells (NPCs). In this study, the cytotoxic effects of Ag NPs (10–200 μg/ml) were examined in these hESC-derived NPCs, which have a capacity for neurogenesis in vitro, at 6 and 24 h. The results showed that Ag NPs evoked significant toxicity in hESC-derived NPCs at 24 h in a dose-dependent manner. In addition, Ag NPs induced cell cycle arrest and apoptosis following a significant increase in oxidative stress in these cells. To further clarify the molecular mechanisms of the toxicological effects of Ag NPs at the transcriptional and post-transcriptional levels, the global expression profiles of genes and miRNAs were analyzed in hESC-derived NPCs after Ag NP exposure. The results showed that Ag NPs induced oxidative stress and dysfunctional neurogenesis at the molecular level in hESC-derived NPCs. Based on this hESC-derived neural cell model, these findings have increased our understanding of the molecular events underlying developmental neurotoxicity induced by Ag NPs in humans. - Highlights: • This system served as a suitable model for developmental neurotoxicity testing. • Ag NPs induce the apoptosis in human neural cells by ROS generation. • Genes for development of neurons were dysregulated in response to Ag NPs. • Molecular events during early developmental neurotoxicity were proposed.

  16. Empirical Legality and Effective Reality

    Directory of Open Access Journals (Sweden)

    Hernán Pringe

    2015-08-01

    Full Text Available The conditions that Kant’s doctrine establishes are examined for the predication of the effective reality of certain empirical objects. It is maintained that a for such a predication, it is necessary to have not only perception but also a certain homogeneity of sensible data, and b the knowledge of the existence of certain empirical objects depends on the application of regulative principles of experience.

  17. Empirical logic and quantum mechanics

    International Nuclear Information System (INIS)

    Foulis, D.J.; Randall, C.H.

    1976-01-01

    This article discusses some of the basic notions of quantum physics within the more general framework of operational statistics and empirical logic (as developed in Foulis and Randall, 1972, and Randall and Foulis, 1973). Empirical logic is a formal mathematical system in which the notion of an operation is primitive and undefined; all other concepts are rigorously defined in terms of such operations (which are presumed to correspond to actual physical procedures). (Auth.)

  18. Empirical Research In Engineering Design

    DEFF Research Database (Denmark)

    Ahmed, Saeema

    2007-01-01

    Increasingly engineering design research involves the use of empirical studies that are conducted within an industrial environment [Ahmed, 2001; Court 1995; Hales 1987]. Research into the use of information by designers or understanding how engineers build up experience are examples of research...... of research issues. This paper describes case studies of empirical research carried out within industry in engineering design focusing upon information, knowledge and experience in engineering design. The paper describes the research methods employed, their suitability for the particular research aims...

  19. Integrating global satellite-derived data products as a pre-analysis for hydrological modelling studies : a case study for the Red River Basin

    NARCIS (Netherlands)

    Simons, G.W.H.; Bastiaanssen, W.G.M.; Ngô, L.A.; Hain, C.R.; Anderson, M.; Senay, G.

    2016-01-01

    With changes in weather patterns and intensifying anthropogenic water use, there is an increasing need for spatio-temporal information on water fluxes and stocks in river basins. The assortment of satellite-derived open-access information sources on rainfall (P) and land use/land cover (LULC) is

  20. Navigating Instructional Dialectics: Empirical Exploration of Paradox in Teaching

    Science.gov (United States)

    Thompson, Blair; Rudick, C. Kyle; Kerssen-Griep, Jeff; Golsan, Kathryn

    2018-01-01

    Navigating contradiction represents an integral part of the teaching process. While educational literature has discussed the paradoxes that teachers experience in the classroom, minimal empirical research has analyzed the strategies teachers employ to address these paradoxes. Using relational dialectics as a theoretical framework for understanding…

  1. Uniform convergence of the empirical spectral distribution function

    NARCIS (Netherlands)

    Mikosch, T; Norvaisa, R

    1997-01-01

    Let X be a linear process having a finite fourth moment. Assume F is a class of square-integrable functions. We consider the empirical spectral distribution function J(n,X) based on X and indexed by F. If F is totally bounded then J(n,X) satisfies a uniform strong law of large numbers. If, in

  2. Integrating Global Satellite-Derived Data Products as a Pre-Analysis for Hydrological Modelling Studies: A Case Study for the Red River Basin

    Directory of Open Access Journals (Sweden)

    Gijs Simons

    2016-03-01

    Full Text Available With changes in weather patterns and intensifying anthropogenic water use, there is an increasing need for spatio-temporal information on water fluxes and stocks in river basins. The assortment of satellite-derived open-access information sources on rainfall (P and land use/land cover (LULC is currently being expanded with the application of actual evapotranspiration (ETact algorithms on the global scale. We demonstrate how global remotely sensed P and ETact datasets can be merged to examine hydrological processes such as storage changes and streamflow prior to applying a numerical simulation model. The study area is the Red River Basin in China in Vietnam, a generally challenging basin for remotely sensed information due to frequent cloud cover. Over this region, several satellite-based P and ETact products are compared, and performance is evaluated using rain gauge records and longer-term averaged streamflow. A method is presented for fusing multiple satellite-derived ETact estimates to generate an ensemble product that may be less susceptible, on a global basis, to errors in individual modeling approaches. Subsequently, monthly satellite-derived rainfall and ETact are combined to assess the water balance for individual subcatchments and types of land use, defined using a global land use classification improved based on auxiliary satellite data. It was found that a combination of TRMM rainfall and the ensemble ETact product is consistent with streamflow records in both space and time. It is concluded that monthly storage changes, multi-annual streamflow and water yield per LULC type in the Red River Basin can be successfully assessed based on currently available global satellite-derived products.

  3. Semi-empirical model for optimising future heavy-ion luminosity of the LHC

    CERN Document Server

    Schaumann, M

    2014-01-01

    The wide spectrum of intensities and emittances imprinted on the LHC Pb bunches during the accumulation of bunch trains in the injector chain result in a significant spread in the single bunch luminosities and lifetimes in collision. Based on the data collected in the 2011 Pb-Pb run, an empirical model is derived to predict the single-bunch peak luminosity depending on the bunch’s position within the beam. In combination with this model, simulations of representative bunches are used to estimate the luminosity evolution for the complete ensemble of bunches. Several options are being considered to improve the injector performance and to increase the number of bunches in the LHC, leading to several potential injection scenarios, resulting in different peak and integrated luminosities. The most important options for after the long shutdown (LS) 1 and 2 are evaluated and compared.

  4. Global Derivatives

    DEFF Research Database (Denmark)

    Andersen, Torben Juul

    approaches to dealing in the global business environment." - Sharon Brown-Hruska, Commissioner, Commodity Futures Trading Commission, USA. "This comprehensive survey of modern risk management using derivative securities is a fine demonstration of the practical relevance of modern derivatives theory to risk......" provides comprehensive coverage of different types of derivatives, including exchange traded contracts and over-the-counter instruments as well as real options. There is an equal emphasis on the practical application of derivatives and their actual uses in business transactions and corporate risk...... management situations. Its key features include: derivatives are introduced in a global market perspective; describes major derivative pricing models for practical use, extending these principles to valuation of real options; practical applications of derivative instruments are richly illustrated...

  5. Improving an Empirical Formula for the Absorption of Sound in the Sea

    National Research Council Canada - National Science Library

    Moll, C. A. van; Ainslie, M. A; Janmaat, J

    2008-01-01

    A new empirical formula for the absorption of sound in seawater is derived. The starting point of this investigation is the formula proposed by Ainslie and McColm for attenuation due to the boron and magnesium relaxations...

  6. Umayyad Relations with Byzantium Empire

    Directory of Open Access Journals (Sweden)

    Mansoor Haidari

    2017-06-01

    Full Text Available This research investigates the political and military relations between Umayyad caliphates with the Byzantine Empire. The aim of this research is to clarify Umayyad caliphate’s relations with the Byzantine Empire. We know that these relations were mostly about war and fight. Because there were always intense conflicts between Muslims and the Byzantine Empire, they had to have an active continuous diplomacy to call truce and settle the disputes. Thus, based on the general policy of the Umayyad caliphs, Christians were severely ignored and segregated within Islamic territories. This segregation of the Christians was highly affected by political relationships. It is worthy of mentioning that Umayyad caliphs brought the governing style of the Sassanid kings and Roman Caesar into the Islamic Caliphate system but they didn’t establish civil institutions and administrative organizations.

  7. Relationships between rating-of-perceived-exertion- and heart-rate-derived internal training load in professional soccer players: a comparison of on-field integrated training sessions.

    Science.gov (United States)

    Campos-Vazquez, Miguel Angel; Mendez-Villanueva, Alberto; Gonzalez-Jurado, Jose Antonio; León-Prados, Juan Antonio; Santalla, Alfredo; Suarez-Arrones, Luis

    2015-07-01

    To describe the internal training load (ITL) of common training sessions performed during a typical week and to determine the relationships between different indicators of ITL commonly employed in professional football (soccer). Session-rating-of-perceived-exertion TL (sRPE-TL) and heart-rate- (HR) derived measurements of ITL as Edwards TL and Stagno training impulses (TRIMPMOD) were used in 9 players during 3 periods of the season. The relationships between them were analyzed in different training sessions during a typical week: skill drills/circuit training + small-sided games (SCT+SSGs), ball-possession games+technical-tactical exercises (BPG+TTE), tactical training (TT), and prematch activation (PMa). HR values obtained during SCT+SSGs and BPG+TTE were substantially greater than those in the other 2 sessions, all the ITL markers and session duration were substantially greater in SCT+SSGs than in any other session, and all ITL measures in BPG+TTE were substantially greater than in TT and PMa sessions. Large relationships were found between HR>80% HRmax and HR>90% HRmax vs sRPE-TL during BPG+TTE and TT sessions (r=.61-.68). Very large relationships were found between Edwards TL and sRPE-TL and between TRIMPMOD and sRPE-TL in sessions with BPG+TTE and TT (r=.73-.87). Correlations between the different HR-based methods were always extremely large (r=.92-.98), and unclear correlations were observed for other relationships between variables. sRPE-TL provided variable-magnitude within-individual correlations with HR-derived measures of training intensity and load during different types of training sessions typically performed during a week in professional soccer. Caution should be applied when using RPE- or HR-derived measures of exercise intensity/load in soccer training interchangeably.

  8. 'Nobody tosses a dwarf!' The relation between the empirical and the normative reexamined.

    Science.gov (United States)

    Leget, Carlo; Borry, Pascal; de Vries, Raymond

    2009-05-01

    This article discusses the relation between empirical and normative approaches in bioethics. The issue of dwarf tossing, while admittedly unusual, is chosen as a point of departure because it challenges the reader to look with fresh eyes upon several central bioethical themes, including human dignity, autonomy, and the protection of vulnerable people. After an overview of current approaches to the integration of empirical and normative ethics, we consider five ways that the empirical and normative can be brought together to speak to the problem of dwarf tossing: prescriptive applied ethics, theoretical ethics, critical applied ethics, particularist ethics and integrated empirical ethics. We defend a position of critical applied ethics that allows for a two-way relation between empirical and normative theories. Against efforts fully to integrate the normative and the empirical into one synthesis, we propose that the two should stand in tension and relation to one another. The approach we endorse acknowledges that a social practice can and should be judged both by the gathering of empirical data and by normative ethics. Critical applied ethics uses a five stage process that includes: (a) determination of the problem, (b) description of the problem, (c) empirical study of effects and alternatives, (d) normative weighing and (e) evaluation of the effects of a decision. In each stage, we explore the perspective from both the empirical (sociological) and the normative ethical point of view. We conclude by applying our five-stage critical applied ethics to the example of dwarf tossing.

  9. Financial Derivatives

    DEFF Research Database (Denmark)

    Wigan, Duncan

    2013-01-01

    Contemporary derivatives mark the development of capital and constitute a novel form of ownership. By reconfiguring the temporal, spatial and legal character of ownership derivatives present a substantive challenge to the tax collecting state. While fiscal systems are nationally bounded...... and inherently static, capital itself is unprecedentedly mobile, fluid and fungible. As such derivatives raise the specter of ‘financial weapons of mass destruction’....

  10. Financial Derivatives

    OpenAIRE

    Janečková, Alena

    2011-01-01

    1 Abstract/ Financial derivatives The purpose of this thesis is to provide an introduction to financial derivatives which has been, from the legal perspective, described in a not satisfactory manner as quite little literature that can be found about this topic. The main objectives of this thesis are to define the term "financial derivatives" and its particular types and to analyse legal nature of these financial instruments. The last objective is to try to draft future law regulation of finan...

  11. Gazprom the new russian empire

    International Nuclear Information System (INIS)

    Cosnard, D.

    2004-01-01

    The author analyzes the economical and political impacts of the great Gazprom group, leader in the russian energy domain, in Russia. Already number one of the world gas industry, this Group is becoming the right-hand of the Kremlin. Thus the author wonders on this empire transparency and limits. (A.L.B.)

  12. Phenomenology and the Empirical Turn

    NARCIS (Netherlands)

    Zwier, Jochem; Blok, Vincent; Lemmens, Pieter

    2016-01-01

    This paper provides a phenomenological analysis of postphenomenological philosophy of technology. While acknowledging that the results of its analyses are to be recognized as original, insightful, and valuable, we will argue that in its execution of the empirical turn, postphenomenology forfeits

  13. Empirical ethics as dialogical practice

    NARCIS (Netherlands)

    Widdershoven, G.A.M.; Abma, T.A.; Molewijk, A.C.

    2009-01-01

    In this article, we present a dialogical approach to empirical ethics, based upon hermeneutic ethics and responsive evaluation. Hermeneutic ethics regards experience as the concrete source of moral wisdom. In order to gain a good understanding of moral issues, concrete detailed experiences and

  14. Teaching "Empire of the Sun."

    Science.gov (United States)

    Riet, Fred H. van

    1990-01-01

    A Dutch teacher presents reading, film viewing, and writing activities for "Empire of the Sun," J. G. Ballard's autobiographical account of life as a boy in Shanghai and in a Japanese internment camp during World War II (the subject of Steven Spielberg's film of the same name). Includes objectives, procedures, and several literature,…

  15. Empirical Specification of Utility Functions.

    Science.gov (United States)

    Mellenbergh, Gideon J.

