WorldWideScience

Sample records for em boston eua

  1. A organização dos imigrantes brasileiros em Boston, EUA

    OpenAIRE

    Sales, Teresa [UNESP

    2005-01-01

    This paper discusses the progress of the Brazilian migrants' organization in the metropolitan area of Boston, in the United States. Based on a research done in October of 2005, it presents several organizations created by the Brazilian migrants between 1995 and 2005, in the cities of Framingham, Boston, Somerville and Cambridge. It concludes that the Brazilians improved their political organization, as a consequence of the cultural background of some leaders, than in the service sector. O ...

  2. Significant contributing causes of cancer deaths among Hispanics in Colorado, USA, 1983-1992 Causas que contribuem para óbitos por câncer em latinos no Colorado, EUA, 1983-92

    Directory of Open Access Journals (Sweden)

    Kimberley Sweitzer

    1998-01-01

    Full Text Available Cancer deaths in the state of Colorado, U.S.A., totaled 53,921 between 1983 and 1992. Death certificates for this period were used to evaluate Hispanic cancer deaths by contributing causes of death and primary occupation of the decedent. The relative risks for diabetes and liver disease as contributing causes of death were significantly higher among Hispanics when compared to non-Hispanics who had also died of cancer (RR for diabetes = 1.90; 95% C.I. (1.64,2.19 and RR for liver disease = 1.44; 95% C.I. (1.23,1.68. Hispanics who had died of cancer were significantly less likely to have drug abuse as a contributing cause of death when compared to non-Hispanics (RR for drug abuse = 0.69; 95% C.I. (0.52,0.91. Laborers, service workers, and clerical workers who were Hispanic, were significantly more likely to die of cancer with either diabetes or liver disease as a contributing cause of death than were non-Hispanics in the same occupational category (pEntre 1983 e 1997, ocorreram 53.921 óbitos por câncer no Estado do Colorado, EUA. Os atestados de óbito para este período foram utilizados para avaliar as causas que contribuíram para a morte e a ocupação principal dos óbitos por câncer ocorridos em latinos neste período. Os riscos relativos para diabetes e doença hepática como causas associadas ao óbito foram significativamente maiores em latinos, comparativamente com não latinos que também faleceram com câncer (diabetes RR = 1,90; I.C. 95% 1,64-2,19; doença hepática RR = 1,44; I.C. 95% 1,23-1,68. O consumo de drogas como causa associada à morte entre latinos que faleceram por câncer aparentou ser significativamente menor que em não latinos (RR = 0,69; I.C. 95% 0,52-0,91. Operários, servidores públicos e trabalhadores de escritório de origem latina tenderam a apresentar diabetes e doença hepática como causas associadas à morte por câncer em maior freqüência, estatisticamente significativa, que não latinos nos mesmos ramos

  3. UM ESTUDO SOBRE O VALOR DO SISTEMA DE RASTREABILIDADE ANIMAL NOS EUA

    OpenAIRE

    Resende Filho, Moises de Andrade

    2006-01-01

    Esse artigo investiga o valor do sistema nacional de identificação animal (NAIS) a ser implantado nos EUA. Assume-se que os benefícios para o setor de carnes nos EUA virão como conseqüência do efeito do NAIS sobre a percepção do consumidor final em relação ao risco de consumir carne e derivados impróprios para consumo. Sistemas de demanda dos tipos “generalized almost ideal” (GAI) e “generalized quadratic almost ideal” (GQUAIDS) foram estimados incorporando-se índices de reportagens negativa...

  4. Feito nos EUA: Os Sopranos

    OpenAIRE

    Terry Caesar

    2013-01-01

    Relato da experiência pessoal do próprio autor assistindo "The Sopranos" em três países diferentes, este ensaio discute o fenômeno da série de televisão, que foi ao ar por oito temporadas e se tornou um marco da cultura popular do mundo.

  5. A crise da potência inteligente: os EUA e a grande estratégia de acomodação no governo Obama

    Directory of Open Access Journals (Sweden)

    Diego Santos Vieira de Jesus

    2014-06-01

    Full Text Available Os objetivos do artigo são explicar (i a adoção da grande estratégia de acomodação, pelos Estados Unidos da América (EUA, durante a administração de Barack Obama, para lidar com as principais ameaças a tal Estado no nível internacional e (ii examinar os efeitos da crise econômico-financeira internacional iniciada em 2008 sobre a atuação internacional dos EUA. Foi desenvolvido, a partir da perspectiva analítica de Joseph S. Nye Jr. acerca do conceito de "poder inteligente", um estudo qualitativo no qual se buscou sustentar três argumentos centrais: (i a adoção da grande estratégia de acomodação mostrou-se relacionada ao conceito de "poder inteligente" que informa as posições da administração Obama; (ii a crise não provocou um desafio fundamental à posição predominante dos EUA no sistema internacional, mas confirmou a necessidade de reajuste da grande estratégia de tal Estado na direção da acomodação dos interesses de grandes potências, economias emergentes e Estados hostis aos EUA; (iii o reajuste da grande estratégia norte-americana não atingiu plenamente os resultados almejados por tal administração em face da cooperação limitada por parte de outras grandes potências, economias emergentes e Estados hostis aos EUA. As principais conclusões apontam que os EUA podem reforçar sua posição de "potência inteligente" se investirem mais em bens públicos globais, oferecendo o que povos e governos ao redor do mundo desejam, mas não conseguem sozinhos. Ao complementarem seu poder militar e econômico com um investimento maior em seu poder brando, os EUA poderiam reconstruir a estrutura necessária para lidar com desafios globais.

  6. Reações dos consumidores a falhas de serviços: um estudo no Brasil e EUA

    OpenAIRE

    Matos, Celso Augusto de; Garrido, Ivan Lapuente; D’Ávila, Lívia Castro; Calixto, Cyntia Vilasboas

    2012-01-01

    Apesar das pesquisas sobre falhas e recuperação de serviços, há poucos estudos investigando o efeito de diferenças culturais. Com base na revisão da literatura, foi proposto um modelo teórico, testado em dados de uma survey realizada junto a 260 consumidores do Brasil e EUA. Os resultados mostraram que a dimensão interpessoal da justiça percebida foi a mais importante para explicar a satisfação do consumidor, que por sua vez influenciou mais fortemente a intenção de reclamar junto a amigos...

  7. Potenciais benefícios do sistema de rastreabilidade animal dos EUA para o setor de carnes americano

    OpenAIRE

    Resende Filho, Moisés de Andrade

    2008-01-01

    Este artigo investigou os potenciais ganhos do setor de carnes americano advindos da implantação do Sistema Nacional de Identificação Animal (NAIS), dos EUA. Foram analisados os potenciais efeitos do NAIS sobre a percepção de risco dos consumidores americanos em relação aos perigos decorrentes do consumo das carnes bovina, suína e de aves e seus derivados. Sistemas de equações de demanda foram estimados, incorporando-se como "proxies" da percepção de risco do consumidor, séries de índices de ...

  8. Alfabetização visual de jovens imigrantes brasileiros nos EUA

    Directory of Open Access Journals (Sweden)

    João Kulcsár

    2006-08-01

    Full Text Available ESTE ARTIGO enfoca o uso da alfabetização visual como ferramenta para discutir a questão da imigração com jovens brasileiros não-documentados, moradores na região de Boston, Estados Unidos. Por meio do projeto "Identidades: rupturas & permanências", desenvolvido na Universidade de Harvard, os alunos expressaram por fotografias a atual situação em que se encontram.THIS ARTICLE focuses on the use of visual literacy as a tool to analyse the question of immigration with young undocumented Brazilians, living in the Boston area of the United States. In the project "Identities: Ruptures & Permanence", developed in the University of Harvard, they expressed their current situation through the use of Photographs.

  9. Cunard in Boston

    Directory of Open Access Journals (Sweden)

    Bradford T. Hudson

    2015-02-01

    Full Text Available The steamship Britannia arrived in Boston Harbor on a July evening in 1840. This concluded the inaugural voyage for the flagship of the newly established Cunard Line, which has since become one of the oldest and most distinguished travel companies in the world. To commemorate the occasion, Cunard will send its current flagship Queen Mary 2 along the same route – from Liverpool to Halifax to Boston – during July of 2015.

