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Sample records for em structure based

  1. Physics-based simulation of EM and SM in TSV-based 3D IC structures

    Energy Technology Data Exchange (ETDEWEB)

    Kteyan, Armen [Mentor Graphics Corp., 0012 Yerevan (Armenia); Sukharev, Valeriy [Mentor Graphics Corp., Fremont, CA 94538 (United States); Zschech, Ehrenfried [Fraunhofer Institute for Nondestructive Testing IZFP, D-01109 Dresden (Germany)

    2014-06-19

    Evolution of stresses in through-silicon-vias (TSVs) and in the TSV landing pad due to the stress migration (SM) and electromigration (EM) phenomena are considered. It is shown that an initial stress distribution existing in a TSV depends on its architecture and copper fill technology. We demonstrate that in the case of proper copper annealing the SM-induced redistribution of atoms results in uniform distributions of the hydrostatic stress and concentration of vacancies along each segment. In this case, applied EM stressing generates atom migration that is characterized by kinetics depending on the preexisting equilibrium concentration of vacancies. Stress-induced voiding in TSV is considered. EM induced voiding in TSV landing pad is analyzed in details.

  2. Physics-based simulation of EM and SM in TSV-based 3D IC structures

    International Nuclear Information System (INIS)

    Kteyan, Armen; Sukharev, Valeriy; Zschech, Ehrenfried

    2014-01-01

    Evolution of stresses in through-silicon-vias (TSVs) and in the TSV landing pad due to the stress migration (SM) and electromigration (EM) phenomena are considered. It is shown that an initial stress distribution existing in a TSV depends on its architecture and copper fill technology. We demonstrate that in the case of proper copper annealing the SM-induced redistribution of atoms results in uniform distributions of the hydrostatic stress and concentration of vacancies along each segment. In this case, applied EM stressing generates atom migration that is characterized by kinetics depending on the preexisting equilibrium concentration of vacancies. Stress-induced voiding in TSV is considered. EM induced voiding in TSV landing pad is analyzed in details

  3. Synthesis, Crystal Structure and Luminescent Property of Cd (II Complex with <em>N-Benzenesulphonyl-L>-leucine

    Directory of Open Access Journals (Sweden)

    Xishi Tai

    2012-09-01

    Full Text Available A new trinuclear Cd (II complex [Cd3(L6(2,2-bipyridine3] [L =<em> Nem>-phenylsulfonyl-L>-leucinato] has been synthesized and characterized by elemental analysis, IR and X-ray single crystal diffraction analysis. The results show that the complex belongs to the orthorhombic, space group<em> Pem>212121 with<em> aem> = 16.877(3 Å, <em>b> em>= 22.875(5 Å, <em>c em>= 29.495(6 Å, <em>α> em>= <emem>= <emem>= 90°, <em>V> em>= 11387(4 Å3, <em>Z> em>= 4, <em>Dc>= 1.416 μg·m−3, <emem>= 0.737 mm−1, <em>F> em>(000 = 4992, and final <em>R>1 = 0.0390, <em>ωR>2 = 0.0989. The complex comprises two seven-coordinated Cd (II atoms, with a N2O5 distorted pengonal bipyramidal coordination environment and a six-coordinated Cd (II atom, with a N2O4 distorted octahedral coordination environment. The molecules form one dimensional chain structure by the interaction of bridged carboxylato groups, hydrogen bonds and p-p interaction of 2,2-bipyridine. The luminescent properties of the Cd (II complex and <em>N-Benzenesulphonyl-L>-leucine in solid and in CH3OH solution also have been investigated.

  4. CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1.

    Science.gov (United States)

    Huynh, Kevin W; Jiang, Jiansen; Abuladze, Natalia; Tsirulnikov, Kirill; Kao, Liyo; Shao, Xuesi; Newman, Debra; Azimov, Rustam; Pushkin, Alexander; Zhou, Z Hong; Kurtz, Ira

    2018-03-02

    Na + -coupled acid-base transporters play essential roles in human biology. Their dysfunction has been linked to cancer, heart, and brain disease. High-resolution structures of mammalian Na + -coupled acid-base transporters are not available. The sodium-bicarbonate cotransporter NBCe1 functions in multiple organs and its mutations cause blindness, abnormal growth and blood chemistry, migraines, and impaired cognitive function. Here, we have determined the structure of the membrane domain dimer of human NBCe1 at 3.9 Å resolution by cryo electron microscopy. Our atomic model and functional mutagenesis revealed the ion accessibility pathway and the ion coordination site, the latter containing residues involved in human disease-causing mutations. We identified a small number of residues within the ion coordination site whose modification transformed NBCe1 into an anion exchanger. Our data suggest that symporters and exchangers utilize comparable transport machinery and that subtle differences in their substrate-binding regions have very significant effects on their transport mode.

  5. Hubbard-<em>U> band-structure methods

    DEFF Research Database (Denmark)

    Albers, R.C.; Christensen, Niels Egede; Svane, Axel

    2009-01-01

    The last decade has seen a large increase in the number of electronic-structure calculations that involve adding a Hubbard term to the local-density approximation band-structure Hamiltonian. The Hubbard term is then determined either at the mean-field level or with sophisticated many......-body techniques such as using dynamical mean-field theory. We review the physics underlying these approaches and discuss their strengths and weaknesses in terms of the larger issues of electronic structure that they involve. In particular, we argue that the common assumptions made to justify such calculations...

  6. The vibrational structure of dibenzo-<em>p>-dioxin

    DEFF Research Database (Denmark)

    Eriksen, Troels Kongsgaard; Hansen, Bjarke Knud Vilster; Spanget-Larsen, Jens

    2008-01-01

    by the results of a harmonic analysis based on B3LYP/cc-pVTZ density functional theory (DFT). The combined experimental and theoretical results led to proposal of a nearly complete assignment of the fundamental vibrational transitions of DD, involving reassignment of several transitions. The results...

  7. A prática clínica baseada em evidências. Parte I: questões clínicas bem construídas Evidence based clinical practice. Part 1: well structured clinical questions

    Directory of Open Access Journals (Sweden)

    Moacyr Roberto Cuce Nobre

    2003-01-01

    Full Text Available Na prática diária as decisões tomadas para resolver o problema do paciente são usualmente baseadas na aplicação consciente da informação avaliável por regras explicitamente definidas. A prática clínica baseada em evidências leva em consideração o reconhecimento dos conhecimentos explícitos e tácitos, entendendo que é impossível tornar explícito todos os aspectos da competência profissional. A dúvida passa a fazer parte do processo de decisão, inicialmente na identificação dos componentes inconscientes envolvidos, e em seguida na análise do conhecimento explícito utilizado nesse processo. Ao elaborarmos uma questão clínica estruturada e que possa ser respondida, devemos lembrar que essa dúvida pode estar relacionada a aspectos básicos e de definição da doença ou relacionada ao atendimento do paciente, como em diagnóstico, terapêutica ou prognóstico. Ao longo de nossa vida médica, ambos os tipos de questões estão presentes, variando na proporção em que nossa experiência aumenta à medida do tempo de prática clínica. O processo de encontrar resposta apropriada à dúvida surgida no atendimento depende da forma como estruturamos as partes deste processo. A forma preconizada é conhecida pela sigla PICO. formada por P de paciente ou população, I de intervenção ou indicador, C de comparação ou controle e O de "outcome", que na língua inglesa significa desfecho clínico, resultado, ou por fim, a resposta que se espera encontrar nas fontes de informação científica. Esta é a primeira condição básica para que a nossa busca possa ser bem sucedida, a segunda é encontrar as palavras-chaves que melhor descrevem cada uma destas quatro características da questão. Sem estes cuidados as pesquisas em bases de dados informatizadas costuma resultar em ausência de informação ou em quantidade muito grande de informação que não está relacionada com o nosso interesse.Clinical decisions in daily practice

  8. A prática clínica baseada em evidências: parte I - questões clínicas bem construídas Evidence based clinical practice: part I - well structured clinical questions

    Directory of Open Access Journals (Sweden)

    Moacyr Roberto Cuce Nobre

    2004-12-01

    Full Text Available Na prática diária as decisões tomadas para resolver o problema do paciente são usualmente baseadas na aplicação consciente da informação avaliável por regras explicitamente definidas. A prática clínica baseada em evidências leva em consideração o reconhecimento dos conhecimentos explícitos e tácitos, entendendo que é impossível tornar explícito todos os aspectos da competência profissional. A dúvida passa a fazer parte do processo de decisão, inicialmente na identificação dos componentes inconscientes envolvidos, e em seguida na análise do conhecimento explícito utilizado nesse processo. Ao elaborarmos uma questão clínica estruturada e que possa ser respondida, devemos lembrar que essa dúvida pode estar relacionada a aspectos básicos e de definição da doença ou relacionada ao atendimento do paciente, como em diagnóstico, terapêutica ou prognóstico. Ao longo de nossa vida médica, ambos os tipos de questões estão presentes, variando na proporção em que nossa experiência aumenta à medida do tempo de prática clínica. O processo de encontrar resposta apropriada à dúvida surgida no atendimento depende da forma como estruturamos as partes deste processo. A forma preconizada é conhecida pela sigla PICO. formada por P de paciente ou população, I de intervenção ou indicador, C de comparação ou controle e O de "outcome", que na língua inglesa significa desfecho clínico, resultado, ou por fim, a resposta que se espera encontrar nas fontes de informação científica. Esta é a primeira condição básica para que a nossa busca possa ser bem sucedida, a segunda é encontrar as palavras-chaves que melhor descrevem cada uma destas quatro características da questão. Sem estes cuidados as pesquisas em bases de dados informatizadas costuma resultar em ausência de informação ou em quantidade muito grande de informação que não está relacionada com o nosso interesse.Clinical decisions in daily practice

  9. Engineering Analyses of NCSX Modular Coil and Its Supporting Structure for EM Loads

    International Nuclear Information System (INIS)

    Fan, H.M.; Williamson, D.

    2003-01-01

    NCSX modular coil is a major parts of the NCSX coil systems that surround the highly shaped plasma and vacuum vessel. The flexible copper cable conductors are used to form modular coil on both sides of the ''tee'' beam, which is cast inside the supporting shell structure. The Engineering analyses comprise sequentially coupled-field analyses that include an electromagnetic analysis to calculate the magnetic fields and EM forces, and a structural analysis to evaluate the structural responses. In the sequential EM-structural analysis, nodal forces obtained from the EM analysis were applied as ''nodal force'' loads in the subsequent stress analysis using the identical nodal points and elements. The shell model was imported directly from Pro/ENGINEER files in order to obtain an accurate structural representation. The Boolean operations provided by the ANSYS preprocessor were then applied to subdivide the solid model for more desirable finite element meshing. Material properties of the modular coil were based on test results. Analyses using the ANSYS program to evaluate structural responses of the complicated modular coil systems provided a clear understanding of the structural behaviors and the directions for improving the structural design

  10. <em>De novoem> prediction of structured RNAs from genomic sequences

    DEFF Research Database (Denmark)

    Gorodkin, Jan; Hofacker, Ivo L.; Þórarinsson, Elfar

    2010-01-01

    currently available, because evolutionary conservation highlights functionally important regions. Conserved secondary structure, rather than primary sequence, is the hallmark of many functionally important RNAs, because compensatory substitutions in base-paired regions preserve structure. Unfortunately...

  11. Cryo-EM Structure Determination Using Segmented Helical Image Reconstruction.

    Science.gov (United States)

    Fromm, S A; Sachse, C

    2016-01-01

    Treating helices as single-particle-like segments followed by helical image reconstruction has become the method of choice for high-resolution structure determination of well-ordered helical viruses as well as flexible filaments. In this review, we will illustrate how the combination of latest hardware developments with optimized image processing routines have led to a series of near-atomic resolution structures of helical assemblies. Originally, the treatment of helices as a sequence of segments followed by Fourier-Bessel reconstruction revealed the potential to determine near-atomic resolution structures from helical specimens. In the meantime, real-space image processing of helices in a stack of single particles was developed and enabled the structure determination of specimens that resisted classical Fourier helical reconstruction and also facilitated high-resolution structure determination. Despite the progress in real-space analysis, the combination of Fourier and real-space processing is still commonly used to better estimate the symmetry parameters as the imposition of the correct helical symmetry is essential for high-resolution structure determination. Recent hardware advancement by the introduction of direct electron detectors has significantly enhanced the image quality and together with improved image processing procedures has made segmented helical reconstruction a very productive cryo-EM structure determination method. © 2016 Elsevier Inc. All rights reserved.

  12. Online EM with weight-based forgetting

    OpenAIRE

    Celaya, Enric; Agostini, Alejandro

    2015-01-01

    In the on-line version of the EM algorithm introduced by Sato and Ishii (2000), a time-dependent discount factor is introduced for forgetting the effect of the old posterior values obtained with an earlier, inaccurate estimator. In their approach, forgetting is uniformly applied to the estimators of each mixture component depending exclusively on time, irrespective of the weight attributed to each unit for the observed sample. This causes an excessive forgetting in the less frequently sampled...

  13. Development of 101 Gene-based Single Nucleotide Polymorphism Markers in Sea Cucumber, <em>Apostichopus japonicusem>>

    Directory of Open Access Journals (Sweden)

    Wei Lu

    2012-06-01

    Full Text Available Single nucleotide polymorphisms (SNPs are currently the marker of choice in a variety of genetic studies. Using the high resolution melting (HRM genotyping approach, 101 gene-based SNP markers were developed for <em>Apostichopus japonicusem>, a sea cucumber species with economic significance for the aquaculture industry in East Asian countries. HRM analysis revealed that all the loci showed polymorphisms when evaluated using 40 <em>A. japonicusem> individuals collected from a natural population. The minor allele frequency ranged from 0.035 to 0.489. The observed and expected heterozygosities ranged from 0.050 to 0.833 and 0.073 to 0.907, respectively. Thirteen loci were found to depart significantly from Hardy–Weinberg equilibrium (HWE after Bonferroni corrections. Significant linkage disequilibrium (LD was detected in one pair of markers. These SNP markers are expected to be useful for future quantitative trait loci (QTL analysis, and to facilitate marker-assisted selection (MAS in <em>A. japonicusem>.

  14. Design bases - Concrete structures

    International Nuclear Information System (INIS)

    Diaz-Llanos Ros, M.

    1993-01-01

    The most suitable title for Section 2 is 'Design Bases', which covers not only calculation but also the following areas: - Structural design concepts. - Project criteria. - Material specifications. These concepts are developed in more detail in the following sections. The numbering in this document is neither complete nor hierarchical since, for easier cross referencing, it corresponds to the paragraphs of Eurocode 2 Part 1 (hereinafter 'EUR-2') which are commented on. (author)

  15. Solution NMR Structure of Hypothetical Protein CV_2116 Encoded by a Viral Prophage Element in <em>Chromobacterium violaceumem>

    Directory of Open Access Journals (Sweden)

    Yunhuang Yang

    2012-06-01

    Full Text Available CV_2116 is a small hypothetical protein of 82 amino acids from the Gram-negative coccobacillus <em>Chromobacterium violaceumem>. A PSI-BLAST search using the CV_2116 sequence as a query identified only one hit (E = 2e−07 corresponding to a hypothetical protein OR16_04617 from <em>Cupriavidus basilensisem> OR16, which failed to provide insight into the function of CV_2116. The <em>CV_2116em> gene was cloned into the p15TvLic expression plasmid, transformed into <em>E. coliem>, and 13C- and 15N-labeled NMR samples of CV_2116 were overexpressed in <em>E. coliem> and purified for structure determination using NMR spectroscopy. The resulting high-quality solution NMR structure of CV_2116 revealed a novel α + β fold containing two anti-parallel β -sheets in the <em>N>-terminal two-thirds of the protein and one α-helix in the <em>C>-terminal third of the protein. CV_2116 does not belong to any known protein sequence family and a Dali search indicated that no similar structures exist in the protein data bank. Although no function of CV_2116 could be derived from either sequence or structural similarity searches, the neighboring genes of <em>CV_2116em> encode various proteins annotated as similar to bacteriophage tail assembly proteins. Interestingly, <em>C. violaceumem> exhibits an extensive network of bacteriophage tail-like structures that likely result from lateral gene transfer by incorporation of viral DNA into its genome (prophages due to bacteriophage infection. Indeed, <em>C. violaceumem> has been shown to contain four prophage elements and <em>CV_2116em> resides in the fourth of these elements. Analysis of the putative operon in which CV_2116 resides indicates that CV_2116 might be a component of the bacteriophage tail-like assembly that occurs in <em>C. violaceumem>.

  16. Quantifying Golgi structure using EM: combining volume-SEM and stereology for higher throughput.

    Science.gov (United States)

    Ferguson, Sophie; Steyer, Anna M; Mayhew, Terry M; Schwab, Yannick; Lucocq, John Milton

    2017-06-01

    Investigating organelles such as the Golgi complex depends increasingly on high-throughput quantitative morphological analyses from multiple experimental or genetic conditions. Light microscopy (LM) has been an effective tool for screening but fails to reveal fine details of Golgi structures such as vesicles, tubules and cisternae. Electron microscopy (EM) has sufficient resolution but traditional transmission EM (TEM) methods are slow and inefficient. Newer volume scanning EM (volume-SEM) methods now have the potential to speed up 3D analysis by automated sectioning and imaging. However, they produce large arrays of sections and/or images, which require labour-intensive 3D reconstruction for quantitation on limited cell numbers. Here, we show that the information storage, digital waste and workload involved in using volume-SEM can be reduced substantially using sampling-based stereology. Using the Golgi as an example, we describe how Golgi populations can be sensed quantitatively using single random slices and how accurate quantitative structural data on Golgi organelles of individual cells can be obtained using only 5-10 sections/images taken from a volume-SEM series (thereby sensing population parameters and cell-cell variability). The approach will be useful in techniques such as correlative LM and EM (CLEM) where small samples of cells are treated and where there may be variable responses. For Golgi study, we outline a series of stereological estimators that are suited to these analyses and suggest workflows, which have the potential to enhance the speed and relevance of data acquisition in volume-SEM.

  17. Net Energy, CO2 Emission and Land-Based Cost-Benefit Analyses of <em>Jatropha> em>Biodiesel: A Case Study of the Panzhihua Region of Sichuan Province in China

    Directory of Open Access Journals (Sweden)

    Xiangzheng Deng

    2012-06-01

    Full Text Available Bioenergy is currently regarded as a renewable energy source with a high growth potential. Forest-based biodiesel, with the significant advantage of not competing with grain production on cultivated land, has been considered as a promising substitute for diesel fuel by many countries, including China. Consequently, extracting biodiesel from <em>Jatropha> curcasem> has become a growing industry. However, many key issues related to the development of this industry are still not fully resolved and the prospects for this industry are complicated. The aim of this paper is to evaluate the net energy, CO2 emission, and cost efficiency of <em>Jatropha> biodiesel as a substitute fuel in China to help resolve some of the key issues by studying data from this region of China that is well suited to growing <em>Jatropha>. Our results show that: (1 <em>Jatropha> biodiesel is preferable for global warming mitigation over diesel fuel in terms of the carbon sink during <em>Jatropha> tree growth. (2 The net energy yield of <em>Jatropha> biodiesel is much lower than that of fossil fuel, induced by the high energy consumption during <em>Jatropha> plantation establishment and the conversion from seed oil to diesel fuel step. Therefore, the energy efficiencies of the production of <em>Jatropha> and its conversion to biodiesel need to be improved. (3 Due to current low profit and high risk in the study area, farmers have little incentive to continue or increase <em>Jatropha> production. (4 It is necessary to provide more subsidies and preferential policies for <em>Jatropha> plantations if this industry is to grow. It is also necessary for local government to set realistic objectives and make rational plans to choose proper sites for <em>Jatropha> biodiesel development and the work reported here should assist that effort. Future research focused on breading high-yield varieties, development of efficient field

  18. A structural dynamic factor model for the effects of monetary policy estimated by the EM algorithm

    DEFF Research Database (Denmark)

    Bork, Lasse

    This paper applies the maximum likelihood based EM algorithm to a large-dimensional factor analysis of US monetary policy. Specifically, economy-wide effects of shocks to the US federal funds rate are estimated in a structural dynamic factor model in which 100+ US macroeconomic and financial time...... series are driven by the joint dynamics of the federal funds rate and a few correlated dynamic factors. This paper contains a number of methodological contributions to the existing literature on data-rich monetary policy analysis. Firstly, the identification scheme allows for correlated factor dynamics...... as opposed to the orthogonal factors resulting from the popular principal component approach to structural factor models. Correlated factors are economically more sensible and important for a richer monetary policy transmission mechanism. Secondly, I consider both static factor loadings as well as dynamic...

  19. Reliability based structural design

    NARCIS (Netherlands)

    Vrouwenvelder, A.C.W.M.

    2014-01-01

    According to ISO 2394, structures shall be designed, constructed and maintained in such a way that they are suited for their use during the design working life in an economic way. To fulfil this requirement one needs insight into the risk and reliability under expected and non-expected actions. A

  20. Structural variations of staphylococcal cassette chromosome <em>mec Tem>ype IVa in <em>Staphylococcus aureus em>clonal complex 8 and unrelated lineages

    DEFF Research Database (Denmark)

    Damborg, Peter Panduro; Bartels, Mette Damkjær; Boye, Kit

    2011-01-01

    PCR mapping of staphylococcal cassette chromosome mec type IVa and adjacent mobile elements in 94 methicillin-resistant Staphylococcus aureus (MRSA) strains identified two primary structures (A and B) that could be further classified into two (A1 and A2) and five (B1 to B5) variants, primarily...... based on structural differences in the orfX-J3 region. While spa type t008 (USA300) invariably contained the A variants, other spa types belonging to clonal complex 8 and unrelated lineages generally contained B variants. These findings have important implications for the typing and identification...

  1. Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases

    Science.gov (United States)

    Mazhab-Jafari, Mohammad T.; Rubinstein, John L.

    2016-01-01

    Electron cryomicroscopy (cryo-EM) has significantly advanced our understanding of molecular structure in biology. Recent innovations in both hardware and software have made cryo-EM a viable alternative for targets that are not amenable to x-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy. Cryo-EM has even become the method of choice in some situations where x-ray crystallography and NMR spectroscopy are possible but where cryo-EM can determine structures at higher resolution or with less time or effort. Rotary adenosine triphosphatases (ATPases) are crucial to the maintenance of cellular homeostasis. These enzymes couple the synthesis or hydrolysis of adenosine triphosphate to the use or production of a transmembrane electrochemical ion gradient, respectively. However, the membrane-embedded nature and conformational heterogeneity of intact rotary ATPases have prevented their high-resolution structural analysis to date. Recent application of cryo-EM methods to the different types of rotary ATPase has led to sudden advances in understanding the structure and function of these enzymes, revealing significant conformational heterogeneity and characteristic transmembrane α helices that are highly tilted with respect to the membrane. In this Review, we will discuss what has been learned recently about rotary ATPase structure and function, with a particular focus on the vacuolar-type ATPases. PMID:27532044

  2. Psiquiatria baseada em evidências Evidence-based psychiatry

    Directory of Open Access Journals (Sweden)

    Maurício S de Lima

    2000-09-01

    Full Text Available Em psiquiatria, observa-se grande variabilidade de práticas clínicas, muitas vezes desnecessária. Essas variações podem estar relacionadas à ausência de evidência científica confiável ou ao desconhecimento das evidências de boa qualidade disponíveis. A medicina baseada em evidências (MBE é uma combinação de estratégias que busca assegurar que o cuidado individual do paciente seja baseado na melhor informação disponível, a qual deve ser incorporada à prática clínica. Neste artigo, conceitos de MBE são discutidos com relação a aspectos e desafios no tratamento de pacientes com distimia, bulimia nervosa e esquizofrenia. A partir de resultados de três revisões sistemáticas recentemente publicadas, conclui-se que a prática de psiquiatria baseada em evidências acrescenta qualidade à prática psiquiátrica tradicional.The unnecessary variability often seen in the clinical practice can be related to both the absence of reliable evidence and unawareness of the existence of good quality evidence. Evidence-Based Medicine (EBM is a set of linked strategies designed to assist clinicians in keeping themselves up-to-date with the best available evidence. Such evidence must be incorporated into the clinical practice. EBM concepts are discussed here through common aspects and challenges doctors face when treating patients with dysthymia, bulimia nervosa, and schizophrenia. In the light of some results from three systematic reviews it is concluded that Evidence-Based Psychiatry strategies, rather than replacing the traditional ones, may be a valuable tool to improving quality in a good clinical practice.

  3. Structure-Based Turbulence Model

    National Research Council Canada - National Science Library

    Reynolds, W

    2000-01-01

    .... Maire carried out this work as part of his Phi) research. During the award period we began to explore ways to simplify the structure-based modeling so that it could be used in repetitive engineering calculations...

  4. Structure of <em>Salmonella typhimuriumem> OMP Synthase in a Complete Substrate Complex

    DEFF Research Database (Denmark)

    Grubmeyer, Charles; Hansen, Michael Riis; Fedorov, Alexander A.

    2012-01-01

    Dimeric Salmonella typhimurium orotate phosphoribosyltransferase (OMP synthase, EC 2.4.2.10), a key enzyme in de novo pyrimidine nucleotide synthesis, has been cocrystallized in a complete substrate E·MgPRPP·orotate complex and the structure determined to 2.2 Å resolution. This structure resem...

  5. Stabilization students' awareness based on training classes in EMS

    Directory of Open Access Journals (Sweden)

    Behzad Imani

    2013-05-01

    Full Text Available Introduction: The professional ethics in the medical field is an important concept. Understanding of EMS with professional ethic provide better services and to minimum professional stress. The group discussion method in the teaching of professional ethics is efficiency. The authors benefited of the method to evaluate the awareness of the ethical issues based on training classes.Material and Methods: The study was Cross - sectional. The study population included all of the students of EMS in the final year. Number of samples was 30 and method of sampling was the census method. After of expression course plan pre test was taken and after the end of class final examination was taken. Rate of knowledge of student was assessed after 3 semesters and data obtained were analyzed by software SPSS 16.Results: Rate of knowledge of students before teaching were 97% weak and 3% moderate. The scores of Students was between 20-14 and the mean of was 16.58. Results after 3 terms were this: The average student score 24/69, most samples (80% have a high awareness and 20% had poor knowledge.Conclusion: The ministry of health policy is edification prior knowledge. The students' awareness of duty was high (80%, in the legal field was very weak and in some areas, such as respect, altruism was moderate.

  6. CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast.

    Science.gov (United States)

    Nguyen, Thi Hoang Duong; Galej, Wojciech P; Fica, Sebastian M; Lin, Pei-Chun; Newman, Andrew J; Nagai, Kiyoshi

    2016-02-01

    The spliceosome is formed on pre-mRNA substrates from five small nuclear ribonucleoprotein particles (U1, U2, U4/U6 and U5 snRNPs), and numerous non-snRNP factors. Saccharomyces cerevisiae U4/U6.U5 tri-snRNP comprises U5 snRNA, U4/U6 snRNA duplex and approximately 30 proteins and represents a substantial part of the spliceosome before activation. Schizosaccharomyces pombe U2.U6.U5 spliceosomal complex is a post-catalytic intron lariat spliceosome containing U2 and U5 snRNPs, NTC (nineteen complex), NTC-related proteins (NTR), U6 snRNA, and an RNA intron lariat. Two recent papers describe near-complete atomic structures of these complexes based on cryoEM single-particle analysis. The U4/U6.U5 tri-snRNP structure provides crucial insight into the activation mechanism of the spliceosome. The U2.U6.U5 complex reveals the striking architecture of NTC and NTR and important features of the group II intron-like catalytic RNA core remaining after spliced mRNA is released. These two structures greatly advance our understanding of the mechanism of pre-mRNA splicing. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  7. Plasma-based accelerator structures

    International Nuclear Information System (INIS)

    Schroeder, Carl B.

    1999-01-01

    Plasma-based accelerators have the ability to sustain extremely large accelerating gradients, with possible high-energy physics applications. This dissertation further develops the theory of plasma-based accelerators by addressing three topics: the performance of a hollow plasma channel as an accelerating structure, the generation of ultrashort electron bunches, and the propagation of laser pulses is underdense plasmas

  8. Structure of the 30 kDa HIV-1 RNA Dimerization Signal by a Hybrid Cryo-EM, NMR, and Molecular Dynamics Approach.

    Science.gov (United States)

    Zhang, Kaiming; Keane, Sarah C; Su, Zhaoming; Irobalieva, Rossitza N; Chen, Muyuan; Van, Verna; Sciandra, Carly A; Marchant, Jan; Heng, Xiao; Schmid, Michael F; Case, David A; Ludtke, Steven J; Summers, Michael F; Chiu, Wah

    2018-03-06

    Cryoelectron microscopy (cryo-EM) and nuclear magnetic resonance (NMR) spectroscopy are routinely used to determine structures of macromolecules with molecular weights over 65 and under 25 kDa, respectively. We combined these techniques to study a 30 kDa HIV-1 dimer initiation site RNA ([DIS] 2 ; 47 nt/strand). A 9 Å cryo-EM map clearly shows major groove features of the double helix and a right-handed superhelical twist. Simulated cryo-EM maps generated from time-averaged molecular dynamics trajectories (10 ns) exhibited levels of detail similar to those in the experimental maps, suggesting internal structural flexibility limits the cryo-EM resolution. Simultaneous inclusion of the cryo-EM map and 2 H-edited NMR-derived distance restraints during structure refinement generates a structure consistent with both datasets and supporting a flipped-out base within a conserved purine-rich bulge. Our findings demonstrate the power of combining global and local structural information from these techniques for structure determination of modest-sized RNAs. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. Consumo de nutrientes em idosos residentes em Porto Alegre (RS, Brasil: um estudo de base populacional

    Directory of Open Access Journals (Sweden)

    Carina Duarte Venturini

    2015-12-01

    Full Text Available Resumo Para descrever o perfil de consumo de nutrientes e verificar a sua associação com as variáveis sociodemográficas e de saúde, desenvolveu-se um estudo transversal, de base populacional em uma amostra aleatória de 427 idosos residentes em Porto Alegre, Brasil. O consumo alimentar foi avaliado através do Inquérito Recordatório de 24 Horas e Investigação da História Dietética. Dos idosos entrevistados, 70% eram mulheres; 48,5% possuíam entre 60 e 69 anos; 68,8% possuíam menos de 8 anos de escolaridade; 39,0%, renda familiar entre 2 e 5 salários mínimos; e 58,4% não praticava exercício físico. A hipertensão foi a doença mais prevalente, e 54,9% dos idosos estavam abaixo do peso. Os homens consumiam mais calorias, proteínas, fibras, minerais e vitaminas do que as mulheres. O consumo de carboidrato e cálcio aumentou conforme o avanço da idade, assim como diminuiu a ingestão de zinco. A prática de exercício físico elevou o consumo de calorias, magnésio, potássio e fósforo. Quanto maior a escolaridade, maior é o consumo de vitaminas B6 e B12; quanto maior a renda familiar, maior o consumo de vitamina B6 e ácido fólico. Os resultados demonstram que há deficiências nutricionais na alimentação diária da nossa população de idosos, principalmente entre as mulheres e os indivíduos acima de 80 anos.

  10. Reliability Based Ship Structural Design

    DEFF Research Database (Denmark)

    Dogliani, M.; Østergaard, C.; Parmentier, G.

    1996-01-01

    This paper deals with the development of different methods that allow the reliability-based design of ship structures to be transferred from the area of research to the systematic application in current design. It summarises the achievements of a three-year collaborative research project dealing...... with developments of models of load effects and of structural collapse adopted in reliability formulations which aim at calibrating partial safety factors for ship structural design. New probabilistic models of still-water load effects are developed both for tankers and for containerships. New results are presented...... structure of several tankers and containerships. The results of the reliability analysis were the basis for the definition of a target safety level which was used to asses the partial safety factors suitable for in a new design rules format to be adopted in modern ship structural design. Finally...

  11. Sperm structure and sperm transfer in <em>Pseudopythina subsinuataem> (Bivalvia, Galeommatoidea)

    DEFF Research Database (Denmark)

    Jespersen, Åse

    2009-01-01

    to the elongate cells. Most females contain one to three "sperm trees", structures consisting of a short stem and numerous branches. They are firmly implanted in the abfrontal part of the gill filament and protrude into the posterior part of the suprabranchial (brooding) chamber. Implantation of the trees causes...... the gill tissue to swell around the stem and some of the nearest filaments to coalesce. All branches are densely coated with euspermatozoa that are attached by means of their acrosomes. It is conjectured that the syncytial and multinucleate trees arise from seminal receptacle cells that detach from...

  12. Structure and optics of the eyes of the box jellyfish <em>Chiropsella bronzieem>

    DEFF Research Database (Denmark)

    O’Connor, Megan; Garm, Anders Lydik; Nilsson, Dan-E.

    2009-01-01

    Cubomedusae have a total of 24 eyes of four morphologically different types. Two of these eye types are camera-type eyes (upper and lower lens-eye), while the other two eye types are simpler pigment pit eyes (pit and slit eye). Here, we give a description of the visual system of the box jellyfish...... those in the previously investigated species Tripedalia cystophora. In the lower lens-eye of C. bronzie, blur circles subtend 20 and 52° for closed and open pupil, respectively, effectively removing all but the coarsest structures of the image. Histology reveals that the retina of the lower lens...

  13. Accelerated EM-based clustering of large data sets

    NARCIS (Netherlands)

    Verbeek, J.J.; Nunnink, J.R.J.; Vlassis, N.

    2006-01-01

    Motivated by the poor performance (linear complexity) of the EM algorithm in clustering large data sets, and inspired by the successful accelerated versions of related algorithms like k-means, we derive an accelerated variant of the EM algorithm for Gaussian mixtures that: (1) offers speedups that

  14. RBI - Risk Based Inspection: new concept applied to management of FPSOs (Floating, Production and Storage Offshore) structural integrity; IBR-Inspecao baseada em risco: um novo conceito aplicado a gestao da integridade estrutural de FPSOs

    Energy Technology Data Exchange (ETDEWEB)

    Farias, Bruno de; Figueiredo, Eduardo; Luiz, Marcio [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil); Meurer, Gustavo; Duarte, Romulo; Belligotti, Rufo; Krzonkalla, Viviane [ABS Consulting, Rio de Janeiro, RJ (Brazil)

    2008-07-01

    Due to the difficulties of adapting the plan of inspection, typical of oil tankers, the units of the FPSO, began to occur large periods of unavailability of the cargo tanks. Also, with the expansion of the fleet, began to notice a difficulty in meeting the plan of inspection of the FPSO's hull. To improve the management of structural integrity of its FPSO's, PETROBRAS aims to ABS Consulting with the development and implementation of Risk-Based Inspection, known as RBI. This concept is applicable to various branches of industry. The companies began their implementation of oil by refineries. The development application for a ship's hull is recent and PETROBRAS is one of the first companies to implement the IBR for monitoring of the FPSO hull. (author)

  15. Value-based <em>Q(s,S) em>policy for joint replenishments

    DEFF Research Database (Denmark)

    Johansen, Søren Glud; Thorstenson, Anders

    replenishment order is issued, if the expected cost of ordering immediately according to the (s, S) policy is less than the expected cost of deferring the order until the next demand or until the level Q is reached. We use simulation to evaluate our policy. Applying the value-based Q(s, S) policy to a standard...... set of 12-item numerical examples from the literature, the long-run average cost of the best known solution is reduced by approximately 1%. Further examples are also investigated and in some cases for which the cost structure implies a high service level, the cost reduction exceeds 10% of the cost...

  16. Efficient approach to simulate EM loads on massive structures in ITER machine

    Energy Technology Data Exchange (ETDEWEB)

    Alekseev, A. [ITER Organization, Route de Vinon sur Verdon, 13115 St. Paul-Lez-Durance (France); Andreeva, Z.; Belov, A.; Belyakov, V.; Filatov, O. [D.V. Efremov Scientific Research Institute, 196641 St. Petersburg (Russian Federation); Gribov, Yu.; Ioki, K. [ITER Organization, Route de Vinon sur Verdon, 13115 St. Paul-Lez-Durance (France); Kukhtin, V.; Labusov, A.; Lamzin, E.; Lyublin, B.; Malkov, A.; Mazul, I. [D.V. Efremov Scientific Research Institute, 196641 St. Petersburg (Russian Federation); Rozov, V.; Sugihara, M. [ITER Organization, Route de Vinon sur Verdon, 13115 St. Paul-Lez-Durance (France); Sychevsky, S., E-mail: sytch@sintez.niiefa.spb.su [D.V. Efremov Scientific Research Institute, 196641 St. Petersburg (Russian Federation)

    2013-10-15

    Highlights: ► A modelling technique to predict EM loads in ITER conducting structures is presented. ► The technique provides low computational cost and parallel computations. ► Detailed models were built for the system “vacuum vessel, cryostat, thermal shields”. ► EM loads on massive in-vessel structures were simulated with the use of local models. ► A flexible combination of models enables desired accuracy of load distributions. -- Abstract: Operation of the ITER machine is associated with high electromagnetic (EM) loads. An essential contributor to EM loads is eddy currents induced in passive conductive structures. Reasoning from the ITER construction, a modelling technique has been developed and applied in computations to efficiently predict anticipated loads. The technique allows us to avoid building a global 3D finite-element (FE) model that requires meshing of the conducting structures and their vacuum environment into 3D solid elements that leads to high computational cost. The key features of the proposed technique are: (i) the use of an existing shell model for the system “vacuum vessel (VV), cryostat, and thermal shields (TS)” implementing the magnetic shell approach. A solution is obtained in terms of a single-component, in this case, vector electric potential taken within the conducting shells of the “VV + cryostat + TS” system. (ii) EM loads on in-vessel conducting structures are simulated with the use of local FE models. The local models use either the 3D solid body or shell approximations. Reasoning from the simulation efficiency, the local boundary conditions are put with respect to the total field or an external field. The use of an integral-differential formulation and special procedures ensures smooth and accurate simulated distributions of fields from current sources of any geometry. The local FE models have been developed and applied for EM analyses of a variety of the ITER components including the diagnostic systems

  17. STRUCTURAL ANNOTATION OF EM IMAGES BY GRAPH CUT

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Hang; Auer, Manfred; Parvin, Bahram

    2009-05-08

    Biological images have the potential to reveal complex signatures that may not be amenable to morphological modeling in terms of shape, location, texture, and color. An effective analytical method is to characterize the composition of a specimen based on user-defined patterns of texture and contrast formation. However, such a simple requirement demands an improved model for stability and robustness. Here, an interactive computational model is introduced for learning patterns of interest by example. The learned patterns bound an active contour model in which the traditional gradient descent optimization is replaced by the more efficient optimization of the graph cut methods. First, the energy function is defined according to the curve evolution. Next, a graph is constructed with weighted edges on the energy function and is optimized with the graph cut algorithm. As a result, the method combines the advantages of the level set method and graph cut algorithm, i.e.,"topological" invariance and computational efficiency. The technique is extended to the multi-phase segmentation problem; the method is validated on synthetic images and then applied to specimens imaged by transmission electron microscopy(TEM).

  18. Computational Prediction of Atomic Structures of Helical Membrane Proteins Aided by EM Maps

    Science.gov (United States)

    Kovacs, Julio A.; Yeager, Mark; Abagyan, Ruben

    2007-01-01

    Integral membrane proteins pose a major challenge for protein-structure prediction because only ≈100 high-resolution structures are available currently, thereby impeding the development of rules or empirical potentials to predict the packing of transmembrane α-helices. However, when an intermediate-resolution electron microscopy (EM) map is available, it can be used to provide restraints which, in combination with a suitable computational protocol, make structure prediction feasible. In this work we present such a protocol, which proceeds in three stages: 1), generation of an ensemble of α-helices by flexible fitting into each of the density rods in the low-resolution EM map, spanning a range of rotational angles around the main helical axes and translational shifts along the density rods; 2), fast optimization of side chains and scoring of the resulting conformations; and 3), refinement of the lowest-scoring conformations with internal coordinate mechanics, by optimizing the van der Waals, electrostatics, hydrogen bonding, torsional, and solvation energy contributions. In addition, our method implements a penalty term through a so-called tethering map, derived from the EM map, which restrains the positions of the α-helices. The protocol was validated on three test cases: GpA, KcsA, and MscL. PMID:17496035

  19. Grouped fuzzy SVM with EM-based partition of sample space for clustered microcalcification detection.

    Science.gov (United States)

    Wang, Huiya; Feng, Jun; Wang, Hongyu

    2017-07-20

    Detection of clustered microcalcification (MC) from mammograms plays essential roles in computer-aided diagnosis for early stage breast cancer. To tackle problems associated with the diversity of data structures of MC lesions and the variability of normal breast tissues, multi-pattern sample space learning is required. In this paper, a novel grouped fuzzy Support Vector Machine (SVM) algorithm with sample space partition based on Expectation-Maximization (EM) (called G-FSVM) is proposed for clustered MC detection. The diversified pattern of training data is partitioned into several groups based on EM algorithm. Then a series of fuzzy SVM are integrated for classification with each group of samples from the MC lesions and normal breast tissues. From DDSM database, a total of 1,064 suspicious regions are selected from 239 mammography, and the measurement of Accuracy, True Positive Rate (TPR), False Positive Rate (FPR) and EVL = TPR* 1-FPR are 0.82, 0.78, 0.14 and 0.72, respectively. The proposed method incorporates the merits of fuzzy SVM and multi-pattern sample space learning, decomposing the MC detection problem into serial simple two-class classification. Experimental results from synthetic data and DDSM database demonstrate that our integrated classification framework reduces the false positive rate significantly while maintaining the true positive rate.

  20. Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.

    Science.gov (United States)

    Rawson, Shaun; Bisson, Claudine; Hurdiss, Daniel L; Fazal, Asif; McPhillie, Martin J; Sedelnikova, Svetlana E; Baker, Patrick J; Rice, David W; Muench, Stephen P

    2018-02-20

    Histidine biosynthesis is an essential process in plants and microorganisms, making it an attractive target for the development of herbicides and antibacterial agents. Imidazoleglycerol-phosphate dehydratase (IGPD), a key enzyme within this pathway, has been biochemically characterized in both Saccharomyces cerevisiae ( Sc_ IGPD) and Arabidopsis thaliana ( At_ IGPD). The plant enzyme, having been the focus of in-depth structural analysis as part of an inhibitor development program, has revealed details about the reaction mechanism of IGPD, whereas the yeast enzyme has proven intractable to crystallography studies. The structure-activity relationship of potent triazole-phosphonate inhibitors of IGPD has been determined in both homologs, revealing that the lead inhibitor (C348) is an order of magnitude more potent against Sc_ IGPD than At_ IGPD; however, the molecular basis of this difference has not been established. Here we have used single-particle electron microscopy (EM) to study structural differences between the At and Sc_ IGPD homologs, which could influence the difference in inhibitor potency. The resulting EM maps at ∼3 Å are sufficient to de novo build the protein structure and identify the inhibitor binding site, which has been validated against the crystal structure of the At_ IGPD/C348 complex. The structure of Sc _IGPD reveals that a 24-amino acid insertion forms an extended loop region on the enzyme surface that lies adjacent to the active site, forming interactions with the substrate/inhibitor binding loop that may influence inhibitor potency. Overall, this study provides insights into the IGPD family and demonstrates the power of using an EM approach to study inhibitor binding. Copyright © 2018 the Author(s). Published by PNAS.

  1. <em>N>-Substituted 5-Chloro-6-phenylpyridazin-3(2<em>H>-ones: Synthesis, Insecticidal Activity Against <em>Plutella xylostella em>(L. and SAR Study

    Directory of Open Access Journals (Sweden)

    Song Yang

    2012-08-01

    Full Text Available A series of <em>N>-substituted 5-chloro-6-phenylpyridazin-3(2<em>H>-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for <em>in vitroem> insecticidal activity against <em>Plutella xylostellaem>. The results showed that the synthesized pyridazin-3(2<em>H>-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR for these compounds were also discussed.

  2. Cryo-EM image alignment based on nonuniform fast Fourier transform.

    Science.gov (United States)

    Yang, Zhengfan; Penczek, Pawel A

    2008-08-01

    In single particle analysis, two-dimensional (2-D) alignment is a fundamental step intended to put into register various particle projections of biological macromolecules collected at the electron microscope. The efficiency and quality of three-dimensional (3-D) structure reconstruction largely depends on the computational speed and alignment accuracy of this crucial step. In order to improve the performance of alignment, we introduce a new method that takes advantage of the highly accurate interpolation scheme based on the gridding method, a version of the nonuniform fast Fourier transform, and utilizes a multi-dimensional optimization algorithm for the refinement of the orientation parameters. Using simulated data, we demonstrate that by using less than half of the sample points and taking twice the runtime, our new 2-D alignment method achieves dramatically better alignment accuracy than that based on quadratic interpolation. We also apply our method to image to volume registration, the key step in the single particle EM structure refinement protocol. We find that in this case the accuracy of the method not only surpasses the accuracy of the commonly used real-space implementation, but results are achieved in much shorter time, making gridding-based alignment a perfect candidate for efficient structure determination in single particle analysis.

  3. Cryo-EM image alignment based on nonuniform fast Fourier transform

    International Nuclear Information System (INIS)

    Yang Zhengfan; Penczek, Pawel A.

    2008-01-01

    In single particle analysis, two-dimensional (2-D) alignment is a fundamental step intended to put into register various particle projections of biological macromolecules collected at the electron microscope. The efficiency and quality of three-dimensional (3-D) structure reconstruction largely depends on the computational speed and alignment accuracy of this crucial step. In order to improve the performance of alignment, we introduce a new method that takes advantage of the highly accurate interpolation scheme based on the gridding method, a version of the nonuniform fast Fourier transform, and utilizes a multi-dimensional optimization algorithm for the refinement of the orientation parameters. Using simulated data, we demonstrate that by using less than half of the sample points and taking twice the runtime, our new 2-D alignment method achieves dramatically better alignment accuracy than that based on quadratic interpolation. We also apply our method to image to volume registration, the key step in the single particle EM structure refinement protocol. We find that in this case the accuracy of the method not only surpasses the accuracy of the commonly used real-space implementation, but results are achieved in much shorter time, making gridding-based alignment a perfect candidate for efficient structure determination in single particle analysis

  4. Vibration-based structural health monitoring of harbor caisson structure

    Science.gov (United States)

    Lee, So-Young; Lee, So-Ra; Kim, Jeong-Tae

    2011-04-01

    This study presents vibration-based structural health monitoring method in foundation-structure interface of harbor caisson structure. In order to achieve the objective, the following approaches are implemented. Firstly, vibration-based response analysis method is selected and structural health monitoring (SHM) technique is designed for harbor caisson structure. Secondly, the performance of designed SHM technique for harbor structure is examined by FE analysis. Finally, the applicability of designed SHM technique for harbor structure is evaluated by dynamic tests on a lab-scaled caisson structure.

  5. A New Natural Lactone from <em>Dimocarpus> <em>longan> Lour. Seeds

    Directory of Open Access Journals (Sweden)

    Zhongjun Li

    2012-08-01

    Full Text Available A new natural product named longanlactone was isolated from <em>Dimocarpus> <em>longan> Lour. seeds. Its structure was determined as 3-(2-acetyl-1<em>H>-pyrrol-1-yl-5-(prop-2-yn-1-yldihydrofuran-2(3H-one by spectroscopic methods and HRESIMS.

  6. Structural model and <em>trans>-interaction of the entire ectodomain of the olfactory cell adhesion molecule

    DEFF Research Database (Denmark)

    Kulahin, Nikolaj; Kristensen, Ole; Rasmussen, Kim K

    2011-01-01

    of six recombinant proteins corresponding to different regions of the ectodomain. The model is the longest experimentally based composite structural model of an entire IgCAM ectodomain. It displays an essentially linear arrangement of IgI-V, followed by bends between IgV and Fn3I and between Fn3I and Fn3...

  7. The Complete Mitochondrial Genome of the Pink Stem Borer, <em>Sesamia inferensem>, in Comparison with Four Other Noctuid Moths

    Directory of Open Access Journals (Sweden)

    Yu-Zhou Du

    2012-08-01

    Full Text Available The complete 15,413-bp mitochondrial genome (mitogenome of <em>Sesamia inferensem> (Walker (Lepidoptera: Noctuidae was sequenced and compared with those of four other noctuid moths. All of the mitogenomes analyzed displayed similar characteristics with respect to gene content, genome organization, nucleotide comparison, and codon usages. Twelve-one protein-coding genes (PCGs utilized the standard ATN, but the <em>cox1 em>gene used CGA as the initiation codon; <em>cox1em>, <em>cox2em>, and <em>nad4em> genes had the truncated termination codon T in the <em>S. inferens em>mitogenome. All of the tRNA genes had typical cloverleaf secondary structures except for <em>trnS1(AGNem>, in which the dihydrouridine (DHU arm did not form a stable stem-loop structure. Both the secondary structures of <em>rrnL> and <em>rrnS> genes inferred from the <em>S. inferens em>mitogenome closely resembled those of other noctuid moths. In the A+T-rich region, the conserved motif “ATAGA” followed by a long T-stretch was observed in all noctuid moths, but other specific tandem-repeat elements were more variable. Additionally, the <em>S. inferens em>mitogenome contained a potential stem-loop structure, a duplicated 17-bp repeat element, a decuplicated segment, and a microsatellite “(AT7”, without a poly-A element upstream of the<em> trnM em>in the A+T-rich region. Finally, the phylogenetic relationships were reconstructed based on amino acid sequences of mitochondrial 13 PCGs, which support the traditional morphologically based view of relationships within the Noctuidae.

  8. THE SYLLABLE STRUCTURE IN EUROPEAN PORTUGUESE A Estrutura da Sílaba em Português Europeu

    Directory of Open Access Journals (Sweden)

    Maria Helena Mateus

    1998-02-01

    Full Text Available The goal of this paper is to discuss the internal structure of the syllable in European Portuguese and to propose an algorithm for base syllabification. Due to the analysis of consonant clusters in onset position and the occurrence of epenthetic vowels, and considering the variation of the vowels in word initial position that occupy the syllable nucleus without an onset at the phonetic level, we assume that, in European Portuguese, the syllable is always constituted by an onset and a rhyme even though one of these constituents (but not both may be empty, that is, one of then may have no phonetic realisation.O objetivo deste artigo é o de discutir a estrutura interna da sílaba em Português Europeu e o de propor um algoritmo para a silabificação de base. Tendo en conta a análise dos grupos de consoantes que ocupam o lugar de ataque e a possibilidade de existência de vogais epentéticas que desfazem alguns desses grupos, e considerando, ainda, a variação de vogais em posição inicial de palavra que constituem núcleo de sílaba sem ataque no nível fonético, apresenta-se a hipótese de que a sílaba, em Português Europeu, é sempre constituída por um ataque e por uma rima, mesmo que um desses constituintes (mas não os dois seja vazio. Ou seja, um dos dois constituintes pode não ter realização fonética.

  9. Consumo de nutrientes em adultos e idosos em estudo de base populacional: Projeto Bambuí

    Directory of Open Access Journals (Sweden)

    Aline Cristine Souza Lopes

    Full Text Available Inquérito alimentar populacional em amostra aleatória de 550 indivíduos > ou = 18 anos, realizado em Bambuí, Minas Gerais, Brasil, utilizando o Questionário Semiquantitativo de Freqüência Alimentar e recordatório 24 horas calibrados pela técnica de regressão linear. A análise constou de comparação de médias, teste de qui-quadrado e razão de adequação do nutriente (RAN-adequada: 90,0-110,0%. Foi baixo o percentual da população que apresentou RAN de acordo com o recomendado para consumo de carboidratos (2,4%, proteínas (17,6%, vitaminas (0,0-5,1% e minerais (0-21,1%. Diferenças de acordo com sexo e idade foram encontradas: 90,2% e 91,8% de mulheres apresentaram baixo consumo de ferro e vitamina B6, respectivamente. Ao contrário, 87,7% dos homens relataram consumo excessivo de ferro, 80,3% de fósforo e 11,9% de colesterol. Quanto à idade, 64,3% de idosos (> 60 anos relataram baixa ingestão protéica e 39,3% apresentavam inadequação das frações lipídicas; sendo que 35,7% informaram consumo excessivo de ácidos graxos saturados. Dos adultos (18-59 anos, 67,8% relataram excessivo consumo protéico e 53,4% ingestão insuficiente de ferro. Alto e inadequado consumo de lipídios e baixa ingestão de fibras, vitaminas e minerais, constituem problema importante de saúde pública por possivelmente contribuir para o aumento das doenças crônicas não transmissíveis.

  10. Reliability-Based Optimization in Structural Engineering

    DEFF Research Database (Denmark)

    Enevoldsen, I.; Sørensen, John Dalsgaard

    1994-01-01

    In this paper reliability-based optimization problems in structural engineering are formulated on the basis of the classical decision theory. Several formulations are presented: Reliability-based optimal design of structural systems with component or systems reliability constraints, reliability...

  11. Cryo-EM Structure of the TOM Core Complex from Neurospora crassa.

    Science.gov (United States)

    Bausewein, Thomas; Mills, Deryck J; Langer, Julian D; Nitschke, Beate; Nussberger, Stephan; Kühlbrandt, Werner

    2017-08-10

    The TOM complex is the main entry gate for protein precursors from the cytosol into mitochondria. We have determined the structure of the TOM core complex by cryoelectron microscopy (cryo-EM). The complex is a 148 kDa symmetrical dimer of ten membrane protein subunits that create a shallow funnel on the cytoplasmic membrane surface. In the core of the dimer, the β-barrels of the Tom40 pore form two identical preprotein conduits. Each Tom40 pore is surrounded by the transmembrane segments of the α-helical subunits Tom5, Tom6, and Tom7. Tom22, the central preprotein receptor, connects the two Tom40 pores at the dimer interface. Our structure offers detailed insights into the molecular architecture of the mitochondrial preprotein import machinery. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Estudo experimental comparativo entre diferentes curativosa à base de heparina em queimaduras de 2° grau em ratos

    Directory of Open Access Journals (Sweden)

    Thiago da Silva Cornelio

    2015-10-01

    Full Text Available Queimaduras pemanecem como um importante problema de saúde publica, complexo d oneroso ao sistema; demandando internações prolongadas, múltiplos procedimentos cirúrgicos, fármacos e curativos. Um dos curativos utlizados em queimados é a Heparina sódica tópica. Diversos autores estudaram o efeito da heparina sódica nas lesões térmicas e verificaram alteração favorável em animais que receberam heparina sódica também demonstrando efeitos favoráveis em seres humanos. O presente estudo duplo cego avaliou histopatológicamente queimaduras de pequena extensão e espessura parcial em ratos tratados com curativos à base de dois tipos de Heparina sódica aplicados de forma tópica, ALIMAX®, cujo uso recomendado é de forma tópica, e HEMOFOL®, cujo uso recomendado é de forma endovenosa, com o objetivo de comparar os benefícios, facilidades e custo dessa forma de tratamento. Materiais e Médotos: Utilizou-se 30 ratos Wistar, divididos em grupos e tratados com soro fisiológico, ALIMAX® e HEMOFOL®. Os ratos foram sacrificados nos dias 1°,2°,4°,7°,10°,11°,12°,15°,17°,20° e a área queimada analisada histopatológicamente, sem o conhecimento de qual fármaco foi utilizado nas amostras. Os criterios de avaliação foram: epitelização; extensão da área queimada; infiltrado inflamatório crônico; neoformação vascular; proliferação fibroblástica; leucócitos e reação gigantocelular e colágeno jovem. Resultados: A análise estatística mostrou significância (p0.05 entre o uso de ALIMAX® e HEMOFOL®, o que mostra que todos os animais tiveram lesões semelhantes frente a queimadura, sendo aqueles tratados com ambas as apresentações de heparina obtiveram um melhor desenvolvimento cicatricial em relação ao controle porém com benefícios identicos entre si. Conclusão: O uso topico de heparina sódica indicada para uso endovenoso(HEMOFOL®, apresenta os mesmos resultados que sua versão propriamente t

  13. Ultrastructure and LSU rDNA-based phylogeny of <em>Peridinium lomnickiiem> and description of <em>Chimonodinium> gen. nov. (Dinophyceae)

    DEFF Research Database (Denmark)

    Craveiro, Sandra C.; Calado, António J.; Daugbjerg, Niels

    2011-01-01

    Several populations of Peridinium lomnickii were examined by SEM and serial section TEM. Comparison with typical Peridinium, Peridiniopsis, Palatinus and Scrippsiella species revealed significant structural differences, congruent with phylogenetic hypotheses derived from partial LSU rDNA sequence...

  14. Specific PCR-based detection of <em>Alternaria helianthiem>

    DEFF Research Database (Denmark)

    Udayashankar, A.C.; Nayaka, S. Chandra; Archana, B.

    2012-01-01

    Alternaria helianthi is an important seed-borne pathogenic fungus responsible for blight disease in sunflower. The current detection methods, which are based on culture and morphological identification, are time-consuming, laborious and are not always reliable. A PCR-based diagnostic method...... tested. The detection limit of the PCR method was of 10 pg from template DNA. The primers could also detect the pathogen in infected sunflower seed. This species-specific PCR method provides a quick, simple, powerful and reliable alternative to conventional methods in the detection and identification...

  15. Estratégia e estrutura: em busca do alinhamento organizacional em um clube social esportivo Strategy and structure: the quest for organizational alignment in a social sports club

    Directory of Open Access Journals (Sweden)

    Augusto de Toledo Cruz Junior

    2005-12-01

    Full Text Available A literatura descreve tipologias de formas organizações, que podem ser divididas em organização baseada em trabalho e organização baseada em conhecimento. A forma de representação mais utilizada é o organograma. Contudo, esta forma de representação não consegue ilustrar adequadamente a dinâmica de funcionamento da organização, sobretudo em organizações em que o conhecimento e a experiência são os ativos-chave. Com o objetivo de investigar o processo de alinhamento entre estratégia e estrutura, a abordagem metodológica adotada foi a pesquisa-ação. A pesquisa foi realizada ao longo de 6 meses, no período dos anos 2003 e 2004, em um clube situado na cidade de São Paulo. Participaram da pesquisa um grupo de 12 gerentes, 10 supervisores, 9 coordenadores e 5 dos principais diretores. Este artigo mostra como um clube de atividades sociais, culturais e esportivas projetou sua estrutura organizacional alinhada à formação de competências e às suas dinâmicas de funcionamento, para operar com características de uma organização baseada em conhecimento. A nova forma de representação da estrutura organizacional, denominada organigraph, ajudou o clube a explicitar a estratégia emergente, para operar em um mercado competitivo turbulento e implementá-la como regra simples a ser seguida por todos. Além disto, é apresentado um modelo de avaliação do desempenho derivado de um organigraph.The academic and practical literature describes organizational typologies that can be classified according to two main categories: job-based and knowledge-based organizations. The organizational structure is most commonly represented or described by the organizational chart. However, this form of representation fails to adequately depict the organization's work dynamics, above all in companies whose key assets are knowledge and experience. To investigate the alignment between strategy and structure, the methodological approach adopted here

  16. Reliability-based optimization of engineering structures

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    2008-01-01

    The theoretical basis for reliability-based structural optimization within the framework of Bayesian statistical decision theory is briefly described. Reliability-based cost benefit problems are formulated and exemplitied with structural optimization. The basic reliability-based optimization...... problems are generalized to the following extensions: interactive optimization, inspection and repair costs, systematic reconstruction, re-assessment of existing structures. Illustrative examples are presented including a simple introductory example, a decision problem related to bridge re...

  17. Primed for Discovery: Atomic-Resolution Cryo-EM Structure of a Reovirus Entry Intermediate

    Directory of Open Access Journals (Sweden)

    Shane D. Trask

    2010-06-01

    Full Text Available A recently solved structure of the aquareovirus virion (Zhang, X; Jin, L.; Fang, Q; Hui, W.H.; Zhou Z.H. 3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry. Cell 2010, 141, 472-482 [1] provides new insights into the order of entry events, as well as confirming and refining several aspects of the entry mechanism, for aquareovirus and the related orthoreovirus. In particular, the structure provides evidence of a defined order for the progressive proteolytic cleavages of myristoylated penetration protein VP5 that prime the virion for membrane penetration. These observations reinforce the concept that, much like enveloped viruses, nonenveloped virions often undergo priming events that lead to a meta-stable state, preparing the virus for membrane penetration under the appropriate circumstances. In addition, this and other recent studies highlight the increasing power of electron cryomicroscopy to analyze large, geometrically regular structures, such as icosahedral viruses, at atomic resolution.

  18. Cryo-EM structure of isomeric molluscan hemocyanin triggered by viral infection.

    Directory of Open Access Journals (Sweden)

    Hongtao Zhu

    Full Text Available Hemocyanins (Hcs of arthropods and mollusks function not only as oxygen transporters, but also as phenoloxidases (POs. In invertebrates, PO is an important component in the innate immune cascade, where it functions as the initiator of melanin synthesis, a pigment involved in encapsulating and killing of pathogenic microbes. Although structures of Hc from several species of invertebrates have been reported, the structural basis for how PO activity is triggered by structural changes of Hc in vivo remains poorly understood. Here, we report a 6.8 Å cryo-electron microscopy (cryo-EM structure of the isomeric form of hemocyanin, which was isolated from Abalone Shriveling syndrome-associated Virus (AbSV infected abalone (Halitotis diversicolor, and build a pseudoatomic model of isomeric H. diversicolor hemocyanin 1 (HdH1. Our results show that, compared with native form of HdH1, the architecture of isomeric HdH1 turns into a more relaxed form. The interactions between certain functional units (FUs present in the native form of Hc either decreased or were totally abolished in the isomeric form of Hc. As a result of that, native state Hc switches to its isomeric form, enabling it to play its role in innate immune responses against invading pathogens.

  19. Controlling for <em>false negativesem> in agent-based models

    DEFF Research Database (Denmark)

    Secchi, Davide; Seri, Raffaello

    2017-01-01

    This article is concerned with the study of statistical power in agent-based modeling (ABM). After an overview of classic statistics theory on how to interpret Type-II error (whose occurrence is also referred to as a false negative) and power, the manuscript presents a study on ABM simulation art...... of simulation runs to reach an appropriate level of power. The study concludes with the importance for organizational behavior scholars to perform their models in an attempt to reach a power of 0.95 or higher at the 0.01 significance level....

  20. Cultivo de Oncidium baueri Lindley (Orchidaceae) em substratos a base de coco

    OpenAIRE

    Assis,Adriane Marinho de; Faria,Ricardo Tadeu de; Unemoto,Lilian Keiko; Colombo,Larissa Abgariani

    2008-01-01

    Entre os substratos utilizados no cultivo de orquídeas, a fibra de coco vem se destacando como promissor substituto do xaxim, material utilizado por muitos produtores e colecionadores de orquídeas, porém ameaçado de extinção. Objetivou-se, neste trabalho, foi avaliar a eficiência de substratos à base de coco, no cultivo da orquídea Oncidium baueri. As mudas foram cultivadas em vasos de polipropileno, permanecendo em viveiro com 50% de luminosidade. Os tratamentos constituíram-se de xaxim desf...

  1. Pigmentantes naturais em rações à base de sorgo para codornas japonesas em postura Natural pigments on sorghum-based rations for laying Japanese quails

    Directory of Open Access Journals (Sweden)

    Adolpho Marlon Antoniol de Moura

    2011-11-01

    Full Text Available Esta pesquisa foi realizada para avaliar os efeitos do uso de pigmentantes naturais e extratos de marigold e páprica em rações à base de sorgo para codornas japonesas. Foram utilizadas 180 codornas japonesas (Coturnix japonica, com 98 dias de idade, distribuídas em delineamento inteiramente casualizado em esquema de parcelas subdivididas, composto por cinco tratamentos e seis repetições com seis aves cada. O experimento foi dividido em seis períodos de quatro dias, totalizando 24 dias. Foram analisados o desempenho produtivo e a qualidade dos ovos das codornas. A cor da gema foi avaliada a cada quatro dias durante 24 dias pelo método do escore colorimétrico DSM. Não houve efeito dos tratamentos sobre o desempenho e a qualidade dos ovos das codornas, à exceção da cor da gema. O extrato de marigold proporcionou escore colorimétrico da gema equivalente ao das aves alimentadas com milho. A suplementação associada dos extratos de marigold e páprica proporcionou maior escore colorimétrico e em menor tempo. A utilização de pigmentantes naturais deve ser analisada considerando o escore colorimétrico que se deseja obter e o custo da suplementação de cada fonte comercial.The objective was to evaluate the effects of natural pigments from marigold extract and paprika to Japanese quails fed sorghum-based diets. One hundred and eight Japanese quails (Coturnix japonica, with 98 days of age were distributed in a complete randomized design in a split plot arrangement, with five treatments and six replicates of six birds each. The experiment was divided into six periods of four days each, totaling 24 days. Parameters productive performance and quail egg quality were evaluated. Yolk color was evaluated every 4 days for 24 days by the DSM colorimetric score method. There was no effect of experimental diets on performance or quality of quail egg, except for egg yolk color. The extract of marigold promoted yolk color scores equivalent to those

  2. Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.

    Science.gov (United States)

    Zhou, Xiaoyuan; Li, Minghui; Su, Deyuan; Jia, Qi; Li, Huan; Li, Xueming; Yang, Jian

    2017-12-01

    TRPML3 channels are mainly localized to endolysosomes and play a critical role in the endocytic pathway. Their dysfunction causes deafness and pigmentation defects in mice. TRPML3 activity is inhibited by low endolysosomal pH. Here we present cryo-electron microscopy (cryo-EM) structures of human TRPML3 in the closed, agonist-activated, and low-pH-inhibited states, with resolutions of 4.06, 3.62, and 4.65 Å, respectively. The agonist ML-SA1 lodges between S5 and S6 and opens an S6 gate. A polycystin-mucolipin domain (PMD) forms a luminal cap. S1 extends into this cap, forming a 'gating rod' that connects directly to a luminal pore loop, which undergoes dramatic conformational changes in response to low pH. S2 extends intracellularly and interacts with several intracellular regions to form a 'gating knob'. These unique structural features, combined with the results of electrophysiological studies, indicate a new mechanism by which luminal pH and other physiological modulators such as PIP 2 regulate TRPML3 by changing S1 and S2 conformations.

  3. Diagnóstico estrutural de personalidade em psicopatologia psicanalítica Structural diagnosis of personality in psychoanalytical psychopathology

    Directory of Open Access Journals (Sweden)

    Tânia Maria José Aiello Vaisberg

    2000-01-01

    Full Text Available Este artigo apresenta o diagnóstico estrutural de personalidade como prática clínica fundamentada na Psicopatologia Psicanalítica Estrutural. As concepções de Bleger, Bergeret e Winnicott são articuladas visando oferecer subsídios teóricos para o estabelecimento de tal diagnóstico, cuja finalidade principal é orientar decisões clínicas quanto à escolha de técnicas e estratégias psicanalíticas adequadas ao tipo de psicopatologia envolvido em cada caso particular. Procedimentos Projetivos, utilizados transicionalmente nas entrevistas clínicas, são especialmente mencionados, uma vez que possibilitam o acesso, num contexto lúdico e criativo, aos determinantes lógico-emocionais subjacentes às condutas humanas.This article presents the structural diagnosis of personality, as a clinical practice based on Psychoanalytic Structural Psychopathology and established from Bleger, Bergeret and Winnicott’s theoretical conceptions. The aim of this diagnosis consists on guiding the psychoanalyst through clinical decisions about peculiar techniques and strategies, depending on the kind of psychopathology of each particular case. Projective Procedures, transitionally used on clinical interviews, are specially mentioned, once they provide the access, in a ludic and creative basis, to the latent logical-emotional determinants related to human manifestations.

  4. Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism

    Directory of Open Access Journals (Sweden)

    Sensen Zhang

    2017-09-01

    Full Text Available Abstract TRPML1 channel is a non-selective group-2 transient receptor potential (TRP channel with Ca2+ permeability. Located mainly in late endosome and lysosome of all mammalian cell types, TRPML1 is indispensable in the processes of endocytosis, membrane trafficking, and lysosome biogenesis. Mutations of TRPML1 cause a severe lysosomal storage disorder called mucolipidosis type IV (MLIV. In the present study, we determined the cryo-electron microscopy (cryo-EM structures of Mus musculus TRPML1 (mTRPML1 in lipid nanodiscs and Amphipols. Two distinct states of mTRPML1 in Amphipols are added to the closed state, on which could represent two different confirmations upon activation and regulation. The polycystin-mucolipin domain (PMD may sense the luminal/extracellular stimuli and undergo a “move upward” motion during endocytosis, thus triggering the overall conformational change in TRPML1. Based on the structural comparisons, we propose TRPML1 is regulated by pH, Ca2+, and phosphoinositides in a combined manner so as to accommodate the dynamic endocytosis process.