    Decision theory can be applied to four types of decision situations in education and psychology: (1) selection; (2) placement; (3) classification; and (4) mastery. For the application of the theory, a utility function must be specified. Usually the utility function is chosen on a priori grounds. In this paper methods for the empirical assessment…

  16. Empirical Productivity Indices and Indicators

    NARCIS (Netherlands)

    B.M. Balk (Bert)

    2016-01-01

    textabstractThe empirical measurement of productivity change (or difference) by means of indices and indicators starts with the ex post profit/loss accounts of a production unit. Key concepts are profit, leading to indicators, and profitability, leading to indices. The main task for the productivity

  17. EMPIRICAL RESEARCH AND CONGREGATIONAL ANALYSIS ...

    African Journals Online (AJOL)

    empirical research has made to the process of congregational analysis. 1 Part of this ... contextual congegrational analysis – meeting social and divine desires”) at the IAPT .... methodology of a congregational analysis should be regarded as a process. ... essential to create space for a qualitative and quantitative approach.

  18. Empirical processes: theory and applications

    OpenAIRE

    Venturini Sergio

    2005-01-01

    Proceedings of the 2003 Summer School in Statistics and Probability in Torgnon (Aosta, Italy) held by Prof. Jon A. Wellner and Prof. M. Banerjee. The topic presented was the theory of empirical processes with applications to statistics (m-estimation, bootstrap, semiparametric theory).

  19. Empirical laws, regularity and necessity

    NARCIS (Netherlands)

    Koningsveld, H.

    1973-01-01

    In this book I have tried to develop an analysis of the concept of an empirical law, an analysis that differs in many ways from the alternative analyse's found in contemporary literature dealing with the subject.

    1 am referring especially to two well-known views, viz. the regularity and

  20. Empirical analysis of consumer behavior

    NARCIS (Netherlands)

    Huang, Yufeng

    2015-01-01

    This thesis consists of three essays in quantitative marketing, focusing on structural empirical analysis of consumer behavior. In the first essay, he investigates the role of a consumer's skill of product usage, and its imperfect transferability across brands, in her product choice. It shows that

  1. Differential Effects of High-Protein Diets Derived from Soy and Casein on Blood–Brain Barrier Integrity in Wild-type Mice

    Directory of Open Access Journals (Sweden)

    Matthew Snelson

    2017-07-01

    Full Text Available A number of studies report that a diet high in protein influences cognitive performance, but the results are inconsistent. Studies demonstrated that protein from different food sources has differential effects on cognition. It is increasingly recognized that the integrity of cerebrovascular blood–brain barrier (BBB is pivotal for central nervous system function. However, to date, no studies have reported the effects of high-protein diets on BBB integrity. Therefore, in this study, the effects of diets enriched in casein or soy protein on BBB permeability were investigated. Immunomicroscopy analyses of cerebral parenchymal immunoglobulin G extravasation indicated significant BBB disruption in the cortex of young adult mice maintained on high-casein diet for 12 weeks, while no signs of BBB dysfunction were observed in mice fed with control or high-soy protein diet. Moreover, cortical expression of glial fibrillary acidic protein (GFAP was significantly greater in mice fed the high-casein diet compared to control mice, indicating heightened astrocyte activation, whereas mice maintained on a soy-enriched diet showed no increase of GFAP abundance. Plasma concentrations of homocysteine were markedly greater in mice maintained on a high-casein diet in comparison to control mice. Collectively, these findings suggest that a diet enriched in casein but not soy protein may induce astrocyte activation through exaggerated BBB permeability by increased plasma homocysteine. The outcomes indicate the differential effects of protein sources on BBB and neuroinflammation, which may provide an important implication for dietary guidelines for protein supplementation.

  2. Integrated chemical sensor array platform based on a light emitting diode, xerogel-derived sensor elements, and high-speed pin printing

    International Nuclear Information System (INIS)

    Cho, Eun Jeong; Bright, Frank V.

    2002-01-01

    We report a new, solid-state, integrated optical array sensor platform. By using pin printing technology in concert with sol-gel-processing methods, we form discrete xerogel-based microsensor elements that are on the order of 100 μm in diameter and 1 μm thick directly on the face of a light emitting diode (LED). The LED serves as the light source to excite chemically responsive luminophores sequestered within the doped xerogel microsensors and the analyte-dependent emission from within the doped xerogel is detected with a charge coupled device (CCD). We overcome the problem of background illumination from the LED reaching the CCD and the associated biasing that results by coating the LED first with a thin layer of blue paint. The thin paint layer serves as an optical filter, knocking out the LEDs red-edge spectral tail. The problem of the spatially-dependent fluence across the LED face is solved entirely by performing ratiometric measurements. We illustrate the performance of the new sensor scheme by forming an array of 100 discrete O 2 -responsive sensing elements on the face of a single LED. The combination of pin printing with an integrated sensor and light source platform results in a rapid method of forming (∼1 s per sensor element) reusable sensor arrays. The entire sensor array can be calibrated using just one sensor element. Array-to-array reproducibly is <8%. Arrays can be formed using single or multiple pins with indistinguishable analytical performance

  3. Energy use and carbon footprints differ dramatically for diverse wastewater-derived carbonaceous substrates: An integrated exploration of biokinetics and life-cycle assessment.

    Science.gov (United States)

    Li, Yanbo; Wang, Xu; Butler, David; Liu, Junxin; Qu, Jiuhui

    2017-03-21

    Energy neutrality and reduction of carbon emissions are significant challenges to the enhanced sustainability of wastewater treatment plants (WWTPs). Harvesting energy from wastewater carbonaceous substrates can offset energy demands and enable net power generation; yet, there is limited research about how carbonaceous substrates influence energy and carbon implications of WWTPs with integrated energy recovery at systems-level. Consequently, this research uses biokinetics modelling and life cycle assessment philology to explore this notion, by tracing and assessing the quantitative flows of energy embodied or captured, and by exploring the carbon footprint throughout an energy-intensive activated sludge process with integrated energy recovery facilities. The results indicate that energy use and carbon footprint per cubic meter of wastewater treated, varies markedly with the carbon substrate. Compared with systems driven with proteins, carbohydrates or other short-chain fatty acids, systems fed with acetic acid realized energy neutrality with maximal net gain of power from methane combustion (0.198 kWh) and incineration of residual biosolids (0.153 kWh); and also achieved a negative carbon footprint (72.6 g CO 2 ). The findings from this work help us to better understand and develop new technical schemes for improving the energy efficiency of WWTPs by repurposing the stream of carbon substrates across systems.

  4. Generalized empirical likelihood methods for analyzing longitudinal data

    KAUST Repository

    Wang, S.

    2010-02-16

    Efficient estimation of parameters is a major objective in analyzing longitudinal data. We propose two generalized empirical likelihood based methods that take into consideration within-subject correlations. A nonparametric version of the Wilks theorem for the limiting distributions of the empirical likelihood ratios is derived. It is shown that one of the proposed methods is locally efficient among a class of within-subject variance-covariance matrices. A simulation study is conducted to investigate the finite sample properties of the proposed methods and compare them with the block empirical likelihood method by You et al. (2006) and the normal approximation with a correctly estimated variance-covariance. The results suggest that the proposed methods are generally more efficient than existing methods which ignore the correlation structure, and better in coverage compared to the normal approximation with correctly specified within-subject correlation. An application illustrating our methods and supporting the simulation study results is also presented.

  5. Sugar sensing by ChREBP/Mondo-Mlx-new insight into downstream regulatory networks and integration of nutrient-derived signals.

    Science.gov (United States)

    Havula, Essi; Hietakangas, Ville

    2018-04-01

    Animals regulate their physiology with respect to nutrient status, which requires nutrient sensing pathways. Simple carbohydrates, sugars, are sensed by the basic-helix-loop-helix leucine zipper transcription factors ChREBP/Mondo, together with their heterodimerization partner Mlx, which are well-established activators of sugar-induced lipogenesis. Loss of ChREBP/Mondo-Mlx in mouse and Drosophila leads to sugar intolerance, that is, inability to survive on sugar containing diet. Recent evidence has revealed that ChREBP/Mondo-Mlx responds to sugar and fatty acid-derived metabolites through several mechanisms and cross-connects with other nutrient sensing pathways. ChREBP/Mondo-Mlx controls several downstream transcription factors and hormones, which mediate not only readjustment of metabolic pathways, but also control feeding behavior, intestinal digestion, and circadian rhythm. Copyright © 2017. Published by Elsevier Ltd.

  6. A systematic evaluation of integration free reprogramming methods for deriving clinically relevant patient specific induced pluripotent stem (iPS cells.

    Directory of Open Access Journals (Sweden)

    Pollyanna A Goh

    Full Text Available A systematic evaluation of three different methods for generating induced pluripotent stem (iPS cells was performed using the same set of parental cells in our quest to develop a feeder independent and xeno-free method for somatic cell reprogramming that could be transferred into a GMP environment. When using the BJ fibroblast cell line, the highest reprogramming efficiency (1.89% of starting cells was observed with the mRNA based method which was almost 20 fold higher than that observed with the retrovirus (0.2% and episomal plasmid (0.10% methods. Standard characterisation tests did not reveal any differences in an array of pluripotency markers between the iPS lines derived using the various methods. However, when the same methods were used to reprogram three different primary fibroblasts lines, two derived from patients with rapid onset parkinsonism dystonia and one from an elderly healthy volunteer, we consistently observed higher reprogramming efficiencies with the episomal plasmid method, which was 4 fold higher when compared to the retroviral method and over 50 fold higher than the mRNA method. Additionally, with the plasmid reprogramming protocol, recombinant vitronectin and synthemax® could be used together with commercially available, fully defined, xeno-free essential 8 medium without significantly impacting the reprogramming efficiency. To demonstrate the robustness of this protocol, we reprogrammed a further 2 primary patient cell lines, one with retinosa pigmentosa and the other with Parkinsons disease. We believe that we have optimised a simple and reproducible method which could be used as a starting point for developing GMP protocols, a prerequisite for generating clinically relevant patient specific iPS cells.

  7. Neonatal Desensitization Supports Long-Term Survival and Functional Integration of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in Rat Joint Cartilage Without Immunosuppression

    Science.gov (United States)

    Zhang, Shufang; Jiang, Yang Zi; Zhang, Wei; Chen, Longkun; Tong, Tong; Liu, Wanlu; Mu, Qin; Liu, Hua; Ji, Junfeng; Ouyang, Hong Wei

    2013-01-01

    Immunological response hampers the investigation of human embryonic stem cells (hESCs) or their derivates for tissue regeneration in vivo. Immunosuppression is often used after surgery, but exhibits side effects of significant weight loss and allows only short-term observation. The purpose of this study was to investigate whether neonatal desensitization supports relative long-term survival of hESC-derived mesenchymal stem cells (hESC-MSCs) and promotes cartilage regeneration. hESC-MSCs were injected on the day of birth in rats. Six weeks after neonatal injection, a full-thickness cylindrical cartilage defect was created and transplanted with a hESC-MSC-seeded collagen bilayer scaffold (group d+s+c) or a collagen bilayer scaffold (group d+s). Rats without neonatal injection were transplanted with the hESC-MSC-seeded collagen bilayer scaffold to serve as controls (group s+c). Cartilage regeneration was evaluated by histological analysis, immunohistochemical staining, and biomechanical test. The role of hESC-MSCs in cartilage regeneration was analyzed by CD4 immunostaining, cell death detection, and visualization of human cells in regenerated tissues. hESC-MSCs expressed CD105, CD73, CD90, CD29, and CD44, but not CD45 and CD34, and possessed trilineage differentiation potential. Group d+s+c exhibited greater International Cartilage Repair Society (ICRS) scores than group d+s or group s+c. Abundant collagen type II and improved mechanical properties were detected in group d+s+c. There were less CD4+ inflammatory cell infiltration and cell death at week 1, and hESC-MSCs were found to survive as long as 8 weeks after transplantation in group d+s+c. Our study suggests that neonatal desensitization before transplantation may be an efficient way to develop a powerful tool for preclinical study of human cell-based therapies in animal models. PMID:22788986

  8. An Empirical Model for Energy Storage Systems

    Energy Technology Data Exchange (ETDEWEB)

    Rosewater, David Martin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Scott, Paul [TransPower, Poway, CA (United States)

    2016-03-17

    Improved models of energy storage systems are needed to enable the electric grid’s adaptation to increasing penetration of renewables. This paper develops a generic empirical model of energy storage system performance agnostic of type, chemistry, design or scale. Parameters for this model are calculated using test procedures adapted from the US DOE Protocol for Uniformly Measuring and Expressing the Performance of Energy Storage. We then assess the accuracy of this model for predicting the performance of the TransPower GridSaver – a 1 MW rated lithium-ion battery system that underwent laboratory experimentation and analysis. The developed model predicts a range of energy storage system performance based on the uncertainty of estimated model parameters. Finally, this model can be used to better understand the integration and coordination of energy storage on the electric grid.

  9. Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations

    DEFF Research Database (Denmark)

    Momcilovic, Olga; Sivapatham, Renuka; Oron, Tal Ronnen

    2016-01-01

    We report generation of induced pluripotent stem cell (iPSC) lines from ten Parkinson's disease (PD) patients carrying SNCA, PARK2, LRRK2, and GBA mutations, and one age-matched control. After validation of pluripotency, long-term genome stability, and integration-free reprogramming, eight...... not be sufficient to determine the cause or mechanism of the disease, and highlights the need to use more focused strategies for large-scale data analysis........ We further examined gene expression in a stress model (MPTP-induced dopaminergic neuronal death) using two clones from the SNCA triplication line, and detected changes in genes associated with mitophagy. Our data suggested that even a well-characterized line of a monogenic disease may...

  10. Generation of integration-free induced pluripotent stem cell lines derived from two patients with X-linked Alport syndrome (XLAS).