  10. Cunard in Boston

    OpenAIRE

    Bradford T. Hudson

    2015-01-01

    The steamship Britannia arrived in Boston Harbor on a July evening in 1840. This concluded the inaugural voyage for the flagship of the newly established Cunard Line, which has since become one of the oldest and most distinguished travel companies in the world. To commemorate the occasion, Cunard will send its current flagship Queen Mary 2 along the same route – from Liverpool to Halifax to Boston – during July of 2015.

  11. A gramática política das agências reguladoras : comparação entre o Brasil e EUA

    OpenAIRE

    Ramalho, Pedro Ivo Sebba

    2007-01-01

    Esta tese estuda as agências reguladoras brasileiras em comparação com o modelo regulatório dos EUA. O objetivo foi relacionar o conceito de gramáticas políticas ao desenho institucional e à prática regulatória das agências reguladoras brasileiras para investigar se a criação das agências reguladoras representou mudança na estrutura institucional brasileira. Inicialmente discute-se o neoinstitucionalismo nas ciências sociais, com ênfase no neo-institucionalismo histórico. As gramáticas pol...

  12. HR4EU--A Web-Portal for E-Learning of Croatian

    Science.gov (United States)

    Filko, Matea; Farkaš, Daša; Hriberski, Diana

    2016-01-01

    In this paper, we present the HR4EU--a web portal for e-learning of Croatian. HR4EU is the first portal that offers Croatian language courses which are free-of-charge and developed by language professionals. Moreover, HR4EU also integrates bidirectional interaction with some of the previously developed language resources for Croatian. The HR4EU…

  13. Com amigos assim, quem precisa de inimigos? Dois neo-realistas reduzem a amizade entre os EUA e Israel ao tráfico de influência

    Directory of Open Access Journals (Sweden)

    Peter Demant

    2006-11-01

    Full Text Available Em resposta ao artigo "O Lobby de Israel", sustenta-se que a proximidade entre os EUA e Israel é cultivada pelo Lobby e não por ele criada. Defende-se também que as conclusões de Mearsheimer e Walt são baseadas em pesquisa descuidada, deturpações e lógica falsa, mas que ainda assim a tese central é digna de debate.In response to the article "The Israel Lobby", this essay states that proximity between USA and Israel is cultivated by the Lobby, not created by it. It is also argued that Mearsheimer and Walt's conclusions are based on poor research, debasement and false logics, but that its main argument deserves serious debate.

  14. [The Boston keratoprosthesis].

    Science.gov (United States)

    Wang, Liqiang; Huang, Yifei; James, Chodosh; Dohlman, Claes H

    2014-04-01

    The Boston Keratoprosthesis (KPro) is one of several types of artificial cornea manufactured worldwide that are being implanted in increasing numbers in patients with severe corneal diseases and graft failures. To summerize the advances in design of the Boston type I keratoprosthesis and in the treatment strategies to conquer the post operative complications have expanded the indications and application of this technology. Many modifications to the design of the Boston type I keratoprosthesis and treatment of the patient in the post operative period have occurred. Also, the technology has been more widely accepted as a primary surgical option for patients with a poor preoperative prognosis for traditional penetrating keratoplasty. The outcomes of visual acuity, retention, and post-operative infection rates have all significantly improved since the technology has been modified and offers patients an alternative for visual rehabilitation. This is implanted into a carrier corneal graft or into the patient's own cornea. The allograft cornea can be the carrier, which may solve the shortage of donor cornea in China.

  15. Boston Collaborative Drug Surveillance Program

    Science.gov (United States)

    The Boston Collaborative Drug Surveillance Program started in 1966 and conducted epidemiologic research to quantify the potential adverse effects of prescription drugs, utilizing in-hospital monitoring.

  16. Regulamentação da internet: perspectiva comparada entre Brasil, Chile, Espanha, EUA e França

    Directory of Open Access Journals (Sweden)

    Rosemary Segurado

    2014-01-01

    Full Text Available A governança global ocupa lugar privilegiado na agenda de debates sobre o funcionamento da rede mundial de computadores, e o Brasil assumiu um papel de destaque nesse processo, principalmente após a aprovação do Marco Civil da Internet (lei n.12.965, de 23 de abril de 2014, que contém princípios, garantias, direitos e deveres para internautas e provedores no país. O estudo comparado foi desenvolvido a partir da seleção de categorias consideradas fundamentais para a análise: a neutralidade de rede, o direito à privacidade dos cidadãos internautas e a discussão sobre direitos autorais sob a lógica da propriedade intelectual. Foram esses os aspectos centrais que utilizamos para a análise das regulamentações em cinco países, Brasil, Chile, Espanha, EUA e França.

  17. Remesas y Ahorro de los Migrantes Michoacanos radicados en EUA. Un Diagnóstico Preliminar

    Directory of Open Access Journals (Sweden)

    Jerjes Aguirre Ochoa

    2007-06-01

    Full Text Available El objetivo de este artículo es realizar un diagnostico del potencial productivo del ahorro migrante para el caso del estado de Michoacán. Los datos obtenidos muestran un perfil de Michoacano radicado en EUA con ingresos suficientes para enviar remesas familiares a México pero limitados para realizar inversiones mayores a 200 dólares mensuales en Michoacán. Dentro de esa limitación, de contar con capital, los michoacanos manifestaron una preferencia por invertir en México y específicamente en su comunidad de origen. La preferencia de inversión mas citada es la compra de una vivienda o reparación de la misma. Asimismo, la corrupción y la inseguridad son señaladas como obstáculos para la inversión en México. Finalmente, el alto porcentaje de migrantes indocumentados encontrados en la encuesta refleja los profundos impactos que una reforma migratoria en EUA puede tener en la dinámica económica del estado. La migración a EUA puede dejar de convertirse en la válvula de escape para la población michoacana que no encuentre oportunidades laborales en Michoacán sumiendo a la entidad en graves problemas económicos y sociales.

  18. Boston Washer Study

    Energy Technology Data Exchange (ETDEWEB)

    Tomlinson, J.J.

    2002-08-06

    To help understand the relative performance gains of conventional and high-efficiency washers and to increase awareness of energy/water savings, the U.S. Department of Energy under its Emerging Technologies Program and in cooperation with Maytag Appliances conducted a field-evaluation of horizontal axis washers in a Boston, Massachusetts condo complex. Baseline washer and dryer performance and customer habits were established using 50 participants and their existing, instrumented washers and dryers for a 2 1/2-month period. After the baseline was established, the machines were replaced with high efficiency tumble action washers and moisture sensing dryers, and tested for the next 2 1/2 months. By information gathered, energy and water savings delivered by the h-axis washers as well as impacts on participants' washing habits and perceptions of cleaning performance were determined. Overall, participants saved 41% of the water and 50% of the energy that they would have used without a changeover to the new h-axis washer. The changeover also produced significant dryer energy savings due primarily to the high-speed final spin of the new washer. The Boston Washer Study report details the experiment including instrumentation, data collection and analysis procedures and discusses the impacts on energy, water and detergent consumption as well as customer satisfaction with the technology.

  19. A China na transição do sistema mundial : suas relações com EUA e Índia

    OpenAIRE

    Diego Pautasso

    2006-01-01

    O objetivo deste trabalho é discutir a ascensão internacional da China e suas relações com a Índia e os EUA. O argumento central é o de que a China está se tornando o centro gravitacional da ÁsiaPacífico, região que está assumindo a dianteira na 3ª Revolução Industrial, e, por sua vez, do processo de transição em curso no sistema mundial. A ascensão da China é parte de um longo ciclo de incorporação do país ao moderno sistema mundial, que inicialmente se processou de forma subordinada, por in...

  20. A bilionária indústria da educação médica continuada nos EUA: mais uma forma de interferência das empresas na relação médico-paciente

    Directory of Open Access Journals (Sweden)

    Mônica Teixeira

    2009-12-01

    Full Text Available O artigo trata de mais uma das formas pelas quais a indústria impacta a clínica médica. A indústria farmacêutica e de dispositivos médicos financia atividades de Educação Médica Continuada com o objetivo de promover a utilização de tratamentos que a ela interessam. A Educação Médica Continuada é obrigatória em muitos estados dos EUA para a renovação da licença para o exercício de profissões médicas e para-médicas. O congresso dos EUA discute como regular a questão, no contexto da reforma do sistema de saúde posta em discussão pelo atual presidente do país.