  5. Prevalência de transtornos ansiosos e algumas comorbidades em idosos: um estudo de base populacional

    Directory of Open Access Journals (Sweden)

    Mayara B. Machado

    2016-03-01

    Full Text Available RESUMO Objetivo Avaliar a prevalência de transtornos ansiosos e fatores associados em uma amostra populacional de idosos do Sul de Santa Catarina. Métodos Estudo transversal com base em dados populacionais, que avaliou 1.021 indivíduos idosos entre 60 e 79 anos. Foram realizadas entrevistas domiciliares para aferição de variáveis sobre transtornos ansiosos, por meio do questionário MINI, dados sociodemográficos, hipertensão arterial sistêmica (HAS, infarto agudo do miocárdio (IAM e dosagem de colesterol. Resultados As prevalências entre os transtornos ansiosos foram de 22,0% para o transtorno de ansiedade generalizada (TAG; 14,8% para fobia social (FS; 10,5% para transtorno do pânico (TP; e 8,5% para o transtorno obsessivo-compulsivo (TOC. Além disso, 40,5% dos indivíduos apresentaram pelo menos um transtorno de ansiedade. A distribuição dos transtornos foi semelhante nos dois gêneros; TAG foi mais prevalente nos indivíduos de menor escolaridade; TOC foi mais presente em indivíduos casados ou em união estável. Em relação às variáveis clínicas, HAS foi associada à presença de TOC; FS foi associada com IAM; TOC e FS foram associados com HDL > 40 mg/dL. Conclusão Os dados demonstram que os quadros de ansiedade são muito frequentes em idosos da comunidade, se sobrepõem de forma significativa e estão associados a algumas variáveis clínicas cardiovasculares.

  6. Metacognição em Grupos de Problem-based Learning (PBL

    Directory of Open Access Journals (Sweden)

    Adriana Vargas

    2017-08-01

    Full Text Available Aprendizagem em grupo é um processo que envolve a mobilização de funções cognitivas e desenvolve competências necessárias no decorrer da vida. A Problem-based Learning (PBL, uma proposta de aprendizagem em grupo, enfatiza o desenvolvimento cognitivo e pode potencializar a metacognição. Objetivou-se responder as questões: 1 a PBL é uma metodologia que envolve o desenvolvimento da metacognição? 2 pode-se relacionar os estudos da metacognição no contexto grupal à PBL? Realizou-se o estado do conhecimento do tema, entre 2010 a 2015, contendo os termos metacognition e Problem-based Learning, no portal de periódicos da CAPES. Oito pesquisas foram selecionadas por descreverem evidências empíricas da metacognição em grupos de PBL. A PBL pode ser aplicada aos estudos de aprendizagem em grupo e metacognição, por mobilizar conhecimentos, a tomada de consciência e o autocontrole.

  7. The crystal and solution structure of a putative transcriptional antiterminator from <em>Mycobacterium tuberculosisem>

    DEFF Research Database (Denmark)

    Morth, J.P.; Feng, V.; Perry, L.J.

    2004-01-01

    We describe the crystal structure of Rv1626 from Mycobacterium tuberculosis at 1.48 A resolution and the corresponding solution structure determined from small angle X-ray scattering. The N-terminal domain shows structural homology to the receiver domains found in bacterial two-component systems....... regulators, so far only found in bacteria, and includes NasT, a protein from the assimilatory nitrate/nitrite reductase operon of Azetobacter vinelandii....

  8. Neurocardiology: Structure-Based Function.

    Science.gov (United States)

    Ardell, Jeffrey L; Armour, John Andrew

    2016-09-15

    Cardiac control is mediated via a series of reflex control networks involving somata in the (i) intrinsic cardiac ganglia (heart), (ii) intrathoracic extracardiac ganglia (stellate, middle cervical), (iii) superior cervical ganglia, (iv) spinal cord, (v) brainstem, and (vi) higher centers. Each of these processing centers contains afferent, efferent, and local circuit neurons, which interact locally and in an interdependent fashion with the other levels to coordinate regional cardiac electrical and mechanical indices on a beat-to-beat basis. This control system is optimized to respond to normal physiological stressors (standing, exercise, and temperature); however, it can be catastrophically disrupted by pathological events such as myocardial ischemia. In fact, it is now recognized that autonomic dysregulation is central to the evolution of heart failure and arrhythmias. Autonomic regulation therapy is an emerging modality in the management of acute and chronic cardiac pathologies. Neuromodulation-based approaches that target select nexus points of this hierarchy for cardiac control offer unique opportunities to positively affect therapeutic outcomes via improved efficacy of cardiovascular reflex control. As such, understanding the anatomical and physiological basis for such control is necessary to implement effectively novel neuromodulation therapies. © 2016 American Physiological Society. Compr Physiol 6:1635-1653, 2016. Copyright © 2016 John Wiley & Sons, Inc.

  9. Two-Component Systems of <em>Mycobacterium tuberculosisem>—Structure-Based Approaches

    DEFF Research Database (Denmark)

    Tucker, Paul; Nowak, Elzbieta; Morth, Jens Preben

    2007-01-01

    Mycobacterium tuberculosis contains few two‐component systems compared to many other bacteria, possibly because it has more serine/threonine signaling pathways. Even so, these two‐component systems appear to play an important role in early intracellular survival of the pathogen as well as in aspe...

  10. Organizational structure in process-based organizations

    NARCIS (Netherlands)

    Vanhaverbeke, W.P.M.; Torremans, H.P.M.

    1999-01-01

    This paper investigates the role of the organization structure in process-based organizations. We argue that companies cannot be designed upon organizational processes only or that process management can be simply imposed as an additional structural dimension on top of the existing functional or

  11. Ego-motion based on EM for bionic navigation

    Science.gov (United States)

    Yue, Xiaofeng; Wang, L. J.; Liu, J. G.

    2015-12-01

    Researches have proved that flying insects such as bees can achieve efficient and robust flight control, and biologists have explored some biomimetic principles regarding how they control flight. Based on those basic studies and principles acquired from the flying insects, this paper proposes a different solution of recovering ego-motion for low level navigation. Firstly, a new type of entropy flow is provided to calculate the motion parameters. Secondly, EKF, which has been used for navigation for some years to correct accumulated error, and estimation-Maximization, which is always used to estimate parameters, are put together to determine the ego-motion estimation of aerial vehicles. Numerical simulation on MATLAB has proved that this navigation system provides more accurate position and smaller mean absolute error than pure optical flow navigation. This paper has done pioneering work in bionic mechanism to space navigation.

  12. Efeito de produtos a base de óleo de nim em diferentes formulações no controle de Plutella xylostella (L.,1758) (Lepidoptera: Plutellidae), em couve

    OpenAIRE

    Mondego, Janaina Marques [UNESP

    2011-01-01

    Este trabalho teve por objetivo avaliar a eficiência de diferentes doses e formulações de óleo de nim, seu poder residual e a decomposição no armazenamento, visando o controle de Plutella xylostella (L.), em couve. Os experimentos foram conduzidos em laboratório, sob condições controlada de temperatura (25 ± 2°C) umidade relativa (70 ± 10%) e fotofase (12 horas). Foram utilizadas diferentes doses e formulações do produto a base de nim. As doses utilizadas para larvas de primeiro instar foram:...

  13. Navigating 3D electron microscopy maps with EM-SURFER.

    Science.gov (United States)

    Esquivel-Rodríguez, Juan; Xiong, Yi; Han, Xusi; Guang, Shuomeng; Christoffer, Charles; Kihara, Daisuke

    2015-05-30

    The Electron Microscopy DataBank (EMDB) is growing rapidly, accumulating biological structural data obtained mainly by electron microscopy and tomography, which are emerging techniques for determining large biomolecular complex and subcellular structures. Together with the Protein Data Bank (PDB), EMDB is becoming a fundamental resource of the tertiary structures of biological macromolecules. To take full advantage of this indispensable resource, the ability to search the database by structural similarity is essential. However, unlike high-resolution structures stored in PDB, methods for comparing low-resolution electron microscopy (EM) density maps in EMDB are not well established. We developed a computational method for efficiently searching low-resolution EM maps. The method uses a compact fingerprint representation of EM maps based on the 3D Zernike descriptor, which is derived from a mathematical series expansion for EM maps that are considered as 3D functions. The method is implemented in a web server named EM-SURFER, which allows users to search against the entire EMDB in real-time. EM-SURFER compares the global shapes of EM maps. Examples of search results from different types of query structures are discussed. We developed EM-SURFER, which retrieves structurally relevant matches for query EM maps from EMDB within seconds. The unique capability of EM-SURFER to detect 3D shape similarity of low-resolution EM maps should prove invaluable in structural biology.

  14. Pesquisa em Contabilidade Gerencial com Base no Futuro Realizada no Brasil

    Directory of Open Access Journals (Sweden)

    Ilse Maria Beuren

    2010-08-01

    Full Text Available O estudo objetiva identificar temas que serão abordados no futuro em pesquisas de contabilidade gerencial, considerando-se a terceira metodologia de contabilidade gerencial proposta no estudo de Laitinen (2003, denominada de “Pesquisa em contabilidade gerencial com base no futuro”. Pesquisa descritiva foi realizada com abordagem quantitativa, por meio de questionário aplicado aos professores da área gerencial dos programas de pós-graduação em ciências contábeis do Brasil. Os resultados da pesquisa mostram que a função atual da contabilidade gerencial está focalizada no uso de recursos e na criação de valor. A tendência da contabilidade gerencial na opinião dos respondentes é a criação de valor. Prevêem que a contabilidade gerencial utilizará sistemas com dados monetários e não monetários, métodos de mensuração/avaliação e medidas de desempenho, filosofias e modelos de gestão. Como artefatos de contabilidade gerencial que serão mais utilizados apontaram: custeio variável, preço de transferência, retorno sobre o investimento e orçamento. Em relação à contabilidade financeira, acreditam em preponderância centrada na informação sobre produtos, projetos e planos de negócios.

  15. Base eletronica de dados clinicos e cirurgicos em isquemia cronica de membros inferiores

    Directory of Open Access Journals (Sweden)

    Carlos Seme Nejm Junior

    2013-09-01

    Full Text Available CONTEXTO: Um sistema eletrônico de protocolo seria capaz de armazenar dados clínicos e possibilitar futuras pesquisas, visando a rapidez, eficiência de cruzamentos e análise de tais dados. OBJETIVO: a criar uma base de dados clínicos cirúrgicos em doenças vasculares e, a partir desta, uma base em Isquemia Crônica de Membros Inferiores; b informatizar essa base sob forma de um protocolo eletrônico; c incorporar ao SINPE(c (Sistema Integrado de Protocolos Eletrônicos; d realizar um projeto piloto. MÉTODOS: Criou-se uma base teórica de dados clínicos sobre as doenças vasculares. O protocolo específico foi criado considerando-se as características individuais das doenças causadoras de Isquemia Crônica de Membros Inferiores. Após seu término, essa base eletrônica e informatizada seria incorporada ao SINPE(c. RESULTADOS: O usuário, previamente cadastrado, realizará o cadastro do paciente e selecionará, dentro do protocolo mestre, o protocolo específico em Isquemia Crônica de Membros Inferiores, para acesso aos seus respectivos dados clínicos. Orientado pelas alternativas diretas de preenchimento, o usuário seleciona apenas os dados pertencentes ao seu paciente. Estes podem ser resgatados para pesquisa, mostrando o número de coletas que satisfazem os parâmetros escolhidos e informações estatísticas sobre a mesma. CONCLUSÃO: a a criação da base teórica de dados clínicos e cirúrgicos em doenças vasculares e, a partir desta, em Isquemia Crônica de Membros Inferiores, foi factível; b a informatização da base teórica sob forma de protocolo eletrônico foi exequível; c o protocolo eletrônico mestre e específico poderá ser incorporado ao SINPE(c, d o projeto piloto foi criado com sucesso e testado através do módulo analisador do SINPE(c.

  16. Solution Structure of Reduced Plastocyanin from the Blue-green Alga <em>Anabaena Variabilisem>

    DEFF Research Database (Denmark)

    Badsberg, Ulla; Jørgensen, Anne Marie M.; Gesmar, Henrik

    1996-01-01

    of other plastocyanins (+1 vs -9 +/- 1 at pH > or = 7). The most striking feature of the A.v. PCu structure is the absence of the beta-turn, formed at the remote site by residues (58)-(61) in most higher plant plastocyanins. The displacement caused by the absence of this turn is compensated...

  17. Analysis of surface structures of <em>Cladonia mitisem> podetia in historic and recent collections from Greenland

    DEFF Research Database (Denmark)

    Heide-Jørgensen, Henning; Johnsen, Ib

    1995-01-01

    Field observations in Greenland combined with a scanning electron microscopical survey have revealed a hitherto undescribed correspondence in the distribution of a brownish colour and a crust-like surface structure formed by hyphae at exposed parts of the shoot tips of podetia of Cladonia mitis...

  18. Morphology, genome sequence, and structural proteome of type phage P335 from <em>Lactococcus lactisem>

    DEFF Research Database (Denmark)

    Labrie, Simon J.; Josephsen, Jytte; Neve, Horst

    2008-01-01

    for a shorter tail and a different collar/whisker structure. Its 33,613-bp double-stranded DNA genome had 50 open reading frames. Putative functions were assigned to 29 of them. Unlike other sequenced genomes from lactococcal phages belonging to this species, P335 did not have a lysogeny module. However, it did...... genome. The genetic diversity of the P335 species indicates that they are exceptional models for studying the modular theory of phage evolution....

  19. Rapid Development of Microsatellite Markers with 454 Pyrosequencing in a Vulnerable Fish<em>,> the Mottled Skate<em>, Raja em>pulchra>

    Directory of Open Access Journals (Sweden)

    Jung-Ha Kang

    2012-06-01

    Full Text Available The mottled skate, <em>Raja pulchraem>, is an economically valuable fish. However, due to a severe population decline, it is listed as a vulnerable species by the International Union for Conservation of Nature. To analyze its genetic structure and diversity, microsatellite markers were developed using 454 pyrosequencing. A total of 17,033 reads containing dinucleotide microsatellite repeat units (mean, 487 base pairs were identified from 453,549 reads. Among 32 loci containing more than nine repeat units, 20 primer sets (62% produced strong PCR products, of which 14 were polymorphic. In an analysis of 60 individuals from two <em>R. pulchra em>populations, the number of alleles per locus ranged from 1–10, and the mean allelic richness was 4.7. No linkage disequilibrium was found between any pair of loci, indicating that the markers were independent. The Hardy–Weinberg equilibrium test showed significant deviation in two of the 28 single-loci after sequential Bonferroni’s correction. Using 11 primer sets, cross-species amplification was demonstrated in nine related species from four families within two classes. Among the 11 loci amplified from three other <em>Rajidae> family species; three loci were polymorphic. A monomorphic locus was amplified in all three <em>Rajidae> family species and the <em>Dasyatidae> family. Two <em>Rajidae> polymorphic loci amplified monomorphic target DNAs in four species belonging to the Carcharhiniformes class, and another was polymorphic in two Carcharhiniformes species.

  20. Holistic corpus-based dialectology Dialetologia holística baseada em corpus

    Directory of Open Access Journals (Sweden)

    Benedikt Szmrecsanyi

    2011-01-01

    Full Text Available This paper is concerned with sketching future directions for corpus-based dialectology. We advocate a holistic approach to the study of geographically conditioned linguistic variability, and we present a suitable methodology, 'corpusbased dialectometry', in exactly this spirit. Specifically, we argue that in order to live up to the potential of the corpus-based method, practitioners need to (i abandon their exclusive focus on individual linguistic features in favor of the study of feature aggregates, (ii draw on computationally advanced multivariate analysis techniques (such as multidimensional scaling, cluster analysis, and principal component analysis, and (iii aid interpretation of empirical results by marshalling state-of-the-art data visualization techniques. To exemplify this line of analysis, we present a case study which explores joint frequency variability of 57 morphosyntax features in 34 dialects all over Great Britain.Este artigo debruça-se sobre o esboço propositivo de futuras direções para a dialetologia baseada em corpus. Defendemos uma abordagem holística para o estudo da variabilidade linguística geograficamente condicionada, e apresentamos uma metodologia adequada para tal - a dialetometria baseada em corpus. Mais especificamente, defendemos que para que se obtenham todos os resultados esperados da metodologia de corpus, pesquisadores devem: (i abandonar seu foco exclusivo em traços linguísticos individuais em favor do estudo dos agregados de traços, (ii amparar-se em métodos computacionais avançados de técnicas de análise multivariada (tais como escalagem multidimensional, análise de clusters, e análise de componente principal, e (iii auxiliar a interpretação de resultados empíricos através da utilização do estado da arte em técnicas de visualização. A fim de exemplificarmos essa linha de análise, apresentamos um estudo de caso que explora a variabilidade da frequência agregada de 57 tra

  1. A Study of Wind Turbine Comprehensive Operational Assessment Model Based on EM-PCA Algorithm

    Science.gov (United States)

    Zhou, Minqiang; Xu, Bin; Zhan, Yangyan; Ren, Danyuan; Liu, Dexing

    2018-01-01

    To assess wind turbine performance accurately and provide theoretical basis for wind farm management, a hybrid assessment model based on Entropy Method and Principle Component Analysis (EM-PCA) was established, which took most factors of operational performance into consideration and reach to a comprehensive result. To verify the model, six wind turbines were chosen as the research objects, the ranking obtained by the method proposed in the paper were 4#>6#>1#>5#>2#>3#, which are completely in conformity with the theoretical ranking, which indicates that the reliability and effectiveness of the EM-PCA method are high. The method could give guidance for processing unit state comparison among different units and launching wind farm operational assessment.

  2. Structure-based barcoding of proteins.

    Science.gov (United States)

    Metri, Rahul; Jerath, Gaurav; Kailas, Govind; Gacche, Nitin; Pal, Adityabarna; Ramakrishnan, Vibin

    2014-01-01

    A reduced representation in the format of a barcode has been developed to provide an overview of the topological nature of a given protein structure from 3D coordinate file. The molecular structure of a protein coordinate file from Protein Data Bank is first expressed in terms of an alpha-numero code and further converted to a barcode image. The barcode representation can be used to compare and contrast different proteins based on their structure. The utility of this method has been exemplified by comparing structural barcodes of proteins that belong to same fold family, and across different folds. In addition to this, we have attempted to provide an illustration to (i) the structural changes often seen in a given protein molecule upon interaction with ligands and (ii) Modifications in overall topology of a given protein during evolution. The program is fully downloadable from the website http://www.iitg.ac.in/probar/. © 2013 The Protein Society.

  3. Data base on structural materials aging properties

    International Nuclear Information System (INIS)

    Oland, C.B.

    1992-01-01

    The US Nuclear Regulatory Commission has initiated a Structural Aging Program at the Oak Ridge National Laboratory to identify potential structural safety issues related to continued service of nuclear power plants and to establish criteria for evaluating and resolving these issues. One of the tasks in this program focuses on the establishment of a Structural Materials Information Center where long-term and environment-dependent properties of concretes and other structural materials are being collected and assembled into a data base. These properties will be used to evaluate the current condition of critical structural components in nuclear power plants and to estimate the future performance of these materials during the continued service period

  4. IPE data base structure and insights

    International Nuclear Information System (INIS)

    Lehner, J.; Youngblood, R.

    1993-01-01

    A data base (the ''IPE Insights Data Base''), has been developed that stores data obtained from the Individual Plant Examinations (IPEs) which licensees of nuclear power plants are conducting in response to the Nuclear Regulatory Commission's (NRC) Generic Letter GL88-20. The data base, which is a collection of linked dbase files, stores information about individual plant designs, core damage frequency, and containment performance in a uniform, structured way. This data base can be queried and used as a computational tool to derive insights regarding the plants for which data is stored. This paper sets out the objectives of the IPE Insights Data Base, describes its structure and contents, illustrates sample queries, and discusses possible future uses

  5. IPE data base structure and insights

    International Nuclear Information System (INIS)

    Lehner, J.; Youngblood, R.

    1994-01-01

    A data base (the open-quotes IPE Insights Data Baseclose quotes), has been developed that stores data obtained from the Individual Plant Examinations (IPEs) which licensees of nuclear power plants are conducting in response to the Nuclear Regulatory Commission's (NRC) Generic Letter GL88-20. The data base, which is a collection of linked dBase files, stores information about individual plant designs, core damage frequency, and containment performance in a uniform, structured way. This data base can be queried and used as a computational tool to derive insights regarding the plants for which data is stored. This paper sets out the objectives of the IPE Insights Data Base, describes its structure and contents, illustrates sample queries, and discusses possible future uses

  6. Crescimento de mudas de Eucalyptus camaldulensis em substratos à base de casca de arroz carbonizada

    Directory of Open Access Journals (Sweden)

    Dagma Kratz

    2016-06-01

    Full Text Available RESUMO Com base na importância do substrato na produção de mudas florestais, objetivou-se, com este trabalho, avaliar a viabilidade técnica de 13 substratos, preparados com misturas de substrato comercial à base de casca de pinus e vermiculita (SC, casca de arroz carbonizada com diferentes granulometrias [maior que 2 mm (CAC1, CAC com granulometria entre 1 - 2 mm (CAC2, CAC com granulometria entre 0,5 - 1 mm (CAC3, CAC com granulometria menor que 0,5 mm (CAC4], fibra de coco (FC e vermiculita média (VM, na produção de mudas de Eucalyptus camaldulensis, e a correlação de suas propriedades físicas e químicas com seu crescimento. Foram utilizados tubetes de 55 cm³. As mudas permaneceram 60 dias em estufa de vidro e 30 dias a pleno sol. Foram avaliadas a altura, diâmetro de colo, fitomassas secas aérea e radicial, facilidade de retirada do tubete, agregação das raízes ao substrato e relação entre altura e diâmetro de colo. Concluiu-se que o substrato formado por CAC pura, em diferentes granulometrias e em mistura com os outros componentes, é viável tecnicamente para a produção de mudas de Eucalyptus camaldulensis, embora aquele formado pela mistura de 50% de CAC e VM tenha resultado em maior crescimento das mudas. As propriedades dos substratos, densidade aparente, pH e capacidade de troca catiônica são importantes na produção de mudas, pois apresentaram correlações significativas com as variáveis biométricas.

  7. Reliability based Design of Coastal Structures

    DEFF Research Database (Denmark)

    Burcharth, H. F.

    2003-01-01

    Conventional design practice for coastal structures is deterministic in nature and is based on the concept of a design load which should not exceed the resistance (carrying capacity) of the structure. The design load is usually defined on a probabilistic basis as a characteristic value of the load......, for example the expectation (mean) value of the 100-year return period event. However, this selection is often made without consideration of the involved uncertainties. In most cases the resistance is defined in terms of the load that causes a certain design impact or damage to the structure...

  8. Direct imaging electron microscopy (EM) methods in modern structural biology: overview and comparison with X-ray crystallography and single-particle cryo-EM reconstruction in the studies of large macromolecules.

    Science.gov (United States)

    Miyaguchi, Katsuyuki

    2014-10-01

    Determining the structure of macromolecules is important for understanding their function. The fine structure of large macromolecules is currently studied primarily by X-ray crystallography and single-particle cryo-electron microscopy (EM) reconstruction. Before the development of these techniques, macromolecular structure was often examined by negative-staining, rotary-shadowing and freeze-etching EM, which are categorised here as 'direct imaging EM methods'. In this review, the results are summarised by each of the above techniques and compared with respect to four macromolecules: the ryanodine receptor, cadherin, rhodopsin and the ribosome-translocon complex (RTC). The results of structural analysis of the ryanodine receptor and cadherin are consistent between each technique. The results obtained for rhodopsin vary to some extent within each technique and between the different techniques. Finally, the results for RTC are inconsistent between direct imaging EM and other analytical techniques, especially with respect to the space within RTC, the reasons for which are discussed. Then, the role of direct imaging EM methods in modern structural biology is discussed. Direct imaging methods should support and verify the results obtained by other analytical methods capable of solving three-dimensional molecular architecture, and they should still be used as a primary tool for studying macromolecule structure in vivo. © 2014 Société Française des Microscopies and Société de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd.

  9. Kalman filter-based EM-optical sensor fusion for needle deflection estimation.

    Science.gov (United States)

    Jiang, Baichuan; Gao, Wenpeng; Kacher, Daniel; Nevo, Erez; Fetics, Barry; Lee, Thomas C; Jayender, Jagadeesan

    2018-04-01

    In many clinical procedures such as cryoablation that involves needle insertion, accurate placement of the needle's tip at the desired target is the major issue for optimizing the treatment and minimizing damage to the neighboring anatomy. However, due to the interaction force between the needle and tissue, considerable error in intraoperative tracking of the needle tip can be observed as needle deflects. In this paper, measurements data from an optical sensor at the needle base and a magnetic resonance (MR) gradient field-driven electromagnetic (EM) sensor placed 10 cm from the needle tip are used within a model-integrated Kalman filter-based sensor fusion scheme. Bending model-based estimations and EM-based direct estimation are used as the measurement vectors in the Kalman filter, thus establishing an online estimation approach. Static tip bending experiments show that the fusion method can reduce the mean error of the tip position estimation from 29.23 mm of the optical sensor-based approach to 3.15 mm of the fusion-based approach and from 39.96 to 6.90 mm, at the MRI isocenter and the MRI entrance, respectively. This work established a novel sensor fusion scheme that incorporates model information, which enables real-time tracking of needle deflection with MRI compatibility, in a free-hand operating setup.

  10. Cryptic speciation in the recently discovered American cycliophoran <em>Symbion americanusem>; genetic structure and population expansion

    DEFF Research Database (Denmark)

    Baker, J.M.; Funch, Peter; Giribet, G.

    2007-01-01

      Symbion americanus was recently described as the second species in the phylum Cycliophora, living commensally on the American commercial lobster Homarus americanus. A previous genetic analysis of American and European populations of cycliophorans suggested that haplotype divergence in S....... americanus was much greater than in its European counterpart S. pandora. This study examined the population structure and demographics of 169 individuals thought to belong to S. americanus collected from lobsters over 13 North American localities (Nova Scotia, Canada to Maryland, USA) between October 2003...... and January 2006. Cytochrome c oxidase subunit I sequence data clearly suggested the presence of three cryptic lineages in a species complex, often co-occurring in the same lobster specimens. One of these lineages, named the "G" lineage, was represented by very few individuals and therefore was excluded from...

  11. Cognitive diagnostic assessment based on knowledge structure

    Directory of Open Access Journals (Sweden)

    Huang Sue-Fen

    2018-01-01

    Full Text Available The purpose of this study is to provide an integrated method of fuzzy theory basis for individualized concept structure analysis. In order to insight the misconception of learning basic mathematics and progress teaching. This method integrates Fuzzy Logic Model of Perception (FLMP and Interpretive Structural Modelling (ISM. The combined algorithm could analyze individualized concepts structure based on the comparisons with concept structure of expert. In this paper, some well-known knowledge structure assessment methods will be discussed. For item connection, Bart et al ordering theory and Takeya’s item relational structure provided ordering coefficient to construct item relationships and hierarchies. For concepts or skills connection, Warfield’s ISM and Lin et al Concept Advanced Interpretive Structural Modelling (CAISM provided to construct graphic relationship among elements and display the individualized concept hierarchy structure by numeric and picture. Samples contain 427 which come from Min-Hwei Junior College. Subjects were analyzed by CAISM. It shows the traditional assessment is not the only criteria; it must be combined with other assessment tools. The result shows that CAISM gives meaningful learning and lacks of learners.

  12. Allometric and Isometric variations in the Italian <em>Apodemus sylvaticusem> and <em>Apodemus flavicollisem> with respect to the conditions of allopatry and sympatry / Variazioni allometriche e isometriche in <em>Apodemus sylvaticusem> e <em>Apodemus flavicollisem> italiani, rispetto alle condizioni di allopatria e simpatria

    Directory of Open Access Journals (Sweden)

    Giovanni Amori

    1986-12-01

    thickness and positively linked to skull length is allometric. The intraspecific comparison perhaps reflects a gradient of skull length, whereas the interspecific one a difference in size and thickness between <em>A. sylvaticusem> and <em>A. flavicollisem> skull. On the other hand it appears, from Filippucci et al. (1984 that the importance of genetical factors is highly dependent on the particular character examined and on the species under study. In such a manner, results which are ecologically rather similar could be obtained with different processes. Conversely, the isometry and allopatry of characters seems to depend on different ways from the taxonomical, evolutive and ecologica1 context taken into account. Namely, some characters seem to be more subject to the competitive pressure, others to the genera1 structural model of the species. On the other hand, it is not sure that competition can explain all the observed phenomena, some of which may have a multiple base. More research is needed in order to elucidate such casual aspects of observed phenomena. Riassunto Su <em>Apodemus sylvaticusem> dell'Italia insulare e su <em>A. sylvaticusem> ed <em>Apodemus flavicollisem> dell'Italia peninsulare sono stati studiati alcuni caratteri cranici, evidenziandone l'isometria o l'allometria. Su detti caratteri sono stati verificati e discussi i modelli eco1ogici: variazione di nicchia, spostamento dei caratteri, convergenza fenotipica e parallelismo di caratteri in condizione di simpatria e/o allopatria.

  13. Genetic diversity and landscape genetic structure of otter (<em>Lutra lutraem>) populations in Europe

    DEFF Research Database (Denmark)

    Mucci, Nadia; Arrendal, Johanna; Ansorge, Hermann

    2010-01-01

    Eurasian otter populations strongly declined and partially disappeared due to global and local causes (habitat destruction, water pollution, human persecution) in parts of their continental range. Conservation strategies, based on reintroduction projects or restoration of dispersal corridors...... and landscape genetic analyses however indicate that local populations are genetically differentiated, perhaps as consequence of post-glacial demographic fluctuations and recent isolation. These results delineate a framework that should be used for implementing conservation programs in Europe, particularly...

  14. Structured Performance Analysis for Component Based Systems

    OpenAIRE

    Salmi , N.; Moreaux , Patrice; Ioualalen , M.

    2012-01-01

    International audience; The Component Based System (CBS) paradigm is now largely used to design software systems. In addition, performance and behavioural analysis remains a required step for the design and the construction of efficient systems. This is especially the case of CBS, which involve interconnected components running concurrent processes. % This paper proposes a compositional method for modeling and structured performance analysis of CBS. Modeling is based on Stochastic Well-formed...

  15. Inatividade física em idosos não institucionalizados: estudo de base populacional

    Directory of Open Access Journals (Sweden)

    Bruno Morbeck de Queiroz

    2014-08-01

    Full Text Available O objetivo deste estudo é descrever a prevalência de inatividade física e analisar os fatores sociodemográficos, de estilo de vida e condições de saúde associados em idosos do Nordeste brasileiro. Estudo descritivo e de associação, baseado em dados secundários originados de uma pesquisa epidemiológica de base populacional envolvendo 316 idosos. O nível de atividade física foi avaliado por meio do International Physical Activity Questionnaire. As variáveis explanatórias foram: sexo, grupo etário, arranjo familiar, sabe ler e escrever, trabalho remunerado ou voluntário, tabagismo, sintomatologia depressiva, pressão arterial elevada, hiperglicemia em jejum e capacidade funcional. A prevalência da inatividade física foi de 46,5. Os resultados da análise múltipla indicaram que a inatividade física foi positivamente associada ao grupo etário ≥ 80 anos (RP = 2,37, a falta de ocupação (RP = 4,86 e a dependência nas atividades instrumentais de vida diária (RP = 1,47 e nas atividades básicas de vida diária (RP = 1,60. A inatividade física foi altamente prevalente na população estudada, tornando-se imprescindível a discussão de programas que incentivem e possibilite maior adesão à prática da atividade física, tendo em vista o combate a inatividade física e os fatores de risco decorrentes deste comportamento.

  16. A Study on GPU-based Iterative ML-EM Reconstruction Algorithm for Emission Computed Tomographic Imaging Systems

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Woo Seok; Kim, Soo Mee; Park, Min Jae; Lee, Dong Soo; Lee, Jae Sung [Seoul National University, Seoul (Korea, Republic of)

    2009-10-15

    The maximum likelihood-expectation maximization (ML-EM) is the statistical reconstruction algorithm derived from probabilistic model of the emission and detection processes. Although the ML-EM has many advantages in accuracy and utility, the use of the ML-EM is limited due to the computational burden of iterating processing on a CPU (central processing unit). In this study, we developed a parallel computing technique on GPU (graphic processing unit) for ML-EM algorithm. Using Geforce 9800 GTX+ graphic card and CUDA (compute unified device architecture) the projection and backprojection in ML-EM algorithm were parallelized by NVIDIA's technology. The time delay on computations for projection, errors between measured and estimated data and backprojection in an iteration were measured. Total time included the latency in data transmission between RAM and GPU memory. The total computation time of the CPU- and GPU-based ML-EM with 32 iterations were 3.83 and 0.26 sec, respectively. In this case, the computing speed was improved about 15 times on GPU. When the number of iterations increased into 1024, the CPU- and GPU-based computing took totally 18 min and 8 sec, respectively. The improvement was about 135 times and was caused by delay on CPU-based computing after certain iterations. On the other hand, the GPU-based computation provided very small variation on time delay per iteration due to use of shared memory. The GPU-based parallel computation for ML-EM improved significantly the computing speed and stability. The developed GPU-based ML-EM algorithm could be easily modified for some other imaging geometries

  17. A Study on GPU-based Iterative ML-EM Reconstruction Algorithm for Emission Computed Tomographic Imaging Systems

    International Nuclear Information System (INIS)

    Ha, Woo Seok; Kim, Soo Mee; Park, Min Jae; Lee, Dong Soo; Lee, Jae Sung

    2009-01-01

    The maximum likelihood-expectation maximization (ML-EM) is the statistical reconstruction algorithm derived from probabilistic model of the emission and detection processes. Although the ML-EM has many advantages in accuracy and utility, the use of the ML-EM is limited due to the computational burden of iterating processing on a CPU (central processing unit). In this study, we developed a parallel computing technique on GPU (graphic processing unit) for ML-EM algorithm. Using Geforce 9800 GTX+ graphic card and CUDA (compute unified device architecture) the projection and backprojection in ML-EM algorithm were parallelized by NVIDIA's technology. The time delay on computations for projection, errors between measured and estimated data and backprojection in an iteration were measured. Total time included the latency in data transmission between RAM and GPU memory. The total computation time of the CPU- and GPU-based ML-EM with 32 iterations were 3.83 and 0.26 sec, respectively. In this case, the computing speed was improved about 15 times on GPU. When the number of iterations increased into 1024, the CPU- and GPU-based computing took totally 18 min and 8 sec, respectively. The improvement was about 135 times and was caused by delay on CPU-based computing after certain iterations. On the other hand, the GPU-based computation provided very small variation on time delay per iteration due to use of shared memory. The GPU-based parallel computation for ML-EM improved significantly the computing speed and stability. The developed GPU-based ML-EM algorithm could be easily modified for some other imaging geometries

  18. Yellow fluorescent protein phiYFPv (Phialidium): structure and structure-based mutagenesis

    Energy Technology Data Exchange (ETDEWEB)

    Pletneva, Nadya V.; Pletnev, Vladimir Z., E-mail: vzpletnev@gmail.com; Souslova, Ekaterina; Chudakov, Dmitry M. [Russian Academy of Sciences, Moscow (Russian Federation); Lukyanov, Sergey [Russian Academy of Sciences, Moscow (Russian Federation); Nizhny Novgorod State Medical Academy, Nizhny Novgorod (Russian Federation); Martynov, Vladimir I.; Arhipova, Svetlena; Artemyev, Igor [Russian Academy of Sciences, Moscow (Russian Federation); Wlodawer, Alexander [National Cancer Institute, Frederick, MD 21702 (United States); Dauter, Zbigniew [National Cancer Institute, Argonne, IL 60439 (United States); Pletnev, Sergei [National Cancer Institute, Argonne, IL 60439 (United States); SAIC-Frederick, 9700 South Cass Avenue, Argonne, IL 60439 (United States); Russian Academy of Sciences, Moscow (Russian Federation)

    2013-06-01

    The yellow fluorescent protein phiYFPv with improved folding has been developed from the spectrally identical wild-type phiYFP found in the marine jellyfish Phialidium. The yellow fluorescent protein phiYFPv (λ{sub em}{sup max} ≃ 537 nm) with improved folding has been developed from the spectrally identical wild-type phiYFP found in the marine jellyfish Phialidium. The latter fluorescent protein is one of only two known cases of naturally occurring proteins that exhibit emission spectra in the yellow–orange range (535–555 nm). Here, the crystal structure of phiYFPv has been determined at 2.05 Å resolution. The ‘yellow’ chromophore formed from the sequence triad Thr65-Tyr66-Gly67 adopts the bicyclic structure typical of fluorophores emitting in the green spectral range. It was demonstrated that perfect antiparallel π-stacking of chromophore Tyr66 and the proximal Tyr203, as well as Val205, facing the chromophore phenolic ring are chiefly responsible for the observed yellow emission of phiYFPv at 537 nm. Structure-based site-directed mutagenesis has been used to identify the key functional residues in the chromophore environment. The obtained results have been utilized to improve the properties of phiYFPv and its homologous monomeric biomarker tagYFP.

  19. Human Skin Barrier Structure and Function Analyzed by Cryo-EM and Molecular Dynamics Simulation.

    Science.gov (United States)

    Lundborg, Magnus; Narangifard, Ali; Wennberg, Christian L; Lindahl, Erik; Daneholt, Bertil; Norlén, Lars

    2018-04-24

    In the present study we have analyzed the molecular structure and function of the human skin's permeability barrier using molecular dynamics simulation validated against cryo-electron microscopy data from near native skin. The skin's barrier capacity is located to an intercellular lipid structure embedding the cells of the superficial most layer of skin - the stratum corneum. According to the splayed bilayer model (Iwai et al., 2012) the lipid structure is organized as stacked bilayers of ceramides in a splayed chain conformation with cholesterol associated with the ceramide sphingoid moiety and free fatty acids associated with the ceramide fatty acid moiety. However, knowledge about the lipid structure's detailed molecular organization, and the roles of its different lipid constituents, remains circumstantial. Starting from a molecular dynamics model based on the splayed bilayer model, we have, by stepwise structural and compositional modifications, arrived at a thermodynamically stable molecular dynamics model expressing simulated electron microscopy patterns matching original cryo-electron microscopy patterns from skin extremely closely. Strikingly, the closer the individual molecular dynamics models' lipid composition was to that reported in human stratum corneum, the better was the match between the models' simulated electron microscopy patterns and the original cryo-electron microscopy patterns. Moreover, the closest-matching model's calculated water permeability and thermotropic behaviour were found compatible with that of human skin. The new model may facilitate more advanced physics-based skin permeability predictions of drugs and toxicants. The proposed procedure for molecular dynamics based analysis of cellular cryo-electron microscopy data might be applied to other biomolecular systems. Copyright © 2018. Published by Elsevier Inc.

  20. Vibrational Based Inspection of Civil Engineering Structures

    DEFF Research Database (Denmark)

    Rytter, Anders

    at the University of Aalborg from 1988 to 1991. Secondly, a research project, In-Field Vibration Based Inspection of Civil Engineering Structures, which has been performed as a pilot project by the Consulting Engineers Rambøll, Hannemann and Højlund in cooperation with the department of Building Technology......The thesis has been written in relation to two different research projects. Firstly, an offshore test programme, Integrated Experimental/Numerical Analysis of the Dynamic behavior of offshore structures, which was performed at the department of Building Technology and Structural Engineering...... and Structural Engineering at the University of Aalborg since the beginning of 1992. Both projects have been supported by the Danish Technical Research Council. Further, the first mentioned project was supported by the Danish Energy Agency. Their financial support is gratefully acknowledged....

  1. Electronic structure of Fe-based superconductors

    Indian Academy of Sciences (India)

    Abstract. Fe-based superconductors have drawn much attention during the last decade due to the presence of superconductivity in materials containing the magnetic element, Fe, and the coexistence of superconductivity and magnetism. Extensive study of the electronic structure of these systems suggested the dominant ...

  2. Electronic structure of Fe-based superconductors

    Indian Academy of Sciences (India)

    2015-05-29

    May 29, 2015 ... Fe-based superconductors have drawn much attention during the last decade due to the presence of superconductivity in materials containing the magnetic element, Fe, and the coexistence of superconductivity and magnetism. Extensive study of the electronic structure of these systems suggested the ...

  3. 3D airborne EM modeling based on the spectral-element time-domain (SETD) method

    Science.gov (United States)

    Cao, X.; Yin, C.; Huang, X.; Liu, Y.; Zhang, B., Sr.; Cai, J.; Liu, L.

    2017-12-01

    In the field of 3D airborne electromagnetic (AEM) modeling, both finite-difference time-domain (FDTD) method and finite-element time-domain (FETD) method have limitations that FDTD method depends too much on the grids and time steps, while FETD requires large number of grids for complex structures. We propose a time-domain spectral-element (SETD) method based on GLL interpolation basis functions for spatial discretization and Backward Euler (BE) technique for time discretization. The spectral-element method is based on a weighted residual technique with polynomials as vector basis functions. It can contribute to an accurate result by increasing the order of polynomials and suppressing spurious solution. BE method is a stable tine discretization technique that has no limitation on time steps and can guarantee a higher accuracy during the iteration process. To minimize the non-zero number of sparse matrix and obtain a diagonal mass matrix, we apply the reduced order integral technique. A direct solver with its speed independent of the condition number is adopted for quickly solving the large-scale sparse linear equations system. To check the accuracy of our SETD algorithm, we compare our results with semi-analytical solutions for a three-layered earth model within the time lapse 10-6-10-2s for different physical meshes and SE orders. The results show that the relative errors for magnetic field B and magnetic induction are both around 3-5%. Further we calculate AEM responses for an AEM system over a 3D earth model in Figure 1. From numerical experiments for both 1D and 3D model, we draw the conclusions that: 1) SETD can deliver an accurate results for both dB/dt and B; 2) increasing SE order improves the modeling accuracy for early to middle time channels when the EM field diffuses fast so the high-order SE can model the detailed variation; 3) at very late time channels, increasing SE order has little improvement on modeling accuracy, but the time interval plays

  4. Microsatellite Loci in the Gypsophyte <em>Lepidium subulatum em>(Brassicaceae, and Transferability to Other <em>Lepidieae>

    Directory of Open Access Journals (Sweden)

    José Gabriel Segarra-Moragues

    2012-09-01

    Full Text Available Polymorphic microsatellite markers were developed for the Ibero-North African, strict gypsophyte <em>Lepidium subulatumem> to unravel the effects of habitat fragmentation in levels of genetic diversity, genetic structure and gene flow among its populations. Using 454 pyrosequencing 12 microsatellite loci including di- and tri-nucleotide repeats were characterized in <em>L. subulatumem>. They amplified a total of 80 alleles (2–12 alleles per locus in a sample of 35 individuals of <em>L. subulatumem>, showing relatively high levels of genetic diversity, <em>H>O = 0.645, <em>H>E = 0.627. Cross-species transferability of all 12 loci was successful for the Iberian endemics <em>Lepidium cardaminesem>, <em>Lepidium stylatumem>, and the widespread, <em>Lepidium graminifoliumem> and one species each of two related genera, <em>Cardaria drabaem> and <em>Coronopus didymusem>. These microsatellite primers will be useful to investigate genetic diversity, population structure and to address conservation genetics in species of <em>Lepidium>.

  5. Mapping population-based structural connectomes.

    Science.gov (United States)

    Zhang, Zhengwu; Descoteaux, Maxime; Zhang, Jingwen; Girard, Gabriel; Chamberland, Maxime; Dunson, David; Srivastava, Anuj; Zhu, Hongtu

    2018-05-15

    Advances in understanding the structural connectomes of human brain require improved approaches for the construction, comparison and integration of high-dimensional whole-brain tractography data from a large number of individuals. This article develops a population-based structural connectome (PSC) mapping framework to address these challenges. PSC simultaneously characterizes a large number of white matter bundles within and across different subjects by registering different subjects' brains based on coarse cortical parcellations, compressing the bundles of each connection, and extracting novel connection weights. A robust tractography algorithm and streamline post-processing techniques, including dilation of gray matter regions, streamline cutting, and outlier streamline removal are applied to improve the robustness of the extracted structural connectomes. The developed PSC framework can be used to reproducibly extract binary networks, weighted networks and streamline-based brain connectomes. We apply the PSC to Human Connectome Project data to illustrate its application in characterizing normal variations and heritability of structural connectomes in healthy subjects. Copyright © 2018 Elsevier Inc. All rights reserved.

  6. NMR in structure-based drug design.

    Science.gov (United States)

    Carneiro, Marta G; Ab, Eiso; Theisgen, Stephan; Siegal, Gregg

    2017-11-08

    NMR spectroscopy is a powerful technique that can provide valuable structural information for drug discovery endeavors. Here, we discuss the strengths (and limitations) of NMR applications to structure-based drug discovery, highlighting the different levels of resolution and throughput obtainable. Additionally, the emerging field of paramagnetic NMR in drug discovery and recent developments in approaches to speed up and automate protein-observed NMR data collection and analysis are discussed. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

  7. Intelligent-based Structural Damage Detection Model

    International Nuclear Information System (INIS)

    Lee, Eric Wai Ming; Yu, K.F.

    2010-01-01

    This paper presents the application of a novel Artificial Neural Network (ANN) model for the diagnosis of structural damage. The ANN model, denoted as the GRNNFA, is a hybrid model combining the General Regression Neural Network Model (GRNN) and the Fuzzy ART (FA) model. It not only retains the important features of the GRNN and FA models (i.e. fast and stable network training and incremental growth of network structure) but also facilitates the removal of the noise embedded in the training samples. Structural damage alters the stiffness distribution of the structure and so as to change the natural frequencies and mode shapes of the system. The measured modal parameter changes due to a particular damage are treated as patterns for that damage. The proposed GRNNFA model was trained to learn those patterns in order to detect the possible damage location of the structure. Simulated data is employed to verify and illustrate the procedures of the proposed ANN-based damage diagnosis methodology. The results of this study have demonstrated the feasibility of applying the GRNNFA model to structural damage diagnosis even when the training samples were noise contaminated.

  8. Intelligent-based Structural Damage Detection Model

    Science.gov (United States)

    Lee, Eric Wai Ming; Yu, Kin Fung

    2010-05-01

    This paper presents the application of a novel Artificial Neural Network (ANN) model for the diagnosis of structural damage. The ANN model, denoted as the GRNNFA, is a hybrid model combining the General Regression Neural Network Model (GRNN) and the Fuzzy ART (FA) model. It not only retains the important features of the GRNN and FA models (i.e. fast and stable network training and incremental growth of network structure) but also facilitates the removal of the noise embedded in the training samples. Structural damage alters the stiffness distribution of the structure and so as to change the natural frequencies and mode shapes of the system. The measured modal parameter changes due to a particular damage are treated as patterns for that damage. The proposed GRNNFA model was trained to learn those patterns in order to detect the possible damage location of the structure. Simulated data is employed to verify and illustrate the procedures of the proposed ANN-based damage diagnosis methodology. The results of this study have demonstrated the feasibility of applying the GRNNFA model to structural damage diagnosis even when the training samples were noise contaminated.

  9. Data Extraction Based on Page Structure Analysis

    Directory of Open Access Journals (Sweden)

    Ren Yichao

    2017-01-01

    Full Text Available The information we need has some confusing problems such as dispersion and different organizational structure. In addition, because of the existence of unstructured data like natural language and images, extracting local content pages is extremely difficult. In the light of of the problems above, this article will apply a method combined with page structure analysis algorithm and page data extraction algorithm to accomplish the gathering of network data. In this way, the problem that traditional complex extraction model behave poorly when dealing with large-scale data is perfectly solved and the page data extraction efficiency is also boosted to a new level. In the meantime, the article will also make a comparison about pages and content of different types between the methods of DOM structure based on the page and HTML regularities of distribution. After all of those, we may find a more efficient extract method.

  10. Deployable structures for a human lunar base

    Science.gov (United States)

    Gruber, Petra; Häuplik, Sandra; Imhof, Barbara; Özdemir, Kürsad; Waclavicek, Rene; Perino, Maria Antoinetta

    2007-06-01

    The study Lunar exploration architecture—deployable structures for a lunar base was performed within the Alcatel Alenia Space “Lunar Exploration Architecture” study for the European Space Agency. The purpose of the study was to investigate bionic concepts applicable to deployable structures and to interpret the findings for possible implementation concepts. The study aimed at finding innovative solutions for deployment possibilities. Translating folding/unfolding principles from nature, candidate geometries were developed and researched using models, drawings and visualisations. The use of materials, joints between structural elements and construction details were investigated for these conceptual approaches. Reference scenarios were used to identify the technical and environmental conditions, which served as design drivers. Mechanical issues and the investigation of deployment processes narrowed the selection down to six chosen concepts. Their applicability was evaluated at a conceptual stage in relation to the timescale of the mission.

  11. Reliability Based Optimization of Structural Systems

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    1987-01-01

    The optimization problem to design structural systems such that the reliability is satisfactory during the whole lifetime of the structure is considered in this paper. Some of the quantities modelling the loads and the strength of the structure are modelled as random variables. The reliability...... is estimated using first. order reliability methods ( FORM ). The design problem is formulated as the optimization problem to minimize a given cost function such that the reliability of the single elements satisfies given requirements or such that the systems reliability satisfies a given requirement....... For these optimization problems it is described how a sensitivity analysis can be performed. Next, new optimization procedures to solve the optimization problems are presented. Two of these procedures solve the system reliability based optimization problem sequentially using quasi-analytical derivatives. Finally...

  12. Cryo-EM structure of human adenovirus D26 reveals the conservation of structural organization among human adenoviruses.

    Science.gov (United States)

    Yu, Xiaodi; Veesler, David; Campbell, Melody G; Barry, Mary E; Asturias, Francisco J; Barry, Michael A; Reddy, Vijay S

    2017-05-01

    Human adenoviruses (HAdVs) cause acute respiratory, ocular, and gastroenteric diseases and are also frequently used as gene and vaccine delivery vectors. Unlike the archetype human adenovirus C5 (HAdV-C5), human adenovirus D26 (HAdV-D26) belongs to species-D HAdVs, which target different cellular receptors, and is differentially recognized by immune surveillance mechanisms. HAdV-D26 is being championed as a lower seroprevalent vaccine and oncolytic vector in preclinical and human clinical studies. To understand the molecular basis for their distinct biological properties and independently validate the structures of minor proteins, we determined the first structure of species-D HAdV at 3.7 Å resolution by cryo-electron microscopy. All the hexon hypervariable regions (HVRs), including HVR1, have been identified and exhibit a distinct organization compared to those of HAdV-C5. Despite the differences in the arrangement of helices in the coiled-coil structures, protein IX molecules form a continuous hexagonal network on the capsid exterior. In addition to the structurally conserved region (3 to 300) of IIIa, we identified an extra helical domain comprising residues 314 to 390 that further stabilizes the vertex region. Multiple (two to three) copies of the cleaved amino-terminal fragment of protein VI (pVIn) are observed in each hexon cavity, suggesting that there could be ≥480 copies of VI present in HAdV-D26. In addition, a localized asymmetric reconstruction of the vertex region provides new details of the three-pronged "claw hold" of the trimeric fiber and its interactions with the penton base. These observations resolve the previous conflicting assignments of the minor proteins and suggest the likely conservation of their organization across different HAdVs.

  13. Tracking influence between naive Bayes models using score-based structure learning

    CSIR Research Space (South Africa)

    Ajoodha, R

    2017-11-01

    Full Text Available Current structure learning practices in Bayesian networks have been developed to learn the structure between observable variables and learning latent parameters independently. One exception establishes a variant of EM for learning the structure...

  14. Base isolation strategies for structures and components

    International Nuclear Information System (INIS)

    Varma, Veto; Reddy, G.R.; Vaze, K.K.; Kushwaha, H.S.

    2003-08-01

    In the present report the effect of laminated rubber bearing (LRB) system on the dynamic response of the structure was studied. A LRB system was designed and tested in the laboratory for its dynamic characteristics. Finite element analysis was also performed and based on this analysis, isolator for PHWR nuclear power plant was designed. Analysis of the building was performed with and without isolator. Comparison of responses was made in terms of frequencies, accelerations and displacements and floor response spectra. (author)

  15. Study of methane solubility in oil base used in oil base drilling fluid; Estudo da solubilidade de metano em base oleo utilizada em fluido de perfuracao base oleo

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Carolina Teixeira da; Mariolani, Jose Ricardo Lenzi [Universidade Estadual de Campinas, SP (Brazil); Ribeiro, Paulo Roberto; Lomba, Rosana Fatima Teixeira; Bonet, Euclides Jose

    2004-07-01

    During drilling a well, it is necessary to prevent and control high pressurized zones because while drilling on those zones, could occur a kick if the formation pressure were higher then downhole pressure, allowing the entering of undesirables fluids from the formation to the wellbore. If the well is not controlled this kick could became a blowout, generating damages to the environment, to the equipment and the human life. When drilling using oil-based mud, the concern related to the well control would be higher due the gas solubility in the mud, which could make it hard to detect the kick, especially in deep and ultra deep waters. In this work we have studied the interaction between methane and organic liquids used in drilling fluids, and the measurement and analysis of the thermodynamic properties of those gas liquid mixtures. There have been measured parameters like the oil formation volume factor (FVF{sub o}), bubble pressure, solubility (Rs) and the density of the saturated liquid in function of methane mole fraction and temperature. The results have shown that the gas solubility, at downhole conditions and during kick circulation, is a factor very important to the safety during well drilling in deep and ultra deep waters. (author)

  16. Bioinspired twisted composites based on Bouligand structures

    Science.gov (United States)

    Pinto, F.; Iervolino, O.; Scarselli, G.; Ginzburg, D.; Meo, M.

    2016-04-01

    The coupling between structural support and protection makes biological systems an important source of inspiration for the development of advanced smart composite structures. In particular, some particular material configurations can be implemented into traditional composites in order to improve their impact resistance and the out-of-plane properties, which represents one of the major weakness of commercial carbon fibres reinforced polymers (CFRP) structures. Based on this premise, a three-dimensional twisted arrangement shown in a vast multitude of biological systems (such as the armoured cuticles of Scarabei, the scales of Arapaima Gigas and the smashing club of Odontodactylus Scyllarus) has been replicated to develop an improved structural material characterised by a high level of in-plane isotropy and a higher interfacial strength generated by the smooth stiffness transition between each layer of fibrils. Indeed, due to their intrinsic layered nature, interlaminar stresses are one of the major causes of failure of traditional CFRP and are generated by the mismatch of the elastic properties between plies in a traditional laminate. Since the energy required to open a crack or a delamination between two adjacent plies is due to the difference between their orientations, the gradual angle variation obtained by mimicking the Bouligand Structures could improve energy absorption and the residual properties of carbon laminates when they are subjected to low velocity impact event. Two different bioinspired laminates were manufactured following a double helicoidal approach and a rotational one and were subjected to a complete test campaign including low velocity impact loading and compared to a traditional quasi-isotropic panel. Fractography analysis via X-Ray tomography was used to understand the mechanical behaviour of the different laminates and the residual properties were evaluated via Compression After Impact (CAI) tests. Results confirmed that the biological

  17. Protein structure based prediction of catalytic residues.

    Science.gov (United States)

    Fajardo, J Eduardo; Fiser, Andras

    2013-02-22

    Worldwide structural genomics projects continue to release new protein structures at an unprecedented pace, so far nearly 6000, but only about 60% of these proteins have any sort of functional annotation. We explored a range of features that can be used for the prediction of functional residues given a known three-dimensional structure. These features include various centrality measures of nodes in graphs of interacting residues: closeness, betweenness and page-rank centrality. We also analyzed the distance of functional amino acids to the general center of mass (GCM) of the structure, relative solvent accessibility (RSA), and the use of relative entropy as a measure of sequence conservation. From the selected features, neural networks were trained to identify catalytic residues. We found that using distance to the GCM together with amino acid type provide a good discriminant function, when combined independently with sequence conservation. Using an independent test set of 29 annotated protein structures, the method returned 411 of the initial 9262 residues as the most likely to be involved in function. The output 411 residues contain 70 of the annotated 111 catalytic residues. This represents an approximately 14-fold enrichment of catalytic residues on the entire input set (corresponding to a sensitivity of 63% and a precision of 17%), a performance competitive with that of other state-of-the-art methods. We found that several of the graph based measures utilize the same underlying feature of protein structures, which can be simply and more effectively captured with the distance to GCM definition. This also has the added the advantage of simplicity and easy implementation. Meanwhile sequence conservation remains by far the most influential feature in identifying functional residues. We also found that due the rapid changes in size and composition of sequence databases, conservation calculations must be recalibrated for specific reference databases.

  18. Bases do pensamento fenomenológico e existencial em William James

    Directory of Open Access Journals (Sweden)

    Ana Maria Lopez Calvo de Feijoo

    Full Text Available Neste artigo, temos por objetivo investigar os fundamentos e as bases do pensamento fenomenológico e existencial advindos da Psicologia de William James no que diz respeito à noção de consciência, método e prática clínica. Para tanto, analisamos algumas obras de James e dividimos as suas propostas em três momentos distintos: pragmatismo, funcionalismo e empirismo. Por meio das elaborações em cada um desses momentos, tentamos esclarecer os pontos de encontro e os pontos de desencontro com os pensamentos fenomenológico e existencial. Concluímos que o ponto de encontro diz respeito à tentativa de não objetivação da consciência. Quanto ao desencontro, consideramos que James ainda toma a consciência como objeto da Psicologia e que a fenomenologia e as perspectivas existenciais se afastam da ideia de objeto, uma vez que não consideram a consciência contraposta ao mundo. Outro desencontro apresenta-se na acentuada divergência entre James e o pensamento fenomenológico e existencial no que se refere ao método e à prática bem como aos objetivos da clínica.

  19. Emergency Medical Service (EMS) Stations

    Data.gov (United States)

    Kansas Data Access and Support Center — EMS Locations in Kansas The EMS stations dataset consists of any location where emergency medical services (EMS) personnel are stationed or based out of, or where...

  20. O Mestrado do Programa de Pós-graduação em Epidemiologia da UFPel baseado em consórcio de pesquisa: uma experiência inovadora UFPel's epidemiology MSc program based on research consortium: an innovative experience

    Directory of Open Access Journals (Sweden)

    Aluísio J. D. Barros

    2008-05-01

    Full Text Available O Programa de Pós-graduação em Epidemiologia da UFPel realizou um intenso trabalho de auto-avaliação para resolver problemas identificados com seu curso de mestrado. O resultado foi a introdução de uma estrutura curricular baseada em dois pilares. De um lado, disciplinas de cunho teórico, fornecendo a base da formação do mestrando; de outro, disciplinas de cunho prático, onde os alunos trabalham coletivamente a construção de seu projeto de pesquisa, passando pela escolha de um tema, revisão da literatura, definição de objetivos e da metodologia. Esse esforço conjunto culmina na realização de um trabalho de campo único, na forma de um estudo transversal de base populacional, em que todos os mestrandos participam de maneira integral, obtendo dados para sua dissertação. Essa estratégia tem garantido a formação de mestres em epidemiologia com forte base teórica e com experiência de preparação e condução de um trabalho de campo. Além disso, tem sido possível manter um tempo de titulação abaixo de 24 meses. Cerca de 80% dos egressos têm publicado pelo menos um artigo baseado em seu mestrado. Destas publicações, quase 90% têm se dado em periódicos classificados como Internacional-A no Qualis da Capes.The postgraduate program in epidemiology of the Federal University of Pelotas, Brazil, went through an intense self-assessment process to solve problems related to its Master's course. The result was the introduction of a curricular structure based on two pillars. The first one: theoretical courses to offer students the bases of epidemiology. The other, practical training in which students work in groups to design their research projects, from the choice of a research question, to literature review, definition of objectives and methods. This joint effort leads to shared fieldwork, a cross-sectional population-based study, where all students have full participation and get data for their dissertations. This strategy

  1. 7.5-Å cryo-em structure of the mycobacterial fatty acid synthase.

    Science.gov (United States)

    Boehringer, Daniel; Ban, Nenad; Leibundgut, Marc

    2013-03-11

    The mycobacterial fatty acid synthase (FAS) complex is a giant 2.0-MDa α(6) homohexameric multifunctional enzyme that catalyzes synthesis of fatty acid precursors of mycolic acids, which are major components of the cell wall in Mycobacteria and play an important role in pathogenicity. Here, we present a three-dimensional reconstruction of the Mycobacterium smegmatis FAS complex at 7.5Å, highly homologous to the Mycobacterium tuberculosis multienzyme, by cryo-electron microscopy. Based on the obtained structural data, which allowed us to identify secondary-structure elements, and sequence homology with the fungal FAS, we generated an accurate architectural model of the complex. The FAS system from Mycobacteria resembles a minimized version of the fungal FAS with much larger openings in the reaction chambers. These architectural features of the mycobacterial FAS may be important for the interaction with mycolic acid processing and condensing enzymes that further modify the precursors produced by FAS and for autoactivation of the FAS complex. Copyright © 2012 Elsevier Ltd. All rights reserved.

  2. Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1.

    Science.gov (United States)

    Su, Qiang; Hu, Feizhuo; Liu, Yuxia; Ge, Xiaofei; Mei, Changlin; Yu, Shengqiang; Shen, Aiwen; Zhou, Qiang; Yan, Chuangye; Lei, Jianlin; Zhang, Yanqing; Liu, Xiaodong; Wang, Tingliang

    2018-03-22

    PKD2L1, also termed TRPP3 from the TRPP subfamily (polycystic TRP channels), is involved in the sour sensation and other pH-dependent processes. PKD2L1 is believed to be a nonselective cation channel that can be regulated by voltage, protons, and calcium. Despite its considerable importance, the molecular mechanisms underlying PKD2L1 regulations are largely unknown. Here, we determine the PKD2L1 atomic structure at 3.38 Å resolution by cryo-electron microscopy, whereby side chains of nearly all residues are assigned. Unlike its ortholog PKD2, the pore helix (PH) and transmembrane segment 6 (S6) of PKD2L1, which are involved in upper and lower-gate opening, adopt an open conformation. Structural comparisons of PKD2L1 with a PKD2-based homologous model indicate that the pore domain dilation is coupled to conformational changes of voltage-sensing domains (VSDs) via a series of π-π interactions, suggesting a potential PKD2L1 gating mechanism.

  3. Tungsten - Yttrium Based Nuclear Structural Materials

    Science.gov (United States)

    Ramana, Chintalapalle; Chessa, Jack; Martinenz, Gustavo

    2013-04-01

    The challenging problem currently facing the nuclear science community in this 21st century is design and development of novel structural materials, which will have an impact on the next-generation nuclear reactors. The materials available at present include reduced activation ferritic/martensitic steels, dispersion strengthened reduced activation ferritic steels, and vanadium- or tungsten-based alloys. These materials exhibit one or more specific problems, which are either intrinsic or caused by reactors. This work is focussed towards tungsten-yttrium (W-Y) based alloys and oxide ceramics, which can be utilized in nuclear applications. The goal is to derive a fundamental scientific understanding of W-Y-based materials. In collaboration with University of Califonia -- Davis, the project is designated to demonstrate the W-Y based alloys, ceramics and composites with enhanced physical, mechanical, thermo-chemical properties and higher radiation resistance. Efforts are focussed on understanding the microstructure, manipulating materials behavior under charged-particle and neutron irradiation, and create a knowledge database of defects, elemental diffusion/segregation, and defect trapping along grain boundaries and interfaces. Preliminary results will be discussed.

  4. Using high-order polynomial basis in 3-D EM forward modeling based on volume integral equation method

    Science.gov (United States)

    Kruglyakov, Mikhail; Kuvshinov, Alexey

    2018-05-01

    3-D interpretation of electromagnetic (EM) data of different origin and scale becomes a common practice worldwide. However, 3-D EM numerical simulations (modeling)—a key part of any 3-D EM data analysis—with realistic levels of complexity, accuracy and spatial detail still remains challenging from the computational point of view. We present a novel, efficient 3-D numerical solver based on a volume integral equation (IE) method. The efficiency is achieved by using a high-order polynomial (HOP) basis instead of the zero-order (piecewise constant) basis that is invoked in all routinely used IE-based solvers. We demonstrate that usage of the HOP basis allows us to decrease substantially the number of unknowns (preserving the same accuracy), with corresponding speed increase and memory saving.

  5. Efeito da suplementação enzimática de dietas à base de centeio em diferentes períodos do ciclo produtivo nas performances dos frangos de carne

    OpenAIRE

    Santos, Carina Alexandra Infante dos

    2008-01-01

    Mestrado em Engenharia Zootécnica - Produção Animal - Instituto Superior de Agronomia Plant cell walls are complex structures, whose main constituents are non-starch polysaccharides. The monogastric animal does not produce enzymes capable of degrading these structural polysaccharides and therefore, a low level of cereals may be used. The incorporation of exogenous enzymes gained increasing importance. In this study five rye-based treatments were used, where the only variable wa...

  6. Modelo de oposições múltiplas modificado: abordagem baseada em traços distintivos Modified multiple oppositions' model: approach based on distinctive features

    Directory of Open Access Journals (Sweden)

    Karina Carlesso Pagliarin

    2009-01-01

    Full Text Available O objetivo deste trabalho foi propor uma abordagem com enfoque em traços distintivos para o Modelo de Oposições Múltiplas e testar sua aplicação em um sujeito falante do Português Brasileiro. O Modelo foi aplicado em um sujeito do sexo masculino, com desvio fonológico moderado-severo e idade de seis anos e meio. Após avaliação fonológica, procedeu-se à seleção dos sons-alvo. Considerou-se o sistema fonológico inicial, bem como os traços distintivos alterados ([+voz], [+soante], [+aproximante], [coronal/±anterior], [-contínuo]. Os traços com maior número de alterações eram [+voz, +soante, +aproximante], justificando a escolha dos seguintes sons-alvo para tratamento: /r/ x /l/ x // x // x /z/, em onset medial.Tendo como base a aplicação desse modelo em falantes do inglês, percebeu-se a necessidade de introduzir alguns procedimentos, como: a escolha dos sons-alvo a partir dos traços distintivos alterados e a estrutura da sessão terapêutica. Ao final, o sujeito foi reavaliado a fim de verificar as aquisições no sistema fonológico. Após dez sessões de fonoterapia,o sujeito adquiriu os fonemas /l, , , z/, generalizando-os para outras posições na palavra (/Z/ e /l/ em onset inicial. Verificou-se, também, a ocorrência de generalização para a mesma classe e para outras classes de sons (/b/, /d/, /g/, /v/. No entanto, o fonema /r/ não foi adquirido. Esta proposta mostrou-se efetiva, pois o sujeito apresentou melhora em seu sistema fonológico com poucas sessões terapêuticas. Pôde-se observar que o Modelo de Oposições Múltiplas, utilizando a abordagem com base em traços distintivos é eficaz, pois favoreceu diversas mudanças fonológicas.The aim of this study was to propose an approach based on distinctive features for the Multiple Oppositions Model, and to test its application on a Brazilian Portuguese speaker. The model was used with a male subject with moderate-severe phonological disorder and six years

  7. Vision based condition assessment of structures

    International Nuclear Information System (INIS)

    Uhl, Tadeusz; Kohut, Piotr; Holak, Krzysztof; Krupinski, Krzysztof

    2011-01-01

    In this paper, a vision-based method for measuring a civil engineering construction's in-plane deflection curves is presented. The displacement field of the analyzed object which results from loads was computed by means of a digital image correlation coefficient. Image registration techniques were introduced to increase the flexibility of the method. The application of homography mapping enabled the deflection field to be computed from two images of the structure, acquired from two different points in space. An automatic shape filter and a corner detector were implemented to calculate the homography mapping between the two views. The developed methodology, created architecture and the capabilities of software tools, as well as experimental results obtained from tests made on a lab set-up and civil engineering constructions, are discussed.

  8. Vision based condition assessment of structures

    Energy Technology Data Exchange (ETDEWEB)

    Uhl, Tadeusz; Kohut, Piotr; Holak, Krzysztof; Krupinski, Krzysztof, E-mail: tuhl@agh.edu.pl, E-mail: pko@agh.edu.pl, E-mail: holak@agh.edu.pl, E-mail: krzysiek.krupinski@wp.pl [Department of Robotics and Mechatronics, AGH-University of Science and Technology, Al.Mickiewicza 30, 30-059 Cracow (Poland)

    2011-07-19

    In this paper, a vision-based method for measuring a civil engineering construction's in-plane deflection curves is presented. The displacement field of the analyzed object which results from loads was computed by means of a digital image correlation coefficient. Image registration techniques were introduced to increase the flexibility of the method. The application of homography mapping enabled the deflection field to be computed from two images of the structure, acquired from two different points in space. An automatic shape filter and a corner detector were implemented to calculate the homography mapping between the two views. The developed methodology, created architecture and the capabilities of software tools, as well as experimental results obtained from tests made on a lab set-up and civil engineering constructions, are discussed.

  9. Lagrangian based methods for coherent structure detection

    Energy Technology Data Exchange (ETDEWEB)

    Allshouse, Michael R., E-mail: mallshouse@chaos.utexas.edu [Center for Nonlinear Dynamics and Department of Physics, University of Texas at Austin, Austin, Texas 78712 (United States); Peacock, Thomas, E-mail: tomp@mit.edu [Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

    2015-09-15

    There has been a proliferation in the development of Lagrangian analytical methods for detecting coherent structures in fluid flow transport, yielding a variety of qualitatively different approaches. We present a review of four approaches and demonstrate the utility of these methods via their application to the same sample analytic model, the canonical double-gyre flow, highlighting the pros and cons of each approach. Two of the methods, the geometric and probabilistic approaches, are well established and require velocity field data over the time interval of interest to identify particularly important material lines and surfaces, and influential regions, respectively. The other two approaches, implementing tools from cluster and braid theory, seek coherent structures based on limited trajectory data, attempting to partition the flow transport into distinct regions. All four of these approaches share the common trait that they are objective methods, meaning that their results do not depend on the frame of reference used. For each method, we also present a number of example applications ranging from blood flow and chemical reactions to ocean and atmospheric flows.