    Science.gov (United States)

    Kuebler, Bernd; Aran, Begoña; Miquel-Serra, Laia; Muñoz, Yolanda; Ars, Elisabet; Bullich, Gemma; Furlano, Monica; Torra, Roser; Marti, Merce; Veiga, Anna; Raya, Angel

    2017-12-01

    Skin biopsies were obtained from two male patients with X-linked Alport syndrome (XLAS) with hemizygous COL4A5 mutations in exon 41 or exon 46. Dermal fibroblasts were extracted and reprogrammed by nucleofection with episomal plasmids carrying OCT3/4, SOX2, KLF4 LIN28, L-MYC and p53 shRNA. The generated induced Pluripotent Stem Cell (iPSC) lines AS-FiPS2-Ep6F-28 and AS-FiPS3-Ep6F-9 were free of genomically integrated reprogramming genes, had the specific mutations, a stable karyotype, expressed pluripotency markers and generated embryoid bodies which were differentiated towards the three germ layers in vitro. These iPSC lines offer a useful resource to study Alport syndrome pathomechanisms and drug testing. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  11. Investigating complex patterns of blocked intestinal artery blood pressure signals by empirical mode decomposition and linguistic analysis

    International Nuclear Information System (INIS)

    Yeh, J-R; Lin, T-Y; Shieh, J-S; Chen, Y; Huang, N E; Wu, Z; Peng, C-K

    2008-01-01

    In this investigation, surgical operations of blocked intestinal artery have been conducted on pigs to simulate the condition of acute mesenteric arterial occlusion. The empirical mode decomposition method and the algorithm of linguistic analysis were applied to verify the blood pressure signals in simulated situation. We assumed that there was some information hidden in the high-frequency part of the blood pressure signal when an intestinal artery is blocked. The empirical mode decomposition method (EMD) has been applied to decompose the intrinsic mode functions (IMF) from a complex time series. But, the end effects and phenomenon of intermittence damage the consistence of each IMF. Thus, we proposed the complementary ensemble empirical mode decomposition method (CEEMD) to solve the problems of end effects and the phenomenon of intermittence. The main wave of blood pressure signals can be reconstructed by the main components, identified by Monte Carlo verification, and removed from the original signal to derive a riding wave. Furthermore, the concept of linguistic analysis was applied to design the blocking index to verify the pattern of riding wave of blood pressure using the measurements of dissimilarity. Blocking index works well to identify the situation in which the sampled time series of blood pressure signal was recorded. Here, these two totally different algorithms are successfully integrated and the existence of the existence of information hidden in high-frequency part of blood pressure signal has been proven

  12. Investigating complex patterns of blocked intestinal artery blood pressure signals by empirical mode decomposition and linguistic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Yeh, J-R; Lin, T-Y; Shieh, J-S [Department of Mechanical Engineering, Yuan Ze University, 135 Far-East Road, Chung-Li, Taoyuan, Taiwan (China); Chen, Y [Far Eastern Memorial Hospital, Taiwan (China); Huang, N E [Research Center for Adaptive Data Analysis, National Central University, Taiwan (China); Wu, Z [Center for Ocean-Land-Atmosphere Studies (United States); Peng, C-K [Beth Israel Deaconess Medical Center, Harvard Medical School (United States)], E-mail: s939205@ mail.yzu.edu.tw

    2008-02-15

    In this investigation, surgical operations of blocked intestinal artery have been conducted on pigs to simulate the condition of acute mesenteric arterial occlusion. The empirical mode decomposition method and the algorithm of linguistic analysis were applied to verify the blood pressure signals in simulated situation. We assumed that there was some information hidden in the high-frequency part of the blood pressure signal when an intestinal artery is blocked. The empirical mode decomposition method (EMD) has been applied to decompose the intrinsic mode functions (IMF) from a complex time series. But, the end effects and phenomenon of intermittence damage the consistence of each IMF. Thus, we proposed the complementary ensemble empirical mode decomposition method (CEEMD) to solve the problems of end effects and the phenomenon of intermittence. The main wave of blood pressure signals can be reconstructed by the main components, identified by Monte Carlo verification, and removed from the original signal to derive a riding wave. Furthermore, the concept of linguistic analysis was applied to design the blocking index to verify the pattern of riding wave of blood pressure using the measurements of dissimilarity. Blocking index works well to identify the situation in which the sampled time series of blood pressure signal was recorded. Here, these two totally different algorithms are successfully integrated and the existence of the existence of information hidden in high-frequency part of blood pressure signal has been proven.

  13. Gene-based SSR markers for common bean (Phaseolus vulgaris L.) derived from root and leaf tissue ESTs: an integration of the BMc series.

    Science.gov (United States)

    Blair, Matthew W; Hurtado, Natalia; Chavarro, Carolina M; Muñoz-Torres, Monica C; Giraldo, Martha C; Pedraza, Fabio; Tomkins, Jeff; Wing, Rod

    2011-03-22

    Sequencing of cDNA libraries for the development of expressed sequence tags (ESTs) as well as for the discovery of simple sequence repeats (SSRs) has been a common method of developing microsatellites or SSR-based markers. In this research, our objective was to further sequence and develop common bean microsatellites from leaf and root cDNA libraries derived from the Andean gene pool accession G19833 and the Mesoamerican gene pool accession DOR364, mapping parents of a commonly used reference map. The root libraries were made from high and low phosphorus treated plants. A total of 3,123 EST sequences from leaf and root cDNA libraries were screened and used for direct simple sequence repeat discovery. From these EST sequences we found 184 microsatellites; the majority containing tri-nucleotide motifs, many of which were GC rich (ACC, AGC and AGG in particular). Di-nucleotide motif microsatellites were about half as common as the tri-nucleotide motif microsatellites but most of these were AGn microsatellites with a moderate number of ATn microsatellites in root ESTs followed by few ACn and no GCn microsatellites. Out of the 184 new SSR loci, 120 new microsatellite markers were developed in the BMc (Bean Microsatellites from cDNAs) series and these were evaluated for their capacity to distinguish bean diversity in a germplasm panel of 18 genotypes. We developed a database with images of the microsatellites and their polymorphism information content (PIC), which averaged 0.310 for polymorphic markers. The present study produced information about microsatellite frequency in root and leaf tissues of two important genotypes for common bean genomics: namely G19833, the Andean genotype selected for whole genome shotgun sequencing from race Peru, and DOR364 a race Mesoamerica subgroup 2 genotype that is a small-red seeded, released variety in Central America. Both race Peru and Mesoamerica subgroup 2 (small red beans) have been understudied in comparison to race Nueva

  14. Global statistics of liquid water content and effective number concentration of water clouds over ocean derived from combined CALIPSO and MODIS measurements

    OpenAIRE

    Hu, Y.; Vaughan, M.; McClain, C.; Behrenfeld, M.; Maring, H.; Anderson, D.; Sun-Mack, S.; Flittner, D.; Huang, J.; Wielicki, B.; Minnis, P.; Weimer, C.; Trepte, C.; Kuehn, R.

    2007-01-01

    International audience; This study presents an empirical relation that links the volume extinction coefficients of water clouds, the layer integrated depolarization ratios measured by lidar, and the effective radii of water clouds derived from collocated passive sensor observations. Based on Monte Carlo simulations of CALIPSO lidar observations, this method combines the cloud effective radius reported by MODIS with the lidar depolarization ratios measured by CALIPSO to estimate both the liqui...

  15. Predicting acid dew point with a semi-empirical model

    International Nuclear Information System (INIS)

    Xiang, Baixiang; Tang, Bin; Wu, Yuxin; Yang, Hairui; Zhang, Man; Lu, Junfu

    2016-01-01

    Highlights: • The previous semi-empirical models are systematically studied. • An improved thermodynamic correlation is derived. • A semi-empirical prediction model is proposed. • The proposed semi-empirical model is validated. - Abstract: Decreasing the temperature of exhaust flue gas in boilers is one of the most effective ways to further improve the thermal efficiency, electrostatic precipitator efficiency and to decrease the water consumption of desulfurization tower, while, when this temperature is below the acid dew point, the fouling and corrosion will occur on the heating surfaces in the second pass of boilers. So, the knowledge on accurately predicting the acid dew point is essential. By investigating the previous models on acid dew point prediction, an improved thermodynamic correlation formula between the acid dew point and its influencing factors is derived first. And then, a semi-empirical prediction model is proposed, which is validated with the data both in field test and experiment, and comparing with the previous models.

  16. Guidelines for using empirical studies in software engineering education

    Directory of Open Access Journals (Sweden)

    Fabian Fagerholm

    2017-09-01

    Full Text Available Software engineering education is under constant pressure to provide students with industry-relevant knowledge and skills. Educators must address issues beyond exercises and theories that can be directly rehearsed in small settings. Industry training has similar requirements of relevance as companies seek to keep their workforce up to date with technological advances. Real-life software development often deals with large, software-intensive systems and is influenced by the complex effects of teamwork and distributed software development, which are hard to demonstrate in an educational environment. A way to experience such effects and to increase the relevance of software engineering education is to apply empirical studies in teaching. In this paper, we show how different types of empirical studies can be used for educational purposes in software engineering. We give examples illustrating how to utilize empirical studies, discuss challenges, and derive an initial guideline that supports teachers to include empirical studies in software engineering courses. Furthermore, we give examples that show how empirical studies contribute to high-quality learning outcomes, to student motivation, and to the awareness of the advantages of applying software engineering principles. Having awareness, experience, and understanding of the actions required, students are more likely to apply such principles under real-life constraints in their working life.

  17. Empirically characteristic analysis of chaotic PID controlling particle swarm optimization

    Science.gov (United States)

    Yan, Danping; Lu, Yongzhong; Zhou, Min; Chen, Shiping; Levy, David

    2017-01-01

    Since chaos systems generally have the intrinsic properties of sensitivity to initial conditions, topological mixing and density of periodic orbits, they may tactfully use the chaotic ergodic orbits to achieve the global optimum or their better approximation to given cost functions with high probability. During the past decade, they have increasingly received much attention from academic community and industry society throughout the world. To improve the performance of particle swarm optimization (PSO), we herein propose a chaotic proportional integral derivative (PID) controlling PSO algorithm by the hybridization of chaotic logistic dynamics and hierarchical inertia weight. The hierarchical inertia weight coefficients are determined in accordance with the present fitness values of the local best positions so as to adaptively expand the particles’ search space. Moreover, the chaotic logistic map is not only used in the substitution of the two random parameters affecting the convergence behavior, but also used in the chaotic local search for the global best position so as to easily avoid the particles’ premature behaviors via the whole search space. Thereafter, the convergent analysis of chaotic PID controlling PSO is under deep investigation. Empirical simulation results demonstrate that compared with other several chaotic PSO algorithms like chaotic PSO with the logistic map, chaotic PSO with the tent map and chaotic catfish PSO with the logistic map, chaotic PID controlling PSO exhibits much better search efficiency and quality when solving the optimization problems. Additionally, the parameter estimation of a nonlinear dynamic system also further clarifies its superiority to chaotic catfish PSO, genetic algorithm (GA) and PSO. PMID:28472050

  18. Empirically characteristic analysis of chaotic PID controlling particle swarm optimization.

    Directory of Open Access Journals (Sweden)

    Danping Yan

    Full Text Available Since chaos systems generally have the intrinsic properties of sensitivity to initial conditions, topological mixing and density of periodic orbits, they may tactfully use the chaotic ergodic orbits to achieve the global optimum or their better approximation to given cost functions with high probability. During the past decade, they have increasingly received much attention from academic community and industry society throughout the world. To improve the performance of particle swarm optimization (PSO, we herein propose a chaotic proportional integral derivative (PID controlling PSO algorithm by the hybridization of chaotic logistic dynamics and hierarchical inertia weight. The hierarchical inertia weight coefficients are determined in accordance with the present fitness values of the local best positions so as to adaptively expand the particles' search space. Moreover, the chaotic logistic map is not only used in the substitution of the two random parameters affecting the convergence behavior, but also used in the chaotic local search for the global best position so as to easily avoid the particles' premature behaviors via the whole search space. Thereafter, the convergent analysis of chaotic PID controlling PSO is under deep investigation. Empirical simulation results demonstrate that compared with other several chaotic PSO algorithms like chaotic PSO with the logistic map, chaotic PSO with the tent map and chaotic catfish PSO with the logistic map, chaotic PID controlling PSO exhibits much better search efficiency and quality when solving the optimization problems. Additionally, the parameter estimation of a nonlinear dynamic system also further clarifies its superiority to chaotic catfish PSO, genetic algorithm (GA and PSO.

  19. Health monitoring of pipeline girth weld using empirical mode decomposition

    Science.gov (United States)

    Rezaei, Davood; Taheri, Farid

    2010-05-01

    In the present paper the Hilbert-Huang transform (HHT), as a time-series analysis technique, has been combined with a local diagnostic approach in an effort to identify flaws in pipeline girth welds. This method is based on monitoring the free vibration signals of the pipe at its healthy and flawed states, and processing the signals through the HHT and its associated signal decomposition technique, known as empirical mode decomposition (EMD). The EMD method decomposes the vibration signals into a collection of intrinsic mode functions (IMFs). The deviations in structural integrity, measured from a healthy-state baseline, are subsequently evaluated by two damage sensitive parameters. The first is a damage index, referred to as the EM-EDI, which is established based on an energy comparison of the first or second IMF of the vibration signals, before and after occurrence of damage. The second parameter is the evaluation of the lag in instantaneous phase, a quantity derived from the HHT. In the developed methodologies, the pipe's free vibration is monitored by piezoceramic sensors and a laser Doppler vibrometer. The effectiveness of the proposed techniques is demonstrated through a set of numerical and experimental studies on a steel pipe with a mid-span girth weld, for both pressurized and nonpressurized conditions. To simulate a crack, a narrow notch is cut on one side of the girth weld. Several damage scenarios, including notches of different depths and at various locations on the pipe, are investigated. Results from both numerical and experimental studies reveal that in all damage cases the sensor located at the notch vicinity could successfully detect the notch and qualitatively predict its severity. The effect of internal pressure on the damage identification method is also monitored. Overall, the results are encouraging and promise the effectiveness of the proposed approaches as inexpensive systems for structural health monitoring purposes.