  1. ESTUDO DOS ÍNDICES EXTREMOS DE TEMPERATURA NA BACIA HIDROGRÁFICA DO BAIXO RIO COLORADO - EUA

    Directory of Open Access Journals (Sweden)

    Fabiane Regina da Cunha Dantas Araújo

    2015-03-01

    Full Text Available O aquecimento global vem sendo assunto constante em toda parte do planeta. Essa elevação na temperatura atmosférica pode gerar uma série de complicações sociais, econômicas e ambientais. Dessa forma, esta pesquisa objetiva analisar as tendências dos índices de extremos climáticos anuais, dependentes da temperatura na região da Bacia Hidrográfica do Baixo Rio Colorado situada no sudoeste dos EUA, e com isso investigar os possíveis impactos da variabilidade climática recente sobre a área de estudo no período de 1970 a 2009. Os dados de temperatura foram obtidos de 81 estações meteorológicas distribuídas na região da Bacia Hidrográfica do Baixo Rio Colorado, compreendendo os estados americanos do Arizona, Califórnia, Nevada, parte sudoeste do Novo México e parte sudoeste de Utah. Utilizou-se o software RClimdex no cálculo dos índices extremos de temperatura do ar. Dos índices climáticos de temperatura analisados, verificou-se que o índice Dias de Verão (DV contribuiu para dias mais quentes na região de estudo. O índice Noites Tropicais (NT mostrou aumento dos dias com temperatura mínima maior que 20° C. O número de dias frio e os valores mínimos das temperaturas máxima e mínima aumentaram. Por outro lado, o valor máximo da temperatura máxima não indicou um padrão de tendência com significância estatística.

  2. Shared-Ride Taxi Service in Boston, MA

    Science.gov (United States)

    1985-03-01

    This report presents an evaluation of the Boston Shared-Ride Taxi Demonstration. The City of Boston's Traffic and Parking Department, the project grantee, designed a shared-ride service for Boston's Allston-Brighton neighborhood; Boston Cab Associati...

  3. Ensino de Administração nos EUA e no Brasil: uma Análise Histórica

    Directory of Open Access Journals (Sweden)

    Aline Lourenço Oliveira

    2015-05-01

    Full Text Available Os cursos de administração aumentaram em número e são procurados por muitos estudantes. Essa expansão quantitativa trouxe em seu bojo muitas críticas, entre elas, a falta de correspondência entre a expansão e a qualidade do ensino. No entanto, entende-se que muitos dos problemas enfrentados pelo ensino de administração, atualmente, são decorrentes da forma como os cursos foram constituídos. Por isso, o objetivo deste ensaio teórico é compreender as particularidades do atual cenário educacional da área de Administração no país, por meio do resgate histórico da ascensão e da crise do ensino de administração nos EUA e no Brasil. Como resultado, evidencia-se problemas comuns aos dois países tais como a mercantilização da educação. As particularidades nacionais evidenciam fragilidades no ensino que comprometem a formação do administrador e denotam uma falta de perspectiva deste campo de formação profissional.

  4. Amando de olhos abertos: Emma Goldman e o dissenso político nos EUA Loving with open eyes: Emma Goldman and the political dissent in the Unites States

    Directory of Open Access Journals (Sweden)

    Cecilia Azevedo

    2007-12-01

    Full Text Available Este artigo apresenta a trajetória de Emma Goldman, grande nome do anarquismo, pacifismo e feminismo nos EUA, procurando apresentá- la como uma representante da chamada tradição de dissenso neste país que, ao longo de toda sua história, tem disputado os sentidos a serem atribuídos aos ideais nacionais. Em meio à atual guerra no Iraque, a memória e o legado de Emma Goldman vêm sendo recuperados no embate político em torno do sentido do americanismo.This article presents the life of Emma Goldman, who played a central role in the history of anarchism, pacifism and feminism in the United States. In the present days, when a new war is taking place in Iraq, the memory and legacy of Emma Goldman are being reassessed amidst the debate over the political meaning of Americanism.

  5. 77 FR 50916 - Safety Zone; Boston Harbor's Rock Removal Project, Boston Inner Harbor, Boston, MA

    Science.gov (United States)

    2012-08-23

    ...) Zone for the drilling, blasting, and dredging operation on the navigable waters of Boston Inner Harbor... navigable waters during the drilling, blasting and dredging operations in support of the U.S. Army Corps of... vicinity of the drilling, dredging and blasting operations being conducted. For the safety concerns noted...

  6. Environmental Assessment for Boston Harbor Maintenance Dredging, Boston, Massachusetts.

    Science.gov (United States)

    1981-12-01

    into the harbor, but the sources have never been documented. It is not unusual for the swimming beaches to be closed following a storm of moderate...sand lance involve either swimming in schools or burrowing In suitable substrate. Impacts to their natural schooling movements are iikely to be short...Edison (December 1976 - May 1977) Appendix B Boston Inner Harbor Species List Scientific Name Comm~on Nam~e CNIDARIA (Hycdroids, Anemones, Jellyfish

  7. Boston bombings: response to disaster.

    Science.gov (United States)

    Hemingway, Maureen; Ferguson, Joanne

    2014-02-01

    Disasters disrupt everyone's lives, and they can disrupt the flow and function of an OR as well as affect personnel on a professional and personal level even though perioperative departments and their personnel are used to caring for trauma patients and coping with surprises. The Boston Marathon bombing was a new experience for personnel at Massachusetts General Hospital, Boston. This article discusses the incidents surrounding the bombing and how personnel at this hospital met the challenge of caring for patients and the changes we made after the experience to be better prepared in the event a response to a similar incident is needed. Copyright © 2014 AORN, Inc. Published by Elsevier Inc. All rights reserved.

  8. Potenciais benefícios do sistema de rastreabilidade animal dos EUA para o setor de carnes americano

    Directory of Open Access Journals (Sweden)

    Moisés de Andrade Resende Filho

    2008-12-01

    Full Text Available Este artigo investigou os potenciais ganhos do setor de carnes americano advindos da implantação do Sistema Nacional de Identificação Animal (NAIS, dos EUA. Foram analisados os potenciais efeitos do NAIS sobre a percepção de risco dos consumidores americanos em relação aos perigos decorrentes do consumo das carnes bovina, suína e de aves e seus derivados. Sistemas de equações de demanda foram estimados, incorporando-se como "proxies" da percepção de risco do consumidor, séries de índices de segurança do alimento, separadamente construídas para cada tipo de carne. Tais séries foram concebidas, somando-se o número de referências nos principais jornais americanos a problemas de segurança da carne. Foi utilizado o melhor modelo estimado, escolhido com base em uma série de testes de especificação, para se construir três cenários, simulando-se os casos em que o NAIS não está implementado; que está implementado apenas para o gado bovino; e que está implementado para suínos e bovinos. Foram utilizadas as diferenças entre as receitas estimadas para cada cenário e para cada tipo de carne, como uma medida do potencial ganho advindo da implementação do NAIS. Foi concluído que os setores da carne bovina e suína poderiam arcar com os custos do NAIS. Esse resultado, contudo, depende de o quanto desses potenciais ganhos chegarão efetivamente aos produtores agrícolas.This article investigates the potential gains to the U.S. meat sector with the implantation of the U.S. National Animal Identification System (NAIS. The focus is on the effect that the NAIS could have on consumers' risk perception about eating meat. System of demand equations are estimated using time series of food safety indexes variables used as proxies for consumers' reactions to news on meat safety issues. The series of food safety indexes are built on the basis of the number of food safety news reported in top U.S. newspapers. Using the preferred model

  9. Boston keratoprosthesis in epithelial downgrowth

    Science.gov (United States)

    Sa-ngiampornpanit, Tarinee; Thiagalingam, Sureka; Dohlman, Claes H.

