WorldWideScience

Sample records for emitter therapy methods

  1. Alpha-emitters for medical therapy workshop

    International Nuclear Information System (INIS)

    Feinendegen, L.E.; McClure, J.J.

    1996-01-01

    A workshop on ''Alpha-Emitters for Medical Therapy'' was held May 30-31, 1996 in Denver Colorado to identify research goals and potential clinical needs for applying alpha-particle emitters and to provide DOE with sufficient information for future planning. The workshop was attended by 36 participants representing radiooncology, nuclear medicine, immunotherapy, radiobiology, molecular biology, biochemistry, radiopharmaceutical chemistry, dosimetry, and physics. This report provides a summary of the key points and recommendations arrived at during the conference

  2. Alpha-emitters for medical therapy workshop

    Energy Technology Data Exchange (ETDEWEB)

    Feinendegen, L.E.; McClure, J.J.

    1996-12-31

    A workshop on ``Alpha-Emitters for Medical Therapy`` was held May 30-31, 1996 in Denver Colorado to identify research goals and potential clinical needs for applying alpha-particle emitters and to provide DOE with sufficient information for future planning. The workshop was attended by 36 participants representing radiooncology, nuclear medicine, immunotherapy, radiobiology, molecular biology, biochemistry, radiopharmaceutical chemistry, dosimetry, and physics. This report provides a summary of the key points and recommendations arrived at during the conference.

  3. Emittance measurements by variable quadrupole method

    International Nuclear Information System (INIS)

    Toprek, D.

    2005-01-01

    The beam emittance is a measure of both the beam size and beam divergence, we cannot directly measure its value. If the beam size is measured at different locations or under different focusing conditions such that different parts of the phase space ellipse will be probed by the beam size monitor, the beam emittance can be determined. An emittance measurement can be performed by different methods. Here we will consider the varying quadrupole setting method.

  4. Production of alpha emitters for therapy

    International Nuclear Information System (INIS)

    Vucina, J.; Orlic, M.; Lukic, D.

    2006-01-01

    The basis for the introduction of alpha emitters into nuclear medical practice are their radiobiological properties. High LET values and short ranges in biological tissues are advantageous in comparison with nowadays most often used beta emitters, primarily 90 Y and 131 I. Given are the most important criteria for the introduction of a given radionuclide in the routine use. Shown are the procedures for the production of the most important alpha emitters 211 At, 212 Bi and 213 Bi. (author)

  5. Complementary methods of transverse emittance measurement

    Energy Technology Data Exchange (ETDEWEB)

    Zagel, James; Hu, Martin; Jansson, Andreas; Thurman-Keup, Randy; Yan, Ming-Jen; /Fermilab

    2008-05-01

    Several complementary transverse emittance monitors have been developed and used at the Fermilab accelerator complex. These include Ionization profile Monitors (IPM), Flying Wires, Schottky detectors and a Synchrotron Light Monitor (Synchlite). Mechanical scrapers have also been used for calibration purposes. This paper describes the various measurement devices by examining their basic features, calibration requirements, systematic uncertainties, and applications to collider operation. A comparison of results from different kinds of measurements is also presented.

  6. Cancer therapy with alpha-emitters labeled peptides.

    Science.gov (United States)

    Dadachova, Ekaterina

    2010-05-01

    Actively targeted alpha-particles offer specific tumor cell killing action with less collateral damage to surrounding normal tissues than beta-emitters. During the last decade, radiolabeled peptides that bind to different receptors on the tumors have been investigated as potential therapeutic agents both in the preclinical and clinical settings. Advantages of radiolabeled peptides over antibodies include relatively straightforward chemical synthesis, versatility, easier radiolabeling, rapid clearance from the circulation, faster penetration and more uniform distribution into tissues, and less immunogenicity. Rapid internalization of the radiolabeled peptides with equally rapid re-expression of the cell surface target is a highly desirable property that enhances the total delivery of these radionuclides into malignant sites. Peptides, such as octreotide, alpha-melanocyte-stimulating hormone analogues, arginine-glycine-aspartic acid-containing peptides, bombesin derivatives, and others may all be feasible for use with alpha-emitters. The on-going preclinical work has primarily concentrated on octreotide and octreotate analogues labeled with Bismuth-213 and Astatine-211. In addition, alpha-melanocyte-stimulating hormone analogue has been labeled with Lead-212/Bismuth-212 in vivo generator and demonstrated the encouraging therapeutic efficacy in treatment of experimental melanoma. Obstacles that continue to obstruct widespread acceptance of alpha-emitter-labeled peptides are primarily the supply of these radionuclides and concerns about potential kidney toxicity. New sources and methods for production of these medically valuable radionuclides and better understanding of mechanisms related to the peptide renal uptake and clearance should speed up the introduction of alpha-emitter-labeled peptides into the clinic. Copyright 2010 Elsevier Inc. All rights reserved.

  7. Calculating emittance for Gaussian and Non-Gaussian distributions by the method of correlations for slits

    International Nuclear Information System (INIS)

    Tan, Cheng-Yang; Fermilab

    2006-01-01

    One common way for measuring the emittance of an electron beam is with the slits method. The usual approach for analyzing the data is to calculate an emittance that is a subset of the parent emittance. This paper shows an alternative way by using the method of correlations which ties the parameters derived from the beamlets to the actual parameters of the parent emittance. For parent distributions that are Gaussian, this method yields exact results. For non-Gaussian beam distributions, this method yields an effective emittance that can serve as a yardstick for emittance comparisons

  8. Monitoring method of short-emitters

    International Nuclear Information System (INIS)

    Gasanov, R.A.

    2013-01-01

    Radioprospecting is the initial stage of radioelectronic warfare and its main purpose is destination of the radio signal, determination of its parameters, to detect the content of broadcasts, as well as detection the locating of devices emitting radio signal. In all cases, the probability of signal interception is basically determined by the specified parameters of signals intelligence. The increase in speed is accompanied by a decrease in resolution and vice versa. This paper discusses the method of monitoring the short-term radio emissions, which adapts to the electromagnetic environment

  9. A new concept for the modeling of the positron emitter production for the particle therapy

    International Nuclear Information System (INIS)

    Priegnitz, Marlen

    2012-01-01

    One of the three main tumour treatment forms is radiation therapy. Here, the application of ion beams, in particular protons and carbon ions, is of growing importance. This high precision therapy requires a consequent monitoring of the dose delivery since the induced dose deposition is very sensitive to density changes in the irradiated tissue. Up to now, positron emission tomography (PET) is the only in vivo method in clinical use for monitoring the dose deposition in ion beam therapy. It allows for the verification of the particle range as well as the position of the irradiation field. The distribution of activity measured by means of PET cannot be compared directly to the planned dose distribution. Thus, a calculation of the expected activity distribution is required which then can be compared to the measurement. Simulation of the expected activity distribution requires the exact knowledge of various cross sections. Only a few of them have been measured in the required energy range so far. Therefore, in Monte Carlo simulations often intrinsic nuclear models or semi-empirical parametrization are used which often exhibit insufficient accuray. Among experts the question on the optimum ion species for tumour therapy is still open. Especially lithium ions exhibit a great potential due to their favourable physical and radiobiological properties. Also for these ions a PET monitoring is highly desirable. The presented work shows the feasibility of range verification by means of PET for lithium irradiation. Furthermore, a concept for modeling positron emitter distributions without the knowledge of cross sections is developed. This prediction is based on depth-dependent positron emitter yields measured in reference materials (water, graphite and polyethylene). With these data the positron emitter distribution in any material of known stoichiometry can be calculated by means of an appropriate linear combination. The feasibility of the yield concept is shown for lithium and

  10. Biologic data, models, and dosimetric methods for internal emitters

    International Nuclear Information System (INIS)

    Weber, D.A.

    1990-01-01

    The absorbed radiation dose from internal emitters has been and will remain a pivotal factor in assessing risk and therapeutic utility in selecting radiopharmaceuticals for diagnosis and treatment. Although direct measurements of absorbed dose and dose distributions in vivo have been and will continue to be made in limited situations, the measurement of the biodistribution and clearance of radiopharmaceuticals in human subjects and the use of this data is likely to remain the primary means to approach the calculation and estimation of absorbed dose from internal emitters over the next decade. Since several approximations are used in these schema to calculate dose, attention must be given to inspecting and improving the application of this dosimetric method as better techniques are developed to assay body activity and as more experience is gained in applying these schema to calculating absorbed dose. Discussion of the need for considering small scale dosimetry to calculate absorbed dose at the cellular level will be presented in this paper. Other topics include dose estimates for internal emitters, biologic data mathematical models and dosimetric methods employed. 44 refs

  11. A combined emitter threat assessment method based on ICW-RCM

    Science.gov (United States)

    Zhang, Ying; Wang, Hongwei; Guo, Xiaotao; Wang, Yubing

    2017-08-01

    Considering that the tradition al emitter threat assessment methods are difficult to intuitively reflect the degree of target threaten and the deficiency of real-time and complexity, on the basis of radar chart method(RCM), an algorithm of emitter combined threat assessment based on ICW-RCM (improved combination weighting method, ICW) is proposed. The coarse sorting is integrated with fine sorting in emitter combined threat assessment, sequencing the emitter threat level roughly accordance to radar operation mode, and reducing task priority of the low-threat emitter; On the basis of ICW-RCM, sequencing the same radar operation mode emitter roughly, finally, obtain the results of emitter threat assessment through coarse and fine sorting. Simulation analyses show the correctness and effectiveness of this algorithm. Comparing with classical method of emitter threat assessment based on CW-RCM, the algorithm is visual in image and can work quickly with lower complexity.

  12. Immuno-vectorization of radioelements emitters of alpha particles: a new therapy in cancerology

    International Nuclear Information System (INIS)

    Bourgeois, M.

    2007-05-01

    The radio-immunotherapy is an anti cancerous therapy which consists in vectorising with immuno-specific agents very radio toxic radioelements on tumors or in their environment to destroy them. The first part of this report presents the different characteristics of antibodies as well as their means of production under monoclonal shapes specifically steered against a tumoral antigen of interest. The second part of this report replaces the importance of the immunological vectors in the context of the nuclear medicine. It is notably described that the different methods which allow to radio-label the vector, as well as the different ways of optimization which were envisaged to improve the targeting of radioelements on a tumor. These different developments allow to define the potential place of the alpha radio-immunotherapy in treatments and so re-place the interest of the experimental part. If the radio-immunotherapy, using beta emitters isotopes as the 131 iodine or the 90 yttrium, is today current in anti cancerous therapy, it finds limits because of the disintegration characteristics of the isotopes it uses. Indeed, compared with alpha particles, the beta particles deposit less energy by unit of length in the crossed material.The experimental part of this report aims at studying the feasibility of the coupling between an immunological vector and an alpha emitter isotope.The different tests led on the bismuth 213, the bismuth 212, the lead 212 and the astatine 211 demonstrated that the fixation of these radionuclides was possible. This research theme is strengthened by the construction in Nantes of a cyclotron with high energy ( A.R.R.O.N.A.X.) and the optimization of the obtained promising results should allow a therapeutic use in oncology of the alpha radio-immunotherapy. (N.C.)

  13. Radial arrays of nano-electrospray ionization emitters and methods of forming electrosprays

    Science.gov (United States)

    Kelly, Ryan T [West Richland, WA; Tang, Keqi [Richland, WA; Smith, Richard D [Richland, WA

    2010-10-19

    Electrospray ionization emitter arrays, as well as methods for forming electrosprays, are described. The arrays are characterized by a radial configuration of three or more nano-electrospray ionization emitters without an extractor electrode. The methods are characterized by distributing fluid flow of the liquid sample among three or more nano-electrospray ionization emitters, forming an electrospray at outlets of the emitters without utilizing an extractor electrode, and directing the electrosprays into an entrance to a mass spectrometry device. Each of the nano-electrospray ionization emitters can have a discrete channel for fluid flow. The nano-electrospray ionization emitters are circularly arranged such that each is shielded substantially equally from an electrospray-inducing electric field.

  14. Dependence of simulated positron emitter yields in ion beam cancer therapy on modeling nuclear fragmentation

    DEFF Research Database (Denmark)

    Lühr, Armin; Priegnitz, Marlen; Fiedler, Fine

    2014-01-01

    In ion beam cancer therapy, range verification in patients using positron emission tomography (PET) requires the comparison of measured with simulated positron emitter yields. We found that (1) changes in modeling nuclear interactions strongly affected the positron emitter yields and that (2) Monte...... Carlo simulations with SHIELD-HIT10A reasonably matched the most abundant PET isotopes 11C and 15O. We observed an ion-energy (i.e., depth) dependence of the agreement between SHIELD-HIT10A and measurement. Improved modeling requires more accurate measurements of cross-section values....

  15. Standard Test Method for Normal Spectral Emittance at Elevated Temperatures

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    1972-01-01

    1.1 This test method describes a highly accurate technique for measuring the normal spectral emittance of electrically conducting materials or materials with electrically conducting substrates, in the temperature range from 600 to 1400 K, and at wavelengths from 1 to 35 μm. 1.2 The test method requires expensive equipment and rather elaborate precautions, but produces data that are accurate to within a few percent. It is suitable for research laboratories where the highest precision and accuracy are desired, but is not recommended for routine production or acceptance testing. However, because of its high accuracy this test method can be used as a referee method to be applied to production and acceptance testing in cases of dispute. 1.3 The values stated in SI units are to be regarded as the standard. The values in parentheses are for information only. 1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this stan...

  16. Measured emittance dependence on injection method in laser plasma accelerators

    Science.gov (United States)

    Barber, Samuel; van Tilborg, Jeroen; Schroeder, Carl; Lehe, Remi; Tsai, Hai-En; Swanson, Kelly; Steinke, Sven; Nakamura, Kei; Geddes, Cameron; Benedetti, Carlo; Esarey, Eric; Leemans, Wim

    2017-10-01

    The success of many laser plasma accelerator (LPA) based applications relies on the ability to produce electron beams with excellent 6D brightness, where brightness is defined as the ratio of charge to the product of the three normalized emittances. As such, parametric studies of the emittance of LPA generated electron beams are essential. Profiting from a stable and tunable LPA setup, combined with a carefully designed single-shot transverse emittance diagnostic, we present a direct comparison of charge dependent emittance measurements of electron beams generated by two different injection mechanisms: ionization injection and shock induced density down-ramp injection. Notably, the measurements reveal that ionization injection results in significantly higher emittance. With the down-ramp injection configuration, emittances less than 1 micron at spectral charge densities up to 2 pC/MeV were measured. This work was supported by the U.S. DOE under Contract No. DE-AC02-05CH11231, by the NSF under Grant No. PHY-1415596, by the U.S. DOE NNSA, DNN R&D (NA22), and by the Gordon and Betty Moore Foundation under Grant ID GBMF4898.

  17. Simple emittance measurement of negative hydrogen ion beam using pepper-pot method

    International Nuclear Information System (INIS)

    Hamabe, M.; Tsumori, K.; Takeiri, Y.; Kaneko, O.; Asano, E.; Kawamoto, T.; Kuroda, T.; Guharay, S.K.

    1997-01-01

    A simple apparatus for emittance measurement using pepper-pot method is developed. The pepper-pot patterns are directly exposed and recorded on a Kapton foil. Using this apparatus, emittance was measured in the case of the negative hydrogen (H - ) beam from the large negative ion source, which is the 1/3 scaled test device for the negative-ion-based neutral beam injection (N-NBI) on the Large Helical Device (LHD). As the consequence of the first trial, the 95% normalized emittance value is measured as 0.59 mm mrad. (author)

  18. Simple emittance measurement of negative hydrogen ion beam using pepper-pot method

    Energy Technology Data Exchange (ETDEWEB)

    Hamabe, M.; Tsumori, K.; Takeiri, Y.; Kaneko, O.; Asano, E.; Kawamoto, T.; Kuroda, T. [National Inst. for Fusion Science, Nagoya (Japan); Guharay, S.K.

    1997-02-01

    A simple apparatus for emittance measurement using pepper-pot method is developed. The pepper-pot patterns are directly exposed and recorded on a Kapton foil. Using this apparatus, emittance was measured in the case of the negative hydrogen (H{sup -}) beam from the large negative ion source, which is the 1/3 scaled test device for the negative-ion-based neutral beam injection (N-NBI) on the Large Helical Device (LHD). As the consequence of the first trial, the 95% normalized emittance value is measured as 0.59 mm mrad. (author)

  19. An experimental method for making spectral emittance and surface temperature measurements of opaque surfaces

    International Nuclear Information System (INIS)

    Moore, Travis J.; Jones, Matthew R.; Tree, Dale R.; Daniel Maynes, R.; Baxter, Larry L.

    2011-01-01

    An experimental procedure has been developed to make spectral emittance and temperature measurements. The spectral emittance of an object is calculated using measurements of the spectral emissive power and of the surface temperature of the object obtained using a Fourier transform infrared (FTIR) spectrometer. A calibration procedure is described in detail which accounts for the temperature dependence of the detector. The methods used to extract the spectral emissive power and surface temperature from measured infrared spectra were validated using a blackbody radiator at known temperatures. The average error in the measured spectral emittance was 2.1% and the average difference between the temperature inferred from the recorded spectra and the temperature indicated on the blackbody radiator was 1.2%. The method was used to measure the spectral emittance of oxidized copper at various temperatures.

  20. Comparison of two methods for measuring the emittance of a beam

    International Nuclear Information System (INIS)

    Parain, J.

    Two methods of measuring beam emittance were analyzed. The three-distance method is based on measurement of the dimensions of the beam at three points, while the three-slope method uses beam dimension measurements under three focusing conditions. Allowing for the errors in measuring the dimensions of the beam, the two methods are of equal accuracy. The three-distance method requires three detectors, but it has the advantage of making it possible to measure the emittance on a single cycle of the accelerator, and can therefore be used to perform control measurements on each cycle. (auth)

  1. Method validation to determine total alpha beta emitters in water samples using LSC

    International Nuclear Information System (INIS)

    Al-Masri, M. S.; Nashawati, A.; Al-akel, B.; Saaid, S.

    2006-06-01

    In this work a method was validated to determine gross alpha and beta emitters in water samples using liquid scintillation counter. 200 ml of water from each sample were evaporated to 20 ml and 8 ml of them were mixed with 12 ml of the suitable cocktail to be measured by liquid scintillation counter Wallac Winspectral 1414. The lower detection limit by this method (LDL) was 0.33 DPM for total alpha emitters and 1.3 DPM for total beta emitters. and the reproducibility limit was (± 2.32 DPM) and (±1.41 DPM) for total alpha and beta emitters respectively, and the repeatability limit was (±2.19 DPM) and (±1.11 DPM) for total alpha and beta emitters respectively. The method is easy and fast because of the simple preparation steps and the large number of samples that can be measured at the same time. In addition, many real samples and standard samples were analyzed by the method and showed accurate results so it was concluded that the method can be used with various water samples. (author)

  2. Asymmetrical field emitter

    Science.gov (United States)

    Fleming, J.G.; Smith, B.K.

    1995-10-10

    A method is disclosed for providing a field emitter with an asymmetrical emitter structure having a very sharp tip in close proximity to its gate. One preferred embodiment of the present invention includes an asymmetrical emitter and a gate. The emitter having a tip and a side is coupled to a substrate. The gate is connected to a step in the substrate. The step has a top surface and a side wall that is substantially parallel to the side of the emitter. The tip of the emitter is in close proximity to the gate. The emitter is at an emitter potential, and the gate is at a gate potential such that with the two potentials at appropriate values, electrons are emitted from the emitter. In one embodiment, the gate is separated from the emitter by an oxide layer, and the emitter is etched anisotropically to form its tip and its asymmetrical structure. 17 figs.

  3. A fabrication method for field emitter array of carbon nanotubes with improved carbon nanotube rooting

    Energy Technology Data Exchange (ETDEWEB)

    Chouhan, V., E-mail: vchouhan@post.kek.jp [School of High Energy Accelerator, The Graduate University for Advanced Studies, Tsukuba 305-0801 (Japan); Noguchi, T. [High Energy Accelerator Research Organization (KEK), Tsukuba 305-0801 (Japan); Kato, S. [School of High Energy Accelerator, The Graduate University for Advanced Studies, Tsukuba 305-0801 (Japan); High Energy Accelerator Research Organization (KEK), Tsukuba 305-0801 (Japan)

    2015-11-30

    We have developed a technique for fabrication of a field emitter array (FEA) of carbon nanotubes (CNTs) to obtain a high emission current along with a high current density. The FEA was prepared with many small equidistant circular emitters of randomly oriented multiwall carbon nanotubes. The fabrication of a FEA substrate followed with deposition of titanium nitride (TiN) film on a tantalum (Ta) substrate and circular titanium (Ti) islands on the TiN coated Ta substrate in a DC magnetron sputtering coater. CNTs were dispersed on the substrate and rooted into the circular Ti islands at a high temperature to prepare an array of circular emitters of CNTs. The TiN film was applied on a Ta substrate to make a reaction barrier between the Ta substrate and CNTs in order to root CNTs only into the Ti islands without a reaction with the Ta substrate at the high temperature. A high emission current of 31.7 mA with an effective current density of 34.5 A/cm{sup 2} was drawn at 6.5 V/μm from a FEA having 130 circular emitters in a diameter of 50 μm and with a pitch of 200 μm. The high emission current was ascribed to the good quality rooting of CNTs into the Ti islands and an edge effect, in which a high emission current was expected from the peripheries of the circular emitters. - Highlights: • We developed a method to fabricate a field emitter array of carbon nanotubes (CNTs). • CNT rooting into array of titanium islands was improved at a high temperature. • Titanium nitride film was used to stop reaction between CNT and tantalum substrate. • Strong edge effect was achieved from an array of small circular emitters of CNTs. • The good quality CNT rooting and the edge effect enhanced an emission current.

  4. Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours

    DEFF Research Database (Denmark)

    Thisgaard, Helge; Elema, Dennis Ringkjøbing; Jensen, Mikael

    2011-01-01

    Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of the gr...

  5. Therapy with high LET Radioisotopes: Can sufficient levels of attractive Auger and alpha emitters be produced to make their use practical?

    International Nuclear Information System (INIS)

    Knapp, F.F. Jr.; Mirzadeh, S.; Stabin, M.; Brill, A.B.

    2005-01-01

    Because of localized energy deposition within a very small volume, cellular targeted therapy with high linear energy transfer (LET) Auger-electron and alpha-particle emitting radioisotopes is of great interest. While the energy deposition from alpha particles usually encompasses several cell diameters, the dose from Auger electrons is confined to a single cell. Two major challenges for broader use of Alpha and Auger emitters are the efficient and cost effective routine production of sufficient levels of these radioisotopes, and the availability of targeting molecules to which the radioisotopes can be attached for cellular delivery of sufficient levels of activity for effective therapy. Examples of several Alpha-and Auger-emitting radioisotopes of current interest are presented. Alpha- and Auger electron-emitting radioisotopes can be produced in accelerators (A) and nuclear reactors (R), and several alpha emitter congeners (i.e. thorium-229) can be obtained from uranium decay products. The challenge for reactor production, is the availability and exploitation of methods - other then the usual radiative (n,γ) production route which will provide no-carrier-added (nca) or the high specific activity radioisotopes of interest. The submitted manuscript has been authored by a contractor of the U.S. Government under contract DE-AC05-00OR22725. Accordingly, the U.S. Government retains a nonexclusive, royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for U.S. Government purposes High LET radioisotopes of current interest which are in the initial stages of development and/or which demonstrate practical use in clinical trials include several alpha-emitters, in particular bismuth-213 - and also the actinium-225 parent - astatine-211 and bismuth-212. Extensive experimental studies have been reported with Auger iododeoxyuridine (IdUR) radiolabeled with the iodine-125 emitter-labeled. However, development of production

  6. Alpha emitters activity measurement using the defined solid angle method

    International Nuclear Information System (INIS)

    Blanchis, P.

    1983-01-01

    The defined solid angle counting method can reach a very high accuracy, specially for heavy ions as alpha particles emitted by a radioactive source. The activity measurement of such sources with a relative uncertainty of the order of 0.01% is investigated. Such an accuracy is available only under suitable conditions: the radiation emitted by the source must be isotropic and all the particles emitted in the effective solid angle must be detected. The efficiency detection value must be equal to unity and phenomena such as absorption or scattering must be null. It is shown that corrections often become necessary. All parameters which can influence the measurements are studied [fr

  7. Preliminary studies for the determination of alpha emitters using the gross alpha coprecipitation methods

    International Nuclear Information System (INIS)

    Suarez-Navarro, J. A.; Pujol, L.; Suarez, J. A.; Pablo, M. A. de

    2003-01-01

    The radiological quality of drinking water in Spain is regulated by Nuclear Security Guideline No, 7.7 (Rev.1) of the Nuclear Security Council (NSC). this guideline establishes the protocol to follow when the radiological level exceeds 0,1 Bq.l''1. When this level is passed, the responsible alpha emitter must be identified; ''210 Po, ''226Ra, ''230Th, ''239Pu, ''224Ra, ''234 U and ''138 U. Activity due to these isotopes is usually determined using alpha spectrometry with semiconductor detectors. This method allows the activity of the alpha emitters to be determined with a good sensitivity. however, it requires long radiochemical isolations and long counting times, so the method is not suitable for rough estimate radiological analysis. In this preliminary work, we present the conditioning of the sample-precipitate that is essential for further radiochemical isolations. (Author) 9 refs

  8. Method of measuring the current density distribution and emittance of pulsed electron beams

    International Nuclear Information System (INIS)

    Schilling, H.B.

    1979-07-01

    This method of current density measurement employs an array of many Faraday cups, each cup being terminated by an integrating capacitor. The voltages of the capacitors are subsequently displayed on a scope, thus giving the complete current density distribution with one shot. In the case of emittance measurements, a moveable small-diameter aperture is inserted at some distance in front of the cup array. Typical results with a two-cathode, two-energy electron source are presented. (orig.)

  9. A new concept for the modeling of the positron emitter production for the particle therapy; Ein neues Konzept zur Modellierung der Positronenemitter-Produktion bei der Partikeltherapie

    Energy Technology Data Exchange (ETDEWEB)

    Priegnitz, Marlen

    2012-07-01

    One of the three main tumour treatment forms is radiation therapy. Here, the application of ion beams, in particular protons and carbon ions, is of growing importance. This high precision therapy requires a consequent monitoring of the dose delivery since the induced dose deposition is very sensitive to density changes in the irradiated tissue. Up to now, positron emission tomography (PET) is the only in vivo method in clinical use for monitoring the dose deposition in ion beam therapy. It allows for the verification of the particle range as well as the position of the irradiation field. The distribution of activity measured by means of PET cannot be compared directly to the planned dose distribution. Thus, a calculation of the expected activity distribution is required which then can be compared to the measurement. Simulation of the expected activity distribution requires the exact knowledge of various cross sections. Only a few of them have been measured in the required energy range so far. Therefore, in Monte Carlo simulations often intrinsic nuclear models or semi-empirical parametrization are used which often exhibit insufficient accuray. Among experts the question on the optimum ion species for tumour therapy is still open. Especially lithium ions exhibit a great potential due to their favourable physical and radiobiological properties. Also for these ions a PET monitoring is highly desirable. The presented work shows the feasibility of range verification by means of PET for lithium irradiation. Furthermore, a concept for modeling positron emitter distributions without the knowledge of cross sections is developed. This prediction is based on depth-dependent positron emitter yields measured in reference materials (water, graphite and polyethylene). With these data the positron emitter distribution in any material of known stoichiometry can be calculated by means of an appropriate linear combination. The feasibility of the yield concept is shown for lithium and

  10. Alpha particle emitters in cancer therapy: establishing the rationale and overcoming the difficulties

    International Nuclear Information System (INIS)

    Sgouros, G.

    1996-01-01

    rapidly accessible disease. Alpha particles will be most useful in situations in which targeting is rapid, killing of isolated single-cells is important and access to normal tissue is minimized. The latter may be achieved by intracavitary administration or by labeling an agent that does not reach normal tissues before the radionuclide has decayed below an acceptable level. Although alpha-particle emitters have shown promise in animal models, they have not been examined in patients. The decay of 212 Bi is accompanied by emission of high energy (2.6 MeV) photons which are difficult to shield; 211 At is cyclotron produced and of limited availability. The initial obstacles to the use of alpha-particle emitters for therapy are availability, handling and radiochemistry. These are being overcome with the introduction of new radionuclides and better radiochemistry. Bismuth-213, for example, is similar to Bi-212 in its alpha particle emissions but does not emit the highly energetic photon seen with Bi-212. Once the initial, logistical obstacles are surmounted, the dosimetry and normal tissue toxicity must be investigated

  11. Emitter signal separation method based on multi-level digital channelization

    Science.gov (United States)

    Han, Xun; Ping, Yifan; Wang, Sujun; Feng, Ying; Kuang, Yin; Yang, Xinquan

    2018-02-01

    To solve the problem of emitter separation under complex electromagnetic environment, a signal separation method based on multi-level digital channelization is proposed in this paper. A two-level structure which can divide signal into different channel is designed first, after that, the peaks of different channels are tracked using the track filter and the coincident signals in time domain are separated in time-frequency domain. Finally, the time domain waveforms of different signals are acquired by reverse transformation. The validness of the proposed method is proved by experiment.

  12. Standard Test Method for Normal Spectral Emittance at Elevated Temperatures of Nonconducting Specimens

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    1971-01-01

    1.1 This test method describes an accurate technique for measuring the normal spectral emittance of electrically nonconducting materials in the temperature range from 1000 to 1800 K, and at wavelengths from 1 to 35 μm. It is particularly suitable for measuring the normal spectral emittance of materials such as ceramic oxides, which have relatively low thermal conductivity and are translucent to appreciable depths (several millimetres) below the surface, but which become essentially opaque at thicknesses of 10 mm or less. 1.2 This test method requires expensive equipment and rather elaborate precautions, but produces data that are accurate to within a few percent. It is particularly suitable for research laboratories, where the highest precision and accuracy are desired, and is not recommended for routine production or acceptance testing. Because of its high accuracy, this test method may be used as a reference method to be applied to production and acceptance testing in case of dispute. 1.3 This test metho...

  13. Characteristics of infrared thermometers manufactured in Japan and calibration methods for sky radiant emittance

    International Nuclear Information System (INIS)

    Wang, X.; Horiguchi, I.; Machimura, T.

    1993-01-01

    Infrared thermometers to measure surface temperature have been increasingly adopted in recent years. The characteristics of the IR thermometer, however, are not well known.IR thermometers manufactured in Japan systematically adjust for ambient radiation based on the internal temperature of the thermometer. If, therefore, there is a large difference between the internal temperature of the IR thermometer and the apparent temperature associated with the surrounding radiation, a large error will be induced into the measured surface temperature.The purpose of our research was to determine the characteristics and measurement errors of IR thermometers. Experiments were performed with regard to the following items: (1) Measurement errors related to the internal temperature of the IR thermometer. (2) Linearity of the output signal of the IR thermometer. (3) Response of the output signal to changes in the emissivity setting. (4) Effect of sky radiant emittance on the measured surface temperature. (5) Calibration method for the terrestrial surface.The following is a summary of the results: Measurement error is affected by the internal temperature of the IR thermometer. Measurement accuracy is improved with a controlled internal temperature of 20-30°C. The measurement error becomes larger at emissivity settings under 0.7.The measurement error outdoors was not proportional to the downward longwave radiation, but to the sky radiant temperature measured by the IR thermometer. Calibration for sky radiant emittance was improved by using the difference between sky radiant temperature and air temperature.When the surface temperature measured by the infrared thermometer is plotted against the surface temperature measured by thermocouple, the sky radiant emittance error is obtained from the Y intercept. Additionally, the difference between true temperature and output of the IR thermometer for a reference plate was compared to that obtained for vegetation, and the RMS obtained was

  14. A Time-Space Domain Information Fusion Method for Specific Emitter Identification Based on Dempster-Shafer Evidence Theory.

    Science.gov (United States)

    Jiang, Wen; Cao, Ying; Yang, Lin; He, Zichang

    2017-08-28

    Specific emitter identification plays an important role in contemporary military affairs. However, most of the existing specific emitter identification methods haven't taken into account the processing of uncertain information. Therefore, this paper proposes a time-space domain information fusion method based on Dempster-Shafer evidence theory, which has the ability to deal with uncertain information in the process of specific emitter identification. In this paper, radars will generate a group of evidence respectively based on the information they obtained, and our main task is to fuse the multiple groups of evidence to get a reasonable result. Within the framework of recursive centralized fusion model, the proposed method incorporates a correlation coefficient, which measures the relevance between evidence and a quantum mechanical approach, which is based on the parameters of radar itself. The simulation results of an illustrative example demonstrate that the proposed method can effectively deal with uncertain information and get a reasonable recognition result.

  15. Methods of measuring of the ion beam transversal emittance in the injection channel of the cyclotron DC-72

    CERN Document Server

    Kazarinov, N; Kalagin, I V; Kazacha, V I

    2002-01-01

    The methods of measuring of the transversal emittance of ion beams in the cyclotron DC-72 injection channel with the help of the 'pepper-pot' and gradient means are discussed in this work. Two ways for the reconstruction of the ion beam transversal emittance are proposed for the 'pepper-pot' method. The first one can be used for beams having the uniform distribution of particles in the phase space. At that the values of the Twiss matrix and the full beam emittance are reconstructed according to the measurement results with the help of the phase ellipse fitting by the least-squares method. The corresponding FORTRAN code was created. On simulation the beam emittance was reconstructed with accuracy of 5%. The second method of the beam emittance reconstruction can be used in the common case at the arbitrary particle distribution in the phase space. It is based on calculation of the mean-square parameters of the beam according to the measurement results in the plane of the 'pepper-pot' mask. The mean-square emitta...

  16. Production and dosimetric aspects of the potent Auger emitter 58mCo for targeted radionuclide therapy of small tumors

    International Nuclear Information System (INIS)

    Thisgaard, H.; Elema, D.R.; Jensen, M.

    2011-01-01

    Purpose: Based on theoretical calculations, the Auger emitter 58m Co has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58g Co is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58m Co. The impact of 58g Co as a β + - and γ-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58m Co and 58g Co using a low-energy cyclotron. Also, the cellular S-values for 58m Co have been calculated and are presented here for the first time. Methods: 58m Co was produced via the 58 Fe(p,n) 58m Co nuclear reaction on highly enriched 58 Fe metal. In addition, radiochemical separations of produced radio-cobalt from nat Fe target material were performed. The theoretical subcellular dosimetry calculations for 58m Co and 58g Co were performed using the MIRD formalism, and the impact of the increasing ground state impurity on the tumor-to-normal-tissue dose ratios (TND) per disintegration as a function of time after end of bombardment (EOB) was calculated. Results: 192 ± 8 MBq of 58m Co was produced in the irradiation corresponding to a production yield of 10.7 MBq/μAh. The activity of 58g Co was measured to be 0.85% ± 0.04% of the produced 58m Co activity at EOB. The radio-cobalt yields in the rapid separations were measured to be >97% with no detectable iron contaminations in the cobalt fractions. Due to the unavoidable coproduction and ingrowth of the long-lived ground state 58g Co, the TND and the potency of the 58m Co decrease with time after EOB. If a future treatment with a 58m Co labeled compound is not initiated before, e.g., 21 h after EOB, the resulting TND will be approximately 50% of the TND of 'pure' 58m Co as a result of the increased normal tissue dose from

  17. Two-nucleon emitters within a pseudostate method: The case of 6Be and 16Be

    Science.gov (United States)

    Casal, J.

    2018-03-01

    Background: Since the first experimental observation, two-nucleon radioactivity has gained renewed attention since the early 2000s. The 6Be system is the lightest two-proton ground-state emitter, while 16Be was recently proposed to be the first two-neutron ground-state emitter ever observed. A proper understanding of their properties and decay modes requires a reasonable description of the three-body continuum. Purpose: Study the ground-state properties of 6Be and 16Be within a general three-body model and investigate their nucleon-nucleon correlations in the continuum. Method: The pseudostate (PS) method in hyperspherical coordinates, using the analytical transformed harmonic oscillator (THO) basis for three-body systems, is used to construct the 6Be and 16Be ground-state wave functions. These resonances are approximated as a stable PS around the known two-nucleon separation energy. Effective core-N potentials, constrained by the available experimental information on the binary subsystems 5Li and 15Be, are employed in the calculations. Results: The ground state of 16Be is found to present a strong dineutron configuration, with the valence neutrons occupying mostly an l =2 state relative to the core. The results are consistent with previous R -matrix calculations for the actual continuum. The case of 6Be shows a clear symmetry with respect to its mirror partner, the two-neutron halo 6He: The diproton configuration is dominant, and the valence protons occupy an l =1 orbit. Conclusions: The PS method is found to be a suitable tool in describing the properties of unbound core+N +N ground states. For both 16Be and 6Be, the results are consistent with previous theoretical studies and confirm the dominant dinucleon configuration. This favors the picture of a correlated two-nucleon emission.

  18. Application of the 4 pigammaMethod to the Absolute Standardization of Radioactive Sources of Positron Emitters

    International Nuclear Information System (INIS)

    Peyres Medina, V.; Garcia-Torano Martinez, E.; Roteta Ibarra, M.

    2006-01-01

    We discuss the application of the method known as 4 p i g amma c ounting t o the standardization of positron emitters. Monte Carlo simulations are used to calculate the detection efficiency of positrons emitted by the nuclides 22Na and 18F. Two experimental setups are used, both based on a NaI(Tl) well detector. The results of the standardizations are in good agreement with those obtained by other methods. It is shown that the 4 p i g amma m ethod can be successfully used for the absolute standardization of sources of positron emitters. (Author) 23 refs

  19. Rapid method of identification of β-ray emitters and of β-radioactive impurity dosage (1961)

    International Nuclear Information System (INIS)

    Le Gallic, Y.; Legrand, J.; Grinberg, B.

    1961-01-01

    We describe a simple method of radioactive analysis, which allows an accurate determination of maximal energies of β-emitters, and detection and titration of radioactive impurities in radionuclides as well. The method described, which uses a plastic scintillator, is based on the fact that the curve obtained by plotting the number of pulses measured against the threshold is a straight line, in the case of pure β-emitters. We then derive a simple relation between the data of this straight line and the maximal energy of the β-spectrum of the radionuclide under consideration. (authors) [fr

  20. Modeling the effects of repeated systemic administrations of small activity amounts In radionuclide therapy with beta emitters

    International Nuclear Information System (INIS)

    Calderon, Carlos; Gonzalez, Joaquin; Cepero, Janet; Colom, Camila; Rodriguez, Juan C.

    2008-01-01

    Full text: Good results for radionuclide therapy treatments where repeated short time spaced systemic injection of small activity amounts are given have been reported. Bone marrow and kidneys are usually considered as dose-limiting organs in radionuclide therapy. The treatments in radionuclide therapy with repeated administration could be optimized if irradiation effects in those one might be estimated. Xeno-grafted mice is the often biological model used during the evaluation of candidates for radionuclide therapy. A mathematical model of tumor cell kinetics was combined with another one reported for marrow cell kinetics which allows the calculation of marrow cell survival and proliferation in response to different irradiation schemes. Radionuclide therapy treatment with repeated administrations with radiopharmaceuticals labeled with beta emitters were simulated. The effects on fast-growing and slow-growing tumors were evaluated, as well as radiosensitive and radioresistant tumors. For more realistic estimation of absorbed dose in mice organs the cross-irradiation due to high energy beta particles was included into the MIRD's formula. Tumor and kidneys responses to the irradiation were estimated on the linear-quadratic model framework which was adapted for a multi-exponential dose rate function describing radionuclide therapy treatments with repeated administrations. Published values for murine tumors kinetics, marrows cellular turnover rates and radiosensitivities were used during the calculations. Iso-effective schemes were also determined varying the interval between fractions and the number of administration. For a given tolerated level of thrombocytopenia and absorbed dose in kidneys an optimal regime of radionuclide therapy with repeated administration could be found. The mathematical model presented here allows the prediction of the nadir and duration of thrombocytopenia, the effects on kidneys and the tumor cell response to various treatment schemes

  1. Emittance preservation

    Energy Technology Data Exchange (ETDEWEB)

    Kain, V; Arduini, G; Goddard, B; Holzer, B J; Jowett, J M; Meddahi, M; Mertens, T; Roncarolo, F; Schaumann, M; Versteegen, R; Wenninger, J [European Organization for Nuclear Research, Geneva (Switzerland)

    2012-07-01

    Emittance measurements during the LHC proton run 2011 indicated a blow-up of 20 % to 30 % from LHC injection to collisions. This presentation will show the emittance preservation throughout the different parts of the LHC cycle and discuss the current limitations on emittance determination. An overview of emittance preservation through the injector complex as function of bunch intensity will also be given. Possible sources for the observed blow-up and required tests in 2012 will be presented. Possible improvements of emittance diagnostics and analysis tools for 2012 will be shown.

  2. New Method for Determination of Electrically Inactive Phosphorus in n-type Emitters

    OpenAIRE

    Steyer, Michael; Dastgheib-Shirazi, Amir; Hahn, Giso; Terheiden, Barbara

    2015-01-01

    The precise knowledge of the amount and the location in depth of inactive phosphorus in an n-type emitter is still a challenge. As a new approach, we determine the total amount of phosphorus (P dose) in the emitter stepwise in dependence of etching depth with the characterization tool ICP-OES. A comparison of the data with the electrically active P concentration profile measured by ECV allows to determine in which depths electrically inactive phosphorus is present. For a highly doped emitter,...

  3. Single-shot measurements of low emittance beams from laser-plasma accelerators comparing two triggered injection methods

    Science.gov (United States)

    van Tilborg, Jeroen

    2017-10-01

    The success of laser plasma accelerator (LPA) based applications, such as a compact x-ray free electron laser (FEL), relies on the ability to produce electron beams with excellent 6D brightness, where brightness is defined as the ratio of charge to the product of the three normalized emittances. As such, parametric studies of the emittance of LPA generated electron beams are essential. Profiting from a stable and tunable LPA setup, combined with a carefully designed single-shot energy-dispersed emittance diagnostic, we present a direct comparison of charge dependent emittance measurements of electron beams generated by two different injection mechanisms: ionization injection and shock-induced density down-ramp injection. Both injection mechanisms have gained in popularity in recent years due to their demonstrated stable LPA performance. For the down-ramp injection configuration, normalized emittances a factor of two lower were recorded: less than 1 micron at spectral charge densities up to 2 pC/MeV. For both injection mechanisms, a contributing correlation of space charge to the emittance was identified. This measurement technique in general, and these results specifically, are critical to the evaluation of LPA injection methods and development of high-quality LPA beam lines worldwide. This work is supported by the U.S. DOE under Contract No. DE-AC02-05CH11231, by the U.S. DOE NNSA, DNN R&D (NA22), by the National Science Foundation under Grant No. PHY-1415596, and by the Gordon and Betty Moore Foundation under Grant ID GBMF4898.

  4. Pepper-pot diagnostic method to define emittance and Twiss parameters on low energies accelerators

    CERN Document Server

    Dolinska, M E

    2002-01-01

    The new complex mathematical algorithm to determine beam transverse emittance data and the Twiss parameters from intensity measured with pepper-por diagnostic device on rf low energies accelerators is described.

  5. Transverse emittance measurement of high-current single pulse beams using pepper-pot method

    International Nuclear Information System (INIS)

    Ke Jianlin; Zhou Changgeng; Qiu Rui

    2013-01-01

    A pepper pot-imaging plate system has been developed and used to measure the 4-D transverse emittance of a vacuum arc ion source. Single beam pulses of tens to hundreds milliamperes were extracted from the plasma with 64 kV high voltage. An imaging plate was laid after the pepper pot to visualize the ion beamlets passing though the holes on the pepper pot. An application program was developed to show the phase-space distribution and calculate the ellipse and RMS emittances. The normalized RMS emittances are about 6.41 π·mm·mrad in x-direction and 4.61 π·mm·mrad in y-direction. It is shown that the emittance of the vacuum arc ion source is much larger than that of other types of ion sources, which is mainly attributed to the high current and the convex meniscus of this source. (authors)

  6. Method to evaluate steering and alignment algorithms for controlling emittance growth

    International Nuclear Information System (INIS)

    Adolphsen, C.; Raubenheimer, T.

    1993-04-01

    Future linear colliders will likely use sophisticated beam-based alignment and/or steering algorithms to control the growth of the beam emittance in the linac. In this paper, a mathematical framework is presented which simplifies the evaluation of the effectiveness of these algorithms. As an application, a quad alignment that uses beam data taken with the nominal linac optics, and with a scaled optics, is evaluated in terms of the dispersive emittance growth remaining after alignment

  7. Evaluation of new iodinated acridine derivatives for targeted radionuclide therapy of melanoma using {sup 125}I, an Auger electron emitter

    Energy Technology Data Exchange (ETDEWEB)

    Gardette, M.; Papon, J.; Bonnet, M.; Labarre, P.; Miot-Noirault, E.; Madelmont, J. C.; Chezal, J. M.; Moins, N. [UMR 990, INSERM, Universite d' Auvergne, Clermont-Ferrand (France); Desbois, N. [EA 3660, Universite de Bourgogne, Dijon (France); Wu, T. D.; Guerquin-Kern, J. L. [U 759 INSERM, Institute Curie, Orsay (France)

    2013-06-01

    The full text of the publication follows. The increasing incidence of melanoma and the lack of effective therapy on the disseminated form have led to an urgent need for new specific therapies. Several iodo-benzamides or analogs are known to possess specific affinity for melanoma tissue. New hetero-aromatic derivatives have been designed with a cytotoxic moiety and termed DNA intercalating agents. These compounds could be applied in targeted radionuclide therapy using {sup 125}I, Auger electrons emitter which gives high-energetic localized irradiation. Two iodinated acridine derivatives have been reported to present an in vivo kinetic profile conducive to application in targeted radionuclide therapy. The aim of the present study was to perform a preclinical evaluation of these compounds. The DNA intercalating property was confirmed for both compounds. After radiolabeling with {sup 125}I, the two compounds induced in vitro a significant radiotoxicity on B16F0 melanoma cells. The acridine compound, ICF01040, appeared more radio toxic than the acridone compound, ICF01035. While cellular uptake was similar for both compounds, SIMS analysis and in vitro protocol showed a stronger affinity for melanin with ICF01035, which was able to induce a predominant scavenging process in the melanosome and restrict access to the nucleus. Nevertheless, an important radiotoxicity was measured for the two compounds while the nuclear accumulation was low. Indeed, even if nuclear localization remains the main target sensitive to Auger electrons, the cell membrane remains sensitive to {sup 125}I decays. So, these compounds may induce secondary toxic effects of irradiation, such as membrane lipid damage. Conducted to current experiments are evaluate such hypothesis. Taken together, these results suggest that ICF01040 is a better candidate for application in targeted radionuclide therapy using {sup 125}I. The next step will be in vivo evaluation, where high tumoral vectorization gives

  8. Total hemispherical emittance measured at high temperatures by the calorimetric method

    International Nuclear Information System (INIS)

    DiFilippo, F.; Mirtich, M.J.; Banks, B.A.; Stidham, C.; Kussmaul, M.

    1994-01-01

    A calorimetric vacuum emissometer (CVE) capable of measuring total hemispherical emittance of surfaces at elevated temperatures was designed, built, and tested. Several materials with a wide range of emittances were measured in the CVE between 773 to 923 K. These results were compared to values calculated from spectral emittance curves measured in a room temperature Hohlraum reflectometer and in an open-air elevated temperature emissometer. The results differed by as much as 0.2 for some materials but were in closer agreement for the more highly-emitting, diffuse-reflecting samples. The differences were attributed to temperature, atmospheric, and directional effects, and errors in the Hohlraum and emissometer measurements (± 5 percent). The probable error of the CVE measurements was typically less than 1 percent

  9. An easy method for the determination of Ra isotopes and actinide alpha emitters from the same water sample

    International Nuclear Information System (INIS)

    Moron, M.C.; Garcia-Tenorio, R.; Garcia-Montano, E.; Garcia-Leon, M.; Madurga, G.

    1986-01-01

    Radium isotopes and actinide α emitters are easily determined from the same water sample. The Ra fraction is obtained by coprecipitation with Ba, while a Fe coprecipitation is used for the actinides. Both fractions are measured with a gas-flow proportional counter. Additionally the isotopic Ra composition is obtained by measuring at two or three different times the α activity from the Ra-fraction. The method is applied to rain water and drinking water samples. (author)

  10. Standardization of low energy beta and beta-gamma complex emitters by the tracer and the efficiency extrapolation methods

    International Nuclear Information System (INIS)

    Sahagia, M.

    1978-01-01

    The absolute standardization of radioactive solutions of low energy beta emitters and beta-gamma emitters with a high probability of disintegration to the ground state is described; the tracer and the efficiency extrapolation methods were used. Both types of radionuclides were mathematically and physically treated in an unified manner. The theoretical relations between different beta spectra were calculated according to Williams' model and experimentally verified for: 35 S + 60 Co, 35 S + 95 Nb, 147 Pm + 60 Co, 14 C + 95 Nb and two beta branches of 99 Mo. The optimum range of beta efficiency variation was indicated. The basic supposition that all beta efficieny tend to unity in the same time was experimentally verified, using two 192 Ir beta branches. Four computer programs, written in the FORTRAN IV language, were elaborated, for the adequate processing of the experimental data. Good precision coefficients according to international standards were obtained in the absolute standardization of 35 S, 147 Pm, 99 Mo solutions. (author)

  11. Carbon dots—Emerging light emitters for bioimaging, cancer therapy and optoelectronics

    KAUST Repository

    Hola, Katerina; Zhang, Yu; Wang, Yu; Giannelis, Emmanuel P.; Zboril, Radek; Rogach, Andrey L.

    2014-01-01

    © 2014 Elsevier Ltd. All rights reserved. Carbon dots represent an emerging class of fluorescent materials and provide a broad application potential in various fields of biomedicine and optoelectronics. In this review, we introduce various synthetic strategies and basic photoluminescence properties of carbon dots, and then address their advanced in vitro and in vivo bioapplications including cell imaging, photoacoustic imaging, photodynamic therapy and targeted drug delivery. We further consider the applicability of carbon dots as components of light emitting diodes, which include carbon dot based electroluminescence, optical down-conversion, and hybrid plasmonic devices. The review concludes with an outlook towards future developments of these emerging light-emitting materials.

  12. Carbon dots—Emerging light emitters for bioimaging, cancer therapy and optoelectronics

    KAUST Repository

    Hola, Katerina

    2014-10-01

    © 2014 Elsevier Ltd. All rights reserved. Carbon dots represent an emerging class of fluorescent materials and provide a broad application potential in various fields of biomedicine and optoelectronics. In this review, we introduce various synthetic strategies and basic photoluminescence properties of carbon dots, and then address their advanced in vitro and in vivo bioapplications including cell imaging, photoacoustic imaging, photodynamic therapy and targeted drug delivery. We further consider the applicability of carbon dots as components of light emitting diodes, which include carbon dot based electroluminescence, optical down-conversion, and hybrid plasmonic devices. The review concludes with an outlook towards future developments of these emerging light-emitting materials.

  13. Comparison of Different Methods for Transverse Emittance Measurement and Recent Results from LEP

    CERN Document Server

    Bovet, Claude; Jung, R

    1997-01-01

    The knowledge of its position and angular transverse distributions is of utmost interest to assess the good behaviour of a beam within an accelerator. After a short reminder of beam "emittance" definitions, a review is made of various measurement techniques used so far both in single pass machines and colliders. Results of measurements made at CERN in the future LHC injection complex and in LEP are presented and discussed.

  14. Low emittance electron storage rings

    Science.gov (United States)

    Levichev, E. B.

    2018-01-01

    Low-emittance electron (positron) beams are essential for synchrotron light sources, linear collider damping rings, and circular Crab Waist colliders. In this review, the principles and methods of emittance minimization are discussed, prospects for developing relativistic electron storage rings with small beam phase volume are assessed, and problems related to emittance minimization are examined together with their possible solutions. The special features and engineering implementation aspects of various facilities are briefly reviewed.

  15. A Single RF Emitter-Based Indoor Navigation Method for Autonomous Service Robots

    Directory of Open Access Journals (Sweden)

    Tyrone Sherwin

    2018-02-01

    Full Text Available Location-aware services are one of the key elements of modern intelligent applications. Numerous real-world applications such as factory automation, indoor delivery, and even search and rescue scenarios require autonomous robots to have the ability to navigate in an unknown environment and reach mobile targets with minimal or no prior infrastructure deployment. This research investigates and proposes a novel approach of dynamic target localisation using a single RF emitter, which will be used as the basis of allowing autonomous robots to navigate towards and reach a target. Through the use of multiple directional antennae, Received Signal Strength (RSS is compared to determine the most probable direction of the targeted emitter, which is combined with the distance estimates to improve the localisation performance. The accuracy of the position estimate is further improved using a particle filter to mitigate the fluctuating nature of real-time RSS data. Based on the direction information, a motion control algorithm is proposed, using Simultaneous Localisation and Mapping (SLAM and A* path planning to enable navigation through unknown complex environments. A number of navigation scenarios were developed in the context of factory automation applications to demonstrate and evaluate the functionality and performance of the proposed system.

  16. A Single RF Emitter-Based Indoor Navigation Method for Autonomous Service Robots.

    Science.gov (United States)

    Sherwin, Tyrone; Easte, Mikala; Chen, Andrew Tzer-Yeu; Wang, Kevin I-Kai; Dai, Wenbin

    2018-02-14

    Location-aware services are one of the key elements of modern intelligent applications. Numerous real-world applications such as factory automation, indoor delivery, and even search and rescue scenarios require autonomous robots to have the ability to navigate in an unknown environment and reach mobile targets with minimal or no prior infrastructure deployment. This research investigates and proposes a novel approach of dynamic target localisation using a single RF emitter, which will be used as the basis of allowing autonomous robots to navigate towards and reach a target. Through the use of multiple directional antennae, Received Signal Strength (RSS) is compared to determine the most probable direction of the targeted emitter, which is combined with the distance estimates to improve the localisation performance. The accuracy of the position estimate is further improved using a particle filter to mitigate the fluctuating nature of real-time RSS data. Based on the direction information, a motion control algorithm is proposed, using Simultaneous Localisation and Mapping (SLAM) and A* path planning to enable navigation through unknown complex environments. A number of navigation scenarios were developed in the context of factory automation applications to demonstrate and evaluate the functionality and performance of the proposed system.

  17. A bone marrow toxicity model for 223Ra alpha-emitter radiopharmaceutical therapy

    International Nuclear Information System (INIS)

    Hobbs, Robert F; Song Hong; Sgouros, George; Watchman, Christopher J; Bolch, Wesley E; Aksnes, Anne-Kirsti; Ramdahl, Thomas; Flux, Glenn D

    2012-01-01

    Ra-223, an α-particle emitting bone-seeking radionuclide, has recently been used in clinical trials for osseous metastases of prostate cancer. We investigated the relationship between absorbed fraction-based red marrow dosimetry and cell level-dosimetry using a model that accounts for the expected localization of this agent relative to marrow cavity architecture. We show that cell level-based dosimetry is essential to understanding potential marrow toxicity. The GEANT4 software package was used to create simple spheres representing marrow cavities. Ra-223 was positioned on the trabecular bone surface or in the endosteal layer and simulated for decay, along with the descendants. The interior of the sphere was divided into cell-size voxels and the energy was collected in each voxel and interpreted as dose cell histograms. The average absorbed dose values and absorbed fractions were also calculated in order to compare those results with previously published values. The absorbed dose was predominantly deposited near the trabecular surface. The dose cell histogram results were used to plot the percentage of cells that received a potentially toxic absorbed dose (2 or 4 Gy) as a function of the average absorbed dose over the marrow cavity. The results show (1) a heterogeneous distribution of cellular absorbed dose, strongly dependent on the position of the cell within the marrow cavity; and (2) that increasing the average marrow cavity absorbed dose, or equivalently, increasing the administered activity resulted in only a small increase in potential marrow toxicity (i.e. the number of cells receiving more than 4 or 2 Gy), for a range of average marrow cavity absorbed doses from 1 to 20 Gy. The results from the trabecular model differ markedly from a standard absorbed fraction method while presenting comparable average dose values. These suggest that increasing the amount of radioactivity may not substantially increase the risk of toxicity, a result unavailable to the

  18. Modified inorganic nanoparticles as vehicles for alpha emitters in radionuclide therapy

    International Nuclear Information System (INIS)

    Piotrowska, A.; Leszczuk, E.; Koźmiński, P.; Bilewicz, A.; Morgenstern, A.; Bruchertseifer, F.

    2014-01-01

    The TiO 2 nanoparticles have unique properties like: high specific surface, high affinity for multivalent cations and simple way of synthesis, which are useful in the process of labelling. Commercially available (e.g. P-25 Degussa) and synthesised in our laboratory nanoparticles were used in experiments. The nanoparticles were characterized by TEM, SEM, DLS and NanoSight techniques. In the experiments, two different methods of labeling are tested. The first one was based on the possibility of formation strong bonds with certain cations on the surface of the nanoparticles. In the 65 second one, TiO 2 nanoparticles were doped with 225 Ac during the process of synthesis. In both cases, high yields of labelling (>99%) was obtained. Afterwards, the stability of labelled nanoparticles was examined in 0.9 % NaCl, 10 -3 M EDTA, solutions of biologically active substances (cysteine, glutathione) and human serum. In case of TiO 2 nanoparticles labelled with 225 Ac, which was built in the crystalline structure, the leakage of 225 Ac and its daughter radionuclides was not significant in any of solutions, even when the incubation time was extended to 10 days. In the case of nanoparticles with adsorbed 225 Ac on surface the leakage in serum was slightly higher, but still insignificant. Also the NaA nanozeolite as a carrier for radium radionuclides has been studied. 224 Ra and 225 Ra, the α-particle emitting radionuclides, have been absorbed in the nanometer-sized NaA zeolite through simple ion-exchange. 224,225 Ra-nanozeolites have shown very good stability in solutions containing: physiological salt, EDTA, amino acid and human serum. To make NaA nanozeolite particles dispersed in water their surface has been modified with silane coupling agent containing poly (ethylene glycol) (PEG) molecules. To obtain conjugates specific for receptors on glioma cancer cells short peptide substance P were covalently attached to the PEG-TiO 2 and PEG-nanozeolite surface. The obtained

  19. A saturable repair model for radionuclide therapy using low LET radiation emitters

    International Nuclear Information System (INIS)

    Calderon, Carlos F.; Joaquin Gonzalez; Guido Martin

    2004-01-01

    distributed inside the tumor volume. Close-form expressions were obtained to calculate the effective irradiation time, effective dose and therapeutic efficacy. The results were compared with linear-quadratic model (LQ) predictions at low dose rate in view of saturable repair model could show similar prediction of LQ model like occurs with other sublethal damage model which offers a mechanistic interpretation for LQ model. Methods: The equation system for the model proposed by Sanchez-Reyes, modified by inclusion of cell proliferation. Conclusion: The modification of radiobiological model proposed by Sanchez-Reyes presented here let us make prediction on cell response under irradiation schemes in RN. The model will produce similar results to those one which could be obtained with LQ model at low dose rate. The formalism presented here let us to determine parameters which could be used in treatment planning for RN. (authors)

  20. Auger electron emitter against multiple myeloma - targeted endo-radio-therapy with 125I-labeled thymidine analogue 5-iodo-4'-thio-2'-deoxyuridine

    International Nuclear Information System (INIS)

    Morgenroth, Agnieszka; Dinger, Cornelia; Zlatopolskiy, Boris D.; Al-Momani, Ehab; Glatting, Gerhard; Mottaghy, Felix M.; Reske, Sven N.

    2011-01-01

    Introduction: Multiple myeloma (MM) is a plasma cell malignancy characterized by accumulation of malignant, terminally differentiated B cells in the bone marrow. Despite advances in therapy, MM remains an incurable disease. Novel therapeutic approaches are, therefore, urgently needed. Auger electron-emitting radiopharmaceuticals are attractive for targeted nano-irradiation therapy, given that DNA of malignant cells is selectively addressed. Here we evaluated the antimyeloma potential of the Auger electron-emitting thymidine analogue 125 I-labeled 5-iodo-4'-thio-2'-deoxyuridine ([ 125 I]ITdU). Methods: Cellular uptake and DNA incorporation of [ 125 I]ITdU were determined in fluorodeoxyuridine-pretreated KMS12BM, U266, dexamethasone-sensitive MM1.S and -resistant MM1.R cell lines. The effect of stimulation with interleukin 6 (IL6) or insulin-like growth factor 1 (IGF1) on the intracellular incorporation of [ 125 I]ITdU was investigated in cytokine-sensitive MM1.S and MM1.R cell lines. Apoptotic cells were identified using Annexin V. Cleavage of caspase 3 and PARP was visualized by Western blot. DNA fragmentation was investigated using laddering assay. Therapeutic efficiency of [ 125 I]ITdU was proven by clonogenic assay. Results: [ 125 I]ITdU was shown to be efficiently incorporated into DNA of malignant cells, providing a promising mechanism for delivering highly toxic Auger radiation emitters into tumor DNA. [ 125 I]ITdU had a potent antimyeloma effect in cell lines representing distinct disease stages and, importantly, in cell lines sensitive or resistant to the conventional therapeutic agent, but was not toxic for normal plasma and bone marrow stromal cells. Furthermore, [ 125 I]ITdU abrogated the protective actions of IL6 and IGF1 on MM cells. [ 125 I]ITdU induced massive damage in the DNA of malignant plasma cells, which resulted in efficient inhibition of clonogenic growth. Conclusion: These studies may provide a novel treatment strategy for overcoming

  1. Production and dosimetric aspects of the potent Auger emitter {sup 58m}Co for targeted radionuclide therapy of small tumors

    Energy Technology Data Exchange (ETDEWEB)

    Thisgaard, H.; Elema, D.R.; Jensen, M. [PET and Cyclotron Unit, Nuclear Medicine Department, Odense University Hospital, Sdr. Boulevard 29, DK-5000 Odense, Denmark and Institute of Clinical Research, University of Southern Denmark, Winsloewparken 19, DK-5000 Odense (Denmark); The Hevesy Laboratory, Risoe National Laboratory for Sustainable Energy, Technical University of Denmark, P.O. Box 49, DK-4000 Roskilde (Denmark)

    2011-08-15

    Purpose: Based on theoretical calculations, the Auger emitter {sup 58m}Co has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state {sup 58g}Co is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of {sup 58m}Co. The impact of {sup 58g}Co as a {beta}{sup +}- and {gamma}-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of {sup 58m}Co and {sup 58g}Co using a low-energy cyclotron. Also, the cellular S-values for {sup 58m}Co have been calculated and are presented here for the first time. Methods: {sup 58m}Co was produced via the {sup 58}Fe(p,n){sup 58m}Co nuclear reaction on highly enriched {sup 58}Fe metal. In addition, radiochemical separations of produced radio-cobalt from {sup nat}Fe target material were performed. The theoretical subcellular dosimetry calculations for {sup 58m}Co and {sup 58g}Co were performed using the MIRD formalism, and the impact of the increasing ground state impurity on the tumor-to-normal-tissue dose ratios (TND) per disintegration as a function of time after end of bombardment (EOB) was calculated. Results: 192 {+-} 8 MBq of {sup 58m}Co was produced in the irradiation corresponding to a production yield of 10.7 MBq/{mu}Ah. The activity of {sup 58g}Co was measured to be 0.85% {+-} 0.04% of the produced {sup 58m}Co activity at EOB. The radio-cobalt yields in the rapid separations were measured to be >97% with no detectable iron contaminations in the cobalt fractions. Due to the unavoidable coproduction and ingrowth of the long-lived ground state {sup 58g}Co, the TND and the potency of the {sup 58m}Co decrease with time after EOB. If a future treatment with a {sup 58m}Co labeled compound is not initiated before, e.g., 21 h after EOB, the

  2. Shielding in ungated field emitter arrays

    Energy Technology Data Exchange (ETDEWEB)

    Harris, J. R. [U.S. Navy Reserve, Navy Operational Support Center New Orleans, New Orleans, Louisiana 70143 (United States); Jensen, K. L. [Code 6854, Naval Research Laboratory, Washington, D.C. 20375 (United States); Shiffler, D. A. [Directed Energy Directorate, Air Force Research Laboratory, Albuquerque, New Mexico 87117 (United States); Petillo, J. J. [Leidos, Billerica, Massachusetts 01821 (United States)

    2015-05-18

    Cathodes consisting of arrays of high aspect ratio field emitters are of great interest as sources of electron beams for vacuum electronic devices. The desire for high currents and current densities drives the cathode designer towards a denser array, but for ungated emitters, denser arrays also lead to increased shielding, in which the field enhancement factor β of each emitter is reduced due to the presence of the other emitters in the array. To facilitate the study of these arrays, we have developed a method for modeling high aspect ratio emitters using tapered dipole line charges. This method can be used to investigate proximity effects from similar emitters an arbitrary distance away and is much less computationally demanding than competing simulation approaches. Here, we introduce this method and use it to study shielding as a function of array geometry. Emitters with aspect ratios of 10{sup 2}–10{sup 4} are modeled, and the shielding-induced reduction in β is considered as a function of tip-to-tip spacing for emitter pairs and for large arrays with triangular and square unit cells. Shielding is found to be negligible when the emitter spacing is greater than the emitter height for the two-emitter array, or about 2.5 times the emitter height in the large arrays, in agreement with previously published results. Because the onset of shielding occurs at virtually the same emitter spacing in the square and triangular arrays, the triangular array is preferred for its higher emitter density at a given emitter spacing. The primary contribution to shielding in large arrays is found to come from emitters within a distance of three times the unit cell spacing for both square and triangular arrays.