  20. Essays in empirical industrial organization

    OpenAIRE

    Aguiar de Luque, Luis

    2013-01-01

    My PhD thesis consists of three chapters in Empirical Industrial Organization. The first two chapters focus on the relationship between firrm performance and specific public policies. In particular, we analyze the cases of cooperative research and development (R&D) in the European Union and the regulation of public transports in France. The third chapter focuses on copyright protection in the digital era and analyzes the relationship between legal and illegal consumption of di...

  1. Empirical research on Waldorf education

    OpenAIRE

    Randoll, Dirk; Peters, Jürgen

    2015-01-01

    Waldorf education began in 1919 with the first Waldorf School in Stuttgart and nowadays is widespread in many countries all over the world. Empirical research, however, has been rare until the early nineties and Waldorf education has not been discussed within educational science so far. This has changed during the last decades. This article reviews the results of surveys during the last 20 years and is mainly focused on German Waldorf Schools, because most investigations have been done in thi...

  2. Empirical distribution function under heteroscedasticity

    Czech Academy of Sciences Publication Activity Database

    Víšek, Jan Ámos

    2011-01-01

    Roč. 45, č. 5 (2011), s. 497-508 ISSN 0233-1888 Grant - others:GA UK(CZ) GA402/09/0557 Institutional research plan: CEZ:AV0Z10750506 Keywords : Robustness * Convergence * Empirical distribution * Heteroscedasticity Subject RIV: BB - Applied Statistics , Operational Research Impact factor: 0.724, year: 2011 http://library.utia.cas.cz/separaty/2011/SI/visek-0365534.pdf

  3. Expert opinion vs. empirical evidence

    OpenAIRE

    Herman, Rod A; Raybould, Alan

    2014-01-01

    Expert opinion is often sought by government regulatory agencies when there is insufficient empirical evidence to judge the safety implications of a course of action. However, it can be reckless to continue following expert opinion when a preponderance of evidence is amassed that conflicts with this opinion. Factual evidence should always trump opinion in prioritizing the information that is used to guide regulatory policy. Evidence-based medicine has seen a dramatic upturn in recent years sp...

  4. Empirical isotropic chemical shift surfaces

    International Nuclear Information System (INIS)

    Czinki, Eszter; Csaszar, Attila G.

    2007-01-01

    A list of proteins is given for which spatial structures, with a resolution better than 2.5 A, are known from entries in the Protein Data Bank (PDB) and isotropic chemical shift (ICS) values are known from the RefDB database related to the Biological Magnetic Resonance Bank (BMRB) database. The structures chosen provide, with unknown uncertainties, dihedral angles φ and ψ characterizing the backbone structure of the residues. The joint use of experimental ICSs of the same residues within the proteins, again with mostly unknown uncertainties, and ab initio ICS(φ,ψ) surfaces obtained for the model peptides For-(l-Ala) n -NH 2 , with n = 1, 3, and 5, resulted in so-called empirical ICS(φ,ψ) surfaces for all major nuclei of the 20 naturally occurring α-amino acids. Out of the many empirical surfaces determined, it is the 13C α ICS(φ,ψ) surface which seems to be most promising for identifying major secondary structure types, α-helix, β-strand, left-handed helix (α D ), and polyproline-II. Detailed tests suggest that Ala is a good model for many naturally occurring α-amino acids. Two-dimensional empirical 13C α - 1 H α ICS(φ,ψ) correlation plots, obtained so far only from computations on small peptide models, suggest the utility of the experimental information contained therein and thus they should provide useful constraints for structure determinations of proteins

  5. Two concepts of empirical ethics.

    Science.gov (United States)

    Parker, Malcolm

    2009-05-01

    The turn to empirical ethics answers two calls. The first is for a richer account of morality than that afforded by bioethical principlism, which is cast as excessively abstract and thin on the facts. The second is for the facts in question to be those of human experience and not some other, unworldly realm. Empirical ethics therefore promises a richer naturalistic ethics, but in fulfilling the second call it often fails to heed the metaethical requirements related to the first. Empirical ethics risks losing the normative edge which necessarily characterizes the ethical, by failing to account for the nature and the logic of moral norms. I sketch a naturalistic theory, teleological expressivism (TE), which negotiates the naturalistic fallacy by providing a more satisfactory means of taking into account facts and research data with ethical implications. The examples of informed consent and the euthanasia debate are used to illustrate the superiority of this approach, and the problems consequent on including the facts in the wrong kind of way.

  6. The impact of regional environmental regulations on empirical vessel speeds

    OpenAIRE

    Ådland, Roar Os; Fonnes, Gro; Jia, Haiying; Daae Lampe, Ove; Strandenes, Siri Pettersen

    2017-01-01

    Economic theory suggests that the use of more expensive low-sulphur fuel within an Emission Control Area (ECA) should result in lower vessel speeds. The objective of this paper is to investigate empirically, for the first time, whether the introduction of an ECA affects vessel speeds. We utilize a dataset of observed vessel speeds derived from the Automated Information System (AIS) for nearly 7000 ECA boundary crossings over a three-year period. Our results suggest that introducing stricter s...

  7. A Socio-Cultural Model Based on Empirical Data of Cultural and Social Relationship

    DEFF Research Database (Denmark)

    Lipi, Afia Akhter; Nakano, Yukiko; Rehm, Matthias

    2010-01-01

    The goal of this paper is to integrate culture and social relationship as a computational term in an embodied conversational agent system by employing empirical and theoretical approach. We propose a parameter-based model that predicts nonverbal expressions appropriate for specific cultures...... in different social relationship. So, first, we introduce the theories of social and cultural characteristics. Then, we did corpus analysis of human interaction of two cultures in two different social situations and extracted empirical data and finally, by integrating socio-cultural characteristics...... with empirical data, we establish a parameterized network model that generates culture specific non-verbal expressions in different social relationships....

  8. A Comprehensive Theory of Integration.

    Science.gov (United States)

    Singer, Sara J; Kerrissey, Michaela; Friedberg, Mark; Phillips, Russell

    2018-03-01

    Efforts to transform health care delivery to improve care have increasingly focused on care integration. However, variation in how integration is defined has complicated efforts to design, synthesize, and compare studies of integration in health care. Evaluations of integration initiatives would be enhanced by describing them according to clear definitions of integration and specifying which empirical relationships they seek to test-whether among types of integration or between integration and outcomes of care. Drawing on previous work, we present a comprehensive theoretical model of relationships between types of integration and propose how to measure them.

  9. Empirical Phenomenology: A Qualitative Research Approach (The ...

    African Journals Online (AJOL)

    Empirical Phenomenology: A Qualitative Research Approach (The Cologne Seminars) ... and practical application of empirical phenomenology in social research. ... and considers its implications for qualitative methods such as interviewing ...

  10. Derivative chameleons

    International Nuclear Information System (INIS)

    Noller, Johannes

    2012-01-01

    We consider generalized chameleon models where the conformal coupling between matter and gravitational geometries is not only a function of the chameleon field φ, but also of its derivatives via higher order co-ordinate invariants (such as ∂ μ φ∂ μ φ,□φ,...). Specifically we consider the first such non-trivial conformal factor A(φ,∂ μ φ∂ μ φ). The associated phenomenology is investigated and we show that such theories have a new generic mass-altering mechanism, potentially assisting the generation of a sufficiently large chameleon mass in dense environments. The most general effective potential is derived for such derivative chameleon setups and explicit examples are given. Interestingly this points us to the existence of a purely derivative chameleon protected by a shift symmetry for φ → φ+c. We also discuss potential ghost-like instabilities associated with mass-lifting mechanisms and find another, mass-lowering and instability-free, branch of solutions. This suggests that, barring fine-tuning, stable derivative models are in fact typically anti-chameleons that suppress the field's mass in dense environments. Furthermore we investigate modifications to the thin-shell regime and prove a no-go theorem for chameleon effects in non-conformal geometries of the disformal type

  11. Derivative chameleons

    Energy Technology Data Exchange (ETDEWEB)

    Noller, Johannes, E-mail: johannes.noller08@imperial.ac.uk [Theoretical Physics, Blackett Laboratory, Imperial College London, Prince Consort Road, London, SW7 2BZ (United Kingdom)

    2012-07-01

    We consider generalized chameleon models where the conformal coupling between matter and gravitational geometries is not only a function of the chameleon field φ, but also of its derivatives via higher order co-ordinate invariants (such as ∂{sub μ}φ∂{sup μ}φ,□φ,...). Specifically we consider the first such non-trivial conformal factor A(φ,∂{sub μ}φ∂{sup μ}φ). The associated phenomenology is investigated and we show that such theories have a new generic mass-altering mechanism, potentially assisting the generation of a sufficiently large chameleon mass in dense environments. The most general effective potential is derived for such derivative chameleon setups and explicit examples are given. Interestingly this points us to the existence of a purely derivative chameleon protected by a shift symmetry for φ → φ+c. We also discuss potential ghost-like instabilities associated with mass-lifting mechanisms and find another, mass-lowering and instability-free, branch of solutions. This suggests that, barring fine-tuning, stable derivative models are in fact typically anti-chameleons that suppress the field's mass in dense environments. Furthermore we investigate modifications to the thin-shell regime and prove a no-go theorem for chameleon effects in non-conformal geometries of the disformal type.

  12. Empirical yield tables for Michigan.

    Science.gov (United States)

    Jerold T. Hahn; Joan M. Stelman

    1984-01-01

    Describes the tables derived from the 1980 Forest Survey of Michigan and presents ways the tables can be used. These tables are broken down according to Michigan's four Forest Survey Units, 14 forest types, and 5 site-index classes.

  13. Empirical yield tables for Wisconsin.

    Science.gov (United States)

    Jerold T. Hahn; Joan M. Stelman

    1989-01-01

    Describes the tables derived from the 1983 Forest Survey of Wisconsin and presents ways the tables can be used. These tables are broken down according to Wisconsin`s five Forest Survey Units and 14 forest types.

  14. Electricity derivatives

    CERN Document Server

    Aïd, René

    2015-01-01

    Offering a concise but complete survey of the common features of the microstructure of electricity markets, this book describes the state of the art in the different proposed electricity price models for pricing derivatives and in the numerical methods used to price and hedge the most prominent derivatives in electricity markets, namely power plants and swings. The mathematical content of the book has intentionally been made light in order to concentrate on the main subject matter, avoiding fastidious computations. Wherever possible, the models are illustrated by diagrams. The book should allow prospective researchers in the field of electricity derivatives to focus on the actual difficulties associated with the subject. It should also offer a brief but exhaustive overview of the latest techniques used by financial engineers in energy utilities and energy trading desks.

  15. Science and the British Empire.

    Science.gov (United States)

    Harrison, Mark

    2005-03-01

    The last few decades have witnessed a flowering of interest in the history of science in the British Empire. This essay aims to provide an overview of some of the most important work in this area, identifying interpretative shifts and emerging themes. In so doing, it raises some questions about the analytical framework in which colonial science has traditionally been viewed, highlighting interactions with indigenous scientific traditions and the use of network-based models to understand scientific relations within and beyond colonial contexts.

  16. Empirical logic and tensor products

    International Nuclear Information System (INIS)

    Foulis, D.J.; Randall, C.H.

    1981-01-01

    In our work we are developing a formalism called empirical logic to support a generalization of conventional statistics; the resulting generalization is called operational statistics. We are not attempting to develop or advocate any particular physical theory; rather we are formulating a precision 'language' in which such theories can be expressed, compared, evaluated, and related to laboratory experiments. We believe that only in such a language can the connections between real physical procedures (operations) and physical theories be made explicit and perspicuous. (orig./HSI)

  17. Multiscale empirical modeling of the geomagnetic field: From storms to substorms

    Science.gov (United States)

    Stephens, G. K.; Sitnov, M. I.; Korth, H.; Gkioulidou, M.; Ukhorskiy, A. Y.; Merkin, V. G.

    2017-12-01

    An advanced version of the TS07D empirical geomagnetic field model, herein called SST17, is used to model the global picture of the geomagnetic field and its characteristic variations on both storm and substorm scales. The new SST17 model uses two regular expansions describing the equatorial currents with each having distinctly different scales, one corresponding to a thick and one to a thin current sheet relative to the thermal ion gyroradius. These expansions have an arbitrary distribution of currents in the equatorial plane that is constrained only by magnetometer data. This multi-scale description allows one to reproduce the current sheet thinning during the growth phase. Additionaly, the model uses a flexible description of field-aligned currents that reproduces their spiral structure at low altitudes and provides a continuous transition from region 1 to region 2 current systems. The empirical picture of substorms is obtained by combining magnetometer data from Geotail, THEMIS, Van Allen Probes, Cluster II, Polar, IMP-8, GOES 8, 9, 10 and 12 and then binning this data based on similar values of the auroral index AL, its time derivative and the integral of the solar wind electric field parameter (from ACE, Wind, and IMP-8) in time over substorm scales. The performance of the model is demonstrated for several events, including the 3 July 2012 substorm, which had multi-probe coverage and a series of substorms during the March 2008 storm. It is shown that the AL binning helps reproduce dipolarization signatures in the northward magnetic field Bz, while the solar wind electric field integral allows one to capture the current sheet thinning during the growth phase. The model allows one to trace the substorm dipolarization from the tail to the inner magnetosphere where the dipolarization of strongly stretched tail field lines causes a redistribution of the tail current resulting in an enhancement of the partial ring current in the premidnight sector.

  18. Essays on pricing electricity and electricity derivatives in deregulated markets

    Science.gov (United States)

    Popova, Julia

    2008-10-01

    This dissertation is composed of four essays on the behavior of wholesale electricity prices and their derivatives. The first essay provides an empirical model that takes into account the spatial features of a transmission network on the electricity market. The spatial structure of the transmission grid plays a key role in determining electricity prices, but it has not been incorporated into previous empirical models. The econometric model in this essay incorporates a simple representation of the transmission system into a spatial panel data model of electricity prices, and also accounts for the effect of dynamic transmission system constraints on electricity market integration. Empirical results using PJM data confirm the existence of spatial patterns in electricity prices and show that spatial correlation diminishes as transmission lines become more congested. The second essay develops and empirically tests a model of the influence of natural gas storage inventories on the electricity forward premium. I link a model of the effect of gas storage constraints on the higher moments of the distribution of electricity prices to a model of the effect of those moments on the forward premium. Empirical results using PJM data support the model's predictions that gas storage inventories sharply reduce the electricity forward premium when demand for electricity is high and space-heating demand for gas is low. The third essay examines the efficiency of PJM electricity markets. A market is efficient if prices reflect all relevant information, so that prices follow a random walk. The hypothesis of random walk is examined using empirical tests, including the Portmanteau, Augmented Dickey-Fuller, KPSS, and multiple variance ratio tests. The results are mixed though evidence of some level of market efficiency is found. The last essay investigates the possibility that previous researchers have drawn spurious conclusions based on classical unit root tests incorrectly applied to

  19. An integral heuristic

    International Nuclear Information System (INIS)

    Kauffman, L.H.