    2009-01-01

    Introduction To report a case of histologically proven epithelial downgrowth after multiple failed penetrating keratoplasties and glaucoma filtering surgeries that was successfully treated with Boston keratoprosthesis implantation. Materials and Methods A 61-year-old monocular patient had severe congenital ocular syphilis with secondary glaucoma. He had undergone many intraocular surgeries with a history of epithelial downgrowth, and he presented with a failed graft after 7 penetrating keratoplasties. Implantation of a corneal graft with an aphakic type of Boston keratoprosthesis was performed, combined with anterior vitrectomy. The main outcome measures were visual acuity, ocular inflammation and media clarity. Results Media clarity was restored and revealed severe retinal scarring and a pale optic nerve. Best corrected visual acuity of 20/400 was maintained without any further surgical intervention during 6 years follow up. No retroprosthesis membrane or epithelial growth behind the keratoprosthesis was observed. Discussion This is, to our knowledge, the first case of long-term successful treatment of epithelial downgrowth with a Boston keratoprosthesis. This approach might be considered a suitable treatment of epithelial downgrowth. PMID:29276452

  10. A crise ucraniana e as Estratégias Nacionais de Defesa dos EUA e da Europa: a volta do hard power?

    Directory of Open Access Journals (Sweden)

    João Fábio Bertonha

    2014-11-01

    Full Text Available O presente artigo discute a recente crise na Ucrânia e as implicações em termos estratégicos do choque entre a OTAN, a União Europeia e a Rússia. Mais especificadamente, o texto procura compreender o uso do hard power por parte da Federação russa e como isso pode levar a uma reavaliação da postura idealista da União Europeia no tocante a suas relações internacionais e de sua Estratégia de Defesa. Do mesmo modo, o texto questiona a possibilidade e/ou necessidade de alterações na Estratégia de Defesa nos EUA frente à crise no leste europeu. This article discusses the recent crisis in Ukraine and the strategic implications of the clash between NATO, the European Union and Russia. More specifically, the text seeks to understand the use of the hard power by the Russian Federation during the crisis and how this use can lead to a reassessment of European idealistic approach of international relations and military matters. At the same time, the article discusses the possibility and/or necessity of changes in American military strategies to deal with future problems in Eastern Europe.

  11. 77 FR 19573 - Safety Zone; Wedding Fireworks Display, Boston Inner Harbor, Boston, MA

    Science.gov (United States)

    2012-04-02

    ... in the vicinity of Anthony's Pier 4, Boston, MA for a wedding fireworks display. This temporary... ``Document Type'' drop down menu select ``Proposed Rule'' and insert ``USCG-2012-0130'' in the ``Keyword... Boston Inner Harbor in the vicinity of Anthony's Pier 4, Boston, MA. The Captain of the Port (COTP...

  12. Trends in indices for extremes in daily air temperature over Utah, USA Tendências de indices de extremos para temperatura do ar diária sobre Utah, EUA

    Directory of Open Access Journals (Sweden)

    Carlos Antonio Costa dos Santos

    2011-03-01

    Full Text Available The main objective of this study was to obtain analysis of the trends in eleven annual extreme indices of temperature for Utah, United State of America (USA. The analyses have been obtained for 28 meteorological stations, in general, for the period of 1930 to 2006, characterizing a long-term period and with high quality data. The software used to process the data was the RClimdex 1.0. The analysis has identified that the temperature increased in Utah during the last century, evidencing the importance of the ongoing research on climate change in many parts of the world.O principal objetivo desse estudo foi analisar as tendências de onze indices de extremos climáticos baseados em dados diários de temperatura do ar, obtidos a partir de 28 estações meteorológicas localizadas em Utah, Estados Unidos da America (EUA. Em geral, os dados foram coletados entre 1930 e 2006, apresentando coerente resolução temporal e espacial. O software utilizado no processamento dos dados foi o RClimdex 1.0. As análises dos índices extremos mostraram que a temperatura aumentou em Utah durante o último século, evidenciando a importância das pesquisas sobre mudanças climáticas em diferentes partes do mundo.

  13. Idiopatiske skolioser behandlet med Boston-korset

    DEFF Research Database (Denmark)

    Andersen, M O; Andersen, G R; Kruuse, A M

    1993-01-01

    It is well known that Boston bracing may stop progression in many patients with minor curves. One hundred and thirty-eight patients were treated with the Boston brace for idiopathic scoliosis. Age was 14.1 +/- 1.6 years at the time of bracing, and the length of time spent in the brace was 2.6 +/- 1...

  14. Report From Boston: The Struggle for Desegregation

    Science.gov (United States)

    Chancy, Joette; Franklin, Brenda

    1975-01-01

    A report on the school integration controversy in Boston by one of the coordinators of the National Student Coalition Against Racism (NASCAR), an organization that has been building national support for school desegregation in Boston, and by a former staff member of NASCAR who has toured the U. S. to explain the issues involved in the Boston…

  15. Boston type I keratoprosthesis: Review.

    Science.gov (United States)

    Magalhães, Fernanda Pedreira; Sousa, Luciene Barbosa de; Oliveira, Lauro Augusto de

    2012-01-01

    Regardless of significant progress in the field of corneal transplantation to treat corneal opacification, some cases of corneal blindness still present a poor prognosis for conventional penetrating keratoplasty. In patients with repeated graft failure and/or with severe ocular surface disease, the Boston type I keratoprosthesis (type I BKPro) has become a viable option. Modifications in its design and postoperative management have improved the long-term outcomes of visual acuity, retention, and postoperative infection rates. These advances made the type I BKPro be considered a safe alternative for visual rehabilitation in many patients with corneal pathologies. However, postoperative handle of chronic comorbidities, such as glaucoma, is still critical for preserving the visual gains achieved with BKPro.

  16. Boston type I keratoprosthesis: Review

    Directory of Open Access Journals (Sweden)

    Fernanda Pedreira Magalhães

    2012-06-01

    Full Text Available Regardless of significant progress in the field of corneal transplantation to treat corneal opacification, some cases of corneal blindness still present a poor prognosis for conventional penetrating keratoplasty. In patients with repeated graft failure and/or with severe ocular surface disease, the Boston type I keratoprosthesis (type I BKPro has become a viable option. Modifications in its design and postoperative management have improved the long-term outcomes of visual acuity, retention, and postoperative infection rates. These advances made the type I BKPro be considered a safe alternative for visual rehabilitation in many patients with corneal pathologies. However, postoperative handle of chronic comorbidities, such as glaucoma, is still critical for preserving the visual gains achieved with BKPro.

  17. Evitando o debate público: os intelectuais universitários nos EUA do pós-guerra Far from the public debate: the university intellectuals in Post War USA

    Directory of Open Access Journals (Sweden)

    João Feres Júnior

    2007-05-01

    Full Text Available Neste artigo, examinaremos um pouco da história das relações entre academia e serviço público nos EUA no período que sucedeu a Segunda Guerra Mundial. Ao invés de ressaltar as qualidades individuais dos principais intelectuais desse período, tentamos identificar os fatores institucionais e políticos que contribuíram para a consolidação de um trânsito entre o discurso especializado da academia e ações políticas que, às vezes, passaram ao largo do debate público. Entre outras coisas, pretendemos mostrar que, no caso em questão, a lógica exterior do discurso acadêmico não era a mesma da lógica de reprodução da academia como instituição. Palavras-chave: Intelectuais. Ciências Sociais. Guerra Fria. EUA. Debate público. In this paper we examine the history of the relations between the academy and the public service in the USA, soon after the Second World War. Instead of emphazing the individual qualities of the proeminent intellectuals of the period, we try to identify the institutional and political factors that contributed for a dialogue between the especialized academic discourse and the political actions that, sometimes, were far from the public debate. Among other things, we intend to show that the exterior logic of the academic discourse was not the same logic of reproduction of the academy as an institution. Keywords: Intellectuals. Social Sciences. Cold War. USA. Public debate.

  18. Política de segurança dos EUA para a América Latina após o final da Guerra Fria

    Directory of Open Access Journals (Sweden)

    Monica Herz

    2002-12-01

    Full Text Available O ARTIGO analisa a política de segurança dos EUA para a América Latina a partir do final da Guerra Fria. São consideradas as principais transformações deste aspecto da política externa norte americana para a região. A tendência à incorporação de novos temas à agenda de segurança, em particular a manutenção de regimes democrático, o narcotráfego e as migrações é investigada, assim como a presença militar norte americana na região. A relevância que a região andina adquire nos anos 90 e a disposição das três primeiras administrações do pós Guerra Fria de incentivar mecanismos multilaterais para a área da segurança também são avaliados.THE ARTICLE analyses North American security policy regarding Latin America since the end of the Cold War. The main transformations of this aspect of the US's foreign policy toward the region are considered. The tendency to incorporate new themes to the security agenda, such as the preservation of democracy, drug traffic and production and illegal migration is investigated. The US military presence in the region is also looked into. The importance that the Andean sub region acquired during the 1990s and the desire of the three first post Cold War administrations to stimulate the creation and reconstruction of multilateral mechanisms in the security sphere are evaluated.