  10. Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-Å resolution.

    Science.gov (United States)

    Quade, Nick; Boehringer, Daniel; Leibundgut, Marc; van den Heuvel, Joop; Ban, Nenad

    2015-07-08

    Hepatitis C virus (HCV), a widespread human pathogen, is dependent on a highly structured 5'-untranslated region of its mRNA, referred to as internal ribosome entry site (IRES), for the translation of all of its proteins. The HCV IRES initiates translation by directly binding to the small ribosomal subunit (40S), circumventing the need for many eukaryotic translation initiation factors required for mRNA scanning. Here we present the cryo-EM structure of the human 40S ribosomal subunit in complex with the HCV IRES at 3.9 Å resolution, determined by focused refinement of an 80S ribosome-HCV IRES complex. The structure reveals the molecular details of the interactions between the IRES and the 40S, showing that expansion segment 7 (ES7) of the 18S rRNA acts as a central anchor point for the HCV IRES. The structural data rationalizes previous biochemical and genetic evidence regarding the initiation mechanism of the HCV and other related IRESs.

  11. Cryo-EM structures of two bovine adenovirus type 3 intermediates

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Lingpeng; Huang, Xiaoxing; Li, Xiaomin [National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 (China); Xiong, Wei [State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Luo-jia-shan, Wuhan, Hubei 430072 (China); Sun, Wei; Yang, Chongwen; Zhang, Kai; Wang, Ying [National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 (China); Liu, Hongrong [College of Physics and Information Science, Hunan Normal University, Changsha, Hunan 410081 (China); Huang, Xiaojun; Ji, Gang; Sun, Fei [National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 (China); Zheng, Congyi, E-mail: cctcc202@whu.edu.cn [State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Luo-jia-shan, Wuhan, Hubei 430072 (China); Zhu, Ping, E-mail: zhup@ibp.ac.cn [National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 (China)

    2014-02-15

    Adenoviruses (Ads) infect hosts from all vertebrate species and have been investigated as vaccine vectors. We report here near-atomic structures of two bovine Ad type 3 (BAd3) intermediates obtained by cryo-electron microscopy. A comparison between the two intermediate structures reveals that the differences are localized in the fivefold vertex region, while their facet structures are identical. The overall facet structure of BAd3 exhibits a similar structure to human Ads; however, BAd3 protein IX has a unique conformation. Mass spectrometry and cryo-electron tomography analyses indicate that one intermediate structure represents the stage during DNA encapsidation, whilst the other intermediate structure represents a later stage. These results also suggest that cleavage of precursor protein VI occurs during, rather than after, the DNA encapsidation process. Overall, our results provide insights into the mechanism of Ad assembly, and allow the first structural comparison between human and nonhuman Ads at backbone level. - Highlights: • First structure of bovine adenovirus type 3. • Some channels are located at the vertex of intermediate during DNA encapsidation. • Protein IX exhibits a unique conformation of trimeric coiled–coiled structure. • Cleavage of precursor protein VI occurs during the DNA encapsidation process.

  12. Cryo-EM structures of two bovine adenovirus type 3 intermediates

    International Nuclear Information System (INIS)

    Cheng, Lingpeng; Huang, Xiaoxing; Li, Xiaomin; Xiong, Wei; Sun, Wei; Yang, Chongwen; Zhang, Kai; Wang, Ying; Liu, Hongrong; Huang, Xiaojun; Ji, Gang; Sun, Fei; Zheng, Congyi; Zhu, Ping

    2014-01-01

    Adenoviruses (Ads) infect hosts from all vertebrate species and have been investigated as vaccine vectors. We report here near-atomic structures of two bovine Ad type 3 (BAd3) intermediates obtained by cryo-electron microscopy. A comparison between the two intermediate structures reveals that the differences are localized in the fivefold vertex region, while their facet structures are identical. The overall facet structure of BAd3 exhibits a similar structure to human Ads; however, BAd3 protein IX has a unique conformation. Mass spectrometry and cryo-electron tomography analyses indicate that one intermediate structure represents the stage during DNA encapsidation, whilst the other intermediate structure represents a later stage. These results also suggest that cleavage of precursor protein VI occurs during, rather than after, the DNA encapsidation process. Overall, our results provide insights into the mechanism of Ad assembly, and allow the first structural comparison between human and nonhuman Ads at backbone level. - Highlights: • First structure of bovine adenovirus type 3. • Some channels are located at the vertex of intermediate during DNA encapsidation. • Protein IX exhibits a unique conformation of trimeric coiled–coiled structure. • Cleavage of precursor protein VI occurs during the DNA encapsidation process

  13. Redução de fósforo em dietas para frangos com base em valores de equivalência da fitase

    Directory of Open Access Journals (Sweden)

    Luciana de Paula Naves

    2014-01-01

    Full Text Available O objetivo deste trabalho foi avaliar o uso de valores de equivalência da fitase como base para redução de fósforo disponível (P-disp em dietas para frangos. Foram avaliados dez planos nutricionais com seis repetições de 15 aves cada uma. Avaliaram-se: desempenho, teor de cinzas na tíbia e custo da ração. De 1 a 7 e de 36 a 42 dias de idade, as aves receberam dieta basal; de 8 a 21 dias, dieta sem fitase contendo 3,9 g kg-1 de P-disp e quatro dietas com fitase contendo de 1,1 a 2,5 g kg-1 de P-disp; e de 22 a 35 dias, dieta sem fitase contendo 3,4 g kg-1 de P-disp mais dieta com fitase contendo 1,6 g kg-1 de P-disp. O melhor plano nutricional foi composto pelas dietas: 4,7 g kg-1 de P-disp sem fitase (1 a 7 dias; 2,0 g kg-1 de P-disp suplementada com fitase (8 a 21 dias; 3,4 g kg-1 de P-disp em ração sem fitase (22 a 35 dias; e 3,0 g kg-1 de P-disp em ração sem fitase (36 a 42 dias. A redução do P-disp ocorre no período de 8 a 21 dias de idade e corresponde a 2,0 g kg-1 de ração suplementada com fitase.

  14. Structure-Based Algorithms for Microvessel Classification

    KAUST Repository

    Smith, Amy F.

    2015-02-01

    © 2014 The Authors. Microcirculation published by John Wiley & Sons Ltd. Objective: Recent developments in high-resolution imaging techniques have enabled digital reconstruction of three-dimensional sections of microvascular networks down to the capillary scale. To better interpret these large data sets, our goal is to distinguish branching trees of arterioles and venules from capillaries. Methods: Two novel algorithms are presented for classifying vessels in microvascular anatomical data sets without requiring flow information. The algorithms are compared with a classification based on observed flow directions (considered the gold standard), and with an existing resistance-based method that relies only on structural data. Results: The first algorithm, developed for networks with one arteriolar and one venular tree, performs well in identifying arterioles and venules and is robust to parameter changes, but incorrectly labels a significant number of capillaries as arterioles or venules. The second algorithm, developed for networks with multiple inlets and outlets, correctly identifies more arterioles and venules, but is more sensitive to parameter changes. Conclusions: The algorithms presented here can be used to classify microvessels in large microvascular data sets lacking flow information. This provides a basis for analyzing the distinct geometrical properties and modelling the functional behavior of arterioles, capillaries, and venules.

  15. SUMMARY OF 2010 DOE EM INTERNATIONAL PROGRAM STUDIES OF WASTE GLASS STRUCTURE AND PROPERTIES

    Energy Technology Data Exchange (ETDEWEB)

    Fox, K.; Choi, A.; Marra, J.; Billings, A.

    2011-02-07

    Collaborative work between the Savannah River National Laboratory (SRNL) and SIA Radon in Russia was divided among three tasks for calendar year 2010. The first task focused on the study of simplified high level waste glass compositions with the objective of identifying the compositional drivers that lead to crystallization and poor chemical durability. The second task focused on detailed characterization of more complex waste glass compositions with unexpectedly poor chemical durabilities. The third task focused on determining the structure of select high level waste glasses made with varying frit compositions in order to improve models under development for predicting the melt rate of the Defense Waste Processing Facility (DWPF) glasses. The majority of these tasks were carried out at SIA Radon. Selection and fabrication of the glass compositions, along with chemical composition measurements and evaluations of durability were carried out at SRNL and are described in this report. SIA Radon provided three summary reports based on the outcome of the three tasks. These reports are included as appendices to this document. Briefly, the result of characterization of the Task 1 glasses may indicate that glass compositions where iron is predominantly tetrahedrally coordinated have more of a tendency to crystallize nepheline or nepheline-like phases. For the Task 2 glasses, the results suggested that the relatively low fraction of tetrahedrally coordinated boron and the relatively low concentrations of Al{sub 2}O{sub 3} available to form [BO{sub 4/2}]{sup -}Me{sup +} and [AlO{sub 4/2}]{sup -}Me{sup +} tetrahedral units are not sufficient to consume all of the alkali ions, and thus these alkali ions are easily leached from the glasses. All of the twelve Task 3 glass compositions were determined to be mainly amorphous, with some minor spinel phases. Several key structural units such as metasilicate chains and rings were identified, which confirms the current modeling

  16. Low Diversity Bacterial Community and the Trapping Activity of Metabolites from Cultivable Bacteria Species in the Female Reproductive System of the Oriental Fruit Fly, <em>Bactrocera dorsalisem> Hendel (Diptera: Tephritidae

    Directory of Open Access Journals (Sweden)

    Hongyu Zhang

    2012-05-01

    Full Text Available Our goal was to identify the bacteria inhabiting the reproductive system of the female oriental fruit fly, <em>Bactrocera dorsalisem> (Hendel, and evaluate the chemotaxis of <em>B>. <em>dorsalis> to the metabolites produced by the bacteria. Based on 16S rRNA-based polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE, 18 operational taxonomic units (OTUs were assigned to the five bacterial classes <em>Betaproteobacteria>, <em>Alphaproteobacteria>, <em>Gammaproteobacteria>, <em>Bacilli> and <em>Actinobacteria>. Nine OTUs were assigned to <em>Gammaproteobacteria>, which was the most highly represented class. <em>Enterobacteriaceae> constituted the dominant family, and within this family, three genera and five species were identified, including <em>Enterobacter sakazakiiem>, <em>Klebsiella> <em>oxytoca>, <em>Klebsiella> <em>pneumoniae,> Raoultellaem> <em>terrigena em>and <em>Enterobacter> <em>amnigenus>. In this set, the first two species were the dominant components, and the latter three species were the minor ones. Finally, we found that the metabolites produced by <em>R.> terrigenaem>, <em>K. oxytocaem> and <em>K.> pneumoniae em>were attractive to the <em>B.> dorsalisem> adults, and in field studies, <em>B.> dorsalisem> adults were most attracted to <em>K.> oxytocaem>. Collectively, our results suggest that the female reproductive system plays an important role in the transfer of enterobacteria from the gut to fruit. Our data may prompt the development of a female-targeted population control strategy for this fly.

  17. Structure-based characterization of multiprotein complexes.

    Science.gov (United States)

    Wiederstein, Markus; Gruber, Markus; Frank, Karl; Melo, Francisco; Sippl, Manfred J

    2014-07-08

    Multiprotein complexes govern virtually all cellular processes. Their 3D structures provide important clues to their biological roles, especially through structural correlations among protein molecules and complexes. The detection of such correlations generally requires comprehensive searches in databases of known protein structures by means of appropriate structure-matching techniques. Here, we present a high-speed structure search engine capable of instantly matching large protein oligomers against the complete and up-to-date database of biologically functional assemblies of protein molecules. We use this tool to reveal unseen structural correlations on the level of protein quaternary structure and demonstrate its general usefulness for efficiently exploring complex structural relationships among known protein assemblies. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  18. Semiconductor wire array structures, and solar cells and photodetectors based on such structures

    Science.gov (United States)

    Kelzenberg, Michael D.; Atwater, Harry A.; Briggs, Ryan M.; Boettcher, Shannon W.; Lewis, Nathan S.; Petykiewicz, Jan A.

    2014-08-19

    A structure comprising an array of semiconductor structures, an infill material between the semiconductor materials, and one or more light-trapping elements is described. Photoconverters and photoelectrochemical devices based on such structure also described.

  19. Reliability-Based Optimization of Structural Elements

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    In this paper structural elements from an optimization point of view are considered, i.e. only the geometry of a structural element is optimized. Reliability modelling of the structural element is discussed both from an element point of view and from a system point of view. The optimization...

  20. SDSL-ESR-based protein structure characterization

    NARCIS (Netherlands)

    Strancar, J.; Kavalenka, A.A.; Urbancic, I.; Ljubetic, A.; Hemminga, M.A.

    2010-01-01

    As proteins are key molecules in living cells, knowledge about their structure can provide important insights and applications in science, biotechnology, and medicine. However, many protein structures are still a big challenge for existing high-resolution structure-determination methods, as can be

  1. Gas inflow in oil base fluids; Influxo de gas em fluidos a base de oleo

    Energy Technology Data Exchange (ETDEWEB)

    Lazaro, Welmar [PETROBRAS, Rio de Janeiro (Brazil). Dept. de Perfuracao. Div. de Fluidos de Perfuracao; Boas, Mario Barbosa V [PETROBRAS, Rio de Janeiro (Brazil). Centro de Pesquisas. Div. de Explotacao

    1990-12-31

    One of the major problems related to the use of oil base fluids is the dissolution of the natural gas in the fluid. This paper attempts initially at making a bibliographical review of all that was written on the subject of drilling fluids up to now. It also mentions some theoretical aspects regarding the process of gas dissolution in diesel oils, in order to produce an understanding of how the dissolution mechanism is processed. For a same increase in measured volume on the surface, the amount of gas incorporated into the fluid is significantly larger if the gas is dissolved in the oil phase than if it is emulsified in the fluid, as occurs when the fluid is water base. A rig team used to working with water-base fluids may be surprised with the fact that an increase of 20 bbl of fluid on the surface of a 5000 m well can mean the incorporation of about 1800 m{sup 3} of gas, if the fluid is oil-base and all the gas is in solution instead of the incorporation of 900 m{sup 3} if the fluid is water base. This paper has the goal of warning drilling engineers and technicians about this problem, as well as presenting charts and equations that allow for a more realistic evaluation of the amount of gas incorporated into oil fluids. (author) 16 refs., 7 figs., 2 tabs.

  2. Constituents from <em>Vigna em>vexillata> and Their Anti-Inflammatory Activity

    Directory of Open Access Journals (Sweden)

    Guo-Feng Chen

    2012-08-01

    Full Text Available The seeds of <em>Vigna em>genus are important food resources and there have already been many reports regarding their bioactivities. In our preliminary bioassay, the chloroform layer of methanol extracts of<em> V. vexillata em>demonstrated significant anti-inflammatory bioactivity. Therefore, the present research is aimed to purify and identify the anti-inflammatory principles of <em>V. vexillataem>. One new sterol (1 and two new isoflavones (2,3 were reported from the natural sources for the first time and their chemical structures were determined by the spectroscopic and mass spectrometric analyses. In addition, 37 known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. Among the isolates, daidzein (23, abscisic acid (25, and quercetin (40 displayed the most significant inhibition of superoxide anion generation and elastase release.

  3. Earnings with Condition Based Maintenance; Ganhos com manutencao preditiva baseada em dados de processo em tempo real

    Energy Technology Data Exchange (ETDEWEB)

    Barabas, Elizabeth [Softbrasil Automacao, Sao Paulo, SP (Brazil)

    2008-07-01

    Keeping active in perfect functioning is essential for any company. Today, the maintenance has been performed in most of the stops for maintenance. In a modern industrial environment, where the systems provide data and process information in real time, it is possible bring the performance of the plant to a optimized level, through the maintenance based on condition of equipment. This work described the earnings with CBM (Condition Based Maintenance)

  4. Aluminium based amorphous and nanocrystalline structure

    Energy Technology Data Exchange (ETDEWEB)

    Sitek, Jozef; Degmova, Jarmila, E-mail: jarmila.degmova@stuba.sk [Slovak University of Technology, Department of Nuclear Physics and Technology, Faculty of Electrical Engineering and Information Technology (Slovakia)

    2005-09-15

    Aluminium based rapidly quenched alloys of nominal composition Al{sub 90}Fe{sub 7}Nb{sub 3} and Al{sub 94}Fe{sub 2}V{sub 4} were studied by Moessbauer spectroscopy. Samples annealed up to 573 K showed amorphous structure represented by quadrupole doublet. From corrected spectra areas the values of f-factor were calculated. In the case of AlFeNb samples f-factor was estimated as f = 0.26 and for AlFeV f = 0.31. The corresponding Debye temperatures were also calculated. Higher temperature annealing at 773 and 873 K induced deformation of nano- and microcrystalline state. Moessbauer spectra of samples of both compositions (with vanadium as well as with niobium) annealed at 773 K showed superposition of crystalline phases with dominant role of Al{sub 3}Fe alloy. During annealing at 873 K, phases with large grains and small amount of FeAl metastable phase were developed (Das et al. Mat. Sci. Eng., A304-A306, 159, 2001; Illekova et al. Mat. Sci. Eng., A375-A377, 946, 2004).

  5. Aluminium based amorphous and nanocrystalline structure

    International Nuclear Information System (INIS)

    Sitek, Jozef; Degmova, Jarmila

    2005-01-01

    Aluminium based rapidly quenched alloys of nominal composition Al 90 Fe 7 Nb 3 and Al 94 Fe 2 V 4 were studied by Moessbauer spectroscopy. Samples annealed up to 573 K showed amorphous structure represented by quadrupole doublet. From corrected spectra areas the values of f-factor were calculated. In the case of AlFeNb samples f-factor was estimated as f = 0.26 and for AlFeV f = 0.31. The corresponding Debye temperatures were also calculated. Higher temperature annealing at 773 and 873 K induced deformation of nano- and microcrystalline state. Moessbauer spectra of samples of both compositions (with vanadium as well as with niobium) annealed at 773 K showed superposition of crystalline phases with dominant role of Al 3 Fe alloy. During annealing at 873 K, phases with large grains and small amount of FeAl metastable phase were developed (Das et al. Mat. Sci. Eng., A304-A306, 159, 2001; Illekova et al. Mat. Sci. Eng., A375-A377, 946, 2004).

  6. SDSL-ESR-based protein structure characterization.

    Science.gov (United States)

    Strancar, Janez; Kavalenka, Aleh; Urbancic, Iztok; Ljubetic, Ajasja; Hemminga, Marcus A

    2010-03-01

    As proteins are key molecules in living cells, knowledge about their structure can provide important insights and applications in science, biotechnology, and medicine. However, many protein structures are still a big challenge for existing high-resolution structure-determination methods, as can be seen in the number of protein structures published in the Protein Data Bank. This is especially the case for less-ordered, more hydrophobic and more flexible protein systems. The lack of efficient methods for structure determination calls for urgent development of a new class of biophysical techniques. This work attempts to address this problem with a novel combination of site-directed spin labelling electron spin resonance spectroscopy (SDSL-ESR) and protein structure modelling, which is coupled by restriction of the conformational spaces of the amino acid side chains. Comparison of the application to four different protein systems enables us to generalize the new method and to establish a general procedure for determination of protein structure.

  7. A Limited Structural Modification Results in a Significantly More Efficacious Diazachrysene-Based Filovirus Inhibitor

    Directory of Open Access Journals (Sweden)

    Rekha G. Panchal

    2012-08-01

    Full Text Available Ebola (EBOV and Marburg (MARV filoviruses are highly infectious pathogens causing deadly hemorrhagic fever in humans and non-human primates. Promising vaccine candidates providing immunity against filoviruses have been reported. However, the sporadic nature and swift progression of filovirus disease underlines the need for the development of small molecule therapeutics providing immediate antiviral effects. Herein we describe a brief structural exploration of two previously reported diazachrysene (DAAC-based EBOV inhibitors. Specifically, three analogs were prepared to examine how slight substituent modifications would affect inhibitory efficacy and inhibitor-mediated toxicity during not only EBOV, but also MARV cellular infection. Of the three analogs, one was highly efficacious, providing IC50 values of 0.696 µM ± 0.13 µM and 2.76 µM ± 0.21 µM against EBOV and MARV infection, respectively, with little or no associated cellular toxicity. Overall, the structure-activity and structure-toxicity results from this study provide a framework for the future development of DAAC-based filovirus inhibitors that will be both active and non-toxic <em>in vivoem>.

  8. Engenharia de Avaliações com Base em Modelos Gamlss

    OpenAIRE

    de Araújo Florencio, Lutemberg

    2010-01-01

    A determinação técnica do valor de um bem imóvel (casas, terrenos, entre outros) é de extrema importância para a tomada de decisão em diversos segmentos da sociedade e em muitos órgãos governamentais e privados. Cabe à Engenharia de Avaliações, enquanto ciência do valor, coletar, tratar e analisar dados e estimar modelos que expliquem, de maneira satisfatória, a variabilidade observada nos preços, no mercado em que se estuda. Entretanto, não-normalidade, heteroscedasticidade e ...

  9. Cryo-EM structures of the TMEM16A calcium-activated chloride channel.

    Science.gov (United States)

    Dang, Shangyu; Feng, Shengjie; Tien, Jason; Peters, Christian J; Bulkley, David; Lolicato, Marco; Zhao, Jianhua; Zuberbühler, Kathrin; Ye, Wenlei; Qi, Lijun; Chen, Tingxu; Craik, Charles S; Jan, Yuh Nung; Minor, Daniel L; Cheng, Yifan; Jan, Lily Yeh

    2017-12-21

    Calcium-activated chloride channels (CaCCs) encoded by TMEM16A control neuronal signalling, smooth muscle contraction, airway and exocrine gland secretion, and rhythmic movements of the gastrointestinal system. To understand how CaCCs mediate and control anion permeation to fulfil these physiological functions, knowledge of the mammalian TMEM16A structure and identification of its pore-lining residues are essential. TMEM16A forms a dimer with two pores. Previous CaCC structural analyses have relied on homology modelling of a homologue (nhTMEM16) from the fungus Nectria haematococca that functions primarily as a lipid scramblase, as well as subnanometre-resolution electron cryo-microscopy. Here we present de novo atomic structures of the transmembrane domains of mouse TMEM16A in nanodiscs and in lauryl maltose neopentyl glycol as determined by single-particle electron cryo-microscopy. These structures reveal the ion permeation pore and represent different functional states. The structure in lauryl maltose neopentyl glycol has one Ca 2+ ion resolved within each monomer with a constricted pore; this is likely to correspond to a closed state, because a CaCC with a single Ca 2+ occupancy requires membrane depolarization in order to open (C.J.P. et al., manuscript submitted). The structure in nanodiscs has two Ca 2+ ions per monomer and its pore is in a closed conformation; this probably reflects channel rundown, which is the gradual loss of channel activity that follows prolonged CaCC activation in 1 mM Ca 2+ . Our mutagenesis and electrophysiological studies, prompted by analyses of the structures, identified ten residues distributed along the pore that interact with permeant anions and affect anion selectivity, as well as seven pore-lining residues that cluster near pore constrictions and regulate channel gating. Together, these results clarify the basis of CaCC anion conduction.

  10. Soil structure degradation in patches of alfalfa fields Degradação da estrutura do solo em "patches" em pastagens de alfafa

    Directory of Open Access Journals (Sweden)

    María Celeste Miretti

    2010-10-01

    propriedades do solo que podem afetar a produtividade da alfafa nos patches (PA e nas áreas normais (NA. Adicionalmente, os conteúdos de macro e micronutrientes foram determinados nas duas áreas. O experimento foi conduzido numa fazenda com solo Argiudol áquico. Dezoito pontos de amostragem foram estabelecidos, nove em PA e nove em NA. Em cada ponto foram coletadas amostras não perturbadas (5 × 5 cm para a determinação da densidade do solo (Ds, resistência do solo à penetração das raízes (RP, estresse efetivo (σ, curva de retenção de água e intervalo hídrico ótimo (IHO. Amostras perturbadas foram coletadas para avaliar o conteúdo de macro e micronutrientes, e a distribuição de partículas por tamanho. Não foram encontradas diferenças nas propriedades químicas entre PA e NA. Existe predomínio de agregados pequenos em PA, e a Ds, RP e s atingiram valores mais elevados em PA, enquanto o IHO foi mais estreito. Inadequada aeração em condições de excessiva umidade do solo e elevada resistência mecânica em condições de secamento poderão afetar a produtividade da alfafa. Os resultados indicam que a qualidade física do solo em PA é inferior que em NA.

  11. Modal Based Fatigue Monitoring of Steel Structures

    DEFF Research Database (Denmark)

    Graugaard-Jensen, J.; Brincker, Rune; Hjelm, H. P.

    2005-01-01

    In this paper it is shown how the accumulated fatigue in steel structures can be estimated with high accuracy by continuously measuring the accelerations in a few points of the structure. First step is to obtain a good estimate of the mode shapes by performing a natural input modal analysis. The so...... by applying the mode shapes of the calibrated Finite Element model and strains are obtained using the shape functions for the actual elements. The technique has been applied on a model frame structure in the laboratory and on a wind loaded lattice pylon structure. In both cases the estimated stresses has been...

  12. Design, construction and performance of an EMS-based HTS maglev vehicle

    International Nuclear Information System (INIS)

    Gu Chen; Liu Menglin; Xing Huawei; Zhou, Tong; Yin Wensheng; Zong Jun; Han Zhenghe

    2005-01-01

    A laboratory-scale EMS-based HTS maglev vehicle operating over a 1.5 m guideway has been successfully constructed. The fully integrated system consists of a vehicle chassis, four dependent magnetic circuits, four distance sensors, and control and power amplification circuits. As key component of the system, each magnetic circuit includes a U-shape iron core with one HTS coil forming each pole. Eight HTS coils made of Bi-2223 multi-filamentary tape were used to provide the magnetic motive force. Several questions relating to the unique characteristics of the HTS material in a controlled magnetic circuit are discussed. The most important consideration for such applications is that the anisotropic critical current of the Bi-2223/Ag tape depends strongly on the magnetic field. The commercially available FEA software ANSYS was used to simulate the field distribution along the magnetic circuit and HTS coil winding, and thereby identify how the magnetic circuit alters the field distribution in the coil winding and therefore also the critical current. A general optimization process is described for finding the best position in the U-shape iron core to hold the HTS coils. In this process the critical current of the HTS tape and the force-current characteristic of the magnetic circuit are considered synthetically. The results demonstrate the feasibility and stability of HTS material in a typical maglev system and other similar controllability applications

  13. Design, construction and performance of an EMS-based HTS maglev vehicle

    Energy Technology Data Exchange (ETDEWEB)

    Gu Chen [Applied Superconductivity Research Center, Department of Physics, Building LiZhai, Room 102, Tsinghua University, Beijing 100084 (China)]. E-mail: guchen@mail.tsinghua.edu.cn; Liu Menglin [Applied Superconductivity Research Center, Department of Physics, Building LiZhai, Room 102, Tsinghua University, Beijing 100084 (China); Xing Huawei [Department of Automation, Tsinghua University, Beijing 100084 (China); Zhou, Tong [Department of Automation, Tsinghua University, Beijing 100084 (China); Yin Wensheng [Department of Precision Instruments and Mechanology, Tsinghua University, Beijing 100084 (China); Zong Jun [Innova Superconductor Technology Co., Ltd., Beijing 100176 (China); Han Zhenghe [Applied Superconductivity Research Center, Department of Physics, Building LiZhai, Room 102, Tsinghua University, Beijing 100084 (China)

    2005-06-15

    A laboratory-scale EMS-based HTS maglev vehicle operating over a 1.5 m guideway has been successfully constructed. The fully integrated system consists of a vehicle chassis, four dependent magnetic circuits, four distance sensors, and control and power amplification circuits. As key component of the system, each magnetic circuit includes a U-shape iron core with one HTS coil forming each pole. Eight HTS coils made of Bi-2223 multi-filamentary tape were used to provide the magnetic motive force. Several questions relating to the unique characteristics of the HTS material in a controlled magnetic circuit are discussed. The most important consideration for such applications is that the anisotropic critical current of the Bi-2223/Ag tape depends strongly on the magnetic field. The commercially available FEA software ANSYS was used to simulate the field distribution along the magnetic circuit and HTS coil winding, and thereby identify how the magnetic circuit alters the field distribution in the coil winding and therefore also the critical current. A general optimization process is described for finding the best position in the U-shape iron core to hold the HTS coils. In this process the critical current of the HTS tape and the force-current characteristic of the magnetic circuit are considered synthetically. The results demonstrate the feasibility and stability of HTS material in a typical maglev system and other similar controllability applications.

  14. Agentes de saúde em comunidades urbanas Community-based health workers in urban areas

    Directory of Open Access Journals (Sweden)

    João Cláudio L. Fernandes

    1992-06-01

    Full Text Available A utilização de agentes comunitários nos programas de atenção primária à saúde é uma experiência amplamente difundida, principalmente nos países do Terceiro Mundo. É importante, entretanto, discriminar o perfil de atuação destes agentes em função da área onde atuam, principalmente no que diz respeito às diferenças entre o meio rural e o urbano. A simples substituição de profissionais de medicina, odontologia, psicologia etc, por agentes comunitários pode significar uma abordagem limitada do conceito de atenção primária, levando ao desenvolvimento de modelos assistenciais distintos, determinados em função da classe social a que se dirigem. Neste artigo, é apontada a necessidade de formação de recursos humanos de nível superior para a atenção primária à saúde, buscando-se também identificar o lugar dos agentes comunitários nesta área, sua especificidade técnica, bem como alguns obstáculos percebidos neste campo profissional.The employment of community-based health workers (CHWs in primary health care projects is a widespread experience, mainly in Third World countries. However, it is important to differentiate between the rural and urban profiles of these professionals. The replacement of medical/odontological/psychological professionals by CHWs alone may represent a limited approach to primary health care problems, leading to the development of different health care patterns, depending on the social class they are addressed. This paper points to need for the qualification of high-level health personnel also trying to identify the location of CHWs in this field, their technical specificity, as well as some difficulties observed in this practice.

  15. Reliability-Based Design of Coastal Structures

    DEFF Research Database (Denmark)

    Burcharth, H. F.

    1997-01-01

    The objective of this paper is to introduce the application of reliability theory for conceptual design and evaluation of coastal structures. It is without the scope to discuss the validity and quality of the various design formulae available for coastal structures. The contents of the paper is a....... Proceedings Conference of Port and Coastal Engineering in developing countries. Rio de Janeiro, Brazil, 1995....

  16. Molecular phylogeny of <em>Edraianthus em>(Grassy Bells; Campanulaceae) based on non-coding plastid DNA sequences

    DEFF Research Database (Denmark)

    Stefanovic, Sasa; Lakusic, Dmitar; Kuzmina, Maria

    2008-01-01

    The Balkan Peninsula is known as an ice-age refugium and an area with high rates of speciation and diversification. Only a few genera have their centers of distribution in the Balkans and the endemic genus Edraianthus is one of its most prominent groups. As such, Edraianthus is an excellent model...... divided into three sections: E. sect. Edraianthus, E. sect. Uniflori, and E. sect. Spathulati. We present here the first phylogenetic study of Edraianthus based on multiple plastid DNA sequences (trnL-F region and rbcL-atpB spacer) derived from a wide taxonomic sampling and geographic range. While...

  17. Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome.

    Science.gov (United States)

    Sun, Ji; MacKinnon, Roderick

    2017-06-01

    KCNQ1 is the pore-forming subunit of cardiac slow-delayed rectifier potassium (I Ks ) channels. Mutations in the kcnq1 gene are the leading cause of congenital long QT syndrome (LQTS). Here, we present the cryoelectron microscopy (cryo-EM) structure of a KCNQ1/calmodulin (CaM) complex. The conformation corresponds to an "uncoupled," PIP 2 -free state of KCNQ1, with activated voltage sensors and a closed pore. Unique structural features within the S4-S5 linker permit uncoupling of the voltage sensor from the pore in the absence of PIP 2 . CaM contacts the KCNQ1 voltage sensor through a specific interface involving a residue on CaM that is mutated in a form of inherited LQTS. Using an electrophysiological assay, we find that this mutation on CaM shifts the KCNQ1 voltage-activation curve. This study describes one physiological form of KCNQ1, depolarized voltage sensors with a closed pore in the absence of PIP 2 , and reveals a regulatory interaction between CaM and KCNQ1 that may explain CaM-mediated LQTS. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Structure based alignment and clustering of proteins (STRALCP)

    Science.gov (United States)

    Zemla, Adam T.; Zhou, Carol E.; Smith, Jason R.; Lam, Marisa W.

    2013-06-18

    Disclosed are computational methods of clustering a set of protein structures based on local and pair-wise global similarity values. Pair-wise local and global similarity values are generated based on pair-wise structural alignments for each protein in the set of protein structures. Initially, the protein structures are clustered based on pair-wise local similarity values. The protein structures are then clustered based on pair-wise global similarity values. For each given cluster both a representative structure and spans of conserved residues are identified. The representative protein structure is used to assign newly-solved protein structures to a group. The spans are used to characterize conservation and assign a "structural footprint" to the cluster.

  19. ESTUDO DOS EFEITOS FISIOLÓGICOS IN VITRO DE DIFERENTES BASES DE MEIO DE CULTURA E REGULADORES VEGETAIS EM EUCALIPTO

    Directory of Open Access Journals (Sweden)

    Débora de Araújo Mattos

    2017-05-01

    Full Text Available O cultivo in vitro de Eucalipto surgiu com a necessidade de clonar híbridos que possuam elevado valor econômico na indústria. Nesse contexto, objetivou-se avaliar a influência de diferentes meios de cultura (JADS e MS e citocininas (BAP, meta-Topolin e Kinetin em três concentrações (0,1; 0,2; 0,4 mg.L-1 no processo de multiplicação in vitro de dois híbridos de Eucalyptus grandis x Eucalyptus urophylla, nomeados como Clone 1 e Clone 2. Os resultados indicaram que os tratamentos em meio MS foram superiores ao meio JADS, e todos os tratamentos suplementados com Kinetin foram iguais ou semelhantes aos tratamentos sem regulador vegetal. Assim, o melhor tratamento para o Clone 1 foi em base de meio MS suplementado com 0,4 mg.L-1 de BAP, enquanto que para o Clone 2 foram os tratamentos em meio MS suplementados tanto com 0,2 mg.L-1 quanto 0,4 mg.L-1 de BAP.

  20. Proposed Doctrine Based Structure of the Armored Reconnaissance Squadron

    Science.gov (United States)

    2017-06-09

    squadron. A new structure was proposed based on the deduced required capabilities, utilizing organizational theory and current army practices. This...squadron, which now puts greater emphasis on this analysis to link structure to doctrinally based task. Organizational Theory Since earliest...expect to find capability based discourse; there is a lack of proposed structure based on capability, task or equipment . The Armour Bulletin serves

  1. Seasonal variation in Eurasian Wigeon <em>Anas penelopeem> sex and age ratios from hunter-based surveys

    DEFF Research Database (Denmark)

    Clausen, Kevin Kuhlmann; Dalby, Lars; Sunde, Peter

    2013-01-01

    dominated by adult males, and juvenile proportions were highest in November and significantly lower before and after this peak. Nationwide field assessments undertaken in January 2012 showed no significant differences from sex and age ratios in the wing survey data from that particular hunting season (2011...... schemes. This study found consistent seasonal variation in Eurasian Wigeon Anas penelope sex and age ratios among Danish hunter-based wing surveys, and describes how accounting for this variation might explain reported discrepancies between this and other monitoring methods. Early season flocks were....../2012), indicating that this survey is a good predictor of Wigeon demography. These results highlight the need to account for consistent temporal variation in such demographic time series when using the results to model population parameters....

  2. Prevention of enterotoxigenic <em>Escherichia coliem> infections in pigs by dairy-based nutrition

    DEFF Research Database (Denmark)

    Sugiharto, Sugiharto; Jensen, Bent Borg; Jensen, Karin Hjelholt

    2015-01-01

    bacterial disease outbreaks in piglets, the use of antibiotics at subtherapeutic concentrations has been banned in the European Union because of the increasing prevalence of resistance to antibiotics in pigs. The removal of in-feed antibiotics from piglet diets has negative economic consequences...... as it dramatically increases the rate of morbidity and mortality due to ETEC as well as the use of antibiotics for therapeutic purposes. Other than subtherapeutic antibiotics, zinc oxide (ZnO) has been reported to ameliorate and/or prevent the development of PWD in piglets, but its excretion may have negative...... impacts on the environment. Thus, other alternatives that can control ETEC infections in piglets postweaning will be of great advantage. A number of nutritional strategies have been proposed as alternative means of preventing ETEC infections, of which feeding dairy-based products to piglets could be one...

  3. Evolutionary Relationships Based on Cellular Structure.

    Science.gov (United States)

    Van Winkle, Lon J.

    1979-01-01

    This laboratory exercise integrates the topics of cell structure, classification of living organisms, and evolution. It is suitable for secondary or college biology courses and was used in an interdisciplinary science course for nonscience majors. (BB)

  4. Anemia em menores de seis anos: estudo de base populacional em Pelotas, RS Anemia in children under six: population-based study in Pelotas, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Maria Cecília Formoso Assunção

    2007-06-01

    Full Text Available OBJETIVO: Analisar a prevalência de anemia em crianças menores de seis anos, em uma amostra probabilística de área urbana. MÉTODOS: Foi realizado estudo com crianças de zero a cinco anos de idade, na cidade de Pelotas, RS, em 2004. Foram coletadas informações sobre características demográficas, socioeconômicas, antropométricas, de morbidade e sobre alimentação, por meio de questionário aplicado às mães ou responsáveis. As crianças foram pesadas e medidas. A concentração de hemoglobina foi medida com hemoglobinômetro portátil, HemoCue e anemia foi definida como valores de hemoglobina OBJECTIVE: To assess the prevalence of anemia among children under six years of age in a probabilistic sample from an urban area. METHODS: A study was conducted comprising children aged zero to five years in the city of Pelotas, Southern Brazil, in 2004. Data were collected on demographic, socioeconomic, and anthropometric characteristics, morbidity and nutrition using a questionnaire applied to the mothers and guardians. Children's weight and height measurements were obtained. Hemoglobin concentration was measured using the HemoCue portable hemoglobinometer and anemia was defined as hemoglobin <11 g/dL. The association between anemia and predictors was expressed as prevalence ratio. Multivariate analysis was carried out using Poisson regression following a conceptual model and taking into account the study design effect. RESULTS: There were identified 534 children and total losses and refusals were 27 (5.1%. The prevalence of anemia was 30.2% (95% CI 23.5%;37.0%. In the multivariate analysis, only age and family income remained significantly associated with anemia. CONCLUSIONS: Anemia was largely socially determined in the population studied. Interventions aiming at reducing anemia should be developed to lessen this condition in the short run targeting disadvantaged populations.

  5. Influence of stiffness in bolted connections in wooden plane structure of truss type Influência da rigidez de ligações parafusadas em estruturas planas de madeira do tipo treliça

    Directory of Open Access Journals (Sweden)

    André L. Christoforo

    2011-10-01

    Full Text Available Trusses are structural systems commonly used in projects, being employed mainly in roof structures, present in most rural buildings. The design of trusses, as well as other structural systems, requires the determination of displacements, strains and stresses. However, the project is developed from an ideal model of calculation, considering free rotation between the elements of a connection. This paper presents a computer program for the analysis of bidimensional wooden trusses with connections formed with two screws per node. The formulation is based on the flexibility method, taking into account the influence of the effect of semi-rigid connections formed by two screws. An example of a structure is presented and analyzed by the program developed here, highlighting the importance of behavior analysis on semi-rigid connections.Treliças são sistemas estruturais comumente utilizados em projetos, empregadas principalmente em estruturas de cobertura, presentes na maioria das construções rurais. O dimensionamento de treliças, assim como o de outros sistemas estruturais, requer a determinação dos deslocamentos, esforços, tensões e deformações atuantes em seus elementos constituintes. O cálculo é desenvolvido com base em um modelo ideal, considerando-se o giro livre entre os elementos componentes de uma ligação. Este trabalho objetiva apresentar um programa computacional destinado à análise de treliças planas de madeira com ligações formadas com dois parafusos por nó. A formulação é fundamentada no Método da Flexibilidade, levando-se em consideração a influência do efeito semirrígido das ligações formadas por dois parafusos. Um exemplo de estrutura auxiliar de cobertura é apresentado e analisado pelo programa desenvolvido, evidenciando-se a importância da análise do comportamento semirrígido sobre as ligações.

  6. Distributed Prognostics Based on Structural Model Decomposition

    Data.gov (United States)

    National Aeronautics and Space Administration — Within systems health management, prognostics focuses on predicting the remaining useful life of a system. In the model-based prognostics paradigm, physics-based...

  7. Natural Products from Antarctic Colonial Ascidians of the Genera <em>Aplidium> and <em>Synoicum>: Variability and Defensive Role

    Directory of Open Access Journals (Sweden)

    Conxita Avila

    2012-08-01

    Full Text Available Ascidians have developed multiple defensive strategies mostly related to physical, nutritional or chemical properties of the tunic. One of such is chemical defense based on secondary metabolites. We analyzed a series of colonial Antarctic ascidians from deep-water collections belonging to the genera <em>Aplidium> and <em>Synoicum> to evaluate the incidence of organic deterrents and their variability. The ether fractions from 15 samples including specimens of the species <em>A.> <em>falklandicum>, <em>A.> <em>fuegiense>, <em>A.> <em>meridianum>, <em>A.> <em>millari> and <em>S.> <em>adareanum> were subjected to feeding assays towards two relevant sympatric predators: the starfish <em>Odontaster> <em>validus>, and the amphipod <em>Cheirimedon> <em>femoratus>. All samples revealed repellency. Nonetheless, some colonies concentrated defensive chemicals in internal body-regions rather than in the tunic. Four ascidian-derived meroterpenoids, rossinones B and the three derivatives 2,3-epoxy-rossinone B, 3-epi-rossinone B, 5,6-epoxy-rossinone B, and the indole alkaloids meridianins A–G, along with other minoritary meridianin compounds were isolated from several samples. Some purified metabolites were tested in feeding assays exhibiting potent unpalatabilities, thus revealing their role in predation avoidance. Ascidian extracts and purified compound-fractions were further assessed in antibacterial tests against a marine Antarctic bacterium. Only the meridianins showed inhibition activity, demonstrating a multifunctional defensive role. According to their occurrence in nature and within our colonial specimens, the possible origin of both types of metabolites is discussed.

  8. Fast electromagnetic characterization of integrated circuit passive isolation structures based on interference blocking

    NARCIS (Netherlands)

    Grau Novellas, M.; Serra, R.; Rose, Matthias

    2017-01-01

    An early characterization of integrated circuit passive isolation structures is crucial to predict their performance and effectiveness in minimizing substrate coupling. In this paper, an electromagnetic (EM) modeling methodology is proposed, which can be applied to different types of isolation

  9. Reliability based Robustness of Timber Structures through NDT Data Updating

    DEFF Research Database (Denmark)

    Sousa, Hélder S.; Sørensen, John Dalsgaard; Kirkegaard, Poul Henning

    2011-01-01

    This work presents a framework for reliability-based assessment of timber structures / members using data gathered from non-destructive test results. These results are used for modeling an update of the mechanical characteristics of timber, using Bayesian methods. Results gathered from ultrasound...... of the structure, thus, being possible to evaluate reliability based in time dependent factors, as well to categorize that structure in terms of robustness. For exemplification of the underlined concepts, three different types of structures are studied....

  10. Incubator embedded cell culture imaging system (EmSight) based on Fourier ptychographic microscopy.

    Science.gov (United States)

    Kim, Jinho; Henley, Beverley M; Kim, Charlene H; Lester, Henry A; Yang, Changhuei

    2016-08-01

    Multi-day tracking of cells in culture systems can provide valuable information in bioscience experiments. We report the development of a cell culture imaging system, named EmSight, which incorporates multiple compact Fourier ptychographic microscopes with a standard multiwell imaging plate. The system is housed in an incubator and presently incorporates six microscopes. By using the same low magnification objective lenses as the objective and the tube lens, the EmSight is configured as a 1:1 imaging system that, providing large field-of-view (FOV) imaging onto a low-cost CMOS imaging sensor. The EmSight improves the image resolution by capturing a series of images of the sample at varying illumination angles; the instrument reconstructs a higher-resolution image by using the iterative Fourier ptychographic algorithm. In addition to providing high-resolution brightfield and phase imaging, the EmSight is also capable of fluorescence imaging at the native resolution of the objectives. We characterized the system using a phase Siemens star target, and show four-fold improved coherent resolution (synthetic NA of 0.42) and a depth of field of 0.2 mm. To conduct live, long-term dopaminergic neuron imaging, we cultured ventral midbrain from mice driving eGFP from the tyrosine hydroxylase promoter. The EmSight system tracks movements of dopaminergic neurons over a 21 day period.

  11. Structural differences between yeast and mammalian microtubules revealed by cryo-EM

    Energy Technology Data Exchange (ETDEWEB)

    Howes, Stuart C. [Univ. of California, Berkeley, CA (United States). Biophysics Graduate Group; Geyer, Elisabeth A. [Univ. of Texas Southwestern Medical Center, Dallas, TX (United States). Dept. of Biophysics; Univ. of Texas Southwestern Medical Center, Dallas, TX (United States). Dept. of Biochemistry; LaFrance, Benjamin [Univ. of California, Berkeley, CA (United States). Molecular and Cell Biology Graduate Program; Zhang, Rui [Univ. of California, Berkeley, CA (United States). Howard Hughes Medical Inst.; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Biophysics and Integrated Bioimaging Division; Kellogg, Elizabeth H. [Univ. of California, Berkeley, CA (United States). Howard Hughes Medical Inst.; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Biophysics and Integrated Bioimaging Division; Westermann, Stefan [Univ. of Duisburg-Essen, Essen (Germany). Dept. of Molecular Genetics, Center for Medical Biotechnology; Rice, Luke M. [Univ. of Texas Southwestern Medical Center, Dallas, TX (United States). Dept. of Biophysics; Univ. of Texas Southwestern Medical Center, Dallas, TX (United States). Dept. of Biochemistry; Nogales, Eva [Univ. of California, Berkeley, CA (United States). Howard Hughes Medical Inst.; Univ. of California, Berkeley, CA (United States). Dept. of Molecular Biology and California Inst. for Quantitative Biosciences; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Biophysics and Integrated Bioimaging Division

    2017-06-26

    Microtubules are polymers of αβ-tubulin heterodimers essential for all eukaryotes. Despite sequence conservation, there are significant structural differences between microtubules assembled in vitro from mammalian or budding yeast tubulin. Yeast MTs were not observed to undergo compaction at the interdimer interface as seen for mammalian microtubules upon GTP hydrolysis. Lack of compaction might reflect slower GTP hydrolysis or a different degree of allosteric coupling in the lattice. The microtubule plus end–tracking protein Bim1 binds yeast microtubules both between αβ-tubulin heterodimers, as seen for other organisms, and within tubulin dimers, but binds mammalian tubulin only at interdimer contacts. At the concentrations used in cryo-electron microscopy, Bim1 causes the compaction of yeast microtubules and induces their rapid disassembly. In conclusion, our studies demonstrate structural differences between yeast and mammalian microtubules that likely underlie their differing polymerization dynamics. These differences may reflect adaptations to the demands of different cell size or range of physiological growth temperatures.

  12. Cultivo de Oncidium baueri Lindley (Orchidaceae em substratos a base de coco Oncidium baueri Lindley (Orchidaceae cultivation in coconut-based substrates

    Directory of Open Access Journals (Sweden)

    Adriane Marinho de Assis

    2008-06-01

    Full Text Available Entre os substratos utilizados no cultivo de orquídeas, a fibra de coco vem se destacando como promissor substituto do xaxim, material utilizado por muitos produtores e colecionadores de orquídeas, porém ameaçado de extinção. Objetivou-se, neste trabalho, foi avaliar a eficiência de substratos à base de coco, no cultivo da orquídea Oncidium baueri. As mudas foram cultivadas em vasos de polipropileno, permanecendo em viveiro com 50% de luminosidade. Os tratamentos constituíram-se de xaxim desfibrado, coco desfibrado, coco em pó, coco desfibrado + coco em pó, coxim (coco em cubos, coxim + coco em pó e coxim + coco desfibrado. Após dezenove meses, foram avaliadas as variáveis: altura das plantas, diâmetro dos pseudobulbos, comprimento da maior raiz, massa seca das raízes, número de brotações e pH dos substratos. O delineamento experimental foi inteiramente casualizado, com sete tratamentos e dez repetições. Para todas as variáveis avaliadas, os substratos coco em pó e a mistura de coco desfibrado com coco em pó mostraram-se tão eficientes ao desenvolvimento das plantas quanto o xaxim desfibrado, podendo substituí-lo no cultivo de O. baueri.Among the several substrates used in orchid growing, coconut fiber is being considered the most promising substitute for xaxim (tree fern fiber, material highly used by orchid growers and collectors, which has become endangered. The objective of this study was to evaluate the efficiency of coconut-based substrates in the cultivation of the Brazilian orchid Oncidium baueri. Seedlings were grown in polypropylene vases kept in a nursery with 50% of lighting. Treatments included: defibered tree fern (control, de-fibered coconut, coconut powder, de-fibered coconut + coconut powder, coxim (diced coconut., coxim + coconut powder and coxim + de-fibered coconut. Plant height, pseudo bulbs diameter, number of buds, root dry matter weight, root length and pH substrate were evaluated 19 months

  13. Estratégia como prática: um estudo em empresas incubadas de base tecnológica

    Directory of Open Access Journals (Sweden)

    Jaiane Aparecida Pereira

    2015-01-01

    Full Text Available O presente artigo resulta de um estudo realizado em uma incubadora de base tecnológica localizada no Estado do Paraná objetivando analisar como os processos de formação de estratégias organizacionais, a partir de seu entendimento como prática social, se configuram em empresas incubadas e determinam os processos de inovação nesse contexto. Discute-se, a partir da filosofia do processo, como os processos de construção de estratégias organizacionais são articulados em relação à dinâmica social no qual os empreendedores estão imersos e formam as práticas em torno dos processos de inovação organizacional. Para tanto utilizou-se de uma abordagem qualitativa com entrevistas semiestruturadas como instrumento de coleta de dados. As análises das entrevistaqs foram construídas com base na técnica de análise de conteúdo. As categorias de análise foram construídas tendo por base a emergência e recorrência de alguns aspectos sobre o processo de construção das estratégias organizacionais, sendo eles: planejamento, tomada de decisão, flexibilidade da tomada de decisão, iniciativa individual e relacionamento com o mercado. A partir das análises dessas categorias pode-se perceber que o processo de estratégia nas empresas incubadas emerge segundo a concepção da estratégia como prática, sendo as estratégias formuladas de maneira menos formal e mais relacionadas ao tipo emergente.    

  14. Base connections for signal/sign structures.

    Science.gov (United States)

    2012-02-01

    The Atlantic hurricane season of 2004 brought with it a series of four major hurricanes that made landfall across : Florida within a six-week period. During this time, a number of cantilever sign structures along the state interstate system : failed....

  15. Structuring AHP-based maintenance policy selection

    NARCIS (Netherlands)

    Goossens, Adriaan; Basten, Robertus Johannes Ida; Hummel, J. Marjan; van der Wegen, Leonardus L.M.

    2015-01-01

    We aim to structure the maintenance policy selection process for ships, using the Analytic Hierarchy Process (AHP). Maintenance is an important contributor to reach the intended life-time of capital technical assets, and it is gaining increasing interest and relevance. A maintenance policy is a

  16. Risk Based Inspection Planning of Ageing Structures

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Ersdal, Gerhard

    2008-01-01

    . Different approaches for updating inspection plans for older installations are considered in order to achieve decreased inspection intervals as the structure are ageing. The most promising method consists in increasing the rate of defects / crack initiation at the end of the expected lifetime. Different...

  17. Photonic structures based on hybrid nanocomposites

    Science.gov (United States)

    Husaini, Saima

    In this thesis, photonic structures embedded with two types of nanomaterials, (i) quantum dots and (ii) metal nanoparticles are studied. Both of these exhibit optical and electronic properties different from their bulk counterpart due to their nanoscale physical structure. By integrating these nanomaterials into photonic structures, in which the electromagnetic field can be confined and controlled via modification of geometry and composition, we can enhance their linear and nonlinear optical properties to realize functional photonic structures. Before embedding quantum dots into photonic structures, we study the effect of various host matrices and fabrication techniques on the optical properties of the colloidal quantum dots. The two host matrices of interest are SU8 and PMMA. It is shown that the emission properties of the quantum dots are significantly altered in these host matrices (especially SU8) and this is attributed to a high rate of nonradiative quenching of the dots. Furthermore, the effects of fabrication techniques on the optical properties of quantum dots are also investigated. Finally a microdisk resonator embedded with quantum dots is fabricated using soft lithography and luminescence from the quantum dots in the disk is observed. We investigate the absorption and effective index properties of silver nanocomposite films. It is shown that by varying the fill factor of the metal nanoparticles and fabrication parameters such as heating time, we can manipulate the optical properties of the metal nanocomposite. Optimizing these parameters, a silver nanocomposite film with a 7% fill factor is prepared. A one-dimensional photonic crystal consisting of alternating layers of the silver nanocomposite and a polymer (Polymethyl methacrylate) is fabricated using spin coating and its linear and nonlinear optical properties are investigated. Using reflectivity measurements we demonstrate that the one-dimensional silver-nanocomposite-dielectric photonic crystal

  18. Bruxismo do sono: possibilidades terapêuticas baseadas em evidências Sleep bruxism: therapeutic possibilities based in evidences

    Directory of Open Access Journals (Sweden)

    Eduardo Machado

    2011-04-01

    Full Text Available INTRODUÇÃO: o bruxismo do sono (BS é uma desordem de movimentos estereotipados e periódicos, associados ao ranger e/ou apertar de dentes durante o sono, decorrentes da contração rítmica dos músculos mastigatórios. Essa condição não é uma doença, porém quando exacerbada pode ocasionar desequilíbrio e alteração das estruturas orofaciais. Dessa forma, surge a necessidade de se obter terapêuticas efetivas e seguras para o controle e o manejo do paciente bruxômano. As alternativas de tratamento variam desde terapêuticas orodentais e farmacológicas até técnicas comportamentais-cognitivas. OBJETIVOS: através de uma revisão sistemática da literatura, tendo como bases de pesquisa a Medline, Cochrane, Embase, Pubmed, Lilacs e BBO, no período compreendido entre 1990 e 2008, e com enfoque em estudos clínicos randomizados e quasi-randomizados, revisões sistemáticas e meta-análises, esse trabalho teve como objetivo analisar e discutir métodos de tratamento para o BS. RESULTADOS: pela análise da literatura verifica-se que existe uma grande quantidade de opções terapêuticas para o BS, porém muitas das terapias não têm suporte científico que as sustente. Assim, a escolha terapêutica deve ser pautada em evidências científicas e no bom senso clínico, objetivando uma melhora na qualidade de vida do paciente bruxômano.INTRODUCTION: Sleep bruxism (SB is defined as a stereotyped and periodic movement disorder, characterized by tooth grinding and/or clenching occurring during sleep, associated with rhythmic masticatory muscle activity. This condition isn't a disease, but when exacerbated may cause an unbalance and changing of orofacial structures. Thus, it is necessary to obtain effective and safe treatments for the control and management of the bruxist patient. The treatment alternatives ranges from oral devices to pharmacological and cognitive-behavioral techniques. OBJECTIVES: This study, through a systematic literature

  19. Potencialidades de Chlorella vulgaris cultivada em meio à base de concentrado de dessalinização

    OpenAIRE

    Matos, Ângelo Paggi

    2012-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias. Programa de Pós-Graduação em Ciência dos Alimentos. O objetivo deste trabalho foi avaliar as propriedades físicoquímicas da biomassa de Chlorella vulgaris em um meio à base de concentrado de dessalinização proveniente do processo de dessalinização de águas subterrâneas na comunidade de Uruçu, no município de São João do Cariri # Paraíba. O concentrado de dessalinização possui alta concentração de ...

  20. Descoberta de conhecimento em base de dados de eventos de desligamentos de empresas de distribuição

    OpenAIRE

    Tronchoni, Alex B.; Pretto, Carlos O.; Rosa, Mauro A. da; Lemos, Flávio A. Becon

    2010-01-01

    Este artigo explora a técnica de Descoberta de Conhecimento em Base de Dados (Knowledge Discovery in Databases - KDD) com o objetivo de qualificar a informação recolhida durante os trabalhos de recomposição de sistemas de distribuição por equipes de eletricistas. Esta qualificação possibilita a utilização de técnicas de Inteligência Artificial (IA) para apoiar decisões de investimentos em planejamento, operação e manutenção de sistemas de distribuição. Com o objetivo de ilustrar a importância...

  1. Moire-Fringe-Based Fiber Optic Tiltmeter for Structural Health Monitoring

    International Nuclear Information System (INIS)

    Kim, Dae Hyun

    2008-01-01

    This paper presents a novel fiber optic tiltmeter system for the health monitoring of large-size structures. The system is composed of a sensor head, a light control unit and a signal processing unit. The sensing mechanism of the sensor head is based on a novel integration of the moire fringe phenomenon with fiber optics to achieve a robust performance in addition to its immunity to EM interference, easy ratting, and low cost. In this paper, a prototype of the fiber optic tiltmeter system has been developed successfully. A low-cost light control unit has been developed to drive the system's optic and electronic components. From an experimental test, the fiber optic tiltmeter is proven to be a prospective sensor for the monitoring of the tilting angle of civil structure with a good linearity. Finally, the test also successfully demonstrates the performance and the potential of the novel fiber optic tiltmeter system to monitor the health of civil infrastructures.

  2. Utilização de subprodutos de origem animal em dietas formuladas com base em proteína bruta e proteína ideal para frangos de corte de 1 a 21 dias de idade

    OpenAIRE

    Cancherini,Luciana Cardoso; Junqueira,Otto Mack; Oliveira,Maria Cristina de; Andreotti,Marcelo de Oliveira; Barbosa,Maria José Baptista

    2005-01-01

    Foi conduzido um experimento para avaliar a utilização de subprodutos de origem animal em dietas para frangos de corte, formuladas com base na proteína bruta ou proteína ideal. O delineamento foi inteiramente casualizado em esquema fatorial 2x2+1, com duas fontes de proteína de origem animal (farinha de vísceras de aves e farinha de sangue bovino), dois conceitos de formulação (proteína bruta e proteína ideal) e uma dieta testemunha à base de milho e farelo de soja, com quatro repetições. As ...

  3. Analysis of Hybrid-Integrated High-Speed Electro-Absorption Modulated Lasers Based on EM/Circuit Co-simulation

    DEFF Research Database (Denmark)

    Johansen, Tom Keinicke; Krozer, Viktor; Kazmierski, C.

    2009-01-01

    An improved electromagnetic simulation (EM) based approach has been developed for optimization of the electrical to optical (E/O) transmission properties of integrated electro-absorption modulated lasers (EMLs) aiming at 100 Gbit/s Ethernet applications. Our approach allows for an accurate analysis...... of the EML performance in a hybrid microstrip assembly. The established EM-based approach provides a design methodology for the future hybrid integration of the EML with its driving electronics....

  4. Sintomatologia depressiva em adolescentes iniciais: estudo de base populacional Depressive symptomatology in early adolescents: population-based study

    Directory of Open Access Journals (Sweden)

    Luciano Dias de Mattos Souza

    2008-01-01

    Full Text Available OBJETIVO: Verificar a prevalência de sintomatologia depressiva em adolescentes entre 11 e 15 anos em Pelotas, RS, e identificar seus fatores associados. MÉTODOS: Estudo transversal de base populacional com amostra representativa de adolescentes da zona urbana da cidade de Pelotas, RS. Dos 448 setores censitários existentes no município, 79 foram aleatoriamente sorteados. Os jovens entre 11 e 15 anos localizados nestes setores foram convidados a responder o questionário auto-aplicado que continha perguntas sobre: idade, sexo, vida escolar, religião, atividades físicas, entretenimento, tabaco, consumo de álcool, uso de outras drogas, relacionamentos sexuais e conduta. Além disso, a sintomatologia depressiva dos adolescentes foi avaliada por meio da escala Children's Depression Inventory (CDI, também presente no instrumento de pesquisa. Para a análise dos dados foi utilizada a regressão logística ajustada ao modelo hierárquico. RESULTADOS: A prevalência de depressão foi de 2,1%. Após a regressão logística ajustada ao modelo hierárquico, estiveram significativamente associados à depressão: baixa condição socioeconômica, histórico de fracasso acadêmico, ausência de prática religiosa, abuso de álcool nos últimos 30 dias e indicativo de transtorno de conduta. CONCLUSÃO: É evidenciada a necessidade de programas preventivos e integrados de política na adolescência para depressão e comportamentos de risco à saúde.AIM: Verify the prevalence of depressive symptomatology in adolescents aged between 11 and 15 in Pelotas, RS, and identify its associated factors. METHODS: A cross-sectional base-populational study with a representative sample of adolescents of urban area of Pelotas, RS. Among the 448 census tracts in the urban area of Pelotas, 79 were randomly selected. Youths between 11 and 15 years answered a confidential self-report questionnaire on issues such as: age, gender, school life, religion, physical activities

  5. Structure-based bayesian sparse reconstruction

    KAUST Repository

    Quadeer, Ahmed Abdul

    2012-12-01

    Sparse signal reconstruction algorithms have attracted research attention due to their wide applications in various fields. In this paper, we present a simple Bayesian approach that utilizes the sparsity constraint and a priori statistical information (Gaussian or otherwise) to obtain near optimal estimates. In addition, we make use of the rich structure of the sensing matrix encountered in many signal processing applications to develop a fast sparse recovery algorithm. The computational complexity of the proposed algorithm is very low compared with the widely used convex relaxation methods as well as greedy matching pursuit techniques, especially at high sparsity. © 1991-2012 IEEE.

  6. Structural Bases of Postresuscitative Heart Failure

    Directory of Open Access Journals (Sweden)

    V. T. Dolgikh

    2005-01-01

    Full Text Available An experiment on 106 non-inbred male albino rats undergone 4-minute clinical death from acute blood loss has revealed that the first three days after resuscitation are marked by a concomitance of vascular disorders and cardiomyocytic dystrophic changes, the leading role being played by sludge, stasis, thrombosis, increased vascular permeability, perivascular edema, and hemorrhages. Cardiomyocytic destruction (various contractures, block-like myofibrillolysis, myocytoly-sis is a structural basis of postresuscitative heart failure. Three days later the heart displayed concomitant processes of recovery and damage. Three types of cardiac morphological changes have been identified in relation to the ratio of these processes.

  7. Benefits of Risk Based Inspection Planning for Offshore Structures

    DEFF Research Database (Denmark)

    Straub, D.M.; Goyet, J.; Sørensen, John Dalsgaard

    2006-01-01

    The economical benefits of applying risk-based inspection planning (RBI) for offshore structures subject to fatigue are evaluated based on experiences from past industrial projects. To this end, the factors influencing the cost of inspection, repair and failure of structures are discussed......, the financial benefit of RBI is assessed....

  8. Variabilidade em população base de pimenteiras ornamentais (Capsicum annuum L.

    Directory of Open Access Journals (Sweden)

    João José da Silva Neto

    2014-02-01

    Full Text Available O objetivo deste trabalho foi caracterizar progênies de uma população base de pimenteiras (Capsicum annuum L.. Foram utilizadas 54 plantas de uma geração F2 de pimenteiras ornamentais, para se avaliarem os seguintes caracteres morfoagronômicos: altura da planta (AP, diâmetro da copa (DDC, altura da primeira bifurcação (APB, diâmetro do caule (DCL, comprimento da folha (CFL, largura da folha (LFL, comprimento da corola (CDC, comprimento de antera (CANT, comprimento do estilete (CES e largura da pétala (LAP. O delineamento experimental foi inteiramente casualizado, com três repetições. Os dados foram submetidos à Análise de Variância, com posterior agrupamento das médias para o teste de Scott-Knott (p<0,01. Com exceção do CANT, verificaram-se diferenças significativas para os demais descritores, pelo Teste F. O DCL foi o descritor com maior herdabilidade (99,49%, seguido de DDC (96,14% e APB (94,05%. O caractere DCL apresentou maior variabilidade entre as plantas, formando 13 classes, seguido de DDC, com oito e APB, com seis classes. Quando se utilizaram as técnicas multivariadas, foi possível agrupar as 54 plantas em oito grupos, sendo o grupo 1 o que reuniu maior número de plantas (35. A característica que mais contribuiu para a divergência genética foi o diâmetro do caule (68,97%, seguida pelo diâmetro da copa (9,22%, altura da primeira bifurcação (6,76% e altura da planta (4,58%. Já as características de flor foram as que menos contribuíram para a variabilidade (10,47%. Houve variabilidade entre as plantas estudadas, sendo possível praticar seleção dentro dessa família, dando continuidade ao Programa de Melhoramento de Pimenteiras.

  9. Serial section scanning electron microscopy (S3EM) on silicon wafers for ultra-structural volume imaging of cells and tissues.

    Science.gov (United States)

    Horstmann, Heinz; Körber, Christoph; Sätzler, Kurt; Aydin, Daniel; Kuner, Thomas

    2012-01-01

    High resolution, three-dimensional (3D) representations of cellular ultrastructure are essential for structure function studies in all areas of cell biology. While limited subcellular volumes have been routinely examined using serial section transmission electron microscopy (ssTEM), complete ultrastructural reconstructions of large volumes, entire cells or even tissue are difficult to achieve using ssTEM. Here, we introduce a novel approach combining serial sectioning of tissue with scanning electron microscopy (SEM) using a conductive silicon wafer as a support. Ribbons containing hundreds of 35 nm thick sections can be generated and imaged on the wafer at a lateral pixel resolution of 3.7 nm by recording the backscattered electrons with the in-lens detector of the SEM. The resulting electron micrographs are qualitatively comparable to those obtained by conventional TEM. S(3)EM images of the same region of interest in consecutive sections can be used for 3D reconstructions of large structures. We demonstrate the potential of this approach by reconstructing a 31.7 µm(3) volume of a calyx of Held presynaptic terminal. The approach introduced here, Serial Section SEM (S(3)EM), for the first time provides the possibility to obtain 3D ultrastructure of large volumes with high resolution and to selectively and repetitively home in on structures of interest. S(3)EM accelerates process duration, is amenable to full automation and can be implemented with standard instrumentation.

  10. Serial section scanning electron microscopy (S3EM on silicon wafers for ultra-structural volume imaging of cells and tissues.

    Directory of Open Access Journals (Sweden)

    Heinz Horstmann

    Full Text Available High resolution, three-dimensional (3D representations of cellular ultrastructure are essential for structure function studies in all areas of cell biology. While limited subcellular volumes have been routinely examined using serial section transmission electron microscopy (ssTEM, complete ultrastructural reconstructions of large volumes, entire cells or even tissue are difficult to achieve using ssTEM. Here, we introduce a novel approach combining serial sectioning of tissue with scanning electron microscopy (SEM using a conductive silicon wafer as a support. Ribbons containing hundreds of 35 nm thick sections can be generated and imaged on the wafer at a lateral pixel resolution of 3.7 nm by recording the backscattered electrons with the in-lens detector of the SEM. The resulting electron micrographs are qualitatively comparable to those obtained by conventional TEM. S(3EM images of the same region of interest in consecutive sections can be used for 3D reconstructions of large structures. We demonstrate the potential of this approach by reconstructing a 31.7 µm(3 volume of a calyx of Held presynaptic terminal. The approach introduced here, Serial Section SEM (S(3EM, for the first time provides the possibility to obtain 3D ultrastructure of large volumes with high resolution and to selectively and repetitively home in on structures of interest. S(3EM accelerates process duration, is amenable to full automation and can be implemented with standard instrumentation.

  11. Protein 3D Structure and Electron Microscopy Map Retrieval Using 3D-SURFER2.0 and EM-SURFER.

    Science.gov (United States)

    Han, Xusi; Wei, Qing; Kihara, Daisuke

    2017-12-08

    With the rapid growth in the number of solved protein structures stored in the Protein Data Bank (PDB) and the Electron Microscopy Data Bank (EMDB), it is essential to develop tools to perform real-time structure similarity searches against the entire structure database. Since conventional structure alignment methods need to sample different orientations of proteins in the three-dimensional space, they are time consuming and unsuitable for rapid, real-time database searches. To this end, we have developed 3D-SURFER and EM-SURFER, which utilize 3D Zernike descriptors (3DZD) to conduct high-throughput protein structure comparison, visualization, and analysis. Taking an atomic structure or an electron microscopy map of a protein or a protein complex as input, the 3DZD of a query protein is computed and compared with the 3DZD of all other proteins in PDB or EMDB. In addition, local geometrical characteristics of a query protein can be analyzed using VisGrid and LIGSITE CSC in 3D-SURFER. This article describes how to use 3D-SURFER and EM-SURFER to carry out protein surface shape similarity searches, local geometric feature analysis, and interpretation of the search results. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc.

