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Sample records for em radioterapia conformal

  1. Algoritmo evolucionário para otimização do plano de tratamento em radioterapia conformal 3D

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    Marco César Goldbarg

    2009-08-01

    Full Text Available O planejamento do tratamento por radioterapia tem por objetivo atingir um volume alvo com altas doses de radiação tomando cuidado para não expor órgãos sadios a doses elevadas. É, portanto, muito importante que se encontre um balanço ideal entre esses objetivos conflitantes. O presente trabalho relata um modelo de programação matemática multiobjetivo e introduz um Algoritmo Transgenético para o problema de seleção do direcionamento dos feixes de radiação no planejamento em radioterapia conformal 3D. A seleção das direções dos feixes é feita através de uma técnica denominada de isocentros variáveis. Com a finalidade de testar o potencial do algoritmo desenvolvido, realiza-se um experimento comparativo com um Algoritmo Genético Multiobjetivo. O experimento computacional obtém dados quantitativos e qualitativos que são analisados no trabalho.The radiotherapy treatment planning aims to achieve a target volume with high doses of radiation taking care not to expose healthy organs to high doses. It is therefore very important to find an optimal balance between these conflicting goals. This paper reports a mathematical model of multiobjective programming and presents a Transgenetic Algorithm for the problem of selecting the direction of radiation beams in 3D conformal radiotherapy planning. The selection of beams directions is done with a technique called variable isocenters. In order to test the potential of the developed algorithm, a comparative experiment with a multiobjective genetic algorithm was done. The computational experiment obtains quantitative and qualitative data that are analyzed in this paper.

  2. Evaluation of homogeneity and dose conformity in IMRT planning in prostate radiotherapy; Avaliacao da homogeneidade e conformidade de dose em planejamentos de IMRT de prostata em radioterapia

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    Lopes, Juliane S.; Leidens, Matheus; Estacio, Daniela R., E-mail: juliane.lopes@pucrs.br [Hospital Sao Lucas (PUC-RS), Porto Alegre, RS (Brazil). Servico de Radioterapia; Razera, Ricardo A.Z.; Streck, Elaine E.; Silva, Ana M.M. da [Pontificia Universidade Catolica do Rio Grande do Sul (PUC-RS), Porto Alegre, RS (Brazil). Faculdade de Fisica

    2015-12-15

    The goal of this study was to evaluate the dose distribution homogeneity and conformity of radiation therapy plans of prostate cancer using IMRT. Data from 34 treatment plans of Hospital Sao Lucas of PUCRS, where those plans were executed, were retrospectively analyzed. All of them were done with 6MV X-rays from a linear accelerator CLINAC IX, and the prescription doses varied between 60 and 74 Gy. Analyses showing the homogeneity and conformity indices for the dose distribution of those plans were made. During these analyses, some comparisons with the traditional radiation therapy planning technic, the 3D-CRT, were discussed. The results showed that there is no correlation between the prescribed dose and the homogeneity and conformity indices, indicating that IMRT works very well even for higher doses. Furthermore, a comparison between the results obtained and the recommendations of ICRU 83 was carried out. It has also been observed that the indices were really close to the ideal values. 82.4% of the cases showed a difference below 5% of the ideal value for the index of conformity, and 88.2% showed a difference below 10% for the homogeneity index. Concluding, it is possible to confirm the quality of the analyzed radiation therapy plans of prostate cancer using IMRT. (author)

  3. Radioterapia em adenocarcinoma de pâncreas

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    WELTMAN EDUARDO

    2002-01-01

    Full Text Available OBJETIVO: Avaliar retrospectivamente a sobrevida dos pacientes portadores de adenocarcinoma de pâncreas tratados no Serviço de Radioterapia do Hospital Israelita Albert Einstein, comparando os resultados com a literatura, e apresentando proposta de conduta. MÉTODOS: Entre abril de 1993 e agosto de 1999, 40 pacientes com adenocarcinoma de pâncreas foram admitidos para radioterapia neste Serviço. Destes, 25 haviam sido submetidos a procedimento cirúrgico radical com ressecção do tumor e em 15 o tumor não havia sido ressecado (não operados, biopsiados apenas ou submetidos a intervenções cirúrgicas paliativas. RESULTADOS: A sobrevida actuarial mediana para toda amostra foi de 14,8 meses, sendo as probabilidades de sobrevida em 12 e 24 meses, 70% e 22,2%, respectivamente. A sobrevida actuarial mediana para o grupo de pacientes que tiveram o tumor ressecado foi de 21,4 meses e para o grupo de pacientes com tumor não ressecado, 16,1 meses, sendo a probabilidade de sobreviver 12 e 24 meses de 76% e 32% no primeiro grupo e 60% e 0% no segundo (p=0,0156. CONCLUSÕES: Os nossos resultados são semelhantes aos descritos na literatura médica atual. Há necessidade de introduzir novas drogas ativas para o tratamento destes tumores e a radioterapia intra-operatória tem que ser melhor explorada.

  4. Remodelagem do sistema computacional para dosimetria em radioterapia por nêutrons e fótons baseado em métodos estocásticos - SISCODES

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    Bruno Machado Trindade

    2011-01-01

    O presente trabalho apresenta a remodelagem do Sistema Computacional para Dosimetria em Radioterapia por Nêutrons e Fótons Baseado em Métodos Estocásticos . SISCODES. Para isso mostra a proposta inicial e estado anterior do sistema, as modificações e expansões propostas e executadas, e o estado atual de desenvolvimento do sistema. Melhorias futuras são propostas ao final do trabalho. O SISCODES é um sistema que permite a execução de planejamento computacional 3D em radioterapia, através de si...

  5. Radiological response and dosimetry in physical phantom of head and neck for 3D conformational radiotherapy; Resposta radiologica e dosimetria em phantom fisico de cabeca e pescoco para radioterapia conformacional 3D

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    Thompson, Larissa

    2013-07-01

    Phantoms are tools for simulation of organs and tissues of the human body in radiology and radiotherapy. This thesis describes the development, validation and, most importantly, the use of a physical head and neck phantom in radiology and radiotherapy, with the purpose of evaluating dose distribution using Gafchromic EBT2 film in 15 MV 3D conformal radiotherapy. The work was divided in two stages, (1) development of new equivalent tissues and improvement of the physical phantom, and (2) use of the physical phantom in experimental dosimetry studies. In phase (1) parameters such as mass density, chemical composition of tissues, anatomical and biometric measurements were considered, as well as aspects of imaging by computed tomography (CT) and radiological response representation in Hounsfield Units (HU), which were compared with human data. Radiological experiments of in-phantom simulated brain pathologies were also conducted. All those results matched human-sourced data, therefore the physical phantom is a suitable simulator that may be used to enhance radiological protocols and education in medical imaging. The main objective in phase (2) was to evaluate the spatial dose distribution in a brain tumor simulator inserted inside the head and neck phantom developed by the Ionizing Radiation Research Group (NRI), exposed to 15 MV 3D conformal radiotherapy, for internal dose assessment. Radiation planning was based on CT images of the physical phantom with a brain tumor simulator made with equivalent material. The treatment planning system (TPS), CAT3D software, used CT images and prescribed a dose of 200 cGy, distributed in three fields of radiation, in a T-shaped pattern. The TPS covered the planning treatment volume (PTV) with 97% of the prescribed dose. A solid water phantom and radiochromic Gafchromic EBT2 film were used for calibration procedures, generating a dose response curve as a function of optical density (OD). After calibration and irradiation, the film

  6. Peculiaridades da radioterapia em idosos Peculiarities of radiotherapy in the elderly

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    Michael Jenwei Chen

    2010-10-01

    Full Text Available É sabido que o envelhecimento da população do mundo durante o século XX e no início deste novo século constitui um desafio de primeira ordem para as nações, especialmente no campo socioeconômico. Um aspecto importante do envelhecimento populacional global é que, para grupos de idade mais avançada, a prevalência das doenças degenerativas também é maior, incluindo as doenças malignas. No universo de pacientes portadores de câncer, por outro lado, metade destes receberá radioterapia em algum momento de sua doença e suas características individuais podem influenciar, de alguma forma, o prognóstico, a indicação e as doses diárias de prescrição dos tratamentos. Neste contexto, a assistência à saúde do idoso portador de câncer deve ser vista como um importante desafio, principalmente devido a dois fatores: uma maior procura de tratamentos, em termos quantitativos, e características fisiológicas peculiares a esta população, que podem influenciar na tomada de decisões terapêuticas. Esta revisão propõe uma discussão sobre alguns aspectos relevantes tanto da fisiologia dos idosos, que pode influenciar o curso do tratamento irradiante, quanto de alguns avanços técnicos da radioterapia, que podem, por sua vez, beneficiar estes pacientes, oferecendo menor toxicidade e maior eficiência e rapidez, por exemplo.It is known that the aging of the world population during the twentieth century and the beginning of this new century is a first-order challenge for nations, especially in the socio-economic field. An important aspect of the aging of global population is that, for older age groups, the prevalence of degenerative diseases is also higher, including malignancies. On the other hand, among the population of patients with cancer, half of these patients will receive radiation therapy at some point in their illness and their individual characteristics can somehow influence the prognosis, the indication and daily doses of

  7. Indications for quality assurance in conformal radiotherapy in Italy; Indicazioni per l'Assicurazione di Qualita nella radioterapia ad intensita modulata

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    Banci Buonamici, F [Servizio Ospedaliero Dipartimentale Fisica Medica, Azienda Ospedaliera Careggi, Firenze (Italy); DE Angelis, C; Rosi, A; Tabocchini, M A [Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanita, Roma (Italy); Iotti, C [Radioterapia Oncologica, Arcispedale di Santa Maria Nuova, Reggio Emilia (Italy); Olmi, P [Dipartimento di Radioterapia, Istituto Nazionale per lo studio e la cura dei Tumori, Milano (Italy)

    2008-07-01

    Intensity-Modulated Radiation Therapy (IMRT) is an advanced and promising technique of external beam irradiation. IMRT is able to conform the dose distribution to the 3D tumour shape also for complex geometries, preserving surrounding normal tissues and reducing the probability of side effects. IMRT is a time consuming and complex technique and its use demands high level quality assurance. It is, therefore, very important to define conditions for its utilization. Professionals of Radiotherapy Centres, with experience in the IMRT use, have constituted a multidisciplinary working group with the aim of developing indications in this field. Purpose of the present document is to highlight relevant aspects of the technique, but also to underline the high complexity of the technique, whose implementation requires extreme attention of the staff of Radiotherapy Centres involved. [Italian] La Radioterapia ad Intensita Modulata (Intensity Modulated Radiation Therapy, IMRT) rappresenta una delle piu avanzate e promettenti tecniche di radioterapia oncologica. La possibilita di adattare la distribuzione della dose terapeutica alla geometria, anche molto complessa, di una massa tumorale consente di salvaguardare in modo ottimale i tessuti sani adiacenti riducendo quindi la probabilita di complicanze. L'IMRT e una tecnica di difficile esecuzione, dispendiosa per tempo impiegato e richiede particolare precisione. E quindi fondamentale cercare di definire in quali situazioni puo essere appropriato il suo impiego. Per questo si e costituito un gruppo di lavoro che ha visto coinvolti, con un approccio multidisciplinare, i Centri Italiani di Radioterapia con maggior esperienza nell'uso di questa tecnica. Questo documento si e posto come obiettivo quello di delineare le peculiarita della tecnica e di evidenziare come la sua elevata complessita esiga il massimo rigore nella sua implementazione.

  8. Efeito do tempo de espera para radioterapia na sobrevida geral em cinco anos de mulheres com câncer do colo do útero, 1995-2010

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    Maria Isabel do Nascimento

    2015-11-01

    Full Text Available Resumo A sobrevida geral em cinco anos e os fatores associados ao óbito foram avaliados em uma coorte de 342 mulheres com câncer do colo uterino indicadas para radioterapia na Baixada Fluminense, Rio de Janeiro, Brasil. A sobrevida geral foi de 25,3%, alcançando 60,8% para os casos até IIA. O ajustamento com uso do modelo de riscos proporcionais de Cox estendido mostrou risco de óbito aumentado para tumores IIB-IIIB (HR = 1,89; IC95%: 1,214; 2,957 e IVA-IVB (HR = 5,78; IC95%: 2,973; 11,265. A captação por citologia (HR = 0,58; IC95%: 0,362; 0,961 e o encaminhamento direto para o serviço de radioterapia na Baixada Fluminese (HR = 0,60; IC95%: 0,418; 0,875 foram os principais fatores protetores encontrados. O tempo de espera pela radioterapia (> 60 dias versus ≤ 60 dias foi não estatisticamente significativo, porém o retardo de quatro dias piorou os resultados (HR = 1,70; IC95%: 1,153; 2,513. O limite de 60 dias para iniciar a radioterapia deve ser respeitado com rigor, pois, a partir de 64 dias, o retardo mostrou associação significativa entre todos os pontos de corte de tempo de espera analisados e o risco de morte em cinco anos.

  9. Avaliação de métodos de cálculo de barreiras de protecão radiológica em instalações de radioterapia externa e braquiterapia

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    Rodrigues, Maria José Pereira

    2012-01-01

    Tese de mestrado integrado em Engenharia Biomédica e Biofísica (Radiações em Diagnóstico e Terapia), apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2012 O presente projeto visa a avaliação de métodos de cálculo de barreiras de proteção radiológica em instalações de radioterapia, onde são utilizadas técnicas como a radioterapia conformacional a três-dimensões (3D-CRT), a radioterapia de intensidade modulada (IMRT) e técnicas de braquiterapia de alta taxa de dose (HD...

  10. Evaluation of salivary flow in patients during head and neck radiotherapy Análise do fluxo salivar em pacientes durante a radioterapia em cabeça e pescoço

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    Paulo Rogério Ferreti Bonan

    2003-06-01

    Full Text Available Radiotherapy is frequently employed for the treatment of head and neck squamous cell carcinoma. Among the side effects, xerostomia is one of the most important. With the objective of evaluating the role of radiotherapy in salivary flow, we performed three salivary sample collections: at the beginning of, during, and immediately after radiotherapy. The results showed that the salivary flow values of the first collection were very similar to those of the control group. However, during treatment, there was a significant decrease of the salivary flow (p = 0.0008, which continued low immediately after radiotherapy (p = 0.0009. Our study showed that radiotherapy leads to an important reduction of salivary flow during and after radiotherapy.A radioterapia é um tratamento comumente empregado em pacientes portadores de carcinomas espinocelulares em cabeça e pescoço. Entre os efeitos colaterais locais, a xerostomia é um dos mais importantes. Com o objetivo de avaliar o efeito da radioterapia sobre o fluxo salivar, foram feitas 3 coletas salivares: no início, em um período intermediário e posteriormente ao tratamento radioterápico. Os resultados obtidos demonstraram médias de fluxo salivar semelhantes entre a coleta inicial e o grupo controle. Com o decorrer da radioterapia, houve diminuição significativa do fluxo salivar na coleta intermediária (p = 0,0008, que se manteve após o término da radioterapia (p = 0,0009. Nosso estudo enfatiza que há redução significativa do fluxo salivar durante e após a radioterapia.

  11. Anestesia ambulatorial para radioterapia em paciente portador de miastenia gravis: relato de caso Anestesia ambulatorial para radioterapia en paciente portador de miastenia gravis: relato de caso Outpatient anesthesia for radiotherapy in a patient with myasthenia gravis: case report

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    Raquel Marcondes Bussolotti

    2006-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A miastenia gravis (MG é doença auto-imune rara, caracterizada pela redução de receptores nicotínicos na junção neuromuscular, com incidência de 14/100.000. O objetivo deste relato foi descrever o caso de paciente portador de miastenia gravis submetido à anestesia geral balanceada, para tratamento radioterápico de carcinoma espinocelular de parótida, em regime ambulatorial. RELATO DO CASO: Paciente do sexo masculino, 87 anos, 87 kg, estado físico ASA III, com história de miastenia gravis; acidente vascular encefálico prévio (AVE; marca-passo por bloqueio atrioventricular total; hipertensão arterial sistêmica (HAS. Foram programadas sete sessões de radioterapia de 20 minutos para tratamento de tumor de parótida, sob anestesia geral. Na sala de radioterapia foi monitorizado com cardioscópio, monitor de pressão arterial não-invasiva, oxímetro de pulso, e submetido à anestesia geral com propofol e sevoflurano. Após a indução, foi mantido em ventilação espontânea com cânula de Guedel e cateter nasofaríngeo com O2 /sevoflurano, para acomodação da máscara imobilizadora. Na sala de recuperação pós-anestésica, não apresentou complicações. CONCLUSÕES: A escolha dos anestésicos e o acompanhamento clínico criterioso permitiram a boa evolução do paciente, com AVE prévio, cardiopata e idoso, submetido à anestesia geral balanceada para procedimento de aplicação de radioterapia, em regime ambulatorial.JUSTIFICATIVA Y OBJETIVOS: La Miastenia Gravis (MG es una enfermedad auto inmune rara, caracterizada por la reducción de receptores nicotínicos en la junción neuromuscular, con incidencia de 14/100.000. El objetivo de este relato fue el de describir el caso del paciente portador de miastenia gravis sometido a la anestesia general balanceada, para tratamiento radioterápico de carcinoma espinocelular de parótida en régimen ambulatorial. RELATO DEL CASO: Paciente del sexo masculino

  12. Radioterapia de intensidade modulada (IMRT para pacientes do SUS: análise de 508 tratamentos em dois anos de instalação da técnica

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    Harley Francisco de Oliveira

    2014-12-01

    Full Text Available Objetivo: A oferta de radioterapia de alta tecnologia para população atendida pelo Sistema Único de Saúde (SUS é limitada, por não pertencer ao rol de procedimentos e, muitas vezes, pela capacidade instalada frente à demanda e dificuldade de retenção de recursos humanos especializados. Dessa forma, o acesso à radioterapia de intensidade modulada (IMRT é restrito a poucos serviços no Brasil. Pretendemos apresentar as características dos primeiros 508 tratamentos de IMRT durante os primeiros anos de instalação da técnica em um hospital universitário. Materiais e Métodos: Foram analisados 508 tratamentos de IMRT, de maio de 2011 a setembro de 2013, que completaram a radioterapia. A técnica empregada foi multilâminas estático. Resultados: De um total de 4.233 pacientes tratados no período, 12,5% realizaram IMRT. As principais indicações foram para crânio, cabeça e pescoço, e próstata. Aproximadamente 30% das radioterapias de crânio e 50% das de próstata foram por IMRT. A toxicidade total foi 4%. Conclusão: Em razão das restrições de acesso à radioterapia e da não cobertura deste procedimento, as indicações de IMRT para pacientes do SUS devem ser apoiadas nos protocolos clínicos das instituições em acordo com sua realidade, com especial atenção à redução da toxicidade.

  13. Complicações bucais da radioterapia em cabeça e pescoço Oral complications of radiotherapy in the head and neck

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    Bruno Correia Jham

    2006-10-01

    Full Text Available A radioterapia é uma forma terapêutica amplamente utilizada para o tratamento das neoplasias malignas da cabeça e pescoço. Porém, altas doses de radiação em extensos campos que irão incluir a cavidade bucal, maxila, mandíbula e glândulas salivares freqüentemente resultam em diversas reações indesejadas. Dentre as complicações da radioterapia estão a mucosite, candidose, disgeusia, cárie por radiação, osteorradionecrose, necrose do tecido mole e xerostomia. OBJETIVO: O objetivo deste artigo é fazer uma breve revisão das reações adversas que podem ser detectadas durante o tratamento radioterápico em região de cabeça e pescoço. MÉTODO: A literatura pertinente que trata do assunto foi revisada. FORMA DE ESTUDO: Revisão de literatura. RESULTADOS: A radioterapia ainda está associada a diversas reações adversas, que afetam de forma significativa a qualidade de vida dos pacientes. CONCLUSÕES: O tratamento multidisciplinar, incluindo a equipe médica, o cirurgião-dentista, o fonoaudiólogo, o nutricionista e o psicólogo é a melhor alternativa para minimizar ou mesmo prevenir tais complicações.Radiotherapy is a treatment modality largely used for head and neck malignancies. However, high doses of radiation in large areas, including the oral cavity, maxilla, mandible and salivary glands may result in several undesired reactions. Mucositis, candidosis, disgeusia, radiation caries, osteoradionecrosis, soft tissue necrosis and xerostomia are some of radiotherapy’s complications. AIM: The aim of this study is to briefly review the side effects that may be seen in the oral cavity during or after radiotherapy treatment in the head and neck region. BASIC METHOD USED: Review of relevant literature. STUDY DESING: Literature review. RESULTS: Radiotherapy is still associated with several side effects, significantly affecting patients’ quality of life. CONCLUSIONS: A multidisciplinary treatment, including physicians, dentists

  14. Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors Avaliação de algumas seqüelas bucais pós-radioterapia em pacientes tratados de neoplasias de cabeça e pescoço

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    Cássia Maria Fischer Rubira

    2007-09-01

    Full Text Available The aim of this study was to evaluate the oral sequelae of radiotherapy in patients treated between 1999 and 2003 for head and neck tumors. One-hundred patients (24 women, 76 men ranging in age from 30 to 83 years (mean 59.2 years were examined. Time since radiotherapy ranged from 1 to 72 months (mean 28 months. The total mean radiation dose received by the patients was 5,955 cGy. The evaluation protocol included anamnesis, intraoral and extraoral examination, measurement of stimulated salivary flow and salivary pH. Symptoms reported by the patients included dry mouth (68%, dysphagia (38%, and dysgeusia (30%. In 64% of the patients, the mean stimulated salivary flow rate was less than 0.7 ml/min. The mean salivary pH was 6.97 (± 0.714. Stimulated salivary flow increased with increasing postradiotherapy time (p O objetivo deste estudo foi avaliar as seqüelas bucais provocadas pela radioterapia em pacientes com neoplasias de cabeça e pescoço, tratados entre 1999 e 2003. Foram examinados 100 pacientes (24 mulheres e 76 homens, com idades entre 30 e 83 anos (média de 59,2 anos. O tempo desde a radioterapia variou de 1 a 72 meses (média de 28 meses. A média da dose total de radiação recebida pelos pacientes foi de 5.955 cGy. O protocolo de avaliação consistiu de anamnese, exame físico, aferição do fluxo salivar estimulado e pHmetria da saliva. Os sintomas referidos foram boca seca (68%, disfagia (38% e disgeusia (30%. Em 64% dos indivíduos o valor médio do fluxo salivar estimulado esteve abaixo de 0.7 ml/min. O pH médio da amostra foi de 6.97 (± 0.714. O fluxo estimulado e a ocorrência de candidíase atrófica aumentaram conforme o aumento do tempo pós-radioterapia (p < 0.05. A ocorrência de mucosite esteve associada a maiores doses de radiação (p < 0.05. Dois casos de segundo tumor primário foram diagnosticados. O principal efeito da radioterapia na região de cabeça e pescoço foi a redução do fluxo salivar, apesar de

  15. Avaliação do efeito da laserterapia em baixa intensidade na reparação óssea após radioterapia externa – estudo experimental em ratos

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    Paixão, Darcy de Almeida

    2013-01-01

    Esse estudo teve como objetivo avaliar o efeito da Laserterapia em baixa intensidade na reparação de feridas cirúrgicas produzidas no tecido ósseo de ratos da raça Wistar. Para isso, foi artificialmente produzido um orifício no fêmur dos ratos e quatro dias após, os ratos foram submetidos a radioterapia externa com fonte de cobalto radioativo na dosagem de 3000 cGys. O grupo experimental recebeu adicionalmente sete sessões de Laserterapia de 780 hm, 40 nW, 100 J/cm2, por 100 seg. (qu...

  16. Comparação entre os volumes pulmonares irradiados com técnica bidimensional e tridimensional conformada na radioterapia de pacientes com tumores de pulmão localmente avançados Comparison between irradiated lung volumes with two-dimensional and three-dimensional conformal radiotherapy techniques for locally advanced lung cancer

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    Heloisa de Andrade Carvalho

    2009-10-01

    Full Text Available OBJETIVO: Comparar e quantificar os volumes pulmonares irradiados utilizando planejamentos bidimensional (2D e tridimensional (3D conformado na radioterapia de tumores de pulmão. MATERIAIS E MÉTODOS: Em 27 pacientes portadores de câncer de pulmão foi feito planejamento 3D e outro correspondente em 2D. As doses prescritas variaram de 45 a 66 Gy. Foram avaliadas as doses no volume alvo planejado (PTV, volume tumoral macroscópico (GTV e pulmões (volume de pulmão que recebe 20 Gy ou 30 Gy - V20 e V30, respectivamente, e dose média. Os órgãos de risco adjacentes (medula espinhal, esôfago e coração receberam doses abaixo dos limites de tolerância. RESULTADOS: O GTV variou de 10,5 a 1.290,0 cm³ (média de 189,65 cm³. Nos planejamentos 2D foi utilizado, em média, um total de 59,33 campos, e nos planejamentos 3D, 75,65 campos. Em todas as situações analisadas houve significante (p OBJECTIVE: To compare and quantify irradiated lung volumes using two-dimensional (2D and three-dimensional (3D conformal planning for radiotherapy in the treatment of lung cancer. MATERIALS AND METHODS: 2D and 3D conformal radiotherapy plannings were performed for 27 patients with lung cancer. Prescribed doses ranged from 45 to 66 Gy. The analysis covered the doses to planning target volume (PTV, gross tumor volume (GTV and lungs (lung volume receiving 20 Gy or 30 Gy - V20 and V30, respectively, and mean dose. The doses to adjacent organs at risk (spinal cord, esophagus and heart were maintained below the tolerance limits. RESULTS: GTV ranged from 10.5 to 1,290.0 cm³ (mean, 189.65 cm³. On average, a total of 59.33 fields were utilized in the 2D planning and 75.65 fields in the 3D planning. Lung volumes were significantly preserved (P < 0.05 with the 3D conformal planning in all the evaluated cases, with about 15% decrease in the irradiated lung volumes. Lungs without tumor were most benefited from this technique. CONCLUSION: 3D radiotherapy allowed a better

  17. Avaliação do pH salivar em pacientes submetidos a radioterapia à região de cabeça e pescoço

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    Gonçalves, Liliana Maria do Vale Costa

    2015-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária A disfunção das glândulas salivares, como sequela da Radioterapia (RT) traduz-se geralmente em hipofunção salivar e consequente diminuição do pH. Este estudo avaliou o comportamento do pH salivar num grupo de 35 indivíduos submetidos a RT com fracionamento convencional, por tumores malignos da região de cabeça e pescoço. O acompanham...

  18. Manejo da osteorradionecrose em pacientes submetidos à radioterapia de cabeça e pescoço = Osteoradionecrosis management in patients underwent head and neck radiotherapy

    Directory of Open Access Journals (Sweden)

    Vier, Fabiana Vieira

    2005-01-01

    Full Text Available Os efeitos colaterais da radioterapia instituída para tratamento de pacientes com câncer da região de cabeça e pescoço interferem significativamente na qualidade de vida desses indivíduos. Entre esses efeitos, podem-se citar mucosite, hipossialia, ageusia, cáries por radiação, trismo e osteorradionecrose (ORN. Esta última constitui uma complicação grave e de difícil tratamento. A presente revisão da literatura objetiva enfatizar aspectos da osteorradionecrose, abordando fatores etiológicos, características clínicas e radiográficas, prevalência, tratamento e prognóstico da enfermidade. O cumprimento de medidas protocolares antes, durante e após a radioterapia de cabeça e pescoço previne e minimiza a ocorrência de complicações como a ORN. As consultas de controle após o término da radioterapia são imprescindíveis e devem ser garantidas pela conscientização do paciente sobre a importância das mediadas preventivas

  19. Disfunção sexual em pacientes com câncer do colo uterino avançado submetidas à radioterapia exclusiva Sexual dysfunction in patients with advanced cervical cancer submitted to exclusive radiotherapy

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    Bebiana Calisto Bernardo

    2007-02-01

    Full Text Available OBJETIVO: identificar disfunções sexuais em pacientes com câncer de colo uterino submetidas à radioterapia exclusiva pela técnica de braquiterapia de alta taxa de dose. MÉTODOS: foi realizado um estudo descritivo do tipo corte transversal no período de janeiro a junho de 2004. O estudo envolveu 71 pacientes selecionadas de acordo o perfil estabelecido e que vinham sendo seguidas no ambulatório de pélvis do Hospital do Câncer de Pernambuco. Os dados foram coletados a partir de um questionário estruturado, complementado por um exame ginecológico visando investigar queixas de disfunção sexual após a radioterapia. Foi utilizado o programa estatístico Epi-Info 6.04 para processamento e análise dos dados. A análise descritiva foi feita pela média, mediana, valores máximo e mínimo. Para análise bivariada foram realizados os testes de homogeneidade marginal e McNemar, considerando um nível de significância de 5%. RESULTADOS: das complicações ginecológicas identificadas, destacam-se fibrose, estenose e atrofia vaginais (98,6, 76,1 e 71,8% dos casos, respectivamente. As disfunções sexuais identificadas foram: frigidez e falta de lubrificação, de excitação e de orgasmo, que ocorreram em 76,1% dos casos, falta de libido em 40,8% e vaginismo em 5,6% dos casos. CONCLUSÕES: as disfunções sexuais são freqüentes em pacientes com câncer do colo uterino avançado tratadas com radioterapia exclusiva utilizando o protocolo de braquiterapia de alta taxa de dose. Atenção específica deve ser dada à anamnese sexual e ao exame ginecológico durante o acompanhamento destas pacientes.PURPOSE: to identify sexual dysfunctions in patients with cancer of the uterine cervix submitted to exclusive radiotherapy, using the high dose rate (HDR brachytherapy technique. METHODS: a descriptive transversal study from January to June of 2004. The study involved 71 selected patients who had been followed in the pelvis outpatient clinic from the

  20. Independent dose calculation of the Tps Iplan in radiotherapy conformed with MLC; Calculo independiente de dosis del TPS Iplan en radioterapia conformada con MLC

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    Adrada, A.; Tello, Z.; Medina, L.; Garrigo, E.; Venencia, D., E-mail: jorge.alberto.adrada@gmail.com [Instituto Privado de Radioterapia, Obispo Oro 423, X5000BFI Cordoba (Argentina)

    2014-08-15

    The systems utilization of independent dose calculation in three dimensional-Conformal Radiation Therapy (3D-Crt) treatments allows a direct verification of the treatments times. The utilization of these systems allows diminishing the probability of errors occurrence generated by the treatment planning system (Tps), allowing a detailed analysis of the dose to delivering and review of the normalization point (Np) or prescription. The independent dose calculation is realized across the knowledge of dosimetric parameters of the treatment machine and particular characteristics of every individual field. The aim of this work is develops a calculation system of punctual doses for isocentric fields conformed with multi-leaf collimation systems (MLC), where the dose calculation is in conformity with the suggested ones by ICRU Report No. 42, 1987. Calculation software was realized in C ++ under a free platform of programming (Code::Blocks). The system uses files in format Rtp, exported from the Tps to systems of record and verification (Lantis). This file contains detailed information of the dose, Um, position of the MLC sheets and collimators for every field of treatment. The size of equivalent field is obtained from the positions of every sheet; the effective depth of calculation can be introduced from the dosimetric report of the Tps or automatically from the DFS of the field. The 3D coordinates of the isocenter and the Np for the treatment plan must be introduced manually. From this information the system looks the dosimetric parameters and calculates the Um. The calculations were realized in two accelerators a NOVALIS Tx (Varian) with 120 sheets of high definition (hd-MLC) and a PRIMUS Optifocus (Siemens) with 82 sheets. 705 patients were analyzed for a total of 1082, in plans made for both equipment s, the average uncertainty with regard to the calculation of the Tps is-0.43% ± 2.42% in a range between [-7.90 %, 7.50 %]. The major uncertainty was in Np near of the

  1. Deficiência progressiva dos hormônios adeno-hipofisários após radioterapia em adultos Progressive pituitary hormone deficiency following radiation therapy in adults

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    Rafaela A. Loureiro

    2004-10-01

    Full Text Available A radioterapia é um dos fatores desencadeantes do hipopituitarismo, mesmo quando não direcionada diretamente para o eixo hipotálamo-hipofisário, podendo resultar em redução de hormônios adeno-hipofisários, principalmente por lesão hipotalâmica. A perda da função da hipófise anterior é progressiva e geralmente na seguinte ordem: hormônio do crescimento, gonadotrofinas, adrenocorticotrofina e o hormônio estimulante da tireóide. Vários testes estão disponíveis para a confirmação das deficiências, sendo discutidos, neste artigo, os melhores testes para pacientes submetidos à irradiação. Enfatizamos que o desenvolvimento do hipopituitarismo após a radioterapia é dose e tempo dependente de irradiação, com algumas diferenças entre os eixos hipofisários. Portanto, a conscientização da necessidade de terapia em conjunto de endocrinologistas e oncologistas otimizará o tratamento e a qualidade de vida do paciente.Hypopituitarism can be caused by radiation therapy, even when it is not directly applied on the hypothalamic-pituitary axis, and can lead to anterior pituitary deficiency mainly due to hypothalamic damage. The progressive loss of the anterior pituitary hormones usually occurs in the following order: growth hormone, gonadotropin hormones, adrenocorticotropic hormone and thyroid-stimulating hormone. Although there are several different tests available to confirm anterior pituitary deficiency, this paper will focus on the gold standard tests for patients submitted to radiation therapy. We emphasize that the decline of anterior pituitary function is time- and dose-dependent with some variability among the different axes. Therefore, awareness of the need of a joint management by endocrinologists and oncologists is essential to improve treatment and quality of life of the patients.

  2. Implementação do processo de enfermagem em uma unidade de radioterapia: elaboração de instrumento para registro Implementación del proceso de enfermería en una unidad de radioterapia: elaboración de instrumento para el registro Implementation of nursing process in a radiotherapy unit: creation of a record card

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    Ana Francisca Vaz

    2002-06-01

    Full Text Available É meta de nosso serviço sistematizar a assistência de enfermagem a clientes portadoras de câncer genital e mamário, submetidas a tratamento ambulatorial em radioterapia, através do processo de enfermagem, utilizando-se, na fase diagnóstica, a taxionomia da North American Nursing Diagnosis Association (NANDA e os problemas colaborativos. Foram elaboradas fichas que permitissem o registro de forma sucinta e completa dos dados mais relevantes para a assistência de enfermagem, contendo: anamnese, orientações gerais a respeito do tratamento, principais diagnósticos de enfermagem e problemas colaborativos, intervenções, resultados esperados e evolução. Esses impressos foram testados no serviço e avaliados pela equipe que os desenvolveu quanto ao conteúdo e diagramação, até se obterem os modelos atuais que são apresentados neste artigo.Con el objetivo de sistematizar la asistencia de enfermería para las pacientes de cáncer genital y mamário, que hacen tratamiento en radioterapia, a través del proceso de enfermería, se hicieron fichas para el registro breve y completo de los datos más relevantes en relación con la atención de enfermería. En el proceso de enfermería fueron usados los diagnósticos de la taxonomía de la North American Nursing Diagnosis Association (NANDA y problemas colaborativos durante el periodo de investigación. Las fichas contienen: datos de anamnesis, orientaciones generales en relación con el tratamiento, principales problemas colaborativos, principales diagnósticos de enfermería, intervenciones, resultados esperados y evolución. Los instrumentos fueron probados en el servicio y evaluados por las personas que las hicieron en relación con su contenido y diagramación , hasta tener el formato actual que es el que se presenta en este artículo.The goal of our service is to systematize the nursing care provided to the clients with gynecological and mammary cancer who underwent radiation therapy

  3. Colonização e espécies de Candida em pacientes submetidos à radioterapia cervicofacial Candida colonization and species in patients submitted to head and neck radiotherapy

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    Paulo Rogério Ferreti Bonan

    2007-12-01

    Full Text Available Os objetivos deste estudo foram investigar a colonização por Candida associada à redução do fluxo salivar e identificar as espécies antes, durante e após a radioterapia em 20 pacientes portadores de carcinomas de células escamosas, comparando com dados obtidos em dois grupos-controle, um formado por 24 pacientes saudáveis e o outro, por nove pacientes submetidos à radioterapia por pelo menos um ano. A saliva total de todos os pacientes foi coletada pelo método não-estimulado. As unidades formadoras de colônia de Candida foram quantificadas e identificadas pelos testes bioquímicos, CHROMagar e Api 20 Aux. Os resultados evidenciaram, no grupo de estudo, redução progressiva do fluxo salivar entre a primeira e a terceira coleta (p = 0,001 e aumento da positividade de espécies, com predominância das espécies C. albicans e C. tropicalis, bem como de sua diversificação. Houve correlação significativa entre redução do fluxo salivar e colonização por Candida (p = 0,009. Após 12 meses, o fluxo salivar apresentavase baixo e houve maior incidência das espécies C. albicans e C. tropicalis. Em suma, os pacientes irradiados com doses tumoricidas em campos cervicofaciais apresentaram redução do fluxo salivar, aumento na colonização fúngica e diversificação das espécies durante e no final do tratamento.The aims of this study were to investigate Candida carriage associated with reduced salivary flow and to identify Candida species in 20 patients with squamous cell carcinoma before, during and after head and neck radiotherapy, comparing with 2 control groups, one compounded by 24 healthful patients and the other, by nine patients submitted to head and neck radiotherapy one year at least. Whole non stimulated saliva were collected from all patients. Candida unit form colonies were quantified and identified using biochemistry tests, CHROMagar and API 20 Aux. The results showed progressive reduction of salivary flow during

  4. Efeito da clorexidina na mucosite induzida por radioterapia em câncer de cabeça e pescoço Effects of chlorhexidine mouthwash on radiation induced mucosistis in head and neck cancer

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    Rogério Labbate

    2003-06-01

    Full Text Available A radioterapia em pacientes com neoplasias de Cabeça e Pescoço causa alterações na mucosa oral comprometendo a execução terapêutica e o resultado final. OBJETIVO: Avaliar o efeito protetor do gluconato de clorexidina, sobre a mucosa oral, durante o tratamento actínico fracionado e o seu reflexo na qualidade de vida referida pelos pacientes. FORMA DE ESTUDO: Clínico prospectivo. MATERIAL E MÉTODO: Foram selecionados 21 portadores de câncer de Cabeça e Pescoço alocados em dois grupos: grupo Placebo (n=11, 9H e 2M, idade média 58 anos água destilada - dois bochechos diários e grupo Medicação (n=10, 7H e 2M, idade média 52 anos gluconato de clorexidina a 0,12% - dois bochechos diários. Os pacientes foram avaliados semanalmente com exame local para detecção das alterações de mucosa (classificação de acordo com a WHO e Grupo de Terapia por Radiação em Oncologia - graus 0 a IV e preenchimento de questionário de qualidade de vida ressaltando os aspectos de dor, apetite, paladar e hábitos alimentares. A análise estatística realizada pelo teste exato de Fisher. RESULTADOS: A graduação da mucosite foi mais intensa no grupo Placebo em 6 das 10 semanas de avaliação. A freqüência e intensidade das dores foram piores no grupo Placebo na 4ª semana de radioterapia e a modificação de paladar foi mais intensa nos indivíduos que não usavam o medicamento apenas na 7ª semana. Não foram encontradas diferenças nos outros parâmetros de qualidade de vida. CONCLUSÃO: Podemos concluir que o gluconato de clorexidina não eliminou as lesões de mucosa mas diminuiu, significativamente, os seus efeitos deletérios e intensidade sem apresentar um reflexo persistente na qualidade de vida dos pacientes.The radiotherapy in patients with neoplasias of Head and Neck causes alterations in the oral mucous membrane interfering with the therapeutic execution and the final result. AIM: To evaluate the protective effect of the chlorhexidin

  5. Effects of preoperative pelvic irradiation on colonic anastomosis healing: an experimental study in rats Efeito da radioterapia pélvica pré-operatória na cicatrização de anastomoses colônicas: estudo experimental em ratos

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    Alexandre Franca

    2008-01-01

    Full Text Available PURPOSE: Colorectal anastomosis is a constant worry-issue among surgeons because of high rates of complications, specially the dehiscence. The preoperative irradiation on cancer surgeries might interfere in the healing process, leading to an unfavorable outcome. METHODS: In the present study, two groups of rats were irradiated previously to a colorectal anastomosis surgery, with intervals of 4 and 8 weeks between the procedures. Seven days after the surgery, healing process was evaluated for dehiscence presence and histologic inflammatory characteristics. Also, levels of hydroxyproline, metalloproteinases and vascular endothelial growth factor were measured. RESULTS: Our results showed a higher incidence of dehiscences on the animals submitted to irradiation, compared to controls, with a reduced inflammatory activity in the healing tissue. DISCUSSION: Comparing both irradiated groups, those irradiated 8 weeks before surgery showed higher levels of hydroxyproline and metalloproteinases, indicating higher efficiency of the healing process. In conclusion, preoperative irradiation interferes with intestinal anastomosis healing and a larger time interval between both procedures is safer in terms of the healing quality.INTRODUÇÃO: As anastomoses colorretais são motivos constante de preocupação por parte dos cirurgiões, em virtude do alto índice de complicações, principalmente as deiscências. O uso da radioterapia previamente à cirurgia, nos casos de doença neoplásica, pode interferir no processo cicatricial das anastomoses, e levar a uma evolução desfavorável. MÉTODOS: Os autores estudaram dois grupos de ratos, submetidos a radioterapia e à confecção de uma anastomose no cólon, com intervalo de 04 e de 08 semanas entre os dois procedimentos, comparando com um grupo controle. Após 07 dias da cirurgia, estudaram-se vários aspectos do processo cicatricial: presença de deiscência, características inflamatórias do tecido, dosagem

  6. Sistema computacional para dosimetria de nêutrons e fótons baseado em métodos estocásticos aplicado a radioterapia e radiologia

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    Bruno Machado Trindade

    2011-04-01

    Full Text Available OBJETIVO: Este artigo mostra um procedimento de conversão de imagens de tomografia computadorizada ou de ressonância magnética em modelo de voxels tridimensional para fim de dosimetria. Este modelo é uma representação personalizada do paciente que pode ser usado na simulação, via código MCNP (Monte Carlo N-Particle, de transporte de partículas nucleares, reproduzindo o processo estocástico de interação de partículas nucleares com os tecidos humanos. MATERIAIS E MÉTODOS: O sistema computacional desenvolvido, denominado SISCODES, é uma ferramenta para planejamento computacional tridimensional de tratamentos radioterápicos ou procedimentos radiológicos. Partindo de imagens tomográficas do paciente, o plano de tratamento é modelado e simulado. São então mostradas as doses absorvidas, por meio de curvas de isodoses superpostas ao modelo. O SISCODES acopla o modelo tridimensional ao código MCNP5, que simula o protocolo de exposição à radiação ionizante. RESULTADOS: O SISCODES vem sendo utilizado no grupo de pesquisa NRI/CNPq na criação de modelos de voxels antropomórficos e antropométricos que são acoplados ao código MCNP para modelar braquiterapias e teleterapias aplicadas a tumores em pulmões, pelve, coluna, cabeça, pescoço, e outros. Os módulos atualmente desenvolvidos no SISCODES são apresentados junto com casos exemplos de planejamento radioterápico. CONCLUSÃO: O SISCODES provê de maneira rápida a criação de modelos de voxels personalizados de qualquer paciente que podem ser usados em simulações por códigos estocásticos tipo MCNP. A combinação da simulação via MCNP com um modelo personalizado do paciente traz grandes melhorias na dosimetria de tratamentos radioterápicos.

  7. Commissioning of a linear accelerator to execute volumetric modulated arc therapy; Comissionamento de um acelerador linear para realizacao da radioterapia em arco modulada volumetricamente

    Energy Technology Data Exchange (ETDEWEB)

    Goncalves, Leandro R.; Santos, Gabriela R.; Menegussi, Gisela; Silva, Marco A.; Passaro, Anderson M.; Rodrigues, Laura N., E-mail: leandrorg11@hotmail.com [Instituto do Cancer do Estado de Sao Paulo (ICESP), Sao Paulo, SP (Brazil)

    2013-08-15

    Radiotherapy techniques like VMAT allow complex dose distributions modulating the beam intensity within the irradiation field from the handling of multi-blade collimators, variations in dose rate, different speeds of rotation of the gantry and collimator angle allowing greater conformation of the dose to the tumor volume and a lower dose to healthy tissues. To ensure proper dose delivery, the linear particle accelerator must be able to monitor and perform all the variation in these parameters simultaneously. In this work dosimetric tests obtained in the literature that aims to commission, implement and ensure the quality of VMAT treatments were performed performed in the Institute of Cancer of Sao Paulo State (ICESP). From the results obtained it was established a program of quality control for the linear accelerator studied. The linearity and stability response of ionization chamber monitoring, leafs accuracy positioning, flatness and symmetry of beam to VMAT irradiations were evaluated. The obtained results are in agreement with the literature. It can be concluded that the accelerator studied is able to satisfactorily control the variation of all necessary parameters to perform the VMAT treatments. (author)

  8. Dosimetric tests for treatment planning commissioning in 3DCRT; Testes dosimetricos para comissionamento de sistemas de planejamento em radioterapia 3DCRT

    Energy Technology Data Exchange (ETDEWEB)

    Goncalves, Leandro R.; Pieri, Karen; Silva, Marco A.; Santos, Gabriela R.; Sales, Camila P.; Rubo, Rodrigo A.; Nakandakari, Marcos V.N.; Cunha, Ana Paula V; Santos, Caroline Z.; Rodrigues, Laura N.; Furnari, Laura, E-mail: leandrorg11@hotmail.com [Universidade de Sao Paulo (USP), SP (Brazil). Hospital das Clinicas. Servico de Radioterapia

    2012-12-15

    The radiotherapy evolution from 2D treatments to 3D conformal treatments was possible after the advent the treatment planning systems commercially available and tridimensional images techniques like computed tomography. These systems have tools that allow delineate anatomical structures from tomographic images. Calculations dose tools allow the planner evaluate the dose received in the anatomical structures. When these systems are acquired or an upgrade is made many dosimetric and non-dosimetric tests need to be performed to know the system limitations and correct functioning and to verify the correct dosimetric data insertion. This study was based in International Atomic Energy Agency protocols, Task Groups documents from American Association of Physics in Medicine, and other papers. A dosimetric test set was done to commissioning the Eclipse 10.0.28 (Varian Medical Systems) treatments planning system This version has two photon calculation algorithm (Pencil Beam Convolution and Analytical Anisotropic Algorithm – AAA) and Gaussian Pencil Beam algorithm for electron beams. However, tests for AAA it was not performed. In this study was possible to conclude that the dosimetric data was correctly added in the treatment planning system. Some results allowed to understand the algorithm limitations to calculate dose distributions in specifics situations, that was not clinically relevant in our routine. (author)

  9. Non conformance in fittings for critical environmental conditions; Conexoes nao conformes para trabalho em meios criticos

    Energy Technology Data Exchange (ETDEWEB)

    Sgarbi, Mauricio [Promon Engenharia, Sao Paulo, SP (Brazil); Zeemann, Annelise [Tecmetal, Rio de Janeiro, RJ (Brazil)

    2012-07-01

    Carbon steel fittings ASTM A105 and ASTM A234 WPB are widely applied for refinery piping and equipment and the detection, by a construction company, of a fitting manufacturing non conformance (NC) showed to be an unexpected problem of enormous dimension, since part of the plant was in startup conditions, with the NC fittings already welded, hydrostatically tested, painted and, in several lines, already thermally insulated. The challenge of treating the NC in a quick way with 100% confidence was even more difficult due to the metallurgical nature of the problem, not in the expertise of a construction company, which analyzed and decided about changing or accepting about 11,251 fittings of small diameter. This decision could impact directly in the refinery schedule for urgently running the unity. This work shows how the NC was detected, the extension of the problem that required field chemistry and hardness analysis of 7.425 parts, the metallurgical nature of the NC and the adopted treatment, considering that this unity presents aggressive environments and critical conditions like H2S. After a complex metallurgical study it was possible to change only 30% of the NC fittings, although some additional heat treatments were required to assure favorable conditions for piping use. (author)

  10. RTOG criteria to evaluate acute skin reaction and its risk factors in patients with breast cancer submitted to radiotherapy Evaluación de las reacciones agudas de la piel y sus factores de riesgo en pacientes con cáncer de mama sometidos a radioterapia Avaliação das reações agudas da pele e seus fatores de risco em pacientes com câncer de mama submetidas à radioterapia

    Directory of Open Access Journals (Sweden)

    Ana Maria Teixeira Pires

    2008-10-01

    al enfermero planificar conductas más adecuadas e individualizadas para cada paciente y contribuir para optimizar el tratamiento.O objetivo deste estudo foi avaliar e classificar as reações de pele, segundo os critérios do Radiation Therapy Oncology Group (RTOG e caracterizar fatores que possam interferir nessas reações. A metodologia usada foi o estudo prospectivo, com 86 mulheres submetidas à radioterapia na mama, dose total de 5040cGy, com Acelerador Linear de 6 MeV. Coletou-se dados pessoais e foi medido o tamanho da mama (distância entre a separação dos campos e altura da mama. A avaliação da pele na área de tratamento foi realizada semanalmente. Concluiu-se que a altura da mama e a técnica de tratamento foram significantes na análise univariada, para incidência de reação de pele grau 3. Porém, apenas a altura da mama foi fator significante na análise multivariada para a gravidade da reação de pele. A chance de ocorrer reação grau 3 aumenta 2,61 vezes a cada aumento de 1 unidade de altura em cm. Esses achados permitem ao enfermeiro programar condutas mais adequadas e individualizadas a cada paciente e contribuir para a otimização do tratamento.

  11. Radiotherapy of intensity modulated VS conformational in the treatment of carcinoma of the prostate. A dosimetric comparison; Radioterapia de intensidad modulada VS conformacional en el tratamiento de carcinoma de prostata. Una camparacion dosimetrica

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez Martin, G.; Garcia Vicente, F.; Zapatero Laborda, A.; Bermudez Luna, R.; Roch Gonzalez, M.; Perez Gonzalez, L.; Torres Escobar, J. J.

    2013-07-01

    The intensity modulated (IMRT) radiation therapy is a technique of high conformation which, by its nature, has as one of its main directions prostate cancer radiotherapy treatment. The purpose of this work is presents results of the dosimetric indicators collected in our hospital a number of patients of carcinoma of the prostate with standard three-dimensional Conformal technique (3D-CRT) and IMRT. Aims to demonstrate and quantify with a statistical methodology that, establishing an adequate Protocol of IMRT, significant reductions in risk organ doses can be obtained by keeping the same prescription to the white volume. (Author)

  12. Estimate of the damage in organs induced by neutrons in three-dimensional conformal radiotherapy; Estimacion del dano en organos inducido por neutrones en radioterapia conformada en 3D

    Energy Technology Data Exchange (ETDEWEB)

    Benites R, J. L. [Centro Estatal de Cancerologia de Nayarit, Servicio de Seguridad Radiologica, Calzada de la Cruz 118 sur, 63000 Tepic, Nayarit (Mexico); Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico); Uribe, M. del R., E-mail: jlbenitesr@prodigy.net.mx [Instituto Tecnico Superior de Radiologia, Calle Leon No. 129, 63000 Tepic, Nayarit (Mexico)

    2014-08-15

    By means of Monte Carlo methods was considered the damage in the organs, induced by neutrons, of patients with cancer that receive treatment in modality of three-dimensional conformal radiotherapy (3D-CRT) with lineal accelerator Varian Ix. The objective of this work was to estimate the damage probability in radiotherapy patients, starting from the effective dose by neutrons in the organs and tissues out of the treatment region. For that a three-dimensional mannequin of equivalent tissue of 30 x 100 x 30 cm{sup 3} was modeled and spherical cells were distributed to estimate the Kerma in equivalent tissue and the absorbed dose by neutrons. With the absorbed dose the effective dose was calculated using the weighting factors for the organ type and radiation type. With the effective dose and the damage factors, considered in the ICRP 103, was considered the probability of damage induction in organs. (Author)

  13. Impacto da nutrição enteral na toxicidade aguda e na continuidade do tratamento dos pacientes com tumores de cabeça e pescoço submetidos a radioterapia com intensidade modulada

    Directory of Open Access Journals (Sweden)

    Liêvin Matos Rebouças

    2011-02-01

    Full Text Available OBJETIVO: Analisar o impacto da terapia nutricional enteral na manutenção do peso corpóreo e na necessidade de replanejamento e/ou interrupção da radioterapia em pacientes com câncer de cabeça e pescoço submetidos a radioterapia de intensidade modulada (IMRT. MATERIAIS E MÉTODOS: Foram analisados, retrospectivamente, os pacientes submetidos a IMRT entre janeiro de 2005 e outubro de 2008, com a inclusão de 83 casos. RESULTADOS: A idade mediana foi de 58,6 anos. Em apenas em cinco pacientes (6% houve interrupção do tratamento, que variou de 4 a 18 dias, e em 19 casos (23% houve necessidade de replanejamento. A terapia nutricional enteral foi instituída antes do início da radioterapia em 16 pacientes (19%. Perda de peso > 5% ocorreu em 58 casos (70%, sendo mais prevalente no grupo de pacientes em que a terapia nutricional enteral não foi instituída pré-radioterapia. Na comparação entre os grupos não houve diferença significativa na realização de replanejamento (25% versus 21%; p = 0,741 ou na ocorrência e duração da interrupção da radioterapia. CONCLUSÃO: A terapia nutricional enteral tem um claro ganho na manutenção do peso corporal, porém, não houve um benefício na realização da gastrostomia percutânea endoscópica ou da sonda nasoenteral em relação à interrupção e ao replanejamento da radioterapia.

  14. Comparación de costes de tres tratamientos del cáncer de próstata localizado en España: prostatectomía radical, braquiterapia prostática y radioterapia conformacional externa 3D Cost comparison of three treatments for localized prostate cancer in Spain: radical prostatectomy, prostate brachytherapy and external 3D conformal radiotherapy

    Directory of Open Access Journals (Sweden)

    Virginia Becerra Bachino

    2011-02-01

    Full Text Available Objetivo: Comparar los costes de los tratamientos más establecidos para el cáncer de próstata localizado según grupos de riesgo, edad y comorbilidad, desde la perspectiva del proveedor asistencial. Métodos: Comparación de costes en pacientes reclutados consecutivamente entre 2003 y 2005 en una unidad funcional de tratamiento del cáncer de próstata. La utilización de servicios hasta 6 meses después del inicio del tratamiento se obtuvo de las bases de datos hospitalarias, y los costes directos se estimaron mediante cálculo microcoste. La información sobre las características clínicas de los pacientes y los tratamientos recogió prospectivamente. Los costes se compararon mediante tests no paramétricos de comparación de medianas (Kruskall-Wallis y un modelo semilogarítmico de regresión múltiple. Resultados: La diferencia de costes fue estadísticamente significativa: medianas de 3229.10 €, 5369.00 € y 6265.60 € para los pacientes tratados con radioterapia conformacional externa 3D, braquiterapia, y prostatectomía radical retropública, respectivamente (pObjective: To compare the initial costs of the three most established treatments for clinically localized prostate cancer according to risk, age and comorbidity groups, from the healthcare provider's perspective. Methods: We carried out a cost comparison study in a sample of patients consecutively recruited between 2003 and 2005 from a functional unit for prostate cancer treatment in Catalonia (Spain. The use of services up to 6 months after the treatment start date was obtained from hospital databases and direct costs were estimated by micro-cost calculation. Information on the clinical characteristics of patients and treatments was collected prospectively. Costs were compared by using nonparametric tests comparing medians (Kruskall-Wallis and a semi-logarithmic multiple regression model. Results: Among the 398 patients included, the cost difference among treatments was

  15. Elaboração e implementação de um programa para verificação dos cálculos das unidades monitoras em radioterapia Development and implementation of a software for assessment of calculations in radiotherapy monitor units

    Directory of Open Access Journals (Sweden)

    Márcio Rogério Müller

    2005-12-01

    Full Text Available OBJETIVO: Desenvolvimento e implementação de um programa, fundamentado no algoritmo de cálculo manual, para verificação dos cálculos de unidades monitoras em radioterapia e estabelecimento de patamares de aceitação, como mecanismo de garantia da qualidade. MATERIAIS E MÉTODOS: Os dados apresentados foram obtidos a partir dos aceleradores lineares modelo Clinac 600C e 2100C, da Varian, e o sistema de planejamento de tratamento computadorizado utilizado foi o CadPlan™. RESULTADOS: Para os feixes de 6 MV os patamares de aceitação para desvios entre os cálculos de unidades monitoras, separados por região de tratamento, foram: mama (0,0% ± 1,7%, cabeça e pescoço (1,5% ± 0,5%, hipófise (-1,7% ± 0,5%, pelve (2,1% ± 2,1% e tórax (0,2% ± 1,3%. Para os feixes de 15 MV, o patamar sugerido para pelve em todas as técnicas de tratamento foi de (3,2% ± 1,3%. CONCLUSÃO: Os dados são suficientes para justificar seu uso na prática clínica como ferramenta no programa de garantia da qualidade.OBJECTIVE: To develop and implement a software based on the manual calculation algorithm for verification of the calculations in radiotherapy monitor units and to establish acceptance levels as a mechanism of quality assurance. MATERIALS AND METHODS: Data were obtained from Clinac 600C and 2100C Varian linear accelerators and the computerized treatment planning system used was CadPlan™. RESULTS: For the 6 MV beams the acceptance levels for deviations among the calculations of monitor units, divided by treatment area, were the following: breast (0.0% ± 1.7%, head and neck (1.5% ± 0.5%, hypophysis (-1.7% ± 0.5%, pelvis (2.1% ± 2.1% and thorax (0.2% ± 1.3%. For the 15 MV beams the suggested level for pelvis in all the treatment techniques was (3.2% ± 1.3%. CONCLUSION: The present data are sufficient to justify the use of the software in the clinical practice as a tool for the quality assurance program.

  16. Complicaciones tardías de la radioterapia ocular

    OpenAIRE

    González García, Julio Lázaro; Santos Silva, Dania; Abreu Perdomo, Franklyn Alain; Melgares Ramos, María de los Ángeles; Valdivia Bregado, Yamelyn Tania

    2016-01-01

    La radioterapia es uno de los pilares terapéuticos utilizados en la oncología, no exenta de producir daño ocular, lo que constituye un fenómeno bien establecido. La aparición de complicaciones continúa siendo la principal preocupación de la aplicación de la radioterapia, a pesar del empleo de nuevas estrategias que buscan reducir las complicaciones y mejorar el índice terapéutico. Se presenta una paciente femenina de 63 años con diagnóstico de carcinoma epidermoide de la conjuntiva, moderadam...

  17. Efeito da radioterapia na função pulmonar e na fadiga de mulheres em tratamento para o câncer de mama Efecto de la radioterapia en la función pulmonar y en la fatiga de mujeres en tratamiento para el cáncer de mama Effect of radiotherapy on pulmonary function and fatigue of women undergoing treatment for breast cancer

    Directory of Open Access Journals (Sweden)

    Dayane Evellyn dos Santos

    2013-03-01

    Full Text Available O presente estudo comparou a função pulmonar e a fadiga de mulheres antes e após a radioterapia (RT adjuvante para tratamento do câncer de mama, e correlacionou a função pulmonar com a dose de radiação e fadiga. Foi conduzido um estudo observacional longitudinal envolvendo 20 mulheres. A função pulmonar foi avaliada pela espirometria (ClementClarke® e manovacuometria (GlobalMed®, modelo MVD 300, e a fadiga pelo Functional Assessment of Cancer Therapy Fatigue (FACT-F. Todas as avaliações foram realizadas antes da primeira sessão e uma semana após o término da RT adjuvante. Para a análise estatística foram utilizados os testes Wilcoxon Signed Rank Test e correlação de Spearman, adotando-se nível de significância pEl presente estudio comparó la función pulmonar y la fatiga de mujeres antes y después de la radioterapia (RT como ayudante para el tratamiento del cáncer de mama, y se correlacionó la función pulmonar con la dosis de radiación y fatiga. Fue realizado un estudio observacional longitudinal involucrando 20 mujeres. La función pulmonar fue evaluada por espirometría (ClementClarke® y manovacuometría (GlobalMed®, modelo MVD 300 y, la fatiga fue evaluada por la Functional Assessment of Cancer Therapy Fatigue (FACT-F. Todas las evaluaciones fueron realizadas antes de la primera sesión y una semana después del término de la RT. Para el análisis estadístico fueron utilizados los tests Wilcoxon Signed Rank Test y correlación de Spearman, adoptando un nivel de significancia pThis study compared the pulmonary function and fatigue in patients before and after adjuvant radiotherapy (RT and correlated the pulmonary function with the radiotherapy dose and fatigue. A longitudinal and observational study was conducted involving 20 women. Pulmonary function was evaluated by digital lung spirometry (ClementClarke® and manometry (GlobalMed®, model MVD 300 and fatigue was analyses by the Functional Assessment of

  18. Complicaciones tardías de la radioterapia ocular

    Directory of Open Access Journals (Sweden)

    Julio Lázaro González García

    Full Text Available La radioterapia es uno de los pilares terapéuticos utilizados en la oncología, no exenta de producir daño ocular, lo que constituye un fenómeno bien establecido. La aparición de complicaciones continúa siendo la principal preocupación de la aplicación de la radioterapia, a pesar del empleo de nuevas estrategias que buscan reducir las complicaciones y mejorar el índice terapéutico. Se presenta una paciente femenina de 63 años con diagnóstico de carcinoma epidermoide de la conjuntiva, moderadamente diferenciado G-II, invasor (T3N0M0 en ojo izquierdo, que llevó tratamiento quirúrgico y radioterapia superficial complementaria. Como complicación tardía, la paciente presentó catarata radiógena, que recibió tratamiento quirúrgico, además de aneurismas conjuntivales en el área tratada.

  19. A profissão de advogado conforme apresentada em jornais paraibanos

    Directory of Open Access Journals (Sweden)

    Sandra Souza da Silva

    2014-12-01

    Full Text Available A pesquisa teve o objetivo de identificar a imagem da profissão de advogado disseminada por um jornal da Paraíba. Seus fundamentos focalizam os conceitos de grupo funcional e identidade coletiva. Desenvolvemos pesquisa documental com análise de conteúdo categórica para tratar o material selecionado: 382 reportagens dos anos de 2001 e 2003. Identificamos duas amplas categorias: (a ações político-associativas e (b exercício profissional. Os resultados empíricos nos permitiram identificar aspectos centrais na construção da identidade profissional, como: a influência do exercício profissional e do órgão de representação na sociedade; a atribuição de importância ao poder; e a capacitação entre as preocupações dos profissionais. Em síntese, encontramos uma identidade coletiva refletindo as tradições históricas no país.

  20. The oncologic radiotherapy experience for patients: a poison-drug La experiencia de los pacientes sometidos a radioterapia oncológica: una medicina-veneno A experiência da radioterapia oncológica para os pacientes: um remédio-veneno

    Directory of Open Access Journals (Sweden)

    Rosani Manfrin Muniz

    2008-12-01

    áncer.O estudo objetivou compreender a experiência da radioterapia oncológica para os pacientes. A abordagem da antropologia interpretativa e o método etnográfico nortearam a investigação. Foram informantes dez pacientes de ambos os sexos, na faixa etária de 34 a 80 anos, acompanhados durante o tratamento radioterápico. Os dados foram coletados por entrevistas semi-estruturadas, observação participante e levantamento em prontuários. A análise dos discursos dos informantes possibilitou a identificação das unidades de significado: o encontro com a radioterapia, o corpo como veículo de ação da radioterapia e as práticas alternativas de cuidado aliviando os efeitos do tratamento. Compreende-se, aqui, que a experiência da radioterapia oncológica significou para esses pacientes a necessidade de se submeterem a uma terapêutica com característica de remédio-veneno, que causa temor, mas que era necessária se a meta fosse a cura ou mesmo a sobrevivência ao câncer.