  3. submitter Proton therapy treatment monitoring with the DoPET system: activity range, positron emitters evaluation and comparison with Monte Carlo predictions

    CERN Document Server

    Muraro, S; Belcari, N; Bisogni, M G; Camarlinghi, N; Cristoforetti, L; Guerra, A Del; Ferrari, A; Fracchiolla, F; Morrocchi, M; Righetto, R; Sala, P; Schwarz, M; Sportelli, G; Topi, A; Rosso, V

    2017-01-01

    Ion beam irradiations can deliver conformal dose distributions minimizing damage to healthy tissues thanks to their characteristic dose profiles. Nevertheless, the location of the Bragg peak can be affected by different sources of range uncertainties: a critical issue is the treatment verification. During the treatment delivery, nuclear interactions between the ions and the irradiated tissues generate β+ emitters: the detection of this activity signal can be used to perform the treatment monitoring if an expected activity distribution is available for comparison. Monte Carlo (MC) codes are widely used in the particle therapy community to evaluate the radiation transport and interaction with matter. In this work, FLUKA MC code was used to simulate the experimental conditions of irradiations performed at the Proton Therapy Center in Trento (IT). Several mono-energetic pencil beams were delivered on phantoms mimicking human tissues. The activity signals were acquired with a PET system (DoPET) based on two plana...

  4. A Novel Location-Awareness Method Using CubeSats for Locating the Spot Beam Emitters of Geostationary Communications Satellites

    Directory of Open Access Journals (Sweden)

    Weicai Yang

    2018-01-01

    Full Text Available As more spacecraft are launched into the Geostationary Earth Orbit (GEO belt, the possibility of fatal collisions or unnecessary interference between spacecraft increases. In this paper, a new location-awareness method that uses CubeSats is proposed to assist with radiofrequency (RF domain verification by means of awareness and identification of the positions of the spot beam emitters of communications satellites in geostationary orbit. By flying a CubeSat (or a constellation of CubeSats through the coverage area of a spot beam, the spot beam emitter’s position is identified and the spot beam’s pattern knowledge is characterized. The geometry, the equations of motion of the spacecraft, the measurement process, and the filtering equations in a location system are addressed with respect to the location methods investigated in this study. A realistic scenario in which a CubeSat receives signals from GEO communications satellites is simulated using the Systems Tool Kit (STK. The results of the simulation and the analysis presented in this study provide a thorough verification of the performance of the location-awareness method.

  5. Properties of multiple field ion emitters of tungsten and a simple method for improving their ionization efficiency

    International Nuclear Information System (INIS)

    Okuyama, F.; Beckey, H.D.

    1978-01-01

    The ion emission properties of the multiple tungsten emitters developed recently for field ionization mass spectrometry were investigated with the aid of a sector type mass spectrometer at emitter-cathode voltages of 10-15 kV using acetone, n-heptane and benzene as test substances. The emitters, which comprised a 10-μm tungsten filament bearing thickly arrayed microneedles of tungsten, produced very weak and unstable signals at voltages of about 10 kV, but increasing the voltage to 14 kV led to intensifying ion currents high enough to yield mass spectra of satisfactory quality. During the course of the experiments, it was observed that nucleating tungsten carbide particles on the emitter surface by means of a high-field chemical reaction with benzene vapours can significanlty promote the field ionization of gas molecules, presumably as a result of the field enhancement resulting from roughening of the surface. (Auth.)

  6. Spherical proton emitters

    International Nuclear Information System (INIS)

    Berg, S.; Semmes, P.B.; Nazarewicz, W.

    1997-01-01

    Various theoretical approaches to proton emission from spherical nuclei are investigated, and it is found that all the methods employed give very similar results. The calculated decay widths are found to be qualitatively insensitive to the parameters of the proton-nucleus potential, i.e., changing the potential parameters over a fairly large range typically changes the decay width by no more than a factor of ∼3. Proton half-lives of observed heavy proton emitters are, in general, well reproduced by spherical calculations with the spectroscopic factors calculated in the independent quasiparticle approximation. The quantitative agreement with experimental data obtained in our study requires that the parameters of the proton-nucleus potential be chosen carefully. It also suggests that deformed proton emitters will provide invaluable spectroscopic information on the angular momentum decomposition of single-proton orbitals in deformed nuclei. copyright 1997 The American Physical Society

  7. An analysis of MCNP cross-sections and tally methods for low-energy photon emitters.

    Science.gov (United States)

    Demarco, John J; Wallace, Robert E; Boedeker, Kirsten

    2002-04-21

    Monte Carlo calculations are frequently used to analyse a variety of radiological science applications using low-energy (10-1000 keV) photon sources. This study seeks to create a low-energy benchmark for the MCNP Monte Carlo code by simulating the absolute dose rate in water and the air-kerma rate for monoenergetic point sources with energies between 10 keV and 1 MeV. The analysis compares four cross-section datasets as well as the tally method for collision kerma versus absorbed dose. The total photon attenuation coefficient cross-section for low atomic number elements has changed significantly as cross-section data have changed between 1967 and 1989. Differences of up to 10% are observed in the photoelectric cross-section for water at 30 keV between the standard MCNP cross-section dataset (DLC-200) and the most recent XCOM/NIST tabulation. At 30 keV, the absolute dose rate in water at 1.0 cm from the source increases by 7.8% after replacing the DLC-200 photoelectric cross-sections for water with those from the XCOM/NIST tabulation. The differences in the absolute dose rate are analysed when calculated with either the MCNP absorbed dose tally or the collision kerma tally. Significant differences between the collision kerma tally and the absorbed dose tally can occur when using the DLC-200 attenuation coefficients in conjunction with a modern tabulation of mass energy-absorption coefficients.

  8. Etude de la mesure des emittances transverses d'un faisceau par la methode des gradients. Application au cas d'une focalisation par solenoide

    CERN Document Server

    M'Garrech, S

    2002-01-01

    Within the framework of the ALTO project (Linear Accelerator near the Orsay Tandem), IPNO will recover the LAL station NEPAL, which will be used as the ALTO injecting system. To calculate the beam optics through the linear accelerator, it is necessary to determine the electron beam emittance at the exit of the buncher station. There are several methods to determine this emittance: direct methods, like the Pepper Pot technique, and indirect ones, like the three distances method and the three gradients one. The latter requires a variable optic element (quadrupole, solenoid...). In the case of the use of a solenoid, the horizontal and vertical motions are coupled, which implies an additional difficulty for the analysis of the measurements. The main goal of this report is to identify and to solve these mathematical difficulties, so as to determine at last the initial emittance. The treated example comes from a paper by R.Chehab et al [12], the code used is BETA, and resolution is done using the last square method...

  9. Proton therapy treatment monitoring with the DoPET system: activity range, positron emitters evaluation and comparison with Monte Carlo predictions

    Science.gov (United States)

    Muraro, S.; Battistoni, G.; Belcari, N.; Bisogni, M. G.; Camarlinghi, N.; Cristoforetti, L.; Del Guerra, A.; Ferrari, A.; Fracchiolla, F.; Morrocchi, M.; Righetto, R.; Sala, P.; Schwarz, M.; Sportelli, G.; Topi, A.; Rosso, V.

    2017-12-01

    Ion beam irradiations can deliver conformal dose distributions minimizing damage to healthy tissues thanks to their characteristic dose profiles. Nevertheless, the location of the Bragg peak can be affected by different sources of range uncertainties: a critical issue is the treatment verification. During the treatment delivery, nuclear interactions between the ions and the irradiated tissues generate β+ emitters: the detection of this activity signal can be used to perform the treatment monitoring if an expected activity distribution is available for comparison. Monte Carlo (MC) codes are widely used in the particle therapy community to evaluate the radiation transport and interaction with matter. In this work, FLUKA MC code was used to simulate the experimental conditions of irradiations performed at the Proton Therapy Center in Trento (IT). Several mono-energetic pencil beams were delivered on phantoms mimicking human tissues. The activity signals were acquired with a PET system (DoPET) based on two planar heads, and designed to be installed along the beam line to acquire data also during the irradiation. Different acquisitions are analyzed and compared with the MC predictions, with a special focus on validating the PET detectors response for activity range verification.

  10. The low-energy β(-) and electron emitter (161)Tb as an alternative to (177)Lu for targeted radionuclide therapy.

    Science.gov (United States)

    Lehenberger, Silvia; Barkhausen, Christoph; Cohrs, Susan; Fischer, Eliane; Grünberg, Jürgen; Hohn, Alexander; Köster, Ulli; Schibli, Roger; Türler, Andreas; Zhernosekov, Konstantin

    2011-08-01

    The low-energy β(-) emitter (161)Tb is very similar to (177)Lu with respect to half-life, beta energy and chemical properties. However, (161)Tb also emits a significant amount of conversion and Auger electrons. Greater therapeutic effect can therefore be expected in comparison to (177)Lu. It also emits low-energy photons that are useful for gamma camera imaging. The (160)Gd(n,γ)(161)Gd→(161)Tb production route was used to produce (161)Tb by neutron irradiation of massive (160)Gd targets (up to 40 mg) in nuclear reactors. A semiautomated procedure based on cation exchange chromatography was developed and applied to isolate no carrier added (n.c.a.) (161)Tb from the bulk of the (160)Gd target and from its stable decay product (161)Dy. (161)Tb was used for radiolabeling DOTA-Tyr3-octreotate; the radiolabeling profile was compared to the commercially available n.c.a. (177)Lu. A (161)Tb Derenzo phantom was imaged using a small-animal single-photon emission computed tomography camera. Up to 15 GBq of (161)Tb was produced by long-term irradiation of Gd targets. Using a cation exchange resin, we obtained 80%-90% of the available (161)Tb with high specific activity, radionuclide and chemical purity and in quantities sufficient for therapeutic applications. The (161)Tb obtained was of the quality required to prepare (161)Tb-DOTA-Tyr3-octreotate. We were able to produce (161)Tb in n.c.a. form by irradiating highly enriched (160)Gd targets; it can be obtained in the quantity and quality required for the preparation of (161)Tb-labeled therapeutic agents. Copyright © 2011 Elsevier Inc. All rights reserved.

  11. The FLUKA code for application of Monte Carlo methods to promote high precision ion beam therapy

    CERN Document Server

    Parodi, K; Cerutti, F; Ferrari, A; Mairani, A; Paganetti, H; Sommerer, F

    2010-01-01

    Monte Carlo (MC) methods are increasingly being utilized to support several aspects of commissioning and clinical operation of ion beam therapy facilities. In this contribution two emerging areas of MC applications are outlined. The value of MC modeling to promote accurate treatment planning is addressed via examples of application of the FLUKA code to proton and carbon ion therapy at the Heidelberg Ion Beam Therapy Center in Heidelberg, Germany, and at the Proton Therapy Center of Massachusetts General Hospital (MGH) Boston, USA. These include generation of basic data for input into the treatment planning system (TPS) and validation of the TPS analytical pencil-beam dose computations. Moreover, we review the implementation of PET/CT (Positron-Emission-Tomography / Computed- Tomography) imaging for in-vivo verification of proton therapy at MGH. Here, MC is used to calculate irradiation-induced positron-emitter production in tissue for comparison with the +-activity measurement in order to infer indirect infor...

  12. Modeling and analysis of all the positron emitters simulation steps generated during the treatment phase in proton-therapy - from the beam to the PET camera - for the follow-up of the irradiations

    International Nuclear Information System (INIS)

    Ty, C.V.N.

    2012-01-01

    The proton-therapy is an innovative technique for cancer treatment in critical areas, such as the eye or the head. Even though the interaction of protons with human tissues is a well-known physical phenomenon which gives rise to the proton-therapy, there are uncertainties on the proton trajectory due to heterogeneities in the irradiated tissue, the calculation of the beam parameters in the planning treatment affects the theoretical benefits of the protons and the chosen dose delivery process. Thus, methods for irradiation quality control have been suggested. Most of them rely on utilizing the mapping of the positron emitters generated during the irradiation. They are detectable and quantifiable thanks to the use of the PET (positron emitter tomography), a medical imaging technique mainly used for the cancer expansion assessment. PET acquisitions were proposed and then realized on phantoms and patients after proton-therapy. The quality control relies on comparing the measured radioactive distribution to the simulated β + distribution. The modeling of the positron activity generated by protons in the irradiated area can be divided into three steps: the simulation of the proton beam, the modeling of the proton interactions in the irradiated object and the modeling of the PET acquisition. Different ways of simulating these steps are possible. This PhD work suggests different ways of modeling the three steps and evaluates theirs benefits for the irradiation quality control. We have restrained our evaluation to the verification of the proton range and to the uncertainties related to the proton range. This research work utilizes on irradiations in homogenous and inhomogeneous areas in a head model. We have compared the uncertainties on the proton range measured thanks to the following β + distributions: 1) A β + distribution obtained by modeling the irradiation with a proton beam simulated analytically and simulated using the complete Monte Carlo method; 2) A Monte

  13. Quantitative single-particle digital autoradiography with α-particle emitters for targeted radionuclide therapy using the iQID camera

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Brian W., E-mail: brian.miller@pnnl.gov [Pacific Northwest National Laboratory, Richland, Washington 99354 and College of Optical Sciences, The University of Arizona, Tucson, Arizona 85719 (United States); Frost, Sofia H. L.; Frayo, Shani L.; Kenoyer, Aimee L.; Santos, Erlinda; Jones, Jon C.; Orozco, Johnnie J. [Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 (United States); Green, Damian J.; Press, Oliver W.; Pagel, John M.; Sandmaier, Brenda M. [Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 and Department of Medicine, University of Washington, Seattle, Washington 98195 (United States); Hamlin, Donald K.; Wilbur, D. Scott [Department of Radiation Oncology, University of Washington, Seattle, Washington 98195 (United States); Fisher, Darrell R. [Dade Moeller Health Group, Richland, Washington 99354 (United States)

    2015-07-15

    Purpose: Alpha-emitting radionuclides exhibit a potential advantage for cancer treatments because they release large amounts of ionizing energy over a few cell diameters (50–80 μm), causing localized, irreparable double-strand DNA breaks that lead to cell death. Radioimmunotherapy (RIT) approaches using monoclonal antibodies labeled with α emitters may thus inactivate targeted cells with minimal radiation damage to surrounding tissues. Tools are needed to visualize and quantify the radioactivity distribution and absorbed doses to targeted and nontargeted cells for accurate dosimetry of all treatment regimens utilizing α particles, including RIT and others (e.g., Ra-223), especially for organs and tumors with heterogeneous radionuclide distributions. The aim of this study was to evaluate and characterize a novel single-particle digital autoradiography imager, the ionizing-radiation quantum imaging detector (iQID) camera, for use in α-RIT experiments. Methods: The iQID camera is a scintillator-based radiation detection system that images and identifies charged-particle and gamma-ray/x-ray emissions spatially and temporally on an event-by-event basis. It employs CCD-CMOS cameras and high-performance computing hardware for real-time imaging and activity quantification of tissue sections, approaching cellular resolutions. In this work, the authors evaluated its characteristics for α-particle imaging, including measurements of intrinsic detector spatial resolutions and background count rates at various detector configurations and quantification of activity distributions. The technique was assessed for quantitative imaging of astatine-211 ({sup 211}At) activity distributions in cryosections of murine and canine tissue samples. Results: The highest spatial resolution was measured at ∼20 μm full width at half maximum and the α-particle background was measured at a rate as low as (2.6 ± 0.5) × 10{sup −4} cpm/cm{sup 2} (40 mm diameter detector area

  14. Minimum emittance in TBA and MBA lattices

    Science.gov (United States)

    Xu, Gang; Peng, Yue-Mei

    2015-03-01

    For reaching a small emittance in a modern light source, triple bend achromats (TBA), theoretical minimum emittance (TME) and even multiple bend achromats (MBA) have been considered. This paper derived the necessary condition for achieving minimum emittance in TBA and MBA theoretically, where the bending angle of inner dipoles has a factor of 31/3 bigger than that of the outer dipoles. Here, we also calculated the conditions attaining the minimum emittance of TBA related to phase advance in some special cases with a pure mathematics method. These results may give some directions on lattice design.

  15. Minimum emittance in TBA and MBA lattices

    International Nuclear Information System (INIS)

    Xu Gang; Peng Yuemei

    2015-01-01

    For reaching a small emittance in a modern light source, triple bend achromats (TBA), theoretical minimum emittance (TME) and even multiple bend achromats (MBA) have been considered. This paper derived the necessary condition for achieving minimum emittance in TBA and MBA theoretically, where the bending angle of inner dipoles has a factor of 3 1/3 bigger than that of the outer dipoles. Here, we also calculated the conditions attaining the minimum emittance of TBA related to phase advance in some special cases with a pure mathematics method. These results may give some directions on lattice design. (authors)

  16. Emittance investigation of RF photo-injector

    CERN Document Server

    Yang Mao Rong; Li Zheng; Li Ming; Xu Zhou

    2002-01-01

    A high-power laser beam illuminates a photocathode surface placed on an end wall of an RF cavity. The emitted electrons are accelerated immediately to a relativistic energy by the strong RF find in the cavity. But space charge effect induces beam emittance growth especially near the cathode where the electrons are still nonrelativistic. The author analyzes the factors which lead the transverse emittance growth and method how to resolve this problem. After introducing solenoidal focusing near the photocathode, the beam emittance growth is suppressed dramatically. The beam emittance is given also after compensation and simulation results. The measurements show these results are coincident

  17. Measuring emittances and sigma matrices

    International Nuclear Information System (INIS)

    Rees, J.; Rivkin, L.

    1984-03-01

    The method used for measuring emittance at the SLAC Linac and the linear collider damping ring is described. The basis of the method is derived using one two-by-two matrix to specify the state of the input beam (sigma matrix) and another to describe the lens-drift transport system (R-matrix)

  18. Methods of Feminist Family Therapy Supervision.

    Science.gov (United States)

    Prouty, Anne M.; Thomas, Volker; Johnson, Scott; Long, Janie K.

    2001-01-01

    Presents three supervision methods which emerged from a qualitative study of the experiences of feminist family therapy supervisors and the therapists they supervised: the supervision contract, collaborative methods, and hierarchical methods. Provides a description of the participants' experiences of these methods and discusses their fit with…

  19. Emittance measurements of the CLIO electron beam

    Science.gov (United States)

    Chaput, R.; Devanz, G.; Joly, P.; Kergosien, B.; Lesrel, J.

    1997-02-01

    We have designed a setup to measure the transverse emittance at the CLIO accelerator exit, based on the "3 gradients" method. The beam transverse size is measured simply by scanning it with a steering coil across a fixed jaw and recording the transmitted current, at various quadrupole strengths. A code then performs a complete calculation of the emittance using the transfer matrix of the quadrupole instead of the usual classical lens approximation. We have studied the influence of various parameters on the emittance: Magnetic field on the e-gun and the peak current. We have also improved a little the emittance by replacing a mismatched pipe between the buncher and accelerating section to avoid wake-field effects; The resulting improvements of the emittance have led to an increase in the FEL emitted power.

  20. A novel method to achieve selective emitter for silicon solar cell using low cost pattern-able a-Si thin films as the semi-transparent phosphorus diffusion barrier

    International Nuclear Information System (INIS)

    Chen, Da Ming; Liang, Zong Cun; Zhuang, Lin; Lin, Yang Huan; Shen, Hui

    2012-01-01

    Highlights: ► a-Si thin films as semitransparent phosphorus diffusion barriers for solar cell. ► a-Si thin films on silicon wafers were patterned by the alkaline solution. ► Selective emitter was formed with patterned a-Si as diffusion barrier for solar cell. -- Abstract: Selective emitter for silicon solar cell was realized by employing a-Si thin films as the semi-transparent diffusion barrier. The a-Si thin films with various thicknesses (∼10–40 nm) were deposited by the electron-beam evaporation technique. Emitters with sheet resistances from 37 to 145 Ω/□ were obtained via POCl 3 diffusion process. The thickness of the a-Si diffusion barrier was optimized to be 15 nm for selective emitter in our work. Homemade mask which can dissolve in ethanol was screen-printed on a-Si film to make pattern. The a-Si film was then patterned in KOH solution to form finger-like design. Selective emitter was obtainable with one-step diffusion with patterned a-Si film on. Combinations of sheet resistances for the high-/low-level doped regions of 39.8/112.1, 36.2/88.8, 35.4/73.9 were obtained. These combinations are suitable for screen-printed solar cells. This preparation method of selective emitter based on a-Si diffusion barrier is a promising approach for low cost industrial manufacturing.

  1. Mixed methods research in music therapy research.

    Science.gov (United States)

    Bradt, Joke; Burns, Debra S; Creswell, John W

    2013-01-01

    Music therapists have an ethical and professional responsibility to provide the highest quality care possible to their patients. Much of the time, high quality care is guided by evidence-based practice standards that integrate the most current, available research in making decisions. Accordingly, music therapists need research that integrates multiple ways of knowing and forms of evidence. Mixed methods research holds great promise for facilitating such integration. At this time, there have not been any methodological articles published on mixed methods research in music therapy. The purpose of this article is to introduce mixed methods research as an approach to address research questions relevant to music therapy practice. This article describes the core characteristics of mixed methods research, considers paradigmatic issues related to this research approach, articulates major challenges in conducting mixed methods research, illustrates four basic designs, and provides criteria for evaluating the quality of mixed methods articles using examples of mixed methods research from the music therapy literature. Mixed methods research offers unique opportunities for strengthening the evidence base in music therapy. Recommendations are provided to ensure rigorous implementation of this research approach.

  2. Alpha particle emitters in medicine

    International Nuclear Information System (INIS)

    Fisher, D.R.

    1989-09-01

    Radiation-induced cancer of bone, liver and lung has been a prominent harmful side-effect of medical applications of alpha emitters. In recent years, however, the potential use of antibodies labeled with alpha emitting radionuclides against cancer has seemed promising because alpha particles are highly effective in cell killing. High dose rates at high LET, effectiveness under hypoxic conditions, and minimal expectancy of repair are additional advantages of alpha emitters over antibodies labeled with beta emitting radionuclides for cancer therapy. Cyclotron-produced astatine-211 ( 211 At) and natural bismuth-212 ( 212 Bi) have been proposed and are under extensive study in the United States and Europe. Radium-223 ( 223 Ra) also has favorable properties as a potential alpha emitting label, including a short-lived daughter chain with four alpha emissions. The radiation dosimetry of internal alpha emitters is complex due to nonuniformly distributed sources, short particle tracks, and high relative specific ionization. The variations in dose at the cellular level may be extreme. Alpha-particle radiation dosimetry, therefore, must involve analysis of statistical energy deposition probabilities for cellular level targets. It must also account fully for nonuniform distributions of sources in tissues, source-target geometries, and particle-track physics. 18 refs., 4 figs

  3. Beam emittance measurement from CERN thermionic guns

    International Nuclear Information System (INIS)

    Kester, O.; Rao, R.; Rinolfi, L.

    1992-01-01

    In the LEP Injector Linacs (LIL) a thermionic gun provides electron beams with different peak intensities at an energy of 80 keV. The beam emittances were estimated from the EGUN programme. Since the gun is of triode type, the main contribution to the emittance comes from the grid. The simulation programme does not model the real geometry by assuming a cylindrical symmetry, while the grid does not have such symmetry. A Gun Test Facility (GTF), allowing emittance measurements, based on the 3-gradients-method was installed. The experimental results are presented. (author) 6 refs.; 6 figs

  4. Beam diagnostics using an emittance measurement device

    International Nuclear Information System (INIS)

    Sarstedt, M.; Becker, R.; Klein, H.; Maaser, A.; Mueller, J.; Thomae, R.; Weber, M.

    1995-01-01

    For beam diagnostics aside from Faraday cups for current measurements and analysing magnets for the determination of beam composition and energy the most important tool is an emittance measurement device. With such a system the distribution of the beam particles in phase-space can be determined. This yields information not only on the position of the particles but also on their angle with respect to the beam axis. There are different kinds of emittance measurement devices using either circular holes or slits for separation of part of the beam. The second method (slit-slit measurement), though important for the determination of the rms-emittance, has the disadvantage of integrating over the y- and y'-coordinate (measurement in xx'-plane assumed). This leads to different emittance diagrams than point-point measurements, since in xx'-plane for each two corresponding points of rr'-plane there exists a connecting line. With regard to beam aberrations this makes xx'-emittances harder to interpret. In this paper the two kinds of emittance diagrams are discussed. Additionally the influence of the slit height on the xx'-emittance is considered. The analytical results are compared to experimental measurements in rr'-, rx'- and xx'-phase-space. (orig.)

  5. Radiation dosimetry in radiotherapy with internal emitters

    International Nuclear Information System (INIS)

    Stabin, Michael G.

    1997-01-01

    Full text. Radiation dosimetry radionuclides are currently being labeled to various biological agents used in internal emitter radiotherapy. This talk will review the various technologies and types of radiolabel in current use, with focus on the characterization of the radiation dose to the various important tissues of the body. Methods for obtaining data, developing kinetic models, and calculating radiation doses will be reviewed. Monoclonal antibodies are currently being labeled with both alpha and beta emitting radionuclides in attempts to find effective agents against cancer. Several radionuclides are also being used as bone pain palliation agents. These agents must be studied in clinical trials to determine the biokinetics and radiation dosimetry prior to approval for general use. In such studies, it is important to ensure the collection of the appropriate kinds of data and to collect the data at appropriate time intervals. The uptake and retention of activity in all significant source organs and in excreta be measured periodically (with at least 2 data points phase of uptake or clearance). Then, correct dosimetry methods must be applied - the best available methods for characterizing the radionuclide kinetic and for estimating the dosimetry in the various organs of the body especially the marrow, should be used. Attempts are also under way to develop methods for estimating true patient-specific dosimetry. Cellular and animal studies are also. Valuable in evaluating the efficacy of the agents in shrinking or eliminating tumors; some results from such studies will also be discussed. The estimation of radiation doses to patients in therapy with internal emitters involves several complex phases of analysis. Careful attention to detail and the use of the best available methods are essential to the protection of the patient and a successful outcome

  6. Auger electron emitter against multiple myeloma - targeted endo-radio-therapy with {sup 125}I-labeled thymidine analogue 5-iodo-4'-thio-2'-deoxyuridine

    Energy Technology Data Exchange (ETDEWEB)

    Morgenroth, Agnieszka, E-mail: amorgenroth@ukaachen.de [Nuclear Medicine Clinic, University Ulm, Albert-Einstein-Allee 23, D-89081 Ulm (Germany); Nuclear Medicine Clinic, University Aachen, RWTH, Pauwelsstrasse 30, D-52074 Aachen (Germany); Dinger, Cornelia; Zlatopolskiy, Boris D.; Al-Momani, Ehab; Glatting, Gerhard [Nuclear Medicine Clinic, University Ulm, Albert-Einstein-Allee 23, D-89081 Ulm (Germany); Mottaghy, Felix M. [Nuclear Medicine Clinic, University Aachen, RWTH, Pauwelsstrasse 30, D-52074 Aachen (Germany); Reske, Sven N. [Nuclear Medicine Clinic, University Ulm, Albert-Einstein-Allee 23, D-89081 Ulm (Germany)

    2011-10-15

    Introduction: Multiple myeloma (MM) is a plasma cell malignancy characterized by accumulation of malignant, terminally differentiated B cells in the bone marrow. Despite advances in therapy, MM remains an incurable disease. Novel therapeutic approaches are, therefore, urgently needed. Auger electron-emitting radiopharmaceuticals are attractive for targeted nano-irradiation therapy, given that DNA of malignant cells is selectively addressed. Here we evaluated the antimyeloma potential of the Auger electron-emitting thymidine analogue {sup 125}I-labeled 5-iodo-4'-thio-2'-deoxyuridine ([{sup 125}I]ITdU). Methods: Cellular uptake and DNA incorporation of [{sup 125}I]ITdU were determined in fluorodeoxyuridine-pretreated KMS12BM, U266, dexamethasone-sensitive MM1.S and -resistant MM1.R cell lines. The effect of stimulation with interleukin 6 (IL6) or insulin-like growth factor 1 (IGF1) on the intracellular incorporation of [{sup 125}I]ITdU was investigated in cytokine-sensitive MM1.S and MM1.R cell lines. Apoptotic cells were identified using Annexin V. Cleavage of caspase 3 and PARP was visualized by Western blot. DNA fragmentation was investigated using laddering assay. Therapeutic efficiency of [{sup 125}I]ITdU was proven by clonogenic assay. Results: [{sup 125}I]ITdU was shown to be efficiently incorporated into DNA of malignant cells, providing a promising mechanism for delivering highly toxic Auger radiation emitters into tumor DNA. [{sup 125}I]ITdU had a potent antimyeloma effect in cell lines representing distinct disease stages and, importantly, in cell lines sensitive or resistant to the conventional therapeutic agent, but was not toxic for normal plasma and bone marrow stromal cells. Furthermore, [{sup 125}I]ITdU abrogated the protective actions of IL6 and IGF1 on MM cells. [{sup 125}I]ITdU induced massive damage in the DNA of malignant plasma cells, which resulted in efficient inhibition of clonogenic growth. Conclusion: These studies may provide a

  7. Activities in the Dynamic Occupational Therapy Method

    Directory of Open Access Journals (Sweden)

    Jô Benetton

    2013-12-01

    Full Text Available This paper addresses the concept and use of the instrument named ‘activities’ in occupational therapy, sustained by the propositions of the Dynamic Occupational Therapy Method (DOTM. Initially, we present general aspects related to the activities in the DOTM such as the option for the name ‘activities’, its conceptual definition, use as a tool, and active participation in the dynamic of triadic relationship. Further, it approaches the character of activities: therapeutic, educational and social qualities, which distinguish this peculiar occupational therapy. Moreover, the paper highlights the use of activities as a tool, both as a central element of the processes that should underpin clinical reasoning (observation, information, association, setting up space of historicity, and construction of narrative, and as an element belonging to diagnostic procedures, to the course of clinical process, and to evaluation. Finally, we present our understanding of what we call resources in DOTM, and its intrinsic connection with the possibility of performing ‘activities’. For the creation of DOTM, occupational therapy, as a practice focused on the uniqueness of the case, was made the object of study in order to promote knowledge construction. The conceptual and instrumental framework presented in this work held this effort. We hope that this study could be useful for initial and continuing training in Occupational Therapy as well as for enriching the debate on the use of ‘activities’ in our profession.

  8. Development of Emittance Analysis Software for Ion Beam Characterization

    International Nuclear Information System (INIS)

    Padilla, M.J.; Liu, Yuan

    2007-01-01

    Transverse beam emittance is a crucial property of charged particle beams that describes their angular and spatial spread. It is a figure of merit frequently used to determine the quality of ion beams, the compatibility of an ion beam with a given beam transport system, and the ability to suppress neighboring isotopes at on-line mass separator facilities. Generally, a high-quality beam is characterized by a small emittance. In order to determine and improve the quality of ion beams used at the Holifield Radioactive Ion Beam Facility (HRIBF) for nuclear physics and nuclear astrophysics research, the emittances of the ion beams are measured at the off-line Ion Source Test Facilities. In this project, emittance analysis software was developed to perform various data processing tasks for noise reduction, to evaluate root-mean-square emittance, Twiss parameters, and area emittance of different beam fractions. The software also provides 2D and 3D graphical views of the emittance data, beam profiles, emittance contours, and RMS. Noise exclusion is essential for accurate determination of beam emittance values. A Self-Consistent, Unbiased Elliptical Exclusion (SCUBEEx) method is employed. Numerical data analysis techniques such as interpolation and nonlinear fitting are also incorporated into the software. The software will provide a simplified, fast tool for comprehensive emittance analysis. The main functions of the software package have been completed. In preliminary tests with experimental emittance data, the analysis results using the software were shown to be accurate

  9. DEVELOPMENT OF EMITTANCE ANALYSIS SOFTWARE FOR ION BEAM CHARACTERIZATION

    Energy Technology Data Exchange (ETDEWEB)

    Padilla, M. J.; Liu, Y.

    2007-01-01

    Transverse beam emittance is a crucial property of charged particle beams that describes their angular and spatial spread. It is a fi gure of merit frequently used to determine the quality of ion beams, the compatibility of an ion beam with a given beam transport system, and the ability to suppress neighboring isotopes at on-line mass separator facilities. Generally a high quality beam is characterized by a small emittance. In order to determine and improve the quality of ion beams used at the Holifi eld Radioactive Ion beam Facility (HRIBF) for nuclear physics and nuclear astrophysics research, the emittances of the ion beams are measured at the off-line Ion Source Test Facilities. In this project, emittance analysis software was developed to perform various data processing tasks for noise reduction, to evaluate root-mean-square emittance, Twiss parameters, and area emittance of different beam fractions. The software also provides 2D and 3D graphical views of the emittance data, beam profi les, emittance contours, and RMS. Noise exclusion is essential for accurate determination of beam emittance values. A Self-Consistent, Unbiased Elliptical Exclusion (SCUBEEx) method is employed. Numerical data analysis techniques such as interpolation and nonlinear fi tting are also incorporated into the software. The software will provide a simplifi ed, fast tool for comprehensive emittance analysis. The main functions of the software package have been completed. In preliminary tests with experimental emittance data, the analysis results using the software were shown to be accurate.

  10. Diabetic osteoarthropathy: modern methods of therapy

    Directory of Open Access Journals (Sweden)

    Irina Nikolaevna Ul'yanova

    2010-12-01

    Full Text Available This paper is focused on the main aspects of pathogenesis of diabetic osteoarthropathy (DOAP underlain by motor and sensory neuropathies, injuries(including microfractures and joint disintegration, and inflammation accompanied by enhanced cytokine expression. The role of osteopenia andbone resorption-formation decoupling at different stages of DOAP is discussed. Modern methods of DOAP treatment are considered with special referenceto immobilization, drug therapy, surgical and orthopedic care

  11. Cancer from internal emitters

    International Nuclear Information System (INIS)

    Boecker, B.B.; Griffith, W.C. Jr.

    1995-01-01

    Irradiation from internal emitters, or internally deposited radionuclides, is an important component of radiation exposures encountered in the workplace, home, or general environment. Long-term studies of human populations exposed to various internal emitters by different routes of exposure are producing critical information for the protection of workers and members of the general public. The purpose of this report is to examine recent developments and discuss their potential importance for understanding lifetime cancer risks from internal emitters. The major populations of persons being studied for lifetime health effects from internally deposited radionuclides are well known: Lung cancer in underground miners who inhaled Rn progeny, liver cancer from persons injected with the Th-containing radiographic contrast medium Thorotrast, bone cancer from occupational or medical intakes of 226 Ra or medical injections of 224 Ra, and thyroid cancer from exposures to iodine radionuclides in the environment or for medical purposes

  12. Low emittance photoinjectors

    International Nuclear Information System (INIS)

    Ferrario, Massimo

    2001-01-01

    Photon colliders require high charge polarized electron beams with very low normalized emittances, possibly lower than the actual damping rings design goals. Recent analytical and numerical efforts in understanding beam dynamics in RF photoinjectors have raised again the question as to whether the performances of an RF electron gun based injector could be competitive with respect to a damping ring. As a matter of discussion we report in this paper the most recent results concerning low emittance photoinjector designs: the production of polarized electron beams by DC and/or RF guns is illustrated together with space charge compensation techniques and thermal emittance effects. New ideas concerning multi-gun injection system and generation of flat beams by RF gun are also discussed

  13. FACET Emittance Growth

    Energy Technology Data Exchange (ETDEWEB)

    Frederico, J; Hogan, M.J.; Nosochkov, Y.; Litos, M.D.; Raubenheimer, T.; /SLAC

    2011-04-05

    FACET, the Facility for Advanced Accelerator and Experimental Tests, is a new facility being constructed in sector 20 of the SLAC linac primarily to study beam driven plasma wakefield acceleration. The FACET beamline consists of a chicane and final focus system to compress the 23 GeV, 3.2 nC electron bunches to {approx}20 {micro}m long and {approx}10 {micro}m wide. Simulations of the FACET beamline indicate the short-duration and large, 1.5% rms energy spread beams may suffer a factor of four emittance growth from a combination of chromaticity, incoherent synchrotron radiation (ISR), and coherent synchrotron radiation (CSR). Emittance growth is directly correlated to head erosion in plasma wakefield acceleration and is a limiting factor in single stage performance. Studies of the geometric, CSR, and ISR components are presented. Numerical calculation of the rms emittance can be overwhelmed by long tails in the simulated phase space distributions; more useful definitions of emittance are given. A complete simulation of the beamline is presented as well, which agrees with design specifications.

  14. FACET Emittance Growth

    International Nuclear Information System (INIS)

    Frederico, Joel

    2011-01-01

    FACET, the Facility for Advanced Accelerator and Experimental Tests, is a new facility being constructed in sector 20 of the SLAC linac primarily to study beam driven plasma wakefield acceleration. The FACET beamline consists of a chicane and final focus system to compress the 23 GeV, 3.2 nC electron bunches to ∼20 (micro)m long and ∼10 (micro)m wide. Simulations of the FACET beamline indicate the short-duration and large, 1.5% rms energy spread beams may suffer a factor of four emittance growth from a combination of chromaticity, incoherent synchrotron radiation (ISR), and coherent synchrotron radiation (CSR). Emittance growth is directly correlated to head erosion in plasma wakefield acceleration and is a limiting factor in single stage performance. Studies of the geometric, CSR, and ISR components are presented. Numerical calculation of the rms emittance can be overwhelmed by long tails in the simulated phase space distributions; more useful definitions of emittance are given. A complete simulation of the beamline is presented as well, which agrees with design specifications.

  15. Emittance calculations for the Stanford Linear Collider injector

    International Nuclear Information System (INIS)

    Sheppard, J.C.; Clendenin, J.E.; Helm, R.H.; Lee, M.J.; Miller, R.H.; Blocker, C.A.

    1983-03-01

    A series of measurements have been performed to determine the emittance of the high intensity, single bunch beam that is to be injected into the Stanford Linear Collider. On-line computer programs were used to control the Linac for the purpose of data acquisition and to fit the data to a model in order to deduce the beam emittance. This paper will describe the method of emittance calculation and present some of the measurement results

  16. Novel method to assessing and the impact of alpha emitter's concentration of the uterus on women fertility in Iraqi Kurdistan region

    International Nuclear Information System (INIS)

    Salih, N.F.; Jaafar, M.S.

    2013-01-01

    In the present work, 30 uterine tissue samples were collected from women with uterine problems from Iraqi Kurdistan. Tissue samples were analyzed and examined to measure levels of concentrated α-particle emitters and their short-lived decay products using a plastic track detector (CR-39) and the PVC long-tube technique with standard source radium ( 226 Ra). A new method and apparatus for the passive sampling of α-particles were also introduced. The maximum 0.0691 ppm and minimum 0.0180 ppm concentrations of particles were found in Sedakan and in Dukan, respectively; the average value was 0.0330 ppm, when compared the result with the result (0.12 ppm) in Asumadu-Sakyi et al. (Res J Environ Earth Sci 3(1):24-31, 2011) is lower than it and is agree with the result in Rubyie (Radioactive detection on the blood samples of cancer patients diseases by using CR-39 detector and its effect on cytogenetic. MSc. thesis, Al-Nahrain University, 2007). Also the results of fresh uterus are Significant (p 222 Rn gas varied from one woman to another depending on her age, the allergic reaction of her uterus to the radiation, and the geological formation of the area under study. The hazardous effects of α-particles are caused by increasing levels of ionizing radiation in the environment. (author)

  17. Rapid method of identification of {beta}-ray emitters and of {beta}-radioactive impurity dosage (1961); Methode rapide d'identification des emetteurs-{beta} et de dosage d'impuretes radioactives-{beta} (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Le Gallic, Y; Legrand, J; Grinberg, B [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-07-01

    We describe a simple method of radioactive analysis, which allows an accurate determination of maximal energies of {beta}-emitters, and detection and titration of radioactive impurities in radionuclides as well. The method described, which uses a plastic scintillator, is based on the fact that the curve obtained by plotting the number of pulses measured against the threshold is a straight line, in the case of pure {beta}-emitters. We then derive a simple relation between the data of this straight line and the maximal energy of the {beta}-spectrum of the radionuclide under consideration. (authors) [French] Description d'une methode simple d'analyse radioactive, permettant de determiner avec precision l'energie maximum des emetteurs-{beta}, ainsi que de deceler et de doser les impuretes radioactives dans un radionuclide. La technique decrite utilise un scintillateur plastique. On exploite le fait que la courbe du nombre d'impulsions mesurees, en fonction du seuil de discrimination, est une droite, pour un emetteur-{beta} pur. Une relation simple entre les caracteristiques de cette droite et l'energie maximum du spectre-{beta} du radionuclide, correspondant, a ete etablie. (auteurs)

  18. A new method to compare vehicle emissions measured by remote sensing and laboratory testing: high-emitters and potential implications for emission inventories.

    Science.gov (United States)

    Smit, Robin; Bluett, Jeff

    2011-06-01

    A new method is presented which is designed to investigate whether laboratory test data used in the development of vehicle emission models adequately reflects emission distributions, and in particular the influence of high-emitting vehicles. The method includes the computation of a 'high-emitter' or 'emission distribution' correction factor for use in emission inventories. In order to make a valid comparison we control for a number of factors such as vehicle technology, measurement technique and driving conditions and use a variable called 'Pollution Index' (g/kg). Our investigation into one vehicle class has shown that laboratory and remote sensing data are substantially different for CO, HC and NO(x) emissions, both in terms of their distributions as well as in their mean and 99-percentile values. Given that the remote sensing data has larger mean values for these pollutants, the analysis suggests that high-emitting vehicles may not be adequately captured in the laboratory test data. The paper presents two different methods for the computation of weighted correction factors for use in emission inventories based on laboratory test data: one using mean values for six 'power bins' and one using multivariate regression functions. The computed correction factors are substantial leading to an increase for laboratory-based emission factors with a factor of 1.7-1.9 for CO, 1.3-1.6 for HC and 1.4-1.7 for NO(x) (actual value depending on the method). However, it also clear that there are points that require further examination before these correction factors should be applied. One important step will be to include a comparison with other types of validation studies such as tunnel studies and near-road air quality assessments to examine if these correction factors are confirmed. If so, we would recommend using the correction factors in emission inventories for motor vehicles. Copyright © 2011 Elsevier B.V. All rights reserved.

  19. Quantitative single-particle digital autoradiography with α-particle emitters for targeted radionuclide therapy using the iQID camera.

    Science.gov (United States)

    Miller, Brian W; Frost, Sofia H L; Frayo, Shani L; Kenoyer, Aimee L; Santos, Erlinda; Jones, Jon C; Green, Damian J; Hamlin, Donald K; Wilbur, D Scott; Fisher, Darrell R; Orozco, Johnnie J; Press, Oliver W; Pagel, John M; Sandmaier, Brenda M

    2015-07-01

    Alpha-emitting radionuclides exhibit a potential advantage for cancer treatments because they release large amounts of ionizing energy over a few cell diameters (50-80 μm), causing localized, irreparable double-strand DNA breaks that lead to cell death. Radioimmunotherapy (RIT) approaches using monoclonal antibodies labeled with α emitters may thus inactivate targeted cells with minimal radiation damage to surrounding tissues. Tools are needed to visualize and quantify the radioactivity distribution and absorbed doses to targeted and nontargeted cells for accurate dosimetry of all treatment regimens utilizing α particles, including RIT and others (e.g., Ra-223), especially for organs and tumors with heterogeneous radionuclide distributions. The aim of this study was to evaluate and characterize a novel single-particle digital autoradiography imager, the ionizing-radiation quantum imaging detector (iQID) camera, for use in α-RIT experiments. The iQID camera is a scintillator-based radiation detection system that images and identifies charged-particle and gamma-ray/x-ray emissions spatially and temporally on an event-by-event basis. It employs CCD-CMOS cameras and high-performance computing hardware for real-time imaging and activity quantification of tissue sections, approaching cellular resolutions. In this work, the authors evaluated its characteristics for α-particle imaging, including measurements of intrinsic detector spatial resolutions and background count rates at various detector configurations and quantification of activity distributions. The technique was assessed for quantitative imaging of astatine-211 ((211)At) activity distributions in cryosections of murine and canine tissue samples. The highest spatial resolution was measured at ∼20 μm full width at half maximum and the α-particle background was measured at a rate as low as (2.6 ± 0.5) × 10(-4) cpm/cm(2) (40 mm diameter detector area). Simultaneous imaging of multiple tissue sections was

  20. Low-emittance Storage Rings

    CERN Document Server

    Wolski, Andrzej

    2014-01-01

    The effects of synchrotron radiation on particle motion in storage rings are discussed. In the absence of radiation, particle motion is symplectic, and the beam emittances are conserved. The inclusion of radiation effects in a classical approximation leads to emittance damping: expressions for the damping times are derived. Then, it is shown that quantum radiation effects lead to excitation of the beam emittances. General expressions for the equilibrium longitudinal and horizontal (natural) emittances are derived. The impact of lattice design on the natural emittance is discussed, with particular attention to the special cases of FODO-, achromat- and theoretical-minimum-emittance-style lattices. Finally, the effects of betatron coupling and vertical dispersion (generated by magnet alignment and lattice tuning errors) on the vertical emittance are considered.

  1. Rare Earth Garnet Selective Emitter

    Science.gov (United States)

    Lowe, Roland A.; Chubb, Donald L.; Farmer, Serene C.; Good, Brian S.

    1994-01-01

    Thin film Ho-YAG and Er-YAG emitters with a platinum substrate exhibit high spectral emittance in the emission band (epsilon(sub lambda) approx. = 0.75, sup 4)|(sub 15/2) - (sup 4)|(sub 13/2),for Er-YAG and epsilon(sub lambda) approx. = 0.65, (sup 5)|(sub 7) - (sup 5)|(sub 8) for Ho-YAG) at 1500 K. In addition, low out-of-band spectral emittance, epsilon(sub lambda) less than 0.2, suggest these materials would be excellent candidates for high efficiency selective emitters in thermophotovoltaic (TPV) systems operating at moderate temperatures (1200-1500 K). Spectral emittance measurements of the thin films were made (1.2 less than lambda less than 3.0 microns) and compared to the theoretical emittances calculated using measured values of the spectral extinction coefficient. In this paper we present the results for a new class of rare earth ion selective emitters. These emitters are thin sections (less than 1 mm) of yttrium aluminum garnet (YAG) single crystal with a rare earth substitutional impurity. Selective emitters in the near IR are of special interest for thermophotovoltaic (TPV) energy conversion. The most promising solid selective emitters for use in a TPV system are rare earth oxides. Early spectral emittance work on rare earth oxides showed strong emission bands in the infrared (0.9 - 3 microns). However, the emittance outside the emission band was also significant and the efficiency of these emitters was low. Recent improvements in efficiency have been made with emitters fabricated from fine (5 - 10 microns) rare earth oxide fibers similar to the Welsbach mantle used in gas lanterns. However, the rare earth garnet emitters are more rugged than the mantle type emitters. A thin film selective emitter on a low emissivity substrate such as gold, platinum etc., is rugged and easily adapted to a wide variety of thermal sources. The garnet structure and its many subgroups have been successfully used as hosts for rare earth ions, introduced as substitutional

  2. Dosimetry of internal emitters

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    The Dosimetry of Internal Emitter Program endeavors to refine the correlation between radiation dose and observed biological effects. The program is presently engaged in the development of studies that will demonstrate the applicability of microdosimetry models developed under the Microdosimetry of Internal Sources Program. The program also provides guidance and assistance to Pacific Northwest Laboratory's Biology Department in the dosimetric analysis of internally deposited radionuclides. This report deals with alpha particle dosimetry plutonium 239 inhalation, and in vitro studies of chromosomal observations

  3. Nonintercepting emittance monitor

    International Nuclear Information System (INIS)

    Miller, R.H.; Clendenin, J.E.; James, M.B.; Sheppard, J.C.

    1983-08-01

    A nonintercepting emittance monitor is a helpful device for measuring and improving particle beams in accelerators and storage rings as it allows continuous monitoring of the beam's distribution in phase space, and perhaps closed loop computer control of the distributions. Stripline position monitors are being investigated for use as nonintercepting emittance monitors for a beam focused by a FODO array in the first 100 meters of our linear accelerator. The technique described here uses the signal from the four stripline probes of a single position monitor to measure the quadrupole mode of the wall current in the beam pipe. This current is a function of the quadrupole moment of the beam, sigma 2 /sub x/ - sigma 2 /sub y/. In general, six independent measurements of the quadrupole moment are necessary to determine the beam emittance. This technique is dependent on the characteristically large variations of sigma 2 /sub x/ - sigma 2 /sub y/ in a FODO array. It will not work in a focusing system where the beam is round at each focusing element

  4. Some method for teaching physics to residents in radiation therapy

    International Nuclear Information System (INIS)

    Hughes, D.B.

    A method is presented for teaching physics to residents in radiation therapy. Some of the various responsabilities of a hospital physicist are listed, with particular reference to radiation therapy departments [pt

  5. Monolithic multinozzle emitters for nanoelectrospray mass spectrometry

    Science.gov (United States)

    Wang, Daojing [Daly City, CA; Yang, Peidong [Kensington, CA; Kim, Woong [Seoul, KR; Fan, Rong [Pasadena, CA

    2011-09-20

    Novel and significantly simplified procedures for fabrication of fully integrated nanoelectrospray emitters have been described. For nanofabricated monolithic multinozzle emitters (NM.sup.2 emitters), a bottom up approach using silicon nanowires on a silicon sliver is used. For microfabricated monolithic multinozzle emitters (M.sup.3 emitters), a top down approach using MEMS techniques on silicon wafers is used. The emitters have performance comparable to that of commercially-available silica capillary emitters for nanoelectrospray mass spectrometry.

  6. Laser therapy and comparative therapy methods in parodontology

    International Nuclear Information System (INIS)

    Schauer, P

    1997-02-01

    This two studies aim to examine application of a diode-laser in periodontal therapy. The aim of the pilot-study was to examine the immediate effect of the diode-laser in reducing the bacterial concentration in periodontal pockets. 50 patients were randomly subdivided into two groups (laser group, control group) and microbiologic samples were collected. One week after the therapy (1 st group: scaling and laser, 2 nd group: scaling) there were taken further more samples from the same periodontal pockets treated before. The microbiologic samples were evaluated to verify bacterial elimination from the periodontal pockets, especially Actinobacillus actinomycetemcomitans could be considerably eliminated from periodontal pockets by the diode laser. In the long-term study, there were two groups, one laser-group and one control-group. All 50 patients were required to have periodontal pockets with a minimum depth of 4 mm in each quadrate. The bacterial reduction, the change of bleeding on probing and the pocket depth had been evaluated six months after therapy. The irradiation with the diode laser allows considerable bacterial elimination, the index of bleeding on probing came out to be significantly better than in the control group. The reduction of pocket depth was also greater than in the control group. (author)

  7. Evaluation of dual energy quantitative CT for determining the spatial distributions of red marrow and bone for dosimetry in internal emitter radiation therapy

    International Nuclear Information System (INIS)

    Goodsitt, Mitchell M.; Shenoy, Apeksha; Howard, David; Christodoulou, Emmanuel; Dewaraja, Yuni K.; Shen, Jincheng; Schipper, Matthew J.; Wilderman, Scott; Chun, Se Young

    2014-01-01

    Purpose: To evaluate a three-equation three-unknown dual-energy quantitative CT (DEQCT) technique for determining region specific variations in bone spongiosa composition for improved red marrow dose estimation in radionuclide therapy. Methods: The DEQCT method was applied to 80/140 kVp images of patient-simulating lumbar sectional body phantoms of three sizes (small, medium, and large). External calibration rods of bone, red marrow, and fat-simulating materials were placed beneath the body phantoms. Similar internal calibration inserts were placed at vertebral locations within the body phantoms. Six test inserts of known volume fractions of bone, fat, and red marrow were also scanned. External-to-internal calibration correction factors were derived. The effects of body phantom size, radiation dose, spongiosa region segmentation granularity [single (∼17 × 17 mm) region of interest (ROI), 2 × 2, and 3 × 3 segmentation of that single ROI], and calibration method on the accuracy of the calculated volume fractions of red marrow (cellularity) and trabecular bone were evaluated. Results: For standard low dose DEQCT x-ray technique factors and the internal calibration method, the RMS errors of the estimated volume fractions of red marrow of the test inserts were 1.2–1.3 times greater in the medium body than in the small body phantom and 1.3–1.5 times greater in the large body than in the small body phantom. RMS errors of the calculated volume fractions of red marrow within 2 × 2 segmented subregions of the ROIs were 1.6–1.9 times greater than for no segmentation, and RMS errors for 3 × 3 segmented subregions were 2.3–2.7 times greater than those for no segmentation. Increasing the dose by a factor of 2 reduced the RMS errors of all constituent volume fractions by an average factor of 1.40 ± 0.29 for all segmentation schemes and body phantom sizes; increasing the dose by a factor of 4 reduced those RMS errors by an average factor of 1.71 ± 0.25. Results

  8. Molecular methods in nuclear medicine therapy

    International Nuclear Information System (INIS)

    Lee, Kyung Han

    2001-01-01

    Nuclear medicine has traditionally contributed to molecular oncology by allowing noninvasive monitoring of tumor metabolism, growth and genetic changes, thereby providing a basis for appropriate biology-based treatment planning. However, NM techniques are now being applied as an active therapeutic tool in novel molecular approaches for cancer treatment. Such areas include research on cancer therapy with radiolabeled ligands or oligonucleotides, and utilization of synergism between NM radiotherapy and gene transfer techniques. Here we will focus on novel aspects of nuclear medicine therapy

  9. Emittance growth in rf linacs

    International Nuclear Information System (INIS)

    Jameson, R.A.

    1979-01-01

    As the space-charge limit is approached, the current that can be accelerated in an rf linac and the output emittance that can be expected are discussed. The role of the envelope equations to estimate limits is outlined. The results of numerical experiments to explore general properties of emittance growth are given

  10. Beam phase space and emittance

    International Nuclear Information System (INIS)

    Buon, J.

    1990-12-01

    The classical and elementary results for canonical phase space, the Liouville theorem and the beam emittance are reviewed. Then, the importance of phase portraits to obtain a geometrical description of motion is emphasized, with examples in accelerator physics. Finally, a statistical point of view is used to define beam emittance, to study its law of approximate conservation and to treat two particular examples

  11. Using mixed methods in music therapy health care research

    DEFF Research Database (Denmark)

    Bonde, Lars Ole

    2015-01-01

    »Mixed methods« (or »multiple methods») is a fairly new concept in music therapy research. It is inspired by recent methodological developments in social science, covering the interaction of quantitative and qualitative methods in one and the same research study. Mixed methods are not the same...... as the diversity or pluralism of methods advocated by many scholars who are critical towards the principles of evidence-based medicine. This article presents a concrete example of mixed methods in music therapy research: a psycho-social study of music therapy with female cancer survivors. Problems related...

  12. Theory and measurements of emittance preservation in plasma wakefield acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Frederico, Joel

    2016-12-01

    In this dissertation, we examine the preservation and measurement of emittance in the plasma wakefield acceleration blowout regime. Plasma wakefield acceleration (PWFA) is a revolutionary approach to accelerating charged particles that has been demonstrated to have the potential for gradients orders of magnitude greater than traditional approaches. The application of PWFA to the design of a linear collider will make new high energy physics research possible, but the design parameters must first be shown to be competitive with traditional methods. Emittance preservation is necessary in the design of a linear collider in order to maximize luminosity. We examine the conditions necessary for circular symmetry in the PWFA blowout regime, and demonstrate that current proposals meet these bounds. We also present an application of beam lamentation which describes the process of beam parameter and emittance matching. We show that the emittance growth saturates as a consequence of energy spread in the beam. The initial beam parameters determine the amount of emittance growth, while the contribution of energy spread is negligible. We also present a model for ion motion in the presence of a beam that is much more dense than the plasma. By combining the model of ion motion and emittance growth, we find the emittance growth due to ion motion is minimal in the case of marginal ion motion. In addition, we present a simulation that validates the ion motion model, which is under further development to examine emittance growth of both marginal and pronounced ion motion. Finally, we present a proof-of-concept of an emittance measurement which may enable the analysis of emittance preservation in future PWFA experiments.

  13. Remote detection of single emitters via optical waveguides

    Science.gov (United States)

    Then, Patrick; Razinskas, Gary; Feichtner, Thorsten; Haas, Philippe; Wild, Andreas; Bellini, Nicola; Osellame, Roberto; Cerullo, Giulio; Hecht, Bert

    2014-05-01

    The integration of lab-on-a-chip technologies with single-molecule detection techniques may enable new applications in analytical chemistry, biotechnology, and medicine. We describe a method based on the reciprocity theorem of electromagnetic theory to determine and optimize the detection efficiency of photons emitted by single quantum emitters through truncated dielectric waveguides of arbitrary shape positioned in their proximity. We demonstrate experimentally that detection of single quantum emitters via such waveguides is possible, confirming the predicted behavior of the detection efficiency. Our findings blaze the trail towards efficient lensless single-emitter detection compatible with large-scale optofluidic integration.

  14. Alternative Therapy of Animals – Homeopathy and Other Alternative Methods of Therapy

    Directory of Open Access Journals (Sweden)

    Løken Torleiv

    2002-03-01

    Full Text Available Alternative therapy of animals is described, in the meaning of alternatives to veterinary therapy traditionally accepted by veterinary faculties and schools and included in their curricula. Alternative therapy composes of different disciplines, of which homeopathy is emphasised in this presentation. Information is given on the use and interest of such therapy among veterinarians and animal owners. Homeopathy as other alternative therapies, may offer great advances, if they induce any effect. Some of the disciplines are based on a scientifically accepted documentation. Others, and homeopathy in particular, are missing such a documentation of effect. The justification of including alternative therapy in treating animals is discussed. Research in alternative therapy of animals is greatly needed, in particular to evaluate therapeutic methods which are in extensive use without any documented effect. An ongoing research project in Norway on the effect of homeopathic treatment of mastitis in cows is shortly presented.

  15. Electrohydrodynamic emitters of ion beams

    International Nuclear Information System (INIS)

    Dudnikov, V.G.; Shabalin, A.L.

    1990-01-01

    Physical processes determining generation of ion beams with high emission current density in electrohydrodynamic emitters are considered. Electrohydrodynamic effects developing in ion emission features and kinetics of ion interaction in beams with high density are discussed. Factors determining the size of the emission zone, emission stability at high and low currents, cluster generation, increase of energy spread and decrease of brightness are analyzed. Problems on practical provision of stable EHD emitter functioning are considered. 94 refs.; 8 figs.; 1 tab

  16. Diamondoid monolayers as electron emitters

    Science.gov (United States)

    Yang, Wanli [El Cerrito, CA; Fabbri, Jason D [San Francisco, CA; Melosh, Nicholas A [Menlo Park, CA; Hussain, Zahid [Orinda, CA; Shen, Zhi-Xun [Stanford, CA

    2012-04-10

    Provided are electron emitters based upon diamondoid monolayers, preferably self-assembled higher diamondoid monolayers. High intensity electron emission has been demonstrated employing such diamondoid monolayers, particularly when the monolayers are comprised of higher diamondoids. The application of such diamondoid monolayers can alter the band structure of substrates, as well as emit monochromatic electrons, and the high intensity electron emissions can also greatly improve the efficiency of field-effect electron emitters as applied to industrial and commercial applications.

  17. Nanodiamond Emitters of Single Photons

    Directory of Open Access Journals (Sweden)

    Vlasov I.I.

    2015-01-01

    Full Text Available Luminescence properties of single color centers were studied in nanodiamonds of different origin. It was found that single photon emitters could be realized even in molecularsized diamond (less than 2 nm capable of housing stable luminescent center “silicon-vacancy.” First results on incorporation of single-photon emitters based on luminescent nanodiamonds in plasmonic nanoantennas to enhance the photon count rate and directionality, diminish the fluorescence decay time, and provide polarization selectivity are presented.

  18. A device for electron gun emittance measurement

    International Nuclear Information System (INIS)

    Aune, B.; Corveller, P.; Jablonka, M.; Joly, J.M.

    1985-05-01

    In order to improve the final emittance of the beam delivered by the ALS electron linac a new gun is going to be installed. To measure its emittance and evaluate the contribution of different factors to emittance growth we have developed an emittance measurement device. We describe the experimental and mathematical procedure we have followed, and give some results of measurements

  19. Method of radiation therapy treatment planning

    International Nuclear Information System (INIS)

    Hodes, L.

    1976-01-01

    A technique of radiation therapy treatment planning designed to allow the assignment of dosage limits directly to chosen points in the computer-displayed cross-section of the patient. These dosage limits are used as constraints in a linear programming attempt to solve for beam strengths, minimizing integral dosage. If a feasible plan exists, the optimized plan will be displayed for approval as an isodose pattern. If there is no feasible plan, the operator/therapist can designate some of the point dosage constraints as ''relaxed.'' Linear programming will then optimize for minimum deviation at the relaxed points. This process can be iterated and new points selected until an acceptable plan is realized. In this manner the plan is optimized for uniformity as well as overall low dosage. 6 claims, 6 drawing figures

  20. Transverse emittance measurement at REGAE via a solenoid scan

    Energy Technology Data Exchange (ETDEWEB)

    Hachmann, Max; Mayet, Frank; Gruener, Florian [Institut fuer Experimentalphysik, Universitaet Hamburg (Germany); Floettmann, Klaus [DESY, Hamburg (Germany)

    2013-07-01

    The linear accelerator REGAE at DESY produces short and low charged electron bunches, on the one hand to resolve the excitation transitions of atoms temporally by pump probe electron diffraction experiments and on the other hand to investigate principal mechanisms of laser plasma acceleration. For both cases a high quality electron beam is required which can be identified with a small beam emittance. The current method to measure the transverse beam emittance at REGAE and results are presented.