  19. Preparedness in America's prime danger zone and at the Boston Marathon bombing site.

    Science.gov (United States)

    Cole, Leonard A; Scott, Sandra R; Feravolo, Michael; Lamba, Sangeeta

    2014-01-01

    The area between Newark and Elizabeth, NJ, contains major transportation hubs, chemical plants, and a dense population. This makes it "the most dangerous two miles in America," according to counterterrorism officials at the Federal Bureau of Investigation. This study compares medical response capabilities for terror and disaster in Newark, New Jersey's largest city, with those in Boston in view of that city's favorable response to the Marathon bombings in April 2013. Boston's numerous world-class medical facilities offer advantages unavailable in Newark and most other metropolitan locations. Thus, preparedness in Newark, despite its prime-danger designation, can also be instructive for many communities with similar medical resources. Three categories of response capabilities are assessed: hospital resources, relevant personnel, and symposia/exercises. Data were derived from hospital Web sites, the New Jersey and Massachusetts Hospital Asso-ciations, communications with emergency response personnel, and interviews with spokespersons for hospitals. Boston's population (618,000) is more than twice Newark's (278,000), and the number of hospitals and hospital beds in each city reflects that proportion. However, Boston's seven general adult hospitals include five level 1 trauma centers (which can provide comprehensive trauma care), whereas Newark's four hospitals include only one such center.Beds per 1,000 people are similarly disparate in those trauma centers: five in Boston, 1.5 in Newark. Emergency Medical Services (EMS) personnel based in Boston and Newark are comparable in numbers, though full-time hospital physicians/dentists and nurses are not. The number of doctors at Boston's five level 1 centers is more than triple that at all four of Newark's hospitals (5,284 vs 1,494). The disparity between nurses at the two sites is even greater (6,784 vs 1,566).There is greater equivalency between the two cities both in content and frequency of symposia/exercises. Hospitals

  20. Development of an adapted version of the Boston Naming Test for Portuguese speakers Desenvolvimento de uma versão adaptada do Boston Naming Test para a língua portuguesa

    Directory of Open Access Journals (Sweden)

    Eliane C. Miotto

    2010-09-01

    Full Text Available OBJECTIVE: To present the development of an adapted version of the Boston Naming Test for Portuguese speakers, and to investigate the effects of age, education and gender on both the original and the adapted Boston Naming Test in respect of Brazilian Portuguese speakers. METHOD: Eighty items, including the 60 original ones and 20 adapted items were administered to 739 healthy Brazilian subjects aged between 6 and 77 years who received 0 to 17 years of education. RESULTS: The coefficients of the General Linear Model estimation suggested that both age and education were statistically significant to predict total scores. In addition, score variances, justified by such predictors, were 41.20% in the original Boston Naming Test against 25.84% in the adapted Boston Naming Test. These results suggest that the scores from the original BNT are more dependent on age and education than those from the adapted Boston Naming Test. CONCLUSION: These findings demonstrated the suitability of the adapted Boston Naming Test version for the Brazilian population and described provisional norms for the original and adapted Boston Naming Test for Portuguese speakers.OBJETIVO: Apresentar o desenvolvimento de uma versão adaptada do Boston Naming Test para a língua portuguesa e investigar os efeitos da idade, escolaridade e gênero nas versões original e adaptada do Boston Naming Test. MÉTODO: 80 itens foram administrados incluindo os 60 originais e 20 itens adaptados em 739 brasileiros saudáveis com idades entre 6 e 77 anos e escolaridade entre 0 e 17 anos. RESULTADOS: Os coeficientes de estimação do Modelo Linear Geral sugeriram que a idade e escolaridade eram preditores significativos do resultado total. Além disto, as variâncias dos resultados explicadas por estes preditores no Boston Naming Test original era de 41,20%, enquanto que no adaptado era de 25,84%. Estes achados sugerem que os resultados do Boston Naming Test original são mais dependentes de

  1. Infectious keratitis in patients undergoing Boston Type 1 keratoprosthesis (Boston KPro procedure: case series

    Directory of Open Access Journals (Sweden)

    Heloisa Moraes do Nascimento

    2011-04-01

    Full Text Available Description of two cases of infectious keratitis in patients after Boston Type 1 keratoprosthesis (Boston KPro implantation. The first case refers to a patient that had the device indicated due to limbal deficiency secondary to severe dry eye who presented a fungal infection by Aerobasidium pullulans that was successfully treated with amphotericin B eye drops. The second case reports a patient with Boston KPro implantation due to previous corneal transplant rejection showing bacterial keratitis in the fourth postoperative month. The etiologic agent was identified asStreptococcus sp and topical treatment with vancomycin was effective. The importance of postoperative surveillance in Boston KPro eyes is discussed.

  2. Brancas de almas negras? : beleza, racialização e cosmética na imprensa negra pós-emancipação (EUA, 1890-1930)

    OpenAIRE

    Giovana Xavier da Conceição Côrtes

    2012-01-01

    Resumo: Esta tese investiga as representações femininas presentes em propagandas de produtos de clareamento de pele (bleachings) e crescedores capilares (hair growers) da indústria cosmética, veiculadas pela imprensa afro-americana em Boston, Chicago e Nova York, cidades que, entre os anos 1890 e 1930, passaram por uma série de transformações sociais por conta do fenômeno historicamente conhecido como Grande Migração Negra. Ao considerar o processo de urbanização vivenciado pela população de ...

  3. AVALIAÇÃO DE PESSEGUEIROS E NECTARINEIRAS INTRODUZIDOS NO BRASIL, PROCEDENTES DA FLÓRIDA, EUA

    Directory of Open Access Journals (Sweden)

    W. BARBOSA

    1997-09-01

    Full Text Available Avaliou-se o comportamento vegetativo e reprodutivo de vinte e dois pessegueiros e treze nectarineiras introduzidos no Brasil, provenientes da Universidade da Flórida, Gainesville, EUA. O material foi avaliado por três anos na Estação Experimental de Jundiaí, do IAC(23o08'S; 46o55'W, anotando-se as características: número de nós de gemas por metro de ramo e de gemas vegetativas e floríferas por nó; porcentagem de frutificação efetiva; ciclo de maturação dos frutos; coloração da película e polpa; textura e acidez da polpa e época de colheita. Verificou-se que os cinco cultivares e seleções que apresentaram grande quantidade de gemas foram: Sungem; Fla 3-4N; Fla 6-4; Fla 84-16N e Okinawa, com 51,1; 50,8; 45,8; 45,2 e 44,2 nós de gemas por metro de ramo respectivamente. Considerando o nº de gemas por nó, observou-se que Desertgold (2,36, Sunwright (2,32, Rubro-sol (2,24, Sunlite (2,21, Newbelle (2,16 e Sundowner (2,13 foram os cultivares com maior potencial de desenvolvimento de folhas e flores. As melhores frutificações ocorreram em `Okinawa'(66,3%, `TropicBeauty' (51,1%, `Flordastar'(50,0%, Fla 84-4(48,5% e `Flordaprince'(41,5%. Os pêssegos `Flordadawn', Fla 84-5, Fla 84-4, `Flordastar' e Oro A constituiram-se nos mais precoces, com ciclos de 75 a 85 dias da florada à maturação dos frutos e colheitas desde meados de setembro até início de outubro. Verificou-se que as novas seleções como Fla 84-5, Fla 84-16N, Fla 84-4 e Fla 84-13N possuem características agronômicas favoráveis à persicultura paulista e aos cruzamentos com as seleções do IAC. São dois pêssegos e duas nectarinas de polpa amarela, produtivos, precoces, menos ácidos, com oBrix 12 a 15 e pH 3,8 a 4,0. Os cultivares e seleções mais tolerantes à ferrugem foram: Fla 9-11N, Sundowner, Sunlite, Fla 87-3 e Fla 84-16 e ao chumbinho: Sunwright, Fla 82-23N, Fla 9-11N, Flordadawn e Fla 1-8, sendo 70% nectarinas.Twenty-two peaches and thirteen

  4. Eyelid Mass in Boston Keratoprosthesis Type 2.

    Science.gov (United States)

    Choi, Catherine J; Stagner, Anna M; Jakobiec, Frederick A; Chodosh, James; Yoon, Michael K

    Boston keratoprosthesis type 2 is used to treat severe corneal blindness secondary to cicatricial or autoimmune ocular surface disease. This case report describes an atypical eyelid mass in a 41-year-old woman with Stevens-Johnson syndrome who underwent placement of Boston keratoprosthesis type 2 in the left eye. The postoperative course was complicated by methicillin-sensitive Staphylococcus aureus keratitis and endophthalmitis requiring replacement of the keratoprosthesis. Three months thereafter, the patient presented with a progressively enlarging upper eyelid mass adjacent to the keratoprosthesis optic causing distortion of the eyelid. Excisional biopsy revealed an elongated cystic mass abutting the superior aspect of the optic. Pathologic examination was consistent with a conjunctival cyst with lipogranulomatous reaction. Removal of eyelid margins and conjunctiva, and placement of a full-thickness blepharotomy are standard steps in placement of Boston keratoprosthesis type 2, which can lead to conjunctival cysts and lipogranulomas that present as eyelid masses.