  1. 3D conformal external beam radiation therapy for prostate carcinoma: an experiment of Instituto do Radium de Campinas with 285 patients; Radioterapia externa conformada 3D para o carcinoma de prostata: experiencia do Instituto do Radium de Campinas com 285 pacientes

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Ricardo Akiyoshi [Hospital de Caridade Dr. Astrogildo de Azevedo, Santa Maria, RS (Brazil); Monti, Carlos Roberto; Trevisan, Felipe Amstalden [Instituto do Radium de Campinas (IRC), Campinas, SP (Brazil); Jacinto, Alexandre Arthur [Fundacao Pio XII, Barretos, SP (Brazil). Hospital de Cancer de Barretos

    2009-03-15

    Objective: To report the outcomes of 3D conformal radiation therapy for prostate cancer in a single institution. Materials and methods: From July 1997 to January 2002, 285 consecutive patients with prostate cancer were submitted to 3D conformal radiation therapy receiving a median dose of 7920 cGy to the prostate, and were retrospectively evaluated. The patients distribution according to the level of risk was the following: low risk - 95 (33.7%); intermediate risk - 66 (23.4%); high risk -121 (42.9%) patients. Results: Median follow-up of 53.6 months (3.6.95.3 months) demonstrated 85.1% actuarial five-year overall survival, 97.0% specific cause survival, 94.2% five-year distant metastasis-free survival, and 75.8% five-year biochemical recurrence-free survival. Rates of five-year actuarial survival free from late rectal and urinary toxicity were 96.4% and 91.1% respectively. Pre-3D conformal radiation therapy transurethral resection of the prostate and doses > 70 Gy in 30% of the bladder volume implied a higher grade 2-3 late urinary toxicity in five years (p = 0.0002 and p = 0.0264, respectively). Conclusion: The first experiment with 3D conformal radiation therapy reported in Brazil allowed high radiation doses with acceptable levels of urinary and rectal toxicity. Pre-3D conformal radiation therapy transurethral resection of prostate may determine a higher risk for post-irradiation grade 2-3 late urinary toxicity. At the tomography planning, the reduction of the radiation dose to . 70 Gy in 30% of the bladder volume may reduce the risk for late urinary complications. (author)

  2. Seguridad del paciente en Radioterapia Intraoperatoria: Impacto de los elementos controlados por el Radiofisico

    Science.gov (United States)

    Tarjuelo, Juan Lopez

    Introduccion: En la administracion de la radioterapia intervienen profesionales y equipos de tratamiento, por lo que existe el riesgo de error y se precisa que dicho equipamiento funcione conforme a lo esperado. A los radiofisicos les corresponde participar en las actividades de garantia o aseguramiento de la calidad, incluyendo el control de calidad de los equipos, y en la evaluacion de los riesgos asociados. La radioterapia intraoperatoria (RIO) es una tecnica radioterapica de intensificacion de dosis, altamente selectiva, dirigida a volumenes anatomicos restringidos durante el tratamiento quirurgico oncologico, basada en la administracion de una dosis absorbida alta por medio de un haz de electrones tras el examen visual directo del lecho tumoral. Como incorporar los ultimos avances en el refuerzo de la seguridad en radioterapia es una tarea ambiciosa y compleja, resulta mas concreta y de inmediata aplicacion su introduccion en la RIO. El objetivo es analizar los elementos que reducen los riesgos y aumentan la seguridad en la RIO y su dosimetria, y valorar la funcion del radiofisico en esta labor. Material y metodos: Se emplearon el planificador Radiance de GMV y el acelerador lineal de los tratamientos de RIO Elekta Precise, controlado con el verificador diario de haces Daily QA Check 1090 y medido con las camaras de ionizacion PPC 40, FC65-G y FC65-P de PTW-Freiburg, a su vez verificadas con fuentes radiactivas adecuadas de estroncio-90 modelos CDP y CDC de IBA Dosimetry. Se realizo un analisis de modos de fallo y efectos (failure mode and effect analysis, FMEA) con el fin de identificar los elementos que forman la RIO y aplicar las herramientas necesarias para la minimizacion de los riesgos y la mejora de la seguridad en la tecnica. Se estudiaron las verificaciones diarias de dicho acelerador Precise con el control estadistico de procesos (statistical process control, SPC) y se simularon intervenciones para devolverlo al estado llamado en control. El SPC

  3. A utilização da radioterapia no tratamento do carcinoma de células escamosas cutâneo felino avançado

    Directory of Open Access Journals (Sweden)

    S.C.S. Cunha

    2014-02-01

    Full Text Available Avaliou-se a eficácia da radioterapia no tratamento de felinos portadores de carcinoma de células escamosas cutâneo avançado. Um protocolo de fracionamento padrão de radioterapia foi aplicado em seis gatos portadores de uma ou mais lesões cutâneas de carcinoma de células escamosas, em um total de sete lesões neoplásicas, confirmadas por meio de análise histológica. Uma lesão foi classificada como T2 e seis como T4, segundo o sistema de estadiamento da Organização Mundial de Saúde para tumores epidermais de felinos. Os animais foram submetidos a doze frações radioterápicas de 4 Gy, realizadas três vezes por semana, utilizando-se um equipamento de ortovoltagem. Utilizaram-se energia de 120 Kv, 15mA e filtro 2mm de alumínio, o cone usado foi de 6x8cm, e a distância foco-pele foi de 30cm. As lesões foram acompanhadas durante todo o tratamento radioterápico e 30 e 60 dias após o seu término. Neste estudo, 87% das lesões resultaram em remissão completa, e 13%, em remissão parcial. Os efeitos colaterais do tratamento radioterápico, de acordo com a tabela de critérios de toxicidade aguda da Veterinary Radiation Therapy Oncology Group, foram leves e reversíveis em todos os casos, e incluíram eritema cutâneo, epilação e rinite. Considerou-se a radioterapia segura para felinos com carcinoma de células escamosas cutâneo, levando a efeitos colaterais leves, e pode representar uma boa opção terapêutica.

  4. Study of the conformal symmetry breaking in field theories in gravitational background using path integrals; Estudo da quebra de simetria conforme em teorias de campo em fundo gravitacional com uso de integrais de caminho

    Energy Technology Data Exchange (ETDEWEB)

    Souza Alves, Marcelo de

    1990-03-01

    Some general aspects on field theories in curved space-time and a introduction to conformal symmetry are presented.The behavior of the physical systems under Weyl transformations is discussed. The quantization of such systems are performed through the functional integration method. The regularization in curved space-time is also discussed. An application of this analysis in String theories is made. 42 refs.

  5. Cardiovascular effects of radiation therapy; Efectos cardiovasculares de la radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez, Jose A.G.; Leiva, Gustavo [Hospital Britanico, Buenos Aires (Argentina).Servicio de Cardiologia; Schwartz, Laura; D' Angiola, Marisa [Hospital de Ninos ' Dr. Ricardo Gutierrez' , Buenos Aires (Argentina)

    2001-03-15

    Therapeutic mediastinal irradiation can induce heart disease with variable degree of cardiac engagement. Heart disease manifestations depend on the grade of involvement of the different cardiac structures. During the first two years following irradiation, pericarditis with or without pericardial effusion is the most common manifestation of toxicity related to radiation therapy. Later on, after a latency period of five to ten years, a constrictive pericarditis may develop. Other type of late cardiac toxicities due to irradiation are restrictive cardiomyopathy, multiple valvular disease, coronary artery disease and different atrioventricular conduction disturbances. The therapeutic approach to this kind of heart disease has to be focused on its progressive course and in the possibility of a global involvement of all the cardiac structures. Pericardiectomy is strongly recommended for recurrent pericardial effusion with cardiac tamponade. Cardiac surgery for myocardial revascularization or valvular disease can be performed with variable results; the presence of myocardial fibrosis can significantly affect perioperative management and long-term results. Cardiac transplantation is a promissory option for those patients with end-stage cardiac failure. Immunosuppressive regimens are not associated with recurrence of malignancy. (author) [Spanish] La radioterapia aplicada sobre el mediastino puede afectar las diferentes estructuras cardiacas. De la magnitud de ese compromiso dependera la aparicion de diversas manifestaciones clinicas. La pericarditis, con derrame o sin el, es lo mas habitual en los dos primeros anios; algunas evolucionan hacia la cronicidad para desarrollar, cinco a diez anios mas tarde, una pericarditis constrictiva. Otras manifestaciones tardias inducidas por la radioterapia pueden ser miocardiopatia restrictiva por fibrosis intersticial, disfunciones valvulares multiples, enfermedad obstructiva coronaria y trastornos en el sistema de conduccion

  6. Las diferentes modalidades de la radioterapia: externa, braquiterapia e intraoperatoria. Indicaciones

    Directory of Open Access Journals (Sweden)

    Manuel Algara López

    Full Text Available Conclusiones: Se puede afirmar que la radioterapia contribuye a aumentar la supervivencia de las pacientes con cáncer de mama; las mejoras tecnológicas experimentadas en los últimos años han contribuido de forma importante a disminuir la toxicidad; estas mejoras permiten concentrar la radioterapia en menos sesiones, incluso en una única de forma intraoperatoria en un grupo muy seleccionado de pacientes; y que debemos seguir investigado para conocer en que pacientes podemos disminuir nuestros tratamientos, especialmente a nivel ganglionar.

  7. Condição periodontal de indivíduos submetidos à radioterapia associada ou não à quimioterapia das vias aerodigestivas superiores: um estudo prospectivo

    OpenAIRE

    Audrey Cristina Bueno

    2009-01-01

    Estudos que investigam a progressão da doença periodontal em pacientes submetidos à radioterapia, como parte do tratamento de tumores malignos das vias aerodigestivas superiores (principalmente nos tumores de boca), mostram aumento da perda de inserção periodontal, que pode ser explicada por uma associação de fatores como ação direta da radiação sobre os tecidos, acúmulo de biofilme bacteriano e por alteração da resposta imunológica do hospedeiro. Entretanto estes estudos são poucos e com tam...

  8. Cryo-EM of the pathogenic VCP variant R155P reveals long-range conformational changes in the D2 ATPase ring.

    Science.gov (United States)

    Mountassif, Driss; Fabre, Lucien; Zaid, Younes; Halawani, Dalia; Rouiller, Isabelle

    2015-12-25

    Single amino acid mutations in valosin containing protein (VCP/p97), a highly conserved member of the ATPases associated with diverse cellular activities (AAA) family of ATPases has been linked to a severe degenerative disease affecting brain, muscle and bone tissue. Previous studies have demonstrated the role of VCP mutations in altering the ATPase activity of the D2 ring; however the structural consequences of these mutations remain unclear. In this study, we report the three-dimensional (3D) map of the pathogenic VCP variant, R155P, as revealed by single-particle Cryo-Electron Microscopy (EM) analysis at 14 Å resolution. We show that the N-terminal R155P mutation induces a large structural reorganisation of the D2 ATPase ring. Results from docking studies using crystal structure data of available wild-type VCP in the EM density maps indicate that the major difference is localized at the interface between two protomers within the D2 ring. Consistent with a conformational change, the VCP R155P variant shifted the isoelectric point of the protein and reduced its interaction with its well-characterized cofactor, nuclear protein localization-4 (Npl4). Together, our results demonstrate that a single amino acid substitution in the N-terminal domain can relay long-range conformational changes to the distal D2 ATPase ring. Our results provide the first structural clues of how VCP mutations may influence the activity and function of the D2 ATPase ring. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Cryo-EM of the pathogenic VCP variant R155P reveals long-range conformational changes in the D2 ATPase ring

    Energy Technology Data Exchange (ETDEWEB)

    Mountassif, Driss; Fabre, Lucien [Department of Anatomy and Cell Biology, McGill University, Groupe de recherche axé sur la structure des protéines (GRASP), Groupe d' Étude des Proteines Membranaires (GÉPROM), 3640 University Street, Montreal H3A 0C7 (Canada); Zaid, Younes [Department of Anatomy and Cell Biology, McGill University, Groupe de recherche axé sur la structure des protéines (GRASP), Groupe d' Étude des Proteines Membranaires (GÉPROM), 3640 University Street, Montreal H3A 0C7 (Canada); Current address: Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, Quebec (Canada); Halawani, Dalia [Department of Anatomy and Cell Biology, McGill University, Groupe de recherche axé sur la structure des protéines (GRASP), Groupe d' Étude des Proteines Membranaires (GÉPROM), 3640 University Street, Montreal H3A 0C7 (Canada); Current address: Department of Cell Biology, Lerner Research Institute, 9500 Euclid Avenue NC10, Cleveland, OH 44195 (United States); Rouiller, Isabelle, E-mail: isabelle.rouiller@mcgill.ca [Department of Anatomy and Cell Biology, McGill University, Groupe de recherche axé sur la structure des protéines (GRASP), Groupe d' Étude des Proteines Membranaires (GÉPROM), 3640 University Street, Montreal H3A 0C7 (Canada)

    2015-12-25

    Single amino acid mutations in valosin containing protein (VCP/p97), a highly conserved member of the ATPases associated with diverse cellular activities (AAA) family of ATPases has been linked to a severe degenerative disease affecting brain, muscle and bone tissue. Previous studies have demonstrated the role of VCP mutations in altering the ATPase activity of the D2 ring; however the structural consequences of these mutations remain unclear. In this study, we report the three-dimensional (3D) map of the pathogenic VCP variant, R155P, as revealed by single-particle Cryo-Electron Microscopy (EM) analysis at 14 Å resolution. We show that the N-terminal R155P mutation induces a large structural reorganisation of the D2 ATPase ring. Results from docking studies using crystal structure data of available wild-type VCP in the EM density maps indicate that the major difference is localized at the interface between two protomers within the D2 ring. Consistent with a conformational change, the VCP R155P variant shifted the isoelectric point of the protein and reduced its interaction with its well-characterized cofactor, nuclear protein localization-4 (Npl4). Together, our results demonstrate that a single amino acid substitution in the N-terminal domain can relay long-range conformational changes to the distal D2 ATPase ring. Our results provide the first structural clues of how VCP mutations may influence the activity and function of the D2 ATPase ring. - Highlights: • p97{sub R155P} and p97{sub A232E} decrease the ability of p97 to bind to its co-factor Npl4. • p97{sub R155P} has a different isoelectric point than that of p97{sub R95G}, p97{sub A232E} and p97{sub WT}. • Mutation R155P changes principally the conformation of the D2 ring. • Mutation R155P modifies the interface between two protomers within the D2 ring.

  10. Cryo-EM of the pathogenic VCP variant R155P reveals long-range conformational changes in the D2 ATPase ring

    International Nuclear Information System (INIS)

    Mountassif, Driss; Fabre, Lucien; Zaid, Younes; Halawani, Dalia; Rouiller, Isabelle

    2015-01-01

    Single amino acid mutations in valosin containing protein (VCP/p97), a highly conserved member of the ATPases associated with diverse cellular activities (AAA) family of ATPases has been linked to a severe degenerative disease affecting brain, muscle and bone tissue. Previous studies have demonstrated the role of VCP mutations in altering the ATPase activity of the D2 ring; however the structural consequences of these mutations remain unclear. In this study, we report the three-dimensional (3D) map of the pathogenic VCP variant, R155P, as revealed by single-particle Cryo-Electron Microscopy (EM) analysis at 14 Å resolution. We show that the N-terminal R155P mutation induces a large structural reorganisation of the D2 ATPase ring. Results from docking studies using crystal structure data of available wild-type VCP in the EM density maps indicate that the major difference is localized at the interface between two protomers within the D2 ring. Consistent with a conformational change, the VCP R155P variant shifted the isoelectric point of the protein and reduced its interaction with its well-characterized cofactor, nuclear protein localization-4 (Npl4). Together, our results demonstrate that a single amino acid substitution in the N-terminal domain can relay long-range conformational changes to the distal D2 ATPase ring. Our results provide the first structural clues of how VCP mutations may influence the activity and function of the D2 ATPase ring. - Highlights: • p97 R155P and p97 A232E decrease the ability of p97 to bind to its co-factor Npl4. • p97 R155P has a different isoelectric point than that of p97 R95G , p97 A232E and p97 WT . • Mutation R155P changes principally the conformation of the D2 ring. • Mutation R155P modifies the interface between two protomers within the D2 ring.

  11. Pilocytic astrocytoma following radiotherapy for craniopharyngioma: case report Astrocitoma pilocítico pós-radioterapia para tratamento de craniofaringioma: relato de caso

    Directory of Open Access Journals (Sweden)

    LEONARDO BONILHA

    2000-09-01

    Full Text Available Administration of fractionated doses of irradiation is part of the adjutant therapy for CNS tumours such as craniopharyngiomas and pituitary adenomas. It can maximise cure rates or expand symptom-free period. Among the adverse effects of radiotherapy, the induction of a new tumour within the irradiated field has been frequently described. The precise clinical features that correlate irradiation and oncogenesis are not completely defined, but some authors have suggested that tumors are radiation induced when they are histologically different from the treated ones, arise in greater frequency in irradiated patients than among normal population and tend to occur in younger people with an unusual aggressiveness. In this article, we report a case of a papillary astrocytoma arising in a rather unusual latency period following radiotherapy for craniopharyngioma.A administração de doses fracionadas de radiação é parte do tratamento adjuvante de tumores do sistema nervoso central como craniofaringiomas ou adenomas hipofisários. A radioterapia pode aumentar as chances de cura ou expandir o período livre de sintomas. Dentre seus efeitos adversos, é conhecida a possibilidade de aparecimento de novo tumor na região irradiada. Os critérios que definem se um novo tumor é de fato induzido por radiação ainda não são completamente definidos. Adimite-se, no entanto, que se o novo tumor é histologicamente diferente do primeiro, aparece em indivíduos mais jovens e é mais agressivo que o habitual, provavelmente sua origem é devida à oncogênese da irradiação. Descrevemos um caso de astrocitoma pilocítico possivelmente induzido por radioterapia, com surgimento em tempo de latência inesperadamente curto.

  12. Conformal Nets II: Conformal Blocks

    Science.gov (United States)

    Bartels, Arthur; Douglas, Christopher L.; Henriques, André

    2017-08-01

    Conformal nets provide a mathematical formalism for conformal field theory. Associated to a conformal net with finite index, we give a construction of the `bundle of conformal blocks', a representation of the mapping class groupoid of closed topological surfaces into the category of finite-dimensional projective Hilbert spaces. We also construct infinite-dimensional spaces of conformal blocks for topological surfaces with smooth boundary. We prove that the conformal blocks satisfy a factorization formula for gluing surfaces along circles, and an analogous formula for gluing surfaces along intervals. We use this interval factorization property to give a new proof of the modularity of the category of representations of a conformal net.

  13. Conformal house

    DEFF Research Database (Denmark)

    Ryttov, Thomas Aaby; Sannino, Francesco

    2010-01-01

    fixed point. As a consistency check we recover the previously investigated bounds of the conformal windows when restricting to a single matter representation. The earlier conformal windows can be imagined to be part now of the new conformal house. We predict the nonperturbative anomalous dimensions...... at the infrared fixed points. We further investigate the effects of adding mass terms to the condensates on the conformal house chiral dynamics and construct the simplest instanton induced effective Lagrangian terms...

  14. Transportation Conformity

    Science.gov (United States)

    This section provides information on: current laws, regulations and guidance, policy and technical guidance, project-level conformity, general information, contacts and training, adequacy review of SIP submissions

  15. Braquiterapia intersticial para recidivas de câncer de colo uterino pós-radioterapia

    OpenAIRE

    Oliveira,Antonio Carlos Zuliani de; Esteves,Sérgio Carlos Barros; Feijó,Luiz Fernando Andrade; Tagawa,Eduardo Komai; Cunha,Maércio de Oliveira

    2005-01-01

    OBJETIVO: Analisar a resposta e toxicidade da braquiterapia de alta taxa de dose (BATD) intersticial para carcinoma do colo do útero com recidiva pélvica pós-radioterapia. MATERIAIS E MÉTODOS: Entre 1998 e 2001, 11 pacientes com carcinoma de colo de útero e que tiveram recidiva pélvica pós-radioterapia receberam BATD intersticial. Idade: 41 a 71 anos (média: 56,5 anos); estádios (FIGO): IIA, IIB, IIIB e IVA. Nove (82%) pacientes tinham carcinoma de células escamosas e duas (18%), adenocarcino...

  16. Workers’ Conformism

    Directory of Open Access Journals (Sweden)

    Nikolay Ivantchev

    2013-10-01

    Full Text Available Conformism was studied among 46 workers with different kinds of occupations by means of two modified scales measuring conformity by Santor, Messervey, and Kusumakar (2000 – scale for perceived peer pressure and scale for conformism in antisocial situations. The hypothesis of the study that workers’ conformism is expressed in a medium degree was confirmed partly. More than a half of the workers conform in a medium degree for taking risk, and for the use of alcohol and drugs, and for sexual relationships. More than a half of the respondents conform in a small degree for anti-social activities (like a theft. The workers were more inclined to conform for risk taking (10.9%, then – for the use of alcohol, drugs and for sexual relationships (8.7%, and in the lowest degree – for anti-social activities (6.5%. The workers who were inclined for the use of alcohol and drugs tended also to conform for anti-social activities.

  17. Efecto de la radioterapia en glándulas salivales accesorias.

    OpenAIRE

    Pérez Fernández, Carmen Aránzazu

    2005-01-01

    RESUMEN El objetivo de este trabajo es estudiar las alteraciones que las radiaciones ionizantes producen sobre las glándulas salivales accesorias labiales. En nuestro estudio se seleccionaron sujetos diagnosticados de un tumor maligno de cabeza y cuello que iban a recibir radioterapia dentro de su tratamiento, incluyendo los labios dentro del campo de irradiación. Se evaluó la secreción salival y las alteraciones morfológicas de las glándulas en el momento del diagnóstico...

  18. Proyecto de blindaje de un acelerador de electrones con finalidad de radioterapia

    OpenAIRE

    Jiménez Gordon, David

    2010-01-01

    El presente proyecto pretende dar cobertura a la reciente revisión de las normativas vigentes (DIN 6847-2, septiembre de 2008 y NCRP Report nº 151, diciembre de 2005) sobre el blindaje de instalaciones de radioterapia equipadas con acelerador lineal. En estas instalaciones el blindaje constituye prácticamente el 100% de la obra civil del proyecto. En los últimos años, en España y a nivel mundial, se ha experimentado un gran aumento de las solicitudes de autorización de este tip...

  19. Significado prognóstico do linfonodo metastático N3 em carcinomas epidermóides de cabeça e pescoço

    Directory of Open Access Journals (Sweden)

    Ali Amar

    Full Text Available OBJETIVO: Avaliar os resultados do tratamento da doença metastática em estádio avançado (N3 e sua relação com o prognóstico do carcinoma espinocelular de cabeça e pescoço. MÉTODO: Foram revisados as informações de prontuários de 241 pacientes, com carcinoma espinocelular de boca, orofaringe, laringe e hipofaringe com metástases cervicais maiores que 6 cm (N3 submetidos à cirurgia e/ou radioterapia, no Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia do Hospital Heliópolis, Hosphel, São Paulo, de 1988 a 1998. Nos pacientes submetidos à cirurgia foi avaliada a radicalidade cirúrgica, macroscopicamente completa ou não, e naqueles tratados pela radioterapia, foi analisada a resposta do sítio primário e do pescoço imediatamente ao término do tratamento. A sobrevida livre de doença foi estimada pelo método de Kapplan Meier no grupo submetido à cirurgia. RESULTADOS: A irressecabilidade da lesão primária e metastática no pescoço justificou a indicação da radioterapia na dose média de 65 Gy, em 69 pacientes ocorrendo resposta completa no sítio primário em 24(36%, no pescoço em 12 (18%, e em ambos os sítios em 11 casos (16%. No grupo sumetido à cirurgia seguido de radioterapia, a dose média foi de 56 Gy. Dos 25 pacientes com ressecção macroscópica radical do pescoço, cinco (20% recidivaram, e dos cinco com ressecção incompleta e radioterapia, dois tiveram sobrevida de sete a 12 meses após o tratamento, quando foram perdidos de seguimento. A sobrevida livre de doença em dois anos neste grupo foi de 58%. CONCLUSÕES: Para pacientes com linfonodo metastático N3, o esvaziamento cervical seguido de radioterapia foi eficiente no controle regional da doença enquanto que nos inoperáveis, a radioterapia é um tratamento paliativo.

  20. Conformal Infinity

    Directory of Open Access Journals (Sweden)

    Frauendiener Jörg

    2000-08-01

    Full Text Available The notion of conformal infinity has a long history within the research in Einstein's theory of gravity. Today, ``conformal infinity'' is related with almost all other branches of research in general relativity, from quantisation procedures to abstract mathematical issues to numerical applications. This review article attempts to show how this concept gradually and inevitably evolved out of physical issues, namely the need to understand gravitational radiation and isolated systems within the theory of gravitation and how it lends itself very naturally to solve radiation problems in numerical relativity. The fundamental concept of null-infinity is introduced. Friedrich's regular conformal field equations are presented and various initial value problems for them are discussed. Finally, it is shown that the conformal field equations provide a very powerful method within numerical relativity to study global problems such as gravitational wave propagation and detection.

  1. Conformal Infinity.

    Science.gov (United States)

    Frauendiener, Jörg

    2004-01-01

    The notion of conformal infinity has a long history within the research in Einstein's theory of gravity. Today, "conformal infinity" is related to almost all other branches of research in general relativity, from quantisation procedures to abstract mathematical issues to numerical applications. This review article attempts to show how this concept gradually and inevitably evolved from physical issues, namely the need to understand gravitational radiation and isolated systems within the theory of gravitation, and how it lends itself very naturally to the solution of radiation problems in numerical relativity. The fundamental concept of null-infinity is introduced. Friedrich's regular conformal field equations are presented and various initial value problems for them are discussed. Finally, it is shown that the conformal field equations provide a very powerful method within numerical relativity to study global problems such as gravitational wave propagation and detection.

  2. Conformal Infinity

    Directory of Open Access Journals (Sweden)

    Frauendiener Jörg

    2004-01-01

    Full Text Available The notion of conformal infinity has a long history within the research in Einstein's theory of gravity. Today, 'conformal infinity' is related to almost all other branches of research in general relativity, from quantisation procedures to abstract mathematical issues to numerical applications. This review article attempts to show how this concept gradually and inevitably evolved from physical issues, namely the need to understand gravitational radiation and isolated systems within the theory of gravitation, and how it lends itself very naturally to the solution of radiation problems in numerical relativity. The fundamental concept of null-infinity is introduced. Friedrich's regular conformal field equations are presented and various initial value problems for them are discussed. Finally, it is shown that the conformal field equations provide a very powerful method within numerical relativity to study global problems such as gravitational wave propagation and detection.

  3. General Conformity

    Science.gov (United States)

    The General Conformity requirements ensure that the actions taken by federal agencies in nonattainment and maintenance areas do not interfere with a state’s plans to meet national standards for air quality.

  4. Conformal Infinity

    OpenAIRE

    Frauendiener, J?rg

    2000-01-01

    The notion of conformal infinity has a long history within the research in Einstein's theory of gravity. Today, 'conformal infinity' is related to almost all other branches of research in general relativity, from quantisation procedures to abstract mathematical issues to numerical applications. This review article attempts to show how this concept gradually and inevitably evolved from physical issues, namely the need to understand gravitational radiation and isolated systems within the theory...

  5. Conformation radiotherapy and conformal radiotherapy

    International Nuclear Information System (INIS)

    Morita, Kozo

    1999-01-01

    In order to coincide the high dose region to the target volume, the 'Conformation Radiotherapy Technique' using the multileaf collimator and the device for 'hollow-out technique' was developed by Prof. S. Takahashi in 1960. This technique can be classified a type of 2D-dynamic conformal RT techniques. By the clinical application of this technique, the late complications of the lens, the intestine and the urinary bladder after radiotherapy for the maxillary cancer and the cervical cancer decreased. Since 1980's the exact position and shape of the tumor and the surrounding normal tissues can be easily obtained by the tremendous development of the CT/MRI imaging technique. As a result, various kinds of new conformal techniques such as the 3D-CRT, the dose intensity modulation, the tomotherapy have been developed since the beginning of 1990'. Several 'dose escalation study with 2D-/3D conformal RT' is now under way to improve the treatment results. (author)

  6. Conformal Gravity

    International Nuclear Information System (INIS)

    Hooft, G.

    2012-01-01

    The dynamical degree of freedom for the gravitational force is the metric tensor, having 10 locally independent degrees of freedom (of which 4 can be used to fix the coordinate choice). In conformal gravity, we split this field into an overall scalar factor and a nine-component remainder. All unrenormalizable infinities are in this remainder, while the scalar component can be handled like any other scalar field such as the Higgs field. In this formalism, conformal symmetry is spontaneously broken. An imperative demand on any healthy quantum gravity theory is that black holes should be described as quantum systems with micro-states as dictated by the Hawking-Bekenstein theory. This requires conformal symmetry that may be broken spontaneously but not explicitly, and this means that all conformal anomalies must cancel out. Cancellation of conformal anomalies yields constraints on the matter sector as described by some universal field theory. Thus black hole physics may eventually be of help in the construction of unified field theories. (author)

  7. Radiotherapy in veterinary medicine: beginnings and perspectives; Radioterapia em medicina veterinaria: principios e perspectivas

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Marco A.R., E-mail: marco@cetea.com.b [Universidade Estadual Paulista Julio de Mesquisa Filho (UNESP), Botucatu, SP (Brazil). Fac. de Medicina. Dept. de Dermatologia e Radioterapia; Andrade, Alexandre L.; Luvizoto, Maria C.R.; Piero, Juliana R.; Ciarlini, Luciana D.R.P. [UNESP, Aracatuba, SP (Brazil). Dept. de Clinica Animal. Curso de Medicina Veterinaria

    2010-06-15

    This work presents a brief historical about the use of ionizing radiations in Veterinary Medicine, instructing the physical beginnings and techniques wrapped in the realization of the proceedings of radiotherapy in animals, illustrating some treated cases, highlighting the difficulties and pointing to the perspectives and importance of the acting of the medical physics in this kind of therapeutic still little used in the national scenery. (author)

  8. Nutritional assistance to patients during radiotherapy; Acompanhamento nutricional de pacientes em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Dias, Maria C.G.; Nadalin, Wladimir; Baxter, Yara C.; Faintuch, Joel; Waitzberg, Dan L.; Maculevicius, Janete [Sao Paulo Univ., SP (Brazil). Hospital das Clinicas. Instituto Central e de Radiologia

    1996-03-01

    With the aim of assessing the possible benefits of nutritional therapy , 140 patients were prospectively studied during radiotherapy of the head and neck (81%) and esophageal cancer (19%). Mean age was 56.0 (17-80), with 114 males and 26 females. Duration of both nutrition and radiotherapy was 78.0 {+-} 45 days. Tube feeding was the primary modality in 50.7% of the population, and oral regimens in the remaining 49.3%, but associations between the methods were also used. Enteral diets were supplied under the supervision of a specialized tem for home alimentation (PROSNED). Compliance to the program was 100% and a lymphocyte count diminished along this period (1933 {+-} 1033 vs 1265 {+-} 688, p.0.001). A subjective improvement was reported by 84% of the population, and total calorie intake, that was below 60% of estimated needs in 100% of the cases initially, significantly improved to just 40% inadequate at the end of the observations. Radiotherapy was associated with mucositis in 21% of the patients, taste changes in 79%, xerostomy in 81%, anorexia in 66% and odinophagia in 59%. In the individuals selected for enteral feeding, side effects were represented by technical problems (20%) and gastrointestinal disorders (13%). All patients completed the nutritional support program and there was no mortality in this series. It is conclude that: early nutritional support during radiotherapy was able to maintain or improve the nutritional status; tube feeding, alone or in combination with oral diets, was indicated whenever appropriate and contributed to fulfillment of the energy requirements; reduction of total lymphocytes could not be prevented by the mentioned therapy; complications of enteral alimentation were mild and affected a small proportion of the population; troubles induced by radiotherapy were as frequent as expected, and tended to disturb the intake of the food; the compliance of the therapeutic plan was excellent and can be attributed to the efforts of the multidisciplinary team as well to the help of the specialized home alimentation unit (PROSNED). (author). 40 refs., 6 figs., 1 tab.

  9. Fertilidade de fêmeas Nelore após inseminação artificial em tempo fixo conforme a contagem de folículos antrais

    Directory of Open Access Journals (Sweden)

    Alexandra Soares Rodrigues

    2013-07-01

    Full Text Available O objetivo deste trabalho foi determinar o efeito do número de folículos antrais sobre as taxas de concepção de fêmeas Nelore, em programa de inseminação artificial em tempo fixo (IATF. Para isso, 481 fêmeas foram submetidas a um protocolo de IATF e avaliadas quanto à contagem de folículos antrais (CFA e ao diagnóstico de gestação. Os animais foram agrupados nas categorias de CFA baixa (53. Não houve diferença entre as taxas de concepção obtidas nas categorias de CFA em IATF com uso de gonadotrofina coriônica.

  10. Minimal requirements for quality controls in radiotherapy with external beams; Controlli di qualita' essenziali in radioterapia con fasci esterni

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    Physical dosimetric guidelines have been developed by the Italian National Institute of Health study group on quality assurance in radiotherapy to define protocols for quality controls in external beam radiotherapy. While the document does not determine strict rules or firm recommendations, it suggests minimal requirements for quality controls necessary to guarantee an adequate degree of accuracy in external beam radiotherapy. [Italian] Il gruppo di studio Assicurazione di qualita' in radioterapia dell'Istituto Superiore di Sanita' presenta le linee guida per la stesura dei protocolli di controllo di qualita' essenziali necessari a garantire un adeguato livello di accuratezza del trattamento radiante e rappresenta pertanto una parte essenziale del contributo fisico-dosimetrico globale di assicurazione di qualita' in radioterapia con fasci esterni.

  11. Conformality lost

    International Nuclear Information System (INIS)

    Kaplan, David B.; Lee, Jong-Wan; Son, Dam T.; Stephanov, Mikhail A.

    2009-01-01

    We consider zero-temperature transitions from conformal to nonconformal phases in quantum theories. We argue that there are three generic mechanisms for the loss of conformality in any number of dimensions: (i) fixed point goes to zero coupling, (ii) fixed point runs off to infinite coupling, or (iii) an IR fixed point annihilates with a UV fixed point and they both disappear into the complex plane. We give both relativistic and nonrelativistic examples of the last case in various dimensions and show that the critical behavior of the mass gap behaves similarly to the correlation length in the finite temperature Berezinskii-Kosterlitz-Thouless (BKT) phase transition in two dimensions, ξ∼exp(c/|T-T c | 1/2 ). We speculate that the chiral phase transition in QCD at large number of fermion flavors belongs to this universality class, and attempt to identify the UV fixed point that annihilates with the Banks-Zaks fixed point at the lower end of the conformal window.

  12. Análise videolaringoestroboscópica de pacientes submetidos à radioterapia para tratamento de câncer glótico Videolaryngostroboscopic analysis of patients submitted to radiation therapy for the treatment of glottic cancer

    Directory of Open Access Journals (Sweden)

    André Luís Quarteiro

    2010-02-01

    Full Text Available Sendo a radioterapia oncologicamente adequada no tratamento do câncer precoce da laringe, é importante estudar o padrão vibratório, que é componente crítico para os resultados vocais. OBJETIVO: Analisar os achados videolaringoestroboscópicos em um grupo de pacientes submetidos à radioterapia para o tratamento do câncer glótico precoce. MÉTODOS: Estudo retrospectivo realizado através da avaliação de 20 pacientes estadiados como T1a glótico de 1995 a 2005. Um protocolo videolaringoestroboscópico foi aplicado. RESULTADOS: O fechamento glótico foi completo em 17 pacientes. A amplitude foi normal em 14 pregas vocais tratadas e em 18 pregas contralaterais. O padrão da onda vibratória mucosa foi sempre totalmente presente, normal ou discretamente diminuído em ambas as pregas vocais, com melhores resultados para a prega vocal contralateral em comparação com aqueles verificados nas pregas vocais com o tumor. A periodicidade foi sempre regular em todos os casos. A simetria e os movimentos das pregas vestibulares e das aritenoides foram normais. Houve constrição supraglótica lateral ocasional em quatro casos. O aspecto da mucosa foi edematoso em seis pacientes. Formação de bola de muco foi observada em 12 pacientes. CONCLUSÕES: O padrão vibratório foi normal ou discretamente diminuído para ambas as pregas vocais após tratamento radioterápico para câncer glótico T1a.Radiation therapy is an adequate treatment for early laryngeal cancer, and it is important to study the vocal fold vibratory pattern, which is essential for a favorable voice outcome. AIM: To analyze laryngostroboscopic findings in a group of patients who underwent radiation therapy for the treatment of early glottic cancer. METHODS: A retrospective study was conducted in order to evaluate 20 patients staged as T1a glottic tumors in the period from 1995 to 2005. A laryngostroboscopic protocol was applied. RESULTS: Glottic closure was complete in 17 patients

  13. Complicaciones orales en pacientes sometidos a radioterapia: revisión de literatura / Oral Complications in Patients Undergoing Radiotherapy: A Review of Literature

    OpenAIRE

    Hurtado Redondo, Diana Carolina; Universidad Nacional de Colombia sede Bogotá; Estrada Montoya, John Harold; Universidad Nacional de Colombia sede Bogotá

    2013-01-01

    Objetivo: Presentar los principales conceptos de radiobiología, radioterapia en cavidadoral y complicaciones asociadas, para llevar a cabo acciones seguras de tipo preventivo yterapéutico por parte del profesional o del equipo tratante. Método: La revisión se llevó acabo en diferentes bases de datos y revistas acerca del manejo odontológico de pacientessometidos a radioterapia. Resultados: Actualmente, el tratamiento para el cáncer tiene unenfoque multidisciplinario, en el cual participan dis...

  14. Ansiedad y depresión en mujeres con cáncer de mama en radioterapia: Prevalencia y factores asociados

    OpenAIRE

    Ornelas-Mejorada,Rosa Elena; Tufiño Tufiño,Mónica Anahí; Sánchez-Sosa,Juan José

    2011-01-01

    Someterse a radioterapia y padecer los efectos secundarios son situaciones que generan ansiedad y depresión en las mujeres con cáncer de mama. El objetivo fue evaluar la prevalencia de ansiedad y depresión que presentan las mujeres con cáncer de mama en radioterapia y analizar los efectos y las diferencias de variables clínicas y sociodemográficas sobre su malestar psicológico. Participaron 203 mujeres mexicanas con cáncer de mama en estadios 0-III. Para evaluar ansiedad y depresión se utiliz...

  15. Conformal Tachyons

    CERN Document Server

    Tomaschitz, R

    2000-01-01

    We study tachyons conformally coupled to the background geometry of a Milne universe. The causality of superluminal signal transfer is scrutinized in this context. The cosmic time of the comoving frame determines a distinguished time order for events connected by superluminal signals. An observer can relate his rest frame to the galaxy frame, and compare so the time order of events in his proper time to the cosmic time order. All observers can in this way arrive at identical conclusions on the causality of events connected by superluminal signals. An unambiguous energy concept for tachyonic rays is defined by means of the cosmic time of the comoving reference frame, without resorting to an antiparticle interpretation. On that basis we give an explicit proof that no signals can be sent into the past of observers. Causality violating signals are energetically forbidden, as they would have negative energy in the rest frame of the emitting observer. If an observer emits a superluminal signal, the tachyonic respon...

  16. Normal tissue complications after radiation therapy Las complicaciones de la radioterapia en los tejidos sanos

    Directory of Open Access Journals (Sweden)

    Jolyon H. Hendry

    2006-09-01

    Full Text Available This paper describes the biological mechanisms of normal tissue reactions after radiation therapy, with reference to conventional treatments, new treatments, and treatments in developing countries. It also describes biological reasons for the latency period before tissue complications arise, the relationship of dose to incidence, the effect of increasing the size of the irradiated volume, early and late tissue reactions, effects of changes in dose fractionation and dose rate, and combined chemotherapy and radiotherapy responses. Examples are given of increases in knowledge of clinical radiobiology from trials of new protocols. Potential modification to treatments include the use of biological response modifiers. The introduction of "response prediction" modifications to treatments might also be available in the near future. Finally, the paper points out that in some radiotherapy centers, the biologically-effective doses prescribed for combined brachytherapy and teletherapy treatment of cervix cancer are lower than those prescribed in other centers. This issue needs to be addressed further. The wealth of preclinical and clinical data has led to a much greater understanding of the biological basis to radiotherapy. This understanding has underpinned a variety of new approaches in radiotherapy, including both physical and biological strategies. There is also the important issue of treatment of a large number of cancers in developing countries, for which efficacious resource-sparing protocols are being continuously developed. A unified scoring system should be widely accepted as the new standard in reporting the adverse effects of radiation therapy. Likewise, late toxicity should be reported on an actuarial basis as a mandatory endpoint.En este artículo se describen los mecanismos biológicos que intervienen en las reacciones provocadas por la radioterapia, tanto con tratamientos convencionales como con los más nuevos, y los aplicados en países en

  17. Conformal field theory in conformal space

    International Nuclear Information System (INIS)

    Preitschopf, C.R.; Vasiliev, M.A.

    1999-01-01

    We present a new framework for a Lagrangian description of conformal field theories in various dimensions based on a local version of d + 2-dimensional conformal space. The results include a true gauge theory of conformal gravity in d = (1, 3) and any standard matter coupled to it. An important feature is the automatic derivation of the conformal gravity constraints, which are necessary for the analysis of the matter systems

  18. Tratamiento del cáncer de cabeza y cuello en estadio avanzado inoperable mediante quimioterapia intraarterial y radioterapia concomitante

    OpenAIRE

    García Sevilla, Alba

    2017-01-01

    La quimioterapia intraarterial y radioterapia concomitante fue descrita por Robbins en 1994 en el tratamiento de pacientes con tumores irresecables de cabeza y cuello, consistiendo en una infusión supraselectiva intraarterial de cisplatino en la arteria nutricia del tumor y una infusión sistémica de tiosulfato sódico, un agente quelante que protege al resto del organismo de la toxicidad del cisplatino. Se consigue una dosis alta del quimioterápico en la zona tumoral minimizando los efectos tó...

  19. A profissão de músico conforme apresentada em jornais paraibanos The profession of musician in the paraíba state newspapers

    Directory of Open Access Journals (Sweden)

    Sandra Souza

    2010-04-01

    Full Text Available O artigo relata estudo sobre a profissão dos músicos na Paraíba, realizado por meio da aplicação da análise de conteúdo de dois jornais diários do Estado. A referida análise foi desenvolvida com uma amostra de números referentes aos anos de 2001 e 2003. Identificaram-se quatro categorias (papel social da música; incentivo à música; profissão e organização político-associativas. Tal estudo empírico resultou na identificação de aspectos centrais e importantes na construção da identidade profissional, como: o profissionalismo versus amadorismo; o mito da fama versus o anonimato; desvalorização da chamada prata da casa versus valorização do estrangeiro, etc. Embora não esgotem o tema, situam o lugar que a profissão ocupa na sociedade e pode se constituir em fonte para a elaboração de novas questões e hipóteses para os pesquisadores que se interessarem pela temática.The article reports study on the profession of musicians in the State of Paraíba, conducted by applying the analysis of contents of two daily newspapers of the State. The analysis itself was developed with a sample of issues of the years 2001 and 2003. Four categories were identified (social role of the music; encouraging the music; profession and associative political organization. Such empirical study resulted in the identification of key and important aspects, in the construction of a professional identity, as, professionalism versus amateurism; the myth of fame versus the anonymity; the depreciation of the so-called home talent versus the value of the foreign ones, and so on. Even though this type of media does not exhaust the subject, it establishes the position that the profession occupies in the society and may constitute itself a source for the development of new questions and hypotheses for the researchers interested in the topic.

  20. QUALIDADE DA ÁGUA DE CHUVA EM JOÃO PESSOA: ESTUDO COMPARATIVO COM DIVERSOS PADRÕES DE QUALIDADE CONFORME OS USOS PRETENDIDOS PARA ÁGUA EM EDIFICAÇÕES RESIDENCIAIS

    Directory of Open Access Journals (Sweden)

    Ysa Helena Diniz Morais de Luna

    2014-08-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 Com este artigo, estudou-se a qualidade da água de chuva em um sistema instalado na cidade de João Pessoa-PB, tendo como objetivo verificar sua adequabilidade para usos residenciais. Utilizou-se como padrões comparativos de qualidade os descritos em NBR 15527/2007 (ABNT, 2007, NBR 13969/1997 (ABNT, 1997, Sautchunk et al. (2005, Resolução CONAMA 357/2005 (BRASIL, 2005 e Portaria MS 2914/2011 (BRASIL, 2011. Foram testados dois mecanismos de melhoria da qualidade da água, a saber: dispositivos de descarte dos primeiros milímetros de chuva e filtro de areia. Os resultados mostraram que a qualidade da água, seja a bruta, antes de contato com a superfície de captação, seja a armazenada no reservatório, apresenta boa qualidade, compatível com diversos usos previstos em uma residência, tais como: descargas de bacias sanitárias, irrigação de gramado e de plantas ornamentais, lavagem de veículos e limpeza de calçadas e ruas. Verificou-se, também, o atendimento aos padrões da Resolução CONAMA 357 (BRASIL, 2005 classe 1 que se destina, dentre outros usos, ao abastecimento humano após tratamento simplificado. Com relação aos padrões de potabilidade, preconizados pela Portaria MS 2914/2011 (BRASIL, 2011, ocorreram apenas quatro casos de não atendimento para a turbidez e o não-atendimento para todos os casos referentes a coliformes totais e termotolerantes. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}

  1. Deglutição após quimioterapia e radioterapia simultânea para carcinomas de laringe e hipofaringe Swallowing after chemotherapy and radiotherapy for laryngeal and hypopharyngeal carcinomas

    Directory of Open Access Journals (Sweden)

    Andréa Bizarria Cintra

    2005-04-01

    Full Text Available OBJETIVO: Avaliar a deglutição orofaríngea de pacientes submetidos a protocolo de preservação de laringe no Hospital do Câncer AC Camargo. MÉTODOS: De 43 pacientes com carcinoma epidermóide de laringe e hipofaringe tratados com quimioterapia semanal (paclitaxel 30 mg/m² e cisplatina 20 mg/m² concomitante à radioterapia externa fracionada (180 cGy/dia, dose total 7040 cGy, foram avaliados 31 pacientes. A avaliação consistiu de videofluoroscopia. Os resultados foram classificados de acordo com alterações de motilidade orofaríngea, estases, aspiração e severidade da disfagia. RESULTADOS: alterações de fase preparatória e oral: estase em cavidade oral (58% e aumento do tempo de trânsito oral (32,3%; fase faríngea: estase em valécula (83,9%, redução da elevação laríngea (74,2%, atraso no início da deglutição faríngea (51,6% e estase em hipofaringe (45,2%. A deglutição funcional foi observada em 35,5% dos pacientes, 54,8% tinham disfagias discretas ou moderadas e 9,6% disfagias severas. CONCLUSÃO: A associação de quimioterapia e radioterapia para preservação laríngea resulta em alterações da deglutição, na maior parte discretas a moderadas. Alguns pacientes, entretanto, evoluem com disfagia severa, em que a alimentação por via oral não é possível.The main goals of the larynx preservation protocol are eradication of cancer and preservation of a functional larynx with maintenance of respiration, phonation and swallowing. Few studies, however have addressed functional outcomes. OBJECTIVE: Functional evaluation of oropharyngeal swallowing in patients enrolled in a larynx preservation protocol at the Hospital do Câncer AC Camargo. METHODS: Evaluation of swallowing was performed by videofluoroscopy in 31 patients, focusing on: oropharyngeal motility disorders, stasis, laryngeal penetration, aspiration and severity of dysphagia. RESULTS: Swallowing analysis: 5 patients showed inefficient bolus preparation

  2. Conformidade de acessos e de saídas de postos de operação em tratores agrícolas segundo norma NBR/ISO 4252 Conformity of the accesses and exits of agricultural tractors workplaces according to NBR/ISO 4252 STANDARD

    Directory of Open Access Journals (Sweden)

    Danielle M. P. Mattar

    2010-02-01

    Full Text Available Este trabalho teve como objetivo avaliar a conformidade dos acessos e de saídas dos postos de operação em tratores agrícolas, por meio de população amostral dos tratores fabricados no Brasil. Para a avaliação, diversos itens referentes aos acessos e às saídas dos postos de operação foram analisados qualitativa e quantitativamente com base nos padrões da Norma NBR/ISO 4252. Ao final do trabalho, foi observado que os tratores classificados na Classe III, quanto à potência nominal do motor, atendem ao maior número de requisitos da Norma em comparação a tratores da Classe II. Dentre os itens avaliados, a altura da plataforma até o teto dos postos de operação foi atendida por todos os modelos. As presenças de batentes de proteção sobre os degraus e de corrimão para o operador foram os itens em maior desconformidade sobre os tratores. Como resultado médio, a população amostral foi conforme em 66% dos itens analisados. Os tratores dotados de motores de maior potência apresentaram, em geral, acessos e saídas dos postos de operação mais ergonômicos e seguros. De maneira geral, conclui-se pela baixa conformidade dos itens de ergonomia e de segurança dispostos ao operador sobre os postos de operação em tratores agrícolas nacionais.This work had as objective to evaluate the conformity of agricultural tractors workplaces accesses and exits made in Brazil. For this evaluation, the workplaces were analyzed according to NBR/ISO 4252 Standard. It was observed that the tractors classified in Class III, in relation to power engine, was better then tractors in Class II. Among the parameters evaluated, the platform weight of operator workplace was attended by all the tractors. The items in less conformoty in agricultural tractors are the doorpost of protection on the steps and the handrail to the operator. As results, the sampling population was conformed in 66% of the analyzed items. The tractors with more powerful engines

  3. Viscous conformal gauge theories

    DEFF Research Database (Denmark)

    Toniato, Arianna; Sannino, Francesco; Rischke, Dirk H.

    2017-01-01

    We present the conformal behavior of the shear viscosity-to-entropy density ratio and the fermion-number diffusion coefficient within the perturbative regime of the conformal window for gauge-fermion theories.......We present the conformal behavior of the shear viscosity-to-entropy density ratio and the fermion-number diffusion coefficient within the perturbative regime of the conformal window for gauge-fermion theories....

  4. Conformal Einstein spaces

    International Nuclear Information System (INIS)

    Kozameh, C.N.; Newman, E.T.; Tod, K.P.

    1985-01-01

    Conformal transformations in four-dimensional. In particular, a new set of two necessary and sufficient conditions for a space to be conformal to an Einstein space is presented. The first condition defines the class of spaces conformal to C spaces, whereas the last one (the vanishing of the Bach tensor) gives the particular subclass of C spaces which are conformally related to Einstein spaces. (author)

  5. Superspace conformal field theory

    Energy Technology Data Exchange (ETDEWEB)

    Quella, Thomas [Koeln Univ. (Germany). Inst. fuer Theoretische Physik; Schomerus, Volker [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2013-07-15

    Conformal sigma models and WZW models on coset superspaces provide important examples of logarithmic conformal field theories. They possess many applications to problems in string and condensed matter theory. We review recent results and developments, including the general construction of WZW models on type I supergroups, the classification of conformal sigma models and their embedding into string theory.

  6. Superspace conformal field theory

    International Nuclear Information System (INIS)

    Quella, Thomas

    2013-07-01

    Conformal sigma models and WZW models on coset superspaces provide important examples of logarithmic conformal field theories. They possess many applications to problems in string and condensed matter theory. We review recent results and developments, including the general construction of WZW models on type I supergroups, the classification of conformal sigma models and their embedding into string theory.

  7. Tratamiento de algunas dermatosis por los rayos X de bucky: desarrollo histórico de la radioterapia superficial

    Directory of Open Access Journals (Sweden)

    Gonzalo Reyes Garcia

    1940-11-01

    En los primeros años la Roentgenterapia, puso todo su interés en las reacciones cutáneas. Hasta el año de 1902, se trataron únicamente afecciones de la piel, sin buscar ningún efecto sobre los órganos profundos. Más tarde, Sinns, hacía publicaciones sobre la influencia de los rayos en la leucemia y poco a poco, con el perfeccionamiento de los aparatos y el aumento del voltaje, se fue desarrollando la radioterapia profunda, sobre todo en las afecciones cancerosas y otras de los órganos situados profunda mente; al mismo tiempo, se fueron fijando las técnicas y aplicaciones de la terapia superficial y se observaban las lesiones producidas por los rayos en la piel, tales como: atrofias, telangiectasis, úlceras renguenianas, eritemas, pigmentaciones, etc.

  8. Desenvolvimento puberal em meninas tratadas de LLA

    Directory of Open Access Journals (Sweden)

    Monteiro I.M.M.

    1998-01-01

    Full Text Available OBJETIVO: Com o objetivo de avaliar o desenvolvimento puberal após o tratamento de leucemia linfóide aguda (LLA na infância, foi realizado um estudo retrospectivo, em meninas tratadas de janeiro de 1980 a janeiro de 1991, no Centro de Investigações Hematológicas "Dr. Domingos A. Boldrini", em Campinas-SP. CASUÍSTICA E MÉTODO: Foram selecionadas 42 meninas, tratadas antes da puberdade com quimioterapia sistêmica e intratecal e radioterapia cranial, utilizando doses de 18 ou 24 Grays (Gy. RESULTADOS: As idades médias da telarca, pubarca e menarca foram inferiores às do grupo-controle, embora com significância estatística apenas para a idade da telarca. Não houve diferenças entre os grupos tratados com 18 ou 24Gy. As meninas tratadas antes dos cinco anos de idade apresentaram idade média da menarca estatisticamente inferior àquelas tratadas após cinco anos e em relação ao grupo-controle. CONCLUSÃO: Os resultados mostraram que o desenvolvimento puberal em meninas tratadas de LLA na infância foi mais precoce que o de meninas saudáveis.

  9. Quality controls in radiotherapy. From experiences of the first course-debate; Controlli di qualita' in radioterapia. Dalle esperienze del primo corso-dibattito

    Energy Technology Data Exchange (ETDEWEB)

    Rosi, A.; Viti, V. [Istituto Superiore di Sanita' , Laboratorio di Fisica, Rome (Italy)

    2000-07-01

    The document reports the main issues discussed during the first course-debate on quality controls in radiotherapy, held in Rome in December 3-4, 1998 and May 3-5 1999 in collaboration between the Istituto Superiore di Sanita' and the Istituto Regina Elena. The points considered critical to the quality assurance in radiotherapy by the participants are presented in relation to the total radiotherapy procedure. [Italian] Questo documento e' dedicato al primo corso-dibattito sui controlli di qualita' in radioterapia svoltosi a Roma il 3-4 dicembre 1998 e il 3-5 maggio 1999 in collaborazione tra l'Istituto Superiore di Sanita' e l'Istituto Regina Elena. Esso presenta gli argomenti ritenuti critici per l'assicurazione di qualita' in radioterapia in relazione all'intera procedura radioterapica, in base alle esperienze dei partecipanti.

  10. Quality controls in radiotherapy. From experiences of the first course-debate; Controlli di qualita' in radioterapia. Dalle esperienze del primo corso-dibattito

    Energy Technology Data Exchange (ETDEWEB)

    Rosi, A; Viti, V [Istituto Superiore di Sanita' , Laboratorio di Fisica, Rome (Italy)

    2000-07-01

    The document reports the main issues discussed during the first course-debate on quality controls in radiotherapy, held in Rome in December 3-4, 1998 and May 3-5 1999 in collaboration between the Istituto Superiore di Sanita' and the Istituto Regina Elena. The points considered critical to the quality assurance in radiotherapy by the participants are presented in relation to the total radiotherapy procedure. [Italian] Questo documento e' dedicato al primo corso-dibattito sui controlli di qualita' in radioterapia svoltosi a Roma il 3-4 dicembre 1998 e il 3-5 maggio 1999 in collaborazione tra l'Istituto Superiore di Sanita' e l'Istituto Regina Elena. Esso presenta gli argomenti ritenuti critici per l'assicurazione di qualita' in radioterapia in relazione all'intera procedura radioterapica, in base alle esperienze dei partecipanti.

  11. Minimal requirements for quality controls in radiotherapy with external beams; Controlli di qualita' essenziali in radioterapia con fasci esterni

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    Physical dosimetric guidelines have been developed by the Italian National Institute of Health study group on quality assurance in radiotherapy to define protocols for quality controls in external beam radiotherapy. While the document does not determine strict rules or firm recommendations, it suggests minimal requirements for quality controls necessary to guarantee an adequate degree of accuracy in external beam radiotherapy. [Italian] Il gruppo di studio Assicurazione di qualita' in radioterapia dell'Istituto Superiore di Sanita' presenta le linee guida per la stesura dei protocolli di controllo di qualita' essenziali necessari a garantire un adeguato livello di accuratezza del trattamento radiante e rappresenta pertanto una parte essenziale del contributo fisico-dosimetrico globale di assicurazione di qualita' in radioterapia con fasci esterni.

  12. Non-conformable, partial and conformable transposition

    DEFF Research Database (Denmark)

    König, Thomas; Mäder, Lars Kai

    2013-01-01

    and the Commission regarding a directive’s outcome, play a much more strategic role than has to date acknowledged in the transposition literature. Whereas disagreement of a member state delays conformable transposition, it speeds up non-conformable transposition. Disagreement of the Commission only prolongs...... the transposition process. We therefore conclude that a stronger focus on an effective sanctioning mechanism is warranted for safeguarding compliance with directives....

  13. Progressive pituitary hormone deficiency following radiation therapy in adults; Deficiencia progressiva dos hormonios adeno-hipofisarios apos radioterapia em adultos

    Energy Technology Data Exchange (ETDEWEB)

    Loureiro, Rafaela A.; Vaisman, Mario [Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, RJ (Brazil). Servico de Endocrinologia]. E-mail: rafaela_loureiro@hotmail.com

    2004-10-01

    Hypopituitarism can be caused by radiation therapy, even when it is not directly applied on the hypothalamic-pituitary axis, and can lead to anterior pituitary deficiency mainly due to hypothalamic damage. The progressive loss of the anterior pituitary hormones usually occurs in the following order: growth hormone, gonadotropin hormones, adrenocorticotropic hormone and thyroid-stimulating hormone. Although there are several different tests available to confirm anterior pituitary deficiency, this paper will focus on the gold standard tests for patients submitted to radiation therapy. We emphasize that the decline of anterior pituitary function is time- and dose-dependent with some variability among the different axes. Therefore, awareness of the need of a joint management by endocrinologists and oncologists is essential to improve treatment and quality of life of the patients. (author)

  14. Radiotherapy of the cephalic segment in patients with advanced neuroblastoma; Radioterapia do segmento cefalico em pacientes portadores de neuroblastoma avancado

    Energy Technology Data Exchange (ETDEWEB)

    Weltman, Eduardo

    1995-07-01

    Although the treatment results have significantly improved for several pediatric malignant neoplasms, particularly Wilms's tumor, lymphomas and leukemia, in the last decade, the prognosis of the INSS, stage 4 neuroblastoma over one year one old patients remains poor. Even for the more advanced centers, using the more aggressive treatment schedules, such as bone marrow transplantation, the probability of a 2 year progression free interval varies from 6 to 50% and at 3 to 6 years, from 13 to 54%. Thereby, at least, 46 to 94% of these patients are expected to die due to the merciless neoplasm progression. The hypothesis here to be tested is regarding the impact of the cephalic irradiation on the outcome of stage 4 patients with skull metastasis at diagnosis. The end point was to establish, under the NEURO-III-85 protocol chemotherapy schedule, the possible benefit of this radiotherapy in preventing the cephalic recurrence, and its reflex on these patients total and diseases free survival. These results disclosed that the cephalic segment irradiation may prevent recurrences at this site. Unfortunately, the decrease in the cranial recurrence frequency did not affect either the disease free interval, or the total survival. The conclusion was that cephalic irradiation have the potential of avoiding these recurrences, without modifying the final outcome. This modality of radiotherapy must be reevaluated under more effective systemic treatments. (author)

  15. Imagem guida em radioterapia com utilização de uma imagem volumétrica de raios

    OpenAIRE

    Monsanto, Fátima; Cardoso, Daniela; Coelho, Carina Marques; Sá, Ana Cravo; Miguel, Carla; Machado, Carlos

    2010-01-01

    Com este estudo pretende-se determinar com que estas verificações devem ser realizadas, de modo a minorar erros e incertezas de posicionamento e localização dos volumes alvo e de risco, nomeadamente o recto e a bexiga. Pretende-se também avaliar o volume e posição dos órgãos de risco.