  1. Computing Eigen-Emittances from Tracking Data

    Energy Technology Data Exchange (ETDEWEB)

    Alexahin, Y. [Fermilab

    2014-09-18

    In a strongly nonlinear system the particle distribution in the phase space may develop long tails which contribution to the covariance (sigma) matrix should be suppressed for a correct estimate of the beam emittance. A method is offered based on Gaussian approximation of the original particle distribution in the phase space (Klimontovich distribution) which leads to an equation for the sigma matrix which provides efficient suppression of the tails and cannot be obtained by introducing weights. This equation is easily solved by iterations in the multi-dimensional case. It is also shown how the eigen-emittances and coupled optics functions can be retrieved from the sigma matrix in a strongly coupled system. Finally, the developed algorithm is applied to 6D ionization cooling of muons in HFOFO channel.

  2. Methods for Stem Cell Production and Therapy

    Science.gov (United States)

    Valluri, Jagan V. (Inventor); Claudio, Pier Paolo (Inventor)

    2015-01-01

    The present invention relates to methods for rapidly expanding a stem cell population with or without culture supplements in simulated microgravity conditions. The present invention relates to methods for rapidly increasing the life span of stem cell populations without culture supplements in simulated microgravity conditions. The present invention also relates to methods for increasing the sensitivity of cancer stem cells to chemotherapeutic agents by culturing the cancer stem cells under microgravity conditions and in the presence of omega-3 fatty acids. The methods of the present invention can also be used to proliferate cancer cells by culturing them in the presence of omega-3 fatty acids. The present invention also relates to methods for testing the sensitivity of cancer cells and cancer stem cells to chemotherapeutic agents by culturing the cancer cells and cancer stem cells under microgravity conditions. The methods of the present invention can also be used to produce tissue for use in transplantation by culturing stem cells or cancer stem cells under microgravity conditions. The methods of the present invention can also be used to produce cellular factors and growth factors by culturing stem cells or cancer stem cells under microgravity conditions. The methods of the present invention can also be used to produce cellular factors and growth factors to promote differentiation of cancer stem cells under microgravity conditions.

  3. Music therapy CD creation for initial pediatric radiation therapy: a mixed methods analysis.

    Science.gov (United States)

    Barry, Philippa; O'Callaghan, Clare; Wheeler, Greg; Grocke, Denise

    2010-01-01

    A mixed methods research design was used to investigate the effects of a music therapy CD (MTCD) creation intervention on pediatric oncology patients' distress and coping during their first radiation therapy treatment. The music therapy method involved children creating a music CD using interactive computer-based music software, which was "remixed" by the music therapist-researcher to extend the musical material. Eleven pediatric radiation therapy outpatients aged 6 to 13 years were randomly assigned to either an experimental group, in which they could create a music CD prior to their initial treatment to listen to during radiation therapy, or to a standard care group. Quantitative and qualitative analyses generated multiple perceptions from the pediatric patients, parents, radiation therapy staff, and music therapist-researcher. Ratings of distress during initial radiation therapy treatment were low for all children. The comparison between the two groups found that 67% of the children in the standard care group used social withdrawal as a coping strategy, compared to 0% of the children in the music therapy group; this trend approached significance (p = 0.076). MTCD creation was a fun, engaging, and developmentally appropriate intervention for pediatric patients, which offered a positive experience and aided their use of effective coping strategies to meet the demands of their initial radiation therapy treatment.

  4. Transverse Emittance Measurement and Preservation at the LHC

    CERN Document Server

    AUTHOR|(CDS)2082907

    The Large Hadron Collider (LHC) at CERN is a high energy storage ring that provides proton and heavy ion collisions to study fundamental particle physics. The luminosity production is closely linked to emittance preservation in the accelerator. The transverse emittance is the phase space density of the beam and should be conserved when the particle beam is transformed through the accelerator. Perturbing effects, however, can lead to emittance increase and hence luminosity degradation. Measuring the emittance growth is a complex task with high intensity beams and changing energies. The machine optics and the transverse beam size have to be measured as accurately as possible. Beta function measurements with k-modulation will be discussed. With this method the quadrupole focussing strength is varied and the resulting tune change is traced to determine the beta function at the quadrupole. A new k-modulation measurement tool was developed for the LHC. The fully automatic and online measurement system takes constra...

  5. Beam dynamics in rf guns and emittance correction techniques

    International Nuclear Information System (INIS)

    Serafini, L.

    1994-01-01

    In this paper we present a general review of beam dynamics in a laser-driven rf gun. The peculiarity of such an accelerating structure versus other conventional multi-cell linac structures is underlined on the basis of the Panofsky-Wenzel theorem, which is found to give a theoretical background for the well known Kim's model. A basic explanation for some proposed methods to correct rf induced emittance growth is also derived from the theorem. We also present three emittance correction techniques for the recovery of space-charge induced emittance growth, namely the optimum distributed disk-like bunch technique, the use of rf spatial harmonics to correct spherical aberration induced by space charge forces and the technique of emittance filtering by clipping the electron beam. The expected performances regarding the beam quality achievable with different techniques, as predicted by scaling laws and simulations, are analyzed, and, where available, compared to experimental results. (orig.)

  6. Therapy Decision Support Based on Recommender System Methods.

    Science.gov (United States)

    Gräßer, Felix; Beckert, Stefanie; Küster, Denise; Schmitt, Jochen; Abraham, Susanne; Malberg, Hagen; Zaunseder, Sebastian

    2017-01-01

    We present a system for data-driven therapy decision support based on techniques from the field of recommender systems. Two methods for therapy recommendation, namely, Collaborative Recommender and Demographic-based Recommender , are proposed. Both algorithms aim to predict the individual response to different therapy options using diverse patient data and recommend the therapy which is assumed to provide the best outcome for a specific patient and time, that is, consultation. The proposed methods are evaluated using a clinical database incorporating patients suffering from the autoimmune skin disease psoriasis. The Collaborative Recommender proves to generate both better outcome predictions and recommendation quality. However, due to sparsity in the data, this approach cannot provide recommendations for the entire database. In contrast, the Demographic-based Recommender performs worse on average but covers more consultations. Consequently, both methods profit from a combination into an overall recommender system.

  7. Therapy Decision Support Based on Recommender System Methods

    Directory of Open Access Journals (Sweden)

    Felix Gräßer

    2017-01-01

    Full Text Available We present a system for data-driven therapy decision support based on techniques from the field of recommender systems. Two methods for therapy recommendation, namely, Collaborative Recommender and Demographic-based Recommender, are proposed. Both algorithms aim to predict the individual response to different therapy options using diverse patient data and recommend the therapy which is assumed to provide the best outcome for a specific patient and time, that is, consultation. The proposed methods are evaluated using a clinical database incorporating patients suffering from the autoimmune skin disease psoriasis. The Collaborative Recommender proves to generate both better outcome predictions and recommendation quality. However, due to sparsity in the data, this approach cannot provide recommendations for the entire database. In contrast, the Demographic-based Recommender performs worse on average but covers more consultations. Consequently, both methods profit from a combination into an overall recommender system.

  8. Dosimetry methods in boron neutron capture therapy

    Energy Technology Data Exchange (ETDEWEB)

    Gambarini, G.; Artuso, E.; Felisi, M.; Regazzoni, V.; Giove, D. [Universita degli Studi di Milano, Department of Physics, Via Festa del Patrono 7, 20122 Milano (Italy); Agosteo, S.; Barcaglioni, L. [Istituto Nazionale di Fisica Nucleare, Milano (Italy); Campi, F.; Garlati, L. [Politecnico di Milano, Energy Department, Piazza Leonardo Da Vinci 32, 20133 Milano (Italy); De Errico, F. [Universita degli Studi di Pisa, Department of Civil and Industrial Engineering, Lungamo Pacinotti 43, 56126 Pisa (Italy); Borroni, M.; Carrara, M. [Fondazione IRCCS Istituto Nazionale Tumori, Medical Physics Unit, Via Venezian 1, 20133 Milano (Italy); Burian, J.; Klupak, V.; Viererbl, L.; Marek, M. [Research Centre Rez, Department of Neutron Physics, 250-68 Husinec-Rez (Czech Republic)

    2014-08-15

    Dosimetry studies have been carried out at thermal and epithermal columns of Lvr-15 research reactor for investigating the spatial distribution of gamma dose, fast neutron dose and thermal neutron fluence. Two different dosimetry methods, both based on solid state detectors, have been studied and applied and the accuracy and consistency of the results have been inspected. One method is based on Fricke gel dosimeters that are dilute water solutions and have good tissue equivalence for neutrons and also for all the secondary radiations produced by neutron interactions in tissue or water phantoms. Fricke gel dosimeters give the possibility of separating the various dose contributions, i.e. the gamma dose, the fast neutron dose and the dose due to charged particles generated during thermal neutron reactions by isotopes having high cross section, like 10-B. From this last dose, thermal neutron fluence can be obtained by means of the kerma factor. The second method is based on thermoluminescence dosimeters. In particular, the developed method draw advantage from the different heights of the peaks of the glow curve of such phosphors when irradiated with photons or with thermal neutrons. The results show that satisfactory results can be obtained with simple methods, in spite of the complexity of the subject. However, the more suitable dosimeters and principally their utilization and analysis modalities are different for the various neutron beams, mainly depending on the relative intensities of the three components of the neutron field, in particular are different for thermal and epithermal columns. (Author)

  9. Dosimetry methods in boron neutron capture therapy

    International Nuclear Information System (INIS)

    Gambarini, G.; Artuso, E.; Felisi, M.; Regazzoni, V.; Giove, D.; Agosteo, S.; Barcaglioni, L.; Campi, F.; Garlati, L.; De Errico, F.; Borroni, M.; Carrara, M.; Burian, J.; Klupak, V.; Viererbl, L.; Marek, M.

    2014-08-01

    Dosimetry studies have been carried out at thermal and epithermal columns of Lvr-15 research reactor for investigating the spatial distribution of gamma dose, fast neutron dose and thermal neutron fluence. Two different dosimetry methods, both based on solid state detectors, have been studied and applied and the accuracy and consistency of the results have been inspected. One method is based on Fricke gel dosimeters that are dilute water solutions and have good tissue equivalence for neutrons and also for all the secondary radiations produced by neutron interactions in tissue or water phantoms. Fricke gel dosimeters give the possibility of separating the various dose contributions, i.e. the gamma dose, the fast neutron dose and the dose due to charged particles generated during thermal neutron reactions by isotopes having high cross section, like 10-B. From this last dose, thermal neutron fluence can be obtained by means of the kerma factor. The second method is based on thermoluminescence dosimeters. In particular, the developed method draw advantage from the different heights of the peaks of the glow curve of such phosphors when irradiated with photons or with thermal neutrons. The results show that satisfactory results can be obtained with simple methods, in spite of the complexity of the subject. However, the more suitable dosimeters and principally their utilization and analysis modalities are different for the various neutron beams, mainly depending on the relative intensities of the three components of the neutron field, in particular are different for thermal and epithermal columns. (Author)

  10. Modular low-voltage electron emitters

    International Nuclear Information System (INIS)

    Berejka, Anthony J.

    2005-01-01

    Modular, low-voltage electron emitters simplify electron beam (EB) technology for many industrial uses and for research and development. Modular electron emitters are produced in quantity as sealed systems that are evacuated at the factory, eliminating the need for vacuum pumps at the point of use. A plug-out-plug-in method of replacement facilitates servicing. By using an ultra-thin 6-7 μm titanium foil window, solid-state power supplies, an innovative design to extract and spread the beam (enabling systems to be placed adjacent to each other to extend beam width) and touch-screen computer controls, these modular units combine ease of use and electrical transfer efficiency at voltages that can be varied between 80 kV and 150 kV with beam currents up to 40 mA per 25 cm across the beam window. These new devices have been made in three widths: 5 cm, 25 cm, and 40 cm. Details of the beam construction and illustrations of industrial uses will be presented. Traditional uses in the graphic arts and coatings areas have welcomed this modular technology as well as uses for surface sterilization. Being compact and lightweight (∼15 kg/emitter), these modular beams have been configured around complex shapes to achieve three-dimensional surface curing at high production rates

  11. Modular low-voltage electron emitters

    Science.gov (United States)

    Berejka, Anthony J.

    2005-12-01

    Modular, low-voltage electron emitters simplify electron beam (EB) technology for many industrial uses and for research and development. Modular electron emitters are produced in quantity as sealed systems that are evacuated at the factory, eliminating the need for vacuum pumps at the point of use. A plug-out-plug-in method of replacement facilitates servicing. By using an ultra-thin 6-7 μm titanium foil window, solid-state power supplies, an innovative design to extract and spread the beam (enabling systems to be placed adjacent to each other to extend beam width) and touch-screen computer controls, these modular units combine ease of use and electrical transfer efficiency at voltages that can be varied between 80 kV and 150 kV with beam currents up to 40 mA per 25 cm across the beam window. These new devices have been made in three widths: 5 cm, 25 cm, and 40 cm. Details of the beam construction and illustrations of industrial uses will be presented. Traditional uses in the graphic arts and coatings areas have welcomed this modular technology as well as uses for surface sterilization. Being compact and lightweight (∼15 kg/emitter), these modular beams have been configured around complex shapes to achieve three-dimensional surface curing at high production rates.

  12. Application of the 4 {sup {pi}{sup {gamma}}} Method to the Absolute Standardization of Radioactive Sources of Positron Emitters; Aplicacion del Metodo 4 {sup {pi}{sup {gamma}}} a la Medida Absoluta de la Actividad de Fuentes Radiactivas Emisoras de Positrones

    Energy Technology Data Exchange (ETDEWEB)

    Peyres Medina, V.; Garcia-Torano Martinez, E.; Roteta Ibarra, M.

    2006-07-01

    We discuss the application of the method known as 4 {sup {pi}{sup {gamma}}} counting to the standardization of positron emitters. Monte Carlo simulations are used to calculate the detection efficiency of positrons emitted by the nuclides 22Na and 18F. Two experimental setups are used, both based on a NaI(Tl) well detector. The results of the standardizations are in good agreement with those obtained by other methods. It is shown that the 4 {sup {pi}{sup {gamma}}} method can be successfully used for the absolute standardization of sources of positron emitters. (Author) 23 refs.

  13. Radiation emitter-detector package

    International Nuclear Information System (INIS)

    O'Brien, J.T.; Limm, A.C.; Nyul, P.; Tassia, V.S. Jr.

    1978-01-01

    Mounted on the metallic base of a radiation emitter-detector is a mounting block is a first projection, and a second projection. A radiation detector is on the first projection and a semiconductor electroluminescent device, i.e., a radiation emitter, is on the second projection such that the plane of the recombination region of the electroluminescent device is perpendicular to the radiation incident surface of the radiation detector. The electroluminescent device has a primary emission and a secondary emission in a direction different from the primary emission. A radiation emitter-detector package as described is ideally suited to those applications wherein the secondary radiation of the electroluminescent device is fed into a feedback circuit regulating the biasing current of the electroluminescent device

  14. Advanced methods in diagnosis and therapy

    International Nuclear Information System (INIS)

    1987-01-01

    This important meeting covers the following topics: use and optimization of monoclonal antibobies in oncology: - Tumor markers: Clinical follow-up of patients through tumor marker serum determinations. - Cancer and medical imaging: The use of monoclonal antibodies in immunoscintigraphy. - Immunoradiotherapy: Monoclonal antibodies as therapeutic vectors. Advanced methods in diagnosis: - Contribution of monoclonal antibodies in modern immunochemistry (RIA, EIA). - Interest of monoclonal antibody in immunohistochemical pathology diagnosis. - In vitro diagnosis future prospects: with receptors and oncogenes. - Immunofluoroassay: a new sensitive immunoanalytical procedure with broad applications. Recent advances in brachitherapy: - Interest of computer processing. Blood products irradiation: - Interest in transfusion and bone marrow transplantations [fr

  15. Beam phase space and emittance

    International Nuclear Information System (INIS)

    Buon, J.

    1992-02-01

    The classical and elementary results for canonical phase space, the Liouville theorem and the beam emittance are reviewed. Then, the importance of phase portraits to obtain a geometrical description of motion is emphasized, with examples in accelerator physics. Finally, a statistical point of view is used to define beam emittance, to study its law of approximate conservation, with three particular examples, and to introduce a beam envelope-ellipse and the β-function, emphasing the statistical features of its properties. (author) 14 refs.; 11 figs

  16. Combustion powered thermophotovoltaic emitter system

    Energy Technology Data Exchange (ETDEWEB)

    McHenry, R.S. [Naval Academy, Annapolis, MD (United States). Naval Architecture, Ocean and Marine Engineering

    1995-07-01

    The US Naval Academy (USNA) has recently completed an engineering design project for a high temperature thermophotovoltaic (TPV) photon emitter. The final apparatus was to be portable, completely self contained, and was to incorporate cycle efficiency optimization such as exhaust stream recuperation. Through computer modeling and prototype experimentation, a methane fueled emitter system was designed from structural ceramic materials to fulfill the high temperature requirements necessary for high system efficiency. This paper outlines the engineering design process, discusses obstacles and solutions encountered, and presents the final design.

  17. Electromagnetic compatibility of implantable neurostimulators to RFID emitters

    Directory of Open Access Journals (Sweden)

    Guag Joshua W

    2011-06-01

    Full Text Available Abstract Background The objective of this study is to investigate electromagnetic compatibility (EMC of implantable neurostimulators with the emissions from radio frequency identification (RFID emitters. Methods Six active implantable neurostimulators with lead systems were tested for susceptibility to electromagnetic fields generated by 22 RFID emitters. These medical devices have been approved for marketing in the U.S. for a number of intended uses that include: epilepsy, depression, incontinence, Parkinsonian tremor and pain relief. Each RFID emitter had one of the following carrier frequencies: 125 kHz, 134 kHz, 13.56 MHz, 433 MHz, 915 MHz and 2.45 GHz Results The test results showed the output of one of the implantable neurostimulators was inhibited by 134 kHz RFID emitter at separation distances of 10 cm or less. The output of the same implantable neurostimulator was also inhibited by another 134 kHz RFID emitter at separation distances of 10 cm or less and also showed inconsistent pulsing rate at a separation distance of 15 cm. Both effects occurred during and lasted through out the duration of the exposure. Conclusions The clinical significance of the effects was assessed by a clinician at the U.S. Food and Drug Administration. The effects were determined to be clinically significant only if they occurred for extended period of time. There were no observed effects from the other 5 implantable neurostimulators or during exposures from other RFID emitters.

  18. In search of new methods. Qigong in stuttering therapy

    Directory of Open Access Journals (Sweden)

    Paweł Półrola

    2013-10-01

    Full Text Available Introduction : Even though stuttering is probably as old a phenomenon as the human speech itself, the stuttering therapy is still a challenge for the therapist and requires constant searching for new methods. Qigong may prove to be one of them. Aim of the research: The research paper presents the results of an experimental investigation evaluating the usefulness of qigong practice in stuttering therapy. Material and methods: Two groups of stuttering adults underwent 6-month therapy. In group I – the experimental one (n = 11 – the therapy consisted of speech fluency training, psychotherapy and qigong practice. In group II – the control one (n = 12 – it included speech fluency training and psychotherapy. In both groups 2-hour sessions of speech fluency training and psychotherapy were conducted twice a week. Two-hour qigong sessions took place once a week. Results: After 6 months the therapy results were compared with regard to the basic stuttering parameters, such as the degree of speech disfluency, the level of logophobia and speech disfluency symptoms. Improvement was observed in both groups, the beneficial effects, however, being more prominent in the qigong-practising group. Conclusions : Qigong exercises used in the therapy of stuttering people along with speech fluency training and psychotherapy give beneficial effects.

  19. Low emittance configuration for spear

    International Nuclear Information System (INIS)

    Blumberg, L.N.; Harris, J.; Stege, R.; Cerino, J.; Hettel, R.; Hofmann, A.; Liu, R.Z.; Wiedemann, H.; Winick, H.

    1985-01-01

    The quality of synchrotron radiation beams from SPEAR, in particular the brilliance of undulator radiation, can be improved significantly by reducing the emittance of the stored electron beam. A reduction of the horizontal emittance by a factor of 3.5 to a value of 130 nanometer-radians (nm-r) at 3 GeV has been achieved by using stronger focussing, mainly in the horizontal plane. The low emittance configuration also reduces the dispersion and vertical beta functions in the straight sections, making them more suitable for wigglers. The higher betatron tunes lead to a larger phase advance between the two kickers, which has to be corrected during injection by shunting current from some quadrupoles. The configuration was optimized within SPEAR hardware limitations and tested for dynamic aperture with the tracking program PATRICIA. After implementation of this scheme, beam was successfully injected and accumulated. The measured emittance of the stored beam was in agreement with calculations. Presently the configuration is being made operational

  20. Development of medical application methods using radiation. Radionuclide therapy

    International Nuclear Information System (INIS)

    Choi, Chang Woon; Lim, S. M.; Kim, E.H.; Woo, K. S.; Chung, W. S.; Lim, S. J.; Choi, T. H.; Hong, S. W.; Chung, H. Y.; No, W. C.; Oh, B. H.; Hong, H. J.

    1999-04-01

    In this project, we studied following subjects: 1. development of monoclonal antibodies and radiopharmaceuticals 2. clinical applications of radionuclide therapy 3. radioimmunoguided surgery 4. prevention of restenosis with intracoronary radiation. The results can be applied for the following objectives: 1) radionuclide therapy will be applied in clinical practice to treat the cancer patients or other diseases in multi-center trial. 2) The newly developed monoclonal antibodies and biomolecules can be used in biology, chemistry or other basic life science research. 3) The new methods for the analysis of therapeutic effects, such as dosimetry, and quantitative analysis methods of radioactivity, can be applied in basic research, such as radiation oncology and radiation biology

  1. Development of medical application methods using radiation. Radionuclide therapy

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Chang Woon; Lim, S. M.; Kim, E.H.; Woo, K. S.; Chung, W. S.; Lim, S. J.; Choi, T. H.; Hong, S. W.; Chung, H. Y.; No, W. C. [Korea Atomic Energy Research Institute. Korea Cancer Center Hospital, Seoul, (Korea, Republic of); Oh, B. H. [Seoul National University. Hospital, Seoul (Korea, Republic of); Hong, H. J. [Antibody Engineering Research Unit, Taejon (Korea, Republic of)

    1999-04-01

    In this project, we studied following subjects: 1. development of monoclonal antibodies and radiopharmaceuticals 2. clinical applications of radionuclide therapy 3. radioimmunoguided surgery 4. prevention of restenosis with intracoronary radiation. The results can be applied for the following objectives: (1) radionuclide therapy will be applied in clinical practice to treat the cancer patients or other diseases in multi-center trial. (2) The newly developed monoclonal antibodies and biomolecules can be used in biology, chemistry or other basic life science research. (3) The new methods for the analysis of therapeutic effects, such as dosimetry, and quantitative analysis methods of radioactivity, can be applied in basic research, such as radiation oncology and radiation biology.

  2. Graphene field emitters: A review of fabrication, characterization and properties

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Leifeng, E-mail: chlf@hdu.edu.cn [College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018 (China); State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027 (China); Yu, Hu; Zhong, Jiasong; Song, Lihui [College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018 (China); Wu, Jun, E-mail: wujun@hdu.edu.cn [Institute of Electron Device & Application, Hangzhou Dianzi University, Hangzhou, Zhejiang 310018 (China); Su, Weitao [College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018 (China)

    2017-06-15

    Highlights: • The preparation, characterization and field emission properties for Gs are reviewed. • The review provides an updated progress on design and construction of Gs field emitters. • The review offers fundamental insights into understanding and design of Gs emitters. • The review can broach the subject and inspire readers in field of Gs based emitters. - Abstract: Graphenes are beneficial to electrons field emission due to its high aspect ratio, high carrier density, the larger carrier mobility, excellent electrical and thermal conductivity, excellent mechanical strength and chemical stability. In recent years, graphene or reduced oxide graphene field emitters have been successfully constructed by various methods such as chemical vapor deposition, chemical exfoliation, electrophoretic deposition, screen-printing and chemical synthesis methods. Graphene emitters are tried to construct in distribution with some angles or vertical orientation with respect to the substrate surface. The vertical alignment of graphene sheets or edges arrays can facilitate efficient electron emission from the atomically thick sheets. Therefore they have even more a low turn-on and threshold-field electronic field, high field enhancement factor, high current stability and high luminance. In this review, we shortly survey and discuss recent research progress in graphene field emission properties with particular an emphasis on their preparing method, characterization and applications in devices especially for vertical graphene and single layer graphene, also including their challenges and future prospects.

  3. An Annotated Bibliography of the Gestalt Methods, Techniques, and Therapy

    Science.gov (United States)

    Prewitt-Diaz, Joseph O.

    The purpose of this annotated bibliography is to provide the reader with a guide to relevant research in the area of Gestalt therapy, techniques, and methods. The majority of the references are journal articles written within the last 5 years or documents easily obtained through interlibrary loans from local libraries. These references were…

  4. International Standardization of Pure Beta Emitters

    International Nuclear Information System (INIS)

    Los Arcos, Jose Maria; Rodriguez, Leonor

    2006-01-01

    The paper describes the traditional methods of standardization of Pure Beta Emitters, their principal characteristics, advantage and drawbacks. It does comparisons between two metrological LSC methods: Triple to double coincidence ratio (TDCR) method and the CIEMAT/NIST method and presents the result obtained with several Key Comparisons serving as practical test of both methods. Both of them represent the siferrit of methods of standardization of pure (and mixed decay) radionuclides. ESIR WG of CCRI(II) is to implement a reference exchange system for the permanent equivalence of β, α and electron capture nuclides, similar to traditional SIR gamma. ESIR project is currently testing a new XAN scintillator and operational tests of the whole system at BIPM are expected by the end of 2006 (test restricted to ESIR NMI members)

  5. Systematization of types and methods of radiation therapy methods and techniques of irradiation of patients

    International Nuclear Information System (INIS)

    Vajnberg, M.Sh.

    1991-01-01

    The paper is concerned with the principles of systematization and classification of types and methods of radiation therapy, approaches to the regulation of its terminology. They are based on the distinction of the concepts of radiation therapy and irradiation of patients. The author gives a consice historical review of improvement of the methodology of radiation therapy in the course of developing of its methods and facilities. Problems of terminology are under discussion. There is a table of types and methods of radiation therapy, methods and techniques of irradiation. In the appendices one can find a table of typical legends and examples of graphic signs to denote methods of irradiation. Potentialities of a practical use of the system are described

  6. Physical methods of treatment of complications of anti tumoral therapy

    International Nuclear Information System (INIS)

    Zhukovets, A.G.; Ulashchik, V.S.

    1998-01-01

    Numerous experimental and clinical materials about expediency of the use of physical methods for lowering of frequency and heaviness of complications of radial therapy are reviewed. One of such methods, possessing most expressed radioprotection ability, is low intensity laser radiation. Some of the authors demonstrated that use of this method move aside the time of appearance of early radial reactions. Preliminary local use of laser irradiation (λ = 510 nm) permits to avoid of development of epidermis disease and such radial reactions as ulcer and skin fibrosis in cancer patients after neutron-photon therapy. There are good results of application of ultraviolet irradiation in the region of action of ionizing radiation in the case of medical treatment of skin cancer. Low frequency magnetic field can reduce the expression of radial reactions

  7. Transverse emittance dilution due to coupler kicks in linear accelerators

    Directory of Open Access Journals (Sweden)

    Brandon Buckley

    2007-11-01

    Full Text Available One of the main concerns in the design of low emittance linear accelerators (linacs is the preservation of beam emittance. Here we discuss one possible source of emittance dilution, the coupler kick, due to transverse electromagnetic fields in the accelerating cavities of the linac caused by the power coupler geometry. In addition to emittance growth, the coupler kick also produces orbit distortions. It is common wisdom that emittance growth from coupler kicks can be strongly reduced by using two couplers per cavity mounted opposite each other or by having the couplers of successive cavities alternate from above to below the beam pipe so as to cancel each individual kick. While this is correct, including two couplers per cavity or alternating the coupler location requires large technical changes and increased cost for superconducting cryomodules where cryogenic pipes are arranged parallel to a string of several cavities. We therefore analyze consequences of alternate coupler placements. We show here that alternating the coupler location from above to below compensates the emittance growth as well as the orbit distortions. For sufficiently large Q values, alternating the coupler location from before to after the cavity leads to a cancellation of the orbit distortion but not of the emittance growth, whereas alternating the coupler location from before and above to behind and below the cavity cancels the emittance growth but not the orbit distortion. We show that cancellations hold for sufficiently large Q values. These compensations hold even when each cavity is individually detuned, e.g., by microphonics. Another effective method for reducing coupler kicks that is studied is the optimization of the phase of the coupler kick so as to minimize the effects on emittance from each coupler. This technique is independent of the coupler geometry but relies on operating on crest. A final technique studied is symmetrization of the cavity geometry in the

  8. Top-down fabrication of plasmonic nanostructures for deterministic coupling to single quantum emitters

    NARCIS (Netherlands)

    Pfaff, W.; Vos, A.; Hanson, R.

    2013-01-01

    Metal nanostructures can be used to harvest and guide the emission of single photon emitters on-chip via surface plasmon polaritons. In order to develop and characterize photonic devices based on emitter-plasmon hybrid structures, a deterministic and scalable fabrication method for such structures

  9. Sub-nanometer emittance monitor for high brightness synchrotron radiation source

    International Nuclear Information System (INIS)

    Nakajima, K.

    1991-01-01

    Method of measuring a very small beam emittance in electron storage rings is presented. The monitor can sense an intrinsic emittance of beam particles by detecting the angular distribution of Compton scatterings of laser photons on beam electrons. It is possible to achieve measurement resolution smaller than 10 -9 m-rad without difficulty. (author)

  10. Control and Data Analysis for Emittance Measuring Devices

    CERN Document Server

    Hoffmann, T

    2001-01-01

    Due to the wide range of heavy ion beam intensities and energies in the GSI linac and the associated transfer channel to the synchrotron, several different types of emittance measurement systems have been established. Many common devices such as slit/grid or dipole-sweep systems are integrated into the GSI control system. Other systems like the single shot pepper pot method using CCD-cameras or stand-alone slit/grid set-ups are connected to personal computers. An overview is given about the various systems and their software integration. Main interest is directed on the software development for emittance front-end control and data analysis such as evaluation algorithms or graphical presentation of the results. In addition, special features for improved usability of the software such as data export, project databases and automatic report generation will be presented. An outlook on a unified evaluation procedure for all different types of emittance measurement is given.

  11. Transverse emittance measurement and preservation at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Kuhn, Maria

    2016-06-20

    The Large Hadron Collider (LHC) at CERN is a high energy storage ring that provides proton and heavy ion collisions to study fundamental particle physics. The luminosity production is closely linked to emittance preservation in the accelerator. The transverse emittance is the phase space density of the beam and should be conserved when the particle beam is transformed through the accelerator. Perturbing effects, however, can lead to emittance increase and hence luminosity degradation. Measuring the emittance growth is a complex task with high intensity beams and changing energies. The machine optics and the transverse beam size have to be measured as accurately as possible. Beta function measurements with k-modulation are discussed. With this method the quadrupole focussing strength is varied and the resulting tune change is traced to determine the beta function at the quadrupole. A new k-modulation measurement tool was developed for the LHC. The fully automatic and online measurement system takes constraints of various systems such as tune measurement precision and powering limitations of the LHC superconducting circuits into account. With sinusoidal k-modulation record low beta function measurement uncertainties in the LHC have been reached. 2015 LHC beta function and β*, which is the beta function at the collision point, measurements with k-modulation will be presented. Wire scanners and synchrotron light monitors are presently used in the LHC to measure the transverse beam size. Accuracy and limitations of the LHC transverse profile monitors are discussed. During the 2012 LHC proton run it was found that wire scanner photomultiplier saturation added significant uncertainty on all measurements. A large discrepancy between emittances from wire scanners and luminosity was discovered but not solved. During Long Shutdown 1 the wire scanner system was upgraded with new photomultipliers. A thorough study of LHC wire scanner measurement precision in 2015 is presented

  12. Polarization measurements made on LFRA and OASIS emitter arrays

    Science.gov (United States)

    Geske, Jon; Sparkman, Kevin; Oleson, Jim; Laveigne, Joe; Sieglinger, Breck; Marlow, Steve; Lowry, Heard; Burns, James

    2008-04-01

    Polarization is increasingly being considered as a method of discrimination in passive sensing applications. In this paper the degree of polarization of the thermal emission from the emitter arrays of two new Santa Barbara Infrared (SBIR) micro-bolometer resistor array scene projectors was characterized at ambient temperature and at 77 K. The emitter arrays characterized were from the Large Format Resistive Array (LFRA) and the Optimized Arrays for Space-Background Infrared Simulation (OASIS) scene projectors. This paper reports the results of this testing.

  13. Modulation characteristics of graphene-based thermal emitters

    Science.gov (United States)

    Mahlmeister, Nathan Howard; Lawton, Lorreta Maria; Luxmoore, Isaac John; Nash, Geoffrey Richard

    2016-01-01

    We have investigated the modulation characteristics of the emission from a graphene-based thermal emitter both experimentally and through simulations using finite element method modelling. Measurements were performed on devices containing square multilayer graphene emitting areas, with the devices driven by a pulsed DC drive current over a range of frequencies. Simulations show that the dominant heat path is from the emitter to the underlying substrate, and that the thermal resistance between the graphene and the substrate determines the modulation characteristics. This is confirmed by measurements made on devices in which the emitting area is encapsulated by hexagonal boron nitride.

  14. Emittance measurements from the LLUMC proton accelerator

    International Nuclear Information System (INIS)

    Coutrakon, G.; Gillespie, G.H.; Hubbard, J.; Sanders, E.

    2005-01-01

    A new method of calculating beam emittances at the extraction point of a particle accelerator is presented. The technique uses the optimization programs NPSOL and MINOS developed at Stanford University in order to determine the initial values of beam size, divergence and correlation parameters (i.e. beam sigma matrix, σ ij ) that best fit measured beam parameters. These σ ij elements are then used to compute the Twiss parameters α, β, and the phase space area, ε, of the beam at the extraction point. Beam size measurements in X and Y throughout the transport line were input to the optimizer along with the magnetic elements of bends, quads, and drifts. The σ ij parameters were optimized at the accelerator's extraction point by finding the best agreement between these measured beam sizes and those predicted by TRANSPORT. This expands upon a previous study in which a 'trial and error' technique was used instead of the optimizer software, and which yielded similar results. The Particle Beam Optics Laboratory (PBO Lab TM ) program used for this paper integrates particle beam optics and other codes into a single intuitive graphically-based computing environment. This new software provides a seamless interface between the NPSOL and MINOS optimizer and TRANSPORT calculations. The results of these emittance searches are presented here for the eight clinical energies between 70 and 250 MeV currently being used at LLUMC

  15. Scanning Emitter Lifetime Imaging Microscopy for Spontaneous Emission Control

    DEFF Research Database (Denmark)

    Frimmer, Martin; Chen, Yuntian; Koenderink, A. Femius

    2011-01-01

    We report an experimental technique to map and exploit the local density of optical states of arbitrary planar nanophotonic structures. The method relies on positioning a spontaneous emitter attached to a scanning probe deterministically and reversibly with respect to its photonic environment while...

  16. Emittance control in linear colliders

    International Nuclear Information System (INIS)

    Ruth, R.D.

    1991-01-01

    Before completing a realistic design of a next-generation linear collider, the authors must first learn the lessons taught by the first generation, the SLC. Given that, they must make designs fault tolerant by including correction and compensation in the basic design. They must also try to eliminate these faults by improved alignment and stability of components. When these two efforts cross, they have a realistic design. The techniques of generation and control of emittance reviewed here provide a foundation for a design which can obtain the necessary luminosity in a next-generation linear collider

  17. Achievement of ultralow emittance coupling in the Australian Synchrotron storage ring

    Directory of Open Access Journals (Sweden)

    R. Dowd

    2011-01-01

    Full Text Available Investigations into producing an electron beam with ultralow vertical emittance have been conducted using the Australian Synchrotron 3 GeV storage ring. A method of tuning the emittance coupling (ϵ_{y}/ϵ_{x} has been developed using a machine model calibrated through the linear optics from closed orbits method. Direct measurements of the beam emittance have not been possible due to diagnostic limitations, however two independent indirect measurements both indicate a vertical emittance of 1.2–1.3 pm rad (ϵ_{y}/ϵ_{x}=0.01%. Other indirect measurements support the validity of these results. This result is the smallest vertical emittance currently achieved in a storage ring.

  18. Emittance Growth in the NLCTA First Chicane

    International Nuclear Information System (INIS)

    Sun, Yipeng

    2011-01-01

    In this paper, the emittance growth in the NLCTA (Next Linear Collider Test Accelerator) first chicane region is evaluated by simulation studies. It is demonstrated that the higher order fields of the chicane dipole magnet and the dipole corrector magnet (which is attached on the quadrupoles) are the main contributions for the emittance growth, especially for the case with a large initial emittance (γε 0 = 5 (micro)m for instance). These simulation results agree with the experimental observations.

  19. Optical characterization of OLED emitter properties by radiation pattern analyses

    Energy Technology Data Exchange (ETDEWEB)

    Flaemmich, Michael

    2011-09-08

    Researches in both, academia and industry are investigating optical loss channels in OLED layered systems by means of optical simulation tools in order to derive promising concepts for a further enhancement of the overall device performance. Besides other factors, the prospects of success of such optimization strategies rely severely on the credibility of the optical input data. The present thesis provides a guideline to measure the active optical properties of OLED emitter materials in situ by radiation pattern analyses. Reliable and widely applicable methods are introduced to determine the internal electroluminescence spectrum, the profile of the emission zone, the dipole emitter orientation, and the internal luminescence quantum efficiency of emissive materials from the optical far field emission of OLEDs in electrical operation. The proposed characterization procedures are applied to sets of OLEDs containing both, fluorescent polymeric materials as well as phosphorescent small-molecular emitters, respectively. On the one hand, quite expected results are obtained. On the other hand, several novel and truly surprising results are found. Most importantly, this thesis contains the first report of a non-isotropic, mainly parallel emitter orientation in a phosphorescent small-molecular guest-host system (Ir(MDQ)2(acac) in a-NPD). Due to the latter result, emitter orientation based optimization of phosphorescent OLEDs seems to be within reach. Since parallel dipoles emit preferably into air, the utilization of smart emissive materials with advantageous molecular orientation is capable to boost the efficiency of phosphorescent OLEDs by 50%. Materials design, the influence of the matrix material and the substrate, as well as film deposition conditions are just a few parameters that need to be studied further in order to exploit the huge potential of the dipole emitter orientation in phosphorescent OLEDs.

  20. Hybrid emitter all back contact solar cell

    Science.gov (United States)

    Loscutoff, Paul; Rim, Seung

    2016-04-12

    An all back contact solar cell has a hybrid emitter design. The solar cell has a thin dielectric layer formed on a backside surface of a single crystalline silicon substrate. One emitter of the solar cell is made of doped polycrystalline silicon that is formed on the thin dielectric layer. The other emitter of the solar cell is formed in the single crystalline silicon substrate and is made of doped single crystalline silicon. The solar cell includes contact holes that allow metal contacts to connect to corresponding emitters.

  1. Chemically doped three-dimensional porous graphene monoliths for high-performance flexible field emitters.

    Science.gov (United States)

    Kim, Ho Young; Jeong, Sooyeon; Jeong, Seung Yol; Baeg, Kang-Jun; Han, Joong Tark; Jeong, Mun Seok; Lee, Geon-Woong; Jeong, Hee Jin

    2015-03-12

    Despite the recent progress in the fabrication of field emitters based on graphene nanosheets, their morphological and electrical properties, which affect their degree of field enhancement as well as the electron tunnelling barrier height, should be controlled to allow for better field-emission properties. Here we report a method that allows the synthesis of graphene-based emitters with a high field-enhancement factor and a low work function. The method involves forming monolithic three-dimensional (3D) graphene structures by freeze-drying of a highly concentrated graphene paste and subsequent work-function engineering by chemical doping. Graphene structures with vertically aligned edges were successfully fabricated by the freeze-drying process. Furthermore, their number density could be controlled by varying the composition of the graphene paste. Al- and Au-doped 3D graphene emitters were fabricated by introducing the corresponding dopant solutions into the graphene sheets. The resulting field-emission characteristics of the resulting emitters are discussed. The synthesized 3D graphene emitters were highly flexible, maintaining their field-emission properties even when bent at large angles. This is attributed to the high crystallinity and emitter density and good chemical stability of the 3D graphene emitters, as well as to the strong interactions between the 3D graphene emitters and the substrate.

  2. Microdosimetry of monoclonal antibodies labeled with alpha emitters

    International Nuclear Information System (INIS)

    Fisher, D.R.

    1986-01-01

    The recent discovery of new techniques for the production of monoclonal antibodies (MoAB) has opened up a number of potential new applications in cancer diagnosis and therapy. Monoclonal antibodies labeled with alpha-emitting radionuclides promise to be particularly effective therapeutic agents due to the efficient cell killing ability of highly ionizing, short-range alpha particle tracks localized at specific antigen sites within the tumor mass. For a radioimmunotherapy treatment plan to be effective, one must be able to estimate the absorbed radiation dose to both tumor cells and normal tissues in the body. However, conventional methods used in nuclear medicine for estimating absorbed doses and specific absorbed fractions for radiopharmaceuticals do not apply to alpha emitters owing to their short range and the large variations in the local distribution of energy at the cellular level that result. Microdosimetric techniques developed for assessment of the radiological effects of internally deposited transuranic radionuclides take into account the statistical aspects of alpha particle track structure, energy distribution patterns, and radionuclide distribution within tissues, and provide a means for determining the number and frequency of cells irradiated, the probability densities in specific energy, and the average dose delivered to cells of interest. These techniques can be applied to the study of radiation absorbed dose from alpha-labeled monoclonal antibodies. 16 references, 6 figures

  3. Emittance control in linear colliders

    International Nuclear Information System (INIS)

    Ruth, R.D.

    1991-05-01

    In this paper, we discuss the generation and control of the emittance in a next-generation linear collider. The beams are extracted from a damping ring and compressed in length by the first bunch compressor. They are then accelerated in a preaccelerator linac up to an energy appropriate for injection into a high gradient linac. In many designs this pre-acceleration is followed by another bunch compression to reach a short bunch. After acceleration in the linac, the bunches are finally focused transversely to a small spot. The proposed vertical beam sizes at the interaction point are the order of a few nanometers while the horizontal sizes are about a factor of 100 larger. This cross-sectional area is about a factor of 10 4 smaller than the SLC. However, the main question is: what are the tolerances to achieve such a small size, and how do they compare to present techniques for alignment and stability? These tolerances are very design dependent. Alignment tolerances in the linac can vary from 1 μm to 100 μm depending upon the basic approach. In this paper we discuss techniques of emittance generation and control which move alignment tolerances to the 100 μm range

  4. Beta emitter radionuclides (90Sr contamination in animal feed: validation and application of a radiochemical method by ultra low level liquid scintillation counting

    Directory of Open Access Journals (Sweden)

    Marco Iammarino

    2015-02-01

    Full Text Available 90Sr is considered as a dangerous contaminant of agri-food supply chains due to its chemical affinity with Calcium, which makes its absorption in bones easy. 90Sr accumulation in raw materials and then in final products is particularly significant in relationship to its ability to transfer into animal source products. The radionuclides transfer (137Cs and 90Sr from environment to forages and then to products of animal origin (milk, cow and pork meats was studied and evaluated in different studies, which were carried out in contaminated areas, from Chernobyl disaster until today. In the present work, the development and validation of a radiochemical method for the detection of 90Sr in different types of animal feed, and the application of this technique for routinely control activities, are presented. Liquid scintillation counting was the employed analytical technique, since it is able to determine very low activity concentrations of 90Sr (<0.01 Bq kg–1. All samples analysed showed a 90Sr contamination much higher than method detection limit (0.008 Bq kg–1. In particular, the highest mean activity concentration was registered in hay samples (2.93 Bq kg–1, followed by silage samples (2.07 Bq kg–1 and animal feeds (0.77 Bq kg–1. In fact, all samples were characterized by 90Sr activity concentrations much lower than reference limits. This notwithstanding, the necessity to monitor these levels was confirmed, especially considering that 90Sr is a possible carcinogen for human.

  5. Proton therapy analysis using the Monte Carlo method

    Energy Technology Data Exchange (ETDEWEB)

    Noshad, Houshyar [Center for Theoretical Physics and Mathematics, AEOI, P.O. Box 14155-1339, Tehran (Iran, Islamic Republic of)]. E-mail: hnoshad@aeoi.org.ir; Givechi, Nasim [Islamic Azad University, Science and Research Branch, Tehran (Iran, Islamic Republic of)

    2005-10-01

    The range and straggling data obtained from the transport of ions in matter (TRIM) computer program were used to determine the trajectories of monoenergetic 60 MeV protons in muscle tissue by using the Monte Carlo technique. The appropriate profile for the shape of a proton pencil beam in proton therapy as well as the dose deposited in the tissue were computed. The good agreements between our results as compared with the corresponding experimental values are presented here to show the reliability of our Monte Carlo method.

  6. Linear algebraic methods applied to intensity modulated radiation therapy.

    Science.gov (United States)

    Crooks, S M; Xing, L

    2001-10-01

    Methods of linear algebra are applied to the choice of beam weights for intensity modulated radiation therapy (IMRT). It is shown that the physical interpretation of the beam weights, target homogeneity and ratios of deposited energy can be given in terms of matrix equations and quadratic forms. The methodology of fitting using linear algebra as applied to IMRT is examined. Results are compared with IMRT plans that had been prepared using a commercially available IMRT treatment planning system and previously delivered to cancer patients.

  7. Beta-delayed proton emitter $^{113}Xe$

    CERN Document Server

    Hagberg, E; Jonson, B; Jørgensen, B; Kugler, E; Mowinckel, T

    1973-01-01

    The ISOLDE facility at the CERN synchrocyclotron has been used for extending the series of beta -delayed proton emitters in xenon to masses lighter than those previously observed (/sup 115,117/Xe). Owing to the rapid decrease of the yields, experiments with solid-state counters were inconclusive, and instead a new and much more sensitive method based on nuclear emulsions was developed. The mass range 111-114 showed one new activity, /sup 113/Xe, with a half-life of 2.8+or-0.2 sec. From measurements of the track lengths for a total of 1130 protons from /sup 113/Xe it was possible to determine the energy spectrum. The results extend the systematics of beta -strength functions in the light xenon isotopes. (19 refs).

  8. Coupling single emitters to quantum plasmonic circuits

    DEFF Research Database (Denmark)

    Huck, Alexander; Andersen, Ulrik Lund

    2016-01-01

    In recent years, the controlled coupling of single-photon emitters to propagating surface plasmons has been intensely studied, which is fueled by the prospect of a giant photonic nonlinearity on a nanoscaled platform. In this article, we will review the recent progress on coupling single emitters...

  9. Positron emitter labeled enzyme inhibitors

    International Nuclear Information System (INIS)

    Fowler, J.S.; MacGregor, R.R.; Wolf, A.P.; Langstrom, B.

    1990-01-01

    This invention involves a new strategy for imagining and mapping enzyme activity in the living human and animal body using positron emitter-labeled suicide enzyme inactivators or inhibitors which become covalently bound to the enzyme as a result of enzymatic catalysis. Two such suicide inactivators for monoamine oxidase have been labeled with carbon-11 and used to map the enzyme subtypes in the living human and animal body using PET. By using positron emission tomography to image the distribution of radioactivity produced by the body penetrating radiation emitted by carbon-11, a map of functionally active monoamine oxidase activity is obtained. Clorgyline and L-deprenyl are suicide enzyme inhibitors and irreversibly inhibit monoamine oxidase. When these inhibitors are labeled with carbon-11 they provide selective probes for monoamine oxidase localization and reactivity in vivo using positron emission tomography

  10. High current plasma electron emitter

    International Nuclear Information System (INIS)

    Fiksel, G.; Almagri, A.F.; Craig, D.

    1995-07-01

    A high current plasma electron emitter based on a miniature plasma source has been developed. The emitting plasma is created by a pulsed high current gas discharge. The electron emission current is 1 kA at 300 V at the pulse duration of 10 ms. The prototype injector described in this paper will be used for a 20 kA electrostatic current injection experiment in the Madison Symmetric Torus (MST) reversed-field pinch. The source will be replicated in order to attain this total current requirement. The source has a simple design and has proven very reliable in operation. A high emission current, small size (3.7 cm in diameter), and low impurity generation make the source suitable for a variety of fusion and technological applications

  11. Physico-technical progress in neutron-capture therapy method

    International Nuclear Information System (INIS)

    Kanda, Keiji; Furubayashi, Toru; Aoki, Kazuhiko

    1985-01-01

    This paper describes mainly development studies on the determination method of in vivo 10 B for the purpose of employment for neutron capture therapy for malignant melanoma and other tumors. To darify the efficacy of the neutron capture therapy, it is necessary to determine 10 B concentration in the diseased part. This study aimed at in vivo 10 B concention determination in living sample to the level of ppm order with 10 % of analytical error within 1 hour, and these determination conditions were satified by prompt γ-ray (478 keV) determination of 10 B (n, αγ) 7 Li reaction. This method required no sample pretreatment. Further, data normalization by γ-ray of H(n, γ)D reaction permitted no disturbance by sample shape or size. Lower limit of detection of the proposed method was estimated in terms of measuring time and statistical error by the equations of 10 B concentration and error analysis derived by the authors. As for the effect of prompt γ-rays of 23 Na(n, γ) 24 Na and 6 Li(n, γ) 7 Li reactions, it was clarified that the former showed no disturbance but some correction was necessary in case of less than 0.1 g of smaple size owing to the latter reaction. In vivo sample determination showed the proposed method was practical. In this paper some results of phantom experiment for in vivo non-destructive 10 B measurement and related simulation calculation, and examination of effect of (γ, n) reaction in heavy water of biomedical irradiation equipment on radiation quality were also described. (Takagi, S.)

  12. Selective solar absorber emittance measurement at elevated temperature

    Science.gov (United States)

    Giraud, Philémon; Braillon, Julien; Raccurt, Olivier

    2017-06-01

    Durability of solar components for CSP (Concentrated Solar Power Plant) technologies is a key point to lower cost and ensure their large deployment. These technologies concentrated the solar radiation by means of mirrors on a receiver tube where it is collected as thermal energy. The absorbers are submitted to strong environmental constraints and the degradation of their optical properties (emittance and solar absorbance) have a direct impact on performance. The characterization of a material in such condition is complicated and requires advanced apparatuses, and different measurement methods exist for the determination of the two quantities of relevance regarding an absorber, which are its emittance and its solar absorbance. The objective is to develop new optical equipment for measure the emittance of this solar absorber at elevated temperature. In this paper, we present an optical bench developed for emittance measurement on absorbers is conditions of use. Results will be shown, with a discussion of some factors of influence over this measurement and how to control them.

  13. Development and characterization of a rare earth emitter for a thermophotovoltaic power generator

    Energy Technology Data Exchange (ETDEWEB)

    Durisch, W; Panitz, J C [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1997-06-01

    Energy conversion based on thermophotovoltaic (TPV) methods has recently attracted renewed interest. Efforts at PSI are directed towards the development of a modular TPV system based on existing technology to demonstrate the feasibility of this method. Here, we report first results obtained with a prototype TPV generator based upon a modified rare earth emitter, a heat reflecting filter and commercial silicon solar cells. The preparation of the modified emitter is described, and first results of spectroscopic and electrical characterization of the TPV system are presented. The introduction of the modified emitter leads to an efficiency gain of 30-40%. (author) 3 figs., 4 refs.

  14. Decoupling Intensity Radiated by the Emitter in Distance Estimation from Camera to IR Emitter

    Directory of Open Access Journals (Sweden)

    Carlos Andrés Luna Vázquez

    2013-05-01

    Full Text Available Various models using radiometric approach have been proposed to solve the problem of estimating the distance between a camera and an infrared emitter diode (IRED. They depend directly on the radiant intensity of the emitter, set by the IRED bias current. As is known, this current presents a drift with temperature, which will be transferred to the distance estimation method. This paper proposes an alternative approach to remove temperature drift in the distance estimation method by eliminating the dependence on radiant intensity. The main aim was to use the relative accumulated energy together with other defined models, such as the zeroth-frequency component of the FFT of the IRED image and the standard deviation of pixel gray level intensities in the region of interest containing the IRED image. By using the abovementioned models, an expression free of IRED radiant intensity was obtained. Furthermore, the final model permitted simultaneous estimation of the distance between the IRED and the camera and the IRED orientation angle. The alternative presented in this paper gave a 3% maximum relative error over a range of distances up to 3 m.

  15. Shadow photography method for beam emittance measurement

    International Nuclear Information System (INIS)

    Kashkovskij, V.V.; Lisin, V.A.

    1988-01-01

    Improved technique of shadow photography which allows to measure rather simply and accurately the angular distribution of electrons extracted from betatron is described. Measurement accuracy of particle flight angles is determined by setting of rods relatively to the plane of photographic paper sheet, their diameter and shadow trace length. Incidental angle deviation of rod axes contributes mainly into the error. Mean root-square error constituted 2-3% according to the results of several measurements of angles

  16. Cough: neurophysiology, methods of research, pharmacological therapy and phonoaudiology

    Directory of Open Access Journals (Sweden)

    Balbani, Aracy Pereira Silveira

    2012-01-01

    Full Text Available Introduction: The cough is the more common respiratory symptom in children and adults. Objective: To present a revision on the neurophysiology and the methods for study of the consequence of the cough, as well as the pharmacotherapy and phonoaudiology therapy of the cough, based on the works published between 2005 and 2010 and indexed in the bases Medline, Lilacs and Library Cochrane under them to keywords "cough" or "anti-cough". Synthesis of the data: The consequence of the cough involves activation of receiving multiples becomes vacant in the aerial ways and of neural projections of the nucleus of the solitary treatment for other structures of the central nervous system. Experimental techniques allow studying the consequence of the cough to the cellular and molecular level to develop new anti-cough agents. It does not have evidences of that anti-cough exempt of medical lapsing they have superior effectiveness to the one of placebo for the relief of the cough. The phonoaudiology therapy can benefit patients with refractory chronic cough to the pharmacological treatment, over all when paradoxical movement of the vocal folds coexists. Final Comments: The boarding to multidiscipline has basic paper in the etiological diagnosis and treatment of the cough. The otolaryngologist must inform the patients on the risks of the anti-cough of free sales in order to prevent adverse poisonings and effect, especially in children.

  17. Increase of intrinsic emittance induced by multiphoton photoemission from copper cathodes illuminated by femtosecond laser pulses

    Science.gov (United States)

    An, Chenjie; Zhu, Rui; Xu, Jun; Liu, Yaqi; Hu, Xiaopeng; Zhang, Jiasen; Yu, Dapeng

    2018-05-01

    Electron sources driven by femtosecond laser have important applications in many aspects, and the research about the intrinsic emittance is becoming more and more crucial. The intrinsic emittance of polycrystalline copper cathode, which was illuminated by femtosecond pulses (FWHM of the pulse duration was about 100 fs) with photon energies above and below the work function, was measured with an extremely low bunch charge (single-electron pulses) based on free expansion method. A minimum emittance was obtained at the photon energy very close to the effective work function of the cathode. When the photon energy decreased below the effective work function, emittance increased rather than decreased or flattened out to a constant. By investigating the dependence of photocurrent density on the incident laser intensity, we found the emission excited by pulsed photons with sub-work-function energies contained two-photon photoemission. In addition, the portion of two-photon photoemission current increased with the reduction of photon energy. We attributed the increase of emittance to the effect of two-photon photoemission. This work shows that conventional method of reducing the photon energy of excited light source to approach the room temperature limit of the intrinsic emittance may be infeasible for femtosecond laser. There would be an optimized photon energy value near the work function to obtain the lowest emittance for pulsed laser pumped photocathode.

  18. A standardized method for beam design in neutron capture therapy

    International Nuclear Information System (INIS)

    Storr, G.J.: Harrington, B.V.

    1993-01-01

    A desirable end point for a given beam design for Neutron Capture Therapy (NCT) should be quantitative description of tumour control probability and normal tissue damage. Achieving this goal will ultimately rely on data from NCT human clinical trials. Traditional descriptions of beam designs have used a variety of assessment methods to quantify proposed or installed beam designs. These methods include measurement and calculation of open-quotes free fieldclose quotes parameters, such as neutron and gamma flux intensities and energy spectra, and figures-of-merit in tissue equivalent phantoms. The authors propose here a standardized method for beam design in NCT. This method would allow all proposed and existing NCT beam facilities to be compared equally. The traditional approach to determining a quantitative description of tumour control probability and normal tissue damage in NCT research may be described by the following path: Beam design → dosimetry → macroscopic effects → microscopic effects. Methods exist that allow neutron and gamma fluxes and energy dependence to be calculated and measured to good accuracy. By using this information and intermediate dosimetric quantities such as kerma factors for neutrons and gammas, macroscopic effect (absorbed dose) in geometries of tissue or tissue-equivalent materials can be calculated. After this stage, for NCT the data begins to become more sparse and in some areas ambiguous. Uncertainties in the Relative Biological Effectiveness (RBE) of some NCT dose components means that beam designs based on assumptions considered valid a few years ago may have to be reassessed. A standard method is therefore useful for comparing different NCT facilities

  19. Extracting the emitter orientation in organic light-emitting diodes from external quantum efficiency measurements

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Tobias D., E-mail: Tobias.Schmidt@physik.uni-augsburg.de; Reichardt, Lukas J.; Wehrmeister, Sebastian; Scholz, Bert J.; Mayr, Christian; Brütting, Wolfgang, E-mail: Wolfgang.Bruetting@physik.uni-augsburg.de [Institute of Physics, University of Augsburg, 86135 Augsburg (Germany); Rausch, Andreas F.; Wehlus, Thomas; Reusch, Thilo C. G. [OSRAM OLED GmbH, Wernerwerkstrasse 2, 93049 Regensburg (Germany); Ciarnáin, Rossá Mac; Danz, Norbert [Fraunhofer Institute for Applied Optics and Precision Engineering, 07745 Jena (Germany)

    2014-07-28

    Emitter orientation will play a major role in future applications of organic light-emitting diodes due to its strong impact on the efficiency of the devices. Up to now, determining the orientation of transition dipole moments required elaborate angular-dependent measurements of the light emission pattern. In this paper, we present a simplified and straightforward method to extract the emitter orientation from external quantum efficiency measurements. We demonstrate the validity of the method on three different dye-doped emitting systems.

  20. On the standardization of positron emitters by 4πγ counting

    International Nuclear Information System (INIS)

    Garcia-Torano, Eduardo; Peyres, Virginia; Roteta, Miguel

    2007-01-01

    This paper focuses on the application of the method known as ''4πγ counting'' to the standardization of positron emitters. Measurements and Monte Carlo simulations have been used to determine the optimal conditions of application. Two positron emitters ( 22 Na and 18 F) have been standardized, and the results are compared to those obtained by other methods. A good agreement has been found

  1. Multi-function radar emitter identification based on stochastic syntax-directed translation schema

    OpenAIRE

    Liu, Haijun; Yu, Hongqi; Sun, Zhaolin; Diao, Jietao

    2014-01-01

    To cope with the problem of emitter identification caused by the radar words’ uncertainty of measured multi-function radar emitters, this paper proposes a new identification method based on stochastic syntax-directed translation schema (SSDTS). This method, which is deduced from the syntactic modeling of multi-function radars, considers the probabilities of radar phrases appearance in different radar modes as well as the probabilities of radar word errors occurrence in different radar phrases...

  2. Simple emittance measurement of H- beams from a large plasma source

    International Nuclear Information System (INIS)

    Guharay, S.K.; Tsumori, K.; Hamabe, M.; Takeiri, Y.; Kaneko, O.; Kuroda, T.

    1996-03-01

    An emittance meter is developed using pepper-pot method. Kapton foils are used to detect intensity distributions of small beamlets at the 'image' plane of the pepper-pot. Emittance of H - beams from a large plasma source for the neutral beam injector of the Large Helical Device (LHD) has been measured. The normalized emittance (95%) of a 6 mA H - beam with emission current density of about 10 mA/cm 2 is ∼0.59 mm mrad. The present system is very simple, and it eliminates many complexities of the existing schemes. (author)

  3. Thermal Emittance Measurement of the Cs2Te Photocathode in FZD Superconducting RF

    CERN Document Server

    Xiang, R; Michel, P; Murcek, P; Teichert, J

    2010-01-01

    The thermal emittance of the photocathode is an interesting physical property for the photoinjector, because it decides the minimum emittance the photoinjector can finally achieve. In this paper we will report the latest results of the thermal emittance of the Cs2Te photocathode in FZD Superconducting RF gun. The measurement is performed with solenoid scan method with very low bunch charge and relative large laser spot on cathode, in order to reduce the space charge effect as much as possible, and meanwhile to eliminate the wake fields and the effect from beam halos.

  4. Thiourea derivatives, methods of their preparation and their use in neutron capture therapy of malignant melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Gabel, D.

    1991-06-04

    The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy. No Drawings

  5. Accurate estimation of the RMS emittance from single current amplifier data

    International Nuclear Information System (INIS)

    Stockli, Martin P.; Welton, R.F.; Keller, R.; Letchford, A.P.; Thomae, R.W.; Thomason, J.W.G.

    2002-01-01

    This paper presents the SCUBEEx rms emittance analysis, a self-consistent, unbiased elliptical exclusion method, which combines traditional data-reduction methods with statistical methods to obtain accurate estimates for the rms emittance. Rather than considering individual data, the method tracks the average current density outside a well-selected, variable boundary to separate the measured beam halo from the background. The average outside current density is assumed to be part of a uniform background and not part of the particle beam. Therefore the average outside current is subtracted from the data before evaluating the rms emittance within the boundary. As the boundary area is increased, the average outside current and the inside rms emittance form plateaus when all data containing part of the particle beam are inside the boundary. These plateaus mark the smallest acceptable exclusion boundary and provide unbiased estimates for the average background and the rms emittance. Small, trendless variations within the plateaus allow for determining the uncertainties of the estimates caused by variations of the measured background outside the smallest acceptable exclusion boundary. The robustness of the method is established with complementary variations of the exclusion boundary. This paper presents a detailed comparison between traditional data reduction methods and SCUBEEx by analyzing two complementary sets of emittance data obtained with a Lawrence Berkeley National Laboratory and an ISIS H - ion source

  6. Multisystemic Therapy and Functional Family Therapy Compared on their Effectiveness Using the Propensity Score Method.

    Science.gov (United States)

    Eeren, Hester V; Goossens, Lucas M A; Scholte, Ron H J; Busschbach, Jan J V; van der Rijken, Rachel E A

    2018-01-09

    Multisystemic Therapy (MST) and Functional Family Therapy (FFT) have overlapping target populations and treatment goals. In this study, these interventions were compared on their effectiveness using a quasi-experimental design. Between October, 2009 and June, 2014, outcome data were collected from 697 adolescents (mean age 15.3 (SD 1.48), 61.9% male) assigned to either MST or FFT (422 MST; 275 FFT). Data were gathered during Routine Outcome Monitoring. The primary outcome was externalizing problem behavior (Child Behavior Checklist and Youth Self Report). Secondary outcomes were the proportion of adolescents living at home, engaged in school or work, and who lacked police contact during treatment. Because of the non-random assignment, a propensity score method was used to control for observed pre-treatment differences. Because the risk-need-responsivity (RNR) model guided treatment assignment, effectiveness was also estimated in youth with and without a court order as an indicator of their risk level. Looking at the whole sample, no difference in effect was found with regard to externalizing problems. For adolescents without a court order, effects on externalizing problems were larger after MST. Because many more adolescents with a court order were assigned to MST compared to FFT, the propensity score method could not balance the treatment groups in this subsample. In conclusion, few differences between MST and FFT were found. In line with the RNR model, higher risk adolescents were assigned to the more intensive treatment, namely MST. In the group with lower risk adolescents, this more intensive treatment was more effective in reducing externalizing problems.