    1990-01-01

    This paper gives a heuristic derivation of the skein relation for the Homfly polynomial in an integral formalism. The derivation is formally correct but highly simplified. In the light of Witten's proposal for invariants of links via functional integrals, it is useful to have a formal pattern to compare with the complexities of the full approach. The formalism is a heuristic. However, it is closely related to the actual structure of the Witten functional integral

  20. Empirical reality, empirical causality, and the measurement problem

    International Nuclear Information System (INIS)

    d'Espagnat, B.

    1987-01-01

    Does physics describe anything that can meaningfully be called independent reality, or is it merely operational? Most physicists implicitly favor an intermediate standpoint, which takes quantum physics into account, but which nevertheless strongly holds fast to quite strictly realistic ideas about apparently obvious facts concerning the macro-objects. Part 1 of this article, which is a survey of recent measurement theories, shows that, when made explicit, the standpoint in question cannot be upheld. Part 2 brings forward a proposal for making minimal changes to this standpoint in such a way as to remove such objections. The empirical reality thus constructed is a notion that, to some extent, does ultimately refer to the human means of apprehension and of data processing. It nevertheless cannot be said that it reduces to a mere name just labelling a set of recipes that never fail. It is shown that their usual notion of macroscopic causality must be endowed with similar features

  1. Integration of Chandrasekhar's integral equation

    International Nuclear Information System (INIS)

    Tanaka, Tasuku

    2003-01-01

    We solve Chandrasekhar's integration equation for radiative transfer in the plane-parallel atmosphere by iterative integration. The primary thrust in radiative transfer has been to solve the forward problem, i.e., to evaluate the radiance, given the optical thickness and the scattering phase function. In the area of satellite remote sensing, our problem is the inverse problem: to retrieve the surface reflectance and the optical thickness of the atmosphere from the radiance measured by satellites. In order to retrieve the optical thickness and the surface reflectance from the radiance at the top-of-the atmosphere (TOA), we should express the radiance at TOA 'explicitly' in the optical thickness and the surface reflectance. Chandrasekhar formalized radiative transfer in the plane-parallel atmosphere in a simultaneous integral equation, and he obtained the second approximation. Since then no higher approximation has been reported. In this paper, we obtain the third approximation of the scattering function. We integrate functions derived from the second approximation in the integral interval from 1 to ∞ of the inverse of the cos of zenith angles. We can obtain the indefinite integral rather easily in the form of a series expansion. However, the integrals at the upper limit, ∞, are not yet known to us. We can assess the converged values of those series expansions at ∞ through calculus. For integration, we choose coupling pairs to avoid unnecessary terms in the outcome of integral and discover that the simultaneous integral equation can be deduced to the mere integral equation. Through algebraic calculation, we obtain the third approximation as a polynomial of the third degree in the atmospheric optical thickness

  2. “Nobody tosses a dwarf!” The relation between the empirical and normative reexamined

    Science.gov (United States)

    Leget, C.; Borry, P.; De Vries, R.

    2009-01-01

    This article discusses the relation between empirical and normative approaches in bioethics. The issue of dwarf tossing, while admittedly unusual, is chosen as point of departure because it challenges the reader to look upon several central bioethical themes – including human dignity, autonomy, and the protection of vulnerable people – with fresh eyes. After an overview of current approaches to the integration of empirical and normative ethics, we consider five ways that the empirical and normative can be brought together to speak to the problem of dwarf tossing: prescriptive applied ethics, theorist ethics, critical applied ethics, particularist ethics and integrated empirical ethics. We defend a position of critical applied ethics that allows for a two-way relation between empirical and normative theories. The approach we endorse acknowledges that a social practice can and should be judged by both the gathering of empirical data and by the normative ethics. Critical applied ethics uses a five stage process that includes: (a) determination of the problem, (b) description of the problem, (c) empirical study of effects and alternatives, (d) normative weighing and (e) evaluation of the effects of a decision. In each stage, we explore the perspective from both the empirical (sociological) and the normative ethical poles that, in our view, should operate as two independent focuses of the ellipse that is called bioethics. We conclude by applying our five stage critical applied ethics to the example of dwarf tossing. PMID:19338523

  3. Geostationary Satellite Observation of Precipitable Water Vapor Using an Empirical Orthogonal Function (EOF based Reconstruction Technique over Eastern China

    Directory of Open Access Journals (Sweden)

    Man Sing Wong

    2015-05-01

    Full Text Available Water vapor, as one of the most important greenhouse gases, is crucial for both climate and atmospheric studies. Considering the high spatial and temporal variations of water vapor, a timely and accurate retrieval of precipitable water vapor (PWV is urgently needed, but has long been constrained by data availability. Our study derived the vertically integrated precipitable water vapor over eastern China using Multi-functional Transport Satellite (MTSAT data, which is in geostationary orbit with high temporal resolution. The missing pixels caused by cloud contamination were reconstructed using an Empirical Orthogonal Function (EOF decomposition method over both spatial and temporal dimensions. GPS meteorology data were used to validate the retrieval and the reconstructed results. The diurnal variation of PWV over eastern China was analyzed using harmonic analysis, which indicates that the reconstructed PWV data can depict the diurnal cycle of PWV caused by evapotranspiration and local thermal circulation.

  4. Transformation of an empirical distribution to normal distribution by the use of Johnson system of translation and symmetrical quantile method

    OpenAIRE

    Ludvík Friebel; Jana Friebelová

    2006-01-01

    This article deals with approximation of empirical distribution to standard normal distribution using Johnson transformation. This transformation enables us to approximate wide spectrum of continuous distributions with a normal distribution. The estimation of parameters of transformation formulas is based on percentiles of empirical distribution. There are derived theoretical probability distribution functions of random variable obtained on the base of backward transformation standard normal ...

  5. Proposed empirical gas geothermometer using multidimensional approach

    Energy Technology Data Exchange (ETDEWEB)

    Supranto; Sudjatmiko; Toha, Budianto; Wintolo, Djoko; Alhamid, Idrus

    1996-01-24

    Several formulas of surface gas geothermometer have been developed to utilize in geothermal exploration, i.e. by D'Amore and Panichi (1980) and by Darling and Talbot (1992). This paper presents an empirical gas geothermometer formula using multidimensional approach. The formula was derived from 37 selected chemical data of the 5 production wells from the Awibengkok Geothermal Volcanic Field in West Java. Seven components, i.e., gas volume percentage, CO2, H2S, CH4, H2, N2, and NH3, from these data are utilize to developed three model equations which represent relationship between temperature and gas compositions. These formulas are then tested by several fumarolic chemical data from Sibual-buali Area (North Sumatera) and from Ringgit Area (South Sumatera). Preliminary result indicated that gas volume percentage, H2S and CO2 concentrations have a significant role in term of gas geothermometer. Further verification is currently in progress.

  6. Empirical particle transport model for tokamaks

    International Nuclear Information System (INIS)

    Petravic, M.; Kuo-Petravic, G.

    1986-08-01

    A simple empirical particle transport model has been constructed with the purpose of gaining insight into the L- to H-mode transition in tokamaks. The aim was to construct the simplest possible model which would reproduce the measured density profiles in the L-regime, and also produce a qualitatively correct transition to the H-regime without having to assume a completely different transport mode for the bulk of the plasma. Rather than using completely ad hoc constructions for the particle diffusion coefficient, we assume D = 1/5 chi/sub total/, where chi/sub total/ ≅ chi/sub e/ is the thermal diffusivity, and then use the κ/sub e/ = n/sub e/chi/sub e/ values derived from experiments. The observed temperature profiles are then automatically reproduced, but nontrivially, the correct density profiles are also obtained, for realistic fueling rates and profiles. Our conclusion is that it is sufficient to reduce the transport coefficients within a few centimeters of the surface to produce the H-mode behavior. An additional simple assumption, concerning the particle mean-free path, leads to a convective transport term which reverses sign a few centimeters inside the surface, as required by the H-mode density profiles

  7. Expert opinion vs. empirical evidence

    Science.gov (United States)

    Herman, Rod A; Raybould, Alan

    2014-01-01

    Expert opinion is often sought by government regulatory agencies when there is insufficient empirical evidence to judge the safety implications of a course of action. However, it can be reckless to continue following expert opinion when a preponderance of evidence is amassed that conflicts with this opinion. Factual evidence should always trump opinion in prioritizing the information that is used to guide regulatory policy. Evidence-based medicine has seen a dramatic upturn in recent years spurred by examples where evidence indicated that certain treatments recommended by expert opinions increased death rates. We suggest that scientific evidence should also take priority over expert opinion in the regulation of genetically modified crops (GM). Examples of regulatory data requirements that are not justified based on the mass of evidence are described, and it is suggested that expertise in risk assessment should guide evidence-based regulation of GM crops. PMID:24637724

  8. A Balanced Theoretical and Empirical Approach for the Development of a Design Support Tool

    DEFF Research Database (Denmark)

    Jensen, Thomas Aakjær; Hansen, Claus Thorp

    1996-01-01

    The introduction of a new design support system may change the engineering designer's work situation. Therefore, it may not be possible to derive all the functionalities for a design support system from solely empirical studies of manual design work. Alternatively the design support system could ...... system, indicating a proposal for how to balance a theoretical and empirical approach. The result of this research will be utilized in the development of a Designer's Workbench to support the synthesis activity in mechanical design....

  9. Appropriate methodologies for empirical bioethics: it's all relative.

    Science.gov (United States)

    Ives, Jonathan; Draper, Heather

    2009-05-01

    In this article we distinguish between philosophical bioethics (PB), descriptive policy orientated bioethics (DPOB) and normative policy oriented bioethics (NPOB). We argue that finding an appropriate methodology for combining empirical data and moral theory depends on what the aims of the research endeavour are, and that, for the most part, this combination is only required for NPOB. After briefly discussing the debate around the is/ought problem, and suggesting that both sides of this debate are misunderstanding one another (i.e. one side treats it as a conceptual problem, whilst the other treats it as an empirical claim), we outline and defend a methodological approach to NPOB based on work we have carried out on a project exploring the normative foundations of paternal rights and responsibilities. We suggest that given the prominent role already played by moral intuition in moral theory, one appropriate way to integrate empirical data and philosophical bioethics is to utilize empirically gathered lay intuition as the foundation for ethical reasoning in NPOB. The method we propose involves a modification of a long-established tradition on non-intervention in qualitative data gathering, combined with a form of reflective equilibrium where the demands of theory and data are given equal weight and a pragmatic compromise reached.

  10. An empirical algorithm to estimate spectral average cosine of underwater light field from remote sensing data in coastal oceanic waters.

    Digital Repository Service at National Institute of Oceanography (India)

    Talaulika, M.; Suresh, T.; Desa, E.S.; Inamdar, A.

    parameters from the coastal waters off Goa, India, and eastern Arabian Sea and the optical parameters derived using the radiative transfer code using these measured data. The algorithm was compared with two earlier reported empirical algorithms of Haltrin...

  11. Empirical yield tables for Minnesota.

    Science.gov (United States)

    Jerold T. Hahn; Gerhard K. Raile

    1982-01-01

    Describes the tables derived from the 1977 Forest Survey of Minnesota and presents examples of how the tables can be used. These tables are broken down according to Minnesota's four Forest Survey Units, 14 forest types, and 5 site index classes. Presents 210 of the 350 possible tables that contained sufficient data to justify publication.

  12. Statistical microeconomics and commodity prices: theory and empirical results.

    Science.gov (United States)

    Baaquie, Belal E

    2016-01-13

    A review is made of the statistical generalization of microeconomics by Baaquie (Baaquie 2013 Phys. A 392, 4400-4416. (doi:10.1016/j.physa.2013.05.008)), where the market price of every traded commodity, at each instant of time, is considered to be an independent random variable. The dynamics of commodity market prices is given by the unequal time correlation function and is modelled by the Feynman path integral based on an action functional. The correlation functions of the model are defined using the path integral. The existence of the action functional for commodity prices that was postulated to exist in Baaquie (Baaquie 2013 Phys. A 392, 4400-4416. (doi:10.1016/j.physa.2013.05.008)) has been empirically ascertained in Baaquie et al. (Baaquie et al. 2015 Phys. A 428, 19-37. (doi:10.1016/j.physa.2015.02.030)). The model's action functionals for different commodities has been empirically determined and calibrated using the unequal time correlation functions of the market commodity prices using a perturbation expansion (Baaquie et al. 2015 Phys. A 428, 19-37. (doi:10.1016/j.physa.2015.02.030)). Nine commodities drawn from the energy, metal and grain sectors are empirically studied and their auto-correlation for up to 300 days is described by the model to an accuracy of R(2)>0.90-using only six parameters. © 2015 The Author(s).

  13. Econometric Analysis of Financial Derivatives : An overview

    NARCIS (Netherlands)

    C-L. Chang (Chia-Lin); M.J. McAleer (Michael)

    2014-01-01

    markdownabstract__Abstract__ One of the fastest growing areas in empirical finance, and also one of the least rigorously analyzed, especially from a financial econometrics perspective, is the econometric analysis of financial derivatives, which are typically complicated and difficult to analyze.

  14. Econometric Analysis of Financial Derivatives: An Overview

    NARCIS (Netherlands)

    C-L. Chang (Chia-Lin); M.J. McAleer (Michael)

    2014-01-01

    markdownabstract__Abstract__ One of the fastest growing areas in empirical finance, and also one of the least rigorously analyzed, especially from a financial econometrics perspective, is the econometric analysis of financial derivatives, which are typically complicated and difficult to analyze.