  12. Structural Acoustic Physics Based Modeling of Curved Composite Shells

    Science.gov (United States)

    2017-09-19

    NUWC-NPT Technical Report 12,236 19 September 2017 Structural Acoustic Physics -Based Modeling of Curved Composite Shells Rachel E. Hesse...SUBTITLE Structural Acoustic Physics -Based Modeling of Curved Composite Shells 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...study was to use physics -based modeling (PBM) to investigate wave propagations through curved shells that are subjected to acoustic excitation. An

  13. Generalização de modelos digitais de terreno com base em transformada wavelet

    Directory of Open Access Journals (Sweden)

    Clovis Gaboardi

    Full Text Available Os sistemas de laser scanner permitem a obtenção de modelos digitais de terreno de alta resolução e exatidão. Porém, quando se necessita trabalhar em aplicações com uma resolução menor que a originalmente gerada, a grande quantidade de dados acarreta a necessidade de generalização. Este trabalho tem por objetivo verificar o comportamento da transformada wavelet na generalização de modelos digitais do terreno sob a forma de grades regulares, obtidas a partir de dados do laser scanner. As transformadas wavelets foram implementadas em programas na linguagem Matlab. Foram utilizadas as wavelets de Haar, Daubechies e Symlet. A generalização por krigagem foi utilizada para a comparação dos resultados. Os resultados obtidos nos experimentos realizados permitem afirmar que a transformada wavelet pode ser utilizada como alternativa para a generalização de MDT em razão da facilidade de programação, baixo custo computacional, alta velocidade de processamento e exatidão compatível com a resolução obtida no MDT generalizado, além de ser um método natural de análise multirresolução.

  14. Land-locked Arctic charr (<em>Salvelinus alpinusem>) population structure and lake morphometry in Greenland - is there a connection?

    DEFF Research Database (Denmark)

    Riget, F.; Jeppesen, E.; Landkildehus, F.

    2000-01-01

    with lake volume. Our study indicates that the charr population structure became more complex with increasing lake size. More- over, the population structure seemed to be in¯uenced by lake-water transparency and the presence or absence of three-spined stickleback (Gasterosteus aculeatus)....

  15. A structural informatics approach to mine kinase knowledge bases.

    Science.gov (United States)

    Brooijmans, Natasja; Mobilio, Dominick; Walker, Gary; Nilakantan, Ramaswamy; Denny, Rajiah A; Feyfant, Eric; Diller, David; Bikker, Jack; Humblet, Christine

    2010-03-01

    In this paper, we describe a combination of structural informatics approaches developed to mine data extracted from existing structure knowledge bases (Protein Data Bank and the GVK database) with a focus on kinase ATP-binding site data. In contrast to existing systems that retrieve and analyze protein structures, our techniques are centered on a database of ligand-bound geometries in relation to residues lining the binding site and transparent access to ligand-based SAR data. We illustrate the systems in the context of the Abelson kinase and related inhibitor structures. 2009 Elsevier Ltd. All rights reserved.

  16. Combining ground-based and airborne EM through Artificial Neural Networks for modelling glacial till under saline groundwater conditions

    DEFF Research Database (Denmark)

    Gunnink, J.L.; Bosch, A.; Siemon, B.

    2012-01-01

    Airborne electromagnetic (AEM) methods supply data over large areas in a cost-effective way. We used ArtificialNeural Networks (ANN) to classify the geophysical signal into a meaningful geological parameter. By using examples of known relations between ground-based geophysical data (in this case...... electrical conductivity, EC, from electrical cone penetration tests) and geological parameters (presence of glacial till), we extracted learning rules that could be applied to map the presence of a glacial till using the EC profiles from the airborne EM data. The saline groundwater in the area was obscuring...

  17. Structural Health Monitoring Based on Combined Structural Global and Local Frequencies

    Directory of Open Access Journals (Sweden)

    Jilin Hou

    2014-01-01

    Full Text Available This paper presents a parameter estimation method for Structural Health Monitoring based on the combined measured structural global frequencies and structural local frequencies. First, the global test is experimented to obtain the low order modes which can reflect the global information of the structure. Secondly, the mass is added on the member of structure to increase the local dynamic characteristic and to make the member have local primary frequency, which belongs to structural local frequency and is sensitive to local parameters. Then the parameters of the structure can be optimized accurately using the combined structural global frequencies and structural local frequencies. The effectiveness and accuracy of the proposed method are verified by the experiment of a space truss.

  18. Equipment response spectra for base-isolated shear beam structures

    International Nuclear Information System (INIS)

    Ahmadi, G.; Su, L.

    1992-01-01

    Equipment response spectra in base-isolated structure under seismic ground excitations are studied. The equipment is treated as a single-degree-of-freedom system attached to a nonuniform elastic beam structural model. Several leading base isolation systems, including the laminated rubber bearing, the resilient-friction base isolator with and without a sliding upper plate, and the EDF system are considered. Deflection and acceleration response spectra for the equipment and the shear beam structure subject to a sinusoidal and the accelerogram of the N00W component of El Centro 1940 earthquake are evaluated. Primary-secondary interaction effects are included in the analysis. Several numerical parametric studies are carried out and the effectiveness of different base isolation systems in protecting the nonstructural components is studied. It is shown that use of properly designed base isolation systems provides considerable protection for secondary systems, as well as, the structure against severe seismic loadings. (orig.)

  19. Seismic Response Analysis and Design of Structure with Base Isolation

    International Nuclear Information System (INIS)

    Rosko, Peter

    2010-01-01

    The paper reports the study on seismic response and energy distribution of a multi-story civil structure. The nonlinear analysis used the 2003 Bam earthquake acceleration record as the excitation input to the structural model. The displacement response was analyzed in time domain and in frequency domain. The displacement and its derivatives result energy components. The energy distribution in each story provides useful information for the structural upgrade with help of added devices. The objective is the structural displacement response minimization. The application of the structural seismic response research is presented in base-isolation example.

  20. Performance-based shape optimization of continuum structures

    International Nuclear Information System (INIS)

    Liang Qingquan

    2010-01-01

    This paper presents a performance-based optimization (PBO) method for optimal shape design of continuum structures with stiffness constraints. Performance-based design concepts are incorporated in the shape optimization theory to achieve optimal designs. In the PBO method, the traditional shape optimization problem of minimizing the weight of a continuum structure with displacement or mean compliance constraints is transformed to the problem of maximizing the performance of the structure. The optimal shape of a continuum structure is obtained by gradually eliminating inefficient finite elements from the structure until its performance is maximized. Performance indices are employed to monitor the performance of optimized shapes in an optimization process. Performance-based optimality criteria are incorporated in the PBO method to identify the optimum from the optimization process. The PBO method is used to produce optimal shapes of plane stress continuum structures and plates in bending. Benchmark numerical results are provided to demonstrate the effectiveness of the PBO method for generating the maximum stiffness shape design of continuum structures. It is shown that the PBO method developed overcomes the limitations of traditional shape optimization methods in optimal design of continuum structures. Performance-based optimality criteria presented can be incorporated in any shape and topology optimization methods to obtain optimal designs of continuum structures.

  1. Strengthening of Concrete Structures with cement based bonded composites

    DEFF Research Database (Denmark)

    Täljsten, Björn; Blanksvärd, Thomas

    2008-01-01

    Polymers). The method is very efficient and has achieved world wide attention. However, there are some drawbacks with the use of epoxy, e.g. working environment, compatibility and permeability. Substituting the epoxy adherent with a cement based bonding agent will render a strengthening system...... with improved working environment and better compatibility to the base concrete structure. This study gives an overview of different cement based systems, all with very promising results for structural upgrading. Studied parameters are structural retrofit for bending, shear and confinement. It is concluded...

  2. Qualidade dos resumos estruturados apresentados em congresso médico Quality of the structured abstracts presented at a congress

    Directory of Open Access Journals (Sweden)

    Edilson F. dos Santos

    2007-08-01

    Full Text Available OBJETIVO: Avaliar e comparar a qualidade dos resumos apresentados em congresso médico (anais do XIV Congresso da Sociedade Brasileira de Infectologia, Novembro de 2005. A hipótese testada foi de que trabalhos de melhor qualidade são escolhidos para apresentação oral. MÉTODOS: Todos os 63 resumos apresentados oralmente e uma amostra aleatória simples (n=63 dos 664 expostos como pôster. A qualidade foi aferida por intermédio de questionário estruturado, constituído por 33 critérios, organizados em oito categorias: objetivo, delineamento, local, participantes, intervenção, medida das variáveis, resultados e conclusão. O questionário foi aplicado de maneira não cega por um dos pesquisadores. O escore final podia variar entre 0 (péssimo e 1 (excelente. RESULTADOS: Os resumos publicados nos anais do congresso obtiveram avaliação apenas regular na aferição da qualidade. Os escores médios de qualidade foram 0,60 e 0,62, respectivamente, para os resumos apresentados oralmente e como pôsteres (diferença não significativa; p=0,086. Os critérios que mais comprometeram a qualidade pertencem às categorias participantes, medida das variáveis, local e conclusão. CONCLUSÃO: A hipótese testada, de melhor qualidade dos resumos selecionados para apresentação oral, não foi confirmada. Recomenda-se aos organizadores de congressos a utilização de critérios objetivos de qualidade para selecionar a forma de exposição dos trabalhos nesse tipo de evento científico e mesmo melhorar a sua qualidade.OBJECTIVE: To assess and compare quality of abstracts presented at a medical congress (XIV Congresso da Sociedade Brasileira de Infectologia, November, 2005. The hypothesis is that material of better quality is chosen for oral presentation. METHODS: All the 63 abstracts selected for oral presentation were compared with a random sample (n=63 of the 664 abstracts registered as poster presentations. Quality was measured by a structured

  3. Dissimilarity-based classification of anatomical tree structures

    DEFF Research Database (Denmark)

    Sørensen, Lauge; Lo, Pechin Chien Pau; Dirksen, Asger

    2011-01-01

    A novel method for classification of abnormality in anatomical tree structures is presented. A tree is classified based on direct comparisons with other trees in a dissimilarity-based classification scheme. The pair-wise dissimilarity measure between two trees is based on a linear assignment betw...

  4. Dissimilarity-based classification of anatomical tree structures

    DEFF Research Database (Denmark)

    Sørensen, Lauge Emil Borch Laurs; Lo, Pechin Chien Pau; Dirksen, Asger

    2011-01-01

    A novel method for classification of abnormality in anatomical tree structures is presented. A tree is classified based on direct comparisons with other trees in a dissimilarity-based classification scheme. The pair-wise dissimilarity measure between two trees is based on a linear assignment...

  5. The Latent Structure of Secure Base Script Knowledge

    Science.gov (United States)

    Waters, Theodore E. A.; Fraley, R. Chris; Groh, Ashley M.; Steele, Ryan D.; Vaughn, Brian E.; Bost, Kelly K.; Veríssimo, Manuela; Coppola, Gabrielle; Roisman, Glenn I.

    2015-01-01

    There is increasing evidence that attachment representations abstracted from childhood experiences with primary caregivers are organized as a cognitive script describing secure base use and support (i.e., the "secure base script"). To date, however, the latent structure of secure base script knowledge has gone unexamined--this despite…

  6. Performance analysis of EM-based blind detection for ON-OFF keying modulation over atmospheric optical channels

    Science.gov (United States)

    Dabiri, Mohammad Taghi; Sadough, Seyed Mohammad Sajad

    2018-04-01

    In the free-space optical (FSO) links, atmospheric turbulence lead to scintillation in the received signal. Due to its ease of implementation, intensity modulation with direct detection (IM/DD) based on ON-OFF keying (OOK) is a popular signaling scheme in these systems. Over turbulence channel, to detect OOK symbols in a blind way, i.e., without sending pilot symbols, an expectation-maximization (EM)-based detection method was recently proposed in the literature related to free-space optical (FSO) communication. However, the performance of EM-based detection methods severely depends on the length of the observation interval (Ls). To choose the optimum values of Ls at target bit error rates (BER)s of FSO communications which are commonly lower than 10-9, Monte-Carlo simulations would be very cumbersome and require a very long processing time. To facilitate performance evaluation, in this letter we derive the analytic expressions for BER and outage probability. Numerical results validate the accuracy of our derived analytic expressions. Our results may serve to evaluate the optimum value for Ls without resorting to time-consuming Monte-Carlo simulations.

  7. A data base for aging of structural materials

    International Nuclear Information System (INIS)

    Oland, C.B.; Naus, D.J.; Jerath, S.

    1993-01-01

    The U.S. Nuclear Regulatory Commission (USNRC) initiated a Structural Aging (SAG) Program at the Oak Ridge National Laboratory (ORNL). The objective of the program is to provide assistance in identifying potential structural safety issues and to establish acceptance criteria for use in nuclear power plant evaluations for continued service. One of the main parts of the program focuses on the development of a Structural Materials Information Center where long-term and environment-dependent material properties are being collected and assembled into a data base. This data base is presented in two complementary formats. The Structural Materials Handbook is an expandable, hard-copy reference document that contains the complete data base for each material. The Structural Materials Electronic Data Base is accessible using an IBM-compatible personal computer. This paper presents an overview of the Structural Materials Information Center and briefly describes the features of the handbook and the electronic data base. In addition, a proposed method for using the data base to establish current property values for materials in existing concrete structures and to estimate the future performance of these materials is also presented. (author)

  8. A data base for aging of structural materials

    International Nuclear Information System (INIS)

    Oland, C.B.; Naus, D.J.; Jerath, S.

    1993-01-01

    USNRC initiated a Structural Aging (SAG) Program ORNL. The objective of the program is to provide assistance in identifying potential structural safety issues and to establish acceptance criteria for use in nuclear power plant evaluations for continued service. One main part focuses on the development of a Structural Materials Information Center where long-term and environment-dependent material properties are being collected and assembled into a data base. This data base is presented in two complementary formats. The Structural Materials Handbook is an expandable, hard-copy reference document that contains the complete data base for each material. The Structural Materials Electronic Data Base is accessible using an IBM-compatible personal computer. This paper presents an overview of the Structural Materials Information Center and briefly describes the features of the handbook and the electronic data base. In addition, a proposed method for using the data base to establish current property values for materials in existing concrete structures and to estimate the future performance of these materials is also presented

  9. Relações alométricas para estimativa da fitomassa aérea em pupunheira Peach palm biomass estimates based on allometric relationships

    Directory of Open Access Journals (Sweden)

    Fernando Vinicio A. Vega

    2004-03-01

    Full Text Available A estimativa da fitomassa aérea da pupunheira (Bactris gasipaes Kunth por meio de relações alométricas tem aplicação teórica e prática, sendo essencial em estudos de fisiologia de crescimento, bem como para identificar respostas e predizer a produção. No presente trabalho foram avaliadas diferentes equações buscando o melhor ajuste alométrico representativo da fitomassa da pupunheira cultivada para a produção de palmito. Foram utilizadas palmeiras inermes, da raça Putumayo, em diferentes estádios de desenvolvimento, cultivadas em Ubatuba (SP no espaçamento de 2 x 1 m. Selecionaram-se 117 plantas, com alturas entre 0,22 e 5,04 m e diâmetros entre 2,23 e 27,06 cm. Medidas diretas, relacionadas ao crescimento, foram realizadas antes do corte. Em seguida as plantas foram separadas em diferentes partes estruturais, sendo medidas, pesadas e secas, obtendo-se a massa da matéria seca. Os dados foram submetidos à análise de regressão e ajuste de equações, tendo como variáveis independentes os caracteres facilmente mensuráveis e não destrutivos. A fitomassa da pupunheira pode ser estimada de forma precisa a partir de equações simples, valendo-se de relações alométricas. A altura da haste principal, medida do solo até a inserção da folha +1, foi o caráter preditório indireto ideal para estimar a fitomassa de pupunheiras em cultivo comercial. Identificou-se também que, do estádio de implantação ao início de colheita de palmito, a contribuição dos perfilhos para a fitomassa aérea total é pequena e pode ser desprezada.Biomass estimates based on allometric relationships have theoretical and practical application. These data are useful tools in growth analysis experiments and yield prediction. Several equations were studied to define the best allometric fit to peach palm grown for heart-of-palm purpose. Spineless peach palms (Bactris gasipaes Kunth, from Putumayo landrace, were utilized. The experiment, in a 2 x 1

  10. Warning system based on theoretical-experimental study of dispersion of soluble pollutants in rivers Sistema de alerta com base em estudo teórico-experimental de dispersão de poluentes solúveis em rios

    Directory of Open Access Journals (Sweden)

    Celso B. de M. Ribeiro

    2011-10-01

    Full Text Available Information about capacity of transport and dispersion of soluble pollutants in natural streams are important in the management of water resources, especially in planning preventive measures to minimize the problems caused by accidental or intentional waste, in public health and economic activities that depend on the use of water. Considering this importance, this study aimed to develop a warning system for rivers, based on experimental techniques using tracers and analytical equations of one-dimensional transport of soluble pollutants conservative, to subsidizing the decision-making in the management of water resources. The system was development in JAVA programming language and MySQL database can predict the travel time of pollutants clouds from a point of eviction and graphically displays the temporal distribution of concentrations of passage clouds, in a particular location, downstream from the point of its launch.Informações sobre a capacidade de transporte e dispersão de poluentes solúveis em cursos de água naturais são importantes no gerenciamento dos recursos hídricos, principalmente no planejamento preventivo de medidas que visem a minimizar problemas à saúde pública e às atividades econômicas que dependem do uso da água, ocasionados por despejos acidentais ou intencionais. Considerando tal importância, este trabalho teve como objetivo desenvolver um sistema de alerta para rios, com base em resultados experimentais, utilizando técnicas de traçadores e equações analíticas de transporte unidimensional de poluentes solúveis conservativos, visando a subsidiar a tomada de decisão no gerenciamento dos recursos hídricos. O sistema desenvolvido em linguagem de programação JAVA e banco de dados MySQL permite prever o tempo de percurso da nuvem de poluentes a partir de um ponto de despejo de um poluente e apresenta, graficamente, a distribuição temporal de concentrações da passagem da nuvem, em um determinado local,

  11. Development of multifunctional fluoroelastomers based on nanocomposites; Desenvolvimento de elastomeros fluorados multifuncionais baseados em nanocompositos

    Energy Technology Data Exchange (ETDEWEB)

    Zen, Heloisa Augusto

    2015-07-01

    The fluoropolymers are known for their great mechanical properties, high thermal stability and resistance to aggressive chemical environment, and because of those properties they are widely used in industries, such as automobile, petroleum, chemistry, manufacturing, among others. To improve the thermal properties and gases barrier of the polymeric matrix, the incorporation of nanoparticle is used, this process permits the polymer to maintain their own characteristics and acquire new properties of nanoparticle. Because of those properties, the structural and morphological modification of fluoropolymers are very hard to be obtained through traditional techniques, in order to surmount this difficulty, the ionizing radiation is a well-known and effective method to modify fluoropolymers structures. In this thesis a nanocomposite polymeric based on fluoroelastomer (FKM) was developed and incorporated with four different configurations of nanoparticles: clay Cloisite 15A, POSS 1159, POSS 1160 and POSS 1163. After the nanocomposites films were obtained, a radiation induced grafting process was carried out, followed by sulfonation in order to obtain a ionic exchanged membrane. The effect of nanoparticle incorporation and the ionizing radiation onto films were characterized by X-ray diffraction, thermal and mechanical analysis, scanning electron microscopy and swelling; and the membranes were evaluated by degree of grafting, ionic exchange capacity and swelling. After the films were characterized, the crosslinking effect was observed to be predominant for the nanocomposites irradiated before the vulcanization, whereas the degradation was the predominant effect in the nanocomposites irradiated after vulcanization. (author)

  12. Digestibilidade aparente dos nutrientes de dietas simplificadas baseadas em forragens para coelhos em crescimento Apparent digestibility of nutrients of simplified diets based on forages for growing rabbits

    Directory of Open Access Journals (Sweden)

    W.M. Ferreira

    2007-04-01

    Full Text Available Avaliaram-se os efeitos de dietas simplificadas à base de forragens sobre a digestibilidade aparente dos nutrientes em coelhos Nova Zelândia branco. As dietas experimentais foram: referência (REF, feno de alfafa (FAL, feno das folhas de rami (FRA, feno das folhas de amoreira (FAM e feno do terço superior da rama da mandioca (FMA. A digestibilidade das dietas foi influenciada pelo tipo de alimento estudado; a FMA apresentou coeficientes de digestibilidade inferiores às demais dietas para todos os princípios nutritivos analisados. Para a dieta FAM, os coeficientes de digestibilidade aparente dos princípios nutritivos foram maiores (P0,05. Os valores estimados de energia digestível (kcal ED/kg MS e proteína digestível (%PD/MS foram, respectivamente, para o feno de alfafa: 2285,27 e 16,04; feno das folhas de rami: 1857,88 e 16,37; feno das folhas de amoreira: 2838,48 e 15,12 e feno do terço superior da mandioca: 2155,55 e 10,57.The effect of simplified diets based on forages on the apparent digestibility in white New Zealand rabbits was evaluated. The treatments were based on the following diets: reference (REF, hay of alfalfa (FAL, hay of rami leaves (FRA, hay of mulberry leaves (FAM and hay of upper to 1/3 aereal part of cassava (FMA. The type of food affected the digestibility of the diets. The FMA diet showed low coefficients of digestibility in comparison to the other diets for all the analyzed nutrients. For the FAM diet the coefficients of apparent digestibility of the nutrients had higher values (P0.05. The estimated values of digestible energy (kcal DE/kg DM and digestible protein (%DP/DM were, respectively, 2285.27 and 16.04 for alfalfa hay, 1857.88 and 16.37 for hay of rami leaves, 2838.48 and 15.12 for hay of mulberry leaves and 2155.55 and 10.57 for hay of upper to 1/3 aereal part of cassava.

  13. Jogo da Minoria: um modelo baseado em agentes aplicado ao mercado financeiro Minority Game: an agent-based model applied to financial market

    Directory of Open Access Journals (Sweden)

    Antonio Fernando Crepaldi

    2012-12-01

    Full Text Available Nos últimos anos houve uma contribuição significativa dos físicos para a construção de um tipo de modelo baseado em agentes que busca reproduzir, em simulação computacional, o comportamento do mercado financeiro. Esse modelo, chamado Jogo da Minoria consiste de um grupo de agentes que vão ao mercado comprar ou vender ativos. Eles tomam decisões com base em estratégias e, por meio delas, os agentes estabelecem um intrincado jogo de competição e coordenação pela distribuição da riqueza. O modelo tem demonstrado resultados bastante ricos e surpreendentes, tanto na dinâmica do sistema como na capacidade de reproduzir características estatísticas e comportamentais do mercado financeiro. Neste artigo, são apresentadas a estrutura e a dinâmica do Jogo da Minoria, bem como as contribuições recentes relacionadas ao Jogo da Minoria denominado de Grande Canônico, que é um modelo mais bem ajustado às características do mercado financeiro e reproduz as regularidades estatísticas do preço dos ativos chamadas fatos estilizados.Over the past ten years physicists have made a significant contribution to the building of an agent-based model to reproduce the behavior of financial markets using computer simulation. This model, called the Minority Game, consists of a group of agents that buy or sell assets. They make decisions based on strategies, and through them the agents establish an intricate game of competition and coordination resulting in the distribution of wealth. The model has shown outstanding surprising results concerning both the dynamics of the system and the ability to reproduce statistical and behavior characteristics of the financial market. In this study, the structure and dynamics of the Minority Game and the recent contributions related to the Grand Canonical Minority game, a model which is better adapted to the characteristics of the financial market and reproduce the statistical regularities of asset prices (called

  14. Graph-based linear scaling electronic structure theory

    Energy Technology Data Exchange (ETDEWEB)

    Niklasson, Anders M. N., E-mail: amn@lanl.gov; Negre, Christian F. A.; Cawkwell, Marc J.; Swart, Pieter J.; Germann, Timothy C.; Bock, Nicolas [Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Mniszewski, Susan M.; Mohd-Yusof, Jamal; Wall, Michael E.; Djidjev, Hristo [Computer, Computational, and Statistical Sciences Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Rubensson, Emanuel H. [Division of Scientific Computing, Department of Information Technology, Uppsala University, Box 337, SE-751 05 Uppsala (Sweden)

    2016-06-21

    We show how graph theory can be combined with quantum theory to calculate the electronic structure of large complex systems. The graph formalism is general and applicable to a broad range of electronic structure methods and materials, including challenging systems such as biomolecules. The methodology combines well-controlled accuracy, low computational cost, and natural low-communication parallelism. This combination addresses substantial shortcomings of linear scaling electronic structure theory, in particular with respect to quantum-based molecular dynamics simulations.

  15. Numerical and structural chromosome aberrations in cauliflower (Brassica oleracea var. botrytis) and Arabidopsis thaliana

    NARCIS (Netherlands)

    Ji, X.

    2014-01-01

    Numerical and structural chromosome aberrations in cauliflower (<em>Brassica oleracea em>var. <em>botrytis>) and <em>Arabidopsis thaliana.em>

    I studied numerical and structural chromosome aberrations in cauliflower (<em>Brassica oleracea em>var. <em>botrytis>) and

  16. Quantitative 3D Imaging by Cryo-EM (Shapes, membranes, and mapping of subcellular structures in whole bacteria)

    OpenAIRE

    Comolli, Luis R.; Downing, Kenneth H.; Fero, Michael J.; McAdams, Harley

    2006-01-01

    The shape of the bacteria cell wall during division and the deformation at the division plane are a function of the material properties of the cell wall, the growth rate, and the force due to the FtsZ ring. We have obtained 23 cryo-EM tomographic reconstructions through a time course following the cell division process in Caulobacter crescentus. We have also acquired over 300 images of the process by high resolution cryo-EM. The cell membranes have been segmented by an in-house developed util...

  17. Protein Function Prediction Based on Sequence and Structure Information

    KAUST Repository

    Smaili, Fatima Z.

    2016-01-01

    operate. In this master thesis project, we worked on inferring protein functions based on the primary protein sequence. In the approach we follow, 3D models are first constructed using I-TASSER. Functions are then deduced by structurally matching

  18. Electronic and chemical properties of graphene-based structures:

    DEFF Research Database (Denmark)

    Vanin, Marco

    In the present thesis several aspects of graphene-based structures have been investigated using density functional theory calculations to solve the electronic structure problem. A review of the implementation of a localized basis-set within the projector augmented wave method - the way of describ...... are attractive candidates although issues regarding the poisoning of the active site remain to be addressed....

  19. Economic structure and performance of forest-based industries

    International Nuclear Information System (INIS)

    O'Laughlin, J.

    1989-01-01

    This paper reports on the economic structure, conduct, and performance of industries dependent on the nation's forests that are topics of special importance for research. A major challenge to research involving industrial organization of forest-based industries is to link descriptions of structure, conduct, and industrial performance in ways that facilitate public and private policy making. Not to be overlooked is the need to continue efforts to monitor changes in structure and conduct dimensions at the national level and to conduct baseline studies of industry structure-conduct-performance at regional, state, and local levels. Specifically needed is research that will improve understanding of restructuring within the wood-based industry; definitions of the wood-based industry and segments thereof; linkages between structure and regional economic development; timberland as a managerial and economic variable; structural consequences of technological innovations; corporate strategies as related to performance; structural dimensions in an international setting; and structure and performance of nonwood-based forest industries. Economics research focused in such directions will go far toward improving the manner in which the nation's many forest industries organize and conduct their activities

  20. Probability based high temperature engineering creep and structural fire resistance

    CERN Document Server

    Razdolsky, Leo

    2017-01-01

    This volume on structural fire resistance is for aerospace, structural, and fire prevention engineers; architects, and educators. It bridges the gap between prescriptive- and performance-based methods and simplifies very complex and comprehensive computer analyses to the point that the structural fire resistance and high temperature creep deformations will have a simple, approximate analytical expression that can be used in structural analysis and design. The book emphasizes methods of the theory of engineering creep (stress-strain diagrams) and mathematical operations quite distinct from those of solid mechanics absent high-temperature creep deformations, in particular the classical theory of elasticity and structural engineering. Dr. Razdolsky’s previous books focused on methods of computing the ultimate structural design load to the different fire scenarios. The current work is devoted to the computing of the estimated ultimate resistance of the structure taking into account the effect of high temperatur...

  1. Microstructure and structural phase transitions in iron-based superconductors

    International Nuclear Information System (INIS)

    Wang Zhen; Cai Yao; Yang Huai-Xin; Tian Huan-Fang; Wang Zhi-Wei; Ma Chao; Chen Zhen; Li Jian-Qi

    2013-01-01

    Crystal structures and microstructural features, such as structural phase transitions, defect structures, and chemical and structural inhomogeneities, are known to have profound effects on the physical properties of superconducting materials. Recently, many studies on the structural properties of Fe-based high-T c superconductors have been published. This review article will mainly focus on the typical microstructural features in samples that have been well characterized by physical measurements. (i) Certain common structural features are discussed, in particular, the crystal structural features for different superconducting families, the local structural distortions in the Fe 2 Pn 2 (Pn = P As, Sb) or Fe 2 Ch 2 (Ch = S, Se, Te) blocks, and the structural transformations in the 122 system. (ii) In FeTe(Se) (11 family), the superconductivity, chemical and structural inhomogeneities are investigated and discussed in correlation with superconductivity. (iii) In the K 0.8 Fe 1.6+x Se 2 system, we focus on the typical compounds with emphasis on the Fe-vacancy order and phase separations. The microstructural features in other superconducting materials are also briefly discussed. (topical review - iron-based high temperature superconductors)

  2. Structure-based membrane dome mechanism for Piezo mechanosensitivity.

    Science.gov (United States)

    Guo, Yusong R; MacKinnon, Roderick

    2017-12-12

    Mechanosensitive ion channels convert external mechanical stimuli into electrochemical signals for critical processes including touch sensation, balance, and cardiovascular regulation. The best understood mechanosensitive channel, MscL, opens a wide pore, which accounts for mechanosensitive gating due to in-plane area expansion. Eukaryotic Piezo channels have a narrow pore and therefore must capture mechanical forces to control gating in another way. We present a cryo-EM structure of mouse Piezo1 in a closed conformation at 3.7Å-resolution. The channel is a triskelion with arms consisting of repeated arrays of 4-TM structural units surrounding a pore. Its shape deforms the membrane locally into a dome. We present a hypothesis in which the membrane deformation changes upon channel opening. Quantitatively, membrane tension will alter gating energetics in proportion to the change in projected area under the dome. This mechanism can account for highly sensitive mechanical gating in the setting of a narrow, cation-selective pore. © 2017, Guo et al.

  3. Cultivo de Ankistrodesmus gracilis (Chlorophyta em laboratório à base de esterco suíno

    Directory of Open Access Journals (Sweden)

    Tatiana Betioli Fioresi

    2008-01-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2008v21n1p7 O objetivo do presente trabalho foi testar a influência do meio à base de esterco suíno “in natura” e biodigerido, sobre o desenvolvimento, crescimento, comprimento total, peso seco e valor nutricional da microalga Ankistro desmus gracilis. O pico de crescimento para A. gracilis foi maior no meio biodigerido (6,2 x 107 células. mL-1 no volume de 2L. Alta porcentagem de lipídio foi observada no meio “in natura”, e, elevados teores de proteína no meio biodigerido em 2L. O biovolume, teor de cinzas e comprimento total foram diferentes (p 0,05. O requerimento de luz foi diferente entre os meios, com menor intensidade para o esterco biodigerido (13,5μE.cm-2.s-1, indicando menor custo benefício. O meio a base de esterco suíno, mostrou bons resultados para o crescimento de A. gracilis, com qualidade de água adequada para cultivo, podendo ser utilizado para cultura em larga escala.

  4. <em>In Vivoem> Histamine Optical Nanosensors

    Directory of Open Access Journals (Sweden)

    Heather A. Clark

    2012-08-01

    Full Text Available In this communication we discuss the development of ionophore based nanosensors for the detection and monitoring of histamine levels <em>in vivoem>. This approach is based on the use of an amine-reactive, broad spectrum ionophore which is capable of recognizing and binding to histamine. We pair this ionophore with our already established nanosensor platform, and demonstrate <em>in vitroem> and <em>in vivoem> monitoring of histamine levels. This approach enables capturing rapid kinetics of histamine after injection, which are more difficult to measure with standard approaches such as blood sampling, especially on small research models. The coupling together of <em>in vivoem> nanosensors with ionophores such as nonactin provide a way to generate nanosensors for novel targets without the difficult process of designing and synthesizing novel ionophores.

  5. Structures of OppA and PstS from <em>Yersinia pestisem> indicate variability of interactions with transmembrane domains

    DEFF Research Database (Denmark)

    Tanabe, Mikio; Mirza, Osman; Bertrand, Thomas

    2007-01-01

    -infective development. Here, the crystallization of five proteins (OppA, PstS, PiuA, YrbD and CysP) from Yersinia pestis, the causative agent of plague, are reported that diffracted to resolution limits ranging from 1.6 to 5 A. The first crystal structures of ABC system components from Y. pestis, OppA and Pst...

  6. Halogen effect on structure and 13C NMR chemical shift of 3,6-disubstituted-<em>N>-alkyl carbazoles

    DEFF Research Database (Denmark)

    Radula-Janik, Klaudia; Kupka, Teobald; Ejsmont, Krzysztof

    2013-01-01

    Structures of selected 3,6-dihalogeno-N-alkyl carbazole derivatives were calculated at the B3LYP/6-311++G(3df,2pd) level of theory and their 13C NMR isotropic nuclear shieldings were predicted using density functional theory (DFT). The model compounds contained 9H-, N-methyl and N-ethyl derivatives...

  7. <em>Chlorobium Tepidumem>: Insights into the Structure, Physiology, and Metabolism of a Green Sulfur Bacterium Derived from the Complete Genome Sequence

    DEFF Research Database (Denmark)

    Frigaard, Niels-Ulrik; Chew, Aline Gomez Maqueo; Li, Hui

    2003-01-01

    Green sulfur bacteria are obligate, anaerobic photolithoautotrophs that synthesize unique bacteriochlorophylls (BChls) and a unique light-harvesting antenna structure, the chlorosome. One organism, Chlorobium tepidum, has emerged as a model for this group of bacteria primarily due to its relative...

  8. Reconstruction of electrical impedance tomography (EIT) images based on the expectation maximum (EM) method.

    Science.gov (United States)

    Wang, Qi; Wang, Huaxiang; Cui, Ziqiang; Yang, Chengyi

    2012-11-01

    Electrical impedance tomography (EIT) calculates the internal conductivity distribution within a body using electrical contact measurements. The image reconstruction for EIT is an inverse problem, which is both non-linear and ill-posed. The traditional regularization method cannot avoid introducing negative values in the solution. The negativity of the solution produces artifacts in reconstructed images in presence of noise. A statistical method, namely, the expectation maximization (EM) method, is used to solve the inverse problem for EIT in this paper. The mathematical model of EIT is transformed to the non-negatively constrained likelihood minimization problem. The solution is obtained by the gradient projection-reduced Newton (GPRN) iteration method. This paper also discusses the strategies of choosing parameters. Simulation and experimental results indicate that the reconstructed images with higher quality can be obtained by the EM method, compared with the traditional Tikhonov and conjugate gradient (CG) methods, even with non-negative processing. Copyright © 2012 ISA. Published by Elsevier Ltd. All rights reserved.

  9. Neighboring Structure Visualization on a Grid-based Layout.

    Science.gov (United States)

    Marcou, G; Horvath, D; Varnek, A

    2017-10-01

    Here, we describe an algorithm to visualize chemical structures on a grid-based layout in such a way that similar structures are neighboring. It is based on structure reordering with the help of the Hilbert Schmidt Independence Criterion, representing an empirical estimate of the Hilbert-Schmidt norm of the cross-covariance operator. The method can be applied to any layout of bi- or three-dimensional shape. The approach is demonstrated on a set of dopamine D5 ligands visualized on squared, disk and spherical layouts. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Magnetophoresis of flexible DNA-based dumbbell structures

    Science.gov (United States)

    Babić, B.; Ghai, R.; Dimitrov, K.

    2008-02-01

    Controlled movement and manipulation of magnetic micro- and nanostructures using magnetic forces can give rise to important applications in biomedecine, diagnostics, and immunology. We report controlled magnetophoresis and stretching, in aqueous solution, of a DNA-based dumbbell structure containing magnetic and diamagnetic microspheres. The velocity and stretching of the dumbbell were experimentally measured and correlated with a theoretical model based on the forces acting on individual magnetic beads or the entire dumbbell structures. The results show that precise and predictable manipulation of dumbbell structures is achievable and can potentially be applied to immunomagnetic cell separators.

  11. Structure of 2,4-Diaminopyrimidine - Theobromine Alternate Base Pairs

    Science.gov (United States)

    Gengeliczki, Zsolt; Callahan, Michael P.; Kabelac, Martin; Rijs, Anouk M.; deVries, Mattanjah S.

    2011-01-01

    We report the structure of clusters of 2,4-diaminopyrimidine with 3,7-dimethylxanthine (theobromine) in the gas phase determined by IR-UV double resonance spectroscopy in both the near-IR and mid-IR regions in combination with ab initio computations. These clusters represent potential alternate nucleobase pairs, geometrically equivalent to guanine-cytosine. We have found the four lowest energy structures, which include the Watson-Crick base pairing motif. This Watson-Crick structure has not been observed by resonant two-photon ionization (R2PI) in the gas phase for the canonical DNA base pairs.

  12. Data base on avian mortality on man-made structures

    Energy Technology Data Exchange (ETDEWEB)

    Dailey, N. S.

    1978-01-01

    A computerized data base concerning avian mortality on man-made structures is available for searching at the Ecological Sciences Information Center of the Information Center Complex, Information Division, Oak Ridge National Laboratory. This data base, which contains entries from the available literature, provides information on avian mortality from either collision into or electrocution on man-made structures. Primary emphasis has been placed on avian collision with obstacles such as television and radio towers, airport ceilometers, transmission lines, and cooling towers. Other structures included in the studies are fences, glass walls and windows, lighthouses, telegraph and telephone wires, buildings, monuments, smokestacks, and water towers.

  13. SA-Search: a web tool for protein structure mining based on a Structural Alphabet

    OpenAIRE

    Guyon, Frédéric; Camproux, Anne-Claude; Hochez, Joëlle; Tufféry, Pierre

    2004-01-01

    SA-Search is a web tool that can be used to mine for protein structures and extract structural similarities. It is based on a hidden Markov model derived Structural Alphabet (SA) that allows the compression of three-dimensional (3D) protein conformations into a one-dimensional (1D) representation using a limited number of prototype conformations. Using such a representation, classical methods developed for amino acid sequences can be employed. Currently, SA-Search permits the performance of f...

  14. Betavoltaic Battery Conversion Efficiency Improvement Based on Interlayer Structures

    International Nuclear Information System (INIS)

    Li Da-Rang; Jiang Lan; Yin Jian-Hua; Lin Nai; Tan Yuan-Yuan

    2012-01-01

    Significant differences among the doping densities of PN junctions in semiconductors cause lattice mismatch and lattice defects that increase the recombination current of betavoltaic batteries. This extensively decreases the open circuit voltage and the short current, which results in low conversion efficiency. This study proposes P + PINN + -structure based betavoltaic batteries by adding an interlayer to typical PIN structures to improve conversion efficiency. Numerical simulations are conducted for the energy deposition of beta particles along the thickness direction in semiconductors. Based on this, 63 Ni-radiation GaAs batteries with PIN and P + PINN + structures are designed and fabricated to experimentally verify the proposed design. It turns out that the conversion efficiency of the betavoltaic battery with the proposed P + PINN + structure is about 1.45 times higher than that with the traditional PIN structure. (cross-disciplinary physics and related areas of science and technology)

  15. Reliability analysis of offshore structures using OMA based fatigue stresses

    DEFF Research Database (Denmark)

    Silva Nabuco, Bruna; Aissani, Amina; Glindtvad Tarpø, Marius

    2017-01-01

    focus is on the uncertainty observed on the different stresses used to predict the damage. This uncertainty can be reduced by Modal Based Fatigue Monitoring which is a technique based on continuously measuring of the accelerations in few points of the structure with the use of accelerometers known...... points of the structure, the stress history can be calculated in any arbitrary point of the structure. The accuracy of the estimated actual stress is analyzed by experimental tests on a scale model where the obtained stresses are compared to strain gauges measurements. After evaluating the fatigue...... stresses directly from the operational response of the structure, a reliability analysis is performed in order to estimate the reliability of using Modal Based Fatigue Monitoring for long term fatigue studies....

  16. Study on geology and geological structure based on literature studies

    International Nuclear Information System (INIS)

    Funaki, Hironori; Ishii, Eiichi; Yasue, Ken-ichi; Takahashi, Kazuharu

    2005-03-01

    Japan Nuclear Cycle Development Institute (JNC) is proceeding with underground research laboratory (URL) project for the sedimentary rock in Horonobe, Hokkaido. This project is an investigation project which is planned over 20 years. Surface-based investigations (Phase 1) have been conducted for the present. The purposes of the Phase 1 are to construct the geological environment model (geological-structural, hydrogeological, and hydrochemical models) and to confirm the applicability of investigation technologies for the geological environment. The geological-structural model comprises the base for the hydrogeological and hydrochemical models. We constructed the geological-structural model by mainly using data obtained from literature studies. Particulars regarding which data the model is based on and who has performed the interpretation are also saved for traceability. As a result, we explain the understanding of degree and the need of information on stratigraphy and discontinuous structure. (author)

  17. Generalized structured component analysis a component-based approach to structural equation modeling

    CERN Document Server

    Hwang, Heungsun

    2014-01-01

    Winner of the 2015 Sugiyama Meiko Award (Publication Award) of the Behaviormetric Society of Japan Developed by the authors, generalized structured component analysis is an alternative to two longstanding approaches to structural equation modeling: covariance structure analysis and partial least squares path modeling. Generalized structured component analysis allows researchers to evaluate the adequacy of a model as a whole, compare a model to alternative specifications, and conduct complex analyses in a straightforward manner. Generalized Structured Component Analysis: A Component-Based Approach to Structural Equation Modeling provides a detailed account of this novel statistical methodology and its various extensions. The authors present the theoretical underpinnings of generalized structured component analysis and demonstrate how it can be applied to various empirical examples. The book enables quantitative methodologists, applied researchers, and practitioners to grasp the basic concepts behind this new a...

  18. Genetic structure within and among regional populations of the Eurasian badger (<em>Meles melesem>) from Denmark and the Netherlands

    DEFF Research Database (Denmark)

    Zande, L. van de; Vliet, M. van de; Pertoldi, C.

    2007-01-01

    The Eurasian badger Meles meles has a wide distribution area ranging from Japan to Ireland. In western Europe badger habitats are severely disturbed by anthropogenic factors, leading to fragmentation into subpopulations and formation of a metapopulation substructuring of once continuous panmictic...... to this structuring of badger populations. In contrast, measures that improve migration and connection to other populations from neighboring countries may have prevented substructuring of the Dutch badger population....

  19. Cyclic Bis-1,3-dialkylpyridiniums from the Sponge <em>Haliclona> sp.

    Directory of Open Access Journals (Sweden)

    Jongheon Shin

    2012-09-01

    Full Text Available Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge <em>Haliclona> sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.

  20. Gradient-based optimization in nonlinear structural dynamics

    DEFF Research Database (Denmark)

    Dou, Suguang

    The intrinsic nonlinearity of mechanical structures can give rise to rich nonlinear dynamics. Recently, nonlinear dynamics of micro-mechanical structures have contributed to developing new Micro-Electro-Mechanical Systems (MEMS), for example, atomic force microscope, passive frequency divider......, frequency stabilization, and disk resonator gyroscope. For advanced design of these structures, it is of considerable value to extend current optimization in linear structural dynamics into nonlinear structural dynamics. In this thesis, we present a framework for modelling, analysis, characterization......, and optimization of nonlinear structural dynamics. In the modelling, nonlinear finite elements are used. In the analysis, nonlinear frequency response and nonlinear normal modes are calculated based on a harmonic balance method with higher-order harmonics. In the characterization, nonlinear modal coupling...

  1. General enumeration of RNA secondary structures based on new ...

    African Journals Online (AJOL)

    Crick base pairs between AU and GC. Based on the new representation, this paper also computes the number of various types of constrained secondary structures taking the minimum stack length 1 and minimum size m for each bonding loop as ...

  2. Towards Computerized Adaptive Assessment Based on Structured Tasks

    NARCIS (Netherlands)

    Tvarožek, Jozef; Kravcik, Milos; Bieliková, Mária

    2008-01-01

    Tvarožek, J., Kravčík, M., & Bieliková, M. (2008). Towards Computerized Adaptive Assessment Based on Structured Tasks. In W. Nejdl et al. (Eds.), Adaptive Hypermedia and Adaptive Web-Based Systems (pp. 224-234). Springer Berlin / Heidelberg.

  3. Design and manufacturing of bio-based sandwich structures

    CSIR Research Space (South Africa)

    John, Maya J

    2017-03-01

    Full Text Available The aim of this chapter is to discuss the design and manufacturing of bio-based sandwich structures. As the economic advantages of weight reduction have become mandatory for many advanced industries, bio-based sandwich panels have emerged...

  4. EM structure of a helicase-loader complex depicting a 6:2 binding sub-stoichiometry from Geobacillus kaustophilus HTA426

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Yen-Chen [Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan (China); Naveen, Vankadari [Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan (China); Molecular Cell Biology, Taiwan International Graduate Program, Institute of Molecular Biology, Academia Sinica, and Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan (China); Hsiao, Chwan-Deng, E-mail: hsiao@gate.sinica.edu.tw [Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan (China); Molecular Cell Biology, Taiwan International Graduate Program, Institute of Molecular Biology, Academia Sinica, and Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan (China)

    2016-04-22

    During DNA replication, bacterial helicase is recruited as a complex in association with loader proteins to unwind the parental duplex. Previous structural studies have reported saturated 6:6 helicase-loader complexes with different conformations. However, structural information on the sub-stoichiometric conformations of these previously-documented helicase-loader complexes remains elusive. Here, with the aid of single particle electron-microscopy (EM) image reconstruction, we present the Geobacillus kaustophilus HTA426 helicase-loader (DnaC-DnaI) complex with a 6:2 binding stoichiometry in the presence of ATPγS. In the 19 Å resolution EM map, the undistorted and unopened helicase ring holds a robust loader density above the C-terminal RecA-like domain. Meanwhile, the path of the central DNA binding channel appears to be obstructed by the reconstructed loader density, implying its potential role as a checkpoint conformation to prevent the loading of immature complex onto DNA. Our data also reveals that the bound nucleotides and the consequently induced conformational changes in the helicase hexamer are essential for active association with loader proteins. These observations provide fundamental insights into the formation of the helicase-loader complex in bacteria that regulates the DNA replication process. - Highlights: • Helicase-loader complex structure with 6:2 sub-stoichiometry is resolved by EM. • Helicase hexamer in 6:2 sub-stoichiometry is constricted and un-opened. • 6:2 binding ratio of helicase-loader complex could act as a DNA loading checkpoint. • Nucleotides stabilize helicase-loader complex at low protein concentrations.

  5. EM structure of a helicase-loader complex depicting a 6:2 binding sub-stoichiometry from Geobacillus kaustophilus HTA426

    International Nuclear Information System (INIS)

    Lin, Yen-Chen; Naveen, Vankadari; Hsiao, Chwan-Deng

    2016-01-01

    During DNA replication, bacterial helicase is recruited as a complex in association with loader proteins to unwind the parental duplex. Previous structural studies have reported saturated 6:6 helicase-loader complexes with different conformations. However, structural information on the sub-stoichiometric conformations of these previously-documented helicase-loader complexes remains elusive. Here, with the aid of single particle electron-microscopy (EM) image reconstruction, we present the Geobacillus kaustophilus HTA426 helicase-loader (DnaC-DnaI) complex with a 6:2 binding stoichiometry in the presence of ATPγS. In the 19 Å resolution EM map, the undistorted and unopened helicase ring holds a robust loader density above the C-terminal RecA-like domain. Meanwhile, the path of the central DNA binding channel appears to be obstructed by the reconstructed loader density, implying its potential role as a checkpoint conformation to prevent the loading of immature complex onto DNA. Our data also reveals that the bound nucleotides and the consequently induced conformational changes in the helicase hexamer are essential for active association with loader proteins. These observations provide fundamental insights into the formation of the helicase-loader complex in bacteria that regulates the DNA replication process. - Highlights: • Helicase-loader complex structure with 6:2 sub-stoichiometry is resolved by EM. • Helicase hexamer in 6:2 sub-stoichiometry is constricted and un-opened. • 6:2 binding ratio of helicase-loader complex could act as a DNA loading checkpoint. • Nucleotides stabilize helicase-loader complex at low protein concentrations.

  6. Monitoring of pipeline deformations using optical fiber sensors based on Bragg lattices; Monitoracao de deformacoes em dutos utilizando sensores a fibra optica com base em redes de Bragg

    Energy Technology Data Exchange (ETDEWEB)

    Moszkowica, Viktor Nigri [Pontificia Univ. Catolica do Rio de Janeiro, RJ (Brazil)]. E-mail: vnigri@bol.com.br

    2002-06-01

    In the petroleum sector there is a growing need for the use of pipelines as well as for their monitoring. A way to avoid leaks that can cause great damage to the environment is by the monitoring of deformations. In case failures can not be avoided through operational procedures, the monitoring of deformations can identify the initial moment and location of the leak, allowing for quick action on the part of the cleaning and depollution teams. Also important is the monitoring of slopes and soil movements. The same thing applies to production and transfer submarine pipelines subject to complex dynamic loadings that combine internal and external pressure, torsion, axial stress and, the most common of all, flexion loading. For this type of application, optical fiber sensors present a number of interesting features. Multiplexing, remote operation and long distance distribution of sensors are characteristics that attract their use in deformation monitoring systems. Presented herein are the research results of works that had the objective of developing deformation monitoring techniques in pipelines using optical fiber sensors based on Bragg grating. The technical feasibility of this technology is demonstrated through laboratorial tests. Also discussed herein are methods for field implementation of sensors, optical signal multiplexing techniques and potential advantages of applying this technology. (author)

  7. Value of information-based inspection planning for offshore structures

    DEFF Research Database (Denmark)

    Irman, Arifian Agusta; Thöns, Sebastian; Leira, Bernt J.

    2017-01-01

    with each inspection strategy. A simplified and generic risk-based inspection planning utilizing pre- posterior Bayesian decision analysis had been proposed by Faber et al. [1] and Straub [2]. This paper provides considerations on the theoretical background and a Value of Information analysis......-based inspection planning. The paper will start out with a review of the state-of-art RBI planning procedure based on Bayesian decision theory and its application in offshore structure integrity management. An example of the Value of Information approach is illustrated and it is pointed to further research......Asset integrity and management is an important part of the oil and gas industry especially for existing offshore structures. With declining oil price, the production rate is an important factor to be maintained that makes integrity of the structures one of the main concerns. Reliability based...

  8. Substrate structures for InP-based devices

    International Nuclear Information System (INIS)

    Wanlass, M.W.; Sheldon, P.

    1990-01-01

    A substrate structure for an InP-based semiconductor device having an InP based film is described. The substrate structure includes a substrate region having a lightweight bulk substrate and an upper GaAs layer. An interconnecting region is disposed between the substrate region and the InP-based device. The interconnecting region includes a compositionally graded intermediate layer substantially lattice-matched at the opposite end to the InP=based film. The interconnecting region further includes a dislocation mechanism disposed between the GaAs layer and the InP-based film in cooperation with the graded intermediate layer, the buffer mechanism blocking and inhibiting propagation of threading dislocations between the substrate region, and the InP-based device

  9. Prioridades estratégicas em serviços de pós-venda de uma empresa de manufatura de base tecnológica Strategic prioritization in after-sales services in a manufacturing technology center

    Directory of Open Access Journals (Sweden)

    Miguel Afonso Sellitto

    2011-01-01

    Full Text Available O objetivo deste artigo foi construir uma estrutura de temas estratégicos em serviços de pós-venda de uma empresa de manufatura de base tecnológica. O artigo faz uma revisão sobre operações e estratégia de pós-venda e apresenta a metodologia de pesquisa, o método de trabalho e os resultados de um caso-piloto em uma empresa de fabricação de equipamentos eletrônicos industriais. O método compreendeu sessões de grupos focados com especialistas que construíram uma estrutura de quatro temas estratégicos e vinte e três fatores de competição em pós-venda. A estrutura foi testada em questionário respondido por gestores da operação. Foram indagadas a importância e o desempenho da empresa nos fatores de competição da estrutura. Verificou-se que o fator reparos em bancada ou oficina tem mais desempenho que importância e está sobrevalorizado pela gestão. Também se verificou que os fatores testes acelerados, uso de confiabilidade em projeto e em garantia e uso de sistemas de informação para prospecção e para tratamento de clientes estão subvalorizados e poderiam receber mais recursos em uma eventual reformulação da estratégia de pós-venda. Os outros fatores mostraram-se equilibrados: os desempenhos avaliados são similares às importâncias atribuídas. Na continuidade, a pesquisa será estendida aos distribuidores da empresa que operam em campo a estratégia de pós-venda.This paper aimed at constructing a structure for strategic themes in after-sales services of a manufacturing technology center. After-sales service operations and strategy are reviewed and the research methodology, and the findings of a case study in an industrial electronic equipment manufacturer were presented. The method included team work that together with experts developed a structure composed of four strategic themes and twenty-three after sale competitive factors. The structure was tested by a questionnaire administered to operations managers

  10. Population structure of the malaria vector <em>Anopheles darlingiem> in a malaria-endemic region of Eastern Amazonian Brazil

    DEFF Research Database (Denmark)

    Conn, Jan E.; Vineis, Joseph H.; Bollback, Jonathan Paul

    2006-01-01

    of insecticides, but since the mid-1990s there has been a shift to patient treatment and focal insecticide fogging. Anopheles darlingi was believed to have been significantly reduced in a gold-mining community, Peixoto de Azevedo (in Mato Grosso State), in the early 1990s by insecticide use during a severe...... malaria epidemic. In contrast, although An. darlingi was eradicated from some districts of the city of Belem (the capital of Para State) in 1968 to reduce malaria, populations around the water protection area in the eastern district were treated only briefly. To investigate the population structure of An...

  11. CRBRP structural and thermal margin beyond the design base

    International Nuclear Information System (INIS)

    Strawbridge, L.E.

    1979-01-01

    Prudent margins beyond the design base have been included in the design of Clinch River Breeder Reactor Plant to further reduce the risk to the public from highly improbable occurrences. These margins include Structural Margin Beyond the Design Base to address the energetics aspects and Thermal Margin Beyond the Design Base to address the longer term thermal and radiological consequences. The assessments that led to the specification of these margins are described, along with the experimental support for those assessments. 8 refs

  12. Multifunctional Material Structures Based on Laser-Etched Carbon Nanotube Arrays

    Directory of Open Access Journals (Sweden)

    Aline Emplit

    2014-09-01

    Full Text Available High-power electronics in the transportation and aerospace sectors need size and weight reduction. Multifunctional and multistructured materials are currently being developed to couple electromagnetic (EM and thermal properties, i.e., shielding against electromagnetic impulsions, and thermal management across the thermal interface material (TIM. In this work, we investigate laser-machined patterned carbon nanotube (CNT micro-brushes as an alternative to metallic structures for driving simultaneously EM and heat propagation. The thermal and electromagnetic response of the CNT array is expected to be sensitive to the micro-structured pattern etched in the CNT brush.

  13. Structure-based classification and ontology in chemistry

    Directory of Open Access Journals (Sweden)

    Hastings Janna

    2012-04-01

    Full Text Available Abstract Background Recent years have seen an explosion in the availability of data in the chemistry domain. With this information explosion, however, retrieving relevant results from the available information, and organising those results, become even harder problems. Computational processing is essential to filter and organise the available resources so as to better facilitate the work of scientists. Ontologies encode expert domain knowledge in a hierarchically organised machine-processable format. One such ontology for the chemical domain is ChEBI. ChEBI provides a classification of chemicals based on their structural features and a role or activity-based classification. An example of a structure-based class is 'pentacyclic compound' (compounds containing five-ring structures, while an example of a role-based class is 'analgesic', since many different chemicals can act as analgesics without sharing structural features. Structure-based classification in chemistry exploits elegant regularities and symmetries in the underlying chemical domain. As yet, there has been neither a systematic analysis of the types of structural classification in use in chemistry nor a comparison to the capabilities of available technologies. Results We analyze the different categories of structural classes in chemistry, presenting a list of patterns for features found in class definitions. We compare these patterns of class definition to tools which allow for automation of hierarchy construction within cheminformatics and within logic-based ontology technology, going into detail in the latter case with respect to the expressive capabilities of the Web Ontology Language and recent extensions for modelling structured objects. Finally we discuss the relationships and interactions between cheminformatics approaches and logic-based approaches. Conclusion Systems that perform intelligent reasoning tasks on chemistry data require a diverse set of underlying computational

  14. Integrated Reliability-Based Optimal Design of Structures

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Thoft-Christensen, Palle

    1987-01-01

    In conventional optimal design of structural systems the weight or the initial cost of the structure is usually used as objective function. Further, the constraints require that the stresses and/or strains at some critical points have to be less than some given values. Finally, all variables......-based optimal design is discussed. Next, an optimal inspection and repair strategy for existing structural systems is presented. An optimization problem is formulated , where the objective is to minimize the expected total future cost of inspection and repair subject to the constraint that the reliability...... value. The reliability can be measured from an element and/or a systems point of view. A number of methods to solve reliability-based optimization problems has been suggested, see e.g. Frangopol [I]. Murotsu et al. (2], Thoft-Christensen & Sørensen (3] and Sørensen (4). For structures where...

  15. Ensemble-based prediction of RNA secondary structures.

    Science.gov (United States)

    Aghaeepour, Nima; Hoos, Holger H

    2013-04-24

    Accurate structure prediction methods play an important role for the understanding of RNA function. Energy-based, pseudoknot-free secondary structure prediction is one of the most widely used and versatile approaches, and improved methods for this task have received much attention over the past five years. Despite the impressive progress that as been achieved in this area, existing evaluations of the prediction accuracy achieved by various algorithms do not provide a comprehensive, statistically sound assessment. Furthermore, while there is increasing evidence that no prediction algorithm consistently outperforms all others, no work has been done to exploit the complementary strengths of multiple approaches. In this work, we present two contributions to the area of RNA secondary structure prediction. Firstly, we use state-of-the-art, resampling-based statistical methods together with a previously published and increasingly widely used dataset of high-quality RNA structures to conduct a comprehensive evaluation of existing RNA secondary structure prediction procedures. The results from this evaluation clarify the performance relationship between ten well-known existing energy-based pseudoknot-free RNA secondary structure prediction methods and clearly demonstrate the progress that has been achieved in recent years. Secondly, we introduce AveRNA, a generic and powerful method for combining a set of existing secondary structure prediction procedures into an ensemble-based method that achieves significantly higher prediction accuracies than obtained from any of its component procedures. Our new, ensemble-based method, AveRNA, improves the state of the art for energy-based, pseudoknot-free RNA secondary structure prediction by exploiting the complementary strengths of multiple existing prediction procedures, as demonstrated using a state-of-the-art statistical resampling approach. In addition, AveRNA allows an intuitive and effective control of the trade-off between

  16. Utilização de subprodutos de origem animal em dietas formuladas com base em proteína bruta e proteína ideal para frangos de corte de 22 a 42 dias de idade

    OpenAIRE

    Cancherini,Luciana Cardoso; Junqueira,Otto Mack; Oliveira,Maria Cristina de; Andreotti,Marcelo de Oliveira; Barbosa,Maria José Baptista

    2005-01-01

    Foi conduzido um experimento para avaliar a utilização de subprodutos de origem animal em dietas para frangos de corte de 22 a 42 dias de idade, formuladas com base nos conceitos de proteína bruta e proteína ideal. O delineamento foi inteiramente casualizado em esquema fatorial 2x2+1, ou seja, duas fontes de proteína de origem animal (farinha de vísceras de aves e farinha de sangue bovino), dois conceitos de formulação (proteína bruta e proteína ideal) e uma dieta controle à base de milho e f...

  17. Structured Light-Based 3D Reconstruction System for Plants

    OpenAIRE

    Nguyen, Thuy Tuong; Slaughter, David C.; Max, Nelson; Maloof, Julin N.; Sinha, Neelima

    2015-01-01

    Camera-based 3D reconstruction of physical objects is one of the most popular computer vision trends in recent years. Many systems have been built to model different real-world subjects, but there is lack of a completely robust system for plants. This paper presents a full 3D reconstruction system that incorporates both hardware structures (including the proposed structured light system to enhance textures on object surfaces) and software algorithms (including the proposed 3D point cloud regi...

  18. Oxidation resistance coating for niobium base structural composites

    International Nuclear Information System (INIS)

    Tabaru, T.; Shobu, K.; Kim, J.H.; Hirai, H.; Hanada, S.

    2003-01-01

    Oxidation behavior of Al-rich Mo(Si,Al) 2 base alloys, which is a candidate material for the oxidation resistance coating on Nb base structural composites, were investigated by thermogravimetry. The Mo(Si,Al) 2 base alloys containing Mo 5 (Si,Al) 3 up to about 10 vol% exhibits excellent oxidation resistance at temperatures ranging from 780 to 1580 K, particularly at 1580 K due to continuous Al 2 O 3 layer development. To evaluate the applicability of the Mo(Si,Al) 2 base coating, plasma spraying on Nb base composites were undertaken. However, interface reaction layer was found to form during the following heat treatment. Preparation of Mo(Si,Al) 2 /Al 2 O 3 /Nb layered structures via powder metallurgical process was attempted to preclude diffusion reaction between coating and substrate. (orig.)

  19. Smartphone based hemispherical photography for canopy structure measurement

    Science.gov (United States)

    Wan, Xuefen; Cui, Jian; Jiang, Xueqin; Zhang, Jingwen; Yang, Yi; Zheng, Tao

    2018-01-01

    The canopy is the most direct and active interface layer of the interaction between plant and environment, and has important influence on energy exchange, biodiversity, ecosystem matter and climate change. The measurement about canopy structure of plant is an important foundation to analyze the pattern, process and operation mechanism of forest ecosystem. Through the study of canopy structure of plant, solar radiation, ambient wind speed, air temperature and humidity, soil evaporation, soil temperature and other forest environmental climate characteristics can be evaluated. Because of its accuracy and effectiveness, canopy structure measurement based on hemispherical photography has been widely studied. However, the traditional method of canopy structure hemispherical photogrammetry based on SLR camera and fisheye lens. This method is expensive and difficult to be used in some low-cost occasions. In recent years, smartphone technology has been developing rapidly. The smartphone not only has excellent image acquisition ability, but also has the considerable computational processing ability. In addition, the gyroscope and positioning function on the smartphone will also help to measure the structure of the canopy. In this paper, we present a smartphone based hemispherical photography system. The system consists of smart phones, low-cost fisheye lenses and PMMA adapters. We designed an Android based App to obtain the canopy hemisphere images through low-cost fisheye lenses and provide horizontal collimation information. In addition, the App will add the acquisition location tag obtained by GPS and auxiliary positioning method in hemisphere image information after the canopy structure hemisphere image acquisition. The system was tested in the urban forest after it was completed. The test results show that the smartphone based hemispherical photography system can effectively collect the high-resolution canopy structure image of the plant.

  20. Hard and soft acids and bases: structure and process.

    Science.gov (United States)

    Reed, James L

    2012-07-05

    Under investigation is the structure and process that gives rise to hard-soft behavior in simple anionic atomic bases. That for simple atomic bases the chemical hardness is expected to be the only extrinsic component of acid-base strength, has been substantiated in the current study. A thermochemically based operational scale of chemical hardness was used to identify the structure within anionic atomic bases that is responsible for chemical hardness. The base's responding electrons have been identified as the structure, and the relaxation that occurs during charge transfer has been identified as the process giving rise to hard-soft behavior. This is in contrast the commonly accepted explanations that attribute hard-soft behavior to varying degrees of electrostatic and covalent contributions to the acid-base interaction. The ability of the atomic ion's responding electrons to cause hard-soft behavior has been assessed by examining the correlation of the estimated relaxation energies of the responding electrons with the operational chemical hardness. It has been demonstrated that the responding electrons are able to give rise to hard-soft behavior in simple anionic bases.

  1. Discrete Discriminant analysis based on tree-structured graphical models

    DEFF Research Database (Denmark)

    Perez de la Cruz, Gonzalo; Eslava, Guillermina

    The purpose of this paper is to illustrate the potential use of discriminant analysis based on tree{structured graphical models for discrete variables. This is done by comparing its empirical performance using estimated error rates for real and simulated data. The results show that discriminant a...... analysis based on tree{structured graphical models is a simple nonlinear method competitive with, and sometimes superior to, other well{known linear methods like those assuming mutual independence between variables and linear logistic regression.......The purpose of this paper is to illustrate the potential use of discriminant analysis based on tree{structured graphical models for discrete variables. This is done by comparing its empirical performance using estimated error rates for real and simulated data. The results show that discriminant...

  2. Symmetric metamaterials based on flower-shaped structure

    International Nuclear Information System (INIS)

    Tuong, P.V.; Park, J.W.; Rhee, J.Y.; Kim, K.W.; Cheong, H.; Jang, W.H.; Lee, Y.P.

    2013-01-01

    We proposed new models of metamaterials (MMs) based on a flower-shaped structure (FSS), whose “meta-atoms” consist of two flower-shaped metallic parts separated by a dielectric layer. Like the non-symmetric MMs based on cut-wire-pairs or electric ring resonators, the symmetrical FSS demonstrates the negative permeability at GHz frequencies. Employing the results, we designed a symmetric negative-refractive-index MM [a symmetric combined structure (SCS)], which is composed of FSSs and cross continuous wires. The MM properties of the FSS and the SCS are presented numerically and experimentally. - Highlights: • A new designed of sub-wavelength metamaterial, flower-shaped structure was proposed. • Flower-shaped meta-atom illustrated effective negative permeability. • Based on the meta-atom, negative refractive index was conventionally gained. • Negative refractive index was demonstrated with symmetric properties for electromagnetic wave. • Dimensional parameters were studied under normal electromagnetic wave

  3. A Tensor-Based Structural Damage Identification and Severity Assessment

    Science.gov (United States)

    Anaissi, Ali; Makki Alamdari, Mehrisadat; Rakotoarivelo, Thierry; Khoa, Nguyen Lu Dang

    2018-01-01

    Early damage detection is critical for a large set of global ageing infrastructure. Structural Health Monitoring systems provide a sensor-based quantitative and objective approach to continuously monitor these structures, as opposed to traditional engineering visual inspection. Analysing these sensed data is one of the major Structural Health Monitoring (SHM) challenges. This paper presents a novel algorithm to detect and assess damage in structures such as bridges. This method applies tensor analysis for data fusion and feature extraction, and further uses one-class support vector machine on this feature to detect anomalies, i.e., structural damage. To evaluate this approach, we collected acceleration data from a sensor-based SHM system, which we deployed on a real bridge and on a laboratory specimen. The results show that our tensor method outperforms a state-of-the-art approach using the wavelet energy spectrum of the measured data. In the specimen case, our approach succeeded in detecting 92.5% of induced damage cases, as opposed to 61.1% for the wavelet-based approach. While our method was applied to bridges, its algorithm and computation can be used on other structures or sensor-data analysis problems, which involve large series of correlated data from multiple sensors. PMID:29301314

  4. Structure based design of 11β-HSD1 inhibitors.

    Science.gov (United States)

    Singh, Suresh; Tice, Colin

    2010-11-01

    Controlling elevated tissue-specific levels of cortisol may provide a novel therapeutic approach for treating metabolic syndrome. This concept has spurred large scale medicinal chemistry efforts in the pharmaceutical industry for the design of 11β-HSD1 inhibitors. High resolution X-ray crystal structures of inhibitors in complex with the enzyme have facilitated the structure-based design of diverse classes of molecules. A summary of binding modes, trends in structure-activity relationships, and the pharmacodynamic data of inhibitors from each class is presented.

  5. Probability based load combinations for design of category I structures

    International Nuclear Information System (INIS)

    Reich, M.; Hwang, H.

    1985-01-01

    This paper discusses a reliability analysis method and a procedure for developing the load combination design criteria for category I structures. For safety evaluation of category I concrete structures under various static and dynamic loads, a probability-based reliability analysis method has been developed. This reliability analysis method is also used as a tool for determining the load factors for design of category I structures. In this paper, the load combinations for design of concrete containments, corresponding to a target limit state probability of 1.0 x 10 -6 in 4 years, are described. A comparison of containments designed using the ASME code and the proposed design criteria is also presented

  6. Optical-based smart structures for tamper-indicating applications

    International Nuclear Information System (INIS)

    Sliva, P.; Anheier, N.C.; Simmons, K.L.; Undem, H.A.