  7. Internal emitter research and standard setting

    International Nuclear Information System (INIS)

    Stannard, J.N.

    1981-01-01

    The history of the use of data from internal emitter research in the derivation of safety standards is reviewed. At first, observed biological effects were correlated with body burdens or exposure levels. This direct approach is illustrated by detailed accounts of the cases of uranium and plutonium. In the 1950's, when it was decided to provide standards for over 200 isotopes, the direct approach was replaced by a system of calculations. This necessitated changes in internal emitter research programs to provide metabolic data, and the development of models such as Reference Man and the Lung and Gastrointestinal Tract models. The continuing contribution of internal emitter research to standard setting can be seen in the references quoted in the metabolic data section of the new ICRP report (ICRP Publication 30). Present trends suggest a possible return to the direct use of internal emitter effects data for obtaining risk estimates. (U.K.)

  8. Beam emittance measurements on multicusp ion sources

    Energy Technology Data Exchange (ETDEWEB)

    Sarstedt, M.; Lee, Y.; Leung, K.N. [and others

    1995-08-01

    Multicusp ion sources are used for various applications. Presently, the implementation of this type of ion source planned for the development of an ion beam lithography machine, which will be used for the projection of sub-0.2 {mu}m patterns onto a wafer substrate. Since, for this application, a very good beam quality and a small ion energy spread are required, emittance measurements have been performed on a multicusp ion source for various source conditions. It is shown that the installation of proper capacitors between the extraction electrodes is necessary to avoid rf-pickup, which otherwise leads to a distortion of the beam emittance. The influence of the magnetic filter field on the beam emittance has been investigated, and the beam emittance of a dc filament-discharge plasma has also been compared to that of an rf-generated plasma.

  9. Beam emittance measurements on multicusp ion sources

    International Nuclear Information System (INIS)

    Sarstedt, M.; Lee, Y.; Leung, K.N.

    1995-08-01

    Multicusp ion sources are used for various applications. Presently, the implementation of this type of ion source planned for the development of an ion beam lithography machine, which will be used for the projection of sub-0.2 μm patterns onto a wafer substrate. Since, for this application, a very good beam quality and a small ion energy spread are required, emittance measurements have been performed on a multicusp ion source for various source conditions. It is shown that the installation of proper capacitors between the extraction electrodes is necessary to avoid rf-pickup, which otherwise leads to a distortion of the beam emittance. The influence of the magnetic filter field on the beam emittance has been investigated, and the beam emittance of a dc filament-discharge plasma has also been compared to that of an rf-generated plasma

  10. Self-powered detectors with thulium emitter

    International Nuclear Information System (INIS)

    Haller, P.; Klar, E.

    1978-01-01

    In addition to fission chambers, prompt-indicating self-powered (SPN) detectors are used for measuring the neutron flux density in the core of power reactors. Although current SPN detectors with a cobalt emitter give satisfactora results, detectors with other emitter materials have been analyzed and tested. The author describes the properties and decay pattern of the nuclide thulium and presents the results of measurements made while testing thulium detectors. (orig.) [de

  11. Multinozzle emitter arrays for ultrahigh-throughput nanoelectrospray mass spectrometry

    Science.gov (United States)

    Wang, Daojing; Mao, Pan; Wang, Hung-Ta; Yang, Peidong

    2017-10-17

    The present invention provides for a structure comprising a plurality of emitters, wherein a first nozzle of a first emitter and a second nozzle of a second emitter emit in two directions that are not or essentially not in the same direction; wherein the walls of the nozzles and the emitters form a monolithic whole. The present invention also provides for a structure comprising an emitter with a sharpened end from which the emitter emits; wherein the emitters forms a monolithic whole. The present invention also provides for a fully integrated separation of proteins and small molecules on a silicon chip before the electrospray mass spectrometry analysis.

  12. Recombination methods for boron neutron capture therapy dosimetry

    International Nuclear Information System (INIS)

    Golnik, N.; Tulik, P.; Zielczynski, M.

    2003-01-01

    The radiation effects of boron neutron capture therapy (BNCT) are associated with four-dose-compartment radiation field - boron dose (from 10 B(n,α) 7 Li) reaction), proton dose from 14 N(n,p) 14 C reaction, neutron dose (mainly fast and epithermal neutrons) and gamma-ray dose (external and from capture reaction 1 H(n,γ) 2 D). Because of this the relation between the absorbed dose and the biological effects is very complex and all the above mentioned absorbed dose components should be determined. From this point of view, the recombination chambers can be very useful instruments for characterization of the BNCT beams. They can be used for determination of gamma and high-LET dose components for the characterization of radiation quality of mixed radiation fields by recombination microdosimetric method (RMM). In present work, a graphite high-pressure recombination chamber filled with nitrogen, 10 BF 3 and tissue equivalent gas was used for studies on application of RMM for BNCT dosimetry. The use of these gases or their mixtures opens a possibility to design a recombination chamber for determination of the dose fractions due to gamma radiation, fast neutrons, neutron capture on nitrogen and high LET particles from (n, 10 B) reaction in simulated tissue with different content of 10 B. (author)

  13. Measurements of Thermal Emittance for Cesium Telluride Photocathodes at PITZ

    CERN Document Server

    Miltchev, V; Grabosch, H J; Han, J H; Krasilnikov, M; Oppelt, A; Petrosian, B; Staykov, L; Stephan, F

    2005-01-01

    The thermal emittance determines the lower emittance limit and its measurement is of high importance to understand the ultimate injector performance. In this contribution we present results of thermal emittance measurements under rf operation conditions for various Cs2Te cathodes and different accelerating gradients. Measurements of thermal emittance scaling with the cathode laser spot size are presented and analysed. The significance of the Schottky effect in the emittance formation process is discussed.

  14. A low-emittance lattice for SPEAR

    International Nuclear Information System (INIS)

    Safranek, J.; Wiedemann, H.

    1992-01-01

    The design and implementation of a low emittance lattice for the SPEAR storage ring including measurements of the performance of the lattice are presented (J. Safranek, Ph. D. thesis, Stanford University, 1991). The low emittance lattice is designed to optimize the performance of SPEAR as a synchrotron radiation source while keeping SPEAR hardware changes at a minimum. The horizontal emittance of the electron beam in the low emittance lattice is reduced by a factor of 4 from the previous lattice. This reduces the typical horizontal source size and divergence of the photon beams by a factor of 2 each and increases the photon beam brightness. At 3 GeV the horizontal emittance is 129 π nm rad, which makes the low emittance lattice the lowest emittance, runnning synchroton radiation source in the world in the 1.5 to 4.0 GeV energy range for the emittance scaled to 3 GeV. The measured vertical emittance was reduced to half that typically seen at SPEAR in the past. The brightness of the photon beams was further incrased by reducing β y at the insertion devices to 1.1 m and reducing the energy dispersion at the insertion devices by more than a factor of 2 on average. The horizontal despersion at the rf cavities was reduced by a factor of nearly 4 which gives much less problems with synchrobetatron resonances. The dynamic and physical apertures of the lattice are large, giving long beam lifetimes and easy injection of electrons. The measurements of the linear optics and intensity dependent phenomena gave resonable agreement with the design . The overall performance of the machine was very good. Injection rates of 10 to 20 mA/min and larger were achieved routinely, and 100 mA total current was stored. Repeated ramping of stored beam from the injection energy of 2.3 GeV to the running energy of 3.0 GeV was achieved with very little beam loss. This low emittance configuration is expected to be the operating configuration for SPEAR starting in January 1992. (orig.)

  15. Monte Carlo Transverse Emittance Study on Cs2Te

    CERN Document Server

    Banfi, F; Galimberti, P G; Giannetti, C; Pagliara, S; Parmigiani, F; Pedersoli, E

    2005-01-01

    A Monte Carlo study of electron transport in Cs2Te films is performed to investigate the transverse emittance epsilon at the cathode surface. We find the photoemitted electron angular distribution and explain the physical mechanism involved in the process, a mechanism hindered by the statistical nature of the Monte Carlo method. The effects of electron-phonon scattering are discussed. The transverse emittance is calculated for different radiation wavelengths and a laser spot size of 1.5*10(-3) m. For a laser radiation at 265 nm we find epsilon = 0.56 mm-mrad. The dependence of epsilon and the quantum yield on the electron affinity Ea is also investigated. The data shows the importance of aging/contamination on the material.

  16. Emittance preservation during bunch compression with a magnetized beam

    Energy Technology Data Exchange (ETDEWEB)

    Stratakis, Diktys [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-09-02

    The deleterious effects of coherent synchrotron radiation (CSR) on the phase-space and energy spread of high-energy beams in accelerator light sources can significantly constrain the machine design and performance. In this paper, we present a simple method to preserve the beam emittance by means of using magnetized beams that exhibit a large aspect ratio on their transverse dimensions. The concept is based on combining a finite solenoid field where the beam is generated together with a special optics adapter. Numerical simulations of this new type of beam source show that the induced phase-space density growth can be notably suppressed to less than 1% for any bunch charge. This work elucidates the key parameters that are needed for emittance preservation, such as the required field and aspect ratio for a given bunch charge.

  17. Rose, a rotating system for 4D emittance measurements

    Energy Technology Data Exchange (ETDEWEB)

    Maier, Michael; Groening, Lars; Xiao, Chen; Mickat, Sascha; Du, Xiaonan; Gerhard, Peter; Vormann, Hartmut [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH (Germany)

    2016-07-01

    A ROtating System for Emittance measurements ROSE, to measure the full 4 dimensional transverse beam matrix of a heavy ion beam has been developed and commissioned. Different heavy ion beams behind the HLI at GSI have been used in two commissioning beam times. All technical aspects of Rose have been tested, Rose has been benchmarked against existing emittance scanners for horizontal and vertical projections and the method, hard- and software to measure the 4D beam matrix has been upgraded, refined and successfully commissioned. The inter plane correlations of the HLI beam have been measured, yet as no significant initial correlations were found to be present, controlled coupling of the beam by using a skew triplet has been applied and confirmed with Rose. The next step is to use ROSE to measure and remove the known inter plane correlations of a Uranium beam before SIS18 injection.

  18. Electron Cloud at Low Emittance in CesrTA

    CERN Document Server

    Palmer, Mark; Billing, Michael; Calvey, Joseph; Conolly, Christopher; Crittenden, James; Dobbins, John; Dugan, Gerald; Eggert, Nicholas; Fontes, Ernest; Forster, Michael; Gallagher, Richard; Gray, Steven; Greenwald, Shlomo; Hartill, Donald; Hopkins, Walter; Kreinick, David; Kreis, Benjamin; Leong, Zhidong; Li, Yulin; Liu, Xianghong; Livezey, Jesse; Lyndaker, Aaron; Makita, Junki; McDonald, Michael; Medjidzade, Valeri; Meller, Robert; O'Connell, Tim; Peck, Stuart; Peterson, Daniel; Ramirez, Gabriel; Rendina, Matthew; Revesz, Peter; Rider, Nate; Rice, David; Rubin, David; Sagan, David; Savino, James; Schwartz, Robert; Seeley, Robert; Sexton, James; Shanks, James; Sikora, John; Smith, Eric; Strohman, Charles; Williams, Heather; Antoniou, Fanouria; Calatroni, Sergio; Gasior, Marek; Jones, Owain Rhodri; Papaphilippou, Yannis; Pfingstner, Juergen; Rumolo, Giovanni; Schmickler, Hermann; Taborelli, Mauro; Asner, David; Boon, Laura; Garfinkel, Arthur; Byrd, John; Celata, Christine; Corlett, John; De Santis, Stefano; Furman, Miguel; Jackson, Alan; Kraft, Rick; Munson, Dawn; Penn, Gregory; Plate, David; Venturini, Marco; Carlson, Benjamin; Demma, Theo; Dowd, Rohan; Flanagan, John; Jain, Puneet; Kanazawa, Ken-ichi; Kubo, Kiyoshi; Ohmi, Kazuhito; Sakai, Hiroshi; Shibata, Kyo; Suetsugu, Yusuke; Tobiyama, Makoto; Gonnella, Daniel; Guo, Weiming; Harkay, Katherine; Holtzapple, Robert; Jones, James; Wolski, Andrzej; Kharakh, David; Ng, Johnny; Pivi, Mauro; Wang, Lanfa; Ross, Marc; Tan, Cheng-Yang; Zwaska, Robert; Schachter, Levi; Wilkinson, Eric

    2010-01-01

    The Cornell Electron Storage Ring (CESR) has been reconfigured as a test accelerator (CesrTA) for a program of electron cloud (EC) research at ultra low emittance. The instrumentation in the ring has been upgraded with local diagnostics for measurement of cloud density and with improved beam diagnostics for the characterization of both the low emittance performance and the beam dynamics of high intensity bunch trains interacting with the cloud. A range of EC mitigation methods have been deployed and tested and their effectiveness is discussed. Measurements of the electron cloud’s effect on the beam under a range of conditions are discussed along with the simulations being used to quantitatively understand these results

  19. Emittance preservation during bunch compression with a magnetized beam

    Energy Technology Data Exchange (ETDEWEB)

    Stratakis, Diktys

    2016-03-01

    The deleterious effects of coherent synchrotron radiation (CSR) on the phase-space and energy spread of high-energy beams in accelerator light sources can significantly constrain the machine design and performance. In this paper, we present a simple method to preserve the beam emittance by means of using magnetized beams that exhibit a large aspect ratio on their transverse dimensions. The concept is based in combining a finite solenoid field where the beam is generated with a special optics adapter. Numerical simulations of this new type of beam source show that the induced phase-space density growth from CSR can be notably suppressed to less than 1% for any bunch charge. This work elucidates the key parameters that are needed for emittance preservation, such as the required field and aspect ratio for a given bunch charge.

  20. Emittance Measurement for Beamline Extension at the PET Cyclotron

    Directory of Open Access Journals (Sweden)

    Sae-Hoon Park

    2016-01-01

    Full Text Available Particle-induced X-ray emission is used for determining the elemental composition of materials. This method uses low-energy protons (of several MeV, which can be obtained from high-energy (of tens MeV accelerators. Instead of manufacturing an accelerator for generating the MeV protons, the use of a PET cyclotron has been suggested for designing the beamline for multipurpose applications, especially for the PIXE experiment, which has a dedicated high-energy (of tens MeV accelerator. The beam properties of the cyclotron were determined at this experimental facility by using an external beamline before transferring the ion beam to the experimental chamber. We measured the beam profile and calculated the emittance using the pepper-pot method. The beam profile was measured as the beam current using a wire scanner, and the emittance was measured as the beam distribution at the beam dump using a radiochromic film. We analyzed the measurement results and are planning to use the results obtained in the simulations of external beamline and aligned beamline components. We will consider energy degradation after computing the beamline simulation. The experimental study focused on measuring the emittance from the cyclotron, and the results of this study are presented in this paper.

  1. Hafnium carbide nanocrystal chains for field emitters

    International Nuclear Information System (INIS)

    Tian, Song; Li, Hejun; Zhang, Yulei; Ren, Jincui; Qiang, Xinfa; Zhang, Shouyang

    2014-01-01

    A hafnium carbide (HfC) nanostructure, i.e., HfC nanocrystal chain, was synthesized by a chemical vapor deposition (CVD) method. X-ray diffractometer, field-emission scanning electron microscope, transmission electron microscope, and energy-dispersive X-ray spectrometer were employed to characterize the product. The synthesized one-dimensional (1D) nanostructures with many faceted octahedral nanocrystals possess diameters of tens of nanometers to 500 nm and lengths of a few microns. The chain-like structures possess a single crystalline structure and preferential growth direction along the [1 0 0] crystal orientation. The growth of the chains occurred through the vapor–liquid–solid process along with a negative-feedback mechanism. The field emission (FE) properties of the HfC nanocrystal chains as the cold cathode emitters were examined. The HfC nanocrystal chains display good FE properties with a low turn-on field of about 3.9 V μm −1 and a high field enhancement factor of 2157, implying potential applications in vacuum microelectronics.

  2. Characterization of microstructured fibre emitters: in pursuit of improved nano electrospray ionization performance.

    Science.gov (United States)

    Wu, Xinyun; Oleschuk, Richard D; Cann, Natalie M

    2012-09-21

    Full-dimensional computational fluid dynamics (CFD) simulations are presented for nano electrospray ionization (ESI) with various emitter designs. Our CFD electrohydrodynamic simulations are based on the Taylor-Melcher leaky-dielectric model, and the volume of fluid technique for tracking the fast-changing liquid-gas interface. The numerical method is first validated for a conventional 20 μm inner diameter capillary emitter. The impact of ESI voltage, flow rate, emitter tapering, surface hydrophobicity, and fluid conductivity on the nano-ESI behavior are thoroughly investigated and compared with experiments. Multi-electrospray is further simulated with 2-hole and 3-hole emitters with the latter having a linear or triangular hole arrangement. The simulations predict multi-electrospray behavior in good agreement with laboratory observations.

  3. Electron field emission characteristics of graphene/carbon nanotubes hybrid field emitter

    International Nuclear Information System (INIS)

    Chen, Leifeng; He, Hong; Yu, Hua; Cao, Yiqi; Lei, Da; Menggen, QiQiGe; Wu, Chaoxing; Hu, Liqin

    2014-01-01

    The graphene (GP) and multi-walled carbon nanotubes (MCNTs) hybrid nanostructure emitter was constructed by a larger scale electrophoretic deposition (EPD) method. The field emission (FE) performance of the hybrid emitter is greatly improved compared with that of only GP or MCNTs emitter. The low turn-on electric field (EF), the low threshold EF and the reliability FE properties are obtained from the hybrid emitter. The better FE properties result from the improved electrical properties. For further enhancement FE of hybrids, Ag Nanoparticles (NPs) were decorated on the hybrids and FE characteristics were also studied. These studies indicate that we can use the hybrid nanostructure to improve conductivity and contact resistance, which results in enhancement of the FE properties

  4. Generation of low-emittance electron beams in electrostatic accelerators for FEL applications

    Science.gov (United States)

    Teng, Chen; Elias, Luis R.

    1995-02-01

    This paper reports results of transverse emittance studies and beam propagation in electrostatic accelerators for free electron laser applications. In particular, we discuss emittance growth analysis of a low current electron beam system consisting of a miniature thermoionic electron gun and a National Electrostatics Accelerator (NEC) tube. The emittance growth phenomenon is discussed in terms of thermal effects in the electron gun cathode and aberrations produced by field gradient changes occurring inside the electron gun and throughout the accelerator tube. A method of reducing aberrations using a magnetic solenoidal field is described. Analysis of electron beam emittance was done with the EGUN code. Beam propagation along the accelerator tube was studied using a cylindrically symmetric beam envelope equation that included beam self-fields and the external accelerator fields which were derived from POISSON simulations.

  5. Generation of low-emittance electron beams in electrostatic accelerators for FEL applications

    International Nuclear Information System (INIS)

    Chen Teng; Central Florida Univ., Orlando, FL; Elias, L.R. R.; Central Florida Univ., Orlando, FL

    1995-01-01

    This paper reports results of transverse emittance studies and beam propagation in electrostatic accelerators for free electron laser applications. In particular, we discuss emittance growth analysis of a low current electron beam system consisting of a miniature thermoionic electron gun and a National Electrostatics Accelerator (NEC) tube. The emittance growth phenomenon is discussed in terms of thermal effects in the electron gun cathode and aberrations produced by field gradient changes occurring inside the electron gun and throughout the accelerator tube. A method of reducing aberrations using a magnetic solenoidal field is described. Analysis of electron beam emittance was done with the EGUN code. Beam propagation along the accelerator tube was studied using a cylindrically symmetric beam envelope equation that included beam self-fields and the external accelerator fields which were derived from POISSON simulations. ((orig.))

  6. Generation of low-emittance electron beams in electrostatic accelerators for FEL applications

    Energy Technology Data Exchange (ETDEWEB)

    Chen Teng [University of Central Florida, Orlando, FL (United States). Center for Research in Electro-Optics and Lasers (CREOL)]|[Central Florida Univ., Orlando, FL (United States). Dept. of Physics; Elias, L.R. R. [University of Central Florida, Orlando, FL (United States). Center for Research in Electro-Optics and Lasers (CREOL)]|[Central Florida Univ., Orlando, FL (United States). Dept. of Physics

    1995-01-30

    This paper reports results of transverse emittance studies and beam propagation in electrostatic accelerators for free electron laser applications. In particular, we discuss emittance growth analysis of a low current electron beam system consisting of a miniature thermoionic electron gun and a National Electrostatics Accelerator (NEC) tube. The emittance growth phenomenon is discussed in terms of thermal effects in the electron gun cathode and aberrations produced by field gradient changes occurring inside the electron gun and throughout the accelerator tube. A method of reducing aberrations using a magnetic solenoidal field is described. Analysis of electron beam emittance was done with the EGUN code. Beam propagation along the accelerator tube was studied using a cylindrically symmetric beam envelope equation that included beam self-fields and the external accelerator fields which were derived from POISSON simulations. ((orig.))

  7. Room-temperature deposition of diamond-like carbon field emitter on flexible substrates

    International Nuclear Information System (INIS)

    Chen, H.; Iliev, M.N.; Liu, J.R.; Ma, K.B.; Chu, W.-K.; Badi, N.; Bensaoula, A.; Svedberg, E.B.

    2006-01-01

    Room-temperature fabrication of diamond-like carbon electron field emitters on flexible polyimide substrate is reported. These thin film field emitters are made using an Ar gas cluster ion beam assisted C 6 vapor deposition method. The bond structure of the as-deposited diamond-like carbon film was studied using Raman spectroscopy. The field emission characteristics of the deposited films were also measured. Electron current densities over 15 mA/cm 2 have been recorded under an electrical field of about 65 V/μm. These diamond-like carbon field emitters are easy and inexpensive to fabricate. The results are promising for flexible field-emission fabrication without the need of complex patterning and tip shaping as compared to the Spindt-type field emitters

  8. Generalized superradiant assembly for nanophotonic thermal emitters

    Science.gov (United States)

    Mallawaarachchi, Sudaraka; Gunapala, Sarath D.; Stockman, Mark I.; Premaratne, Malin

    2018-03-01

    Superradiance explains the collective enhancement of emission, observed when nanophotonic emitters are arranged within subwavelength proximity and perfect symmetry. Thermal superradiant emitter assemblies with variable photon far-field coupling rates are known to be capable of outperforming their conventional, nonsuperradiant counterparts. However, due to the inability to account for assemblies comprising emitters with various materials and dimensional configurations, existing thermal superradiant models are inadequate and incongruent. In this paper, a generalized thermal superradiant assembly for nanophotonic emitters is developed from first principles. Spectral analysis shows that not only does the proposed model outperform existing models in power delivery, but also portrays unforeseen and startling characteristics during emission. These electromagnetically induced transparency like (EIT-like) and superscattering-like characteristics are reported here for a superradiant assembly, and the effects escalate as the emitters become increasingly disparate. The fact that the EIT-like characteristics are in close agreement with a recent experimental observation involving the superradiant decay of qubits strongly bolsters the validity of the proposed model.

  9. Electron emitter pulsed-type cylindrical IEC

    International Nuclear Information System (INIS)

    Miley, G.H.; Gu, Y.; Stubbers, R.; Zich, R.; Anderl, R.; Hartwell, J.

    1997-01-01

    A cylindrical version of the single grid Inertial Electrostatic Confinement (IEC) device (termed the C-device) has been developed for use as a 2.5-MeV D-D fusion neutron source for neutron activation analysis. The C-device employs a hollow-tube type cathode with similar anodes backed up by ''reflector'' dishes. The resulting discharge differs from a conventional hollow cathode discharge, by creating an explicit ion beam which is ''pinched'' in the cathode region. Resulting fusion reactions generate ∼10 6 neutron/s. A pulsed version is under development for applications requiring higher fluxes. Several pulsing techniques are under study, including an electron emitter (e-emitter) assisted discharge in a thorated tungsten wire emitter located behind a slotted area in the reflector dishes. Pulsing is initiated after establishing a low power steady-state discharge by pulsing the e-emitter current using a capacitor switch type circuit. The resulting electron jet, coupled with the discharge by the biased slot array, creates a strong pulse in the pinched ion beam. The pulse length/repetition rate are controlled by the e-emitter pulse circuit. Typical parameters in present studies are ∼30micros, 10Hz and 1-amp ion current. Corresponding neutron measurements are an In-foil type activation counter for time averaged rates. Results for a wide variety of operating conditions are presented

  10. Diamond-based single-photon emitters

    International Nuclear Information System (INIS)

    Aharonovich, I; Castelletto, S; Simpson, D A; Su, C-H; Greentree, A D; Prawer, S

    2011-01-01

    The exploitation of emerging quantum technologies requires efficient fabrication of key building blocks. Sources of single photons are extremely important across many applications as they can serve as vectors for quantum information-thereby allowing long-range (perhaps even global-scale) quantum states to be made and manipulated for tasks such as quantum communication or distributed quantum computation. At the single-emitter level, quantum sources also afford new possibilities in terms of nanoscopy and bio-marking. Color centers in diamond are prominent candidates to generate and manipulate quantum states of light, as they are a photostable solid-state source of single photons at room temperature. In this review, we discuss the state of the art of diamond-based single-photon emitters and highlight their fabrication methodologies. We present the experimental techniques used to characterize the quantum emitters and discuss their photophysical properties. We outline a number of applications including quantum key distribution, bio-marking and sub-diffraction imaging, where diamond-based single emitters are playing a crucial role. We conclude with a discussion of the main challenges and perspectives for employing diamond emitters in quantum information processing.

  11. Nanometer emittance ultralow charge beams from rf photoinjectors

    Directory of Open Access Journals (Sweden)

    R. K. Li

    2012-09-01

    Full Text Available In this paper we discuss the generation of a new class of high brightness relativistic electron beams, characterized by ultralow charge (0.1–1 pC and ultralow normalized emittance (<50  nm. These beams are created in rf photoinjectors when the laser is focused on the cathode to very small transverse sizes (<30  μm rms. In this regime, the charge density at the cathode approaches the limit set by the extraction electric field. By shaping the laser pulse to have a cigarlike aspect ratio (the longitudinal dimension much larger than the transverse dimension and a parabolic temporal profile, the resulting space charge dominated dynamics creates a uniformly filled ellipsoidal distribution and the emittance can be nearly preserved to its thermal value. We also present a new method, based on a variation of the pepper-pot technique, for single shot measurements of the ultralow emittances for this new class of beams.

  12. Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage.

    Science.gov (United States)

    Gao, Liansheng; Xu, Weilin; Li, Tao; Chen, Jingyin; Shao, Anwen; Yan, Feng; Chen, Gao

    2018-01-01

    Spontaneous intracerebral hemorrhage (ICH) is one type of the most devastating cerebrovascular diseases worldwide, which causes high morbidity and mortality. However, efficient treatment is still lacking. Stem cell therapy has shown good neuroprotective and neurorestorative effect in ICH and is a promising treatment. In this study, our aim was to review the therapeutic effects, strategies, related mechanisms and safety issues of various types of stem cell for ICH treatment. Numerous studies had demonstrated the therapeutic effects of diverse stem cell types in ICH. The potential mechanisms include tissue repair and replacement, neurotrophy, promotion of neurogenesis and angiogenesis, anti-apoptosis, immunoregulation and anti-inflammation and so forth. The microenvironment of the central nervous system (CNS) can also influence the effects of stem cell therapy. The detailed therapeutic strategies for ICH treatment such as cell type, the number of cells, time window, and the routes of medication delivery, varied greatly among different studies and had not been determined. Moreover, the safety issues of stem cell therapy for ICH should not be ignored. Stem cell therapy showed good therapeutic effect in ICH, making it a promising treatment. However, safety should be carefully evaluated, and more clinical trials are required before stem cell therapy can be extensively applied to clinical use.

  13. Miniature X-ray Tube for Electric Brachytherapy using Carbon Nanotube Field Emitter

    International Nuclear Information System (INIS)

    Heo, Sung Hwan; Kim, Hyun Jin; Ha, Jun Mok; Cho, Sung Oh

    2011-01-01

    An electric brachytherapy using a miniature x-ray tube has a major advantage to reduce the x-ray exposure of human body during the cancer radiation therapy by optimal positioning of x-ray radiation source and treatment objectives. In the view of a smaller electronic x-ray source, the CNT field emitter based xray tube can be more minimized than thermionic filament emitter based one because of a simple power supplier connection of cold field emission in diode type as well as a higher electron emission brightness of CNT. This abstract is for introducing the design of a prototype CNT field emitter based miniature x-ray tube. We have vacuum sealed CNT miniature x-ray tube with 7∼10 mm diameter, and characteristics of electron emission and x-ray transportation using MCNP5 code are surveyed

  14. BEAM EMITTANCE MEASUREMENT TOOL FOR CEBAF OPERATIONS

    International Nuclear Information System (INIS)

    Chevtsov, Pavel; Tiefenback, Michael

    2008-01-01

    A new software tool was created at Jefferson Lab to measure the emittance of the CEBAF electron beams. The tool consists of device control and data analysis applications. The device control application handles the work of wire scanners and writes their measurement results as well as the information about accelerator settings during these measurements into wire scanner data files. The data analysis application reads these files and calculates the beam emittance on the basis of a wire scanner data processing model. Both applications are computer platform independent but are mostly used on LINUX PCs recently installed in the accelerator control room. The new tool significantly simplifies beam emittance measurement procedures for accelerator operations and contributes to a very high availability of the CEBAF machine for the nuclear physics program at Jefferson Lab.

  15. Solid-state single-photon emitters

    Science.gov (United States)

    Aharonovich, Igor; Englund, Dirk; Toth, Milos

    2016-10-01

    Single-photon emitters play an important role in many leading quantum technologies. There is still no 'ideal' on-demand single-photon emitter, but a plethora of promising material systems have been developed, and several have transitioned from proof-of-concept to engineering efforts with steadily improving performance. Here, we review recent progress in the race towards true single-photon emitters required for a range of quantum information processing applications. We focus on solid-state systems including quantum dots, defects in solids, two-dimensional hosts and carbon nanotubes, as these are well positioned to benefit from recent breakthroughs in nanofabrication and materials growth techniques. We consider the main challenges and key advantages of each platform, with a focus on scalable on-chip integration and fabrication of identical sources on photonic circuits.

  16. Optical Methods and Instrumentation in Brain Imaging and Therapy

    CERN Document Server

    2013-01-01

    This book provides a comprehensive up-to-date review of optical approaches used in brain imaging and therapy. It covers a variety of imaging techniques including diffuse optical imaging, laser speckle imaging, photoacoustic imaging and optical coherence tomography. A number of laser-based therapeutic approaches are reviewed, including photodynamic therapy, fluorescence guided resection and photothermal therapy. Fundamental principles and instrumentation are discussed for each imaging and therapeutic technique. Represents the first publication dedicated solely to optical diagnostics and therapeutics in the brain Provides a comprehensive review of the principles of each imaging/therapeutic modality Reviews the latest advances in instrumentation for optical diagnostics in the brain Discusses new optical-based therapeutic approaches for brain diseases

  17. Music therapy with bereaved teenagers: a mixed methods perspective.

    Science.gov (United States)

    McFerran, Katrina; Roberts, Melina; O'Grady, Lucy

    2010-07-01

    Qualitative investigations have indicated that music therapy groups may be beneficial for bereaved teenagers. The existing relationship between young people and music serves as a platform for connectedness and emotional expression that is utilised within a therapeutic, support group format. This investigation confirms this suggestion through grounded theory analysis of focus group interviews. Changes in self-perception were not found as a result of participation, however practically significant results were found on adolescent coping. These cannot be generalized because of the small sample size. Grief specific tools are recommended for use in future investigations in order to capture the emotional impact of music therapy grief work with adolescents.

  18. MD2065: Emittance exchange with linear coupling

    CERN Document Server

    Carver, Lee Robert; Persson, Tobias Hakan Bjorn; Amorim, David; Levens, Tom; Pesah, Arthur Chalom; CERN. Geneva. ATS Department

    2018-01-01

    In order to better understand the luminosity imbalance between ATLAS and CMS that was observed in 2016, it was proposed to perform a test whereby the horizontal and vertical emittances are exchanged by crossing the tunes in the presence of linear coupling. The luminosity before and after the exchange could be compared to see if the imbalance stems purely from the uneven emittances or if there is an additional mechanism in play. However, due to limited machine availability only tests at injection were able to performed.

  19. Minimum emittance of three-bend achromats

    International Nuclear Information System (INIS)

    Li Xiaoyu; Xu Gang

    2012-01-01

    The calculation of the minimum emittance of three-bend achromats (TBAs) made by Mathematical software can ignore the actual magnets lattice in the matching condition of dispersion function in phase space. The minimum scaling factors of two kinds of widely used TBA lattices are obtained. Then the relationship between the lengths and the radii of the three dipoles in TBA is obtained and so is the minimum scaling factor, when the TBA lattice achieves its minimum emittance. The procedure of analysis and the results can be widely used in achromats lattices, because the calculation is not restricted by the actual lattice. (authors)

  20. Quadrupole Transfer Function for Emittance Measurement

    CERN Document Server

    Cameron, Peter; Jansson, Andreas; Tan, Cheng-Yang

    2008-01-01

    Historically the use of the quadrupole moment measurement has been impeded by the requirement for large dynamic range, as well as measurement sensitivity to beam position. We investigate the use of the transfer function technique [1-3] in combination with the sensitivity and 160dB revolution line rejection of the direct diode detection analog front end [4] to open the possibility of an emittance diagnostic that may be implemented without operational complication, quasi- parasitic to the operation of existing tune measurement systems. Such a diagnostic would be particularly useful as an emittance monitor during acceleration ramp development in machines like RHIC and the LHC.

  1. Studies of emittance growth in the ATF

    International Nuclear Information System (INIS)

    Zimmermann, F.

    1997-03-01

    Several different mechanisms of emittance growth in the Accelerator Test Facility (ATF) at KEK are investigated: the author calculates rise times of the fast beam-ion instability for the damping ring (DR), and discusses the emittance growth caused by coherent synchrotron radiation in the beam-transport line (BT), the effect of quadrupole wake fields in the injector linac, and, finally, a single-bunch head-tail ion effect that can occur in both the DR and the BT. A first attempt to measure the quadrupole wake on the real machine is also reported

  2. Highly reliable field electron emitters produced from reproducible damage-free carbon nanotube composite pastes with optimal inorganic fillers

    Science.gov (United States)

    Kim, Jae-Woo; Jeong, Jin-Woo; Kang, Jun-Tae; Choi, Sungyoul; Ahn, Seungjoon; Song, Yoon-Ho

    2014-02-01

    Highly reliable field electron emitters were developed using a formulation for reproducible damage-free carbon nanotube (CNT) composite pastes with optimal inorganic fillers and a ball-milling method. We carefully controlled the ball-milling sequence and time to avoid any damage to the CNTs, which incorporated fillers that were fully dispersed as paste constituents. The field electron emitters fabricated by printing the CNT pastes were found to exhibit almost perfect adhesion of the CNT emitters to the cathode, along with good uniformity and reproducibility. A high field enhancement factor of around 10 000 was achieved from the CNT field emitters developed. By selecting nano-sized metal alloys and oxides and using the same formulation sequence, we also developed reliable field emitters that could survive high-temperature post processing. These field emitters had high durability to post vacuum annealing at 950 °C, guaranteeing survival of the brazing process used in the sealing of field emission x-ray tubes. We evaluated the field emitters in a triode configuration in the harsh environment of a tiny vacuum-sealed vessel and observed very reliable operation for 30 h at a high current density of 350 mA cm-2. The CNT pastes and related field emitters that were developed could be usefully applied in reliable field emission devices.

  3. Music Therapy with Bereaved Teenagers: A Mixed Methods Perspective

    Science.gov (United States)

    McFerran, Katrina; Roberts, Melina; O'Grady, Lucy

    2010-01-01

    Qualitative investigations have indicated that music therapy groups may be beneficial for bereaved teenagers. The existing relationship between young people and music serves as a platform for connectedness and emotional expression that is utilised within a therapeutic, support group format. This investigation confirms this suggestion through…

  4. A low emittance configuration for spear

    International Nuclear Information System (INIS)

    Blumberg, L.N.; Cerino, J.; Harris, J.; Hettel, R.; Hofmann, A.; Liu, R.Z.; Stego, R.; Wiedemann, H.; Winick, H.

    1985-01-01

    The quality of synchrotron radiation beams from SPEAR, in particular the brilliance of undulator radiation, can be improved significantly by reducing the emittance of the stored electron beam. A reduction of the horizontal emittance by a factor of 3.5 to a value of 130 nanometer-radians (nm-r) at 3 GeV has been achieved by using stronger focussing, mainly in the horizontal plane. The low emittance configuration also reduces the dispersion and vertical beta functions in the straight sections, making them more suitable for wigglers. The higher betatron tunes lead to a larger phase advance between the two kickers, which has to be corrected during injection by shunting current from some quadrupoles. The configuration was optimized within SPEAR hardware limitations and tested for dynamic aperture with the tracking program PATRICIA. After implementation of this scheme, beam was successfully injected and accumulated. The measured emittance of the stored beam was in agreement with calculations. Presently the configuration is being made operational

  5. Simple-to-prepare multipoint field emitter

    Science.gov (United States)

    Sominskii, G. G.; Taradaev, E. P.; Tumareva, T. A.; Mishin, M. V.; Kornishin, S. Yu.

    2015-07-01

    We investigate multitip field emitters prepared by electroerosion treatment of the surface of molybdenum samples. Their characteristics are determined for operation with a protecting activated fullerene coating. Our experiments indicate that such cathodes are promising for high-voltage electron devices operating in technical vacuum.

  6. Emittance measuring system on the UNILAC

    International Nuclear Information System (INIS)

    Ehrich, A.; Glatz, J.; Strahl, P.

    A description is given of one of the beam emittance measuring systems designed for the UNILAC at GSI. The measuring system mechanics and the detector system are detailed, and the associated electronics are discussed. Computer programming and data processing and evaluation are described

  7. Emittance growth rates for displaced beams

    International Nuclear Information System (INIS)

    Anderson, O.A.

    1993-05-01

    Emittance growth rates have been previously analyzed for nonuniform beams in linear channels and for initially uniform mismatched beams in nonlinear channels. These studies were for centered beams. Additional emittance growth can arise in cases where the beam is initially displaced. The purpose of this study is to obtain growth rates for displaced beams. This work differs from studies involving random displacement of electrodes. Our analysis assumes instead that the focusing system is perfectly aligned but that the beam is initially displaced with respect to the equilibrium axis. If the focusing force is slightly nonlinear, we find a gradual transfer of the potential energy of beam displacement into kinetic energy associated with emittance growth. We present explicit results for the emittance growth distance as a function of the nonlinearity of the channel. These results will have practical importance for designers of accelerators and transport systems when setting realistic tolerances for initial beam alignment. These tolerances will depend on the nonlinearity and the length of the system

  8. Aluminum oxide film thickness and emittance

    International Nuclear Information System (INIS)

    Thomas, J.K.; Ondrejcin, R.S.

    1991-11-01

    Aluminum reactor components which are not actively cooled could be subjected to high temperatures due to gamma heating after the core coolant level dropped during the ECS phase of a hypothetical LOCA event. Radiative heat transfer is the dominant heat transfer process in this scenario and therefore the emittance of these components is of interest. Of particular interest are the safety rod thimbles and Mark 60B blanket assemblies; for the K Reactor, these components have been exposed to low temperature (< 55 degrees C) moderator for about a year. The average moderator temperature was assumed to be 30 degrees C. The Al oxide film thickness at this temperature, after one year of exposure, is predicted to be 6.4 μm ± 10%; insensitive to exposure time. Dehydration of the film during the gamma heating accident would result in a film thickness of 6.0 μm ± 11%. Total hemispherical emittance is predicted to be 0.69 at 96 degrees C, decreasing to 0.45 at 600 degrees C. Some phenomena which would tend to yield thicker oxide films in the reactor environment relative to those obtained under experimental conditions were neglected and the predicted film thickness values are therefore conservative. The emittance values predicted for a given film thickness are also conservative. The conservativisms inherent in the predicted emittance are particularly relevant for uncertainty analysis of temperatures generated using these values

  9. Low Cost Constant – Head Drip Irrigation Emitter for Climate ...

    African Journals Online (AJOL)

    Low Cost Constant – Head Drip Irrigation Emitter for Climate Change Adaptation in Nigeria: Engineering Design and Calibration. ... The drip system comprises of abarrel, sub-main line, lateral lines, tubes and emitters, it can irrigate140 crop ...

  10. A method for implementation of nutritional therapy in hospitals

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Højgaard; Kondrup, Jens; Staun, Michael

    2006-01-01

    Background & aims: Many barriers make implementation of nutritional therapy difficult in hospitals. In this study we investigated whether, a targeted plan made by the staff in different departments could improve nutritional treatment within selected quality goals based on the ESPEN screening guid...... included consecutively. Mann-Whitney and Kruskal-Wallis test was used for ordinal data, and Pearson x2 test for nominative data. P values

  11. [New methods of patient selection for improved anticholinergic therapy].

    Science.gov (United States)

    Neuhaus, J; Schwalenberg, T; Schlichting, N; Schulze, M; Horn, L-C; Stolzenburg, J-U

    2007-09-01

    M3-specific inhibitors are currently preferred for anticholinergic therapy of OAB. However, not all of the patients profit from this regimen. This might reflect a heterogeneity of the patient group. The aim of this work is to define subgroups of patients with specific alterations of receptor expression and to profile the receptor expression individually. These receptor profiles might be used for the development of evidence-based "tailored" therapies. Detrusor probes from bladder carcinoma patients (BCa, n=9 F, n=7 male) and interstitial cystitis patients (IC, n=9 female) were examined using confocal immunofluorescence and PCR. M2, M3, P2X1-3, and H1-3 mRNAs were demonstrated in detrusor tissue. As revealed by immunofluorescence, the M2 receptor expression was significantly higher in female compared to male BCa tissues. In addition, the M2 receptor was further upregulated in IC vs BCa in female detrusor. IC patients showed specific alterations of their receptor profile. Individual receptor profiles might be used to optimize medicinal therapies.

  12. Finite-element modeling of spontaneous emission of a quantum emitter at nanoscale proximity to plasmonic waveguides

    DEFF Research Database (Denmark)

    Chen, Yuntian; Nielsen, Torben Roland; Gregersen, Niels

    2010-01-01

    of the plasmonic waveguide can be arbitrary. The fraction of the energy coupled to the plasmonic mode can be calculated exactly, which can be used to determine the efficiency with which single optical plasmons are generated. We apply our numerical method to calculate the coupling of a quantum emitter......We develop a self-consistent finite-element method to quantitatively study spontaneous emission from emitters in nanoscale proximity of plasmonic waveguides. In the model, it is assumed that only one guided mode is dominatingly excited by the quantum emitter, while the cross section...

  13. Test results on two thermionic converters with cermet emitters

    International Nuclear Information System (INIS)

    Saunders, M.; Danielson, L.; Huffman, F.

    1983-01-01

    An emitter made of a directionally solidified Mo-Al 2 O 3 , Cr 2 O 3 eutectic was provided by Eindhoven University of Technology in Eindhoven, The Netherlands. Although the high temperature braze cycle used in bonding this electrode to the emitter substrate destroyed its characteristic needle microstructure, the converter gave good performance. Apparently, chemical species evaporated from the emitter onto the collector provided a low collector work function. The resulting low barrier indices suggest that this surface is a promising emitter

  14. Effective source size, radial, angular and energy spread of therapeutic 11C positron emitter beams produced by 12C fragmentation

    Science.gov (United States)

    Lazzeroni, Marta; Brahme, Anders

    2014-02-01

    The use of positron emitter light ion beams in combination with PET (Positron Emission Tomography) and PET-CT (Computed Tomography) imaging could significantly improve treatment verification and dose delivery imaging during radiation therapy. The present study is dedicated to the analysis of the beam quality in terms of the effective source size, as well as radial, angular and energy spread of the 11C ion beam produced by projectile fragmentation of a primary point monodirectional and monoenergetic 12C ion beam in a dedicated range shifter of different materials. This study was performed combining analytical methods describing the transport of particles in matter and the Monte Carlo code SHIELD-HIT+. A high brilliance and production yield of 11C fragments with a small effective source size and emittance is best achieved with a decelerator made of two media: a first liquid hydrogen section of about 20 cm followed by a hydrogen rich section of variable length. The calculated intensity of the produced 11C ion beam ranges from about 5% to 8% of the primary 12C beam intensity depending on the exit energy and the acceptance of the beam transport system. The angular spread is lower than 1 degree for all the materials studied, but the brilliance of the beam is the highest with the proposed mixed decelerator.

  15. Surface-conduction electron-emitter characteristics and fabrication based on vertically aligned carbon nanotube arrays

    Energy Technology Data Exchange (ETDEWEB)

    Shih, Yi-Ting [Graduate Institute of Electro-Optical Engineering, National Taiwan University of Science and Technology, No. 43, Section 4, Keelung Road, Taipei 10607, Taiwan (China); Li, Kuan-Wei [Department of Electronic and Computer Engineering, National Taiwan University of Science and Technology, No. 43, Section 4, Keelung Road, Taipei 10607, Taiwan (China); Honda, Shin-ichi [Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280 (Japan); Lin, Pao-Hung; Huang, Ying-Sheng [Graduate Institute of Electro-Optical Engineering, National Taiwan University of Science and Technology, No. 43, Section 4, Keelung Road, Taipei 10607, Taiwan (China); Department of Electronic and Computer Engineering, National Taiwan University of Science and Technology, No. 43, Section 4, Keelung Road, Taipei 10607, Taiwan (China); Lee, Kuei-Yi, E-mail: kylee@mail.ntust.edu.tw [Graduate Institute of Electro-Optical Engineering, National Taiwan University of Science and Technology, No. 43, Section 4, Keelung Road, Taipei 10607, Taiwan (China); Department of Electronic and Computer Engineering, National Taiwan University of Science and Technology, No. 43, Section 4, Keelung Road, Taipei 10607, Taiwan (China)

    2017-06-01

    Graphical abstract: The pattern design provides a new structure of surface-conduction electron-emitter display (SED). Delta-star shaped vertically aligned CNT (VACNT) arrays with 20o tips can simultaneously provide three emitters to bombard the sides of equilateral triangles pattern of VACNT, which produces numerous secondary electrons and enhance the SED efficiency. - Highlights: • The carbon nanotube (CNT) has replaced palladium oxide (PdO) as the electrode material for surface-conduction electron-emitter (SCE) applications. • The vertically aligned CNT (VACNT) arrays with 20° tips of the delta-star arrangement are used as cathodes that easily emit electrons. The cathode pattern simultaneously provides three emitters to bombard the sides of equilateral triangles pattern of VACNT. • The VACNT arrays were covered with magnesium oxide (MgO) nanostructures to promote the surface-conduction electron-emitter display (SED) efficiency (η). • The η was stably maintained in the 75–85% range. The proposed design provides a facile new method for developing SED applications. - Abstract: The carbon nanotube (CNT) has replaced palladium oxide (PdO) as the electrode material for surface-conduction electron-emitter (SCE) applications. Vertically aligned CNT arrays with a delta-star arrangement were patterned and synthesized onto a quartz substrate using photolithography and thermal chemical vapor deposition. Delta-star shaped VACNT arrays with 20° tips are used as cathodes that easily emit electrons because of their high electrical field gradient. In order to improve the field emission and secondary electrons (SEs) in SCE applications, magnesium oxide (MgO) nanostructures were coated onto the VACNT arrays to promote the surface-conduction electron-emitter display (SED) efficiency (η). According to the definition of η in SCE applications, in this study, the η was stably maintained in the 75–85% range. The proposed design provides a facile new method for

  16. Determining the field emitter temperature during laser irradiation in the pulsed laser atom probe

    International Nuclear Information System (INIS)

    Kellogg, G.L.

    1981-01-01

    Three methods are discussed for determining the field emitter temperature during laser irradiation in the recently developed Pulsed Laser Atom Probe. A procedure based on the reduction of the lattice evaporation field with increasing emitter temperature is found to be the most convenient and reliable method between 60 and 500 K. Calibration curves (plots of the evaporation field versus temperature) are presented for dc and pulsed field evaporation of W, Mo, and Rh. These results show directly the important influence of the evaporation rate on the temperature dependence of the evaporation field. The possibility of a temperature calibration based on the ionic charge state distribution of field evaporated lattice atoms is also discussed. The shift in the charge state distributions which occurs when the emitter temperature is increased and the applied field strength is decreased at a constant rate of evaporation is shown to be due to the changing field and not the changing temperature. Nevertheless, the emitter temperature can be deduced from the charge state distribution for a specified evaporation rate. Charge state distributions as a function of field strength and temperature are presented for the same three materials. Finally, a preliminary experiment is reported which shows that the emitter temperature can be determined from field ion microscope observations of single atom surface diffusion over low index crystal planes. This last calibration procedure is shown to be very useful at higher temperatures (>600 K) where the other two methods become unreliable

  17. [Music therapy as an effective method of neurorehabilitation].

    Science.gov (United States)

    Yakupov, E Z; Nalbat, A V; Semenova, M V; Tlegenova, K A

    To assess the role of music therapy in the recovery of motor, speech and autonomic functions in patients with ischemic stroke (II). Forty-five patients with II in the middle cerebral artery were examined. The patients were randomized into three groups (main, comparison and control) of 15 individuals each. With patients of the first and the second groups on the 3rd, 5th, 7th and 9th days of the rehabilitation period the special set of exercises with music and without that respectively was fulfilled. The third group received a basic set of physical exercises (a control group).The third group was control. Dynamics of patients' state was estimated by the NIHSS, the Rivermead Mobility Index, the Action Research Arm Test and the modified scale for speech evaluation on the 2nd, 4th, 6th, 8th and 10th day of disease. A study of cardiorespiratory synchronization was conducted since the 6th day of stroke. The statistically significant efficacy of music therapy was shown for all parameters. The authors suggest that neuroplasticity may underlie the mechanisms of the programs used in the study.

  18. Oncothermia: a new paradigm and promising method in cancer therapies.

    Science.gov (United States)

    Hegyi, Gabriella; Szasz, Oliver; Szasz, Andras

    2013-01-01

    In "hypethermia", the procedure of raising the temperature of a part, or the whole body, up to 42 degrees C to kill cancer cells for a defined period of time is applied alone or as an adjunctive with various established cancer treatment modalities such as radiotherapy and chemotherapy. However, "hyperthermia" is not generally accepted as conventional therapy due to the complications of deep heating and lack of focusing of the heat effect only for malignant tissues. The idea of oncothermia solves the selective deep action on malignant tissue on nearly cellular level. Oncothermia is highly improved, safe and effective "hyperthermia" in clinical cancer therapy supported by in vivo, in vitro, and human research as shown in this article. Advantage of oncothermia: while the classical insufficiently, focused "hyperthermia" has to heat up in case of the multiple lesions overlapping all the volume, which contains both normal tissues and malignant tissues; while oncothermia automatically focuses on the malignant tissues in its multiple places, without treating the healthy tissue in between. The modulated radiofrequency current (RF) flows through the malignancies only. The radiofrequency modulated current with 13,56 MHz (fractal modulated) between 2 electrodes automatically focuses through malignant tissues with lower impedance and will flow mainly in the extracellular electrolyte because the normal cells are electronically isolated by their membrane by more than one-million V/m electrical field strength. Oncothermia today has the ability to be a candidate to a widely accepted modality of the standard cancer treatment.

  19. 2-D emittance equation with acceleration and compression

    International Nuclear Information System (INIS)

    Hahn, K.D.; Smith, L.

    1988-10-01

    Since both acceleration and compression are required for an Inertial Fusion Driver, the understanding of their effect on the beam quality, emittance, is important. This report attempts to generalize the usual emittance formula for the drifting beam to include these effects. The derivation of the 2-D emittance equation is carried out and a comparison with the particle code results is given. The 2-D emittance at a given axial location is reasonable to consider for a long beam, particularly with velocity tilt; transverse emittance averaged over the entire bunch is not a useful quantity. 6 refs., 2 figs., 1 tab

  20. Small horizontal emittance in the TESLA damping ring

    International Nuclear Information System (INIS)

    Decking, W.

    2001-01-01

    The present TESLA damping ring is designed for a normalized horizontal emittance of 8x10 -6 m. γ-γ collisions at the TESLA linear collider will benefit from a further decrease of the horizontal emittance. This paper reviews the processes which limit the horizontal emittance in the damping ring. Preliminary estimates on the smallest horizontal emittance for the present TESLA damping ring design as well as an ultimate limit of the emittance reachable with the TESLA damping ring concept will be given

  1. Ghost signals in Allison emittance scanners

    International Nuclear Information System (INIS)

    Stockli, Martin P.; Leitner, M.; Moehs, D.P.; Keller, R.; Welton, R.F.

    2004-01-01

    For over 20 years, Allison scanners have been used to measure emittances of low-energy ion beams. We show that scanning large trajectory angles produces ghost signals caused by the sampled beamlet impacting on an electric deflection plate. The ghost signal strength is proportional to the amount of beam entering the scanner. Depending on the ions, and their velocity, the ghost signals can have the opposite or the same polarity as the main beam signals. The ghost signals cause significant errors in the emittance estimates because they appear at large trajectory angles. These ghost signals often go undetected because they partly overlap with the real signals, are mostly below the 1% level, and often hide in the noise. A simple deflection plate modification is shown to reduce the ghost signal strength by over 99%

  2. Reducing longitudinal emittance growth in RFQ accelerators

    International Nuclear Information System (INIS)

    Koscielniak, S.

    1994-08-01

    Bunching and capture of a monochromatic beam into an rf bucket inevitably lead to substantial emittance growth through the mechanisms of filamentation and non-adiabatic variation of parameters. We describe a three step strategy for minimizing this growth, based on a clear understanding of the non-linear beam dynamics, and apply to acceleration of heavy ions with Z/A = 1/60 (and initial kinetic energy 60 keV/u) in a radio frequency quadrupole (RFQ) operating at 25 MHz. We also describe a scheme, to further reduce the emittance, based upon the use of an external RFQ-type prebuncher before the main accelerator. The external unit permits the bunching voltage to be reduced, to inject into a moving bucket, and to reduce the structure length. (author). 7 refs., 6 figs

  3. Emittance growth in coast in the SPS

    CERN Document Server

    Alekou, A; Bartosik, H; Calaga, R

    2017-01-01

    The CERN SPS will be used as a test-bed for the LHCprototype crab-cavities, which will be installed and testedin the SPS in 2018. As the time available for experimen-tal beam dynamics studies with the crab cavities installedin the machine will be limited, a very good preparation isrequired in advance. One of the main concerns is the in-duced emittance growth, driven by phase jitter in the crabcavities. In this respect, several machine development (MD)studies were performed during the past years to quantifyand characterize the emittance evolution of proton beamsin coast in the SPS. In these proceedings, the experimentalobservations from past years are summarized and the MDstudies from 2016 are presented. Finally, a proposal for anexperimental program for 2017 is discussed.

  4. Mesoscopic quantum emitters coupled to plasmonic nanostructures

    DEFF Research Database (Denmark)

    Andersen, Mads Lykke

    for the spontaneous emission of mesoscopic quantum emitters is developed. The light-matter interaction is in this model modied beyond the dipole expectancy and found to both suppress and enhance the coupling to plasmonic modes in excellent agreement with our measurements. We demonstrate that this mesoscopic effect......This thesis reports research on quantum dots coupled to dielectric and plasmonic nano-structures by way of nano-structure fabrication, optical measurements, and theoretical modeling. To study light-matter interaction, plasmonic gap waveguides with nanometer dimensions as well as samples for studies...... to allow for e- cient plasmon-based single-photon sources. Theoretical studies of coupling and propagation properties of plasmonic waveguides reveal that a high-refractive index of the medium surrounding the emitter, e.g. nGaAs = 3.5, limits the realizability of ecient plasmon-based single-photon sources...

  5. Ghost Signals In Allison Emittance Scanners

    International Nuclear Information System (INIS)

    Stockli, Martin P.; Leitner, M.; Keller, R.; Moehs, D.P.; Welton, R. F.

    2005-01-01

    For over 20 years, Allison scanners have been used to measure emittances of low-energy ion beams. We show that scanning large trajectory angles produces ghost signals caused by the sampled beamlet impacting on an electric deflection plate. The ghost signal strength is proportional to the amount of beam entering the scanner. Depending on the ions, and their velocity, the ghost signals can have the opposite or the same polarity as the main beam signals. The ghost signals cause significant errors in the emittance estimates because they appear at large trajectory angles. These ghost signals often go undetected because they partly overlap with the real signals, are mostly below the 1% level, and often hide in the noise. A simple deflection plate modification is shown to reduce the ghost signal strength by over 99%

  6. Photonic Crystal Emitters for Thermophotovoltaic Energy Conversion

    International Nuclear Information System (INIS)

    Stelmakh, Veronika; Chan, Walker R; Joannopoulos, John D; Celanovic, Ivan; Ghebrebrhan, Michael; Soljacic, Marin

    2015-01-01

    This paper reports the design, fabrication, and characterization of 2D photonic crystal (PhC) thermal emitters for a millimeter-scale hydrocarbon TPV microgenerator as a possible replacement for batteries in portable microelectronics, robotics, etc. In our TPV system, combustion heats a PhC emitter to incandescence and the resulting radiation is converted by a low-bandgap TPV cell. The PhC tailors the photonic density of states to produce spectrally confined thermal emission that matches the bandgap of the TPV cell, enabling high heat-to-electricity conversion efficiency. The work builds on a previously developed fabrication process to produce a square array of cylindrical cavities in a metal substrate. We will present ongoing incremental improvements in the optical and thermo-mechanical properties, the fabrication process, and the system integration, as recently combined with fabrication using novel materials, such as sputtered coatings, to enable a monolithic system. (paper)

  7. Repeated dose titration versus age-based method in electroconvulsive therapy: a pilot study

    NARCIS (Netherlands)

    Aten, J.J.; Oudega, M.L.; van Exel, E.; Stek, M.L.; van Waarde, J.A.

    2015-01-01

    In electroconvulsive therapy (ECT), a dose titration method (DTM) was suggested to be more individualized and therefore more accurate than formula-based dosing methods. A repeated DTM (every sixth session and dose adjustment accordingly) was compared to an age-based method (ABM) regarding treatment

  8. Modified theoretical minimum emittance lattice for an electron storage ring with extreme-low emittance

    Directory of Open Access Journals (Sweden)

    Yi Jiao

    2011-05-01

    Full Text Available In the continuing efforts to reduce the beam emittance of an electron storage ring composed of theoretical minimum emittance (TME lattice, down to a level of several tens of picometers, nonlinear dynamics grows to be a great challenge to the performance of the storage ring because of the strong sextupoles needed to compensate for its large global natural chomaticities coupled with its small average dispersion function. To help in dealing with the challenge of nonlinear optimization, we propose a novel variation of theoretical minimum emittance (TME lattice, named as “modified-TME” lattice, with minimal emittance about 3 times of the exact theoretical minimum, while with more compact layout, lower phase advance per cell, smaller natural chromaticities, and more relaxed optical functions than that in a TME cell, by using horizontally defocusing quadrupole closer to the dipole or simply combined-function dipole with horizontally defocusing gradient. We present approximate scaling formulas to describe the relationships of the design parameters in a modified-TME cell. The applications of modified-TME lattice in the PEP-X storage ring design are illustrated and the proposed lattice appears a good candidate for synchrotron radiation light source with extremely low emittance.

  9. Arc-textured metal surfaces for high thermal emittance space radiators

    International Nuclear Information System (INIS)

    Banks, B.A.; Rutledge, S.K.; Mirtich, M.J.; Behrend, T.; Hotes, D.; Kussmaul, M.; Barry, J.; Stidham, C.; Stueber, T.; DiFilippo, F.

    1994-01-01

    Carbon arc electrical discharges struck across the surfaces of metals such as Nb-1% Zr, alter the morphology to produce a high thermal emittance surface. Metal from the surface and carbon from the arc electrode vaporize during arcing, and then condense on the metal surface to produce a microscopically rough surface having a high thermal emittance. Quantitative spectral reflectance measurements from 0.33 to 15 μm were made on metal surfaces which were carbon arc treated in an inert gas environment. The resulting spectral reflectance data were then used to calculate thermal emittance as a function of temperature for various methods of arc treatment. The results of arc treatment on various metals are presented for both ac and dc arcs. Surface characterization data, including thermal emittance as a function of temperature, scanning electron microscopy, and atomic oxygen durability, are also presented. Ac arc texturing was found to increase the thermal emittance at 800 K from 0.05. to 0.70

  10. DNA damage by Auger emitters

    International Nuclear Information System (INIS)

    Martin, R.F.; d'Cunha, Glenn; Gibbs, Richard; Murray, Vincent; Pardee, Marshall; Allen, B.J.

    1988-01-01

    125 I atoms can be introduced at specific locations along a defined DNA target molecule, either by site-directed incorporation of an 125 I-labelled deoxynucleotide or by binding of an 125 I-labelled sequence-selective DNA ligand. After allowing accumulation of 125 I decay-induced damage to the DNA, application of DNA sequencing techniques enables positions of strand breaks to be located relative to the site of decay, at a resolution corresponding to the distance between adjacent nucleotides [0.34 nm]. Thus, DNA provides a molecular framework to analyse the extent of damage following [averaged] individual decay events. Results can be compared with energy deposition data generated by computer-simulation methods developed by Charlton et al. The DNA sequencing technique also provides information about the chemical nature of the termini of the DNA chains produced following Auger decay-induced damage. In addition to reviewing the application of this approach to the analysis of 125 I decay induced DNA damage, some more recent results obtained by using 67 Ga are also presented. (author)

  11. Parametric emittance measurements of electron beams produced by a laser plasma accelerator

    Science.gov (United States)

    Barber, S. K.; van Tilborg, J.; Schroeder, C. B.; Lehe, R.; Tsai, H.-E.; Swanson, K. K.; Steinke, S.; Nakamura, K.; Geddes, C. G. R.; Benedetti, C.; Esarey, E.; Leemans, W. P.

    2018-05-01

    Laser plasma accelerators (LPA) offer an exciting possibility to deliver high energy, high brightness electrons beams in drastically smaller distance scales than is typical for conventional accelerators. As such, LPAs draw considerable attention as potential drivers for next generation light sources and for a compact linear collider. In order to asses the viability of an LPA source for a particular application, the brightness of the source should be properly characterized. In this paper, we present charge dependent transverse emittance measurements of LPA sources using both ionization injection and shock induced density down ramp injection, with the latter delivering smaller transverse emittances by a factor of two when controlling for charge density. The single shot emittance method is described in detail with a discussion on limitations related to second order transport effects. The direct role of space charge is explored through a series of simulations and found to be consistent with experimental observations.

  12. Low-emittance tuning of storage rings using normal mode beam position monitor calibration

    Directory of Open Access Journals (Sweden)

    A. Wolski

    2011-07-01

    Full Text Available We describe a new technique for low-emittance tuning of electron and positron storage rings. This technique is based on calibration of the beam position monitors (BPMs using excitation of the normal modes of the beam motion, and has benefits over conventional methods. It is relatively fast and straightforward to apply, it can be as easily applied to a large ring as to a small ring, and the tuning for low emittance becomes completely insensitive to BPM gain and alignment errors that can be difficult to determine accurately. We discuss the theory behind the technique, present some simulation results illustrating that it is highly effective and robust for low-emittance tuning, and describe the results of some initial experimental tests on the CesrTA storage ring.

  13. Low-emittance tuning of storage rings using normal mode beam position monitor calibration

    Science.gov (United States)

    Wolski, A.; Rubin, D.; Sagan, D.; Shanks, J.