  16. Comparison of methods for prioritizing risk in radiation oncology; Comparacao entre metodos de priorizacao de riscos em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Biazoto, Bruna; Tokarski, Marcio, E-mail: bruna@ceb.unicamp.br [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Centro de Engenharia Biomedica

    2016-07-01

    Proactive risk management tools, such as Failure Mode and Effect Analysis (FEMA), were imported from engineering and have been widely used in Radiation Oncology. An important step in this process is the risk prioritization and there are many methods to do that. This paper compares the risk prioritization of computerized planning phase in interstitial implants with high dose rate brachytherapy performed with Health Care Failure Mode and Effect Analysis (HFMEA) and FMEA with guidelines given by the Task Group 100 (TG 100) of the American Association of Physicists in Medicine. Out of the 33 possible failure modes of this process, 21 require more attention when evaluated by HFMEA and 22, when evaluated by FMEA TG 100. Despite the high coincidence between the methods, the execution of HFMEA was simpler. (author)

  17. Radiotherapy of the cephalic segment in patients with advanced neuroblastoma; Radioterapia do segmento cefalico em pacientes portadores de neuroblastoma avancado

    Energy Technology Data Exchange (ETDEWEB)

    Weltman, Eduardo

    1995-07-01

    Although the treatment results have significantly improved for several pediatric malignant neoplasms, particularly Wilms's tumor, lymphomas and leukemia, in the last decade, the prognosis of the INSS, stage 4 neuroblastoma over one year one old patients remains poor. Even for the more advanced centers, using the more aggressive treatment schedules, such as bone marrow transplantation, the probability of a 2 year progression free interval varies from 6 to 50% and at 3 to 6 years, from 13 to 54%. Thereby, at least, 46 to 94% of these patients are expected to die due to the merciless neoplasm progression. The hypothesis here to be tested is regarding the impact of the cephalic irradiation on the outcome of stage 4 patients with skull metastasis at diagnosis. The end point was to establish, under the NEURO-III-85 protocol chemotherapy schedule, the possible benefit of this radiotherapy in preventing the cephalic recurrence, and its reflex on these patients total and diseases free survival. These results disclosed that the cephalic segment irradiation may prevent recurrences at this site. Unfortunately, the decrease in the cranial recurrence frequency did not affect either the disease free interval, or the total survival. The conclusion was that cephalic irradiation have the potential of avoiding these recurrences, without modifying the final outcome. This modality of radiotherapy must be reevaluated under more effective systemic treatments. (author)

  18. A verification methodology for in vivo dosimetry in stereotactic radiotherapy; Uma metodologia para verificacao dosimetrica in vivo em radioterapia estereotaxica

    Energy Technology Data Exchange (ETDEWEB)

    Amaral, Leonardo L.; Oliveira, Harley F.; Fairbanks, Leandro R., E-mail: leonardo.fis@usp.br [Universidade de Sao Paulo (HCFMRP/USP), Ribeirao Preto, SP (Brazil). Faculdade de Medicina. Hospital das Clinicas; Nicolucci, Patricia; Netto, Thomaz G. [Universidade de Sao Paulo (FFCLRP/USP), Ribeirao Preto, SP (Brazil). Faculdade de Filosofia, Ciencias e Letras. Departamento de Fisica

    2012-12-15

    Radiotherapy of brain lesions near critical structures requires a high accuracy in the location and dose. The high precision is achieved by the location of the stereotactic apparatus. The accuracy in dose delivery should be accompanied by an accurate quality control in devices that involve the practice, however, still does not guarantee the dose at the time of therapy. The large number of fields and the small size of these conventional methods difficult dosimetry during treatment. The objective of this work was to develop a verification methodology in vivo dosimetry in stereotactic radiotherapy with the aid of the film radiochromic Linear Accelerator with multi leaf collimators Moduleaf. The technique uses film segments radiochromic Gafchromic EBT2, with dimensions of 1x1 cm{sup 2} in area outside the coupled micro-multileaf Moduleaf Siemens. These films were inserted in the region of the central axis of the beam. The films were irradiated and calibrated to obtain the factors that determine the size dependence of the dosimetric field. With these data, we designed a computer program which calculates the density of a film must acquire when subjected to an exposure in this setting. This study evaluated five non-coplanar plans, the first with 15 fields and the other with 25 fields. Before starting the procedure, the film segment is coupled to the device, and after the treatment, the relative density is evaluated and compared with the calculated. The average value of the verification at the time of radiation dosimetry compared with the calculated by the sheet was 1.5%. The data collected in this study showed a satisfactory agreement between measured and calculated by the program in the densitometer. Thus, a methodology was developed to verify in vivo dosimetry in radiotherapy and stereotactic linear accelerator collimators Moduleaf. (author)

  19. Oral complications of radiotherapy in the head and neck; Complicacoes bucais da radioterapia em cabeca e pescoco

    Energy Technology Data Exchange (ETDEWEB)

    Jham, Bruno Correi; Freire, Addah Regina da Silva [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Faculdade de Odontologia

    2006-09-15

    Radiotherapy is a treatment modality largely used for head and neck malignancies. However, high doses of radiation in large areas, including the oral cavity, maxilla, mandible and salivary glands may result in several undesired reactions. Mucositis, candidosis, disgeusia, radiation caries, osteoradionecrosis, soft tissue necrosis and xerostomia are some of radiotherapy's complications.Aim: The aim of this study is to briefly review the side effects that may be seen in the oral cavity during or after radiotherapy treatment in the head and neck region.Basic Method Used: Review of relevant literature.Study Design: Literature review.Results: Radiotherapy is still associated with several side effects, significantly affecting patients quality of life.Conclusions: A multidisciplinary treatment, including physicians, dentists, speech therapists, nutritionists, and psychologists, is the best alternative to minimize, or even prevent such reactions. (author)

  20. Necrose pelvi-perineal pós-radioterapia para câncer de próstata: relato de caso Perineal necrosis following radiotherapy for prostate cancer: case report

    Directory of Open Access Journals (Sweden)

    Paulo Gustavo Kotze

    2007-12-01

    Full Text Available Cerca de 75 % dos pacientes irradiados para o tratamento do câncer de próstata desenvolverão sintomas proctológicos, como urgência, dor retal, tenesmo e sangramento. O objetivo deste relato é descrever a ocorrência de necrose pelvi-perineal difusa associada à radioterapia para câncer de próstata, já que casos semelhantes não foram encontrados na literatura. Descreve-se o caso de um paciente de 77 anos, com adenocarcinoma de próstata, que realizou radioterapia pélvica de 70 Gy como tratamento. Após 4 meses, identificou-se extensa lesão ulcerada de parede anterior do reto, extendendo-se superiormente até a junção retossigmoideana, com diagnóstico de proctite actínica, sem identificação de malignidade. O paciente desenvolveu necrose da pele perineal, próstata, reto e musculatura do assoalho pélvico, que foi tratada com colostomia e extenso debridamento. Apresentou boa evolução pós-operatória e realizou tratamento com oxigenoterapia hiperbárica para cicatrização da ferida. A prevenção parece ser a melhor forma de tratamento de lesões actínicas em órgãos pélvicos. Pacientes submetidos a altas doses de irradiação encontram-se em risco real de desenvolvimento de lesões mais graves.Around 75% of the patients submitted to radiotherapy for prostate cancer will develop anorectal symptoms, such as fecal urgency, bleeding, rectal pain and tenesmus. Perineal necrosis is a very rare event in these cases. The purpose of this report is the description of a diffuse perineal necrosis due to radiotherapy for the treatment of prostate cancer. This is a report of a 77-year old male, submitted to radiotherapy with 70 Gy of pelvic radiation for prostate cancer treatment. He came to outpatient practice after 4 months with anorectal complaints. Further investigation revealed severe radiation proctitis, with a perineal wound and external anal sphincter damage. The patient was submitted to a loop transverse colostomy with extended

  1. Induced quantum conformal gravity

    International Nuclear Information System (INIS)

    Novozhilov, Y.V.; Vassilevich, D.V.

    1988-11-01

    Quantum gravity is considered as induced by matter degrees of freedom and related to the symmetry breakdown in the low energy region of a non-Abelian gauge theory of fundamental fields. An effective action for quantum conformal gravity is derived where both the gravitational constant and conformal kinetic term are positive. Relation with induced classical gravity is established. (author). 15 refs

  2. Thickenings and conformal gravity

    Science.gov (United States)

    Lebrun, Claude

    1991-07-01

    A twistor correspondence is given for complex conformal space-times with vanishing Bach and Eastwood-Dighton tensors; when the Weyl curvature is algebraically general, these equations are precisely the conformal version of Einstein's vacuum equations with cosmological constant. This gives a fully curved version of the linearized correspondence of Baston and Mason [B-M].

  3. Thickenings and conformal gravity

    Energy Technology Data Exchange (ETDEWEB)

    LeBrun, C. (State Univ. of New York, Stony Brook, NY (USA). Dept. of Mathematics)

    1991-07-01

    A twistor correspondence is given for complex conformal space-times with vanishing Bach and Eastwood-Dighton tensors; when the Weyl curvature is algebraically general, these equations are precisely the conformal version of Einstein's vacuum equations with cosmological constant. This gives a fully curved version of the linearized correspondence of Baston and Mason (B-M). (orig.).

  4. Thickenings and conformal gravity

    International Nuclear Information System (INIS)

    LeBrun, C.

    1991-01-01

    A twistor correspondence is given for complex conformal space-times with vanishing Bach and Eastwood-Dighton tensors; when the Weyl curvature is algebraically general, these equations are precisely the conformal version of Einstein's vacuum equations with cosmological constant. This gives a fully curved version of the linearized correspondence of Baston and Mason [B-M]. (orig.)

  5. Conformal transformations in superspace

    International Nuclear Information System (INIS)

    Dao Vong Duc

    1977-01-01

    The spinor extension of the conformal algebra is investigated. The transformation law of superfields under the conformal coordinate inversion R defined in the superspace is derived. Using R-technique, the superconformally covariant two-point and three-point correlation functions are found

  6. Conformational stability of calreticulin

    DEFF Research Database (Denmark)

    Jørgensen, C.S.; Trandum, C.; Larsen, N.

    2005-01-01

    The conformational stability of calreticulin was investigated. Apparent unfolding temperatures (T-m) increased from 31 degrees C at pH 5 to 51 degrees C at pH 9, but electrophoretic analysis revealed that calreticulin oligomerized instead of unfolding. Structural analyses showed that the single C......-terminal a-helix was of major importance to the conformational stability of calreticulin....

  7. Conformity index: A review

    International Nuclear Information System (INIS)

    Feuvret, Loic; Noel, Georges; Mazeron, Jean-Jacques; Bey, Pierre

    2006-01-01

    We present a critical analysis of the conformity indices described in the literature and an evaluation of their field of application. Three-dimensional conformal radiotherapy, with or without intensity modulation, is based on medical imaging techniques, three-dimensional dosimetry software, compression accessories, and verification procedures. It consists of delineating target volumes and critical healthy tissues to select the best combination of beams. This approach allows better adaptation of the isodose to the tumor volume, while limiting irradiation of healthy tissues. Tools must be developed to evaluate the quality of proposed treatment plans. Dosimetry software provides the dose distribution in each CT section and dose-volume histograms without really indicating the degree of conformity. The conformity index is a complementary tool that attributes a score to a treatment plan or that can compare several treatment plans for the same patient. The future of conformal index in everyday practice therefore remains unclear

  8. Conformal invariance in supergravity

    International Nuclear Information System (INIS)

    Bergshoeff, E.A.

    1983-01-01

    In this thesis the author explains the role of conformal invariance in supergravity. He presents the complete structure of extended conformal supergravity for N <= 4. The outline of this work is as follows. In chapter 2 he briefly summarizes the essential properties of supersymmetry and supergravity and indicates the use of conformal invariance in supergravity. The idea that the introduction of additional symmetry transformations can make clear the structure of a field theory is not reserved to supergravity only. By means of some simple examples it is shown in chapter 3 how one can always introduce additional gauge transformations in a theory of massive vector fields. Moreover it is shown how the gauge invariant formulation sometimes explains the quantum mechanical properties of the theory. In chapter 4 the author defines the conformal transformations and summarizes their main properties. He explains how these conformal transformations can be used to analyse the structure of gravity. The supersymmetric extension of these results is discussed in chapter 5. Here he describes as an example how N=1 supergravity can be reformulated in a conformally-invariant way. He also shows that beyond N=1 the gauge fields of the superconformal symmetries do not constitute an off-shell field representation of extended conformal supergravity. Therefore, in chapter 6, a systematic method to construct the off-shell formulation of all extended conformal supergravity theories with N <= 4 is developed. As an example he uses this method to construct N=1 conformal supergravity. Finally, in chapter 7 N=4 conformal supergravity is discussed. (Auth.)

  9. Conformal expansions and renormalons

    Energy Technology Data Exchange (ETDEWEB)

    Rathsman, J.

    2000-02-07

    The coefficients in perturbative expansions in gauge theories are factorially increasing, predominantly due to renormalons. This type of factorial increase is not expected in conformal theories. In QCD conformal relations between observables can be defined in the presence of a perturbative infrared fixed-point. Using the Banks-Zaks expansion the authors study the effect of the large-order behavior of the perturbative series on the conformal coefficients. The authors find that in general these coefficients become factorially increasing. However, when the factorial behavior genuinely originates in a renormalon integral, as implied by a postulated skeleton expansion, it does not affect the conformal coefficients. As a consequence, the conformal coefficients will indeed be free of renormalon divergence, in accordance with previous observations concerning the smallness of these coefficients for specific observables. The authors further show that the correspondence of the BLM method with the skeleton expansion implies a unique scale-setting procedure. The BLM coefficients can be interpreted as the conformal coefficients in the series relating the fixed-point value of the observable with that of the skeleton effective charge. Through the skeleton expansion the relevance of renormalon-free conformal coefficients extends to real-world QCD.

  10. Conformal sequestering simplified

    International Nuclear Information System (INIS)

    Schmaltz, Martin; Sundrum, Raman

    2006-01-01

    Sequestering is important for obtaining flavor-universal soft masses in models where supersymmetry breaking is mediated at high scales. We construct a simple and robust class of hidden sector models which sequester themselves from the visible sector due to strong and conformally invariant hidden dynamics. Masses for hidden matter eventually break the conformal symmetry and lead to supersymmetry breaking by the mechanism recently discovered by Intriligator, Seiberg and Shih. We give a unified treatment of subtleties due to global symmetries of the CFT. There is enough review for the paper to constitute a self-contained account of conformal sequestering

  11. Conformally connected universes

    International Nuclear Information System (INIS)

    Cantor, M.; Piran, T.

    1983-01-01

    A well-known difficulty associated with the conformal method for the solution of the general relativistic Hamiltonian constraint is the appearance of an aphysical ''bag of gold'' singularity at the nodal surface of the conformal factor. This happens whenever the background Ricci scalar is too large. Using a simple model, it is demonstrated that some of these singular solutions do have a physical meaning, and that these can be considered as initial data for Universe containing black holes, which are connected, in a conformally nonsingular way with each other. The relation between the ADM mass and the horizon area in this solution supports the cosmic censorship conjecture. (author)

  12. Conformable variational iteration method

    Directory of Open Access Journals (Sweden)

    Omer Acan

    2017-02-01

    Full Text Available In this study, we introduce the conformable variational iteration method based on new defined fractional derivative called conformable fractional derivative. This new method is applied two fractional order ordinary differential equations. To see how the solutions of this method, linear homogeneous and non-linear non-homogeneous fractional ordinary differential equations are selected. Obtained results are compared the exact solutions and their graphics are plotted to demonstrate efficiency and accuracy of the method.

  13. Delineating the conformal window

    DEFF Research Database (Denmark)

    Frandsen, Mads Toudal; Pickup, Thomas; Teper, Michael

    2011-01-01

    We identify and characterise the conformal window in gauge theories relevant for beyond the standard model building, e.g. Technicolour, using the criteria of metric confinement and causal analytic couplings, which are known to be consistent with the phase diagram of supersymmetric QCD from Seiberg...... duality. Using these criteria we find perturbation theory to be consistent throughout the predicted conformal window for several of these gauge theories and we discuss recent lattice results in the light of our findings....

  14. The hypersurfaces with conformal normal Gauss map in Hn+1 and S1n+1

    Directory of Open Access Journals (Sweden)

    Shuguo Shi

    2008-03-01

    Full Text Available In this paper, we introduce the fourth fundamental forms for hypersurfaces in Hn+1 and space-like hypersurfaces in S1n+1, and discuss the conformality of the normal Gauss map of the hypersurfaces in Hn+1 and S1n+1. Particularly, we discuss the surfaces with conformal normal Gauss map in H³ and S³1, and prove a duality property. We give a Weierstrass representation formula for space-like surfaces in S³1 with conformal normal Gauss map. We also state the similar results for time-like surfaces in S³1. Some examples of surfaces in S³1 with conformal normal Gauss map are given and a fully nonlinear equation of Monge-Ampère type for the graphs in S³1 with conformal normal Gauss map is derived.Neste artigo, introduzimos a quarta forma fundamental de uma hipersuperfície em Hn+1 de uma hipersuperfície tipo-espaço em S1n+1, e discutimos a conformalidade da aplicação normal de Gauss de tais hipersuperfícies. Em particular, investigamos o caso de superfícies com aplicação normal de Gauss conforme em H³ e S³1, e provamos um teorema de dualidade. Apresentamos uma representação de Weierstrass para superfícies tipo-espaço em S³1 com aplicação de Gauss conforme. Enunciamos também resultados semelhantes para superfícies tipo-tempo em S³1. São dados alguns exemplos de superfícies em S³1 com aplicações de Gauss conformes, e é deduzida uma equação totalmente não-linear do tipo Monge-Ampère para gráficos em S³1 com aplicações de Gauss conformes.

  15. Dermatoses em renais cronicos em terapia dialitica

    Directory of Open Access Journals (Sweden)

    Luis Alberto Batista Peres

    2014-03-01

    Full Text Available Objetivo: As desordens cutâneas e das mucosas são comuns em pacientes em hemodiálise a longo prazo. A diálise prolonga a expectativa de vida, dando tempo para a manifestação destas anormalidades. Os objetivos deste estudo foram avaliar a prevalência de problemas dermatológicos em pacientes com doença renal crônica (DRC em hemodiálise. Métodos: Cento e quarenta e cinco pacientes com doença renal crônica em hemodiálise foram estudados. Todos os pacientes foram completamente analisados para as alterações cutâneas, de cabelos, mucosas e unhas por um único examinador e foram coletados dados de exames laboratoriais. Os dados foram armazenados em um banco de dados do Microsolft Excel e analisados por estatística descritiva. As variáveis contínuas foram comparadas pelo teste t de Student e as variáveis categóricas utilizando o teste do qui-quadrado ou o teste Exato de Fischer, conforme adequado. Resultados: O estudo incluiu 145 pacientes, com idade média de 53,6 ± 14,7 anos, predominantemente do sexo masculino (64,1% e caucasianos (90,0%. O tempo médio de diálise foi de 43,3 ± 42,3 meses. As principais doenças subjacentes foram: hipertensão arterial em 33,8%, diabetes mellitus em 29,6% e glomerulonefrite crônica em 13,1%. As principais manifestações dermatológicas observadas foram: xerose em 109 (75,2%, equimose em 87 (60,0%, prurido em 78 (53,8% e lentigo em 33 (22,8% pacientes. Conclusão: O nosso estudo mostrou a presença de mais do que uma dermatose por paciente. As alterações cutâneas são frequentes em pacientes em diálise. Mais estudos são necessários para melhor caracterização e manejo destas dermatoses.

  16. Conformity and statistical tolerancing

    Science.gov (United States)

    Leblond, Laurent; Pillet, Maurice

    2018-02-01

    Statistical tolerancing was first proposed by Shewhart (Economic Control of Quality of Manufactured Product, (1931) reprinted 1980 by ASQC), in spite of this long history, its use remains moderate. One of the probable reasons for this low utilization is undoubtedly the difficulty for designers to anticipate the risks of this approach. The arithmetic tolerance (worst case) allows a simple interpretation: conformity is defined by the presence of the characteristic in an interval. Statistical tolerancing is more complex in its definition. An interval is not sufficient to define the conformance. To justify the statistical tolerancing formula used by designers, a tolerance interval should be interpreted as the interval where most of the parts produced should probably be located. This tolerance is justified by considering a conformity criterion of the parts guaranteeing low offsets on the latter characteristics. Unlike traditional arithmetic tolerancing, statistical tolerancing requires a sustained exchange of information between design and manufacture to be used safely. This paper proposes a formal definition of the conformity, which we apply successively to the quadratic and arithmetic tolerancing. We introduce a concept of concavity, which helps us to demonstrate the link between tolerancing approach and conformity. We use this concept to demonstrate the various acceptable propositions of statistical tolerancing (in the space decentring, dispersion).

  17. Axiomatic conformal field theory

    International Nuclear Information System (INIS)

    Gaberdiel, M.R.; Goddard, P.

    2000-01-01

    A new rigourous approach to conformal field theory is presented. The basic objects are families of complex-valued amplitudes, which define a meromorphic conformal field theory (or chiral algebra) and which lead naturally to the definition of topological vector spaces, between which vertex operators act as continuous operators. In fact, in order to develop the theory, Moebius invariance rather than full conformal invariance is required but it is shown that every Moebius theory can be extended to a conformal theory by the construction of a Virasoro field. In this approach, a representation of a conformal field theory is naturally defined in terms of a family of amplitudes with appropriate analytic properties. It is shown that these amplitudes can also be derived from a suitable collection of states in the meromorphic theory. Zhu's algebra then appears naturally as the algebra of conditions which states defining highest weight representations must satisfy. The relationship of the representations of Zhu's algebra to the classification of highest weight representations is explained. (orig.)

  18. Extended conformal algebras

    International Nuclear Information System (INIS)

    Goddard, Peter

    1990-01-01

    The algebra of the group of conformal transformations in two dimensions consists of two commuting copies of the Virasoro algebra. In many mathematical and physical contexts, the representations of ν which are relevant satisfy two conditions: they are unitary and they have the ''positive energy'' property that L o is bounded below. In an irreducible unitary representation the central element c takes a fixed real value. In physical contexts, the value of c is a characteristic of a theory. If c < 1, it turns out that the conformal algebra is sufficient to ''solve'' the theory, in the sense of relating the calculation of the infinite set of physically interesting quantities to a finite subset which can be handled in principle. For c ≥ 1, this is no longer the case for the algebra alone and one needs some sort of extended conformal algebra, such as the superconformal algebra. It is these algebras that this paper aims at addressing. (author)

  19. Algebraic conformal field theory

    International Nuclear Information System (INIS)

    Fuchs, J.; Nationaal Inst. voor Kernfysica en Hoge-Energiefysica

    1991-11-01

    Many conformal field theory features are special versions of structures which are present in arbitrary 2-dimensional quantum field theories. So it makes sense to describe 2-dimensional conformal field theories in context of algebraic theory of superselection sectors. While most of the results of the algebraic theory are rather abstract, conformal field theories offer the possibility to work out many formulae explicitly. In particular, one can construct the full algebra A-bar of global observables and the endomorphisms of A-bar which represent the superselection sectors. Some explicit results are presented for the level 1 so(N) WZW theories; the algebra A-bar is found to be the enveloping algebra of a Lie algebra L-bar which is an extension of the chiral symmetry algebra of the WZW theory. (author). 21 refs., 6 figs

  20. Periodontal aspects of patients subjected to the radiotherapy in region of head and neck; Aspectos periodontales de pacientes sometidos a la radioterapia en region de cabeza y cuello

    Energy Technology Data Exchange (ETDEWEB)

    Nogueira Moreira, Allyson; Bueno, Audrey C [Buenos Aires Univ. (Argentina). Facultad de Odontologia; Silami de Magalhaes, Claudia; Silva Freire, Addah R. da [Universidade Estadual de Campinas, SP (Brazil)

    2007-03-15

    Mouth cancer is the sixth most frequent type in the world's population, affecting mostly developing countries. The treatment of choice for this neoplasm is the surgery associated with radiotherapy and / or chemotherapy, which often cause mouth adverse effects. The periodontal reaction to the suffering irradiation morphological and histological alterations decreased the ability of repairing and increased vulnerability to infections. The mouth conditions of the patients who will undergo cancer therapy should be assessed prior to initiation of treatment, mainly to prevent complications. This study aimed to do a literature review on the development of periodontal disease in patients undergoing radiotherapy in head and neck region. [Spanish] El cancer de boca es el sexto tipo mas frecuente en la poblacion mundial, afectando principalmente paises en desarrollo. El tratamiento de eleccion para esta neoplasia es la cirugia asociada a la radioterapia, y/o quimioterapia que muchas veces causan efectos bucales adversos. El periodoncio reacciona a la irradiacion sufriendo alteraciones morfologicas e histologicas, disminucion de la capacidad de reparo y mayor vulnerabilidad a infecciones. Las condiciones bucales de los pacientes que seran sometidas a la terapia oncologica deben ser evaluadas antes del inicio del tratamiento, principalmente para prevenir las complicaciones del mismo. Este estudio tuvo como objetivo hacer una revision de literatura sobre el desarrollo de la enfermedad periodontal en individuos sometidos a la radioterapia en region de cabeza y cuello. (autor)

  1. Killing tensors and conformal Killing tensors from conformal Killing vectors

    International Nuclear Information System (INIS)

    Rani, Raffaele; Edgar, S Brian; Barnes, Alan

    2003-01-01

    Koutras has proposed some methods to construct reducible proper conformal Killing tensors and Killing tensors (which are, in general, irreducible) when a pair of orthogonal conformal Killing vectors exist in a given space. We give the completely general result demonstrating that this severe restriction of orthogonality is unnecessary. In addition, we correct and extend some results concerning Killing tensors constructed from a single conformal Killing vector. A number of examples demonstrate that it is possible to construct a much larger class of reducible proper conformal Killing tensors and Killing tensors than permitted by the Koutras algorithms. In particular, by showing that all conformal Killing tensors are reducible in conformally flat spaces, we have a method of constructing all conformal Killing tensors, and hence all the Killing tensors (which will in general be irreducible) of conformally flat spaces using their conformal Killing vectors

  2. Postoperative radiotherapy-induced morbidity in rectal cancer Morbilidad de la radioterapia postoperatoria en el cáncer de recto

    Directory of Open Access Journals (Sweden)

    M. Garay Burdeos

    2004-11-01

    Full Text Available Objectives: we analyzed long-term morbidity and bowel function alteration after postoperative radiotherapy for rectal cancer following resection with anastomosis. Patients and methods: thirty-seven patients who underwent surgery with intention to cure and a minimal follow-up period of 3 years were included. These patients were divided into two groups: in the first group, 14 patients received postoperative chemo-radiotherapy, 5-fluorouracil plus folinic acid, and 45 Gy plus 5 Gy boost. In the second group, there were 23 patients regarded as controls. We designed a questionnaire about their bowel function and analyzed the morbidity detected in their follow-up. Results: the group that was treated with postoperative chemo-radiotherapy had more daily bowel movements (p = 0.03 and night-time movements (p = 0.04; incontinence (69.2 versus 17.4% in the control group; p = 0.002, and perianal skin irritation (p = 0.04 versus the control group. Although without meaningful differences, the group under treatment wore a pad more often, had more defecatory urgency, could distinguish worse gas from stool, and needed more frequently antidiarrheal measures. Major complications were present in 28.6% of the under-treatment group: three intestinal resections were performed due to actinic stenosis; one patient had a residual stercoral fistula; another had several occlusive crises solved with medical treatment. Conclusions: postoperative chemo-radiotherapy had a high morbidity rate, which determined a significant alteration in quality of life. Accuracy in indication is therefore necessary, as well as a consideration of other alternatives for treatment, such as preoperative chemo-radiotherapy and total mesorectal excision.Objetivos: analizar la morbilidad y alteración del funcionalismo rectal a largo plazo de la radioterapia postoperatoria tras resección con anastomosis en el cáncer de recto. Material y métodos: se incluyen 37 pacientes intervenidos con intenci

  3. Study of the difference in rectal and ear canal temperature according to the conformation of the acoustic conch in dogsEstudo da diferença das temperaturas retal e do canal auditivo de acordo com a conformação da concha acústica em cães

    Directory of Open Access Journals (Sweden)

    Eduardo Negri Mueller

    2012-10-01

    Full Text Available The auditory thermometry has being used for measurement of temperature of dogs. However there is different acoustic conch conformation in this species, being that the pendulous ears can alter the auditory microclimate. This research aimed to study the difference of rectal and auditory canal temperatures according to acoustic conch conformation in dogs. One hundred and eleven dogs were used with erect ears (group I, semi-pendulous (group II and pendulous (group II with 37 animals each group. The measurement of rectal temperature (TR was realized with traditional thermometer mercury column and measurement of both external ears temperature with infrared ear thermometer. The average hearing temperature (TAM was obtained and realized difference between TR and TAM, being the results classify in scores, A=TAMA termometria auditiva vem sendo utilizada para mensuração da temperatura em cães. Porém, existem diferentes conformações da concha acústica nesta espécie, sendo que orelhas pendulares podem alterar o microclima auditivo. Portanto, objetivou-se estudar a diferença das temperaturas retal e do canal auditivo de acordo com a conformação da concha acústica em cães. Foram utilizados 111 cães hígidos com orelhas ereta (grupo I, semipendular (grupo II e pendular (grupo III com 37 animais cada. A aferição da temperatura retal (TR foi realizada com termômetro tradicional coluna de mercúrio e aferição da temperatura de ambas as orelhas externas com termômetro auricular infravermelho. Foi obtida temperatura auditiva média (TAM e realizada diferença entre TR e TAM, sendo os resultados classificados em escores, A=TAMem até 1,2ºC e B=TAMem mais de 1,2ºC. A média da TAM foi 37,15ºC±0,81, enquanto que a da TR foi 38,68ºC±0,59. A diferença média entre TAM e TR foi 1,53ºC±0,75. Setenta e uma orelhas (63,96% foram classificadas no escore B e 40 (36,04% no escore A. A média da TAM foi 37,17°C±0,85, 37,35°C±0,50 e 36

  4. Massive Conformal Gravity

    International Nuclear Information System (INIS)

    Faria, F. F.

    2014-01-01

    We construct a massive theory of gravity that is invariant under conformal transformations. The massive action of the theory depends on the metric tensor and a scalar field, which are considered the only field variables. We find the vacuum field equations of the theory and analyze its weak-field approximation and Newtonian limit.

  5. Taming the conformal zoo

    International Nuclear Information System (INIS)

    Moore, G.; Seiberg, N.

    1989-01-01

    All known rational conformal field theories may be obtained from (2+1)-dimensional Chern-Simons gauge theories by appropriate choice of gauge group. We conjecture that all rational field theories are classified by groups via (2+1)-dimensional Chern-Simons gauge theories. (orig.)

  6. Conformal special relativity

    International Nuclear Information System (INIS)

    Maia, M.D.

    2006-01-01

    It is shown that the information loss/recovery theorem based on the ADS/CFT correspondence is not consistent with the stability of the Schwarzschild or Reissner-Nordstrom black holes. Nonetheless, the conformal invariance of Yang-Mills theory points to new relativity principle compatible with quantum unitarity near those black holes

  7. Animal culture: chimpanzee conformity?

    Science.gov (United States)

    van Schaik, Carel P

    2012-05-22

    Culture-like phenomena in wild animals have received much attention, but how good is the evidence and how similar are they to human culture? New data on chimpanzees suggest their culture may even have an element of conformity. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Parafermionic conformal field theory

    International Nuclear Information System (INIS)

    Kurak, V.

    1989-09-01

    Conformal parafermionic field theories are reviewed with emphasis on the computation of their OPE estructure constants. It is presented a simple computational of these for the Z(N) parafermions, unveilling their Lie algebra content. (A.C.A.S.) [pt

  9. Quantifying polypeptide conformational space: sensitivity to conformation and ensemble definition.

    Science.gov (United States)

    Sullivan, David C; Lim, Carmay

    2006-08-24

    Quantifying the density of conformations over phase space (the conformational distribution) is needed to model important macromolecular processes such as protein folding. In this work, we quantify the conformational distribution for a simple polypeptide (N-mer polyalanine) using the cumulative distribution function (CDF), which gives the probability that two randomly selected conformations are separated by less than a "conformational" distance and whose inverse gives conformation counts as a function of conformational radius. An important finding is that the conformation counts obtained by the CDF inverse depend critically on the assignment of a conformation's distance span and the ensemble (e.g., unfolded state model): varying ensemble and conformation definition (1 --> 2 A) varies the CDF-based conformation counts for Ala(50) from 10(11) to 10(69). In particular, relatively short molecular dynamics (MD) relaxation of Ala(50)'s random-walk ensemble reduces the number of conformers from 10(55) to 10(14) (using a 1 A root-mean-square-deviation radius conformation definition) pointing to potential disconnections in comparing the results from simplified models of unfolded proteins with those from all-atom MD simulations. Explicit waters are found to roughen the landscape considerably. Under some common conformation definitions, the results herein provide (i) an upper limit to the number of accessible conformations that compose unfolded states of proteins, (ii) the optimal clustering radius/conformation radius for counting conformations for a given energy and solvent model, (iii) a means of comparing various studies, and (iv) an assessment of the applicability of random search in protein folding.

  10. Transportation Conformity Training and Presentations

    Science.gov (United States)

    EPA's OTAQ has provided multiple conformity training sessions in the past to assist state and local governments in implementing conformity requirements. As training information is prepared for other venues, it will be posted on this page.

  11. Hot Conformal Gauge Theories

    DEFF Research Database (Denmark)

    Mojaza, Matin; Pica, Claudio; Sannino, Francesco

    2010-01-01

    of flavors. Surprisingly this number, if computed to the order g^2, agrees with previous predictions for the lower boundary of the conformal window for nonsupersymmetric gauge theories. The higher order results tend to predict a higher number of critical flavors. These are universal properties, i......We compute the nonzero temperature free energy up to the order g^6 \\ln(1/g) in the coupling constant for vector like SU(N) gauge theories featuring matter transforming according to different representations of the underlying gauge group. The number of matter fields, i.e. flavors, is arranged...... in such a way that the theory develops a perturbative stable infrared fixed point at zero temperature. Due to large distance conformality we trade the coupling constant with its fixed point value and define a reduced free energy which depends only on the number of flavors, colors and matter representation. We...

  12. Conformational flexibility of aspartame.

    Science.gov (United States)

    Toniolo, Claudio; Temussi, Pierandrea

    2016-05-01

    L-Aspartyl-L-phenylalanine methyl ester, better known as aspartame, is not only one of the most used artificial sweeteners, but also a very interesting molecule with respect to the correlation between molecular structure and taste. The extreme conformational flexibility of this dipeptide posed a huge difficulty when researchers tried to use it as a lead compound to design new sweeteners. In particular, it was difficult to take advantage of its molecular model as a mold to infer the shape of the, then unknown, active site of the sweet taste receptor. Here, we follow the story of the 3D structural aspects of aspartame from early conformational studies to recent docking into homology models of the receptor. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 376-384, 2016. © 2016 Wiley Periodicals, Inc.

  13. Conformal description of spinning particles

    International Nuclear Information System (INIS)

    Todorov, I.T.

    1986-01-01

    This book is an introduction to the application of the conformal group to quantum field theory of particles with spin. After an introduction to the twistor representations of the conformal group of a conformally flat space-time and twistor flag manifolds with Su(2,2) orbits the classical phase space of conformal spinning particles is described. Thereafter the twistor description of classical zero mass fields is considered together with the quantization. (HSI)

  14. Conformal boundaries of warped products

    DEFF Research Database (Denmark)

    Kokkendorff, Simon Lyngby

    2006-01-01

    In this note we prove a result on how to determine the conformal boundary of a type of warped product of two length spaces in terms of the individual conformal boundaries. In the situation, that we treat, the warping and conformal distortion functions are functions of distance to a base point....... The result is applied to produce examples of CAT(0)-spaces, where the conformal and ideal boundaries differ in interesting ways....

  15. Conformal radiotherapy: a glossary

    International Nuclear Information System (INIS)

    Dubray, B.; Giraud, P.; Beaudre, A.

    1999-01-01

    Most of the concepts and terms related to conformal radiotherapy were produced by English-speaking authors and eventually validated by international groups of experts, whose working language was also English. Therefore, a significant part of this literature is poorly accessible to the French-speaking radiation oncology community. The present paper gathers the 'official' definitions already published in French, along with propositions for the remaining terms which should be submitted to a more formal and representative validation process. (author)

  16. Sequelas bucais da radioterapia de cabeça e pescoço Oral sequelae of head and neck radiotherapy

    Directory of Open Access Journals (Sweden)

    Daniel Antunes Freitas

    2011-12-01

    Full Text Available TEMA: cirurgia, radioterapia e quimioterapia são as modalidades terapêuticas usadas no tratamento de câncer bucal. Podem ser usadas isoladas ou conjuntamente. Radiação ionizante causa lesões nos tecidos normais localizados no campo de radiação. Isto se torna particularmente evidente nas regiões de cabeça, uma área complexa composta de várias estruturas diferentes que respondem diferentemente à radiação. As seqüelas orais resultantes podem causar problemas substanciais durante e depois da terapia de radiação e são os maiores fatores de determinação na qualidade de vida dos pacientes. Dentre as complicações da radioterapia estão a xerostomia, osteorradionecrose, mucosite e candidose. OBJETIVO: apresentar aos profissionais de saúde uma reflexão sobre as questões pertinentes às sequelas bucais da radioterapia de cabeça e pescoço. CONCLUSÃO: o acompanhamento odontológico sistemático pode minimizar os efeitos da radiação sobre os tecidos da cavidade bucal.BACKGROUND: surgery, radiotherapy and chemotherapy are therapeutic modalities used in the treatment of oral cancer. They can be used separately or in combination. Ionizing irradiation causes damage to normal tissues located at the radiation field. This becomes particularly evident in the head and neck region, a complex area composed of several dissimilar structures that respond differently to radiation. The resulting oral sequelae may cause substantial problems during and after radiation therapy and are major factors in determining the patient's quality of life. Xerostomia, osteoradionecrosis, mucositis and candidosis are some of radiotherapy's complications. PURPOSE: introduce health professionals to reflect on issues relevant to oral sequelae of head and neck radiotherapy. CONCLUSION: regular dental follow-up may reduce the effects of radiation in the tissues of the oral cavity.

  17. Rectum neoplasms treatment advanced with radio and chemotherapy before - surgery; Tratamiento de cancer de recto localmente avanzado con radioterapia y quimioterapia preoperatoria

    Energy Technology Data Exchange (ETDEWEB)

    Luongo Cespedes, A; Aguiar Vitacca, S [and others

    1993-12-01

    In Uruguay the colorectal neoplasms has a can rate of mobility. The surgery has 13-26% local recurrence. The irradiation before surgery has demonstrated to improve the resect and the local control.The objective of this protocol it is to decrease the percentage of local relapse , using radiotherapy(RT) before surgery and concomitant chemotherapy that potencies the effect of the RT, improvement this way the therapeutic quotient (AU) [Spanish] En Uruguay el cancer colorrectal tiene una lata tasa de mortalidad.La cirugia exclusiva,tiene 13-26 % de recurrencias locales.La irradiacion preoperatoria ha demostrado mejorar la resecabilidad y el control local.El objetivo de este protocolo es disminuir el porcentaje de recidiva local,utilizando radioterapia(RT) preoperatoria y quimioterapia concomitante que potencie el efecto de la RT,mejorando asi el cociente terapeutico (AU)

  18. Angiofibroma juvenil de nasofaringe:: actualización de los resultados de la radioterapia Nasopharyngeal juvenile angiofribroma:: updating of radiotherapy results

    Directory of Open Access Journals (Sweden)

    José Alert Silva

    2010-03-01

    Full Text Available INTRODUCCIÓN. El angiofibroma juvenil de nasofaringe es un tumor benigno infrecuente, compuesto de tejido conectivo fibroso y abundancia de espacios vasculares revestidos de endotelio. Es casi exclusivo del sexo masculino y de la adolescencia. El tratamiento de elección es la exéresis, sin descartar otras posibilidades como la radioterapia. El objetivo del presente estudio fue presentar los resultados de esta última como opción terapéutica. MÉTODOS. Se estudió una serie de 11 pacientes, todos del sexo masculino, con edades entre 9 y 16 años, que fueron tratados en el Instituto Nacional de Oncología y Radiobiología de La Habana entre 1990 y 2005. Los pacientes fueron seguidos entre 48 y 306 meses. La radioterapia aplicada consistió en la irradiación de todo el volumen tumoral, con un margen de seguridad, en dosis de 40 a 60 Gy, con 1,8 Gy por sesión. Asociado a la radioterapia se utilizó interferón, durante y después de la irradiación, y poliquimioterapia en 1 paciente. RESULTADOS. Se obtuvo la remisión completa mantenida, sin recidivas, en 10 pacientes. No hubo pacientes con un segundo tumor. Presentaron complicaciones tempranas todos los pacientes, y tardías, solo algunos. Entre las complicaciones tempranas se halló radiomucositis y conjuntivis radiógena, y las más graves de las tardías fueron la pérdida permanente de las pestañas del párpado inferior en un caso y cataratas radiógenas en 4 pacientes. CONCLUSIONES. La radioterapia es un tratamiento que conserva su utilidad e indicaciones específicas.INTRODUCTION: The nasopharyngeal juvenile angiofribroma is a uncommon benign tumor composed of fibrous connective tissue and many vascular spaces covered by endothelium. It is almost exclusive of male sex and of adolescents. Choice treatment is the exeresis without obviate other possibilities as the radiotherapy. The aim of present study was to show the results of this latter as therapeutical option. METHODS: Authors

  19. Conformational analysis by intersection: CONAN.

    Science.gov (United States)

    Smellie, Andrew; Stanton, Robert; Henne, Randy; Teig, Steve

    2003-01-15

    As high throughput techniques in chemical synthesis and screening improve, more demands are placed on computer assisted design and virtual screening. Many of these computational methods require one or more three-dimensional conformations for molecules, creating a demand for a conformational analysis tool that can rapidly and robustly cover the low-energy conformational spaces of small molecules. A new algorithm of intersection is presented here, which quickly generates (on average heuristics are applied after intersection to generate a small representative collection of conformations that span the conformational space. In a study of approximately 97,000 randomly selected molecules from the MDDR, results are presented that explore these conformations and their ability to cover low-energy conformational space. Copyright 2002 Wiley Periodicals, Inc. J Comput Chem 24: 10-20, 2003

  20. Conformal superalgebras via tractor calculus

    Science.gov (United States)

    Lischewski, Andree

    2015-01-01

    We use the manifestly conformally invariant description of a Lorentzian conformal structure in terms of a parabolic Cartan geometry in order to introduce a superalgebra structure on the space of twistor spinors and normal conformal vector fields formulated in purely algebraic terms on parallel sections in tractor bundles. Via a fixed metric in the conformal class, one reproduces a conformal superalgebra structure that has been considered in the literature before. The tractor approach, however, makes clear that the failure of this object to be a Lie superalgebra in certain cases is due to purely algebraic identities on the spinor module and to special properties of the conformal holonomy representation. Moreover, it naturally generalizes to higher signatures. This yields new formulas for constructing new twistor spinors and higher order normal conformal Killing forms out of existing ones, generalizing the well-known spinorial Lie derivative. Moreover, we derive restrictions on the possible dimension of the space of twistor spinors in any metric signature.

  1. Alteraciones estructurales de la glándula tiroidea tras la radioterapia Structural alterations of thyroid gland after radiotherapy

    Directory of Open Access Journals (Sweden)

    Caridad Verdecia Cañizares

    2009-03-01

    Full Text Available INTRODUCCIÓN. El objetivo de la presente publicación fue comunicar los casos detectados en nuestro estudio de anomalías estructurales de la glándula tiroidea en pacientes que recibieron radioterapia para el tratamiento de tumores malignos de cabeza y cuello. MÉTODOS. Se realizó un estudio descriptivo de corte transversal para determinar la prevalencia de alteraciones estructurales de la glándula tiroides en 43 pacientes sobrevivientes de tumores malignos de cabeza y cuello, que habían recibido radioterapia y que fueron atendidos en los Hospitales Pediátricos Docentes «William Soler» y «Juan Manuel Márquez» en un período de 10 años (1990 a 2000. RESULTADOS. La alteración estructural de la glándula tiroides más frecuente fue la fibrosis glandular (18,5 %, seguida del adenoma tiroideo y de quistes simples de la glándula (11,1 % respectivamente. Hubo 2 casos de carcinoma diferenciado de la glándula tiroides (7,4 % y uno de lesión mixta adenofolicular (3,7 %. La citología aspirativa con aguja fina permitió la detección de la mayoría de estas lesiones y posibilitó, guiada por ecografía, la detección de lesiones intraparenquimatosas de la glándula. El tratamiento de las alteraciones encontradas fue quirúrgico y se practicó tiroidectomía total a los dos pacientes con carcinoma diferenciado de la glándula tiroides, tiroidectomía subtotal a los tres pacientes con quistes de la glándula y adenomas tiroideos. En los casos de fibrosis glandular se detectó hipofunción tiroidea concomitante, por tanto se administró tratamiento sustitutivo con levotiroxina. CONCLUSIONES. La citología aspirativa con aguja fina guiada mediante ecografía de la glándula tiroides permitió diagnosticar alteraciones estructurales no detectadas en el examen físico. La patología maligna más irradiada correspondió a los linfomas no Hodgkin. Cuanto mayor es la dosis de irradiación, mayor es la patología tiroidea.INTRODUCTION: The aim of

  2. Classical extended conformal symmetries

    International Nuclear Information System (INIS)

    Viswanathan, R.

    1990-02-01

    Extensions of the Virasoro algebra are constructed as Poisson brackets of higher spin fields which appear as coefficient fields in certain covariant derivative operators of order N. These differential operators are constructed so as to be covariant under reparametrizations on fields of definite conformal dimension. Factorization of such an N-th order operator in terms of first order operators, together with the inclusion of a spin one U(1) current, is shown to lead to a two-parameter W-algebra. One of these parameters plays the role of interpolating between W-algebras based on different Lie algebras of the same rank. (author). 11 refs

  3. Conformally symmetric traversable wormholes

    International Nuclear Information System (INIS)

    Boehmer, Christian G.; Harko, Tiberiu; Lobo, Francisco S. N.

    2007-01-01

    Exact solutions of traversable wormholes are found under the assumption of spherical symmetry and the existence of a nonstatic conformal symmetry, which presents a more systematic approach in searching for exact wormhole solutions. In this work, a wide variety of solutions are deduced by considering choices for the form function, a specific linear equation of state relating the energy density and the pressure anisotropy, and various phantom wormhole geometries are explored. A large class of solutions impose that the spatial distribution of the exotic matter is restricted to the throat neighborhood, with a cutoff of the stress-energy tensor at a finite junction interface, although asymptotically flat exact solutions are also found. Using the 'volume integral quantifier', it is found that the conformally symmetric phantom wormhole geometries may, in principle, be constructed by infinitesimally small amounts of averaged null energy condition violating matter. Considering the tidal acceleration traversability conditions for the phantom wormhole geometry, specific wormhole dimensions and the traversal velocity are also deduced

  4. Supergravitational conformal Galileons

    Science.gov (United States)

    Deen, Rehan; Ovrut, Burt

    2017-08-01

    The worldvolume actions of 3+1 dimensional bosonic branes embedded in a five-dimensional bulk space can lead to important effective field theories, such as the DBI conformal Galileons, and may, when the Null Energy Condition is violated, play an essential role in cosmological theories of the early universe. These include Galileon Genesis and "bouncing" cosmology, where a pre-Big Bang contracting phase bounces smoothly to the presently observed expanding universe. Perhaps the most natural arena for such branes to arise is within the context of superstring and M -theory vacua. Here, not only are branes required for the consistency of the theory, but, in many cases, the exact spectrum of particle physics occurs at low energy. However, such theories have the additional constraint that they must be N = 1 supersymmetric. This motivates us to compute the worldvolume actions of N = 1 supersymmetric three-branes, first in flat superspace and then to generalize them to N = 1 supergravitation. In this paper, for simplicity, we begin the process, not within the context of a superstring vacuum but, rather, for the conformal Galileons arising on a co-dimension one brane embedded in a maximally symmetric AdS 5 bulk space. We proceed to N = 1 supersymmetrize the associated worldvolume theory and then generalize the results to N = 1 supergravity, opening the door to possible new cosmological scenarios

  5. Ward identities for conformal models

    International Nuclear Information System (INIS)

    Lazzarini, S.; Stora, R.

    1988-01-01

    Ward identities which express the symmetry of conformal models are treated. Diffeomorphism invariance or locally holomorphic coordinate transformations are used. Diffeomorphism invariance is then understood in terms of Riemannian geometry. Two different sets of Ward identities expressing diffeomorphism invariance in a conformally invariant way are found for the free bosonic string. Using a geometrical argument, the correct invariance for a large class of conformal models is given

  6. Conformational analysis of lignin models

    International Nuclear Information System (INIS)

    Santos, Helio F. dos

    2001-01-01

    The conformational equilibrium for two 5,5' biphenyl lignin models have been analyzed using a quantum mechanical semiempirical method. The gas phase and solution structures are discussed based on the NMR and X-ray experimental data. The results obtained showed that the observed conformations are solvent-dependent, being the geometries and the thermodynamic properties correlated with the experimental information. This study shows how a systematic theoretical conformational analysis can help to understand chemical processes at a molecular level. (author)

  7. On the linear conformal gravitation

    International Nuclear Information System (INIS)

    Pal'chik, M.Ya.; Fradkin, E.S.

    1984-01-01

    Conformal gravitation is analyzed under the assumption that its solution possesses the property of conformal symmetry. This assumption has sense in the case of small distances and only for definite types of matter fields, namely: at special choice of matter fields and their interactions, providing a lack of conformal anomalies; or at definite magnitudes of binding constants, coinciding with the zeroes of the Gell-Mann-Low function. The field equations, of the group-theoretical natura are obtained

  8. Fermion-scalar conformal blocks

    Energy Technology Data Exchange (ETDEWEB)

    Iliesiu, Luca [Joseph Henry Laboratories, Princeton University,Washington Road, Princeton, NJ 08544 (United States); Kos, Filip [Department of Physics, Yale University,217 Prospect Street, New Haven, CT 06520 (United States); Poland, David [Department of Physics, Yale University,217 Prospect Street, New Haven, CT 06520 (United States); School of Natural Sciences, Institute for Advanced Study,1 Einstein Dr, Princeton, New Jersey 08540 (United States); Pufu, Silviu S. [Joseph Henry Laboratories, Princeton University,Washington Road, Princeton, NJ 08544 (United States); Simmons-Duffin, David [School of Natural Sciences, Institute for Advanced Study,1 Einstein Dr, Princeton, New Jersey 08540 (United States); Yacoby, Ran [Joseph Henry Laboratories, Princeton University,Washington Road, Princeton, NJ 08544 (United States)

    2016-04-13

    We compute the conformal blocks associated with scalar-scalar-fermion-fermion 4-point functions in 3D CFTs. Together with the known scalar conformal blocks, our result completes the task of determining the so-called ‘seed blocks’ in three dimensions. Conformal blocks associated with 4-point functions of operators with arbitrary spins can now be determined from these seed blocks by using known differential operators.

  9. Instantons in conformal gravity

    International Nuclear Information System (INIS)

    Strominger, A.; Horowitz, G.T.; Perry, M.J.

    1984-01-01

    Fe study extrema of the general conformally invariant action: Ssub(c)=∫1/sub(α) 2 Csup(abcd)Csub(abcd)+γRsup(abcd*)Rsup(*)sub(abcd)+iTHETARsup(abcd)*Rsub(abcd). We find the first examples in four dimensions of asymptotically euclidean gravitational instantons. These have arbitrary Euler number and Hirzebruch signature. Some of these instantons represent tunneling between zero-curvature vacua that are not related by small gauge transformations. Others represent tunneling between flat space and topologically non-trivial zero-energy initial data. A general formula for the one-loop determinant is derived in terms of the renormalization group invariant masses, the volume of space-time, the Euler number and the Hirzebruch signature. (orig.)

  10. Conformance and Deviance

    DEFF Research Database (Denmark)

    Gjerdrum Pedersen, Esben Rahbek; Neergaard, Peter; Thusgaard Pedersen, Janni

    2013-01-01

    This paper analyses how large Danish companies are responding to new governmental regulation which requires them to report on corporate social responsibility (CSR). The paper is based on an analysis of 142 company annual reports required by the new Danish regulation regarding CSR reporting, plus 10...... interviews with first-time reporting companies and six interviews with companies that failed to comply with the new law. It is concluded that coercive pressures from government have an impact on CSR reporting practices. Further, the analysis finds traces of mimetic isomorphism which inspires a homogenisation...... in CSR reporting practices. Finally, it is argued that non-conformance with the new regulatory requirements is not solely about conscious resistance but may also be caused by, for example, lack of awareness, resource limitations, misinterpretations, and practical difficulties....

  11. Reflections on Conformal Spectra

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    We use modular invariance and crossing symmetry of conformal field theory to reveal approximate reflection symmetries in the spectral decompositions of the partition function in two dimensions in the limit of large central charge and of the four-point function in any dimension in the limit of large scaling dimensions Δ0 of external operators. We use these symmetries to motivate universal upper bounds on the spectrum and the operator product expansion coefficients, which we then derive by independent techniques. Some of the bounds for four-point functions are valid for finite Δ0 as well as for large Δ0. We discuss a similar symmetry in a large spacetime dimension limit. Finally, we comment on the analogue of the Cardy formula and sparse light spectrum condition for the four-point function. (based on 1510.08772 with Kim & Ooguri). This seminar will be given via videolink

  12. Conformal boundary loop models

    International Nuclear Information System (INIS)

    Jacobsen, Jesper Lykke; Saleur, Hubert

    2008-01-01

    We study a model of densely packed self-avoiding loops on the annulus, related to the Temperley-Lieb algebra with an extra idempotent boundary generator. Four different weights are given to the loops, depending on their homotopy class and whether they touch the outer rim of the annulus. When the weight of a contractible bulk loop x≡q+q -1 element of (-2,2], this model is conformally invariant for any real weight of the remaining three parameters. We classify the conformal boundary conditions and give exact expressions for the corresponding boundary scaling dimensions. The amplitudes with which the sectors with any prescribed number and types of non-contractible loops appear in the full partition function Z are computed rigorously. Based on this, we write a number of identities involving Z which hold true for any finite size. When the weight of a contractible boundary loop y takes certain discrete values, y r ≡([r+1] q )/([r] q ) with r integer, other identities involving the standard characters K r,s of the Virasoro algebra are established. The connection with Dirichlet and Neumann boundary conditions in the O(n) model is discussed in detail, and new scaling dimensions are derived. When q is a root of unity and y=y r , exact connections with the A m type RSOS model are made. These involve precise relations between the spectra of the loop and RSOS model transfer matrices, valid in finite size. Finally, the results where y=y r are related to the theory of Temperley-Lieb cabling

  13. Conformal Aspects of QCD

    Energy Technology Data Exchange (ETDEWEB)

    Brodsky, S

    2003-11-19

    Theoretical and phenomenological evidence is now accumulating that the QCD coupling becomes constant at small virtuality; i.e., {alpha}{sub s}(Q{sup 2}) develops an infrared fixed point in contradiction to the usual assumption of singular growth in the infrared. For example, the hadronic decays of the {tau} lepton can be used to determine the effective charge {alpha}{sub {tau}}(m{sub {tau}{prime}}{sup 2}) for a hypothetical {tau}-lepton with mass in the range 0 < m{sub {tau}{prime}} < m{sub {tau}}. The {tau} decay data at low mass scales indicates that the effective charge freezes at a value of s = m{sub {tau}{prime}}{sup 2} of order 1 GeV{sup 2} with a magnitude {alpha}{sub {tau}} {approx} 0.9 {+-} 0.1. The near-constant behavior of effective couplings suggests that QCD can be approximated as a conformal theory even at relatively small momentum transfer and why there are no significant running coupling corrections to quark counting rules for exclusive processes. The AdS/CFT correspondence of large N{sub c} supergravity theory in higher-dimensional anti-de Sitter space with supersymmetric QCD in 4-dimensional space-time also has interesting implications for hadron phenomenology in the conformal limit, including an all-orders demonstration of counting rules for exclusive processes and light-front wavefunctions. The utility of light-front quantization and light-front Fock wavefunctions for analyzing nonperturbative QCD and representing the dynamics of QCD bound states is also discussed.

  14. Logarithmic conformal field theory through nilpotent conformal dimensions

    International Nuclear Information System (INIS)

    Moghimi-Araghi, S.; Rouhani, S.; Saadat, M.

    2001-01-01

    We study logarithmic conformal field theories (LCFTs) through the introduction of nilpotent conformal weights. Using this device, we derive the properties of LCFTs such as the transformation laws, singular vectors and the structure of correlation functions. We discuss the emergence of an extra energy momentum tensor, which is the logarithmic partner of the energy momentum tensor

  15. Replacement between conformity and counter-conformity in consumption decisions.

    Science.gov (United States)

    Chou, Ting-Jui; Chang, En-Chung; Dai, Qi; Wong, Veronica

    2013-02-01

    This study assessed, in a Chinese context, how self-esteem interacts with perceived similarity and uniqueness to yield cognitive dissonance, and whether the dissonance leads to self-reported conformity or counter-conformity behavior. Participants were 408 respondents from 4 major Chinese cities (M age = 33.0 yr., SD = 4.3; 48% men). Self-perceptions of uniqueness, similarity, cognitive dissonance, self-esteem and need to behave in conformity or counter-conformity were measured. A theoretical model was assessed in four situations, relating the ratings of self-esteem and perceived similarity/uniqueness to the way other people at a wedding were dressed, and the resultant cognitive dissonance and conformity/ counter-conformity behavior. Regardless of high or low self-esteem, all participants reported cognitive dissonance when they were told that they were dressed extremely similarly to or extremely differently from the other people attending the wedding. However, the conforming/counter-conforming strategies used by participants to resolve the cognitive dissonance differed. When encountering dissonance induced by the perceived extreme uniqueness of dress, participants with low self-esteem tended to say they would dress next time so as to conform with the way others were dressed, while those with high self-esteem indicated they would continue their counter-conformity in attire. When encountering dissonance induced by the perceived extreme similarity to others, both those with high and low self-esteem tended to say they would dress in an unorthodox manner to surprise other people in the future.

  16. On Associative Conformal Algebras of Linear Growth

    OpenAIRE

    Retakh, Alexander

    2000-01-01

    Lie conformal algebras appear in the theory of vertex algebras. Their relation is similar to that of Lie algebras and their universal enveloping algebras. Associative conformal algebras play a role in conformal representation theory. We introduce the notions of conformal identity and unital associative conformal algebras and classify finitely generated simple unital associative conformal algebras of linear growth. These are precisely the complete algebras of conformal endomorphisms of finite ...

  17. Recent advancements in conformal gravity

    International Nuclear Information System (INIS)

    O’Brien, James G.; Chaykov, Spasen S.; Moss, Robert J.; Dentico, Jeremy; Stulge, Modestas; Stefanski, Brian

    2017-01-01

    In recent years, due to the lack of direct observed evidence of cold dark matter, coupled with the shrinking parameter space to search for new dark matter particles, there has been increased interest in Alternative Gravitational theories. This paper, addresses three recent advances in conformal gravity, a fourth order renormalizable metric theory of gravitation originally formulated by Weyl, and later advanced by Mannheim and Kazanas. The first section of the paper applies conformal gravity to the rotation curves of the LITTLE THINGS survey, extending the total number of rotation curves successfully fit by conformal gravity to well over 200 individual data sets without the need for additional dark matter. Further, in this rotation curve study, we show how MOND and conformal gravity compare for each galaxy in the sample. Second, we look at the original Zwicky problem of applying the virial theorem to the Coma cluster in order to get an estimate for the cluster mass. However, instead of using the standard Newtonian potential, here we use the weak field approximation of conformal gravity. We show that in the conformal case we can get a much smaller mass estimate and thus there is no apparent need to include dark matter. We then show that this calculation is in agreement with the observational data from other well studied clusters. Last, we explore the calculation of the deflection of starlight through conformal gravity, as a first step towards applying conformal gravity to gravitaitonal lensing. (paper)

  18. Conformal invariance in harmonic superspace

    International Nuclear Information System (INIS)

    Galperin, A.; Ivanov, E.; Ogievetsky, V.; Sokatchev, E.

    1985-01-01

    N=2 conformal supersymmetry is realized in harmonic superspace, its peculiarities are analyzed. The coordinate group and analytical prepotentials for N=2 conformal supergravity are found. A new version of the N=2 Einstein supergravity with infinite number of auxiliary fields is suggested. A hypermultiplet without central charges and constraints is used as a compensator

  19. Counselor Identity: Conformity or Distinction?

    Science.gov (United States)

    McLaughlin, Jerry E.; Boettcher, Kathryn

    2009-01-01

    The authors explore 3 debates in other disciplines similar to counseling's identity debate in order to learn about common themes and outcomes. Conformity, distinction, and cohesion emerged as common themes. They conclude that counselors should retain their distinctive, humanistic approach rather than conforming to the dominant, medical approach.

  20. Recursion Relations for Conformal Blocks

    CERN Document Server

    Penedones, João; Yamazaki, Masahito

    2016-09-12

    In the context of conformal field theories in general space-time dimension, we find all the possible singularities of the conformal blocks as functions of the scaling dimension $\\Delta$ of the exchanged operator. In particular, we argue, using representation theory of parabolic Verma modules, that in odd spacetime dimension the singularities are only simple poles. We discuss how to use this information to write recursion relations that determine the conformal blocks. We first recover the recursion relation introduced in 1307.6856 for conformal blocks of external scalar operators. We then generalize this recursion relation for the conformal blocks associated to the four point function of three scalar and one vector operator. Finally we specialize to the case in which the vector operator is a conserved current.

  1. Conformal algebra of Riemann surfaces

    International Nuclear Information System (INIS)

    Vafa, C.

    1988-01-01

    It has become clear over the last few years that 2-dimensional conformal field theories are a crucial ingredient of string theory. Conformal field theories correspond to vacuum solutions of strings; or more precisely we know how to compute string spectrum and scattering amplitudes by starting from a formal theory (with a proper value of central charge of the Virasoro algebra). Certain non-linear sigma models do give rise to conformal theories. A lot of progress has been made in the understanding of conformal theories. The author discusses a different view of conformal theories which was motivated by the development of operator formalism on Riemann surfaces. The author discusses an interesting recent work from this point of view

  2. The logarithmic conformal field theories

    International Nuclear Information System (INIS)

    Rahimi Tabar, M.R.; Aghamohammadi, A.; Khorrami, M.

    1997-01-01

    We study the correlation functions of logarithmic conformal field theories. First, assuming conformal invariance, we explicitly calculate two- and three-point functions. This calculation is done for the general case of more than one logarithmic field in a block, and more than one set of logarithmic fields. Then we show that one can regard the logarithmic field as a formal derivative of the ordinary field with respect to its conformal weight. This enables one to calculate any n-point function containing the logarithmic field in terms of ordinary n-point functions. Finally, we calculate the operator product expansion (OPE) coefficients of a logarithmic conformal field theory, and show that these can be obtained from the corresponding coefficients of ordinary conformal theory by a simple derivation. (orig.)

  3. Conformal solids and holography

    Science.gov (United States)

    Esposito, A.; Garcia-Saenz, S.; Nicolis, A.; Penco, R.

    2017-12-01

    We argue that a SO( d) magnetic monopole in an asymptotically AdS space-time is dual to a d-dimensional strongly coupled system in a solid state. In light of this, it would be remiss of us not to dub such a field configuration solidon. In the presence of mixed boundary conditions, a solidon spontaneously breaks translations (among many other symmetries) and gives rise to Goldstone excitations on the boundary — the phonons of the solid. We derive the quadratic action for the boundary phonons in the probe limit and show that, when the mixed boundary conditions preserve conformal symmetry, the longitudinal and transverse sound speeds are related to each other as expected from effective field theory arguments. We then include backreaction and calculate the free energy of the solidon for a particular choice of mixed boundary conditions, corresponding to a relevant multi-trace deformation of the boundary theory. We find such free energy to be lower than that of thermal AdS. This suggests that our solidon undergoes a solid-to-liquid first order phase transition by melting into a Schwarzschild-AdS black hole as the temperature is raised.

  4. Intensity modulated conformal radiotherapy

    International Nuclear Information System (INIS)

    Noel, Georges; Moty-Monnereau, Celine; Meyer, Aurelia; David, Pauline; Pages, Frederique; Muller, Felix; Lee-Robin, Sun Hae; David, Denis Jean

    2006-12-01

    This publication reports the assessment of intensity-modulated conformal radiotherapy (IMCR). This assessment is based on a literature survey which focussed on indications, efficiency and safety on the short term, on the risk of radio-induced cancer on the long term, on the role in the therapeutic strategy, on the conditions of execution, on the impact on morbidity-mortality and life quality, on the impact on the health system and on public health policies and program. This assessment is also based on the opinion of a group of experts regarding the technical benefit of IMCR, its indications depending on the cancer type, safety in terms of radio-induced cancers, and conditions of execution. Before this assessment, the report thus indicates indications for which the use of IMCR can be considered as sufficient or not determined. It also proposes a technical description of IMCR and helical tomo-therapy, discusses the use of this technique for various pathologies or tumours, analyses the present situation of care in France, and comments the identification of this technique in foreign classifications

  5. 6d Conformal matter

    International Nuclear Information System (INIS)

    Zotto, Michele Del; Heckman, Jonathan J.; Tomasiello, Alessandro; Vafa, Cumrun

    2015-01-01

    A single M5-brane probing G, an ADE-type singularity, leads to a system which has G×G global symmetry and can be viewed as “bifundamental” (G,G) matter. For the A N series, this leads to the usual notion of bifundamental matter. For the other cases it corresponds to a strongly interacting (1,0) superconformal system in six dimensions. Similarly, an ADE singularity intersecting the Hořava-Witten wall leads to a superconformal matter system with E 8 ×G global symmetry. Using the F-theory realization of these theories, we elucidate the Coulomb/tensor branch of (G,G ′ ) conformal matter. This leads to the notion of fractionalization of an M5-brane on an ADE singularity as well as fractionalization of the intersection point of the ADE singularity with the Hořava-Witten wall. Partial Higgsing of these theories leads to new 6d SCFTs in the infrared, which we also characterize. This generalizes the class of (1,0) theories which can be perturbatively realized by suspended branes in IIA string theory. By reducing on a circle, we arrive at novel duals for 5d affine quiver theories. Introducing many M5-branes leads to large N gravity duals.