    1996-11-01

    This report is a compilation of several related projects performed from 1991 through 1996 concerning the design, construction, and application of optical-based smart structure to tamper-indicating and sensing secure containers. Due to several influences, the projects were carried through to varying degrees of completion. Cancellation of the overall project at the client level motivated the authors to gather all of the technology and ideas about smart structures developed during these several projects, whether completed or just conceptualized, into one document. Although each section individually discusses a specific project, the overall document is written chronologically with each successive section showing how increased smart structure complexity was integrated into the container

  7. Pre-Stressing Timber-Based Plate Tensegrity Structures

    DEFF Research Database (Denmark)

    Falk, Andreas; Kirkegaard, Poul Henning

    2012-01-01

    Tensile structures occur in numerous varieties utilising combinations of tension and compression. Introducing structural plates in the basic tensegrity unit and tensegric assemblies varies the range of feasible topologies and provides the structural system with an integrated surface. The present...... paper considers the concept of plate tensegrity based on CLT plates (cross-laminated timber). It combines the principles of tensegrity with the principles of plate shells and is characterised by a plate shell stabilised by struts and cables. The paper deals with material aspects and robustness of timber...

  8. Distance matrix-based approach to protein structure prediction.

    Science.gov (United States)

    Kloczkowski, Andrzej; Jernigan, Robert L; Wu, Zhijun; Song, Guang; Yang, Lei; Kolinski, Andrzej; Pokarowski, Piotr

    2009-03-01

    Much structural information is encoded in the internal distances; a distance matrix-based approach can be used to predict protein structure and dynamics, and for structural refinement. Our approach is based on the square distance matrix D = [r(ij)(2)] containing all square distances between residues in proteins. This distance matrix contains more information than the contact matrix C, that has elements of either 0 or 1 depending on whether the distance r (ij) is greater or less than a cutoff value r (cutoff). We have performed spectral decomposition of the distance matrices D = sigma lambda(k)V(k)V(kT), in terms of eigenvalues lambda kappa and the corresponding eigenvectors v kappa and found that it contains at most five nonzero terms. A dominant eigenvector is proportional to r (2)--the square distance of points from the center of mass, with the next three being the principal components of the system of points. By predicting r (2) from the sequence we can approximate a distance matrix of a protein with an expected RMSD value of about 7.3 A, and by combining it with the prediction of the first principal component we can improve this approximation to 4.0 A. We can also explain the role of hydrophobic interactions for the protein structure, because r is highly correlated with the hydrophobic profile of the sequence. Moreover, r is highly correlated with several sequence profiles which are useful in protein structure prediction, such as contact number, the residue-wise contact order (RWCO) or mean square fluctuations (i.e. crystallographic temperature factors). We have also shown that the next three components are related to spatial directionality of the secondary structure elements, and they may be also predicted from the sequence, improving overall structure prediction. We have also shown that the large number of available HIV-1 protease structures provides a remarkable sampling of conformations, which can be viewed as direct structural information about the

  9. 4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement.

    Science.gov (United States)

    Cong, Yao; Baker, Matthew L; Jakana, Joanita; Woolford, David; Miller, Erik J; Reissmann, Stefanie; Kumar, Ramya N; Redding-Johanson, Alyssa M; Batth, Tanveer S; Mukhopadhyay, Aindrila; Ludtke, Steven J; Frydman, Judith; Chiu, Wah

    2010-03-16

    The essential double-ring eukaryotic chaperonin TRiC/CCT (TCP1-ring complex or chaperonin containing TCP1) assists the folding of approximately 5-10% of the cellular proteome. Many TRiC substrates cannot be folded by other chaperonins from prokaryotes or archaea. These unique folding properties are likely linked to TRiC's unique heterooligomeric subunit organization, whereby each ring consists of eight different paralogous subunits in an arrangement that remains uncertain. Using single particle cryo-EM without imposing symmetry, we determined the mammalian TRiC structure at 4.7-A resolution. This revealed the existence of a 2-fold axis between its two rings resulting in two homotypic subunit interactions across the rings. A subsequent 2-fold symmetrized map yielded a 4.0-A resolution structure that evinces the densities of a large fraction of side chains, loops, and insertions. These features permitted unambiguous identification of all eight individual subunits, despite their sequence similarity. Independent biochemical near-neighbor analysis supports our cryo-EM derived TRiC subunit arrangement. We obtained a Calpha backbone model for each subunit from an initial homology model refined against the cryo-EM density. A subsequently optimized atomic model for a subunit showed approximately 95% of the main chain dihedral angles in the allowable regions of the Ramachandran plot. The determination of the TRiC subunit arrangement opens the way to understand its unique function and mechanism. In particular, an unevenly distributed positively charged wall lining the closed folding chamber of TRiC differs strikingly from that of prokaryotic and archaeal chaperonins. These interior surface chemical properties likely play an important role in TRiC's cellular substrate specificity.

  10. Image-based corrosion recognition for ship steel structures

    Science.gov (United States)

    Ma, Yucong; Yang, Yang; Yao, Yuan; Li, Shengyuan; Zhao, Xuefeng

    2018-03-01

    Ship structures are subjected to corrosion inevitably in service. Existed image-based methods are influenced by the noises in images because they recognize corrosion by extracting features. In this paper, a novel method of image-based corrosion recognition for ship steel structures is proposed. The method utilizes convolutional neural networks (CNN) and will not be affected by noises in images. A CNN used to recognize corrosion was designed through fine-turning an existing CNN architecture and trained by datasets built using lots of images. Combining the trained CNN classifier with a sliding window technique, the corrosion zone in an image can be recognized.

  11. Structure-Based Search for New Inhibitors of Cholinesterases

    Directory of Open Access Journals (Sweden)

    Barbara Malawska

    2013-03-01

    Full Text Available Cholinesterases are important biological targets responsible for regulation of cholinergic transmission, and their inhibitors are used for the treatment of Alzheimer’s disease. To design new cholinesterase inhibitors, of different structure-based design strategies was followed, including the modification of compounds from a previously developed library and a fragment-based design approach. This led to the selection of heterodimeric structures as potential inhibitors. Synthesis and biological evaluation of selected candidates confirmed that the designed compounds were acetylcholinesterase inhibitors with IC50 values in the mid-nanomolar to low micromolar range, and some of them were also butyrylcholinesterase inhibitors.

  12. Reliability-Based Structural Optimization of Wave Energy Converters

    DEFF Research Database (Denmark)

    Ambühl, Simon; Kramer, Morten; Sørensen, John Dalsgaard

    2014-01-01

    More and more wave energy converter (WEC) concepts are reaching prototype level. Once the prototype level is reached, the next step in order to further decrease the levelized cost of energy (LCOE) is optimizing the overall system with a focus on structural and maintenance (inspection) costs......, as well as on the harvested power from the waves. The target of a fully-developed WEC technology is not maximizing its power output, but minimizing the resulting LCOE. This paper presents a methodology to optimize the structural design of WECs based on a reliability-based optimization problem...

  13. Tamper indicating and sensing optical-based smart structures

    International Nuclear Information System (INIS)

    Sliva, P.; Anheier, N.C.; Gordon, N.R.; Simmons, K.L.; Stahl, K.A.; Undem, H.A.

    1995-05-01

    This paper has presented an overview of the type of optical-based structures that can be designed and constructed. These smart structures are capable of responding to their environment. The examples given represent a modest sampling of the complexity that can be achieved in both design and practice. Tamper-indicating containers and smart, sensing windows demonstrate just a few of the applications. We have shown that optical-based smart structures can be made multifunctional with the sensing built in. The next generation smart structure will combine the sensing functionality of these optical-based smart structures with other sensors such as piezoelectrics and electro-rheological fluids to not only be able to respond to the environment, but to adapt to it as well. An example of functionality in this regime would be a piezosensor that senses pressure changes (e.g., shock waves), which then causes an electro-rheological fluid to change viscosity. A fiber sensor located in or near the electro-rheological fluid senses the stiffness change and sends a signal through a feedback loop back to the piezosensor for additional adjustments to the electro-rheological fluid

  14. Interactive physically-based structural modeling of hydrocarbon systems

    International Nuclear Information System (INIS)

    Bosson, Mael; Grudinin, Sergei; Bouju, Xavier; Redon, Stephane

    2012-01-01

    Hydrocarbon systems have been intensively studied via numerical methods, including electronic structure computations, molecular dynamics and Monte Carlo simulations. Typically, these methods require an initial structural model (atomic positions and types, topology, etc.) that may be produced using scripts and/or modeling tools. For many systems, however, these building methods may be ineffective, as the user may have to specify the positions of numerous atoms while maintaining structural plausibility. In this paper, we present an interactive physically-based modeling tool to construct structural models of hydrocarbon systems. As the user edits the geometry of the system, atomic positions are also influenced by the Brenner potential, a well-known bond-order reactive potential. In order to be able to interactively edit systems containing numerous atoms, we introduce a new adaptive simulation algorithm, as well as a novel algorithm to incrementally update the forces and the total potential energy based on the list of updated relative atomic positions. The computational cost of the adaptive simulation algorithm depends on user-defined error thresholds, and our potential update algorithm depends linearly with the number of updated bonds. This allows us to enable efficient physically-based editing, since the computational cost is decoupled from the number of atoms in the system. We show that our approach may be used to effectively build realistic models of hydrocarbon structures that would be difficult or impossible to produce using other tools.

  15. Ab initio protein structure assembly using continuous structure fragments and optimized knowledge-based force field.

    Science.gov (United States)

    Xu, Dong; Zhang, Yang

    2012-07-01

    Ab initio protein folding is one of the major unsolved problems in computational biology owing to the difficulties in force field design and conformational search. We developed a novel program, QUARK, for template-free protein structure prediction. Query sequences are first broken into fragments of 1-20 residues where multiple fragment structures are retrieved at each position from unrelated experimental structures. Full-length structure models are then assembled from fragments using replica-exchange Monte Carlo simulations, which are guided by a composite knowledge-based force field. A number of novel energy terms and Monte Carlo movements are introduced and the particular contributions to enhancing the efficiency of both force field and search engine are analyzed in detail. QUARK prediction procedure is depicted and tested on the structure modeling of 145 nonhomologous proteins. Although no global templates are used and all fragments from experimental structures with template modeling score >0.5 are excluded, QUARK can successfully construct 3D models of correct folds in one-third cases of short proteins up to 100 residues. In the ninth community-wide Critical Assessment of protein Structure Prediction experiment, QUARK server outperformed the second and third best servers by 18 and 47% based on the cumulative Z-score of global distance test-total scores in the FM category. Although ab initio protein folding remains a significant challenge, these data demonstrate new progress toward the solution of the most important problem in the field. Copyright © 2012 Wiley Periodicals, Inc.

  16. Sinterização de cerâmicas à base de PZT em forno de microondas Microwave synthesis of PZT based ceramics

    Directory of Open Access Journals (Sweden)

    M. V. Gelfuso

    2007-09-01

    Full Text Available Cerâmicas de titanato e zirconato de chumbo dopadas com neodímio foram sinterizadas em um forno de microondas de uso doméstico modificado. Neste tipo de aquecimento, a energia eletromagnética é transferida diretamente para o material, sendo convertida em calor pelo material cerâmico, reduzindo o tempo e energia durante o processamento. Desta forma, foram produzidos corpos cerâmicos com tempo de sinterização que variou até 30 min, a 1100 e 1200 ºC. As fases foram investigadas por meio de difratometria de raios X. Corpos cerâmicos com densidade de 95% da teórica foram obtidos com tempo de sinterização de 10 min em 1100 ºC, com uma taxa de aquecimento de 400 ºC/min. Para as cerâmicas com densidade superior a 90% da teórica foram medidos os valores de constante dielétrica e fator de perda.Ferroelectric ceramics based on lead zirconate titanate doped with neodymium were sintered using a modified microwave oven. In this process the energy is transferred directly to the material through the interaction between molecules of the material with the electromagnetic field. The microwave sintering process has an advantage to reduce the time and save energy. This type of process involves energy conversion, opposing to heat transfer. Ceramic parts were produced by thermal treatments at 1100 ºC and 1200 ºC up to 30 min. The formed crystalline phases were investigated by X-ray diffraction. Ceramic parts with densities above 95% of the theoretical density were produced in 10 min by heating at 1100 ºC, with heating rate of 400 ºC/min. Values of dielectric constant and loss factor of ceramics with density above 90%T.D. were determined.

  17. Biomedical application of hierarchically built structures based on metal oxides

    Science.gov (United States)

    Korovin, M. S.; Fomenko, A. N.

    2017-12-01

    Nowadays, the use of hierarchically built structures in biology and medicine arouses much interest. The aim of this work is to review and summarize the available literature data about hierarchically organized structures in biomedical application. Nanoparticles can serve as an example of such structures. Medicine holds a special place among various application methods of similar systems. Special attention is paid to inorganic nanoparticles based on different metal oxides and hydroxides, such as iron, zinc, copper, and aluminum. Our investigations show that low-dimensional nanostructures based on aluminum oxides and hydroxides have an inhibitory effect on tumor cells and possess an antimicrobial activity. At the same time, it is obvious that the large-scale use of nanoparticles by humans needs to thoroughly study their properties. Special attention should be paid to the study of nanoparticle interaction with living biological objects. The numerous data show that there is no clear understanding of interaction mechanisms between nanoparticles and various cell types.

  18. Does the edge effect influence plant community structure in a tropical dry forest? O efeito de borda influencia a estrutura da comunidade vegetal em uma floresta tropical seca?

    Directory of Open Access Journals (Sweden)

    Diogo Gallo Oliveira

    2013-04-01

    Full Text Available Edge effects are considered a key factor in regulating the structure of plant communities in different ecosystems. However, regardless to few studies, edge influence does not seem to be decisive in semiarid regions such as the Brazilian tropical dry forest known as Caatinga but this issue remains inconclusive. The present study tests the null hypothesis that the plant community of shrubs and trees does not change in its structure due to edge effects. Twenty-four plots (20 x 20 m were set up in a fragment of Caatinga, in which 12 plots were in the forest edges and 12 plots were inside the fragment. Tree richness, abundance and species composition did not differ between edge and interior plots. The results of this study are in agreement with the pattern previously found for semiarid environments and contrasts with previous results obtained in different environments such as Rainforests, Savanna and Forest of Araucaria, which indicate abrupt differences between the border and interior of the plant communities in these ecosystems, and suggest that the community of woody plants of the Caatinga is not ecologically affected by the presence of edges.Efeitos de borda são considerados fator-chave na regulação da estrutura de comunidades vegetais em diferentes ecossistemas. Entretanto, apesar dos poucos estudos relacionados, o efeito de borda parece não ser determinante em regiões semiáridas, como a floresta tropical seca brasileira, conhecida como Caatinga. Este estudo testou a hipótese nula de que a comunidade vegetal arbustivo-arbórea não sofre alterações em sua estrutura, riqueza e composição devido ao efeito de borda. Foram instaladas 24 parcelas (20 x 20 m em um fragmento de Caatinga arbórea, sendo 12 parcelas na borda do fragmento e 12 parcelas no seu interior. A riqueza, abundância e composição das espécies não diferiram estatisticamente entre as parcelas de borda e interior. Os resultados deste estudo corroboram um possível padr

  19. A new entropy based method for computing software structural complexity

    CERN Document Server

    Roca, J L

    2002-01-01

    In this paper a new methodology for the evaluation of software structural complexity is described. It is based on the entropy evaluation of the random uniform response function associated with the so called software characteristic function SCF. The behavior of the SCF with the different software structures and their relationship with the number of inherent errors is investigated. It is also investigated how the entropy concept can be used to evaluate the complexity of a software structure considering the SCF as a canonical representation of the graph associated with the control flow diagram. The functions, parameters and algorithms that allow to carry out this evaluation are also introduced. After this analytic phase follows the experimental phase, verifying the consistency of the proposed metric and their boundary conditions. The conclusion is that the degree of software structural complexity can be measured as the entropy of the random uniform response function of the SCF. That entropy is in direct relation...

  20. Inelastic Structural Control Based on MBC and FAM

    Directory of Open Access Journals (Sweden)

    Li Gang

    2011-01-01

    Full Text Available A complex structure has the characters of many degrees of freedom and intricate shape, especially inelastic behavior under strong external loadings. It is hard to apply the structural control technology to it. In this paper, a new method that combines the Market-Based Control (MBC strategy and Force Analogy Method (FAM is presented to analyze the inelastic behavior of structure with magnetorheological dampers. The MBC is used to reduce the structural vibration response, and FAM is proposed to perform the inelastic analysis. A numerical example is used to compare the control effect of the new method and LQR algorithm, which show the accuracy and efficiency of the proposed computational method.

  1. Modern earthquake engineering offshore and land-based structures

    CERN Document Server

    Jia, Junbo

    2017-01-01

    This book addresses applications of earthquake engineering for both offshore and land-based structures. It is self-contained as a reference work and covers a wide range of topics, including topics related to engineering seismology, geotechnical earthquake engineering, structural engineering, as well as special contents dedicated to design philosophy, determination of ground motions, shock waves, tsunamis, earthquake damage, seismic response of offshore and arctic structures, spatial varied ground motions, simplified and advanced seismic analysis methods, sudden subsidence of offshore platforms, tank liquid impacts during earthquakes, seismic resistance of non-structural elements, and various types of mitigation measures, etc. The target readership includes professionals in offshore and civil engineering, officials and regulators, as well as researchers and students in this field.

  2. Search-based model identification of smart-structure damage

    Science.gov (United States)

    Glass, B. J.; Macalou, A.

    1991-01-01

    This paper describes the use of a combined model and parameter identification approach, based on modal analysis and artificial intelligence (AI) techniques, for identifying damage or flaws in a rotating truss structure incorporating embedded piezoceramic sensors. This smart structure example is representative of a class of structures commonly found in aerospace systems and next generation space structures. Artificial intelligence techniques of classification, heuristic search, and an object-oriented knowledge base are used in an AI-based model identification approach. A finite model space is classified into a search tree, over which a variant of best-first search is used to identify the model whose stored response most closely matches that of the input. Newly-encountered models can be incorporated into the model space. This adaptativeness demonstrates the potential for learning control. Following this output-error model identification, numerical parameter identification is used to further refine the identified model. Given the rotating truss example in this paper, noisy data corresponding to various damage configurations are input to both this approach and a conventional parameter identification method. The combination of the AI-based model identification with parameter identification is shown to lead to smaller parameter corrections than required by the use of parameter identification alone.

  3. Assessment of Peer-Based and Structural Strategies for Increasing ...

    African Journals Online (AJOL)

    Assessment of Peer-Based and Structural Strategies for Increasing Male Participation in an Antenatal Setting in Lilongwe, Malawi. SM Mphonda, NE Rosenberg, E Kamanga, I Mofolo, G Mwale, E Boa, M Mwale, F Martinson, I Hoffman, MC Hosseinipour ...

  4. Characterization and crystal structures of new Schiff base macrocyclic compounds

    Czech Academy of Sciences Publication Activity Database

    Khalaji, A.D.; Ghoran, S.H.; Pojarová, Michaela; Dušek, Michal

    2015-01-01

    Roč. 56, č. 7 (2015), s. 1410-1414 ISSN 0022-4766 R&D Projects: GA ČR(CZ) GA14-03276S Institutional support: RVO:68378271 Keywords : synthesis * macrocyclic Schiff base * single crystal structure analysis * spectroscopy Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.536, year: 2015

  5. Global stability-based design optimization of truss structures using ...

    Indian Academy of Sciences (India)

    Furthermore, a pure pareto-ranking based multi-objective optimization model is employed for the design optimization of the truss structure with multiple objectives. The computational performance of the optimization model is increased by implementing an island model into its evolutionary search mechanism. The proposed ...

  6. Structure and manual of radioisotope-production data base, ISOP

    International Nuclear Information System (INIS)

    Hata, Kentaro; Terunuma, Kusuo

    1994-02-01

    We planned on collecting the information of radioisotope production which was obtained from research works and tasks at the Department of Radioisotopes in JAERI, and constructed a proto-type data base ISOP after discussion of the kinds and properties of the information available for radioisotope production. In this report the structure and the manual of ISOP are described. (author)

  7. Structure and properties of compositions based on petroleum sulfonic acids

    Energy Technology Data Exchange (ETDEWEB)

    Tutorskii, I.A.; Sultanova, A.S.; Belkina, E.V.; Fomin, A.G. [Lomonosov Academy of Fine Chemical Technology, Moscow (Russian Federation)

    1995-03-01

    Colloidal characteristics of compositions based on petroleum sulfonic acids were studied. Neutralized heavy oil residue exhibits surface-active properties and contains an ultradisperse filler. Analysis of the compositions by size-exclusion-chromatography shows deep structural changes in the heavy acid residue upon neutralization with calcium carbonate.

  8. An improved AODV routing protocol based on tower structure

    Directory of Open Access Journals (Sweden)

    Li Yong Qiang

    2016-01-01

    Full Text Available The paper proposed a new routing protocol(IAODV based on tower structure in the Ad Hoc network for the problem which Location Routing Protocol need hardware and Complex algorithm. By the simulation, The complexity of the new routing protocol is reduced without reducing the performance of the network.

  9. Weighted voting-based consensus clustering for chemical structure databases

    Science.gov (United States)

    Saeed, Faisal; Ahmed, Ali; Shamsir, Mohd Shahir; Salim, Naomie

    2014-06-01

    The cluster-based compound selection is used in the lead identification process of drug discovery and design. Many clustering methods have been used for chemical databases, but there is no clustering method that can obtain the best results under all circumstances. However, little attention has been focused on the use of combination methods for chemical structure clustering, which is known as consensus clustering. Recently, consensus clustering has been used in many areas including bioinformatics, machine learning and information theory. This process can improve the robustness, stability, consistency and novelty of clustering. For chemical databases, different consensus clustering methods have been used including the co-association matrix-based, graph-based, hypergraph-based and voting-based methods. In this paper, a weighted cumulative voting-based aggregation algorithm (W-CVAA) was developed. The MDL Drug Data Report (MDDR) benchmark chemical dataset was used in the experiments and represented by the AlogP and ECPF_4 descriptors. The results from the clustering methods were evaluated by the ability of the clustering to separate biologically active molecules in each cluster from inactive ones using different criteria, and the effectiveness of the consensus clustering was compared to that of Ward's method, which is the current standard clustering method in chemoinformatics. This study indicated that weighted voting-based consensus clustering can overcome the limitations of the existing voting-based methods and improve the effectiveness of combining multiple clusterings of chemical structures.

  10. O Core Curriculum da Unesco como Base para Formação em Bioética

    Directory of Open Access Journals (Sweden)

    Fabiano Maluf

    Full Text Available RESUMO A revolução biotecnológica das últimas décadas teve como resultado o desenvolvimento de um poder quase sem limites sobre a vida humana. Tal contexto exige do profissional uma visão globalizada dos problemas éticos e sociais da era contemporânea, alicerçada em sólidas bases filosóficas e legais. Este contexto torna necessária a promoção de novas competências e habilidades relacionadas à vida profissional. Neste sentido, o ensino da Bioética desponta como uma possibilidade de inovação curricular alternativa ao tradicional modelo prescritivo e normativo. Este artigo relata a experiência da Cátedra Unesco de Bioética da Universidade de Brasília com a utilização do Core Curriculum proposto pela Unesco como instrumento didático-pedagógico adequado ao ensino da Bioética. Entre os dilemas pedagógicos enfrentados pela Bioética como disciplina encontram-se: a construção de seus conteúdos, sua estruturação, as concepções teóricas a serem seguidas e seus objetivos. A contextualização e o aperfeiçoamento da estratégia proposta pelo Core Curriculum podem significar importantes instrumentos facilitadores para docentes que buscam organizar práticas didático-pedagógicas inovadoras em Bioética com o intuito de proporcionar resultados efetivos na formação de seus estudantes.

  11. Quality assessment of protein model-structures based on structural and functional similarities.

    Science.gov (United States)

    Konopka, Bogumil M; Nebel, Jean-Christophe; Kotulska, Malgorzata

    2012-09-21

    Experimental determination of protein 3D structures is expensive, time consuming and sometimes impossible. A gap between number of protein structures deposited in the World Wide Protein Data Bank and the number of sequenced proteins constantly broadens. Computational modeling is deemed to be one of the ways to deal with the problem. Although protein 3D structure prediction is a difficult task, many tools are available. These tools can model it from a sequence or partial structural information, e.g. contact maps. Consequently, biologists have the ability to generate automatically a putative 3D structure model of any protein. However, the main issue becomes evaluation of the model quality, which is one of the most important challenges of structural biology. GOBA--Gene Ontology-Based Assessment is a novel Protein Model Quality Assessment Program. It estimates the compatibility between a model-structure and its expected function. GOBA is based on the assumption that a high quality model is expected to be structurally similar to proteins functionally similar to the prediction target. Whereas DALI is used to measure structure similarity, protein functional similarity is quantified using standardized and hierarchical description of proteins provided by Gene Ontology combined with Wang's algorithm for calculating semantic similarity. Two approaches are proposed to express the quality of protein model-structures. One is a single model quality assessment method, the other is its modification, which provides a relative measure of model quality. Exhaustive evaluation is performed on data sets of model-structures submitted to the CASP8 and CASP9 contests. The validation shows that the method is able to discriminate between good and bad model-structures. The best of tested GOBA scores achieved 0.74 and 0.8 as a mean Pearson correlation to the observed quality of models in our CASP8 and CASP9-based validation sets. GOBA also obtained the best result for two targets of CASP8, and

  12. Understanding of Android-Based Robotic and Game Structure

    Science.gov (United States)

    Phongtraychack, A.; Syryamkin, V.

    2018-05-01

    The development of an android with impressive lifelike appearance and behavior has been a long-standing goal in robotics and a new and exciting approach of smartphone-based robotics for research and education. Recent years have been progressive for many technologies, which allowed creating such androids. There are different examples including the autonomous Erica android system capable of conversational interaction and speech synthesis technologies. The behavior of Android-based robot could be running on the phone as the robot performed a task outdoors. In this paper, we present an overview and understanding of the platform of Android-based robotic and game structure for research and education.

  13. Sulla presenza di <em>Sorex antinoriiem>, <em>Neomys anomalusem> (Insectivora, Soricidae e <em>Talpa caecaem> (Insectivora, Talpidae in Umbria

    Directory of Open Access Journals (Sweden)

    A.M. Paci

    2003-10-01

    Full Text Available Lo scopo del contributo è di fornire un aggiornamento sulla presenza del Toporagno del Vallese <em>Sorex antinoriiem>, del Toporagno acquatico di Miller <em>Neomys anomalusem> e della Talpa cieca <em>Talpa caecaem> in Umbria, dove le specie risultano accertate ormai da qualche anno. A tal fine sono stati rivisitati i reperti collezionati e la bibliografia conosciuta. Toporagno del Vallese: elevato di recente a livello di specie da Brünner et al. (2002, altrimenti considerato sottospecie del Toporagno comune (<em>S. araneus antinoriiem>. È conservato uno di tre crani incompleti (mancano mandibole ed incisivi superiori al momento prudenzialmente riferiti a <em>Sorex> cfr. <em>antinorii>, provenienti dall?Appennino umbro-marchigiano settentrionale (dintorni di Scalocchio - PG, 590 m. s.l.m. e determinati sulla base della pigmentazione rossa degli ipoconi del M1 e M2; Toporagno acquatico di Miller: tre crani (Breda in Paci e Romano op. cit. e un esemplare intero (Paci, ined. sono stati trovati a pochi chilometri di distanza gli uni dall?altro tra i comuni di Assisi e Valfabbrica, in ambienti mediocollinari limitrofi al Parco Regionale del M.te Subasio (Perugia. In provincia di Terni la specie viene segnalata da Isotti (op. cit. per i dintorni di Orvieto. Talpa cieca: sono noti una femmina e un maschio raccolti nel comune di Pietralunga (PG, rispettivamente in una conifereta a <em>Pinus nigraem> (m. 630 s.l.m. e nelle vicinanze di un bosco misto collinare a prevalenza di <em>Quercus cerrisem> (m. 640 s.l.m.. Recentemente un terzo individuo è stato rinvenuto nel comune di Sigillo (PG, all?interno del Parco Regionale di M.te Cucco, sul margine di una faggeta a 1100 m s.l.m. In entrambi i casi l?areale della specie è risultato parapatrico con quello di <em>Talpa europaeaem>.

  14. A school-based oral health educational program: the experience of Maringa- PR, Brazil Programa educacional em saúde bucal baseado em escolas: a experiência de Maringá- PR, Brasil

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Conrado

    2004-03-01

    Full Text Available The main purpose of this study was to evaluate the preliminary results of a school-based oral health educational strategy adopted in public primary schools from the city of Maringa, State of Parana, Brazil. The study sample was composed by 556 children and adolescents aged 6 to 17 years old, 124 schoolteachers and a group of 55 mothers. The educational approach was implemented for 18 months and consisted of reinforcements of interventions addressed to students and schoolteachers at school level and few activities targeted at the mothers, performed by means of home visits. Baseline and follow-up interviews focused on oral health care were undertaken for the entire study population. As a stimulus for the students to achieve proper oral hygiene habits, the simplified oral hygiene index was assessed at three different moments. A statistically significant improvement in their oral hygiene index (pO principal propósito deste estudo foi avaliar os resultados preliminares de uma estratégia educacional baseada em escolas sobre saúde bucal adotada em escolas públicas de ensino fundamental da cidade de Maringá, estado do Paraná, Brasil. A amostra de estudo foi composta por 556 crianças e adolescentes entre 6 e 17 anos de idade, 124 professoras e um grupo de 55 mães. A abordagem educacional foi implementada por um período de 18 meses e consistiu de reforços das intervenções educativas dirigidas aos estudantes e professores a nível escolar e de poucas atividades tendo como alvo as mães, desenvolvidas através de visitas domiciliares. Entrevistas iniciais e de acompanhamento focando cuidados em saúde bucal foram realizadas com toda a população de estudo. Como um estímulo aos estudantes para assumirem hábitos apropriados de higiene bucal, o índice de higiene oral simplificado foi avaliado em três diferentes momentos. Uma melhora estatisticamente significante em seus índices de higiene oral (p< 0,001 foi registrada. Os resultados alcan

  15. Probabilistic structural damage identification based on vibration data

    International Nuclear Information System (INIS)

    Hao, H.; Xia, Y.

    2001-01-01

    Vibration-based methods are being rapidly developed and applied to detect structural damage in civil, mechanical and aerospace engineering communities in the last two decades. But uncertainties existing in the structural model and measured vibration data might lead to unreliable results. This paper will present some recent research results to tackle the above mentioned uncertainty problems. By assuming each of the FE model parameters and measured vibration data as a normally distributed random variable, a probabilistic damage detection procedure is developed based on perturbation method and validated by Monte Carlo simulation technique. With this technique, the damage probability of each structural element can be determined. The method developed has been verified by applying it to identify the damages of laboratory tested structures. It was proven that, as compared to the deterministic damage identification method, the present method can not only reduce the possibility of false identification, but also give the identification results in terms of probability. which is deemed more realistic and practical in detecting possible damages in a structure. It has also been found that the modal data included in damage identification analysis have a great influence on the identification results. With a sensitivity study, an optimal measurement set for damage detection is determined. This set includes the optimal measurement locations and the most appropriate modes that should be used in the damage identification analysis. Numerical results indicated that if the optimal set determined in a pre-analysis is used in the damage detection better results will be achieved. (author)

  16. Single-Walled Carbon-Nanotubes-Based Organic Memory Structures

    Directory of Open Access Journals (Sweden)

    Sundes Fakher

    2016-09-01

    Full Text Available The electrical behaviour of organic memory structures, based on single-walled carbon-nanotubes (SWCNTs, metal–insulator–semiconductor (MIS and thin film transistor (TFT structures, using poly(methyl methacrylate (PMMA as the gate dielectric, are reported. The drain and source electrodes were fabricated by evaporating 50 nm gold, and the gate electrode was made from 50 nm-evaporated aluminium on a clean glass substrate. Thin films of SWCNTs, embedded within the insulating layer, were used as the floating gate. SWCNTs-based memory devices exhibited clear hysteresis in their electrical characteristics (capacitance–voltage (C–V for MIS structures, as well as output and transfer characteristics for transistors. Both structures were shown to produce reliable and large memory windows by virtue of high capacity and reduced charge leakage. The hysteresis in the output and transfer characteristics, the shifts in the threshold voltage of the transfer characteristics, and the flat-band voltage shift in the MIS structures were attributed to the charging and discharging of the SWCNTs floating gate. Under an appropriate gate bias (1 s pulses, the floating gate is charged and discharged, resulting in significant threshold voltage shifts. Pulses as low as 1 V resulted in clear write and erase states.

  17. Blind Test of Physics-Based Prediction of Protein Structures

    Science.gov (United States)

    Shell, M. Scott; Ozkan, S. Banu; Voelz, Vincent; Wu, Guohong Albert; Dill, Ken A.

    2009-01-01

    We report here a multiprotein blind test of a computer method to predict native protein structures based solely on an all-atom physics-based force field. We use the AMBER 96 potential function with an implicit (GB/SA) model of solvation, combined with replica-exchange molecular-dynamics simulations. Coarse conformational sampling is performed using the zipping and assembly method (ZAM), an approach that is designed to mimic the putative physical routes of protein folding. ZAM was applied to the folding of six proteins, from 76 to 112 monomers in length, in CASP7, a community-wide blind test of protein structure prediction. Because these predictions have about the same level of accuracy as typical bioinformatics methods, and do not utilize information from databases of known native structures, this work opens up the possibility of predicting the structures of membrane proteins, synthetic peptides, or other foldable polymers, for which there is little prior knowledge of native structures. This approach may also be useful for predicting physical protein folding routes, non-native conformations, and other physical properties from amino acid sequences. PMID:19186130

  18. Reliability-Based Structural Optimization of Wave Energy Converters

    Directory of Open Access Journals (Sweden)

    Simon Ambühl

    2014-12-01

    Full Text Available More and more wave energy converter (WEC concepts are reaching prototypelevel. Once the prototype level is reached, the next step in order to further decrease thelevelized cost of energy (LCOE is optimizing the overall system with a focus on structuraland maintenance (inspection costs, as well as on the harvested power from the waves.The target of a fully-developed WEC technology is not maximizing its power output,but minimizing the resulting LCOE. This paper presents a methodology to optimize thestructural design of WECs based on a reliability-based optimization problem and the intentto maximize the investor’s benefits by maximizing the difference between income (e.g., fromselling electricity and the expected expenses (e.g., structural building costs or failure costs.Furthermore, different development levels, like prototype or commercial devices, may havedifferent main objectives and will be located at different locations, as well as receive varioussubsidies. These points should be accounted for when performing structural optimizationsof WECs. An illustrative example on the gravity-based foundation of the Wavestar deviceis performed showing how structural design can be optimized taking target reliability levelsand different structural failure modes due to extreme loads into account.

  19. Valence band electronic structure of Pd based ternary chalcogenide superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Lohani, H. [Institute of Physics, Sachivalaya Marg, Bhubaneswar 751005 (India); Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400085 (India); Mishra, P. [Institute of Physics, Sachivalaya Marg, Bhubaneswar 751005 (India); Goyal, R.; Awana, V.P.S. [National Physical Laboratory(CSIR), Dr. K. S. Krishnan Road, New Delhi 110012 (India); Sekhar, B.R., E-mail: sekhar@iopb.res.in [Institute of Physics, Sachivalaya Marg, Bhubaneswar 751005 (India); Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400085 (India)

    2016-12-15

    Highlights: • VB Photoemission study and DFT calculations on Pd based ternary superconductors are presented. • Nb{sub 2}Pd{sub 0.95}S{sub 5} shows a temperature dependent pseudogap. • VB spectral features of ternary superconductors are correlated to their structural geometry. - Abstract: We present a comparative study of the valence band electronic structure of Pd based ternary chalcogenide superconductors Nb{sub 2}Pd{sub 0.95}S{sub 5}, Ta{sub 2}Pd{sub 0.97}S{sub 6} and Ta{sub 2}Pd{sub 0.97}Te{sub 6} using experimental photoemission spectroscopy and density functional based theoretical calculations. We observe a qualitatively similarity between valence band (VB) spectra of Nb{sub 2}Pd{sub 0.95}S{sub 5} and Ta{sub 2}Pd{sub 0.97}S{sub 6}. Further, we find a pseudogap feature in Nb{sub 2}Pd{sub 0.95}S{sub 5} at low temperature, unlike other two compounds. We have correlated the structural geometry with the differences in VB spectra of these compounds. The different atomic packing in these compounds could vary the strength of inter-orbital hybridization among various atoms which leads to difference in their electronic structure as clearly observed in our DOS calculations.

  20. Processos dependentes de informação em empresas incubadas e graduadas de base tecnológica: um estudo comparativo de casos

    Directory of Open Access Journals (Sweden)

    Thais Elaine Vick

    Full Text Available A competitividade, atualmente, introduz novos comportamentos e leva empresas a uma situação de desconforto e, muitas vezes, a não adaptação às exigências ambientais. Percebe-se um crescente número de desafios associados com o controle de informação em organizações com atividades de engenharia, em particular os volumes crescentes de informação de natureza continuamente mutável. Pode-se afirmar que o desempenho inovador de uma organização é diretamente proporcional a sua capacidade de gerenciar informações. Desta forma, a importância da gestão da informação é reconhecida em detrimento da procura de meios mais competentes para atender demandas atuais. O artigo teve como propósito analisar doze processos dependentes de informação em empresas de base tecnológica, através das principais fases do processo de gerenciamento da informação. Optou-se pelo emprego do método comparativo de casos e pela pesquisa qualitativa, realizada em nove empresas de base tecnológica, as quais se encontravam incubadas ou que passaram recentemente pela fase de incubação no Parque Tecnológico da cidade de São Carlos, do estado de São Paulo. Entre os principais resultados, constatou-se que, nas empresas graduadas, a gestão da informação e seus procedimentos foram identificados de forma mais consciente e estruturados em relação às empresas incubadas.

  1. Optimization of morphing flaps based on fluid structure interaction modeling

    DEFF Research Database (Denmark)

    Barlas, Athanasios; Akay, Busra

    2018-01-01

    This article describes the design optimization of morphing trailing edge flaps for wind turbines with ‘smart blades’. A high fidelity Fluid Structure Interaction (FSI) simulation framework is utilized, comprised of 2D Finite Element Analysis (FEA) and Computational Fluid Dynamics (CFD) models....... A coupled aero-structural simulation of a 10% chordwise length morphing trailing edge flap for a 4 MW wind turbine rotor is carried out and response surfaces are produced with respect to the flap internal geometry design parameters for the design conditions. Surrogate model based optimization is applied...

  2. Bending-active reciprocal structures based on equilateral polyhedral geometries

    DEFF Research Database (Denmark)

    Popovic Larsen, Olga; BRANCART, Stijn; DE TEMMERMAN, Niels

    2017-01-01

    As mutually supported beam structures, reciprocal frames limit the number of components that are joined at each connection to two. However, this system of intermediate connections introduces undesirable bending moments in the beam elements. By utilising elastic deformation to create curved...... of parts of reciprocal bending-active components based on a selection of polyhedral dome types. To simplify the assembly of the structures and avoid the manual bending of the components on site, we introduce the concept of a double-layered, pre-bent component. Finally, this paper presents the development...

  3. Qrator: A web-based curation tool for glycan structures

    Science.gov (United States)

    Eavenson, Matthew; Kochut, Krys J; Miller, John A; Ranzinger, René; Tiemeyer, Michael; Aoki, Kazuhiro; York, William S

    2015-01-01

    Most currently available glycan structure databases use their own proprietary structure representation schema and contain numerous annotation errors. These cause problems when glycan databases are used for the annotation or mining of data generated in the laboratory. Due to the complexity of glycan structures, curating these databases is often a tedious and labor-intensive process. However, rigorously validating glycan structures can be made easier with a curation workflow that incorporates a structure-matching algorithm that compares candidate glycans to a canonical tree that embodies structural features consistent with established mechanisms for the biosynthesis of a particular class of glycans. To this end, we have implemented Qrator, a web-based application that uses a combination of external literature and database references, user annotations and canonical trees to assist and guide researchers in making informed decisions while curating glycans. Using this application, we have started the curation of large numbers of N-glycans, O-glycans and glycosphingolipids. Our curation workflow allows creating and extending canonical trees for these classes of glycans, which have subsequently been used to improve the curation workflow. PMID:25165068

  4. Particle filtering based structural assessment with acoustic emission sensing

    Science.gov (United States)

    Yan, Wuzhao; Abdelrahman, Marwa; Zhang, Bin; Ziehl, Paul

    2017-02-01

    Nuclear structures are designed to withstand severe loading events under various stresses. Over time, aging of structural systems constructed with concrete and steel will occur. This deterioration may reduce service life of nuclear facilities and/or lead to unnecessary or untimely repairs. Therefore, online monitoring of structures in nuclear power plants and waste storage has drawn significant attention in recent years. Of many existing non-destructive evaluation and structural monitoring approaches, acoustic emission is promising for assessment of structural damage because it is non-intrusive and is sensitive to corrosion and crack growth in reinforced concrete elements. To provide a rapid, actionable, and graphical means for interpretation Intensity Analysis plots have been developed. This approach provides a means for classification of damage. Since the acoustic emission measurement is only an indirect indicator of structural damage, potentially corrupted by non-genuine data, it is more suitable to estimate the states of corrosion and cracking in a Bayesian estimation framework. In this paper, we will utilize the accelerated corrosion data from a specimen at the University of South Carolina to develop a particle filtering-based diagnosis and prognosis algorithm. Promising features of the proposed algorithm are described in terms of corrosion state estimation and prediction of degradation over time to a predefined threshold.

  5. Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors

    Czech Academy of Sciences Publication Activity Database

    Pachl, Petr; Fábry, Milan; Rosenberg, Ivan; Šimák, Ondřej; Řezáčová, Pavlína; Brynda, Jiří

    2014-01-01

    Roč. 70, February (2014), s. 461-470 ISSN 0907-4449 R&D Projects: GA ČR GA203/09/0820 Institutional support: RVO:68378050 ; RVO:61388963 Keywords : 5′(3′)-deoxyribonucleotidases * enzyme inhibition * hydrolases * structure-based drug design Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 7.232, year: 2013

  6. Moire-Fringe-Based Fiber Optic Tiltmeter for Structural Health Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Dae Hyun [Seoul National of Technology, Seoul (Korea, Republic of)

    2008-04-15

    This paper presents a novel fiber optic tiltmeter system for the health monitoring of large-size structures. The system is composed of a sensor head, a light control unit and a signal processing unit. The sensing mechanism of the sensor head is based on a novel integration of the moire fringe phenomenon with fiber optics to achieve a robust performance in addition to its immunity to EM interference, easy ratting, and low cost. In this paper, a prototype of the fiber optic tiltmeter system has been developed successfully. A low-cost light control unit has been developed to drive the system's optic and electronic components. From an experimental test, the fiber optic tiltmeter is proven to be a prospective sensor for the monitoring of the tilting angle of civil structure with a good linearity. Finally, the test also successfully demonstrates the performance and the potential of the novel fiber optic tiltmeter system to monitor the health of civil infrastructures.

  7. Estrutura populacional de Pinus elliottii em áreas de regeneração florestal em Juiz de Fora, MG Population structure of Pinus elliottii in areas of forest regeneration in Juiz de Fora, MG, Brazil

    Directory of Open Access Journals (Sweden)

    Talita Aperibense Menon

    2012-12-01

    Full Text Available Plantas do gênero Pinus são conhecidas pelo potencial de invasão biológica. O Campus da Universidade Federal de Juiz de Fora (UFJF foi arborizado na década de 1960 com o plantio massivo de Pinus elliottii, e hoje a espécie está alastrada. Neste estudo, realizado no Campus da UFJF, Juiz de Fora, MG foi analisada a estrutura populacional da espécie em dois ambientes de regeneração florestal: aberto (pastagem abandonada e fechado (floresta secundária. Partiu-se da premissa que o ambiente aberto apresentaria uma população mais estruturada, pela preferência da espécie por áreas abertas. A amostragem foi por parcelas aleatórias (15 parcelas de 5 m x 5 m em cada ambiente, onde foram medidos todos os indivíduos da espécie (árvores: DAP ≥ 5 cm; arvoretas: DAP 0,05 com as variáveis ambientais indicou que a competição por recursos com a vegetação nativa não é um problema aparente para a permanência da espécie. Plants of the genus Pinus are known worldwide by biological invasion potential. In the 1960s there were massive plantations of Pinus elliottii in the Campus of Juiz de Fora University, and nowadays the species is widespread. This study analyzed the species population structure in two distinct forest regeneration environments: open area (abandoned pasture and closed-canopy (secondary forest on the campus of UFJF, Juiz de Fora, MG, Brazil. The hypothesis were that the open environment would present a better structured population, due to the preference of species for open areas. Random plots were allocated (15 plots of 5 m x 5 m in each environment, and all individuals of the species (trees: dbh . 5 cm, saplings, dbh 0.05 with environmental variables showed that competition for resources within the local vegetation is not an apparent problem for the permanence of species.

  8. Multiple functional roles of the accessory I-domain of bacteriophage P22 coat protein revealed by NMR structure and CryoEM modeling.

    Science.gov (United States)

    Rizzo, Alessandro A; Suhanovsky, Margaret M; Baker, Matthew L; Fraser, LaTasha C R; Jones, Lisa M; Rempel, Don L; Gross, Michael L; Chiu, Wah; Alexandrescu, Andrei T; Teschke, Carolyn M

    2014-06-10

    Some capsid proteins built on the ubiquitous HK97-fold have accessory domains imparting specific functions. Bacteriophage P22 coat protein has a unique insertion domain (I-domain). Two prior I-domain models from subnanometer cryoelectron microscopy (cryoEM) reconstructions differed substantially. Therefore, the I-domain's nuclear magnetic resonance structure was determined and also used to improve cryoEM models of coat protein. The I-domain has an antiparallel six-stranded β-barrel fold, not previously observed in HK97-fold accessory domains. The D-loop, which is dynamic in the isolated I-domain and intact monomeric coat protein, forms stabilizing salt bridges between adjacent capsomers in procapsids. The S-loop is important for capsid size determination, likely through intrasubunit interactions. Ten of 18 coat protein temperature-sensitive-folding substitutions are in the I-domain, indicating its importance in folding and stability. Several are found on a positively charged face of the β-barrel that anchors the I-domain to a negatively charged surface of the coat protein HK97-core. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Estrutura de uma floresta brejosa em substrato turfoso, Sul de Santa Catarina, Brasil Structure of a swamp forests on peat substrates, south of Santa Catarina, Brazil

    Directory of Open Access Journals (Sweden)

    Rafael Martins

    2013-04-01

    Full Text Available Objetivou-se descrever a diversidade e a estrutura do componente lenhoso de uma floresta brejosa em substrato turfoso no sul do Estado de Santa Catarina, correlacionando dados florísticos com variáveis ambientais. Indivíduos com DAP ≥ 5 cm foram amostrados em 100 parcelas de 10 x 10 m em um quadrado permanente de 1 ha. As variáveis ambientais foram classificadas em topográficas, químicas e texturais do solo e de luminosidade. Correlações espécie-ambiente foram obtidas por Análise de Correspondência Canônica (CCA. Comparações florísticas foram realizadas por análise de agrupamento (UPGMA e análise de correspondência. A diversidade específica foi considerada baixa, pois foram amostradas apenas 26 espécies. A CCA evidenciou que as variáveis ambientais mensuradas possuem pouca influência na distribuição das espécies, ressaltando assim sua adaptação ao ambiente anóxico, fortemente limitante. Dados de similaridade demonstraram que o substrato turfoso age como um filtro ambiental adicional, além do estresse hídrico, na composição de espécies nas formações turfosas/brejosas.This study aimed to describe the diversity and structure of woody vegetation of a swamp forests on peat substrate in the southern state of Santa Catarina, correlating floristic data with environmental variables. Individuals with DBH < 5 cm were sampled in 100 plots of 10 x 10 m in one hectare squared plot. Environmental variables are classified in topographical, chemical and soil texture and light availability. Species-environment correlations were obtained by Canonical Correspondence Analysis (CCA. Floristic comparisons were performed by cluster (UPGMA and correspondence analysis. Diversity was considered low because of the occurrence only 26 species in the whole sample. The CCA revealed that the measured variables have little influence on the distribution of species, highlighting the adaptation of these strong limiting environment. Similarity

  10. Steel catenary riser design based on coupled analysis methodology; Projeto de um riser rigido em catenaria baseado em metodologia de analise acoplada

    Energy Technology Data Exchange (ETDEWEB)

    Bahiense, Rodrigo A.; Rodrigues, Marcos V. [Det Norske Veritas (DNV), Rio de Janeiro, RJ (Brazil)

    2008-07-01

    Due to adoption of oil and gas production systems to deep and ultra-deep water, achieving frontiers that were not conceivable before, research in computational methods has contributed to implementation of sophisticated and efficient numerical tools in order to perform simulations considering those operational conditions. Thus, this work presents a steel catenary riser (SCR) design which is connected to a semi-submersible platform where the applied motions to SCR are obtained from analyses based on de-coupled and coupled methodologies. With increase of the line number of the system and water depth, the effects due to coupling of the lines on the platform motions are significant. It can be observed from performed evaluations for a floating production system, comparing the obtained results for SCR under extreme and fatigue conditions when it was submitted to the platform motions considering both methodologies mentioned. So, from the results obtained it can be concluded that for production system evaluated the adoption of decoupled methodology presents more conservative results. Thus the adoption of the coupled model associated to design practice of production lines presents as an alternative more realist and accurate to provide the optimization in the design of these structures. (author)

  11. Integrated Teaching of Structure-Based Drug Design and Biopharmaceutics: A Computer-Based Approach

    Science.gov (United States)

    Sutch, Brian T.; Romero, Rebecca M.; Neamati, Nouri; Haworth, Ian S.

    2012-01-01

    Rational drug design requires expertise in structural biology, medicinal chemistry, physiology, and related fields. In teaching structure-based drug design, it is important to develop an understanding of the need for early recognition of molecules with "drug-like" properties as a key component. That is, it is not merely sufficient to teach…

  12. Diode rectifier bridge-based structure for DFIG-based wind turbine

    DEFF Research Database (Denmark)

    Zhu, Rongwu; Chen, Zhe; Wu, Xiaojie

    2015-01-01

    This paper proposes a new structure for the doubly-fed induction generator (DFIG)-based wind turbine. The proposed structure consists of a DFIG controlled by a partial rated power converter in the rotor side, a three-phase diode rectifier bridge (DRB) connected to the stator, and a DC/AC full rated...

  13. Simulation tools for guided wave based structural health monitoring

    Science.gov (United States)

    Mesnil, Olivier; Imperiale, Alexandre; Demaldent, Edouard; Baronian, Vahan; Chapuis, Bastien

    2018-04-01

    Structural Health Monitoring (SHM) is a thematic derived from Non Destructive Evaluation (NDE) based on the integration of sensors onto or into a structure in order to monitor its health without disturbing its regular operating cycle. Guided wave based SHM relies on the propagation of guided waves in plate-like or extruded structures. Using piezoelectric transducers to generate and receive guided waves is one of the most widely accepted paradigms due to the low cost and low weight of those sensors. A wide range of techniques for flaw detection based on the aforementioned setup is available in the literature but very few of these techniques have found industrial applications yet. A major difficulty comes from the sensitivity of guided waves to a substantial number of parameters such as the temperature or geometrical singularities, making guided wave measurement difficult to analyze. In order to apply guided wave based SHM techniques to a wider spectrum of applications and to transfer those techniques to the industry, the CEA LIST develops novel numerical methods. These methods facilitate the evaluation of the robustness of SHM techniques for multiple applicative cases and ease the analysis of the influence of various parameters, such as sensors positioning or environmental conditions. The first numerical tool is the guided wave module integrated to the commercial software CIVA, relying on a hybrid modal-finite element formulation to compute the guided wave response of perturbations (cavities, flaws…) in extruded structures of arbitrary cross section such as rails or pipes. The second numerical tool is based on the spectral element method [2] and simulates guided waves in both isotropic (metals) and orthotropic (composites) plate like-structures. This tool is designed to match the widely accepted sparse piezoelectric transducer array SHM configuration in which each embedded sensor acts as both emitter and receiver of guided waves. This tool is under development and

  14. Experimental demonstration of dielectric structure based two beam acceleration

    International Nuclear Information System (INIS)

    Gai, W.; Conde, M. E.; Konecny, R.; Power, J. G.; Schoessow, P.; Sun, X.; Zou, P.

    2000-01-01

    We report on the experimental results of the dielectric based two beam accelerator (step-up transformer). By using a single high charge beam, we have generated and extracted a high power RF pulse from a 7.8 GHz primary dielectric structure and then subsequently transferred to a second accelerating structure with higher dielectric constant and smaller transverse dimensions. We have measured the energy change of a second (witness) beam passing through the acceleration stage. The measured gradient is >4 times the deceleration gradient. The detailed experiment of set-up and results of the measurements are dimmed. Future plans for the development of a 100 MeV demonstration accelerator based on this technique is presented

  15. Rotational stellar structures based on the Lagrangian variational principle

    International Nuclear Information System (INIS)

    Yasutake, Nobutoshi; Fujisawa, Kotaro; Yamada, Shoichi

    2017-01-01

    A new method for multi-dimensional stellar structures is proposed in this study. As for stellar evolution calculations, the Heney method is the defacto standard now, but basically assumed to be spherical symmetric. It is one of the difficulties for deformed stellar-evolution calculations to trace the potentially complex movements of each fluid element. On the other hand, our new method is very suitable to follow such movements, since it is based on the Lagrange coordinate. This scheme is also based on the variational principle, which is adopted to the studies for the pasta structures inside of neutron stars. Our scheme could be a major break through for evolution calculations of any types of deformed stars: proto-planets, proto-stars, and proto-neutron stars, etc. (paper)

  16. Rotational stellar structures based on the Lagrangian variational principle

    Science.gov (United States)

    Yasutake, Nobutoshi; Fujisawa, Kotaro; Yamada, Shoichi

    2017-06-01

    A new method for multi-dimensional stellar structures is proposed in this study. As for stellar evolution calculations, the Heney method is the defacto standard now, but basically assumed to be spherical symmetric. It is one of the difficulties for deformed stellar-evolution calculations to trace the potentially complex movements of each fluid element. On the other hand, our new method is very suitable to follow such movements, since it is based on the Lagrange coordinate. This scheme is also based on the variational principle, which is adopted to the studies for the pasta structures inside of neutron stars. Our scheme could be a major break through for evolution calculations of any types of deformed stars: proto-planets, proto-stars, and proto-neutron stars, etc.

  17. Structure-Based Virtual Screening of Commercially Available Compound Libraries.

    Science.gov (United States)

    Kireev, Dmitri

    2016-01-01

    Virtual screening (VS) is an efficient hit-finding tool. Its distinctive strength is that it allows one to screen compound libraries that are not available in the lab. Moreover, structure-based (SB) VS also enables an understanding of how the hit compounds bind the protein target, thus laying ground work for the rational hit-to-lead progression. SBVS requires a very limited experimental effort and is particularly well suited for academic labs and small biotech companies that, unlike pharmaceutical companies, do not have physical access to quality small-molecule libraries. Here, we describe SBVS of commercial compound libraries for Mer kinase inhibitors. The screening protocol relies on the docking algorithm Glide complemented by a post-docking filter based on structural protein-ligand interaction fingerprints (SPLIF).

  18. Experimental demonstration of dielectric structure based two beam acceleration.

    Energy Technology Data Exchange (ETDEWEB)

    Gai, W.; Conde, M. E.; Konecny, R.; Power, J. G.; Schoessow, P.; Sun, X.; Zou, P.

    2000-11-28

    We report on the experimental results of the dielectric based two beam accelerator (step-up transformer). By using a single high charge beam, we have generated and extracted a high power RF pulse from a 7.8 GHz primary dielectric structure and then subsequently transferred to a second accelerating structure with higher dielectric constant and smaller transverse dimensions. We have measured the energy change of a second (witness) beam passing through the acceleration stage. The measured gradient is >4 times the deceleration gradient. The detailed experiment of set-up and results of the measurements are dimmed. Future plans for the development of a 100 MeV demonstration accelerator based on this technique is presented.

  19. Structural system identification based on variational mode decomposition

    Science.gov (United States)

    Bagheri, Abdollah; Ozbulut, Osman E.; Harris, Devin K.

    2018-03-01

    In this paper, a new structural identification method is proposed to identify the modal properties of engineering structures based on dynamic response decomposition using the variational mode decomposition (VMD). The VMD approach is a decomposition algorithm that has been developed as a means to overcome some of the drawbacks and limitations of the empirical mode decomposition method. The VMD-based modal identification algorithm decomposes the acceleration signal into a series of distinct modal responses and their respective center frequencies, such that when combined their cumulative modal responses reproduce the original acceleration response. The decaying amplitude of the extracted modal responses is then used to identify the modal damping ratios using a linear fitting function on modal response data. Finally, after extracting modal responses from available sensors, the mode shape vector for each of the decomposed modes in the system is identified from all obtained modal response data. To demonstrate the efficiency of the algorithm, a series of numerical, laboratory, and field case studies were evaluated. The laboratory case study utilized the vibration response of a three-story shear frame, whereas the field study leveraged the ambient vibration response of a pedestrian bridge to characterize the modal properties of the structure. The modal properties of the shear frame were computed using analytical approach for a comparison with the experimental modal frequencies. Results from these case studies demonstrated that the proposed method is efficient and accurate in identifying modal data of the structures.

  20. Structural design systems using knowledge-based techniques

    International Nuclear Information System (INIS)

    Orsborn, K.

    1993-01-01

    Engineering information management and the corresponding information systems are of a strategic importance for industrial enterprises. This thesis treats the interdisciplinary field of designing computing systems for structural design and analysis using knowledge-based techniques. Specific conceptual models have been designed for representing the structure and the process of objects and activities in a structural design and analysis domain. In this thesis, it is shown how domain knowledge can be structured along several classification principles in order to reduce complexity and increase flexibility. By increasing the conceptual level of the problem description and representation of the domain knowledge in a declarative form, it is possible to enhance the development, maintenance and use of software for mechanical engineering. This will result in a corresponding increase of the efficiency of the mechanical engineering design process. These ideas together with the rule-based control point out the leverage of declarative knowledge representation within this domain. Used appropriately, a declarative knowledge representation preserves information better, is more problem-oriented and change-tolerant than procedural representations. 74 refs

  1. Structural health monitoring methodology for aircraft condition-based maintenance

    Science.gov (United States)

    Saniger, Jordi; Reithler, Livier; Guedra-Degeorges, Didier; Takeda, Nobuo; Dupuis, Jean Pierre

    2001-06-01

    Reducing maintenance costs while keeping a constant level of safety is a major issue for Air Forces and airlines. The long term perspective is to implement condition based maintenance to guarantee a constant safety level while decreasing maintenance costs. On this purpose, the development of a generalized Structural Health Monitoring System (SHMS) is needed. The objective of such a system is to localize the damages and to assess their severity, with enough accuracy to allow low cost corrective actions. The present paper describes a SHMS based on acoustic emission technology. This choice was driven by its reliability and wide use in the aerospace industry. The described SHMS uses a new learning methodology which relies on the generation of artificial acoustic emission events on the structure and an acoustic emission sensor network. The calibrated acoustic emission events picked up by the sensors constitute the knowledge set that the system relies on. With this methodology, the anisotropy of composite structures is taken into account, thus avoiding the major cause of errors of classical localization methods. Moreover, it is adaptive to different structures as it does not rely on any particular model but on measured data. The acquired data is processed and the event's location and corrected amplitude are computed. The methodology has been demonstrated and experimental tests on elementary samples presented a degree of accuracy of 1cm.

  2. A protein relational database and protein family knowledge bases to facilitate structure-based design analyses.

    Science.gov (United States)

    Mobilio, Dominick; Walker, Gary; Brooijmans, Natasja; Nilakantan, Ramaswamy; Denny, R Aldrin; Dejoannis, Jason; Feyfant, Eric; Kowticwar, Rupesh K; Mankala, Jyoti; Palli, Satish; Punyamantula, Sairam; Tatipally, Maneesh; John, Reji K; Humblet, Christine

    2010-08-01

    The Protein Data Bank is the most comprehensive source of experimental macromolecular structures. It can, however, be difficult at times to locate relevant structures with the Protein Data Bank search interface. This is particularly true when searching for complexes containing specific interactions between protein and ligand atoms. Moreover, searching within a family of proteins can be tedious. For example, one cannot search for some conserved residue as residue numbers vary across structures. We describe herein three databases, Protein Relational Database, Kinase Knowledge Base, and Matrix Metalloproteinase Knowledge Base, containing protein structures from the Protein Data Bank. In Protein Relational Database, atom-atom distances between protein and ligand have been precalculated allowing for millisecond retrieval based on atom identity and distance constraints. Ring centroids, centroid-centroid and centroid-atom distances and angles have also been included permitting queries for pi-stacking interactions and other structural motifs involving rings. Other geometric features can be searched through the inclusion of residue pair and triplet distances. In Kinase Knowledge Base and Matrix Metalloproteinase Knowledge Base, the catalytic domains have been aligned into common residue numbering schemes. Thus, by searching across Protein Relational Database and Kinase Knowledge Base, one can easily retrieve structures wherein, for example, a ligand of interest is making contact with the gatekeeper residue.

  3. SABATPG-A Structural Analysis Based Automatic Test Generation System

    Institute of Scientific and Technical Information of China (English)

    李忠诚; 潘榆奇; 闵应骅

    1994-01-01

    A TPG system, SABATPG, is given based on a generic structural model of large circuits. Three techniques of partial implication, aftereffect of identified undetectable faults and shared sensitization with new concepts of localization and aftereffect are employed in the system to improve FAN algorithm. Experiments for the 10 ISCAS benchmark circuits show that the computing time of SABATPG for test generation is 19.42% less than that of FAN algorithm.

  4. Automated Glioblastoma Segmentation Based on a Multiparametric Structured Unsupervised Classification

    Science.gov (United States)

    Juan-Albarracín, Javier; Fuster-Garcia, Elies; Manjón, José V.; Robles, Montserrat; Aparici, F.; Martí-Bonmatí, L.; García-Gómez, Juan M.

    2015-01-01

    Automatic brain tumour segmentation has become a key component for the future of brain tumour treatment. Currently, most of brain tumour segmentation approaches arise from the supervised learning standpoint, which requires a labelled training dataset from which to infer the models of the classes. The performance of these models is directly determined by the size and quality of the training corpus, whose retrieval becomes a tedious and time-consuming task. On the other hand, unsupervised approaches avoid these limitations but often do not reach comparable results than the supervised methods. In this sense, we propose an automated unsupervised method for brain tumour segmentation based on anatomical Magnetic Resonance (MR) images. Four unsupervised classification algorithms, grouped by their structured or non-structured condition, were evaluated within our pipeline. Considering the non-structured algorithms, we evaluated K-means, Fuzzy K-means and Gaussian Mixture Model (GMM), whereas as structured classification algorithms we evaluated Gaussian Hidden Markov Random Field (GHMRF). An automated postprocess based on a statistical approach supported by tissue probability maps is proposed to automatically identify the tumour classes after the segmentations. We evaluated our brain tumour segmentation method with the public BRAin Tumor Segmentation (BRATS) 2013 Test and Leaderboard datasets. Our approach based on the GMM model improves the results obtained by most of the supervised methods evaluated with the Leaderboard set and reaches the second position in the ranking. Our variant based on the GHMRF achieves the first position in the Test ranking of the unsupervised approaches and the seventh position in the general Test ranking, which confirms the method as a viable alternative for brain tumour segmentation. PMID:25978453

  5. From crystal to compound: structure-based antimalarial drug discovery.

    Science.gov (United States)

    Drinkwater, Nyssa; McGowan, Sheena

    2014-08-01

    Despite a century of control and eradication campaigns, malaria remains one of the world's most devastating diseases. Our once-powerful therapeutic weapons are losing the war against the Plasmodium parasite, whose ability to rapidly develop and spread drug resistance hamper past and present malaria-control efforts. Finding new and effective treatments for malaria is now a top global health priority, fuelling an increase in funding and promoting open-source collaborations between researchers and pharmaceutical consortia around the world. The result of this is rapid advances in drug discovery approaches and technologies, with three major methods for antimalarial drug development emerging: (i) chemistry-based, (ii) target-based, and (iii) cell-based. Common to all three of these approaches is the unique ability of structural biology to inform and accelerate drug development. Where possible, SBDD (structure-based drug discovery) is a foundation for antimalarial drug development programmes, and has been invaluable to the development of a number of current pre-clinical and clinical candidates. However, as we expand our understanding of the malarial life cycle and mechanisms of resistance development, SBDD as a field must continue to evolve in order to develop compounds that adhere to the ideal characteristics for novel antimalarial therapeutics and to avoid high attrition rates pre- and post-clinic. In the present review, we aim to examine the contribution that SBDD has made to current antimalarial drug development efforts, covering hit discovery to lead optimization and prevention of parasite resistance. Finally, the potential for structural biology, particularly high-throughput structural genomics programmes, to identify future targets for drug discovery are discussed.

  6. Electronic structure of ternary hydrides based on light elements

    Energy Technology Data Exchange (ETDEWEB)

    Orgaz, E. [Departamento de Fisica y Quimica Teorica, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, CP 04510 Coyoacan, Mexico, D.F. (Mexico)]. E-mail: orgaz@eros.pquim.unam.mx; Membrillo, A. [Departamento de Fisica y Quimica Teorica, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, CP 04510 Coyoacan, Mexico, D.F. (Mexico); Castaneda, R. [Departamento de Fisica y Quimica Teorica, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, CP 04510 Coyoacan, Mexico, D.F. (Mexico); Aburto, A. [Departamento de Fisica, Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, CP 04510 Coyoacan, Mexico, D.F. (Mexico)

    2005-12-08

    Ternary hydrides based on light elements are interesting owing to the high available energy density. In this work we focused into the electronic structure of a series of known systems having the general formula AMH{sub 4}(A=Li,Na,M=B,Al). We computed the energy bands and the total and partial density of states using the linear-augmented plane waves method. In this report, we discuss the chemical bonding in this series of complex hydrides.

  7. Simulations for irradiation of silicon-based structures

    International Nuclear Information System (INIS)

    Sagatova, A.; Pavlovic, M.; Sedlackova, K.; Necas, V.; Hybler, P.; Zatko, B.

    2013-01-01

    The software ModePEB for modelling of electron beam processing in multilayer flat objects was shown to be a very useful tool for optimization of the irradiation of silicon based structures. Except its significant help in setting-up the accelerator parameters corresponding to a desired dose, its proven reliability and consistency with the measured data makes the ModePEB an inevitable instrument for design and optimization of electron irradiation experiments. (authors)

  8. Towards risk-based structural integrity methods for PWRs

    International Nuclear Information System (INIS)

    Chapman, O.J.V.; Lloyd, R.B.

    1992-01-01

    This paper describes the development of risk-based structural integrity assurance methods and their application to Pressurized Water Reactor (PWR) plant. In-service inspection is introduced as a way of reducing the failure probability of high risk sites and the latter are identified using reliability analysis; the extent and interval of inspection can also be optimized. The methodology is illustrated by reference to the aspect of reliability of weldments in PWR systems. (author)

  9. Grid-based electronic structure calculations: The tensor decomposition approach

    Energy Technology Data Exchange (ETDEWEB)

    Rakhuba, M.V., E-mail: rakhuba.m@gmail.com [Skolkovo Institute of Science and Technology, Novaya St. 100, 143025 Skolkovo, Moscow Region (Russian Federation); Oseledets, I.V., E-mail: i.oseledets@skoltech.ru [Skolkovo Institute of Science and Technology, Novaya St. 100, 143025 Skolkovo, Moscow Region (Russian Federation); Institute of Numerical Mathematics, Russian Academy of Sciences, Gubkina St. 8, 119333 Moscow (Russian Federation)

    2016-05-01

    We present a fully grid-based approach for solving Hartree–Fock and all-electron Kohn–Sham equations based on low-rank approximation of three-dimensional electron orbitals. Due to the low-rank structure the total complexity of the algorithm depends linearly with respect to the one-dimensional grid size. Linear complexity allows for the usage of fine grids, e.g. 8192{sup 3} and, thus, cheap extrapolation procedure. We test the proposed approach on closed-shell atoms up to the argon, several molecules and clusters of hydrogen atoms. All tests show systematical convergence with the required accuracy.

  10. A new entropy based method for computing software structural complexity

    International Nuclear Information System (INIS)

    Roca, Jose L.