  5. A chegada da peste: cem anos da viagem de Freud aos EUA (1909-2009

    Directory of Open Access Journals (Sweden)

    Myriam Chinalli

    2010-10-01

    Manchester, em Massachussets. Mostra, também, a importância da viagem para a difusão da ainda desconhecida psicanálise, para o estabelecimento de relações, futuros encontros, trocas e alianças. Evidencia que, de certa forma, as Cinco lições de psicanálise – conferências que passaram desde então a ser traduzidas em diversos idiomas – garantiram que os fundamentos da nova ciência fossem amplamente divulgados. Fala também das inquietações freudianas a respeito de como a psicanálise estaria sendo absorvida pelos norte-americanos e dos desdobramentos nos Estados Unidos decorrentes da viagem.

  6. Ceratoprótese de Boston Boston Keratoprosthesis

    Directory of Open Access Journals (Sweden)

    Sérgio Kwitko

    2012-12-01

    Full Text Available Uma breve revisão de resultados e complicações da ceratoprótese (KPro de Dohlman-Doane tipo 1. A KProDohlman-Doane é atualmente uma boa opção em casos graves de cegueira corneana, para os quais o transplante penetrante de córnea não apresenta bom prognóstico. As evoluções no design da KPro e as melhorias no procedimento cirúrgico, aliados a obtenção de condições favoráveis da superfície ocular pré-operatórias, garantem bons resultados da KPro em doenças não autoimunes. As principais complicações da KPro são membrana inflamatória retroprotética de fibrina, glaucoma, necrose corneana, vitreíte e infecção (ceratite e endoftalmite. Acompanhamento constante com exames pós-operatórios periódicos é necessário para monitorar e prevenir complicações sérias.A short review of type 1 Dohlman-DoaneKeratoprosthesis (KPro addresses results and complications. Dohlman-DoaneKPro is today a good option for cases of corneal blindness with poor prognosis for traditional penetrating keratoplasty. KPro design and surgical improvements along with proper preoperative ocular surface condition allows good results in non-immune diseases. Main complications of this KPro areinflammatory retroprosthetic membrane, glaucoma, corneal melting,vitreitis, and infection (keratitis and endophthalmitis. Comprehensive long-term postoperative follow-up examinationsare needed to monitor for and prevent serious complications.

  7. 2009 National Renewable Energy Labratory/Boston Redevelopment Authority Topographic LiDAR: Boston, Massachusetts

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Alliance for Sustainable Energy, LLC contracted with Sanborn to provide LiDAR mapping services for the Boston area. Utilizing multi-return systems, Light...

  8. 2009 National Renewable Energy Laboratory/Boston Redevelopment Authority Topographic LiDAR: Boston, Massachusetts

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Alliance for Sustainable Energy, LLC contracted with Sanborn to provide LiDAR mapping services for the Boston area. Utilizing multi-return systems, Light...

  9. Constructing an Interactive Tutorial: "Boston Massacre."

    Science.gov (United States)

    Schick, James B. M.

    1992-01-01

    Discusses "Boston Massacre," an interactive tutorial game for learning about the Revolutionary War incident. Describes the development of the game and its academic uses. Includes instructions, a sample student response sheet, short answer and multiple choice examinations, and a listing of teacher resources. Reminds history teachers that…

  10. Art and Historical Truth: The Boston Massacre.

    Science.gov (United States)

    Agresto, John

    1979-01-01

    Discusses the inaccuracy of Revere's "Boston Massacre" print as a description of historical fact. Notes, however, that the print is still a description of truth, a correct understanding of the meaning and portent of the occurrence in a way that historical accuracy (rather than art) might well have distorted. (JMF)

  11. Boston Water & Sewer Commission (BWSC) | Stormwater ...

    Science.gov (United States)

    2017-04-10

    The Boston Water and Sewer Commission (BWSC) was issued National Pollutant Discharge Elimination System (NPDES) Permit MAS010001, which became effective on October 29, 1999, authorizing stormwater and allowable non-stormwater discharges from its municipal separate storm sewer system (MS4).

  12. Writing Boston: Graffiti Bombing as Community Publishing

    Science.gov (United States)

    Lesh, Charles

    2017-01-01

    Working as an ethnographer with graffiti writers in Boston, the author has collected a range of materials, and experiences. Graffiti writing is a patently spatial practice, and existing scholarship across disciplines has emphasized this situated relationship between graffiti and the production of, and resistance to, contemporary, neoliberal…

  13. Uma análise do financiamento da educação no estado da Califórnia, EUA A review of educational financing in the state of California, USA

    Directory of Open Access Journals (Sweden)

    José Marcelino de Rezende Pinto

    2005-12-01

    Full Text Available Este trabalho é fruto de um estágio de pesquisa no Estado da Califórnia (EUA e tem como objetivo analisar as principais características do financiamento da educação desse estado. A Califórnia possui 33 milhões de habitantes e cerca de seis milhões de alunos em seu sistema de educação básica que vai da pré-escola (kindergarten, em que as crianças entram com cinco anos de idade, até a 12ª série. O principal desafio enfrentado pelo estado, motivado principalmente por decisões judiciais, tem sido o de assegurar um patamar mínimo de recursos por aluno e o de evitar uma grande discrepância nos gastos por aluno entre distritos pobres e ricos. O que se constata é que o segundo objetivo tem sido parcialmente obtido mas basicamente mediante um nivelamento por baixo, de tal forma que o estado se coloca, hoje, em 40º lugar no ranking dos gastos por aluno no país.This paper is the product of a research program in the State of California (USA, which aims it to analyze the main characteristics of the educational financing in that State. California has 33 million inhabitants and some 6 million primary students attending school from kindergarten - 5-years olds - through 12th grade. The major challenge faced by the State - mainly due to court decisions - is ensuring a minimum level of financial resources per student and avoiding discrepancy in spending per student between poor and rich districts. This second objective has been partially attained by lowering the level of State spending, so that California is, nowadays, the 40th in the American ranking of spending per student.

  14. Outcomes of the Boston Keratoprosthesis in Jordan

    Science.gov (United States)

    Shihadeh, Wisam A.; Mohidat, Hasan M.