    2011-07-01

    We describe a new technique for low-emittance tuning of electron and positron storage rings. This technique is based on calibration of the beam position monitors (BPMs) using excitation of the normal modes of the beam motion, and has benefits over conventional methods. It is relatively fast and straightforward to apply, it can be as easily applied to a large ring as to a small ring, and the tuning for low emittance becomes completely insensitive to BPM gain and alignment errors that can be difficult to determine accurately. We discuss the theory behind the technique, present some simulation results illustrating that it is highly effective and robust for low-emittance tuning, and describe the results of some initial experimental tests on the CesrTA storage ring.

  14. Multi-component Lattice Boltzmann simulation of the hydrodynamics in drip emitters

    Directory of Open Access Journals (Sweden)

    Giacomo Falcucci

    2017-09-01

    Full Text Available In this paper, we propose a fast and efficient numerical technique based on the Lattice Boltzmann method (LBM to model the flow through a reference drip emitter geometry. The aim of the study is to demonstrate the applicability of the LBM as a reliable simulation tool for the hydraulic optimisation of irrigation systems. Results for the water flow through a rectangular drip emitter are in good agreement with literature numerical and experimental data. Furthermore, we demonstrate the feasibility of the proposed model to simulate a multi-component flow that could be used to simulate the presence of additives, contaminants, and suspended particles.

  15. Vertically aligned carbon nanotube emitter on metal foil for medical X-ray imaging.

    Science.gov (United States)

    Ryu, Je Hwang; Kim, Wan Sun; Lee, Seung Ho; Eom, Young Ju; Park, Hun Kuk; Park, Kyu Chang

    2013-10-01

    A simple method is proposed for growing vertically aligned carbon nanotubes on metal foil using the triode direct current plasma-enhanced chemical vapor deposition (PECVD). The carbon nanotube (CNT) electron emitter was fabricated using fewer process steps with an acid treated metal substrate. The CNT emitter was used for X-ray generation, and the X-ray image of mouse's joint was obtained with an anode current of 0.5 mA at an anode bias of 60 kV. The simple fabrication of a well-aligned CNT with a protection layer on metal foil, and its X-ray application, were studied.

  16. Development and application of an emitter for research of an on-board ultraviolet polarimeter

    Science.gov (United States)

    Nevodovskyi, P. V.; Geraimchuk, M. D.; Vidmachenko, A. P.; Ivakhiv, O. V.

    2018-05-01

    In carrying out of the work a layout of on-board small-sized ultraviolet polarimeter (UVP) was created. UVP is the device, which provides an implementation of passive remote studies of stratospheric aerosol from the board of the microsatellite of the Earth by the method of polarimetry. For carrying out of tests and the research of polarimetric equipment, a special stand was created at MAO of NAS of Ukraine. In its composition is an ultraviolet emitter. Emitter is one of the main components of a special stand for the study of on-board ultraviolet polarimeters.

  17. High brightness fiber laser pump sources based on single emitters and multiple single emitters

    Science.gov (United States)

    Scheller, Torsten; Wagner, Lars; Wolf, Jürgen; Bonati, Guido; Dörfel, Falk; Gabler, Thomas

    2008-02-01

    Driven by the potential of the fiber laser market, the development of high brightness pump sources has been pushed during the last years. The main approaches to reach the targets of this market had been the direct coupling of single emitters (SE) on the one hand and the beam shaping of bars and stacks on the other hand, which often causes higher cost per watt. Meanwhile the power of single emitters with 100μm emitter size for direct coupling increased dramatically, which also pushed a new generation of wide stripe emitters or multi emitters (ME) of up to 1000μm emitter size respectively "minibars" with apertures of 3 to 5mm. The advantage of this emitter type compared to traditional bars is it's scalability to power levels of 40W to 60W combined with a small aperture which gives advantages when coupling into a fiber. We show concepts using this multiple single emitters for fiber coupled systems of 25W up to 40W out of a 100μm fiber NA 0.22 with a reasonable optical efficiency. Taking into account a further efficiency optimization and an increase in power of these devices in the near future, the EUR/W ratio pushed by the fiber laser manufacturer will further decrease. Results will be shown as well for higher power pump sources. Additional state of the art tapered fiber bundles for photonic crystal fibers are used to combine 7 (19) pump sources to output powers of 100W (370W) out of a 130μm (250μm) fiber NA 0.6 with nominal 20W per port. Improving those TFB's in the near future and utilizing 40W per pump leg, an output power of even 750W out of 250μm fiber NA 0.6 will be possible. Combined Counter- and Co-Propagated pumping of the fiber will then lead to the first 1kW fiber laser oscillator.

  18. Ancient Chinese Fangzhongshu (Sexual Skills and Methods Therapy for Premature Ejaculation

    Directory of Open Access Journals (Sweden)

    Yong Zhu

    2016-12-01

    Full Text Available Premature ejaculation (PE is a common male sexual dysfunction that can have significant effects on a couple’s relationship. Behavioral therapy and psychotherapy are both safe and effective methods of treating PE. Ancient Chinese fangzhongshu (sexual skills and methods, which reflects a summary of expert experiences in sexology, contains many therapies for sexual dysfunction that are similar to those used in behavioral therapy or psychotherapy. A brief introduction dealing with the latest definitions of PE and treatment strategies drawn from behavioral therapy and psychotherapy is provided. Typical therapies for PE from ancient Chinese fangzhongshu are listed and briefly analyzed in order to define their domain of applicability and instructions for use. Ancient Chinese fangzhongshu contains many effective and safe therapies for PE. It should be incorporated into modern medical practice after critical analysis, and its scientific aspects should be promoted as a way of improving reproductive health, both to benefit individuals affected by PE and to promote traditional Chinese culture. Based on an analysis of the condition of the individual patient, one or multiple therapies guided by fangzhongshu can be expected to have an effect on the patient. Ancient Chinese fangzhongshu is of great value and should to be popularized and applied as a remedy for PE.

  19. Problems in radiological protection involving alpha emitters in bone

    International Nuclear Information System (INIS)

    Dolphin, G.W.

    1976-01-01

    Quantitative dose/effect relationships for humans exposed to α emitters can only be established from data on humans exposed to this type of radiation. The risk of bone sarcoma from exposure to plutonium-239 may be established from the data on the human cases exposed to radium-226 either by consideration of the radiation dose to the osteoprogenitor cells or by use of the average bone dose together with a modifying factor to take into account the greater toxicity of plutonium relative to radium. The relative toxicity can be evaluated from the data on osteosarcoma incidence in animals. Both methods of risk estimation are given and criticised in the paper. In future recommendations, ICRP will not use the critical organ concept and the late effects from α emitters deposited in organs other than the bone will have to be taken into account in setting maximum permissible annual intakes. The implications of this and other proposed changes in ICRP concepts are discussed. (orig.) [de

  20. Longitudinal emittance blowup in the large hadron collider

    CERN Document Server

    Baudrenghien, P

    2013-01-01

    The Large Hadron Collider (LHC) relies on Landau damping for longitudinal stability. To avoid decreasing the stability margin at high energy, the longitudinal emittance must be continuously increased during the acceleration ramp. Longitudinal blowup provides the required emittance growth. The method was implemented through the summer of 2010. Band-limited RF phase-noise is injected in the main accelerating cavities during the whole ramp of about 11min. Synchrotron frequencies change along the energy ramp, but the digitally created noise tracks the frequency change. The position of the noise-band, relative to the nominal synchrotron frequency, and the bandwidth of the spectrum are set by pre-defined constants, making the diffusion stop at the edges of the demanded distribution. The noise amplitude is controlled by feedback using the measurement of the average bunch length. This algorithm reproducibly achieves the programmed bunch length of about 1.2ns, at flat top with low bunch-to-bunch scatter and provides a...

  1. Longitudinal emittance reduction in LEIR of ion beams for LHC

    CERN Document Server

    Angoletta, M E; Findlay, A; Hancock, S; Manglunki, D

    2014-01-01

    For the 2013 LHC ion run the anticipated request for batches from the PS Complex comprising four ion bunches spaced by 100 ns was changed to batches of two bunches spaced by 200 ns. This modified demand was met by suppressing a splitting step in the PS machine, but with the consequence of halving the longitudinal emittance required from LEIR. Thus NOMINAL Pb54+ beams from LEIR had to be delivered inside ~9 eVs to provide sufficient blow-up margin in the PS. Machine Development (MD) sessions were carried out in LEIR to investigate methods to satisfy these stricter requirements. Two main ingredients were found to reduce longitudinal emittance. The first and most important was to adjust carefully the frequency offset at capture in order to align the RF with the position where the beam is deposited by the electron cooling system prior to acceleration. The second ingredient was to reduce the final bucket area in order to reduce any residual filamentation during capture. This note documents the results obtaine...

  2. COMPARATIVE EFFECTIVENESS OF DIFFERENT METHODS OF CANDIDAL DYSBACTERIOSIS THERAPY

    Directory of Open Access Journals (Sweden)

    S.V. Nikolaeva

    2009-01-01

    Full Text Available The study of effectiveness of different methods of microbiological disorders correction in children after 3 years old with candidal dysbacteriosis are presented in this article. The study compared probiotical sour milk-made stuff («Actimel» and sour milk-made stuff, not fortified with probiotical cultures («Rastishka» and traditional kefir. It was shown that an inclusion of probiotical sour milkmade stuff in diet of children with candidal dysbacteriosis results in normalization of lacto- and bifidobacteria level and decreasing of Candida level.Key words: children, candidal dysbacteriosis, probiotics.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(6:31-35

  3. Criteria for emittance compensation in high-brightness photoinjectors

    Directory of Open Access Journals (Sweden)

    Chun-xi Wang

    2007-10-01

    Full Text Available A critical process in high-brightness photoinjectors is emittance compensation, which brings under control the correlated transverse emittance growth due to the linear space-charge force. Although emittance compensation has been used and studied for almost two decades, the exact criteria to achieve emittance compensation is not as clear as it should be. In this paper, a perturbative analysis of slice envelopes and emittance evolution close to any reference envelope is developed, via which space-charge and chromatic effects are investigated. A new criterion for emittance compensation is found, which is complementary to the well-known matching condition for the invariant envelope and agrees very well with simulations.

  4. Quantum efficiency and thermal emittance of metal photocathodes

    Directory of Open Access Journals (Sweden)

    David H. Dowell

    2009-07-01

    Full Text Available Modern electron beams have demonstrated the brilliance needed to drive free electron lasers at x-ray wavelengths with major advances occurring since the invention of the photocathode gun and the realization of emittance compensation. These state-of-the-art electron beams are now becoming limited by the intrinsic thermal emittance of the cathode. In both dc and rf photocathode guns details of the cathode emission physics strongly influence the quantum efficiency and the thermal emittance. Therefore improving cathode performance is essential to increasing the brightness of beams. It is especially important to understand the fundamentals of cathode quantum efficiency and thermal emittance. This paper investigates the relationship between the quantum efficiency and the thermal emittance for metal cathodes using the Fermi-Dirac model for the electron distribution. We use a consistent theory to derive the quantum efficiency and thermal emittance, and compare our results to those of others.

  5. The Quantum Efficiency and Thermal Emittance of Metal Photocathodes

    International Nuclear Information System (INIS)

    Dowell, D.

    2009-01-01

    Modern electron beams have demonstrated the brilliance needed to drive free electron lasers at x-ray wavelengths, with the principle improvements occurring since the invention of the photocathode gun. The state-of-the-art normalized emittance electron beams are now becoming limited by the thermal emittance of the cathode. In both DC and RF photocathode guns, details of the cathode emission physics strongly influence the quantum efficiency and the thermal emittance. Therefore improving cathode performance is essential to increasing the brightness of beams. It is especially important to understand the fundamentals of cathode quantum efficiency and thermal emittance. This paper investigates the relationship between the quantum efficiency and the thermal emittance of metal cathodes using the Fermi-Dirac model for the electron distribution. We derive the thermal emittance and its relationship to the quantum efficiency, and compare our results to those of others

  6. High efficiency direct thermal to electric energy conversion from radioisotope decay using selective emitters and spectrally tuned solar cells

    Science.gov (United States)

    Chubb, Donald L.; Flood, Dennis J.; Lowe, Roland A.

    1993-01-01

    Thermophotovoltaic (TPV) systems are attractive possibilities for direct thermal-to-electric energy conversion, but have typically required the use of black body radiators operating at high temperatures. Recent advances in both the understanding and performance of solid rare-earth oxide selective emitters make possible the use of TPV at temperatures as low as 1200K. Both selective emitter and filter system TPV systems are feasible. However, requirements on the filter system are severe in order to attain high efficiency. A thin-film of a rare-earth oxide is one method for producing an efficient, rugged selective emitter. An efficiency of 0.14 and power density of 9.2 W/KG at 1200K is calculated for a hypothetical thin-film neodymia (Nd2O3) selective emitter TPV system that uses radioisotope decay as the thermal energy source.

  7. High efficiency direct thermal to electric energy conversion from radioisotope decay using selective emitters and spectrally tuned solar cells

    International Nuclear Information System (INIS)

    Chubb, D.L.; Flood, D.J.; Lowe, R.A.

    1993-08-01

    Thermophotovoltaic (TPV) systems are attractive possibilities for direct thermal-to-electric energy conversion, but have typically required the use of black body radiators operating at high temperatures. Recent advances in both the understanding and performance of solid rare-earth oxide selective emitters make possible the use of TPV at temperatures as low as 1200K. Both selective emitter and filter system TPV systems are feasible. However, requirements on the filter system are severe in order to attain high efficiency. A thin-film of a rare-earth oxide is one method for producing an efficient, rugged selective emitter. An efficiency of 0.14 and power density of 9.2 W/KG at 1200K is calculated for a hypothetical thin-film neodymia (Nd2O3) selective emitter TPV system that uses radioisotope decay as the thermal energy source

  8. Dielectric optical antenna thermal emitters and metamaterials

    Science.gov (United States)

    Schuller, Jonathan Aaron

    Optical antennas are critical components in nanophotonics research due to their unparalleled ability to concentrate electromagnetic energy into nanoscale volumes. Researchers typically construct such antennas from wavelength-size metallic structures. However, recent research has begun to exploit the scattering resonances of high-permittivity particles to realize all-dielectric optical antennas, emitters, and metamaterials. In this thesis, we experimentally and theoretically characterize the resonant modes of subwavelength rod-shaped dielectric particles and demonstrate their use in negative index metamaterials and novel infrared light emitters. At mid-infrared frequencies, Silicon Carbide (SiC) is an ideal system for studying the behavior of dielectric optical antennas. At frequencies below the TO phonon resonance, SiC behaves like a dielectric with very large refractive index. Using infrared spectroscopy and analytical Mie calculations we show that individual rod-shaped SiC particles exhibit a multitude of resonant modes. Detailed investigations of these SiC optical antennas reveal a wealth of new physics and applications. We discuss the distinct electromagnetic field profile for each mode, and demonstrate that two of the dielectric-type Mie resonances can be combined in a particle array to form a negative index metamaterial. We further show that these particles can serve as "broadcasting" antennas. Using a custom-built thermal emission microscope we collect emissivity spectra from single SiC particles at elevated temperatures, highlighting their use as subwavelength resonant light emitters. Finally, we derive and verify a variety of general analytical results applicable to all cylindrical dielectric antennas.

  9. Dielectric Optical Antenna Emitters and Metamaterials

    Science.gov (United States)

    Schuller, Jon

    2009-03-01

    Optical antennas are critical components in nanophotonics research due to their unparalleled ability to concentrate electromagnetic energy into nanoscale volumes. Researchers typically construct such antennas from wavelength-size metallic structures. However, recent research has begun to exploit the scattering resonances of high-permittivity particles to realize all-dielectric optical antennas, emitters, and metamaterials. In this talk, we experimentally and theoretically characterize the resonant modes of subwavelength rod-shaped dielectric particles and demonstrate their use in negative index metamaterials and novel infrared light emitters. At mid-infrared frequencies, Silicon Carbide (SiC) is an ideal system for studying the behavior of dielectric optical antennas. At frequencies below the TO phonon resonance, SiC behaves like a dielectric with very large refractive index. Using infrared spectroscopy and analytical Mie calculations we show that individual rod-shaped SiC particles exhibit a multitude of resonant modes. Detailed investigations of these SiC optical antennas reveal a wealth of new physics and applications. We discuss the distinct electromagnetic field profile for each mode, and demonstrate that two of the dielectric-type Mie resonances can be combined in a particle array to form a negative index metamaterial [1]. We further show that these particles can serve as ``broadcasting'' antennas. Using a custom-built thermal emission microscope we collect emissivity spectra from single SiC particles at elevated temperatures, highlighting their use as subwavelength resonant light emitters. Finally, we derive and verify a variety of general analytical results applicable to all cylindrical dielectric antennas and discuss extensions of the demonstrated concepts to different materials systems and frequency regimes. [1] J.A. Schuller, et al., Phys. Rev. Lett. 99, 107401 (2007)

  10. Shielding system for the detection of radioisotopes gamma-rays emitters

    International Nuclear Information System (INIS)

    Nascimento Filho, V.F. do

    1983-01-01

    A shielding system for detection of radioisotopes gamma-rays emitters in samples of big volumes (plants, animals, soils) is presented. The detection between the beaker Marinelli and the glass tube (inside of the scintillator crystal well) is compared. The beaker Marinelli method allows a drastic reduction in the time detection of the sample. (M.A.C.) [pt

  11. Investigations on cermet electrodes for thermionic emitters

    International Nuclear Information System (INIS)

    Schmidt, D.; Nazare, S.

    1975-01-01

    Unstable Ba 2 CaWO 6 -W with their own supply of Ba, as well as stable UO 2 -Mo-emitter cermets that have to be operated with an external Ba-source, have been prepared by axial hot pressing. The relevant properties of these cermets such as electrical resistivity and thermal expansion are reported and compared with theoretical predictions. The electron emission of these materials is discussed on the basis of the surface films formed. It provides the basis for optimising the behavior of these materials

  12. Multi-channel polarized thermal emitter

    Science.gov (United States)

    Lee, Jae-Hwang; Ho, Kai-Ming; Constant, Kristen P

    2013-07-16

    A multi-channel polarized thermal emitter (PTE) is presented. The multi-channel PTE can emit polarized thermal radiation without using a polarizer at normal emergence. The multi-channel PTE consists of two layers of metallic gratings on a monolithic and homogeneous metallic plate. It can be fabricated by a low-cost soft lithography technique called two-polymer microtransfer molding. The spectral positions of the mid-infrared (MIR) radiation peaks can be tuned by changing the periodicity of the gratings and the spectral separation between peaks are tuned by changing the mutual angle between the orientations of the two gratings.

  13. High efficiency quasi-monochromatic infrared emitter

    Energy Technology Data Exchange (ETDEWEB)

    Brucoli, Giovanni; Besbes, Mondher; Benisty, Henri, E-mail: henri.benisty@institutoptique.fr; Greffet, Jean-Jacques [Laboratoire Charles Fabry, UMR 8501, Institut d’Optique, CNRS, Université Paris-Sud 11, 2, Avenue Augustin Fresnel, 91127 Palaiseau Cedex (France); Bouchon, Patrick; Haïdar, Riad [Office National d’Études et de Recherches Aérospatiales, Chemin de la Hunière, 91761 Palaiseau (France)

    2014-02-24

    Incandescent radiation sources are widely used as mid-infrared emitters owing to the lack of alternative for compact and low cost sources. A drawback of miniature hot systems such as membranes is their low efficiency, e.g., for battery powered systems. For targeted narrow-band applications such as gas spectroscopy, the efficiency is even lower. In this paper, we introduce design rules valid for very generic membranes demonstrating that their energy efficiency for use as incandescent infrared sources can be increased by two orders of magnitude.

  14. Longitudinal emittance measurement at the ATS

    International Nuclear Information System (INIS)

    Cottingame, W.B.; Cortez, J.H.; Higgins, W.W.; Sander, O.R.; Sandoval, D.P.

    1986-01-01

    With increasing brightness, beam diagnostic techniques requiring interception of the beam become impractical. For H - particle beams, solutions for this problem based on the phenomenon of photodissociation are now being investigated at the Los Alamos National Laboratory accelerator test stand (ATS). A laser can be used to selectively neutralize portions of the beam than can be characterized after the charged particles have been swept away. We have used this technique for measuring longitudinal emittance at the output of the ATS radio-frequency quadrupole

  15. Emittance growth from transient coherent synchrotron radiation

    International Nuclear Information System (INIS)

    Bohn, C.L.; Li, R.; Bisognano, J.J.

    1996-01-01

    If the energies of individual particles in a bunch change as the bunch traverses a bending system, even if it is achromatic, betatron oscillations can be excited. Consequently, the transverse emittance of the bunch will grow as it moves downstream. Short bunches may be particularly susceptible to emission of coherent synchrotron radiation which can act back on the particles to change their energies and trajectories. Because a bend spans a well-defined length and angle, the bunch-excited wakefield and its effect back on the bunch are inherently transient. We outline a recently developed theory of this effect and apply it to example bending systems

  16. Tolerances for the vertical emittance in damping rings

    International Nuclear Information System (INIS)

    Raubenheimer, T.O.

    1991-11-01

    Future damping rings for linear colliders will need to have very small vertical emittances. In the limit of low beam current, the vertical emittance is primarily determined by the vertical dispersion and the betatron coupling. In this paper, the contributions to these effects from random misalignments are calculated and tolerances are derived to limit the vertical emittance with a 95% confidence level. 10 refs., 5 figs

  17. Measurement of emittance of metal interface in molten salt

    International Nuclear Information System (INIS)

    Araki, N.; Makino, A.; Nakamura, Y.

    1995-01-01

    A new technique for measuring the total normal emittance of a metal in a semi-transparent liquid has been proposed and this technique has been applied to measure the emittance of stainless steel (SUS304), nickel, and gold in molten potassium nitrate KNO 3 . These emittance data are indispensable to analyzing the radiative heat transfer between a metal and a semitransparent liquid, such as a molten salt

  18. On the feasibility of sub-100 nm rad emittance measurement in plasma accelerators using permanent magnetic quadrupoles

    Science.gov (United States)

    Li, F.; Wu, Y. P.; Nie, Z.; Guo, B.; Zhang, X. H.; Huang, S.; Zhang, J.; Cheng, Z.; Ma, Y.; Fang, Y.; Zhang, C. J.; Wan, Y.; Xu, X. L.; Hua, J. F.; Pai, C. H.; Lu, W.; Gu, Y. Q.

    2018-01-01

    Low emittance (sub-100 nm rad) measurement of electron beams in plasma accelerators has been a challenging issue for a while. Among various measurement schemes, measurements based on single-shot quad-scan using permanent magnetic quadrupoles (PMQs) has been recently reported with emittance as low as ˜200 nm Weingartner (2012 Phys. Rev. Spec. Top. Accel. Beams 15 111302). However, the accuracy and reliability of this method have not been systematically analyzed. Such analysis is critical for evaluating the potential of sub-100 nm rad emittance measurement using any scheme. In this paper, we analyze the effects of various nonideal physical factors on the accuracy and reliability using the PMQ method. These factors include aberration induced by a high order field, PMQ misalignment and angular fluctuation of incoming beams. Our conclusions are as follows: (i) the aberrations caused by high order fields of PMQs are relatively weak for low emittance measurement as long as the PMQs are properly constructed. A series of PMQs were manufactured and measured at Tsinghua University, and using numerical simulations their high order field effects were found to be negligible . (ii) The largest measurement error of emittance is caused by the angular misalignment between PMQs. For low emittance measurement of ˜100 MeV beams, an angular alignment accuracy of 0.1° is necessary. This requirement can be eased for beams with higher energies. (iii) The transverse position misalignment of PMQs and angular fluctuation of incoming beams only cause a translational and rotational shift of measured signals, respectively, therefore, there is no effect on the measured value of emittance. (iv) The spatial resolution and efficiency of the detection system need to be properly designed to guarantee the accuracy of sub-100 nm rad emittance measurement.

  19. Improvement of electron emission characteristics of porous silicon emitter by using cathode reduction and electrochemical oxidation

    Energy Technology Data Exchange (ETDEWEB)

    Li, He; Wenjiang, Wang, E-mail: wwj@mail.xjtu.edu.cn; Xiaoning, Zhang

    2017-03-31

    Highlights: • An electron emitter based on porous silicon having the strong application potential was prepared in the studying. • A new simple and convenient post-treat technique was proposed to improve the electron emission properties of the PS emitter. • It demonstrated that the improving of the PS morphology and the oxygen distribution is very important to the PS emitter. - Abstract: A new simple and convenient post-treat technique combined the cathode reduction (CR) and electrochemical oxidation (ECO) was proposed to improve the electron emission properties of the surface-emitting cold cathodes based on the porous silicon (PS). It is demonstrated here that by introducing this new technique combined CR and ECO, the emission properties of the diode have been significantly improved than those as-prepared samples. The experimental results showed that the emission current densities and efficiencies of sample treated by CR were 62 μA/cm{sup 2} and 12.10‰, respectively, nearly 2 orders of magnitude higher than those of as-prepared sample. Furthermore, the CR-treated PS emitter shows higher repeatability and stability compared with the as-prepared PS emitter. The scanning electron microscope (SEM), atomic force microscope (AFM), energy dispersive spectrometer (EDS), furier transformed infrared (FTIR) spectroscopy results indicated that the improved mechanism is mainly due to the passivation of the PS, which not only improve the PS morphology by the passivation of the H{sup +} but also improve the uniformity of the oxygen content distribution in the whole PS layer. Therefore, the method combined the CR treatment and ECO is expected to be a valuable technique to enhance the electron emission characteristics of the PS emitter.

  20. Improvement of electron emission characteristics of porous silicon emitter by using cathode reduction and electrochemical oxidation

    International Nuclear Information System (INIS)

    Li, He; Wenjiang, Wang; Xiaoning, Zhang

    2017-01-01

    Highlights: • An electron emitter based on porous silicon having the strong application potential was prepared in the studying. • A new simple and convenient post-treat technique was proposed to improve the electron emission properties of the PS emitter. • It demonstrated that the improving of the PS morphology and the oxygen distribution is very important to the PS emitter. - Abstract: A new simple and convenient post-treat technique combined the cathode reduction (CR) and electrochemical oxidation (ECO) was proposed to improve the electron emission properties of the surface-emitting cold cathodes based on the porous silicon (PS). It is demonstrated here that by introducing this new technique combined CR and ECO, the emission properties of the diode have been significantly improved than those as-prepared samples. The experimental results showed that the emission current densities and efficiencies of sample treated by CR were 62 μA/cm"2 and 12.10‰, respectively, nearly 2 orders of magnitude higher than those of as-prepared sample. Furthermore, the CR-treated PS emitter shows higher repeatability and stability compared with the as-prepared PS emitter. The scanning electron microscope (SEM), atomic force microscope (AFM), energy dispersive spectrometer (EDS), furier transformed infrared (FTIR) spectroscopy results indicated that the improved mechanism is mainly due to the passivation of the PS, which not only improve the PS morphology by the passivation of the H"+ but also improve the uniformity of the oxygen content distribution in the whole PS layer. Therefore, the method combined the CR treatment and ECO is expected to be a valuable technique to enhance the electron emission characteristics of the PS emitter.

  1. Transverse beam emittance optimization for the injection into BESSY II

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, Felix [Helmholtz Zentrum Berlin, Institut Beschleunigerphysik (Germany); Humboldt-Universitaet zu Berlin, Institut fuer Physik (Germany)

    2016-07-01

    For top up injection into the storage ring BESSY II an average injection efficiency of at least 90% is required. In low alpha mode the injection efficiency does not meet the requirements. Future BESSY II features will include shorter bunches in the storage ring (VSR) and user transparent injection with a non linear kicker. These will raise the demands on the quality of the injected beam even further. This work investigates the development of transverse emittance over the acceleration cycle in the synchrotron and the possibility of transverse emittance exchange by a sequence of skew quadrupoles in the transfer line. Results of emittance measurements and emittance exchange simulations will be given.

  2. Emittance Growth during Bunch Compression in the CTF-II

    Energy Technology Data Exchange (ETDEWEB)

    Raubenheimer, Tor O

    1999-02-26

    Measurements of the beam emittance during bunch compression in the CLIC Test Facility (CTF-II) are described. The measurements were made with different beam charges and different energy correlations versus the bunch compressor settings which were varied from no compression through the point of full compression and to over-compression. Significant increases in the beam emittance were observed with the maximum emittance occurring near the point of full (maximal) compression. Finally, evaluation of possible emittance dilution mechanisms indicate that coherent synchrotron radiation was the most likely cause.

  3. Internal emitter dosimetry: are patient-specific calculations necessary?

    International Nuclear Information System (INIS)

    Sgouros, G.

    1996-01-01

    Full text: The question of whether patient-specific calculations are needed in internal emitter dosimetry arises when radionuclides are used for therapy. In diagnostic procedures the absorbed dose delivered to normal tissue is far below hazardous levels. In internal emitter therapy, the need for patient-specific dosimetry may arise if a large variability in biodistribution, normal tissue toxicity or efficacy is anticipated. Patient-specificity may be accomplished at the level of pharmacokinetics, anatomy/tumor-geometry or both. At the first level, information regarding the biodistribution of a particular radiolabeled agent is obtained and used to determine the maximum activity that may be administered for treatment. The classical example of this is radioiodine therapy for thyroid cancer. In radioiodine therapy, the therapy dose is preceded by a tracer dose of I-131-iodide which is used to measure patient kinetics by imaging and whole-body counting. Absorbed dose estimates obtained from these data are used to constrain the therapy dose to meet safety criteria established in a previously performed dose-response study. The most ambitious approach to patient-specific dosimetry, requires a three-dimensional set of images representing radionuclide distribution (SPECT or PET) and a corresponding set of registered images representing anatomy (CT or MRI). The spatial distribution of absorbed dose or dose-rate may then be obtained by convolution of a point-kernel with the radioactivity distribution or by Monte Carlo calculation. The spatial absorbed dose or dose-rate distribution may be represented as a set of images, as isodose contours, or as dose-volume histograms. The 3-D Monte Carlo approach is, in principle, the most patient-specific; it accounts for patient anatomy and tumor geometry as well as for the spatial distribution of radioactivity. It is also, however, the most logistically and technically demanding. Patients are required to undergo CT or MRI and at least one

  4. A Split-and-Merge-Based Uterine Fibroid Ultrasound Image Segmentation Method in HIFU Therapy.

    Directory of Open Access Journals (Sweden)

    Menglong Xu

    Full Text Available High-intensity focused ultrasound (HIFU therapy has been used to treat uterine fibroids widely and successfully. Uterine fibroid segmentation plays an important role in positioning the target region for HIFU therapy. Presently, it is completed by physicians manually, reducing the efficiency of therapy. Thus, computer-aided segmentation of uterine fibroids benefits the improvement of therapy efficiency. Recently, most computer-aided ultrasound segmentation methods have been based on the framework of contour evolution, such as snakes and level sets. These methods can achieve good performance, although they need an initial contour that influences segmentation results. It is difficult to obtain the initial contour automatically; thus, the initial contour is always obtained manually in many segmentation methods. A split-and-merge-based uterine fibroid segmentation method, which needs no initial contour to ensure less manual intervention, is proposed in this paper. The method first splits the image into many small homogeneous regions called superpixels. A new feature representation method based on texture histogram is employed to characterize each superpixel. Next, the superpixels are merged according to their similarities, which are measured by integrating their Quadratic-Chi texture histogram distances with their space adjacency. Multi-way Ncut is used as the merging criterion, and an adaptive scheme is incorporated to decrease manual intervention further. The method is implemented using Matlab on a personal computer (PC platform with Intel Pentium Dual-Core CPU E5700. The method is validated on forty-two ultrasound images acquired from HIFU therapy. The average running time is 9.54 s. Statistical results showed that SI reaches a value as high as 87.58%, and normHD is 5.18% on average. It has been demonstrated that the proposed method is appropriate for segmentation of uterine fibroids in HIFU pre-treatment imaging and planning.

  5. Radiation doses and risks from internal emitters

    International Nuclear Information System (INIS)

    Harrison, John; Day, Philip

    2008-01-01

    This review updates material prepared for the UK Government Committee Examining Radiation Risks from Internal Emitters (CERRIE) and also refers to the new recommendations of the International Commission on Radiological Protection (ICRP) and other recent developments. Two conclusions from CERRIE were that ICRP should clarify and elaborate its advice on the use of its dose quantities, equivalent and effective dose, and that more attention should be paid to uncertainties in dose and risk estimates and their implications. The new ICRP recommendations provide explanations of the calculation and intended purpose of the protection quantities, but further advice on their use would be helpful. The new recommendations refer to the importance of understanding uncertainties in estimates of dose and risk, although methods for doing this are not suggested. Dose coefficients (Sv per Bq intake) for the inhalation or ingestion of radionuclides are published as reference values without uncertainty. The primary purpose of equivalent and effective dose is to enable the summation of doses from different radionuclides and from external sources for comparison with dose limits, constraints and reference levels that relate to stochastic risks of whole-body radiation exposure. Doses are calculated using defined biokinetic and dosimetric models, including reference anatomical data for the organs and tissues of the human body. Radiation weighting factors are used to adjust for the different effectiveness of different radiation types, per unit absorbed dose (Gy), in causing stochastic effects at low doses and dose rates. Tissue weighting factors are used to take account of the contribution of individual organs and tissues to overall detriment from cancer and hereditary effects, providing a simple set of rounded values chosen on the basis of age- and sex-averaged values of relative detriment. While the definition of absorbed dose has the scientific rigour required of a basic physical quantity

  6. Dosimetry of internal emitters - quo vadis?

    International Nuclear Information System (INIS)

    Reddy, A.R.; Nagaratnam, A.; Jain, S.C.; Gupta, M.M.; Mehta, S.C.

    1999-01-01

    The dosimetry of internally administered radiopharmaceuticals in nuclear medicine procedures using MIRD formalisms and dosimetry in the case of intakes of radionuclides and ICRP methodology for the purpose of radiological protection are well established working practices. It should, however, be remembered that dose or dose coefficients calculated refer to a reference individual, defined in terms of a mathematical phantom established on the basis of certain biokinetic reference parameters. The reference individual represents a typical caucasian adult of West Europe or North American origin. Recently, some attempts have been made to define a Reference Asian and a Reference Indian individual and to assess the effects of anatomical differences and changes in the biokinetics of radiopharmaceuticals and other radionuclides in these different reference individuals on the estimation of dose and dose coefficients in relation to the intake of internal radionuclides. The assessment of doses to the embryo/fetus due to intake of radionuclides by pregnant women, local dose estimates, microdosimetry, radiobiology and radiation protection aspects relating to Auger electron emitters represent other areas of active research in the area of dosimetry of internal emitters. The present review summarises these different aspects of work. (orig.) [de

  7. Barium depletion in hollow cathode emitters

    International Nuclear Information System (INIS)

    Polk, James E.; Mikellides, Ioannis G.; Katz, Ira; Capece, Angela M.

    2016-01-01

    Dispenser hollow cathodes rely on a consumable supply of Ba released by BaO-CaO-Al 2 O 3 source material in the pores of a tungsten matrix to maintain a low work function surface. The examination of cathode emitters from long duration tests shows deposits of tungsten at the downstream end that appear to block the flow of Ba from the interior. In addition, a numerical model of Ba transport in the cathode plasma indicates that the Ba partial pressure in the insert may exceed the equilibrium vapor pressure of the dominant Ba-producing reaction, and it was postulated previously that this would suppress Ba loss in the upstream part of the emitter. New measurements of the Ba depletion depth from a cathode insert operated for 8200 h reveal that Ba loss is confined to a narrow region near the downstream end, confirming this hypothesis. The Ba transport model was modified to predict the depletion depth with time. A comparison of the calculated and measured depletion depths gives excellent qualitative agreement, and quantitative agreement was obtained assuming an insert temperature 70 °C lower than measured beginning-of-life values

  8. Emittance growth of bunched beams in bends

    International Nuclear Information System (INIS)

    Carlsten, B.E.; Raubenheimer, T.O.

    1995-01-01

    Talman [Phys. Rev. Lett. 56, 1429 (1986)] has proposed a novel relativistic effect that occurs when a charged particle beam is bent in the magnetic field from an external dipole. The consequence of this effect is that the space-charge forces from the particles do not exhibit the usual inverse-square energy dependence and some part of them are, in fact, independent of energy. This led to speculation that this effect could introduce significant emittance growth for a bending electron beam. Subsequently, it was shown that this effect's influence on the beam's transverse motion is canceled for a dc beam by a potential depression within the beam (to first order in the beam radius divided by the bend radius). In this paper, we extend the analysis to include short bunch lengths (as compared to the beam pipe dimensions) and find that there is no longer the cancellation for forces both transverse to and in the direction of motion. We provide an estimate for the emittance growth as a function of bend angle, beam radius, and current, and for magnetic compression of an electron bunch

  9. Narrowband infrared emitters for combat ID

    Science.gov (United States)

    Pralle, Martin U.; Puscasu, Irina; Daly, James; Fallon, Keith; Loges, Peter; Greenwald, Anton; Johnson, Edward

    2007-04-01

    There is a strong desire to create narrowband infrared light sources as personnel beacons for application in infrared Identify Friend or Foe (IFF) systems. This demand has augmented dramatically in recent years with the reports of friendly fire casualties in Afghanistan and Iraq. ICx Photonics' photonic crystal enhanced TM (PCE TM) infrared emitter technology affords the possibility of creating narrowband IR light sources tuned to specific IR wavebands (near 1-2 microns, mid 3-5 microns, and long 8-12 microns) making it the ideal solution for infrared IFF. This technology is based on a metal coated 2D photonic crystal of air holes in a silicon substrate. Upon thermal excitation the photonic crystal modifies the emitted yielding narrowband IR light with center wavelength commensurate with the periodicity of the lattice. We have integrated this technology with microhotplate MEMS devices to yield 15mW IR light sources in the 3-5 micron waveband with wall plug efficiencies in excess of 10%, 2 orders of magnitude more efficient that conventional IR LEDs. We have further extended this technology into the LWIR with a light source that produces 9 mW of 8-12 micron light at an efficiency of 8%. Viewing distances >500 meters were observed with fielded camera technologies, ideal for ground to ground troop identification. When grouped into an emitter panel, the viewing distances were extended to 5 miles, ideal for ground to air identification.

  10. Compact Rare Earth Emitter Hollow Cathode

    Science.gov (United States)

    Watkins, Ronald; Goebel, Dan; Hofer, Richard

    2010-01-01

    A compact, high-current, hollow cathode utilizing a lanthanum hexaboride (LaB6) thermionic electron emitter has been developed for use with high-power Hall thrusters and ion thrusters. LaB6 cathodes are being investigated due to their long life, high current capabilities, and less stringent xenon purity and handling requirements compared to conventional barium oxide (BaO) dispenser cathodes. The new cathode features a much smaller diameter than previously developed versions that permit it to be mounted on axis of a Hall thruster ( internally mounted ), as opposed to the conventional side-mount position external to the outer magnetic circuit ("externally mounted"). The cathode has also been reconfigured to be capable of surviving vibrational loads during launch and is designed to solve the significant heater and materials compatibility problems associated with the use of this emitter material. This has been accomplished in a compact design with the capability of high-emission current (10 to 60 A). The compact, high-current design has a keeper diameter that allows the cathode to be mounted on the centerline of a 6- kW Hall thruster, inside the iron core of the inner electromagnetic coil. Although designed for electric propulsion thrusters in spacecraft station- keeping, orbit transfer, and interplanetary applications, the LaB6 cathodes are applicable to the plasma processing industry in applications such as optical coatings and semiconductor processing where reactive gases are used. Where current electrical propulsion thrusters with BaO emitters have limited life and need extremely clean propellant feed systems at a significant cost, these LaB6 cathodes can run on the crudest-grade xenon propellant available without impact. Moreover, in a laboratory environment, LaB6 cathodes reduce testing costs because they do not require extended conditioning periods under hard vacuum. Alternative rare earth emitters, such as cerium hexaboride (CeB6) can be used in this

  11. Effectiveness of cognitive behavioral therapy integrated with systematic desensitization, cognitive behavioral therapy combined with eye movement desensitization and reprocessing therapy, and cognitive behavioral therapy combined with virtual reality exposure therapy methods in the treatment of flight anxiety: a randomized trial.

    Science.gov (United States)

    Triscari, Maria Teresa; Faraci, Palmira; Catalisano, Dario; D'Angelo, Valerio; Urso, Viviana

    2015-01-01

    The purpose of the research was to compare the effectiveness of the following treatment methods for fear of flying: cognitive behavioral therapy (CBT) integrated with systematic desensitization, CBT combined with eye movement desensitization and reprocessing therapy, and CBT combined with virtual reality exposure therapy. Overall, our findings have proven the efficacy of all interventions in reducing fear of flying in a pre- to post-treatment comparison. All groups showed a decrease in flight anxiety, suggesting the efficiency of all three treatments in reducing self-report measures of fear of flying. In particular, our results indicated significant improvements for the treated patients using all the treatment programs, as shown not only by test scores but also by participation in the post-treatment flight. Nevertheless, outcome measures maintained a significant effect at a 1-year follow-up. In conclusion, combining CBT with both the application of eye movement desensitization and reprocessing treatment and the virtual stimuli used to expose patients with aerophobia seemed as efficient as traditional cognitive behavioral treatments integrated with systematic desensitization.

  12. Measurement of X-ray beam emittance using crystal optics at an X-ray undulator beamline

    International Nuclear Information System (INIS)

    Kohmura, Yoshiki; Suzuki, Yoshio; Awaji, Mitsuhiro; Tanaka, Takashi; Hara, Toru; Goto, Shunji; Ishikawa, Tetsuya

    2000-01-01

    We present a method of using crystal optics to measure the emittance of the X-ray source. Two perfect crystals set in (++) configuration work as a high-resolution collimator. The phase-space diagram (i.e. beam cross-section and angular distribution) could be determined without any assumptions on the light source. When the measurement is done at short wavelength radiation from undulator, the electron beam emittance is larger than the diffraction limit of the X-rays. Therefore, the electron beam emittance could be estimated. The measurement was done with the hard X-rays of 18.5 and 55 keV from an undulator beamline, BL 47XU, of SPring-8. The horizontal emittance of the X-ray beam was estimated to be about 7.6 nmrad, close to the designed electron beam emittance of the storage ring (7 nmrad). Some portions of the instrumental functions, such as the scattering by filters and windows along the beamline and the slight bent of the crystal planes of the monochromator, could not be precisely evaluated, but an upper limit for the vertical emittance of the electron beam could be obtained as 0.14 nmrad

  13. Interactive session: alpha emitters, fashion or reality? radionuclides and molecules availability

    International Nuclear Information System (INIS)

    Zimmermann, R.

    2015-01-01

    Full text of publication follows. This introduction to the interactive session will simply be based on statements related to the future of therapy in nuclear medicine with some emphasis on the use of alpha-emitters. Some hypotheses will be developed on topics such as 'How will look nuclear medicine in 2025?', 'Do we have enough information to support the use of alpha in therapy?' 'Does it make sense to develop alpha-labelled molecules without long term financial commitment?', 'Will sufficient amounts of radionuclides available when the drugs will be ready for marketing?', 'Do we know enough about alpha emitters toxicity?', 'Is personalized medicine really the solution of the future of health care?', 'How can we convince authorities about the advantages of alpha labelled molecules?', 'Is the development of alpha RIT more expensive or more difficult than beta RIT?', 'Where are all the beta-emitter under development gone?', 'With alpha-emitters, are we speaking about 2025 or 2050?', 'Will Xofigo be a success?', 'What will be the real role of pharmaceutical companies in radiotherapy?', 'Who are the most afraid about radioactivity, the patients or the authorities?'. The speaker will provide his own opinion about each topic. Will you agree or not with him? What is your opinion? (author)

  14. Dynamic Aperture Optimization for Low Emittance Light Sources

    CERN Document Server

    Kramer, Stephen L

    2005-01-01

    State of the art low emittance light source lattices, require small bend angle dipole magnets and strong quadrupoles. This in turn creates large chromaticity and small value of dispersion in the lattice. To counter the high chromaticity strong sextupoles are required which limit the dynamic aperture. Traditional methods for expanding the dynamic aperture use harmonic sextupoles to counter the tune shift with amplitude. This has been successful up to now, but is non-deterministic and limited as the sextupole strength increases, driving higher order nonlinearities. We have taken a different approach that makes use of the tune flexibility of a TBA lattice to minimize the lowest order nonlinearities, freeing the harmonic sextupoles to counter the higher order nonlinearities. This procedure is being used to improve the nonlinear dynamics of the NSLS-II lattice.

  15. Movement of Irrigation Water in Soil from a Surface Emitter

    Directory of Open Access Journals (Sweden)

    Ibrahim Abbas Dawood

    2016-09-01

    Full Text Available rickle irrigation is one of the most conservative irrigation techniques since it implies supplying water directly on the soil through emitters. Emitters dissipate energy of water at the end of the trickle irrigation system and provide water at emission points. The area wetted by an emitter depends upon the discharge of emitter, soil texture, initial soil water content, and soil permeability. The objectives of this research were to predict water distribution profiles through different soils for different conditions and quantify the distribution profiles in terms of main characteristics of soil and emitter. The wetting patterns were simulated at the end of each hour for a total time of application of 12 hrs, emitter discharges of 0.5, 0.75, 1, 2, 3, 4, and 5 lph, and five initial volumetric soil water contents. Simulation of water flow from a single surface emitter was carried out by using the numerically-based software Hydrus-2D/3D, Version 2.04. Two approaches were used in developing formulas to predict the domains of the wetted pattern. In order to verify the results obtained by implementing the software Hydrus-2D/3D a field experiment was conducted to measure the wetted diameter and compare measured values with simulated ones. The results of the research showed that the developed formulas to express the wetted diameter and depth in terms of emitter discharge, time of application, and initial soil water content are very general and can be used with very good accuracy.

  16. Coupling of Quantum Emitters in Nanodiamonds to Plasmonic Structures

    DEFF Research Database (Denmark)

    Kumar, Shailesh

    This PhD thesis describes work towards the enhancement and efficient channeling of photons emitted from a single photon emitter. The emitter used is a defect center, the Nitrogen-Vacancy (NV) center, in diamond. The NV-center has many unique properties, such as long coherence time of its electron...

  17. Emittance growth due to dipole ripple and sextupole

    International Nuclear Information System (INIS)

    Shih, H.J.; Ellison, J.A.; Syphers, M.J.; Newberger, B.S.

    1993-05-01

    Ripple in the power supplies for storage ring magnets can have adverse effects on the circulating beams: orbit distortion and emittance growth from dipole ripple, tune modulation and dynamic aperture reduction from quadrupole ripple, etc. In this paper, we study the effects of ripple in the horizontal bending field of the SSC in the presence of nonlinearity, in particular, the growth in beam emittance

  18. Emittance growth due to negative-mass instability above transition

    International Nuclear Information System (INIS)

    Ng, King-Yuen.

    1994-08-01

    Due to space-charge effect, there is a growth of bunch emittance across transition as a result of negative-mass instability. The models of growth at cutoff frequency and growth from high-frequency Schottky noise are reviewed. The difficulties of performing reliable simulations are discussed. An intuitive self-bunching model for estimating emittance growth is presented

  19. Emittance formula for slits and pepper-pot measurement

    International Nuclear Information System (INIS)

    Zhang, M.

    1996-10-01

    In this note, a rigid formula for slits and pepper-pot emittance measurement is derived. The derivation is based on the one- dimensional slit measurement setup. A mathematical generalization of the slit emittance formula to the pepper-pot measurement is discussed

  20. MEV Energy Electrostatic Accelerator Ion Beam Emittance Measurement

    OpenAIRE

    I.G. Ignat’ev; M.I. Zakharets; S.V. Kolinko; D.P. Shulha

    2014-01-01

    The testing equipment was designed, manufactured and tried out permitting measurements of total current, current profile and emittance of an ion beam extracted from the ion beam. MeV energy electrostatic accelerator ion H + beam emittance measurement results are presented.

  1. Measurement of the transverse emittance for the NSC Pelletron

    International Nuclear Information System (INIS)

    Rodriques, G.; Mandal, A.; Chopra, S.; Joshi, R.; Datta, S.K.; Roy, A.

    1998-01-01

    The knowledge of the emittance (transverse and longitudinal) of the NSC pelletron is essential for matching the acceptance of the LINAC which is to be installed to augment the pelletron beam energies. The transverse emittance of NSC pelletron has been measured by employing a focussing element and a down-stream beam profile monitor

  2. Jamming of Quantum Emitters by Active Coated Nanoparticles

    DEFF Research Database (Denmark)

    Arslanagic, Samel; Ziolkowski, Richard W.

    2013-01-01

    to effectively cloak the emitters to a far-field observer is reported and explained through thorough near- and far-field investigations. This property offers an interesting route toward the jamming of quantum emitters/nanoantennas that might be of potential use, for instance, in biological fluorescence assays...

  3. Low emittance lattices for electron storage rings revisited

    International Nuclear Information System (INIS)

    Trbojevic, D.; Courant, E.

    1994-01-01

    Conditions for the lowest possible emittance of the lattice for electron storage rings are obtained by a simplified analytical approach. Examples of electron storage lattices with minimum emittances are presented. A simple graphical presentation in the normalized dispersion space (Floquet's transformation) is used to illustrate the conditions and results

  4. Comparison of Three Methods of Reducing Test Anxiety: Systematic Desensitization, Implosive Therapy, and Study Counseling

    Science.gov (United States)

    Cornish, Richard D.; Dilley, Josiah S.

    1973-01-01

    Systematic desensitization, implosive therapy, and study counseling have all been effective in reducing test anxiety. In addition, systematic desensitization has been compared to study counseling for effectiveness. This study compares all three methods and suggests that systematic desentization is more effective than the others, and that implosive…

  5. Cost evaluation of two methods of post tooth extraction hemostasis in patients on anticoagulant therapy.

    Science.gov (United States)

    Zusman, S P; Lustig, J P; Bin Nun, G

    1993-06-01

    The classical management of patients on oral anticoagulant therapy included hospitalisation, cessation of the anticoagulant agent, and extraction of teeth when the prothrombine levels rise. This method was substituted in the High Risk Dental Clinic at Barzilai Medical Center in Ashkelon by use of a tissue sealant (Tisseel) which does not need hospitalisation nor cessation of the anticoagulant therapy. In comparing the last 23 sessions employing the former method to the first 23 sessions using the new method there were significant differences in the cost effectiveness for the health system, provider, insurer and patient. Despite the fact that from the health system point of view the new method is much more cost effective, there is no financial incentive for the provider (hospital) nor awareness on the part of the insurer (General Sick Fund) to embrace it and 'market' it.

  6. Evaluations of carbon nanotube field emitters for electron microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Nakahara, Hitoshi, E-mail: nakahara@nagoya-u.jp [Department of Quantum Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603 (Japan); Kusano, Yoshikazu; Kono, Takumi; Saito, Yahachi [Department of Quantum Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603 (Japan)

    2009-11-30

    Brightness of carbon nanotube (CNT) emitters was already reported elsewhere. However, brightness of electron emitter is affected by a virtual source size of the emitter, which strongly depends on electron optical configuration around the emitter. In this work, I-V characteristics and brightness of a CNT emitter are measured under a practical field emission electron gun (e-gun) configuration to investigate availability of CNT for electron microscopy. As a result, it is obtained that an emission area of MWNT is smaller than its tip surface area, and the emission area corresponds to a five-membered-ring with 2nd nearest six-membered-rings on the MWNT cap surface. Reduced brightness of MWNT is measured as at least 2.6x10{sup 9} A/m{sup 2} sr V. It is concluded that even a thick MWNT has enough brightness under a practical e-gun electrode configuration and suitable for electron microscopy.

  7. Evaluations of carbon nanotube field emitters for electron microscopy

    Science.gov (United States)

    Nakahara, Hitoshi; Kusano, Yoshikazu; Kono, Takumi; Saito, Yahachi

    2009-11-01

    Brightness of carbon nanotube (CNT) emitters was already reported elsewhere. However, brightness of electron emitter is affected by a virtual source size of the emitter, which strongly depends on electron optical configuration around the emitter. In this work, I- V characteristics and brightness of a CNT emitter are measured under a practical field emission electron gun (e-gun) configuration to investigate availability of CNT for electron microscopy. As a result, it is obtained that an emission area of MWNT is smaller than its tip surface area, and the emission area corresponds to a five-membered-ring with 2nd nearest six-membered-rings on the MWNT cap surface. Reduced brightness of MWNT is measured as at least 2.6×109 A/m 2 sr V. It is concluded that even a thick MWNT has enough brightness under a practical e-gun electrode configuration and suitable for electron microscopy.

  8. Emittance compensation of CW DC-gun photoinjector

    International Nuclear Information System (INIS)

    Li Peng; Wu Dai; Xu Zhou; Li Ming; Yang Xingfan

    2011-01-01

    Emittance growth induced by space charge effect is very important, especially for CW DC-gun photoinjector. In this work, the linear space charge force and its effect on electron beam transverse emittance are studied, and the principle and properties of emittance compensation by solenoid are analyzed. The CAEP DC-gun photoinjector with a solenoid is also simulated by code Parmela. Simulated results indicate that the normalized transverse emittance of an 80 pC bunch at the 350 keV DC-gun ex-it is 5.14 mm · mrad. And after compensated by a solenoid, it becomes 1.27 mm · mrad. The emittance of beam is well compensated. (authors)

  9. Internal Auger emitters: effects on spermatogenesis and oogenesis in mice

    International Nuclear Information System (INIS)

    Rao, D.V.; Mylavarapu, V.B.; Sastry, K.S.R.; Howell, R.W.

    1988-01-01

    The in vivo biological effects of Auger emitters are investigated using [A] spermatogenesis in mouse testis, and [B] oogenesis in mouse ovary as experimental models. Spermhead survival and induction of abnormal sperm, following intratesticular administration of radiopharmaceuticals, were the end points in Model A. Of interest in Model B is primary oocyte survival after intraperitoneal injection of the radiochemicals. The effectiveness of the Auger emitter is determined relative to its beta emitting companion or external X-rays in the absence of such an analogue. Results reveal pronounced effects of Auger emitters on all end points, not dependent on mode of administration. The efficacy of the Auger emitter is related intimately to its subcellular distribution, which, is governed by the chemical form of the carrier molecule. Conventional dosimetry is inadequate and biophysically meaningful dosimetric approaches are needed to understand in vivo effects of Auger emitters. (author)

  10. Nullspace MUSIC and Improved Radio Frequency Emitter Geolocation from a Mobile Antenna Array

    Science.gov (United States)

    Kintz, Andrew L.

    geolocates multiple simultaneous and co-frequency emitters in spite of highly erratic DOA estimates. We also mitigate manifold mismatch by applying the Direct Mapping Method (DMM). DMM averages DOA spectra on the earth(apostrophe)s surface and estimates the emitter locations directly from the composite spectrum. In the example results presented, our goal is to geolocate four diversely polarized emitters with a seven-element antenna array. This is too challenging for MAAE and DMM. We fuse Nullspace MUSIC and DMM into the novel Nullspace DMM algorithm and demonstrate that Nullspace DMM locates all emitters. Finally, we apply the proposed geolocation algorithms to real-world experimental data. A six-element antenna array and Data Collection System (DCS) were installed on a small aircraft. The DCS recorded signals from four live transmitters during a three-hour flight over Columbus, Ohio. The four emitters were geolocated from various segments of the flight. As expected, individual DOA estimates were erratic and widespread due to the airplane(apostrophe)s perturbations of the measured array manifold. MAAE and DMM locate at most three of the four emitters. On the other hand, Nullspace DMM yields unambiguous estimates for every emitter in every flight segment. The successful experimental trials show that Nullspace DMM could significantly enhance airborne emitter geolocation in missions such as RF spectrum enforcement, locating unknown transmitters for defense, and search and rescue operations.

  11. Plasma treatment for producing electron emitters

    Science.gov (United States)

    Coates, Don Mayo; Walter, Kevin Carl

    2001-01-01

    Plasma treatment for producing carbonaceous field emission electron emitters is disclosed. A plasma of ions is generated in a closed chamber and used to surround the exposed surface of a carbonaceous material. A voltage is applied to an electrode that is in contact with the carbonaceous material. This voltage has a negative potential relative to a second electrode in the chamber and serves to accelerate the ions toward the carbonaceous material and provide an ion energy sufficient to etch the exposed surface of the carbonaceous material but not sufficient to result in the implantation of the ions within the carbonaceous material. Preferably, the ions used are those of an inert gas or an inert gas with a small amount of added nitrogen.

  12. Gamma emitters in Hong Kong water

    International Nuclear Information System (INIS)

    Shun-Yin, L.; Chung-Keung, M.; Wai-Kwok, N.; Shiu-Chun, A.

    1990-01-01

    Radioactivity in water originates from natural and artificial sources. The development of a nuclear powerplant near Hong Kong necessitates that attention be given to formulating techniques to assess the possible resultant environmental radioactive contamination. Water samples collected from various sites in Hong Kong in the spring and summer of 1987, representing seawater, river water, reservoir water, drinking water, and underground water were studied through gamma-ray spectral analysis. Only gamma emitters in the U238 and Th232 series and K40 were detected. No fission product was detected with specific activity above 0.1 Bq/kg. The data could be the baseline for future monitoring of the radioactivity released from a nuclear plant being built at a 50-km distance from Hong Kong. The variation of detected specific activities may be due to geological differences and the effect of plants. 1 ref., 3 tabs

  13. Passivated emitters in silicon solar cells

    International Nuclear Information System (INIS)

    King, R.R.; Gruenbaum, P.E.; Sinton, R.A.; Swanson, R.M.

    1990-01-01

    In high-efficiency silicon solar cells with low metal contact coverage fractions and high bulk lifetimes, cell performance is often dominated by recombination in the oxide-passivated diffusions on the cell surface. Measurements of the emitter saturation current density, J o , of oxide-passivated, boron and phosphorus diffusions are presented, and from these measurements, the dependence of surface recombination velocity on dopant concentration was extracted. The lowest observed values of J o which are stable under UV light are given for both boron- and phosphorus-doped, oxide-passivated diffusions, for both textured and untextured surfaces. Contour plots which incorporate the above data have been applied to two types of backside-contact solar cells with large area (37.5 cm 2 ) and one-sun efficiencies up to 22.7%

  14. In ovo method for evaluating the effect of nutritional therapies on tumor development, growth and vascularization

    OpenAIRE

    Dupertuis, Yves M.; Delie, Florence; Cohen, Marie; Pichard, Claude

    2015-01-01

    In the state of the art evaluation of nutritional therapy on tumor development, growth and vascularization requires tedious and expensive in vivo assays in which a significant number of animals undergo invasive treatments. Therefore, new alternative methods to avoid animal suffering and sacrifice are welcome. This review presents a rapid and low-cost method of experimental radio/chemotherapy in tumor xenografted chicken chorioallantoic membrane (CAM), which may contribute to implement the 3R ...

  15. Physical therapy methods in the treatment and rehabilitation of cancer patients

    International Nuclear Information System (INIS)

    Kucherova, T. Ya.; Choinzonov, E. L.; Tuzikov, S. A.; Vusik, M. V.; Doroshenko, A. V.; Velikaya, V. V.; Gribova, O. V.; Startseva, Zh. A.

    2016-01-01

    The results of the effective use of magnetic laser therapy in the treatment and rehabilitation of cancer patients were presented. The effect of magnetic-laser therapy in the treatment of radiation-induced reactions in the patients with head and neck cancer and in the patients with breast cancer was analyzed. High efficiency of lymphedema and lymphorrhea treatment in the postoperative period in the patients with breast cancer was proved. The results of rehabilitation of the patients with gastric cancer after surgical treatment were presented. These data indicate a high effectiveness of different physical methods of treatment and rehabilitation of cancer patients.

  16. Sex and couples therapy: a method of treatment to enhance physical and emotional intimacy.

    Science.gov (United States)

    Russell, L

    1990-01-01

    It has been well documented that couples presenting for sex therapy frequently have difficulties in resolving conflict and in expressing emotional as well as physical intimacy. Recent studies have shown that intimacy is an important variable in determining the health or pathology in the dyadic system. Furthermore, the level of intimacy is influenced by a capacity for self disclosure and an ability to consider the partner's opinion. This paper describes a method of treatment that combines well-known strategies to treat sexual problems with a new approach to couples therapy, which encourages self-disclosure to facilitate mutual understanding, decrease conflict, and increase intimacy.

  17. Design and Development of Emittance Measurement Device by Using the Pepper-pot Technique

    Science.gov (United States)

    Pakluea, S.; Rimjaem, S.

    2017-09-01

    Transverse emittance of a charged particle beam is one of the most important properties that reveals the quality of the beam. It is related to charge density, transvers size and angular displacement of the beam in transverse phase space. There are several techniques to measure the transverse emittance value. One of practical methods is the pepper-pot technique, which can measure both horizontal and vertical emittance value in a single measurement. This research concentrates on development of a pepper-pot device to measure the transverse emittance of electron beam produced from an accelerator injector system, which consists of a thermionic cathode RF electron gun and an alpha magnet, at the Plasma and Beam Physics Research Facility, Chiang Mai University. Simulation of beam dynamics was conducted with programs PARMELA, ELEGANT and self-developed codes using C and MATLAB. The geometry, dimensions and location of the pepper-pot as well as its corresponding screen station position were included in the simulation. The result from this study will be used to design and develop a practical pepper-pot experimental station.

  18. High resolution structuring of emitter tips for the gaseous field ionization source

    International Nuclear Information System (INIS)

    Kubby, J.A.; Siegel, B.M.

    1986-01-01

    Extraction of a stable, high brightness ion beam from an apertured field ion emitter surface requires microfabrication procedures to sculpture the surface topography on both microscopic (100 --1000 nm) and near atomic (10 --100 nm) length scales. Structuring on a near atomic scale is required to confine and stabilize the ion beam by local enhancement of the surface electrostatic field and to orient that emission on the optical axis. Control of the emitter contour on a microscopic scale is required for manipulating the supply of neutral molecules to the ionization site and also affects beam stability. We have developed a method using ion milling for configuring surface contour on microscopic and near atomic length scales which utilizes the morphological changes occurring at ion bombarded surfaces as a result of erosion by sputtering. A SEM study of the microscopic emitter topographical development is compared to computer simulations of the kinematical wave equation which depicts the erosion process. In this way, prediction of configuration on a length scale large compared to the ion penetration depth has been established. TEM observations show the surface development on the length scale of ion penetration depth. Preliminary results using this microfabricated emitter in a gaseous field ion source to produce a hydrogen ion beam with high angular beam confinement are given. Requirements for surface topography that are essential to obtain stable high brightness ion beams are discussed

  19. Comparison between arc drops in ignited thermionic converters with and without ion reflections at the emitter

    International Nuclear Information System (INIS)

    Lundgren, L.

    1985-01-01

    The output performance of two thermionic energy converters is compared. One converter has a normal emitter, working with zero field at the emitter which is close to the optimum working point, and the other has a low work function emitter and ion reflection at the emitter. A simple model of the plasma and the sheaths shows that a converter working with a low work function emitter and ion reflections gives a worse performance than a similar converter with a normal emitter

  20. Cooperative spontaneous emission of nano-emitters with inter-emitter coupling in a leaky microcavity

    International Nuclear Information System (INIS)

    Hong, Suc-Kyoung; Nam, Seog Woo; Yang, Hyung Jin

    2015-01-01

    We study the spontaneous emission from a few two-level nano-emitters placed in a leaky microcavity with Lorentzian spectral density near a critically damped regime. Collective features of the spontaneous emission are investigated by numerical analysis of the excitation dynamics when initially one nano-emitter is totally excited but we do not know which one. The results show that there are three decay rates in the excitation dynamics, two for simple exponential decays and one for damped oscillatory decay. The excitation dynamics is found to critically depend on the regime of the system. It is shown that the spontaneous emission is enhanced or suppressed depending on whether the system is in the underdamped or overdamped regime, respectively. On the other hand, the cooperative spontaneous emission is suppressed in the underdamped while it is enhanced in the overdamped regime. Furthermore, the effect of the direct inter-emitter coupling on the breaking of the cooperativeness of the spontaneous emission is shown as well. (paper)

  1. [Physical treatment methods for acne. Light, laser, photodynamic therapy and peeling].