    2002-01-01

    In this paper a new methodology for the evaluation of software structural complexity is described. It is based on the entropy evaluation of the random uniform response function associated with the so called software characteristic function SCF. The behavior of the SCF with the different software structures and their relationship with the number of inherent errors is investigated. It is also investigated how the entropy concept can be used to evaluate the complexity of a software structure considering the SCF as a canonical representation of the graph associated with the control flow diagram. The functions, parameters and algorithms that allow to carry out this evaluation are also introduced. After this analytic phase follows the experimental phase, verifying the consistency of the proposed metric and their boundary conditions. The conclusion is that the degree of software structural complexity can be measured as the entropy of the random uniform response function of the SCF. That entropy is in direct relationship with the number of inherent software errors and it implies a basic hazard failure rate for it, so that a minimum structure assures a certain stability and maturity of the program. This metric can be used, either to evaluate the product or the process of software development, as development tool or for monitoring the stability and the quality of the final product. (author)

  11. Module-based structure design of wheeled mobile robot

    Directory of Open Access Journals (Sweden)

    Z. Luo

    2018-02-01

    Full Text Available This paper proposes an innovative and systematic approach for synthesizing mechanical structures of wheeled mobile robots. The principle and terminologies used for the proposed synthesis method are presented by adopting the concept of modular design, isomorphic and non-isomorphic, and set theory with its associated combinatorial mathematics. The modular-based innovative synthesis and design of wheeled robots were conducted at two levels. Firstly at the module level, by creative design and analysing the structures of classic wheeled robots, a wheel module set containing four types of wheel mechanisms, a suspension module set consisting of five types of suspension frames and a chassis module set composed of five types of rigid or articulated chassis were designed and generalized. Secondly at the synthesis level, two kinds of structure synthesis modes, namely the isomorphic-combination mode and the non-isomorphic combination mode were proposed to synthesize mechanical structures of wheeled robots; which led to 241 structures for wheeled mobile robots including 236 novel ones. Further, mathematical models and a software platform were developed to provide appropriate and intuitive tools for simulating and evaluating performance of the wheeled robots that were proposed in this paper. Eventually, physical prototypes of sample wheeled robots/rovers were developed and tested so as to prove and validate the principle and methodology presented in this paper.

  12. Structural reliability analysis based on the cokriging technique

    International Nuclear Information System (INIS)

    Zhao Wei; Wang Wei; Dai Hongzhe; Xue Guofeng

    2010-01-01

    Approximation methods are widely used in structural reliability analysis because they are simple to create and provide explicit functional relationships between the responses and variables in stead of the implicit limit state function. Recently, the kriging method which is a semi-parameter interpolation technique that can be used for deterministic optimization and structural reliability has gained popularity. However, to fully exploit the kriging method, especially in high-dimensional problems, a large number of sample points should be generated to fill the design space and this can be very expensive and even impractical in practical engineering analysis. Therefore, in this paper, a new method-the cokriging method, which is an extension of kriging, is proposed to calculate the structural reliability. cokriging approximation incorporates secondary information such as the values of the gradients of the function being approximated. This paper explores the use of the cokriging method for structural reliability problems by comparing it with the Kriging method based on some numerical examples. The results indicate that the cokriging procedure described in this work can generate approximation models to improve on the accuracy and efficiency for structural reliability problems and is a viable alternative to the kriging.

  13. Reliability-Based Optimal Design for Very Large Floating Structure

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shu-hua(张淑华); FUJIKUBO Masahiko

    2003-01-01

    Costs and losses induced by possible future extreme environmental conditions and difficulties in repairing post-yielding damage strongly suggest the need for proper consideration in design rather than just life loss prevention. This can be addressed through the development of design methodology that balances the initial cost of the very large floating structure (VLFS) against the expected potential losses resulting from future extreme wave-induced structural damage. Here, the development of a methodology for determining optimal, cost-effective design will be presented and applied to a VLFS located in the Tokyo bay. Optimal design criteria are determined based on the total expected life-cycle cost and acceptable damage probability and curvature of the structure, and a set of sizes of the structure are obtained. The methodology and applications require expressions of the initial cost and the expected life-cycle damage cost as functions of the optimal design variables. This study includes the methodology, total life-cycle cost function, structural damage modeling, and reliability analysis.

  14. Crack width monitoring of concrete structures based on smart film

    International Nuclear Information System (INIS)

    Zhang, Benniu; Wang, Shuliang; Li, Xingxing; Zhang, Xu; Yang, Guang; Qiu, Minfeng

    2014-01-01

    Due to its direct link to structural security, crack width is thought to be one of the most important parameters reflecting damage conditions of concrete structures. However, the width problem is difficult to solve with the existing structural health monitoring methods. In this paper, crack width monitoring by means of adhering enameled copper wires with different ultimate strains on the surface of structures is proposed, based on smart film crack monitoring put forward by the present authors. The basic idea of the proposed method is related to a proportional relationship between the crack width and ultimate strain of the broken wire. Namely, when a certain width of crack passes through the wire, some low ultimate strain wires will be broken and higher ultimate strain wires may stay non-broken until the crack extends to a larger scale. Detection of the copper wire condition as broken or non-broken may indicate the width of the structural crack. Thereafter, a multi-layered stress transfer model and specimen experiment are performed to quantify the relationship. A practical smart film is then redesigned with this idea and applied to Chongqing Jiangjin Yangtze River Bridge. (paper)

  15. Crack width monitoring of concrete structures based on smart film

    Science.gov (United States)

    Zhang, Benniu; Wang, Shuliang; Li, Xingxing; Zhang, Xu; Yang, Guang; Qiu, Minfeng

    2014-04-01

    Due to its direct link to structural security, crack width is thought to be one of the most important parameters reflecting damage conditions of concrete structures. However, the width problem is difficult to solve with the existing structural health monitoring methods. In this paper, crack width monitoring by means of adhering enameled copper wires with different ultimate strains on the surface of structures is proposed, based on smart film crack monitoring put forward by the present authors. The basic idea of the proposed method is related to a proportional relationship between the crack width and ultimate strain of the broken wire. Namely, when a certain width of crack passes through the wire, some low ultimate strain wires will be broken and higher ultimate strain wires may stay non-broken until the crack extends to a larger scale. Detection of the copper wire condition as broken or non-broken may indicate the width of the structural crack. Thereafter, a multi-layered stress transfer model and specimen experiment are performed to quantify the relationship. A practical smart film is then redesigned with this idea and applied to Chongqing Jiangjin Yangtze River Bridge.

  16. Road Network Selection Based on Road Hierarchical Structure Control

    Directory of Open Access Journals (Sweden)

    HE Haiwei

    2015-04-01

    Full Text Available A new road network selection method based on hierarchical structure is studied. Firstly, road network is built as strokes which are then classified into hierarchical collections according to the criteria of betweenness centrality value (BC value. Secondly, the hierarchical structure of the strokes is enhanced using structural characteristic identification technique. Thirdly, the importance calculation model was established according to the relationships among the hierarchical structure of the strokes. Finally, the importance values of strokes are got supported with the model's hierarchical calculation, and with which the road network is selected. Tests are done to verify the advantage of this method by comparing it with other common stroke-oriented methods using three kinds of typical road network data. Comparision of the results show that this method had few need to semantic data, and could eliminate the negative influence of edge strokes caused by the criteria of BC value well. So, it is better to maintain the global hierarchical structure of road network, and suitable to meet with the selection of various kinds of road network at the same time.

  17. Depressive symptoms and motor performance in the elderly: a population based study Sintomas depressivos e desempenho motor em idosos: estudo de base populacional

    Directory of Open Access Journals (Sweden)

    Kleyton T. Santos

    2012-08-01

    Full Text Available BACKGROUND: There is a growing incidence of depression in the elderly, and this impairment interferes directly in the reduction of motor skills. OBJECTVE: This study aims to examine the association between depressive symptoms and motor performance in community-dwelling elderly. METHOD: This is a cross-sectional study that analyzed data from 316 elders of a home and population-based epidemiological survey. The information used was: socio-demographic characteristics; motor performance tests; physical activity; and Geriatric Depression Scale. The data were analyzed using the Statistical Package for Social Sciences. Mann-Whitney U test, chi-square, Spearman correlation and Poisson regression, with a confidence interval of 95%, were calculated. RESULTS: For all motor tests, motor performance was negatively associated with depressive symptoms, regardless of gender, age, literacy and illiteracy, per capita income and physical activity. Elderly people with depressive symptoms have between 58% and 82% more functional limitation, depending on the motor performance test compared to those who were not depressed. CONCLUSIONS: There is an inverse relationship between depressive symptoms and motor performance in the elderly.CONTEXTUALIZAÇÃO: É crescente a ocorrência de depressão em idosos, e esse acometimento interfere diretamente na redução da capacidade motora. OBJETIVO: Analisar a associação entre sintomas depressivos e desempenho motor em idosos residentes na comunidade. MÉTODO: Trata-se de um estudo transversal que analisou dados de 316 idosos de uma pesquisa epidemiológica de base domiciliar e populacional. As informações usadas foram: características sociodemográficas; testes de desempenho motor; atividade física e Escala de Depressão Geriátrica. Os dados foram analisados no The Statistical Package for Social Sciences, sendo realizados testes U de Mann-Whitney, qui-quadrado, Correlação de Spearman e regressão de Poisson, com

  18. Coupled vertical-rocking response of base-isolated structures

    International Nuclear Information System (INIS)

    Pan, T.C.; Kelly, J.M.

    1984-01-01

    A base-isolated building can have a small horizontal eccentricity between the center of mass of the superstructure and the center of rigidity of the supporting bearings. The structure can be modeled as a rigid block with tributary masses supported on massless rubber bearings placed at a constant elevation below the center of mass. Perturbation methods are implemented to find the dynamic characteristics for both the detuned and the perfectly tuned cases. The Green's functions for the displacement response of the system are derived for the undamped and the damped conditions. The response spectrum modal superposition method is used in estimating the maximum acceleration. A simple method, accounting for the effect of closely spaced modes, is proposed for combining modal maxima and results in an approximate single-degree-of-freedom solution. This approximate solution may be used for thepreliminary design of a base-isolated structure. Numerical results for a base-isolated building subjected to the vertical component of the El Centro earthquake of 1940 were carried out for comparison with analytical results. It is shown that the effect of rocking coupling on the vertical seismic response of baseisolated structures can generally be neglected because of the combined effects of the time lag between the maximum translational and rotational responses and the influence of damping in the isolation system

  19. Fragment approaches in structure-based drug discovery

    International Nuclear Information System (INIS)

    Hubbard, Roderick E.

    2008-01-01

    Fragment-based methods are successfully generating novel and selective drug-like inhibitors of protein targets, with a number of groups reporting compounds entering clinical trials. This paper summarizes the key features of the approach as one of the tools in structure-guided drug discovery. There has been considerable interest recently in what is known as 'fragment-based lead discovery'. The novel feature of the approach is to begin with small low-affinity compounds. The main advantage is that a larger potential chemical diversity can be sampled with fewer compounds, which is particularly important for new target classes. The approach relies on careful design of the fragment library, a method that can detect binding of the fragment to the protein target, determination of the structure of the fragment bound to the target, and the conventional use of structural information to guide compound optimization. In this article the methods are reviewed, and experiences in fragment-based discovery of lead series of compounds against kinases such as PDK1 and ATPases such as Hsp90 are discussed. The examples illustrate some of the key benefits and issues of the approach and also provide anecdotal examples of the patterns seen in selectivity and the binding mode of fragments across different protein targets

  20. Mechanical properties of a high amylose content corn starch based film, gelatinized at low temperature Propriedades mecânicas de filme a base de amido de milho de alto teor de amilose gelatinizado em baixa temperatura

    Directory of Open Access Journals (Sweden)

    Maria Alejandra Bertuzzi

    2012-09-01

    Full Text Available In the present study, a better knowledge of the influence of plasticizer content, storage relative humidity and film thickness on the mechanical properties of high amylose corn starch based films gelatinized at low temperature, is presented. The mechanical properties, tensile strength and percentage of elongation at break of high amylose corn starch films plasticized with glycerol were evaluated using tension tests. The films exhibited an increase in elongation and a decrease in tensile strength with increasing plasticizer concentration. When the glycerol level was high, some fissures were detected in the dry films, possible due to phase separation (starch-glycerol phenomena. Film crystallinity is related to the reorganization capacity of the polymer chain, and thus the relative film crystallinity should increase with plasticizer content (glycerol and water. The mechanical properties were found to be strongly dependent on the water content due to the hydrophilic nature of starch films. The influence of moisture sorption on tensile strength was similar to that of plasticization with glycerol. The relationship between polymer chain mobility and water content explained this behavior. Elongation suffered a different effect and maximum values were reached at 45% relative humidity. The final drop in elongation was due to a softening of the structure at high relative humidity. The thicker the film the longer the drying time required, leading to greater relative crystallinity due to the corresponding increase in the possibility for chain reorganization. As a consequence, linear increases in tensile strength and elongation were observed with film thickness over the whole range studied (30 to 100 µm.No presente estudo, é apresentado um melhor conhecimento da influência do teor em plastificante, da umidade relativa de armazenamento e da espessura do filme nas propriedades mecânicas do filme baseado em amido de milho de alto conteúdo de amilose

  1. O uso do custeio baseado em atividades: ABC (Activity Based Costing nas maiores empresas de Santa Catarina

    Directory of Open Access Journals (Sweden)

    Ilse Maria Beuren

    2002-12-01

    Full Text Available Devido à globalização da economia, as empresas evoluíram para a produção de enormes variedades de produtos personalizados. Com o intuito de atender às exigências dos clientes, surgiu a necessidade de grandes alterações nos processos tecnológicos. Como conseqüência, os custos indiretos passaram a ser mais significativos, o que implicou um novo método de distribuição desses custos, capaz de distribuir melhor os custos indiretos aos produtos e serviços. A esse método foi dado o nome de custeio baseado em atividades - ABC (Activity Based Costing. Esse método foi investigado por Carlos Yorghi Khoury em 1996, numa pesquisa aplicada às 500 maiores empresas do Brasil. O objetivo deste trabalho foi replicar essa pesquisa nas maiores empresas catarinenses, a fim de observar se esses resultados obtidos assemelham-se aos obtidos na pesquisa com as empresas catarinenses.Nesta pesquisa, dos 200 questionários enviados para as maiores empresas de Santa Catarina, 81 retornaram com as questões respondidas. O trabalho levou a conclusões importantes, como: as empresas de Santa Catarina têm amplo conhecimento do sistema ABC; algumas empresas que implantaram esse sistema já estão desistindo de seu uso, em função da complexidade para apropriar os custos indiretos e as despesas às atividades e estas aos produtos.Due to the economic globalization, enterprises have started to produce enormous varieties of personalized products. In order to attend to the requirements of their clients, huge changes in the technological process were needed. Consequently, indirect costs became more significant, which led to a new method for distributing the indirect costs, capable of better distributing the indirect costs of products and services.This method was called Activity Based Costing and was investigated by Carlos Yorghi Khoury in 1996 through a research applied in the 500 biggest companies in Brazil. This paper aims to replicate the 1996 research in the

  2. Frequency Response Function Based Damage Identification for Aerospace Structures

    Science.gov (United States)

    Oliver, Joseph Acton

    Structural health monitoring technologies continue to be pursued for aerospace structures in the interests of increased safety and, when combined with health prognosis, efficiency in life-cycle management. The current dissertation develops and validates damage identification technology as a critical component for structural health monitoring of aerospace structures and, in particular, composite unmanned aerial vehicles. The primary innovation is a statistical least-squares damage identification algorithm based in concepts of parameter estimation and model update. The algorithm uses frequency response function based residual force vectors derived from distributed vibration measurements to update a structural finite element model through statistically weighted least-squares minimization producing location and quantification of the damage, estimation uncertainty, and an updated model. Advantages compared to other approaches include robust applicability to systems which are heavily damped, large, and noisy, with a relatively low number of distributed measurement points compared to the number of analytical degrees-of-freedom of an associated analytical structural model (e.g., modal finite element model). Motivation, research objectives, and a dissertation summary are discussed in Chapter 1 followed by a literature review in Chapter 2. Chapter 3 gives background theory and the damage identification algorithm derivation followed by a study of fundamental algorithm behavior on a two degree-of-freedom mass-spring system with generalized damping. Chapter 4 investigates the impact of noise then successfully proves the algorithm against competing methods using an analytical eight degree-of-freedom mass-spring system with non-proportional structural damping. Chapter 5 extends use of the algorithm to finite element models, including solutions for numerical issues, approaches for modeling damping approximately in reduced coordinates, and analytical validation using a composite

  3. A probabilistic fragment-based protein structure prediction algorithm.

    Directory of Open Access Journals (Sweden)

    David Simoncini

    Full Text Available Conformational sampling is one of the bottlenecks in fragment-based protein structure prediction approaches. They generally start with a coarse-grained optimization where mainchain atoms and centroids of side chains are considered, followed by a fine-grained optimization with an all-atom representation of proteins. It is during this coarse-grained phase that fragment-based methods sample intensely the conformational space. If the native-like region is sampled more, the accuracy of the final all-atom predictions may be improved accordingly. In this work we present EdaFold, a new method for fragment-based protein structure prediction based on an Estimation of Distribution Algorithm. Fragment-based approaches build protein models by assembling short fragments from known protein structures. Whereas the probability mass functions over the fragment libraries are uniform in the usual case, we propose an algorithm that learns from previously generated decoys and steers the search toward native-like regions. A comparison with Rosetta AbInitio protocol shows that EdaFold is able to generate models with lower energies and to enhance the percentage of near-native coarse-grained decoys on a benchmark of [Formula: see text] proteins. The best coarse-grained models produced by both methods were refined into all-atom models and used in molecular replacement. All atom decoys produced out of EdaFold's decoy set reach high enough accuracy to solve the crystallographic phase problem by molecular replacement for some test proteins. EdaFold showed a higher success rate in molecular replacement when compared to Rosetta. Our study suggests that improving low resolution coarse-grained decoys allows computational methods to avoid subsequent sampling issues during all-atom refinement and to produce better all-atom models. EdaFold can be downloaded from http://www.riken.jp/zhangiru/software.html [corrected].

  4. Origem, prática educativa e evolução do movimento de educação de base (MEB em Itacoatiara - AM

    Directory of Open Access Journals (Sweden)

    Alderlene Lima de Souza

    2014-04-01

    Full Text Available Este estudo visou analisar a relevância do Movimento de Educação de Base (MEB, no município de Itacoatiara-AM, no período de 1998 a 2003. Tendo em vista o caráter político-pedagógico das práticas educativas forjadas por este movimento durante a sua 3ª fase a nível nacional. O Movimento de Educação de Base foi criado em 1961 pela Conferência Nacional dos Bispos do Brasil (CNBB. O objetivo principal do MEB era desenvolver um programa de educação de base, por meio de escolas radiofônicas, principalmente nas zonas rurais das áreas subdesenvolvidas do Norte, Nordeste e Centro-Oeste do país, expandindo-se posteriormente para outras regiões do Brasil de acordo com o decreto 5.2267/61. Assim, pautou-se a análise em fontes primárias (documentos que estão localizadas na Cúria Prelatícia da cidade. E também no levantamento bibliográfico, pois, é praticamente impossível desenvolver um estudo científico, sem a fundamentação em um ou mais pressupostos que direcionem a “reconstrução” do objeto. Apesar da diversidade de informações contida nos documentos, ainda são escassos os estudos que visam historiar o MEB da região Norte do país. Os dados da pesquisa apontam que, durante a atuação do MEB em Itacoatiara o rádio não era o principal meio de transmissão das aulas, os professores utilizavam cartilhas elaboradas pelo MEB de acordo com a realidade local.

  5. A Review of the Piezoelectric Electromechanical Impedance Based Structural Health Monitoring Technique for Engineering Structures

    Directory of Open Access Journals (Sweden)

    Wongi S. Na

    2018-04-01

    Full Text Available The birth of smart materials such as piezoelectric (PZT transducers has aided in revolutionizing the field of structural health monitoring (SHM based on non-destructive testing (NDT methods. While a relatively new NDT method known as the electromechanical (EMI technique has been investigated for more than two decades, there are still various problems that must be solved before it is applied to real structures. The technique, which has a significant potential to contribute to the creation of one of the most effective SHM systems, involves the use of a single PZT for exciting and sensing of the host structure. In this paper, studies applied for the past decade related to the EMI technique have been reviewed to understand its trend. In addition, new concepts and ideas proposed by various authors are also surveyed, and the paper concludes with a discussion of the potential directions for future works.

  6. SA-Search: a web tool for protein structure mining based on a Structural Alphabet.

    Science.gov (United States)

    Guyon, Frédéric; Camproux, Anne-Claude; Hochez, Joëlle; Tufféry, Pierre

    2004-07-01

    SA-Search is a web tool that can be used to mine for protein structures and extract structural similarities. It is based on a hidden Markov model derived Structural Alphabet (SA) that allows the compression of three-dimensional (3D) protein conformations into a one-dimensional (1D) representation using a limited number of prototype conformations. Using such a representation, classical methods developed for amino acid sequences can be employed. Currently, SA-Search permits the performance of fast 3D similarity searches such as the extraction of exact words using a suffix tree approach, and the search for fuzzy words viewed as a simple 1D sequence alignment problem. SA-Search is available at http://bioserv.rpbs.jussieu.fr/cgi-bin/SA-Search.

  7. Estrutura de espécies arbóreas sob efeito de borda em um fragmento de floresta estacional semidecidual em Pernambuco Edge effect on the structure of tree species in a seasonal forest fragment in Pernambuco

    Directory of Open Access Journals (Sweden)

    Alan Caue de Holanda

    2010-02-01

    Full Text Available Os fragmentos florestais são considerados os únicos redutos detentores de biodiversidade do planeta. Conhecer os processos que decorrem após a fragmentação, a exemplo da estrutura arbórea ocorrente na borda, é de fundamental importância para se proporem medidas conservacionistas. Os objetivos deste trabalho, desenvolvido em uma área de 83,8 ha, localizada no Município de Nazaré da Mata, PE, foram efetuar o levantamento fitossociológico de espécies arbóreas adultas sob efeito de borda e verificar a similaridade florística entre as parcelas. A área amostral foi de 10.000 m², equivalentes à implantação de 10 transectos de 10 x 100 m perpendiculares à borda, distribuídos de forma sistemática. Foram amostrados, etiquetados e identificados todos os indivíduos arbóreos com CAP e" 15 cm. Posteriormente, realizaram-se os cálculos dos parâmetros fitossociológicos e da similaridade florística. Neste estudo, amostraram-se 1.238 indivíduos, pertencentes a 72 táxons, distribuídos em 26 famílias botânicas. As espécies Campomanesia xanthocarpa, Zanthoxylum rhoifolium e Anadenanthera colubrina apresentaram o maior valor de importância, pois, teoricamente, conseguiram explorar melhor o recurso proporcionado pelo hábitat.Forest fragments are considered the last refuges for biodiversity in the planet. Knowing the processes that occur after fragmentation, such as the tree structure that occurs in the edge, is fundamental to propose conservationist measures. The objective of this work was to carry out a phytosociological survey of adult tree species under edge effect and verify the floristic similarity among the plots. The work was developed in an area of 83,8 ha located in the municipality of Nazaré da Mata - PE. The sample area comprised 10.000 m², equivalent to the implantation of 10 contiguous transects of 10 x 100 m perpendicular to the edge. All tree individuals with CAP e" 15 cm were sampled, labeled and identified

  8. Reliability-based inspection of prestressed concrete containment structures

    International Nuclear Information System (INIS)

    Pandey, M.D.

    1996-03-01

    A study was undertaken to develop a reliability-based approach to the planning of inspection programs for prestressed concrete containment structures. The main function of the prestressing system is to ensure the leak integrity of the containment by maintaining a compressive state of stress under the tensile forces which arise in a hypothesized loss of coolant accident. Prestressing force losses (due to creep and shrinkage, stress relaxation or tendon corrosion) can lead to tensile stresses under accident pressure, resulting in loss of containment leak integrity due to concrete cracking and tensile yielding of the non-prestressed reinforcement. Therefore, the evaluation of prestressing inspection programs was based on their effectiveness in maintaining an acceptable reliability level with respect to a limit state representing yeilding of non-prestressed reinforcement. An annual target reliability of 10 -4 was used for this limit state. As specified in CSA-N287.7, the evaluation of prestressing systems for containment structures is based on the results of lift-off tests to determine the prestressing force. For unbonded systems the tests are carried out on a randomly selected sample from each tendon group in the structure. For bonded systems, the test is carried out on an unbonded test beam that matches the section geometry and material properties of the containment structure. It was found that flexural testing is useful in updating the probability of concrete cracking under accident pressure. For unbonded systems, the analysis indicated that the sample size recommended by the CSA Standard (4% of the tendon population) is adequate. The CSA recommendation for a five year inspection interval is conservative unless severe degradation of the prestressing system, characterized by a high prestressing loss rate (>3%) and a large coefficient of variation of the measured prestressing force (>15%), is observed

  9. Evaluation of EM loads distribution on DEMO blanket segments and their effect on mechanical integrity

    International Nuclear Information System (INIS)

    Maione, Ivan Alessio; Zeile, Christian; Boccaccini, Lorenzo V.; Vaccaro, Alessandro

    2016-01-01

    Highlights: • Two DEMO 2015 ANSYS FEM models (for EM and structural analysis) have been implemented based on the EU-HCPB concept. • Lorentz’s forces have been calculated and their impact on the segment structure has been evaluated. • EM loads show a predominant total radial moment due to the high toroidal magnetic field (in comparison with the poloidal one). • A preliminary assessment of the primary stresses according the RCC-MRx code indicates the ability of the segments to resist the EM forces. - Abstract: This work is aimed to analyze the EM internal forces distribution on the blanket system (blankets modules and segment back supporting structure) of the EU PPPT DEMO 2015 reactor configuration. In order to validate their impact on the segment structure, an EM analysis is conducted using a simplified plasma central disruption. The calculated Lorentz’s forces distributions are then used as input for structural analyses focusing on the mechanical integrity of the segment back supporting structure. In particular, the electrical and structural assumptions used in this work are based on the HCPB blanket design developed at the Karlsruhe Institute of Technology. A preliminary assessment of the primary stresses according the design code RCC-MRx indicates the ability of the segments to resist the EM forces, where the lowest margin is given by the immediate plastic instability criterion on the inboard segment with 14%.

  10. International EMS Systems

    DEFF Research Database (Denmark)

    Langhelle, Audun; Lossius, Hans Morten; Silfvast, Tom

    2004-01-01

    exist, however, especially within the ground and air ambulance service, and the EMS systems face several challenges. Main problems and challenges emphasized by the authors are: (1) Denmark: the dispatch centres are presently not under medical control and are without a national criteria based system......Emergency medicine service (EMS) systems in the five Nordic countries have more similarities than differences. One similarity is the involvement of anaesthesiologists as pre-hospital physicians and their strong participation for all critically ill and injured patients in-hospital. Discrepancies do....... Access to on-line medical advice of a physician is not available; (2) Finland: the autonomy of the individual municipalities and their responsibility to cover for primary and specialised health care, as well as the EMS, and the lack of supporting or demanding legislation regarding the EMS; (3) Iceland...

  11. Simulation of chloride transport based description soil structure

    International Nuclear Information System (INIS)

    Mahmood-ul-Hassan, M.; Akhtar, M.S.; Gill, S.M.; Nabi, G.

    2003-01-01

    There is a need of environmental implications of rapid appearance of surface by applying chemical at depths below the vadose zone (tile line or shallow groundwater) for developing better insight into solute flow mechanism through the arable lands. Transport of chloride, a representative non-adsorbing solute, through a moderately structured silty clay loam soil (Gujranwala series, Typic Ustochrepts) and an un-structured sandy loam soil (Nabipur series, Typic Camborthid) was characterized and two existing models viz. convection dispersion equation (CDE) and preferential flow models were tested. The flux average of solute concentration in the outflow as a function of cumulative drainage was fitted to the models. The CDE fitted, relatively, better in the non-structured soil than in the moderately structured soil. Dispersivity value determined by CDE was very high for the structured soil which is physically not possible. The preferential flow model fitted well in the Gujranwala soil, but not in the Nabipur soil. The breakthrough characteristics i.e. drainage to peak concentration (Dp), symmetry coefficient (SC), skewness, and kurtosis were compared. Chloride breakthrough was earlier than expected based on piston flow. It indicated preferential flow in both the soils, yet, immediate appearance of the tracer in the Gujranwala soil demonstrated even larger magnitude of the preferential flow. Breakthrough curves' parameters indicated a large amount of the solute movement through the preferred pathways by passing the soil matrix in the Gujranwala soil. The study suggests that some soil structure parameters (size/shape and degree of aggregation) should be incorporated in the solute transport models.(author)

  12. FRF-based structural damage detection of controlled buildings with podium structures: Experimental investigation

    Science.gov (United States)

    Xu, Y. L.; Huang, Q.; Zhan, S.; Su, Z. Q.; Liu, H. J.

    2014-06-01

    How to use control devices to enhance system identification and damage detection in relation to a structure that requires both vibration control and structural health monitoring is an interesting yet practical topic. In this study, the possibility of using the added stiffness provided by control devices and frequency response functions (FRFs) to detect damage in a building complex was explored experimentally. Scale models of a 12-storey main building and a 3-storey podium structure were built to represent a building complex. Given that the connection between the main building and the podium structure is most susceptible to damage, damage to the building complex was experimentally simulated by changing the connection stiffness. To simulate the added stiffness provided by a semi-active friction damper, a steel circular ring was designed and used to add the related stiffness to the building complex. By varying the connection stiffness using an eccentric wheel excitation system and by adding or not adding the circular ring, eight cases were investigated and eight sets of FRFs were measured. The experimental results were used to detect damage (changes in connection stiffness) using a recently proposed FRF-based damage detection method. The experimental results showed that the FRF-based damage detection method could satisfactorily locate and quantify damage.

  13. Tontura em idosos da comunidade: estudo de base populacional Dizziness in community-dewelling older adults: a population-based study

    Directory of Open Access Journals (Sweden)

    Suzana Albuquerque de Moraes

    2011-12-01

    Full Text Available A queixa de tontura é comum em idosos. OBJETIVO: Identificar a prevalência de tontura e os fatores associados em uma amostra de idosos que vivem na comunidade. MATERIAL E MÉTODO: Estudo de coorte histórica prospectivo, com idosos de 65 anos ou mais. Foi utilizado um inquérito multidimensional e uma bateria de testes físico-funcionais. RESULTADOS: A prevalência de tontura foi de 45%. A tontura giratória foi relatada por 70,4% dos idosos e 43,8% disseram já ter tido crises vertiginosas em algum momento da vida. Houve associação significativa entre queixa de tontura e gênero feminino (p=0,004, relato de dificuldade de memória (p=0,015, má percepção de saúde (p=0,001, depressão (pDizziness is a common complaint among older adults. AIM: To identify the prevalence of dizziness and its related factors in a sample of community-dwelling older adults. METHODS: A prospective population-based study with a representative sample of older adults aged 65 years and over. A multidimensional questionnaire and a battery of measures were used for assessing physical function. RESULTS: The prevalence of dizziness was 45%. Vertigo was found in 70.4% of older adults with dizziness and 43.8% of them referred vertigo crises along life. A significant association was found between dizziness and female gender (p=0.004, memory difficulties complaints (p=0.015, bad health perception (p=0.001, depression (p<0.0001, five or more comorbidities (p=0.021, self-reported fatigue (p<0.0001, recurrent falls (p=0.001, excessive sleepiness (p=0.003, fear of falling (p<0.0001, left leg unipedal stance (p=0.002 and Short Performance Physical Battery score (p=0.009. CONCLUSION: Dizziness is a common complaint among older adults and it is associated with limiting clinical conditions, such as depression, fatigue, excessive sleepiness and impaired memory. It is highlighted the association between dizziness and recurrent falls, fear of falling and lower performance in physical

  14. Investimento em Projetos com Base no Planejamento Estratégico: Um Estudo de Caso em uma Fábrica de Carrinhos para Supermercado

    Directory of Open Access Journals (Sweden)

    Osni Hoss

    2013-01-01

    Full Text Available O presente artigo tem por objetivo apresentar um estudo sobre a importância do planejamento e a busca de informações úteis e precisas na hora de investir em projetos, demonstrando a necessidade de alinhar as decisões aos objetivos estratégicos da empresa. Inicialmente, através de uma revisão da literatura acerca do tema abordado, foram apresentados os principais conceitos e definições sobre os critérios de análise de investimentos considerados mais relevantes e sobre planejamento estratégico. A partir disso, através da aplicação dos critérios, buscou-se demonstrar a viabilidade de um investimento para a ampliação das atividades na empresa Zincar Indústria e Comercio de Carrinhos para Supermercado Ltda, localizada na região sudoeste do Paraná, visando oferecer subsídios para a tomada de decisões por parte dos gestores, através do alinhamento das decisões com a estratégia corporativa da empresa.DOI:10.5585/gep.v3i3.113

  15. Determination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplings

    International Nuclear Information System (INIS)

    Montalvao, Rinaldo W.; De Simone, Alfonso; Vendruscolo, Michele

    2012-01-01

    Residual dipolar couplings (RDCs) have the potential of providing detailed information about the conformational fluctuations of proteins. It is very challenging, however, to extract such information because of the complex relationship between RDCs and protein structures. A promising approach to decode this relationship involves structure-based calculations of the alignment tensors of protein conformations. By implementing this strategy to generate structural restraints in molecular dynamics simulations we show that it is possible to extract effectively the information provided by RDCs about the conformational fluctuations in the native states of proteins. The approach that we present can be used in a wide range of alignment media, including Pf1, charged bicelles and gels. The accuracy of the method is demonstrated by the analysis of the Q factors for RDCs not used as restraints in the calculations, which are significantly lower than those corresponding to existing high-resolution structures and structural ensembles, hence showing that we capture effectively the contributions to RDCs from conformational fluctuations.

  16. CARACTERIZAÇÃO MORFOLÓGICA DO DELTA DO RIO DOCE (ES COM BASE EM ANÁLISE MULTISSENSOR

    Directory of Open Access Journals (Sweden)

    Silvia Palotti Polizel

    2014-08-01

    Full Text Available A costa leste brasileira apresenta uma sucessão de sistemas deltaicos, sendo o delta do rio Doce, localizado no Estado do Espírito Santo, um dos mais expressivos. A progradação principal deste delta, de geometria cuspidada típica de deltas de onda, tem sido atribuída à queda do nível do mar que se seguiu à transgressão holocênica média. Análises preliminares de novos produtos de sensoriamento remoto disponibilizados nesses últimos anos mostraram o potencial de aprimoramento do mapa geomorfológico desse delta, que pode contribuir para a melhor reconstituição paleoambiental e evolução desse sistema deposicional. Assim, este trabalho teve por objetivo fornecer um mapa geomorfológico detalhado para a planície costeira do rio Doce com base em dados multissensores integrando Modelo Digital de Elevação (MDE do Shuttle Radar Topography Mission (SRTM, Phased Array type L-band Synthetic Aperture Radar (PALSAR do Advanced Land Observing Satellite (ALOS, imagens TM/Landsat, além de imagens óticas de alta resolução extraídas do Google EarthTM. O mapeamento geomorfológico feito por interpretação visual resultou no estabelecimento de seis classes principais, designadas de: 1 drenagem atual; 2 cordão litorâneo/spit; 3 paleocanal; 4 planície interdistributária; 5 flúvio-estuarino/lagunar/marinho raso; e 6 terraço fluvial. De maneira geral, o emprego combinado dos produtos de sensoriamento produziu resultados satisfatórios para a separação dessas classes. O MDE-SRTM contribuiu para a identificação somente da classe paleocanais. As imagens PALSAR foram úteis na identificação das classes cordão litorâneo/spit, paleocanal, flúvio-estuarino/lagunar/marinho raso e terraço fluvial. As imagens TM/Landsat possibilitaram o reconhecimento das classes drenagem atual, cordão litorâneo/spit, planície interdistributária e flúvio-estuarino/lagunar/marinho raso. O mapa geomorfológico contribuiu na caracterização mais

  17. Structural analysis of paintings based on brush strokes

    Science.gov (United States)

    Sablatnig, Robert; Kammerer, Paul; Zolda, Ernestine

    1998-05-01

    The origin of works of art can often not be attributed to a certain artist. Likewise it is difficult to say whether paintings or drawings are originals or forgeries. In various fields of art new technical methods are used to examine the age, the state of preservation and the origin of the materials used. For the examination of paintings, radiological methods like X-ray and infra-red diagnosis, digital radiography, computer-tomography, etc. and color analyzes are employed to authenticate art. But all these methods do not relate certain characteristics in art work to a specific artist -- the artist's personal style. In order to study this personal style of a painter, experts in art history and image processing try to examine the 'structural signature' based on brush strokes within paintings, in particular in portrait miniatures. A computer-aided classification and recognition system for portrait miniatures is developed, which enables a semi- automatic classification and forgery detection based on content, color, and brush strokes. A hierarchically structured classification scheme is introduced which separates the classification into three different levels of information: color, shape of region, and structure of brush strokes.

  18. MEMS-Based Fuel Reformer with Suspended Membrane Structure

    Science.gov (United States)

    Chang, Kuei-Sung; Tanaka, Shuji; Esashi, Masayoshi

    We report a MEMS-based fuel reformer for supplying hydrogen to micro-fuel cells for portable applications. A combustor and a reforming chamber are fabricated at either side of a suspended membrane structure. This design is used to improve the overall thermal efficiency, which is a critical issue to realize a micro-fuel reformer. The suspended membrane structure design provided good thermal isolation. The micro-heaters consumed 0.97W to maintain the reaction zone of the MEMS-based fuel reformer at 200°C, but further power saving is necessary by improving design and fabrication. The conversion rate of methanol to hydrogen was about 19% at 180°C by using evaporated copper as a reforming catalyst. The catalytic combustion of hydrogen started without any assistance of micro-heaters. By feeding the fuel mixture of an equivalence ratio of 0.35, the temperature of the suspended membrane structure was maintained stable at 100°C with a combustion efficiency of 30%. In future works, we will test a micro-fuel reformer by using a micro-combustor to supply heat.

  19. Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6 and Implications for Ribosome Evolution

    Science.gov (United States)

    Greber, Basil J.; Boehringer, Daniel; Godinic-Mikulcic, Vlatka; Crnkovic, Ana; Ibba, Michael; Weygand-Durasevic, Ivana; Ban, Nenad

    2013-01-01

    Translation of mRNA into proteins by the ribosome is universally conserved in all cellular life. The composition and complexity of the translation machinery differ markedly between the three domains of life. Organisms from the domain Archaea show an intermediate level of complexity, sharing several additional components of the translation machinery with eukaryotes that are absent in bacteria. One of these translation factors is initiation factor 6 (IF6), which associates with the large ribosomal subunit. We have reconstructed the 50S ribosomal subunit from the archaeon Methanothermobacter thermautotrophicus in complex with archaeal IF6 at 6.6 Å resolution using cryo-electron microscopy (EM). The structure provides detailed architectural insights into the 50S ribosomal subunit from a methanogenic archaeon through identification of the rRNA expansion segments and ribosomal proteins that are shared between this archaeal ribosome and eukaryotic ribosomes but are mostly absent in bacteria and in some archaeal lineages. Furthermore, the structure reveals that, in spite of highly divergent evolutionary trajectories of the ribosomal particle and the acquisition of novel functions of IF6 in eukaryotes, the molecular binding of IF6 on the ribosome is conserved between eukaryotes and archaea. The structure also provides a snapshot of the reductive evolution of the archaeal ribosome and offers new insights into the evolution of the translation system in archaea. PMID:22306461

  20. A Novel SMA-based Concept for Airfoil Structural Morphing

    Science.gov (United States)

    Barbarino, S.; Pecora, R.; Lecce, L.; Concilio, A.; Ameduri, S.; Calvi, E.

    2009-08-01

    The adaptive structures concept is of great interest in the aerospace field because of the several benefits which can be accomplished in the fields including noise reduction, load alleviation, weight reduction, etc., at a level in which they can be considered as compulsory in the design of future aircraft. Improvements in terms of the aerodynamic efficiency, aeroelastic behavior, stability, and manoeuvrability performance have already been proved through many international studies in the past. In the family of the Smart Materials, Shape Memory Alloys (SMA) seem to be a suitable solution for many static applications. Their high structural integrability in conjunction with actuation capabilities and a favorable performance per weight ratio, allows the development of original architectures. In this study, a morphing wing trailing edge concept is presented; morphing ability was introduced with the aim of replacing a conventional flap device. A compliant rib structure was designed, based on SMA actuators exhibiting structural potential (bearing external aerodynamic loads). Numerical results, achieved through a FE approach, are presented in terms of trailing edge induced displacement and morphed shape.

  1. Table of periodic properties of fullerenes based on structural parameters.

    Science.gov (United States)

    Torrens, Francisco

    2004-01-01

    The periodic table (PT) of the elements suggests that hydrogen could be the origin of everything else. The construction principle is an evolutionary process that is formally similar to those of Darwin and Oparin. The Kekulé structure count and permanence of the adjacency matrix of fullerenes are related to structural parameters involving the presence of contiguous pentagons p, q and r. Let p be the number of edges common to two pentagons, q the number of vertices common to three pentagons, and r the number of pairs of nonadjacent pentagon edges shared between two other pentagons. Principal component analysis (PCA) of the structural parameters and cluster analysis (CA) of the fullerenes permit classifying them and agree. A PT of the fullerenes is built based on the structural parameters, PCA and CA. The periodic law does not have the rank of the laws of physics. (1) The properties of the fullerenes are not repeated; only, and perhaps, their chemical character. (2) The order relationships are repeated, although with exceptions. The proposed statement is the following: The relationships that any fullerene p has with its neighbor p + 1 are approximately repeated for each period.

  2. Introgression Between Cultivars and Wild Populations of<em> Momordica charantiaem> L. (Cucurbitaceae in Taiwan

    Directory of Open Access Journals (Sweden)

    Yu-Chung Chiang

    2012-05-01

    Full Text Available The landrace strains of <em>Momordica charantia em>are widely cultivated vegetables throughout the tropics and subtropics, but not in Taiwan, a continental island in Southeast Asia, until a few hundred years ago. In contrast, the related wild populations with smaller fruit sizes are native to Taiwan. Because of the introduction of cultivars for agricultural purposes, these two accessions currently exhibit a sympatric or parapatric distribution in Taiwan. In this study, the cultivars<em> em>and wild samples from Taiwan, India, and Korea<em> em>were collected for testing of their hybridization and evolutionary patterns. The cpDNA marker showed a clear distinction between accessions of cultivars and wild populations of Taiwan and a long divergence time. In contrast, an analysis of eight selectively neutral nuclear microsatellite loci did not reveal a difference between the genetic structures of these two accessions. A relatively short divergence time and frequent but asymmetric gene flows were estimated based on the isolation-with-migration model. Historical and current introgression from cultivars to wild populations of Taiwan was also inferred using MIGRATE-n and BayesAss analyses. Our results showed that these two accessions shared abundant common ancestral polymorphisms, and the timing of the divergence and colonization of the Taiwanese wild populations is consistent with the geohistory of the Taiwan Strait land bridge of the Last Glacial Maximum (LGM. Long-term and recurrent introgression between accessions indicated the asymmetric capacity to receive foreign genes from other accessions. The modern introduction of cultivars of <em>M>. <em>charantia> during the colonization of Taiwan by the Han Chinese ethnic group enhanced the rate of gene replacement in the native populations and resulted in the loss of native genes.

  3. Parasitic zoonoses: survey in foxes (<em>Vulpes vulpesem> in the northern Apennines / Zoonosi parassitarie: indagini in volpi (<em>Vulpes vulpesem> dell'Appennino settentrionale

    Directory of Open Access Journals (Sweden)

    Vittorio Guberti

    1991-07-01

    Full Text Available Abstract A parasitological survey on 153 foxes was carried out in the northern Apennines, during the period 1984-1987. The following parasites were identified: <em>Toxocara canisem> (46.4%, <em>Taenia> sp. (17%, <em>Uncinaria stenocephalaem> (11.8%, <em>Mesocestoides lineatusem> (11.1%, <em>Ancylostoma caninumem> (3.9%, <em>Taenia hydatigenaem> (3.3%, <em>Trichuris vulpisem> (3.3%, <em>Dipylidium caninumem> (2.6%, <em>Taenia crassicepsem> (2%. All foxes were negative for <em>Trichinella> sp. A statistical analysis was performed to evaluate differences in the parasitic fauna according to the sex and age classes of the hosts. The role that the fox could have as a reservoir of helminthic zoonoses is discussed. The results are compared with those of similar studies carried out in Italy. Riassunto Nel periodo 1984-1987 è stata condotta un'indagine parassitologica su 153 volpi abbattute nell'Appennino romagnolo. Sono stati reperiti i seguenti parassiti: <em>Toxocara canisem> (46,4%, <em>Taenia> sp. (17%, <em>Uncinaria stenocephalaem> (11,8%, <em>Mesocestoides lineatusem> (11,1%, <em>Ancylostoma caninumem> (3,9%, <em>Taenia hydatigenaem> (3,3%, <em>Trichuris vulpisem> (3,3%, <em>Dipylidium caninumem> (2,6%, <em>Taenia crassicepsem> (2%. Tutte le volpi esaminate sono risultate negative per <em>Trichinella> sp. È stata effettuata l'analisi statistica dei dati per evidenziare eventuali differenze della fauna parassitaria in relazione al sesso e all'età delle volpi. Sulla base dei dati ottenuti viene discussa l'importanza che la Volpe può assumere come serbatoio di zoonosi elmintiche. I risultati acquisiti sono inoltre comparati con quelli ottenuti in analoghe ricerche condotte in Italia.

  4. Structural level characterization of base oils using advanced analytical techniques

    KAUST Repository

    Hourani, Nadim

    2015-05-21

    Base oils, blended for finished lubricant formulations, are classified by the American Petroleum Institute into five groups, viz., groups I-V. Groups I-III consist of petroleum based hydrocarbons whereas groups IV and V are made of synthetic polymers. In the present study, five base oil samples belonging to groups I and III were extensively characterized using high performance liquid chromatography (HPLC), comprehensive two-dimensional gas chromatography (GC×GC), and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) equipped with atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI) sources. First, the capabilities and limitations of each analytical technique were evaluated, and then the availed information was combined to reveal compositional details on the base oil samples studied. HPLC showed the overwhelming presence of saturated over aromatic compounds in all five base oils. A similar trend was further corroborated using GC×GC, which yielded semiquantitative information on the compound classes present in the samples and provided further details on the carbon number distributions within these classes. In addition to chromatography methods, FT-ICR MS supplemented the compositional information on the base oil samples by resolving the aromatics compounds into alkyl- and naphtheno-subtituted families. APCI proved more effective for the ionization of the highly saturated base oil components compared to APPI. Furthermore, for the detailed information on hydrocarbon molecules FT-ICR MS revealed the presence of saturated and aromatic sulfur species in all base oil samples. The results presented herein offer a unique perspective into the detailed molecular structure of base oils typically used to formulate lubricants. © 2015 American Chemical Society.

  5. Gigascale Silicon Photonic Transmitters Integrating HBT-based Carrier-injection Electroabsorption Modulator Structures

    Science.gov (United States)

    Fu, Enjin

    injection modulators and light-emitting diodes (LED) with drive voltage requirements below 1.5V. Measurement results show an optical link based on a 70MHz red LED work well at 300Mbps by using the pre-emphasis driver module. A traveling wave electrode (TWE) modulator structure is presented, including a novel design methodology to address process limitations imposed by a commercial silicon fabrication technology. Results from 3D full wave EM simulation demonstrate the application of the design methodology to achieve specifications, including phase velocity matching, insertion loss, and impedance matching. Results show the HBT-based TWE-EAM system has the bandwidth higher than 60GHz.

  6. Support system of a structure on a support base

    International Nuclear Information System (INIS)

    Arene, G.; Renaux, C.; Minguet, J.L.; Chantot, H.

    1984-01-01

    Two series of strips are fixed to the structure to be supported and to the base to define each one a closed convex envelope; the strips are flexible in the radial direction with regard to the envelope. The two series of strips are connected by a treillis of rigid bars set to form juxtaposed V or X. A good transversal rigidity and a certain radial flexibility are obtained. The invention can be applied to a fast neutron nuclear reactor, the reactor comprising a vertical axis vessel filled with liquid metal; the vessel rests on a support foundation by means of the support system proposed by the invention. The support system allows the supported structure to resist the effects of an eventual earthquake and brutal temperature variations [fr

  7. Ultrafast Dynamic Pressure Sensors Based on Graphene Hybrid Structure.

    Science.gov (United States)

    Liu, Shanbiao; Wu, Xing; Zhang, Dongdong; Guo, Congwei; Wang, Peng; Hu, Weida; Li, Xinming; Zhou, Xiaofeng; Xu, Hejun; Luo, Chen; Zhang, Jian; Chu, Junhao

    2017-07-19

    Mechanical flexible electronic skin has been focused on sensing various physical parameters, such as pressure and temperature. The studies of material design and array-accessible devices are the building blocks of strain sensors for subtle pressure sensing. Here, we report a new and facile preparation of a graphene hybrid structure with an ultrafast dynamic pressure response. Graphene oxide nanosheets are used as a surfactant to prevent graphene restacking in aqueous solution. This graphene hybrid structure exhibits a frequency-independent pressure resistive sensing property. Exceeding natural skin, such pressure sensors, can provide transient responses from static up to 10 000 Hz dynamic frequencies. Integrated by the controlling system, the array-accessible sensors can manipulate a robot arm and self-rectify the temperature of a heating blanket. This may pave a path toward the future application of graphene-based wearable electronics.

  8. Edge detection based on computational ghost imaging with structured illuminations

    Science.gov (United States)

    Yuan, Sheng; Xiang, Dong; Liu, Xuemei; Zhou, Xin; Bing, Pibin

    2018-03-01

    Edge detection is one of the most important tools to recognize the features of an object. In this paper, we propose an optical edge detection method based on computational ghost imaging (CGI) with structured illuminations which are generated by an interference system. The structured intensity patterns are designed to make the edge of an object be directly imaged from detected data in CGI. This edge detection method can extract the boundaries for both binary and grayscale objects in any direction at one time. We also numerically test the influence of distance deviations in the interference system on edge extraction, i.e., the tolerance of the optical edge detection system to distance deviation. Hopefully, it may provide a guideline for scholars to build an experimental system.

  9. Structure-based control of complex networks with nonlinear dynamics.

    Science.gov (United States)

    Zañudo, Jorge Gomez Tejeda; Yang, Gang; Albert, Réka

    2017-07-11

    What can we learn about controlling a system solely from its underlying network structure? Here we adapt a recently developed framework for control of networks governed by a broad class of nonlinear dynamics that includes the major dynamic models of biological, technological, and social processes. This feedback-based framework provides realizable node overrides that steer a system toward any of its natural long-term dynamic behaviors, regardless of the specific functional forms and system parameters. We use this framework on several real networks, identify the topological characteristics that underlie the predicted node overrides, and compare its predictions to those of structural controllability in control theory. Finally, we demonstrate this framework's applicability in dynamic models of gene regulatory networks and identify nodes whose override is necessary for control in the general case but not in specific model instances.

  10. Ultrafast protein structure-based virtual screening with Panther

    Science.gov (United States)

    Niinivehmas, Sanna P.; Salokas, Kari; Lätti, Sakari; Raunio, Hannu; Pentikäinen, Olli T.

    2015-10-01

    Molecular docking is by far the most common method used in protein structure-based virtual screening. This paper presents Panther, a novel ultrafast multipurpose docking tool. In Panther, a simple shape-electrostatic model of the ligand-binding area of the protein is created by utilizing the protein crystal structure. The features of the possible ligands are then compared to the model by using a similarity search algorithm. On average, one ligand can be processed in a few minutes by using classical docking methods, whereas using Panther processing takes Panther protocol can be used in several applications, such as speeding up the early phases of drug discovery projects, reducing the number of failures in the clinical phase of the drug development process, and estimating the environmental toxicity of chemicals. Panther-code is available in our web pages (http://www.jyu.fi/panther) free of charge after registration.

  11. Radiography simulation based on exposure buildup factors for multilayer structures

    International Nuclear Information System (INIS)

    Marinkovic, Predrag; Pesic, Milan

    2009-01-01

    Monte Carlo techniques were usually used to study the effect of scattered photons on a radiographic X-ray image. Such approach is accurate, but computer time consuming. On the other hand, the exposure buildup factors can be used as approximate and efficient assessment to account for the scattering of X-rays. This method uses the known radiography parameters to find the resulting detector exposure due to both scattered and un-collided photons. A model for radiography simulation, based on X-ray dose buildup factor, is proposed. This model includes non-uniform attenuation in voxelized object of imaging (patient body tissue). Composition of patient body is considered as a multi-layer structure. Various empirical formulas exist for multi-layer structure calculations and they all calculate multi-layer buildup factors by combining single-layer buildup factors. The proposed model is convenient in cases when more exact techniques (like Monte Carlo) are not economical. (author)

  12. Interactive Reliability-Based Optimization of Structural Systems

    DEFF Research Database (Denmark)

    Pedersen, Claus

    In order to introduce the basic concepts within the field of reliability-based structural optimization problems, this chapter is devoted to a brief outline of the basic theories. Therefore, this chapter is of a more formal nature and used as a basis for the remaining parts of the thesis. In section...... 2.2 a general non-linear optimization problem and corresponding terminology are presented whereupon optimality conditions and the standard form of an iterative optimization algorithm are outlined. Subsequently, the special properties and characteristics concerning structural optimization problems...... are treated in section 2.3. With respect to the reliability evalutation, the basic theory behind a reliability analysis and estimation of probability of failure by the First-Order Reliability Method (FORM) and the iterative Rackwitz-Fiessler (RF) algorithm are considered in section 2.5 in which...

  13. Infrared Fibers for Use in Space-Based Smart Structures

    Science.gov (United States)

    Tucker, Dennis S.; Nettles, Alan T.; Brantley, Lott W. (Technical Monitor)

    2001-01-01

    Infrared optical fibers are finding a number of applications including laser surgery, remote sensing, and nuclear radiation resistant links. Utilizing these fibers in space-based structures is another application, which can be exploited. Acoustic and thermal sensing are two areas in which these fibers could be utilized. In particular, fibers could be embedded in IM7/8552 toughened epoxy and incorporated into space structures both external and internal. ZBLAN optical fibers are a candidate, which have been studied extensively over the past 20 years for terrestrial applications. For the past seven years the effects of gravity on the crystallization behavior of ZBLAN optical fiber has been studied. It has been found that ZBLAN crystallization is suppressed in microgravity. This lack of crystallization leads to a fiber with better transmission characteristics than its terrestrial counterpart.

  14. Intervenção educacional com base em modelo para aumentar a atividade física entre adolescentes iranianos

    Directory of Open Access Journals (Sweden)

    Hormoz Sanaeinasab

    2012-10-01

    Full Text Available OBJETIVO: Avaliar um programa educacional com base no modelo de promoção da saúde (MPS e nos estágios de mudança para melhorar a atividade física (AF entre adolescentes iranianos. MÉTODOS: Este foi um ensaio randomizado controlado com 165 participantes divididos em dois grupos (intervenção/controle. Os dados foram coletados através de questionários de autopreenchimento com base em componentes do MPS (benefícios e barreiras para a ação, autoeficácia, sentimentos em relação ao comportamento, influências interpessoais e situacionais. A escala de estágios de mudança foi utilizada para selecionar participantes aptos (classificados nos estágios de pré-contemplação, contemplação ou preparação e para avaliar a tendência. Após a coleta dos dados de base, a intervenção foi realizada nos participantes e os dados de acompanhamento foram coletados 3 meses depois. RESULTADOS: Ao todo, 88 meninos e 77 meninas com idade média de 13,99±0,4 participaram do estudo. As diferenças em todos os componentes do MPS, exceto os sentimentos em relação ao comportamento e as influências sociais, foram significantes (p < 0,01 entre os valores de base e de acompanhamento. Comparados aos do grupo de controle, os adolescentes do grupo de intervenção foram categorizados nos estágios de ação (70% ou preparação (30% no acompanhamento. A análise de regressão múltipla revelou que preferências concorrentes, normas sociais, modelos sociais (variáveis com p < 0,001 e o compromisso com o plano de ação podem prever consideravelmente o comportamento quanto à AF. O modelo representou 22,5% da variação da AF. CONCLUSÕES: Intervenções educacionais com base nos estágios de mudança podem ter implicações importantes na melhora da AF entre adolescentes em mais componentes do MPS.

  15. Pulsed EM Field Response of a Thin, High-Contrast, Finely Layered Structure With Dielectric and Conductive Properties

    NARCIS (Netherlands)

    De Hoop, A.T.; Jiang, L.

    2009-01-01

    The response of a thin, high-contrast, finely layered structure with dielectric and conductive properties to an incident, pulsed, electromagnetic field is investigated theoretically. The fine layering causes the standard spatial discretization techniques to solve Maxwell's equations numerically to

  16. Seismic assessment of reinforced concrete frame structures with a new flexibility based element

    Science.gov (United States)

    Arede, Antonio Jose Coelho Dias

    diopsidio contendo Al na estrutura, sinterizacao e no comportamento durante a cristalizacao de vidros e nas propriedades dos materiais vitro-cerâmicos, com relevância para a sua aplicacao como selantes em SOFC. Verificou-se que Foi observado que os vidros/vitro-cerâmicos a base de enstatite nao apresentavam as caracteristicas necessarias para serem usados como materiais selantes em SOFC, enquanto as melhores propriedades apresentadas pelos vitro-cerâmicos a base de diopsidio qualificaram-nos para futuros estudos neste tipo de aplicacoes. Para alem de investigar a adequacao dos vitro-cerâmicos a base de clinopyroxene como selantes, esta tese tem tambem como objetivo estudar a influencia dos agentes de nucleacao na nucleacao em volume dos vitro-cerâmicos resultantes a base de diopsidio, de modo a qualifica-los como potenciais materiais hopedeiros de residuos nucleares radioactivos.

  17. O que é emoção? em busca da organização estrutural do conceito de emoção em crianças What is emotion? searching the organizational structure of children's concept of emotion

    Directory of Open Access Journals (Sweden)

    Antonio Roazzi

    2011-01-01

    tipo modular.The main aim of this study was to investigate the structural organization of the semantic concept of emotion in children based on an emic perspective. A free word association (emotion and two questions (frequency of emotions and what they knew about emotions was applied to a sample of 247 children aged 7-12 from public and private schools in Brazil. The question concerning what they knew about emotions indicated that most children link emotions to feelings, things their heart feels. Participants also gave examples of positive and negative experiences, specifying certain emotions, mainly emotions classified as primary by researchers in this field. Regarding the question about the frequency of those emotions in their lives, they pointed out joy, happiness and sadness as being the emotions frequently experienced on their daily lives. On the free word association primary emotions predominated being joy the most frequent one, followed by sadness, happiness, anger, fear and love. We also encountered more elaborate emotions (secondary emotions such as missing someone, hatred, peace, and anxiety, among others. In order to verify the structural organization of their semantic conceptual field, we analyzed the categories that participants emitted on the free association task by means of Structural Similarity Analysis (SSA. A method of "external variables as points" was applied with the intention of verifying the relation between the structure created from the semantic field and the variables of age, sex and type of school. Multiple regressions were also computed. It was found that the type of school and, especially, age played a relevant role in predicting the structural organization of emotions, i.e. an ordered modular structure.

  18. Structure-based, rational design of T cell receptors

    Directory of Open Access Journals (Sweden)

    Vincent eZoete

    2013-09-01

    Full Text Available Adoptive cell transfer using engineered T cells is emerging as a promising treatment for metastatic melanoma. Such an approach allows one to introduce TCR modifications that, while maintaining the specificity for the targeted antigen, can enhance the binding and kinetic parameters for the interaction pMHC. Using the well-characterized 2C TCR/SIYR/H-2K(b structure as a model system, we demonstrated that a binding free energy decomposition based on the MM-GBSA approach provides a detailed and reliable description of the TCR/pMHC interactions at the structural and thermodynamic levels. Starting from this result, we developed a new structure-based approach, to rationally design new TCR sequences, and applied it to the BC1 TCR targeting the HLA-A2 restricted NY-ESO-1157-165 cancer-testis epitope. 54% of the designed sequence replacements exhibited improved pMHC-binding as compared to the native TCR, with up to 150 fold increase in affinity, while preserving specificity. Genetically-engineered CD8+ T cells expressing these modified TCRs showed an improved functional activity compared to those expressing BC1 TCR. We measured maximum levels of activities for TCRs within the upper limit of natural affinity. Beyond the affinity threshold at KD < 1 μM we observed an attenuation in cellular function. We have also developed a homology modeling-based approach, TCRep 3D, to obtain accurate structural models of any TCR-pMHC complexes. We have complemented the approach with a simplified rigid method to predict the TCR orientation over pMHC. These methods potentially extend the use of our TCR engineering method to entire TCR repertoires for which no X-ray structure is available. We have also performed a steered molecular dynamics study of the unbinding of the TCR-pMHC complex to get a better understanding of how TCRs interact with pMHCs. This entire rational TCR design pipeline is now being used to produce rationally optimized TCRs for adoptive cell therapies of

  19. Principal Component Analysis Based Measure of Structural Holes

    Science.gov (United States)

    Deng, Shiguo; Zhang, Wenqing; Yang, Huijie

    2013-02-01

    Based upon principal component analysis, a new measure called compressibility coefficient is proposed to evaluate structural holes in networks. This measure incorporates a new effect from identical patterns in networks. It is found that compressibility coefficient for Watts-Strogatz small-world networks increases monotonically with the rewiring probability and saturates to that for the corresponding shuffled networks. While compressibility coefficient for extended Barabasi-Albert scale-free networks decreases monotonically with the preferential effect and is significantly large compared with that for corresponding shuffled networks. This measure is helpful in diverse research fields to evaluate global efficiency of networks.

  20. Localization-based super-resolution imaging of cellular structures.

    Science.gov (United States)

    Kanchanawong, Pakorn; Waterman, Clare M

    2013-01-01

    Fluorescence microscopy allows direct visualization of fluorescently tagged proteins within cells. However, the spatial resolution of conventional fluorescence microscopes is limited by diffraction to ~250 nm, prompting the development of super-resolution microscopy which offers resolution approaching the scale of single proteins, i.e., ~20 nm. Here, we describe protocols for single molecule localization-based super-resolution imaging, using focal adhesion proteins as an example and employing either photoswitchable fluorophores or photoactivatable fluorescent proteins. These protocols should also be easily adaptable to imaging a broad array of macromolecular assemblies in cells whose components can be fluorescently tagged and assemble into high density structures.

  1. Reliability-Based Inspection Planning for Structural Systems

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard

    1993-01-01

    A general model for reliability-based optimal inspection and repair strategies for structural systems is described. The total expected costs in the design lifetime is minimized with the number of inspections, the inspection times and efforts as decision variables. The equivalence of this model...... with a preposterior analysis from statistical decision theory is discussed. It is described how information obtained by an inspection can be used in a repair decision. Stochastic models for inspection, measurement and repair actions are presented. The general model is applied for inspection and repair planning...

  2. Estrutura do capim-braquiária em relação à planta daninha = Structure of signalgrass in relation to weeds

    Directory of Open Access Journals (Sweden)

    Manoel Eduardo Rozalino Santos

    2011-07-01

    Full Text Available O objetivo foi avaliar as características estruturais da Brachiaria decumbens cv. Basilisk em relação à planta daninha Solanum sisymbrifolium no pasto. Os tratamentos foram dois locais no mesmo pasto, quais sejam, próximo e distante da planta daninha. O delineamento foi em blocos ao acaso com três repetições. O pasto foi manejado sob lotação contínua, com bovinos e com altura média de aproximadamente 25 cm. Foram quantificadas as densidades populacionais das categorias de tamanho dos perfilhos, a altura, a interceptação de luz, as massas e as densidades volumétricas dos componentes morfológicos do pasto. No local distante da planta daninha houve maior ocorrência de perfilhos com tamanho inferior a 20 cm. Já no local próximo da planta daninha, predominaram perfilhos com tamanho superior a 40 cm. A presença da planta daninha ocasionou aumento na altura do pasto e incremento na interceptação de luz pelo dossel. As massas e as densidades volumétricas de lâmina foliar viva, colmo vivo e material morto foram inferiores no local próximo da planta daninha em relação ao local distante. A ocorrência da planta S. sisymbrifolium provoca variabilidade espacial da vegetação no pasto de B. decumbens manejado sob lotação contínua com bovinos.The objective of this study was to evaluate the structural characteristics of Brachiaria decumbens cv. Basilisk in relation toSolanum sisymbrifolium in pasture. The treatments were two sites in the same pasture, near and far from the weeds. A randomized block design with three replications was used. The pasture was managed under continuous stocking and grass height was kept at about 25cm.Densities were quantified for categories tiller size, height, light interception, masses and volumetric densities of morphological components of the pasture. In the site far from the weeds there is a higher occurrence of tillers with size smaller than 20 cm. In site near the weeds, tillers larger than 40 cm

  3. Investigation on removal of malachite green using EM based compost as adsorbent.

    Science.gov (United States)

    Bhagavathi Pushpa, T; Vijayaraghavan, J; Sardhar Basha, S J; Sekaran, V; Vijayaraghavan, K; Jegan, J

    2015-08-01

    The discarded materials from different sources can be utilized as effective materials in wastewater remediation. This proposed study was aimed mainly to investigate the possibility of Effective Microorganisms based compost (EMKC), which is derived from the kitchen solid waste, as a non-conventional low cost adsorbent for the removal of malachite green from aqueous solution. Batch experiments were carried out to evaluate the optimum operating parameters like pH (2-9), initial dye concentration (50-1000mg/L), adsorbent particle size (0.6-2.36mm) and adsorbent dosage (2-12g/L). EMKC recorded maximum uptake of 136.6mg/g of MG at pH 8, initial dye concentration 1000mg/L, adsorbent particle size 1.18mm and adsorbent dosage 4g/L. Two and three parameter adsorption models were employed to describe experimental biosorption isotherm data. The results revealed that the Sips model resulted in better fit than other models. The pseudo-first and -second order models were applied to describe kinetic data, of which the pseudo-second order described experimental data better with high correlation coefficient. This investigation suggested that EMKC could be an effective and low cost material for the removal of malachite green dye from aqueous solution. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Precision of EM Simulation Based Wireless Location Estimation in Multi-Sensor Capsule Endoscopy.

    Science.gov (United States)

    Khan, Umair; Ye, Yunxing; Aisha, Ain-Ul; Swar, Pranay; Pahlavan, Kaveh

    2018-01-01

    In this paper, we compute and examine two-way localization limits for an RF endoscopy pill as it passes through an individuals gastrointestinal (GI) tract. We obtain finite-difference time-domain and finite element method-based simulation results position assessment employing time of arrival (TOA). By means of a 3-D human body representation from a full-wave simulation software and lognormal models for TOA propagation from implant organs to body surface, we calculate bounds on location estimators in three digestive organs: stomach, small intestine, and large intestine. We present an investigation of the causes influencing localization precision, consisting of a range of organ properties; peripheral sensor array arrangements, number of pills in cooperation, and the random variations in transmit power of sensor nodes. We also perform a localization precision investigation for the situation where the transmission signal of the antenna is arbitrary with a known probability distribution. The computational solver outcome shows that the number of receiver antennas on the exterior of the body has higher impact on the precision of the location than the amount of capsules in collaboration within the GI region. The large intestine is influenced the most by the transmitter power probability distribution.

  5. Estudo de argamassa à base de cal e metacaulim para intervenções em revestimento das edificações históricas

    OpenAIRE

    Souza, Juliana Santa Cruz

    2013-01-01

    O objetivo deste trabalho é caracterizar argamassas a base de cal com teores diferenciados de metacaulim para a restauração de revestimento nas edificações históricas. Confrontou-se cinco traços de argamassa à base de cal, metacaulim e mistura binária de agregado miúdo, sendo mantida a proporção de ligante e agregado em massa constante 1:3. Os traços possuem modificação na proporção de cal e metacaulim, sendo a cal substituída em massa por metacaulim nas porcentagens de 0%, ...

  6. Agricultura orgânica em áreas urbanas e periurbanas com base na agroecologia Challenges of organic agriculture in urban and suburban areas

    Directory of Open Access Journals (Sweden)

    Adriana Maria de Aquino

    2007-06-01

    Full Text Available A agricultura orgânica com base na agroecologia é o mote tecnológico adequado à realidade dos agroecossistemas urbanos. Este artigo ressalta a necessidade de se desenvolver tecnologias e insumos específicos. A partir de experiências com agricultura urbana em diferentes países em desenvolvimento, evidencia-se a necessidade de se buscar capacidades locais e apoio do poder público, especialmente nas iniciativas da sociedade organizada e mobilizada para a produção agrícola urbana.This article presents organic agriculture, based on agroecology, as the appropriate technology for the urban agro-ecosystem. It also points out the need for appropriate technologies and amendments development. Looking at experiences with urban agriculture in development countries, it shows the need for local capacity development and a search for the public sector support, specially of organized groups mobilized for urban agriculture production.