    2012-01-01

    Purpose: To report the indications, outcomes, and complications of the Boston type I keratoprosthesis (KPro) from the first Jordanian study on the subject. Materials and Methods: A retrospective chart review was conducted on 20 eyes of 19 consecutive patients who had Boston type I KPro implantation at King Abdullah University Hospital. Surgeries were performed by the same surgeon (WS) from November 2007 to March 2010. Data collected included age, sex, primary indication, number of previous grafts, preoperative comorbidities, visual acuity before and after surgery, and complications. Results: The mean age of the participants was 51.7±19.9 years (range: 10–80 years). The mean follow-up was 18.1±9.5 months (range: 3–6 months). The most common primary corneal pathology was vascularized corneal opacity (40%). Best corrected visual acuity (BCVA) improved significantly in 85% of eyes; 65% had a BCVA of 20/200 or better and 25% had a BCVA of 20/50 or better. The most frequent complication was retroprosthesis membrane (RPM) formation, which occurred in 45% of eyes. Two eyes (10%) had implant extrusion and required further surgery. Conclusion: Boston Kpro offers a reasonably safe and effective solution for patients with corneal blindness in whom the prognosis for natural corneal grafting is poor. PMID:22346122

  15. Os perigos dos Negros Brancos: cultura mulata, classe e beleza eugênica no pós-emancipação (EUA, 1900-1920

    Directory of Open Access Journals (Sweden)

    Giovana Xavier da Conceição Nascimento

    2015-06-01

    Full Text Available Por meio da articulação entre história social da cultura e do trabalho, o artigo discute o processo de fortalecimento da "cultura mulata" promovido por intelectuais afro-americanos das classes alta e média no período pós-emancipação. Ao analisar o "problema da liberdade" com base nos referenciais de beleza construídos por esses "novos negros", trago à cena textos e fotografias coletados das revistas The Half Century Magazine, de Boston, e The Crisis: a record of the darker races, de Nova York. Os magazines e outros títulos evidenciam que, entre 1900 e 1930, o sistema de segregação intrarracial baseado na tonalidade da pele ("colorismo" trouxe como consequência a "pigmentocracia". Ou seja, o privilégio da pele clara (light skin em relação à escura (dark skin no tocante às oportunidades de mobilidade social.

  16. Boston keratoprosthesis type I in the elderly.

    Science.gov (United States)

    Homayounfar, Gelareh; Grassi, Christina M; Al-Moujahed, Ahmad; Colby, Kathryn A; Dohlman, Claes H; Chodosh, James

    2017-04-01

    To determine the outcomes of Boston type I keratoprosthesis implanted in elderly patients. A retrospective case series was performed on patients at least 75 years old who received the Boston type I keratoprosthesis between 1 January 2007 and 31 December 2012. Preoperative diagnosis, interval visual acuity, keratoprosthesis retention and postoperative complications were recorded for each patient. Forty-four Boston type I keratoprostheses were implanted in 44 eyes of 43 patients. The most common indication for surgery was corneal graft failure (n=23; 52.3%) followed by corneal scar (n=8; 18.2%) and limbal stem cell dysfunction (n=8; 18.2%). All patients had preoperative visual acuity of ≤20/200. Thirty-six of 44 (82%) patients achieved visual acuity of 20/200 or better postoperatively, and 20 of those (55.6%) maintained 20/200 or better for 1 year after surgery. The median length of follow-up was 825 days (range: 27-2193 days), and at the last follow-up visit, 20 of 44 (45.5%) had 20/200 or better vision. The median best-corrected visual acuity (logMAR) improved from 2.6 preoperatively to 1.0 at 1 year postoperative (pkeratoprosthesis is an effective modality in corneal blindness in elderly patients. Failure to restore or maintain ambulatory vision was typically due to non-corneal comorbidities, often unrelated to the keratoprosthesis. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  17. 33 CFR 165.120 - Safety Zone: Chelsea River, Boston Inner Harbor, Boston, MA.

    Science.gov (United States)

    2010-07-01

    ... is a safety zone: The waters of the Chelsea River, Boston Inner Harbor, for 100 yards upstream and... the Jenny Dock (approximate position latitude 42°23′05.2″ N., longitude 71°01′35.8″ W.)—or the Mobile...

  18. Boston Architectural College Urban Sustainability Initiative

    Energy Technology Data Exchange (ETDEWEB)

    Byers, Arthur C.

    2013-07-31

    The Boston Architectural College's Urban Sustainability initiative is a demonstration project as defined by the National Energy Technology Laboratory. BAC's proposed project with the U.S. Department of Energy - NETL, is a large part of that overall initiative. The BAC's Urban Sustainability Initiative is a multi-part project with several important goals and objectives that will have a significant impact on the surrounding neighborhood including: energy conservation, reduction of storm water runoff, generation of power through alternative energy sources, elimination/reduction of BAC carbon footprint, and to create a vehicle for ongoing public outreach and education. Education and outreach opportunities will serve to add to the already comprehensive Sustainability Design courses offered at BAC relative to energy savings, performance and conservation in building design. At the finish of these essential capital projects there will be technical materials created for the education of the design, sustainability, engineering, community development and historic preservation communities, to inform a new generation of environmentally-minded designers and practitioners, the city of Boston and the general public. The purpose of the initiative, through our green renovations program, is to develop our green alley projects and energy saving renovations to the BAC physical plant, to serve as a working model for energy efficient design in enclosed 19th century and 20th century urban sites and as an educational laboratory for teaching ecological and sustainable technologies to students and the public while creating jobs. The scope of our project as it relates to the BAC and the U.S. Department of Energy- NETL combined efforts includes: Task I of the project is Phase II (Green Alley). Task I encompasses various renovation activities that will demonstrate the effectiveness of permeable paving and ground water recharge systems. It will aid in the reduction of storm water

  19. Deus está do nosso lado: excepcionalismo e religião nos EUA With God on our side: religion and american exceptionalism

    Directory of Open Access Journals (Sweden)

    Carlos da Fonseca

    2007-06-01

    Full Text Available O objetivo deste artigo é analisar as origens e a evolução de alguns dos mitos religiosos "fundacionais" dos EUA, e seu papel no surgimento de uma noção de excepcionalismo, principal determinante da identidade norte-americana tal como expressa na política externa desse país.The goal of this paper is to analyze the origins and the evolution of America’s religious foundational myths, and their role in the inception of the idea of "exceptionalism", the main determinant of US political identity as expressed in foreign policy.

  20. Winsor, Dewey, and Putnam: The Boston Experience. Occasional Papers.

    Science.gov (United States)

    Davis, Donald G., Jr.; Carpenter, Kenneth E.; Wiegand, Wayne A.; Aikin, Jane

    This volume contains three papers about early library leaders with Boston (Massachusetts) connections. Donald G. Davis, Jr. provides an introduction to the papers. "Justin Winsor, Librarian and Scholar" (Kenneth E. Carpenter) discusses the life of Justin Winsor, who was director of the Boston Public Library (1868-76), president of the…

  1. Fear of Crime among Elderly Jews in Boston and London.

    Science.gov (United States)

    Ginsberg, Yona

    1985-01-01

    Examines the impact of fear of crime on the daily behavior of elderly Jews in racially mixed, deteriorating neighborhoods in Boston and London. Results showed the Boston elderly retreated behind locked doors, while the London elderly continued their daily routine. (JAC)

  2. Notas sobre pentecostalismo y poder entre inmigrantes latinoamericanos en la ciudad de Newark (New Jersey, E.U.A.

    Directory of Open Access Journals (Sweden)

    Otto Maduro

    2007-06-01

    Full Text Available La literatura reciente y creciente sobre el fenómeno pentecostal -al igual que una investigación en la que participo sobre iglesias latinas en Newark, la mayor ciudad del Estado de Nueva Jersey en E.U.A. - sugiere, entre otras cosas, que muchos migrantes latinoamericanos (y otros grupos e individuos negativamente privilegiados hallan en el pentecostalismo una suerte de "caja de herramientas" socio-religiosas extremadamente útiles para enfrentar y superar creativamente las dificultades inherentes a la migración, especialmente en el caso de personas aisladas migrando a lugares donde se hallan en relativa desventaja económica, cultural, lingüística, legal y/o educacional. En este corto ensayo se intenta simplemente enumerar y describir algunas de las dinámicas desencadenadas en ese encuentro entre migrantes latinoamericanos e iglesias pentecostales, que parecen repetirse de maneras análogas en distintos sitios, y que reiteradamente parecen contribuir a aumentar las posibilidades de supervivencia creativa de migrantes latinoamericanos en situación de dificultad.The recent, growing literature on Pentecostalism - as well as an ongoing research on Hispanic churches in which I am involved in Newark, the largest city in New Jersey - suggest, among other things, that many Latin American immigrants (and other groups equally negatively privileged seem to find in Pentecostalism a set of extremely useful socio-religious "toolkit" to creatively face and overcome the hurdles inherent in the migrant experience, especially in the case of isolated individuals and small groups moving into milieus where they find themselves in a particularly challenging or disadvantageous situation, be it economic, cultural, linguistic, legal and/or educational. In this brief essay, I will attempt to contextualize and describe some of the dynamics unchained through such encounters between Latin American immigrants and Pentecostal churches, especially as they occur in

  3. Boston type 1 keratoprosthesis for failed keratoplasty.

    Science.gov (United States)