    Science.gov (United States)

    Borelli, C; Korting, H C

    2010-02-01

    The medical treatment of acne is generally sufficient to meet the expectations of acne patients. However, in a number of situations additional therapeutic approaches may be advisable. There are a wide variety of useful physical methods. They range from electromagnetic waves, usually light, to peeling and manual therapy. Phototherapy of acne includes not just visible light but also laser and flash lamp therapy. The present review provides an overview on the evidence. Visible light, in particular blue light, provides an effective option for treatment of inflammatory acne. Photodynamic therapy also is efficacious; however, it should not be used because of an unfavorable risk-benefit ratio. UV treatment of acne is obsolete. Newer studies on the use of a variety of laser systems and flash lamps have demonstrated in part rewarding results.

  2. [Attention diversion in tinnitus therapy. Comparison of the effects of different treatment methods].

    Science.gov (United States)

    Eysel-Gosepath, K; Gerhards, F; Schicketanz, K-H; Teichmann, K; Benthien, M

    2004-05-01

    Diversion or distraction of auditory attention is a core principle of tinnitus retraining therapy as introduced by P. Jastreboff and J. Hazell. The aim of this study was to evaluate the effectiveness of a different form of attention diversion in tinnitus therapy. In a prospective and randomized study, 40 patients suffering from chronic tinnitus were assigned to two different groups, A or B. All patients received appropriate counselling and were instructed in relaxation training. Patients in group A learned to distract attention away from the tinnitus by using sound or music. White noise generators or hearing aids were applied in this group. Patients in group B were instructed to direct their attention away from the tinnitus using imagination that was facilitated by the use of light and warmth stimuli as distracters. Different standardized questionnaires were used for an evaluation of therapy effectiveness. In both groups, patients were significantly less annoyed and disabled by their tinnitus immediately after therapy and after 6 months. Tinnitus annoyance still proved to be reduced 1 year after the end of the therapy. There were no significant differences in the effects of each treatment. Attention diversion is an important method for decreasing tinnitus-related distress. Patients should be instructed to use not only auditory but also visual and thermal sensations in order to distract attention away from their tinnitus.

  3. Determination of substraces of alpha emitter elements in water

    International Nuclear Information System (INIS)

    Gascon, J.L.

    1990-01-01

    To determine alpha emitter elements in water by alpha spectrometry, it is necessary to use large volumes of samples, concentration techniq-ues and to separate the elements of interest. In this report a study is presented about two concentration techniques and the process of analysis. Firstly, the stages of concentration method by iron hydroxide coprecipitation were studied in order to improve the results. The combination of liquid-liquid extraction and ion exchange techniques was the best way. Secondly, the technique by adsorption on manganese dioxide was studied. To apply this technique it was necessary to develop analysis methods to separate uranium, thorium, plutonium, americium and radium. These methods were designed combining several techniques of separation: liquid-liquid extraction, liquid-solid extraction, ionic exchange and coprecipitation. After the analysis methods were developped the adsorption on manganese dioxide with artificial samples was studied in the laboratory. Finally, the method of adsorption on manganese dioxide was studied to determine uranium, thorium and radium in the drinking water of Madrid. (Author)

  4. An Observation of a Transverse to Longitudinal Emittance Exchange at the Fermilab A0 Photoinjector

    Energy Technology Data Exchange (ETDEWEB)

    Koeth, Timothy W [State Univ. of New Jersey, New Brunswick, NJ (United States)

    2009-05-01

    An experimental program to perform a proof of principle of transverse to longitudinal emittance exchange (ϵxin ↔ ϵzout and ϵxin ↔ ϵzout) has been developed at the Fermilab A0 Photoinjector. A new beamline, including two magnetic dogleg channels and a TM110 deflecting mode radio frequency cavity, were constructed for the emittance exchange experiment. The first priority was a measurement of the Emittance Exchange beamline transport matrix. The method of difference orbits was used to measure the transport matrix. Through varying individual beam input vector elements, such as xin, x'in, yin, y'in, zin, or δin, and measuring the changes in all of the beam output vector's elements, xout, x'out, yout, y'out, zout, δout, the full 6 x 6 transport matrix was measured. The measured emittance exchange transport matrix was in overall good agreement with our calculated transport matrix. A direct observation of an emittance exchange was performed by measuring the electron beam's characteristics before and after the emittance exchange beamline. Operating with a 14.3 MeV, 250pC electron bunch, ϵzin of 21.1 ± 1.5 mm • mrad was observed to be exchanged with ϵxout of 20.8 ± 2.00 mm • mrad. Diagnostic limitations in the ϵzout measurement did not account for an energy-time correlation, thus potentially returning values larger than the actual longitudinal emittance. The ϵxin of 4.67 ± 0.22 mm • mrad was observed to be exchanged with ϵzout of 7.06 ± 0.43 mm • mrad. The apparent ϵzoutgrowth is consistent with calculated values in which the correlation term is neglected.

  5. Emittance variations in current-amplifying ion induction linacs

    International Nuclear Information System (INIS)

    Fessenden, T.J.

    1991-01-01

    Since 1985 the Heavy Ion Fusion Accelerator Research program at the Lawrence Berkeley Laboratory has been studying current amplification and emittance variations in MBE-4, a four-cesium-beam induction linac. This experiment models much of the accelerator physics of the electrostatically focused section of a fusion driver. Four space-charge dominated Cs + beams, initially about one meter in length at currents of 5-10 mA, are focused by electrostatic quadrupoles and accelerated in parallel from approximately 200 keV up to one MeV by 24 accelerating gaps. Final currents of 20-40 mA per beam are typical. Recent experiments with extremely low emittance beams (var-epsilon n =0.03 mm-mRad) have investigated variations of transverse and longitudinal normalized emittance for drifting and accelerating beams. These very strongly tune-depressed beams (σ 0 =72 degree, σ∼6 degree) are difficult to match to the accelerator so as to avoid emittance growth during acceleration. During transport strong emittance fluctuations are observed in good qualitative agreement with simulations. Warmer beams with less tune depression exhibit little to no emittance growth, show smaller emittance fluctuations, and are much easier to match. A summary of findings from the MBE-4 studies is presented

  6. Emittance variations in current-amplifying ion induction linacs

    International Nuclear Information System (INIS)

    Fessenden, T.J.

    1991-04-01

    Since 1985 the Heavy Ion Fusion Accelerator Research program at the Lawrence Berkeley Laboratory has been studying current amplification and emittance variations in MBE-4, a four-cesium-beam induction linac. This experiment models much of the accelerator physics of the electrostatically focused section of a fusion driver. Four space-charge dominated Cs + beams, initially about one meter in length at currents of 5--10 mA, are focused by electrostatic quadrupoles and accelerated in parallel from approximately 200 keV up to one MeV by 24 accelerating gaps. Final currents of 20--40 mA per beam are typical. Recent experiments with extremely low emittance beams (ε n = 0.03 mm-mRad) have investigated variations of transverse and longitudinal normalized emittance for drifting and accelerating beams. These very strongly tune-depressed beams (σ o = 72 degrees, σ∼6 degree) are difficult to match the accelerator so as to avoid emittance growth during acceleration. During transport strong emittance fluctuations are observed in good qualitative agreement with simulations. Warmer beams with less tune depression exhibit little to no emittance growth, show smaller emittance fluctuations, and are much easier to match. A summary of findings from the MBE-4 studies is presented. 12 refs., 8 figs

  7. Emittance and beam size distortion due to linear coupling

    International Nuclear Information System (INIS)

    Parzen, G.

    1993-01-01

    At injection, the presence of linear coupling may result in an increased beam emittance and in increased beam dimensions. Results for the emittance in the presence of linear coupling will be found. These results for the emittance distortion show that the harmonics of the skew quadrupole field close to ν x + ν y are the important harmonics. Results will be found for the important driving terms for the emittance distortion. It will be shown that if these driving terms are corrected, then the total emittance is unchanged, var-epsilon x + var-epsilon y = var-epsilon 1 + var-epsilon 2 . Also, the increase in the beam dimensions will be limited to a factor which is less than 1.414. If the correction is good enough, see below for details, one can achieve var-epsilon 1 = var-epsilon x , var-epsilon 2 = var-epsilon where var-epsilon 1 , var-epsilon 2 are the emittances in the presence of coupling, and the beam dimensions are unchanged. Global correction of the emittance and beam size distortion appears possible

  8. The use of human factors methods to identify and mitigate safety issues in radiation therapy

    International Nuclear Information System (INIS)

    Chan, Alvita J.; Islam, Mohammad K.; Rosewall, Tara; Jaffray, David A.; Easty, Anthony C.; Cafazzo, Joseph A.

    2010-01-01

    Background and purpose: New radiation therapy technologies can enhance the quality of treatment and reduce error. However, the treatment process has become more complex, and radiation dose is not always delivered as intended. Using human factors methods, a radiotherapy treatment delivery process was evaluated, and a redesign was undertaken to determine the effect on system safety. Material and methods: An ethnographic field study and workflow analysis was conducted to identify human factors issues of the treatment delivery process. To address specific issues, components of the user interface were redesigned through a user-centered approach. Sixteen radiation therapy students were then used to experimentally evaluate the redesigned system through a usability test to determine the effectiveness in mitigating use errors. Results: According to findings from the usability test, the redesigned system successfully reduced the error rates of two common errors (p < .04 and p < .01). It also improved the mean task completion time by 5.5% (p < .02) and achieved a higher level of user satisfaction. Conclusions: These findings demonstrated the importance and benefits of applying human factors methods in the design of radiation therapy systems. Many other opportunities still exist to improve patient safety in this area using human factors methods.

  9. Few emitters in a cavity: from cooperative emission to individualization

    International Nuclear Information System (INIS)

    Auffeves, A; Portolan, S; Gerace, D; Drezet, A; Franca Santos, M

    2011-01-01

    We study the temporal correlations of the field emitted by an electromagnetic resonator coupled to a mesoscopic number of two-level emitters that are incoherently pumped by a weak external drive. We solve the master equation of the system for increasing number of emitters and as a function of the cavity quality factor, and we identify three main regimes characterized by well-distinguished statistical properties of the emitted radiation. For small cavity decay rates, the emission events are uncorrelated and the number of photons in the emitted field becomes larger than one, resembling the build-up of a laser field inside the cavity. At intermediate decay rates (as compared with the emitter-cavity coupling) and for a few emitters, the statistics of the emitted radiation is bunched and strikingly dependent on the parity of the number of emitters. The latter property is related to the cooperativity of the emitters mediated by their coupling to the cavity mode, and its connection with steady-state subradiance is discussed. Finally, in the bad cavity regime the typical situation of emission from a collection of individual emitters is recovered. We also analyze how the cooperative behavior evolves as a function of pure dephasing, which allows us to recover the case of a classical source made of an ensemble of independent emitters, similar to what is obtained for a very leaky cavity. State-of-the-art techniques of Q-switch of resonant cavities, allied with the recent capability of tuning single emitters in and out of resonance, suggest this system to be a versatile source of different quantum states of light.

  10. Few emitters in a cavity: from cooperative emission to individualization

    Energy Technology Data Exchange (ETDEWEB)

    Auffeves, A; Portolan, S [CEA/CNRS/UJF Joint Team ' Nanophysics and Semiconductors' , Institut Neel-CNRS, BP 166, 25 Rue des Martyrs, 38042 Grenoble Cedex 9 (France); Gerace, D [Dipartimento di Fisica ' Alessandro Volta' and UdR CNISM, Universita di Pavia, via Bassi 6, 27100 Pavia (Italy); Drezet, A [Institut Neel-CNRS, BP 166, 25 Rue des Martyrs, 38042 Grenoble Cedex 9 (France); Franca Santos, M, E-mail: msantos@fisica.ufmg.br [Departamento de Fisica, Universidade Federal de Minas Gerais, Belo Horizonte, CP 702, 30123-970 (Brazil)

    2011-09-15

    We study the temporal correlations of the field emitted by an electromagnetic resonator coupled to a mesoscopic number of two-level emitters that are incoherently pumped by a weak external drive. We solve the master equation of the system for increasing number of emitters and as a function of the cavity quality factor, and we identify three main regimes characterized by well-distinguished statistical properties of the emitted radiation. For small cavity decay rates, the emission events are uncorrelated and the number of photons in the emitted field becomes larger than one, resembling the build-up of a laser field inside the cavity. At intermediate decay rates (as compared with the emitter-cavity coupling) and for a few emitters, the statistics of the emitted radiation is bunched and strikingly dependent on the parity of the number of emitters. The latter property is related to the cooperativity of the emitters mediated by their coupling to the cavity mode, and its connection with steady-state subradiance is discussed. Finally, in the bad cavity regime the typical situation of emission from a collection of individual emitters is recovered. We also analyze how the cooperative behavior evolves as a function of pure dephasing, which allows us to recover the case of a classical source made of an ensemble of independent emitters, similar to what is obtained for a very leaky cavity. State-of-the-art techniques of Q-switch of resonant cavities, allied with the recent capability of tuning single emitters in and out of resonance, suggest this system to be a versatile source of different quantum states of light.

  11. Paradigms, pragmatism and possibilities: mixed-methods research in speech and language therapy.

    Science.gov (United States)

    Glogowska, Margaret

    2011-01-01

    After the decades of the so-called 'paradigm wars' in social science research methodology and the controversy about the relative place and value of quantitative and qualitative research methodologies, 'paradigm peace' appears to have now been declared. This has come about as many researchers have begun to take a 'pragmatic' approach in the selection of research methodology, choosing the methodology best suited to answering the research question rather than conforming to a methodological orthodoxy. With the differences in the philosophical underpinnings of the two traditions set to one side, an increasing awareness, and valuing, of the 'mixed-methods' approach to research is now present in the fields of social, educational and health research. To explore what is meant by mixed-methods research and the ways in which quantitative and qualitative methodologies and methods can be combined and integrated, particularly in the broad field of health services research and the narrower one of speech and language therapy. The paper discusses the ways in which methodological approaches have already been combined and integrated in health services research and speech and language therapy, highlighting the suitability of mixed-methods research for answering the typically multifaceted questions arising from the provision of complex interventions. The challenges of combining and integrating quantitative and qualitative methods and the barriers to the adoption of mixed-methods approaches are also considered. The questions about healthcare, as it is being provided in the 21st century, calls for a range of methodological approaches. This is particularly the case for human communication and its disorders, where mixed-methods research offers a wealth of possibilities. In turn, speech and language therapy research should be able to contribute substantively to the future development of mixed-methods research. © 2010 Royal College of Speech & Language Therapists.

  12. [Predictive methods versus clinical titration for the initiation of lithium therapy. A systematic review].

    Science.gov (United States)

    Geeraerts, I; Sienaert, P

    2013-01-01

    When lithium is administered, the clinician needs to know when the lithium in the patient’s blood has reached a therapeutic level. At the initiation of treatment the level is usually achieved gradually through the application of the titration method. In order to increase the efficacy of this procedure several methods for dosing lithium and for predicting lithium levels have been developed. To conduct a systematic review of the publications relating to the various methods for dosing lithium or predicting lithium levels at the initiation of therapy. We searched Medline systematically for articles published in English, French or Dutch between 1966 and April 2012 which described or studied a method for dosing lithium or for predicting the lithium level reached following a specific dosage. We screened the reference lists of relevant articles in order to locate additional papers. We found 38 lithium prediction methods, in addition to the clinical titration method. These methods can be divided into two categories: the ‘a priori’ methods and the ‘test-dose’ methods, the latter requiring the administration of a test dose of lithium. The lithium prediction methods generally achieve a therapeutic blood level faster than the clinical titration method, but none of the methods achieves convincing results. On the basis of our review, we propose that the titration method should be used as the standard method in clinical practice.

  13. Design of a minimum emittance nBA lattice

    Science.gov (United States)

    Lee, S. Y.

    1998-04-01

    An attempt to design a minimum emittance n-bend achromat (nBA) lattice has been made. One distinct feature is that dipoles with two different lengths were used. As a multiple bend achromat, five bend achromat lattices with six superperiod were designed. The obtained emittace is three times larger than the theoretical minimum. Tunes were chosen to avoid third order resonances. In order to correct first and second order chromaticities, eight family sextupoles were placed. The obtained emittance of five bend achromat lattices is almost equal to the minimum emittance of five bend achromat lattice consisting of dipoles with equal length.

  14. Multi-dimensional beam emittance and β-functions

    International Nuclear Information System (INIS)

    Buon, J.

    1993-05-01

    The concept of r.m.s. emittance is extended to the case of several degrees of freedom that are coupled. That multi-dimensional emittance is lower than the product of the emittances attached to each degree of freedom, but is conserved in a linear motion. An envelope-hyperellipsoid is introduced to define the β-functions of the beam envelope. On the contrary of an one-degree of freedom motion, it is emphasized that these envelope functions differ from the amplitude functions of the normal modes of motion as a result of the difference between the Liouville and Lagrange invariants. (author) 4 refs

  15. Engineered Emitters for Improved Silicon Photovoltaics

    Science.gov (United States)

    Kamat, Ronak A.

    In 2014, installation of 5.3GW of new Photovoltaic (PV) systems occurred in the United States, raising the total installed capacity to 16.36GW. Strong growth is predicted for the domestic PV market with analysts reporting goals of 696GW by 2020. Conventional single crystalline silicon cells are the technology of choice, accounting for 90% of the installations in the global commercial market. Cells made of GaAs offer higher efficiencies, but at a substantially higher cost. Thin film technologies such as CIGS and CdTe compete favorably with multi-crystalline Si (u-Si), but at 20% efficiency, still lag the c-Si cell in performance. The c-Si cell can be fabricated to operate at approximately 25% efficiency, but commercially the efficiencies are in the 18-21% range, which is a direct result of cost trade-offs between process complexity and rapid throughput. With the current cost of c-Si cell modules at nearly 0.60/W. The technology is well below the historic metric of 1/W for economic viability. The result is that more complex processes, once cost-prohibitive, may now be viable. An example is Panasonic's HIT cell which operates in the 22-24% efficiency range. To facilitate research and development of novel PV materials and techniques, RIT has developed a basic solar cell fabrication process. Student projects prior to this work had produced cells with 12.8% efficiency using p type substrates. This thesis reports on recent work to improve cell efficiencies while simultaneously expanding the capability of the rapid prototyping process. In addition to the p-Si substrates, cells have been produced using n-Si substrates. The cell emitter, which is often done with a single diffusion or implant has been re-engineered using a dual implant of the same dose. This dual-implanted emitter has been shown to lower contact resistance, increase Voc, and increase the efficiency. A p-Si substrate cell has been fabricated with an efficiency of 14.6% and n-Si substrate cell with a 13

  16. Improved Rare-Earth Emitter Hollow Cathode

    Science.gov (United States)

    Goebel, Dan M.

    2011-01-01

    An improvement has been made to the design of the hollow cathode geometry that was created for the rare-earth electron emitter described in Compact Rare Earth Emitter Hollow Cathode (NPO-44923), NASA Tech Briefs, Vol. 34, No. 3 (March 2010), p. 52. The original interior assembly was made entirely of graphite in order to be compatible with the LaB6 material, which cannot be touched by metals during operation due to boron diffusion causing embrittlement issues in high-temperature refractory materials. Also, the graphite tube was difficult to machine and was subject to vibration-induced fracturing. This innovation replaces the graphite tube with one made out of refractory metal that is relatively easy to manufacture. The cathode support tube is made of molybdenum or molybdenum-rhenium. This material is easily gun-bored to near the tolerances required, and finish machined with steps at each end that capture the orifice plate and the mounting flange. This provides the manufacturability and robustness needed for flight applications, and eliminates the need for expensive e-beam welding used in prior cathodes. The LaB6 insert is protected from direct contact with the refractory metal tube by thin, graphite sleeves in a cup-arrangement around the ends of the insert. The sleeves, insert, and orifice plate are held in place by a ceramic spacer and tungsten spring inserted inside the tube. To heat the cathode, an insulating tube is slipped around the refractory metal hollow tube, which can be made of high-temperature materials like boron nitride or aluminum nitride. A screw-shaped slot, or series of slots, is machined in the outside of the ceramic tube to constrain a refractory metal wire wound inside the slot that is used as the heater. The screw slot can hold a single heater wire that is then connected to the front of the cathode tube by tack-welding to complete the electrical circuit, or it can be a double slot that takes a bifilar wound heater with both leads coming out

  17. Coincidence summing corrections for positron emitters in germanium gamma spectrometry

    International Nuclear Information System (INIS)

    Richardson, A.E.; Sallee, W.W.; New Mexico State Univ., Las Cruces

    1990-01-01

    For positron emitters, 511 keV annihilation quanta are in coincidence with other gamma rays in the decay scheme. If the positrons are not localized at the point of decay, annihilation quanta will be produced at a site some distance from the point of emission. The magnitude of the summing coincidence effect will depend upon the position of annihilation. A method for determining the magnitude of the summing effect for a single gamma of energy E in coincidence with the annihilation gammas from non-localized positrons has been developed which makes use of the counting data for the full energy peaks for both the gamma ray (E) and the 511 keV annihilation gammas. With this data and efficiency calibration data one can determine the average total efficiency for the annihilation positions from which 511 keV gammas originate, and thereby obtain the summing correction factor, SCF, for gamma ray (E). Application of the method to a 22 Na NIST standard gave excellent agreement of observed emission rates for the 1275 keV gamma with the NIST value for wide ranging degrees of positron localization having summing correction factors ranging from 1.021 to 1.505. The method was also applied successfully to 58 Co in neutron-irradiated nickel foils. The method shows promise as a check on the accuracy of the efficiency calibration for a particular detector geometry at the 511 keV energy and energies for other gammas associated with positron emission. (orig.)

  18. Plasmon-Assisted Selective and Super-Resolving Excitation of Individual Quantum Emitters on a Metal Nanowire.

    Science.gov (United States)

    Li, Qiang; Pan, Deng; Wei, Hong; Xu, Hongxing

    2018-03-14

    Hybrid systems composed of multiple quantum emitters coupled with plasmonic waveguides are promising building blocks for future integrated quantum nanophotonic circuits. The techniques that can super-resolve and selectively excite contiguous quantum emitters in a diffraction-limited area are of great importance for studying the plasmon-mediated interaction between quantum emitters and manipulating the single plasmon generation and propagation in plasmonic circuits. Here we show that multiple quantum dots coupled with a silver nanowire can be controllably excited by tuning the interference field of surface plasmons on the nanowire. Because of the period of the interference pattern is much smaller than the diffraction limit, we demonstrate the selective excitation of two quantum dots separated by a distance as short as 100 nm. We also numerically demonstrate a new kind of super-resolution imaging method that combines the tunable surface plasmon interference pattern on the NW with the structured illumination microscopy technique. Our work provides a novel high-resolution optical excitation and imaging method for the coupled systems of multiple quantum emitters and plasmonic waveguides, which adds a new tool for studying and manipulating single quantum emitters and single plasmons for quantum plasmonic circuitry applications.

  19. Dynamics of psychological crisis experience with psychological consulting by gestalt therapy methods.

    Science.gov (United States)

    Fahrutdinova, Liliya Raifovna; Nugmanova, Dzhamilia Renatovna

    2015-01-01

    Dynamics of experience as such and its corporeal, emotional and cognitive elements in the situation of psychological consulting provisioning is covered. The aim of research was to study psychological crisis experience dynamics in the situation when psychological consulting by gestalt therapy methods is provided. Theoretical analysis of the problem of crisis situations, phenomenon and structural, and dynamic organization of experience of the subject of consulting have been carried out. To fulfill research project test subjects experience crisis situation have been selected, studied in the situation when they provided psychological consulting by methods of gestalt therapy, and methodology of study of crisis situations experience has been prepared. Specifics of psychological crisis experience have been revealed and its elements in different stages of psychological consulting by gestalt therapy methods. Dynamics of experience of psychological crisis and its structural elements have been revealed and reliable changes in it have been revealed. Dynamics of psychological crisis experience and its structural elements have been revealed and reliable changes in it have been revealed. "Desiccation" of experience is being observed, releasing its substantiality of negative impression to the end of consulting and development of the new experience of control over crisis situation. Interrelations of structural elements of experience in the process of psychological consulting have been shown. Effecting one structure causes reliable changes in all others structural elements of experience. Giving actual psychological help to clients in crisis situation by methods of gestalt therapy is possible as it was shown in psychological consulting sessions. Structure of client's request has been revealed - problems of personal sense are fixed as the most frequent cause of clients' applications, as well as absence of choices, obtrusiveness of negative thoughts, tend to getting stuck on events

  20. METHODS OF ASSESSMENT OF THE RELATIVE BIOLOGICAL EFFECTIVENESS OF NEUTRONS IN NEUTRON THERAPY

    Directory of Open Access Journals (Sweden)

    V. A. Lisin

    2017-01-01

    Full Text Available The relative biological effectiveness (RBE of fast neutrons is an important factor influencing the quality of neutron therapy therefore, the assessment of RBE is of great importance. Experimental and clinical studies as well as different mathematical and radiobiological models are used for assessing RBE. Research is conducted for neutron sources differing in the method of producing particles, energy and energy spectrum. Purpose: to find and analyze the dose-dependence of fast neutron RBE in neutron therapy using the U-120 cyclotron and NG-12I generator. Material and methods: The optimal method for assessing the relative biological effectiveness of neutrons for neutron therapy was described. To analyze the dependence of the RBE on neutron dose, the multi-target model of cell survival was applied. Results: The dependence of the RBE of neutrons produced from the U-120 cyclotron and NG-120 generator on the dose level was found for a single irradiation of biological objects. It was shown that the function of neutron dose was consistent with similar dependencies found by other authors in the experimental and clinical studies.

  1. Analysis of low energy beta-emitters

    International Nuclear Information System (INIS)

    Murphy, D.L.

    1979-10-01

    A survey was made of the instruments used for the determination of low energy beta radioactivity. Techniques commonly used are gas flow proportional counting, liquid scintillation counting, solid scintillation counting, and internal ionization chamber counting, solid state detector counting, and radiochemical separation followed by counting using one of the preceeding techniques. The first four techniques were examined and compared with each other. The sensitivities of the techniques were compared on the basis of the detection limits quoted for instruments described in the technical and reviewed literature. The detection limits were then related to the occupational and public individual maximum levels for air and water. Attention is focused primarily on the continuous monitoring of air for 3 H and 85 Kr, a medium energy β-emitter. It is clear that several continuous air monitoring instruments are readily available for measuring low energy β concentrations, even in presence of certain other activity, at occupational levels. However, these instruments do not typically have sensitivities comparable to the public individual levels. Moreover, their capabilities for giving results in real time and for differentiating among the radionuclides actually present is limited

  2. Sources of Emittance in RF Photocathode Injectors

    Energy Technology Data Exchange (ETDEWEB)

    Dowell, David [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2016-12-11

    Advances in electron beam technology have been central to creating the current generation of x-ray free electron lasers and ultra-fast electron microscopes. These once exotic devices have become essential tools for basic research and applied science. One important beam technology for both is the electron source which, for many of these instruments, is the photocathode RF gun. The invention of the photocathode gun and the concepts of emittance compensation and beam matching in the presence of space charge and RF forces have made these high-quality beams possible. Achieving even brighter beams requires a taking a finer resolution view of the electron dynamics near the cathode during photoemission and the initial acceleration of the beam. In addition, the high brightness beam is more sensitive to degradation by the optical aberrations of the gun’s RF and magnetic lenses. This paper discusses these topics including the beam properties due to fundamental photoemission physics, space charge effects close to the cathode, and optical distortions introduced by the RF and solenoid fields. Analytic relations for these phenomena are derived and compared with numerical simulations.

  3. A numerical study of emittance growths in RF guns

    CERN Document Server

    Masuda, K; Sobajima, M; Kitagaki, J; Ohnishi, M; Toku, H; Yoshikawa, K

    1999-01-01

    A beam with greatly reduced emittance is required for further improvements of FELs, in particular, for FELs of shorter wavelengths, and of narrower bandwidths. From this viewpoint, the BNL/SLAC/UCLA 1.6-cell S-band photocathode RF gun performance characteristics were calculated, first in order to evaluate what may contribute to the emittance growths in photocathode RF guns. We developed an RF gun to produce an electron beam with an extremely low emittance, by using a 2-D simulation code. It is found that, by optimizing the laser injection phase, the drive laser spot radius and the cavity shape around the laser spot, the beam emittance by the 1.6-cell RF gun can be greatly reduced to 2.1 pi mm mrad, from the previous 4.4 pi mm mrad of the original shape.

  4. An Online Multisensor Data Fusion Framework for Radar Emitter Classification

    Directory of Open Access Journals (Sweden)

    Dongqing Zhou

    2016-01-01

    Full Text Available Radar emitter classification is a special application of data clustering for classifying unknown radar emitters in airborne electronic support system. In this paper, a novel online multisensor data fusion framework is proposed for radar emitter classification under the background of network centric warfare. The framework is composed of local processing and multisensor fusion processing, from which the rough and precise classification results are obtained, respectively. What is more, the proposed algorithm does not need prior knowledge and training process; it can dynamically update the number of the clusters and the cluster centers when new pulses arrive. At last, the experimental results show that the proposed framework is an efficacious way to solve radar emitter classification problem in networked warfare.

  5. Emittance measuring unit for 100% duty factor linac injector beams

    Energy Technology Data Exchange (ETDEWEB)

    Shubaly, M R; Pachner, J Jr; Ormrod, J H; Ungrin, J; Schriber, S O [ed.

    1976-11-01

    A description is given of a system to measure the emittance of a 750 keV 100 mA dc proton beam suitable for injection into a 100% duty factor linear accelerator. A relatively slowly pulsed 45/sup 0/ magnet switches the beam to a beam dump inside the emittance measuring unit for approx. 10 s. A fast pulsed 5/sup 0/ magnet then deflects the beam to a multiple aperture ''pepper-pot'' plate for 300 ..mu..s. Beamlets passing through the plate travel 520 mm and produce a pattern on a scintillator screen. A photograph of the pattern is analyzed to determine beam emittance. Preliminary results on low current beams show a gross increase in the emittance in the horizontal plane.

  6. Localization of Narrowband Single Photon Emitters in Nanodiamonds.

    Science.gov (United States)

    Bray, Kerem; Sandstrom, Russell; Elbadawi, Christopher; Fischer, Martin; Schreck, Matthias; Shimoni, Olga; Lobo, Charlene; Toth, Milos; Aharonovich, Igor

    2016-03-23

    Diamond nanocrystals that host room temperature narrowband single photon emitters are highly sought after for applications in nanophotonics and bioimaging. However, current understanding of the origin of these emitters is extremely limited. In this work, we demonstrate that the narrowband emitters are point defects localized at extended morphological defects in individual nanodiamonds. In particular, we show that nanocrystals with defects such as twin boundaries and secondary nucleation sites exhibit narrowband emission that is absent from pristine individual nanocrystals grown under the same conditions. Critically, we prove that the narrowband emission lines vanish when extended defects are removed deterministically using highly localized electron beam induced etching. Our results enhance the current understanding of single photon emitters in diamond and are directly relevant to fabrication of novel quantum optics devices and sensors.

  7. Innovative energy efficient low-voltage electron beam emitters

    International Nuclear Information System (INIS)

    Felis, Kenneth P.; Avnery, Tovi; Berejka, Anthony J.

    2002-01-01

    Advanced electron beams (AEB) has developed a modular, low voltage (80-125 keV), high beam current (up to 40 ma), electron emitter with typically 25 cm of beam width, that is housed in an evacuated, returnable chamber that is easy to plug in and connect. The latest in nanofabrication enables AEB to use an ultra-thin beam window. The power supply for AEB's emitter is based on solid-state electronics. This combination of features results in a remarkable electrical efficiency. AEB's electron emitter relies on a touch screen, computer control system. With 80 μm of unit density beam penetration, AEB's electron emitter has gained market acceptance in the curing of opaque, pigmented inks and coatings used on flexible substrates, metals and fiber composites and in the curing of adhesives in foil based laminates

  8. Innovative energy efficient low-voltage electron beam emitters

    Science.gov (United States)

    Felis, Kenneth P.; Avnery, Tovi; Berejka, Anthony J.

    2002-03-01

    Advanced electron beams (AEB) has developed a modular, low voltage (80-125 keV), high beam current (up to 40 ma), electron emitter with typically 25 cm of beam width, that is housed in an evacuated, returnable chamber that is easy to plug in and connect. The latest in nanofabrication enables AEB to use an ultra-thin beam window. The power supply for AEB's emitter is based on solid-state electronics. This combination of features results in a remarkable electrical efficiency. AEB's electron emitter relies on a touch screen, computer control system. With 80 μm of unit density beam penetration, AEB's electron emitter has gained market acceptance in the curing of opaque, pigmented inks and coatings used on flexible substrates, metals and fiber composites and in the curing of adhesives in foil based laminates.

  9. Emittance measurements in low energy ion storage rings

    Science.gov (United States)

    Hunt, J. R.; Carli, C.; Resta-López, J.; Welsch, C. P.

    2018-07-01

    The development of the next generation of ultra-low energy antiproton and ion facilities requires precise information about the beam emittance to guarantee optimum performance. In the Extra-Low ENergy Antiproton storage ring (ELENA) the transverse emittances will be measured by scraping. However, this diagnostic measurement faces several challenges: non-zero dispersion, non-Gaussian beam distributions due to effects of the electron cooler and various systematic errors such as closed orbit offsets and inaccurate rms momentum spread estimation. In addition, diffusion processes, such as intra-beam scattering might lead to emittance overestimates. Here, we present algorithms to efficiently address the emittance reconstruction in presence of the above effects, and present simulation results for the case of ELENA.

  10. Very bright, near-infrared single photon emitters in diamond

    Directory of Open Access Journals (Sweden)

    D. W. M. Lau

    2013-09-01

    Full Text Available We demonstrate activation of bright diamond single photon emitters in the near infrared range by thermal annealing alone, i.e., without ion implantation. The activation is crucially dependent on the annealing ambient. The activation of the single photon emitters is only observed when the sample is annealed in forming gas (4% H2 in Ar above temperatures of 1000 °C. By contrast, no emitters are activated by annealing in vacuum, oxygen, argon or deuterium. The emitters activated by annealing in forming gas exhibit very bright emission in the 730-760 nm wavelength range and have linewidths of ∼1.5-2.5 nm at room temperature.

  11. Transverse emittance measurement at REGAE via a solenoid scan

    Energy Technology Data Exchange (ETDEWEB)

    Hachmann, Max

    2012-12-15

    The linear accelerator REGAE at DESY produces short and low charged electron bunches, on the one hand to resolve the excitation transitions of atoms temporally by pump probe electron diffraction experiments and on the other hand to investigate principal mechanisms of laser plasma acceleration. For both cases a high quality electron beam is required. A quantity to rate the beam quality is the beam emittance. In the course of this thesis transverse emittance measurements by a solenoid scan could be realized and beyond that an improved theoretical description of a solenoid was successful. The foundation of emittance measurements are constituted by theoretical models which describe the envelope of a beam. Two different models were derived. The first is an often used model to determine the transverse beam emittance without considering space charge effects. More interesting and challenging was the development of an envelope model taking space charge effects into account. It is introduced and cross checked with measurements and simulations.

  12. Design for a practical, low-emittance damping ring

    International Nuclear Information System (INIS)

    Krejcik, P.

    1988-01-01

    The luminosity requirements for future high-energy linear colliders calls for very low emittances in the two beams. These low emittances can be achieved with damping rings, but, in order to reach the design goal of a factor 10 improvement over present day machines, great care must be taken in their design. This paper emphasizes the need to address simultaneously all of the factors which limit the operational emittance in the ring. Particularly since in standard designs there is a conflict between different design parameters which makes it difficult to extrapolate such designs to very low emittances. The approach chosen here is to resolve such conflicts by separating their design solutions. Wigglers are used predominantly in zero-dispersion regions to achieve the desired damping rate, whereas in the arcs high dispersion insertions are made in regions of zero curvature to allow for easier chromaticity control

  13. Emittance increase caused by core depletion in collisions

    CERN Document Server

    Bruce, R

    2009-01-01

    A new effect is presented, which changes the emittance during colliding-beam operation in circular colliders. If the initial transverse distribution is Gaussian, the collision probability is much higher for particles in the core of the beam than in the tails. When small-amplitude particles are removed, the remaining ones therefore have a larger transverse emittance. This effect, called core depletion, may cause a decrease in luminosity. An approximate analytic model is developed to study the effect and benchmarked against a multiparticle tracking simulation. Finally, the time evolution of the intensity and emittances of a Pb bunch in the Large Hadron Collider (LHC) at CERN is calculated, taking into account also other processes than collisions. The results show that integrated luminosity drops by 3--4% if core depletion is taken into account. It is also found that core depletion causes the transverse emittance to be larger when more experiments are active. This observation could be checked against experimenta...

  14. Simulation studies of emittance growth in RMS mismatched beams

    International Nuclear Information System (INIS)

    Cucchetti, A.; Wangler, T.; Reiser, M.

    1991-01-01

    As shown in a separate paper, a charged-particle beam, whose rms size is not matched when injected into a transport channel or accelerator, has excess energy compared with that of a matched beam. If nonlinear space-charge forces are present and the mismatched beam transforms to a matched equilibrium state, rms-emittance growth will occur. The theory yields formulas for the possible rms-emittance growth, but not for the time it takes to achieve this growth. In this paper we present the results of systematic simulation studies for a mismatched 2-D round beam in an ideal transport channel with continuous linear focusing. Emittance growth rates obtained from the simulations for different amounts of mismatch and initial charge will be presented and the emittance growth will be compared with the theory. 6 refs., 7 figs

  15. CSR-induced emittance growth in achromats: Linear formalism revisited

    Energy Technology Data Exchange (ETDEWEB)

    Venturini, M.

    2015-09-11

    We review the R-matrix formalism used to describe Coherent Synchrotron Radiation (CSR)-induced projected emittance growth in electron beam transport lines and establish the connection with a description in terms of the dispersion-invariant function.

  16. Comparative evaluation of skin cancer therapy with impulse laser radiation and surgical methods

    International Nuclear Information System (INIS)

    Moskalik, K.G.; Kozlov, A.P.

    1980-01-01

    Altogether 324 patients with skin basilomas, 559 with recurrent basiloma and 38 with squamous-cell carcinoma of the skin were treated by means of impulse neodymium laser radiation. A follow-up period was up to 7 years. It was shown that impulse laser radiation is a highly effective means of treating skin cancer, having a number of advantages over the radiation and surgical methods. Laser radiation is also highly effective in the treatment of basiloma relapses. If relapses accounted for by the development of a radioresistant tumour occur at the sites where surgical eXcision yields an unstatisfactory cosmetic effect, laser therapy should be considered a method of choice

  17. Progress on low emittance tuning for the CLIC Damping Rings

    CERN Document Server

    Alabau-Gonzalvo, J; Papaphilippou, Y

    2014-01-01

    In the frame of the CLIC main Damping Ring a study on the sensitivity of the lattice to different sources of misalignment is presented. The minimum equilibrium emittance is simulated and analytically estimated under dipole and quadrupole rolls, and quadrupole and sextupole vertical offsets. The result of this study establishes alignment tolerances to preserve the vertical emittance below the design value (1 pmrad). Non-linear dynamics studies have been done to determine the dynamic aperture in the presence of misalignments.

  18. Emittance growth from rotated quadrupoles in heavy ion accelerators

    International Nuclear Information System (INIS)

    Barnard, J.J.

    1995-01-01

    We derive a set of moment equations which incorporates linear quadrupolar focusing and space-charge defocusing, in the presence of rotational misalignments of the quadrupoles about the direction of beam propagation. Although the usual beam emittance measured relative to fixed transverse x and y coordinate axes is not constant, a conserved emittance-like quantity has been found. Implications for alignment tolerances in accelerators for heavy-ion inertial fusion are discussed

  19. Minimum emittance of isochronus rings for synchrotron light source

    CERN Document Server

    Shoji, Y

    1999-01-01

    Theoretically achievable minimum emittances of isochronus rings for synchrotron light source are calculated. The rings discussed in this paper consist of isochronus and achromatic bending cells, isochronus TBA (triple bend achromat) cells with negative dispersion, isochronus TBA cells with inverse bends or isochronus QBA (four bend achromat) cells. We show that the minimum emittances of these rings are roughly 2 or 3 times of those of the optimized non-isochronus rings.

  20. Quantum emitters coupled to surface plasmons of an nanowire

    DEFF Research Database (Denmark)

    Dzsotjan, David; Sørensen, Anders Søndberg; Fleischhauer, Michael

    2010-01-01

    We investigate a system consisting of a single, as well as two emitters strongly coupled to surface plasmon modes of a nanowire using a Green's function approach. Explicit expressions are derived for the spontaneous decay rate into the plasmon modes and for the atom-plasmon coupling as well......-qubit quantum gate. We also discuss a possible realization of interesting many-body Hamiltonians, such as the spin-boson model, using strong emitter-plasmon coupling. Udgivelsesdato: 27 August...

  1. Internal emitter limits for iodine, radium and radon daughters

    Energy Technology Data Exchange (ETDEWEB)

    Schlenker, R.A.

    1984-08-15

    This paper identifies some of the issues which arise in the consideration of the derivation of new limits on exposure to internal emitters. Basic and secondary radiation protection limits are discussed. Terms are defined and applied to the limitation of risk from stochastic effects. Non-stochastic data for specific internal emitters (/sup 131/I and the radium isotopes) are presented. Emphasis is placed on the quantitative aspects of the limit setting problem. 65 references, 2 figures, 12 tables.

  2. Internal emitter limits for iodine, radium and radon daughters

    International Nuclear Information System (INIS)

    Schlenker, R.A.

    1984-01-01

    This paper identifies some of the issues which arise in the consideration of the derivation of new limits on exposure to internal emitters. Basic and secondary radiation protection limits are discussed. Terms are defined and applied to the limitation of risk from stochastic effects. Non-stochastic data for specific internal emitters ( 131 I and the radium isotopes) are presented. Emphasis is placed on the quantitative aspects of the limit setting problem. 65 references, 2 figures, 12 tables

  3. A Program to Generate a Particle Distribution from Emittance Measurements

    CERN Document Server

    Bouma, DS; Lallement, JB

    2010-01-01

    We have written a program to generate a particle distribution based on emittance measurements in x-x’ and y-y’. The accuracy of this program has been tested using real and constructed emittance measurements. Based on these tests, the distribution generated by the program can be used to accurately simulate the beam in multi-particle tracking codes, as an alternative to a Gaussian or uniform distribution.

  4. Beam emittance growth caused by transverse deflecting fields in a linear accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Chao, A W; Richter, B; Yao, C Y [Stanford Linear Accelerator Center, CA (USA)

    1980-12-01

    The effect of the beam-generated transverse deflecting fields on the emittance of an intense bunch of particles in a high-energy linear accelerator is analyzed in this paper. The equation of motion is solved by a perturbation method for cases of a coasting beam and a uniformly accelerated beam. The results are applied to obtain some design tolerance specifications for the recently proposed SLAC Single Pass Collider.

  5. High quality GaAs single photon emitters on Si substrate

    International Nuclear Information System (INIS)

    Bietti, S.; Sanguinetti, S.; Cavigli, L.; Accanto, N.; Vinattieri, A.; Minari, S.; Abbarchi, M.; Isella, G.; Frigeri, C.; Gurioli, M.

    2013-01-01

    We describe a method for the direct epitaxial growth of a single photon emitter, based on GaAs quantum dots fabricated by droplet epitaxy, working at liquid nitrogen temperatures on Si substrates. The achievement of quantum photon statistics up to T=80 K is directly proved by antibunching in the second order correlation function as measured with a H anbury Brown and Twiss interferometer

  6. Direct experimental observation of nonclassicality in ensembles of single-photon emitters

    Science.gov (United States)

    Moreva, E.; Traina, P.; Forneris, J.; Degiovanni, I. P.; Ditalia Tchernij, S.; Picollo, F.; Brida, G.; Olivero, P.; Genovese, M.

    2017-11-01

    In this work we experimentally demonstrate a recently proposed criterion addressed to detect nonclassical behavior in the fluorescence emission of ensembles of single-photon emitters. In particular, we apply the method to study clusters of nitrogen-vacancy centers in diamond characterized with single-photon-sensitive confocal microscopy. Theoretical considerations on the behavior of the parameter at any arbitrary order in the presence of Poissonian noise are presented and, finally, the opportunity of detecting manifold coincidences is discussed.

  7. Alpha spectrometry of thick sources. I. Application to alpha emitters determination

    International Nuclear Information System (INIS)

    Acena, M.L.; Garcia-Torano, E.; Rivero, M.C.

    1977-01-01

    A method for determining alpha emitters by silicon surface barrier detector spectroscopy using thick sources is studied. Two types of spectra have been obtained. They have different shapes of line according to the procedure used for preparing the sources. For both spectra a computing least square programme has been developed. In this way it is possible to calculate line intensities with accuracy better than 20 percent. (author) [es

  8. Gamma flux responsive self-powered detector with a tubular emitter

    International Nuclear Information System (INIS)

    Goldstein, N.P.; Todt, W.H.

    1982-01-01

    A gamma-sensitive flux detector comprises tubular emitter, an insulating core within the emitter and an insulating layer about the emitter, and a tubular conductive collector electrode about the insulating layer. The emitter material may be platinum, lead, bismuth, tantalum, tungsten; platinum preferred

  9. Measurement of X-ray beam emittance using crystal optics at an X-ray undulator beamline

    CERN Document Server

    Kohmura, Y; Awaji, M; Tanaka, T; Hara, T; Goto, S; Ishikawa, T

    2000-01-01

    We present a method of using crystal optics to measure the emittance of the X-ray source. Two perfect crystals set in (++) configuration work as a high-resolution collimator. The phase-space diagram (i.e. beam cross-section and angular distribution) could be determined without any assumptions on the light source. When the measurement is done at short wavelength radiation from undulator, the electron beam emittance is larger than the diffraction limit of the X-rays. Therefore, the electron beam emittance could be estimated. The measurement was done with the hard X-rays of 18.5 and 55 keV from an undulator beamline, BL 47XU, of SPring-8. The horizontal emittance of the X-ray beam was estimated to be about 7.6 nmrad, close to the designed electron beam emittance of the storage ring (7 nmrad). Some portions of the instrumental functions, such as the scattering by filters and windows along the beamline and the slight bent of the crystal planes of the monochromator, could not be precisely evaluated, but an upper li...

  10. Minimization of the emittance growth of multi-charge particle beams in the charge stripping section of RAON

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Ji-Gwang [Department of Physics, Kyungpook National University, Daegu 702-701 (Korea, Republic of); Kim, Eun-San, E-mail: eskim1@knu.ac.kr [Department of Physics, Kyungpook National University, Daegu 702-701 (Korea, Republic of); Kim, Hye-Jin, E-mail: hjkim87@ibs.re.kr [Rare Isotope Science Project, Institute for Basic Science, Jeonmin-dong, Yuseong-gu, Daejeon (Korea, Republic of); Jeon, Dong-O [Rare Isotope Science Project, Institute for Basic Science, Jeonmin-dong, Yuseong-gu, Daejeon (Korea, Republic of)

    2014-12-11

    The charge stripping section of the Rare isotope Accelerator Of Newness (RAON), which is one of the critical components to achieve a high power of 400 kW with a short lianc, is a source of transverse emittance growth. The dominant effects are the angular straggling in the charge stripper required to increase the charge state of the beam and chromatic aberrations in the dispersive section required to separate the selected ion beam from the various ion beams produced in the stripper. Since the main source of transverse emittance growth in the stripper is the angular straggling, it can be compensated for by changing the angle of the phase ellipse. Therefore the emittance growth is minimized by optimizing the Twiss parameters at the stripper. The emittance growth in the charge selection section is also minimized by the correction of high-order aberrations using six sextupole magnets. In this paper, we present a method to minimize the transverse emittance growth in the stripper by changing the Twiss parameters and in the charge selection section by using sextupole magnets.

  11. A PILOT METHOD FOR MULTIMODAL GROUP THERAPY FOR ADULTS WITH ADHD

    Directory of Open Access Journals (Sweden)

    Alina Marin

    2014-11-01

    Full Text Available The management of ADHD across the lifespan is a topic of scientific and public debate, with much discussion centering on optimal treatments. Increasing empirical evidence suggests that successful management of ADHD involves a combination of stimulant medication and psychosocial interventions. This article describes an original approach combining multiple psychotherapeutic modalities that addresses the complex treatment requirements of adult patients with ADHD, through a structured, integrative, psychosocial therapeutic model that holistically encompasses problematic aspects of life for the adult with ADHD. This model integrates a range of methods, including, problem-solving therapy, mindfulness, cognitive-behavioral therapy (CBT and family therapy. Each of these methods have previously been empirically proven to be effective for this patient population, but have never been integrated into a coherent intervention comprised of group work designed for problem identification, positive reinforcement and modeling, peer discussions aimed to facilitate anger expression, communication and assertiveness training, and mindfulness and CBT exercises for increased awareness and organization, and to support new solutions for identified problems. Patients are also encouraged to identify trans-generational interaction patterns, reflect on how these patterns impact their emotional difficulties, and eventually achieve enhanced self-acceptance.

  12. Electromagnetic compatibility of implantable neurostimulators to RFID emitters.

    Science.gov (United States)

    Pantchenko, Oxana S; Seidman, Seth J; Guag, Joshua W; Witters, Donald M; Sponberg, Curt L

    2011-06-09

    The objective of this study is to investigate electromagnetic compatibility (EMC) of implantable neurostimulators with the emissions from radio frequency identification (RFID) emitters. Six active implantable neurostimulators with lead systems were tested for susceptibility to electromagnetic fields generated by 22 RFID emitters. These medical devices have been approved for marketing in the U.S. for a number of intended uses that include: epilepsy, depression, incontinence, Parkinsonian tremor and pain relief. Each RFID emitter had one of the following carrier frequencies: 125 kHz, 134 kHz, 13.56 MHz, 433 MHz, 915 MHz and 2.45 GHz. The test results showed the output of one of the implantable neurostimulators was inhibited by 134 kHz RFID emitter at separation distances of 10 cm or less. The output of the same implantable neurostimulator was also inhibited by another 134 kHz RFID emitter at separation distances of 10 cm or less and also showed inconsistent pulsing rate at a separation distance of 15 cm. Both effects occurred during and lasted through out the duration of the exposure. The clinical significance of the effects was assessed by a clinician at the U.S. Food and Drug Administration. The effects were determined to be clinically significant only if they occurred for extended period of time. There were no observed effects from the other 5 implantable neurostimulators or during exposures from other RFID emitters.

  13. Experimental investigation of thermal emittance components of copper photocathode

    Directory of Open Access Journals (Sweden)

    H. J. Qian

    2012-04-01

    Full Text Available With progress of photoinjector technology, thermal emittance has become the primary limitation of electron beam brightness. Extensive efforts have been devoted to study thermal emittance, but experiment results differ between research groups and few can be well interpreted. Besides the ambiguity of photoemission mechanism, variations of cathode surface conditions during cathode preparation, such as work function, field enhancement factor, and surface roughness, will cause thermal emittance differences. In this paper, we report an experimental study of electric field dependence of copper cathode quantum efficiency (QE and thermal emittance in a radio frequency (rf gun, through which in situ cathode surface parameters and thermal emittance contributions from photon energy, Schottky effect, and surface roughness are extracted. It is found the QE of a copper cathode illuminated by a 266 nm UV laser increased substantially to 1.5×10^{-4} after cathode cleaning during rf conditioning, and a copper work function of 4.16 eV, which is much lower than nominal value (4.65 eV, was measured. Experimental results also show a thermal emittance growth as much as 0.92  mm mrad/mm at 50  MV/m due to the cathode surface roughness effect, which is consistent with cathode surface morphology measurements.

  14. An Investigation of Emitters Clogging Under Magnetic Field and Water Quality

    Directory of Open Access Journals (Sweden)

    A. Kiani

    2016-02-01

    Full Text Available Introduction: Water scarcity is one of the major problems for crop production. Using drip irrigation as an effective method in the efficient use of water is expanding in arid and semi-arid regions. One of the problems in under pressure irrigation during use of saline, unconventional and waste is emitters clogging. There are several ways to prevent particle deposits in pipes and clogging of emitters. Generally, conventional methods are divided into two categories: physical and chemical methods. In physical method, suspended solids and inorganic materials are removed using particles sediment sand and disc filters. In the chemical method the pH drops by adding acid to water resulting in the dissolution of carbonate sediments. With chlorine handling, organisms (i.e. algae, fungi and bacteria that are the main causes of biological clogging are destroyed. However, the application of these methods is not successful in all cases. It has been observed that the emitters have gradually become obstructed. Magnetic water is obtained by passing water through permanent magnets or through the electromagnets installed in or on a feed pipeline. When a fluid passes through the magnetized field, its structure and some physical characteristic such as density, salt solution capacity, and deposition ratio of solid particles will be changed. An experimental study showed that a relatively weak magnetic influence increases the viscosity of water and consequently causes stronger hydrogen bonds under the magnetic field.There exist very few documented research projects related to the magnetization of water technology and its application to agricultural issues in general and emitter clogging in drip irrigation method, in particular. This technology is already used in some countries, especially in the Persian Gulf states. This research was designed and implemented aimed at increasing knowledge about the application of magnetic technology and its effects on emitters clogging

  15. Generic conditions for suppressing the coherent synchrotron radiation induced emittance growth in a two-dipole achromat

    Science.gov (United States)

    Jiao, Yi; Cui, Xiaohao; Huang, Xiyang; Xu, Gang

    2014-06-01

    The effect of the coherent synchrotron radiation (CSR) becomes evident, and leads to increased beam energy spread and transverse emittance dilution, as both the emittance and bunch length of the electron beams are continuously pushed down in present and forthcoming high-brightness light sources and linear colliders. Suppressing this effect is important to preserve the expected machine performance. Methods of the R-matrix analysis and the Courant-Snyder formalism analysis have been proposed to evaluate and to suppress the emittance growth due to CSR in achromatic cells. In this paper a few important modifications are made on these two methods, which enable us to prove that these two methods are equivalent to each other. With the modified analysis, we obtain explicit and generic conditions of cancelling the CSR-driven emittance excitation in a single achromat consisting of two dipoles of arbitrary bending angles. In spite of the fact that the analysis constrains itself in a linear regime, based on the assumption that CSR-induced particle energy deviation is proportional to both θ and ρ1/3, with θ being the bending angle and ρ the bending radius, it is demonstrated through ELEGANT simulations that the conditions derived from this analysis are still effective in suppressing the emittance growth when a more detailed one-dimensional CSR model is considered. In addition, it illustrates that the emittance growth can be reduced to a lower level with the proposed conditions than with the other two approaches, such as matching the beam envelope to the CSR kick and setting the cell-to-cell betatron phase advance to an appropriate value.

  16. Recent advances in the chemistry of positron emitters

    International Nuclear Information System (INIS)

    Wolf, A.P.; Fowler, J.S.

    1985-01-01

    With the increasing active interest in PET as a method for studying biochemistry in normal and pathological states in humans we can expect to see the development of new techniques for precursor preparation and synthesis. We have seen a doubling of the publication rate in the past three to four years over the previous three to four year period. As the need for these compounds, especially in the tumor and receptor areas, in a purely clinical setting, increases the trend towards true automation of production of the most needeed compounds will accelerate. The cyclotron manufacturers all offer ''black boxes'' for synthesis but the optimum approach to user friendly automation yet needs to be defined. I would note that this paper was not intended as a comprehensive review but rather my goal was to highlight just some of the exciting developments of the past several years. We are entering what may well be the most extensive and active period of research in the synthesis of positron emitter labeled compounds. If 1984 to 1985 is any gauge, many new methods and compounds will appear in the next several years. 37 refs

  17. Barium Depletion in Hollow Cathode Emitters

    Science.gov (United States)

    Polk, James E.; Capece, Angela M.; Mikellides, Ioannis G.; Katz, Ira

    2009-01-01

    The effect of tungsten erosion, transport and redeposition on the operation of dispenser hollow cathodes was investigated in detailed examinations of the discharge cathode inserts from an 8200 hour and a 30,352 hour ion engine wear test. Erosion and subsequent re-deposition of tungsten in the electron emission zone at the downstream end of the insert reduces the porosity of the tungsten matrix, preventing the ow of barium from the interior. This inhibits the interfacial reactions of the barium-calcium-aluminate impregnant with the tungsten in the pores. A numerical model of barium transport in the internal xenon discharge plasma shows that the barium required to reduce the work function in the emission zone can be supplied from upstream through the gas phase. Barium that flows out of the pores of the tungsten insert is rapidly ionized in the xenon discharge and pushed back to the emitter surface by the electric field and drag from the xenon ion flow. This barium ion flux is sufficient to maintain a barium surface coverage at the downstream end greater than 0.6, even if local barium production at that point is inhibited by tungsten deposits. The model also shows that the neutral barium pressure exceeds the equilibrium vapor pressure of the impregnant decomposition reaction over much of the insert length, so the reactions are suppressed. Only a small region upstream of the zone blocked by tungsten deposits is active and supplies the required barium. These results indicate that hollow cathode failure models based on barium depletion rates in vacuum dispenser cathodes are very conservative.

  18. Silicon Carbide Emitter Turn-Off Thyristor

    Directory of Open Access Journals (Sweden)

    Jun Wang

    2008-01-01

    Full Text Available A novel MOS-controlled SiC thyristor device, the SiC emitter turn-off thyristor (ETO is a promising technology for future high-voltage switching applications because it integrates the excellent current conduction capability of a SiC thyristor with a simple MOS-control interface. Through unity-gain turn-off, the SiC ETO also achieves excellent Safe Operation Area (SOA and faster switching speeds than silicon ETOs. The world's first 4.5-kV SiC ETO prototype shows a forward voltage drop of 4.26 V at 26.5 A/cm2 current density at room and elevated temperatures. Tested in an inductive circuit with a 2.5 kV DC link voltage and a 9.56-A load current, the SiC ETO shows a fast turn-off time of 1.63 microseconds and a low 9.88 mJ turn-off energy. The low switching loss indicates that the SiC ETO could operate at about 4 kHz if 100 W/cm2 conduction and the 100 W/cm2 turn-off losses can be removed by the thermal management system. This frequency capability is about 4 times higher than 4.5-kV-class silicon power devices. The preliminary demonstration shows that the SiC ETO is a promising candidate for high-frequency, high-voltage power conversion applications, and additional developments to optimize the device for higher voltage (>5 kV and higher frequency (10 kHz are needed.

  19. [The effectiveness of physical therapy methods (Bobath and motor relearning program) in rehabilitation of stroke patients].

    Science.gov (United States)

    Krutulyte, Grazina; Kimtys, Algimantas; Krisciūnas, Aleksandras

    2003-01-01

    The purpose of this study was to examine whether two different physiotherapy regimes caused any differences in outcome in the rehabilitation after stroke. We examined 240 patients with stroke. Examination was carried out at the Rehabilitation Center of Kaunas Second Clinical Hospital. Patients were divided into 2 groups: Bobath method was applied to the first (I) group (n=147), motor relearning program (MRP) method was applied to the second (II) group (n=93). In every group of patients we established samples according to sex, age, hospitalization to rehab unit as occurrence of CVA degree of disorder (hemiplegia, hemiparesis). The mobility of patients was evaluated according to European Federation for Research in Rehabilitation (EFRR) scale. Activities of daily living were evaluated by Barthel index. Analyzed groups were evaluated before physical therapy. When preliminary analysis was carried out it proved no statically reliable differences between analyzed groups (reliability 95%). The same statistical analysis was carried out after physical therapy. The results of differences between patient groups were compared using chi(2) method. Bobath method was applied working with the first group of patients. The aim of the method is to improve quality of the affected body side's movements in order to keep both sides working as harmoniously as possible. While applying this method at work, physical therapist guides patient's body on key-points, stimulating normal postural reactions, and training normal movement pattern. MRP method was used while working with the second group patients. This method is based on movement science, biomechanics and training of functional movement. Program is based on idea that movement pattern shouldn't be trained; it must be relearned. CONCLUSION. This study indicates that physiotherapy with task-oriented strategies represented by MRP, is preferable to physiotherapy with facilitation/inhibition strategies, such the Bobath programme, in the

  20. Current-horn suppression for reduced coherent-synchrotron-radiation-induced emittance growth in strong bunch compression

    Directory of Open Access Journals (Sweden)

    T. K. Charles

    2017-03-01

    Full Text Available Control of coherent synchrotron radiation (CSR-induced emittance growth is essential in linear accelerators designed to deliver very high brightness electron beams. Extreme current values at the head and tail of the electron bunch, resulting from strong bunch compression, are responsible for large CSR production leading to significant transverse projected emittance growth. The Linac Coherent Light Source (LCLS truncates the head and tail current spikes which greatly improves free electron laser (FEL performance. Here we consider the underlying dynamics that lead to formation of current spikes (also referred to as current horns, which has been identified as caustics forming in electron trajectories. We present a method to analytically determine conditions required to avoid the caustic formation and therefore prevent the current spikes from forming. These required conditions can be easily met, without increasing the transverse slice emittance, through inclusion of an octupole magnet in the middle of a bunch compressor.

  1. [Promising new injection method to prevent angialgia/phlebitis from epirubicin hydrochloride therapy for breast cancer].

    Science.gov (United States)

    Ono, Chiemi; Yamagami, Mitsue; Kamatani, Rika; Yamamoto, Makoto; Mukouyama, Tomoya; Sugimoto, Masakazu; Suzuki, Taizan; Kamo, Nobuyuki; Seki, Nobuhiko; Eguchi, Kenji; Ikeda, Tadashi

    2012-05-01

    Epirubicin hydrochloride(EPI)is well known to cause phlebitis as a typical adverse drug reaction. By preventing the development of severe phlebitis, patients are expected to continue effective chemotherapy with EPI without a decrease in QOL. We have previously reported promising results of a new injection method to prevent phlebitis from occurring during EPI therapy thorough a prospective clinical trial in our hospital(Jpn J Cancer Chemother 36: 969-974, 2009). In the present study, we have compared the conventional injection method(EPI main -route method, n=15)with our new method, which has been consistently practiced at present(EPI sub -route method, n=77). We found that in the EPI main -route method, angialgia/phlebitis developed in 14 of 15 cases(Grade 3, 53. 3%), leading to alteration of the regimen in 3 cases. On the other hand, with the EPI sub -route method, incidence of angialgia/phlebitis was markedly decreased, and only 6 of 77 cases developed these adverse reactions(Grade 3, 0%). One possible explanation for these results is that the reduction of intimal stimulation by the EPI sub -route method might be caused by the dilution and washout of EPI with pre-medication, as well as the shortened infusion times of EPI. Therefore, on the basis of the above hypothesis, we conclude that the EPI sub-route method might be a more effective treatment for the expected prevention of angialgia/phlebitis.

  2. Combining surface plasmonic and light extraction enhancement on InGaN quantum-well light-emitters

    DEFF Research Database (Denmark)

    Fadil, Ahmed; Ou, Yiyu; Iida, Daisuke

    2016-01-01

    and internal quantum efficiency enhancement for InGaN/GaN quantum-well light-emitters. By fabricating dielectric nano-rod pattern on the GaN surface, an optical coating that improves the light extraction is obtained, and furthermore has a low refractive index which blue-shifts the plasmonic resonance of Ag NPs......Surface plasmon coupling with light-emitters and surface nano-patterning have widely been used separately to improve low efficiency InGaN light-emitting diodes. We demonstrate a method where dielectric nano-patterning and Ag nanoparticles (NPs) are combined to provide both light extraction...