  15. Risk Management and Financial Derivatives: An Overview

    NARCIS (Netherlands)

    S.M. Hammoudeh (Shawkat); M.J. McAleer (Michael)

    2012-01-01

    textabstractRisk management is crucial for optimal portfolio management. One of the fastest growing areas in empirical finance is the expansion of financial derivatives. The purpose of this special issue on “Risk Management and Financial Derivatives” is to highlight some areas in which novel

  16. Pluvials, droughts, the Mongol Empire, and modern Mongolia.

    Science.gov (United States)

    Pederson, Neil; Hessl, Amy E; Baatarbileg, Nachin; Anchukaitis, Kevin J; Di Cosmo, Nicola

    2014-03-25

    Although many studies have associated the demise of complex societies with deteriorating climate, few have investigated the connection between an ameliorating environment, surplus resources, energy, and the rise of empires. The 13th-century Mongol Empire was the largest contiguous land empire in world history. Although drought has been proposed as one factor that spurred these conquests, no high-resolution moisture data are available during the rapid development of the Mongol Empire. Here we present a 1,112-y tree-ring reconstruction of warm-season water balance derived from Siberian pine (Pinus sibirica) trees in central Mongolia. Our reconstruction accounts for 56% of the variability in the regional water balance and is significantly correlated with steppe productivity across central Mongolia. In combination with a gridded temperature reconstruction, our results indicate that the regional climate during the conquests of Chinggis Khan's (Genghis Khan's) 13th-century Mongol Empire was warm and persistently wet. This period, characterized by 15 consecutive years of above-average moisture in central Mongolia and coinciding with the rise of Chinggis Khan, is unprecedented over the last 1,112 y. We propose that these climate conditions promoted high grassland productivity and favored the formation of Mongol political and military power. Tree-ring and meteorological data also suggest that the early 21st-century drought in central Mongolia was the hottest drought in the last 1,112 y, consistent with projections of warming over Inner Asia. Future warming may overwhelm increases in precipitation leading to similar heat droughts, with potentially severe consequences for modern Mongolia.

  17. Pluvials, droughts, the Mongol Empire, and modern Mongolia

    Science.gov (United States)

    Pederson, Neil; Hessl, Amy E.; Baatarbileg, Nachin; Anchukaitis, Kevin J.; Di Cosmo, Nicola

    2014-01-01

    Although many studies have associated the demise of complex societies with deteriorating climate, few have investigated the connection between an ameliorating environment, surplus resources, energy, and the rise of empires. The 13th-century Mongol Empire was the largest contiguous land empire in world history. Although drought has been proposed as one factor that spurred these conquests, no high-resolution moisture data are available during the rapid development of the Mongol Empire. Here we present a 1,112-y tree-ring reconstruction of warm-season water balance derived from Siberian pine (Pinus sibirica) trees in central Mongolia. Our reconstruction accounts for 56% of the variability in the regional water balance and is significantly correlated with steppe productivity across central Mongolia. In combination with a gridded temperature reconstruction, our results indicate that the regional climate during the conquests of Chinggis Khan’s (Genghis Khan’s) 13th-century Mongol Empire was warm and persistently wet. This period, characterized by 15 consecutive years of above-average moisture in central Mongolia and coinciding with the rise of Chinggis Khan, is unprecedented over the last 1,112 y. We propose that these climate conditions promoted high grassland productivity and favored the formation of Mongol political and military power. Tree-ring and meteorological data also suggest that the early 21st-century drought in central Mongolia was the hottest drought in the last 1,112 y, consistent with projections of warming over Inner Asia. Future warming may overwhelm increases in precipitation leading to similar heat droughts, with potentially severe consequences for modern Mongolia. PMID:24616521

  18. Pluvials, droughts, the Mongol Empire, and modern Mongolia

    Science.gov (United States)

    Pederson, Neil; Hessl, Amy E.; Baatarbileg, Nachin; Anchukaitis, Kevin J.; Di Cosmo, Nicola

    2014-03-01

    Although many studies have associated the demise of complex societies with deteriorating climate, few have investigated the connection between an ameliorating environment, surplus resources, energy, and the rise of empires. The 13th-century Mongol Empire was the largest contiguous land empire in world history. Although drought has been proposed as one factor that spurred these conquests, no high-resolution moisture data are available during the rapid development of the Mongol Empire. Here we present a 1,112-y tree-ring reconstruction of warm-season water balance derived from Siberian pine (Pinus sibirica) trees in central Mongolia. Our reconstruction accounts for 56% of the variability in the regional water balance and is significantly correlated with steppe productivity across central Mongolia. In combination with a gridded temperature reconstruction, our results indicate that the regional climate during the conquests of Chinggis Khan's (Genghis Khan's) 13th-century Mongol Empire was warm and persistently wet. This period, characterized by 15 consecutive years of above-average moisture in central Mongolia and coinciding with the rise of Chinggis Khan, is unprecedented over the last 1,112 y. We propose that these climate conditions promoted high grassland productivity and favored the formation of Mongol political and military power. Tree-ring and meteorological data also suggest that the early 21st-century drought in central Mongolia was the hottest drought in the last 1,112 y, consistent with projections of warming over Inner Asia. Future warming may overwhelm increases in precipitation leading to similar heat droughts, with potentially severe consequences for modern Mongolia.

  19. An Empirical Investigation of External Debt - Military Expenditure Nexus in Bangladesh

    Directory of Open Access Journals (Sweden)

    Khalid ZAMAN

    2012-06-01

    Full Text Available The objective of this paper is to empirically investigate a two-way statistical relationship between the real external debt and real military expenditure in the context of Bangladesh. A time series co-integration and Granger causality tests have been employed from 1980 - 2009 for analysis. The empirical results support the bi-directional causality between the external debt and economic growth, while unidirectional causality runs from military spending to external debt.

  20. An Empirical Mass Function Distribution

    Science.gov (United States)

    Murray, S. G.; Robotham, A. S. G.; Power, C.

    2018-03-01

    The halo mass function, encoding the comoving number density of dark matter halos of a given mass, plays a key role in understanding the formation and evolution of galaxies. As such, it is a key goal of current and future deep optical surveys to constrain the mass function down to mass scales that typically host {L}\\star galaxies. Motivated by the proven accuracy of Press–Schechter-type mass functions, we introduce a related but purely empirical form consistent with standard formulae to better than 4% in the medium-mass regime, {10}10{--}{10}13 {h}-1 {M}ȯ . In particular, our form consists of four parameters, each of which has a simple interpretation, and can be directly related to parameters of the galaxy distribution, such as {L}\\star . Using this form within a hierarchical Bayesian likelihood model, we show how individual mass-measurement errors can be successfully included in a typical analysis, while accounting for Eddington bias. We apply our form to a question of survey design in the context of a semi-realistic data model, illustrating how it can be used to obtain optimal balance between survey depth and angular coverage for constraints on mass function parameters. Open-source Python and R codes to apply our new form are provided at http://mrpy.readthedocs.org and https://cran.r-project.org/web/packages/tggd/index.html respectively.

  1. Using Empirical Data To Build An Advisory Tool For Ecodesign

    DEFF Research Database (Denmark)

    McAloone, Timothy Charles; Evans, S.

    1999-01-01

    allows for the consideration of environmental issues in every stage of the product development process, an exploratory study sought to identify the various stages that companies travelled through when implementing eco-design principles. The electrical/electronics industry was the chosen subject...... for the study.Results from this empirical research revealed that there is a common sequence of events that many companies go through when integrating eco-design into their product development processes, as presented in the model of eco-design integration in this paper. This sequence of events would be easily...... recognised by change management practitioners. Further to the common sequence of change in the companies, it was found that there were also common issues which companies aimed to improve when attempting to learn more about eco-design.Plotting the model of eco-design integration against the common issues...

  2. Empirical STORM-E Model. [I. Theoretical and Observational Basis

    Science.gov (United States)

    Mertens, Christopher J.; Xu, Xiaojing; Bilitza, Dieter; Mlynczak, Martin G.; Russell, James M., III

    2013-01-01

    Auroral nighttime infrared emission observed by the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument onboard the Thermosphere-Ionosphere-Mesosphere Energetics and Dynamics (TIMED) satellite is used to develop an empirical model of geomagnetic storm enhancements to E-region peak electron densities. The empirical model is called STORM-E and will be incorporated into the 2012 release of the International Reference Ionosphere (IRI). The proxy for characterizing the E-region response to geomagnetic forcing is NO+(v) volume emission rates (VER) derived from the TIMED/SABER 4.3 lm channel limb radiance measurements. The storm-time response of the NO+(v) 4.3 lm VER is sensitive to auroral particle precipitation. A statistical database of storm-time to climatological quiet-time ratios of SABER-observed NO+(v) 4.3 lm VER are fit to widely available geomagnetic indices using the theoretical framework of linear impulse-response theory. The STORM-E model provides a dynamic storm-time correction factor to adjust a known quiescent E-region electron density peak concentration for geomagnetic enhancements due to auroral particle precipitation. Part II of this series describes the explicit development of the empirical storm-time correction factor for E-region peak electron densities, and shows comparisons of E-region electron densities between STORM-E predictions and incoherent scatter radar measurements. In this paper, Part I of the series, the efficacy of using SABER-derived NO+(v) VER as a proxy for the E-region response to solar-geomagnetic disturbances is presented. Furthermore, a detailed description of the algorithms and methodologies used to derive NO+(v) VER from SABER 4.3 lm limb emission measurements is given. Finally, an assessment of key uncertainties in retrieving NO+(v) VER is presented

  3. Causal Diagrams for Empirical Research

    OpenAIRE

    Pearl, Judea

    1994-01-01

    The primary aim of this paper is to show how graphical models can be used as a mathematical language for integrating statistical and subject-matter information. In particular, the paper develops a principled, nonparametric framework for causal inference, in which diagrams are queried to determine if the assumptions available are sufficient for identifiying causal effects from non-experimental data. If so the diagrams can be queried to produce mathematical expressions for causal effects in ter...

  4. [Normative-empirical determination of personnel requirements in psychosomatic medicine and psychotherapy].

    Science.gov (United States)

    Heuft, Gereon; Hochlehnert, Achim; Barufka, Steffi; Nikendei, Christoph; Kruse, Johannes; Zipfel, Stephan; Hofmann, Tobias; Hildenbrand, Gerhard; Cuntz, Ulrich; Herzog, Wolfgang; Heller, Michael

    2015-01-01

    There is a high degree of misallocated medical care for patients with somatoform disorders and patients with concomitant mental diseases. This complex of problems could be reduced remarkably by integrating psychosomatic departments into hospitals with maximum medical care. Admitting a few big psychosomatic specialist clinics into the calculation basis decreased the Day-Mix Index (DMI). The massive reduction of the calculated costs per day leads to a gap in funding resulting in a loss of the necessary personnel requirements - at least in university psychosomatic departments. The objective of this article is therefore to empirically verify the reference numbers of personnel resources calculated on the basis of the new German lump-sum reimbursement system in psychiatry and psychosomatics (PEPP). The minute values of the reference numbers of Heuft (1999) are contrasted with the minute values of the PEPP reimbursement system in the years 2013 and 2014, as calculated by the Institute for Payment Systems in Hospitals (InEK). The minute values derived from the PEPP data show a remarkable convergence with the minute values of Heuft's reference numbers (1999). A pure pricing system like the PEPP reimbursement system as designed so far threatens empirically verifiable and qualified personnel requirements of psychosomatic departments. In order to ensure the necessary therapy dosage and display it in minute values according to the valid OPS procedure codes, the minimum limit of the reference numbers is mandatory to maintain the substance of psychosomatic care. Based on the present calculation, a base rate of at least 285 e has to be politically demanded. Future developments in personnel costs have to be refinanced at 100 %.

  5. Integral Presentations of Catalan Numbers

    Science.gov (United States)

    Dana-Picard, Thierry

    2010-01-01

    We compute in three different ways the same definite parametric integral. By-products are the derivation of a combinatorial identity and two integral presentations of Catalan numbers. One of them leads to a presentation using the [gamma] function.

  6. Essays on empirical likelihood in economics

    NARCIS (Netherlands)

    Gao, Z.

    2012-01-01

    This thesis intends to exploit the roots of empirical likelihood and its related methods in mathematical programming and computation. The roots will be connected and the connections will induce new solutions for the problems of estimation, computation, and generalization of empirical likelihood.

  7. Empirical training for conditional random fields

    NARCIS (Netherlands)

    Zhu, Zhemin; Hiemstra, Djoerd; Apers, Peter M.G.; Wombacher, Andreas

    2013-01-01

    In this paper (Zhu et al., 2013), we present a practi- cally scalable training method for CRFs called Empir- ical Training (EP). We show that the standard train- ing with unregularized log likelihood can have many maximum likelihood estimations (MLEs). Empirical training has a unique closed form MLE

  8. Intermodal connectivity in Europe, an empirical exploration

    NARCIS (Netherlands)

    de Langen, P.W.; Lases Figueroa, D.M.; van Donselaar, K.H.; Bozuwa, J.

    2017-01-01

    In this paper we analyse the intermodal connectivity in Europe. The empirical analysis is to our knowledge the first empirical analysis of intermodal connections, and is based on a comprehensive database of intermodal connections in Europe. The paper focuses on rail and barge services, as they are

  9. Empirical Moral Philosophy and Teacher Education

    Science.gov (United States)

    Schjetne, Espen; Afdal, Hilde Wågsås; Anker, Trine; Johannesen, Nina; Afdal, Geir

    2016-01-01

    In this paper, we explore the possible contributions of empirical moral philosophy to professional ethics in teacher education. We argue that it is both possible and desirable to connect knowledge of how teachers empirically do and understand professional ethics with normative theories of teachers' professional ethics. Our argument is made in…

  10. Empirical ethics, context-sensitivity, and contextualism.

    Science.gov (United States)

    Musschenga, Albert W

    2005-10-01

    In medical ethics, business ethics, and some branches of political philosophy (multi-culturalism, issues of just allocation, and equitable distribution) the literature increasingly combines insights from ethics and the social sciences. Some authors in medical ethics even speak of a new phase in the history of ethics, hailing "empirical ethics" as a logical next step in the development of practical ethics after the turn to "applied ethics." The name empirical ethics is ill-chosen because of its associations with "descriptive ethics." Unlike descriptive ethics, however, empirical ethics aims to be both descriptive and normative. The first question on which I focus is what kind of empirical research is used by empirical ethics and for which purposes. I argue that the ultimate aim of all empirical ethics is to improve the context-sensitivity of ethics. The second question is whether empirical ethics is essentially connected with specific positions in meta-ethics. I show that in some kinds of meta-ethical theories, which I categorize as broad contextualist theories, there is an intrinsic need for connecting normative ethics with empirical social research. But context-sensitivity is a goal that can be aimed for from any meta-ethical position.