  6. Towards conformal loop quantum gravity

    International Nuclear Information System (INIS)

    Wang, Charles H-T

    2006-01-01

    A discussion is given of recent developments in canonical gravity that assimilates the conformal analysis of gravitational degrees of freedom. The work is motivated by the problem of time in quantum gravity and is carried out at the metric and the triad levels. At the metric level, it is shown that by extending the Arnowitt-Deser-Misner (ADM) phase space of general relativity (GR), a conformal form of geometrodynamics can be constructed. In addition to the Hamiltonian and Diffeomorphism constraints, an extra first class constraint is introduced to generate conformal transformations. This phase space consists of York's mean extrinsic curvature time, conformal three-metric and their momenta. At the triad level, the phase space of GR is further enlarged by incorporating spin-gauge as well as conformal symmetries. This leads to a canonical formulation of GR using a new set of real spin connection variables. The resulting gravitational constraints are first class, consisting of the Hamiltonian constraint and the canonical generators for spin-gauge and conformorphism transformations. The formulation has a remarkable feature of being parameter-free. Indeed, it is shown that a conformal parameter of the Barbero-Immirzi type can be absorbed by the conformal symmetry of the extended phase space. This gives rise to an alternative approach to loop quantum gravity that addresses both the conceptual problem of time and the technical problem of functional calculus in quantum gravity

  7. Benchmarking Commercial Conformer Ensemble Generators.

    Science.gov (United States)

    Friedrich, Nils-Ole; de Bruyn Kops, Christina; Flachsenberg, Florian; Sommer, Kai; Rarey, Matthias; Kirchmair, Johannes

    2017-11-27

    We assess and compare the performance of eight commercial conformer ensemble generators (ConfGen, ConfGenX, cxcalc, iCon, MOE LowModeMD, MOE Stochastic, MOE Conformation Import, and OMEGA) and one leading free algorithm, the distance geometry algorithm implemented in RDKit. The comparative study is based on a new version of the Platinum Diverse Dataset, a high-quality benchmarking dataset of 2859 protein-bound ligand conformations extracted from the PDB. Differences in the performance of commercial algorithms are much smaller than those observed for free algorithms in our previous study (J. Chem. Inf. 2017, 57, 529-539). For commercial algorithms, the median minimum root-mean-square deviations measured between protein-bound ligand conformations and ensembles of a maximum of 250 conformers are between 0.46 and 0.61 Å. Commercial conformer ensemble generators are characterized by their high robustness, with at least 99% of all input molecules successfully processed and few or even no substantial geometrical errors detectable in their output conformations. The RDKit distance geometry algorithm (with minimization enabled) appears to be a good free alternative since its performance is comparable to that of the midranked commercial algorithms. Based on a statistical analysis, we elaborate on which algorithms to use and how to parametrize them for best performance in different application scenarios.

  8. Aplicación del Método de Monte Carlo a la Planificación en Radioterapia y a la Reconstrucción de Espectros de Fotones de Aceleradores Lineales de Partículas (LinAc)

    OpenAIRE

    Juste Vidal, Belen Jeanine

    2011-01-01

    La radioterapia es uno de los tratamientos más generalizados aplicados a los pacientes que padecen determinados tipos de cáncer. Sin embargo, la efectividad de este tipo de tratamientos en la destrucción de las células cancerígenas lleva asociada la posibilidad de sufrir los efectos secundarios de la radiación sobre los tejidos sanos circundantes. El riesgo de lesión de las células sanas depende fundamentalmente de la orientación del haz emitido por la unidad de radioterapia y de la intensida...

  9. Conformal invariance in harmonic superspace

    International Nuclear Information System (INIS)

    Galperin, A.; Ivanov, E.; Ogievetsky, V.; Sokatchev, E.

    1987-01-01

    In the present paper we show how the N = 2 superconformal group is realised in harmonic superspace and examine conformal invariance of N = 2 off-shell theories. We believe that the example of N = O self-dual Yang-Mills equations can serve as an instructive introduction to the subject of harmonic superspace and this is examined. The rigid N = 2 conformal supersymmetry and its local version, i.e. N = 2 conformal supergravity is also discussed. The paper is a contribution to the book commemorating the sixtieth birthday of E.S. Fradkin. (author)

  10. Two dimensional infinite conformal symmetry

    International Nuclear Information System (INIS)

    Mohanta, N.N.; Tripathy, K.C.

    1993-01-01

    The invariant discontinuous (discrete) conformal transformation groups, namely the Kleinian and Fuchsian groups Gamma (with an arbitrary signature) of H (the Poincare upper half-plane l) and the unit disc Delta are explicitly constructed from the fundamental domain D. The Riemann surface with signatures of Gamma and conformally invariant automorphic forms (functions) with Peterson scalar product are discussed. The functor, where the category of complex Hilbert spaces spanned by the space of cusp forms constitutes the two dimensional conformal field theory. (Author) 7 refs

  11. Harmony of spinning conformal blocks

    Energy Technology Data Exchange (ETDEWEB)

    Schomerus, Volker [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Theory Group; Sobko, Evgeny [Stockholm Univ. (Sweden); Nordita, Stockholm (Sweden); Isachenkov, Mikhail [Weizmann Institute of Science, Rehovoth (Israel). Dept. of Particle Physics and Astrophysics

    2016-12-07

    Conformal blocks for correlation functions of tensor operators play an increasingly important role for the conformal bootstrap programme. We develop a universal approach to such spinning blocks through the harmonic analysis of certain bundles over a coset of the conformal group. The resulting Casimir equations are given by a matrix version of the Calogero-Sutherland Hamiltonian that describes the scattering of interacting spinning particles in a 1-dimensional external potential. The approach is illustrated in several examples including fermionic seed blocks in 3D CFT where they take a very simple form.

  12. Harmony of spinning conformal blocks

    Energy Technology Data Exchange (ETDEWEB)

    Schomerus, Volker [DESY Hamburg, Theory Group,Notkestraße 85, 22607 Hamburg (Germany); Sobko, Evgeny [Nordita and Stockholm University,Roslagstullsbacken 23, SE-106 91 Stockholm (Sweden); Isachenkov, Mikhail [Department of Particle Physics and Astrophysics, Weizmann Institute of Science,Rehovot 7610001 (Israel)

    2017-03-15

    Conformal blocks for correlation functions of tensor operators play an increasingly important role for the conformal bootstrap programme. We develop a universal approach to such spinning blocks through the harmonic analysis of certain bundles over a coset of the conformal group. The resulting Casimir equations are given by a matrix version of the Calogero-Sutherland Hamiltonian that describes the scattering of interacting spinning particles in a 1-dimensional external potential. The approach is illustrated in several examples including fermionic seed blocks in 3D CFT where they take a very simple form.

  13. Mass generation within conformal invariant theories

    International Nuclear Information System (INIS)

    Flato, M.; Guenin, M.

    1981-01-01

    The massless Yang-Mills theory is strongly conformally invariant and renormalizable; however, when masses are introduced the theory becomes nonrenormalizable and weakly conformally invariant. Conditions which recover strong conformal invariance are discussed in the letter. (author)

  14. Logarithmic conformal field theory

    Science.gov (United States)

    Gainutdinov, Azat; Ridout, David; Runkel, Ingo

    2013-12-01

    Conformal field theory (CFT) has proven to be one of the richest and deepest subjects of modern theoretical and mathematical physics research, especially as regards statistical mechanics and string theory. It has also stimulated an enormous amount of activity in mathematics, shaping and building bridges between seemingly disparate fields through the study of vertex operator algebras, a (partial) axiomatisation of a chiral CFT. One can add to this that the successes of CFT, particularly when applied to statistical lattice models, have also served as an inspiration for mathematicians to develop entirely new fields: the Schramm-Loewner evolution and Smirnov's discrete complex analysis being notable examples. When the energy operator fails to be diagonalisable on the quantum state space, the CFT is said to be logarithmic. Consequently, a logarithmic CFT is one whose quantum space of states is constructed from a collection of representations which includes reducible but indecomposable ones. This qualifier arises because of the consequence that certain correlation functions will possess logarithmic singularities, something that contrasts with the familiar case of power law singularities. While such logarithmic singularities and reducible representations were noted by Rozansky and Saleur in their study of the U (1|1) Wess-Zumino-Witten model in 1992, the link between the non-diagonalisability of the energy operator and logarithmic singularities in correlators is usually ascribed to Gurarie's 1993 article (his paper also contains the first usage of the term 'logarithmic conformal field theory'). The class of CFTs that were under control at this time was quite small. In particular, an enormous amount of work from the statistical mechanics and string theory communities had produced a fairly detailed understanding of the (so-called) rational CFTs. However, physicists from both camps were well aware that applications from many diverse fields required significantly more

  15. Higher-derivative generalization of conformal mechanics

    Science.gov (United States)

    Baranovsky, Oleg

    2017-08-01

    Higher-derivative analogs of multidimensional conformal particle and many-body conformal mechanics are constructed. Their Newton-Hooke counterparts are derived by applying appropriate coordinate transformations.

  16. Naturality in conformal field theory

    International Nuclear Information System (INIS)

    Moore, G.; Seiberg, N.

    1989-01-01

    We discuss constraints on the operator product coefficients in diagonal and nondiagonal rational conformal field theories. Nondiagonal modular invariants always arise from automorphisms of the fusion rule algebra or from extensions of the chiral algebra. Moreover, when the chiral algebra has been maximally extended a strong form of the naturality principle of field theory can be proven for rational conformal field theory: operator product coefficients vanish if and only if the corresponding fusion rules vanish; that is, if and only if the vanishing can be understood in terms of a symmetry. We illustrate these ideas with several examples. We also generalize our ideas about rational conformal field theories to a larger class of theories: 'quasi-rational conformal field theories' and we explore some of their properties. (orig.)

  17. Steady states in conformal theories

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    A novel conjecture regarding the steady state behavior of conformal field theories placed between two heat baths will be presented. Some verification of the conjecture will be provided in the context of fluid dynamics and holography.

  18. National Automated Conformity Inspection Process -

    Data.gov (United States)

    Department of Transportation — The National Automated Conformity Inspection Process (NACIP) Application is intended to expedite the workflow process as it pertains to the FAA Form 81 0-10 Request...

  19. Aspect of the conformal invariance

    International Nuclear Information System (INIS)

    Bauer, M.

    1990-11-01

    This thesis is about the study of several physical and mathematical aspects of critical phenomena at two dimensions. These phenomena have remarkable symmetry properties in the coordonnates changes keeping the angles. They are named conformal theories

  20. Some Progress in Conformal Geometry

    Directory of Open Access Journals (Sweden)

    Sun-Yung A. Chang

    2007-12-01

    Full Text Available This is a survey paper of our current research on the theory of partial differential equations in conformal geometry. Our intention is to describe some of our current works in a rather brief and expository fashion. We are not giving a comprehensive survey on the subject and references cited here are not intended to be complete. We introduce a bubble tree structure to study the degeneration of a class of Yamabe metrics on Bach flat manifolds satisfying some global conformal bounds on compact manifolds of dimension 4. As applications, we establish a gap theorem, a finiteness theorem for diffeomorphism type for this class, and diameter bound of the $sigma_2$-metrics in a class of conformal 4-manifolds. For conformally compact Einstein metrics we introduce an eigenfunction compactification. As a consequence we obtain some topological constraints in terms of renormalized volumes.

  1. Conformity Adequacy Review: Region 5

    Science.gov (United States)

    Resources are for air quality and transportation government and community leaders. Information on the conformity SIP adequacy/inadequacy of state implementation plans (SIPs) in EPA Region 5 (IL, IN, MI, OH, WI) is provided here.

  2. Inverse bootstrapping conformal field theories

    Science.gov (United States)

    Li, Wenliang

    2018-01-01

    We propose a novel approach to study conformal field theories (CFTs) in general dimensions. In the conformal bootstrap program, one usually searches for consistent CFT data that satisfy crossing symmetry. In the new method, we reverse the logic and interpret manifestly crossing-symmetric functions as generating functions of conformal data. Physical CFTs can be obtained by scanning the space of crossing-symmetric functions. By truncating the fusion rules, we are able to concentrate on the low-lying operators and derive some approximate relations for their conformal data. It turns out that the free scalar theory, the 2d minimal model CFTs, the ϕ 4 Wilson-Fisher CFT, the Lee-Yang CFTs and the Ising CFTs are consistent with the universal relations from the minimal fusion rule ϕ 1 × ϕ 1 = I + ϕ 2 + T , where ϕ 1 , ϕ 2 are scalar operators, I is the identity operator and T is the stress tensor.

  3. Nutrition screening by MUST on the oncological patient in radiotherapy; Triagem nutricional por meio do MUST para paciente oncologico em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Paula Acevedo Souza dos; Cunha, Tamires Regina da Silva; Soares, Bruna Lucia de Mendonca; Maio, Regiane; Burgos, Maria Goretti Pessoa de Araujo, E-mail: paulaacevedosouza@gmail.com, E-mail: tamires_rsc@hotmail.com, E-mail: bruna-luc@hotmail.com [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Departamento de Nutricao; Cabral, Edla Karina, E-mail: edla_cabral@hotmail.com [Hospital de Cancer de Pernambuco, Recife, PE (Brazil)

    2016-11-01

    Introduction: Radiotherapy contributes to the reduction of food intake and increased weight loss due to the appearance of gastrointestinal symptoms, which consequently leads to malnutrition. Objective: Identify nutritional risk through the Malnutrition Universal Screening Tool (MUST), in patients submitted to radiotherapy for the treatment of cancer. Method: Cross-sectional study with outpatients at the radiotherapy service of the Cancer Hospital of Pernambuco, during October 2014 until May 2015. Socio-demographic characteristics, lifestyle (smoking, alcohol use and physical activity), anthropometric variables (habitual weight, current weight and body mass index), comorbidities (hypertension and diabetes), tumor type, time since diagnosis and duration of treatment were evaluated. Nutritional risk was assessed using the MUST, which classifies patients as being at low, medium or high nutritional risk. Results: 150 patients were studied with an average age of 47.3 years, with a predominance of women (72%) and similar proportions of adults and elderly individuals. The sample mainly comprised individuals from in-state regions and inactive/retired individuals who received one to three times the minimum salary. Nutritional risk was significantly higher among elderly individuals (62.9%), among whom high risk predominated (45.7%), whereas most adults had no risk (61.2%). The most frequent tumors were gynecological (59.4%) with weight gain (33.3%), followed by tumors of the head and neck region with a high degree of weight loss (p = 0.007). Conclusion: The use of MUST led to the detection of nutritional risk in 50% of the studied patients, with a predominance of elderly individuals, the majority of whom were at high risk. Tumors of the head and neck led to weight loss, whereas gynecological tumors led to weight gain. Out-patient nutritional screening is important for the early establishment of specialized nutritional counseling. (author)

  4. A radioterapia profunda em doses elevadas na epilepsia focal: contrôle clínico e eletrencefalográfico

    Directory of Open Access Journals (Sweden)

    Paulo Pinto Pupo

    1954-06-01

    Full Text Available Radiotherapy in high doses has been used in cases of symptomatic epilepsy with the purpose of to act against the focal epileptic activity, as coadjuvancy to the common medical treatment. Patients with clinical manifestations of epilepsy in whom convulsive foci were demonstrated in the EEG, have been selected; these foci have been recognized as well localized and well circunscribed, and in all them the etiology has been the same (atrophic lesions, according to the clinical and radiological (craniogram, pneumoencephalogram and arteriogram examinations. The purpose of a so homogenous group was to study the results to be obtained in similar conditions. Twenty patients have been selected from a group of forty-eight, because it was possible to obtain a good follow-up for at least three months in each case. In all cases, a medical treatment (barbiturate plus hidantoi-nate has been used in uniform manner, with the purpose of avoiding influence on the judgement of the value of radiotherapy, for it was impossible to interrupt the drug therapy. Radiotherapy has been used in high doses over the epileptic lesion, which had been localized by the EEG. Two different techniques were used; in both 200 kv, 0.5 mm. filter of Cu were employed. Fourteen patients were irradiated in four different areas, of 4 cm. in diameter each one; they received 150 r daily, 2 areas by day, performing an average total of 3,000 r. In the other 6 cases the technique of kinetic convergent radiotherapy was employed, using the Siemens apparatus; each patient received, through a cutaneous area, an average doses of 3,000 r into the focus and 2,000 r in the skin; they received from 100 r to 150 r in the focus daily. Studying the twenty cases individually, there was marked EEG improvement in 4, relative improvement in 8 and no change in 8; there was marked decrease in the number of seizures in 8, relative decrease in 10 and no change in 2; the mental status was markedly improved in 7, relatively improved in 6 and not changed in 7. The authors call attentiori to the following points: a Radiotherapy seems to act directyl over the focal electric activity, for there was marked improvement in 4 cases, and relative improvement in 8 cases, immediately after its use; in 2 cases there was exacerbation of the focal activity later; b In all cases there was decrease in the number of seizures just after radiotherapy; it was not possible, however, to associate this improvement only to radiotherapy, for there was increase of seizures in 2 patients when medical treatment was stopped; c There was improvement of mental status in 13 cases, although it is important to remember that there was also improvement of the cerebral physiology due to the decrease in number of seizures and improvement of the emotional status of the patient related to their better clinical conditions; d There was no relation between the number of seizures and focal activity evidenced by the EEG; e There was no relation between the intensity of cerebral focal activity and the mental status of the patient. The authors conclude: 1 Radiotherapy in high doses decrease the epileptic cerebral focal activity; 2 It is impossible to affirm that the clinical improvement is due to radiotherapy only; 2 patients had increase of focal activity far away from radiotherapy, and 2 others presented increase in the number of seizures when medical treatment was discontinued.

  5. Local dose enhancement in radiation therapy: Monte Carlo simulation study; Reforco local de dose em radioterapia utilizando nanoparticulas: estudo por simulacao Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Laura E. da; Nicolucci, Patricia, E-mail: laura.emilia.fm@gmail.com [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Faculdade de Filosofia, Ciencias e Letras

    2014-04-15

    The development of nanotechnology has boosted the use of nanoparticles in radiation therapy in order to achieve greater therapeutic ratio between tumor and healthy tissues. Gold has been shown to be most suitable to this task due to the high biocompatibility and high atomic number, which contributes to a better in vivo distribution and for the local energy deposition. As a result, this study proposes to study, nanoparticle in the tumor cell. At a range of 11 nm from the nanoparticle surface, results have shown an absorbed dose 141 times higher for the medium with the gold nanoparticle compared to the water for an incident energy spectrum with maximum photon energy of 50 keV. It was also noted that when only scattered radiation is interacting with the gold nanoparticles, the dose was 134 times higher compared to enhanced local dose that remained significant even for scattered radiation. (author)

  6. Development of phosphate glass microspheres containing holmium for selective internal radiotherapy; Desenvolvimento de microesferas de vidro fosfato contendo holmio para uso em radioterapia interna seletiva

    Energy Technology Data Exchange (ETDEWEB)

    Barros Filho, Eraldo Cordeiro

    2016-11-01

    The selective internal radiotherapy is an alternative for some kinds of cancer as the hepatocellular carcinoma (HCC) or primary liver cancer treatment. In this treatment, glass or polymer microspheres containing radionuclides inside their structure are introduced in the liver through hepatic artery and trapped at the arterioles that feed the tumor. In this work, the development of phosphate glasses containing holmium for production of microspheres and their application in Brazil are proposed. The developed glasses presented suitable chemical durability, density of 2,7(3) g/cm{sup 3}, high thermal stability and the impurities contained therein do not preclude the treatment. The microspheres were produced by the flame method and the gravitational fall method, and were characterized by means of several techniques to evaluate shape, average particle size, activity and biocompatibility suitable for selective internal radiotherapy. Based in the main results, the submission to in vivo tests is proposed. (author)

  7. Development of a model for recording and evaluating incidents in radiotherapy; Desenvolvimento de um modelo para registro e avaliação de incidentes em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, A.L.C.; Paiva, E. de, E-mail: andhreluiz@gmail.com [Instituto de Radioproteção e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Div. de Física Médica; Teixeira, F.C.S. [Comissão Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil). Div. de Aplicações Médicas e Pesquisa

    2017-07-01

    Radiotherapy has been constantly improving to become increasingly effective, thus contributing to increase the chances of healing patients. In this sense, incident learning gained prominence during successive approaches to patient safety. The objective is to develop a tool for recording and analyzing incidents in radiotherapy and applying it to clinics in Rio de Janeiro in order to implement the policy of quality management and safety culture. Steps were taken that involved the analysis of the process maps for the enrichment of the system (called the Standardized System of Incidents in Radiotherapy - SPIRad) that already has a version in physical form. The proposal is the conversion of this form to a digital tool to be used through the intranet. The next step is to apply it to radiotherapy clinics in Rio de Janeiro and evaluate the results obtained with the objective of possible improvements through feedback from users.

  8. Study for the development of a standardized system of incidents in radiotherapy; Estudo para desenvolvimento de um sistema Institucional padronizado de incidentes em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro, A.LC.; Silva, A.L. da; Moreira, J.G.R.; Silva, K.R.R. da, E-mail: andhreluiz@gmail.com, E-mail: arnaldolimasilva@yahoo.com.br, E-mail: josegustavo.rmoreira@gmail.com, E-mail: karine.ramosrocha@gmail.com [Universidade do Grande Rio (UNIGRANRIO), Duque de Caxias, RJ (Brazil). Tecnologia em Radiologia; Teixeira, F.C.S., E-mail: flavia@cnen.gov.br [Comissão Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil)

    2017-07-01

    Radiotherapy is a modality that, along with surgery, has become essential for the success of cancer treatment. Over the years, radiotherapy has been improved to increase the effectiveness of the chances of cure. The objective of this study was to capture data from on-site visits in two clinics that offer the radiotherapy service in the state of Rio de Janeiro. After observing that each clinic had similar procedures, however, with some different methods and in view of these data obtained, a model was developed for an institutional system of incident record with the purpose of sharing results to assist in the improvement of safety protocols to mitigate possible accidents in one or more units. We conclude that this system has everything to fulfill the proposal of assisting in learning incidents. However, it is primary and updates will be of utmost importance for your improvement.

  9. Evaluation of thermoluminescent BeO samples in standard radiotherapy beams; Avaliacao de amostras termoluminescentes de BeO em feixes padroes de radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Groppo, Daniela P.; Silva, Jonas O.; Caldas, Linda V.E., E-mail: daniela.piai.groppo@gmail.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2012-08-15

    Beryllium oxide thermoluminescent samples were evaluated in standard radiotherapy beams of low energy. Results for response reproducibility, dose-response curve and energy dependence were obtained. The lower detection limit was determined. The pellets of BeO showed their usefulness for beam dosimetry. (author)

  10. Characterization of an electronic system for Image acquisition portal to open field dosimetry; Caracterizacao de um sistema eletronico de aquisicao de imagem portal para dosimetria em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Barbi, Gustavo L.; Oliveira, Harley F.; Bertucci, Edenyse C.; Amaral, Leonardo L.; Borges, Leandro F., E-mail: gustavobarbi@usp.br [Universidade de Sao Paulo (USP), Ribeirao Preto, SP (Brazil). Hospital das Clinicas. Centro de Ciencias das Imagens e Fisica Medica

    2012-08-15

    The objective was to characterize and enable an electronic portal imaging device (EPID) to use like a portal dosimetry device - PDI, in non-transit mode, without interposition of scattering between the beam and EPID for measurement to open fields. The images as well as the DICOM header data are extracted from software ImageJ and the information are used in the basic algorithm for converting pixel to dose. The linearity and reproducibility of response were analyzed, and the maximum deviation found of 2,3% to 800 monitor units (MU) for linearity and -0,9% for reproducibility of signal measured daily. A 512x512 matrix with a resolution of 0,8mm was established to restore the shape of beam from the image. The field size dependence was evaluated, by obtaining the ratio of total scattering of ionization chamber and EPID. Finally, a calibration factor of 28470.88{+-}170.73 pixel/cGy was established for the central area of the image. Comparative analyzes between the PDI, radiochromic film and array of ionization chambers (MatriXX) showed good agreement for fields greater then 5 x 5 cm{sup 2} to reestablishment of form field and dose, however, for fields between 3x3 cm{sup 2} and 5x5 cm{sup 2}, the agreement to shape of beam was best established by film. (author)

  11. Dosimetric properties characterization of silicon diodes used in photon beam radiotherapy; Caracterizacao das propriedades dosimetricas de diodos de silicio empregados em radioterapia com feixe de fotons

    Energy Technology Data Exchange (ETDEWEB)

    Bizetto, Cesar Augusto

    2013-07-01

    In the current work it was studied the performance of epitaxial (EPI) and float zone (FZ) silicon diodes as on-line dosimeters for megavoltage (EPI diode) and orthovoltage (EPI and FZ diode) photon beam radiotherapy. In order to be used as dosimeters the diodes were enclosed in black polymethylmethacrylate (PMMA) probes. The devices were then connected, on photovoltaic mode, to an electrometer Keithley Registered-Sign 6517B to allow measurements of the photocurrent. The irradiations were performed with 6 and 18 MV photon beams (Siemens Primus Registered-Sign linear accelerator), 6 and 15 MV (Novalis TX Registered-Sign ) and 10, 25, 30 and 50 kV of a Pantak / Seifert X ray radiation device. During the measurements with the Siemens Primus the diodes were held between PMMA plates placed at 10.0 cm depth. When using Novalis TX Registered-Sign the devices were held between solid water plates placed at 50 cm depth. In both cases the diodes were centered in a radiation field of 10 x 10 cm{sup 2}, with the source-to-surface distance (SSD) kept at 100 cm. In measurements with orthovoltage photon beams the diodes were placed 50.0 cm from the tube in a radiation field of 8 cm diameter. The dose-rate dependency was studied for 6 and 15 MV (varying the dose-rate from 100 to 600 monitor units per minute) and for the 50 kV beam by varying the current tube from 2 to 20 mA. All devices showed linear response with dose rate and, within uncertainties the charge collected is independent of dose rate. The current signals induced showed good instantaneous repeatability of the diodes, characterized by coefficients of variation of current (CV) smaller than 1.14% (megavoltage beams) and 0.15% for orthovoltage beams and coefficients of variation of charge (CV) smaller than 1.84% (megavoltage beams) and 1.67% (orthovoltage beams). The dose response curves were quite linear with linear correlation coefficients better than 0.9999 for all diodes. (author)

  12. Dosimetric properties characterization of silicon diodes used in photon beam radiotherapy; Caracterizacao das propriedades dosimetricas de diodos de silicio empregados em radioterapia com fotons

    Energy Technology Data Exchange (ETDEWEB)

    Bizetto, Cesar Augusto

    2013-07-01

    In the current work it was studied the performance of epitaxial (EPI) and float zone (FZ) silicon diodes as on-line dosimeters for megavoltage (EPI diode) and orthovoltage (EPI and FZ diode) photon beam radiotherapy. In order to be used as dosimeters the diodes were enclosed in black polymethylmethacrylate (PMMA) probes. The devices were then connected, on photovoltaic mode, to an electrometer KeithleyÒ 6517B to allow measurements of the photocurrent. The irradiations were performed with 6 and 18 MV photon beams (Siemens PrimusÒ linear accelerator), 6 and 15 MV (Novalis TXÒ) and 10, 25, 30 and 50 kV of a Pantak / Seifert X ray radiation device. During the measurements with the Siemens PrimusÒ the diodes were held between PMMA plates placed at 10.0 cm depth. When using Novalis TXÒ the devices were held between solid water plates placed at 50 cm depth. In both cases the diodes were centered in a radiation field of 10 x 10 cm{sup 2}, with the source-to-surface distance (SSD) kept at 100 cm. In measurements with orthovoltage photon beams the diodes were placed 50.0 cm from the tube in a radiation field of 8 cm diameter. The dose-rate dependency was studied for 6 and 15 MV (varying the dose-rate from 100 to 600 monitor units per minute) and for the 50 kV beam by varying the current tube from 2 to 20 mA. All devices showed linear response with dose rate and, within uncertainties the charge collected is independent of dose rate. The current signals induced showed good instantaneous repeatability of the diodes, characterized by coefficients of variation of current (CV) smaller than 1.14% (megavoltage beams) and 0.15% for orthovoltage beams and coefficients of variation of charge (CV) smaller than 1.84% (megavoltage beams) and 1.67% (orthovoltage beams). The dose response curves were quite linear with linear correlation coefficients better than 0.9999 for all diodes. (author)

  13. Clinical and biochemical evaluation of the saliva of patients with xerostomia induced by radiotherapy Avaliação clínica e bioquímica da saliva de pacientes com xerostomia induzida por radioterapia

    Directory of Open Access Journals (Sweden)

    Cássio de Barros Pontes

    2004-03-01

    Full Text Available Clinical aspects and biochemical properties in the saliva of 21 patients prior to and following radiotherapy for head and neck cancer were evaluated (experimental group and compared with the same properties in a control group of 21 subjects free of cancer. Salivary flow was evaluated by measuring the time necessary, in seconds, for the output of 2 ml of stimulated saliva; and the buffering capacity changes were determined using a simple colorimetric method. Total salivary protein concentration was determined by the Bradford4 method. Amylase activity was measured by reducing sugars released from a soluble starch substrate, quantified by the dinitrosalicylic method. The electrophoretic profile was evaluated in polyacrylamid gel (12% SDS-PAGE using samples of 5 mg of salivary protein. A statistically significant reduction (p Foram avaliados alguns aspectos clínicos e algumas propriedades bioquímicas salivares de 21 pacientes, antes e após o tratamento radioterápico para câncer de cabeça e pescoço (grupo experimental e de 21 pacientes sem câncer (grupo controle. O fluxo salivar foi avaliado pelo tempo necessário (segundos para produção estimulada de 2 ml de saliva e a capacidade tamponante determinada frente à utilização de um método colorimétrico simples. A concentração de proteína total salivar foi determinada pelo método de Bradford4. A atividade da amilase foi mensurada através dos açúcares redutores liberados e quantificados pelo método do ácido dinitrossalicílico utilizando a glicose como substrato. O perfil eletroforético foi avaliado em gel de poliacrilamida (SDS-PAGE 12% para amostras salivares contendo 5 mg de proteína. Foi observada, no grupo experimental, redução estatisticamente significativa (p < 0,01 para o fluxo salivar (162,47 s ± 28,30 antes e 568,71 s ± 79,75 após e para a capacidade tamponante (pH 5,45 ± 0,14 antes e 4,40 ± 0,15 após. Não foi observada alteração estatisticamente

  14. Conformal radiotherapy: principles and classification

    International Nuclear Information System (INIS)

    Rosenwald, J.C.; Gaboriaud, G.; Pontvert, D.

    1999-01-01

    'Conformal radiotherapy' is the name fixed by usage and given to a new form of radiotherapy resulting from the technological improvements observed during the last ten years. While this terminology is now widely used, no precise definition can be found in the literature. Conformal radiotherapy refers to an approach in which the dose distribution is more closely 'conformed' or adapted to the actual shape of the target volume. However, the achievement of a consensus on a more specific definition is hampered by various difficulties, namely in characterizing the degree of 'conformality'. We have therefore suggested a classification scheme be established on the basis of the tools and the procedures actually used for all steps of the process, i.e., from prescription to treatment completion. Our classification consists of four levels: schematically, at level 0, there is no conformation (rectangular fields); at level 1, a simple conformation takes place, on the basis of conventional 2D imaging; at level 2, a 3D reconstruction of the structures is used for a more accurate conformation; and level 3 includes research and advanced dynamic techniques. We have used our personal experience, contacts with colleagues and data from the literature to analyze all the steps of the planning process, and to define the tools and procedures relevant to a given level. The corresponding tables have been discussed and approved at the European level within the Dynarad concerted action. It is proposed that the term 'conformal radiotherapy' be restricted to procedures where all steps are at least at level 2. (author)

  15. Conformal Cosmology and Supernova Data

    OpenAIRE

    Behnke, Danilo; Blaschke, David; Pervushin, Victor; Proskurin, Denis

    2000-01-01

    We define the cosmological parameters $H_{c,0}$, $\\Omega_{m,c}$ and $\\Omega_{\\Lambda, c}$ within the Conformal Cosmology as obtained by the homogeneous approximation to the conformal-invariant generalization of Einstein's General Relativity theory. We present the definitions of the age of the universe and of the luminosity distance in the context of this approach. A possible explanation of the recent data from distant supernovae Ia without a cosmological constant is presented.

  16. Scalar perturbations and conformal transformation

    International Nuclear Information System (INIS)

    Fabris, J.C.; Tossa, J.

    1995-11-01

    The non-minimal coupling of gravity to a scalar field can be transformed into a minimal coupling through a conformal transformation. We show how to connect the results of a perturbation calculation, performed around a Friedman-Robertson-Walker background solution, before and after the conformal transformation. We work in the synchronous gauge, but we discuss the implications of employing other frames. (author). 16 refs

  17. Idade como fator prognóstico no câncer de mama em estádio inicial Edad como factor pronóstico en el cáncer de mama en fase inicial Age as a prognostic factor in early breast cancer

    Directory of Open Access Journals (Sweden)

    Bernardo Garicochea

    2009-04-01

    Full Text Available OBJETIVO: Analisar a idade como fator prognóstico no câncer de mama em estádio clínico inicial. MÉTODOS: Estudo retrospectivo que analisou as características clínicas e a sobrevida livre de doença de 280 pacientes entre 25 e 81 anos com câncer de mama estágio clínico I e II com acompanhamento em hospital de Porto Alegre (RS, de 1995 a 2000. Dados clínicos, patológicos, tratamento e desfechos foram extraídos dos prontuários das pacientes. As pacientes foram divididas em dois grupos conforme a idade ao diagnóstico (40 anos. Os dois grupos foram comparados quanto ao estágio clínico, histologia, expressão de receptores hormonais, terapia e radioterapia utilizando o teste qui-quadrado e/ou exato de Fisher e para análise de sobrevida, o teste de long-rank e método de Kaplan-Meier. RESULTADOS: Do total de 280 mulheres estudadas, 54 (19,3% tinham até 40 anos de idade. Ambos os grupos de pacientes eram similares em estágio clínico, histologia e expressão de receptores hormonais. A proporção de pacientes com sobrevida livre de doença em seguimento de 56 meses foi significativamente maior nas pacientes acima de 40 anos (84% versus 70%. Proporcionalmente, as pacientes mais jovens receberam mais terapia adjuvante (88,8% versus 77,8%. Houve diferença significativa na probabilidade das mulheres acima de 40 anos de permanecerem livre de doença (84%, sendo mais evidente quando comparadas às pacientes com OBJETIVO: Analizar la edad como factor pronóstico en el cáncer de mama en fase clínico inicial. MÉTODOS: Estudio retrospectivo que analizó las características clínicas y la sobrevida libre de enfermedad de 280 pacientes entre 25 y 81 años con cáncer de mama fase clínica I y II con acompañamiento en hospital de Porto Alegre (Sur de Brasil, de 1995 a 2000. Datos clínicos, patológicos, tratamiento y resultados fueron extraídos de los prontuarios de las pacientes. Las pacientes fueron divididas en dos grupos conforme la

  18. Descriptive study of breast and cervix cancer, in patients treated with linear accelerator, at the Centro Medico de Radioterapia Irazu, between 2000 and 2001, and proposed a database

    International Nuclear Information System (INIS)

    Calvo Jimenez, Kattia; Marchena Mendoza, Mario

    2008-01-01

    A descriptive study of breast and cervix cancer was performed in patients who have received treatment linear accelerator, during the period 2000 - 2001 in the Centro Medico de Radioterapia Irazu. The survival of the patients was assessed to five years (2006). One proposal called database is the product of analysis performed and consistent with the objectives set. The idea to develop the database of these features in the medical center, arises because the Centre was at that time with the only linear accelerator in the country and also all the necessary information of patients was easily accessible. A population of 438 records, with a common pathology was analyzed under the following variables: type of cancer, identification of anatomic region, province, age, sex, type of radiation, number of sessions, referral hospital, physician, physician referral. This work is relevant, because breast and cervical cancers have been a major cause of mortality, ranked among the five most common malignancies in women. From there to have adequate information systems, has led policy makers and health professionals to have a better outlook for their level of management. (author) [es

  19. Análise da distribuição espacial de dose absorvida em próton terapia ocular Spatial distribution analysis of absorbed dose in ocular proton radiation therapy

    Directory of Open Access Journals (Sweden)

    Marília Tavares Christóvão

    2010-08-01

    Full Text Available OBJETIVO: Propõe-se avaliar os perfis de dose em profundidade e as distribuições espaciais de dose para protocolos de radioterapia ocular por prótons, a partir de simulações computacionais em código nuclear e modelo de olho discretizado em voxels. MATERIAIS E MÉTODOS: As ferramentas computacionais empregadas foram o código Geant4 (GEometry ANd Tracking Toolkit e o SISCODES (Sistema Computacional para Dosimetria em Radioterapia. O Geant4 é um pacote de software livre, utilizado para simular a passagem de partículas nucleares com carga elétrica através da matéria, pelo método de Monte Carlo. Foram executadas simulações computacionais reprodutivas de radioterapia por próton baseada em instalações pré-existentes. RESULTADOS: Os dados das simulações foram integrados ao modelo de olho através do código SISCODES, para geração das distribuições espaciais de doses. Perfis de dose em profundidade reproduzindo o pico de Bragg puro e modulado são apresentados. Importantes aspectos do planejamento radioterápico com prótons são abordados, como material absorvedor, modulação, dimensões do colimador, energia incidente do próton e produção de isodoses. CONCLUSÃO: Conclui-se que a terapia por prótons, quando adequadamente modulada e direcionada, pode reproduzir condições ideais de deposição de dose em neoplasias oculares.OBJECTIVE: The present study proposes the evaluation of the depth-dose profiles and the spatial distribution of radiation dose for ocular proton beam radiotherapy protocols, based on computer simulations in nuclear codes and an eye model discretized into voxels. MATERIALS AND METHODS: The employed computational tools were Geant4 (GEometry ANd Tracking Toolkit and SISCODES (Sistema Computacional para Dosimetria em Radioterapia - Computer System for Dosimetry in Radiotherapy. Geant4 is a toolkit for simulating the passage of particles through the matter, based on Monte Carlo method. Computer simulations

  20. Quantum Conformal Algebras and Closed Conformal Field Theory

    CERN Document Server

    Anselmi, D

    1999-01-01

    We investigate the quantum conformal algebras of N=2 and N=1 supersymmetric gauge theories. Phenomena occurring at strong coupling are analysed using the Nachtmann theorem and very general, model-independent, arguments. The results lead us to introduce a novel class of conformal field theories, identified by a closed quantum conformal algebra. We conjecture that they are the exact solution to the strongly coupled large-N_c limit of the open conformal field theories. We study the basic properties of closed conformal field theory and work out the operator product expansion of the conserved current multiplet T. The OPE structure is uniquely determined by two central charges, c and a. The multiplet T does not contain just the stress-tensor, but also R-currents and finite mass operators. For this reason, the ratio c/a is different from 1. On the other hand, an open algebra contains an infinite tower of non-conserved currents, organized in pairs and singlets with respect to renormalization mixing. T mixes with a se...

  1. Percentage of pathological complete response in patients with rectal cancer that received neoadjuvant therapy with chemotherapy and radiotherapy at the Servicio de Radioterapia from Hospital Mexico, in the period from January 2009 to December 2013

    International Nuclear Information System (INIS)

    Lopez Mena, Stephanie

    2015-01-01

    Percentage of pathologic complete response is determined in patients with rectal cancer, treated with neoadjuvant chemotherapy and radiotherapy, in the Servicio de Radioterapia from Hospital Mexico, in the period between January 2009 and December 2013. Tumor histology is determined. The distance of the tumor is identified with respect to the anal margin. The correlation between the TNM staging and the response received in this type of neoadjuvant therapy is described. Radiotherapy dose used in each case is described. Different schemes of chemotherapy used are characterized. The acute side effects most common are determined in the study population [es

  2. Carcinoma espinocelular em couro cabeludo inicialmente diagnosticado como queratoacantoma

    Directory of Open Access Journals (Sweden)

    Priscila Wolf Nassif

    2010-03-01

    Full Text Available O queratoacantoma pode com muita facilidade ser confundido com carcinoma espinocelular, tanto clínica quanto histopatologicamente. Só o queratoacantoma, entretanto, pode regredir de maneira espontânea. Relata-se caso de paciente com lesão exofídica, ulcerada e infiltrada em couro cabeludo previamente diagnosticada como queratoacantoma. O exame histopatológico confirmou carcinoma espinocelular, e a tomografia de crânio evidenciou invasão da calota craniana. Procedeu-se à excisão cirúrgica com margens amplas e confecção de retalho de rotação, seguida de tratamento adjuvante com quimioterapia e radioterapia. Há muitos relatos na literatura de carcinomas espinocelulareserroneamente diagnosticados como queratoacantomas demonstrando a dificuldade nessa diferenciação. Enquanto não se estabelecem métodos eficazes para distinguir as duas entidades, o tratamento de escolha deve ser a excisão cirúrgica.

  3. Gauge fixing problem in the conformal QED

    International Nuclear Information System (INIS)

    Ichinose, Shoichi

    1986-01-01

    The gauge fixing problem in the conformal (spinor and scalar) QED is examined. For the analysis, we generalize Dirac's manifestly conformal-covariant formalism. It is shown that the (vector and matter) fields must obey a certain mixed (conformal and gauge) type of transformation law in order to fix the local gauge symmetry preserving the conformal invariance in the Lagrangian. (orig.)

  4. 40 CFR 93.154 - Conformity analysis.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Conformity analysis. 93.154 Section 93...) DETERMINING CONFORMITY OF FEDERAL ACTIONS TO STATE OR FEDERAL IMPLEMENTATION PLANS Determining Conformity of General Federal Actions to State or Federal Implementation Plans § 93.154 Conformity analysis. Any Federal...

  5. Conformational Clusters of Phosphorylated Tyrosine.

    Science.gov (United States)

    Abdelrasoul, Maha; Ponniah, Komala; Mao, Alice; Warden, Meghan S; Elhefnawy, Wessam; Li, Yaohang; Pascal, Steven M

    2017-12-06

    Tyrosine phosphorylation plays an important role in many cellular and intercellular processes including signal transduction, subcellular localization, and regulation of enzymatic activity. In 1999, Blom et al., using the limited number of protein data bank (PDB) structures available at that time, reported that the side chain structures of phosphorylated tyrosine (pY) are partitioned into two conserved conformational clusters ( Blom, N.; Gammeltoft, S.; Brunak, S. J. Mol. Biol. 1999 , 294 , 1351 - 1362 ). We have used the spectral clustering algorithm to cluster the increasingly growing number of protein structures with pY sites, and have found that the pY residues cluster into three distinct side chain conformations. Two of these pY conformational clusters associate strongly with a narrow range of tyrosine backbone conformation. The novel cluster also highly correlates with the identity of the n + 1 residue, and is strongly associated with a sequential pYpY conformation which places two adjacent pY side chains in a specific relative orientation. Further analysis shows that the three pY clusters are associated with distinct distributions of cognate protein kinases.

  6. Renyi entropy and conformal defects

    Energy Technology Data Exchange (ETDEWEB)

    Bianchi, Lorenzo [Humboldt-Univ. Berlin (Germany). Inst. fuer Physik; Hamburg Univ. (Germany). II. Inst. fuer Theoretische Physik; Meineri, Marco [Scuola Normale Superiore, Pisa (Italy); Perimeter Institute for Theoretical Physics, Waterloo, ON (Canada); Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Myers, Robert C. [Perimeter Institute for Theoretical Physics, Waterloo, ON (Canada); Smolkin, Michael [California Univ., Berkely, CA (United States). Center for Theoretical Physics and Department of Physics

    2016-04-18

    We propose a field theoretic framework for calculating the dependence of Renyi entropies on the shape of the entangling surface in a conformal field theory. Our approach rests on regarding the corresponding twist operator as a conformal defect and in particular, we define the displacement operator which implements small local deformations of the entangling surface. We identify a simple constraint between the coefficient defining the two-point function of the displacement operator and the conformal weight of the twist operator, which consolidates a number of distinct conjectures on the shape dependence of the Renyi entropy. As an example, using this approach, we examine a conjecture regarding the universal coefficient associated with a conical singularity in the entangling surface for CFTs in any number of spacetime dimensions. We also provide a general formula for the second order variation of the Renyi entropy arising from small deformations of a spherical entangling surface, extending Mezei's results for the entanglement entropy.

  7. Conformal dimension theory and application

    CERN Document Server

    Mackay, John M

    2010-01-01

    Conformal dimension measures the extent to which the Hausdorff dimension of a metric space can be lowered by quasisymmetric deformations. Introduced by Pansu in 1989, this concept has proved extremely fruitful in a diverse range of areas, including geometric function theory, conformal dynamics, and geometric group theory. This survey leads the reader from the definitions and basic theory through to active research applications in geometric function theory, Gromov hyperbolic geometry, and the dynamics of rational maps, amongst other areas. It reviews the theory of dimension in metric spaces and of deformations of metric spaces. It summarizes the basic tools for estimating conformal dimension and illustrates their application to concrete problems of independent interest. Numerous examples and proofs are provided. Working from basic definitions through to current research areas, this book can be used as a guide for graduate students interested in this field, or as a helpful survey for experts. Background needed ...

  8. Elementary introduction to conformal invariance

    International Nuclear Information System (INIS)

    Grandati, Y.

    1992-01-01

    These notes constitute an elementary introduction to the concept of conformal invariance and its applications to the study of bidimensional critical phenomena. The aim is to give an access as pedestrian as possible to this vast subject. After a brief account of the general properties of conformal transformation in D dimensions, we study more specifically the case D = 2. The center of the discussion is then the consequences of the action of this symmetry group on bidimensional field theories, and in particular the links between the representations of the Virasoro algebra and the structure of the correlation functions of conformal field theories. Finally after showing how the Ising model reduces to a Majorana fermionic field theory, we see how the general formalism previously discussed can be applied to the Ising case at the critical point. (orig.)

  9. Conformal geometry and quasiregular mappings

    CERN Document Server

    Vuorinen, Matti

    1988-01-01

    This book is an introduction to the theory of spatial quasiregular mappings intended for the uninitiated reader. At the same time the book also addresses specialists in classical analysis and, in particular, geometric function theory. The text leads the reader to the frontier of current research and covers some most recent developments in the subject, previously scatterd through the literature. A major role in this monograph is played by certain conformal invariants which are solutions of extremal problems related to extremal lengths of curve families. These invariants are then applied to prove sharp distortion theorems for quasiregular mappings. One of these extremal problems of conformal geometry generalizes a classical two-dimensional problem of O. Teichmüller. The novel feature of the exposition is the way in which conformal invariants are applied and the sharp results obtained should be of considerable interest even in the two-dimensional particular case. This book combines the features of a textbook an...

  10. Renyi entropy and conformal defects

    International Nuclear Information System (INIS)

    Bianchi, Lorenzo; Myers, Robert C.; Smolkin, Michael

    2016-01-01

    We propose a field theoretic framework for calculating the dependence of Renyi entropies on the shape of the entangling surface in a conformal field theory. Our approach rests on regarding the corresponding twist operator as a conformal defect and in particular, we define the displacement operator which implements small local deformations of the entangling surface. We identify a simple constraint between the coefficient defining the two-point function of the displacement operator and the conformal weight of the twist operator, which consolidates a number of distinct conjectures on the shape dependence of the Renyi entropy. As an example, using this approach, we examine a conjecture regarding the universal coefficient associated with a conical singularity in the entangling surface for CFTs in any number of spacetime dimensions. We also provide a general formula for the second order variation of the Renyi entropy arising from small deformations of a spherical entangling surface, extending Mezei's results for the entanglement entropy.

  11. Structures of closed and open conformations of dimeric human ATM

    Science.gov (United States)

    Baretić, Domagoj; Pollard, Hannah K.; Fisher, David I.; Johnson, Christopher M.; Santhanam, Balaji; Truman, Caroline M.; Kouba, Tomas; Fersht, Alan R.; Phillips, Christopher; Williams, Roger L.

    2017-01-01

    ATM (ataxia-telangiectasia mutated) is a phosphatidylinositol 3-kinase–related protein kinase (PIKK) best known for its role in DNA damage response. ATM also functions in oxidative stress response, insulin signaling, and neurogenesis. Our electron cryomicroscopy (cryo-EM) suggests that human ATM is in a dynamic equilibrium between closed and open dimers. In the closed state, the PIKK regulatory domain blocks the peptide substrate–binding site, suggesting that this conformation may represent an inactive or basally active enzyme. The active site is held in this closed conformation by interaction with a long helical hairpin in the TRD3 (tetratricopeptide repeats domain 3) domain of the symmetry-related molecule. The open dimer has two protomers with only a limited contact interface, and it lacks the intermolecular interactions that block the peptide-binding site in the closed dimer. This suggests that the open conformation may be more active. The ATM structure shows the detailed topology of the regulator-interacting N-terminal helical solenoid. The ATM conformational dynamics shown by the structures represent an important step in understanding the enzyme regulation. PMID:28508083

  12. SUSY Unparticle and Conformal Sequestering

    Energy Technology Data Exchange (ETDEWEB)

    Nakayama, Yu; Nakayama, Yu

    2007-07-17

    We investigate unparticle physics with supersymmetry (SUSY). The SUSY breaking effects due to the gravity mediation induce soft masses for the SUSY unparticles and hence break the conformal invariance. The unparticle physics observable in near future experiments is only consistent if the SUSY breakingeffects from the hidden sector to the standard model sector are dominated by the gauge mediation, or if the SUSY breaking effects to the unparticle sector are sufficiently sequestered. We argue that the natural realization of the latter possibility is the conformal sequestering scenario.

  13. Epigenetic dominance of prion conformers.

    Directory of Open Access Journals (Sweden)

    Eri Saijo

    2013-10-01

    Full Text Available Although they share certain biological properties with nucleic acid based infectious agents, prions, the causative agents of invariably fatal, transmissible neurodegenerative disorders such as bovine spongiform encephalopathy, sheep scrapie, and human Creutzfeldt Jakob disease, propagate by conformational templating of host encoded proteins. Once thought to be unique to these diseases, this mechanism is now recognized as a ubiquitous means of information transfer in biological systems, including other protein misfolding disorders such as those causing Alzheimer's and Parkinson's diseases. To address the poorly understood mechanism by which host prion protein (PrP primary structures interact with distinct prion conformations to influence pathogenesis, we produced transgenic (Tg mice expressing different sheep scrapie susceptibility alleles, varying only at a single amino acid at PrP residue 136. Tg mice expressing ovine PrP with alanine (A at (OvPrP-A136 infected with SSBP/1 scrapie prions propagated a relatively stable (S prion conformation, which accumulated as punctate aggregates in the brain, and produced prolonged incubation times. In contrast, Tg mice expressing OvPrP with valine (V at 136 (OvPrP-V136 infected with the same prions developed disease rapidly, and the converted prion was comprised of an unstable (U, diffusely distributed conformer. Infected Tg mice co-expressing both alleles manifested properties consistent with the U conformer, suggesting a dominant effect resulting from exclusive conversion of OvPrP-V136 but not OvPrP-A136. Surprisingly, however, studies with monoclonal antibody (mAb PRC5, which discriminates OvPrP-A136 from OvPrP-V136, revealed substantial conversion of OvPrP-A136. Moreover, the resulting OvPrP-A136 prion acquired the characteristics of the U conformer. These results, substantiated by in vitro analyses, indicated that co-expression of OvPrP-V136 altered the conversion potential of OvPrP-A136 from the S to

  14. Topics in conformal field theory

    International Nuclear Information System (INIS)

    Kiritsis, E.B.

    1988-01-01

    In this work two major topics in Conformal Field Theory are discussed. First a detailed investigation of N = 2 Superconformal theories is presented. The structure of the representations of the N = 2 superconformal algebras is investigated and the character formulae are calculated. The general structure of N = 2 superconformal theories is elucidated and the operator algebra of the minimal models is derived. The first minimal system is discussed in more detail. Second, applications of the conformal techniques are studied in the Ashkin-Teller model. The c = 1 as well as the c = 1/2 critical lines are discussed in detail

  15. Spin-4 extended conformal algebras

    International Nuclear Information System (INIS)

    Kakas, A.C.

    1988-01-01

    We construct spin-4 extended conformal algebras using the second hamiltonian structure of the KdV hierarchy. In the presence of a U(1) current a family of spin-4 algebras exists but the additional requirement that the spin-1 and spin-4 currents commute fixes the algebra uniquely. (orig.)

  16. Defects in conformal field theory

    International Nuclear Information System (INIS)

    Billò, Marco; Gonçalves, Vasco; Lauria, Edoardo; Meineri, Marco

    2016-01-01

    We discuss consequences of the breaking of conformal symmetry by a flat or spherical extended operator. We adapt the embedding formalism to the study of correlation functions of symmetric traceless tensors in the presence of the defect. Two-point functions of a bulk and a defect primary are fixed by conformal invariance up to a set of OPE coefficients, and we identify the allowed tensor structures. A correlator of two bulk primaries depends on two cross-ratios, and we study its conformal block decomposition in the case of external scalars. The Casimir equation in the defect channel reduces to a hypergeometric equation, while the bulk channel blocks are recursively determined in the light-cone limit. In the special case of a defect of codimension two, we map the Casimir equation in the bulk channel to the one of a four-point function without defect. Finally, we analyze the contact terms of the stress-tensor with the extended operator, and we deduce constraints on the CFT data. In two dimensions, we relate the displacement operator, which appears among the contact terms, to the reflection coefficient of a conformal interface, and we find unitarity bounds for the latter.

  17. Conformal symmetry and holographic cosmology

    NARCIS (Netherlands)

    Bzowski, A.W.

    2013-01-01

    This thesis presents a novel approach to cosmology using gauge/gravity duality. Analysis of the implications of conformal invariance in field theories leads to quantitative cosmological predictions which are in agreement with current data. Furthermore, holographic cosmology extends the theory of

  18. Checking behavioral conformance of artifacts

    NARCIS (Netherlands)

    Fahland, D.; Leoni, de M.; Dongen, van B.F.; Aalst, van der W.M.P.

    2011-01-01

    The usefulness of process models (e.g., for analysis, improvement, or execution) strongly depends on their ability to describe reality. Conformance checking is a technique to validate how good a given process model describes recorded executions of the actual process. Recently, artifacts have been

  19. Conformation analysis of oligomeric flavanoids

    Science.gov (United States)

    Jan P. Steynberg; E. Vincent Brandt; Daneel Ferreira; Carin A. Helfer; Wayne L. Mattice; Dominika Gornik; Richard W. Hemingway

    1995-01-01

    The profisetinidins are the most important polyflavanoids of commerce, making up the major constituents of wattle and quebracho tannins. Within the dimeric profisetinidins, substantial complexity exists because of stereo-, regio, rotational and conformational isomers. Definition of the stereochemistry of the upper and lower flavan units, the location of the...

  20. Conformational analysis of oligomeric flavanoids

    Science.gov (United States)

    Jan P. Steynberg; E. Vincent Brandt; Daneel Ferreira; Carin A. Helfer; Wayne L. Mattice; Dominika Gornik; Richard W. Hemingway

    1995-01-01

    The profisetinidins are the most important polyflavanoids of commerce, making up the major constituents of wattle and quebracho tannins. Even within the dimeric profisetinidins, substantial complexity exists because of stereo-, regio-, rotational and conformational isomers. Definition of the stereochemistry of the upper and lower flavan units, the location of the...

  1. Inversion theory and conformal mapping

    CERN Document Server

    Blair, David E

    2000-01-01

    It is rarely taught in an undergraduate or even graduate curriculum that the only conformal maps in Euclidean space of dimension greater than two are those generated by similarities and inversions in spheres. This is in stark contrast to the wealth of conformal maps in the plane. The principal aim of this text is to give a treatment of this paucity of conformal maps in higher dimensions. The exposition includes both an analytic proof in general dimension and a differential-geometric proof in dimension three. For completeness, enough complex analysis is developed to prove the abundance of conformal maps in the plane. In addition, the book develops inversion theory as a subject, along with the auxiliary theme of circle-preserving maps. A particular feature is the inclusion of a paper by Carath�odory with the remarkable result that any circle-preserving transformation is necessarily a M�bius transformation, not even the continuity of the transformation is assumed. The text is at the level of advanced undergr...

  2. Defects in conformal field theory

    Energy Technology Data Exchange (ETDEWEB)

    Billò, Marco [Dipartimento di Fisica, Università di Torino, and Istituto Nazionale di Fisica Nucleare - sezione di Torino,Via P. Giuria 1 I-10125 Torino (Italy); Gonçalves, Vasco [Centro de Física do Porto,Departamento de Física e Astronomia Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto (Portugal); ICTP South American Institute for Fundamental Research Instituto de Física Teórica,UNESP - University Estadual Paulista,Rua Dr. Bento T. Ferraz 271, 01140-070, São Paulo, SP (Brazil); Lauria, Edoardo [Institute for Theoretical Physics, KU Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Meineri, Marco [Perimeter Institute for Theoretical Physics,Waterloo, Ontario, N2L 2Y5 (Canada); Scuola Normale Superiore, and Istituto Nazionale di Fisica Nucleare - sezione di Pisa,Piazza dei Cavalieri 7 I-56126 Pisa (Italy)

    2016-04-15

    We discuss consequences of the breaking of conformal symmetry by a flat or spherical extended operator. We adapt the embedding formalism to the study of correlation functions of symmetric traceless tensors in the presence of the defect. Two-point functions of a bulk and a defect primary are fixed by conformal invariance up to a set of OPE coefficients, and we identify the allowed tensor structures. A correlator of two bulk primaries depends on two cross-ratios, and we study its conformal block decomposition in the case of external scalars. The Casimir equation in the defect channel reduces to a hypergeometric equation, while the bulk channel blocks are recursively determined in the light-cone limit. In the special case of a defect of codimension two, we map the Casimir equation in the bulk channel to the one of a four-point function without defect. Finally, we analyze the contact terms of the stress-tensor with the extended operator, and we deduce constraints on the CFT data. In two dimensions, we relate the displacement operator, which appears among the contact terms, to the reflection coefficient of a conformal interface, and we find unitarity bounds for the latter.

  3. Supertwistor connection and conformal supergravity

    International Nuclear Information System (INIS)

    Merkulov, S.A.

    1985-01-01

    Supersymmetry expansion of the geometry of local twistors is suggested. Definition of the space of local supertwistors is given and its differential geometry is formulated. Variational principles are discussed, and it is shown that corresponding Euler-Lagrange equations also coincide and result in superzero equations of N=1 conformal supergravitation, which generalize Bach equations

  4. Conformal symmetry and string theories

    International Nuclear Information System (INIS)

    Kumar, A.

    1987-01-01

    This thesis is devoted to the study of various aspects of the 2-dimensional conformal field theory and its applications to strings. We make a short review of the conformal field theory and its supersymmetric extension, called superconformal field theory. We present an elegant superspace formulation of these theories and solve the condition for the closure of the superconformal algebra. The we go on to classify the superconformal field theories according to these solutions. We prove that N ≥ 5 superconformal algebra, with N being the number of supersymmetries, does not have central charge. We find the primary representations of all the interesting superconformal algebra. We study the quantization of the superconformal theories and derive the constraints on the central charge of the algebra that has to be satisfied for a consistent quantum theory. This quantization process also determines the ground state energy of the system and the spectrum of the model. We study the global aspects of the conformal symmetry and its role in the construction of consistent heterotic string theories. We prove the uniqueness of heterotic superstring theories in 10 dimensions in the fermionic constructions. We show how the vertex operators are closely associated with the primary field representation of the conformal algebra. We utilize these vertex operator constructions to obtain tree amplitudes in the 10-dimensional heterotic string theory. We show by explicit calculation at the 3-point level that the scattering amplitudes derived from the heterotic superstring are same as the ones obtained from 10-dimensional supergravity theories

  5. Exceptional and Spinorial Conformal Windows

    DEFF Research Database (Denmark)

    Mojaza, Matin; Pica, Claudio; Ryttov, Thomas

    2012-01-01

    We study the conformal window of gauge theories containing fermionic matter fields, where the gauge group is any of the exceptional groups with the fermions transforming according to the fundamental and adjoint representations and the orthogonal groups where the fermions transform according...

  6. Anomalous Dimensions of Conformal Baryons

    DEFF Research Database (Denmark)

    Pica, Claudio; Sannino, Francesco

    2016-01-01

    We determine the anomalous dimensions of baryon operators for the three color theory as function of the number of massless flavours within the conformal window to the maximum known order in perturbation theory. We show that the anomalous dimension of the baryon is controllably small, within...

  7. Conformal and Nearly Conformal Theories at Large N

    Science.gov (United States)

    Tarnoplskiy, Grigory M.

    In this thesis we present new results in conformal and nearly conformal field theories in various dimensions. In chapter two, we study different properties of the conformal Quantum Electrodynamics (QED) in continuous dimension d. At first we study conformal QED using large Nf methods, where Nf is the number of massless fermions. We compute its sphere free energy as a function of d, ignoring the terms of order 1/Nf and higher. For finite Nf we use the epsilon-expansion. Next we use a large Nf diagrammatic approach to calculate the leading corrections to CT, the coefficient of the two-point function of the stress-energy tensor, and CJ, the coefficient of the two-point function of the global symmetry current. We present explicit formulae as a function of d and check them versus the expectations in 2 and 4 - epsilon dimensions. In chapter three, we discuss vacuum stability in 1 + 1 dimensional conformal field theories with external background fields. We show that the vacuum decay rate is given by a non-local two-form. This two-form is a boundary term that must be added to the effective in/out Lagrangian. The two-form is expressed in terms of a Riemann-Hilbert decomposition for background gauge fields, and is given by its novel "functional'' version in the gravitational case. In chapter four, we explore Tensor models. Such models possess the large N limit dominated by the melon diagrams. The quantum mechanics of a real anti-commuting rank-3 tensor has a large N limit similar to the Sachdev-Ye-Kitaev (SYK) model. We also discuss the quantum mechanics of a complex 3-index anti-commuting tensor and argue that it is equivalent in the large N limit to a version of SYK model with complex fermions. Finally, we discuss models of a commuting tensor in dimension d. We study the spectrum of the large N quantum field theory of bosonic rank-3 tensors using the Schwinger-Dyson equations. We compare some of these results with the 4 - epsilon expansion, finding perfect agreement. We

  8. Conformal invariance in the quantum field theory

    International Nuclear Information System (INIS)

    Kurak, V.