  3. Endoscopic Therapy of Refractory Post-Papillotomy Bleeding With Electrocautery Forceps Coagulation Method Combined With Prophylactic Pancreatic Stenting

    Directory of Open Access Journals (Sweden)

    Zsolt Dubravcsik

    2014-01-01

    Conclusion: We presented a new, effective and safe second line endoscopic hemostatic method in patients with therapy resistant post-papillotomy bleeding. Combination of prophylactic pancreatic stenting and thermal coagulation with coagulation forceps might be suggested as a rescue treatment in patients with severe post-papillotomy bleeding, resistant to standard endoscopic therapy.

  4. Demonstration of a laserwire emittance scanner for hydrogen ion beams at CERN

    CERN Document Server

    Hofmann, Thomas; Bosco, A.; Gibson, S.M.; Roncarolo, F.; Boorman, G.; Raich, U.; Bravin, E.; Pozimski, J.K.; Letchford, A.; Gabor, C.

    2015-12-21

    A non-invasive, compact laserwire system has been developed to measure the transverse emittance of an H- beam and has been demonstrated at the new LINAC4 injector for the LHC at CERN. Light from a low power, pulsed laser source is conveyed via fibre to collide with the H- beam, a fraction of which is neutralized and then intercepted by a downstream diamond detector. Scanning the focused laser across the H- beam and measuring the distribution of the photo-neutralized particles enables the transverse emittance to be reconstructed. The vertical phase-space distribution of a 3 MeV beam during LINAC4 commissioning has been measured by the laserwire and verified with a conventional slit and grid method.

  5. Electrode system design for acceleration of ion beam of given initial emittance

    International Nuclear Information System (INIS)

    Dzmuran, R.; Kuzmiak, M.; Novy, F.

    1986-01-01

    A method is described for calculating beam optical equipment, proceeding from the fact that the motion of the ion beam is in fact a transmission of emittance in the direction of the motion. The calculation of the transmission of emittance is simplified when we assume the transmission in the form of erect phase ellipses. The calculation procedure was used to design a system of electrodes for ion beam acceleration, consisting of three thick electrostatic lenses: an extracting, an accomodating and an accelerating lens. A graphical representation is given of the transmission of the erect phase ellipse through the individual lenses and through the whole system, and tabulated are values of the beam divergence, both in dependence on the voltage ratio on the electrodes. (A.K.)

  6. Demonstration of a laserwire emittance scanner for hydrogen ion beams at CERN

    Directory of Open Access Journals (Sweden)

    T. Hofmann

    2015-12-01

    Full Text Available A noninvasive, compact laserwire system has been developed to measure the transverse emittance of an H^{-} beam and has been demonstrated at the new LINAC4 injector for the LHC at CERN. Light from a low power, pulsed laser source is conveyed via fiber to collide with the H^{-} beam, a fraction of which is neutralized and then intercepted by a downstream diamond detector. Scanning the focused laser across the H^{-} beam and measuring the distribution of the photo-neutralized particles enables the transverse emittance to be reconstructed. The vertical phase-space distribution of a 3 MeV beam during LINAC4 commissioning has been measured by the laserwire and verified with a conventional slit and grid method.

  7. Noninterceptive transverse emittance measurements using BPM for Chinese ADS R&D project

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhi-Jun, E-mail: wangzj@impcas.ac.cn [Institute of Modern Physics, The Chinese Academy of Sciences, Lanzhou 73000 (China); Feng, Chi [Institute of Modern Physics, The Chinese Academy of Sciences, Lanzhou 73000 (China); He, Yuan, E-mail: hey@impcas.ac.cn [Institute of Modern Physics, The Chinese Academy of Sciences, Lanzhou 73000 (China); Dou, Weiping [Institute of Modern Physics, The Chinese Academy of Sciences, Lanzhou 73000 (China); Tao, Yue; Chen, Wei-long [Institute of Modern Physics, The Chinese Academy of Sciences, Lanzhou 73000 (China); University of the Chinese Academy of Sciences, Beijing 100049 (China); Jia, Huan; Liu, Shu-hui; Wang, Wang-sheng; Zhang, Yong; Wu, Jian-qiang; Zhang, Sheng-hu; Zhang, X.L. [Institute of Modern Physics, The Chinese Academy of Sciences, Lanzhou 73000 (China)

    2016-04-21

    The noninterceptive four-dimensional transverse emittance measurements are essential for commissioning the high power continue-wave (CW) proton linacs as well as their operations. The conventional emittance measuring devices such as slits and wire scanners are not well suited under these conditions due to sure beam damages. Therefore, the method of using noninterceptive Beam Position Monitor (BPM) is developed and demonstrated on Injector Scheme II at the Chinese Accelerator Driven Sub-critical System (China-ADS) proofing facility inside Institute of Modern Physics (IMP) [1]. The results of measurements are in good agreements with wire scanners and slits at low duty-factor pulsed (LDFP) beam. In this paper, the detailed experiment designs, data analysis and result benchmarking are presented.

  8. An emittance measurement system for a wide range of bunch charges

    International Nuclear Information System (INIS)

    Dunham, B.; Engwall, D.; Hofler, A.; Keesee, M.; Legg, R.

    1997-01-01

    As a part of the emittance measurements planned for the FEL injector at the Thomas Jefferson National Accelerator Facility (Jefferson Lab), the authors have developed an emittance measurement system that covers the wide dynamic range of bunch charges necessary to fully characterize the high-DC-voltage photocathode gun. The measurements are carried out with a variant of the classical two-slit method using a slit to sample the beam in conjunction with a wire scanner to measure the transmitted beam profile. The use of commercial, ultra-low noise picoammeters makes it possible to cover the wide range of desired bunch charges, with the actual measurements made over the range of 0.25 pC to 125 pC. The entire system, including its integration into the EPICS control system, is discussed

  9. Continuous-wave optically pumped green perovskite vertical-cavity surface-emitter

    KAUST Repository

    Alias, Mohd Sharizal

    2017-09-11

    We report an optically pumped green perovskite vertical-cavity surface-emitter operating in continuous-wave (CW) with a power density threshold of ~89 kW/cm2. The device has an active region of CH3NH3PbBr3 embedded in a dielectric microcavity; this feat was achieved with a combination of optimal spectral alignment of the optical cavity modes with the perovskite optical gain, an adequate Q-factor of the microcavity, adequate thermal stability, and improved material quality with a smooth, passivated, and annealed thin active layer. Our results signify a way towards efficient CW perovskite emitter operation and electrical injection using low-cost fabrication methods for addressing monolithic optoelectronic integration and lasing in the green gap.

  10. Improving Defect-Based Quantum Emitters in Silicon Carbide via Inorganic Passivation.

    Science.gov (United States)

    Polking, Mark J; Dibos, Alan M; de Leon, Nathalie P; Park, Hongkun

    2018-01-01

    Defect-based color centers in wide-bandgap crystalline solids are actively being explored for quantum information science, sensing, and imaging. Unfortunately, the luminescent properties of these emitters are frequently degraded by blinking and photobleaching that arise from poorly passivated host crystal surfaces. Here, a new method for stabilizing the photoluminescence and charge state of color centers based on epitaxial growth of an inorganic passivation layer is presented. Specifically, carbon antisite-vacancy pairs (CAV centers) in 4H-SiC, which serve as single-photon emitters at visible wavelengths, are used as a model system to demonstrate the power of this inorganic passivation scheme. Analysis of CAV centers with scanning confocal microscopy indicates a dramatic improvement in photostability and an enhancement in emission after growth of an epitaxial AlN passivation layer. Permanent, spatially selective control of the defect charge state can also be achieved by exploiting the mismatch in spontaneous polarization at the AlN/SiC interface. These results demonstrate that epitaxial inorganic passivation of defect-based quantum emitters provides a new method for enhancing photostability, emission, and charge state stability of these color centers. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Suppression of the emittance growth induced by coherent synchrotron radiation in triple-bend achromats

    International Nuclear Information System (INIS)

    Huang Xiyang; Jiao Yi; Xu Gang; Cui Xiaohao

    2015-01-01

    The coherent synchrotron radiation (CSR) effect in a bending path plays an important role in transverse emittance dilution in high-brightness light sources and linear colliders, where the electron beams are of short bunch length and high peak current. Suppression of the emittance growth induced by CSR is critical to preserve the beam quality and help improve the machine performance. It has been shown that the CSR effect in a double-bend achromat (DBA) can be analyzed with the two-dimensional point-kick analysis method. In this paper, this method is applied to analyze the CSR effect in a triple-bend achromat (TBA) with symmetric layout, which is commonly used in the optics designs of energy recovery linacs (ERLs). A condition of cancelling the CSR linear effect in such a TBA is obtained, and is verified through numerical simulations. It is demonstrated that emittance preservation can be achieved with this condition, and to a large extent, has a high tolerance to the fluctuation of the initial transverse phase space distribution of the beam. (authors)

  12. Single-Particle Dynamics in Electron Storage Rings with Extremely Low Emittance

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Yunhai; /SLAC

    2011-05-31

    Electron storage rings are widely used for high luminosity colliders, damping rings in high-energy linear colliders, and synchrotron light sources. They have become essential facilities to study high-energy physics and material and medical sciences. To further increase the luminosity of colliders or the brightness of synchrotron light sources, the beam emittance is being continually pushed downward, recently to the nanometer region. In the next decade, another order of reduction is expected. This requirement of ultra-low emittance presents many design challenges in beam dynamics, including better analysis of maps and improvement of dynamic apertures. To meet these challenges, we have refined transfer maps of common elements in storage rings and developed a new method to compute the resonance driving terms as they are built up along a beamline. The method is successfully applied to a design of PEP-X as a future light source with 100-pm emittance. As a result, we discovered many unexpected cancelations of the fourth-order resonance terms driven by sextupoles within an achromat.

  13. Cognitive Behavioral Therapy, Mindfulness, and Hypnosis as Treatment Methods for Generalized Anxiety Disorder.

    Science.gov (United States)

    Daitch, Carolyn

    2018-07-01

    Individuals suffering from generalized anxiety disorder (GAD) experience a broad range of physical, emotional, and cognitive distress. A hallmark of GAD is anxiety around making decisions. Many clinicians notice improvements in patients through specific modalities, such as mindfulness, hypnosis, and cognitive behavioral therapy (CBT); however, these individual methods sometimes fall short. Clinicians and researchers alike note that it can be more effective to combine these three methods into an integrative treatment protocol. This article demonstrates the efficacy of an integrative model through the case study of a client who suffers from GAD and acute fear of decision making. Competent use of mindfulness, hypnosis, and CBT helps the client build the skills necessary to self-soothe, diminish worry, access resources, and enhance hope for the future. Through the article, clinicians interested in integrated treatment models will gain insight into how to apply these methods.

  14. A method to select aperture margin in collimated spot scanning proton therapy

    International Nuclear Information System (INIS)

    Wang, Dongxu; Smith, Blake R; Gelover, Edgar; Flynn, Ryan T; Hyer, Daniel E

    2015-01-01

    The use of collimator or aperture may sharpen the lateral dose gradient for spot scanning proton therapy. However, to date, there has not been a standard method to determine the aperture margin for a single field in collimated spot scanning proton therapy. This study describes a theoretical framework to select the optimal aperture margin for a single field, and also presents the spot spacing limit required such that the optimal aperture margin exists. Since, for a proton pencil beam partially intercepted by collimator, the maximum point dose (spot center) shifts away from the original pencil beam central axis, we propose that the optimal margin should be equal to the maximum pencil beam center shift under the condition that spot spacing is small with respect to the maximum pencil beam center shift, which can be numerically determined based on beam modeling data. A test case is presented which demonstrates agreement with the prediction made based on the proposed methods. When apertures are applied in a commercial treatment planning system this method may be implemented. (note)

  15. Measurement of anatomy contouring in EPI review: a practical method for use in radiation therapy departments

    International Nuclear Information System (INIS)

    Halkett, Georgia; Williams, Marie

    2004-01-01

    Radiation therapy treatment verification can be performed using hard copy portal films or digital Electronic Portal Images (EPI) of the treatment field, acquired at the time of treatment. This paper describes a practical method of assessing the accuracy of reference anatomy outlining, for treatment sites involving the pelvis, breast and lumbar spine. Seven original bone anatomy outlines contoured onto verification images of five patients, were printed on transparency sheets and reference points were marked at equal distances along the anatomy curves. Two sample anatomy contour sets were created by two independent radiation therapists who outlined visible bone anatomy on the same seven digitally reconstructed radiographs (DRR) and hard copy outlines were obtained. Three independent observers with differing levels of experience, assessed the discrepancies between the original anatomy contours and the sample sets on two occasions one week apart, by measuring the distances between the original and sample set contours (absolute values in mm). The degree of agreement between the same assessor on two occasions (intra-rater reliability) and between assessors (inter-rater reliability) was analysed using parametric analysis for levels of relationship and significant differences. This simple method of reference anatomy outline measurement was shown to be highly reliable within assessors and between assessors (r > 0.87 and rz > 0.75 for both intra- and inter-rater comparisons). This measurement process may be a suitable method, for undertaking quality assurance activities in image verification within radiation therapy departments. Copyright (2004) Australian Institute of Radiography

  16. Nuclear medicine. Clinical value of the medicine methods. Nuklearmedizin. Klinische Bedeutung nuklearmedizinischer Diagnostik und Therapie

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, H A.E. [Evangelisches Krankenhaus Bethesda Gemeinnuetzige G.m.b.H., Duisburg (Germany, F.R.). Nuklearmedizinische Klinik und Poliklinik; Ortiz Berrocal, J [Universidad Autonoma de Madrid (Spain). Dept. of Nuclear Medicine; eds.

    1979-01-01

    This proceedings volume of the 16th International Annual Meeting of the Gesellschaft fuer Nuklearmedizin, which took place in Madrid on October 24-27, 1978, contains 183 compacts on the following subjects: Metrology and data processing, cyclotron products and radiopharmaceuticals, nuclear medicine as compared with computerized tomography and sonography, radioimmunoassay, haematology, thyreology, osteology, pulmonology, cardiology, angiology, nephrology, gastroenterology and hepatology, oncology, nuclear therapy methods and some free lectures and thus give a good picture of the state of the art in nuclear medicine at the time.

  17. Magnet design for a low-emittance storage ring

    Science.gov (United States)

    Johansson, Martin; Anderberg, Bengt; Lindgren, Lars-Johan

    2014-01-01

    The MAX IV 3 GeV storage ring, currently under construction, pursues the goal of low electron beam emittance by using a multi-bend achromat magnet lattice, which is realised by having several consecutive magnet elements precision-machined out of a common solid iron block, 2.3–3.4 m long. With this magnet design solution, instead of having 1320 individual magnets, the MAX IV 3 GeV storage ring is built up using 140 integrated ‘magnet block’ units, containing all these magnet elements. Major features of this magnet block design are compactness, vibration stability and that the alignment of magnet elements within each unit is given by the mechanical accuracy of the CNC machining rather than individual field measurement and adjustment. This article presents practical engineering details of implementing this magnet design solution, and mechanical + magnetic field measurement results from the magnet production series. At the time of writing (spring 2014), the production series, which is totally outsourced to industry, is roughly half way through, with mechanical/magnetic QA conforming to specifications. It is the conclusion of the authors that the MAX IV magnet block concept, which has sometimes been described as new or innovative, is from a manufacturing point of view simply a collection of known mature production methods and measurement procedures, which can be executed at fixed cost with a low level of risk. PMID:25177980

  18. A multiwire secondary emission profile monitor for small emittance beams

    International Nuclear Information System (INIS)

    Chehab, R.; Bonnard, J.; Humbert, G.; Leblond, B.; Saury, J.L.

    1985-01-01

    A secondary emission monitor using two multiwire grids separated by a positively biased collector has been constructed and tested with a 1 GeV electron beam at the Orsay Linac. The monitor installed just before the electron-positron converter has 8 gold-plated-tungsten wires of 0.1 mm diameter equally spaced 0.2 mm apart in each plane. Each wire is connected with an integrator using a low-bias current operational amplifier. The wire planes and the collector are moved into the beam by a stepping motor : that allows beam-position verification. We measured narrow profiles for 1 Amp peak current pulses of 30 nanoseconds width. Profiles are displayed on a scope and allow emittance determination by the three gradient method. Such a monitor is very useful to control the electron beam position and dimensions on the converter, because the positron source dimensions are rather bigger than those of the incident beam and the geometrical acceptance of the positron Linac is limited

  19. Analysis of Urine for Pure Beta Emitters: Methods and Application

    DEFF Research Database (Denmark)

    Hou, Xiaolin

    2011-01-01

    Bioassay for individual radionuclides is an essential and first step in estimation of radiation risk to nuclear facilities workers and people who are exposed to the contaminated environment in the event of a nuclear accident or radiological attack. Urine is a frequently used biological sample for...

  20. Inpatient Massage Therapy Versus Music Therapy Versus Usual Care: A Mixed-methods Feasibility Randomized Controlled Trial.

    Science.gov (United States)

    Roseen, Eric J; Cornelio-Flores, Oscar; Lemaster, Chelsey; Hernandez, Maria; Fong, Calvin; Resnick, Kirsten; Wardle, Jon; Hanser, Suzanne; Saper, Robert

    2017-01-01

    Little is known about the feasibility of providing massage or music therapy to medical inpatients at urban safety-net hospitals or the impact these treatments may have on patient experience. To determine the feasibility of providing massage and music therapy to medical inpatients and to assess the impact of these interventions on patient experience. Single-center 3-arm feasibility randomized controlled trial. Urban academic safety-net hospital. Adult inpatients on the Family Medicine ward. Massage therapy consisted of a standardized protocol adapted from a previous perioperative study. Music therapy involved a preference assessment, personalized compact disc, music-facilitated coping, singing/playing music, and/or songwriting. Credentialed therapists provided the interventions. Patient experience was measured with the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) within 7 days of discharge. We compared the proportion of patients in each study arm reporting "top box" scores for the following a priori HCAHPS domains: pain management, recommendation of hospital, and overall hospital rating. Responses to additional open-ended postdischarge questions were transcribed, coded independently, and analyzed for common themes. From July to December 2014, 90 medical inpatients were enrolled; postdischarge data were collected on 68 (76%) medical inpatients. Participants were 70% females, 43% non-Hispanic black, and 23% Hispanic. No differences between groups were observed on HCAHPS. The qualitative analysis found that massage and music therapy were associated with improved overall hospital experience, pain management, and connectedness to the massage or music therapist. Providing music and massage therapy in an urban safety-net inpatient setting was feasible. There was no quantitative impact on HCAHPS. Qualitative findings suggest benefits related to an improved hospital experience, pain management, and connectedness to the massage or music therapist.

  1. Inpatient Massage Therapy Versus Music Therapy Versus Usual Care: A Mixed-methods Feasibility Randomized Controlled Trial

    Science.gov (United States)

    Cornelio-Flores, Oscar; Lemaster, Chelsey; Hernandez, Maria; Fong, Calvin; Resnick, Kirsten; Wardle, Jon; Hanser, Suzanne; Saper, Robert

    2017-01-01

    Background Little is known about the feasibility of providing massage or music therapy to medical inpatients at urban safety-net hospitals or the impact these treatments may have on patient experience. Objective To determine the feasibility of providing massage and music therapy to medical inpatients and to assess the impact of these interventions on patient experience. Design Single-center 3-arm feasibility randomized controlled trial. Setting Urban academic safety-net hospital. Patients Adult inpatients on the Family Medicine ward. Interventions Massage therapy consisted of a standardized protocol adapted from a previous perioperative study. Music therapy involved a preference assessment, personalized compact disc, music-facilitated coping, singing/playing music, and/or songwriting. Credentialed therapists provided the interventions. Measurements Patient experience was measured with the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) within 7 days of discharge. We compared the proportion of patients in each study arm reporting “top box” scores for the following a priori HCAHPS domains: pain management, recommendation of hospital, and overall hospital rating. Responses to additional open-ended postdischarge questions were transcribed, coded independently, and analyzed for common themes. Results From July to December 2014, 90 medical inpatients were enrolled; postdischarge data were collected on 68 (76%) medical inpatients. Participants were 70% females, 43% non-Hispanic black, and 23% Hispanic. No differences between groups were observed on HCAHPS. The qualitative analysis found that massage and music therapy were associated with improved overall hospital experience, pain management, and connectedness to the massage or music therapist. Conclusions Providing music and massage therapy in an urban safety-net inpatient setting was feasible. There was no quantitative impact on HCAHPS. Qualitative findings suggest benefits related to an

  2. Emittance growth and tune spectra at PETRA III

    International Nuclear Information System (INIS)

    Wanzenberg, R.

    2011-08-01

    At DESY the PETRA ring has been converted into a synchrotron radiation facility, called PETRA III. 20 damping wigglers have been installed to achieve an emittance of 1 nm. The commissioning with beam started in April 2009 and user runs have been started in 2010. The design current is 100 mA and the bunch to bunch distance is 8 ns for one particular filling pattern with 960 bunches. At a current of about 50 mA a strong vertical emittance increase has been observed. During machine studies it was found that the emittance increase depends strongly on the bunch filling pattern. For the user operation a filling scheme has been found which mitigates the increase of the vertical emittance. In August 2010 PETRA III has been operated without damping wigglers for one week. The vertical emittance growth was not significantly smaller without wigglers. Furthermore tune spectra at PETRA III show characteristic lines which have been observed at other storage rings in the connection with electron clouds. Measurements at PETRA III are presented for different bunch filling patterns and with and without wiggler magnets. (orig.)

  3. Measurement of transverse emittance in the Fermilab booster

    Energy Technology Data Exchange (ETDEWEB)

    Graves, William Sproull [Wisconsin U., Madison

    1994-01-01

    A new beam profile monitor has been built and installed in the Fermilab Booster synchrotron. It nondestructively measures the beam's vertical density distribution on a fast turn-by-turn basis. This enables one to measure the beam's transverse emittance and to observe emittance growth as it occurs. For high intensities (>2 times 10^{12 } protons), the normalized 95% emittance was observed to grow from 6pi mm-mrad at injection to 16pi mm-mrad at extraction. The initial (<5 msec) emittance growth and beam losses are shown to be caused by the space charge tune shift onto integer and 1/2 integer resonance lines. The growth near injection accounts for approximately 40% of the observed emittance increase throughout the acceleration cycle. The remaining 60% is due to two factors: slow linear growth due to betatron-motion driven by noise in the rf system; and faster growth after the transition energy that is caused by coupling of the longitudinal beam motion into the transverse planes.

  4. Transverse emittance growth in staged laser-wakefield acceleration

    Directory of Open Access Journals (Sweden)

    T. Mehrling

    2012-11-01

    Full Text Available We present a study on the emittance evolution of electron bunches, externally injected into laser-driven plasma waves using the three-dimensional particle-in-cell (PIC code OSIRIS. Results show order-of-magnitude transverse emittance growth during the injection process, if the electron bunch is not matched to its intrinsic betatron motion inside the wakefield. This behavior is supported by analytic theory reproducing the simulation data to a percent level. The length over which the full emittance growth develops is found to be less than or comparable to the typical dimension of a single plasma module in current multistage designs. In addition, the analytic theory enables the quantitative prediction of emittance degradation in two consecutive accelerators coupled by free-drift sections, excluding this as a scheme for effective emittance-growth suppression, and thus suggests the necessity of beam-matching sections between acceleration stages with fundamental implications on the overall design of staged laser-wakefield accelerators.

  5. Emittance measurements in Grumman 1 MeV beamline

    International Nuclear Information System (INIS)

    Debiak, T.; Gammel, G.; Melnychuk, S.

    1992-01-01

    The emittance of a 30 keV H - beam has been measured with an Allison type electrostatic analyser at two positions separated by 85 cm along the Grumman 1 MeV beamline LEBT at low currents (about 4 mA, no Cs 2 O additive in the source) and at higher currents (10-15 mA, with Cs 2 O additive in the source). No emittance growth was observed between the two positions, but, at the higher current level, the emittance was about 60% higher than at the low current level (Σ n ,rms = .0045 π cm-mrad vs. 0070 π cm-mrad). Argon was then introduced up to a partial pressure of 4x10 -5 torr, and the emittance decreased back to a range corresponding to that found at the lower currents. However, beam noise was observed at the downstream position, and there is evidence for a small amount of emittance growth (<20%) between the two positions

  6. A mixed methods analysis of songs written by bereaved preadolescents in individual music therapy.

    Science.gov (United States)

    Roberts, Melina; McFerran, Katrina

    2013-01-01

    Providing opportunities for children to process loss and express grief in response to the loss of a loved one has been shown to assist with successful coping (Worden, 1996). Songwriting may be a relevant method that fosters the expression of thoughts and feelings related to the loss. The purpose of this study was to analyse lyrics written by bereaved children during individual music therapy and to determine if they did use the opportunity to address grief through songwriting. Participants were 14 bereaved children (13 girls, 1 boy) aged between 7 and 12 years. Children were recruited and participated in individual music therapy in their homes with a credentialed music therapist. Participants wrote a total of 49 songs and their lyrics were analysed using a mixed methods content analysis. An inductive analysis identified categories existing within the lyrics and each lyric was then deductively attributed to one of the categories. Results revealed that the children wrote songs about themselves, their experiences, and their relationships, including, but not limited to the topic of loss. It became apparent that through songwriting these children expressed their experiences of the world based on their developmental capacities and limitations.

  7. Nanowires-based light emitters on thermally and electrically conductive substrates and of making same

    KAUST Repository

    Ooi, Boon S.; Zhao, Chao; Ng, Tien Khee

    2017-01-01

    Elemental or compound semiconductors on metal substrates and methods of growing them are provided. The methods can include the steps of: (i) providing a metal substrate; (ii) adding an interlayer on a surface of the metal substrate, and (iii) growing semiconductor nanowires on the interlayer using a semiconductor epitaxy growth system to form the elemental or compound semiconductor. The method can include direct growth of high quality group III-V and group III-N based materials in the form of nanowires and nanowires-based devices on metal substrates. The nanowires on all- metal scheme greatly simplifies the fabrication process of nanowires based high power light emitters.

  8. Nanowires-based light emitters on thermally and electrically conductive substrates and of making same

    KAUST Repository

    Ooi, Boon S.

    2017-04-27

    Elemental or compound semiconductors on metal substrates and methods of growing them are provided. The methods can include the steps of: (i) providing a metal substrate; (ii) adding an interlayer on a surface of the metal substrate, and (iii) growing semiconductor nanowires on the interlayer using a semiconductor epitaxy growth system to form the elemental or compound semiconductor. The method can include direct growth of high quality group III-V and group III-N based materials in the form of nanowires and nanowires-based devices on metal substrates. The nanowires on all- metal scheme greatly simplifies the fabrication process of nanowires based high power light emitters.

  9. Commissioning of the SPARC Movable Emittance Meter and Its First Operation at PITZ

    CERN Document Server

    Catani, L; Cianchi, A

    2005-01-01

    For the SPARC Project a novel diagnostic device, called "Emittance-meter", has been conceived and constructed to perform a detailed study of the emittance compensation process in the SPARC photo-injector and to optimize the RF-gun and the accelerator working point. It consists of a movable emittance measurement system, based on the 1D pepper-pot method, installed between two long bellows with the possibility to scan a region 1.5 m long downstream the RF-gun. The construction of the device was completed in the first part of this year and a series of laboratory tests, to evaluate its performances, were carried out in Spring 2005. At the beginning of the summer the complete system was moved to DESY at Zeuthen to be installed on the Photo Injector Test Facility PITZ. After the commissioning it will used for measurements of the PITZ electron beam in the framework of a collaboration between the SPARC and PITZ Projects aiming on studies and operations with photo injectors.

  10. Space Charge Correction on Emittance Measurement of Low Energy Electron Beams

    Energy Technology Data Exchange (ETDEWEB)

    Treado, Colleen J.; /Massachusetts U., Amherst

    2012-09-07

    The goal of any particle accelerator is to optimize the transport of a charged particle beam along a set path by confining the beam to a small region close to the design trajectory and directing it accurately along the beamline. To do so in the simplest fashion, accelerators use a system of magnets that exert approximately linear electromagnetic forces on the charged beam. These electromagnets bend the beam along the desired path, in the case of bending magnets, and constrain the beam to the desired area through alternating focusing and defocusing effects, in the case of quadrupole magnets. We can model the transport of such a beam through transfer matrices representing the actions of the various beamline elements. However, space charge effects, produced from self electric fields within the beam, defocus the beam and must be accounted for in the calculation of beam emittance. We present below the preliminary results of a MATLAB code built to model the transport of a charged particle beam through an accelerator and measure the emittance under the influence of space charge effects. We demonstrate the method of correctly calculating the emittance of a beam under space charge effects using a least square fit to determine the initial properties of the beam given the beam size measured at a specific point after transport.

  11. Real-time radionuclide identification in γ-emitter mixtures based on spiking neural network

    International Nuclear Information System (INIS)

    Bobin, C.; Bichler, O.; Lourenço, V.; Thiam, C.; Thévenin, M.

    2016-01-01

    Portal radiation monitors dedicated to the prevention of illegal traffic of nuclear materials at international borders need to deliver as fast as possible a radionuclide identification of a potential radiological threat. Spectrometry techniques applied to identify the radionuclides contributing to γ-emitter mixtures are usually performed using off-line spectrum analysis. As an alternative to these usual methods, a real-time processing based on an artificial neural network and Bayes’ rule is proposed for fast radionuclide identification. The validation of this real-time approach was carried out using γ-emitter spectra ( 241 Am, 133 Ba, 207 Bi, 60 Co, 137 Cs) obtained with a high-efficiency well-type NaI(Tl). The first tests showed that the proposed algorithm enables a fast identification of each γ-emitting radionuclide using the information given by the whole spectrum. Based on an iterative process, the on-line analysis only needs low-statistics spectra without energy calibration to identify the nature of a radiological threat. - Highlights: • A fast radionuclide identification algorithm applicable in spectroscopic portal monitors is presented. • The proposed algorithm combines a Bayesian sequential approach and a spiking neural network. • The algorithm was validated using the mixture of γ-emitter spectra provided by a well-type NaI(Tl) detector. • The radionuclide identification process is implemented using the whole γ-spectrum without energy calibration.

  12. A correction for emittance-measurement errors caused by finite slit and collector widths

    International Nuclear Information System (INIS)

    Connolly, R.C.

    1992-01-01

    One method of measuring the transverse phase-space distribution of a particle beam is to intercept the beam with a slit and measure the angular distribution of the beam passing through the slit using a parallel-strip collector. Together the finite widths of the slit and each collector strip form an acceptance window in phase space whose size and orientation are determined by the slit width, the strip width, and the slit-collector distance. If a beam is measured using a detector with a finite-size phase-space window, the measured distribution is different from the true distribution. The calculated emittance is larger than the true emittance, and the error depends both on the dimensions of the detector and on the Courant-Snyder parameters of the beam. Specifically, the error gets larger as the beam drifts farther from a waist. This can be important for measurements made on high-brightness beams, since power density considerations require that the beam be intercepted far from a waist. In this paper we calculate the measurement error and we show how the calculated emittance and Courant-Snyder parameters can be corrected for the effects of finite sizes of slit and collector. (Author) 5 figs., 3 refs

  13. Overview of laserwire beam profile and emittance measurements for high power proton accelerators

    CERN Document Server

    Gibson, S M; Bosco, A; Gabor, C; Pozimski, J; Savage, P; Hofmann, T

    2013-01-01

    Laserwires were originally developed to measure micron-sized electron beams via Compton scattering, where traditional wire scanners are at the limit of their resolution. Laserwires have since been applied to larger beamsize, high power H$^-$ ion beams, where the non-invasive method can probe beam densities that would damage traditional diagnostics. While photo-detachment of H$^-$ ions is now routine to measure beam profiles, extending the technique to transverse and longitudinal emittance measurements is a key aim of the laserwire emittance scanner under construction at the Front End Test Stand (FETS) at the RAL. A pulsed, 30 kHz, 8kW peak power laser is fibrecoupled to motorized collimating optics, which controls the position and thickness of the laserwire delivered to the H- interaction chamber. The laserwire slices out a beamlet of neutralized particles, which propagate to a downstream scintillator and camera. The emittance is reconstructed from 2D images as the laserwire position is scanned. Results from ...

  14. Mathematical design of a novel input/instruction device using a moving acoustic emitter

    Science.gov (United States)

    Wang, Xianchao; Guo, Yukun; Li, Jingzhi; Liu, Hongyu

    2017-10-01

    This paper is concerned with the mathematical design of a novel input/instruction device using a moving emitter. The emitter acts as a point source and can be installed on a digital pen or worn on the finger of the human being who desires to interact/communicate with the computer. The input/instruction can be recognized by identifying the moving trajectory of the emitter performed by the human being from the collected wave field data. The identification process is modelled as an inverse source problem where one intends to identify the trajectory of a moving point source. There are several salient features of our study which distinguish our result from the existing ones in the literature. First, the point source is moving in an inhomogeneous background medium, which models the human body. Second, the dynamical wave field data are collected in a limited aperture. Third, the reconstruction method is independent of the background medium, and it is totally direct without any matrix inversion. Hence, it is efficient and robust with respect to the measurement noise. Both theoretical justifications and computational experiments are presented to verify our novel findings.

  15. Transverse emittance and phase space program developed for use at the Fermilab A0 Photoinjector

    International Nuclear Information System (INIS)

    Thurman-Keup, R.; Johnson, A.S.; Lumpkin, A.H.; Ruan, J.

    2011-01-01

    The Fermilab A0 Photoinjector is a 16 MeV high intensity, high brightness electron linac developed for advanced accelerator R and D. One of the key parameters for the electron beam is the transverse beam emittance. Here we report on a newly developed MATLAB based GUI program used for transverse emittance measurements using the multi-slit technique. This program combines the image acquisition and post-processing tools for determining the transverse phase space parameters with uncertainties. An integral part of accelerator research is a measurement of the beam phase space. Measurements of the transverse phase space can be accomplished by a variety of methods including multiple screens separated by drift spaces, or by sampling phase space via pepper pots or slits. In any case, the measurement of the phase space parameters, in particular the emittance, can be drastically simplified and sped up by automating the measurement in an intuitive fashion utilizing a graphical interface. At the A0 Photoinjector (A0PI), the control system is DOOCS, which originated at DESY. In addition, there is a library for interfacing to MATLAB, a graphically capable numerical analysis package sold by The Mathworks. It is this graphical package which was chosen as the basis for a graphical phase space measurement system due to its combination of analysis and display capabilities.

  16. Efferent detoxification methods and evaluation of the intensive therapy efficacy in children with bacterial toxemia

    Directory of Open Access Journals (Sweden)

    M. Yu. Kurochkin

    2015-02-01

    Full Text Available The main problem of severe bacterial infections intensive therapy in children is toxemia, disorder of hemodynamic and oxygen transport. Aim. The aim of the work was to study the features of hemodynamics, oxygen transport, the level of toxemia during bacterial intoxication treatment in children, including discrete plasmapheresis. Methods and results. The study included 28 children with severe bacterial infections. We found that the inclusion of efferent methods of intensive care, such as a discrete plasmapheresis, helped to reduce circulation hyperdynamia and restore a balanced mode of delivery and oxygen consumption within 24 hours after the plasmapheresis session. Conclusion. Reduction of toxemia was noted after plasmapresis, which was confirmed by a significant decreasing in the toxicity markers level – middle molecules in the blood and leukocyte index of intoxication.

  17. Beam angle optimization for intensity-modulated radiation therapy using a guided pattern search method

    International Nuclear Information System (INIS)

    Rocha, Humberto; Dias, Joana M; Ferreira, Brígida C; Lopes, Maria C

    2013-01-01

    Generally, the inverse planning of radiation therapy consists mainly of the fluence optimization. The beam angle optimization (BAO) in intensity-modulated radiation therapy (IMRT) consists of selecting appropriate radiation incidence directions and may influence the quality of the IMRT plans, both to enhance better organ sparing and to improve tumor coverage. However, in clinical practice, most of the time, beam directions continue to be manually selected by the treatment planner without objective and rigorous criteria. The goal of this paper is to introduce a novel approach that uses beam’s-eye-view dose ray tracing metrics within a pattern search method framework in the optimization of the highly non-convex BAO problem. Pattern search methods are derivative-free optimization methods that require a few function evaluations to progress and converge and have the ability to better avoid local entrapment. The pattern search method framework is composed of a search step and a poll step at each iteration. The poll step performs a local search in a mesh neighborhood and ensures the convergence to a local minimizer or stationary point. The search step provides the flexibility for a global search since it allows searches away from the neighborhood of the current iterate. Beam’s-eye-view dose metrics assign a score to each radiation beam direction and can be used within the pattern search framework furnishing a priori knowledge of the problem so that directions with larger dosimetric scores are tested first. A set of clinical cases of head-and-neck tumors treated at the Portuguese Institute of Oncology of Coimbra is used to discuss the potential of this approach in the optimization of the BAO problem. (paper)

  18. A critical evaluation of worst case optimization methods for robust intensity-modulated proton therapy planning

    International Nuclear Information System (INIS)

    Fredriksson, Albin; Bokrantz, Rasmus

    2014-01-01

    Purpose: To critically evaluate and compare three worst case optimization methods that have been previously employed to generate intensity-modulated proton therapy treatment plans that are robust against systematic errors. The goal of the evaluation is to identify circumstances when the methods behave differently and to describe the mechanism behind the differences when they occur. Methods: The worst case methods optimize plans to perform as well as possible under the worst case scenario that can physically occur (composite worst case), the combination of the worst case scenarios for each objective constituent considered independently (objectivewise worst case), and the combination of the worst case scenarios for each voxel considered independently (voxelwise worst case). These three methods were assessed with respect to treatment planning for prostate under systematic setup uncertainty. An equivalence with probabilistic optimization was used to identify the scenarios that determine the outcome of the optimization. Results: If the conflict between target coverage and normal tissue sparing is small and no dose-volume histogram (DVH) constraints are present, then all three methods yield robust plans. Otherwise, they all have their shortcomings: Composite worst case led to unnecessarily low plan quality in boundary scenarios that were less difficult than the worst case ones. Objectivewise worst case generally led to nonrobust plans. Voxelwise worst case led to overly conservative plans with respect to DVH constraints, which resulted in excessive dose to normal tissue, and less sharp dose fall-off than the other two methods. Conclusions: The three worst case methods have clearly different behaviors. These behaviors can be understood from which scenarios that are active in the optimization. No particular method is superior to the others under all circumstances: composite worst case is suitable if the conflicts are not very severe or there are DVH constraints whereas

  19. High efficiency and stable white OLED using a single emitter

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jian [Arizona State Univ., Tempe, AZ (United States). School of Mechanical, Aerospace, Chemical and Materials Engineering

    2016-01-18

    The ultimate objective of this project was to demonstrate an efficient and stable white OLED using a single emitter on a planar glass substrate. The focus of the project is on the development of efficient and stable square planar phosphorescent emitters and evaluation of such class of materials in the device settings. Key challenges included improving the emission efficiency of molecular dopants and excimers, controlling emission color of emitters and their excimers, and improving optical and electrical stability of emissive dopants. At the end of this research program, the PI has made enough progress to demonstrate the potential of excimer-based white OLED as a cost-effective solution for WOLED panel in the solid state lighting applications.

  20. A polarization-insensitive plasmonic photoconductive terahertz emitter

    KAUST Repository

    Li, Xurong

    2017-11-16

    We present a polarization-insensitive plasmonic photoconductive terahertz emitter that uses a two-dimensional array of nanoscale cross-shaped apertures as the plasmonic contact electrodes. The geometry of the cross-shaped apertures is set to maximize optical pump absorption in close proximity to the contact electrodes. The two-dimensional symmetry of the cross-shaped apertures offers a polarization-insensitive interaction between the plasmonic contact electrodes and optical pump beam. We experimentally demonstrate a polarization-insensitive terahertz radiation from the presented emitter in response to a femtosecond optical pump beam and similar terahertz radiation powers compared to previously demonstrated polarization-sensitive photoconductive emitters with plasmonic contact electrode gratings at the optimum optical pump polarization.

  1. Emittance growth in the DARHT Axis-II Downstream Transport

    Energy Technology Data Exchange (ETDEWEB)

    Ekdahl, Jr., Carl August [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Schulze, Martin E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-04-14

    Using a particle-in-cell (PIC) code, we investigated the possibilities for emittance growth through the quadrupole magnets of the system used to transport the high-current electron beam from an induction accelerator to the bremsstrahlung converter target used for flash radiography. We found that even highly mismatched beams exhibited little emittance growth (< 6%), which we attribute to softening of their initial hard edge current distributions. We also used this PIC code to evaluate the accuracy of emittance measurements using a solenoid focal scan following the quadrupole magnets. If the beam is round after the solenoids, the simulations indicate that the measurement is highly accurate, but it is substantially inaccurate for elliptical beams

  2. Low Emittance Tuning Studies for SuperB

    Energy Technology Data Exchange (ETDEWEB)

    Liuzzo, Simone; /INFN, Pisa; Biagini, Maria; /INFN, Rome; Raimondi, Pantaleo; /INFN, Rome; Donald, Martin; /SLAC

    2012-07-06

    SuperB[1] is an international project for an asymmetric 2 rings collider at the B mesons cm energy to be built in the Rome area in Italy. The two rings will have very small beam sizes at the Interaction Point and very small emittances, similar to the Linear Collider Damping Rings ones. In particular, the ultra low vertical emittances, 7 pm in the LER and 4 pm in the HER, need a careful study of the misalignment errors effects on the machine performances. Studies on the closed orbit, vertical dispersion and coupling corrections have been carried out in order to specify the maximum allowed errors and to provide a procedure for emittance tuning. A new tool which combines MADX and Matlab routines has been developed, allowing for both corrections and tuning. Results of these studies are presented.

  3. Ion concentration in micro and nanoscale electrospray emitters.

    Science.gov (United States)

    Yuill, Elizabeth M; Baker, Lane A

    2018-06-01

    Solution-phase ion transport during electrospray has been characterized for nanopipettes, or glass capillaries pulled to nanoscale tip dimensions, and micron-sized electrospray ionization emitters. Direct visualization of charged fluorophores during the electrospray process is used to evaluate impacts of emitter size, ionic strength, analyte size, and pressure-driven flow on heterogeneous ion transport during electrospray. Mass spectrometric measurements of positively- and negatively-charged proteins were taken for micron-sized and nanopipette emitters under low ionic strength conditions to further illustrate a discrepancy in solution-driven transport of charged analytes. A fundamental understanding of analyte electromigration during electrospray, which is not always considered, is expected to provide control over selective analyte depletion and enrichment, and can be harnessed for sample cleanup. Graphical abstract Fluorescence micrographs of ion migration in nanoscale pipettes while solution is electrosprayed.

  4. Emittance measurement for high-brightness electron guns

    International Nuclear Information System (INIS)

    Kobayashi, H.; Kurihara, T.; Sato, I.; Asami, A.; Yamazaki, Y.; Otani, S.; Ishizawa, Y.

    1992-01-01

    An emittance measurement system based on a high-precision pepper-pot technique has been developed for electron guns with low emittance of around πmm-mrad. Electron guns with a 1 mmφ cathode, the material of which is impregnated tungsten or single-crystal lanthanum hexaboride (La 1-x Ce x )B 6 , have been developed. The performance has been evaluated by putting stress on cathode roughness, which gives rise to an angular divergence, according to the precise emittance measurement system. A new type of cathode holder, which is a modified version of the so called Vogel type, was developed and the beam uniformity has been improved. (Author) 5 figs., tab., 9 refs

  5. Transverse and longitudinal emittance measurements in the ELSA linac

    International Nuclear Information System (INIS)

    Loulergue, A.; Dowell, D.H.; Joly, S.; De Brion, J.P.; Haouat, G.; Schumann, F.

    1997-01-01

    The ELSA RF linac photoinjector has been designed to deliver high-brightness electron beams. The present paper deals with the transverse and longitudinal emittance measurements, at different locations along the ELSA beam line, and the analysis of their variations as a function of the photoinjector parameters : magnetic field generated by the anode focusing lens, bunch charge and pulse duration. While transverse emittance has been already studied in other similar installations, there has been little study of the electron beam longitudinal dynamics. Experimental results are presented and compared to simulation-code expectations. For 2.0 nC, 85 A electron bunches, a normalized rms emittance of 2 π mm mrad and a brightness of 4.5 x 10 13 A/(π m rad) 2 at the linac exit have been measured as well as less than 10 keV rms energy spread (or less than 0.1% at 16.5 MeV). (orig.)

  6. RF emittance in a low energy electron linear accelerator

    Science.gov (United States)

    Sanaye Hajari, Sh.; Haghtalab, S.; Shaker, H.; Kelisani, M. Dayyani

    2018-04-01

    Transverse beam dynamics of an 8 MeV low current (10 mA) S-band traveling wave electron linear accelerator has been studied and optimized. The main issue is to limit the beam emittance, mainly induced by the transverse RF forces. The linac is being constructed at Institute for Research in Fundamental Science (IPM), Tehran Iran Labeled as Iran's First Linac, nearly all components of this accelerator are designed and constructed within the country. This paper discusses the RF coupler induced field asymmetry and the corresponding emittance at different focusing levels, introduces a detailed beam dynamics design of a solenoid focusing channel aiming to reduce the emittance growth and studies the solenoid misalignment tolerances. In addition it has been demonstrated that a prebuncher cavity with appropriate parameters can help improving the beam quality in the transverse plane.

  7. DC-SC Photoinjector with Low Emittance at Peking University

    CERN Document Server

    Xiang Rong; Hao, J; Huang, Senlin; Lu Xiang Yang; Quan, Shengwen; Zhang, Baocheng; Zhao, Kui

    2005-01-01

    High average power Free Electron Lasers require the high quality electron beams with the low emittance and the sub-picosecond bunches. The design of DC-SC photoinjector, directly combining a DC photoinjector with an SRF cavity, can produce high average current beam with moderate bunch charge and high duty factor. Because of the DC gun, the emittance increases quickly at the beginning, so a carefully design is needed to control that. In this paper, the simulation of an upgraded design has been done to lower the normalized emittance below 1.5mm·mrad. The photoinjector consists of a DC gap and a 2+1/2-cell SRF cavity, and it is designed to produce 4.2 MeV electron beams at 100pC bunch charge and 81.25MHz repetition rate (8 mA average current).

  8. Laser Process for Selective Emitter Silicon Solar Cells

    Directory of Open Access Journals (Sweden)

    G. Poulain

    2012-01-01

    Full Text Available Selective emitter solar cells can provide a significant increase in conversion efficiency. However current approaches need many technological steps and alignment procedures. This paper reports on a preliminary attempt to reduce the number of processing steps and therefore the cost of selective emitter cells. In the developed procedure, a phosphorous glass covered with silicon nitride acts as the doping source. A laser is used to open locally the antireflection coating and at the same time achieve local phosphorus diffusion. In this process the standard chemical etching of the phosphorous glass is avoided. Sheet resistance variation from 100 Ω/sq to 40 Ω/sq is demonstrated with a nanosecond UV laser. Numerical simulation of the laser-matter interaction is discussed to understand the dopant diffusion efficiency. Preliminary solar cells results show a 0.5% improvement compared with a homogeneous emitter structure.

  9. Model of metastatic growth valuable for radionuclide therapy

    International Nuclear Information System (INIS)

    Bernhardt, Peter; Ahlman, Haakan; Forssell-Aronsson, Eva

    2003-01-01

    The aim was to make a Monte Carlo simulation approach to estimate the distribution of tumor sizes and to study the curative potential of three candidate radionuclides for radionuclide therapy: the high-energy electron emitter 90 Y, the medium-energy electron emitter 177 Lu and the low-energy electron emitter 103m Rh. A patient with hepatocellular carcinoma with recently published serial CT data on tumor growth in the liver was used. From these data the growth of the primary tumor, and the metastatis formation rate, were estimated. Assuming the same tumor growth of the primary and all metastases and the same metastatis formation rate from both primary and metastases the metastatic size distribution was simulated for various time points. Tumor cure of the metastatic size distribution was simulated for uniform activity distribution of three radionuclides; the high-energy electron emitter 90 Y, the mean-energy electron emitter 177 Lu and the low-energy electron emitter 103m Rh. The simulation of a tumor cure was performed for various time points and tumor-to-normal tissue activity concentrations, TNC. It was demonstrated that it is important to start therapy as early as possible after diagnosis. It was of crucial importance to use an optimal radionuclide for therapy. These simulations demonstrated that 90 Y was not suitable for systemic radionuclide therapy, due to the low absorbed fraction of the emitted electrons in small tumors ( 103m Rh was slightly better than 177 Lu. For high TNC values low-energy electron emitters, e.g., 103m Rh was the best choice for tumor cure. However, the short half-life of 103m Rh (56 min) might not be optimal for therapy. Therefore, other low-energy electron emitters, or alpha emitters, should be considered for systemic targeted therapy

  10. MRI definition of target volumes using fuzzy logic method for three-dimensional conformal radiation therapy

    International Nuclear Information System (INIS)

    Caudrelier, Jean-Michel; Vial, Stephane; Gibon, David; Kulik, Carine; Fournier, Charles; Castelain, Bernard; Coche-Dequeant, Bernard; Rousseau, Jean

    2003-01-01

    Purpose: Three-dimensional (3D) volume determination is one of the most important problems in conformal radiation therapy. Techniques of volume determination from tomographic medical imaging are usually based on two-dimensional (2D) contour definition with the result dependent on the segmentation method used, as well as on the user's manual procedure. The goal of this work is to describe and evaluate a new method that reduces the inaccuracies generally observed in the 2D contour definition and 3D volume reconstruction process. Methods and Materials: This new method has been developed by integrating the fuzziness in the 3D volume definition. It first defines semiautomatically a minimal 2D contour on each slice that definitely contains the volume and a maximal 2D contour that definitely does not contain the volume. The fuzziness region in between is processed using possibility functions in possibility theory. A volume of voxels, including the membership degree to the target volume, is then created on each slice axis, taking into account the slice position and slice profile. A resulting fuzzy volume is obtained after data fusion between multiorientation slices. Different studies have been designed to evaluate and compare this new method of target volume reconstruction and a classical reconstruction method. First, target definition accuracy and robustness were studied on phantom targets. Second, intra- and interobserver variations were studied on radiosurgery clinical cases. Results: The absolute volume errors are less than or equal to 1.5% for phantom volumes calculated by the fuzzy logic method, whereas the values obtained with the classical method are much larger than the actual volumes (absolute volume errors up to 72%). With increasing MRI slice thickness (1 mm to 8 mm), the phantom volumes calculated by the classical method are increasing exponentially with a maximum absolute error up to 300%. In contrast, the absolute volume errors are less than 12% for phantom

  11. Beam emittance reduction during operation of Indus-2

    Energy Technology Data Exchange (ETDEWEB)

    Fakhri, Ali Akbar, E-mail: fakhri@rrcat.gov.in; Kant, Pradeep; Ghodke, A. D.; Singh, Gurnam [Raja Ramanna Centre for Advanced Technology, Indore 452 013 (India)

    2015-11-15

    Indus-2 storage ring is a 2.5 GeV third generation synchrotron radiation source. This source was commissioned using a moderate optics. Beam injection was accomplished using an off momentum electron beam to avoid difficulties faced in storage of beam at 550 MeV. The injection procedure and relevant beam dynamical studies are discussed. The switch over from the moderate optics to low emittance optics is done at 2.5 GeV after storing the electron beam. The procedure evolved to reduce the beam emittance and its implementation during the operation is discussed.

  12. Nanodiamonds with photostable, sub-gigahertz linewidth quantum emitters

    Directory of Open Access Journals (Sweden)

    Toan Trong Tran

    2017-11-01

    Full Text Available Single-photon emitters with narrow linewidths are highly sought after for applications in quantum information processing and quantum communications. In this letter, we report on a bright, highly polarized near infrared single photon emitter embedded in diamond nanocrystals with a narrow, sub-GHz optical linewidth at 10 K. The observed zero-phonon line at ∼780 nm is optically stable under low power excitation and blue shifts as the excitation power increases. Our results highlight the prospect for using new near infrared color centers in nanodiamonds for quantum applications.

  13. Nanodiamonds with photostable, sub-gigahertz linewidth quantum emitters

    Science.gov (United States)

    Tran, Toan Trong; Kianinia, Mehran; Bray, Kerem; Kim, Sejeong; Xu, Zai-Quan; Gentle, Angus; Sontheimer, Bernd; Bradac, Carlo; Aharonovich, Igor

    2017-11-01

    Single-photon emitters with narrow linewidths are highly sought after for applications in quantum information processing and quantum communications. In this letter, we report on a bright, highly polarized near infrared single photon emitter embedded in diamond nanocrystals with a narrow, sub-GHz optical linewidth at 10 K. The observed zero-phonon line at ˜780 nm is optically stable under low power excitation and blue shifts as the excitation power increases. Our results highlight the prospect for using new near infrared color centers in nanodiamonds for quantum applications.

  14. Epitaxial Growth of Germanium on Silicon for Light Emitters

    Directory of Open Access Journals (Sweden)

    Chengzhao Chen

    2012-01-01

    Full Text Available This paper describes the role of Ge as an enabler for light emitters on a Si platform. In spite of the large lattice mismatch of ~4.2% between Ge and Si, high-quality Ge layers can be epitaxially grown on Si by ultrahigh-vacuum chemical vapor deposition. Applications of the Ge layers to near-infrared light emitters with various structures are reviewed, including the tensile-strained Ge epilayer, the Ge epilayer with a delta-doping SiGe layer, and the Ge/SiGe multiple quantum wells on Si. The fundamentals of photoluminescence physics in the different Ge structures are discussed briefly.

  15. Spectrum of classes of point emitters of electromagnetic wave fields.

    Science.gov (United States)

    Castañeda, Román

    2016-09-01

    The spectrum of classes of point emitters has been introduced as a numerical tool suitable for the design, analysis, and synthesis of non-paraxial optical fields in arbitrary states of spatial coherence. In this paper, the polarization state of planar electromagnetic wave fields is included in the spectrum of classes, thus increasing its modeling capabilities. In this context, optical processing is realized as a filtering on the spectrum of classes of point emitters, performed by the complex degree of spatial coherence and the two-point correlation of polarization, which could be implemented dynamically by using programmable optical devices.

  16. Emittances Studies at the Fermilab/NICADD Photoinjector Laboratory

    CERN Document Server

    Tikhoplav, Rodion; Melissinos, A C; Regis-Guy Piot, Philippe

    2005-01-01

    The Fermilab/NICADD photoinjector incorporates an L-band rf-gun capable of generating 1-10 nC bunches. The bunches are then accelerated to 16 MeV with a TESLA superconducting cavity. In the present paper we present parametric studies of transverse emittances and energy spread for a various operating points of the electron source (RF-gun E-field, laser length and spot size, and solenoid settings). We especially study the impact, on transverse emittance, of Gaussian and Plateau temporal distribution of the photocathode drive-laser.

  17. Mirrorless lasing from light emitters in percolating clusters

    Science.gov (United States)

    Burlak, Gennadiy; Rubo, Y. G.

    2015-07-01

    We describe the lasing effect in the three-dimensional percolation system, where the percolating cluster is filled by active media composed by light emitters excited noncoherently. We show that, due to the presence of a topologically nontrivial photonic structure, the stimulated emission is modified with respect to both conventional and random lasers. The time dynamics and spectra of the lasing output are studied numerically with finite-difference time-domain approach. The Fermat principle and Monte Carlo approach are applied to characterize the optimal optical path and interconnection between the radiating emitters. The spatial structure of the laser mode is found by a long-time FDTD simulation.

  18. Model of emittance growth in a self-pinched beam

    International Nuclear Information System (INIS)

    Lee, E.P.; Yu, S.S.

    1979-01-01

    A semi-phenomenological formula is proposed for the change of emittance of a self-pinched beam which is not matched to its equilibrium radius. Near equilibrium this formula, coupled with an envelope equation, yields the damped sausage oscillations observed in simulation and experiments. For a beam which is injected cold (no transverse velocity spread), the formula coincides with the analytically calculated initial growth of emittance. The basic theory is developed here and used to compute the linear damping rate for several current profiles. The resultant non-linear increase in equilibrium quantities is also calculated in lowest order of the degree of mismatch

  19. Automation and uncertainty analysis of a method for in-vivo range verification in particle therapy.

    Science.gov (United States)

    Frey, K; Unholtz, D; Bauer, J; Debus, J; Min, C H; Bortfeld, T; Paganetti, H; Parodi, K

    2014-10-07

    We introduce the automation of the range difference calculation deduced from particle-irradiation induced β(+)-activity distributions with the so-called most-likely-shift approach, and evaluate its reliability via the monitoring of algorithm- and patient-specific uncertainty factors. The calculation of the range deviation is based on the minimization of the absolute profile differences in the distal part of two activity depth profiles shifted against each other. Depending on the workflow of positron emission tomography (PET)-based range verification, the two profiles under evaluation can correspond to measured and simulated distributions, or only measured data from different treatment sessions. In comparison to previous work, the proposed approach includes an automated identification of the distal region of interest for each pair of PET depth profiles and under consideration of the planned dose distribution, resulting in the optimal shift distance. Moreover, it introduces an estimate of uncertainty associated to the identified shift, which is then used as weighting factor to 'red flag' problematic large range differences. Furthermore, additional patient-specific uncertainty factors are calculated using available computed tomography (CT) data to support the range analysis. The performance of the new method for in-vivo treatment verification in the clinical routine is investigated with in-room PET images for proton therapy as well as with offline PET images for proton and carbon ion therapy. The comparison between measured PET activity distributions and predictions obtained by Monte Carlo simulations or measurements from previous treatment fractions is performed. For this purpose, a total of 15 patient datasets were analyzed, which were acquired at Massachusetts General Hospital and Heidelberg Ion-Beam Therapy Center with in-room PET and offline PET/CT scanners, respectively. Calculated range differences between the compared activity distributions are reported in a

  20. Real-time dose compensation methods for scanned ion beam therapy of moving tumors

    International Nuclear Information System (INIS)

    Luechtenborg, Robert

    2012-01-01

    Scanned ion beam therapy provides highly tumor-conformal treatments. So far, only tumors showing no considerable motion during therapy have been treated as tumor motion and dynamic beam delivery interfere, causing dose deteriorations. One proposed technique to mitigate these deteriorations is beam tracking (BT), which adapts the beam position to the moving tumor. Despite application of BT, dose deviations can occur in the case of non-translational motion. In this work, real-time dose compensation combined with beam tracking (RDBT) has been implemented into the control system to compensate these dose changes by adaptation of nominal particle numbers during irradiation. Compared to BT, significantly reduced dose deviations were measured using RDBT. Treatment planning studies for lung cancer patients including the increased biological effectiveness of ions revealed a significantly reduced over-dose level (3/5 patients) as well as significantly improved dose homogeneity (4/5 patients) for RDBT. Based on these findings, real-time dose compensated re-scanning (RDRS) has been proposed that potentially supersedes the technically complex fast energy adaptation necessary for BT and RDBT. Significantly improved conformity compared to re-scanning, i.e., averaging of dose deviations by repeated irradiation, was measured in film irradiations. Simulations comparing RDRS to BT revealed reduced under- and overdoses of the former method.

  1. Sensitization of the analytical methods for photoneutron calculations to the wall concrete composition in radiation therapy

    International Nuclear Information System (INIS)

    Ghiasi, Hosein; Mesbahi, Asghar

    2012-01-01

    The effect of wall material on photoneutron production in radiation therapy rooms was studied using Monte Carlo (MC) simulations. An analytical formula was proposed to take into account the concrete composition in photoneutron dose calculations. Using the MCNPX MC code, the 18 MV photon beam of the Varian Clinac 2100 and a typical treatment room with concrete compositions according to report No. 144 of National Council of Radiation Protection (NCRP) were simulated. Number of room produced photoneutrons per Gray of X-ray at the isocenter was determined for different types of concrete and named as “Q W ”. This new factor was inserted in the used formula for photoneutron fluence calculations at the inner entrance of maze. The photoneutron fluence was calculated using new proposed formula at the inner entrance of maze for all studied concretes. The difference between conventional and proposed equations varied from 11% to 46% for studied concretes. It was found that room produced photoneutrons could be significant for high density concretes. Additionally, applying the new proposed formula can consider the effect of wall material composition on the photoneutron production in high energy radiation therapy rooms. Further studies to confirm the accuracy of newly developed method is recommended.

  2. Therapy evaluation and diagnostic accuracy in neuroendocrine tumours: assessment of radiological methods

    International Nuclear Information System (INIS)

    Elvin, A.

    1993-01-01

    The diagnostic accuracy of ultrasonically guided biopsy-gun biopsies was assessed in a group of 47 patients with suspected pancreatic carcinoma. A correct diagnosis was obtained in 44 of the 47 patients (94%). Biopsy-gun biopsy of the pancreas is considered a useful, reliable and non-traumatic method for the diagnosis of pancreatic malignancy. Twenty-five patients with known neuroendocrine tumour disease were biopsied with 1.2 mm and 0.9 mm biopsy-gun needles. The influence of treatment-related fibrosis was also evaluated. The overall diagnostic accuracy with the 0.9 mm needle was 69% as compared to 92% with the 1.2 mm needle. In order to assess the diagnostic accuracy rate for radiologists with different experience of biopsy procedures 175 cases of renal biopsy-gun biopsies were evaluated. No statistical significant difference was found between the different operators. The role of duplex Doppler ultrasound in monitoring interferon treatment-related changes in carcinoid metastases was evaluated. It present duplex Doppler ultrasound does not seem to play a role in the evaluation of tumour therapy in carcinoid patients. Therapy response evaluation was performed with MR imaging in a group of 17 patients with neuroendocrine liver metastases. A significant difference was found between patients responding to and patients with failure of treatment in terms of tumour T1, contrast enhancement and signal intensity ratio. This indicates that MR investigation may be used in therapy monitoring of patients with neuroendocrine metastases. The neuroendocrine-differentiated colonic carcinoma cell line (LCC-18) was transplanted to 29 mice to establish a tumour/animal model that would allow the monitoring of changes with MR imaging induced by interferon therapy and to evaluate whether the therapeutic response could be modulated by different interferon dosages. Interferon does not seem to have any prolonged anti-proliferative effect on the LCC-18 tumour cell line when transplanted to

  3. From traditional cognitive-behavioural therapy to acceptance and commitment therapy for chronic pain: a mixed-methods study of staff experiences of change.

    Science.gov (United States)

    Barker, Estelle; McCracken, Lance M

    2014-08-01

    Health care organizations, both large and small, frequently undergo processes of change. In fact, if health care organizations are to improve over time, they must change; this includes pain services. The purpose of the present study was to examine a process of change in treatment model within a specialty interdisciplinary pain service in the UK. This change entailed a switch from traditional cognitive-behavioural therapy to a form of cognitive-behavioural therapy called acceptance and commitment therapy. An anonymous online survey, including qualitative and quantitative components, was carried out approximately 15 months after the initial introduction of the new treatment model and methods. Fourteen out of 16 current clinical staff responded to the survey. Three themes emerged in qualitative analyses: positive engagement in change; uncertainty and discomfort; and group cohesion versus discord. Quantitative results from closed questions showed a pattern of uncertainty about the superiority of one model over the other, combined with more positive views on progress reflected, and the experience of personal benefits, from adopting the new model. The psychological flexibility model, the model behind acceptance and commitment therapy, may clarify both processes in patient behaviour and processes of staff experience and skilful treatment delivery. This integration of processes on both sides of treatment delivery may be a strength of acceptance and commitment therapy.