  11. The emerging empirics of evolutionary economic geography

    NARCIS (Netherlands)

    Boschma, R.A.; Frenken, K.

    2011-01-01

    Following last decade’s programmatic papers on Evolutionary Economic Geography, we report on recent empirical advances and how this empirical work can be positioned vis-a`-vis other strands of research in economic geography. First, we review studies on the path dependent nature of clustering, and

  12. The emerging empirics of evolutionary economic geography

    NARCIS (Netherlands)

    Boschma, R.A.; Frenken, K.

    2010-01-01

    Following last decade’s programmatic papers on Evolutionary Economic Geography, we report on recent empirical advances and how this empirical work can be positioned vis-à-vis other strands of research in economic geography. First, we review studies on the path dependent nature of clustering, and how

  13. The emerging empirics of evolutionary economic geography.

    NARCIS (Netherlands)

    Boschma, R.A.; Frenken, K.

    2011-01-01

    Following last decade’s programmatic papers on Evolutionary Economic Geography, we report on recent empirical advances and how this empirical work can be positioned vis-a`-vis other strands of research in economic geography. First, we review studies on the path dependent nature of clustering, and

  14. Empirical high-latitude electric field models

    International Nuclear Information System (INIS)

    Heppner, J.P.; Maynard, N.C.

    1987-01-01

    Electric field measurements from the Dynamics Explorer 2 satellite have been analyzed to extend the empirical models previously developed from dawn-dusk OGO 6 measurements (J.P. Heppner, 1977). The analysis embraces large quantities of data from polar crossings entering and exiting the high latitudes in all magnetic local time zones. Paralleling the previous analysis, the modeling is based on the distinctly different polar cap and dayside convective patterns that occur as a function of the sign of the Y component of the interplanetary magnetic field. The objective, which is to represent the typical distributions of convective electric fields with a minimum number of characteristic patterns, is met by deriving one pattern (model BC) for the northern hemisphere with a +Y interplanetary magnetic field (IMF) and southern hemisphere with a -Y IMF and two patterns (models A and DE) for the northern hemisphere with a -Y IMF and southern hemisphere with a +Y IMF. The most significant large-scale revisions of the OGO 6 models are (1) on the dayside where the latitudinal overlap of morning and evening convection cells reverses with the sign of the IMF Y component, (2) on the nightside where a westward flow region poleward from the Harang discontinuity appears under model BC conditions, and (3) magnetic local time shifts in the positions of the convection cell foci. The modeling above was followed by a detailed examination of cases where the IMF Z component was clearly positive (northward). Neglecting the seasonally dependent cases where irregularities obscure pattern recognition, the observations range from reasonable agreement with the new BC and DE models, to cases where different characteristics appeared primarily at dayside high latitudes

  15. The Role of Empirical Research in Bioethics

    Science.gov (United States)

    Kon, Alexander A.

    2010-01-01

    There has long been tension between bioethicists whose work focuses on classical philosophical inquiry and those who perform empirical studies on bioethical issues. While many have argued that empirical research merely illuminates current practices and cannot inform normative ethics, others assert that research-based work has significant implications for refining our ethical norms. In this essay, I present a novel construct for classifying empirical research in bioethics into four hierarchical categories: Lay of the Land, Ideal Versus Reality, Improving Care, and Changing Ethical Norms. Through explaining these four categories and providing examples of publications in each stratum, I define how empirical research informs normative ethics. I conclude by demonstrating how philosophical inquiry and empirical research can work cooperatively to further normative ethics. PMID:19998120

  16. Sinabro: A Smartphone-Integrated Opportunistic Electrocardiogram Monitoring System.

    Science.gov (United States)

    Kwon, Sungjun; Lee, Dongseok; Kim, Jeehoon; Lee, Youngki; Kang, Seungwoo; Seo, Sangwon; Park, Kwangsuk

    2016-03-11

    In our preliminary study, we proposed a smartphone-integrated, unobtrusive electrocardiogram (ECG) monitoring system, Sinabro, which monitors a user's ECG opportunistically during daily smartphone use without explicit user intervention. The proposed system also monitors ECG-derived features, such as heart rate (HR) and heart rate variability (HRV), to support the pervasive healthcare apps for smartphones based on the user's high-level contexts, such as stress and affective state levels. In this study, we have extended the Sinabro system by: (1) upgrading the sensor device; (2) improving the feature extraction process; and (3) evaluating extensions of the system. We evaluated these extensions with a good set of algorithm parameters that were suggested based on empirical analyses. The results showed that the system could capture ECG reliably and extract highly accurate ECG-derived features with a reasonable rate of data drop during the user's daily smartphone use.

  17. Sinabro: A Smartphone-Integrated Opportunistic Electrocardiogram Monitoring System

    Directory of Open Access Journals (Sweden)

    Sungjun Kwon

    2016-03-01

    Full Text Available In our preliminary study, we proposed a smartphone-integrated, unobtrusive electrocardiogram (ECG monitoring system, Sinabro, which monitors a user’s ECG opportunistically during daily smartphone use without explicit user intervention. The proposed system also monitors ECG-derived features, such as heart rate (HR and heart rate variability (HRV, to support the pervasive healthcare apps for smartphones based on the user’s high-level contexts, such as stress and affective state levels. In this study, we have extended the Sinabro system by: (1 upgrading the sensor device; (2 improving the feature extraction process; and (3 evaluating extensions of the system. We evaluated these extensions with a good set of algorithm parameters that were suggested based on empirical analyses. The results showed that the system could capture ECG reliably and extract highly accurate ECG-derived features with a reasonable rate of data drop during the user’s daily smartphone use.

  18. Empirical modeling of dynamic behaviors of pneumatic artificial muscle actuators.

    Science.gov (United States)

    Wickramatunge, Kanchana Crishan; Leephakpreeda, Thananchai

    2013-11-01

    Pneumatic Artificial Muscle (PAM) actuators yield muscle-like mechanical actuation with high force to weight ratio, soft and flexible structure, and adaptable compliance for rehabilitation and prosthetic appliances to the disabled as well as humanoid robots or machines. The present study is to develop empirical models of the PAM actuators, that is, a PAM coupled with pneumatic control valves, in order to describe their dynamic behaviors for practical control design and usage. Empirical modeling is an efficient approach to computer-based modeling with observations of real behaviors. Different characteristics of dynamic behaviors of each PAM actuator are due not only to the structures of the PAM actuators themselves, but also to the variations of their material properties in manufacturing processes. To overcome the difficulties, the proposed empirical models are experimentally derived from real physical behaviors of the PAM actuators, which are being implemented. In case studies, the simulated results with good agreement to experimental results, show that the proposed methodology can be applied to describe the dynamic behaviors of the real PAM actuators. Copyright © 2013 ISA. Published by Elsevier Ltd. All rights reserved.

  19. Empirical complexities in the genetic foundations of lethal mutagenesis.

    Science.gov (United States)

    Bull, James J; Joyce, Paul; Gladstone, Eric; Molineux, Ian J

    2013-10-01

    From population genetics theory, elevating the mutation rate of a large population should progressively reduce average fitness. If the fitness decline is large enough, the population will go extinct in a process known as lethal mutagenesis. Lethal mutagenesis has been endorsed in the virology literature as a promising approach to viral treatment, and several in vitro studies have forced viral extinction with high doses of mutagenic drugs. Yet only one empirical study has tested the genetic models underlying lethal mutagenesis, and the theory failed on even a qualitative level. Here we provide a new level of analysis of lethal mutagenesis by developing and evaluating models specifically tailored to empirical systems that may be used to test the theory. We first quantify a bias in the estimation of a critical parameter and consider whether that bias underlies the previously observed lack of concordance between theory and experiment. We then consider a seemingly ideal protocol that avoids this bias-mutagenesis of virions-but find that it is hampered by other problems. Finally, results that reveal difficulties in the mere interpretation of mutations assayed from double-strand genomes are derived. Our analyses expose unanticipated complexities in testing the theory. Nevertheless, the previous failure of the theory to predict experimental outcomes appears to reside in evolutionary mechanisms neglected by the theory (e.g., beneficial mutations) rather than from a mismatch between the empirical setup and model assumptions. This interpretation raises the specter that naive attempts at lethal mutagenesis may augment adaptation rather than retard it.

  20. Protein-Ligand Empirical Interaction Components for Virtual Screening.

    Science.gov (United States)

    Yan, Yuna; Wang, Weijun; Sun, Zhaoxi; Zhang, John Z H; Ji, Changge

    2017-08-28

    A major shortcoming of empirical scoring functions is that they often fail to predict binding affinity properly. Removing false positives of docking results is one of the most challenging works in structure-based virtual screening. Postdocking filters, making use of all kinds of experimental structure and activity information, may help in solving the issue. We describe a new method based on detailed protein-ligand interaction decomposition and machine learning. Protein-ligand empirical interaction components (PLEIC) are used as descriptors for support vector machine learning to develop a classification model (PLEIC-SVM) to discriminate false positives from true positives. Experimentally derived activity information is used for model training. An extensive benchmark study on 36 diverse data sets from the DUD-E database has been performed to evaluate the performance of the new method. The results show that the new method performs much better than standard empirical scoring functions in structure-based virtual screening. The trained PLEIC-SVM model is able to capture important interaction patterns between ligand and protein residues for one specific target, which is helpful in discarding false positives in postdocking filtering.

  1. Explaining Innovation. An Empirical Analysis of Industry Data from Norway

    Directory of Open Access Journals (Sweden)

    Torbjørn Lorentzen

    2016-01-01

    Full Text Available The objective of the paper is to analyse why some firms innovate while others do not. The paper combines different theories of innovation by relating innovation to internal, firm specific assets and external, regional factors. Hypotheses are derived from theories and tested empirically by using logistic regression. The empirical analysis indicates that internal funding of R&D and size of the firm are the most important firm specific attributes for successful innovation. External, regional factors are also important. The analysis shows that firms located in large urban regions have significantly higher innovation rates than firms located in the periphery, and firms involved in regional networking are more likely to innovate compared to firms not involved in networking. The analysis contributes to a theoretical and empirical understanding of factors that influence on innovation and the role innovation plays in the market economy. Innovation policy should be targeted at developing a tax system and building infrastructure which give firms incentives to invest and allocate internal resources to R&D-activities and collaborate with others in innovation. From an economic policy perspective, consideration should be given to allocating more public resources to rural areas in order to compensate for the asymmetric distribution of resources between the centre and periphery. The paper contributes to the scientific literature of innovation by combining the firm oriented perspective with weight on firm specific, internal resources and a system perspective which focuses on external resources and networking as the most important determinants of innovation in firms.

  2. An Enduring Dialogue between Computational and Empirical Vision.

    Science.gov (United States)

    Martinez-Conde, Susana; Macknik, Stephen L; Heeger, David J

    2018-04-01

    In the late 1970s, key discoveries in neurophysiology, psychophysics, computer vision, and image processing had reached a tipping point that would shape visual science for decades to come. David Marr and Ellen Hildreth's 'Theory of edge detection', published in 1980, set out to integrate the newly available wealth of data from behavioral, physiological, and computational approaches in a unifying theory. Although their work had wide and enduring ramifications, their most important contribution may have been to consolidate the foundations of the ongoing dialogue between theoretical and empirical vision science. Copyright © 2018 Elsevier Ltd. All rights reserved.

  3. Empirical essays on energy economics

    Energy Technology Data Exchange (ETDEWEB)

    Thoenes, Stefan

    2013-06-13

    The main part of this thesis consists of three distinct essays that empirically analyze economic issues related to energy markets in the United States and Europe. The first chapter provides an introduction and discusses the motivation for the different analyses pursued in this thesis. The second chapter examines attention effects in the market for hybrid vehicles. We show that local media coverage, gasoline price changes and unprecedented record gasoline prices have a significant impact on the consumers' attention. As attention is not directly observable, we analyze online search behavior as a proxy for the revealed consumer attention. Our study is based on a unique weekly panel dataset for 19 metropolitan areas in the US. Additionally, we use monthly state-level panel data to show that the adoption rate of hybrid vehicles is robustly related to our measure of attention. Our results show that the consumers' attention fluctuates strongly and systematically. The third chapter shows how the effect of fuel prices varies with the level of electricity demand. It analyzes the relationship between daily prices of electricity, natural gas and carbon emission allowances with a semiparametric varying smooth coefficient cointegration model. This model is used to analyze the market impact of the nuclear moratorium by the German Government in March 2011. Futures prices of electricity, natural gas and emission allowances are used to show that the market efficiently accounts for the suspended capacity and correctly expects that several nuclear plants will not be switched on after the moratorium. In the fourth chapter, we develop a structural vector autoregressive model (VAR) for the German natural gas market. In particular, we illustrate the usefulness of our approach by disentangling the effects of different fundamental influences during four specific events: The financial crisis starting in 2008, the Russian-Ukrainian gas dispute in January 2009, the Libyan civil war

  4. Empirical essays on energy economics

    International Nuclear Information System (INIS)

    Thoenes, Stefan

    2013-01-01

    The main part of this thesis consists of three distinct essays that empirically analyze economic issues related to energy markets in the United States and Europe. The first chapter provides an introduction and discusses the motivation for the different analyses pursued in this thesis. The second chapter examines attention effects in the market for hybrid vehicles. We show that local media coverage, gasoline price changes and unprecedented record gasoline prices have a significant impact on the consumers' attention. As attention is not directly observable, we analyze online search behavior as a proxy for the revealed consumer attention. Our study is based on a unique weekly panel dataset for 19 metropolitan areas in the US. Additionally, we use monthly state-level panel data to show that the adoption rate of hybrid vehicles is robustly related to our measure of attention. Our results show that the consumers' attention fluctuates strongly and systematically. The third chapter shows how the effect of fuel prices varies with the level of electricity demand. It analyzes the relationship between daily prices of electricity, natural gas and carbon emission allowances with a semiparametric varying smooth coefficient cointegration model. This model is used to analyze the market impact of the nuclear moratorium by the German Government in March 2011. Futures prices of electricity, natural gas and emission allowances are used to show that the market efficiently accounts for the suspended capacity and correctly expects that several nuclear plants will not be switched on after the moratorium. In the fourth chapter, we develop a structural vector autoregressive model (VAR) for the German natural gas market. In particular, we illustrate the usefulness of our approach by disentangling the effects of different fundamental influences during four specific events: The financial crisis starting in 2008, the Russian-Ukrainian gas dispute in January 2009, the Libyan civil war in 2011 as

  5. Pluvials, Droughts, the Mongol Empire, and Modern Mongolia

    Science.gov (United States)

    Hessl, A. E.; Pederson, N.; Baatarbileg, N.; Anchukaitis, K. J.