    1975-09-01

    Basic features concerning the present knowledge of conformal symmetry are illustrated in a simple model. Composite field dimensions of this model are computed and related to the conformal group. (author) [pt

  9. O perfil Brasileiro de propriedade intelectual em radiologia e diagnóstico por imagem em um contexto internacional, nos anos 2000-2009

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Barbosa Serapião

    2011-08-01

    Full Text Available OBJETIVO: Analisar a inovação tecnológica brasileira na área de radiologia e diagnóstico por imagem, em termos de indicadores de patentes. MATERIAIS E MÉTODOS: Este é um estudo analítico-exploratório de informações recuperadas por meio de consultas cruzadas nas bases de dados dos escritórios de propriedade intelectual do Brasil (Instituto Nacional da Propriedade Industrial - INPI, dos Estados Unidos (United States Patent and Trademark Office - USPTO e da Europa (European Patent Office - EPO. RESULTADOS: Foram encontradas 277.057 patentes. Desse total, 7.800 foram registradas no INPI (3%, 65.428 (24% registradas no EPO e 203.829 (73% emitidas no USPTO. O Brasil é o país signatário em 1.732 patentes publicadas no INPI, 80 no EPO e 26 no escritório USPTO. Globalmente, 219.993 (79% patentes referiam-se a dispositivos eletrônicos ligados a informática em saúde, ultrassonografia, ressonância magnética, tomografia computadorizada e procedimentos de geração, comunicação e arquivamento de imagens, e 57.064 (21% das patentes tratavam das tecnologias relacionadas a radioproteção e dosimetria, física nuclear, eletroterapia, terapia magnética e radioterapia. CONCLUSÃO: Os resultados obtidos apontam para a fragilidade da produção nacional de inovação tecnológica registrada em patentes, no campo de radiologia e diagnóstico por Imagem.

  10. The Conformational Behaviour of Glucosamine

    Science.gov (United States)

    Peña, Isabel; Kolesniková, Lucie; Cabezas, Carlos; Bermúdez, Celina; Berdakin, Matías; Simao, Alcides; Alonso, José L.

    2014-06-01

    A laser ablation method has been successfully used to vaporize the bioactive amino monosaccharide D-glucosamine. Three cyclic α-4C1 pyranose forms have been identified using a combination of CP-FTMW and LA-MB-FTMW spectroscopy. Stereoelectronic hyperconjugative factors, like those associated with anomeric or gauche effects, as well as the cooperative OH\\cdotsO, OH\\cdotsN and NH\\cdotsO chains, extended along the entire molecule, are the main factors driving the conformational behavior. All observed conformers exhibit a counter-clockwise arrangement (cc) of the network of intramolecular hydrogen bonds. The results are compared with those recently obtained for D-glucose. J. L. Alonso, M. A. Lozoya, I. Peña, J. C. López, C. Cabezas, S. Mata, S. Blanco, Chem. Sci. 2014, 5, 515.

  11. Conformal invariance from nonconformal gravity

    International Nuclear Information System (INIS)

    Meissner, Krzysztof A.; Nicolai, Hermann

    2009-01-01

    We discuss the conditions under which classically conformally invariant models in four dimensions can arise out of nonconformal (Einstein) gravity. As an 'existence proof' that this is indeed possible we show how to derive N=4 super Yang-Mills theory with any compact gauge group G from nonconformal gauged N=4 supergravity as a special flat space limit. We stress the role that the anticipated UV finiteness of the (so far unknown) underlying theory of quantum gravity would have to play in such a scheme, as well as the fact that the masses of elementary particles would have to arise via quantum gravitational effects which mimic the conformal anomalies of standard (flat space) UV divergent quantum field theory.

  12. Conformal methods in general relativity

    CERN Document Server

    Valiente Kroon, Juan A

    2016-01-01

    This book offers a systematic exposition of conformal methods and how they can be used to study the global properties of solutions to the equations of Einstein's theory of gravity. It shows that combining these ideas with differential geometry can elucidate the existence and stability of the basic solutions of the theory. Introducing the differential geometric, spinorial and PDE background required to gain a deep understanding of conformal methods, this text provides an accessible account of key results in mathematical relativity over the last thirty years, including the stability of de Sitter and Minkowski spacetimes. For graduate students and researchers, this self-contained account includes useful visual models to help the reader grasp abstract concepts and a list of further reading, making this the perfect reference companion on the topic.

  13. Gel dosimetry for conformal radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Gambarini, G [Department of Physics of the University and INFN, Milan (Italy)

    2005-07-01

    With the continuum development of conformal radio therapies, aimed at delivering high dose to tumor tissue and low dose to the healthy tissue around, the necessities has appeared of suitable improvement of dosimetry techniques giving the possibility of obtaining dose images to be compared with diagnostic images. Also if wide software has been developed for calculating dose distributions in the fields of various radiotherapy units, experimental verifications are necessary, in particular in the case of complex geometries in conformal radiotherapy. Gel dosimetry is a promising method for imaging the absorbed dose in tissue-equivalent phantoms, with the possibility of 3D reconstruction of the spatial dose distribution, with milli metric resolution. Optical imaging of gel dosimeters, based on visible light absorbance analysis, has shown to be a reliable technique for achieving dose distributions. (Author)

  14. Conformal FDTD modeling wake fields

    Energy Technology Data Exchange (ETDEWEB)

    Jurgens, T.; Harfoush, F.

    1991-05-01

    Many computer codes have been written to model wake fields. Here we describe the use of the Conformal Finite Difference Time Domain (CFDTD) method to model the wake fields generated by a rigid beam traveling through various accelerating structures. The non- cylindrical symmetry of some of the problems considered here requires the use of a three dimensional code. In traditional FDTD codes, curved surfaces are approximated by rectangular steps. The errors introduced in wake field calculations by such an approximation can be reduced by increasing the mesh size, therefore increasing the cost of computing. Another approach, validated here, deforms Ampere and Faraday contours near a media interface so as to conform to the interface. These improvements of the FDTD method result in better accuracy of the fields at asymptotically no computational cost. This method is also capable of modeling thin wires as found in beam profile monitors, and slots and cracks as found in resistive wall motions. 4 refs., 5 figs.

  15. Conformal manifolds: ODEs from OPEs

    Science.gov (United States)

    Behan, Connor

    2018-03-01

    The existence of an exactly marginal deformation in a conformal field theory is very special, but it is not well understood how this is reflected in the allowed dimensions and OPE coefficients of local operators. To shed light on this question, we compute perturbative corrections to several observables in an abstract CFT, starting with the beta function. This yields a sum rule that the theory must obey in order to be part of a conformal manifold. The set of constraints relating CFT data at different values of the coupling can in principle be written as a dynamical system that allows one to flow arbitrarily far. We begin the analysis of it by finding a simple form for the differential equations when the spacetime and theory space are both one-dimensional. A useful feature we can immediately observe is that our system makes it very difficult for level crossing to occur.

  16. Conformal field theories and critical phenomena

    International Nuclear Information System (INIS)

    Xu, Bowei

    1993-01-01

    In this article we present a brief review of the conformal symmetry and the two dimensional conformal quantum field theories. As concrete applications of the conformal theories to the critical phenomena in statistical systems, we calculate the value of central charge and the anomalous scale dimensions of the Z 2 symmetric quantum chain with boundary condition. The results are compatible with the prediction of the conformal field theories

  17. Conformal group actions and Segal's cosmology

    International Nuclear Information System (INIS)

    Werth, J.-E.

    1984-01-01

    A mathematical description of Segal's cosmological model in the framework of conformal group actions is presented. The relation between conformal and causal group actions on time-orientable Lorentzian manifolds is analysed and several examples are discussed. A criterion for the conformality of a map between Lorentzian manifolds is given. The results are applied to Segal's 'conformal compactification' of Minkowski space. Furthermore, the 'unitary formulation' of Segal's cosmology is regarded. (Author) [pt

  18. Generative Models of Conformational Dynamics

    OpenAIRE

    Langmead, Christopher James

    2014-01-01

    Atomistic simulations of the conformational dynamics of proteins can be performed using either Molecular Dynamics or Monte Carlo procedures. The ensembles of three-dimensional structures produced during simulation can be analyzed in a number of ways to elucidate the thermodynamic and kinetic properties of the system. The goal of this chapter is to review both traditional and emerging methods for learning generative models from atomistic simulation data. Here, the term ‘generative’ refers to a...

  19. Holographic multiverse and conformal invariance

    Energy Technology Data Exchange (ETDEWEB)

    Garriga, Jaume [Departament de Física Fonamental i Institut de Ciències del Cosmos, Universitat de Barcelona, Martí i Franquès 1, 08193 Barcelona (Spain); Vilenkin, Alexander, E-mail: jaume.garriga@ub.edu, E-mail: vilenkin@cosmos.phy.tufts.edu [Institute of Cosmology, Department of Physics and Astronomy, Tufts University, 212 College Ave., Medford, MA 02155 (United States)

    2009-11-01

    We consider a holographic description of the inflationary multiverse, according to which the wave function of the universe is interpreted as the generating functional for a lower dimensional Euclidean theory. We analyze a simple model where transitions between inflationary vacua occur through bubble nucleation, and the inflating part of spacetime consists of de Sitter regions separated by thin bubble walls. In this model, we present some evidence that the dual theory is conformally invariant in the UV.

  20. Holographic multiverse and conformal invariance

    International Nuclear Information System (INIS)

    Garriga, Jaume; Vilenkin, Alexander

    2009-01-01

    We consider a holographic description of the inflationary multiverse, according to which the wave function of the universe is interpreted as the generating functional for a lower dimensional Euclidean theory. We analyze a simple model where transitions between inflationary vacua occur through bubble nucleation, and the inflating part of spacetime consists of de Sitter regions separated by thin bubble walls. In this model, we present some evidence that the dual theory is conformally invariant in the UV

  1. Integrability of conformal fishnet theory

    Science.gov (United States)

    Gromov, Nikolay; Kazakov, Vladimir; Korchemsky, Gregory; Negro, Stefano; Sizov, Grigory

    2018-01-01

    We study integrability of fishnet-type Feynman graphs arising in planar four-dimensional bi-scalar chiral theory recently proposed in arXiv:1512.06704 as a special double scaling limit of gamma-deformed N = 4 SYM theory. We show that the transfer matrix "building" the fishnet graphs emerges from the R-matrix of non-compact conformal SU(2 , 2) Heisenberg spin chain with spins belonging to principal series representations of the four-dimensional conformal group. We demonstrate explicitly a relationship between this integrable spin chain and the Quantum Spectral Curve (QSC) of N = 4 SYM. Using QSC and spin chain methods, we construct Baxter equation for Q-functions of the conformal spin chain needed for computation of the anomalous dimensions of operators of the type tr( ϕ 1 J ) where ϕ 1 is one of the two scalars of the theory. For J = 3 we derive from QSC a quantization condition that fixes the relevant solution of Baxter equation. The scaling dimensions of the operators only receive contributions from wheel-like graphs. We develop integrability techniques to compute the divergent part of these graphs and use it to present the weak coupling expansion of dimensions to very high orders. Then we apply our exact equations to calculate the anomalous dimensions with J = 3 to practically unlimited precision at any coupling. These equations also describe an infinite tower of local conformal operators all carrying the same charge J = 3. The method should be applicable for any J and, in principle, to any local operators of bi-scalar theory. We show that at strong coupling the scaling dimensions can be derived from semiclassical quantization of finite gap solutions describing an integrable system of noncompact SU(2 , 2) spins. This bears similarities with the classical strings arising in the strongly coupled limit of N = 4 SYM.

  2. Objective interpretation as conforming interpretation

    Directory of Open Access Journals (Sweden)

    Lidka Rodak

    2011-12-01

    Full Text Available The practical discourse willingly uses the formula of “objective interpretation”, with no regards to its controversial nature that has been discussed in literature.The main aim of the article is to investigate what “objective interpretation” could mean and how it could be understood in the practical discourse, focusing on the understanding offered by judicature.The thesis of the article is that objective interpretation, as identified with textualists’ position, is not possible to uphold, and should be rather linked with conforming interpretation. And what this actually implies is that it is not the virtue of certainty and predictability – which are usually associated with objectivity- but coherence that makes the foundation of applicability of objectivity in law.What could be observed from the analyses, is that both the phenomenon of conforming interpretation and objective interpretation play the role of arguments in the interpretive discourse, arguments that provide justification that interpretation is not arbitrary or subjective. With regards to the important part of the ideology of legal application which is the conviction that decisions should be taken on the basis of law in order to exclude arbitrariness, objective interpretation could be read as a question “what kind of authority “supports” certain interpretation”? that is almost never free of judicial creativity and judicial activism.One can say that, objective and conforming interpretation are just another arguments used in legal discourse.

  3. Conformational kinetics of aliphatic tails

    Science.gov (United States)

    Ferrarini, Alberta; Moro, Giorgio; Nordio, Pier Luigi

    The master equation describing the random walk between sites identified with the stable conformers of a chain molecule, represents the extension to the time domain of the Rotational Isomeric State model. The asymptotic analysis of the multidimensional diffusion equation in the continuous torsional variables subjected to the configurational potential, provides a rigorous justification for the discrete models, and it supplies, without resorting to phenomenological parameters, molecular definitions of the kinetic rates for the conformational transitions occurring at each segment of the chain. The coupling between the torsional variables is fully taken into account, giving rise to cooperative effects. A complete calculation of the specific correlation functions which describe the time evolution of the angular functions probed by N.M.R. and dielectric relaxation measurements, has been performed for alkyl chains attached to a massive core. The resulting behaviour has been compared with the decay of trans and gauche populations of specific bonds, expressed in terms of suitable correlation functions whose time integrals lead quite naturally to the definition of effective kinetic constants for the conformational transitions.

  4. Anomalies, conformal manifolds, and spheres

    Energy Technology Data Exchange (ETDEWEB)

    Gomis, Jaume [Perimeter Institute for Theoretical Physics,Waterloo, Ontario, N2L 2Y5 (Canada); Hsin, Po-Shen [Department of Physics, Princeton University,Princeton, NJ 08544 (United States); Komargodski, Zohar; Schwimmer, Adam [Weizmann Institute of Science,Rehovot 76100 (Israel); Seiberg, Nathan [School of Natural Sciences, Institute for Advanced Study,Princeton, NJ 08540 (United States); Theisen, Stefan [Max-Planck-Institut für Gravitationsphysik, Albert-Einstein-Institut,14476 Golm (Germany)

    2016-03-04

    The two-point function of exactly marginal operators leads to a universal contribution to the trace anomaly in even dimensions. We study aspects of this trace anomaly, emphasizing its interpretation as a sigma model, whose target space M is the space of conformal field theories (a.k.a. the conformal manifold). When the underlying quantum field theory is supersymmetric, this sigma model has to be appropriately supersymmetrized. As examples, we consider in some detail N=(2,2) and N=(0,2) supersymmetric theories in d=2 and N=2 supersymmetric theories in d=4. This reasoning leads to new information about the conformal manifolds of these theories, for example, we show that the manifold is Kähler-Hodge and we further argue that it has vanishing Kähler class. For N=(2,2) theories in d=2 and N=2 theories in d=4 we also show that the relation between the sphere partition function and the Kähler potential of M follows immediately from the appropriate sigma models that we construct. Along the way we find several examples of potential trace anomalies that obey the Wess-Zumino consistency conditions, but can be ruled out by a more detailed analysis.

  5. Electrophysiological precursors of social conformity

    Science.gov (United States)

    Rieskamp, Jörg; Tugin, Sergey; Ossadtchi, Alexey; Krutitskaya, Janina; Klucharev, Vasily

    2013-01-01

    Humans often change their beliefs or behavior due to the behavior or opinions of others. This study explored, with the use of human event-related potentials (ERPs), whether social conformity is based on a general performance-monitoring mechanism. We tested the hypothesis that conflicts with a normative group opinion evoke a feedback-related negativity (FRN) often associated with performance monitoring and subsequent adjustment of behavior. The experimental results show that individual judgments of facial attractiveness were adjusted in line with a normative group opinion. A mismatch between individual and group opinions triggered a frontocentral negative deflection with the maximum at 200 ms, similar to FRN. Overall, a conflict with a normative group opinion triggered a cascade of neuronal responses: from an earlier FRN response reflecting a conflict with the normative opinion to a later ERP component (peaking at 380 ms) reflecting a conforming behavioral adjustment. These results add to the growing literature on neuronal mechanisms of social influence by disentangling the conflict-monitoring signal in response to the perceived violation of social norms and the neural signal of a conforming behavioral adjustment. PMID:22683703

  6. CONFORMITY IN CHRIST 1. THE TRANSFORMATION PROCESS

    African Journals Online (AJOL)

    This essay investigates the notion of conformity in Christ as it is part of a compre- hensive, multilayered process of transformation. In the first part it focuses on the process of transformation in creation, re-creation, conformity, love and glory. In the second part it discusses transformation in Christ by looking at conformation and ...

  7. 40 CFR 52.938 - General conformity.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false General conformity. 52.938 Section 52...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Kentucky § 52.938 General conformity. The General Conformity regulations were submitted on November 10, 1995, and adopted into the Kentucky State...

  8. 40 CFR 51.854 - Conformity analysis.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Conformity analysis. 51.854 Section 51... FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Determining Conformity of General Federal Actions to State or Federal Implementation Plans § 51.854 Conformity analysis. Link to an...

  9. 40 CFR 52.2133 - General conformity.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 4 2010-07-01 2010-07-01 false General conformity. 52.2133 Section 52...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) South Carolina § 52.2133 General conformity. The General Conformity regulations adopted into the South Carolina State Implementation Plan which...

  10. Conformity in Christ | Waaijman | Acta Theologica

    African Journals Online (AJOL)

    This essay investigates the notion of conformity in Christ as it is part of a comprehensive, multilayered process of transformation. In the first part it focuses on the process of transformation in creation, re-creation, conformity, love and glory. In the second part it discusses transformation in Christ by looking at conformation and ...

  11. Prevenção e controle das seqüelas bucais em pacientes irradiados por tumores de cabeça e pescoço Prevention and control of sequels in the mouth of patients treated with radiation therapy for head and neck tumors

    Directory of Open Access Journals (Sweden)

    Maria de Fátima Aparecida Cardoso

    2005-04-01

    Full Text Available A cirurgia e a radioterapia são os principais métodos de tratamento das neoplasias de cabeça e pescoço. Dentre os efeitos colaterais resultantes da interação da radiação ionizante sobre os tecidos, temos dermatite, mucosite, xerostomia, candidíase, alteração do paladar, disfagia, cárie, trismo e osteorradionecrose. OBJETIVO: Avaliar a condição odontológica dos pacientes, através de protocolo que permita impedir ou minimizar os efeitos da radiação sobre os tecidos da cavidade bucal. MATERIAIS E MÉTODOS: Realizou-se acompanhamento odontológico, antes, durante e até 180 dias após a radioterapia, em 12 pacientes submetidos a cirurgia e radioterapia, ou radioterapia exclusiva. RESULTADOS: Efeitos como dermatite, mucosite, alteração do paladar e disfagia cresceram em proporção a partir da segunda semana de tratamento até o final das aplicações, decrescendo visivelmente quando do término, chegando próximos aos valores basais após 180 dias. Quanto à xerostomia, a redução ocorreu mais lentamente e com menor efetividade. Cárie, trismo e osteorradionecrose não foram observados durante o período de avaliação. CONCLUSÃO: O acompanhamento odontológico sistemático, junto com medidas preventivas como adequação bucal prévia, orientações sobre higienização, utilização de bochechos de água bicarbonatada, chá de camomila, aplicação tópica de flúor, contribuíram para promover melhores condições de restabelecimento em pacientes com neoplasia da região de cabeça e pescoço submetidos à radioterapia.Surgery and radiation therapy are de main treatments for head and neck cancer. The side effects of the interaction of ionizing radiation on the tissues include dermatitis, mucositis, xerostomia, candidiasis, dysgeusia, dysphagia, caries, trismus, osteoradionecrosis. OBJECTIVE: To assess dental condition of the patients using a protocol which allows avoiding or reducing the effects of radiation in the tissues of

  12. Conformal symmetry inheritance in null fluid spacetimes

    International Nuclear Information System (INIS)

    Tupper, B O J; Keane, A J; Hall, G S; Coley, A A; Carot, J

    2003-01-01

    We define inheriting conformal Killing vectors for null fluid spacetimes and find the maximum dimension of the associated inheriting Lie algebra. We show that for non-conformally flat null fluid spacetimes, the maximum dimension of the inheriting algebra is seven and for conformally flat null fluid spacetimes the maximum dimension is eight. In addition, it is shown that there are two distinct classes of non-conformally flat generalized plane wave spacetimes which possess the maximum dimension, and one class in the conformally flat case

  13. Families and degenerations of conformal field theories

    Energy Technology Data Exchange (ETDEWEB)

    Roggenkamp, D.

    2004-09-01

    In this work, moduli spaces of conformal field theories are investigated. In the first part, moduli spaces corresponding to current-current deformation of conformal field theories are constructed explicitly. For WZW models, they are described in detail, and sigma model realizations of the deformed WZW models are presented. The second part is devoted to the study of boundaries of moduli spaces of conformal field theories. For this purpose a notion of convergence of families of conformal field theories is introduced, which admits certain degenerated conformal field theories to occur as limits. To such a degeneration of conformal field theories, a degeneration of metric spaces together with additional geometric structures can be associated, which give rise to a geometric interpretation. Boundaries of moduli spaces of toroidal conformal field theories, orbifolds thereof and WZW models are analyzed. Furthermore, also the limit of the discrete family of Virasoro minimal models is investigated. (orig.)

  14. Significado prognóstico do linfonodo metastático N3 em carcinomas epidermóides de cabeça e pescoço

    OpenAIRE

    Amar,Ali; Curioni,Otávio Alberto; Rapoport,Abrão

    2004-01-01

    OBJETIVO: Avaliar os resultados do tratamento da doença metastática em estádio avançado (N3) e sua relação com o prognóstico do carcinoma espinocelular de cabeça e pescoço. MÉTODO: Foram revisados as informações de prontuários de 241 pacientes, com carcinoma espinocelular de boca, orofaringe, laringe e hipofaringe com metástases cervicais maiores que 6 cm (N3) submetidos à cirurgia e/ou radioterapia, no Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia do Hospital Heliópolis...

  15. The Biological Bases of Conformity

    Science.gov (United States)

    Morgan, T. J. H.; Laland, K. N.

    2012-01-01

    Humans are characterized by an extreme dependence on culturally transmitted information and recent formal theory predicts that natural selection should favor adaptive learning strategies that facilitate effective copying and decision making. One strategy that has attracted particular attention is conformist transmission, defined as the disproportionately likely adoption of the most common variant. Conformity has historically been emphasized as significant in the social psychology literature, and recently there have also been reports of conformist behavior in non-human animals. However, mathematical analyses differ in how important and widespread they expect conformity to be, and relevant experimental work is scarce, and generates findings that are both mutually contradictory and inconsistent with the predictions of the models. We review the relevant literature considering the causation, function, history, and ontogeny of conformity, and describe a computer-based experiment on human subjects that we carried out in order to resolve ambiguities. We found that only when many demonstrators were available and subjects were uncertain was subject behavior conformist. A further analysis found that the underlying response to social information alone was generally conformist. Thus, our data are consistent with a conformist use of social information, but as subjects’ behavior is the result of both social and asocial influences, the resultant behavior may not be conformist. We end by relating these findings to an embryonic cognitive neuroscience literature that has recently begun to explore the neural bases of social learning. Here conformist transmission may be a particularly useful case study, not only because there are well-defined and tractable opportunities to characterize the biological underpinnings of this form of social learning, but also because early findings imply that humans may possess specific cognitive adaptations for effective social learning. PMID:22712006

  16. Conformance Testing: Measurement Decision Rules

    Science.gov (United States)

    Mimbs, Scott M.

    2010-01-01

    The goal of a Quality Management System (QMS) as specified in ISO 9001 and AS9100 is to provide assurance to the customer that end products meet specifications. Measuring devices, often called measuring and test equipment (MTE), are used to provide the evidence of product conformity to specified requirements. Unfortunately, processes that employ MTE can become a weak link to the overall QMS if proper attention is not given to the measurement process design, capability, and implementation. Documented "decision rules" establish the requirements to ensure measurement processes provide the measurement data that supports the needs of the QMS. Measurement data are used to make the decisions that impact all areas of technology. Whether measurements support research, design, production, or maintenance, ensuring the data supports the decision is crucial. Measurement data quality can be critical to the resulting consequences of measurement-based decisions. Historically, most industries required simplistic, one-size-fits-all decision rules for measurements. One-size-fits-all rules in some cases are not rigorous enough to provide adequate measurement results, while in other cases are overly conservative and too costly to implement. Ideally, decision rules should be rigorous enough to match the criticality of the parameter being measured, while being flexible enough to be cost effective. The goal of a decision rule is to ensure that measurement processes provide data with a sufficient level of quality to support the decisions being made - no more, no less. This paper discusses the basic concepts of providing measurement-based evidence that end products meet specifications. Although relevant to all measurement-based conformance tests, the target audience is the MTE end-user, which is anyone using MTE other than calibration service providers. Topics include measurement fundamentals, the associated decision risks, verifying conformance to specifications, and basic measurement

  17. The Biological Bases of Conformity

    Directory of Open Access Journals (Sweden)

    Thomas Joshau Henry Morgan

    2012-06-01

    Full Text Available Humans are characterized by an extreme dependence on culturally transmitted information and recent formal theory predicts that natural selection should favour adaptive learning strategies that facilitate effective use of social information in decision making. One strategy that has attracted particular attention is conformist transmission, defined as the disproportionately likely adoption of the most common variant. Conformity has historically been emphasized as significant in the social psychology literature, and recently there have also been reports of conformist behaviour in nonhuman animals. However, mathematical analyses differ in how important and widespread they expect conformity to be, and relevant experimental work is scarce, and generates findings that are both mutually contradictory and inconsistent with the predictions of the models. We review the relevant literature considering the causation, function, history and ontogeny of conformity and describe a computer-based experiment on human subjects that we carried out in order to resolve ambiguities. We found that only when many demonstrators were available and subjects were uncertain was subject behaviour conformist. A further analysis found that the underlying response to social information alone was generally conformist. Thus, our data are consistent with a conformist use of social information, but as subject’s behaviour is the result of both social and asocial influences, the resultant behaviour may not be conformist. We end by relating these findings to an embryonic cognitive neuroscience literature that has recently begun to explore the neural bases of social learning. Here conformist transmission may be a particularly useful case study, not only because there are well-defined and tractable opportunities to characterize the biological underpinnings of this form of social learning, but also because early findings imply that humans may possess specific cognitive adaptations for

  18. Conformal covariance of general relativity

    International Nuclear Information System (INIS)

    Ionescu-Pallas, N.; Gottlieb, I.

    1980-01-01

    The Einstein's equations of General Relativity are written in a conformal metric, resulting as a consequence of geometrizing the pressure forces. Accordingly, the trajectory of a test body pursues a geodetic line even inside the source of gravitational field. Moreover, the pressure, entering the perfect fluid scheme, may be replaced by a certain scalar interaction. This new manner of interpreting General Relativity is then applied to Cosmology, in order to build up a model of Universe whose static limit should coincide with that of Einstein. At the same time, the cosmological constant is connected to the scalar interaction acquiring a plausible explanation. (author)

  19. Toward TeV Conformality

    International Nuclear Information System (INIS)

    Appelquist, T.; Fleming, G. T.; Neil, E. T.; Avakian, A.; Babich, R.; Brower, R. C.; Cohen, S. D.; Rebbi, C.; Schaich, D.; Cheng, M.; Vranas, P.; Clark, M. A.; Kiskis, J.; Osborn, J. C.

    2010-01-01

    We study the chiral properties of an SU(3) gauge theory with N f massless Dirac fermions in the fundamental representation when N f is increased from 2 to 6. For N f =2, our lattice simulations lead to a value of /F 3 , where F is the Nambu-Goldstone-boson decay constant and is the chiral condensate, which agrees with the measured QCD value. For N f =6, this ratio shows significant enhancement, presaging an even larger enhancement anticipated as N f increases further, toward the critical value for transition from confinement to infrared conformality.

  20. Introduction to twisted conformal fields

    International Nuclear Information System (INIS)

    Kazama, Y.

    1988-01-01

    A pedagogical account is given of the recent developments in the theory of twisted conformal fields. Among other things, the main part of the lecture concerns the construction of the twist-emission vertex operator, which is a generalization of the fermion emission vertex in the superstring theory. Several different forms of the vertex are derived and their mutural relationships are clarified. In this paper, the authors include a brief survey of the history of the fermion emission vertex, as it offers a good perspective in which to appreciate the logical development

  1. Evaluation of errors set-up and setting margins calculation in treatments 3-D conformal radiotherapy; Evaluacion de errores de set-up y calculo de margenes de configuracion en tratamientos de radioterapia CONFORMADA 3-D

    Energy Technology Data Exchange (ETDEWEB)

    Donis, S.; Robayna, B.; Gonzalez, A.; Hernandez Armas, J.

    2011-07-01

    The use of IGRT techniques provide knowledge of the mistakes made in the positioning of a patient, to population studies and estimate the margins for each population.In this paper we evaluate the errors of set-up in 3 different locations and from these margins are calculated configuration (SM).

  2. Generative Models of Conformational Dynamics

    Science.gov (United States)

    Langmead, Christopher James

    2014-01-01

    Atomistic simulations of the conformational dynamics of proteins can be performed using either Molecular Dynamics or Monte Carlo procedures. The ensembles of three-dimensional structures produced during simulation can be analyzed in a number of ways to elucidate the thermodynamic and kinetic properties of the system. The goal of this chapter is to review both traditional and emerging methods for learning generative models from atomistic simulation data. Here, the term ‘generative’ refers to a model of the joint probability distribution over the behaviors of the constituent atoms. In the context of molecular modeling, generative models reveal the correlation structure between the atoms, and may be used to predict how the system will respond to structural perturbations. We begin by discussing traditional methods, which produce multivariate Gaussian models. We then discuss GAMELAN (GrAphical Models of Energy LANdscapes), which produces generative models of complex, non-Gaussian conformational dynamics (e.g., allostery, binding, folding, etc) from long timescale simulation data. PMID:24446358

  3. On bidimensional Lagrangian conformal models

    International Nuclear Information System (INIS)

    Lazzarini, S.

    1990-04-01

    The main topic of this thesis is the study of Conformal Field Theories defined on an arbitrary compact Riemann surface without boundary. The Beltrami parametrization of complexe structures endowing such a surface provides a local bidimensional diffeomorphism invariance of the theory and the holomorphic factorization. The perturbative quantization a la Feynman is then constrained by local factorized Ward identities. The renormalization is analysed in the Esptein-Glaser scheme. A first part deals with the simplest free field models where one checks the interesting conjecture that renormalized perturbative expansions could be resumed by a Polyakov's formula which is a Wess-Zumino action for the diffeomorphism anomaly. For a higher genus surface, only a differential version is proposed. The second part of this thesis is devoted to the characterization of some observables of the free bosonic string in the corresponding gauge theory with the aid of the nilpotent Slavnov s-operator. It is conjectured that part of the observables of this theory is labelled by the local cohomology of s modulo d and corresponds to the vertex operators, as it is verified for the tachyon vertex in the conformal gauge [fr

  4. Focused conformational sampling in proteins

    Science.gov (United States)

    Bacci, Marco; Langini, Cassiano; Vymětal, Jiří; Caflisch, Amedeo; Vitalis, Andreas

    2017-11-01

    A detailed understanding of the conformational dynamics of biological molecules is difficult to obtain by experimental techniques due to resolution limitations in both time and space. Computer simulations avoid these in theory but are often too short to sample rare events reliably. Here we show that the progress index-guided sampling (PIGS) protocol can be used to enhance the sampling of rare events in selected parts of biomolecules without perturbing the remainder of the system. The method is very easy to use as it only requires as essential input a set of several features representing the parts of interest sufficiently. In this feature space, new states are discovered by spontaneous fluctuations alone and in unsupervised fashion. Because there are no energetic biases acting on phase space variables or projections thereof, the trajectories PIGS generates can be analyzed directly in the framework of transition networks. We demonstrate the possibility and usefulness of such focused explorations of biomolecules with two loops that are part of the binding sites of bromodomains, a family of epigenetic "reader" modules. This real-life application uncovers states that are structurally and kinetically far away from the initial crystallographic structures and are also metastable. Representative conformations are intended to be used in future high-throughput virtual screening campaigns.

  5. Cirurgia conservadora, radioterapia externa e reforço de dose com braquiterapia de alta taxa de dose: uma nova perspectiva no tratamento de sarcomas de partes moles do adulto Limb-sparing surgery, external beam radiotherapy and boost with high-dose rate brachytherapy: a new perspective for the treatment of soft tissue sarcomas in adults

    Directory of Open Access Journals (Sweden)

    Antonio Cássio Assis Pellizzon

    2002-03-01

    Full Text Available OBJETIVO: Avaliar a influência no controle local de pacientes adultos e portadores de sarcoma de partes moles em extremidades e submetidos a cirurgia conservadora do membro, com braquiterapia de alta taxa de dose (BATD como reforço para a radioterapia externa (RT. MATERIAL E MÉTODOS: Foram avaliados 16 pacientes tratados, de 1993 até 1999. A RT foi utilizada com finalidade pré ou pós-operatória (30--55 Gy e BATD com dose de 18--36 Gy (fx 3--6 Gy BID. Com base no modelo linear quadrático calculou-se a dose efetiva biológica ("biological effective dose" - BED para o tumor e comparou-se seu valor a dados da literatura internacional, que utiliza tratamentos com RT e braquiterapia de baixa taxa de dose (BBTD. RESULTADOS: Os valores médios e medianos da BED para os sarcomas de partes moles foram de 78,5 Gy7 e 80 Gy7. A análise univariada mostrou que a BED para o tumor, quando utilizada BATD, era semelhante ao valor de 83 Gy7 quando utilizada BBTD (p = 0,008. As taxas de controle local, sobrevida livre de doença e sobrevida global atuarial em cinco anos foram de 83,2%, 75% e 93,7%, respectivamente. CONCLUSÕES: A BATD, quando utilizada como método complementar no reforço de dose da RT no tratamento conservador dos sarcomas de partes moles, apresenta taxas de controle local equiparáveis às da literatura internacional; no entanto, estudos com número maior de pacientes e período maior de seguimento são ainda necessários para determinar o verdadeiro potencial da BATD em substituir a BBTD.PURPOSE: To evaluate the influence on local control in adult patients with soft tissue sarcomas of the limbs that underwent limb-sparing surgery and high-dose rate brachytherapy (HDRB in association with teletherapy. MATERIAL AND METHODS: Sixteen patients treated from 1993 to 1999 were reviewed. Teletherapy was used pre- or postoperatively (30--55 Gy in association with HDRB in a dose range of 18--36 Gy (fx 3--6 Gy BID. The linear quadratic model was

  6. Conformal symmetries of FRW accelerating cosmologies

    International Nuclear Information System (INIS)

    Kehagias, A.; Riotto, A.

    2014-01-01

    We show that any accelerating Friedmann–Robertson–Walker (FRW) cosmology with equation of state w<−1/3 (and therefore not only a de Sitter stage with w=−1) exhibits three-dimensional conformal symmetry on future constant-time hypersurfaces if the bulk theory is invariant under bulk conformal Killing vectors. We also offer an alternative derivation of this result in terms of conformal Killing vectors and show that long wavelength comoving curvature perturbations of the perturbed FRW metric are just conformal Killing motions of the FRW background. We then extend the boundary conformal symmetry to the bulk for accelerating cosmologies. Our findings indicate that one can easily generate perturbations of scalar fields which are not only scale invariant, but also fully conformally invariant on super-Hubble scales. Measuring a scale-invariant power spectrum for the cosmological perturbation does not automatically imply that the universe went through a de Sitter stage

  7. Maxwell equations in conformal invariant electrodynamics

    International Nuclear Information System (INIS)

    Fradkin, E.S.; AN SSSR, Novosibirsk. Inst. Avtomatiki i Ehlektrometrii); Kozhevnikov, A.A.; Palchik, M.Ya.; Pomeransky, A.A.

    1983-01-01

    We consider a conformal invariant formulation of quantum electrodynamics. Conformal invariance is achieved with a specific mathematical construction based on the indecomposable representations of the conformal group associated with the electromagnetic potential and current. As a corolary of this construction modified expressions for the 3-point Green functions are obtained which both contain transverse parts. They make it possible to formulate a conformal invariant skeleton perturbation theory. It is also shown that the Euclidean Maxwell equations in conformal electrodynamics are manifestations of its kinematical structure: in the case of the 3-point Green functions these equations follow (up to constants) from the conformal invariance while in the case of higher Green functions they are equivalent to the equality of the kernels of the partial wave expansions. This is the manifestation of the mathematical fast of a (partial) equivalence of the representations associated with the potential, current and the field tensor. (orig.)

  8. Operator algebras and conformal field theory

    International Nuclear Information System (INIS)

    Gabbiani, F.; Froehlich, J.

    1993-01-01

    We define and study two-dimensional, chiral conformal field theory by the methods of algebraic field theory. We start by characterizing the vacuum sectors of such theories and show that, under very general hypotheses, their algebras of local observables are isomorphic to the unique hyperfinite type III 1 factor. The conformal net determined by the algebras of local observables is proven to satisfy Haag duality. The representation of the Moebius group (and presumably of the entire Virasoro algebra) on the vacuum sector of a conformal field theory is uniquely determined by the Tomita-Takesaki modular operators associated with its vacuum state and its conformal net. We then develop the theory of Mebius covariant representations of a conformal net, using methods of Doplicher, Haag and Roberts. We apply our results to the representation theory of loop groups. Our analysis is motivated by the desire to find a 'background-independent' formulation of conformal field theories. (orig.)

  9. Measuring the mechanical properties of molecular conformers

    Science.gov (United States)

    Jarvis, S. P.; Taylor, S.; Baran, J. D.; Champness, N. R.; Larsson, J. A.; Moriarty, P.

    2015-09-01

    Scanning probe-actuated single molecule manipulation has proven to be an exceptionally powerful tool for the systematic atomic-scale interrogation of molecular adsorbates. To date, however, the extent to which molecular conformation affects the force required to push or pull a single molecule has not been explored. Here we probe the mechanochemical response of two tetra(4-bromophenyl)porphyrin conformers using non-contact atomic force microscopy where we find a large difference between the lateral forces required for manipulation. Remarkably, despite sharing very similar adsorption characteristics, variations in the potential energy surface are capable of prohibiting probe-induced positioning of one conformer, while simultaneously permitting manipulation of the alternative conformational form. Our results are interpreted in the context of dispersion-corrected density functional theory calculations which reveal significant differences in the diffusion barriers for each conformer. These results demonstrate that conformational variation significantly modifies the mechanical response of even simple porpyhrins, potentially affecting many other flexible molecules.

  10. Evaluation of <em>HER2em> Gene Amplification in Breast Cancer Using Nuclei Microarray <em>in em>S>itu em>Hybridization

    Directory of Open Access Journals (Sweden)

    Xuefeng Zhang

    2012-05-01

    Full Text Available Fluorescence<em> em>>in situ em>hybridization (FISH assay is considered the “gold standard” in evaluating <em>HER2/neu (HER2em> gene status. However, FISH detection is costly and time consuming. Thus, we established nuclei microarray with extracted intact nuclei from paraffin embedded breast cancer tissues for FISH detection. The nuclei microarray FISH (NMFISH technology serves as a useful platform for analyzing <em>HER2em> gene/chromosome 17 centromere ratio. We examined <em>HER2em> gene status in 152 cases of invasive ductal carcinomas of the breast that were resected surgically with FISH and NMFISH. <em>HER2em> gene amplification status was classified according to the guidelines of the American Society of Clinical Oncology and College of American Pathologists (ASCO/CAP. Comparison of the cut-off values for <em>HER2em>/chromosome 17 centromere copy number ratio obtained by NMFISH and FISH showed that there was almost perfect agreement between the two methods (κ coefficient 0.920. The results of the two methods were almost consistent for the evaluation of <em>HER2em> gene counts. The present study proved that NMFISH is comparable with FISH for evaluating <em>HER2em> gene status. The use of nuclei microarray technology is highly efficient, time and reagent conserving and inexpensive.

  11. Lattice models and conformal field theories

    International Nuclear Information System (INIS)

    Saleur, H.

    1988-01-01

    Theoretical studies concerning the connection between critical physical systems and the conformal theories are reviewed. The conformal theory associated to a critical (integrable) lattice model is derived. The obtention of the central charge, critical exponents and torus partition function, using renormalization group arguments, is shown. The quantum group structure, in the integrable lattice models, and the theory of Visaro algebra representations are discussed. The relations between off-critical integrable models and conformal theories, in finite geometries, are studied

  12. Multichannel conformal blocks for scattering amplitudes

    Science.gov (United States)

    Belitsky, A. V.

    2018-05-01

    By performing resummation of small fermion-antifermion pairs within the pentagon form factor program to scattering amplitudes in planar N = 4 superYang-Mills theory, we construct multichannel conformal blocks within the flux-tube picture for N-sided NMHV polygons. This procedure is equivalent to summation of descendants of conformal primaries in the OPE framework. The resulting conformal partial waves are determined by multivariable hypergeometric series of Lauricella-Saran type.

  13. Conformal hyperbolicity of Lorentzian warped products

    International Nuclear Information System (INIS)

    Markowitz, M.J.

    1982-01-01

    A space-time M is said to be conformally hyperbolic if the intrinsic conformal Lorentz pseudodistance dsub(M) is a true distance. In this paper criteria are derived which insure the conformal hyperbolicity of certain space-times which are generalizations of the Robertson-Walker spaces. Then dsub(M) is determined explicitly for Einstein-de Sitter space, and important cosmological model. (author)

  14. Conformal hyperbolicity of Lorentzian warped products

    Energy Technology Data Exchange (ETDEWEB)

    Markowitz, M.J. (Chicago Univ., IL (USA). Dept. of Mathematics)

    1982-12-01

    A space-time M is said to be conformally hyperbolic if the intrinsic conformal Lorentz pseudodistance dsub(M) is a true distance. In this paper criteria are derived which insure the conformal hyperbolicity of certain space-times which are generalizations of the Robertson-Walker spaces. Then dsub(M) is determined explicitly for Einstein-de Sitter space, and important cosmological model.

  15. Conformational changes in glycine tri- and hexapeptide

    DEFF Research Database (Denmark)

    Yakubovich, Alexander V.; Solov'yov, Ilia; Solov'yov, Andrey V.

    2006-01-01

    conformations and calculated the energy barriers for transitions between them. Using a thermodynamic approach, we have estimated the times of the characteristic transitions between these conformations. The results of our calculations have been compared with those obtained by other theoretical methods...... also investigated the influence of the secondary structure of polypeptide chains on the formation of the potential energy landscape. This analysis has been performed for the sheet and the helix conformations of chains of six amino acids....

  16. Reshaping of computational system for dosimetry in neutron and photons radiotherapy based in stochastic methods - SISCODES; Remodelagem do sistema computacional para dosimetria em radioterapia por neutrons e fotons baseado em metodos estocasticos - SISCODES

    Energy Technology Data Exchange (ETDEWEB)

    Trindade, Bruno Machado

    2011-02-15

    This work shows the remodeling of the Computer System for Dosimetry of Neutrons and Photons in Radiotherapy Based on Stochastic Methods . SISCODES. The initial description and status, the alterations and expansions (proposed and concluded), and the latest system development status are shown. The SISCODES is a system that allows the execution of a 3D computational planning in radiation therapy, based on MCNP5 nuclear particle transport code. The SISCODES provides tools to build a patient's voxels model, to define a treatment planning, to simulate this planning, and to view the results of the simulation. The SISCODES implements a database of tissues, sources and nuclear data and an interface to access then. The graphical SISCODES modules were rewritten or were implemented using C++ language and GTKmm library. Studies about dose deviations were performed simulating a homogeneous water phantom as analogue of the human body in radiotherapy planning and a heterogeneous voxel phantom, pointing out possible dose miscalculations. The Soft-RT and PROPLAN computer codes that do interface with SISCODES are described. A set of voxels models created on the SISCODES are presented with its respective sizes and resolutions. To demonstrate the use of SISCODES, examples of radiation therapy and dosimetry simulations for prostate and heart are shown. Three protocols were simulated on the heart voxel model: Sm-153 filled balloon and P-32 stent, to prevent angioplasty restenosis; and Tl-201 myocardial perfusion, to imaging. Teletherapy with 6MV and 15MV beams were simulated to the prostate, and brachytherapy with I-125 seeds. The results of these simulations are shown on isodose curves and on dose-volume histograms. The SISCODES shows to be a useful tool for research of new radiation therapy treatments and, in future, can also be useful in medical practice. At the end, future improvements are proposed. I hope this work can contribute to develop more effective radiation therapy treatments. (author)

  17. Quantitative analysis of results of quality control tests in linear accelerators used in radiotherapy; Analise quantitativa dos resultados de testes de controle de qualidade em aceleradores lineares usados em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Passaro, Bruno M.; Rodrigues, Laura N. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Videira, Heber S., E-mail: bruno.passaro@gmail.com [Universidade de Sao Paulo (HCFMRP/USP), Sao Paulo, SP (Brazil). Faculdade de Medicina. Hospital das Clinicas

    2013-04-15

    The aim of this study is to assess and analyze the stability of the calibration factor of three linear accelerators, as well as the other dosimetric parameters normally included in a program of quality control in radiotherapy. The average calibration factors of the accelerators for the period of approximately four years for the Clinac 600C and Clinac 6EX were (0.998±0.012) and (0.996±0.014), respectively. For the Clinac 2100CD 6 MV and 15 MV was (1.008±0.009) and (1.006±0.010), respectively, in a period of approximately four years. The data of the calibration factors were divided into four subgroups for a more detailed analysis of behavior over the years. Through statistical analysis of calibration factors, we found that for the 600C and Clinacs 2100CD, is an expected probability that more than 90% of cases the values are within acceptable ranges according to TG-142, while for the Clinac 6EX is expected around 85% since this had several exchanges of accelerator components. The values of TPR20,10 of three accelerators are practically constant and within acceptable limits according to the TG-142. It can be concluded that a detailed study of data from the calibration factor of the accelerators and TPR{sub 20},{sub 10} from a quantitative point of view, is extremely useful in a quality assurance program. (author)

  18. Proposal of procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions; Proposta de procedimentos para evitar erros em radioterapia baseados em licoes aprendidas de exposicoes acidentais

    Energy Technology Data Exchange (ETDEWEB)

    Bueno, Giselle Oliveira Vieira

    2007-07-01

    In order to consider some procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions and in accordance with information contained in international reports elaborated by International Atomic Energy Agency (IAEA) and of the data base availability by the European group Radiation Oncology Safety Information System (ROSIS) on the events, a research of the occurred errors was performed. For the evaluation of the incidents a data base based in the ROSIS and added plus a parameter was created 'type of error'. All the stored data make possible the evaluation of the 839 incidents in terms of frequency of the type of error, the process of detention, the number of reached patients and the degree of severity. Of the 50 types of found errors, the type of error more frequently was 'incorrect treatment coordinate', confirmed with the data of literature and representing 28,96 por cent of the total of the incidents. The results showed 44,44 por cent are discovered at the moment of the treatment and that the process of verification of the fiche or clinical revision of the patient is a verification more occurred insurance and in 43,33 por cent of the searched events. The results indicated that more than 50 por cent of the incidents the severity degree are void and approximately 62 por cent a patient are affected during the accomplishment of the radiotherapy. This work showed that to analyze the data base according to methodology proposal for Klein et al.; for Reason, and Dunscombe et al. is interesting to insert more characteristic detailed in the data base such as: the number of fractions for affected patient, number of fields of treatment for fraction that was affected, shunting line of the prescribed dose and shunting line of the volume prescribed in all the registered in cadastral map events. Some causes exist that can lead the errors when patient they are submitted to the radiotherapy. Some measures can be taken so that these errors do not occur as: to carry through dosimetry in vivo 'off-axis' with diode to reduce the use of the incorrect direction of the wedge; to use values of the vertical distance with pointer of optic distance (SSD) to prevent error of distance of treatment; to use the system of transference of data DICOM-RT between the stations of work of the planning of treatment and the simulation, being increased the efficiency and accuracy in the treatment; to manually consider the redundancy in the verifications of the calculations carried through for computer or; to use a computerized system of register and verification of the treatment; preventing errors in the which had daily treatments to the incorrect election of the treatment parameters; to implant a magnetic card of identification of the patient with photo, identification number, name of the institution, name of the department, the date of the first emission and responsible doctor to prevent errors of identification and register and could all be used in the process of the treatment. Of this form, these procedures can prevent incident more in radiotherapy and increase the security of the patients. (author)

  19. Implementation of a laboratory for manufacture, repair and electric calibration of dosemeters based in ionization chambers utilized in radiotherapy; Implementacao de um laboratorio para manutencao, reparo e calibracao eletrica de dosimetros baseados em camaras de ionizacao, utilizados em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Becker, P.H.B.; Peres, M.A.L.; Moreira, A.J.C.; Nette, H.P. [Instituto de Radioprotecao e Dosimetria. Av. Salvador Allende S/N. Barra de Tijuca CEP: 22780-160. Caixa Postal: 37750 Rio de Janeiro-RJ (Brazil)

    1998-12-31

    Manufacturers of ionization chamber dosimeters for radiotherapy maintain only sales representatives in Brazil with no servicing capability causing difficulties to customers/users to get broken equipment back into operation. Aiming to partially solve this problem, a laboratory for maintenance, repair and electrical calibration was started in 1995 with the support of a two year IAEA Technical Assistance Project (BRA/1/031). (Author)

  20. Proposal of procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions; Proposta de procedimentos para evitar erros em radioterapia baseados em licoes aprendidas de exposicoes acidentais

    Energy Technology Data Exchange (ETDEWEB)

    Bueno, Giselle Oliveira Vieira

    2007-07-01

    In order to consider some procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions and in accordance with information contained in international reports elaborated by International Atomic Energy Agency (IAEA) and of the data base availability by the European group Radiation Oncology Safety Information System (ROSIS) on the events, a research of the occurred errors was performed. For the evaluation of the incidents a data base based in the ROSIS and added plus a parameter was created 'type of error'. All the stored data make possible the evaluation of the 839 incidents in terms of frequency of the type of error, the process of detention, the number of reached patients and the degree of severity. Of the 50 types of found errors, the type of error more frequently was 'incorrect treatment coordinate', confirmed with the data of literature and representing 28,96 por cent of the total of the incidents. The results showed 44,44 por cent are discovered at the moment of the treatment and that the process of verification of the fiche or clinical revision of the patient is a verification more occurred insurance and in 43,33 por cent of the searched events. The results indicated that more than 50 por cent of the incidents the severity degree are void and approximately 62 por cent a patient are affected during the accomplishment of the radiotherapy. This work showed that to analyze the data base according to methodology proposal for Klein et al.; for Reason, and Dunscombe et al. is interesting to insert more characteristic detailed in the data base such as: the number of fractions for affected patient, number of fields of treatment for fraction that was affected, shunting line of the prescribed dose and shunting line of the volume prescribed in all the registered in cadastral map events. Some causes exist that can lead the errors when patient they are submitted to the radiotherapy. Some measures can be taken so that these errors do not occur as: to carry through dosimetry in vivo 'off-axis' with diode to reduce the use of the incorrect direction of the wedge; to use values of the vertical distance with pointer of optic distance (SSD) to prevent error of distance of treatment; to use the system of transference of data DICOM-RT between the stations of work of the planning of treatment and the simulation, being increased the efficiency and accuracy in the treatment; to manually consider the redundancy in the verifications of the calculations carried through for computer or; to use a computerized system of register and verification of the treatment; preventing errors in the which had daily treatments to the incorrect election of the treatment parameters; to implant a magnetic card of identification of the patient with photo, identification number, name of the institution, name of the department, the date of the first emission and responsible doctor to prevent errors of identification and register and could all be used in the process of the treatment. Of this form, these procedures can prevent incident more in radiotherapy and increase the security of the patients. (author)

  1. Geometrical formulation of the conformal Ward identity

    International Nuclear Information System (INIS)

    Kachkachi, M.

    2002-08-01

    In this paper we use deep ideas in complex geometry that proved to be very powerful in unveiling the Polyakov measure on the moduli space of Riemann surfaces and lead to obtain the partition function of perturbative string theory for 2, 3, 4 loops. Indeed, a geometrical interpretation of the conformal Ward identity in two dimensional conformal field theory is proposed: the conformal anomaly is interpreted as a deformation of the complex structure of the basic Riemann surface. This point of view is in line with the modern trend of geometric quantizations that are based on deformations of classical structures. Then, we solve the conformal Ward identity by using this geometrical formalism. (author)

  2. Fabrication challenges associated with conformal optics

    Science.gov (United States)

    Schaefer, John; Eichholtz, Richard A.; Sulzbach, Frank C.

    2001-09-01

    A conformal optic is typically an optical window that conforms smoothly to the external shape of a system platform to improve aerodynamics. Conformal optics can be on-axis, such as an ogive missile dome, or off-axis, such as in a free form airplane wing. A common example of conformal optics is the automotive head light window that conforms to the body of the car aerodynamics and aesthetics. The unusual shape of conformal optics creates tremendous challenges for design, manufacturing, and testing. This paper will discuss fabrication methods that have been successfully demonstrated to produce conformal missile domes and associated wavefront corrector elements. It will identify challenges foreseen with more complex free-form configurations. Work presented in this paper was directed by the Precision Conformal Optics Consortium (PCOT). PCOT is comprised of both industrial and academic members who teamed to develop and demonstrate conformal optical systems suitable for insertion into future military programs. The consortium was funded under DARPA agreement number MDA972-96-9-08000.

  3. Gluon amplitudes as 2 d conformal correlators

    Science.gov (United States)

    Pasterski, Sabrina; Shao, Shu-Heng; Strominger, Andrew

    2017-10-01

    Recently, spin-one wave functions in four dimensions that are conformal primaries of the Lorentz group S L (2 ,C ) were constructed. We compute low-point, tree-level gluon scattering amplitudes in the space of these conformal primary wave functions. The answers have the same conformal covariance as correlators of spin-one primaries in a 2 d CFT. The Britto-Cachazo-Feng-Witten (BCFW) recursion relation between three- and four-point gluon amplitudes is recast into this conformal basis.

  4. Noncommutative geometry and twisted conformal symmetry

    International Nuclear Information System (INIS)

    Matlock, Peter

    2005-01-01

    The twist-deformed conformal algebra is constructed as a Hopf algebra with twisted coproduct. This allows for the definition of conformal symmetry in a noncommutative background geometry. The twisted coproduct is reviewed for the Poincare algebra and the construction is then extended to the full conformal algebra. The case of Moyal-type noncommutativity of the coordinates is considered. It is demonstrated that conformal invariance need not be viewed as incompatible with noncommutative geometry; the noncommutativity of the coordinates appears as a consequence of the twisting, as has been shown in the literature in the case of the twisted Poincare algebra

  5. Unconstrained multiplet in N=2 conformal supergravity

    International Nuclear Information System (INIS)

    Hayashi, Masahito; Uehara, Shozo.

    1985-02-01

    An unconstrained (general) multiplet was studied in N = 2 conformal supergravity. Transformation law, embedding formula and multiplication rule are explicitly presented at the linearized level. (author)

  6. Superintegrability of d-dimensional conformal blocks

    International Nuclear Information System (INIS)

    Isachenkov, Mikhail

    2016-02-01

    We observe that conformal blocks of scalar 4-point functions in a d-dimensional conformal field theory can mapped to eigenfunctions of a 2-particle hyperbolic Calogero-Sutherland Hamiltonian. The latter describes two coupled Poeschl-Teller particles. Their interaction, whose strength depends smoothly on the dimension d, is known to be superintegrable. Our observation enables us to exploit the rich mathematical literature on Calogero-Sutherland models in deriving various results for conformal field theory. These include an explicit construction of conformal blocks in terms of Heckman-Opdam hypergeometric functions and a remarkable duality that relates the blocks of theories in different dimensions.

  7. Superintegrability of d-dimensional conformal blocks

    Energy Technology Data Exchange (ETDEWEB)

    Isachenkov, Mikhail [Weizmann Institute of Science, Rehovot (Israel). Dept. of Particle Physics and Astronomy; Schomerus, Volker [DESY Theory Group, Hamburg (Germany)

    2016-02-15

    We observe that conformal blocks of scalar 4-point functions in a d-dimensional conformal field theory can mapped to eigenfunctions of a 2-particle hyperbolic Calogero-Sutherland Hamiltonian. The latter describes two coupled Poeschl-Teller particles. Their interaction, whose strength depends smoothly on the dimension d, is known to be superintegrable. Our observation enables us to exploit the rich mathematical literature on Calogero-Sutherland models in deriving various results for conformal field theory. These include an explicit construction of conformal blocks in terms of Heckman-Opdam hypergeometric functions and a remarkable duality that relates the blocks of theories in different dimensions.

  8. Riemann monodromy problem and conformal field theories

    International Nuclear Information System (INIS)

    Blok, B.

    1989-01-01

    A systematic analysis of the use of the Riemann monodromy problem for determining correlators (conformal blocks) on the sphere is presented. The monodromy data is constructed in terms of the braid matrices and gives a constraint on the noninteger part of the conformal dimensions of the primary fields. To determine the conformal blocks we need to know the order of singularities. We establish a criterion which tells us when the knowledge of the conformal dimensions of primary fields suffice to determine the blocks. When zero modes of the extended algebra are present the analysis is more difficult. In this case we give a conjecture that works for the SU(2) WZW case. (orig.)

  9. Rotational Spectroscopy Unveils Eleven Conformers of Adrenaline

    Science.gov (United States)

    Cabezas, C.; Cortijo, V.; Mata, S.; Lopez, J. C.; Alonso, J. L.

    2013-06-01

    Recent improvements in our LA-MB-FTMW instrumentation have allowed the characterization of eleven and eight conformers for the neurotransmitters adrenaline and noradrenaline respectively. The observation of this rich conformational behavior is in accordance with the recent observation of seven conformers for dopamine and in sharp contrast with the conformational reduction proposed for catecholamines. C. Cabezas, I. Peña, J. C. López, J. L. Alonso J. Phys. Chem. Lett. 2013, 4, 486. H. Mitsuda, M. Miyazaki, I. B. Nielsen, P. Carcabal,C. Dedonder, C. Jouvet, S. Ishiuchi, M. Fujii J. Phys. Chem. Lett. 2010, 1, 1130.

  10. Conformal Dimensions via Large Charge Expansion.

    Science.gov (United States)

    Banerjee, Debasish; Chandrasekharan, Shailesh; Orlando, Domenico

    2018-02-09

    We construct an efficient Monte Carlo algorithm that overcomes the severe signal-to-noise ratio problems and helps us to accurately compute the conformal dimensions of large-Q fields at the Wilson-Fisher fixed point in the O(2) universality class. Using it, we verify a recent proposal that conformal dimensions of strongly coupled conformal field theories with a global U(1) charge can be obtained via a series expansion in the inverse charge 1/Q. We find that the conformal dimensions of the lowest operator with a fixed charge Q are almost entirely determined by the first few terms in the series.

  11. Conformal maps between pseudo-Finsler spaces

    Science.gov (United States)

    Voicu, Nicoleta

    The paper aims to initiate a systematic study of conformal mappings between Finsler spacetimes and, more generally, between pseudo-Finsler spaces. This is done by extending several results in pseudo-Riemannian geometry which are necessary for field-theoretical applications and by proposing a technique that reduces some problems involving pseudo-Finslerian conformal vector fields to their pseudo-Riemannian counterparts. Also, we point out, by constructing classes of examples, that conformal groups of flat (locally Minkowskian) pseudo-Finsler spaces can be much richer than both flat Finslerian and pseudo-Euclidean conformal groups.

  12. A New Natural Lactone from <em>Dimocarpus> <em>longan> Lour. Seeds

    Directory of Open Access Journals (Sweden)

    Zhongjun Li

    2012-08-01

    Full Text Available A new natural product named longanlactone was isolated from <em>Dimocarpus> <em>longan> Lour. seeds. Its structure was determined as 3-(2-acetyl-1<em>H>-pyrrol-1-yl-5-(prop-2-yn-1-yldihydrofuran-2(3H-one by spectroscopic methods and HRESIMS.

  13. Conformal frame dependence of inflation

    International Nuclear Information System (INIS)

    Domènech, Guillem; Sasaki, Misao

    2015-01-01

    Physical equivalence between different conformal frames in scalar-tensor theory of gravity is a known fact. However, assuming that matter minimally couples to the metric of a particular frame, which we call the matter Jordan frame, the matter point of view of the universe may vary from frame to frame. Thus, there is a clear distinction between gravitational sector (curvature and scalar field) and matter sector. In this paper, focusing on a simple power-law inflation model in the Einstein frame, two examples are considered; a super-inflationary and a bouncing universe Jordan frames. Then we consider a spectator curvaton minimally coupled to a Jordan frame, and compute its contribution to the curvature perturbation power spectrum. In these specific examples, we find a blue tilt at short scales for the super-inflationary case, and a blue tilt at large scales for the bouncing case

  14. Conformable eddy current array delivery

    Science.gov (United States)

    Summan, Rahul; Pierce, Gareth; Macleod, Charles; Mineo, Carmelo; Riise, Jonathan; Morozov, Maxim; Dobie, Gordon; Bolton, Gary; Raude, Angélique; Dalpé, Colombe; Braumann, Johannes

    2016-02-01

    The external surface of stainless steel containers used for the interim storage of nuclear material may be subject to Atmospherically Induced Stress Corrosion Cracking (AISCC). The inspection of such containers poses a significant challenge due to the large quantities involved; therefore, automating the inspection process is of considerable interest. This paper reports upon a proof-of-concept project concerning the automated NDT of a set of test containers containing artificially generated AISCCs. An Eddy current array probe with a conformable padded surface from Eddyfi was used as the NDT sensor and end effector on a KUKA KR5 arc HW robot. A kinematically valid cylindrical raster scan path was designed using the KUKA|PRC path planning software. Custom software was then written to interface measurement acquisition from the Eddyfi hardware with the motion control of the robot. Preliminary results and analysis are presented from scanning two canisters.

  15. Conformal frame dependence of inflation

    Energy Technology Data Exchange (ETDEWEB)

    Domènech, Guillem; Sasaki, Misao, E-mail: guillem.domenech@yukawa.kyoto-u.ac.jp, E-mail: misao@yukawa.kyoto-u.ac.jp [Yukawa Institute for Theoretical Physics, Kyoto University, Kyoto 606-8502 (Japan)

    2015-04-01

    Physical equivalence between different conformal frames in scalar-tensor theory of gravity is a known fact. However, assuming that matter minimally couples to the metric of a particular frame, which we call the matter Jordan frame, the matter point of view of the universe may vary from frame to frame. Thus, there is a clear distinction between gravitational sector (curvature and scalar field) and matter sector. In this paper, focusing on a simple power-law inflation model in the Einstein frame, two examples are considered; a super-inflationary and a bouncing universe Jordan frames. Then we consider a spectator curvaton minimally coupled to a Jordan frame, and compute its contribution to the curvature perturbation power spectrum. In these specific examples, we find a blue tilt at short scales for the super-inflationary case, and a blue tilt at large scales for the bouncing case.

  16. Strings, conformal fields and topology

    International Nuclear Information System (INIS)

    Kaku, Michio

    1991-01-01

    String Theory has advanced at an astonishing pace in the last few years, and this book aims to acquaint the reader with the most active topics of research in the field. Building on the foundations laid in his Introduction to Superstrings, Professor Kaku discusses such topics as the classification of conformal string theories, knot theory, the Yang-Baxter relation, quantum groups, the non-polynominal closed string field theory, matrix models, and topological field theory. Several chapters review the fundamentals of string theory, making the presentation of the material self-contained while keeping overlap with the earlier book to a minimum. The book conveys the vitality of current research in string theory and places readers at its forefront. (orig.) With 40 figs. in 50 parts

  17. Light gauginos and conformal sequestering

    International Nuclear Information System (INIS)

    Hanaki, Kentaro; Ookouchi, Yutaka

    2011-01-01

    In a wide class of direct and semidirect gauge mediation models, it has been observed that the gaugino masses vanish at leading order. It implies that there is a hierarchy between the gaugino and sfermion masses, invoking a fine-tuning problem in the Higgs sector via radiative corrections. In this paper, we explore the possibility of solving this anomalously light gaugino problem exploiting strong conformal dynamics in the hidden sector. With a mild assumption on the anomalous dimensions of the hidden sector operators, we show that the next-to-leading order contributions to the gaugino masses can naturally be in the same order as the sfermion masses. The μ/B μ problem is also discussed.