  7. Estimativa do escoamento superficial em uma bacia hidrográfica com base em modelagem dinâmica e distribuída Surface runoff in a watershed estimated by dynamic and distributed modeling

    Directory of Open Access Journals (Sweden)

    Samuel Beskow

    2009-02-01

    Full Text Available A estimativa do escoamento superficial em bacias hidrográficas é de suma importância para conservação dos recursos naturais; entretanto, esse é um processo complexo e dinâmico, principalmente no contexto de sua variabilidade espacial. Dessa forma, torna-se adequada a aplicação dos Sistemas de Informações Geográficas (SIG usando pequenas células de informação, pois assim é possível considerar o comportamento espacial das variáveis associadas à origem do escoamento superficial. Este trabalho teve como objetivo implementar os modelos hidrológicos Curva Número (CN-SCS e Curva-Número Modificado (CN-MMS, com base na linguagem de programação do SIG PCRaster e em uma base de dados reduzida, de forma distribuída e dinâmica, com o intuito de estimar as lâminas de escoamento superficial geradas numa bacia hidrográfica de Latossolos, localizada no município de Nazareno, região dos Campos das Vertentes, Minas Gerais. Para aplicação do modelo CN-SCS foi preciso desenvolver um mapa com valores de CN no formato do PCRaster, enquanto para o modelo CN-MMS foram necessários os seguintes mapas: umidade volumétrica de saturação do solo, umidade volumétrica inicial do solo e profundidade de solo. Para simulação e avaliação de ambos os modelos, foram aplicados 18 eventos de chuva natural que provocaram escoamento superficial, durante o ano hidrológico 2004-2005, e suas respectivas lâminas de escoamento observadas. A análise do desempenho dos modelos foi feita aplicando-se análise de sensibilidade baseada no erro médio e na Raiz do Erro Quadrático (REQ. Tendo-se como referência essas estatísticas de precisão, pôde-se constatar que o modelo CN-MMS apresentou melhor calibração quando comparado ao modelo CN-SCS, devido à consideração direta da umidade inicial do solo. Contudo, a estruturação dos modelos no SIG PCRaster possibilitou o desenvolvimento de uma ferramenta computacional eficaz e útil para simulação do

  8. Estrutura fatorial da Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES em dependentes de álcool tratados ambulatorialmente Factor structure of the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES in alcohol dependent outpatients

    Directory of Open Access Journals (Sweden)

    Neliana Buzi Figlie

    2004-06-01

    Full Text Available OBJETIVO: O objetivo deste estudo foi o de investigar a confiabilidade e a estrutura fatorial da Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES, versão 8,¹ instrumento com 19 itens que mensura a prontidão para a mudança em dependentes de álcool. MÉTODOS: Uma análise fatorial confirmatória da SOCRATES foi realizada em uma amostra de 326 dependentes de álcool, tratados ambulatorialmente, tendo como base a estrutura fatorial demonstrada por Miller & Tonigan² e Maisto et al.³ O questionário foi traduzido e adaptado culturalmente para o idioma português, sendo posteriormente submetido ao procedimento da retradução para o idioma inglês. Durante esse procedimento, foram realizadas algumas modificações, visando a simplificar alguns itens que apresentaram formato complexo. RESULTADOS: As análises estatísticas mostraram a existência de dois fatores correlacionados que melhor exploraram o modelo, sendo este achado similar ao estudo de Maisto et al.³ CONCLUSÕES: Foi constatada menor evidência para o modelo de três fatores. Esses resultados são comparados com estudos prévios e as discrepâncias são discutidas neste artigo.OBJECTIVE: The aim of this study was to investigate the reliability and factor structure of the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES, version 8,¹ a 19-item self-reported instrument developed to measure readiness to change in alcohol-dependent alcoholics. METHODS: A Confirmatory Factor analysis of the SOCRATES was performed based on the factor structures previously demonstrated by Miller & Tonigan² and Maisto et al.³ in a sample with 326 alcohol-dependent outpatients. The questionnaire was translated into Portuguese, cross-culturally adapted and back-translated into English. During this process SOCRATES underwent some modifications to simplify some complex question formats. RESULTS: The analysis showed that two correlated factors provided the best fit for the

  9. EWET: Data collection and interface for the genetic analysis of Echinococcus multilocularis based on EmsB microsatellite

    Science.gov (United States)

    Damy, Sylvie; Brillaud, Jonathan; Tissot, Jean-Daniel; Navion, Jérémy; Mélior, Raphael; Afonso, Eve; Hormaz, Vanessa; Gottstein, Bruno; Umhang, Gérald; Casulli, Adriano; Dadeau, Frédéric; Millon, Laurence; Raoul, Francis

    2017-01-01

    Evolution and dispersion history on Earth of organisms can best be studied through biological markers in molecular epidemiological studies. The biological diversity of the cestode Echinococcus multilocularis was investigated in different cladistic approaches. First the morphological aspects were explored in connection with its ecology. More recently, molecular aspects were investigated to better understand the nature of the variations observed among isolates. The study of the tandemly repeated multilocus microsatellite EmsB allowed us to attain a high genetic diversity level where other classic markers have failed. Since 2006, EmsB data have been collected on specimens from various endemic foci of the parasite in Europe (in historic and newly endemic areas), Asia (China, Japan and Kyrgyzstan), and North America (Canada and Alaska). Biological data on the isolates and metadata were also recorded (e.g. host, geographical location, EmsB analysis, citation in the literature). In order to make available the data set of 1,166 isolates from classic and aberrant domestic and wild animal hosts (larval lesions and adult worms) and from human origin, an open web access interface, developed in PHP, and connected to a PostgreSQL database, was developed in the EmsB Website for the Echinococcus Typing (EWET) project. It allows researchers to access data collection, perform genetic analyses online (e.g. defining the genetic distance between their own samples and the samples in the database), consult distribution maps of EmsB profiles, and record and share their new EmsB genotyping data. In order to standardize the EmsB analyses performed in the different laboratories throughout the world, a calibrator was developed. The final aim of this project was to gather and arrange available data to permit to better understand the dispersion and transmission patterns of the parasite among definitive and intermediate hosts, in order to organize control strategies on the ground. PMID:28972978

  10. EWET: Data collection and interface for the genetic analysis of Echinococcus multilocularis based on EmsB microsatellite.

    Science.gov (United States)

    Knapp, Jenny; Damy, Sylvie; Brillaud, Jonathan; Tissot, Jean-Daniel; Navion, Jérémy; Mélior, Raphael; Afonso, Eve; Hormaz, Vanessa; Gottstein, Bruno; Umhang, Gérald; Casulli, Adriano; Dadeau, Frédéric; Millon, Laurence; Raoul, Francis

    2017-01-01

    Evolution and dispersion history on Earth of organisms can best be studied through biological markers in molecular epidemiological studies. The biological diversity of the cestode Echinococcus multilocularis was investigated in different cladistic approaches. First the morphological aspects were explored in connection with its ecology. More recently, molecular aspects were investigated to better understand the nature of the variations observed among isolates. The study of the tandemly repeated multilocus microsatellite EmsB allowed us to attain a high genetic diversity level where other classic markers have failed. Since 2006, EmsB data have been collected on specimens from various endemic foci of the parasite in Europe (in historic and newly endemic areas), Asia (China, Japan and Kyrgyzstan), and North America (Canada and Alaska). Biological data on the isolates and metadata were also recorded (e.g. host, geographical location, EmsB analysis, citation in the literature). In order to make available the data set of 1,166 isolates from classic and aberrant domestic and wild animal hosts (larval lesions and adult worms) and from human origin, an open web access interface, developed in PHP, and connected to a PostgreSQL database, was developed in the EmsB Website for the Echinococcus Typing (EWET) project. It allows researchers to access data collection, perform genetic analyses online (e.g. defining the genetic distance between their own samples and the samples in the database), consult distribution maps of EmsB profiles, and record and share their new EmsB genotyping data. In order to standardize the EmsB analyses performed in the different laboratories throughout the world, a calibrator was developed. The final aim of this project was to gather and arrange available data to permit to better understand the dispersion and transmission patterns of the parasite among definitive and intermediate hosts, in order to organize control strategies on the ground.

  11. EWET: Data collection and interface for the genetic analysis of Echinococcus multilocularis based on EmsB microsatellite.

    Directory of Open Access Journals (Sweden)

    Jenny Knapp

    Full Text Available Evolution and dispersion history on Earth of organisms can best be studied through biological markers in molecular epidemiological studies. The biological diversity of the cestode Echinococcus multilocularis was investigated in different cladistic approaches. First the morphological aspects were explored in connection with its ecology. More recently, molecular aspects were investigated to better understand the nature of the variations observed among isolates. The study of the tandemly repeated multilocus microsatellite EmsB allowed us to attain a high genetic diversity level where other classic markers have failed. Since 2006, EmsB data have been collected on specimens from various endemic foci of the parasite in Europe (in historic and newly endemic areas, Asia (China, Japan and Kyrgyzstan, and North America (Canada and Alaska. Biological data on the isolates and metadata were also recorded (e.g. host, geographical location, EmsB analysis, citation in the literature. In order to make available the data set of 1,166 isolates from classic and aberrant domestic and wild animal hosts (larval lesions and adult worms and from human origin, an open web access interface, developed in PHP, and connected to a PostgreSQL database, was developed in the EmsB Website for the Echinococcus Typing (EWET project. It allows researchers to access data collection, perform genetic analyses online (e.g. defining the genetic distance between their own samples and the samples in the database, consult distribution maps of EmsB profiles, and record and share their new EmsB genotyping data. In order to standardize the EmsB analyses performed in the different laboratories throughout the world, a calibrator was developed. The final aim of this project was to gather and arrange available data to permit to better understand the dispersion and transmission patterns of the parasite among definitive and intermediate hosts, in order to organize control strategies on the ground.

  12. Density-based and transport-based core-periphery structures in networks.

    Science.gov (United States)

    Lee, Sang Hoon; Cucuringu, Mihai; Porter, Mason A

    2014-03-01

    Networks often possess mesoscale structures, and studying them can yield insights into both structure and function. It is most common to study community structure, but numerous other types of mesoscale structures also exist. In this paper, we examine core-periphery structures based on both density and transport. In such structures, core network components are well-connected both among themselves and to peripheral components, which are not well-connected to anything. We examine core-periphery structures in a wide range of examples of transportation, social, and financial networks-including road networks in large urban areas, a rabbit warren, a dolphin social network, a European interbank network, and a migration network between counties in the United States. We illustrate that a recently developed transport-based notion of node coreness is very useful for characterizing transportation networks. We also generalize this notion to examine core versus peripheral edges, and we show that the resulting diagnostic is also useful for transportation networks. To examine the properties of transportation networks further, we develop a family of generative models of roadlike networks. We illustrate the effect of the dimensionality of the embedding space on transportation networks, and we demonstrate that the correlations between different measures of coreness can be very different for different types of networks.

  13. Guided wave based structural health monitoring: A review

    International Nuclear Information System (INIS)

    Mitra, Mira; Gopalakrishnan, S

    2016-01-01

    The paper provides a state of the art review of guided wave based structural health monitoring (SHM). First, the fundamental concepts of guided wave propagation and its implementation for SHM is explained. Following sections present the different modeling schemes adopted, developments in the area of transducers for generation, and sensing of wave, signal processing and imaging technique, statistical and machine learning schemes for feature extraction. Next, a section is presented on the recent advancements in nonlinear guided wave for SHM. This is followed by section on Rayleigh and SH waves. Next is a section on real-life implementation of guided wave for industrial problems. The paper, though briefly talks about the early development for completeness, is primarily focussed on the recent progress made in the last decade. The paper ends by discussing and highlighting the future directions and open areas of research in guided wave based SHM. (topical review)

  14. Structure- and oil type-based efficacy of emulsion adjuvants.

    Science.gov (United States)

    Jansen, Theo; Hofmans, Marij P M; Theelen, Marc J G; Manders, Frans; Schijns, Virgil E J C

    2006-06-29

    Oil-based emulsions are well-known immunopotentiators for inactivated, "killed" vaccines. We addressed the relationship between emulsion structure and levels of in vivo antibody formation to inactivated New Castle Disease virus (NDV) and Infectious Bronchitis virus (IBV) as antigens in 3-week-old chickens. The use of a polymeric emulsifier allowed for direct comparison of three types of emulsions, water-in-oil (W/O), oil-in-water (O/W) and W/O-in-water (W/O/W), while maintaining an identical content of components for each vehicle. They were prepared with either non-metabolizable, mineral oil or metabolizable, Miglyol 840. In addition, we assessed the inherent release capacity of each emulsion variant in vitro. Remarkably, we noted that W/O-type emulsions induced the best immune responses, while they released no antigen during 3 weeks. In general, mineral oil vaccines showed superior efficacy compared to Miglyol 840-based vaccines.

  15. Sparse data structure design for wavelet-based methods

    Directory of Open Access Journals (Sweden)

    Latu Guillaume

    2011-12-01

    Full Text Available This course gives an introduction to the design of efficient datatypes for adaptive wavelet-based applications. It presents some code fragments and benchmark technics useful to learn about the design of sparse data structures and adaptive algorithms. Material and practical examples are given, and they provide good introduction for anyone involved in the development of adaptive applications. An answer will be given to the question: how to implement and efficiently use the discrete wavelet transform in computer applications? A focus will be made on time-evolution problems, and use of wavelet-based scheme for adaptively solving partial differential equations (PDE. One crucial issue is that the benefits of the adaptive method in term of algorithmic cost reduction can not be wasted by overheads associated to sparse data management.

  16. Piezoelectric micromotor based on the structure of serial bending arms.

    Science.gov (United States)

    Tong, Jianhua; Cui, Tianhong; Shao, Peige; Wang, Liding

    2003-09-01

    This paper presents a new piezoelectric micromotor based on the structure of serial bending arms. Serial bending arms are composed of two piezoelectric bimorphs with one end fixed and the other end free, driven by two signals of a biased square wave with a phase difference of pi/2. The free end of a cantilever arm will move along an elliptic orbit so that the cantilever is used to drive a cylinder rotor. The rotor's end surface contacts the free end of the cantilever, resulting in the rotor's rotation. There are six serial bending arms anchored on the base. The driving mechanism of the micromotor is proposed and analyzed. A new micromotor prototype, 5 mm in diameter, has been fabricated and characterized. The maximum rotational speed reaches 325 rpm, and the output torque is about 36.5 microNm.

  17. Development of microwave amplifier based on gallium nitride semiconductor structures

    International Nuclear Information System (INIS)

    Pavlov, D.Yi.; Prokopenko, O.V.; Tsvyirko, Yu.A.; Pavlov, Yi.L.

    2014-01-01

    Microwave properties of microwave amplifier based on gallium nitride (GN) semiconductor structures has been calculated numerically. We proposed the method of numerical calculation of device. This method is accurately sets the value of its characteristics depending on the elements that are used in design of amplifier. It is shown that the device based on GN HEMT-transistors could have amplification factor about 50 dB, while its sizes are 27x18x5.5 mm 3 . Also was provided the absolute stability an amplifier in the whole operating frequency range. It is quite important when using this type of amplifiers in different conditions of exploitation and various fields of use the radioelectronic equipment

  18. Structural analysis of nanocomposites based on HDPE/EPDM blends.

    Science.gov (United States)

    Zitzumbo, Roberto; Alonso, Sergio; Avalos, Felipe; Ortiz, José C; López-Manchado, Miguel A; Arroyo, Miguel

    2006-02-01

    Intercalated and exfoliated nanocomposites based on HDPE and EPDM blends with an organoclay have been obtained through the addition of EPDM-g-MA as a compatibilizer. The combined effect of clay and EPDM-g-MA on the rheological behaviour is very noticeable with a sensible increase in viscosity which suggests the formation of a structural net of percolation induced by the presence of intercalated and exfoliated silicate layer. As deduced from rheological studies, a morphology based on nanostructured micro-domains dispersed in HDPE continuous phase is proposed for EPDM/HDPE blend nanocomposites. XRD and SEM analysis suggest that two different transport phenomena take simultaneously place during the intercalation process in the melt. One due to diffusion of HDPE chains into the tactoid and the other to diffusion of EPDM-g-MA into the silicate galleries.

  19. Performance characterization of structured light-based fingerprint scanner

    Science.gov (United States)

    Hassebrook, Laurence G.; Wang, Minghao; Daley, Raymond C.

    2013-05-01

    Our group believes that the evolution of fingerprint capture technology is in transition to include 3-D non-contact fingerprint capture. More specifically we believe that systems based on structured light illumination provide the highest level of depth measurement accuracy. However, for these new technologies to be fully accepted by the biometric community, they must be compliant with federal standards of performance. At present these standards do not exist for this new biometric technology. We propose and define a set of test procedures to be used to verify compliance with the Federal Bureau of Investigation's image quality specification for Personal Identity Verification single fingerprint capture devices. The proposed test procedures include: geometric accuracy, lateral resolution based on intensity or depth, gray level uniformity and flattened fingerprint image quality. Several 2-D contact analogies, performance tradeoffs and optimization dilemmas are evaluated and proposed solutions are presented.

  20. Automatic Structure-Based Code Generation from Coloured Petri Nets

    DEFF Research Database (Denmark)

    Kristensen, Lars Michael; Westergaard, Michael

    2010-01-01

    Automatic code generation based on Coloured Petri Net (CPN) models is challenging because CPNs allow for the construction of abstract models that intermix control flow and data processing, making translation into conventional programming constructs difficult. We introduce Process-Partitioned CPNs...... (PP-CPNs) which is a subclass of CPNs equipped with an explicit separation of process control flow, message passing, and access to shared and local data. We show how PP-CPNs caters for a four phase structure-based automatic code generation process directed by the control flow of processes....... The viability of our approach is demonstrated by applying it to automatically generate an Erlang implementation of the Dynamic MANET On-demand (DYMO) routing protocol specified by the Internet Engineering Task Force (IETF)....

  1. Design of Composite Structures Using Knowledge-Based and Case Based Reasoning

    Science.gov (United States)

    Lambright, Jonathan Paul

    1996-01-01

    A method of using knowledge based and case based reasoning to assist designers during conceptual design tasks of composite structures was proposed. The cooperative use of heuristics, procedural knowledge, and previous similar design cases suggests a potential reduction in design cycle time and ultimately product lead time. The hypothesis of this work is that the design process of composite structures can be improved by using Case-Based Reasoning (CBR) and Knowledge-Based (KB) reasoning in the early design stages. The technique of using knowledge-based and case-based reasoning facilitates the gathering of disparate information into one location that is easily and readily available. The method suggests that the inclusion of downstream life-cycle issues into the conceptual design phase reduces potential of defective, and sub-optimal composite structures. Three industry experts were interviewed extensively. The experts provided design rules, previous design cases, and test problems. A Knowledge Based Reasoning system was developed using the CLIPS (C Language Interpretive Procedural System) environment and a Case Based Reasoning System was developed using the Design Memory Utility For Sharing Experiences (MUSE) xviii environment. A Design Characteristic State (DCS) was used to document the design specifications, constraints, and problem areas using attribute-value pair relationships. The DCS provided consistent design information between the knowledge base and case base. Results indicated that the use of knowledge based and case based reasoning provided a robust design environment for composite structures. The knowledge base provided design guidance from well defined rules and procedural knowledge. The case base provided suggestions on design and manufacturing techniques based on previous similar designs and warnings of potential problems and pitfalls. The case base complemented the knowledge base and extended the problem solving capability beyond the existence of

  2. Crack diagnosis of metallic profiles based on structural damage indicators

    International Nuclear Information System (INIS)

    Preisler, A; Schröder, K-U; Steenbock, C

    2015-01-01

    Structural Health Monitoring (SHM) faces several challenges before large-scale industrial application. First of all damage diagnosis has to be reliable. Therefore, common SHM approaches use highly advanced sensor techniques to monitor the whole structure on all possible failures. This results in an enormous amount of data gathered during service. The general effort can be drastically reduced, if the knowledge achieved during the sizing process is used. During sizing, potential failure modes and critical locations, so called hot spots, are already evaluated. A very sensitive SHM system can be developed, when the monitoring effort shifts from the damage to its impact on the structural behaviour and the so called damage indicators. These are the two main components of the SmartSHM approach, which reduces the monitoring effort significantly. Not only the amount of data is minimized, but also reliability and robustness are ensured by the SmartSHM approach.This contribution demonstrates the SmartSHM approach by a cracked four point bending beam. To show general applicability a parametric study considering different profiles (bar, box, I, C, T, L, Z), crack positions and lengths has been performed. Questions of sensitivity and minimum size of the sensor network are discussed based on the results of the parametric study. (paper)

  3. Scalable, ultra-resistant structural colors based on network metamaterials

    KAUST Repository

    Galinski, Henning

    2017-05-05

    Structural colors have drawn wide attention for their potential as a future printing technology for various applications, ranging from biomimetic tissues to adaptive camouflage materials. However, an efficient approach to realize robust colors with a scalable fabrication technique is still lacking, hampering the realization of practical applications with this platform. Here, we develop a new approach based on large-scale network metamaterials that combine dealloyed subwavelength structures at the nanoscale with lossless, ultra-thin dielectric coatings. By using theory and experiments, we show how subwavelength dielectric coatings control a mechanism of resonant light coupling with epsilon-near-zero regions generated in the metallic network, generating the formation of saturated structural colors that cover a wide portion of the spectrum. Ellipsometry measurements support the efficient observation of these colors, even at angles of 70°. The network-like architecture of these nanomaterials allows for high mechanical resistance, which is quantified in a series of nano-scratch tests. With such remarkable properties, these metastructures represent a robust design technology for real-world, large-scale commercial applications.

  4. Synthesis/literature review for determining structural layer coefficients (SLC) of bases.

    Science.gov (United States)

    2014-12-01

    FDOTs current method of determining a base material structural layer coefficient (SLC) is detailed in the : Materials Manual, Chapter 2.1, Structural Layer Coefficients for Flexible Pavement Base Materials. : Currently, any new base material not a...

  5. An Implementation of Problem-Based Learning (PBL in Postgraduate Engineering Education According to the Students Uma Implementação da Aprendizagem Baseada em Problemas (PBL na Pós-Graduação em Engenharia sob a Ótica dos Alunos

    Directory of Open Access Journals (Sweden)

    Maria da Graça Nicoletti Mizukami

    2004-11-01

    Full Text Available Problem-based Learning (PBL is an instructional method that – contrary to conventional models that place application problems after the introduction of a concept or content – uses a problem to motivate, focus and initiate learning. Besides promoting the construction of knowledge, this methodology aims at the development of skills and attitudes deemed as important for effective professional practice. This research, of a qualitative nature, analyses a PBL implementation developed in a course of the postgraduate engineering curriculum at a public university in Brazil. The data were collected through participant observation, non-structured interviews and an end-of-semester questionnaire, when the students were asked to evaluate the methodology, its advantages and disadvantages and its attainment to the course educational goals, i.e., knowledge, skills and attitudes. Despite increasing their study time and workload, most of the students favored the methodology for providing more motivating and active classes, and for assisting in the development of interpersonal, research and problem-solving skills as well as attitudes such as respect for other points of view, adaptability, self-directed learning, collaboration etc.A Aprendizagem Baseada em Problemas ou PBL (Problem-Based Learning, ao contrário do modelo convencional, usa o problema para motivar, focar e iniciar a aprendizagem. Além de promover a construção dos conhecimentos a PBL objetiva o desenvolvimento de habilidades e atitudes tidas como importantes para uma prática profissional efetiva. Este trabalho, uma pesquisa-intervenção de natureza qualitativa, analisa a avaliação de alunos sobre uma implementação da PBL em uma disciplina de pós-graduação em engenharia de uma universidade pública em São Carlos, SP. Os dados utilizados neste trabalho foram coletados por meio de observação participante, entrevistas não estruturadas e de um questionário de final de curso respondido

  6. Feedback structure based entropy approach for multiple-model estimation

    Institute of Scientific and Technical Information of China (English)

    Shen-tu Han; Xue Anke; Guo Yunfei

    2013-01-01

    The variable-structure multiple-model (VSMM) approach, one of the multiple-model (MM) methods, is a popular and effective approach in handling problems with mode uncertainties. The model sequence set adaptation (MSA) is the key to design a better VSMM. However, MSA methods in the literature have big room to improve both theoretically and practically. To this end, we propose a feedback structure based entropy approach that could find the model sequence sets with the smallest size under certain conditions. The filtered data are fed back in real time and can be used by the minimum entropy (ME) based VSMM algorithms, i.e., MEVSMM. Firstly, the full Markov chains are used to achieve optimal solutions. Secondly, the myopic method together with particle filter (PF) and the challenge match algorithm are also used to achieve sub-optimal solutions, a trade-off between practicability and optimality. The numerical results show that the proposed algorithm provides not only refined model sets but also a good robustness margin and very high accuracy.

  7. Protein Function Prediction Based on Sequence and Structure Information

    KAUST Repository

    Smaili, Fatima Z.

    2016-05-25

    The number of available protein sequences in public databases is increasing exponentially. However, a significant fraction of these sequences lack functional annotation which is essential to our understanding of how biological systems and processes operate. In this master thesis project, we worked on inferring protein functions based on the primary protein sequence. In the approach we follow, 3D models are first constructed using I-TASSER. Functions are then deduced by structurally matching these predicted models, using global and local similarities, through three independent enzyme commission (EC) and gene ontology (GO) function libraries. The method was tested on 250 “hard” proteins, which lack homologous templates in both structure and function libraries. The results show that this method outperforms the conventional prediction methods based on sequence similarity or threading. Additionally, our method could be improved even further by incorporating protein-protein interaction information. Overall, the method we use provides an efficient approach for automated functional annotation of non-homologous proteins, starting from their sequence.

  8. (Biodegradable Ionomeric Polyurethanes Based on Xanthan: Synthesis, Properties, and Structure

    Directory of Open Access Journals (Sweden)

    T. V. Travinskaya

    2017-01-01

    Full Text Available New (biodegradable environmentally friendly film-forming ionomeric polyurethanes (IPU based on renewable biotechnological polysaccharide xanthan (Xa have been obtained. The influence of the component composition on the colloidal-chemical and physic-mechanical properties of IPU/Xa and based films, as well as the change of their properties under the influence of environmental factors, have been studied. The results of IR-, PMS-, DMA-, and X-ray scattering study indicate that incorporation of Xa into the polyurethane chain initiates the formation of a new polymer structure different from the structure of the pure IPU (matrix: an amorphous polymer-polymer microdomain has occurred as a result of the chemical interaction of Xa and IPU. It predetermines the degradation of the IPU/Xa films as a whole, unlike the mixed polymer systems, and plays a key role in the improvement of material performance. The results of acid, alkaline hydrolysis, and incubation into the soil indicate the increase of the intensity of degradation processes occurring in the IPU/Xa in comparison with the pure IPU. It has been shown that the introduction of Xa not only imparts the biodegradability property to polyurethane, but also improves the mechanical properties.

  9. Structural, electronic, and hyperfine properties of pure and Ta-doped em>m>-ZrO2

    DEFF Research Database (Denmark)

    Taylor, M.A.; Alonso, R.E.; Errico, L.A.

    2012-01-01

    plane wave plus local orbital (APW+lo) method was applied to treat the electronic structure of the doped system including the atomic relaxations introduced by the impurities in the host in a fully self-consistent way using a supercell approach. Different charge states of the Ta impurity were considered...

  10. Comments on the paper ``Dependence of the magnetization law on structural disorder in amorphous ferromagnets'' by E.M. Chudnovsky

    Science.gov (United States)

    Ignatchenko, V. A.; Iskhakov, R. S.

    1990-11-01

    It is shown that the results of the paper by Chudnovsky are mainly analogous to the results obtained earlier in 1980/82 which became the basis for development of an experimental method used to investigate a structural correlation radius from the law of approach of magnetization to saturation in amorphous alloys.

  11. Development of structural materials on the base of new technology

    International Nuclear Information System (INIS)

    Belov, A.F.; Anoshkin, N.F.

    1982-01-01

    Some results are considered and possibilities which discovered in development of structural materials connected with development of such new technological processes as skull melting of titanium alloys, granule metallurgy, hot isostatic, diffusion welding are estimated. The method of skull melting with remelted skull is developed. The method assures sufficient possibilities for dissolving of high-heat components of charge and obtaining homogeneous ingots of series of new alloys. Granule metallurgy based on crystallization of the metal with high rate in the form of small (up to 300 μkm) particles and subsequent consolidation of them into compact billet discoveres a wide possibilities of creation of new structural material with more high operation indexes. It is noted that developed processes of granule production, their treatment, compacting and thermal treatment of the billets assure production of metal of high quality, satisfied the strong requirements of present standards. The process of hot isostatic pressing at which the workable metal is subjected to through uniform pressure by compressed gas after heating or semultaneously with its heating up to the temperatures of working in gasostats is one of new technological processes. A certain experience of the HIP use for production of compact billets from granules for diffusion welding of the billets is accumulated. This process has a great possibilities for densification of shaped castings. Investigation and application of the diffusion welding represent combination of elements into details of complex form in vacuum at the temperatures low of melting point under effect of small pressures are investigated both in our country and abroad. Diffusion welding gives a wide possibilities in the development of materials with higher properties at the expence of production of products of large dimensions from thin elements with fine-grained structure as well as products with assigned gradient of chemical composition, structure

  12. Structure and magnetic exchange coupling of iron based trilayers

    International Nuclear Information System (INIS)

    Mendus, T.

    1998-12-01

    A study of the structural and magnetic properties of Fe based magnetic trilayers is presented. Sample preparation conditions were altered to achieve the best growth conditions and their effect on the magnetic properties determined. Structural information was obtained from RHEED, AES, STM and MEIS; this is believed to be the first time that MEIS has been used to look at this sort of sample. Magnetic characterisation was determined by MOKE with particular interest paid to the biquadratic coupling. The determination of magnetic coupling as a function of sample morphology was studied oil a series of Fe/Cr/Fe samples. Fe/Au/Fe samples oil MgO substrates were also prepared to facilitate MEIS studies. Results indicate that tile fluctuation model best describes tile observed biquadratic coupling in Fe/Cr/Fe trilayers and that the presence of clean, sharp interfaces is required. Annealing and growth at elevated temperature cause interdiffusion at the interfaces, weakening the biquadratic coupling. MEIS structural data from MgO/Fe/Au/Fe samples shows that tile layer structure is dependent oil thickness. There is an apparent reorganisation of tile Au interlayer between a 'bcc'-Iike phase towards tile bulk fcc phase as the layer thickness increases. MEIS is shown to be a very sensitive probe of the crystalline quality and is a powerful probe for the determination of postdeposition sample morphology. Results from an EC collaboration investigating Co/Cr/Co trilayers are also presented. They showed that interlayer coupling and anisotropy of the samples were very sensitive to the preparation conditions. A decrease in the coupling strength is found for sample growth under non-ideal conditions (growth in an applied field, growth at an angle and delays between layer growth). (author)

  13. Estimativa da produtividade de café com base em um modelo agrometeorológico-espectral

    Directory of Open Access Journals (Sweden)

    Viviane Gomes Cardoso da Rosa

    2010-12-01

    Full Text Available O objetivo deste trabalho foi avaliar um modelo agrometeorológico-espectral, para estimar a produtividade de cafezais. Utilizaram-se imagens do sensor MODIS e dados agrometeorológicos do modelo regional de previsão do tempo (ETA, para fornecer as variáveis de entrada para o modelo agrometeorológico-espectral da mesorregião geográfica sul/sudoeste do estado de Minas Gerais nos anos-agrícolas de 2003/2004 a 2007/2008. A variável espectral de entrada do modelo agrometeorológico-espectral, índice de área foliar (IAF, usada no cálculo da produtividade máxima, foi estimada com o índice de vegetação por diferença normalizada (NDVI, obtido de imagens MODIS. Outras variáveis de entrada no modelo foram: dados meteorológicos gerados pelo modelo ETA e a capacidade de água disponível no solo. Ao comparar a produtividade média estimada pelo modelo com a fornecida oficialmente pelo IBGE, as diferenças relativas obtidas em escala regional foram de: 0,4, 3,0, 5,3, 1,5 e 8,5% para os anos agrícolas 2003/2004, 2004/2005, 2005/2006, 2006/2007 e 2007/2008, respectivamente. O modelo agrometeorólogico-espectral, que tem como base o modelo de Doorenbos & Kassan, foi tão eficaz para estimar a produtividade dos cafezais quanto o modelo oficial do IBGE. Além disso, foi possível espacializar a quebra de produtividade e prever 80% da produtividade final na primeira quinzena de fevereiro, antes do início da colheita

  14. Quantifying vegetation distribution and structure using high resolution drone-based structure-from-motion photogrammetry

    Science.gov (United States)

    Zhang, J.; Okin, G.

    2017-12-01

    Vegetation is one of the most important driving factors of different ecosystem processes in drylands. The structure of vegetation controls the spatial distribution of moisture and heat in the canopy and the surrounding area. Also, the structure of vegetation influences both airflow and boundary layer resistance above the land surface. Multispectral satellite remote sensing has been widely used to monitor vegetation coverage and its change; however, it can only capture 2D images, which do not contain the vertical information of vegetation. In situ observation uses different methods to measure the structure of vegetation, and their results are accurate; however, these methods are laborious and time-consuming, and susceptible to undersampling in spatial heterogeneity. Drylands are sparsely covered by short plants, which allows the drone fly at a relatively low height to obtain ultra-high resolution images. Structure-from-motion (SfM) is a photogrammetric method that was proved to produce 3D model based on 2D images. Drone-based remote sensing can obtain the multiangle images for one object, which can be used to constructed 3D models of vegetation in drylands. Using these images detected by the drone, the orthomosaics and digital surface model (DSM) can be built. In this study, the drone-based remote sensing was conducted in Jornada Basin, New Mexico, in the spring of 2016 and 2017, and three derived vegetation parameters (i.e., canopy size, bare soil gap size, and plant height) were compared with those obtained with field measurement. The correlation coefficient of canopy size, bare soil gap size, and plant height between drone images and field data are 0.91, 0.96, and 0.84, respectively. The two-year averaged root-mean-square error (RMSE) of canopy size, bare soil gap size, and plant height between drone images and field data are 0.61 m, 1.21 m, and 0.25 cm, respectively. The two-year averaged measure error (ME) of canopy size, bare soil gap size, and plant height

  15. A escolha do teste estatístico - um tutorial em forma de apresentação em PowerPoint A PowerPoint®-based guide to assist in choosing the suitable statistical test

    Directory of Open Access Journals (Sweden)

    David Normando

    2010-02-01

    Full Text Available A seleção de métodos apropriados para a análise estatística pode parecer complexa, principalmente para estudantes de pós-graduação e pesquisadores no início da carreira científica. Por outro lado, a apresentação em PowerPoint é uma ferramenta comum para estudantes e pesquisadores. Assim, um tutorial de Bioestatística desenvolvido em uma apresentação em PowerPoint poderia estreitar a distância entre ortodontistas e a Bioestatística. Esse guia proporciona informações úteis e objetivas a respeito de vários métodos estatísticos empregando exemplos relacionados à Odontologia e, mais especificamente, à Ortodontia. Esse tutorial deve ser empregado, principalmente, para o usuário obter algumas respostas a questões comuns relacionadas ao teste mais apropriado para executar comparações entre grupos, examinar correlações e regressões ou analisar o erro do método. Também pode ser obtido auxílio para checar a distribuição dos dados (normal ou anormal e a escolha do gráfico mais adequado para a apresentação dos resultados. Esse guia* pode ainda ser de bastante utilidade para revisores de periódicos examinarem, de forma rápida, a adequabilidade do método estatístico apresentado em um artigo submetido à publicação.Selecting appropriate methods for statistical analysis may be difficult, especially for the students and others in the early phases of the research career. On the other hand, PowerPoint presentation is a very common tool to researchers and dental students, so a statistical guide based on PowerPoint could narrow the gap between orthodontist and the Biostatistics. This guide provides objective and useful information about several statistical methods using examples related to the dental field. A Power-Point presentation is employed to assist the user to find answers to common questions regarding Biostatistics, such as the most appropriate statistical test to compare groups, to make correlations and

  16. Comportamento ingestivo e parâmetros sanguíneos em ovinos que receberam dietas contendo aditivos à base de extratos de própolis em

    Directory of Open Access Journals (Sweden)

    O.P. Prado-Calixto

    Full Text Available RESUMO Objetivou-se avaliar os efeitos do extrato de própolis (LLOSC2 sobre o comportamento ingestivo e os parâmetros sanguíneos em cordeiros alimentados com dieta concentrada. Foram utilizados quatro cordeiros machos, castrados, sem raça definida e com peso médio inicial de 32±1,92kg, mantidos em gaiolas metabólicas individuais durante todo o período experimental. O delineamento experimental foi em quadrado latino 4x4, com quatro animais, quatro dietas e quatro períodos experimentais. As dietas diferiram em relação à adição ou não de extratos de própolis à ração. As dietas testadas diferiam na adição de zero (controle, 1(88,16mg/g de flavonoides, duas (176,32mg/g de flavonoides ou três (264,48mg/g de flavonoides doses de aditivo à base de extrato de própolis LLOSC2. A dieta tinha relação volumoso:concentrado de 40:60 e foi formulada para ganhos de 250g. A ração concentrada era composta de milho e farelo de soja. O comportamento ingestivo dos animais foi observado por 24 horas, divididas em quatro períodos de seis horas. As coletas de sangue eram realizadas no último dia do período. Não houve efeito das doses LLOSC2 sobre o tempo despendido em alimentação, ruminação, ócio e ingestão de água. A duração do ciclo ruminativo foi maior nos animais que receberam duas doses de LLOSC2, e o número de movimentos mastigatórios também tendeu a aumentar no período que compreendia das 13 às 19h. Já a dieta contendo uma dose de LLOSC2 aumentou a duração da ruminação do bolo bem como o seu número total de mastigações no período de uma a sete horas. Houve uma diminuição nos níveis séricos de cortisol com a adição de três doses de LLOSC2. O hemograma, o leucograma, o perfil bioquímico e as imunoglobulinas não foram afetados pela inclusão das doses de LLSOC2. A administração de extrato de própolis LLOSC2 à dieta de ovinos não afetou seu comportamento ingestivo, os parâmetros hematol

  17. Refinamento de imagens termais do Landsat 5 - TM com base em classes de NDVI Sharpening of thermal Landsat 5 - TM imagery data based on NDVI classification

    Directory of Open Access Journals (Sweden)

    Argemiro Lucena de Araújo

    2012-12-01

    Full Text Available O objetivo desse estudo foi avaliar um método simplificado, baseado em classes de NDVI para refinamento das imagens de temperatura da superfície (Ts, obtidas pelo sensor TM do Landsat 5 referentes aos anos de 2005 e 2006. Para tanto, foram propostos e comparados três modelos de refinamento baseados no método de regressão linear. Os erros percentuais e erros médios quadráticos obtidos com a utilização dos modelos avaliados foram, respectivamente, da ordem de 0,37% e 1,38 ºC, enquanto o modelo original apresentou erro médio quadrático da ordem de 1,32 ºC. Foram constatados que os erros obtidos com as calibrações realizadas não influenciaram significativamente nos valores médios das imagens termais, e que os resultados contribuíram substancialmente para a melhoria da resolução espacial das mesmas. O refinamento permitiu ainda a identificação precisa de alvos da superfície e a identificação de feições não detectáveis na resolução original. Isto evidencia que o método simplificado sugerido neste estudo, permite um refinamento preciso com uma forma de obtenção mais simples em relação ao modelo original.The objective of this study was to use a simplified method based on NDVI classes for the sharpening of the Landsat 5 - TM surface temperature images (Ts obtained during the years of 2005 and 2006. Thus, three sharpening models, based on the linear regression method, were proposed and compared. The relative and the root mean square errors obtained through the suggested models were of 0.37% and 1.38 ºC, respectively, while the original model presented root mean square error of 1.32 ºC. It was verified that the errors obtained with the accomplished calibrations did not significantly influence in the average values of the thermal images and the results contributed substantially to the improvement of their spatial resolution. The sharpening allowed the precise identification of the targets and features undetectable at

  18. Mortalidade perinatal em duas coortes de base populacional no Sul do Brasil: tendências e diferenciais

    Directory of Open Access Journals (Sweden)

    Menezes Ana M. B.

    1996-01-01

    Full Text Available A evolução da mortalidade perinatal foi estudada em Pelotas, Rio Grande do Sul, através de dois estudos de coorte realizados em 1982 e 1993. Todos os nascimentos hospitalares e os óbitos foram monitorizados com visitas diárias aos hospitais. A causa da morte foi determinada através de informações do prontuário, entrevista com o pediatra e de necrópsias. O coeficiente de mortalidade perinatal sofreu uma redução de 31% na década. O sub-registro que era de 42,1% em 1982, foi de apenas 6,8% em 1993. Dentre as causas de mortalidade perinatal, houve uma redução em 1993 de 58% para óbitos fetais antepartum, 47% para imaturidade e 62% para outras causas. Os coeficientes para asfixia sofreram um aumento de 4,5/1.000 para 8,3/1.000. As meninas apresentaram um coeficiente de mortalidade perinatal menor do que os meninos. Os coeficientes de mortalidade perinatal conforme peso ao nascer e renda familiar sofreram importantes reduções, sendo que a mais notável foi para crianças de baixo peso e de famílias de renda alta, com uma queda de 68%. Assim como em 1982, os recém-nascidos pré-termo tiveram coeficientes três vezes mais elevados do que crianças pequenas para a idade gestacional. Apesar da queda dos índices de mortalidade na década, as diferenças entre os grupos sociais mantiveram-se grandes.

  19. Analysis of a Frame-Shear Wall Concrete Structure by Using Base Isolation and Evaluation of Structure-Soil Interaction

    Directory of Open Access Journals (Sweden)

    H. I. Polat

    2017-12-01

    Full Text Available A base isolation system is a type of earthquake-resistant structure design approach based on the principle of reducing a structure’s earthquake response rather than increasing the structure’s earthquake resistance capacity. Seismic base isolated structures have the ability to make large displacements relative to the level of insulation elements. This means that a large structure performs very small displacements between floors during an earthquake and exhibits a rigid body behavior. At this point, the earthquake forces acting on the structure decrease along with the floors. In this article a school building composed of frame-shear wall is resolved primarily with the traditional fixed base structure system, mode shapes are found and periods are obtained. For earthquake response analysis, earthquake loads are distributed to the floors using the equivalent seismic load method and structural elements experiencing capacity problems are found. Then, using the earthquake record, larger failure of cross sections and capacity problems are obtained compared to the first method. In the second stage, the same structure is dissolved again by placing the lead core rubber base isolators between the base and the vertical structural members. The periods of structures under earthquake load have increased significantly by utilizing base isolation, as a result of that spectral accelerations decreased. Thus, large decreases in the shear forces acting to the structure are determined and failures of cross sections are removed.

  20. Prediction of protein-protein interactions in dengue virus coat proteins guided by low resolution cryoEM structures

    Directory of Open Access Journals (Sweden)

    Srinivasan Narayanaswamy

    2010-06-01

    Full Text Available Abstract Background Dengue virus along with the other members of the flaviviridae family has reemerged as deadly human pathogens. Understanding the mechanistic details of these infections can be highly rewarding in developing effective antivirals. During maturation of the virus inside the host cell, the coat proteins E and M undergo conformational changes, altering the morphology of the viral coat. However, due to low resolution nature of the available 3-D structures of viral assemblies, the atomic details of these changes are still elusive. Results In the present analysis, starting from Cα positions of low resolution cryo electron microscopic structures the residue level details of protein-protein interaction interfaces of dengue virus coat proteins have been predicted. By comparing the preexisting structures of virus in different phases of life cycle, the changes taking place in these predicted protein-protein interaction interfaces were followed as a function of maturation process of the virus. Besides changing the current notion about the presence of only homodimers in the mature viral coat, the present analysis indicated presence of a proline-rich motif at the protein-protein interaction interface of the coat protein. Investigating the conservation status of these seemingly functionally crucial residues across other members of flaviviridae family enabled dissecting common mechanisms used for infections by these viruses. Conclusions Thus, using computational approach the present analysis has provided better insights into the preexisting low resolution structures of virus assemblies, the findings of which can be made use of in designing effective antivirals against these deadly human pathogens.

  1. Structure and function based design of Plasmodium-selective proteasome inhibitors

    Science.gov (United States)

    Li, Hao; O'Donoghue, Anthony J.; van der Linden, Wouter A.; Xie, Stanley C.; Yoo, Euna; Foe, Ian T.; Tilley, Leann; Craik, Charles S.; da Fonseca, Paula C. A.; Bogyo, Matthew

    2016-01-01

    The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen presentation1. Compounds that target the proteasome are potentially valuable tools for the treatment of pathogens that depend on proteasome function for survival and replication. In particular, proteasome inhibitors have been shown to be toxic for the malaria parasite Plasmodium falciparum at all stages of its life cycle2-5. Most compounds that have been tested against the parasite also inhibit the mammalian proteasome resulting in toxicity that precludes their use as therapeutic agents2,6. Therefore, better definition of the substrate specificity and structural properties of the Plasmodium proteasome could enable the development of compounds with sufficient selectivity to allow their use as anti-malarial agents. To accomplish this goal, we used a substrate profiling method to uncover differences in the specificities of the human and P. falciparum proteasome. We designed inhibitors based on amino acid preferences specific to the parasite proteasome, and found that they preferentially inhibit the β 2 subunit. We determined the structure of the P. falciparum 20S proteasome bound to the inhibitor using cryo-electron microscopy (cryo-EM) and single particle analysis, to a resolution of 3.6 Å. These data reveal the unusually open P. falciparum β2 active site and provide valuable information regarding active site architecture that can be used to further refine inhibitor design. Furthermore, consistent with the recent finding that the proteasome is important for stress pathways associated with resistance of artemisinin (ART) family anti-malarials7,8, we observed growth inhibition synergism with low doses of this β 2 selective inhibitor in ART sensitive and resistant parasites. Finally, we demonstrated that a parasite selective inhibitor could be used to attenuate parasite growth in vivo without significant toxicity to the host. Thus, the

  2. Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii

    Institute of Scientific and Technical Information of China (English)

    Zhifei Li; Qiang Guo; Lvqin Zheng; Yongsheng Ji; Yi-Ting Xie; De-Hua Lai; Zhao-Rong Lun; Xun Suo; Ning Gao

    2017-01-01

    As an indispensable molecular machine universal in all living organisms,the ribosome has been selected by evolution to be the natural target of many antibiotics and small-molecule inhibitors.High-resolution structures of pathogen ribosomes are crucial for understanding the general and unique aspects of translation control in disease-causing microbes.With cryo-electron microscopy technique,we have determined structures of the cytosolic ribosomes from two human parasites,Trichomonas vaginalis and Toxoplasma gondii,at resolution of 3.2-3.4,(A).Although the ribosomal proteins from both pathogens are typical members of eukaryotic families,with a co-evolution pattern between certain species-specific insertions/extensions and neighboring ribosomal RNA (rRNA) expansion segments,the sizes of their rRNAs are sharply different.Very interestingly,rRNAs of T.vaginalis are in size comparable to prokaryotic counterparts,with nearly all the eukaryote-specific rRNA expansion segments missing.These structures facilitate the dissection of evolution path for ribosomal proteins and RNAs,and may aid in design of novel translation inhibitors.

  3. Desenvolvendo um processo de análise de investimentos baseado em competências Developping an investimento analysis process based on competences

    Directory of Open Access Journals (Sweden)

    Ronald Nieweglowski

    2010-01-01

    de investimento, fundamentando-se em uma abordagem de natureza estratégica.The organisational competences that an enterprise uses in its operations potentially define its capacity for implementing its business strategy. The present paper proposes a process for the analysis of investment projects based on competences. The study is focused on small enterprises, and it is applied to capacity expansion projects. The developed approach is based on a theoretical framework refined through a round of interviews conducted with experienced professionals. Three investment analysts and three academics that work in the strategic operations management and economic production management areas participated in the interviews. The developed process was tested in simulation studies using the results of three investment projects analyzed by a development bank in the period of March 2002 to September 2003. The cases are related to manufacturing, commerce, and service sectors. The result of this work is an investment analysis process that uses the enterprise competences concept to evaluate its capability to generate results. The process relates resources and competences to the adopted business strategy. The study nature is exploratory and, in this sense, it does not allow generalizations. It is necessary to increase the number of simulations and to test the process using different investment analysts. The major practical implication is related to the fact that a structured procedure was proposed for the analysis of investment projects for small companies due to the difficulty of obtaining accurate and reliable financial and economic information about those companies. This study contributes to the development of methodologies for the analysis of investment projects based on a strategic approach.

  4. A primer on polymer nomenclature: Structure-based, sourced-based and trade names

    Science.gov (United States)

    Polymer nomenclature is important because it is part of the language of polymer science and is needed for polymer identification, reference, and documentation. A primer on polymer nomenclature is provided herein for people new to the field or for instructional use. Both structure-based and source-...

  5. Reliability-based design code calibration for concrete containment structures

    International Nuclear Information System (INIS)

    Han, B.K.; Cho, H.N.; Chang, S.P.

    1991-01-01

    In this study, a load combination criteria for design and a probability-based reliability analysis were proposed on the basis of a FEM-based random vibration analysis. The limit state model defined for the study is a serviceability limit state of the crack failure that causes the emission of radioactive materials, and the results are compared with the case of strength limit state. More accurate reliability analyses under various dynamic loads such as earthquake loads were made possible by incorporating the FEM and random vibration theory, which is different from the conventional reliability analysis method. The uncertainties in loads and resistance available in Korea and the references were adapted to the situation of Korea, and especially in case of earthquake, the design earthquake was assessed based on the available data for the probabilistic description of earthquake ground acceleration in the Korea peninsula. The SAP V-2 is used for a three-dimensional finite element analysis of concrete containment structure, and the reliability analysis is carried out by modifying HRAS reliability analysis program for this study. (orig./GL)

  6. Análise do processo de gestão do conhecimento em uma empresa de base tecnológica da cidade de Joinville-SC

    Directory of Open Access Journals (Sweden)

    Evelin Priscila Trindade

    2015-07-01

    Full Text Available Atualmente o conhecimento é considerado o principal fator de produção das organizações. Dentre as empresas que mais se destacam como intensivas em conhecimento, estão as organizações de base tecnológica. Assim, o objetivo do presente estudo é mostrar as ações de gestão do conhecimento realizadas por uma empresa de base tecnológica de Joinville/SC. Foi realizado um estudo de caso qualitativo, de caráter exploratório e explicativo, com utilização de dados primários, coletados em duas etapas. A primeira coleta foi feita por meio de um instrumento de pesquisa com perguntas abertas, enviadas por e-mail, a dois colaboradores da organização em foco; e a segunda, por intermédio de ligações telefônicas para os mesmos colaboradores com o objetivo de conhecer melhor a realidade da empresa e analisar as respostas dadas ao questionário. Dentre os principais resultados encontrados, pode-se citar o fato de a empresa fazer uso de ferramentas como Comunidades de Prática, identificadas na rotina organizacional.

  7. Equilíbrio ácido-base e hidroeletrolítico em eqüinos com cólica

    OpenAIRE

    Di Filippo,Paula Alessandra; Santana,Aureo Evangelista; Pereira,Gener Tadeu

    2008-01-01

    Foram utilizados setenta eqüinos distribuídos em três grupos experimentais, G1 (vinte eqüinos hígidos), G2 (vinte e cinco eqüinos com cólica, os quais passaram por tratamento clínico ou cirúrgico e sobreviveram) e G3 (vinte e cinco eqüinos com cólica, os quais passaram por tratamento clínico ou cirúrgico e foram a óbito ou foram sacrificados). Amostras de sangue foram obtidas em dez diferentes momentos, mediante punção da jugular, para estudo do equilíbrio ácido-base e hidroeletrolítico. Os e...

  8. Shape Memory Alloy-Based Periodic Cellular Structures, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I effort will develop and demonstrate an innovative shape memory alloy (SMA) periodic cellular structural technology. Periodic cellular structures...

  9. Nuclear magnetic resonance in superionic conductors with fluorite-type structure; Ressonancia magnetica nuclear em condutores superionicos de estrutura fluorita

    Energy Technology Data Exchange (ETDEWEB)

    Souto, Sergio Paulo Amaral

    1991-12-31

    The {sup 19} F NMR relaxation times T{sub 1} and T{sub 2} were measured in ternary and nonstoichiometric compounds with the fluorite-type structure. We have studied the Na{sub 0-4} Y{sub 0-6} F{sub 2-2} crystal in the temperature range 600 K to 900 K, where the crystal has not the fluorite structure. The T{sub 1} values were measured in 2 Larmor frequencies: 20.42 MHz and 34.24 MHz. The results for T{sub 1} were seem to be qualitatively similar to those measured in the system with two inequivalent sublattices. The T{sub 2} measurements, in the Pb{sub O84} Bi{sub 0-16} F{sub 2-16} crystal, were made during temperature cycles in the range of 300 K to 830 K. The difference in activation energy between cooling and heating half cycles, found to be approximately 0.08 eV, appear to be associated with the change in the clusters structure and not to the energy of defect formation. Finally, similar T{sub 2} measurements during temperature cycling was made in K{sub 0-4} Bi{sub 0-6} F{sub 2-2} : 2% Pb F{sub 2} crystal, in the temperature range 300 K to 800 K, but in this case no difference in the cooling and heating results was observed. We also measured, in the same temperature range, the T{sub 1} relaxation time in 3 Larmor frequencies: 11.71 MHz, 20.42 MHz and 34.24 Mhz. This results appear to indicate the existence of two hopping mechanism. (author). 132 refs., 68 figs.

  10. Structural Optimization based on the Concept of First Order Analysis

    International Nuclear Information System (INIS)

    Shinji, Nishiwaki; Hidekazu, Nishigaki; Yasuaki, Tsurumi; Yoshio, Kojima; Noboru, Kikuchi

    2002-01-01

    Computer Aided Engineering (CAE) has been successfully utilized in mechanical industries such as the automotive industry. It is, however, difficult for most mechanical design engineers to directly use CAE due to the sophisticated nature of the operations involved. In order to mitigate this problem, a new type of CAE, First Order Analysis (FOA) has been proposed. This paper presents the outcome of research concerning the development of a structural topology optimization methodology within FOA. This optimization method is constructed based on discrete and function-oriented elements such as beam and panel elements, and sequential convex programming. In addition, examples are provided to show the utility of the methodology presented here for mechanical design engineers

  11. VIBRATION ANALYSIS OF TURBINE BASED ON FLUID-STRUCTURE COUPLING

    Institute of Scientific and Technical Information of China (English)

    LIU Demin; LIU Xiaobing

    2008-01-01

    The vibration of a Francis turbine is analyzed with the additional quality matrix method based on fluid-structure coupling (FSC). Firstly, the vibration frequency and mode of blade and runner in air and water are calculated. Secondly, the influences to runner frequency domain by large flow, small flow and design flow working conditions are compared. Finally the influences to runner modes by centrifugal forces under three rotating speeds of 400 r/min, 500 r/min and 600 r/min are compared. The centrifugal force and small flow working condition have greatly influence on the vibration of small runner. With the increase of centrifugal force, the vibration frequency of the runner is sharply increased. Some order frequencies are even close to the runner natural frequency in the air. Because the low frequency vibration will severely damage the stability of the turbine, low frequency vibration of units should be avoided as soon as possible.

  12. Development of piping support structure design software based on PDMS

    International Nuclear Information System (INIS)

    Tang Yongtao; Guan Hui; Su Rongfu; Huang Wei; Mao Huihui

    2014-01-01

    In order to enhance the efficiency of nuclear power process system piping support design, the veracity of interface with support, piping and anchor, and decrease the clash between supports and other disciplines, developed piping support structure design software NPHS based on PDMS independently. That achieved the seamless integration of PDMS and NPHS by method of embedded development, reduce the size of program code, improve the running efficiency; That predigested the 3D modeling and information storage for support parts, that increased the support database opening and maintenance using the special mechanism and configuration of database. The support modeling efficiency due to setting of the connection key point of support parts is improved. Practices in several real nuclear power projects proved that NPHS software is provided with such outstanding performances: quick running, strong stability, accurate data, easy to operate and maintain, and output results satisfied the engineering requirements. (authors)

  13. Glass-based confined structures enabling light control

    Energy Technology Data Exchange (ETDEWEB)

    Chiappini, Andrea; Normani, Simone; Chiasera, Alessandro [IFN–CNR CSMFO Lab., and FBK Photonics Unit via alla Cascata 56/C Povo, 38123 Trento (Italy); Lukowiak, Anna [Institute of Low Temperature and Structure Research PAS, Okolna St. 2, 50-422 Wroclaw (Poland); Vasilchenko, Iustyna [IFN–CNR CSMFO Lab., and FBK Photonics Unit via alla Cascata 56/C Povo, 38123 Trento (Italy); Dipartimento di Fisica, Università di Trento, via Sommarive 14 Povo, 38123Trento (Italy); Ristic, Davor [Institut Ruđer Bošković, Bijenička cesta 54, 10000 Zagreb (Croatia); Boulard, Brigitte [IMMM, CNRS Equipe Fluorures, Université du Maine, Av. Messiaen, 72085 Le Mans cedex 9 (France); Dorosz, Dominik [Department of Power Engineering, Photonics and Lighting Technology, Bialystok University of Technology, Wiejska Street 45D, 15-351 Bialystok (Poland); Scotognella, Francesco [Center for Nano Science and Technology@PoliMi, Istituto Italiano di Tecnologia, Via Giovanni Pascoli, 70/3, 20133, Milan (Italy); Politecnico di Milano, Dipartimento di Fisica and Istituto di Fotonica e Nanotecnologie CNR, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); Vaccari, Alessandro [FBK -CMM, ARES Unit, 38123 Trento (Italy); Taccheo, Stefano [College of Engineering, Swansea University, Singleton Park, SA2 8PP, Swansea (United Kingdom); Pelli, Stefano; Righini, Giancarlo C. [IFAC - CNR, MiPLab., 50019 Sesto Fiorentino (Italy); Museo Storico della Fisica e Centro di Studi e Ricerche “Enrico Fermi”, Piazza del Viminale 1, 00184 Roma (Italy); Conti, Gualtiero Nunzi [IFAC - CNR, MiPLab., 50019 Sesto Fiorentino (Italy); Ramponi, Roberta [Politecnico di Milano, Dipartimento di Fisica and Istituto di Fotonica e Nanotecnologie CNR, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); and others

    2015-04-24

    When a luminescent ion is confined in a system characterized by one or more specific properties such as spatial size, geometrical dimension and shape, refractive index, local crystal field, cut-off vibrational energy and so on, it's possible to control its emission. The control of branching ratios as a function of the composition, the luminescence enhancement induced by a photonic crystal, or the laser action in a microresonator, are well known examples of light control. Photonic glass-based structures are extremely viable systems to exploit the above mentioned properties and in our research team we have successfully fabricated luminescent photonic structures by different techniques, including sol-gel, rf sputtering, drawing, melting, and physical vapour deposition. Here we will discuss some of them with the aim to make the reader aware of the chemical-physical properties related to each specific system. We will demonstrate that glass ceramic waveguides in some cases present superior spectroscopic properties in respect to the parent glass, that compositional properties can play a positive role in reducing luminescence quenching and in developing novel planar waveguides and fibers, that colloids allow to obtain high internal quantum efficiency and that photonic crystals, microcavities and microresonators can enable the handling of the rare earth luminescence. Finally, the pros and cons of the systems and of the different techniques employed for their fabrication will be discussed and some perspectives concerning the glass photonics will be proposed looking at both possible applications and investigation of physical properties.

  14. A Lightweight Structure Redesign Method Based on Selective Laser Melting

    Directory of Open Access Journals (Sweden)

    Li Tang

    2016-11-01

    Full Text Available The purpose of this paper is to present a new design method of lightweight parts fabricated by selective laser melting (SLM based on the “Skin-Frame” and to explore the influence of fabrication defects on SLM parts with different sizes. Some standard lattice parts were designed according to the Chinese GB/T 1452-2005 standard and manufactured by SLM. Then these samples were tested in an MTS Insight 30 compression testing machine to study the trends of the yield process with different structure sizes. A set of standard cylinder samples were also designed according to the Chinese GB/T 228-2010 standard. These samples, which were made of iron-nickel alloy (IN718, were also processed by SLM, and then tested in the universal material testing machine INSTRON 1346 to obtain their tensile strength. Furthermore, a lightweight redesigned method was researched. Then some common parts such as a stopper and connecting plate were redesigned using this method. These redesigned parts were fabricated and some application tests have already been performed. The compression testing results show that when the minimum structure size is larger than 1.5 mm, the mechanical characteristics will hardly be affected by process defects. The cylinder parts were fractured by the universal material testing machine at about 1069.6 MPa. These redesigned parts worked well in application tests, with both the weight and fabrication time of these parts reduced more than 20%.

  15. Convolution neural-network-based detection of lung structures

    Science.gov (United States)

    Hasegawa, Akira; Lo, Shih-Chung B.; Freedman, Matthew T.; Mun, Seong K.

    1994-05-01

    Chest radiography is one of the most primary and widely used techniques in diagnostic imaging. Nowadays with the advent of digital radiology, the digital medical image processing techniques for digital chest radiographs have attracted considerable attention, and several studies on the computer-aided diagnosis (CADx) as well as on the conventional image processing techniques for chest radiographs have been reported. In the automatic diagnostic process for chest radiographs, it is important to outline the areas of the lungs, the heart, and the diaphragm. This is because the original chest radiograph is composed of important anatomic structures and, without knowing exact positions of the organs, the automatic diagnosis may result in unexpected detections. The automatic extraction of an anatomical structure from digital chest radiographs can be a useful tool for (1) the evaluation of heart size, (2) automatic detection of interstitial lung diseases, (3) automatic detection of lung nodules, and (4) data compression, etc. Based on the clearly defined boundaries of heart area, rib spaces, rib positions, and rib cage extracted, one should be able to use this information to facilitate the tasks of the CADx on chest radiographs. In this paper, we present an automatic scheme for the detection of lung field from chest radiographs by using a shift-invariant convolution neural network. A novel algorithm for smoothing boundaries of lungs is also presented.

  16. Structured Light-Based 3D Reconstruction System for Plants.

    Science.gov (United States)

    Nguyen, Thuy Tuong; Slaughter, David C; Max, Nelson; Maloof, Julin N; Sinha, Neelima

    2015-07-29

    Camera-based 3D reconstruction of physical objects is one of the most popular computer vision trends in recent years. Many systems have been built to model different real-world subjects, but there is lack of a completely robust system for plants. This paper presents a full 3D reconstruction system that incorporates both hardware structures (including the proposed structured light system to enhance textures on object surfaces) and software algorithms (including the proposed 3D point cloud registration and plant feature measurement). This paper demonstrates the ability to produce 3D models of whole plants created from multiple pairs of stereo images taken at different viewing angles, without the need to destructively cut away any parts of a plant. The ability to accurately predict phenotyping features, such as the number of leaves, plant height, leaf size and internode distances, is also demonstrated. Experimental results show that, for plants having a range of leaf sizes and a distance between leaves appropriate for the hardware design, the algorithms successfully predict phenotyping features in the target crops, with a recall of 0.97 and a precision of 0.89 for leaf detection and less than a 13-mm error for plant size, leaf size and internode distance.

  17. Generating inferences from knowledge structures based on general automata

    Energy Technology Data Exchange (ETDEWEB)

    Koenig, E C

    1983-01-01

    The author shows that the model for knowledge structures for computers based on general automata accommodates procedures for establishing inferences. Algorithms are presented which generate inferences as output of a computer when its sentence input names appropriate knowledge elements contained in an associated knowledge structure already stored in the memory of the computer. The inferences are found to have either a single graph tuple or more than one graph tuple of associated knowledge. Six algorithms pertain to a single graph tuple and a seventh pertains to more than one graph tuple of associated knowledge. A named term is either the automaton, environment, auxiliary receptor, principal receptor, auxiliary effector, or principal effector. The algorithm pertaining to more than one graph tuple requires that the input sentence names the automaton, transformation response, and environment of one of the tuples of associated knowledge in a sequence of tuples. Interaction with the computer may be either in a conversation or examination mode. The algorithms are illustrated by an example. 13 references.

  18. Structured Light-Based 3D Reconstruction System for Plants

    Directory of Open Access Journals (Sweden)

    Thuy Tuong Nguyen

    2015-07-01

    Full Text Available Camera-based 3D reconstruction of physical objects is one of the most popular computer vision trends in recent years. Many systems have been built to model different real-world subjects, but there is lack of a completely robust system for plants. This paper presents a full 3D reconstruction system that incorporates both hardware structures (including the proposed structured light system to enhance textures on object surfaces and software algorithms (including the proposed 3D point cloud registration and plant feature measurement. This paper demonstrates the ability to produce 3D models of whole plants created from multiple pairs of stereo images taken at different viewing angles, without the need to destructively cut away any parts of a plant. The ability to accurately predict phenotyping features, such as the number of leaves, plant height, leaf size and internode distances, is also demonstrated. Experimental results show that, for plants having a range of leaf sizes and a distance between leaves appropriate for the hardware design, the algorithms successfully predict phenotyping features in the target crops, with a recall of 0.97 and a precision of 0.89 for leaf detection and less than a 13-mm error for plant size, leaf size and internode distance.

  19. Glass-based confined structures enabling light control

    International Nuclear Information System (INIS)

    Chiappini, Andrea; Normani, Simone; Chiasera, Alessandro; Lukowiak, Anna; Vasilchenko, Iustyna; Ristic, Davor; Boulard, Brigitte; Dorosz, Dominik; Scotognella, Francesco; Vaccari, Alessandro; Taccheo, Stefano; Pelli, Stefano; Righini, Giancarlo C.; Conti, Gualtiero Nunzi; Ramponi, Roberta

    2015-01-01

    When a luminescent ion is confined in a system characterized by one or more specific properties such as spatial size, geometrical dimension and shape, refractive index, local crystal field, cut-off vibrational energy and so on, it's possible to control its emission. The control of branching ratios as a function of the composition, the luminescence enhancement induced by a photonic crystal, or the laser action in a microresonator, are well known examples of light control. Photonic glass-based structures are extremely viable systems to exploit the above mentioned properties and in our research team we have successfully fabricated luminescent photonic structures by different techniques, including sol-gel, rf sputtering, drawing, melting, and physical vapour deposition. Here we will discuss some of them with the aim to make the reader aware of the chemical-physical properties related to each specific system. We will demonstrate that glass ceramic waveguides in some cases present superior spectroscopic properties in respect to the parent glass, that compositional properties can play a positive role in reducing luminescence quenching and in developing novel planar waveguides and fibers, that colloids allow to obtain high internal quantum efficiency and that photonic crystals, microcavities and microresonators can enable the handling of the rare earth luminescence. Finally, the pros and cons of the systems and of the different techniques employed for their fabrication will be discussed and some perspectives concerning the glass photonics will be proposed looking at both possible applications and investigation of physical properties

  20. Possible seismogenic origin of changes in the ULF EM resonant structure observed at Teoloyucan geomagnetic station, Mexico, 1999-2001

    Directory of Open Access Journals (Sweden)

    A. Kotsarenko

    2005-01-01

    Full Text Available The evolution of the ULF resonant structure observed at Teoloyucan geomagnetic station has been provisionally studied in a possible relation with seismic activity in Mexico in the period 1999-2001. Two resonant lines were observed in the H-component (linear polarization in the frequency bands fR2=10.2–11.1 mHz and fR2=13.6–14.5 mHz, sometimes accompanied by other harmonics. The source of the observed resonances is possibly related with the geomagnetic location of the station (geomagnetic latitude λ=29.1° and its proximity to the equatorial electrojet (λ~30°. An enhancement of the carrier frequency of both resonances in the period 1 month–2 weeks was found before the strongest EQs. Also, a depression of the resonant structure just a few days before and a few days after some EQs seems to be correlated with seismic activity.

  1. Compressive sensing based wireless sensor for structural health monitoring

    Science.gov (United States)

    Bao, Yuequan; Zou, Zilong; Li, Hui

    2014-03-01

    Data loss is a common problem for monitoring systems based on wireless sensors. Reliable communication protocols, which enhance communication reliability by repetitively transmitting unreceived packets, is one approach to tackle the problem of data loss. An alternative approach allows data loss to some extent and seeks to recover the lost data from an algorithmic point of view. Compressive sensing (CS) provides such a data loss recovery technique. This technique can be embedded into smart wireless sensors and effectively increases wireless communication reliability without retransmitting the data. The basic idea of CS-based approach is that, instead of transmitting the raw signal acquired by the sensor, a transformed signal that is generated by projecting the raw signal onto a random matrix, is transmitted. Some data loss may occur during the transmission of this transformed signal. However, according to the theory of CS, the raw signal can be effectively reconstructed from the received incomplete transformed signal given that the raw signal is compressible in some basis and the data loss ratio is low. This CS-based technique is implemented into the Imote2 smart sensor platform using the foundation of Illinois Structural Health Monitoring Project (ISHMP) Service Tool-suite. To overcome the constraints of limited onboard resources of wireless sensor nodes, a method called random demodulator (RD) is employed to provide memory and power efficient construction of the random sampling matrix. Adaptation of RD sampling matrix is made to accommodate data loss in wireless transmission and meet the objectives of the data recovery. The embedded program is tested in a series of sensing and communication experiments. Examples and parametric study are presented to demonstrate the applicability of the embedded program as well as to show the efficacy of CS-based data loss recovery for real wireless SHM systems.

  2. Non-Watson Crick base pairs might stabilize RNA structural motifs in ...

    Indian Academy of Sciences (India)

    Watson Crick base pairs, internal loops and pseudoknots have been the highlighting feature of recent structural determination of RNAs. The recent crystal structure of group-I introns has demonstrated that these might constitute RNA structural ...