    2013-12-01

    Understanding the connections between climate, ecosystems, and society during historical and modern climatic transitions requires annual resolution records with high fidelity climate signals. Many studies link the demise of complex societies with deteriorating climate conditions, but few have investigated the connection between climate, surplus energy, and the rise of empires. Inner Asia in the 13th century underwent a major political transformation requiring enormous energetic inputs that altered human history. The Mongol Empire, centered on the city of Karakorum, became the largest contiguous land empire in world history (Fig. 1 inset). Powered by domesticated grazing animals, the empire grew at the expense of sedentary agriculturalists across Asia, the Middle East, and Eastern Europe. Although some scholars and conventional wisdom agree that dry conditions spurred the Mongol conquests, little paleoenvironmental data at annual resolution are available to evaluate the role of climate in the development of the Mongol Empire. Here we present a 2600 year tree-ring reconstruction of warm-season, self-calibrating Palmer Drought Severity Index (scPDSI), a measure of water balance, derived from 107 live and dead Siberian pine (Pinus sibirica) trees growing on a Holocene lava flow in central Mongolia. Trees growing on the Khorgo lava flow today are stunted and widely spaced, occurring on microsites with little to no soil development. These trees are extremely water-stressed and their radial growth is well-correlated with both drought (scPDSI) and grassland productivity (Normalized Difference Vegetation Index (NDVI)). Our reconstruction, calibrated and validated on instrumental June-September scPDSI (1959-2009) accounts for 55.8% of the variability in the regional scPDSI when 73% of the annual rainfall occurs. Our scPDSI reconstruction places historic and modern social change in Mongolia in the context of the range of climatic variability during the Common Era. Our record

  6. Semi-empirical corrosion model for Zircaloy-4 cladding

    International Nuclear Information System (INIS)

    Nadeem Elahi, Waseem; Atif Rana, Muhammad

    2015-01-01

    The Zircaloy-4 cladding tube in Pressurize Water Reactors (PWRs) bears corrosion due to fast neutron flux, coolant temperature, and water chemistry. The thickness of Zircaloy-4 cladding tube may be decreased due to the increase in corrosion penetration which may affect the integrity of the fuel rod. The tin content and inter-metallic particles sizes has been found significantly in the magnitude of oxide thickness. In present study we have developed a Semiempirical corrosion model by modifying the Arrhenius equation for corrosion as a function of acceleration factor for tin content and accumulative annealing. This developed model has been incorporated into fuel performance computer code. The cladding oxide thickness data obtained from the Semi-empirical corrosion model has been compared with the experimental results i.e., numerous cases of measured cladding oxide thickness from UO 2 fuel rods, irradiated in various PWRs. The results of the both studies lie within the error band of 20μm, which confirms the validity of the developed Semi-empirical corrosion model. Key words: Corrosion, Zircaloy-4, tin content, accumulative annealing factor, Semi-empirical, PWR. (author)

  7. Empirical method to calculate Clinch River Breeder Reactor (CRBR) inlet plenum transient temperatures

    International Nuclear Information System (INIS)

    Howarth, W.L.

    1976-01-01

    Sodium flow enters the CRBR inlet plenum via three loops or inlets. An empirical equation was developed to calculate transient temperatures in the CRBR inlet plenum from known loop flows and temperatures. The constants in the empirical equation were derived from 1/4 scale Inlet Plenum Model tests using water as the test fluid. The sodium temperature distribution was simulated by an electrolyte. Step electrolyte transients at 100 percent model flow were used to calculate the equation constants. Step electrolyte runs at 50 percent and 10 percent flow confirmed that the constants were independent of flow. Also, a transient was tested which varied simultaneously flow rate and electrolyte. Agreement of the test results with the empirical equation results was good which verifies the empirical equation

  8. Physico-empirical approach for mapping soil hydraulic behaviour

    Directory of Open Access Journals (Sweden)

    G. D'Urso

    1997-01-01

    Full Text Available Abstract: Pedo-transfer functions are largely used in soil hydraulic characterisation of large areas. The use of physico-empirical approaches for the derivation of soil hydraulic parameters from disturbed samples data can be greatly enhanced if a characterisation performed on undisturbed cores of the same type of soil is available. In this study, an experimental procedure for deriving maps of soil hydraulic behaviour is discussed with reference to its application in an irrigation district (30 km2 in southern Italy. The main steps of the proposed procedure are: i the precise identification of soil hydraulic functions from undisturbed sampling of main horizons in representative profiles for each soil map unit; ii the determination of pore-size distribution curves from larger disturbed sampling data sets within the same soil map unit. iii the calibration of physical-empirical methods for retrieving soil hydraulic parameters from particle-size data and undisturbed soil sample analysis; iv the definition of functional hydraulic properties from water balance output; and v the delimitation of soil hydraulic map units based on functional properties.

  9. Deriving Empirically-Based Design Guidelines for Advanced Learning Technologies that Foster Disciplinary Comprehension / Définir des lignes directrices fondées sur des données empiriques pour les technologies d’apprentissage avancé qui favorisent la compr

    Directory of Open Access Journals (Sweden)

    Eric Poitras

    2012-02-01

    Full Text Available Planning, conducting, and reporting leading-edge research requires professionals who are capable of highly skilled reading. This study reports the development of an empirically informed computer-based learning environment designed to foster the acquisition of reading comprehension strategies that mediate expertise in the social sciences. Empirical data were gathered in a mixed-methods explanatory sequential design that examined the reading comprehension strategies used by an expert social scientist while reading a professional-level text. Process data were collected through a concurrent think-aloud protocol and coded according to reading comprehension processes. We combined both quantitative and qualitative analyses to identify, describe, and explain patterns in the expert’s use of reading strategies. Our findings indicate that highly-skilled reading is characterized by critiquing text information, relating information to prior knowledge, and evaluating one’s own understanding of text information. Findings are used to inform the design of worked-examples and a pedagogical agent embedded within the Highly-Skilled Reading Tutor. Le type de planification, de réalisation et l’analyse qui caractérise une recherche d’avant-garde nécessite des professionnels en mesure d’effectuer des lectures hautement spécialisées. La présente étude dresse un rapport sur l’élaboration d’un milieu d’apprentissage informatisé conçu pour favoriser l’acquisition de stratégies de compréhension en lecture permettant d’assurer la transmission des connaissances spécialisées en sciences sociales. La collecte de données empiriques s’est effectuée suivant une conception séquentielle explicative fondée sur une méthode mixte, qui étudiait les stratégies de compréhension de lecture utilisées par un expert en sciences sociales lors de sa lecture d’un texte de calibre professionnel. La collecte des données sur le processus s

  10. Empirical projection-based basis-component decomposition method

    Science.gov (United States)

    Brendel, Bernhard; Roessl, Ewald; Schlomka, Jens-Peter; Proksa, Roland

    2009-02-01

    Advances in the development of semiconductor based, photon-counting x-ray detectors stimulate research in the domain of energy-resolving pre-clinical and clinical computed tomography (CT). For counting detectors acquiring x-ray attenuation in at least three different energy windows, an extended basis component decomposition can be performed in which in addition to the conventional approach of Alvarez and Macovski a third basis component is introduced, e.g., a gadolinium based CT contrast material. After the decomposition of the measured projection data into the basis component projections, conventional filtered-backprojection reconstruction is performed to obtain the basis-component images. In recent work, this basis component decomposition was obtained by maximizing the likelihood-function of the measurements. This procedure is time consuming and often unstable for excessively noisy data or low intrinsic energy resolution of the detector. Therefore, alternative procedures are of interest. Here, we introduce a generalization of the idea of empirical dual-energy processing published by Stenner et al. to multi-energy, photon-counting CT raw data. Instead of working in the image-domain, we use prior spectral knowledge about the acquisition system (tube spectra, bin sensitivities) to parameterize the line-integrals of the basis component decomposition directly in the projection domain. We compare this empirical approach with the maximum-likelihood (ML) approach considering image noise and image bias (artifacts) and see that only moderate noise increase is to be expected for small bias in the empirical approach. Given the drastic reduction of pre-processing time, the empirical approach is considered a viable alternative to the ML approach.

  11. An Empirical Typology of Narcissism and Mental Health in Late Adolescence

    Science.gov (United States)

    Lapsley, Daniel K.; Aalsma, Matthew C.

    2006-01-01

    A two-step cluster analytic strategy was used in two studies to identify an empirically derived typology of narcissism in late adolescence. In Study 1, late adolescents (N=204) responded to the profile of narcissistic dispositions and measures of grandiosity (''superiority'') and idealization (''goal instability'') inspired by Kohut's theory,…

  12. Empirical rate equation model and rate calculations of hydrogen generation for Hanford tank waste

    International Nuclear Information System (INIS)

    HU, T.A.

    1999-01-01

    Empirical rate equations are derived to estimate hydrogen generation based on chemical reactions, radiolysis of water and organic compounds, and corrosion processes. A comparison of the generation rates observed in the field with the rates calculated for twenty eight tanks shows agreement within a factor of two to three

  13. An empirical InSAR-optical fusion approach to mapping vegetation canopy height

    Science.gov (United States)

    Wayne S. Walker; Josef M. Kellndorfer; Elizabeth LaPoint; Michael Hoppus; James Westfall

    2007-01-01

    Exploiting synergies afforded by a host of recently available national-scale data sets derived from interferometric synthetic aperture radar (InSAR) and passive optical remote sensing, this paper describes the development of a novel empirical approach for the provision of regional- to continental-scale estimates of vegetation canopy height. Supported by data from the...

  14. Exact Slater integrals

    International Nuclear Information System (INIS)

    Golden, L.B.

    1968-01-01

    In atomic structure calculations, one has to evaluate the Slater integrals. In the present program, the authors evaluate exactly the Slater integral when hydrogenic wave functions are used for the bound-state orbitals. When hydrogenic wave functions are used, the Slater integrals involve integrands which can be written in the form of a product of an exponential, exp(ax) and a known analytic polynomial function, f(x). By repeated partial integration such an integral can be expressed in terms of a finite series involving the exponential, the polynomial function and its derivatives. PL/1-FORMAC has a built-in subroutine that will analytically find the derivatives of any multinomial. Thus, the finite series and hence the Slater integral can be evaluated analytically. (Auth.)

  15. Introducing Empirical Exercises into Principles of Economics.

    Science.gov (United States)

    McGrath, Eileen L.; Tiemann, Thomas K.

    1985-01-01

    A rationale for requiring undergraduate students to become familiar with the empirical side of economics is presented, and seven exercises that can be used in an introductory course are provided. (Author/RM)

  16. Review essay: empires, ancient and modern.

    Science.gov (United States)

    Hall, John A

    2011-09-01

    This essay drews attention to two books on empires by historians which deserve the attention of sociologists. Bang's model of the workings of the Roman economy powerfully demonstrates the tributary nature of per-industrial tributary empires. Darwin's analysis concentrates on modern overseas empires, wholly different in character as they involved the transportation of consumption items for the many rather than luxury goods for the few. Darwin is especially good at describing the conditions of existence of late nineteenth century empires, noting that their demise was caused most of all by the failure of balance of power politics in Europe. Concluding thoughts are offered about the USA. © London School of Economics and Political Science 2011.

  17. Inland empire logistics GIS mapping project.

    Science.gov (United States)

    2009-01-01

    The Inland Empire has experienced exponential growth in the area of warehousing and distribution facilities within the last decade and it seems that it will continue way into the future. Where are these facilities located? How large are the facilitie...

  18. Teaching Empirical Software Engineering Using Expert Teams

    DEFF Research Database (Denmark)

    Kuhrmann, Marco

    2017-01-01

    Empirical software engineering aims at making software engineering claims measurable, i.e., to analyze and understand phenomena in software engineering and to evaluate software engineering approaches and solutions. Due to the involvement of humans and the multitude of fields for which software...... is crucial, software engineering is considered hard to teach. Yet, empirical software engineering increases this difficulty by adding the scientific method as extra dimension. In this paper, we present a Master-level course on empirical software engineering in which different empirical instruments...... an extra specific expertise that they offer as service to other teams, thus, fostering cross-team collaboration. The paper outlines the general course setup, topics addressed, and it provides initial lessons learned....

  19. Principles Involving Marketing Policies: An Empirical Assessment

    OpenAIRE

    JS Armstrong; Randall L. Schultz

    2005-01-01

    We examined nine marketing textbooks, published since 1927, to see if they contained useful marketing principles. Four doctoral students found 566 normative statements about pricing, product, place, or promotion in these texts. None of these stateinents were supported by empirical evidence. Four raters agreed on only twenty of these 566 statements as providing meaningful principles. Twenty marketing professors rated whether the twenty meaningful principles were correct, supported by empirical...

  20. Sources of Currency Crisis: An Empirical Analysis

    OpenAIRE

    Weber, Axel A.

    1997-01-01

    Two types of currency crisis models coexist in the literature: first generation models view speculative attacks as being caused by economic fundamentals which are inconsistent with a given parity. Second generation models claim self-fulfilling speculation as the main source of a currency crisis. Recent empirical research in international macroeconomics has attempted to distinguish between the sources of currency crises. This paper adds to this literature by proposing a new empirical approach ...