  4. Boundary conditions on the plasma emitter surface in the presence of a particle counter flow: I. Ion emitter

    Energy Technology Data Exchange (ETDEWEB)

    Astrelin, V. T., E-mail: V.T.Astrelin@inp.nsk.su; Kotelnikov, I. A. [Russian Academy of Sciences, Budker Institute of Nuclear Physics, Siberian Branch (Russian Federation)

    2017-02-15

    Emission of positively charged ions from a plasma emitter irradiated by a counterpropagating electron beam is studied theoretically. A bipolar diode with a plasma emitter in which the ion temperature is lower than the electron temperature and the counter electron flow is extracted from the ion collector is calculated in the one-dimensional model. An analog of Bohm’s criterion for ion emission in the presence of a counterpropagating electron beam is derived. The limiting density of the counterpropagating beam in a bipolar diode operating in the space-charge-limited-emission regime is calculated. The full set of boundary conditions on the plasma emitter surface that are required for operation of the high-current optics module in numerical codes used to simulate charged particle sources is formulated.

  5. Energy measurement and longitudinal beam emittance reconstruction in L4T line

    CERN Document Server

    Meng, C; Garoby, R; Lallement, JB; Lombardi, A; Tang, J Y; Yarmohammadi Satri, M; CERN. Geneva. ATS Department

    2013-01-01

    LINAC4 is a new linear accelerator for H- ion which will replace proton Linac2 as injector for the CERN proton accelerator complex. LINAC4 accelerates H− ions from 45 keV to 160 MeV in a sequence of normal conducting structures. Then, H- ions with a kinetic energy of 160 MeV will be sent to the PS Booster. This note describes two energy measurement methods and a improved method that will be used for longitudinal emittance reconstruction with space charge by multi-particle tracking code and the expected results.

  6. Teaching Theory in Occupational Therapy Using a Cooperative Learning: A Mixed-Methods Study.

    Science.gov (United States)

    Howe, Tsu-Hsin; Sheu, Ching-Fan; Hinojosa, Jim

    2018-01-01

    Cooperative learning provides an important vehicle for active learning, as knowledge is socially constructed through interaction with others. This study investigated the effect of cooperative learning on occupational therapy (OT) theory knowledge attainment in professional-level OT students in a classroom environment. Using a pre- and post-test group design, 24 first-year, entry-level OT students participated while taking a theory course in their second semester of the program. Cooperative learning methods were implemented via in-class group assignments. The students were asked to complete two questionnaires regarding their attitudes toward group environments and their perception toward group learning before and after the semester. MANCOVA was used to examine changes in attitudes and perceived learning among groups. Students' summary sheets for each in-class assignment and course evaluations were collected for content analysis. Results indicated significant changes in students' attitude toward working in small groups regardless of their prior group experience.

  7. A region-based segmentation method for ultrasound images in HIFU therapy

    International Nuclear Information System (INIS)

    Zhang, Dong; Liu, Yu; Yang, Yan; Xu, Menglong; Yan, Yu; Qin, Qianqing

    2016-01-01

    Purpose: Precisely and efficiently locating a tumor with less manual intervention in ultrasound-guided high-intensity focused ultrasound (HIFU) therapy is one of the keys to guaranteeing the therapeutic result and improving the efficiency of the treatment. The segmentation of ultrasound images has always been difficult due to the influences of speckle, acoustic shadows, and signal attenuation as well as the variety of tumor appearance. The quality of HIFU guidance images is even poorer than that of conventional diagnostic ultrasound images because the ultrasonic probe used for HIFU guidance usually obtains images without making contact with the patient’s body. Therefore, the segmentation becomes more difficult. To solve the segmentation problem of ultrasound guidance image in the treatment planning procedure for HIFU therapy, a novel region-based segmentation method for uterine fibroids in HIFU guidance images is proposed. Methods: Tumor partitioning in HIFU guidance image without manual intervention is achieved by a region-based split-and-merge framework. A new iterative multiple region growing algorithm is proposed to first split the image into homogenous regions (superpixels). The features extracted within these homogenous regions will be more stable than those extracted within the conventional neighborhood of a pixel. The split regions are then merged by a superpixel-based adaptive spectral clustering algorithm. To ensure the superpixels that belong to the same tumor can be clustered together in the merging process, a particular construction strategy for the similarity matrix is adopted for the spectral clustering, and the similarity matrix is constructed by taking advantage of a combination of specifically selected first-order and second-order texture features computed from the gray levels and the gray level co-occurrence matrixes, respectively. The tumor region is picked out automatically from the background regions by an algorithm according to a priori

  8. Methods for extracting dose response curves from radiation therapy data. I. A unified approach

    International Nuclear Information System (INIS)

    Herring, D.F.

    1980-01-01

    This paper discusses an approach to fitting models to radiation therapy data in order to extract dose response curves for tumor local control and normal tissue damage. The approach is based on the method of maximum likelihood and is illustrated by several examples. A general linear logistic equation which leads to the Ellis nominal standard dose (NSD) equation is discussed; the fit of this equation to experimental data for mouse foot skin reactions produced by fractionated irradiation is described. A logistic equation based on the concept that normal tissue reactions are associated with the surviving fraction of cells is also discussed, and the fit of this equation to the same set of mouse foot skin reaction data is also described. These two examples illustrate the importance of choosing a model based on underlying mechanisms when one seeks to attach biological significance to a model's parameters

  9. A region-based segmentation method for ultrasound images in HIFU therapy

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Dong, E-mail: dongz@whu.edu.cn; Liu, Yu; Yang, Yan; Xu, Menglong; Yan, Yu [School of Physics and Technology, Wuhan University, Wuhan 430072 (China); Qin, Qianqing [State Key Laboratory of Information Engineering in Surveying, Mapping and Remote Sensing, Wuhan University, Wuhan 430072 (China)

    2016-06-15

    Purpose: Precisely and efficiently locating a tumor with less manual intervention in ultrasound-guided high-intensity focused ultrasound (HIFU) therapy is one of the keys to guaranteeing the therapeutic result and improving the efficiency of the treatment. The segmentation of ultrasound images has always been difficult due to the influences of speckle, acoustic shadows, and signal attenuation as well as the variety of tumor appearance. The quality of HIFU guidance images is even poorer than that of conventional diagnostic ultrasound images because the ultrasonic probe used for HIFU guidance usually obtains images without making contact with the patient’s body. Therefore, the segmentation becomes more difficult. To solve the segmentation problem of ultrasound guidance image in the treatment planning procedure for HIFU therapy, a novel region-based segmentation method for uterine fibroids in HIFU guidance images is proposed. Methods: Tumor partitioning in HIFU guidance image without manual intervention is achieved by a region-based split-and-merge framework. A new iterative multiple region growing algorithm is proposed to first split the image into homogenous regions (superpixels). The features extracted within these homogenous regions will be more stable than those extracted within the conventional neighborhood of a pixel. The split regions are then merged by a superpixel-based adaptive spectral clustering algorithm. To ensure the superpixels that belong to the same tumor can be clustered together in the merging process, a particular construction strategy for the similarity matrix is adopted for the spectral clustering, and the similarity matrix is constructed by taking advantage of a combination of specifically selected first-order and second-order texture features computed from the gray levels and the gray level co-occurrence matrixes, respectively. The tumor region is picked out automatically from the background regions by an algorithm according to a priori

  10. A method of segment weight optimization for intensity modulated radiation therapy

    International Nuclear Information System (INIS)

    Pei Xi; Cao Ruifen; Jing Jia; Cheng Mengyun; Zheng Huaqing; Li Jia; Huang Shanqing; Li Gui; Song Gang; Wang Weihua; Wu Yican; FDS Team

    2011-01-01

    The error caused by leaf sequencing often leads to planning of Intensity-Modulated Radiation Therapy (IMRT) arrange system couldn't meet clinical demand. The optimization approach in this paper can reduce this error and improve efficiency of plan-making effectively. Conjugate Gradient algorithm was used to optimize segment weight and readjust segment shape, which could minimize the error anterior-posterior leaf sequencing eventually. Frequent clinical cases were tasted by precise radiotherapy system, and then compared Dose-Volume histogram between target area and organ at risk as well as isodose line in computed tomography (CT) film, we found that the effect was improved significantly after optimizing segment weight. Segment weight optimizing approach based on Conjugate Gradient method can make treatment planning meet clinical request more efficiently, so that has extensive application perspective. (authors)

  11. Individual radiation therapy patient whole-body phantoms for peripheral dose evaluations: method and specific software

    International Nuclear Information System (INIS)

    Alziar, I; Vicente, C; Giordana, G; Ben-Harrath, O; De Vathaire, F; Diallo, I; Bonniaud, G; Couanet, D; Chavaudra, J; Lefkopoulos, D; Ruaud, J B; Diaz, J C; Grandjean, P; Kafrouni, H

    2009-01-01

    This study presents a method aimed at creating radiotherapy (RT) patient-adjustable whole-body phantoms to permit retrospective and prospective peripheral dose evaluations for enhanced patient radioprotection. Our strategy involves virtual whole-body patient models (WBPM) in different RT treatment positions for both genders and for different age groups. It includes a software tool designed to match the anatomy of the phantoms with the anatomy of the actual patients, based on the quality of patient data available. The procedure for adjusting a WBPM to patient morphology includes typical dimensions available in basic auxological tables for the French population. Adjustment is semi-automatic. Because of the complexity of the human anatomy, skilled personnel are required to validate changes made in the phantom anatomy. This research is part of a global project aimed at proposing appropriate methods and software tools capable of reconstituting the anatomy and dose evaluations in the entire body of RT patients in an adapted treatment planning system (TPS). The graphic user interface is that of a TPS adapted to obtain a comfortable working process. Such WBPM have been used to supplement patient therapy planning images, usually restricted to regions involved in treatment. Here we report, as an example, the case of a patient treated for prostate cancer whose therapy planning images were complemented by an anatomy model. Although present results are preliminary and our research is ongoing, they appear encouraging, since such patient-adjusted phantoms are crucial in the optimization of radiation protection of patients and for follow-up studies. (note)

  12. Individual radiation therapy patient whole-body phantoms for peripheral dose evaluations: method and specific software.

    Science.gov (United States)

    Alziar, I; Bonniaud, G; Couanet, D; Ruaud, J B; Vicente, C; Giordana, G; Ben-Harrath, O; Diaz, J C; Grandjean, P; Kafrouni, H; Chavaudra, J; Lefkopoulos, D; de Vathaire, F; Diallo, I

    2009-09-07

    This study presents a method aimed at creating radiotherapy (RT) patient-adjustable whole-body phantoms to permit retrospective and prospective peripheral dose evaluations for enhanced patient radioprotection. Our strategy involves virtual whole-body patient models (WBPM) in different RT treatment positions for both genders and for different age groups. It includes a software tool designed to match the anatomy of the phantoms with the anatomy of the actual patients, based on the quality of patient data available. The procedure for adjusting a WBPM to patient morphology includes typical dimensions available in basic auxological tables for the French population. Adjustment is semi-automatic. Because of the complexity of the human anatomy, skilled personnel are required to validate changes made in the phantom anatomy. This research is part of a global project aimed at proposing appropriate methods and software tools capable of reconstituting the anatomy and dose evaluations in the entire body of RT patients in an adapted treatment planning system (TPS). The graphic user interface is that of a TPS adapted to obtain a comfortable working process. Such WBPM have been used to supplement patient therapy planning images, usually restricted to regions involved in treatment. Here we report, as an example, the case of a patient treated for prostate cancer whose therapy planning images were complemented by an anatomy model. Although present results are preliminary and our research is ongoing, they appear encouraging, since such patient-adjusted phantoms are crucial in the optimization of radiation protection of patients and for follow-up studies.

  13. Repeated dose titration versus age-based method in electroconvulsive therapy: a pilot study.

    Science.gov (United States)

    Aten, Jan Jaap; Oudega, Mardien; van Exel, Eric; Stek, Max L; van Waarde, Jeroen A

    2015-06-01

    In electroconvulsive therapy (ECT), a dose titration method (DTM) was suggested to be more individualized and therefore more accurate than formula-based dosing methods. A repeated DTM (every sixth session and dose adjustment accordingly) was compared to an age-based method (ABM) regarding treatment characteristics, clinical outcome, and cognitive functioning after ECT. Thirty-nine unipolar depressed patients dosed using repeated DTM and 40 matched patients treated with ABM were compared. Montgomery-Åsberg Depression Rating Scale (MADRS) and Mini-Mental State Examination (MMSE) were assessed at baseline and at the end of the index course, as well as the total number of ECT sessions. Both groups were similar regarding age, sex, psychotic features, mean baseline MADRS, and median baseline MMSE. At the end of the index course, the two methods showed equal outcome (mean end MADRS, 11.6 ± 8.3 in DTM and 9.5 ± 7.6 in ABM (P = 0.26); median end MMSE, 28 (25-29) and 28 (25-29.8), respectively (P = 0.81). However, the median number of all ECT sessions differed 16 (11-22) in DTM versus 12 (10-14.8) in ABM; P = 0.02]. Using regression analysis, dosing method and age were independently associated with the total number of ECT sessions, with less sessions needed in ABM (P = 0.02) and in older patients (P = 0.001). In this comparative cohort study, ABM and DTM showed equal outcome for depression and cognition. However, the median ECT course duration in repeated DTM appeared longer. Additionally, higher age was associated with shorter ECT courses regardless of the dosing method. Further prospective studies are needed to confirm these findings.

  14. Accelerator based Production of Auger-Electron-emitting Isotopes for Radionuclide Therapy

    DEFF Research Database (Denmark)

    Thisgaard, Helge

    Sb from the enriched 119Sn target material with high radionuclidic- and chemical purity. A method that also allows efficient recovery of the 119Sn for recycling. To demonstrate the ability of producing therapeutic quantities of 119Sb and other radioisotopes for therapy with a low-energy cyclotron...... isotopes (e.g. 119Sb or 64Cu) using the PETtrace cyclotron commonly found at the larger PET-centers in the hospitals. Finally, research in a new method to measure the radiotoxicity of Auger-emitters invitro using cellular microinjection has been carried out. The purpose of this method is to be able...

  15. In ovo method for evaluating the effect of nutritional therapies on tumor development, growth and vascularization

    Directory of Open Access Journals (Sweden)

    Yves M. Dupertuis

    2015-10-01

    Full Text Available In the state of the art evaluation of nutritional therapy on tumor development, growth and vascularization requires tedious and expensive in vivo assays in which a significant number of animals undergo invasive treatments. Therefore, new alternative methods to avoid animal suffering and sacrifice are welcome. This review presents a rapid and low-cost method of experimental radio/chemotherapy in tumor xenografted chicken chorioallantoic membrane (CAM, which may contribute to implement the 3R principle (Reduce, Refine, Replace. Advantages and limitations of the CAM as an experimental model in cancer research are discussed. Improving the CAM model by using tumor spheroid grafting and positron emission and computed tomography imaging would help to overcome the drawbacks of poor tumor grafting efficiency and restrained 2-D tumor growth measurement to the CAM surface. Such a simple, reliable, reproducible and quantitative method for obtaining dose–response analysis and estimating treatment schedule (i.e. type, route, dose and timing would provide an alternative to the time-consuming and expensive evaluation step in animals before initiating clinical trials.

  16. Use of a risk assessment method to improve the safety of negative pressure wound therapy.

    Science.gov (United States)

    Lelong, Anne-Sophie; Martelli, Nicolas; Bonan, Brigitte; Prognon, Patrice; Pineau, Judith

    2014-06-01

    To conduct a risk analysis of the negative pressure wound therapy (NPWT) care process and to improve the safety of NPWT, a working group of nurses, hospital pharmacists, physicians and hospital managers performed a risk analysis for the process of NPWT care. The failure modes, effects and criticality analysis (FMECA) method was used for this analysis. Failure modes and their consequences were defined and classified as a function of their criticality to identify priority actions for improvement. By contrast to classical FMECA, the criticality index (CI) of each consequence was calculated by multiplying occurrence, severity and detection scores. We identified 13 failure modes, leading to 20 different consequences. The CI of consequences was initially 712, falling to 357 after corrective measures were implemented. The major improvements proposed included the establishment of 6-monthly training cycles for nurses, physicians and surgeons and the introduction of computerised prescription for NPWT. The FMECA method also made it possible to prioritise actions as a function of the criticality ranking of consequences and was easily understood and used by the working group. This study is, to our knowledge, the first to use the FMECA method to improve the safety of NPWT. © 2012 The Authors. International Wound Journal © 2012 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

  17. Enhanced thermaly managed packaging for III-nitride light emitters

    Science.gov (United States)

    Kudsieh, Nicolas

    In this Dissertation our work on `enhanced thermally managed packaging of high power semiconductor light sources for solid state lighting (SSL)' is presented. The motivation of this research and development is to design thermally high stable cost-efficient packaging of single and multi-chip arrays of III-nitrides wide bandgap semiconductor light sources through mathematical modeling and simulations. Major issues linked with this technology are device overheating which causes serious degradation in their illumination intensity and decrease in the lifetime. In the introduction the basics of III-nitrides WBG semiconductor light emitters are presented along with necessary thermal management of high power cingulated and multi-chip LEDs and laser diodes. This work starts at chip level followed by its extension to fully packaged lighting modules and devices. Different III-nitride structures of multi-quantum well InGaN/GaN and AlGaN/GaN based LEDs and LDs were analyzed using advanced modeling and simulation for different packaging designs and high thermal conductivity materials. Study started with basic surface mounted devices using conventional packaging strategies and was concluded with the latest thermal management of chip-on-plate (COP) method. Newly discovered high thermal conductivity materials have also been incorporated for this work. Our study also presents the new approach of 2D heat spreaders using such materials for SSL and micro LED array packaging. Most of the work has been presented in international conferences proceedings and peer review journals. Some of the latest work has also been submitted to well reputed international journals which are currently been reviewed for publication. .

  18. Magnet design for a low-emittance storage ring

    International Nuclear Information System (INIS)

    Johansson, Martin; Anderberg, Bengt; Lindgren, Lars-Johan

    2014-01-01

    The magnet design of the MAX IV 3 GeV storage ring replaces the conventional support girder + discrete magnets scheme of previous third-generation light sources with a compact integrated design having several consecutive magnet elements precision-machined out of a common solid iron block. The MAX IV 3 GeV storage ring, currently under construction, pursues the goal of low electron beam emittance by using a multi-bend achromat magnet lattice, which is realised by having several consecutive magnet elements precision-machined out of a common solid iron block, 2.3–3.4 m long. With this magnet design solution, instead of having 1320 individual magnets, the MAX IV 3 GeV storage ring is built up using 140 integrated ‘magnet block’ units, containing all these magnet elements. Major features of this magnet block design are compactness, vibration stability and that the alignment of magnet elements within each unit is given by the mechanical accuracy of the CNC machining rather than individual field measurement and adjustment. This article presents practical engineering details of implementing this magnet design solution, and mechanical + magnetic field measurement results from the magnet production series. At the time of writing (spring 2014), the production series, which is totally outsourced to industry, is roughly half way through, with mechanical/magnetic QA conforming to specifications. It is the conclusion of the authors that the MAX IV magnet block concept, which has sometimes been described as new or innovative, is from a manufacturing point of view simply a collection of known mature production methods and measurement procedures, which can be executed at fixed cost with a low level of risk

  19. A thermionic energy converter with A molybdenum alumina cermet emitter

    NARCIS (Netherlands)

    Gubbels, G.H.M.; Wolff, L.R.; Metselaar, R.; Yogi Goswami, D.

    1988-01-01

    The I-V characteristics of a thermionic converter equipped with a Mo-1w/o AI203 emitter and a Mo collector were measured. The conditions were varied over a limited range without, as well as with Cs. Work functions of Mo as well as Mo-1w/o AI203 were determined. Measurements were carried out in a

  20. Laser-assisted electron emission from gated field-emitters

    CERN Document Server

    Ishizuka, H; Yokoo, K; Mimura, H; Shimawaki, H; Hosono, A

    2002-01-01

    Enhancement of electron emission by illumination of gated field-emitters was studied using a 100 mW cw YAG laser at a wavelength of 532 nm, intensities up to 10 sup 7 W/m sup 2 and mechanically chopped with a rise time of 4 mu s. When shining an array of 640 silicon emitters, the emission current responded quickly to on-off of the laser. The increase of the emission current was proportional to the basic emission current at low gate voltages, but it was saturated at approx 3 mu A as the basic current approached 100 mu A with the increase of gate voltage. The emission increase was proportional to the square root of laser power at low gate voltages and to the laser power at elevated gate voltages. For 1- and 3-tip silicon emitters, the rise and fall of the current due to on-off of the laser showed a significant time lag. The magnitude of emission increase was independent of the position of laser spot on the emitter base and reached 2 mu A at a basic current of 5 mu A without showing signs of saturation. The mech...

  1. Calculation Of Extraction Optics For Ion System With Plazma Emitter

    CERN Document Server

    Frolov, B A

    2004-01-01

    The 2-D code for simulating of ion optics system of positive ion extraction from a plasma source is described. Example calculation of 100 kV optics for the extraction ion IHEP gun is presented. The trajectories of particles and emittance plots are resulted. The aberrations influ-ence strongly on ion optics for considered geometry.

  2. Short-lived positron emitter labeled radiotracers - present status

    International Nuclear Information System (INIS)

    Fowler, J.S.; Wolf, A.P.

    1982-01-01

    The preparation of labelled compounds is important for the application of positron emission transaxial tomography (PETT) in biomedical sciences. This paper describes problems and progress in the synthesis of short-lived positron emitter ( 11 C, 18 F, 13 N) labelled tracers for PETT. Synthesis of labelled sugars, amino acids, and neurotransmitter receptors (pimozide and spiroperidol tagged with 11 C) is discussed in particular

  3. Emittance control and RF bunch compression in the NSRRC photoinjector

    International Nuclear Information System (INIS)

    Lau, W.K.; Hung, S.B.; Lee, A.P.; Chou, C.S.; Huang, N.Y.

    2011-01-01

    The high-brightness photoinjector being constructed at the National Synchrotron Radiation Research Center is for testing new accelerator and light-source concepts. It is the so-called split photoinjector configuration in which a short solenoid magnet is used for emittance compensation. The UV-drive laser pulses are also shaped to produce uniform cylindrical bunches for further reduction of beam emittance. However, limited by the available power from our microwave power system, the nominal accelerating gradient in the S-band booster linac is set at 18 MV/m. A simulation study with PARMELA shows that the linac operating at this gradient fails to freeze the electron beam emittance at low value. A background solenoid magnetic field is applied for beam emittance control in the linac during acceleration. A satisfactory result that meets our preliminary goal has been achieved with the solenoid magnetic field strength at 0.1 T. RF bunch compression as a means to achieve the required beam brightness for high-gain free-electron laser experiments is also examined. The reduction of bunch length to a few hundred femtoseconds can be obtained.

  4. Application of positron emitters to studies on plants

    Energy Technology Data Exchange (ETDEWEB)

    Ishioka, N S; Matsuoka, H [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment; Sekine, T [and others

    1998-10-01

    A newly developed positron emitting tracer imaging system enables us to study dynamically the physiological function of plants, although this system covers, at present, a limited area in a plant. Production of the positron emitters {sup 11}C, {sup 13}N, {sup 18}F and {sup 48}V for this application, using an AVF cyclotron, is described. (author)

  5. Beam emittance of the Stony Brook Tandem-LINAC booster

    International Nuclear Information System (INIS)

    Scholldorf, A.H.

    1984-01-01

    This dissertation is primarily a study of the longitudinal and transverse beam emittance of the Stony Brook Heavy Ion Tandem LINAC Accelerator Facility, with a secondary emphasis on the beam dynamical design of two key elements of the system: a low energy double-drift buncher, and an achromatic double-90 0 LINAC injection system. A transverse emittance measuring system consisting of two translation stages controlled by stepper motors is described. Each stage carried a pair of beam defining slits mounted so that both horizontal and vertical emittances could be measured with only linear motion of the stage assembly. Beam currents were measured directly by a low-noise, high-sensitivity electrometer circuit integrated with the second slit-stage assembly. A mini-computer controlled the motors and acquired and displayed the data. Transverse emittance areas of beams of 12 C, 16 O, 32 S, and 58 Ni were measured at ion source extraction potential, after ion source acceleration, after tandem acceleration, and after LINAC acceleration. The results were analyzed in terms of source sputter-cone geometry, angle straggling in gas and foil strippers, and a variety of other factors

  6. Emittance growth due to beam-gas scattering

    International Nuclear Information System (INIS)

    Raubenheimer, T.O.

    1992-06-01

    The effect of beam-gas scattering on beam emittance is examined by deriving the beam distribution function. The distribution function is found by treating the beam-gas scattering as a filtered Poisson process and calculating the cumulants of the distribution. (author)

  7. Emittance growth in laser-driven RF electron guns

    International Nuclear Information System (INIS)

    Kim, K.J.

    1989-01-01

    A simple analysis for the evolution of the electron-beam phase space distribution in laser-driven rf guns is presented. In particular, formulas are derived for the transverse and longitudinal emittances at the exit of the gun. The results are compared and found to agree well with those from simulation. (Author). 9 refs.; 4 figs

  8. A compact electron gun using field emitter array

    International Nuclear Information System (INIS)

    Asakawa, M.R.; Ikeda, A.; Miyabe, N.; Yamaguchi, S.; Kusaba, M.; Tsunawaki, Y.

    2008-01-01

    A compact electron gun using field emitter array has been developed. With a simple triode configuration consisting of FEA, mid-electrode and anode electrode, the electron gun produces a parallel beam with a diameter of 0.5 mm. This electron gun is applicable for compact radiation sources such as Cherenkov free-electron lasers

  9. Beam aperture and emittance growth in the AGS-Booster

    International Nuclear Information System (INIS)

    Parsa, Z.

    1987-01-01

    The authors have developed analytical tools for calculating the variation of particle action, smear and emittance growth due to nonlinear elements in accelerators (with second order perturbation theory in two dimensions). The authors' results for the AGS-Booster is presented

  10. The emittance of high current heavy ion beams

    International Nuclear Information System (INIS)

    White, N.R.; Devaney, A.S.

    1989-01-01

    Ion implantation is the main application for high current heavy ion beams. Transfer ratio is defined as the ratio of the total ion current leaving the ion source to the current delivered to the endstation. This ratio is monitored and logged and its importance is explained. It is also affected by other factors, such as the isotopic and molecular composition of the total ion beam. The transfer ratio reveals the fraction of ions which are intercepted by parts of the beamline system. The effects of these ions are discussed in two categories: processing purity and reliability. In discussing the emittance of ribbon beams, the two orthogonal planes are usually considered separately. Longitudinal emittance is determined by slot length and by plasma ion temperature. It has already been revealed that the longitudinal divergence of the beams from BF3 is perhaps double that of the beam from arsenic vapour or argon, at the same total perveance from the ion source. This poses the question: why is the ion temperature higher for BF3 than for As or Ar? The transverse emittance is in practical terms dominated by the divergence. It is the most fruitful area for improvement in most real-world systems. There is an intrinsic divergence arising from initial ion energies within the plasma, and there is emittance growth that can occur as a result of aberration in the beam extraction optics. (N.K.)

  11. Porous Emitter Colloid Thruster Performance Characterization Using Optical Techniques

    Science.gov (United States)

    2013-03-01

    that the surface of the cone is equipotential . In order to include this constraint, Laplace’s Equation was used in the axisymmetric case to solve...43 ix Page 3.3 Emitter Surface Imaging...3. Taylor Cone geometry showing the opposing electric and internal surface tension stresses

  12. Auger electron emitters: Insights gained from in vitro experiments

    International Nuclear Information System (INIS)

    Makrigiorgos, G.; Adelstein, S.J.; Kassis, A.I.

    1990-01-01

    This paper outlines the evolution of the current rationale for research into the biological effects of tissue-incorporated Auger electron emitters. The first section is a brief review of the research conducted by several groups in the last fifteen years. The second section describes the in vitro model used in our studies, dosimetric calculations, experimental techniques and recent findings. The third section focuses on the use of Auger electron emitters as in vitro microprobes for the investigation of the radiosensitivity of distinct subcellular components. Examination of the biological effects of the Auger electron emitter 125 I located in different cellular compartments of a single cell line (V 79 hamster lung fibroblast) verifies that DNA is the critical cell structure for radiation damage and that the sensitive sites are of nanometer dimensions. The data from incorporation of several Auger electron emitters at the same location within DNA suggest that there are no saturation effects from the decay of these isotopes (i.e. all the emitted energy is biologically effective) and provide some insight into which of the numerous physical mechanisms accompanying the Auger decay are most important in causing cell damage. Finally the implications of Auger electron emission for radiotherapy and radiation protection in diagnostic nuclear medicine are detailed and further research possibilities are suggested. (orig.)

  13. Accurate measurement of directional emittance of solar energy materials

    NARCIS (Netherlands)

    Nijnatten, van P.A.; Hugo-Le Gof, A.; Granqvist, C.-G.; Lampert, C.M.

    1992-01-01

    Directional emittance plays an important role in the calculation of radiative heat exchange. It partly determines the thermal insulation of single and multiple glazing and the efficiency of solar collectors. An emissiometer has been designed and built, capable for measurements of the directional

  14. Development of new microencapsulated beta emitters for internal radiotherapy

    International Nuclear Information System (INIS)

    Perdrisot, R.; Monteil, J.; Le Jeune, J.J.; Pouliquen, D.; Jallet, P.; Beau, P.; Lepape, A.

    1993-01-01

    We have developed new microencapsulated beta emitter radiotracers which could be used in nuclear medicine for selective internal radiotherapy. Their efficacy was evaluated on B16 melanoma tumor model in mice, using phosphorus 31 spectroscopy. This kind of tracer would allow a precise targetting of beta irradiation

  15. Passive emitter location with Doppler frequency and interferometric measurements

    NARCIS (Netherlands)

    Groot, J.S.; Dam, F.A.M.; Theil, A.

    2008-01-01

    Ground based emitters can be located with a receiver installed on an airborne platform. This paper discusses techniques based on Doppler frequency and differential phase measurements (interferometry). Measurements of the first technique are provided, while we discuss and compare the theoretical

  16. The effects of emitter-tied field plates on lateral PNP ionizing radiation response

    International Nuclear Information System (INIS)

    Barnaby, H.J.; Schrimpf, R.D.; Cirba, C.R.; Pease, R.L.; Fleetwood, D.M.; Kosier, S.L.

    1998-03-01

    Radiation response comparisons of lateral PNP bipolar technologies reveal that device hardening may be achieved by extending the emitter contact over the active base. The emitter-tied field plate suppresses recombination of carriers with interface traps

  17. Seizure threshold and the half-age method in bilateral electroconvulsive therapy in Japanese patients.

    Science.gov (United States)

    Yasuda, Kazuyuki; Kobayashi, Kaoru; Yamaguchi, Masayasu; Tanaka, Koichi; Fujii, Tomokazu; Kitahara, Yuichi; Tamaoki, Toshio; Matsushita, Yutaka; Nunomura, Akihiko; Motohashi, Nobutaka

    2015-01-01

    Seizure threshold (ST) in electroconvulsive therapy (ECT) has not been reported previously in Japanese patients. We investigated ST in bilateral ECT in Japanese patients using the dose-titration method. The associations between demographic and clinical characteristics and ST were analyzed to identify the predictors of ST. Finally, the validity of the half-age method for the stimulus dose was evaluated. Fifty-four Japanese patients with mood disorder, schizophrenia, and other psychotic disorders received an acute course of bilateral ECT using a brief-pulse device. ST was determined at the first session using a fixed titration schedule. ST was correlated with age, sex, body mass index, history of previous ECT, and psychotropic drugs on multiple regression analysis. Furthermore, the rate of accomplished seizures was calculated using the half-age method. Mean ST was 136 mC. ST was influenced by age, sex, history of previous ECT, and medication with benzodiazepines. The accomplished seizure rate using the half-age method was 72%, which was significantly lower in men and subjects on benzodiazepines. ST in Japanese patients was equal to or slightly higher than that previously reported in other ethnic groups, which might be attributable, at least in part, to high prevalence of and large-dose benzodiazepine prescription. Higher age, male gender, no history of ECT, and benzodiazepines were related to higher ST. The half-age method was especially useful in female patients and subjects without benzodiazepine medication. © 2014 The Authors. Psychiatry and Clinical Neurosciences © 2014 Japanese Society of Psychiatry and Neurology.

  18. Analysis of Field Emission of Fabricated Nanogap in Pd Strips for Surface Conduction Electron-Emitter Displays

    Science.gov (United States)

    Lo, Hsiang-Yu; Li, Yiming; Tsai, Chih-Hao; Pan, Fu-Ming

    2008-04-01

    We study the field emission (FE) property of a nanometer-scale gap structure in a palladium strip, which was fabricated by hydrogen absorption under high-pressure treatment. A vigorous cracking process could be accompanied by extensive atomic migration during the hydrogen treatment. A three-dimensional finite-difference time-domain particle-in-cell method is adopted to simulate the electron emission in a surface-conduction electron-emitter display (SED) device. Examinations of conducting characteristics, FE efficiency, the local field around the emitter, and the current density on the anode plate with one FE emitter are conducted. The image of a light spot is successfully produced on a phosphor plate, which implies that the explored electrode with nanometer separation possesses a potential SED application. Experimental observation and numerical simulation show that the proposed structure can be used as a surface conduction electron emitter and has a high FE efficiency with low turn-on voltage and a different electron emission mechanism. This study benefits the advanced SED design for a new type of electron source.

  19. Emitter/absorber interface of CdTe solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Song, Tao, E-mail: tsong241@gmail.com; Sites, James R. [Physics Department, Colorado State University, Fort Collins, Colorado 80523 (United States); Kanevce, Ana [National Renewable Energy Laboratory, Golden, Colorado 80401 (United States)

    2016-06-21

    The performance of CdTe solar cells can be very sensitive to the emitter/absorber interface, especially for high-efficiency cells with high bulk lifetime. Performance losses from acceptor-type interface defects can be significant when interface defect states are located near mid-gap energies. Numerical simulations show that the emitter/absorber band alignment, the emitter doping and thickness, and the defect properties of the interface (i.e., defect density, defect type, and defect energy) can all play significant roles in the interface recombination. In particular, a type I heterojunction with small conduction-band offset (0.1 eV ≤ ΔE{sub C} ≤ 0.3 eV) can help maintain good cell efficiency in spite of high interface defect density, much like with Cu(In,Ga)Se{sub 2} (CIGS) cells. The basic principle is that positive ΔE{sub C}, often referred to as a “spike,” creates an absorber inversion and hence a large hole barrier adjacent to the interface. As a result, the electron-hole recombination is suppressed due to an insufficient hole supply at the interface. A large spike (ΔE{sub C} ≥ 0.4 eV), however, can impede electron transport and lead to a reduction of photocurrent and fill-factor. In contrast to the spike, a “cliff” (ΔE{sub C} < 0 eV) allows high hole concentration in the vicinity of the interface, which will assist interface recombination and result in a reduced open-circuit voltage. Another way to mitigate performance losses due to interface defects is to use a thin and highly doped emitter, which can invert the absorber and form a large hole barrier at the interface. CdS is the most common emitter material used in CdTe solar cells, but the CdS/CdTe interface is in the cliff category and is not favorable from the band-offset perspective. The ΔE{sub C} of other n-type emitter choices, such as (Mg,Zn)O, Cd(S,O), or (Cd,Mg)Te, can be tuned by varying the elemental ratio for an optimal positive value of ΔE{sub C}. These

  20. Low Emittance Guns for the ILC Polarized Electron Beam

    International Nuclear Information System (INIS)

    Clendenin, J. E.; Brachmann, A.; Ioakeimidi, K.; Kirby, R. E.; Maruyama, T.; Miller, R. H.; Wang, J. W.; Zhou, F.

    2007-01-01

    Polarized electron beams generated by DC guns are routinely available at several accelerators including JLAB, Mainz and SLAC. These guns operate with a cathode bias on the order of -100 kV. To minimize space charge effects, relatively long bunches are generated at the gun and then compressed longitudinally external to the gun just before and during initial acceleration. For linear colliders, this compression is accomplished using a combination of rf bunchers. For the basic design of the International Linear Collider (ILC), a 120 kV DC photocathode gun is used to produce a series of nanosecond bunches that are each compressed by two sub-harmonic bunchers (SHBs) followed by an L-band buncher and capture section. The longitudinal bunching process results in a significantly higher emittance than produced by the gun alone. While high-energy experiments using polarized beams are not generally sensitive to the source emittance, there are several benefits to a lower source emittance including a simpler more efficient injector system and a lower radiation load during transport especially at bends as at the damping ring. For the ILC, the SHBs could be eliminated if the voltage of the gun is raised sufficiently. Simulations using the General Particle Tracer (GPT) package indicate that a cathode bias voltage of ≥200 kV should allow both SHBs to be operated at 433 or even 650 MHz, while ≥500 kV would be required to eliminate the SHBs altogether. Simulations can be used to determine the minimum emittance possible if the injector is designed for a given increased voltage. A possible alternative to the DC gun is an rf gun. Emittance compensation, routinely used with rf guns, is discussed for higher-voltage DC guns

  1. Preservation of low slice emittance in bunch compressors

    Directory of Open Access Journals (Sweden)

    S. Bettoni

    2016-03-01

    Full Text Available Minimizing the dilution of the electron beam emittance is crucial for the performance of accelerators, in particular for free electron laser facilities, where the length of the machine and the efficiency of the lasing process depend on it. Measurements performed at the SwissFEL Injector Test Facility revealed an increase in slice emittance after compressing the bunch even for moderate compression factors. The phenomenon was experimentally studied by characterizing the dependence of the effect on beam and machine parameters relevant for the bunch compression. The reproduction of these measurements in simulation required the use of a 3D beam dynamics model along the bunch compressor that includes coherent synchrotron radiation. Our investigations identified transverse effects, such as coherent synchrotron radiation and transverse space charge as the sources of the observed emittance dilution, excluding other effects, such as chromatic effects on single slices or spurious dispersion. We also present studies, both experimental and simulation based, on the effect of the optics mismatch of the slices on the variation of the slice emittance along the bunch. After a corresponding reoptimization of the beam optics in the test facility we reached slice emittances below 200 nm for the central slices along the longitudinal dimension with a moderate increase up to 300 nm in the head and tail for a compression factor of 7.5 and a bunch charge of 200 pC, equivalent to a final current of 150 A, at about 230 MeV energy.

  2. Low Emittance Guns for the ILC Polarized Electron Beam

    International Nuclear Information System (INIS)

    Clendenin, J.E.; Brachmann, A.; Ioakeimidi, K.; Kirby, R.E.; Maruyama, T.; Miller, R.H.; Wang, J.W.; Zhou, F.; SLAC

    2006-01-01

    Polarized electron beams generated by DC guns are routinely available at several accelerators including JLAB, Mainz and SLAC. These guns operate with a cathode bias on the order of -100 kV. To minimize space charge effects, relatively long bunches are generated at the gun and then compressed longitudinally external to the gun just before and during initial acceleration. For linear colliders, this compression is accomplished using a combination of rf bunchers. For the basic design of the International Linear Collider (ILC), a 120 kV DC photocathode gun is used to produce a series of nanosecond bunches that are each compressed by two sub-harmonic bunchers (SHBs) followed by an L-band buncher and capture section. The longitudinal bunching process results in a significantly higher emittance than produced by the gun alone. While high-energy experiments using polarized beams are not generally sensitive to the source emittance, there are several benefits to a lower source emittance including a simpler more efficient injector system and a lower radiation load during transport especially at bends as at the damping ring. For the ILC, the SHBs could be eliminated if the voltage of the gun is raised sufficiently. Simulations using the General Particle Tracer (GPT) package indicate that a cathode bias voltage of (ge)200 kV should allow both SHBs to be operated at 433 or even 650 MHz, while (ge)500 kV would be required to eliminate the SHBs altogether. Simulations can be used to determine the minimum emittance possible if the injector is designed for a given increased voltage. A possible alternative to the DC gun is an rf gun. Emittance compensation, routinely used with rf guns, is discussed for higher-voltage DC guns

  3. Pilates and mobilization methods in therapy for low back pain among pregnant women

    Directory of Open Access Journals (Sweden)

    Martyna Mączka

    2017-08-01

    Full Text Available INTRODUCTION: Bad body posture, insufficient physical activity, excessive body weight gain of pregnant women, with overloads due to pregnancy in their body, results in pain of fatigued muscle. The enlarged uterus with fetus cause the forward shifts of the gravity center which leads to the pelvis forward tilt. This mechanism women compensate by the body posture deflection that leads to lumbar hyperlordosis. In adaptation to the new biomechanical conditions, the iliolumbar and erector spinae muscles are contracted, while the gluteus maximus and abdominal muscles are overstretched. All of these changes are further coused by the increasing levels of relaxin and estrogen hormones in pregnancy, which relax the ligaments and muscles. Muscle weakness and presence of pathological overloads in body leads to lower back pain of the spine. OBJECTIVE: The assessment of lumbar spine pain among women in the third trimester of pregnancy in context of comprehensive therapy of Pilates exercises and lumbar mobilization. MATERIAL AND METHODS: The qualifying interview identified a group of 224 pregnant women with lumbar spine complications. The study was conducted in a targeted manner and all the participants did not have any contraindications from a gynecologist to physical activity during pregnancy. Women who reported sedentary lifestyle, according to pedometer classification, were assigned to a control group (GK with only a lumbar mobilization intervention. On the other hand, women who were active, were arranged in the Pilates exercise also with lumbar mobilization (GP. Respondents received the Oswestry questionnaire to assess the low back pain. The questionnaire was twice conducted - at 26 Hbd and after the period of interventions in 39 Hbd. In addition, women subjectively assessed the severity of pain sensations in the visual analogue pain scale from 0-10. The obtained data were statistically analyzed. THE RESULTS of the evaluation of lumbar spine pain in 39 Hbd

  4. Assessment of cone beam CT registration for prostate radiation therapy: fiducial marker and soft tissue methods.

    Science.gov (United States)

    Deegan, Timothy; Owen, Rebecca; Holt, Tanya; Fielding, Andrew; Biggs, Jennifer; Parfitt, Matthew; Coates, Alicia; Roberts, Lisa

    2015-02-01

    This investigation aimed to assess the consistency and accuracy of radiation therapists (RTs) performing cone beam computed tomography (CBCT) alignment to fiducial markers (FMs) (CBCTFM ) and the soft tissue prostate (CBCTST ). Six patients receiving prostate radiation therapy underwent daily CBCTs. Manual alignment of CBCTFM and CBCTST was performed by three RTs. Inter-observer agreement was assessed using a modified Bland-Altman analysis for each alignment method. Clinically acceptable 95% limits of agreement with the mean (LoAmean ) were defined as ±2.0 mm for CBCTFM and ±3.0 mm for CBCTST . Differences between CBCTST alignment and the observer-averaged CBCTFM (AvCBCTFM ) alignment were analysed. Clinically acceptable 95% LoA were defined as ±3.0 mm for the comparison of CBCTST and AvCBCTFM . CBCTFM and CBCTST alignments were performed for 185 images. The CBCTFM 95% LoAmean were within ±2.0 mm in all planes. CBCTST 95% LoAmean were within ±3.0 mm in all planes. Comparison of CBCTST with AvCBCTFM resulted in 95% LoA of -4.9 to 2.6, -1.6 to 2.5 and -4.7 to 1.9 mm in the superior-inferior, left-right and anterior-posterior planes, respectively. Significant differences were found between soft tissue alignment and the predicted FM position. FMs are useful in reducing inter-observer variability compared with soft tissue alignment. Consideration needs to be given to margin design when using soft tissue matching due to increased inter-observer variability. This study highlights some of the complexities of soft tissue guidance for prostate radiation therapy. © 2014 The Royal Australian and New Zealand College of Radiologists.

  5. Assessment of cone beam CT registration for prostate radiation therapy: fiducial marker and soft tissue methods

    International Nuclear Information System (INIS)

    Deegan, Timothy; Owen, Rebecca; Holt, Tanya; Fielding, Andrew; Biggs, Jennifer; Parfitt, Matthew; Coates, Alicia; Roberts, Lisa

    2015-01-01

    This investigation aimed to assess the consistency and accuracy of radiation therapists (RTs) performing cone beam computed tomography (CBCT) alignment to fiducial markers (FMs) (CBCT FM ) and the soft tissue prostate (CBCT ST ). Six patients receiving prostate radiation therapy underwent daily CBCTs. Manual alignment of CBCT FM and CBCT ST was performed by three RTs. Inter-observer agreement was assessed using a modified Bland–Altman analysis for each alignment method. Clinically acceptable 95% limits of agreement with the mean (LoA mean ) were defined as ±2.0 mm for CBCT FM and ±3.0 mm for CBCT ST . Differences between CBCT ST alignment and the observer-averaged CBCT FM (AvCBCT FM ) alignment were analysed. Clinically acceptable 95% LoA were defined as ±3.0 mm for the comparison of CBCT ST and AvCBCT FM . CBCT FM and CBCT ST alignments were performed for 185 images. The CBCT FM 95% LoA mean were within ±2.0 mm in all planes. CBCT ST 95% LoA mean were within ±3.0 mm in all planes. Comparison of CBCT ST with AvCBCT FM resulted in 95% LoA of −4.9 to 2.6, −1.6 to 2.5 and −4.7 to 1.9 mm in the superior–inferior, left–right and anterior–posterior planes, respectively. Significant differences were found between soft tissue alignment and the predicted FM position. FMs are useful in reducing inter-observer variability compared with soft tissue alignment. Consideration needs to be given to margin design when using soft tissue matching due to increased inter-observer variability. This study highlights some of the complexities of soft tissue guidance for prostate radiation therapy.

  6. A comparison of two methods for estimating the technical costs of external beam radiation therapy

    International Nuclear Information System (INIS)

    Hayman, James A.; Lash, Kathy A.; Tao, May L.; Halman, Marc A.

    2000-01-01

    Purpose: To accurately assess the cost-effectiveness of treatment with external beam radiation, it is necessary to have accurate estimates of its cost. One of the most common methods for estimating technical costs has been to convert Medicare charges into costs using Medicare Cost-to-Charge Ratios (CCR). More recently, health care organizations have begun to invest in sophisticated cost-accounting systems (CAS) that are capable of providing procedure-specific cost estimates. The purpose of this study was to examine whether these competing approaches result in similar cost estimates for four typical courses of external beam radiation therapy (EBRT). Methods and Materials: Technical costs were estimated for the following treatment courses: 1) a palliative 'simple' course of 10 fractions using a single field without blocks; 2) a palliative 'complex' course of 10 fractions using two opposed fields with custom blocks; 3) a curative course of 30 fractions for breast cancer using tangent fields followed by an electron beam boost; and 4) a curative course of 35 fractions for prostate cancer using CT-planning and a 4-field technique. Costs were estimated using the CCR approach by multiplying the number of units of each procedure billed by its Medicare charge and CCR and then summing these costs. Procedure-specific cost estimates were obtained from a cost-accounting system, and overall costs were then estimated for the CAS approach by multiplying the number of units billed by the appropriate unit cost estimate and then summing these costs. All costs were estimated using data from 1997. The analysis was also repeated using data from another academic institution to estimate their costs using the CCR and CAS methods, as well as the appropriate relative value units (RVUs) and conversion factor from the 1997 Medicare Fee Schedule to estimate Medicare reimbursement for the four treatment courses. Results: The estimated technical costs for the CCR vs. CAS approaches for the four

  7. [Treatment and personality development with art therapy. A description of the method].

    Science.gov (United States)

    Antalfai, Márta

    2007-01-01

    Composition as a creative form of self-expression plays an important role not only in maintaining health, but also in gaining insight into the healthy personality and in the definition of this category. It seems nowadays that psychology has collected more information on the pathological personality than on the healthy one. Therefore, different workshops of art therapy are also scenes of a "spiritual alchemy" because they can give a deeper insight into the personality in addition to the primary aim of treatment. The method of the thematic art psychotherapy based on catharsis-experience is based on analytical psychology and on analytically oriented group-therapy. The aim is to generate artificial catharsis-experiences employing the impressive forces of poems, music compositions in order to raise the unconscious or the partly experienced partner-conflicts to the surface, which could manifest themselves in the process of the creative work and could be elaborated in group-activity. The creative process (specially adapted art techniques) provides good opportunities for patients to depict their traumas and complexes and also to resolve them involving the whole personality and not only at a cognitive level. The method, tuned to the workings of nature, helps the personality to develop the emotional and volitional segments, the sensitive and empathetic capabilities, as well as the recognition skills of consciousness. In the therapeutic process, the work of art that is created holds a mirror to the creator, offering to him or her the opportunity to face the real complex at the background the actual conflict. The method aims to achieve a reconstruction of psychic dynamics in two ways. The first is an emotional resonance to the changes of nature, of the year and of the feasts, in which the psychic process starts from inside to the direction of the outside world (psychic enrichment and accomodation). The second way leads from the outer world to the inner one and this psychic

  8. On the design guideline for the low emittance synchrotron radiation source

    International Nuclear Information System (INIS)

    Kamiya, Y.; Kihara, M.

    1983-09-01

    In this note we will describe how the emittance of the electron storage ring is determined by the orbit parameters of the storage ring and show the lowest value of emittance which is achieved theoretically. Implication of this note with regard to the design of the low emittance storage ring will be discussed. (author)

  9. Emotional Prosody Measurement (EPM): a voice-based evaluation method for psychological therapy effectiveness.

    Science.gov (United States)

    van den Broek, Egon L

    2004-01-01

    The voice embodies three sources of information: speech, the identity, and the emotional state of the speaker (i.e., emotional prosody). The latter feature is resembled by the variability of the F0 (also named fundamental frequency of pitch) (SD F0). To extract this feature, Emotional Prosody Measurement (EPM) was developed, which consists of 1) speech recording, 2) removal of speckle noise, 3) a Fourier Transform to extract the F0-signal, and 4) the determination of SD F0. After a pilot study in which six participants mimicked emotions by their voice, the core experiment was conducted to see whether EPM is successful. Twenty-five patients suffering from a panic disorder with agoraphobia participated. Two methods (story-telling and reliving) were used to trigger anxiety and were compared with comparable but more relaxed conditions. This resulted in a unique database of speech samples that was used to compare the EPM with the Subjective Unit of Distress to validate it as measure for anxiety/stress. The experimental manipulation of anxiety proved to be successful and EPM proved to be a successful evaluation method for psychological therapy effectiveness.

  10. Virtual reality as a method for evaluation and therapy after traumatic hand surgery.

    Science.gov (United States)

    Nica, Adriana Sarah; Brailescu, Consuela Monica; Scarlet, Rodica Gabriela

    2013-01-01

    In the last decade, Virtual Reality has encountered a continuous development concerning medical purposes and there are a lot of devices based on the classic "cyberglove" concept that are used as new therapeutic method for upper limb pathology, especially neurologic problems [1;2;3]. One of the VR devices is Pablo (Tyromotion), with very sensitive sensors that can measure the hand grip strenght and the pinch force, also the ROM (range of motion) for all the joints of the upper limb (shoulder, elbow, wrist) and offering the possibility of interactive games based on Virtual Reality concept with application in occupational therapy programs. We used Pablo in our study on patients with hand surgery as an objective tool for assessment and as additional therapeutic method to the classic Rehabilitation program [4;5]. The results of the study proved that Pablo represents a modern option for evaluation of hand deficits and dysfunctions, with objective measurement replacement of classic goniometry and dynamometry, with computerized data base of patients with monitoring of parameters during the recovery program and with better muscular and neuro-cognitive feedback during the interactive therapeutic modules.

  11. Components of Effective Cognitive-Behavioral Therapy for Pediatric Headache: A Mixed Methods Approach.

    Science.gov (United States)

    Law, Emily F; Beals-Erickson, Sarah E; Fisher, Emma; Lang, Emily A; Palermo, Tonya M

    2017-01-01

    Internet-delivered treatment has the potential to expand access to evidence-based cognitive-behavioral therapy (CBT) for pediatric headache, and has demonstrated efficacy in small trials for some youth with headache. We used a mixed methods approach to identify effective components of CBT for this population. In Study 1, component profile analysis identified common interventions delivered in published RCTs of effective CBT protocols for pediatric headache delivered face-to-face or via the Internet. We identified a core set of three treatment components that were common across face-to-face and Internet protocols: 1) headache education, 2) relaxation training, and 3) cognitive interventions. Biofeedback was identified as an additional core treatment component delivered in face-to-face protocols only. In Study 2, we conducted qualitative interviews to describe the perspectives of youth with headache and their parents on successful components of an Internet CBT intervention. Eleven themes emerged from the qualitative data analysis, which broadly focused on patient experiences using the treatment components and suggestions for new treatment components. In the Discussion, these mixed methods findings are integrated to inform the adaptation of an Internet CBT protocol for youth with headache.

  12. A modified method of planning and delivery for dynamic multileaf collimator intensity-modulated radiation therapy

    International Nuclear Information System (INIS)

    Dogan, Nesrin; Leybovich, Leonid B.; Sethi, Anil; Krasin, Matthew; Emami, Bahman

    2000-01-01

    Purpose: To develop a modified planning and delivery technique that reduces dose nonuniformity for tomographic delivery of intensity-modulated radiation therapy (IMRT). Methods and Materials: The NOMOS-CORVUS system delivers IMRT in a tomographic paradigm. This type of delivery is prone to create multiple dose nonuniformity regions at the arc abutment regions. The modified technique was based on the cyclical behavior of arc positions as a function of a target length. With the modified technique, two plans are developed for the same patient, one with the original target and the second with a slightly increased target length and the abutment regions shifted by ∼5 mm compared to the first plan. Each plan is designed to deliver half of the target prescription dose delivered on alternate days, resulting in periodic shifts of abutment regions. This method was experimentally tested in phantoms with and without intentionally introduced errors in couch indexing. Results: With the modified technique, the degree of dose nonuniformity was reduced. For example, with 1 mm error in couch indexing, the degree of dose nonuniformity changed from ∼25% to ∼12%. Conclusion: Use of the modified technique reduces dose nonuniformity due to periodic shifts of abutment regions during treatment delivery

  13. Potential Suitable Methods for Measuring the Effects of Animal-Assisted Activities and Therapy: a Review

    Directory of Open Access Journals (Sweden)

    Machová K.

    2016-09-01

    Full Text Available Dogs are companions of humans since time beyond memory and their use in rehabilitation processes is increasingly frequent. Dogs can be used for animal-assisted activities (AAA as well as animal-assisted therapy (AAT. The effects, however, have not been fully demonstrated, reasons for this including difficulties in providing evidence of positive action. According to previous studies, there is a decrease in heart and respiratory rate, blood pressure reduction, more positive mood as well as warming of muscles, which promotes relaxation of spastic areas. Regulation of hormone levels might also occur as a result of AAA/AAT. Indeed, increases in oxytocin levels and decreases of cortisol have been found. However, a unified methodology for clear measuring the entire impact of AAA/AAT on patients is missing. This survey evaluated different methods for measuring the effects of AAA/AAT, with results showing that the most suitable ones, selected on the basis of the effect of rehabilitation, comprise thermography, spectral analysis of heart rate, electromyography (EMG, polyelectromyography (PEMG, and blood sampling. Because AAT making use of dogs has not yet been recognized as an official method of treatment, it is very important to find out objective means to evidence its beneficial effects. Highlights:

  14. Radiopharmaceuticals for palliative therapy pain

    International Nuclear Information System (INIS)

    Gaudiano, Javier

    1994-01-01

    Dissemination to bone of various neoplasms is cause of pain with poor response by major analgesics.Indications. Radiopharmaceuticals,description of main characteristics of various β emitter radionuclides.Choose of patients for worm indication of pain palliative therapy with β emitter radiopharmaceuticals is adequate must be careful . Contraindications are recognized.Pre and post treatment controls as clinical examination and complete serology are described.It is essential to subscribe protocols,keep patient well informed,included the physician in charge of the patient as part of the team.Bibliography

  15. [The significance of the Montessori method and phenomenon with a particular view to the therapy of the aphasics (author's transl)].

    Science.gov (United States)

    Birchmeier-Nussbaumer, A K

    1980-05-01

    The methods of the Italian physician Maria Montessori influenced the development of modern learning practices. There is general agreement that the Montessori phenomenon is personality forming. Aspects of this method, which are relevant for the rehabilitation of the brain-damaged and, in particular, the aphasics are presented. Possible shifts of emphasis within the relationship therapist - method - patient are analysed. Examples are used to outline in how far an increasingly patient-oriented therapy can influence the development of the aphasic patient.

  16. Quantifying, Assessing, and Mitigating Methane Emissions from Super-emitters in the Oil and Gas Supply Chain

    Science.gov (United States)

    Lyon, David Richard

    Methane emissions from the oil and gas (O&G) supply chain reduce potential climate benefits of natural gas as a replacement for other fossil fuels that emit more carbon dioxide per energy produced. O&G facilities have skewed emission rate distributions with a small fraction of sites contributing the majority of emissions. Knowledge of the identity and cause of these high emission facilities, referred to as super-emitters or fat-tail sources, is critical for reducing supply chain emissions. This dissertation addresses the quantification of super-emitter emissions, assessment of their prevalence and relationship to site characteristics, and mitigation with continuous leak detection systems. Chapter 1 summarizes the state of the knowledge of O&G methane emissions. Chapter 2 constructs a spatially-resolved emission inventory to estimate total and O&G methane emissions in the Barnett Shale as part of a coordinated research campaign using multiple top-down and bottom-up methods to quantify emissions. The emission inventory accounts for super-emitters with two-phase Monte Carlo simulations that combine site measurements collected with two approaches: unbiased sampling and targeted sampling of super-emitters. More comprehensive activity data and the inclusion of super-emitters, which account for 19% of O&G emissions, produces a emission inventory that is not statistically different than top-down regional emission estimates. Chapter 3 describes a helicopter-based survey of over 8,000 well pads in seven basins with infrared optical gas imaging to assess high emission sources. Four percent of sites are observed to have high emissions with over 90% of observed sources from tanks. The occurrence of high emissions is weakly correlated to site parameters and the best statistical model explains only 14% of variance, which demonstrates that the occurrence of super-emitters is primarily stochastic. Chapter 4 presents a Gaussian dispersion model for optimizing the placement of

  17. Production of positron emitters of metallic elements to study plant uptake and distribution

    International Nuclear Information System (INIS)

    Watanabe, S.; Ishioka, N.S.; Sekine, T.; Osa, A.; Koizumi, M.; Kiyomiya, S.; Nakanishi, H.; Mori, S.

    2001-01-01

    The metallic positron emitters 52 Mn, 52 Fe and 62 Zn, the elements of which are essential nutrients for plants as well as for animals, have been produced for a new tracer method in plant physiology. The tracer method utilizes the detection of annihilation γ-rays, like PET in nuclear medicine, to obtain two-dimensional images on a plant as well as to obtain radioactivity counts at specified points in a plant; this method allows us to observe the tracer movement in a living plant without touching the test plant. The previously reported methods of radiochemical separation of these metallic positron emitters from targets were partly modified from the view of their use in plant physiology. Radionuclidic impurities remaining in the final solutions were examined by γ-ray spectrometry, and their influences on the above-mentioned measurements are discussed. From the experiments on a barley plant, the speeds of 52 Mn 2+ ion and 52 Fe 3+ - mugineic-acid complex have been obtained for the first time to be 0.2 cm/min and 1.0 cm/min, respectively. (orig.)

  18. Observation of Interactions in Adolescent Group Therapy: A Mixed Methods Study

    Directory of Open Access Journals (Sweden)

    Eulàlia Arias-Pujol

    2017-07-01

    Full Text Available Group psychotherapy is a useful clinical practice for adolescents with mental health issues. Groups typically consist of young people of similar ages but with different personalities, and this results in a complex communication network. The goal of group psychoanalytic psychotherapy is to improve participants' mentalization abilities, facilitating interactions between peers and their therapist in a safe, containing environment. The main aim of this study was to analyze conversation turn-taking between a lead therapist, a co-therapist, and six adolescents over the course of 24 treatment sessions divided into four blocks over 8 months. We employed a mixed-methods design based on systematic observation, which we consider to be a mixed method itself, as the qualitative data collected in the initial observation phase is transformed into quantitative data and subsequently interpreted qualitatively with the aid of clinical vignettes. The observational methodology design was nomothetic, follow-up, and multidimensional. The choice of methodology is justified as we used an ad-hoc observation instrument combining a field format and a category system. Interobserver agreement was analyzed quantitatively by Cohen's kappa using the free QSEQ5 software program. Once we had confirmed the reliability of the data, these were analyzed by polar coordinate analysis, which is a powerful data reduction technique that provides a vector representation of relationships between categories. The results show significant relationships between the therapist and (1 the activation of turn-taking by the participants and the co-therapist and silence and (2 conversation-facilitating interventions and interventions designed to improve mentalization abilities. Detailed analysis of questions demonstrating interest in others showed how the communication changed from radial interactions stemming from the therapist at the beginning of therapy to circular interactions half way through

  19. Spinal Tissue Loading Created by Different Methods of Spinal Manipulative Therapy Application.

    Science.gov (United States)

    Funabashi, Martha; Nougarou, François; Descarreaux, Martin; Prasad, Narasimha; Kawchuk, Gregory N

    2017-05-01

    Comparative study using robotic replication of spinal manipulative therapy (SMT) vertebral kinematics together with serial dissection. The aim of this study was to quantify loads created in cadaveric spinal tissues arising from three different forms of SMT application. There exist many distinct methods by which to apply SMT. It is not known presently whether different forms of SMT application have different effects on spinal tissues. Should the method of SMT application modulate spinal tissue loading, quantifying this relation may help explain the varied outcomes of SMT in terms of effect and safety. SMT was applied to the third lumbar vertebra in 12 porcine cadavers using three SMT techniques: a clinical device that applies forces through a hand-held instrument (INST), a manual technique of applying SMT clinically (MAN) and a research device that applies parameters of manual SMT through a servo-controlled linear actuator motor (SERVO). The resulting kinematics from each SMT application were tracked optically via indwelling bone pins. The L3/L4 segment was then removed, mounted in a parallel robot and the resulting kinematics from SMT replayed for each SMT application technique. Serial dissection of spinal structures was conducted to quantify loading characteristics of discrete spinal tissues. In terms of load magnitude, SMT application with MAN and SERVO created greater forces than INST in all conditions (P < 0.05). Additionally, MAN and SERVO created comparable posterior forces in the intact specimen, but MAN created greater posterior forces on IVD structures compared to SERVO (P < 0.05). Specific methods of SMT application create unique vertebral loading characteristics, which may help explain the varied outcomes of SMT in terms of effect and safety. N/A.

  20. Dose calculation methods in photon beam therapy using energy deposition kernels

    International Nuclear Information System (INIS)

    Ahnesjoe, A.

    1991-01-01

    The problem of calculating accurate dose distributions in treatment planning of megavoltage photon radiation therapy has been studied. New dose calculation algorithms using energy deposition kernels have been developed. The kernels describe the transfer of energy by secondary particles from a primary photon interaction site to its surroundings. Monte Carlo simulations of particle transport have been used for derivation of kernels for primary photon energies form 0.1 MeV to 50 MeV. The trade off between accuracy and calculational speed has been addressed by the development of two algorithms; one point oriented with low computional overhead for interactive use and one for fast and accurate calculation of dose distributions in a 3-dimensional lattice. The latter algorithm models secondary particle transport in heterogeneous tissue by scaling energy deposition kernels with the electron density of the tissue. The accuracy of the methods has been tested using full Monte Carlo simulations for different geometries, and found to be superior to conventional algorithms based on scaling of broad beam dose distributions. Methods have also been developed for characterization of clinical photon beams in entities appropriate for kernel based calculation models. By approximating the spectrum as laterally invariant, an effective spectrum and dose distribution for contaminating charge particles are derived form depth dose distributions measured in water, using analytical constraints. The spectrum is used to calculate kernels by superposition of monoenergetic kernels. The lateral energy fluence distribution is determined by deconvolving measured lateral dose distributions by a corresponding pencil beam kernel. Dose distributions for contaminating photons are described using two different methods, one for estimation of the dose outside of the collimated beam, and the other for calibration of output factors derived from kernel based dose calculations. (au)