  18. Reference Gene Selection in the Desert Plant <em>Eremosparton songoricuem>m>

    Directory of Open Access Journals (Sweden)

    Dao-Yuan Zhang

    2012-06-01

    Full Text Available <em>Eremosparton songoricum em>(Litv. Vass. (<em>E. songoricumem> is a rare and extremely drought-tolerant desert plant that holds promise as a model organism for the identification of genes associated with water deficit stress. Here, we cloned and evaluated the expression of eight candidate reference genes using quantitative real-time reverse transcriptase polymerase chain reactions. The expression of these candidate reference genes was analyzed in a diverse set of 20 samples including various <em>E. songoricumem> plant tissues exposed to multiple environmental stresses. GeNorm analysis indicated that expression stability varied between the reference genes in the different experimental conditions, but the two most stable reference genes were sufficient for normalization in most conditions.<em> EsEFem> and <em>Esα-TUB> were sufficient for various stress conditions, <em>EsEF> and <em>EsACT> were suitable for samples of differing germination stages, and <em>EsGAPDH>and <em>Es>UBQ em>were most stable across multiple adult tissue samples. The <em>Es18Sem> gene was unsuitable as a reference gene in our analysis. In addition, the expression level of the drought-stress related transcription factor <em>EsDREB2em>> em>verified the utility of<em> E. songoricumem> reference genes and indicated that no single gene was adequate for normalization on its own. This is the first systematic report on the selection of reference genes in <em>E. songoricumem>, and these data will facilitate future work on gene expression in this species.

  19. Overexposure of radiation therapy patients in Panama: problem recognition and follow-up measures La sobreexposición de pacientes tratados con radioterapia en Panamá: reconocimiento del problema y medidas de seguimiento

    Directory of Open Access Journals (Sweden)

    Cari Borrás

    2006-09-01

    125 non-overexposed patients who had been treated in the same time period and for the same cancer sites as the overexposed patients. The clinicians uncovered a larger recurrence of cervical cancers than expected. The finding prompted PAHO to launch an initiative for the accreditation of radiation oncology centers in Latin America and the Caribbean, working in collaboration with professional societies for radiation oncologists, medical physicists, and radiotherapy technologists. The Latin American Association for Radiation Oncology (Asociación Latinoamericana de Terapia Radiante Oncológica has established an accreditation commission. Accreditation will require that centers implement a comprehensive radiation oncology quality assurance program that follows international guidelines. Statistical data on patient outcomes will be collected in order to document needs in radiotherapy centers in Latin America and the Caribbean and to define future strategies for cancer treatment.Este informe resume y analiza la respuesta de varias organizaciones que brindaron asistencia al Instituto Oncológico Nacional (ION de Panamá después de la sobreexposición de 28 pacientes sometidos a radioterapia que ocurrió en el ION a finales de 2000 y principios de 2001. Además, se examinan las medidas de largo plazo adoptadas en el ION en respuesta al accidente de sobreexposición y las implicaciones que tiene este accidente para todos los centros de tratamiento oncológico en el mundo. En marzo de 2001 se le comunicaron al director del ION las reacciones adversas graves sufridas por algunos pacientes sometidos a radioterapia contra el cáncer. De los 478 pacientes tratados entre agosto de 2000 y marzo de 2001 por cánceres localizados en la región pélvica, tres habían fallecido, presumiblemente por sobredosis de radiación. A raíz de ello, el Gobierno de Panamá invitó a expertos internacionales a realizar una investigación a fondo de la situación. Entre los especialistas invitados

  20. The butane condensed matter conformational problem

    NARCIS (Netherlands)

    Weber, A.C.J.; de Lange, C.A.; Meerts, W.L.; Burnell, E.E.

    2010-01-01

    From the dipolar couplings of orientationally ordered n-butane obtained by NMR spectroscopy we have calculated conformer probabilities using the modified Chord (Cd) and Size-and-Shape (CI) models to estimate the conformational dependence of the order matrix. All calculation methods make use of

  1. Conformity to Peer Pressure in Preschool Children

    Science.gov (United States)

    Haun, Daniel B. M.; Tomasello, Michael

    2011-01-01

    Both adults and adolescents often conform their behavior and opinions to peer groups, even when they themselves know better. The current study investigated this phenomenon in 24 groups of 4 children between 4;2 and 4;9 years of age. Children often made their judgments conform to those of 3 peers, who had made obviously erroneous but unanimous…

  2. Dissecting the large-scale galactic conformity

    Science.gov (United States)

    Seo, Seongu

    2018-01-01

    Galactic conformity is an observed phenomenon that galaxies located in the same region have similar properties such as star formation rate, color, gas fraction, and so on. The conformity was first observed among galaxies within in the same halos (“one-halo conformity”). The one-halo conformity can be readily explained by mutual interactions among galaxies within a halo. Recent observations however further witnessed a puzzling connection among galaxies with no direct interaction. In particular, galaxies located within a sphere of ~5 Mpc radius tend to show similarities, even though the galaxies do not share common halos with each other ("two-halo conformity" or “large-scale conformity”). Using a cosmological hydrodynamic simulation, Illustris, we investigate the physical origin of the two-halo conformity and put forward two scenarios. First, back-splash galaxies are likely responsible for the large-scale conformity. They have evolved into red galaxies due to ram-pressure stripping in a given galaxy cluster and happen to reside now within a ~5 Mpc sphere. Second, galaxies in strong tidal field induced by large-scale structure also seem to give rise to the large-scale conformity. The strong tides suppress star formation in the galaxies. We discuss the importance of the large-scale conformity in the context of galaxy evolution.

  3. Conformal deformation of Riemann space and torsion

    International Nuclear Information System (INIS)

    Pyzh, V.M.

    1981-01-01

    Method for investigating conformal deformations of Riemann spaces using torsion tensor, which permits to reduce the second ' order equations for Killing vectors to the system of the first order equations, is presented. The method is illustrated using conformal deformations of dimer sphere as an example. A possibility of its use when studying more complex deformations is discussed [ru

  4. Conformal invariance and two-dimensional physics

    International Nuclear Information System (INIS)

    Zuber, J.B.

    1993-01-01

    Actually, physicists and mathematicians are very interested in conformal invariance: geometric transformations which keep angles. This symmetry is very important for two-dimensional systems as phase transitions, string theory or node mathematics. In this article, the author presents the conformal invariance and explains its usefulness

  5. Fusion rules in conformal field theory

    International Nuclear Information System (INIS)

    Fuchs, J.

    1993-06-01

    Several aspects of fusion rings and fusion rule algebras, and of their manifestations in two-dimensional (conformal) field theory, are described: diagonalization and the connection with modular invariance; the presentation in terms of quotients of polynomial rings; fusion graphs; various strategies that allow for a partial classification; and the role of the fusion rules in the conformal bootstrap programme. (orig.)

  6. A viewpoint on nearly conformally symmetric manifold

    International Nuclear Information System (INIS)

    Rahman, M.S.

    1990-06-01

    Some observations, with definition, on Nearly Conformally Symmetric (NCS) manifold are made. A number of theorems concerning conformal change of metric and parallel tensors on NCS manifolds are presented. It is illustrated that a manifold M = R n-1 x R + 1 , endowed with a special metric, is NCS but not of harmonic curvature. (author). 8 refs

  7. Closed forms for conformally flat Green's functions

    International Nuclear Information System (INIS)

    Brown, M.R.; Grove, P.G.; Ottewill, A.C.

    1981-01-01

    A closed form is obtained for the massless scalar Green's function on Rindler space. This is related by conformal transformation to the Green's function for a massless, conformally coupled scalar field on the open Einstein universe. A closed form is also obtained for the corresponding Green's function on the Einstein static universe. (author)

  8. Vertex operator algebras and conformal field theory

    International Nuclear Information System (INIS)

    Huang, Y.Z.

    1992-01-01

    This paper discusses conformal field theory, an important physical theory, describing both two-dimensional critical phenomena in condensed matter physics and classical motions of strings in string theory. The study of conformal field theory will deepen the understanding of these theories and will help to understand string theory conceptually. Besides its importance in physics, the beautiful and rich mathematical structure of conformal field theory has interested many mathematicians. New relations between different branches of mathematics, such as representations of infinite-dimensional Lie algebras and Lie groups, Riemann surfaces and algebraic curves, the Monster sporadic group, modular functions and modular forms, elliptic genera and elliptic cohomology, Calabi-Yau manifolds, tensor categories, and knot theory, are revealed in the study of conformal field theory. It is therefore believed that the study of the mathematics involved in conformal field theory will ultimately lead to new mathematical structures which would be important to both mathematics and physics

  9. Conformation Generation: The State of the Art.

    Science.gov (United States)

    Hawkins, Paul C D

    2017-08-28

    The generation of conformations for small molecules is a problem of continuing interest in cheminformatics and computational drug discovery. This review will present an overview of methods used to sample conformational space, focusing on those methods designed for organic molecules commonly of interest in drug discovery. Different approaches to both the sampling of conformational space and the scoring of conformational stability will be compared and contrasted, with an emphasis on those methods suitable for conformer sampling of large numbers of drug-like molecules. Particular attention will be devoted to the appropriate utilization of information from experimental solid-state structures in validating and evaluating the performance of these tools. The review will conclude with some areas worthy of further investigation.

  10. Conformal Symmetry Patterns in Baryon Spectra

    International Nuclear Information System (INIS)

    Kirchbach, Mariana; Compean, Cliffor B

    2011-01-01

    Attention is drawn to the fact that the spectra of the baryons of the lightest flavors, the nucleon and the Δ, carry quantum numbers characteristic for an unitary representation of the conformal group. We show that the above phenomenon is well explained for baryons whose internal structure is dominated by a quark-diquark configuration that resides in a conformally compactified Minkowski space time, R 1 x S 3 , and is described by means of the conformal scale equation there. The R 1 x S 3 space-time represents the boundary of the conformally compactified AdS 5 , on which one expects to encounter a conformal theory in accord with the gauge-gravity duality. Within this context, our model is congruent with AdS 5 /CFT 4 .

  11. Conformal symmetry in two-dimensional space: recursion representation of conformal block

    International Nuclear Information System (INIS)

    Zamolodchikov, A.B.

    1988-01-01

    The four-point conformal block plays an important part in the analysis of the conformally invariant operator algebra in two-dimensional space. The behavior of the conformal block is calculated in the present paper in the limit in which the dimension Δ of the intermediate operator tends to infinity. This makes it possible to construct a recursion relation for this function that connects the conformal block at arbitrary Δ to the blocks corresponding to the dimensions of the zero vectors in the degenerate representations of the Virasoro algebra. The relation is convenient for calculating the expansion of the conformal block in powers of the uniformizing parameters q = i π tau

  12. Avaliação do uso de extrato de timo (timulina em pacientes com neoplasia maligna submetidos ao tratamento cirúrgico

    Directory of Open Access Journals (Sweden)

    Célia Regina de Oliveira Garritano

    Full Text Available OBJETIVO: Avaliar a ação da timulina em pacientes com neoplasia maligna, submetidos ao tratamento, com e sem quimioterapia e radioterapia complementar (QT/RT. MÉTODO: Estudo retrospectivo realizado em 50 pacientes, analisando as variações das taxas de leucócitos, linfócitos totais e da relação de linfócitos CD4/CD8 após imunoestimulação com timulina. RESULTADOS: No grupo submetido à QT/RT ocorreu um aumento do número de leucócitos após seis meses em 43,33% dos casos, e em 83,33% após 12 meses. Com relação aos linfócitos totais, após seis meses, 63,33% apresentaram níveis maiores, e depois de 12 meses isto ocorreu em casos 90% dos casos. A relação de linfócitos CD4/CD8 mostrou um aumento em 66,66%, e em 90% depois após 6 e 12 meses respectivamente. A análise estatística se mostrou significante com o teste de ANOVA one way. No grupo não submetido à QT/RT a elevação dos níveis de leucócitos ocorreu em 85% dos pacientes aos seis meses e em 90% aos 12 meses. As taxas de linfócitos se elevaram em 60% dos casos em seis meses e em 85% após 12 meses. A relação CD4/CD8 se tornou maior tanto aos seis como aos 12 meses em 65%. A análise estatística mostrou relevância com o teste "t" de Student e o de ANOVA one way. Não houve necessidade de interrupção dos ciclos de QT/RT e nenhum paciente referiu intolerância à timulina. CONCLUSÃO: O uso da timulina foi capaz de restaurar a resposta imune, reduzir os danos imunossupressores e colaterais induzidos pela terapia antineoplásica e não apresentou efeitos colaterais.

  13. Conformal invariance in hydrodynamic turbulence

    International Nuclear Information System (INIS)

    Falkovich, Gregory

    2007-01-01

    This short survey is written by a physicist. It contains neither theorems nor precise definitions. Its main content is a description of the results of numerical solution of the equations of fluid mechanics in the regime of developed turbulence. Due to limitations of computers, the results are not very precise. Despite being neither exact nor rigorous, the findings may nevertheless be of interest for mathematicians. The main result is that the isolines of some scalar fields (vorticity, temperature) in two-dimensional turbulence belong to the class of conformally invariant curves called SLE (Scramm-Loewner evolution) curves. First, this enables one to predict and find a plethora of quantitative relations going far beyond what was known previously about turbulence. Second, it suggests relations between phenomena that seemed unrelated, like the Euler equation and critical percolation. Third, it shows that one is able to get exact analytic results in statistical hydrodynamics. In short, physicists have found something unexpected and hope that mathematicians can help to explain it.

  14. 47 CFR 2.1072 - Limitation on Declaration of Conformity.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Limitation on Declaration of Conformity. 2.1072... Conformity § 2.1072 Limitation on Declaration of Conformity. (a) The Declaration of Conformity signifies that...'s rules. (b) A Declaration of Conformity by the responsible party is effective until a termination...

  15. C-metric solution for conformal gravity with a conformally coupled scalar field

    Energy Technology Data Exchange (ETDEWEB)

    Meng, Kun, E-mail: mengkun@tjpu.edu.cn [School of Science, Tianjin Polytechnic University, Tianjin 300387 (China); Zhao, Liu, E-mail: lzhao@nankai.edu.cn [School of Physics, Nankai University, Tianjin 300071 (China)

    2017-02-15

    The C-metric solution of conformal gravity with a conformally coupled scalar field is presented. The solution belongs to the class of Petrov type D spacetimes and is conformal to the standard AdS C-metric appeared in vacuum Einstein gravity. For all parameter ranges, we identify some of the physically interesting static regions and the corresponding coordinate ranges. The solution may contain a black hole event horizon, an acceleration horizon, either of which may be cut by the conformal infinity or be hidden behind the conformal infinity. Since the model is conformally invariant, we also discussed the possible effects of the conformal gauge choices on the structure of the spacetime.

  16. Synthesis, Crystal Structure and Luminescent Property of Cd (II Complex with <em>N-Benzenesulphonyl-L>-leucine

    Directory of Open Access Journals (Sweden)

    Xishi Tai

    2012-09-01

    Full Text Available A new trinuclear Cd (II complex [Cd3(L6(2,2-bipyridine3] [L =<em> Nem>-phenylsulfonyl-L>-leucinato] has been synthesized and characterized by elemental analysis, IR and X-ray single crystal diffraction analysis. The results show that the complex belongs to the orthorhombic, space group<em> Pem>212121 with<em> aem> = 16.877(3 Å, <em>b> em>= 22.875(5 Å, <em>c em>= 29.495(6 Å, <em>α> em>= <emem>= <emem>= 90°, <em>V> em>= 11387(4 Å3, <em>Z> em>= 4, <em>Dc>= 1.416 μg·m−3, <emem>= 0.737 mm−1, <em>F> em>(000 = 4992, and final <em>R>1 = 0.0390, <em>ωR>2 = 0.0989. The complex comprises two seven-coordinated Cd (II atoms, with a N2O5 distorted pengonal bipyramidal coordination environment and a six-coordinated Cd (II atom, with a N2O4 distorted octahedral coordination environment. The molecules form one dimensional chain structure by the interaction of bridged carboxylato groups, hydrogen bonds and p-p interaction of 2,2-bipyridine. The luminescent properties of the Cd (II complex and <em>N-Benzenesulphonyl-L>-leucine in solid and in CH3OH solution also have been investigated.

  17. Understanding modern magnets through conformal mapping

    International Nuclear Information System (INIS)

    Halbach, K.

    1989-10-01

    I want to show with the help of a number of examples that conformal mapping is a unique and enormously powerful tool for thinking about, and solving, problems. Usually one has to write down only a few equations, and sometimes none at all exclamation point When I started getting involved in work for which conformal mapping seemed to be a powerful tool, I did not think that I would ever be able to use that technique successfully because it seemed to require a nearly encyclopedic memory, an impression that was strengthened when I saw K. Kober's Dictionary of Conformal Representations. This attitude changed when I started to realize that beyond the basics of the theory of a function of a complex variable, I needed to know only about a handful of conformal maps and procedures. Consequently, my second goal for this talk is to show that in most cases conformal mapping functions can be obtained by formulating the underlying physics appropriately. This means particularly that encyclopedic knowledge of conformal maps is not necessary for successful use of conformal mapping techniques. To demonstrate these facts I have chosen examples from an area of physics/engineering in which I am active, namely accelerator physics. In order to do that successfully I start with a brief introduction into high energy charged particle storage ring technology, even though not all examples used in this paper to elucidate my points come directly from this particular field of accelerator technology

  18. On functional representations of the conformal algebra

    Energy Technology Data Exchange (ETDEWEB)

    Rosten, Oliver J.

    2017-07-15

    Starting with conformally covariant correlation functions, a sequence of functional representations of the conformal algebra is constructed. A key step is the introduction of representations which involve an auxiliary functional. It is observed that these functionals are not arbitrary but rather must satisfy a pair of consistency equations corresponding to dilatation and special conformal invariance. In a particular representation, the former corresponds to the canonical form of the exact renormalization group equation specialized to a fixed point whereas the latter is new. This provides a concrete understanding of how conformal invariance is realized as a property of the Wilsonian effective action and the relationship to action-free formulations of conformal field theory. Subsequently, it is argued that the conformal Ward Identities serve to define a particular representation of the energy-momentum tensor. Consistency of this construction implies Polchinski's conditions for improving the energy-momentum tensor of a conformal field theory such that it is traceless. In the Wilsonian approach, the exactly marginal, redundant field which generates lines of physically equivalent fixed points is identified as the trace of the energy-momentum tensor. (orig.)

  19. Entanglement evolution across a conformal interface

    Science.gov (United States)

    Wen, Xueda; Wang, Yuxuan; Ryu, Shinsei

    2018-05-01

    For two-dimensional conformal field theories (CFTs) in the ground state, it is known that a conformal interface along the entanglement cut can suppress the entanglement entropy from to , where L is the length of the subsystem A, and is the effective central charge which depends on the transmission property of the conformal interface. In this work, by making use of conformal mappings, we show that a conformal interface has the same effect on entanglement evolution in non-equilibrium cases, including global, local and certain inhomogeneous quantum quenches. I.e. a conformal interface suppresses the time evolution of entanglement entropy by effectively replacing the central charge c with , where is exactly the same as that in the ground state case. We confirm this conclusion by a numerical study on a critical fermion chain. Furthermore, based on the quasi-particle picture, we conjecture that this conclusion holds for an arbitrary quantum quench in CFTs, as long as the initial state can be described by a regularized conformal boundary state.

  20. Conformational effects in photoelectron circular dichroism

    Science.gov (United States)

    Turchini, S.

    2017-12-01

    Photoelectron circular dichroism (PECD) is a novel type of spectroscopy, which presents surprising sensitivity to conformational effects in chiral systems. While classical photoelectron spectroscopy mainly responds to conformational effects in terms of energy level shifts, PECD provides a rich and detailed response to tiny changes in electronic and structural properties by means of the intensity dispersion of the circular dichroism as a function of photoelectron kinetic energy. In this work, the basics of PECD will be outlined, emphasizing the role of interference from the l,l+/- 1 outgoing partial wave of the photoelectron in the PECD transition matrix element, which is responsible for the extreme sensitivity to conformational effects. Examples using molecular systems and interfaces will shed light on the powerful application of PECD to classical conformational effects such as group substitution, isomerism, conformer population and clustering. Moreover, the PECD results will be reported in challenging new fields where conformations play a key role, such as vibrational effects, transient chirality and time- resolved experiments. To date, PECD has mostly been based on synchrotron radiation facilities, but it also has a future as a table-top lab experiment by means of multiphoton ionization. An important application of PECD as an analytical tool will be reported. The aim of this review is to illustrate that in PECD, the presence of conformational effects is essential for understanding a wide range of effects from a new perspective, making it different from classical spectroscopy.

  1. Conformity index for brain cancer patients

    International Nuclear Information System (INIS)

    Petkovska, Sonja; Tolevska, Cveta; Kraleva, Slavica; Petreska, Elena

    2010-01-01

    The purpose of this study is to present the level of conformity achieved by using 3D conformal radiotherapy for brain cancer patients. Conformity index is a helpful quantitative tool for assessing (evaluating) the quality of a treatment plan. Treatment plans made for ninety patients with brain tumor are worked on this paper. The patients are in supine position and immobilized with thermoplastic masks for the head. Computed tomography data sets with 5 mm scan thickness are used to create a 3D image. All structures of interest are contoured. In order to obtain an optimal dose distribution, treatment fields are fit around target volume with set-up margins of 7mm in each direction. The conformity index values are between 1.21 and 2.04. Value of 1.8 is exceeded in eighteen cases; nine of them are bigger than 1.9 and only three of them are above 2. The target volume for each of these extreme CI values is ideal covered (between 95% and 105% of the prescribed dose). The most acceptable conformity index value in this paper belongs to the plan with the lowest minimal dose (84.7%). It can be concluded that conformity index is necessary but not sufficient factor for assessing radiation treatment plan conformity. To be able to estimate the acceptability of some treatment plan in daily practice, additional information as minimal, maximal and mean dose into target volume, as well as health tissues coverage must be taken into account.(Author)

  2. Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing.

    Science.gov (United States)

    Snoberger, Aaron; Brettrager, Evan J; Smith, David M

    2018-06-18

    Protein degradation in all domains of life requires ATPases that unfold and inject proteins into compartmentalized proteolytic chambers. Proteasomal ATPases in eukaryotes and archaea contain poorly understood N-terminally conserved coiled-coil domains. In this study, we engineer disulfide crosslinks in the coiled-coils of the archaeal proteasomal ATPase (PAN) and report that its three identical coiled-coil domains can adopt three different conformations: (1) in-register and zipped, (2) in-register and partially unzipped, and (3) out-of-register. This conformational heterogeneity conflicts with PAN's symmetrical OB-coiled-coil crystal structure but resembles the conformational heterogeneity of the 26S proteasomal ATPases' coiled-coils. Furthermore, we find that one coiled-coil can be conformationally constrained even while unfolding substrates, and conformational changes in two of the coiled-coils regulate PAN switching between resting and active states. This switching functionally mimics similar states proposed for the 26S proteasome from cryo-EM. These findings thus build a mechanistic framework to understand regulation of proteasome activity.

  3. Evaluation of the treatment planning system of three-dimensional conformal external radiotherapy in Hospital Mexico of San Jose, Costa Rica

    International Nuclear Information System (INIS)

    Venegas Rojas, Deybith

    2014-01-01

    An evaluation and analysis are realized of dosimetry of the treatment planning system (TPS) of three-dimensional conformal external radiotherapy in the Servicio de Radioterapia of the Hospital Mexico of Costa Rica. An evaluation procedure is proposed based on IAEA-TECDOC-1540 document, and may continue to be applied periodically in this or other radiotherapy services. Tests realized have checked the representation of distances and electronics densities transferred to the TPS, match with those of real objects. The 16 tests applied have represented situations of real treatments with different configurations and beam modifiers in the equipment used daily. The tests have measured the absorbed dose to water in different significant points at different depths, using photon beams of 6 MeV and 18 MeV. The physical parameters of the tests were simulated. The absorbed dose has been calculated at specified points. The XiO and Eclipse TPS have been used with the calculation algorithms: Superposition, Convolution and AAA. The results of the calculations are evaluated with statistical methods and comparing them with the measurements of absorbed dose. A generalized tendency has been detected toward negative relative errors, implying an underestimation of the dose by the TPS; due to a difference found in the accelerator output factor respect to its commissioning. The AAA algorithm has determined a better performance, although with greater difficulties of calculus in the region of build-up. Convolution and Superposition algorithms have had similar performances and both have presented problems in high depths and out of edges of the fields. The result of the dosimetric evaluation has been satisfactory in real conditions of equipment; but several particularities have been found that should be reviewed and adjusted. The precision of the TPS has been adequate in the majority of situations important for treatment planning. [author] [es

  4. Conformation-dependent DNA attraction

    Science.gov (United States)

    Li, Weifeng; Nordenskiöld, Lars; Zhou, Ruhong; Mu, Yuguang

    2014-05-01

    Understanding how DNA molecules interact with other biomolecules is related to how they utilize their functions and is therefore critical for understanding their structure-function relationships. For a long time, the existence of Z-form DNA (a left-handed double helical version of DNA, instead of the common right-handed B-form) has puzzled the scientists, and the definitive biological significance of Z-DNA has not yet been clarified. In this study, the effects of DNA conformation in DNA-DNA interactions are explored by molecular dynamics simulations. Using umbrella sampling, we find that for both B- and Z-form DNA, surrounding Mg2+ ions always exert themselves to screen the Coulomb repulsion between DNA phosphates, resulting in very weak attractive force. On the contrary, a tight and stable bound state is discovered for Z-DNA in the presence of Mg2+ or Na+, benefiting from their hydrophobic nature. Based on the contact surface and a dewetting process analysis, a two-stage binding process of Z-DNA is outlined: two Z-DNA first attract each other through charge screening and Mg2+ bridges to phosphate groups in the same way as that of B-DNA, after which hydrophobic contacts of the deoxyribose groups are formed via a dewetting effect, resulting in stable attraction between two Z-DNA molecules. The highlighted hydrophobic nature of Z-DNA interaction from the current study may help to understand the biological functions of Z-DNA in gene transcription.Understanding how DNA molecules interact with other biomolecules is related to how they utilize their functions and is therefore critical for understanding their structure-function relationships. For a long time, the existence of Z-form DNA (a left-handed double helical version of DNA, instead of the common right-handed B-form) has puzzled the scientists, and the definitive biological significance of Z-DNA has not yet been clarified. In this study, the effects of DNA conformation in DNA-DNA interactions are explored by

  5. Spectra of conformal sigma models

    International Nuclear Information System (INIS)

    Tlapak, Vaclav

    2015-04-01

    In this thesis the spectra of conformal sigma models defined on (generalized) symmetric spaces are analysed. The spaces where sigma models are conformal without the addition of a Wess-Zumino term are supermanifolds, in other words spaces that include fermionic directions. After a brief review of the general construction of vertex operators and the background field expansion, we compute the diagonal terms of the one-loop anomalous dimensions of sigma models on semi-symmetric spaces. We find that the results are formally identical to the symmetric case. However, unlike for sigma models on symmetric spaces, off diagonal terms that lead to operator mixing are also present. These are not computed here. We then present a detailed analysis of the one-loop spectrum of the supersphere S 3 vertical stroke 2 sigma model as one of the simplest examples. The analysis illustrates the power and simplicity of the construction. We use this data to revisit a duality with the OSP(4 vertical stroke 2) Gross-Neveu model that was proposed by Candu and Saleur. With the help of a recent all-loop result for the anomalous dimension of (1)/(2)BPS operators of Gross-Neveu models, we are able to recover the entire zero-mode spectrum of the supersphere model. We also argue that the sigma model constraints and its equations of motion are implemented correctly in the Gross-Neveu model, including the one-loop data. The duality is further supported by a new all-loop result for the anomalous dimension of the ground states of the sigma model. However, higher-gradient operators cannot be completely recovered. It is possible that this discrepancy is related to a known instability of the sigma model. The instability of sigma models is due to symmetry preserving high-gradient operators that become relevant at arbitrarily small values of the coupling. This feature has been observed long ago in one-loop calculations of the O(N)-vector model and soon been realized to be a generic property of sigma models

  6. Conformation-dependent DNA attraction.

    Science.gov (United States)

    Li, Weifeng; Nordenskiöld, Lars; Zhou, Ruhong; Mu, Yuguang

    2014-06-21

    Understanding how DNA molecules interact with other biomolecules is related to how they utilize their functions and is therefore critical for understanding their structure-function relationships. For a long time, the existence of Z-form DNA (a left-handed double helical version of DNA, instead of the common right-handed B-form) has puzzled the scientists, and the definitive biological significance of Z-DNA has not yet been clarified. In this study, the effects of DNA conformation in DNA-DNA interactions are explored by molecular dynamics simulations. Using umbrella sampling, we find that for both B- and Z-form DNA, surrounding Mg(2+) ions always exert themselves to screen the Coulomb repulsion between DNA phosphates, resulting in very weak attractive force. On the contrary, a tight and stable bound state is discovered for Z-DNA in the presence of Mg(2+) or Na(+), benefiting from their hydrophobic nature. Based on the contact surface and a dewetting process analysis, a two-stage binding process of Z-DNA is outlined: two Z-DNA first attract each other through charge screening and Mg(2+) bridges to phosphate groups in the same way as that of B-DNA, after which hydrophobic contacts of the deoxyribose groups are formed via a dewetting effect, resulting in stable attraction between two Z-DNA molecules. The highlighted hydrophobic nature of Z-DNA interaction from the current study may help to understand the biological functions of Z-DNA in gene transcription.

  7. Willmore energy estimates in conformal Berger spheres

    International Nuclear Information System (INIS)

    Barros, Manuel; Ferrandez, Angel

    2011-01-01

    Highlights: → The Willmore energy is computed in a wide class of surfaces. → Isoperimetric inequalities for the Willmore energy of Hopf tori are obtained. → The best possible lower bound is achieved on isoareal Hopf tori. - Abstract: We obtain isoperimetric inequalities for the Willmore energy of Hopf tori in a wide class of conformal structures on the three sphere. This class includes, on the one hand, the family of conformal Berger spheres and, on the other hand, a one parameter family of Lorentzian conformal structures. This allows us to give the best possible lower bound of Willmore energies concerning isoareal Hopf tori.

  8. Dilogarithm identities in conformal field theory

    International Nuclear Information System (INIS)

    Nahm, W.; Recknagel, A.; Terhoeven, M.

    1992-11-01

    Dilogarithm identities for the central charges and conformal dimensions exist for at least large classes of rational conformally invariant quantum field theories in two dimensions. In many cases, proofs are not yet known but the numerical and structural evidence is convincing. In particular, close relations exist to fusion rules and partition identities. We describe some examples and ideas, and present conjectures useful for the classification of conformal theories. The mathematical structures seem to be dual to Thurston's program for the classification of 3-manifolds. (orig.)

  9. Conformal Gravity: Dark Matter and Dark Energy

    Directory of Open Access Journals (Sweden)

    Robert K. Nesbet

    2013-01-01

    Full Text Available This short review examines recent progress in understanding dark matter, dark energy, and galactic halos using theory that departs minimally from standard particle physics and cosmology. Strict conformal symmetry (local Weyl scaling covariance, postulated for all elementary massless fields, retains standard fermion and gauge boson theory but modifies Einstein–Hilbert general relativity and the Higgs scalar field model, with no new physical fields. Subgalactic phenomenology is retained. Without invoking dark matter, conformal gravity and a conformal Higgs model fit empirical data on galactic rotational velocities, galactic halos, and Hubble expansion including dark energy.

  10. The decomposition of global conformal invariants

    CERN Document Server

    Alexakis, Spyros

    2012-01-01

    This book addresses a basic question in differential geometry that was first considered by physicists Stanley Deser and Adam Schwimmer in 1993 in their study of conformal anomalies. The question concerns conformally invariant functionals on the space of Riemannian metrics over a given manifold. These functionals act on a metric by first constructing a Riemannian scalar out of it, and then integrating this scalar over the manifold. Suppose this integral remains invariant under conformal re-scalings of the underlying metric. What information can one then deduce about the Riemannian scalar? Dese

  11. Non-local Effects of Conformal Anomaly

    Science.gov (United States)

    Meissner, Krzysztof A.; Nicolai, Hermann

    2018-03-01

    It is shown that the nonlocal anomalous effective actions corresponding to the quantum breaking of the conformal symmetry can lead to observable modifications of Einstein's equations. The fact that Einstein's general relativity is in perfect agreement with all observations including cosmological or recently observed gravitational waves imposes strong restrictions on the field content of possible extensions of Einstein's theory: all viable theories should have vanishing conformal anomalies. It is shown that a complete cancellation of conformal anomalies in D=4 for both the C^2 invariant and the Euler (Gauss-Bonnet) invariant can only be achieved for N-extended supergravity multiplets with N ≥ 5.

  12. Static validation of licence conformance policies

    DEFF Research Database (Denmark)

    Hansen, Rene Rydhof; Nielson, Flemming; Nielson, Hanne Riis

    2008-01-01

    Policy conformance is a security property gaining importance due to commercial interest like Digital Rights Management. It is well known that static analysis can be used to validate a number of more classical security policies, such as discretionary and mandatory access control policies, as well...... as communication protocols using symmetric and asymmetric cryptography. In this work we show how to develop a Flow Logic for validating the conformance of client software with respect to a licence conformance policy. Our approach is sufficiently flexible that it extends to fully open systems that can admit new...

  13. Conformation sensitive charge transport in conjugated polymers

    International Nuclear Information System (INIS)

    Mattias Andersson, L.; Hedström, Svante; Persson, Petter

    2013-01-01

    Temperature dependent charge carrier mobility measurements using field effect transistors and density functional theory calculations are combined to show how the conformation dependent frontier orbital delocalization influences the hole- and electron mobilities in a donor-acceptor based polymer. A conformationally sensitive lowest unoccupied molecular orbital results in an electron mobility that decreases with increasing temperature above room temperature, while a conformationally stable highest occupied molecular orbital is consistent with a conventional hole mobility behavior and also proposed to be one of the reasons for why the material works well as a hole transporter in amorphous bulk heterojunction solar cells

  14. Multiresolution Computation of Conformal Structures of Surfaces

    Directory of Open Access Journals (Sweden)

    Xianfeng Gu

    2003-10-01

    Full Text Available An efficient multiresolution method to compute global conformal structures of nonzero genus triangle meshes is introduced. The homology, cohomology groups of meshes are computed explicitly, then a basis of harmonic one forms and a basis of holomorphic one forms are constructed. A progressive mesh is generated to represent the original surface at different resolutions. The conformal structure is computed for the coarse level first, then used as the estimation for that of the finer level, by using conjugate gradient method it can be refined to the conformal structure of the finer level.

  15. 77 FR 14979 - Transportation Conformity Rule Restructuring Amendments

    Science.gov (United States)

    2012-03-14

    ... Transportation Conformity Rule Restructuring Amendments AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: EPA is amending the transportation conformity rule to finalize provisions that were proposed on August 13, 2010. These amendments restructure several sections of the transportation conformity...

  16. Solid state conformational classification of eight-membered rings

    DEFF Research Database (Denmark)

    Pérez, J.; García, L.; Kessler, M.

    2005-01-01

    A statistical classification of the solid state conformation in the title complexes using data retrieved from the Cambridge Structural Database (CSD) has been made. Phosphate and phosphinate complexes show a chair conformation preferably. In phosphonate complexes, the most frequent conformations...

  17. SCit: web tools for protein side chain conformation analysis

    OpenAIRE

    Gautier, R.; Camproux, A.-C.; Tufféry, P.

    2004-01-01

    SCit is a web server providing services for protein side chain conformation analysis and side chain positioning. Specific services use the dependence of the side chain conformations on the local backbone conformation, which is described using a structural alphabet that describes the conformation of fragments of four-residue length in a limited library of structural prototypes. Based on this concept, SCit uses sets of rotameric conformations dependent on the local backbone conformation of each...

  18. Proposición de un programa de garantía de calidad de la radioterapia en los niños: aspectos médicos PROPOSITION OF A QUALITY ASSURANCE PROGRAM OF RADIOTHERAPY IN CHILDREN: MEDICAL ASPECTS

    Directory of Open Access Journals (Sweden)

    José Alert

    2005-03-01

    Full Text Available La radioterapia constituye una de las armas terapéuticas básicas en la atención de los tumores malignos de los niños. Para poder garantizar los objetivos del tratamiento radiante es preciso aplicar un Programa de Garantía de Calidad, que comprenda los aspectos médicos y físicos, estrechamente imbricados. En este trabajo nos referiremos a una proposición de Programa de Garantía de Calidad de la Radioterapia en los niños en sus aspectos médicos. El programa de sería aplicado a todo niño sometido a tratamiento radiante, y constituiría un sub-programa dentro del Programa de Garantía de Calidad Nacional. Entre los aspectos médicos incluye: a los programas o políticas de tratamiento; b los elementos técnicos y físicos, como controles en equipos de simulación, irradiación, etc., y la correcta aplicación diaria del tratamiento indicado y planificado y c revisiones periódicas de los programas de tratamiento, seguimiento de los casos y resultados obtenidos. Cada acápite comprende: 1 aspectos a auditar, y 2 cómo auditar. De todo lo anterior se infiere la necesidad de tener y aplicar un Programa de Garantía de Calidad del tratamiento radiante, que garantiza un tratamiento de calidad óptima.Radiotherapy is one of the basic therapeutic tools in the attention of malignant tumors in children. To guarantee the objectives of the radiant treatment it is necessary to apply a Quality Assurance Program comprising the medical and physical aspects closely related. In this paper, we refer to a proposition of the Quality Assurance Program of Radiotherapy in children in its medical aspects. The program will be applied to every child undergoing radiant treatment and it will be a subprogram within the National Quality Assurance Program. Among the medical aspects, we find: a the treatment programs or policies; b the technical and physical elements, such as controls in simulation equipment, irradiation, etc., and the correct daily application of the

  19. Conformal anomalies in curved space--time

    Energy Technology Data Exchange (ETDEWEB)

    Duncan, A.

    1976-11-01

    The general form of the conformal anomaly in a dimensionally regularized theory of massless fermions in a background metric is shown to be determined by the first few terms of weak field perturbation theory.

  20. Steffensen's integral inequality for conformable fractional integrals

    Directory of Open Access Journals (Sweden)

    Mehmet Zeki Sarikaya

    2017-09-01

    Full Text Available The aim of this paper is to establish some Steffensen’s type inequalities for conformable fractional integral. The results presented here would provide generalizations of those given in earlier works.

  1. Some Improvements of Conformable Fractional Integral Inequalities

    Directory of Open Access Journals (Sweden)

    Fuat Usta

    2017-07-01

    Full Text Available In this study, we wish to set up and present some new conformable fractional integral inequalities of the Gronwall type which have a great variety of implementation area in differential and integral equations.

  2. UV conformal window for asymptotic safety

    Science.gov (United States)

    Bond, Andrew D.; Litim, Daniel F.; Vazquez, Gustavo Medina; Steudtner, Tom

    2018-02-01

    Interacting fixed points in four-dimensional gauge theories coupled to matter are investigated using perturbation theory up to three loop order. It is shown how fixed points, scaling exponents, and anomalous dimensions are obtained as a systematic power series in a small parameter. The underlying ordering principle is explained and contrasted with conventional perturbation theory and Weyl consistency conditions. We then determine the conformal window with asymptotic safety from the complete next-to-next-to-leading order in perturbation theory. Limits for the conformal window arise due to fixed point mergers, the onset of strong coupling, or vacuum instability. A consistent picture is uncovered by comparing various levels of approximation. The theory remains perturbative in the entire conformal window, with vacuum stability dictating the tightest constraints. We also speculate about a secondary conformal window at strong coupling and estimate its lower limit. Implications for model building and cosmology are indicated.

  3. Timed Safety Automata and Logic Conformance

    National Research Council Canada - National Science Library

    Young, Frank

    1999-01-01

    Timed Logic Conformance (TLC) is used to verify the behavioral and timing properties of detailed digital circuits against abstract circuit specifications when both are modeled as Timed Safety Automata (TSA...

  4. Surface Design Based on Discrete Conformal Transformations

    Science.gov (United States)

    Duque, Carlos; Santangelo, Christian; Vouga, Etienne

    Conformal transformations are angle-preserving maps from one domain to another. Although angles are preserved, the lengths between arbitrary points are not generally conserved. As a consequence there is always a given amount of distortion associated to any conformal map. Different uses of such transformations can be found in various fields, but have been used by us to program non-uniformly swellable gel sheets to buckle into prescribed three dimensional shapes. In this work we apply circle packings as a kind of discrete conformal map in order to find conformal maps from the sphere to the plane that can be used as nearly uniform swelling patterns to program non-Euclidean sheets to buckle into spheres. We explore the possibility of tuning the area distortion to fit the experimental range of minimum and maximum swelling by modifying the boundary of the planar domain through the introduction of different cutting schemes.

  5. Conformal invariance of extended spinning particle mechanics

    International Nuclear Information System (INIS)

    Siegel, W.

    1988-01-01

    Recently a mechanics action has been considered with extended, local, one-dimensional supersymmetry. The authors show this action is conformally invariant in arbitrary spacetime dimensions, and derive the corresponding quantum mechanical restriction on the Lorentz representations it describes

  6. A Novel, Low-Cost Conformable Lander

    Data.gov (United States)

    National Aeronautics and Space Administration — The primary focus of this activity will be to outline a preliminary mechanical design for this conforming lander. Salient issues to be worked include (1) determining...

  7. Hidden conformal symmetry of extremal black holes

    International Nuclear Information System (INIS)

    Chen Bin; Long Jiang; Zhang Jiaju

    2010-01-01

    We study the hidden conformal symmetry of extremal black holes. We introduce a new set of conformal coordinates to write the SL(2,R) generators. We find that the Laplacian of the scalar field in many extremal black holes, including Kerr(-Newman), Reissner-Nordstrom, warped AdS 3 , and null warped black holes, could be written in terms of the SL(2,R) quadratic Casimir. This suggests that there exist dual conformal field theory (CFT) descriptions of these black holes. From the conformal coordinates, the temperatures of the dual CFTs could be read directly. For the extremal black hole, the Hawking temperature is vanishing. Correspondingly, only the left (right) temperature of the dual CFT is nonvanishing, and the excitations of the other sector are suppressed. In the probe limit, we compute the scattering amplitudes of the scalar off the extremal black holes and find perfect agreement with the CFT prediction.

  8. Conformal Killing horizons and their thermodynamics

    Science.gov (United States)

    Nielsen, Alex B.; Shoom, Andrey A.

    2018-05-01

    Certain dynamical black hole solutions can be mapped to static spacetimes by conformal metric transformations. This mapping provides a physical link between the conformal Killing horizon of the dynamical black hole and the Killing horizon of the static spacetime. Using the Vaidya spacetime as an example, we show how this conformal relation can be used to derive thermodynamic properties of such dynamical black holes. Although these horizons are defined quasi-locally and can be located by local experiments, they are distinct from other popular notions of quasi-local horizons such as apparent horizons. Thus in the dynamical Vaidya spacetime describing constant accretion of null dust, the conformal Killing horizon, which is null by construction, is the natural horizon to describe the black hole.

  9. Reciprocity Outperforms Conformity to Promote Cooperation.

    Science.gov (United States)

    Romano, Angelo; Balliet, Daniel

    2017-10-01

    Evolutionary psychologists have proposed two processes that could give rise to the pervasiveness of human cooperation observed among individuals who are not genetically related: reciprocity and conformity. We tested whether reciprocity outperformed conformity in promoting cooperation, especially when these psychological processes would promote a different cooperative or noncooperative response. To do so, across three studies, we observed participants' cooperation with a partner after learning (a) that their partner had behaved cooperatively (or not) on several previous trials and (b) that their group members had behaved cooperatively (or not) on several previous trials with that same partner. Although we found that people both reciprocate and conform, reciprocity has a stronger influence on cooperation. Moreover, we found that conformity can be partly explained by a concern about one's reputation-a finding that supports a reciprocity framework.

  10. Social conformity despite individual preferences for distinctiveness.

    Science.gov (United States)

    Smaldino, Paul E; Epstein, Joshua M

    2015-03-01

    We demonstrate that individual behaviours directed at the attainment of distinctiveness can in fact produce complete social conformity. We thus offer an unexpected generative mechanism for this central social phenomenon. Specifically, we establish that agents who have fixed needs to be distinct and adapt their positions to achieve distinctiveness goals, can nevertheless self-organize to a limiting state of absolute conformity. This seemingly paradoxical result is deduced formally from a small number of natural assumptions and is then explored at length computationally. Interesting departures from this conformity equilibrium are also possible, including divergence in positions. The effect of extremist minorities on these dynamics is discussed. A simple extension is then introduced, which allows the model to generate and maintain social diversity, including multimodal distinctiveness distributions. The paper contributes formal definitions, analytical deductions and counterintuitive findings to the literature on individual distinctiveness and social conformity.

  11. General Information for Transportation and Conformity

    Science.gov (United States)

    Transportation conformity is required by the Clean Air Act section 176(c) (42 U.S.C. 7506(c)) to ensure that federal funding and approval are given to highway and transit projects that are consistent with SIP.

  12. Film dosimetry in conformal radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Danciu, C; Proimos, B S [Patras Univ. (Greece). Dept. of Medical Physics

    1995-12-01

    Dosimetry, through a film sandwiched in a transverse cross-section of a solid phantom, is a method of choice in Conformal Radiotherapy because: (a) the blackness (density) of the film at each point offers a measure of the total dose received at that point, and (b) the film is easily calibrated by exposing a film strip in the same cross-section, through a stationary field. The film must therefore have the following properties: (a) it must be slow, in order not to be overexposed, even at a therapeutic dose of 200 cGy, and (b) the response of the film (density versus dose curve) must be independent of the photon energy spectrum. A few slow films were compared. It was found that the Kodak X-Omat V for therapy verification was the best choice. To investigate whether the film response was independent of the photon energy, response curves for six depths, starting from the depth of maximum dose to the depth of 25 cm, in solid phantom were derived. The vertical beam was perpendicular to the anterior surface of the phantom, which was at the distance of 100 cm from the source and the field was 15x15 cm at that distance. This procedure was repeated for photon beams emitted by a Cobalt-60 unit, two 6 MV and 15 MV Linear Accelerators, as well as a 45 MV Betatron. For each of those four different beams the film response was the same for all six depths. The results, as shown in the diagrams, are very satisfactory. The response curve under a geometry similar to that actually applied, when the film is irradiated in a transverse cross-section of the phantom, was derived. The horizontal beam was almost parallel (angle of 85) to the plane of the film. The same was repeated with the central ray parallel to the film (angle 90) and at a distance of 1.5 cm from the horizontal film. The field size was again 15x15 at the lateral entrance surface of the beam. The response curves remained the same, as when the beam was perpendicular to the films.

  13. Z/NZ conformal field theories

    International Nuclear Information System (INIS)

    Degiovanni, P.

    1990-01-01

    We compute the modular properties of the possible genus-one characters of some Rational Conformal Field Theories starting from their fusion rules. We show that the possible choices of S matrices are indexed by some automorphisms of the fusion algebra. We also classify the modular invariant partition functions of these theories. This gives the complete list of modular invariant partition functions of Rational Conformal Field Theories with respect to the A N (1) level one algebra. (orig.)

  14. Analytic aspects of rational conformal field theories

    International Nuclear Information System (INIS)

    Kiritsis, E.B.; Lawrence Berkeley Lab., CA

    1990-01-01

    The problem of deriving linear differential equations for correlation functions of Rational Conformal Field Theories is considered. Techniques from the theory of fuchsian differential equations are used to show that knowledge of the central charge, dimensions of primary fields and fusion rules are enough to fix the differential equations for one- and two-point functions on the tours. Any other correlation function can be calculated along similar lines. The results settle the issue of 'exact solution' of rational conformal field theories. (orig.)

  15. Virtual and solution conformations of oligosaccharides

    International Nuclear Information System (INIS)

    Cumming, D.A.; Carver, J.P.

    1987-01-01

    The possibility that observed nuclear Overhauser enhancements and bulk longitudinal relaxation times, parameters measured by 1 H NMR and often employed in determining the preferred solution conformation of biologically important molecules, are the result of averaging over many conformational states is quantitatively evaluated. Of particular interest was to ascertain whether certain 1 H NMR determined conformations are virtual in nature; i.e., the fraction of the population of molecules actually found at any time within the subset of conformational space defined as the solution conformation is vanishingly small. A statistical mechanics approach was utilized to calculate an ensemble average relaxation matrix from which (NOE)'s and (T 1 )'s are calculated. Model glycosidic linkages in four oligosaccharides were studied. The nature of the resultant population distributions is such that 50% of the molecular population is found within 1% of available microstates, while 99% of the molecular population occupies about 10% of the ensemble microstates, a number roughly equal to that sterically allowed. From this analysis the authors conclude that in many cases quantitative interpretation of NMR relaxation data, which attempts to define a single set of allowable torsion angle values consistent with the observed data, will lead to solution conformations that are either virtual or reflect torsion angle values possessed by a minority of the molecular population. Observed values of NMR relaxation data are the result of the complex interdependence of the population distribution and NOE (or T 1 ) surfaces in conformational space. In conformational analyses, NMR data can therefore be used to test different population distributions calculated from empirical potential energy functions

  16. Effective Conformal Descriptions of Black Hole Entropy

    Directory of Open Access Journals (Sweden)

    Steven Carlip

    2011-07-01

    Full Text Available It is no longer considered surprising that black holes have temperatures and entropies. What remains surprising, though, is the universality of these thermodynamic properties: their exceptionally simple and general form, and the fact that they can be derived from many very different descriptions of the underlying microscopic degrees of freedom. I review the proposal that this universality arises from an approximate conformal symmetry, which permits an effective “conformal dual” description that is largely independent of the microscopic details.

  17. On the Conformable Fractional Quantum Mechanics

    Science.gov (United States)

    Mozaffari, F. S.; Hassanabadi, H.; Sobhani, H.; Chung, W. S.

    2018-05-01

    In this paper, a conformable fractional quantum mechanic has been introduced using three postulates. Then in such a formalism, Schr¨odinger equation, probability density, probability flux and continuity equation have been derived. As an application of considered formalism, a fractional-radial harmonic oscillator has been considered. After obtaining its wave function and energy spectrum, effects of the conformable fractional parameter on some quantities have been investigated and plotted for different excited states.

  18. 94: Treatment plan optimization for conformal therapy

    International Nuclear Information System (INIS)

    Rosen, I.I.; Lane, R.G.

    1987-01-01

    Computer-controlled conformal radiation therapy techniques can deliver complex treatments utilizing large numbers of beams, gantry angles and beam shapes. Linear programming is well-suited for planning conformal treatments. Given a list of available treatment beams, linear programming calculates the relative weights of the beams such that the objective function is optimized and doses to constraint points are within the prescribed limits. 5 refs.; 3 figs

  19. Testing conformal mapping with kitchen aluminum foil

    OpenAIRE

    Haas, S.; Cooke, D. A.; Crivelli, P.

    2016-01-01

    We report an experimental verification of conformal mapping with kitchen aluminum foil. This experiment can be reproduced in any laboratory by undergraduate students and it is therefore an ideal experiment to introduce the concept of conformal mapping. The original problem was the distribution of the electric potential in a very long plate. The correct theoretical prediction was recently derived by A. Czarnecki (Can. J. Phys. 92, 1297 (2014)).

  20. Conformal (WEYL) invariance and Higgs mechanism

    International Nuclear Information System (INIS)

    Zhao Shucheng.

    1991-10-01

    A massive Yang-Mills field theory with conformal invariance and gauge invariance is proposed. It involves gravitational and various gauge interactions, in which all the mass terms appear as a uniform form of interaction m(x) KΦ(x). When the conformal symmetry is broken spontaneously and gravitation is ignored, the Higgs field emerges naturally, where the imaginary mass μ can be described as a background curvature. (author). 7 refs

  1. Efetivação do enquadramento de corpos d’água para fins de consumo humano em regiões semiáridas: Avaliação conforme resolução CONAMA 357/2005 e portaria MS 2914/2011

    Directory of Open Access Journals (Sweden)

    Zuri Bao Pessôa

    2015-12-01

    Full Text Available A escassez hídrica é situação recorrente em regiões de clima semiárido devido às condições climáticas naturais e à crescente pressão antrópica, através do lançamento direto ou indireto de cargas poluentes nas calhas dos rios. Para destinação da água ao consumo humano, uso prioritário em momentos de escassez, a Resolução CONAMA 357/05 estabelece que a água deve apresentar minimamente qualidade equivalente à classe 03, na hipótese de águas doces, ou compatível com classe 01, em se tratando de águas salobras. A Portaria 2.914/11 do Ministério da Saúde estabelece o padrão de potabilidade da água, ou seja, atendendo-se aos valores definidos na Portaria MS 2914/11 a água pode ser prontamente consumida. De acordo com a Resolução CONAMA 357/05, por sua vez, mesmo nas classes com possibilidade de abastecimento humano, a água deve ser submetida a processo de tratamento. Ainda assim, a Resolução CONAMA 357/05 é, para determinados parâmetros, mais restritiva que a Portaria MS 2914/11, o que pode ser associado ao fato de que os padrões definidos devem atender a todos os usos para os quais as classes são destinadas, além do abastecimento humano. Resta evidente, portanto, que é necessário reavaliar o critério de enquadramento de corpos hídricos, principalmente em situações de escassez hídrica. Esse trabalho tem como objetivo comparar a possibilidade de destinação de corpos hídricos para abastecimento humano após a aplicação de ações de saneamento básico considerando a Resolução CONAMA 357/05 isoladamente e em conjunto com a Portaria MS 2914/11. Como área de estudo utilizou-se trecho do baixo Salitre, rio principal da Bacia Hidrográfica do Salitre, inserida na região semiárida e sub-bacia da Bacia Hidrográfica do rio São Francisco. Após a identificação das fontes de poluição predominantes no trecho, selecionaram-se ações de saneamento básico para abatimento da carga poluidora afluente

  2. Conformal Symmetry as a Template for QCD

    Energy Technology Data Exchange (ETDEWEB)

    Brodsky, S

    2004-08-04

    Conformal symmetry is broken in physical QCD; nevertheless, one can use conformal symmetry as a template, systematically correcting for its nonzero {beta} function as well as higher-twist effects. For example, commensurate scale relations which relate QCD observables to each other, such as the generalized Crewther relation, have no renormalization scale or scheme ambiguity and retain a convergent perturbative structure which reflects the underlying conformal symmetry of the classical theory. The ''conformal correspondence principle'' also dictates the form of the expansion basis for hadronic distribution amplitudes. The AdS/CFT correspondence connecting superstring theory to superconformal gauge theory has important implications for hadron phenomenology in the conformal limit, including an all-orders demonstration of counting rules for hard exclusive processes as well as determining essential aspects of hadronic light-front wavefunctions. Theoretical and phenomenological evidence is now accumulating that QCD couplings based on physical observables such as {tau} decay become constant at small virtuality; i.e., effective charges develop an infrared fixed point in contradiction to the usual assumption of singular growth in the infrared. The near-constant behavior of effective couplings also suggests that QCD can be approximated as a conformal theory even at relatively small momentum transfer. The importance of using an analytic effective charge such as the pinch scheme for unifying the electroweak and strong couplings and forces is also emphasized.

  3. Rapid roll inflation with conformal coupling

    International Nuclear Information System (INIS)

    Kofman, Lev; Mukohyama, Shinji

    2008-01-01

    Usual inflation is realized with a slow rolling scalar field minimally coupled to gravity. In contrast, we consider dynamics of a scalar with a flat effective potential, conformally coupled to gravity. Surprisingly, it contains an attractor inflationary solution with the rapidly rolling inflaton field. We discuss models with the conformal inflaton with a flat potential (including hybrid inflation). There is no generation of cosmological fluctuations from the conformally coupled inflaton. We consider realizations of modulated (inhomogeneous reheating) or curvaton cosmological fluctuations in these models. We also implement these unusual features for the popular string-theoretic warped inflationary scenario, based on the interacting D3-D3 branes. The original warped brane inflation suffers a large inflaton mass due to conformal coupling to 4-dimensional gravity. Instead of considering this as a problem and trying to cure it with extra engineering, we show that warped inflation with the conformally coupled, rapidly rolling inflaton is yet possible with N=37 efoldings, which requires low-energy scales 1-100 TeV of inflation. Coincidentally, the same warping numerology can be responsible for the hierarchy. It is shown that the scalars associated with angular isometries of the warped geometry of compact manifold (e.g. S 3 of Klebanov-Strassler (KS) geometry) have solutions identical to conformally coupled modes and also cannot be responsible for cosmological fluctuations. We discuss other possibilities

  4. Rapid roll inflation with conformal coupling

    Science.gov (United States)

    Kofman, Lev; Mukohyama, Shinji

    2008-02-01

    Usual inflation is realized with a slow rolling scalar field minimally coupled to gravity. In contrast, we consider dynamics of a scalar with a flat effective potential, conformally coupled to gravity. Surprisingly, it contains an attractor inflationary solution with the rapidly rolling inflaton field. We discuss models with the conformal inflaton with a flat potential (including hybrid inflation). There is no generation of cosmological fluctuations from the conformally coupled inflaton. We consider realizations of modulated (inhomogeneous reheating) or curvaton cosmological fluctuations in these models. We also implement these unusual features for the popular string-theoretic warped inflationary scenario, based on the interacting D3-D¯3 branes. The original warped brane inflation suffers a large inflaton mass due to conformal coupling to 4-dimensional gravity. Instead of considering this as a problem and trying to cure it with extra engineering, we show that warped inflation with the conformally coupled, rapidly rolling inflaton is yet possible with N=37 efoldings, which requires low-energy scales 1 100 TeV of inflation. Coincidentally, the same warping numerology can be responsible for the hierarchy. It is shown that the scalars associated with angular isometries of the warped geometry of compact manifold (e.g. S3 of Klebanov-Strassler (KS) geometry) have solutions identical to conformally coupled modes and also cannot be responsible for cosmological fluctuations. We discuss other possibilities.

  5. Conformal field theories and tensor categories. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Bai, Chengming [Nankai Univ., Tianjin (China). Chern Institute of Mathematics; Fuchs, Juergen [Karlstad Univ. (Sweden). Theoretical Physics; Huang, Yi-Zhi [Rutgers Univ., Piscataway, NJ (United States). Dept. of Mathematics; Kong, Liang [Tsinghua Univ., Beijing (China). Inst. for Advanced Study; Runkel, Ingo; Schweigert, Christoph (eds.) [Hamburg Univ. (Germany). Dept. of Mathematics

    2014-08-01

    First book devoted completely to the mathematics of conformal field theories, tensor categories and their applications. Contributors include both mathematicians and physicists. Some long expository articles are especially suitable for beginners. The present volume is a collection of seven papers that are either based on the talks presented at the workshop ''Conformal field theories and tensor categories'' held June 13 to June 17, 2011 at the Beijing International Center for Mathematical Research, Peking University, or are extensions of the material presented in the talks at the workshop. These papers present new developments beyond rational conformal field theories and modular tensor categories and new applications in mathematics and physics. The topics covered include tensor categories from representation categories of Hopf algebras, applications of conformal field theories and tensor categories to topological phases and gapped systems, logarithmic conformal field theories and the corresponding non-semisimple tensor categories, and new developments in the representation theory of vertex operator algebras. Some of the papers contain detailed introductory material that is helpful for graduate students and researchers looking for an introduction to these research directions. The papers also discuss exciting recent developments in the area of conformal field theories, tensor categories and their applications and will be extremely useful for researchers working in these areas.

  6. Conformal field theories and tensor categories. Proceedings

    International Nuclear Information System (INIS)

    Bai, Chengming; Fuchs, Juergen; Huang, Yi-Zhi; Kong, Liang; Runkel, Ingo; Schweigert, Christoph

    2014-01-01

    First book devoted completely to the mathematics of conformal field theories, tensor categories and their applications. Contributors include both mathematicians and physicists. Some long expository articles are especially suitable for beginners. The present volume is a collection of seven papers that are either based on the talks presented at the workshop ''Conformal field theories and tensor categories'' held June 13 to June 17, 2011 at the Beijing International Center for Mathematical Research, Peking University, or are extensions of the material presented in the talks at the workshop. These papers present new developments beyond rational conformal field theories and modular tensor categories and new applications in mathematics and physics. The topics covered include tensor categories from representation categories of Hopf algebras, applications of conformal field theories and tensor categories to topological phases and gapped systems, logarithmic conformal field theories and the corresponding non-semisimple tensor categories, and new developments in the representation theory of vertex operator algebras. Some of the papers contain detailed introductory material that is helpful for graduate students and researchers looking for an introduction to these research directions. The papers also discuss exciting recent developments in the area of conformal field theories, tensor categories and their applications and will be extremely useful for researchers working in these areas.

  7. Universal hydrodynamics of non-conformal branes

    International Nuclear Information System (INIS)

    Kanitscheider, Ingmar; Skenderis, Kostas

    2009-01-01

    We examine the hydrodynamic limit of non-conformal branes using the recently developed precise holographic dictionary. We first streamline the discussion of holography for backgrounds that asymptote locally to non-conformal brane solutions by showing that all such solutions can be obtained from higher dimensional asymptotically locally AdS solutions by suitable dimensional reduction and continuation in the dimension. As a consequence, many holographic results for such backgrounds follow from the corresponding results of the Asymptotically AdS case. In particular, the hydrodynamics of non-conformal branes is fully determined in terms of conformal hydrodynamics. Using previous results on the latter we predict the form of the non-conformal hydrodynamic stress tensor to second order in derivatives. Furthermore we show that the ratio between bulk and shear viscosity is fixed by the generalized conformal structure to be ζ/η = 2(1/(d-1)-c s 2 ), where c s is the speed of sound in the fluid.