  3. Loading and stress analysis of gas pipeline structures; Analise de esforcos e tensoes em estruturas de gasodutos durante despressurizacoes

    Energy Technology Data Exchange (ETDEWEB)

    Frisoli, Caetano [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil); Frota, Cristiane Souto [TBG - Transportadora Brasileira Gasoduto Bolivia Brasil S.A., Rio de Janeiro, RJ (Brazil); Silva, Luis Fernando Figueira da; Carvalho, Marcio da Silveira [Pontificia Univ. Catolica do Rio de Janeiro, RJ (Brazil). Dept. de Engenharia Mecanica; Savi, Marcelo Amorim [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia. Dept. de Engenharia Mecanica; Pacheco, Pedro Manuel Calas Lopes [Centro Federal de Educacao Tecnologica do Rio de Janeiro (CEFET-RJ), Rio de Janeiro, RJ (Brazil)

    2003-07-01

    Repairing and maintenance activities on Bolivia-Brazil gas pipeline often need blow down lines. During the blow down process, the high speed of discharging gases imposes great efforts to the structures. A detailed analysis of this situation is essential for a safe operation. This paper describes two phases of a project, developed under TBG coordination. It consists in analyzing the stress and forces involved in this operation, in order to design facilities to blow down pipes and develop a safe blow down procedure for the gas pipeline. The first phase consists of a supersonic flowing simulation in the blow down gas pipeline device. The pressure behavior, mass flow and the speed at the device's ending point are calculated for different operational conditions. In the second phase, the equivalent loading caused by blow down operations is used as input in a stress analysis program to determine stress, critical sessions evaluation and material recommendations for blow down devices. (author)

  4. Facial Image Compression Based on Structured Codebooks in Overcomplete Domain

    Directory of Open Access Journals (Sweden)

    Vila-Forcén JE

    2006-01-01

    Full Text Available We advocate facial image compression technique in the scope of distributed source coding framework. The novelty of the proposed approach is twofold: image compression is considered from the position of source coding with side information and, contrarily to the existing scenarios where the side information is given explicitly; the side information is created based on a deterministic approximation of the local image features. We consider an image in the overcomplete transform domain as a realization of a random source with a structured codebook of symbols where each symbol represents a particular edge shape. Due to the partial availability of the side information at both encoder and decoder, we treat our problem as a modification of the Berger-Flynn-Gray problem and investigate a possible gain over the solutions when side information is either unavailable or available at the decoder. Finally, the paper presents a practical image compression algorithm for facial images based on our concept that demonstrates the superior performance in the very-low-bit-rate regime.

  5. Novel indexes based on network structure to indicate financial market

    Science.gov (United States)

    Zhong, Tao; Peng, Qinke; Wang, Xiao; Zhang, Jing

    2016-02-01

    There have been various achievements to understand and to analyze the financial market by complex network model. However, current studies analyze the financial network model but seldom present quantified indexes to indicate or forecast the price action of market. In this paper, the stock market is modeled as a dynamic network, in which the vertices refer to listed companies and edges refer to their rank-based correlation based on price series. Characteristics of the network are analyzed and then novel indexes are introduced into market analysis, which are calculated from maximum and fully-connected subnets. The indexes are compared with existing ones and the results confirm that our indexes perform better to indicate the daily trend of market composite index in advance. Via investment simulation, the performance of our indexes is analyzed in detail. The results indicate that the dynamic complex network model could not only serve as a structural description of the financial market, but also work to predict the market and guide investment by indexes.

  6. Reconstructing Carotenoid-Based and Structural Coloration in Fossil Skin.

    Science.gov (United States)

    McNamara, Maria E; Orr, Patrick J; Kearns, Stuart L; Alcalá, Luis; Anadón, Pere; Peñalver, Enrique

    2016-04-25

    Evidence of original coloration in fossils provides insights into the visual communication strategies used by ancient animals and the functional evolution of coloration over time [1-7]. Hitherto, all reconstructions of the colors of reptile integument and the plumage of fossil birds and feathered dinosaurs have been of melanin-based coloration [1-6]. Extant animals also use other mechanisms for producing color [8], but these have not been identified in fossils. Here we report the first examples of carotenoid-based coloration in the fossil record, and of structural coloration in fossil integument. The fossil skin, from a 10 million-year-old colubrid snake from the Late Miocene Libros Lagerstätte (Teruel, Spain) [9, 10], preserves dermal pigment cells (chromatophores)-xanthophores, iridophores, and melanophores-in calcium phosphate. Comparison with chromatophore abundance and position in extant reptiles [11-15] indicates that the fossil snake was pale-colored in ventral regions; dorsal and lateral regions were green with brown-black and yellow-green transverse blotches. Such coloration most likely functioned in substrate matching and intraspecific signaling. Skin replicated in authigenic minerals is not uncommon in exceptionally preserved fossils [16, 17], and dermal pigment cells generate coloration in numerous reptile, amphibian, and fish taxa today [18]. Our discovery thus represents a new means by which to reconstruct the original coloration of exceptionally preserved fossil vertebrates. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Viabilidade econômica da inclusão de óleo de girassol em dieta à base de cana-de-açúcar para vacas em lactação

    Directory of Open Access Journals (Sweden)

    M.A. Lopes

    2014-06-01

    Full Text Available Objetivou-se avaliar a viabilidade econômica da produção de leite de vacas Holandês x Gir, pela inclusão de níveis crescentes de óleo de girassol (0,0; 1,5; 3,0 e 4,5% na matéria seca de dietas baseadas em cana-de-açúcar. Os dados utilizados no estudo foram obtidos de experimento realizado com 12 vacas Holandês x Gir, multíparas, com produção média de 18,2kg/dia de leite, distribuídas em três quadrados latinos 4 x 4, conforme a produção de leite, a ordem de lactação e o peso corpóreo. As dietas foram isoproteicas, fornecidas ad libitum na forma de mistura total (relação volumoso:concentrado de 60:40, base matéria seca, e os consumos das vacas determinados diariamente. As produções individuais diárias de leite foram registradas, e sua composição foi analisada quanto aos teores de gordura, proteína e ácidos graxos. A viabilidade econômica foi realizada considerando-se os preços dos ingredientes fornecidos e o consumo diário da dieta de cada tratamento. O benefício econômico foi obtido pela diferença entre a receita, com a venda do leite, e o custo com alimentação dos animais. O pagamento por qualidade foi estimado pela média de oito sistemas utilizados por empresas do ramo de laticínios, com base nos teores de gordura, proteína e no volume de leite. A dieta sem inclusão de OG foi a que proporcionou maior benefício econômico. A inclusão de OG nas dietas baseadas em cana-de-açúcar não foi viável, economicamente, devido aos gastos adicionais com OG e às penalizações resultantes da redução dos teores de proteína e de gordura do leite.

  8. Nuclear reactors project optimization based on neural network and genetic algorithm; Otimizacao em projetos de reatores nucleares baseada em rede neural e algoritmo genetico

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Claudio M.N.A. [Instituto de Engenharia Nuclear (IEN), Rio de Janeiro, RJ (Brazil); Schirru, Roberto; Martinez, Aquilino S. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia

    1997-12-01

    This work presents a prototype of a system for nuclear reactor core design optimization based on genetic algorithms and artificial neural networks. A neural network is modeled and trained in order to predict the flux and the neutron multiplication factor values based in the enrichment, network pitch and cladding thickness, with average error less than 2%. The values predicted by the neural network are used by a genetic algorithm in this heuristic search, guided by an objective function that rewards the high flux values and penalizes multiplication factors far from the required value. Associating the quick prediction - that may substitute the reactor physics calculation code - with the global optimization capacity of the genetic algorithm, it was obtained a quick and effective system for nuclear reactor core design optimization. (author). 11 refs., 8 figs., 3 tabs.

  9. Impact of direct seeding mulch-based cropping systems on soil nematodes in a long-term experiment in Madagascar Impacto do plantio direto com cobertura vegetal nos nematódeos edáficos em experimento de longa duração em Madagascar

    Directory of Open Access Journals (Sweden)

    Cécile Villenave

    2009-08-01

    Full Text Available The objective of this work was to assess the effects of conventional tillage and of different direct seeding mulch-based cropping systems (DMC on soil nematofauna characteristics. The long-term field experiment was carried out in the highlands of Madagascar on an andic Dystrustept soil. Soil samples were taken once a year during three successive years (14 to 16 years after installation of the treatments from a 0-5-cm soil layer of a conventional tillage system and of three kinds of DMC: direct seeding on mulch from rotation soybean-maize residues; direct seeding of maize-maize rotation on living mulch of silverleaf (Desmodium uncinatum; direct seeding of bean (Phaseolus vulgaris-soybean rotation on living mulch of kikuyu grass (Pennisetum clandestinum. The samples were compared with samples from natural fallows. The soil nematofauna, characterized by the abundance of different trophic groups and indices (MI, maturity index; EI and SI, enrichment and structure indices, allowed the discrimination of the different cropping systems. The different DMC treatments had a more complex soil food web than the tillage treatment: SI and MI were significantly greater in DMC systems. Moreover, DMC with dead mulch had a lower density of free-living nematodes than DMC with living mulch, which suggested a lower microbial activity.O objetivo deste trabalho foi avaliar os efeitos do plantio convencional e de diferentes sistemas de plantio direto com cobertura vegetal (DMC nas características da nematofauna edáfica. Foi intalado um experimento de longa duração nos platôs centrais de Madagascar em um Inceptisol ândico. O solo foi amostrado uma vez por ano durante três anos consecutivos (14 a 16 anos após a instalação dos tratamentos na camada de 0-5 cm do solo em plantio convencional e em três tipos de DMC: plantio direto sobre cobertura morta de resíduos da rotação soja-milho; plantio direto da sucessão milho-milho sobre cobertura viva de Desmodium

  10. Changes in suspension properties of structural modified montmorillonites Mudanças em propriedades de suspensões de montmorilonitas modificadas estruturalmente

    Directory of Open Access Journals (Sweden)

    C. Volzone

    2001-03-01

    Full Text Available Rheological changes were found in smectite (Wyoming- and Cheto-type montmorillonites suspensions after structural modifications. The effect of the particle size and Na+ exchange on the flow curves of 6% wt/wt suspensions of smectites with and without Na2CO3 were examined. Mineralogical, structural and physicochemical characteristics were studied by X-ray diffraction (XRD, infrared spectroscopy (IR, cationic exchange capacity (CEC, Mg2+, Al3+ determinations, particle size distribution and swelling index (SI. Grinding in an oscillating mill modified the particle sizes. The montmorillonite grain size and the structural disorder increased after larger grinding times. The grinding treatment modified the apparent viscosity and the yield stress of the montmorillonite suspensions. The homoionic Na Cheto-type montmorillonite with fine particle size (obtained by grinding increased the flow properties. Nevertheless, rheological properties were lower than those of suspensions of the Wyoming-type montmorillonite. Montmorillonite-types reacted differently with Na2CO3 additions and this behavior may be related to their structural composition. The Na2CO3 activation improved the flow properties of the original Wyoming-type montmorillonite and after 30 s grinding.Foram encontradas mudanças reológicas em suspensões de esmectitas (montmorillonitas tipos Wyoming e Cheto após modificações estruturais. Foi examinado o efeito do tamanho de partícula e troca de Na+ nas curvas de escoamento de suspensões de esmectitas 6% peso com e sem Na2CO3. As características mineralógicas, estructurais e físico-químicas foram estudadas por difração de raios X (DRX, espectroscopia no infravermelho (IV, capacidade de troca catiônica (CTC, determinações de Mg2+ e Al3+, de distribuição de tamanho de partículas e de índice de expansão (swelling index - SI. Moagem em moinho oscilatório modificou o tamanho das partículas. O tamanho de grão da montmorillonita e a

  11. Micromechanics based simulation of ductile fracture in structural steels

    Science.gov (United States)

    Yellavajjala, Ravi Kiran

    The broader aim of this research is to develop fundamental understanding of ductile fracture process in structural steels, propose robust computational models to quantify the associated damage, and provide numerical tools to simplify the implementation of these computational models into general finite element framework. Mechanical testing on different geometries of test specimens made of ASTM A992 steels is conducted to experimentally characterize the ductile fracture at different stress states under monotonic and ultra-low cycle fatigue (ULCF) loading. Scanning electron microscopy studies of the fractured surfaces is conducted to decipher the underlying microscopic damage mechanisms that cause fracture in ASTM A992 steels. Detailed micromechanical analyses for monotonic and cyclic loading are conducted to understand the influence of stress triaxiality and Lode parameter on the void growth phase of ductile fracture. Based on monotonic analyses, an uncoupled micromechanical void growth model is proposed to predict ductile fracture. This model is then incorporated in to finite element program as a weakly coupled model to simulate the loss of load carrying capacity in the post microvoid coalescence regime for high triaxialities. Based on the cyclic analyses, an uncoupled micromechanics based cyclic void growth model is developed to predict the ULCF life of ASTM A992 steels subjected to high stress triaxialities. Furthermore, a computational fracture locus for ASTM A992 steels is developed and incorporated in to finite element program as an uncoupled ductile fracture model. This model can be used to predict the ductile fracture initiation under monotonic loading in a wide range of triaxiality and Lode parameters. Finally, a coupled microvoid elongation and dilation based continuum damage model is proposed, implemented, calibrated and validated. This model is capable of simulating the local softening caused by the various phases of ductile fracture process under

  12. Estimating material parameters of a structurally based constitutive relation for skin mechanics

    KAUST Repository

    Jor, Jessica W. Y.; Nash, Martyn P.; Nielsen, Poul M. F.; Hunter, Peter J.

    2010-01-01

    This paper presents a structurally based modeling framework to characterize the structure-function relation in skin tissues, based upon biaxial tensile experiments performed in vitro on porcine skin. Equi-axial deformations were imposed

  13. Pluralidade do nexo causal em acidente de trabalho/doença ocupacional: estudo de base legal no Brasil

    Directory of Open Access Journals (Sweden)

    Lenz Alberto Alves Cabral

    2018-02-01

    Full Text Available Resumo Introdução: a determinação do nexo causal do acidente de trabalho/doença ocupacional é de suma importância, pois sua análise envolve fatores ideológicos, éticos, humanísticos e legais, sendo realizada nos âmbitos trabalhista, previdenciário e cível. Objetivo: identificar e sistematizar atos normativos legais para subsidiar a compreensão interpretativa do nexo causal entre o sinistro laboral e o trabalho, nos âmbitos trabalhista, previdenciário e cível. Métodos: ensaio crítico-reflexivo, com base em levantamento e sistematização da legislação trabalhista brasileira que dá suporte ao estabelecimento do nexo causal no acidente do trabalho pelos atores sociais legalmente responsáveis por sua determinação. Resultados: são identificadas três modalidades de nexo causal: trabalhista, pelos Serviços Especializados de Engenharia de Segurança e Medicina do Trabalho (SESMT; previdenciário, pelo Instituto Nacional do Seguro Social (INSS; e cível, pela Justiça do Trabalho. A Lei nº 8.213/1991 é referência comum para as três instituições; outros atos legais normativos são específicos no âmbito de cada instituição: as Normas Regulamentadoras do Trabalho (SESMT; a Instrução Normativa 31 (INSS e o Código Civil (Justiça do Trabalho. Conclusão: o uso correto da legislação facilita o estabelecimento do elo entre o acidente e o trabalho, auxiliando na sua compreensão, padronização, diminuição de conflitos e aumento da notificação.

  14. STRUCTURED-LIGHT BASED 3D LASER SCANNING OF SEMI-SUBMERGED STRUCTURES

    Directory of Open Access Journals (Sweden)

    J. van der Lucht

    2018-05-01

    Full Text Available In this work we look at 3D acquisition of semi-submerged structures with a triangulation based underwater laser scanning system. The motivation is that we want to simultaneously capture data above and below water to create a consistent model without any gaps. The employed structured light scanner consist of a machine vision camera and a green line laser. In order to reconstruct precise surface models of the object it is necessary to model and correct for the refraction of the laser line and camera rays at the water-air boundary. We derive a geometric model for the refraction at the air-water interface and propose a method for correcting the scans. Furthermore, we show how the water surface is directly estimated from sensor data. The approach is verified using scans captured with an industrial manipulator to achieve reproducible scanner trajectories with different incident angles. We show that the proposed method is effective for refractive correction and that it can be applied directly to the raw sensor data without requiring any external markers or targets.

  15. Structured-Light Based 3d Laser Scanning of Semi-Submerged Structures

    Science.gov (United States)

    van der Lucht, J.; Bleier, M.; Leutert, F.; Schilling, K.; Nüchter, A.

    2018-05-01

    In this work we look at 3D acquisition of semi-submerged structures with a triangulation based underwater laser scanning system. The motivation is that we want to simultaneously capture data above and below water to create a consistent model without any gaps. The employed structured light scanner consist of a machine vision camera and a green line laser. In order to reconstruct precise surface models of the object it is necessary to model and correct for the refraction of the laser line and camera rays at the water-air boundary. We derive a geometric model for the refraction at the air-water interface and propose a method for correcting the scans. Furthermore, we show how the water surface is directly estimated from sensor data. The approach is verified using scans captured with an industrial manipulator to achieve reproducible scanner trajectories with different incident angles. We show that the proposed method is effective for refractive correction and that it can be applied directly to the raw sensor data without requiring any external markers or targets.

  16. Toward the Establishment of Standardized <em>In Vitroem> Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase

    DEFF Research Database (Denmark)

    Bakala-N'Goma, Jean-Claude; Williams, Hywel D.; Sassene, Philip J.

    2015-01-01

    Purpose Lipid-based formulations (LBF) are substrates for digestive lipases and digestion can significantly alter their properties and potential to support drug absorption. LBFs have been widely examined for their behaviour in the presence of pancreatic enzymes. Here, the impact of gastric lipase...... on the digestion of representative formulations from the Lipid Formulation Classification System has been investigated. Methods The pHstat technique was used to measure the lipolysis by recombinant dog gastric lipase (rDGL) of eight LBFs containing either medium (MC) or long (LC) chain triglycerides and a range...

  17. Estruturação de cristais de gelo em soluções aquosas contendo solutos diversos Ice crystals structuring in water solutions containing different solutes

    Directory of Open Access Journals (Sweden)

    CLÉCIA SILVA CARNEIRO

    2000-02-01

    Full Text Available Existe uma grande demanda de conhecimentos na área de criopreservação de frutos tropicais com vistas a reduzir os danos celulares provocados por cristais de gelo durante o congelamento. O objetivo deste trabalho foi estudar a capacidade de estruturação de cristais de gelo. Soluções aquosas contendo arabinose, glicose, piridoxina, creatina, metionina, lisina e arginina, foram submetidas a congelamento lento em ar estático e as amostras resultantes examinadas por microscopia ótica sob luz polarizada. Os açúcares arabinose e glicose provocaram nos cristais de gelo estruturações que variaram de uma configuração hexagonal a uma arbórea, dentre outras. Vitaminas hidrossolúveis e compostos hidrofílicos ou hidrofóbicos favoreceram a formação de arranjamentos circulares filamentosos.There is a great demand for information about the cryopreservation of tropical fruits to reduce cell damage caused by ice crystals during freezing. The objective of this work was to study the structuring capacity of ice cristals. Water solutions having arabinose, glucose, pyridoxine, creatine, methionine, lysine and arginine were submitted to a slow freezing process and the resulting samples were examined under an optical microscope under polarized light. Sugars (arabinose and glucose caused a range of structures, from hexagonal to tree-like configurations, among others. Water soluble vitamins and hydrophilic or hydrophobic compounds favored the formation of needles arranged in a circular-type manner.

  18. Cryo-EM structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6 (TRPC6).

    Science.gov (United States)

    Azumaya, Caleigh M; Sierra-Valdez, Francisco; Cordero-Morales, Julio F; Nakagawa, Terunaga

    2018-05-11

    The kidney maintains the internal milieu by regulating the retention and excretion of proteins, ions, and small molecules. The glomerular podocyte forms the slit diaphragm of the ultrafiltration filter, whose damage leads to progressive kidney failure and focal segmental glomerulosclerosis (FSGS). The canonical transient receptor potential 6 (TRPC6) ion channel is expressed in the podocyte and mutations in its cytoplasmic domain cause FSGS in humans. In vitro evaluation of disease-causing mutations in TRPC6 has revealed that these genetic alterations result in abnormal ion channel gating. However, the mechanism whereby the cytoplasmic domain modulates TRPC6 function is largely unknown. Here we report a cryoEM structure of the cytoplasmic domain of murine TRPC6 at 3.8Å resolution. The cytoplasmic fold of TRPC6 is characterized by an inverted dome-like chamber pierced by four radial horizontal helices that converge into a vertical coiled-coil at the central axis. Unlike in other TRP channels, TRPC6 displays a unique domain swap that occurs at the junction of the horizontal helices and coiled-coil. Multiple FSGS mutations converge at the buried interface between the vertical coiled-coil and the ankyrin repeats, which form the dome, suggesting these regions are critical for allosteric gating modulation. This functionally critical interface is a potential target for drug design. Importantly, dysfunction in other family members leads to learning deficits (TRPC1/4/5) and ataxia (TRPC3). Our data provide a structural framework for the mechanistic investigation of the TRPC family. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.

  19. Identificação de áreas para recomposição florestal com base em princípios de ecologia de paisagem

    Directory of Open Access Journals (Sweden)

    Ferraz Sílvio Frosini de Barros

    2003-01-01

    Full Text Available O manejo de áreas florestais com base em princípios de ecologia da paisagem é uma tendência do setor florestal, que tem como proposta o gerenciamento integrado dos aspectos econômicos, sociais e ambientais da atividade produtiva, envolvendo decisões complexas que podem ser auxiliadas pelas técnicas de geoprocessamento. No presente trabalho objetivou-se o desenvolvimento de uma metodologia para aplicação dos conceitos de ecologia de paisagem no planejamento do uso da terra em áreas de reflorestamento, por meio da utilização de um sistema de informações geográficas. Para tal, utilizou-se como área de estudo uma fazenda de reflorestamento da International Paper do Brasil, tendo sido estabelecidos cinco critérios para determinação de áreas para recomposição: fertilidade dos solos, mata nativa existente, corpos d'água, declividade e suscetibilidade à erosão. Esses fatores foram analisados, empregando-se os recursos de decisão multicritérios, em ambiente SIG. Como resultado foi obtido um mapa com áreas adequadas à recomposição florestal, segundo os critérios adotados. Com este mapa realizou-se uma simulação, alocando uma nova área de floresta nativa, e o resultado foi avaliado em nível de paisagem por meio de índices apropriados.

  20. Application of structural symmetries in the plane-wave-based transfer-matrix method for three-dimensional photonic crystal waveguides

    International Nuclear Information System (INIS)

    Li Zhiyuan; Ho Kaiming

    2003-01-01

    The plane-wave-based transfer-matrix method (TMM) exhibits a peculiar advantage of being capable of solving eigenmodes involved in an infinite photonic crystal and electromagnetic (EM) wave propagation in finite photonic crystal slabs or even semi-infinite photonic crystal structures within the same theoretical framework. In addition, this theoretical approach can achieve much improved numerical convergency in solution of photonic band structures than the conventional plane-wave expansion method. In this paper we employ this TMM in combination with a supercell technique to handle two important kinds of three-dimensional (3D) photonic crystal waveguide structures. The first one is waveguides created in a 3D layer-by-layer photonic crystal that possesses a complete band gap, the other more popular one is waveguides built in a two-dimensional photonic crystal slab. These waveguides usually have mirror-reflection symmetries in one or two directions perpendicular to their axis. We have taken advantage of these structural symmetries to reduce the numerical burden of the TMM solution of the guided modes. The solution to the EM problems under these mirror-reflection symmetries in both the real space and the plane-wave space is discussed in a systematic way and in great detail. Both the periodic boundary condition and the absorbing boundary condition are employed to investigate structures with or without complete 3D optical confinement. The fact that the EM field components investigated in the TMM are collinear with the symmetric axes of the waveguide brings great convenience and clarity in exploring the eigenmode symmetry in both the real space and the plane-wave space. The classification of symmetry involved in the guided modes can help people to better understand the coupling of the photonic crystal waveguides with external channels such as dielectric slab or wire waveguides

  1. Evaluation of <em>HER2em> Gene Amplification in Breast Cancer Using Nuclei Microarray <em>in em>S>itu em>Hybridization

    Directory of Open Access Journals (Sweden)

    Xuefeng Zhang

    2012-05-01

    Full Text Available Fluorescence<em> em>>in situ em>hybridization (FISH assay is considered the “gold standard” in evaluating <em>HER2/neu (HER2em> gene status. However, FISH detection is costly and time consuming. Thus, we established nuclei microarray with extracted intact nuclei from paraffin embedded breast cancer tissues for FISH detection. The nuclei microarray FISH (NMFISH technology serves as a useful platform for analyzing <em>HER2em> gene/chromosome 17 centromere ratio. We examined <em>HER2em> gene status in 152 cases of invasive ductal carcinomas of the breast that were resected surgically with FISH and NMFISH. <em>HER2em> gene amplification status was classified according to the guidelines of the American Society of Clinical Oncology and College of American Pathologists (ASCO/CAP. Comparison of the cut-off values for <em>HER2em>/chromosome 17 centromere copy number ratio obtained by NMFISH and FISH showed that there was almost perfect agreement between the two methods (κ coefficient 0.920. The results of the two methods were almost consistent for the evaluation of <em>HER2em> gene counts. The present study proved that NMFISH is comparable with FISH for evaluating <em>HER2em> gene status. The use of nuclei microarray technology is highly efficient, time and reagent conserving and inexpensive.

  2. Synthesis, Structure, Stability and Redispersion of Gold-based Nanoparticles

    Science.gov (United States)

    Tiruvalam, Ram Chandra

    Nanoscale gold has been shown to possess an intriguing combination of unexpected optical, photochemical and catalytic properties. The ability to control the size, shape, morphology, composition and dispersion of gold-based nanostructures is key to optimizing their performance for nanotechnology applications. The advanced electron microscopy studies described in this thesis analyze three important aspects of gold and gold-palladium alloy nanoparticles: namely, (i) the ability to synthesize gold nanoparticles of controlled size and shape in an aqueous medium; (ii) the colloidal preparation of designer gold-palladium alloys for selective oxidation catalysis; and (iii) the ability to disperse gold as finely and homogeneously as possible on a metal oxide or carbon support. The ability to exploit the nanoscale properties of gold for various engineering applications often depends on our ability to control size and shape of the nanoscale entity by careful manipulation of the synthesis parameters. We have explored an aqueous based synthesis route, using oleylamine as both a reductant and surfactant, for preparing gold nanostructures. By systematically varying synthesis parameters such as oleylamine concentration, reaction temperature, and aging time it is possible to identify processing regimens that generate Au nanostructures having either pseudo-spherical, faceted polyhedral, nanostar or wire shaped morphologies. Furthermore, by quenching the reaction partway through it is possible to create a class of metastable Au-containing structures such as nanocubes, nanoboxes and nanowires. Possible formation mechanisms for these gold based nano-objects are discussed. There is a growing interest in using supported bimetallic AuPd alloy nanoparticles for selective oxidation reactions. In this study, a systematic series of size controlled AuPd bimetallic particles have been prepared by colloidal synthesis methods. Particles having random alloy structures, as well as `designer

  3. Analysis of Plasmonics Based Fiber Optic Sensing Structures

    Science.gov (United States)

    Moayyed, Hamed

    The work described in this PhD Thesis focuses on the post-processing of optical fibers and their enhancement as sensing element. Since the majority of sensors presented are based in Fabry-Perot interferometers, an historical overview of this category of optical fiber sensors is firstly presented. This review considers the works published since the early years, in the beginning of the 1980s, until the middle of 2015. The incorporation of microcavities at the tip of a single mode fiber was extensively studied, particularly for the measurement of nitrogen and methane gas pressure. These cavities were fabricated using hollow core silica tubes and a hollow core photonic crystal fiber. Following a different approach, the microcavities were incorporated between two sections of single mode fiber. In this case, the low sensitivity to temperature makes these microcavities highly desirable for the measurement of strain at high temperatures. Competences in post-processing techniques such as the chemical etching and the writing of periodical structures in the fiber core by means of an excimer or a femtosecond laser were also acquired in the course of the PhD programme. One of the works consisted in the design and manufacturing of a double clad optical fiber. The refractive index of the inner cladding was higher than the one of the outer cladding and the core. Thus, light was guided in the inner cladding instead of propagating in the core. This situation was overcome by applying chemical etching, thus removing the inner cladding. The core, surrounded by air, was then able to guide light. Two different applications were found for this fiber, as a temperature sensor and as an optical refractometer. In the last, the optical phase changes with the liquid refractive index. Two different types of fiber Bragg gratings were characterized in strain and temperature. Sensing structures obtained through the phase mask technique at the tip of an optical fiber were subjected to chemical

  4. Financiamento e diversidade produtiva: um modelo baseado em agentes com flutuações cíclicas emergentes Financing and productive diversity: an agent-based model with emergent cyclic fluctuations

    Directory of Open Access Journals (Sweden)

    Teófilo Henrique Pereira de Paula

    2013-04-01

    Full Text Available As abordagens que consideram os choques externos como causa principal das flutuações econômicas têm dominado o debate sobre o tema. De fato, a ideia de que instabilidades podem se originar endogenamente sempre esbarrou em dificuldades de formalização ao pressupor a existência de processos não lineares e cumulativos como intrínsecos ao sistema econômico. Recentemente, a utilização de ferramentas computacionais tem permitido a superação de muitos desses obstáculos. Nessa perspectiva, o presente trabalho tem como objetivo analisar o comportamento agregado de um sistema econômico caracterizado pela interação entre unidades individuais heterogêneas que tomam decisões de forma descentralizada em um ambiente incerto. A metodologia utilizada se baseia na construção e na implementação computacional de um modelo de simulação baseado em agentes (agent-based model. Particularmente, uma estrutura industrial com diferenciação assimétrica de produtos é conectada a um sistema financeiro por meio do mercado de crédito. Dentre os principais resultados, crises financeiras com características bastante próximas daquelas descritas por Minsky emergem da evolução do sistema.External shocks as the major cause of economic fluctuations have dominated the debate in economic theory. In fact, propositions based on endogenous explanation of instabilities always found difficulties in formalization, basically by considering nonlinearities and cumulativeness as intrinsic characteristics of the economic system. Recently, however, the use of computational tools has increasingly allowed overcoming these obstacles. In this context, the paper aims at analyzing the aggregate behavior of an economic system characterized by interaction between heterogeneous agents, which take decisions in a decentralized way and subject to uncertainty. The methodology is based on construction and computational implementation of an agent-based model. Specifically, an

  5. Sobrevivencia de Salmonella enteritidis em ovos artificialmente contaminados e submetidos a diferentes tipos de cocção e em alimentos preparados a base de ovos e consumidos sem tratamento termico

    OpenAIRE

    Magaly Ananias Afonso

    1994-01-01

    Resumo: Determinou-se a sobrevivência de Salmonella enteritidis em ovos artificialmente, contaminados e submetidos à cocção em chama de gás e forno de microondas (FMO), e, em alimentos preparados com ovos contaminados c submetidos a diferentes temperaturas de armazenagem. Foi utilizado Salmonella enteritidis patogênico, fagotipo 28 isolado de aves e ovos brancos de galinhas comerciais. Os alimentos contaminados com aproximadamente 106 a 108 UFC e examinados foram: ovos cozidos em água ...

  6. Carbody structural lightweighting based on implicit parameterized model

    Science.gov (United States)

    Chen, Xin; Ma, Fangwu; Wang, Dengfeng; Xie, Chen

    2014-05-01

    Most of recent research on carbody lightweighting has focused on substitute material and new processing technologies rather than structures. However, new materials and processing techniques inevitably lead to higher costs. Also, material substitution and processing lightweighting have to be realized through body structural profiles and locations. In the huge conventional workload of lightweight optimization, model modifications involve heavy manual work, and it always leads to a large number of iteration calculations. As a new technique in carbody lightweighting, the implicit parameterization is used to optimize the carbody structure to improve the materials utilization rate in this paper. The implicit parameterized structural modeling enables the use of automatic modification and rapid multidisciplinary design optimization (MDO) in carbody structure, which is impossible in the traditional structure finite element method (FEM) without parameterization. The structural SFE parameterized model is built in accordance with the car structural FE model in concept development stage, and it is validated by some structural performance data. The validated SFE structural parameterized model can be used to generate rapidly and automatically FE model and evaluate different design variables group in the integrated MDO loop. The lightweighting result of body-in-white (BIW) after the optimization rounds reveals that the implicit parameterized model makes automatic MDO feasible and can significantly improve the computational efficiency of carbody structural lightweighting. This paper proposes the integrated method of implicit parameterized model and MDO, which has the obvious practical advantage and industrial significance in the carbody structural lightweighting design.

  7. Avaliação em curto e médio prazo da sorção e da solubilidade de resinas compostas à base de metacrilato e de silorano em saliva artificial

    Directory of Open Access Journals (Sweden)

    Isabel Cristina Celerino de Moraes Porto

    Full Text Available INTRODUÇÃO: A absorção/adsorção de moléculas de água por monômeros hidrofílicos dentro de materiais resinosos expostos à umidade da boca pode resultar em degradação. OBJETIVO: Este estudo avaliou sorção e solubilidade de resinas compostas à base de metacrilato e silorano em contato com saliva artificial, nos períodos de um dia (curto prazo, e 30 e 90 dias (médio prazo. MATERIAL E MÉTODO: Sessenta corpos de prova foram confeccionados com as resinas Filtek® Z250 e Filtek® P90 Silorano (3M/ESPE, e depois imersos em saliva artificial a 37 ± 1 ºC durante um, 30 e 90 dias. Os dados foram analisados usando-se ANOVA um fator/dois fatores seguido dos testes Tukey ou Tamhane (α = 0,05. RESULTADO: As médias de sorção das duas resinas aumentaram com o tempo (p = 0,001. A sorção de Z250 (1 e 90 d foi significativamente maior do que de P90 (p = 0,008, com valores semelhantes após 30 dias. A solubilidade das resinas também aumentou com o tempo, com diferença significativa entre todos os períodos (p = 0,001, exceto para a resina P90 (entre 1 e 30 d. Não houve diferença estatística significante entre os grupos Z250 (1 d e P90 (1 dia, Z250 (1 d e P90 (30 d, e Z250 (30 d e P90 (90 d. Para os demais pares, comprovaram-se diferenças significativas (p < 0,001. CONCLUSÃO: As propriedades de sorção e solubilidade das resinas compostas testadas foram influenciadas pelo tempo de exposição à saliva artificial. O silorano teve desempenho ora melhor ora semelhante à resina de metacrilato.

  8. Dinâmica da estrutura fitossociológica da regeneração natural em sub-bosque de Mimosa scabrella Bentham em área minerada, em Poços de Caldas, MG Phytosociology structure dynamics of natural regeneration in understory of Mimosa scabrella Bentham in mined area, Poços de Caldas, Brazil

    Directory of Open Access Journals (Sweden)

    Mauro Eloi Nappo

    2004-12-01

    Full Text Available Como estratégia de reabilitação de área minerada foram realizados, no ano agrícola 1982/1983, hidrossemeadura de gramíneas e leguminosa e o plantio puro de Mimosa scabrella Bentham em Poços de Caldas, MG. Em 1997 foi implantado um conjunto de 19 parcelas permanentes de 50 m² nessa área, para caracterização inicial do processo de regeneração natural. Em 2000, foi realizado o segundo inventário nas parcelas, para caracterização do processo de dinâmica da regeneração natural, que é o objeto deste trabalho. O processo de dinâmica da regeneração natural foi caracterizado mediante análises quantitativas e qualitativas da composição florística e da estrutura horizontal e vertical. O povoamento florestal do Retiro-Branco está sobre intensa atividade de estruturação, caracterizando o estágio inicial do processo de sucessão. O declínio do povoamento puro de Mimosa escabrella está modificando a ordem anteriormente estabelecida para o processo de sucessão da área, provocando a diversificação de condições de sítio e, assim, selecionando a ocupação deste em função dos grupos ecológicos, sendo as espécies pioneiras as mais favorecidas. As espécies secundárias são as de maior dominância nas maiores classes de altura e de diâmetro, sendo as principais responsáveis pela edificação do estrato superior, em especial a espécie Miconia sellowiana. As espécies que apresentaram melhor desempenho na colonização e estruturação da regeneração natural do Retiro-Branco, nos dois inventários, foram Miconia sellowiana, Psychotria sessilis, Leandra melastomoides, Clethra scabra, Myrsine umbellata, Miconia pepericarpa, Tibouchina candolleana, Cordia superba, Cestrum amictum, Alchornea triplinervia, Casearia sylvestris, Blepharocalyx salicifolius, Myrcia rostrata e Schinus terebinthifolius, sendo indicadas como espécies para uso nos programas de reabilitação de áreas mineradas em condições semelhantes sobre a

  9. Controlling nosocomial infection based on structure of hospital social networks.

    Science.gov (United States)

    Ueno, Taro; Masuda, Naoki

    2008-10-07

    Nosocomial infection (i.e. infection in healthcare facilities) raises a serious public health problem, as implied by the existence of pathogens characteristic to healthcare facilities such as methicillin-resistant Staphylococcus aureus and hospital-mediated outbreaks of influenza and severe acute respiratory syndrome. For general communities, epidemic modeling based on social networks is being recognized as a useful tool. However, disease propagation may occur in a healthcare facility in a manner different from that in a urban community setting due to different network architecture. We simulate stochastic susceptible-infected-recovered dynamics on social networks, which are based on observations in a hospital in Tokyo, to explore effective containment strategies against nosocomial infection. The observed social networks in the hospital have hierarchical and modular structure in which dense substructure such as departments, wards, and rooms, are globally but only loosely connected, and do not reveal extremely right-skewed distributions of the number of contacts per individual. We show that healthcare workers, particularly medical doctors, are main vectors (i.e. transmitters) of diseases on these networks. Intervention methods that restrict interaction between medical doctors and their visits to different wards shrink the final epidemic size more than intervention methods that directly protect patients, such as isolating patients in single rooms. By the same token, vaccinating doctors with priority rather than patients or nurses is more effective. Finally, vaccinating individuals with large betweenness centrality (frequency of mediating connection between pairs of individuals along the shortest paths) is superior to vaccinating ones with large connectedness to others or randomly chosen individuals, which was suggested by previous model studies.

  10. Mortalidade infantil em duas coortes de base populacional no Sul do Brasil: tendências e diferenciais

    Directory of Open Access Journals (Sweden)

    Menezes Ana M. B.

    1996-01-01

    Full Text Available Estudou-se a tendência temporal da mortalidade infantil através de dois estudos de coorte realizados em Pelotas, Rio Grande do Sul, em 1982 e 1993. Ambas coortes incluíram todos os nascimentos hospitalares e óbitos verificados através de visitas regulares aos hospitais, cartórios e cemitérios. As informações sobre a causa de morte foram obtidas através de entrevistas com pediatras, revisão do prontuário, necrópsias e entrevista com os pais das crianças. O coeficiente de mortalidade infantil caiu de 36,4 por mil nascidos vivos para 21,1 na década. As principais causas de mortalidade infantil em 1993 foram as perinatais, malformações congênitas, diarréia e infecções respiratórias. Crianças com baixo peso ao nascer apresentaram mortalidade 12 vezes maior do que crianças com peso adequado, e crianças pré-termo, duas vezes mais do que crianças com retardo de crescimento intra-uterino. Crianças de famílias com renda baixa (um salário mínimo apresentaram mortalidade sete vezes superior àquelas com renda alta (10 salários mínimos. A mortalidade de crianças de baixo peso ao nascer e alta renda familiar decresceu em 67%, contra apenas 36% para as de baixa renda. Conclui-se que, mesmo com uma queda expressiva da mortalidade infantil na década, persistem importantes desigualdades sociais.

  11. Estrutura e organização do trabalho infantil em situação de rua em Belo Horizonte, MG, Brasil Structure and organization of children's work on the streets in Belo Horizonte, MG, Brazil

    Directory of Open Access Journals (Sweden)

    Maria Núbia Alves Cruz

    2008-03-01

    Full Text Available Este artigo analisa a estrutura e as práticas de trabalho infantil em situação de rua, focalizando as estratégias e o papel das famílias. O método utilizado combina técnicas de observação da atividade, entrevistas simultâneas e entrevistas fora do local da atividade. As categorias de interesse para responder à hipótese do estudo foram organizadas, classificadas e analisadas por meio de cartas temáticas. Os resultados mostram a influência das famílias e da comunidade na execução das atividades e a mobilização de estratégias, visando alcançar os objetivos de trabalho. Esse comportamento expressa a aceitação e a participação familiar e da sociedade na estruturação do trabalho infantil. Porém a exposição à violência não é minimizada pela participação dos genitores, tampouco pela constituição de uma suposta rede de solidariedade. Não se vislumbram possibilidades educativas, dadas as condições de trabalho, incompatíveis com a idade dos sujeitos.This article analyses the organization and work practices of subjects enrolled in public programs of income transfer, focusing on the strategies developed and on the role of families in placing children and adolescents in street jobs. The qualitative method that was used applied activity observation techniques combined with simultaneous and outside work interviews. Narrative analysis was used based on categories of interest defined to answer the study hypothesis. The results show that there is a direct influence of families and the community on the performance of the activities and that the groups mobilize strategies to achieve their aims. This behavior expresses that the family and society accept and participate in the organization of children's work on the street. However, exposure to violence is not diminished by parents' participation nor by the constitution of a supposed solidarity network. Educational possibilities are not anticipated due to the work conditions

  12. A Receiver for Differential Space-Time -Shifted BPSK Modulation Based on Scalar-MSDD and the EM Algorithm

    Directory of Open Access Journals (Sweden)

    Kim Jae H

    2005-01-01

    Full Text Available In this paper, we consider the issue of blind detection of Alamouti-type differential space-time (ST modulation in static Rayleigh fading channels. We focus our attention on a -shifted BPSK constellation, introducing a novel transformation to the received signal such that this binary ST modulation, which has a second-order transmit diversity, is equivalent to QPSK modulation with second-order receive diversity. This equivalent representation allows us to apply a low-complexity detection technique specifically designed for receive diversity, namely, scalar multiple-symbol differential detection (MSDD. To further increase receiver performance, we apply an iterative expectation-maximization (EM algorithm which performs joint channel estimation and sequence detection. This algorithm uses minimum mean square estimation to obtain channel estimates and the maximum-likelihood principle to detect the transmitted sequence, followed by differential decoding. With receiver complexity proportional to the observation window length, our receiver can achieve the performance of a coherent maximal ratio combining receiver (with differential decoding in as few as a single EM receiver iteration, provided that the window size of the initial MSDD is sufficiently long. To further demonstrate that the MSDD is a vital part of this receiver setup, we show that an initial ST conventional differential detector would lead to strange convergence behavior in the EM algorithm.

  13. Electronic structure of nitride-based quantum dots

    Energy Technology Data Exchange (ETDEWEB)

    Winkelnkemper, Momme

    2008-11-07

    In the present work the electronic and optical properties of In{sub x}Ga{sub 1-x}N/GaN and GaN/AlN QDs are studied by means of eight-band k.p theory. Experimental results are interpreted in detail using the theoretical results. The k.p model for the QD electronicstructure calculations accounts for strain, piezo- and pyroelectric effects, spin-orbit and crystal-field splitting, and is implemented for arbitrarily shaped QDs on a finite differences grid. Few-particle corrections are included using the self-consistent Hartree method. Band parameters for the wurtzite and zinc-blende phases of GaN, AlN, and InN are derived from first-principle G{sub 0}W{sub 0} band-structure calculations. Reliable values are also provided for parameters that have not been determined experimentally yet. The electronic properties of nitride QDs are dominated by the large built-in piezo- and pyroelectric fields, which lead to a pronounced red-shift of excitonic transition energies and extremely long radiative lifetimes in large GaN/AlN QDs. In In{sub x}Ga{sub 1-x}N/GaN QDs these fields induce a pronounced dependence of the radiative excitonic lifetimes on the exact QD shape and composition. It is demonstrated that the resulting variations of the radiative lifetimes in an inhomogeneous QD ensemble are the origin of the multi-exponential luminescence decay frequently observed in time-resolved ensemble measurements on In{sub x}Ga{sub 1-x}N/GaN QDs. A polarization mechanism in nitride QDs based on strain-induced valence-band mixing effects is discovered. Due to the valence-band structure of wurtzite group-III nitrides and the specific strain situation in c-plane QDs, the confined hole states are formed predominantly by the two highest valence bands. In particular, the hole ground state (h{sub 0} {identical_to} h{sub A}) is formed by the A band, and the first excited hole state (h{sub 1} {identical_to} h{sub B}) by the B band. It is shown that the interband transitions involving h{sub A} or h

  14. Cost structure of and competition for forest-based biomass

    International Nuclear Information System (INIS)

    Lundmark, Robert

    2007-01-01

    Biomass has become a popular alternative to satisfy expanding energy demand and as a substitute for fossil fuels and phased-out nuclear energy in Europe. The European Union White Paper stipulates that the utilization of biomass shall increase to 1566 TWh by 2010. However it is often overlooked that the forest resources are already, to a large extent, used by the forest industries. When promoting biomass for energy generation the consequences for the forest industries also need to be considered. Sweden is an excellent case study, as there are vast quantities of forest resources, nuclear power is starting to be phased out, there are restrictions on expanding hydropower and the political desire exists to 'set an example' with respect to carbon dioxide emissions. This paper attempts to estimate and analyse the supply of two types of forest resource, namely, roundwood and harvesting residues derived from final harvesting and commercial thinnings. Two separate supply curves are estimated: one for roundwood and one for harvesting residues. The cost structure is based on an economic-engineering approach where the separate cost components are constructed from the lowest cost element into aggregates for labour, capital, materials and overhead costs for each forest resource. The results indicate an unutilized economic supply of 12 TWh of harvesting residues in Sweden. However, after these 12 TWh have been recovered it becomes more profitable to use roundwood for energy purposes than to continue extracting further amounts of harvesting residues

  15. Pyrometer model based on sensor physical structure and thermal operation

    International Nuclear Information System (INIS)

    Sebastian, Eduardo; Armiens, Carlos; Gomez-Elvira, Javier

    2010-01-01

    This paper proposes a new simplified thermal model for pyrometers, which takes into account both their internal and external physical structure and operation. The model is experimentally tested on the REMS GTS, an instrument for measuring ground temperature, which is part of the payload of the NASA MSL mission to Mars. The proposed model is based on an energy balance equation that represents the heat fluxes exchanged between sensor elements through radiation, conduction and convection. Despite being mathematically more complex than the more commonly used model, the proposed model makes it possible to design a methodology to compensate the effects of sensor spatial thermal gradients. The paper includes a practical methodology for identifying model constants, which is part of the GTS instrument calibration plan and uses a differential approach to avoid setup errors. Experimental results of the model identification methodology and a target temperature measurement performance after identification has been made are reported. Results demonstrate the good behaviour of the model, with errors below 0.15 deg. C in target temperature estimates.

  16. An ISVD-based Euclidian structure from motion for smartphones

    Science.gov (United States)

    Masiero, A.; Guarnieri, A.; Vettore, A.; Pirotti, F.

    2014-06-01

    The development of Mobile Mapping systems over the last decades allowed to quickly collect georeferenced spatial measurements by means of sensors mounted on mobile vehicles. Despite the large number of applications that can potentially take advantage of such systems, because of their cost their use is currently typically limited to certain specialized organizations, companies, and Universities. However, the recent worldwide diffusion of powerful mobile devices typically embedded with GPS, Inertial Navigation System (INS), and imaging sensors is enabling the development of small and compact mobile mapping systems. More specifically, this paper considers the development of a 3D reconstruction system based on photogrammetry methods for smartphones (or other similar mobile devices). The limited computational resources available in such systems and the users' request for real time reconstructions impose very stringent requirements on the computational burden of the 3D reconstruction procedure. This work takes advantage of certain recently developed mathematical tools (incremental singular value decomposition) and of photogrammetry techniques (structure from motion, Tomasi-Kanade factorization) to access very computationally efficient Euclidian 3D reconstruction of the scene. Furthermore, thanks to the presence of instrumentation for localization embedded in the device, the obtained 3D reconstruction can be properly georeferenced.

  17. Reference Gene Selection in the Desert Plant <em>Eremosparton songoricuem>m>

    Directory of Open Access Journals (Sweden)

    Dao-Yuan Zhang

    2012-06-01

    Full Text Available <em>Eremosparton songoricum em>(Litv. Vass. (<em>E. songoricumem> is a rare and extremely drought-tolerant desert plant that holds promise as a model organism for the identification of genes associated with water deficit stress. Here, we cloned and evaluated the expression of eight candidate reference genes using quantitative real-time reverse transcriptase polymerase chain reactions. The expression of these candidate reference genes was analyzed in a diverse set of 20 samples including various <em>E. songoricumem> plant tissues exposed to multiple environmental stresses. GeNorm analysis indicated that expression stability varied between the reference genes in the different experimental conditions, but the two most stable reference genes were sufficient for normalization in most conditions.<em> EsEFem> and <em>Esα-TUB> were sufficient for various stress conditions, <em>EsEF> and <em>EsACT> were suitable for samples of differing germination stages, and <em>EsGAPDH>and <em>Es>UBQ em>were most stable across multiple adult tissue samples. The <em>Es18Sem> gene was unsuitable as a reference gene in our analysis. In addition, the expression level of the drought-stress related transcription factor <em>EsDREB2em>> em>verified the utility of<em> E. songoricumem> reference genes and indicated that no single gene was adequate for normalization on its own. This is the first systematic report on the selection of reference genes in <em>E. songoricumem>, and these data will facilitate future work on gene expression in this species.

  18. Auto-percepções em adolescentes : uma intervenção com base na análise de letras musicais

    OpenAIRE

    Santos, Inês Martins dos

    2014-01-01

    Tese de mestrado, Psicologia (Secção de Psicologia Clínica e da Saúde - Núcleo de Psicoterapia Cognitiva-Comportamental e Integrativa), Universidade de Lisboa, Faculdade de Psicologia, 2014 O presente trabalho teve como principal objectivo a exploração de letras musicais como método com potencial para alterar as auto-percepções, analisando o potencial de criação de programas de intervenção com base na análise de letras musicais para aplicar em escolas ou instituições de forma a promover co...

  19. Fatores de Influência no Processo de Inovação em Empresas de Base Tecnológica = Influence Factors in the Innovation Process Technology Based Companies

    Directory of Open Access Journals (Sweden)

    Aléssio Bessa Sarquis

    2015-12-01

    Full Text Available A inovação é uma estratégia fundamental no setor de base tecnológica. O processo de gestão é influenciado por diferentes fatores do ambiente interno e externo da organização. Assim, o presente estudo buscou analisar os fatores de influência no processo de inovação nas empresas de base tecnológica do Polo Tecnológico de Florianópolis/SC. A coleta de dados primários envolveu a aplicação de pesquisa quantitativa, descritiva não conclusiva, na forma de levantamento de campo (survey, de corte transversal, em 96 empresas de base tecnológica, por meio de questionário autoadministrado e pré-testado. Os resultados apontaram como principais fatores de influência os seguintes: disponibilidade de recursos financeiros/tecnológicos externos; apoio de governo, agências de fomento e associações empresariais; participação de clientes e técnicos externos (fatores do ambiente externo; existência de processo de inovação estruturado; disponibilidade de recursos internos; cultura organizacional favorável à inovação (fatores do ambiente interno.Innovation is a key strategy in technology-based industry, and the management process influenced by different factors of the internal and external environment of the organization. The present study investigates the influence of factors in the innovation process in technology-based companies in the Technological Pole of Florianópolis/SC. The primary data collection involved the application of quantitative research, no conclusive descriptive, in the form of survey, cross-sectional in 96 technology-based companies, through self-administered questionnaire and pre-tested. The results showed the following main influencing factors: availability of financial resources and external technology; support of government, development agencies and business associations; participation of customers and external experts (the external environment factors; existence of structured innovation process

  20. Structure-based inference of molecular functions of proteins of unknown function from Berkeley Structural Genomics Center

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung-Hou; Shin, Dong Hae; Hou, Jingtong; Chandonia, John-Marc; Das, Debanu; Choi, In-Geol; Kim, Rosalind; Kim, Sung-Hou

    2007-09-02

    Advances in sequence genomics have resulted in an accumulation of a huge number of protein sequences derived from genome sequences. However, the functions of a large portion of them cannot be inferred based on the current methods of sequence homology detection to proteins of known functions. Three-dimensional structure can have an important impact in providing inference of molecular function (physical and chemical function) of a protein of unknown function. Structural genomics centers worldwide have been determining many 3-D structures of the proteins of unknown functions, and possible molecular functions of them have been inferred based on their structures. Combined with bioinformatics and enzymatic assay tools, the successful acceleration of the process of protein structure determination through high throughput pipelines enables the rapid functional annotation of a large fraction of hypothetical proteins. We present a brief summary of the process we used at the Berkeley Structural Genomics Center to infer molecular functions of proteins of unknown function.

  1. Metamaterial based embedded acoustic filters for structural applications

    Directory of Open Access Journals (Sweden)

    Hongfei Zhu

    2013-09-01

    Full Text Available We investigate the use of acoustic metamaterials to design structural materials with frequency selective characteristics. By exploiting the properties of acoustic metamaterials, we tailor the propagation characteristics of the host structure to effectively filter the constitutive harmonics of an incoming broadband excitation. The design approach exploits the characteristics of acoustic waveguides coupled by cavity modes. By properly designing the cavity we can tune the corresponding resonant mode and, therefore, coupling the waveguide at a prescribed frequency. This structural design can open new directions to develop broadband passive vibrations and noise control systems fully integrated in structural components.

  2. Stochastic Finite Elements in Reliability-Based Structural Optimization

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Engelund, S.

    1995-01-01

    Application of stochastic finite elements in structural optimization is considered. It is shown how stochastic fields modelling e.g. the modulus of elasticity can be discretized in stochastic variables and how a sensitivity analysis of the reliability of a structural system with respect to optimi......Application of stochastic finite elements in structural optimization is considered. It is shown how stochastic fields modelling e.g. the modulus of elasticity can be discretized in stochastic variables and how a sensitivity analysis of the reliability of a structural system with respect...... to optimization variables can be performed. A computer implementation is described and an illustrative example is given....

  3. Fingerprint-based structure retrieval using electron density.

    Science.gov (United States)

    Yin, Shuangye; Dokholyan, Nikolay V

    2011-03-01

    We present a computational approach that can quickly search a large protein structural database to identify structures that fit a given electron density, such as determined by cryo-electron microscopy. We use geometric invariants (fingerprints) constructed using 3D Zernike moments to describe the electron density, and reduce the problem of fitting of the structure to the electron density to simple fingerprint comparison. Using this approach, we are able to screen the entire Protein Data Bank and identify structures that fit two experimental electron densities determined by cryo-electron microscopy. Copyright © 2010 Wiley-Liss, Inc.

  4. Stochastic Finite Elements in Reliability-Based Structural Optimization

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Engelund, S.

    Application of stochastic finite elements in structural optimization is considered. It is shown how stochastic fields modelling e.g. the modulus of elasticity can be discretized in stochastic variables and how a sensitivity analysis of the reliability of a structural system with respect to optimi......Application of stochastic finite elements in structural optimization is considered. It is shown how stochastic fields modelling e.g. the modulus of elasticity can be discretized in stochastic variables and how a sensitivity analysis of the reliability of a structural system with respect...

  5. Core@shell@shell structured carbon-based magnetic ternary nanohybrids: Synthesis and their enhanced microwave absorption properties

    Science.gov (United States)

    Yang, Erqi; Qi, Xiaosi; Xie, Ren; Bai, Zhongchen; Jiang, Yang; Qin, Shuijie; Zhong, Wei; Du, Youwei

    2018-05-01

    High encapsulation efficiency of core@shell@shell structured carbon-based magnetic ternary nanohybrids have been synthesized in high yield by chemical vapor deposition of acetylene directly over octahedral-shaped Fe2O3 nanoparticles. By controlling the pyrolysis temperature, Fe3O4@Fe3C@carbon nanotubes (CNTs) and Fe@Fe3C@CNTs ternary nanohybrids could be selectively produced. The optimal RL values for the as-prepared ternary nanohybrids could reach up to ca. -46.7, -52.7 and -29.5 dB, respectively. The excellent microwave absorption properties of the obtaiend ternary nanohybrids were proved to ascribe to the quarter-wavelength matching model. Moreover, the as-prepared Fe@Fe3C@CNTs ternary nanohybrids displayed remarkably enhanced EM wave absorption capabilities compared to Fe3O4@Fe3C@CNTs due to their excellent dielectric loss abilities, good complementarities between the dielectric loss and the magnetic loss, and high attenuation constant. Generally, this strategy can be extended to explore other categories of core@shell or core@shell@shell structured carbon-based nanohybrids, which is very beneficial to accelerate the advancements of high performance MAMs.

  6. Synthesis, structural, spectroscopic and biological studies of Schiff base complexes

    Science.gov (United States)

    Diab, M. A.; El-Sonbati, A. Z.; Shoair, A. F.; Eldesoky, A. M.; El-Far, N. M.

    2017-08-01

    Schiff base ligand 4-((pyridin-2- yl)methyleneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one (PDMP) and its complexes were prepared and characterized on the basis of elemental analysis, IR, mass spectra and thermogravimetric analysis. All results confirm that the complexes have 1:1 (M: PMDP) stoichiometric formula [M(PMDP)Cl2H2O ] (M = Cu(II), Co(II), Ni(II) and Mn(II)), [Cd(PMDP)Cl2] and the ligand behaves as a bi/tridentate forming five-membered chelating ring towards the metal ions, bonding through azomethine nitrogen/exocyclic carbonyl oxygen, azomethine pyridine nitrogen and exocyclic carbonyl oxygen. The shift in the band positions of the groups involved in coordination has been utilized to estimate the metal-nitrogen and/or oxygen bond lengths. The complexes of Co(II), Ni(II) and Cu(II) are paramagnetic and the magnetic as well as spectral data suggest octahedral geometry, whereas the Cd(II) complex is tetrahedral. The XRD studies show that both the ligand and its metal complexes (1 and 3) show polycrystalline with crystal structure. Molecular docking was used to predict the binding between PMDP ligand and the receptors. The corrosion inhibition of mild steel in 2 M HCl solution by PDMP was explored utilizing potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and (EFM) electrochemical frequency modulation method. Potentiodynamic polarization demonstrated that PDMP compound is mixed-type inhibitor. EIS spectra exhibit one capacitive loop and confirm the protective ability. The percentage of inhibition efficiency was found to increase with increasing the inhibitor concentration.

  7. Método da adsorção de césio para determinação da carga estrutural em solos altamente intemperizados Method of cesium adsorption for determination of structural charge in highly weathered soils

    Directory of Open Access Journals (Sweden)

    Oscarlina Lúcia dos Santos Weber

    2005-01-01

    Full Text Available O conhecimento das cargas elétricas, permanente e variável, é fundamental para a compreensão e previsão do destino de elementos químicos no solo. Foram investigadas propriedades de carga de superfície de dois Latossolos Vermelhos acriférricos, dois Latossolos Amarelos ácricos e um Nitossolo Vermelho eutroférrico, usado como referência, por apresentar carga predominantemente permanente. Essas amostras foram investigadas pelo método da adsorção do íon césio (Cs+, que mede a carga estrutural permanente (sigmaO. O método baseia-se na preferência de sítios siloxanos de superfície para Cs+ sobre Li+ e de grupos de superfície ionizáveis de menor seletividade ao íon Cs+. Nos Latossolos acriférricos, a carga permanente diminuiu à medida que o índice de intemperização (Ki diminuiu. O método da adsorção de césio quantificou significativa carga permanente, mesmo em solos altamente intemperizados.The knowledge of permanent and variable charge is of high importance to a better understanding of the fate of chemical elements in soil. Four Brazilian Oxisols presenting acric character were investigated by an ion adsorption method that measures the structural charge density (sigmaO and were compared to an Alfisol (NV, which had predominantly permanent charge. The method is based on the preference of siloxane surface sites for cesium over lithium and on the lower selectivity of ionizable surface group for the ion cesium. In the Acrudoxes, the permanent charge decreased as the weathering index (Ki decreased. The cesium adsorption method quantified significant amounts of structural charge, even in highly weathered soils.

  8. Modelo para a mensuração do capital intelectual: uma abordagem fundamentada em recursos A model for measuring intellectual capital: an approach centered on a resources-based view

    Directory of Open Access Journals (Sweden)

    Olivir Sebastião Malavski

    2010-09-01

    Full Text Available A compreensão dos mecanismos de criação de valor na produção de bens ou serviços tem ocupado um lugar especial na agenda das empresas. O renascimento da Teoria Baseada em Recursos é um sinal da intensificação desta busca, em que se procura identificar o papel dos recursos, capacitações e competências na criação de valor nos sistemas de operações. Este trabalho desenvolve um modelo fundamentado no conceito de capital intelectual para articular recursos, capacitações e competências organizacionais. O modelo é construído a partir das definições das variáveis recursos, capacitações, competências e capital intelectual, trabalhando esses elementos em seus diferentes níveis de análise. A estrutura utilizada para a construção do modelo de integração fundamenta-se no modelo do navegador Skandia, apropriando-se das suas dimensões de desempenho para fins de desenvolvimento deste trabalho. O resultado é um modelo que explica a dinâmica de integração de recursos, capacitações e competências para a avaliação da criação de valor na forma de capital intelectual.Understanding value creation mechanisms for producing goods and services occupies a special place in enterprises' agenda. The renaissance of Resource Based Theory is a sign of this research intensification, which is focused on organizational resources, capabilities and the role of competences in operations systems value creation. This work develops an integration model based on the intellectual capital concept, to articulate resources, capabilities and competences. The model is built using the resources, capabilities, competences and intellectual capital variables definition, addressing them in their different levels of analysis. The structure of the integration model construction used is based on the Skandia navigator model, taking into account their performance dimensions for developing this study. The result is a model that explains the integrative dynamics

  9. Feature-based motion control for near-repetitive structures

    NARCIS (Netherlands)

    Best, de J.J.T.H.

    2011-01-01

    In many manufacturing processes, production steps are carried out on repetitive structures which consist of identical features placed in a repetitive pattern. In the production of these repetitive structures one or more consecutive steps are carried out on the features to create the final product.

  10. NEW WEB-BASED ACCESS TO NUCLEAR STRUCTURE DATASETS.

    Energy Technology Data Exchange (ETDEWEB)

    WINCHELL,D.F.

    2004-09-26

    As part of an effort to migrate the National Nuclear Data Center (NNDC) databases to a relational platform, a new web interface has been developed for the dissemination of the nuclear structure datasets stored in the Evaluated Nuclear Structure Data File and Experimental Unevaluated Nuclear Data List.

  11. Coevolutionary and genetic algorithm based building spatial and structural design

    NARCIS (Netherlands)

    Hofmeyer, H.; Davila Delgado, J.M.

    2015-01-01

    In this article, two methods to develop and optimize accompanying building spatial and structural designs are compared. The first, a coevolutionary method, applies deterministic procedures, inspired by realistic design processes, to cyclically add a suitable structural design to the input of a

  12. X-ray structure based evaluation of analogs of citalopram

    DEFF Research Database (Denmark)

    Topiol, Sid; Bang-Andersen, Benny; Sanchez, Connie

    2017-01-01

    The recent publication of X-ray structures of SERT includes structures with the potent antidepressant S-Citalopram (S-Cit). Earlier predictions of ligand binding at both a primary (S1) and an allosteric modulator site (S2), were confirmed. We provide herein examples of a series of Citalopram anal...

  13. Prediction of Seismic Damage-Based Degradation in RC Structures

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Gupta, Vinay K.; Nielsen, Søren R.K.

    Estimation of structural damage from known increase in the fundamental period of a structure after an earthquake or prediction of degradation of stiffness and strength for known damage requires reliable correlations between these response functionals. This study proposes a modified Clough-Johnsto...

  14. Plasmon resonance optical tuning based on photosensitive composite structures

    DEFF Research Database (Denmark)

    Gilardi, Giovanni; Xiao, Sanshui; Mortensen, N. Asger

    2014-01-01

    This paper reports a numerical investigation of a periodic metallic structure sandwiched between two quartz plates. The volume comprised between the quartz plates and the metallic structure is infiltrated by a mixture of azo-dye-doped liquid crystal. The exposure to a low power visible light beam...

  15. Tensor based structure estimation in multi-channel images

    DEFF Research Database (Denmark)

    Schou, Jesper; Dierking, Wolfgang; Skriver, Henning

    2000-01-01

    . In the second part tensors are used for representing the structure information. This approach has the advantage, that tensors can be averaged either spatially or by applying several images, and the resulting tensor provides information of the average strength as well as orientation of the structure...

  16. UAV-based urban structural damage assessment using object-based image analysis and semantic reasoning

    Science.gov (United States)

    Fernandez Galarreta, J.; Kerle, N.; Gerke, M.

    2015-06-01

    Structural damage assessment is critical after disasters but remains a challenge. Many studies have explored the potential of remote sensing data, but limitations of vertical data persist. Oblique imagery has been identified as more useful, though the multi-angle imagery also adds a new dimension of complexity. This paper addresses damage assessment based on multi-perspective, overlapping, very high resolution oblique images obtained with unmanned aerial vehicles (UAVs). 3-D point-cloud assessment for the entire building is combined with detailed object-based image analysis (OBIA) of façades and roofs. This research focuses not on automatic damage assessment, but on creating a methodology that supports the often ambiguous classification of intermediate damage levels, aiming at producing comprehensive per-building damage scores. We identify completely damaged structures in the 3-D point cloud, and for all other cases provide the OBIA-based damage indicators to be used as auxiliary information by damage analysts. The results demonstrate the usability of the 3-D point-cloud data to identify major damage features. Also the UAV-derived and OBIA-processed oblique images are shown to be a suitable basis for the identification of detailed damage features on façades and roofs. Finally, we also demonstrate the possibility of aggregating the multi-perspective damage information at building level.

  17. Targeting Dengue Virus NS-3 Helicase by Ligand based Pharmacophore Modeling and Structure based Virtual Screening

    Science.gov (United States)

    Halim, Sobia A.; Khan, Shanza; Khan, Ajmal; Wadood, Abdul; Mabood, Fazal; Hussain, Javid; Al-Harrasi, Ahmed

    2017-10-01

    Dengue fever is an emerging public health concern, with several million viral infections occur annually, for which no effective therapy currently exist. Non-structural protein 3 (NS-3) Helicase encoded by the dengue virus (DENV) is considered as a potential drug target to design new and effective drugs against dengue. Helicase is involved in unwinding of dengue RNA. This study was conducted to design new NS-3 Helicase inhibitor by in silico ligand- and structure based approaches. Initially ligand-based pharmacophore model was generated that was used to screen a set of 1201474 compounds collected from ZINC Database. The compounds matched with the pharmacophore model were docked into the active site of NS-3 helicase. Based on docking scores and binding interactions, twenty five compounds are suggested to be potential inhibitors of NS3 Helicase. The pharmacokinetic properties of these hits were predicted. The selected hits revealed acceptable ADMET properties. This study identified potential inhibitors of NS-3 Helicase in silico, and can be helpful in the treatment of Dengue.

  18. Identification of <em>Colletotrichum> species causing anthracnose on Tahiti lime, tree tomato and mango

    Directory of Open Access Journals (Sweden)

    Martínez Erika P.

    2009-08-01

    Full Text Available

    In Colombia, citrus, tree tomato and mango crops are likely to suffer considerable losses from anthracnose caused by several <em>Colletotrichum> species, which were identified by the present study on infected organs of the three fruit crops, sampled in different regions of the country. Identification was based on their morphological and molecular characteristics, as well as on fungicide (benomyl and copper hydroxide sensitivity and pathogenicity tests. The latter assessed infectivity on both the original hosting crop and the other two crops (crossed infection, by putting the fungi in contact with organs taken from the three fruit crops. Molecular identification of the <em>Colletotrichum> species was carried out through amplification of rDNA ITS regions by means of <em>C. gloeosporioidesem> (CgInt and <em>C. acutatumem> (CaInt2 specific primer PCR combining the use of ITS4 universal primer. The results indicate that <em>C. acutatumem> is the infectious agent in Tahiti lime and tree tomato, and so is <em>C. gloeosporioidesem> in mango. Although <em>C. acutatumem> is the infectious agent in two diferent fruit species, the strains proved to be specific of their original hosts.

  19. Microclimatologia do Município de Sintra com base em estações meteorológicas

    OpenAIRE

    Domingos, Sónia Isabel Sequeira

    2008-01-01

    Tese de mestrado em Ciências Geofísicas (Meteorologia), apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2008 No âmbito do Plano Estratégico para o Concelho de Sintra face às alterações climáticas, celebrado entre a Câmara Municipal de Sintra e a Fundação da Faculdade de Ciências da Universidade de Lisboa (FFCUL) conhecido como projecto SIAM Sintra -, foi desenvolvido este trabalho com vista a caracterizar e obter representações quantitativas dos microclimas da reg...

  20. Dosagem de concreto ecológico com base em estudo de empacotamento de partículas

    OpenAIRE

    Londero, Carolina

    2016-01-01

    Orientador : Profª. Drª. Nayara Soares Klein Co-orientador : Prof. Dr. Wellington Mazer Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Tecnologia, Programa de Pós-Graduação em Construção Civil. Defesa: Curitiba, 29/04/2016 Inclui referências : f. 119-126 Area de concentração : Materiais e estruturas Resumo: As questões ambientais que envolvem a produção de concreto vêm sendo muito estudadas, uma vez que o consumo elevado de cimento Portland causa impactos amb...