  8. Conformal Symmetry as a Template for QCD

    International Nuclear Information System (INIS)

    Brodsky, S

    2004-01-01

    Conformal symmetry is broken in physical QCD; nevertheless, one can use conformal symmetry as a template, systematically correcting for its nonzero β function as well as higher-twist effects. For example, commensurate scale relations which relate QCD observables to each other, such as the generalized Crewther relation, have no renormalization scale or scheme ambiguity and retain a convergent perturbative structure which reflects the underlying conformal symmetry of the classical theory. The ''conformal correspondence principle'' also dictates the form of the expansion basis for hadronic distribution amplitudes. The AdS/CFT correspondence connecting superstring theory to superconformal gauge theory has important implications for hadron phenomenology in the conformal limit, including an all-orders demonstration of counting rules for hard exclusive processes as well as determining essential aspects of hadronic light-front wavefunctions. Theoretical and phenomenological evidence is now accumulating that QCD couplings based on physical observables such as τ decay become constant at small virtuality; i.e., effective charges develop an infrared fixed point in contradiction to the usual assumption of singular growth in the infrared. The near-constant behavior of effective couplings also suggests that QCD can be approximated as a conformal theory even at relatively small momentum transfer. The importance of using an analytic effective charge such as the pinch scheme for unifying the electroweak and strong couplings and forces is also emphasized

  9. Analysis of the perception of risk of radiotherapy services in the metropolitan region of Rio de Janeiro using the risk evaluation system in radiotherapy (SEVRRA / FORUM); Analise da percepcao de risco de servicos de radioterapia da regiao metropolitana do Rio de Janeiro usando o sistema de avaliacao de risco em radioterapia (SEVRRA/FORO)

    Energy Technology Data Exchange (ETDEWEB)

    Burgos, Adam de Freitas

    2015-07-01

    In this work it was possible to analyze the perception of risks associated with existing processes in the high-dose rate brachytherapy and teletherapy using linear accelerators of radiotherapy services in the metropolitan area of Rio de Janeiro, through the combined use of two proposed methods: FMECA and risk matrix, using a general analysis and other more specific ones. The database software (SEVRRA) was used to identify possible existing processes in radiotherapy services (brachytherapy and teletherapy) and to classify the sequence of events in risk levels. The risk levels were analyzed at each stage and sub-stage, present in the treatment of patients undergoing high dose rate gynecological intracavitary brachytherapy and teletherapy treatments with the use of linear accelerators applying electron or photon beams in order to establish recommendations to the risks of highest priority for each case. The results show that although the procedure of high dose rate brachytherapy be automated and less susceptible to errors or failures, daily, one can still find considerable amounts of processes with worrying levels of risk perception. The processes that are more subject to radiological accident risks was associated with procedures, for of which the majority of the failures record and planning step of the treatment. The controls analyzed showed low efficiency, warning of the need to seek and implement new more efficient controls in routine brachytherapy for each participant service. About teletherapy procedure it was found that most of the failures were related to the registration and planning of treatment and equipment stages. The controls analyzed to teletherapy showed a poor result with a first type of analysis performed by suggesting a new type of more appropriate analysis. With a second type of analysis, these controls could be better analyzed and showed an order of importance according to a percentage of efficiency. Controls such as 'Double-check', 'Weekly image portal' and 'Weekly medical review of patients', were highlighted as the most present and effective in routine radiotherapy procedure. These results have great relevance for this type of methodology, since their practical application, together with its potential risk identification and classification, confirm their feasibility of use in routine services in the metropolitan area of Rio de Janeiro, as well as in other locations, seeking to meet national and international recommendations for safety and radiation protection. (author)

  10. Qualitative risk analysis in the process of treatment in radiation oncology for the steps performed by the technician/technologist in intensity modulated radiotherapy (lMRT); Analise qualitativa do risco no processo de tratamento em radioterapia para as etapas executadas pelo tecnico/tecnologo na radioterapia de intensidade modulada (lMRT)

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, Flavia C.S., E-mail: flavia@cnen.gov.br [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Faria, Alessandra L.; Pereira, Danielle P.S.; Silva, Fabiana M.I. [Universidade UNIGRANRIO, Duque de Caxias, RJ (Brazil)

    2013-10-01

    The efficacy of radiation therapy is to eradicate the tumor while preserving the integrity of normal tissues. Technological advances have allowed to develop techniques capable of modulating doses delivered to the target volume, providing more effective treatments. However, the operational complexity of these techniques makes the benefits offered are directly proportional to the chances of occurrences of serious errors. The objective of this work is to analyze the steps performed by the technician/technologist in Intensity Modulated Radiotherapy (IMRT), to detect possible errors in order to determine ways to mitigate them. After literature regarding errors in the radiation therapy, a prospective analysis was performed in the first half of 2012 in a radiation clinic located in the city of Rio de Janeiro, in which 11 technicians/technologists contributed to the survey data analysis. The method of risk analysis Failure Mode and Effects Analysis was used for prospective analysis of accidents/incidents, with respect to a qualitative assessment . The method allowed mapping 16 steps performed by technicians/technologists in the treatments with IMRT, identifying possible failures and their causes allowing to find ways to avoid possible errors. This analysis helped to confirm that the qualification and continuing education of technicians/technologists, allied to implement quality assurance programs and a computerized management can make a tool capable of IMRT to achieve the greatest challenge of radiotherapy. (author)

  11. Qualidade de vida de pacientes com câncer colorretal em terapia adjuvante Calidad de vida de pacientes con cáncer de rectocolon en terapia adyuvante Quality of life of patients with colorectal cancer who were receiving complementary therapy

    Directory of Open Access Journals (Sweden)

    Adriana Cristina Nicolussi

    2009-01-01

    Full Text Available OBJETIVO: Avaliar a qualidade de vida, identificar os domínios afetados nos pacientes com câncer colorretal, caracterizar os dados sócio-demográficos, clínicos e terapêuticos e correlacioná-los aos domínios da qualidade de vida. MÉTODOS: Estudo transversal, realizado no Centro Especializado de Oncologia de Ribeirão Preto com 22 pacientes com câncer colorretal em terapia adjuvante, entre julho/ 2006 a setembro/ 2007. Utilizou-se o instrumento Quality of Life Core-30-Questionnaire. RESULTADOS: A qualidade de vida foi considerada satisfatória (média = 79,13. Os domínios mais afetados foram: Função Emocional e sintomas dor, insônia, fadiga. Nas correlações, as mulheres destacaram-se negativamente, apresentando piores escores nas Funções Emocional, Cognitiva e sintomas: dor, insônia, fadiga, constipação e perda de apetite. Os pacientes em radioterapia relataram mais dor e os assintomáticos à quimioterapia são os que obtiveram melhor qualidade de vida geral. CONCLUSÃO: A qualidade de vida foi satisfatória, relativamente pior nas mulheres, em radioterapia e que apresentaram efeitos colaterais da quimioterapia.OBJETIVO: Evaluar la calidad de vida, identificar los dominios afectados en los pacientes con cáncer de rectocolon, caracterizar los datos socio-demográficos, clínicos y terapéuticos y correlacionarlos a los dominios de la calidad de vida. MÉTODOS: Estudio transversal, realizado en el Centro Especializado de Oncología de Ribeirão Preto con 22 pacientes con cáncer de rectocolon en terapia adyuvante, entre julio/ 2006 a setiembre/ 2007. Se utilizó el instrumento Quality of Life Core-30-Questionnaire. RESULTADOS: La calidad de vida fue considerada satisfactoria (media = 79,13. Los dominios más afectados fueron: Función Emocional y síntomas dolor, insomnio, fatiga. En las correlaciones, las mujeres se destacaron negativamente, presentando peores escores en las Funciones Emocional, Cognitiva y síntomas: dolor

  12. Entre o conformismo e o sonho: percepções de mulheres em situação de vulnerabilidade social à luz das concepções de Amartya Sen Between conformism and dreams: perceptions of women in social vulnerability situations from the perspective of Amartya Sen

    Directory of Open Access Journals (Sweden)

    Kelly Alves Magalhães

    2011-12-01

    Full Text Available O estudo objetivou analisar a percepção de mulheres em situação de vulnerabilidade social, sobre seus sonhos e as formas de enfrentamento das adversidades presentes em seu cotidiano, buscando perceber como a situação de pobreza, segundo as concepções de Amartya Sen, interferiam em sua atitude perante a vida. Trata-se de um estudo qualitativo, realizado em agosto e setembro de 2007, no município de Paula Cândido-MG. Foram entrevistadas 110 mulheres (10% cadastradas no Programa Bolsa Família, selecionadas aleatoriamente. Os dados foram coletados por meio de questionário semiestruturado e analisados por meio da técnica de análise temática. Verificou-se que o desejo por uma "vida melhor" foi, em última instância, o maior sonho das mulheres entrevistadas, sendo o conjunto "educação-trabalho-dinheiro" o meio mais citado para se alcançar uma vida digna. Contudo, a baixa escolaridade, o trabalho precário e informal e a má remuneração constituíram obstáculos à realização de seus sonhos. Diante de tais adversidades, a atitude das entrevistadas variou desde o conformismo e desesperança até o autorreconhecimento de sua situação como sujeito no mundo, capaz de sonhar e acreditar na possibilidade de realização de suas aspirações, utilizando suas habilidades e recursos para lutar por uma "vida melhor". Ressalta-se que uma política de combate à pobreza - como o PBF - deve buscar a expansão das capacidades humanas, articulando-se com ações estruturais, a fim de atingir o objetivo último do referido programa: a emancipação sustentada das famílias beneficiadas e sua inclusão social.The study aimed to analyze the perception of women in situations of social vulnerability, about their dreams and ways of coping with adversities in their daily lives, trying to see how poverty, according to the concepts of Amartya Sen, interfered in their attitude towards life. It is a qualitative study, conducted in August and September

  13. Application of Conformational Space Search in Drug Action | Adikwu ...

    African Journals Online (AJOL)

    The role of conformational space in drug action is presented. Two examples of molecules in different therapeutic groups are presented. Conformational space search will lead to isolating the exact conformation with the desired medicinal properties. Many conformations of a plant isolate may exist which are active, weakly ...

  14. 47 CFR 2.906 - Declaration of Conformity.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Declaration of Conformity. 2.906 Section 2.906... Conformity. (a) A Declaration of Conformity is a procedure where the responsible party, as defined in § 2.909... of Conformity attaches to all items subsequently marketed by the responsible party which are...

  15. 40 CFR 91.106 - Certificate of conformity.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Certificate of conformity. 91.106... Provisions § 91.106 Certificate of conformity. (a) Every manufacturer of a new marine SI engine produced... obtain a certificate of conformity covering each engine family. The certificate of conformity must be...

  16. 47 CFR 68.320 - Supplier's Declaration of Conformity.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Supplier's Declaration of Conformity. 68.320... Approval § 68.320 Supplier's Declaration of Conformity. (a) Supplier's Declaration of Conformity is a... Supplier's Declaration of Conformity attaches to all items subsequently marketed by the responsible party...

  17. 21 CFR 26.70 - Conformity assessment bodies.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Conformity assessment bodies. 26.70 Section 26.70...Frameworkâ Provisions § 26.70 Conformity assessment bodies. Each party recognizes that the conformity... conformity in relation to its requirements as specified in subpart B of this part. The parties shall specify...

  18. A note on fashion cycles, novelty and conformity

    OpenAIRE

    Federica Alberti

    2013-01-01

    We develop a model in which novelty and conformity motivate fashion behavior. Fashion cycles occur if conformity is not too high. The duration of fashion cycles depends on individual-specific conformity, novelty, and the number of available styles. The use of individual-specific novelty and conformity allows us to also identify fashion leaders.

  19. Neonatal Phosphate Nutrition Alters <em>in em>Vivo> and <em>in em>Vitro> Satellite Cell Activity in Pigs

    Directory of Open Access Journals (Sweden)

    Chad H. Stahl

    2012-05-01

    Full Text Available Satellite cell activity is necessary for postnatal skeletal muscle growth. Severe phosphate (PO4 deficiency can alter satellite cell activity, however the role of neonatal PO4 nutrition on satellite cell biology remains obscure. Twenty-one piglets (1 day of age, 1.8 ± 0.2 kg BW were pair-fed liquid diets that were either PO4 adequate (0.9% total P, supra-adequate (1.2% total P in PO4 requirement or deficient (0.7% total P in PO4 content for 12 days. Body weight was recorded daily and blood samples collected every 6 days. At day 12, pigs were orally dosed with BrdU and 12 h later, satellite cells were isolated. Satellite cells were also cultured <em>in vitroem> for 7 days to determine if PO4 nutrition alters their ability to proceed through their myogenic lineage. Dietary PO4 deficiency resulted in reduced (<em>P> < 0.05 sera PO4 and parathyroid hormone (PTH concentrations, while supra-adequate dietary PO4 improved (<em>P> < 0.05 feed conversion efficiency as compared to the PO4 adequate group. <em>In vivoem> satellite cell proliferation was reduced (<em>P> < 0.05 among the PO4 deficient pigs, and these cells had altered <em>in vitroem> expression of markers of myogenic progression. Further work to better understand early nutritional programming of satellite cells and the potential benefits of emphasizing early PO4 nutrition for future lean growth potential is warranted.

  20. Conformal anomaly of super Wilson loop

    Energy Technology Data Exchange (ETDEWEB)

    Belitsky, A.V., E-mail: andrei.belitsky@asu.edu [Department of Physics, Arizona State University, Tempe, AZ 85287-1504 (United States)

    2012-09-11

    Classically supersymmetric Wilson loop on a null polygonal contour possesses all symmetries required to match it onto non-MHV amplitudes in maximally supersymmetric Yang-Mills theory. However, to define it quantum mechanically, one is forced to regularize it since perturbative loop diagrams are not well defined due to presence of ultraviolet divergences stemming from integration in the vicinity of the cusps. A regularization that is adopted by practitioners by allowing one to use spinor helicity formalism, on the one hand, and systematically go to higher orders of perturbation theory is based on a version of dimensional regularization, known as Four-Dimensional Helicity scheme. Recently it was demonstrated that its use for the super Wilson loop at one loop breaks both conformal symmetry and Poincare supersymmetry. Presently, we exhibit the origin for these effects and demonstrate how one can undo this breaking. The phenomenon is alike the one emerging in renormalization group mixing of conformal operators in conformal theories when one uses dimensional regularization. The rotation matrix to the diagonal basis is found by means of computing the anomaly in the Ward identity for the conformal boost. Presently, we apply this ideology to the super Wilson loop. We compute the one-loop conformal anomaly for the super Wilson loop and find that the anomaly depends on its Grassmann coordinates. By subtracting this anomalous contribution from the super Wilson loop we restore its interpretation as a dual description for reduced non-MHV amplitudes which are expressed in terms of superconformal invariants.

  1. Seed conformal blocks in 4D CFT

    Energy Technology Data Exchange (ETDEWEB)

    Echeverri, Alejandro Castedo; Elkhidir, Emtinan; Karateev, Denis [SISSA and INFN,Via Bonomea 265, I-34136 Trieste (Italy); Serone, Marco [SISSA and INFN,Via Bonomea 265, I-34136 Trieste (Italy); ICTP,Strada Costiera 11, I-34151 Trieste (Italy)

    2016-02-29

    We compute in closed analytical form the minimal set of “seed' conformal blocks associated to the exchange of generic mixed symmetry spinor/tensor operators in an arbitrary representation (ℓ,ℓ̄) of the Lorentz group in four dimensional conformal field theories. These blocks arise from 4-point functions involving two scalars, one (0,|ℓ−ℓ̄|) and one (|ℓ−ℓ̄|,0) spinors or tensors. We directly solve the set of Casimir equations, that can elegantly be written in a compact form for any (ℓ,ℓ̄), by using an educated ansatz and reducing the problem to an algebraic linear system. Various details on the form of the ansatz have been deduced by using the so called shadow formalism. The complexity of the conformal blocks depends on the value of p=|ℓ−ℓ̄| and grows with p, in analogy to what happens to scalar conformal blocks in d even space-time dimensions as d increases. These results open the way to bootstrap 4-point functions involving arbitrary spinor/tensor operators in four dimensional conformal field theories.

  2. Riesgo familiar total en familias con escolares según rendimiento académico Risco familiar total em famílias com escolares conforme aproveitamento acadêmico Total family risk in families with schoolchildren according to academic performance

    Directory of Open Access Journals (Sweden)

    CAROLINA LUCERO ENRÍQUEZ GUERRERO

    Full Text Available Este artículo presenta los resultados del estudio cuyo objetivo fue establecer las diferencias en el riesgo familiar entre dos grupos de familias: con niños escolares de alto rendimiento y niños de bajo rendimiento académico en un centro educativo distrital de Bogotá. Metodología: estudio descriptivo comparativo transversal con un componente analítico y abordaje cuantitativo; la muestra fue de 186 familias, durante abril a julio de 2007. Los resultados muestran predominio de familias nucleares en ambos grupos (65%, relación inversa entre el riesgo familiar total evaluado por el instrumento RFT 7-70 y el rendimiento académico del escolar de la familia, es decir que las familias que registraron riesgo alto (9% y medio (31% en mayor proporción son familias con escolares de bajo rendimiento académico, frente al predominio del riesgo familiar bajo (78% en las familias con niños de alto rendimiento. Se aplicó t de student para diferencia de medias y se encontró asociación (P = 0,02 entre el riesgo familiar total alto y el bajo rendimiento académico del escolar. En conclusión, estos resultados sugieren principalmente que se deben priorizar los factores de riesgo que determinan mayor riesgo familiar en familias con escolares de bajo rendimiento académico y dar atención de salud integral con enfoque familiar e intersectorial, y participación activa de la comunidad. Continuar investigando en posibles asociaciones entre salud individual, prácticas de salud, educación, ambiente socioeconómico y psicoafectivo de la familia y el logro educativo de escolares en familias con niños en edad escolar.Este artigo apresenta os resultados de um levantamento que objetiva estabelecer as diferenças no risco familiar entre dois grupos de famílias: com crianças escolares de alto aproveitamento acadêmico e crianças escolares de baixo aproveitamento acadêmico em um centro educativo distrital de Bogotá. Metodologia: levantamento descritivo

  3. Riesgo familiar total en familias con escolares según rendimiento académico Total family risk in families with schoolchildren according to academic performance Risco familiar total em famílias com escolares conforme aproveitamento acadêmico

    Directory of Open Access Journals (Sweden)

    CATAÑO ORDÓÑEZ NHORA

    2009-12-01

    analytic component and a quantitative approach; the sample was 186 families during the period April-July 2007. The results show a predominance of nuclear families in both groups (65%, reverse relation between the family risk evaluated by the RFT 7-70 instrument and the academic performance of the family´s schoolchild, that is to say that the families that recorded a high risk (9% and average risk (31% are, to a large extent, families with schoolchildren that show low academic performance, in respect of the predominance of low family risk (78% in families with children that show high academic performance. The t of student was applied to differentiate averages and association was found (P = 0,02 between the total high family risk and the low academic performance of the schoolchild. In conclusion, these results suggest mainly that risk factors that determine higher family risk in families with schoolchildren who show low academic performance must be prioritized and that integral healthcare must be provided with a family and intersectorial approach as well as active participation from the community. Continue research activities in possible associations between individual health, health practice, and education, socio-economic and psycho-affective environment of the family and academic achievement of schoolchildren in families with school age children.Este artigo apresenta os resultados de um levantamento que objetiva estabelecer as diferenças no risco familiar entre dois grupos de famílias: com crianças escolares de alto aproveitamento acadêmico e crianças escolares de baixo aproveitamento acadêmico em um centro educativo distrital de Bogotá. Metodologia: levantamento descritivo comparativo transversal com um componente analítico e abordagem quantitativa; a amostra foi de 186 famílias, durante abril - julho de 2007. Os resultados apresentam predomínio de famílias nucleares em ambos os grupos (65%, relação inversa entre o risco familiar total avaliado pelo

  4. SCit: web tools for protein side chain conformation analysis.

    Science.gov (United States)

    Gautier, R; Camproux, A-C; Tufféry, P

    2004-07-01

    SCit is a web server providing services for protein side chain conformation analysis and side chain positioning. Specific services use the dependence of the side chain conformations on the local backbone conformation, which is described using a structural alphabet that describes the conformation of fragments of four-residue length in a limited library of structural prototypes. Based on this concept, SCit uses sets of rotameric conformations dependent on the local backbone conformation of each protein for side chain positioning and the identification of side chains with unlikely conformations. The SCit web server is accessible at http://bioserv.rpbs.jussieu.fr/SCit.

  5. The conformal method and the conformal thin-sandwich method are the same

    International Nuclear Information System (INIS)

    Maxwell, David

    2014-01-01

    The conformal method developed in the 1970s and the more recent Lagrangian and Hamiltonian conformal thin-sandwich methods are techniques for finding solutions of the Einstein constraint equations. We show that they are manifestations of a single conformal method: there is a straightforward way to convert back and forth between the parameters for these methods so that the corresponding solutions of the Einstein constraint equations agree. The unifying idea is the need to clearly distinguish tangent and cotangent vectors to the space of conformal classes on a manifold, and we introduce a vocabulary for working with these objects without reference to a particular representative background metric. As a consequence of these conceptual advantages, we demonstrate how to strengthen previous near-CMC (constant mean curvature) existence and non-existence theorems for the original conformal method to include metrics with scalar curvatures that change sign. (paper)

  6. S-Adenosylmethionine conformations in solution and in protein complexes: Conformational influences of the sulfonium group

    DEFF Research Database (Denmark)

    Markham, George D.; Norrby, Per-Ola; Bock, Charles W.

    2002-01-01

    S-Adenosylmethionine (AdoMet) and other sulfonium ions play central roles in the metabolism of all organisms. The conformational preferences of AdoMet and two other biologically important sulfonium ions, S-methylmethionine and dimethylsulfonioproprionic acid, have been investigated by NMR...... and computational studies. Molecular mechanics parameters for the sulfonium center have been developed for the AMBER force field to permit analysis of NMR results and to enable comparison of the relative energies of the different conformations of AdoMet that have been found in crystal structures of complexes...... with proteins. S-Methylmethionine and S-dimethylsulfonioproprionate adopt a variety of conformations in aqueous solution; a conformation with an electrostatic interaction between the sulfonium sulfur and the carboxylate group is not noticeably favored, in contrast to the preferred conformation found by in vacuo...

  7. Constituents from <em>Vigna em>vexillata> and Their Anti-Inflammatory Activity

    Directory of Open Access Journals (Sweden)

    Guo-Feng Chen

    2012-08-01

    Full Text Available The seeds of <em>Vigna em>genus are important food resources and there have already been many reports regarding their bioactivities. In our preliminary bioassay, the chloroform layer of methanol extracts of<em> V. vexillata em>demonstrated significant anti-inflammatory bioactivity. Therefore, the present research is aimed to purify and identify the anti-inflammatory principles of <em>V. vexillataem>. One new sterol (1 and two new isoflavones (2,3 were reported from the natural sources for the first time and their chemical structures were determined by the spectroscopic and mass spectrometric analyses. In addition, 37 known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. Among the isolates, daidzein (23, abscisic acid (25, and quercetin (40 displayed the most significant inhibition of superoxide anion generation and elastase release.

  8. The conforming brain and deontological resolve.

    Science.gov (United States)

    Pincus, Melanie; LaViers, Lisa; Prietula, Michael J; Berns, Gregory

    2014-01-01

    Our personal values are subject to forces of social influence. Deontological resolve captures how strongly one relies on absolute rules of right and wrong in the representation of one's personal values and may predict willingness to modify one's values in the presence of social influence. Using fMRI, we found that a neurobiological metric for deontological resolve based on relative activity in the ventrolateral prefrontal cortex (VLPFC) during the passive processing of sacred values predicted individual differences in conformity. Individuals with stronger deontological resolve, as measured by greater VLPFC activity, displayed lower levels of conformity. We also tested whether responsiveness to social reward, as measured by ventral striatal activity during social feedback, predicted variability in conformist behavior across individuals but found no significant relationship. From these results we conclude that unwillingness to conform to others' values is associated with a strong neurobiological representation of social rules.

  9. Double-trace deformations of conformal correlations

    Science.gov (United States)

    Giombi, Simone; Kirilin, Vladimir; Perlmutter, Eric

    2018-02-01

    Large N conformal field theories often admit unitary renormalization group flows triggered by double-trace deformations. We compute the change in scalar four-point functions under double-trace flow, to leading order in 1/ N. This has a simple dual in AdS, where the flow is implemented by a change of boundary conditions, and provides a physical interpretation of single-valued conformal partial waves. We extract the change in the conformal dimensions and three-point coefficients of infinite families of double-trace composite operators. Some of these quantities are found to be sign-definite under double-trace flow. As an application, we derive anomalous dimensions of spinning double-trace operators comprised of non-singlet constituents in the O( N) vector model.

  10. Causality Constraints in Conformal Field Theory

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    Causality places nontrivial constraints on QFT in Lorentzian signature, for example fixing the signs of certain terms in the low energy Lagrangian. In d-dimensional conformal field theory, we show how such constraints are encoded in crossing symmetry of Euclidean correlators, and derive analogous constraints directly from the conformal bootstrap (analytically). The bootstrap setup is a Lorentzian four-point function corresponding to propagation through a shockwave. Crossing symmetry fixes the signs of certain log terms that appear in the conformal block expansion, which constrains the interactions of low-lying operators. As an application, we use the bootstrap to rederive the well known sign constraint on the (∂φ)4 coupling in effective field theory, from a dual CFT. We also find constraints on theories with higher spin conserved currents. Our analysis is restricted to scalar correlators, but we argue that similar methods should also impose nontrivial constraints on the interactions of spinni...

  11. Asymptotic mass degeneracies in conformal field theories

    International Nuclear Information System (INIS)

    Kani, I.; Vafa, C.

    1990-01-01

    By applying a method of Hardy and Ramanujan to characters of rational conformal field theories, we find an asymptotic expansion for degeneracy of states in the limit of large mass which is exact for strings propagating in more than two uncompactified space-time dimensions. Moreover we explore how the rationality of the conformal theory is reflected in the degeneracy of states. We also consider the one loop partition function for strings, restricted to physical states, for arbitrary (irrational) conformal theories, and obtain an asymptotic expansion for it in the limit that the torus degenerates. This expansion depends only on the spectrum of (physical and unphysical) relevant operators in the theory. We see how rationality is consistent with the smoothness of mass degeneracies as a function of moduli. (orig.)

  12. Hidden symmetries of integrable conformal mechanical systems

    International Nuclear Information System (INIS)

    Hakobyan, Tigran; Krivonos, Sergey; Lechtenfeld, Olaf; Nersessian, Armen

    2010-01-01

    We split the generic conformal mechanical system into a 'radial' and an 'angular' part, where the latter is defined as the Hamiltonian system on the orbit of the conformal group, with the Casimir function in the role of the Hamiltonian. We reduce the analysis of the constants of motion of the full system to the study of certain differential equations on this orbit. For integrable mechanical systems, the conformal invariance renders them superintegrable, yielding an additional series of conserved quantities originally found by Wojciechowski in the rational Calogero model. Finally, we show that, starting from any N=4 supersymmetric 'angular' Hamiltonian system one may construct a new system with full N=4 superconformal D(1,2;α) symmetry.

  13. The conforming brain and deontological resolve.

    Directory of Open Access Journals (Sweden)

    Melanie Pincus

    Full Text Available Our personal values are subject to forces of social influence. Deontological resolve captures how strongly one relies on absolute rules of right and wrong in the representation of one's personal values and may predict willingness to modify one's values in the presence of social influence. Using fMRI, we found that a neurobiological metric for deontological resolve based on relative activity in the ventrolateral prefrontal cortex (VLPFC during the passive processing of sacred values predicted individual differences in conformity. Individuals with stronger deontological resolve, as measured by greater VLPFC activity, displayed lower levels of conformity. We also tested whether responsiveness to social reward, as measured by ventral striatal activity during social feedback, predicted variability in conformist behavior across individuals but found no significant relationship. From these results we conclude that unwillingness to conform to others' values is associated with a strong neurobiological representation of social rules.

  14. An introduction to conformal field theory

    International Nuclear Information System (INIS)

    Gaberdiel, Matthias R.; Fitzwilliam College, Cambridge

    2000-01-01

    A comprehensive introduction to two-dimensional conformal field theory is given. The structure of the meromorphic subtheory is described in detail, and a number of examples are presented explicitly. Standard constructions such as the coset and the orbifold construction are explained. The concept of a representation of the meromorphic theory is introduced, and the role of Zhu's algebra in classifying highest weight representations is elucidated. The fusion product of two representations and the corresponding fusion rules are defined, and Verlinde's formula is explained. Finally, higher correlation functions are considered, and the polynomial relations of Moore and Seiberg and the quantum group structure of chiral conformal field theory are discussed. The treatment is relatively general and also allows for a description of less well known classes of theories such as logarithmic conformal field theories. (author)

  15. Coadjoint orbits and conformal field theory

    International Nuclear Information System (INIS)

    Taylor, W. IV.

    1993-08-01

    This thesis is primarily a study of certain aspects of the geometric and algebraic structure of coadjoint orbit representations of infinite-dimensional Lie groups. The goal of this work is to use coadjoint orbit representations to construct conformal field theories, in a fashion analogous to the free-field constructions of conformal field theories. The new results which are presented in this thesis are as follows: First, an explicit set of formulae are derived giving an algebraic realization of coadjoint orbit representations in terms of differential operators acting on a polynomial Fock space. These representations are equivalent to dual Verma module representations. Next, intertwiners are explicitly constructed which allow the construction of resolutions for irreducible representations using these Fock space realizations. Finally, vertex operators between these irreducible representations are explicitly constructed as chain maps between the resolutions; these vertex operators allow the construction of rational conformal field theories according to an algebraic prescription

  16. Conformal geometry computational algorithms and engineering applications

    CERN Document Server

    Jin, Miao; He, Ying; Wang, Yalin

    2018-01-01

    This book offers an essential overview of computational conformal geometry applied to fundamental problems in specific engineering fields. It introduces readers to conformal geometry theory and discusses implementation issues from an engineering perspective.  The respective chapters explore fundamental problems in specific fields of application, and detail how computational conformal geometric methods can be used to solve them in a theoretically elegant and computationally efficient way. The fields covered include computer graphics, computer vision, geometric modeling, medical imaging, and wireless sensor networks. Each chapter concludes with a summary of the material covered and suggestions for further reading, and numerous illustrations and computational algorithms complement the text.  The book draws on courses given by the authors at the University of Louisiana at Lafayette, the State University of New York at Stony Brook, and Tsinghua University, and will be of interest to senior undergraduates, gradua...

  17. Causality constraints in conformal field theory

    Energy Technology Data Exchange (ETDEWEB)

    Hartman, Thomas; Jain, Sachin; Kundu, Sandipan [Department of Physics, Cornell University,Ithaca, New York (United States)

    2016-05-17

    Causality places nontrivial constraints on QFT in Lorentzian signature, for example fixing the signs of certain terms in the low energy Lagrangian. In d dimensional conformal field theory, we show how such constraints are encoded in crossing symmetry of Euclidean correlators, and derive analogous constraints directly from the conformal bootstrap (analytically). The bootstrap setup is a Lorentzian four-point function corresponding to propagation through a shockwave. Crossing symmetry fixes the signs of certain log terms that appear in the conformal block expansion, which constrains the interactions of low-lying operators. As an application, we use the bootstrap to rederive the well known sign constraint on the (∂ϕ){sup 4} coupling in effective field theory, from a dual CFT. We also find constraints on theories with higher spin conserved currents. Our analysis is restricted to scalar correlators, but we argue that similar methods should also impose nontrivial constraints on the interactions of spinning operators.

  18. Conformal boundary state for the rectangular geometry

    Energy Technology Data Exchange (ETDEWEB)

    Bondesan, R., E-mail: roberto.bondesan@cea.fr [Institute de Physique Theorique, CEA Saclay, F-91191 Gif-sur-Yvette (France); LPTENS, Ecole Normale Superieure, 24 rue Lhomond, 75231 Paris (France); Institut Henri Poincare, 11 rue Pierre et Marie Curie, 75231 Paris (France); Dubail, J. [Department of Physics, Yale University, P.O. Box 208120, New Haven, CT 06520-8120 (United States); Jacobsen, J.L. [LPTENS, Ecole Normale Superieure, 24 rue Lhomond, 75231 Paris (France); Institut Henri Poincare, 11 rue Pierre et Marie Curie, 75231 Paris (France); Universite Pierre et Marie Curie, 4 place Jussieu, 75252 Paris (France); Saleur, H. [Institute de Physique Theorique, CEA Saclay, F-91191 Gif-sur-Yvette (France); Institut Henri Poincare, 11 rue Pierre et Marie Curie, 75231 Paris (France); Physics Department, USC, Los Angeles, CA 90089-0484 (United States)

    2012-09-11

    We discuss conformal field theories (CFTs) in rectangular geometries, and develop a formalism that involves a conformal boundary state for the 1+1d open system. We focus on the case of homogeneous boundary conditions (no insertion of a boundary condition changing operator), for which we derive an explicit expression of the associated boundary state, valid for any arbitrary CFT. We check the validity of our solution, comparing it with known results for partition functions, numerical simulations of lattice discretizations, and coherent state expressions for free theories.

  19. Theories of inflation and conformal transformations

    International Nuclear Information System (INIS)

    Kalara, S.; Kaloper, N.; Olive, K.A.

    1990-01-01

    We show that several different theories of inflation including R 2 , Brans-Dicke, and induced-gravity inflation are all related to generalized or power-law inflation by means of conformal transformations. These theories all involve non-standard gravity, and the use of conformal transformations allows one to obtain standard inflationary predictions such as the expansion time-scale, reheating and density perturbations in each case very simply. We also discuss the possibilities of this method to be applied to string theory. (orig.)

  20. Wilson loop invariants from WN conformal blocks

    Directory of Open Access Journals (Sweden)

    Oleg Alekseev

    2015-12-01

    Full Text Available Knot and link polynomials are topological invariants calculated from the expectation value of loop operators in topological field theories. In 3D Chern–Simons theory, these invariants can be found from crossing and braiding matrices of four-point conformal blocks of the boundary 2D CFT. We calculate crossing and braiding matrices for WN conformal blocks with one component in the fundamental representation and another component in a rectangular representation of SU(N, which can be used to obtain HOMFLY knot and link invariants for these cases. We also discuss how our approach can be generalized to invariants in higher-representations of WN algebra.

  1. Conformal pure radiation with parallel rays

    International Nuclear Information System (INIS)

    Leistner, Thomas; Paweł Nurowski

    2012-01-01

    We define pure radiation metrics with parallel rays to be n-dimensional pseudo-Riemannian metrics that admit a parallel null line bundle K and whose Ricci tensor vanishes on vectors that are orthogonal to K. We give necessary conditions in terms of the Weyl, Cotton and Bach tensors for a pseudo-Riemannian metric to be conformal to a pure radiation metric with parallel rays. Then, we derive conditions in terms of the tractor calculus that are equivalent to the existence of a pure radiation metric with parallel rays in a conformal class. We also give analogous results for n-dimensional pseudo-Riemannian pp-waves. (paper)

  2. Spherical conformal models for compact stars

    Energy Technology Data Exchange (ETDEWEB)

    Takisa, P.M.; Maharaj, S.D.; Manjonjo, A.M.; Moopanar, S. [University of KwaZulu-Natal, Astrophysics and Cosmology Research Unit, School of Mathematics, Statistics and Computer Science, Durban (South Africa)

    2017-10-15

    We consider spherical exact models for compact stars with anisotropic pressures and a conformal symmetry. The conformal symmetry condition generates an integral relationship between the gravitational potentials. We solve this condition to find a new anisotropic solution to the Einstein field equations. We demonstrate that the exact solution produces a relativistic model of a compact star. The model generates stellar radii and masses consistent with PSR J1614-2230, Vela X1, PSR J1903+327 and Cen X-3. A detailed physical examination shows that the model is regular, well behaved and stable. The mass-radius limit and the surface red shift are consistent with observational constraints. (orig.)

  3. Nilpotent weights in conformal field theory

    Directory of Open Access Journals (Sweden)

    S. Rouhani

    2001-12-01

    Full Text Available   Logarithmic conformal field theory can be obtained using nilpotent weights. Using such scale transformations various properties of the theory were derived. The derivation of four point function needs a knowledge of singular vectors which is derived by including nilpotent variables into the Kac determinant. This leads to inhomogeneous hypergeometric functions. Finally we consider the theory near a boundary and also introduce the concept of superfields where a multiplet of conformal fields are dealt with together. This leads to the OPE of superfields and a logarithmic partner for the energy momentum tensor.

  4. Conformal invariance in quantum field theory

    International Nuclear Information System (INIS)

    Grensing, G.

    1978-01-01

    We study the transformation law of interacting fields under the universal covering group of the conformal group. It is defined with respect to the representations of the discrete series. These representations are field representations in the sense that they act on finite component fields defined over Minkowski space. The conflict with Einstein causality is avoided as in the case of free fields with canonical dimension. Furthermore, we determine the conformal invariant two-point function of arbitrary spin. Our result coincides with that obtained by Ruehl. In particular, we investigate the two-point function of symmetric and traceless tensor fields and give the explicit form of the trace terms

  5. A Framework for Online Conformance Checking

    DEFF Research Database (Denmark)

    Burattin, Andrea; Carmona, Josep

    2017-01-01

    is quantified after the completion of the process instance. In this paper we propose a framework for online conformance checking: not only do we quantify (non-)conformant behavior as the execution is running, we also restrict the computation to constant time complexity per event analyzed, thus enabling...... the online analysis of a stream of events. The framework is instantiated with ideas coming from the theory of regions, and state similarity. An implementation is available in ProM and promising results have been obtained....

  6. Recent progress in irrational conformal field theory

    International Nuclear Information System (INIS)

    Halpern, M.B.

    1993-09-01

    In this talk, I will review the foundations of irrational conformal field theory (ICFT), which includes rational conformal field theory as a small subspace. Highlights of the review include the Virasoro master equation, the Ward identities for the correlators of ICFT and solutions of the Ward identities. In particular, I will discuss the solutions for the correlators of the g/h coset construction and the correlators of the affine-Sugawara nests on g contains h 1 contains hor-ellipsis contains h n . Finally, I will discuss the recent global solution for the correlators of all the ICFT's in the master equation

  7. Graded associative conformal algebras of finite type

    OpenAIRE

    Kolesnikov, Pavel

    2011-01-01

    In this paper, we consider graded associative conformal algebras. The class of these objects includes pseudo-algebras over non-cocommutative Hopf algebras of regular functions on some linear algebraic groups. In particular, an associative conformal algebra which is graded by a finite group $\\Gamma $ is a pseudo-algebra over the coordinate Hopf algebra of a linear algebraic group $G$ such that the identity component $G^0$ is the affine line and $G/G^0\\simeq \\Gamma $. A classification of simple...

  8. Momentos em freios e em embraiagens

    OpenAIRE

    Mimoso, Rui Miguel Pereira

    2011-01-01

    Dissertação para obtenção do Grau de Mestre em Mestrado Integrado em Engenharia Mecânica Nesta dissertação reúnem-se os modelos de cálculo utilizados na determinação dos momentos em freios e em embraiagens. Neste trabalho consideram-se os casos de freios e embraiagens de atrito seco e atrito viscoso. Nos freios de atrito viscoso são considerados casos em que as características dos fluidos não são induzidas, e outros em que são induzidas modificações a essas mesmas características. São a...

  9. Oxigenoterapia hiperbárica em lesões actínicas de colo de ratos: aspectos morfológicos e morfométricos Hiperbaric oxygen in actinic lesions of rat colon: morphological and morphometric aspects

    Directory of Open Access Journals (Sweden)

    Maria Ligia Lyra Pereira

    2004-12-01

    Full Text Available Objetivo: Avaliar a ação da oxigenação hiperbárica em lesões actínicas provocadas por radiação ionizante no colo distal de ratas. Métodos: Foram utilizadas 32 ratas adultas distribuídas em quatro grupos. I - sham; II - oxigenoterapia hiperbárica (OHT; III - radioterapia (RT, e IV - radioterapia e oxigenoterapia hiperbárica (da mesma maneira que nos grupos II e III. Segmentos de colo distal foram fixados em formol a 10% e processados para avaliação histológica e morfométrica. Resultados: Os resultados do experimento mostraram lesão das glândulas intestinais, vasodilatação e infiltrado leucocitário na lâmina própria e submucosa no colo dos animais pertencentes ao grupo RT que diminuiu acentudadamente após a oxigenioterapia hiperbárica. Conclusão: A oxigenitoterapia hiperbárica atenua as alterações morfológicas da mucosa e submucosa do cólon distal de ratas com enterite induzida por radiação ionizante.Purpose: To evaluate the effects of hiperbaric oxygen on the radiation-induced actinic lesions in the rat distal colon. Methods: Thirty-two Wistar female rats were divided into four groups: I - sham; II - hiperbaric oxygen therapy (HOT; III - radiotherapy (RT, e IV - radiotherapy and hiperbaric oxygen (the same manner of II and III group. Fragments of distal colon were fixed into 10% formadehyde and proceeded for the histological routine and morphology. Results: The experimental results showed the intestinal gland lesions, vasodilation and infiltrated leucocytes in propria laminae and submucosae in rat colon of GIII that accentuated colon after hiperbaric oxygen Conclusion: Hiperbaric oxygen attenuated the morphological changes in the mucosae and submucosae of the rat distal colon with radiation-induced inflammatory process.

  10. Conformal Killing vectors in Robertson-Walker spacetimes

    International Nuclear Information System (INIS)

    Maartens, R.; Maharaj, S.d.

    1986-01-01

    It is well known that Robertson-Walker spacetimes admit a conformal Killingl vector normal to the spacelike homogeneous hypersurfaces. Because these spacetimes are conformally flat, there are a further eight conformal Killing vectors, which are neither normal nor tangent to the homogeneous hypersurfaces. The authors find these further conformal Killing vectors and the Lie algebra of the full G 15 of conformal motions. Conditions on the metric scale factor are determined which reduce some of the conformal Killing vectors to homothetic Killing vectors or Killing vectors, allowing one to regain in a unified way the known special geometries. The non-normal conformal Killing vectors provide a counter-example to show that conformal motions do not, in general, map a fluid flow conformally. These non-normal vectors are also used to find the general solution of the null geodesic equation and photon Liouville equation. (author)

  11. Conformational cooling and conformation selective aggregation in dimethyl sulfite isolated in solid rare gases

    OpenAIRE

    Borba, Ana; Gómez-Zavaglia, Andrea; Fausto, Rui

    2006-01-01

    Dimethyl sulfite has three conformers of low energy, GG, GT and GG0, which have significant populations in the gas phase at room temperature. According to theoretical predictions, the GT and GG0 conformers are higher in energy than the GG conformer by 0.83 and 1.18 kJ molK1, respectively, while the barriers associated with the GG0/GT and GT/GG isomerizations are 1.90 and 9.64 kJ molK1, respectively. Experimental data obtained for the compound isolated in solid argon, krypton and xenon demonst...

  12. Conformational Diffusion and Helix Formation Kinetics

    International Nuclear Information System (INIS)

    Hummer, Gerhard; Garcia, Angel E.; Garde, Shekhar

    2000-01-01

    The time, temperature, and sequence dependences of helix formation kinetics of fully atomistic peptide models in explicit solvent are described quantitatively by a diffusive search within the coil state with barrierless transitions into the helical state. Conformational diffusion leads to nonexponential kinetics and jump-width dependences in temperature jump experiments. (c) 2000 The American Physical Society

  13. Zero curvature conditions and conformal covariance

    International Nuclear Information System (INIS)

    Akemann, G.; Grimm, R.

    1992-05-01

    Two-dimensional zero curvature conditions were investigated in detail, with special emphasis on conformal properties, and the appearance of covariant higher order differential operators constructed in terms of a projective connection was elucidated. The analysis is based on the Kostant decomposition of simple Lie algebras in terms of representations with respect to their 'principal' SL(2) subalgebra. (author) 27 refs

  14. Chromatin conformation capture strategies in molecular diagnostics

    NARCIS (Netherlands)

    de Vree, Pauline J.P.

    2015-01-01

    In this thesis I have explored the clinical potential of the 4C-technology and worked on development of a novel chromatin conformation capture based technology, called TLA. In chapter 2 I describe how the 4C-technology can be applied as a targeted strategy to identify putative fusion-genes or

  15. On the physical origin of galactic conformity

    Science.gov (United States)

    Hearin, Andrew P.; Behroozi, Peter S.; van den Bosch, Frank C.

    2016-09-01

    Correlations between the star formation rates (SFRs) of nearby galaxies (so-called galactic conformity) have been observed for projected separations up to 4 Mpc, an effect not predicted by current semi-analytic models. We investigate correlations between the mass accretion rates (dMvir/dt) of nearby haloes as a potential physical origin for this effect. We find that pairs of host haloes `know about' each others' assembly histories even when their present-day separation is greater than thirty times the virial radius of either halo. These distances are far too large for direct interaction between the haloes to explain the correlation in their dMvir/dt. Instead, halo pairs at these distances reside in the same large-scale tidal environment, which regulates dMvir/dt for both haloes. Larger haloes are less affected by external forces, which naturally gives rise to a mass dependence of the halo conformity signal. SDSS measurements of galactic conformity exhibit a qualitatively similar dependence on stellar mass, including how the signal varies with distance. Based on the expectation that halo accretion and galaxy SFR are correlated, we predict the scale-, mass- and redshift-dependence of large-scale galactic conformity, finding that the signal should drop to undetectable levels by z ≳ 1. These predictions are testable with current surveys to z ˜ 1; confirmation would establish a strong correlation between dark matter halo accretion rate and central galaxy SFR.

  16. Conformal anomaly actions for dilaton interactions

    Directory of Open Access Journals (Sweden)

    Rose Luigi Delle

    2014-01-01

    Full Text Available We discuss, in conformally invariant field theories such as QCD with massless fermions, a possible link between the perturbative signature of the conformal anomaly, in the form of anomaly poles of the 1-particle irreducible effective action, and its descrip- tion in terms of Wess-Zumino actions with a dilaton. The two descriptions are expected to capture the UV and IR behaviour of the conformal anomaly, in terms of fundamental and effective degrees of freedom respectively, with the dilaton effective state appearing in a nonlinear realization. As in the chiral case, conformal anomalies seem to be related to the appearance of these effective interactions in the 1PI action in all the gauge-invariant sectors of the Standard Model. We show that, as a consequence of the underlying anomalous symmetry, the infinite hierarchy of recurrence relations involving self-interactions of the dilaton is entirely determined only by the first four of them. This relation can be generalized to any even space-time dimension.

  17. Conformal branching rules and modular invariants

    International Nuclear Information System (INIS)

    Walton, M.A.

    1989-01-01

    Using the outer automorphisms of the affine algebra SU(n), we show how the branching rules for the conformal subalgebra SU(pq) contains SU(p) x SU(q) may be simply calculated. We demonstrate that new modular invariant combinations of SU(n) characters are obtainable from the branching rules. (orig.)

  18. Conformal constraint in canonical quantum gravity

    NARCIS (Netherlands)

    t Hooft, G.

    2010-01-01

    Perturbative canonical quantum gravity is considered, when coupled to a renormalizable model for matter fields. It is proposed that the functional integral over the dilaton field should be disentangled from the other integrations over the metric fields. This should generate a conformally invariant

  19. Synthesis and conformational features of sym ,',"-triarylguanidines

    Indian Academy of Sciences (India)

    A one pot reaction involving sym ,'-diarylthiourea and the respective arylamine in the presence of aq. KOH in nitrobenzene at ≥ 105°C afforded sym ,',"-triarylguanidine in fair to good yield and the products have been characterized. Sym ,',"-tri(4-tolyl)guanidine possesses (7) anti-anti conformation, sym ,' ...

  20. Mitochondrial Dysfunction in Protein Conformational Disorders

    Indian Academy of Sciences (India)

    EstherShlomi

    protein misfolding of α-synuclein involves conformational changes in the protein .... upon association with a membrane surface its can adopt a helical form with an 11/3 ... case of α-synuclein electrostatic interactions exist between positively ...

  1. Surveillance and Conformity in Competitive Youth Swimming

    Science.gov (United States)

    Lang, Melanie

    2010-01-01

    Underpinned by a Foucauldian analysis of sporting practices, this paper identifies the disciplinary mechanism of surveillance at work in competitive youth swimming. It highlights the ways in which swimmers and their coaches are subject to and apply this mechanism to produce embodied conformity to normative behaviour and obedient, docile bodies.…

  2. Conformally covariant composite operators in quantum chromodynamics

    International Nuclear Information System (INIS)

    Craigie, N.S.; Dobrev, V.K.; Todorov, I.T.

    1983-03-01

    Conformal covariance is shown to determine renormalization properties of composite operators in QCD and in the C 6 3 -model at the one-loop level. Its relevance to higher order (renormalization group improved) perturbative calculations in the short distance limit is also discussed. Light cone operator product expansions and spectral representations for wave functions in QCD are derived. (author)

  3. Squaraine rotaxanes with boat conformation macrocycles.

    Science.gov (United States)

    Fu, Na; Baumes, Jeffrey M; Arunkumar, Easwaran; Noll, Bruce C; Smith, Bradley D

    2009-09-04

    Mechanical encapsulation of fluorescent, deep-red bis(anilino)squaraine dyes inside Leigh-type tetralactam macrocycles produces interlocked squaraine rotaxanes. The surrounding macrocycles are flexible and undergo rapid exchange of chair and boat conformations in solution. A series of X-ray crystal structures show how the rotaxane co-conformational exchange process involves simultaneous lateral oscillation of the macrocycle about the center of the encapsulated squaraine thread. Rotaxane macrocycles with 1,4-phenylene sidewalls and 2,6-pyridine dicarboxamide bridging units are more likely to adopt boat conformations in the solid state than analogous squaraine rotaxane systems with isophthalamide-containing macrocycles. A truncated squaraine dye, with a secondary amine attached directly to the central C(4)O(2) core, is less electrophilic than the extended bis(anilino)squaraine analogue, but it is still susceptible to chemical and photochemical bleaching. Its stability is greatly enhanced when it is encapsulated as an interlocked squaraine rotaxane. An X-ray crystal structure of this truncated squaraine rotaxane shows the macrocycle in a boat conformation, and NMR studies indicate that the boat is maintained in solution. Encapsulation as a rotaxane increases the dye's brightness by a factor of 6. The encapsulation process appears to constrain the dye and reduce deformation of the chromophore from planarity. This study shows how mechanical encapsulation as a rotaxane can be used as a rational design parameter to fine-tune the chemical and photochemical properties of squaraine dyes.

  4. Dilaton vs Higgs: Nearly Conformal Physics

    Science.gov (United States)

    Kozlov, G. A.

    2016-04-01

    We consider the model in which the conformal symmetry can be broken spontaneously, and a light scalar dilaton could emerge in the low-energy spectrum. The contribution of the dark photon production relevant to two photons decays of a Higgs boson/dilaton is discussed.

  5. Conformable Pressurized Structures : Design and Analysis

    NARCIS (Netherlands)

    Geuskens, F.J.J.M.M.

    2012-01-01

    There are many applications where volume needs to be pressurised within a geometrical space for which conventional pressure vessels do not provide suitable solutions. Applications are for example found in pressure cabins for Blended Wing Body Aircraft and conformable pressure vessels for an

  6. Conformable Fractional Bessel Equation and Bessel Functions

    OpenAIRE

    Gökdoğan, Ahmet; Ünal, Emrah; Çelik, Ercan

    2015-01-01

    In this work, we study the fractional power series solutions around regular singular point x=0 of conformable fractional Bessel differential equation and fractional Bessel functions. Then, we compare fractional solutions with ordinary solutions. In addition, we present certain property of fractional Bessel functions.

  7. Conformal anomalies and the Einstein field equations

    Energy Technology Data Exchange (ETDEWEB)

    Godazgar, Hadi [Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut), Mühlenberg 1, D-14476 Potsdam (Germany); Meissner, Krzysztof A. [Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw (Poland); Nicolai, Hermann [Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut), Mühlenberg 1, D-14476 Potsdam (Germany)

    2017-04-28

    We compute corrections to the Einstein field equations which are induced by the anomalous effective actions associated to the type A conformal anomaly, both for the (non-local) Riegert action, as well as for the local action with dilaton. In all cases considered we find that these corrections can be very large.

  8. Remarks on Multi-Dimensional Conformal Mechanics

    Directory of Open Access Journals (Sweden)

    Cestmír Burdík

    2009-01-01

    Full Text Available Recently, Galajinsky, Lechtenfeld and Polovnikov proposed an elegant group-theoretical transformation of the generic conformal-invariant mechanics to the free one. Considering the classical counterpart of this transformation, we relate this transformation with the Weil model of Lobachewsky space.

  9. An introduction to conformal field theory

    International Nuclear Information System (INIS)

    Zuber, J.B.

    1995-01-01

    The aim of these lectures is to present an introduction at a fairly elementary level to recent developments in two dimensional field theory, namely in conformal field theory. We shall see the importance of new structures related to infinite dimensional algebras: current algebras and Virasoro algebra. These topics will find physically relevant applications in the lectures by Shankar and Ian Affeck. (author)

  10. Conformation of hindered piperidines: Spectroscopic evidence for ...

    Indian Academy of Sciences (India)

    Administrator

    presence of an equilibrium mixture of boat forms B1 and B2 for Z isomers of 5–8. For the E isomers of. 5–8, boat form B1 ... C NMR; conformational analysis; boat forms. 1. Introduction. Many piperidine derivatives are found to possess pharmacological activity and form an essential part of the molecular structure of important ...

  11. Local supertwistors and N=2 conformal supergravity

    International Nuclear Information System (INIS)

    Merkulov, S.A.

    1989-01-01

    N = 2 sypersymmetric extension of the local twistor theory is formulated. A supertwistor superconnection determined by the superconformal structure of the base superspace is introduced on the bundle of N = 2 local supertwistors. It is proved that the Yang - Mills equations for this superconnection coincide exactly with the Bach equations describing the dynamics of N 2 conformal supergravity

  12. Dynamical interpretation of nonrelativistic conformal groups

    International Nuclear Information System (INIS)

    Andrzejewski, K.; Gonera, J.

    2013-01-01

    It is shown that N-Galilean conformal algebra with N odd and nontrivial central charge is the maximal symmetry algebra for higher derivative free theory both on classical and quantum levels. By maximal symmetry algebra the Lie algebra of the maximal group of space–time symmetry transformations is understood which preserves higher order free dynamics

  13. Does Your Annual Financial Report Conform?

    Science.gov (United States)

    Foster, Charles W.

    1977-01-01

    Requirements for consideration of the Certificate of Conformance award sponsored by the Association of School Business Officials to encourage school districts to adopt and use generally accepted accounting and reporting principles for all funds used in the financial management of the school systems. (Author/MLF)

  14. Conformational change of spin labelled myoglobin

    International Nuclear Information System (INIS)

    Wajnberg, E.; Ribeiro, P.C.; Nascimento, O.R.; Bemski, G.

    1978-01-01

    A conformational change of spin labelled myoglobin have been followed by measuring the spin label's (isothiocyanate) correlation time for temperatures between 18 0 C and 44 0 C. The correlation time was calculated from Electrom Paramagnetic Ressonance Spectra using the components of the espectroscopic and hiperfine tensors obtained by fitting the powder spectra using Lefebvre and Maruani's program- [pt

  15. Conformational Diffusion and Helix Formation Kinetics

    Energy Technology Data Exchange (ETDEWEB)

    Hummer, Gerhard [Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520 (United States); Garcia, Angel E. [Theoretical Biology and Biophysics Group T-10, MS K710, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Garde, Shekhar [Department of Chemical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, New York 12180 (United States)

    2000-09-18

    The time, temperature, and sequence dependences of helix formation kinetics of fully atomistic peptide models in explicit solvent are described quantitatively by a diffusive search within the coil state with barrierless transitions into the helical state. Conformational diffusion leads to nonexponential kinetics and jump-width dependences in temperature jump experiments. (c) 2000 The American Physical Society.

  16. On holography for (pseudo-)conformal cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Libanov, M. [Institute for Nuclear Research of the Russian Academy of Sciences, 60th October Anniversary Prospect, 7a, 117312, Moscow (Russian Federation); Moscow Institute of Physics and Technology, Institutskii per., 9, 141700, Dolgoprudny, Moscow Region (Russian Federation); Rubakov, V. [Institute for Nuclear Research of the Russian Academy of Sciences, 60th October Anniversary Prospect, 7a, 117312, Moscow (Russian Federation); Department of Particle Physics and Cosmology, Physics Faculty, Moscow State University, Vorobjevy Gory, 119991, Moscow (Russian Federation); Sibiryakov, S., E-mail: sibir@ms2.inr.ac.ru [Institute for Nuclear Research of the Russian Academy of Sciences, 60th October Anniversary Prospect, 7a, 117312, Moscow (Russian Federation); Theory Group, Physics Department, CERN, CH-1211 Geneva 23 (Switzerland); FSB/ITP/LPPC, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne (Switzerland)

    2015-02-04

    We propose a holographic dual for (pseudo-)conformal cosmological scenario, with a scalar field that forms a moving domain wall in adS{sub 5}. The domain wall separates two vacua with unequal energy densities. Unlike in the existing construction, the 5d solution is regular in the relevant space–time domain.

  17. Black Hole Monodromy and Conformal Field Theory

    NARCIS (Netherlands)

    Castro, A.; Lapan, J.M.; Maloney, A.; Rodriguez, M.J.

    2013-01-01

    The analytic structure of solutions to the Klein-Gordon equation in a black hole background, as represented by monodromy data, is intimately related to black hole thermodynamics. It encodes the "hidden conformal symmetry" of a nonextremal black hole, and it explains why features of the inner event

  18. Conformity to the Surviving Sepsis Campaign International ...

    African Journals Online (AJOL)

    Background: There are emerging therapies for managing septic critically-ill patients. There is little data from the developing world on their usage. Objectives: To determine the conformity rate for resuscitation and management bundles for septic patients amongst physicians in a general intensive care unit. Design: Cross ...

  19. Conformational regulation of urokinase receptor function

    DEFF Research Database (Denmark)

    Gårdsvoll, Henrik; Jacobsen, Benedikte; Kriegbaum, Mette C

    2011-01-01

    PA per se into the hydrophobic ligand binding cavity of uPAR that modulates the function of this receptor. Based on these data, we now propose a model in which the inherent interdomain mobility in uPAR plays a major role in modulating its function. Particularly one uPAR conformation, which is stabilized...

  20. Holographic applications of logarithmic conformal field theories

    NARCIS (Netherlands)

    Grumiller, D.; Riedler, W.; Rosseel, J.; Zojer, T.

    2013-01-01

    We review the relations between Jordan cells in various branches of physics, ranging from quantum mechanics to massive gravity theories. Our main focus is on holographic correspondences between critically tuned gravity theories in anti-de Sitter space and logarithmic conformal field theories in

  1. On holography for (pseudo-)conformal cosmology

    CERN Document Server

    Libanov, M.; Sibiryakov, S.

    2015-01-01

    We propose a holographic dual for (pseudo-)conformal cosmological scenario, with a scalar field that forms a moving domain wall in adS_5. The domain wall separates two vacua with unequal energy densities. Unlike in the existing construction, the 5d solution is regular in the relevant space-time domain.

  2. Avaliação hormonal indireta e estudo da preservação folicular em tecido ovariano autólogo transplantado para região inguinal em ratos

    Directory of Open Access Journals (Sweden)

    Ceschin Álvaro Pigatto

    2004-01-01

    Full Text Available OBJETIVO: O transplante autólogo de tecido ovariano tem sido objeto de estudo de diversos pesquisadores pela perspectiva de manter a funcionalidade deste órgão, mesmo não localizado em seu sítio habitual, sendo daí removido, a fim de minimizar os efeitos causados, por exemplo, pela radioterapia. Este trabalho visa a analisar a efetividade da técnica de autotransplante subcutâneo de tecido ovariano bisseccionado em região inguinal de ratas albinas, próximo aos vasos femorais, através do estudo indireto da produção hormonal, feita pela avaliação da citologia de esfregaços vaginais e do estudo direto da viabilidade tecidual, realizado por meio da análise histológica. MÉTODOS: Analisaram-se 30 ratas, que sofreram ooforectomia bilateral, sendo 15 delas destinadas ao controle e 15 submetidas ao transplante ovariano. Decorridos 28 dias, recuperaram-se e avaliaram-se os enxertos. As análises da citologia dos esfregaços vaginais efetuaram-se no momento 0, ou seja, pré-transplante, e no momento 1, pós-transplante, para os animais de ambos os grupos e a avaliação histológica realizou-se no momento 0 para os dois grupos e no momento 1 para os animais transplantados. RESULTADOS: Os resultados do experimento demonstraram a viabilidade e funcionalidade dos enxertos em 100% das lâminas analisadas, isso verificado através da obtenção de esfregaços em fase de estro para todas as ratas do grupo experimento e da presença de folículos em vários estágios de desenvolvimento, observados nos enxertos recuperados, indicando diretamente a viabilidade do tecido ovariano. CONCLUSÃO: o transplante de tecido ovariano é uma alternativa viável, nas condições do experimento, para a preservação hormonal e folicular, em ratas.

  3. Advanced Small Animal Conformal Radiation Therapy Device.

    Science.gov (United States)

    Sharma, Sunil; Narayanasamy, Ganesh; Przybyla, Beata; Webber, Jessica; Boerma, Marjan; Clarkson, Richard; Moros, Eduardo G; Corry, Peter M; Griffin, Robert J

    2017-02-01

    We have developed a small animal conformal radiation therapy device that provides a degree of geometrical/anatomical targeting comparable to what is achievable in a commercial animal irradiator. small animal conformal radiation therapy device is capable of producing precise and accurate conformal delivery of radiation to target as well as for imaging small animals. The small animal conformal radiation therapy device uses an X-ray tube, a robotic animal position system, and a digital imager. The system is in a steel enclosure with adequate lead shielding following National Council on Radiation Protection and Measurements 49 guidelines and verified with Geiger-Mueller survey meter. The X-ray source is calibrated following AAPM TG-61 specifications and mounted at 101.6 cm from the floor, which is a primary barrier. The X-ray tube is mounted on a custom-made "gantry" and has a special collimating assembly system that allows field size between 0.5 mm and 20 cm at isocenter. Three-dimensional imaging can be performed to aid target localization using the same X-ray source at custom settings and an in-house reconstruction software. The small animal conformal radiation therapy device thus provides an excellent integrated system to promote translational research in radiation oncology in an academic laboratory. The purpose of this article is to review shielding and dosimetric measurement and highlight a few successful studies that have been performed to date with our system. In addition, an example of new data from an in vivo rat model of breast cancer is presented in which spatially fractionated radiation alone and in combination with thermal ablation was applied and the therapeutic benefit examined.

  4. Enhanced conformational sampling using enveloping distribution sampling.

    Science.gov (United States)

    Lin, Zhixiong; van Gunsteren, Wilfred F

    2013-10-14

    To lessen the problem of insufficient conformational sampling in biomolecular simulations is still a major challenge in computational biochemistry. In this article, an application of the method of enveloping distribution sampling (EDS) is proposed that addresses this challenge and its sampling efficiency is demonstrated in simulations of a hexa-β-peptide whose conformational equilibrium encompasses two different helical folds, i.e., a right-handed 2.7(10∕12)-helix and a left-handed 3(14)-helix, separated by a high energy barrier. Standard MD simulations of this peptide using the GROMOS 53A6 force field did not reach convergence of the free enthalpy difference between the two helices even after 500 ns of simulation time. The use of soft-core non-bonded interactions in the centre of the peptide did enhance the number of transitions between the helices, but at the same time led to neglect of relevant helical configurations. In the simulations of a two-state EDS reference Hamiltonian that envelops both the physical peptide and the soft-core peptide, sampling of the conformational space of the physical peptide ensures that physically relevant conformations can be visited, and sampling of the conformational space of the soft-core peptide helps to enhance the transitions between the two helices. The EDS simulations sampled many more transitions between the two helices and showed much faster convergence of the relative free enthalpy of the two helices compared with the standard MD simulations with only a slightly larger computational effort to determine optimized EDS parameters. Combined with various methods to smoothen the potential energy surface, the proposed EDS application will be a powerful technique to enhance the sampling efficiency in biomolecular simulations.

  5. Development in technology and medical physics in radiotherapy: special considerations hadron therapy; Evolucion de la tecnica y de la fisica medica en radioterapia: consideraciones especiales sobre hadronterapia

    Energy Technology Data Exchange (ETDEWEB)

    Mazai, A.; Losa, S.; Farias, R.; Cell, J. c.; Perez, J.; Olivera, G.; Galmarini, D.; Prezado, Y.; Faus-Golfe, A.; Sanchez Parcerisa, D.; Carbe, A.; Venencia, D.; Andreo, P.; Fourquet, A.

    2016-08-01

    This work presents some recent advances in technology and medical physics in the field of radiation oncology. If stands out the progress in anatomical and functional imaging, the availability of beams of photons and charged particles with multiples incidences on the patient, the conformal and monitoring device, as well as the software to calculate and to control the treatments. There is a description of concepts such as intensity modulation, image guided and adaptive radiation therapy, transit dosimetry, hadron therapy and the importance of research in radiation biology, including practical examples. It concludes with the need to evaluate the clinical relevance and the economical aspects of all this advances, as well as how to apply them to get personalized treatments in combination with molecular biology and to spread these benefits to large populations. (Author)

  6. Conformational analysis of oligosaccharides and polysaccharides using molecular dynamics simulations.

    Science.gov (United States)

    Frank, Martin

    2015-01-01

    Complex carbohydrates usually have a large number of rotatable bonds and consequently a large number of theoretically possible conformations can be generated (combinatorial explosion). The application of systematic search methods for conformational analysis of carbohydrates is therefore limited to disaccharides and trisaccharides in a routine analysis. An alternative approach is to use Monte-Carlo methods or (high-temperature) molecular dynamics (MD) simulations to explore the conformational space of complex carbohydrates. This chapter describes how to use MD simulation data to perform a conformational analysis (conformational maps, hydrogen bonds) of oligosaccharides and how to build realistic 3D structures of large polysaccharides using Conformational Analysis Tools (CAT).

  7. Lie algebra of conformal Killing–Yano forms

    International Nuclear Information System (INIS)

    Ertem, Ümit

    2016-01-01

    We provide a generalization of the Lie algebra of conformal Killing vector fields to conformal Killing–Yano forms. A new Lie bracket for conformal Killing–Yano forms that corresponds to slightly modified Schouten–Nijenhuis bracket of differential forms is proposed. We show that conformal Killing–Yano forms satisfy a graded Lie algebra in constant curvature manifolds. It is also proven that normal conformal Killing–Yano forms in Einstein manifolds also satisfy a graded Lie algebra. The constructed graded Lie algebras reduce to the graded Lie algebra of Killing–Yano forms and the Lie algebras of conformal Killing and Killing vector fields in special cases. (paper)

  8. Conformal symmetry in two dimensions: An explicit recurrence formula for the conformal partial wave amplitude

    International Nuclear Information System (INIS)

    Zamolodchikov, A.B.

    1984-01-01

    An explicit recurrence relation for the conformal block functions is presented. This relation permits one to evaluate the X-expansion of these functions order-by-order and appropriate for numerical calculations. (orig.)

  9. Reactions driving conformational movements (molecular motors) in gels: conformational and structural chemical kinetics.

    Science.gov (United States)

    Otero, Toribio F

    2017-01-18

    In this perspective the empirical kinetics of conducting polymers exchanging anions and solvent during electrochemical reactions to get dense reactive gels is reviewed. The reaction drives conformational movements of the chains (molecular motors), exchange of ions and solvent with the electrolyte and structural (relaxation, swelling, shrinking and compaction) gel changes. Reaction-driven structural changes are identified and quantified from electrochemical responses. The empirical reaction activation energy (E a ), the reaction coefficient (k) and the reaction orders (α and β) change as a function of the conformational energy variation during the reaction. This conformational energy becomes an empirical magnitude. E a , k, α and β include and provide quantitative conformational and structural information. The chemical kinetics becomes structural chemical kinetics (SCK) for reactions driving conformational movements of the reactants. The electrochemically stimulated conformational relaxation model describes empirical results and some results from the literature for biochemical reactions. In parallel the development of an emerging technological world of soft, wet, multifunctional and biomimetic tools and anthropomorphic robots driven by reactions of the constitutive material, as in biological organs, can be now envisaged being theoretically supported by the kinetic model.

  10. Genetic analyses for conformation traits in South African Jersey and ...

    African Journals Online (AJOL)

    JACO

    Genetic trends for conformation traits of the South African Holstein show that ... conformation traits can be used to improve stayability, fertility and disease resistance (Rogers et al., 1999; .... Genetic correlations among protein yield, productive.

  11. Conformal invariant quantum field theory and composite field operators

    International Nuclear Information System (INIS)

    Kurak, V.

    1976-01-01

    The present status of conformal invariance in quantum field theory is reviewed from a non group theoretical point of view. Composite field operators dimensions are computed in some simple models and related to conformal symmetry

  12. Evaluating uncertainties in the cross-calibration of parallel ion chambers used in electron beam radiotherapy; Avaliacao das incertezas no processo de calibracao cruzada de camaras de placas paralelas utilizadas em feixes de eletrons para radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Ernani; Travassos, Paulo; Ferreira, Max da Silva; Carvalho, Samira Marques de; Silva, Michele Maria da; Peixoto, Jose Guilherme Pereira, E-mail: ernanianderson@hotmail.com [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Salmon Junior, Helio Augusto [Grupo COI - Clinicas Oncologicas, Rio de Janeiro, RJ (Brazil)

    2015-07-01

    This study aims to estimative the combined standard uncertainty for a detector parallel plate used for dosimetry of electron beams in linear accelerators for radiotherapy, which has been calibrated by the cross-calibration method. Keeping the combined standard uncertainty next of the uncertainty informed in the calibration certificate of the reference chamber, become possible establish the calibration factor of the detector. The combined standard uncertainty obtained in this study was 2.5 %. (author)

  13. Study of the spheronization process of glass particles by the gravitational falling process for internal selective radiotherapy; Estudo do processo de esferolizacao por queda gravitacional de particulas vitreas visando a aplicacao em radioterapia interna seletiva

    Energy Technology Data Exchange (ETDEWEB)

    Barros Filho, E.C.; Martinelli, J.R., E-mail: eraldo.filho@usp.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), SP (Brazil); Sene, F.F. [Centro Tecnologico da Marinha em Sao Paulo (CTMS), Sao Paulo, SP (Brazil)

    2011-07-01

    The internal selective radiotherapy is an alternative to treat hepatocellular carcinoma. Glass microspheres containing β{sup -} emitter radionuclide are introduced in the liver, and they are housed preferentially in the region where the cancer cells are located. The microspheres are trapped in the arterioles which feed the tumors, and the β{sup -} particles annihilate the cancer cells. The glass particles must be spherical to avoid unnecessary bleeding, and the particle size must be restricted to a range which optimizes the blocking effect and avoid the migration to other parts of the human body. The particle size distribution of microspheres is not easily predicted since the variation of the aspect ratio and the presence of agglomerates can influence the resulting particle size distribution. In the present work, the spheronization process to obtain microspheres from irregular shape glass particles with suitable diameter and shape for radiotherapy treatment is studied. (author)

  14. Assessment of influence of OSL dosimeters in the skin dose in radiotherapy: study for Monte Carlo simulation; Avaliacao da influencia de dosimetros OSL na dose na pele em radioterapia: estudo por simulacao Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Schuch, Franciely F.; Nicolucci, Patricia, E-mail: franschuch@yahoo.com.br [Universidade de Sao Paulo (USP), Ribeiraoo Preto, SP (Brazil)

    2017-11-01

    The interest in optically stimulated luminescence (OSL) dosimetry materials is growing due to its potential use in quality control in Radiotherapy. The use of these dosimeters for in vivo dosimetry, however, may influence the dose to the skin and deeper tissues in the patient. The goal of this study is to evaluate the influence of the OSL Al{sub 2}O{sub 3} material in dose deposited in the skin and deep in Radiotherapy. Monte Carlo simulation is used to evaluate this purpose when OSL dosimeters of Al{sub 2}O{sub 3} are positioned on the skin surface of the patient. Percentage depth dose curves for clinical beams of 6 and 10 MV were simulated with and without the presence of the dosimeter on the surface of a water phantom. The results showed a decrease of doses in regions close to the surface of the skin. In the build-up region, the maximum decreases of dose produced by the presence of the dosimeters were 52,5% and 47,5% for the 6 and 10 MV beams, respectively. After the build-up region, there are not significant changes in the doses for any of the used beams. The differences of doses found are due to the influence of the dosimetric material on the relative fluence of electrons near the end surface of the dosimeter. Thus, the results showed that the presence of the dosimetric material on the surface interferes on the skin dose. However, these dosimeters do not cause dose variations in depths of clinical interest, allowing its application in routine in vivo dosimetry in Radiotherapy. (author)

  15. Lessons learned from radiological accidents at medical exposures in radiotherapy; Lições aprendidas com acidentes radiológicos nas exposições médicas em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Fagundes, J.S.; Ferreira, A.F. [Faculdade Casa Branca, SP (Brazil); Lima, C.M.A. [MAXIM Cursos, Rio de Janeiro, RJ (Brazil); Silva, F.C.A. da, E-mail: franciscodasilva13uk@gmail.com [Instituto de Radioproteção e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2017-07-01

    An exposure is considered accidental in radiotherapy when there is a substantial deviation in the prescription of treatment. In this work, an analysis of published radiological accidents, both in Brazil and internationally, was performed during medical exposures in radiotherapy treatments, removing the main lessons learned. Of the research carried out, we highlight Brazil with four radiological accidents and one death in the period between 2011 and 2014; the United States of America with 169 accidents with two deaths from 2000 to 2010 and France from 2001 to 2014 had 569 deaths without patients. Lessons learned have been described, for example, that maintenance personnel training should specify limitations or restrictions on the handling or adjustment of critical parts on the accelerator. It is recommended to apply the 10 main lessons learned due to radiological accidents during medical exposures in radiotherapy treatments to avoid future events.

  16. Multivariate analysis of the prognostic factors of squamous cell cervical cancer treated by radical hysterectomy or combined radiation therapy; Carcinoma espinocelular do colo uterino submetido a cirurgia radical isolada ou em combinacao com radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Coelho, Francisco Ricardo Gualda; Kowalski, Luiz Paulo; Abrao, Fauzer Simao [Fundacao Antonio Prudente, Sao Paulo, SP (Brazil). Hospital A.C. Camargo; Franco, Eduardo Luiz [McGill Univ., Montreal, PQ (Canada). Dept. of Oncology; Zeferino, Luiz Carlos [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Medicina; Brentani, Maria Mitzi [Sao Paulo Univ., SP (Brazil). Faculdade de Medicina

    1996-04-01

    Six hundred and nine cases of invasive squamous cell carcinoma of the cervix uteri in a retrospective analysis (1953-1982) at the A.C. Camargo Hospital, Antonio Prudente Foundation, Sao Paulo, Brazil. The patients were submitted to radical surgery and radiation therapy, individually or in combination. A multivariate analysis of the different variables were performed according to the Cox`s regression method. The variables of prognosis value, in decreasing order of importance, were: the decade of patient`s admission, the modality of therapy employed, the presence of residual tumor in the surgical specimens and the clinical stage of the disease. Other variables like ethnic group, age of first menstrual flux, menopause, number of pregnancy, kind of delivery, number and kind of abortion, were found to be of no prognostic importance. The decade of admission was of independent prognostic significance. The presence of residual tumor in the surgical specimens was more important than lymph nodes spreading, but the overall survival was affected by the increase in the number of positive lymph nodes. Patient`s age was a weak prognostic factor accounting for a reduction in the survival time among cases with age upper to 45 years old. Radiation therapy sterilizes a considerable number of lymph nodes but not all of them in every patient. There are a specific group of patients where the radical surgery is necessary in order to carry a complete debulking of the disease. (author) 82 refs., 10 figs.

  17. Analysis of dose in heterogeneity adjuvant radiotherapy after surgical treatment of cases of breast cancer; Analise da heterogeneidade de dose em radioterapia adjuvante apos tratamento cirurgico de casos de cancer de mama

    Energy Technology Data Exchange (ETDEWEB)

    Grechi, Bruna E.; Schwarz, Ana Paula, E-mail: anapaulaschwarz@yahoo.com.br [Centro Universitario Franciscano (UNIFRA), Santa Maria, RS (Brazil); Teston, Adriano; Rodrigues, Joanilso S. [Clinica de Radioterapia Santa Maria, Santa Maria, RS (Brazil)

    2013-12-15

    Assuming the systems planning radiotherapy recognize all body structures of the same density (d=1 g/cm³), variations in electron density within the irradiated area, as is the case of patients who undergo reconstruction mammary processes and use tissue expanders, may influence the dose distribution in the treatment and may produce heterogeneities which are not measured by changing its actual distribution into healthy tissues or in the target volume to be irradiated. Through the calculation of the algorithms' dose distribution of the XiO® planning system (Fast Fourier Transform, Convolution, Superposition, Fast Superposition e Clarkson), when using correction of heterogeneity between tissues of different densities, there was obtained a percentage ratio of dose increase in the structures of interest, and of the amount of absorbed dose by healthy organs adjacent to the target volume. (author)

  18. Development and implementation of a software for assessment of calculations in radiotherapy monitor units; Elaboracao e implementacao de um programa para verificacao dos calculos das unidades monitoras em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Marcio Rogerio; Silva, Marco Antonio da; Rodrigues, Laura Natal [Sao Paulo Univ., SP (Brazil). Hospital das Clinicas. Servico de Radioterapia]. E-mail: mrmuller@usp.br

    2005-12-01

    Objective: To develop and implement a software based on the manual calculation algorithm for verification of the calculations in radiotherapy monitor units and to establish acceptance levels as a mechanism of quality assurance. Materials and methods: Data were obtained from Clinac 600C and 2100C Varian linear accelerators and the computerized treatment planning system used was CadPlan{sup TM}. Results: For the 6 MV beams the acceptance levels for deviations among the calculations of monitor units, divided by treatment area, were the following: breast (0.0%{+-}1.7%), head and neck (1.5%{+-}0.5%), hypophysis (-1.7%{+-}0.5%), pelvis (2.1%{+-}2.1%) and thorax (0.2%{+-}1.3%). For the 15 MV beams the suggested level for pelvis in all the treatment techniques was (3.2%{+-}1.3%). Conclusion: The present data are sufficient to justify the use of the software in the clinical practice as a tool for the quality assurance program. (author)

  19. Computational voxel phantom, associated to anthropometric and anthropomorphic real phantom for dosimetry in human male pelvis radiotherapy; Fantoma computacional de voxel, associado a fantoma real antropomorfico antropometrico, para dosimetria em radioterapia de pelve masculina

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Cleuza Helena Teixeira; Campos, Tarcisio Passos Ribeiro de [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Programa de Pos-graduacao em Ciencias e Tecnicas Nucleares]. E-mail: campos@nuclear.ufmg.br

    2005-07-01

    This paper addresses a computational model of voxels through MCNP5 Code and the experimental development of an anthropometric and anthropomorphic phantom for dosimetry in human male pelvis brachytherapy focusing prostatic tumors. For elaboration of the computational model of the human male pelvis, anatomical section images from the Visible Man Project were applied. Such selected and digital images were associated to a numeric representation, one for each section. Such computational representation of the anatomical sections was transformed into a bi-dimensional mesh of equivalent tissue. The group of bidimensional meshes was concatenated forming the three-dimensional model of voxels to be used by the MCNP5 code. In association to the anatomical information, data from the density and chemical composition of the basic elements, representatives of the organs and involved tissues, were setup in a material database for the MCNP-5. The model will be applied for dosimetric evaluations in situations of irradiation of the human masculine pelvis. Such 3D model of voxel is associated to the code of transport of particles MCNP5, allowing future simulations. It was also developed the construction of human masculine pelvis phantom, based on anthropometric and anthropomorphic dates and in the use of representative equivalent tissues of the skin, fatty, muscular and glandular tissue, as well as the bony structure.This part of work was developed in stages, being built the bony cast first, later the muscular structures and internal organs. They were then jointly mounted and inserted in the skin cast. The representative component of the fatty tissue was incorporate and accomplished the final retouchings in the skin. The final result represents the development of two important essential tools for elaboration of computational and experimental dosimetry. Thus, it is possible its use in calibrations of pre-existent protocols in radiotherapy, as well as for tests of new protocols, besides comparative studies among different clinical protocols. (author)

  20. Neutron Skyshine in shielding projects of radiotherapy: comparison between theoretical approach and simulation by Monte Carlo method; 'Skyshine' de neutrons em projetos de blindagens de radioterapia: comparacao entre abordagem teorica e simulacao por metodo de Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Falcao, R.C.; Facure, A. [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Santini, E.S. [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil); Silva, A.X. [Coordenacao dos Programas de Pos-Graduacao de Engenharia (PEN/COPPE/UFRJ), RJ (Brazil). Programa de Engenharia Nuclear

    2005-07-01

    In this work, the MCNP code is used to simulate the transport of neutrons in a room of radiotherapy, whose shieldings are designed according to the method of skyshine (scattering in the atmosphere). The simulations are compared with the results obtained from empirically established expressions, which are normally used for designing the ceilings of the rooms facilities, ensuring that dose rates (neutrons + photons) around them do not exceed the maximum limits allowed by the standards of the CNEN. Good agreement is observed between the doses calculated according to these expressions and those obtained through simulation by Monte Carlo in the case of rooms without ceiling, and an overestimate of the calculations by a factor 2 or 3 in relation to the simulations, in the case of rooms with ceiling.

  1. Development of a computational model for the calculation of neutron dose equivalent in laminated primary barriers of radiotherapy rooms; Desenvolvimento de um modelo computacional para calculo do equivalente de dose de neutrons em barreiras primarias laminadas de salas de radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Rezende, Gabriel Fonseca da Silva

    2015-06-01

    Many radiotherapy centers acquire 15 and 18 MV linear accelerators to perform more effective treatments for deep tumors. However, the acquisition of these equipment must be accompanied by an additional care in shielding planning of the rooms that will house them. In cases where space is restricted, it is common to find primary barriers made of concrete and metal. The drawback of this type of barrier is the photoneutron emission when high energy photons (e.g. 15 and 18 MV spectra) interact with the metallic material of the barrier. The emission of these particles constitutes a problem of radiation protection inside and outside of radiotherapy rooms, which should be properly assessed. A recent work has shown that the current model underestimate the dose of neutrons outside the treatment rooms. In this work, a computational model for the aforementioned problem was created from Monte Carlo Simulations and Artificial Intelligence. The developed model was composed by three neural networks, each being formed of a pair of material and spectrum: Pb18, Pb15 and Fe18. In a direct comparison with the McGinley method, the Pb18 network exhibited the best responses for approximately 78% of the cases tested; the Pb15 network showed better results for 100% of the tested cases, while the Fe18 network produced better answers to 94% of the tested cases. Thus, the computational model composed by the three networks has shown more consistent results than McGinley method. (author)

  2. Calculation of conversion factor of Kerma in the air for ambient dose equivalent in radiotherapy; Calculo dos fatores de conversao de Kerma no ar para equivalente de dose ambiental em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Lima, Marco Antonio Frota

    2000-03-01

    This work aims to estimate the average conversion factor of Kerma in air to H {sup *} (10) using photon beams coming from clinic linear accelerators, transmitted through concrete walls of a radiotherapic treatment room. The transmitted photon spectra by both 1 meter and 2 meters concrete walls, in an area of 40 x 40 cm{sup 2}, were calculated when the primary beam impart in an angle of 0 deg. The (secondary) photon beams transmitted respectively by 0,5 meter, 1,0 meter, 1,0 meter and 2,0 meter concrete walls, after they scattered by an angle of 90 deg in a cylindric phantom inside the room, were also determined. Generally, 50 millions of histories were computed for each simulation made for the primary beam. For the 90 deg spread, the number of histories was 100 millions. The computational code used on this work was the MCNP4B. The most common clinic accelerators used on radiotheraphic treatments were used on this work CLINAC-4, CLINAC-6, CLINAC-18 and CLINAC-2500. From the spectra analysis obtained in this work, it was possible to dispose the conversion factor for realistic beams found in radiotherapeutic establishment. (author)

  3. Study of air cavities influence in head and neck radiotherapy with 10 MV photon beam; Estudo da influencia de cavidades de ar em radioterapia de cabeca e pescoco com feixe de fotons de 10 MV

    Energy Technology Data Exchange (ETDEWEB)

    Souza, C.N. de

    1989-03-01

    This is a study about dose distribution in the larynx region under irradiation with a 10 MV photon beam. This localization presents air cavities, that can compromise the dose at air-tissue interfaces by electronic equilibrium loss and backscattering lack. For this study, a parallel ionization chamber was used in the air cavities simulated with a perspex phantom. The influence of the air cavities in the proximal, distal and lateral interfaces was analysed. The results showed a expressive loss of dose at the air-tissue interface. For typical irradiation field and anatomic cavity, under dose values of 4% in the proximal interface, 11% in the distal interface and 7% in the lateral interface were found. Irradiation field larger than 6 X 6 cm{sup 2} were optimal in reducing the total effect of under dosing at the interface. (author). 39 refs, 23 figs, 12 tabs.

  4. Radiation therapy using the wildlife medicine: a reasoned obtained study in cases of literature; Utilizacao da radioterapia na medicina de animais selvagens: um estudo fundamentado em casos obtidos da literatura

    Energy Technology Data Exchange (ETDEWEB)

    Vettorato, Michel de Campos; Fernandes, Marco Antonio Rodrigues; Vulcano, Luis Carlos [Universidade Estadual Paulista Julio de Mesquita Filho (FMVZ/UNESP), Botucatu, SP (Brazil). Faculdade de Medicina Veterinaria e Zootecnia; Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Botucatu, SP (Brazil). Dept. de Dermatologia e Radioterapia

    2016-03-15

    The cancer is the kind of tumor that affects both humans and animals and is responsible for more deaths worldwide. In wildlife, cancer is a problem found most often in zoo animals. Thus veterinary oncologists have researched and developed therapeutic approaches to many types of cancer over the years in both curative and palliative therapies including therein the application of radiation. The basic principle of radiotherapy is the effect of ionizing radiation on the tumor cells, causing them to death. However, its application in veterinary medicine for wildlife is not much reported in the literature, especially in Brazil. This study aims to describe and compare some of radiotherapy applications in different species of wildlife looking to improve her knowledge in veterinary medicine through a brief literature review. After the descriptions and comparisons, it is concluded that despite the number of cases taken for this study, all the cases mentioned had satisfactory results using radiation therapy and all the presented cases provided relevant information that can guide future researchers in this area, thus improving knowledge of this therapy and improve the quality of life of animals. (author)

  5. Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors; Avaliacao de algumas sequelas bucais pos-radioterapia em pacientes tratados de neoplasias de cabeca e pescoco

    Energy Technology Data Exchange (ETDEWEB)

    Rubira, Cassia Maria Fischer; Devides, Nadia Juliana; Ubeda, Liliane Torsani; Lauris, Jose Roberto; Rubira-Bullen, Izabel Regina Fischer; Damante, Jose Humberto [University of Sao Paulo, Bauru, SP (Brazil). School of Dentistry. Stomatology Dept.; Bortolucci Junior, Antonio Geraldo [Amaral Carvalho Hospital, Jau, SP (Brazil)]. E-mail: damante@fob.usp.br

    2007-07-01

    The aim of this study was to evaluate the oral sequelae of radiotherapy in patients treated between 1999 and 2003 for head and neck tumors. One-hundred patients (24 women, 76 men) ranging in age from 30 to 83 years (mean 59.2 years) were examined. Time since radiotherapy ranged from 1 to 72 months (mean 28 months). The total mean radiation dose received by the patients was 5,955 cGy. The evaluation protocol included anamnesis, intraoral and extraoral examination, measurement of stimulated salivary flow and salivary pH. Symptoms reported by the patients included dry mouth (68%), dysphagia (38%), and dysgeusia (30%). In 64% of the patients, the mean stimulated salivary flow rate was less than 0.7 ml/min. The mean salivary pH was 6.97 ({+-} 0.714). Stimulated salivary flow increased with increasing postradiotherapy time (p < 0.05). The prevalence of mucositis was associated with higher radiation doses (p < 0.05), and the prevalence of atrophic candidiasis was related to a longer post-treatment period (p < 0.05). Two cases of recurrence of the primary tumor were detected during the study. The main effect of radiotherapy in the head and neck region was a reduction of the salivary flow rate, even though our study demonstrated that there was a modest late improvement of the salivary flow. (author)

  6. Verification of the patient positioning for evaluation of PTV margins in radiotherapy of prostate cancer; Verificacao do posicionamento do paciente para a avaliacao das margens de PTV em radioterapia do cancer de prostata

    Energy Technology Data Exchange (ETDEWEB)

    Frohlich, B.F.; Peron, T.M.; Scheid, A.M.; Cardoso, F.; Alves, F.; Alves, M.S.; Dias, T.M. [Hospital de Clinicas de Porto Alegre, RS (Brazil)

    2016-07-01

    The work aimed to verify the relative displacements between the patient and the isocenters of the device based on the reproducibility of positioning, and estimates a PTV margins of radiotherapy treatments for prostate cancer. The results of displacements were obtained from a sample of 30 patient and showed values in vertical, longitudinal and lateral directions -0.03 ± 0.48 cm, 0.12 ± 0.47 cm and 0.02 ± 0.53 cm, respectively. PTV margins were calculated resulting in 0.97 cm for vertical direction, 0.85 cm for longitudinal, and 0.98 cm for lateral. (author)

  7. Elaboration and implementation of standard operational procedure for quality assurance of cone beam CT image in radiotherapy; Elaboracao e implementacao de procedimentos operacionais padrao para controle de qualidade da imagem CBCT em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Bonatto, Larisse N.; Estacio, Daniela R.; Lopes, Juliane S.; Sansson, Angela; Duarte, Lucas O.; Sbaraini, Patricia, E-mail: larisse.neumann@pucrs.br [Hospital Sao Lucas (PUC-RS), Porto Alegre, RS (Brazil). Servico de Radioterapia; Silva, Ana M. Marques da; Streck, Elaine E. [Pontificia Universidade Catolica do Rio Grande do Sukl (PUC-RS), Porto Alegre, RS (Brazil). Faculdade de Fisica

    2016-07-01

    The aim of this paper is to present the implementation of image quality control of the computed tomography cone beam (CBCT), generated by the On-Board Imager device, and integrated into the linear accelerator Trilogy. To this end, standard operating procedures (SOP) based on the literature and Catphan 504 phantom and On-Board Imager manuals were drafted. The following SOPs were prepared: acquisition of CBCT image; CT number linearity; uniformity; spatial resolution; low contrast resolution; spatial linearity; slice thickness. The validation of the procedures from an experimental acquisition of the phantom was performed. The results, obtained in the SOP validation, are in accordance with the parameters established by the phantom manufacturer, as well as those obtained in the On-Board Imager device acceptance. (author)

  8. Elaboration and implementation of standard operational procedure for quality assurance of cone beam CT image in radiotherapy; Elaboracao e implementacao de procedimentos operacionais padrao para controle de qualidade da imagem CBCT em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Bonatto, Larisse N.; Estacio, Daniela R.; Lopes, Juliane S.; Sansson, Angela; Duarte, Lucas O.; Sbaraini, Patricia; Silva, Ana M. Marques da; Streck, Elaine E., E-mail: larisse.neumann@pucrs.br [Pontificia Universidade Catolica do Rio Grande do Sul (PUC-RS), Porto Alegre, RS (Brazil)

    2016-07-01

    The objective of this article is to present the implementation of the quality Control of Cone Beam Computed Tomography (CBCT) image, generated by the On-Board Imager, integrated with the linear accelerator Trilogy. Standard operating procedures (POPs) have been developed based on the literature and manuals of the simulator object Catphan 504 and the On-Board Imager. The following POPs were developed: acquisition of the CBCT image; linearity of CT number; uniformity; spatial resolution; low contrast resolution; spatial linearity; thickness of the cut. The validation of the elaborated procedures was done from an experimental acquisition of the simulator object. The results obtained in the validation of the POPs are in compliance with the parameters established by the manufacturer of the simulator object, as well as those obtained in the acceptance of the On-Board Imager device.

  9. Study of the heterogeneity effects of lung in the evaluation of absorbed dose in radiotherapy; Estudo dos efeitos da heterogeneidade de pulmao na avaliacao da dose absorvida em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Campos, Luciana Tourinho

    2006-02-15

    The main objective of radiotherapy is to deliver the highest possible dose to the tumour, in order to destroy it, reducing as much as possible the doses to healthy tissues adjacent to the target volume. Therefore, it is necessary to do a planning of the treatment. The more complex is the treatment, the more difficult the planning will be, demanding computation sophisticated methods in its execution, in order to consider the heterogeneities present in the human body. Additionally, with the appearing of new radiotherapeutic techniques, that used irradiation fields of small area, for instance, the intensity modulated radiotherapy, the difficulties for the execution of a reliable treatment planning, became still larger. In this work it was studied the influence of the lung heterogeneity in the planning of the curves of percentage depth dose, PDP, obtained with the Eclipse{sup R} planning system for different sizes of irradiation fields, using the correction algorithms for heterogeneities available in the planning system: modified Batho, general Batho and equivalent tissue-air ratio. A thorax phantom, manufactured in acrylic, containing a region made of cork to simulate the lung tissue, was used. The PDP curves generated by the planning system were compared to those obtained by Monte Carlo simulation and with the use of thermoluminescent, TL, dosimetry. It was verified that the algorithms used by the Eclipse{sup R} system for the correction of heterogeneity effects are not able to generate correct results for PDP curves in the case of small fields, occurring differences of up to 100%, when the 1x1 cm{sup 2} treatment field is considered. These differences can cause a considerable subdosage in the lung tissue, reducing the possibility of the patient cure. (author)

  10. Results of the implementation of a learning system with incidents in an radiotherapy department; Resultados da implementacao de um sistema de aprendizagem com incidentes em um Departamento de Radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Radicchi, Lucas Augusto; Vilela, Ellen Pedroso Severino; Faustino, Fabio de Lima C.; Rodrigues, Fernanda Arantes C.; Gomes, Franciele N.; Souza, Guilherme Vicente de; Silva, Rose Marta S. [Hospital de Cancer de Barretos, SP (Brazil); Toledo, Jose Carlos de [Universidade Federal de Sao Carlos (UFSCar), SP (Brazil)

    2016-07-01

    An incident learning system (ILS) is an important tool for improving aspects of patient and staff safety. In radiation oncology, ILS has been implemented both at the institutional level as at the national level, allowing to share lessons learned from incidents that have already occurred. The objective of this study is to present the preliminary results of the ILS implemented in a radiation oncology department. In total, 128 incidents were reviewed by a multidisciplinary committee, and the professional groups that registered more were medical physicists, radiation oncologists and radiation therapists. In addition, incidents have occurred and have been detected mainly in the treatment step. The incident learning system proved to be an important process improvement tool, according to the results shown,the improvement actions proposed and the perception of the people involved. (author)

  11. Development of a computational system based in the code GEANT4 for dosimetric evaluation in radiotherapy; Desenvolvimento de um sistema computacional baseado no Codigo GEANT4 para avaliacoes dosimetricas em radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Alex Cristovao Holanda de

    2016-10-01

    The incidence of cancer has grown in Brazil, as well as around the world, following the change in the age profile of the population. One of the most important techniques and commonly used in cancer treatment is radiotherapy. Around 60% of new cases of cancer use radiation in at least one phase of treatment. The most used equipment for radiotherapy is a linear accelerator (Linac) which produces electron or X-ray beams in energy range from 5 to 30 MeV. The most appropriate way to irradiate a patient is determined during treatment planning. Currently, treatment planning system (TPS) is the main and the most important tool in the process of planning for radiotherapy. The main objective of this work is to develop a computational system based on the MC code Geant4 for dose evaluations in photon beam radiotherapy. In addition to treatment planning, these dose evaluations can be performed for research and quality control of equipment and TPSs. The computer system, called Quimera, consists of a graphical user interface (qGUI) and three MC applications (qLinacs, qMATphantoms and qNCTphantoms). The qGUI has the function of interface for the MC applications, by creating or editing the input files, running simulations and analyzing the results. The qLinacs is used for modeling and generation of Linac beams (phase space). The qMATphantoms and qNCTphantoms are used for dose calculations in virtual models of physical phantoms and computed tomography (CT) images, respectively. From manufacturer's data, models of a Varian Linac photon beam and a Varian multileaf collimator (MLC) were simulated in the qLinacs. The Linac and MLC modelling were validated using experimental data. qMATphamtoms and qNCTphantoms were validated using IAEA phase spaces. In this first version, the Quimera can be used for research, radiotherapy planning of simple treatments and quality control in photon beam radiotherapy. The MC applications work independent of the qGUI and the qGUI can be used for handling CT images and analysis of results from other MC applications. Due to the modular structure of the Quimera, one can add new MC applications, allowing the development of new research for use of other techniques (electron beam, protons, heavy ions, tomotherapy, etc.) and applications (brachytherapy, radiation protection, etc.) in radiotherapy. Quimera is an initiative for collaborative development of a complete computer system that can be used in radiotherapy, for clinical and technical practice and research. (author)

  12. Magnetic resonance imaging in the evaluation of standard radiotherapy field borders in patients with uterine cervix cancer;Ressonancia magnetica para avaliacao dos limites dos campos classicos de radioterapia em pacientes portadoras de neoplasia maligna de colo uterino

    Energy Technology Data Exchange (ETDEWEB)

    Freire, Geison Moreira; Dias, Rodrigo Souza; Giordani, Adelmo Jose; Segreto, Helena Regina Comodo; Segreto, Roberto Araujo, E-mail: segreto.dmed@epm.b [Universidade Federal de Sao Paulo (UNIFESP-EPM), SP (Brazil). Unit of Radioterapy; Ribalta, Julisa Chamorro Lascasas [Universidade Federal de Sao Paulo (UNIFESP-EPM), SP (Brazil). Dept. de Gynecology

    2010-05-15

    Objective: to evaluate, by means of magnetic resonance imaging, the standardized field borders in radiotherapy for malignant neoplasm of uterine cervix, and to determine the role of this method in the reduction of possible planning errors related to the conventional technique. Materials and methods: magnetic resonance imaging studies for planning of treatment of 51 patients with uterine cervix cancer were retrospectively analyzed. The parameters assessed were the anterior and posterior field borders on sagittal section. Results: The anterior field border was inappropriate in 20 (39.2%) patients and geographic miss was observed in 37.3% of cases in the posterior border. The inappropriateness of both field borders did not correlate with clinical parameters such as patients' age, tumor staging, histological type and degree. Conclusion: the evaluation of standardized field borders with the use of magnetic resonance imaging has demonstrated high indices of inappropriateness of the lateral field borders, as well as the relevant role of magnetic resonance imaging in the radiotherapy planning for patients with uterine cervix cancer with a view to reduce the occurrence of geographic miss of the target volume. (author)

  13. Intercomparison of ionization chambers in standard X-ray beams, at radiotherapy, diagnostic radiology and radioprotection levels; Intercomparacao de camaras de ionizacao em feixes padroes de raios X, niveis radioterapia, radiodiagnostico e radioprotecao

    Energy Technology Data Exchange (ETDEWEB)

    Bessa, Ana Carolina Moreira de

    2006-07-01

    Since the calibration of radiation measurement instruments and the knowledge of their major characteristics are very important subjects, several different types of ionization chambers were intercompared in terms of their calibration coefficients and their energy dependence, in radiotherapy, diagnostic radiology and radioprotection standard beams. An intercomparison of radionuclide calibrators for nuclear medicine was performed, using three radionuclides: {sup 67}Ga, {sup 201}Tl and {sup 99m}Tc; the results obtained were all within the requirements of the national standard CNEN-NE-3.05. In order to complete the range of radiation qualities of the Calibration Laboratory of IPEN, standard radiation beam qualities, radiation protection and low energy radiation therapy levels, were established, according international recommendations. Three methodologies for the calibration of unsealed ionization chambers in X-ray beams were studied and compared. A set of Victoreen ionization chambers, specially designed for use in laboratorial intercomparisons, was submitted to characterization tests. The performance of these Victoreen ionization chambers showed that they are suitable for use in radioprotection beams, because the results obtained agree with international recommendations. However, these Victoreen ionization chambers can be used in radiotherapy and diagnostic radiology beams only with some considerations, since their performance in these beams, especially in relation to the energy dependence and stabilization time tests, did not agree with the international recommendations for dosimeters used in radiotherapy and diagnostic radiology beams. This work presents data on the performance of several types of ionization chambers in different X-ray beams, that may be useful for choosing the appropriate instrument for measurements in ionizing radiation beams. (author)

  14. Comparison of two heterogeneity correction algorithms in pituitary gland treatments with intensity-modulated radiation therapy; Comparacao de dois algoritmos de correcao de heterogeneidade em tratamentos de tumores de hipofise com radioterapia de intensidade modulada

    Energy Technology Data Exchange (ETDEWEB)

    Albino, Lucas D.; Santos, Gabriela R.; Ribeiro, Victor A.B.; Rodrigues, Laura N., E-mail: lucasdelbem1@gmail.com [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Faculdade de Medicina. Instituto de Radiologia; Weltman, Eduardo; Braga, Henrique F. [Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, SP (Brazil). Servico de Radioterapia

    2013-12-15

    The dose accuracy calculated by a treatment planning system is directly related to the chosen algorithm. Nowadays, several calculation doses algorithms are commercially available and they differ in calculation time and accuracy, especially when individual tissue densities are taken into account. The aim of this study was to compare two different calculation algorithms from iPlan®, BrainLAB, in the treatment of pituitary gland tumor with intensity-modulated radiation therapy (IMRT). These tumors are located in a region with variable electronic density tissues. The deviations from the plan with no heterogeneity correction were evaluated. To initial validation of the data inserted into the planning system, an IMRT plan was simulated in a anthropomorphic phantom and the dose distribution was measured with a radiochromic film. The gamma analysis was performed in the film, comparing it with dose distributions calculated with X-ray Voxel Monte Carlo (XVMC) algorithm and pencil beam convolution (PBC). Next, 33 patients plans, initially calculated by PBC algorithm, were recalculated with XVMC algorithm. The treatment volumes and organs-at-risk dose-volume histograms were compared. No relevant differences were found in dose-volume histograms between XVMC and PBC. However, differences were obtained when comparing each plan with the plan without heterogeneity correction. (author)

  15. Evaluation of the radiotherapy and/or therapeutical associations in prostate cancer using prostate specific antigen (PSA); Avaliacao da radioterapia e/ou associacoes terapeuticas em cancer de prostata atraves do antigeno prostatico especifico (PSA)

    Energy Technology Data Exchange (ETDEWEB)

    Cardoso, Isabel Cristina Rossiter de Araujo [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear]|[FUNED - Fundacao Ezequiel Dias, Belo Horizonte, MG (Brazil). Servico de Imunoquimica; Campos, Tarcisio Passos Ribeiro de [FUNED - Fundacao Ezequiel Dias, Belo Horizonte, MG (Brazil). Servico de Imunoquimica

    2002-07-01

    Novel statistics show that prostate cancer is the third mortality neoplasia type in man and reaches the first level after 75 years old. The disease appears without signal at initial stages of the prostate cancer, period at which it will be easily treated. The development of the prostate carcinoma in patients depends on the tumor histological degree, stage of the disease at the diagnostic time, tumoral mass, patient age and patient general health. The prostate specific antigen (PSA) is the tumor marker used to premature disease detection, stagement and patient monitoring after treatment. Distinct therapies or in association have been established, together with a premature diagnosis, to increase the patient survival, achieving the best health quality and disease heal. The applied gland dose and its profile are distinct between brachytherapy and teletherapy.The present paper describes several therapies applied to control the prostate tumors, standing radioactive implants (I{sup 125} ) and conventional radiotherapy. The goal of this paper is to show the different PSA levels resulting after radiation therapy, look upon tumor biology aspects, isodose profiles and serum PSA levels. (author)

  16. Lymphoreticular neoplasia after post-operating radiotherapy in epidermoid carcinoma of the palatine tonsil - a review; Neoplasia linforreticular apos radioterapia pos-operatoria em carcinoma epidermoide de tonsila-palatina: uma revisao

    Energy Technology Data Exchange (ETDEWEB)

    Franzi, S.A.; Amar, A.; Rapoport, A

    2004-07-01

    Surgery is the initial treatment of squamous cell carcinoma of the tonsillar region, followed by the indication of radiotherapy when the histological findings of the specimen show positive margins, vascular embolization, perineural infiltration or metastatic lymph node. However, the knowledge that patients with head and neck tumor who are treated with radiotherapy after surgery are at risk of developing a second primary lymphoreticular malignancy, such as leukemia is cause for concern among the specialists. Adverse effects of radiotherapy in patients with head and neck squamous cell carcinoma frequently result in chronic myeloid leukemia. The assessment of risks of radiotherapy-induced second primary tumors has been reported in many different epidemiological studies as well as the risk levels for different tissues, although the genetic studies are still infrequent in the world literature. (author)

  17. A new fundamental type of conformational isomerism

    Science.gov (United States)

    Canfield, Peter J.; Blake, Iain M.; Cai, Zheng-Li; Luck, Ian J.; Krausz, Elmars; Kobayashi, Rika; Reimers, Jeffrey R.; Crossley, Maxwell J.

    2018-06-01

    Isomerism is a fundamental chemical concept, reflecting the fact that the arrangement of atoms in a molecular entity has a profound influence on its chemical and physical properties. Here we describe a previously unclassified fundamental form of conformational isomerism through four resolved stereoisomers of a transoid (BF)O(BF)-quinoxalinoporphyrin. These comprise two pairs of enantiomers that manifest structural relationships not describable within existing IUPAC nomenclature and terminology. They undergo thermal diastereomeric interconversion over a barrier of 104 ± 2 kJ mol-1, which we term `akamptisomerization'. Feasible interconversion processes between conceivable synthesis products and reaction intermediates were mapped out by density functional theory calculations, identifying bond-angle inversion (BAI) at a singly bonded atom as the reaction mechanism. We also introduce the necessary BAI stereodescriptors parvo and amplo. Based on an extended polytope formalism of molecular structure and stereoisomerization, BAI-driven akamptisomerization is shown to be the final fundamental type of conformational isomerization.

  18. Radial expansion for spinning conformal blocks

    CERN Document Server

    Costa, Miguel S.; Penedones, João; Trevisani, Emilio

    2016-07-12

    This paper develops a method to compute any bosonic conformal block as a series expansion in the optimal radial coordinate introduced by Hogervorst and Rychkov. The method reduces to the known result when the external operators are all the same scalar operator, but it allows to compute conformal blocks for external operators with spin. Moreover, we explain how to write closed form recursion relations for the coefficients of the expansions. We study three examples of four point functions in detail: one vector and three scalars; two vectors and two scalars; two spin 2 tensors and two scalars. Finally, for the case of two external vectors, we also provide a more efficient way to generate the series expansion using the analytic structure of the blocks as a function of the scaling dimension of the exchanged operator.

  19. A probabilistic model of RNA conformational space

    DEFF Research Database (Denmark)

    Frellsen, Jes; Moltke, Ida; Thiim, Martin

    2009-01-01

    , the discrete nature of the fragments necessitates the use of carefully tuned, unphysical energy functions, and their non-probabilistic nature impairs unbiased sampling. We offer a solution to the sampling problem that removes these important limitations: a probabilistic model of RNA structure that allows...... conformations for 9 out of 10 test structures, solely using coarse-grained base-pairing information. In conclusion, the method provides a theoretical and practical solution for a major bottleneck on the way to routine prediction and simulation of RNA structure and dynamics in atomic detail.......The increasing importance of non-coding RNA in biology and medicine has led to a growing interest in the problem of RNA 3-D structure prediction. As is the case for proteins, RNA 3-D structure prediction methods require two key ingredients: an accurate energy function and a conformational sampling...

  20. Covariant Conformal Decomposition of Einstein Equations

    Science.gov (United States)

    Gourgoulhon, E.; Novak, J.

    It has been shown1,2 that the usual 3+1 form of Einstein's equations may be ill-posed. This result has been previously observed in numerical simulations3,4. We present a 3+1 type formalism inspired by these works to decompose Einstein's equations. This decomposition is motivated by the aim of stable numerical implementation and resolution of the equations. We introduce the conformal 3-``metric'' (scaled by the determinant of the usual 3-metric) which is a tensor density of weight -2/3. The Einstein equations are then derived in terms of this ``metric'', of the conformal extrinsic curvature and in terms of the associated derivative. We also introduce a flat 3-metric (the asymptotic metric for isolated systems) and the associated derivative. Finally, the generalized Dirac gauge (introduced by Smarr and York5) is used in this formalism and some examples of formulation of Einstein's equations are shown.

  1. A probabilistic model of RNA conformational space

    DEFF Research Database (Denmark)

    Frellsen, Jes; Moltke, Ida; Thiim, Martin

    2009-01-01

    efficient sampling of RNA conformations in continuous space, and with associated probabilities. We show that the model captures several key features of RNA structure, such as its rotameric nature and the distribution of the helix lengths. Furthermore, the model readily generates native-like 3-D......, the discrete nature of the fragments necessitates the use of carefully tuned, unphysical energy functions, and their non-probabilistic nature impairs unbiased sampling. We offer a solution to the sampling problem that removes these important limitations: a probabilistic model of RNA structure that allows......The increasing importance of non-coding RNA in biology and medicine has led to a growing interest in the problem of RNA 3-D structure prediction. As is the case for proteins, RNA 3-D structure prediction methods require two key ingredients: an accurate energy function and a conformational sampling...

  2. NMR spectroscopy: a tool for conformational analysis

    International Nuclear Information System (INIS)

    Tormena, Claudio F.; Cormanich, Rodrigo A.; Rittner, Roberto; Freitas, Matheus P.

    2011-01-01

    The present review deals with the application of NMR data to the conformational analysis of simple organic compounds, together with other experimental methods like infrared spectroscopy and with theoretical calculations. Each sub-section describes the results for a group of compounds which belong to a given organic function like ketones, esters, etc. Studies of a single compound, even of special relevance, were excluded since the main goal of this review is to compare the results for a given function, where different substituents were used or small structural changes were introduced in the substrate, in an attempt to disclose their effects in the conformational equilibrium. Moreover, the huge amount of data available in the literature, on this research field, imposed some limitations which will be detailed in the Introduction, but it can be reminded in advance that these limitations include mostly the period when these results were published. (author)

  3. Quantum critical phenomena and conformal invariance

    International Nuclear Information System (INIS)

    Zhe Chang.

    1995-05-01

    We show that the Abelian bosonization of continuum limit of the 1D Hubbard model corresponds to the 2D explicitly conformal invariant Gaussian model at weak coupling limit. A universality argument is used to extend the equivalence to an entire segment of the critical line of the strongly correlated electron system. An integral equation satisfied by the mapping function between critical lines of the 1D Hubbard model and 2D Gaussian model is obtained and then solved in some limiting cases. By making use of the fact that the free Hubbard system reduces to four fermions and each of them is related to a c = 1/2 conformal field theory, we present exactly the partition function of the Hubbard model on a finite 1D lattice. (author). 16 refs

  4. A proof of the conformal collider bounds

    Energy Technology Data Exchange (ETDEWEB)

    Hofman, Diego M. [Institute for Theoretical Physics, University of Amsterdam, Science Park 904, Postbus 94485, 1090 GL, Amsterdam (Netherlands); Li, Daliang [Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD 21218 (United States); Meltzer, David [Department of Physics, Yale University, New Haven, CT 06511 (United States); Poland, David [Department of Physics, Yale University, New Haven, CT 06511 (United States); School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540 (United States); Rejon-Barrera, Fernando [Institute for Theoretical Physics, University of Amsterdam, Science Park 904, Postbus 94485, 1090 GL, Amsterdam (Netherlands)

    2016-06-20

    In this paper, we prove that the “conformal collider bounds” originally proposed in http://dx.doi.org/10.1088/1126-6708/2008/05/012 hold for any unitary parity-preserving conformal field theory (CFT) with a unique stress tensor in dimensions d≥3. In particular this implies that the ratio of central charges for a unitary 4d CFT lies in the interval (31/18)≥(a/c)≥(1/3). For superconformal theories this is further reduced to (3/2)≥(a/c)≥(1/2). The proof relies only on CFT first principles — in particular, bootstrap methods — and thus constitutes the first complete field theory proof of these bounds. We further elaborate on similar bounds for non-conserved currents and relate them to results obtained recently from deep inelastic scattering.

  5. Conformable Self-Healing Ballistic Armor

    Science.gov (United States)

    2011-06-28

    public release, distribution unlimited 13. SUPPLEMENTARY NOTES Patent No: US 7,966,923 B2 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION...B2 5 Each unit of shell 10 of the ballistic annor of the subject invention further comprises fastening means 20 to attach each such shell IOta the...selectively affixing the conformable ballistic annor to the vehicle is a secure manner, both on a temporal)’ orpennanent basis. The ballistic

  6. Conformally compactified homogeneous spaces (Possible Observable Consequences)

    International Nuclear Information System (INIS)

    Budinich, P.

    1995-01-01

    Some arguments based on the possible spontaneous violation of the Cosmological Principles (represented by the observed large-scale structures of galaxies), the Cartan-geometry of simple spinors and on the Fock-formulation of hydrogen-atom wave-equation in momentum-space, are presented in favour of the hypothesis that space-time and momentum-space should be both conformally compactified and represented by the two four-dimensional homogeneous spaces of the conformal group, both isomorphic to (S 3 X S 1 )/Z 2 and correlated by conformal inversion. Within this framework, the possible common origin for the S0(4) symmetry underlying the geometrical structure of the Universe, of Kepler orbits and of the H-atom is discussed. On of the consequences of the proposed hypothesis could be that any quantum field theory should be naturally free from both infrared and ultraviolet divergences. But then physical spaces defined as those where physical phenomena may be best described, could be different from those homogeneous spaces. A simple, exactly soluble, toy model, valid for a two-dimensional space-time is presented where the conjecture conformally compactified space-time and momentum-space are both isomorphic to (S 1 X S 1 )/Z 2 , while the physical spaces are two finite lattice which are dual since Fourier transforms, represented by finite, discrete, sums may be well defined on them. Furthermore, a q-deformed SU q (1,1) may be represented on them if q is a root of unity. (author). 22 refs, 3 figs

  7. Conformal potential in N dimensions (N>1)

    Energy Technology Data Exchange (ETDEWEB)

    Barucchi, G [Turin Univ. (Italy). Ist. di Fisica; Istituto di Fisica Matematica dell' Universita, Torino (Italy); Istituto Nazionale di Fisica Nucleare, Turin (Italy))

    1977-07-21

    The conformal invariant model of de Alfaro, Fubini and Furlan is studied in the case of potential V(Q) = g/2Q/sup 2/(Q/sup 2/ = ..sigma..sub(i=1)sup(N) Qsub(i)sup(2), N>1). By means of the invariance under projective transformations and the rotation symmetry of the system in configuration space, explicit solutions are obtained.

  8. Boundary conditions in conformal and integrable theories

    CERN Document Server

    Petkova, V B

    2000-01-01

    The study of boundary conditions in rational conformal field theories is not only physically important. It also reveals a lot on the structure of the theory ``in the bulk''. The same graphs classify both the torus and the cylinder partition functions and provide data on their hidden ``quantum symmetry''. The Ocneanu triangular cells -- the 3j-symbols of these symmetries, admit various interpretations and make a link between different problems.

  9. Conformal mechanics in Newton-Hooke spacetime

    International Nuclear Information System (INIS)

    Galajinsky, Anton

    2010-01-01

    Conformal many-body mechanics in Newton-Hooke spacetime is studied within the framework of the Lagrangian formalism. Global symmetries and Noether charges are given in a form convenient for analyzing the flat space limit. N=2 superconformal extension is built and a new class on N=2 models related to simple Lie algebras is presented. A decoupling similarity transformation on N=2 quantum mechanics in Newton-Hooke spacetime is discussed.

  10. Pyrrolidine nucleotide analogs with a tunable conformation

    Czech Academy of Sciences Publication Activity Database

    Poštová Slavětínská, Lenka; Rejman, Dominik; Pohl, Radek

    2014-01-01

    Roč. 10, Aug 22 (2014), s. 1967-1980 ISSN 1860-5397 R&D Projects: GA ČR GA13-24880S Institutional support: RVO:61388963 Keywords : conformation * NMR * nucleic acids * nucleotide analog * phosphonic acid * pseudorotation * pyrrolidine Subject RIV: CC - Organic Chemistry Impact factor: 2.762, year: 2014 http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-10-205

  11. Spacelike conformal Killing vectors and spacelike congruences

    International Nuclear Information System (INIS)

    Mason, D.P.; Tsamparlis, M.

    1985-01-01

    Necessary and sufficient conditions are derived for space-time to admit a spacelike conformal motion with symmetry vector parallel to a unit spacelike vector field n/sup a/. These conditions are expressed in terms of the shear and expansion of the spacelike congruence generated by n/sup a/ and in terms of the four-velocity of the observer employed at any given point of the congruence. It is shown that either the expansion or the rotation of this spacelike congruence must vanish if Dn/sup a//dp = 0, where p denotes arc length measured along the integral curves of n/sup a/, and also that there exist no proper spacelike homothetic motions with constant expansion. Propagation equations for the projection tensor and the rotation tensor are derived and it is proved that every isometric spacelike congruence is rigid. Fluid space-times are studied in detail. A relation is established between spacelike conformal motions and material curves in the fluid: if a fluid space-time admits a spacelike conformal Killing vector parallel to n/sup a/ and n/sub a/u/sup a/ = 0, where u/sup a/ is the fluid four-velocity, then the integral curves of n/sup a/ are material curves in an irrotational fluid, while if the fluid vorticity is nonzero, then the integral curves of n/sup a/ are material curves if and only if they are vortex lines. An alternative derivation, based on the theory of spacelike congruences, of some of the results of Collins [J. Math. Phys. 25, 995 (1984)] on conformal Killing vectors parallel to the local vorticity vector in shear-free perfect fluids with zero magnetic Weyl tensor is given

  12. Group Cohesiveness, Deviation, Stress, and Conformity

    Science.gov (United States)

    1993-08-11

    Cola number of cups, __ Chocolate, cocoa, wine, beer/ alcohol , decaffeinated coffee. Breads containing raisins, prunes, orange peel , banana , or...conforming in order to get the group to accept them. In a study using a similar procedure, Kiesler and Corbin (1965) found that commitment to continue as...second lession, we’ll have subjects actually interact in a group problem solving task , so you’ll get a first hand view of each other’s ways of

  13. Determinantes do Nível de Conformidade das Evidenciações Relativas ao CPC 27 em Empresas do Novo Mercado da Bm&Fbovespa = Determinants of the Conformity Level of Evidences Related to the Disclosure CPC 27 in Companies of the New BM&FBOVESPA Market

    Directory of Open Access Journals (Sweden)

    Itzhak David Simão Kaveski

    2015-04-01

    Full Text Available O presente artigo tem por objetivo identificar os fatores que explicam o nível de divulgação relativo ao CPC 27 – Ativo Imobilizado, por empresas listadas no segmento do Novo Mercado de Governança Corporativa da BM&FBovespa, considerando como seus prováveis determinantes as variáveis tamanho, imobilizado total, endividamento e rentabilidade do imobilizado. O estudo caracteriza-se como descritivo, conduzido por meio de análise documental e abordagem quantitativa. A população é composta de 109 empresas em 2011, abrangendo uma amostra de 106 empresas. Para coleta dos dados foi elaborado um check list composto de 17 itens baseados no Pronunciamento Técnico CPC 27. A técnica de análise, buscando alcançar a proposta de pesquisa, deu-se por meio de regressão linear múltipla. Nos resultados encontrados, verificou-se uma relação positiva significativa entre o ativo imobilizado das empresa e o índice de evidenciação, verificado pelos itens correspondentes aos requisitos mencionados no CPC 27. No que tange às variáveis determinantes do processo de evidenciação, verificou-se que “Imobilizado” está positivamente associado à divulgação de informações sobre ativo imobilizado. Já a “Rentabilidade” está negativamente associada à divulgação. Não se verificou associação significante entre “Endividamento” e “Tamanho” com a divulgação de informações sobre imobilizado. É necessário considerar, ainda, o baixo fator explicativo das variáveis determinantes da evidenciação recomendada pelo CPC 27 e a necessidade de se estender a investigação dentro do tema, possibilitando comparações e extração de novas evidências conclusivas. This article aims at identifying the factors that explain the level of disclosure concerning the CPC 27 - Fixed Assets, for companies listed on the New Market segment of Corporate Governance of BM&FBovespa. The probable determinants are considered the size variations, the

  14. EM International. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    It is the intent of EM International to describe the Office of Environmental Restoration and Waste Management`s (EM`s) various roles and responsibilities within the international community. Cooperative agreements and programs, descriptions of projects and technologies, and synopses of visits to international sites are all highlighted in this semiannual journal. Focus on EM programs in this issue is on international collaboration in vitrification projects. Technology highlights covers: in situ sealing for contaminated sites; and remote sensors for toxic pollutants. Section on profiles of countries includes: Arctic contamination by the former Soviet Union, and EM activities with Germany--cooperative arrangements.

  15. Rényi entropy and conformal defects

    International Nuclear Information System (INIS)

    Bianchi, Lorenzo; Meineri, Marco; Myers, Robert C.; Smolkin, Michael

    2016-01-01

    We propose a field theoretic framework for calculating the dependence of Rényi entropies on the shape of the entangling surface in a conformal field theory. Our approach rests on regarding the corresponding twist operator as a conformal defect and in particular, we define the displacement operator which implements small local deformations of the entangling surface. We identify a simple constraint between the coefficient defining the two-point function of the displacement operator and the conformal weight of the twist operator, which consolidates a number of distinct conjectures on the shape dependence of the Rényi entropy. As an example, using this approach, we examine a conjecture regarding the universal coefficient associated with a conical singularity in the entangling surface for CFTs in any number of spacetime dimensions. We also provide a general formula for the second order variation of the Rényi entropy arising from small deformations of a spherical entangling surface, extending Mezei’s results for the entanglement entropy.

  16. Compact conformations of human protein disulfide isomerase.

    Directory of Open Access Journals (Sweden)

    Shang Yang

    Full Text Available Protein disulfide isomerase (PDI composed of four thioredoxin-like domains a, b, b', and a', is a key enzyme catalyzing oxidative protein folding in the endoplasmic reticulum. Large scale molecular dynamics simulations starting from the crystal structures of human PDI (hPDI in the oxidized and reduced states were performed. The results indicate that hPDI adopts more compact conformations in solution than in the crystal structures, which are stabilized primarily by inter-domain interactions, including the salt bridges between domains a and b' observed for the first time. A prominent feature of the compact conformations is that the two catalytic domains a and a' can locate close enough for intra-molecular electron transfer, which was confirmed by the characterization of an intermediate with a disulfide between the two domains. Mutations, which disrupt the inter-domain interactions, lead to decreased reductase activity of hPDI. Our molecular dynamics simulations and biochemical experiments reveal the intrinsic conformational dynamics of hPDI and its biological impact.

  17. Deep Inelastic Scattering in Conformal QCD

    CERN Document Server

    Cornalba, Lorenzo; Penedones, Joao

    2010-01-01

    We consider the Regge limit of a CFT correlation function of two vector and two scalar operators, as appropriate to study small-x deep inelastic scattering in N=4 SYM or in QCD assuming approximate conformal symmetry. After clarifying the nature of the Regge limit for a CFT correlator, we use its conformal partial wave expansion to obtain an impact parameter representation encoding the exchange of a spin j Reggeon for any value of the coupling constant. The CFT impact parameter space is the three-dimensional hyperbolic space H3, which is the impact parameter space for high energy scattering in the dual AdS space. We determine the small-x structure functions associated to the exchange of a Reggeon. We discuss unitarization from the point of view of scattering in AdS and comment on the validity of the eikonal approximation. We then focus on the weak coupling limit of the theory where the amplitude is dominated by the exchange of the BFKL pomeron. Conformal invariance fixes the form of the vector impact factor a...

  18. Implications of conformal invariance in momentum space

    Science.gov (United States)

    Bzowski, Adam; McFadden, Paul; Skenderis, Kostas

    2014-03-01

    We present a comprehensive analysis of the implications of conformal invariance for 3-point functions of the stress-energy tensor, conserved currents and scalar operators in general dimension and in momentum space. Our starting point is a novel and very effective decomposition of tensor correlators which reduces their computation to that of a number of scalar form factors. For example, the most general 3-point function of a conserved and traceless stress-energy tensor is determined by only five form factors. Dilatations and special conformal Ward identities then impose additional conditions on these form factors. The special conformal Ward identities become a set of first and second order differential equations, whose general solution is given in terms of integrals involving a product of three Bessel functions (`triple- K integrals'). All in all, the correlators are completely determined up to a number of constants, in agreement with well-known position space results. In odd dimensions 3-point functions are finite without renormalisation while in even dimensions non-trivial renormalisation in required. In this paper we restrict ourselves to odd dimensions. A comprehensive analysis of renormalisation will be discussed elsewhere. This paper contains two parts that can be read independently of each other. In the first part, we explain the method that leads to the solution for the correlators in terms of triple- K integrals while the second part contains a self-contained presentation of all results. Readers interested only in results may directly consult the second part of the paper.

  19. Boundary conditions in rational conformal field theories

    International Nuclear Information System (INIS)

    Behrend, Roger E.; Pearce, Paul A.; Petkova, Valentina B.; Zuber, Jean-Bernard

    2000-01-01

    We develop further the theory of Rational Conformal Field Theories (RCFTs) on a cylinder with specified boundary conditions emphasizing the role of a triplet of algebras: the Verlinde, graph fusion and Pasquier algebras. We show that solving Cardy's equation, expressing consistency of a RCFT on a cylinder, is equivalent to finding integer valued matrix representations of the Verlinde algebra. These matrices allow us to naturally associate a graph G to each RCFT such that the conformal boundary conditions are labelled by the nodes of G. This approach is carried to completion for sl(2) theories leading to complete sets of conformal boundary conditions, their associated cylinder partition functions and the A-D-E classification. We also review the current status for WZW sl(3) theories. Finally, a systematic generalisation of the formalism of Cardy-Lewellen is developed to allow for multiplicities arising from more general representations of the Verlinde algebra. We obtain information on the bulk-boundary coefficients and reproduce the relevant algebraic structures from the sewing constraints

  20. Rényi entropy and conformal defects

    Energy Technology Data Exchange (ETDEWEB)

    Bianchi, Lorenzo [Institut für Physik, Humboldt-Universität zu Berlin,Zum Großen Windkanal 6, 12489 Berlin (Germany); II. Institut für Theoretische Physik, Universität Hamburg,Luruper Chaussee 149, 22761 Hamburg (Germany); Meineri, Marco [Scuola Normale Superiore and Istituto Nazionale di Fisica Nucleare - Sezione di Pisa,Piazza dei Cavalieri 7, I-56126 Pisa (Italy); Perimeter Institute for Theoretical Physics,31 Caroline Street North, Waterloo, ON N2L 2Y5 (Canada); Myers, Robert C. [Perimeter Institute for Theoretical Physics,31 Caroline Street North, Waterloo, ON N2L 2Y5 (Canada); Smolkin, Michael [Center for Theoretical Physics, Department of Physics, University of California,Berkeley, CA 94720 (United States)

    2016-07-14

    We propose a field theoretic framework for calculating the dependence of Rényi entropies on the shape of the entangling surface in a conformal field theory. Our approach rests on regarding the corresponding twist operator as a conformal defect and in particular, we define the displacement operator which implements small local deformations of the entangling surface. We identify a simple constraint between the coefficient defining the two-point function of the displacement operator and the conformal weight of the twist operator, which consolidates a number of distinct conjectures on the shape dependence of the Rényi entropy. As an example, using this approach, we examine a conjecture regarding the universal coefficient associated with a conical singularity in the entangling surface for CFTs in any number of spacetime dimensions. We also provide a general formula for the second order variation of the Rényi entropy arising from small deformations of a spherical entangling surface, extending Mezei’s results for the entanglement entropy.