    Hager, Jonathan L; Phillips, David L; Goins, Kenneth M; Kitzmann, Anna S; Greiner, Mark A; Cohen, Alex W; Welder, Jeffrey D; Wagoner, Michael D

    2016-02-01

    The purpose of this study was to evaluate the outcomes of the Boston type 1 keratoprosthesis (Kpro-1) in eyes with failed keratoplasty. A retrospective review was performed of every patient treated with a Kpro-1 at a tertiary eye care center between January 1, 2008 and July 1, 2013. Eyes with a failed keratoplasty originally performed for corneal edema, trauma, or keratoconus were included in the statistical analysis. The main outcome measures were visual outcome, prosthesis retention, and postoperative complications. Twenty-four eyes met the inclusion criteria, including 13 eyes with corneal edema, 8 eyes with trauma, and 3 eyes with keratoconus. After a mean follow-up period of 28.9 months (range 7-63 months), the median best corrected visual acuity (BCVA) was 20/125. The BCVA was ≥ 20/40 in 4 (16.7 %) eyes, ≥ 20/70 in 9 (37.5 %) eyes, and ≥ 20/200 in 14 (58.3 %) eyes. Overall, the postoperative BCVA improved in 17 (70.9 %) eyes, was unchanged in 3 (12.5 %) eyes, and was worse in 4 (16.7 %) eyes. The initial Kpro-1 was retained in 22 (91.7 %) eyes, and was successfully repeated in the other 2 eyes. One or more serious prosthesis- or sight-threatening complications occurred in 8 (33.3 %) eyes. These included 1 case of wound dehiscence leading to prosthesis extrusion, 1 case of fungal keratitis leading to prosthesis extrusion, 4 cases of endophthalmitis, and 5 retinal detachments. The Boston Kpro-1 is associated with an excellent prognosis for prosthesis retention and satisfactory visual improvement in eyes with previous failed keratoplasty.

  4. Boston, the Booth Brothers, and the Parker House

    Directory of Open Access Journals (Sweden)

    Susan Wilson

    2015-05-01

    Full Text Available April 14, 2015 was the 150th anniversary of the assassination of President Abraham Lincoln. This is the story of how that fateful day was linked to Boston, the Booth Brothers, and the Parker House.

  5. Case Study Evaluation of the Boston Area Carpooling Program

    Science.gov (United States)

    1976-05-01

    The report evaluates a carpooling program in operation in the Boston, Massachusetts area from August, 1973 through August, 1974. The program, entitled the WBZ/ALA Commuter Computer Campaign, was the first program in the nation to promote and organize...

  6. Results with the Boston Type I keratoprosthesis after Acanthamoeba keratitis.

    Science.gov (United States)

    Santos, Albert; Silva, Luzia Diegues; de Sousa, Luciene Barbosa; de Freitas, Denise; de Oliveira, Lauro Augusto

    2017-06-01

    To report the outcomes of implantation of the Boston Type I keratoprosthesis in three patients with Acanthamoeba keratitis (AK), a severe infection that can lead to significant visual loss. Case series reporting three patients with difficult cases of AK that needed multiple corneal transplantations and glaucoma surgeries. All patients were implanted with the Boston Type I keratoprosthesis device. The main outcomes measure were the visual function and anatomical retention after implantation of the Boston Type I keratoprosthesis. All patients retained the device over the long-term and had good visual function. In one patient a retroprosthetic membrane developed and in another patient an epithelial lip developed over the anterior surface of the keratoprosthesis. The visual acuities range from 20/25 to 20/80 in the implanted eyes. The Boston Type I keratoprosthesis resulted in good anatomic and functional results after multiple graft failures after AK.

  7. Boston Harbor and approaches samples (WILLETT72 shapefile

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Boston Harbor (and its approaches) is a glacially carved, tidally dominated estuary in western Massachusetts Bay. Characterized by low river discharge and...

  8. 2: April 30-May 1, 2012, Boston, USA

    National Research Council Canada - National Science Library

    Ho, Mitchell; Royston, Ivor; Beck, Alain

    2012-01-01

    The 2nd Annual Antibodies for Cancer Therapy symposium, organized again by Cambridge Healthtech Institute as part of the Protein Engineering Summit, was held in Boston, USA from April 30 th to May 1 st , 2012...

  9. Túnel bajo el puerto de Boston

    Directory of Open Access Journals (Sweden)

    Editorial, Equipo

    1963-05-01

    Full Text Available The new tunnel under Boston harbour has been constructed because of the insufficient capacity of a similar, earlier, tunnel to cope with the ever increasing road traffic. This tunnel is 1,550 ms long, and 9.50 ms in external diameter. There are two traffic lanes, each 3.20 ms wide. Inside it is faced with ceramic tiles, has fluorescent lighting, and ventilation is maintained by means of two ducts, one at each entrance, where the necessary compressor and other equipment has been situated. The most interesting feature of this important project is the excavation method adopted for its construction: the tunnel crosses a clay layer, which at certain places is sufficiently fluid to allow a pneumatic shield to be forced through it leaving hardly any debris behind. It will be readily appreciated that this procedure shows an obvious advantage over ordinary methods, in which it is necessary to cut out, and transport to the exterior all the excavated material. The metal sheathing was by the Commercial Shearing and Stamping Co., Youngstown, Ohio.Este nuevo túnel, bajo el puerto de Boston, es una consecuencia de la necesidad imperiosa que se hacía sentir dada la insuficiente capacidad del otro túnel similar antiguo y el aumento continuo del tráfico urbano y por carretera. Tiene 1.550 m de longitud, 9,50 m de diámetro exterior y una calzada con dos bandas de circulación de 3,20 m de anchura cada una. Está revestido ccn baldosa cerámica, iluminado con luz fluorescente, y el aire viciado se ventila y renueva por medio de dos torres de ventilación—una en cada portal—, en las que se han instalado el equipo mecánico adecuado de ventilación y compresores. La parte más interesante de esta importante obra estriba en los procedimientos empleados para llevar a cabo la excavación, pues atraviesa un banco de arcilla que, en ciertos tramos, es suficientemente fluida para permitir dejarse empujar y ceder paso a un escudo neumático que avanza sin apenas

  10. Results with the Boston Type I keratoprosthesis after Acanthamoeba keratitis

    OpenAIRE

    Santos, Albert; Silva, Luzia Diegues; Sousa,Luciene Barbosa de; Freitas, Denise de; Oliveira,Lauro Augusto de

    2017-01-01

    Purpose: To report the outcomes of implantation of the Boston Type I keratoprosthesis in three patients with Acanthamoeba keratitis (AK), a severe infection that can lead to significant visual loss. Observations: Case series reporting three patients with difficult cases of AK that needed multiple corneal transplantations and glaucoma surgeries. All patients were implanted with the Boston Type I keratoprosthesis device. The main outcomes measure were the visual function and anatomical reten...

  11. Vision Restoration with a Collagen Crosslinked Boston Keratoprosthesis Unit

    Science.gov (United States)

    2016-09-01

    AWARD NUMBER: W81XWH-15-2-0044 TITLE: Vision Restoration with a Collagen Crosslinked Boston Keratoprosthesis Unit PRINCIPAL INVESTIGATOR: Joseph B...TITLE AND SUBTITLE 5a. CONTRACT NUMBER Vision Restoration with a Collagen Cross-linked Boston Keratoprosthesis Unit 5b. GRANT NUMBER W81XWH-15-2-0044...the incidence or potentially eliminate corneal melts by strengthening the keratoprosthesis carrier tissue by collagen -crosslinking the cornea graft

  12. Terrorist bombings: foreign bodies from the Boston Marathon bombing.

    Science.gov (United States)

    Brunner, John; Singh, Ajay K; Rocha, Tatiana; Havens, Joaquim; Goralnick, Eric; Sodickson, Aaron

    2015-02-01

    On April 15, 2013, 2 improvised explosive devices detonated at the 117th Boston Marathon, killing 3 people and injuring 264 others. In this article, the foreign bodies and injuries that presented at 2 of the responding level 1 trauma hospitals in Boston-Brigham and Women׳s Hospital and Massachusetts General Hospital--are reviewed with a broader discussion of blast injuries and imaging strategies. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. The Boston marathon bombings: the early plastic surgery experience of one Boston hospital.

    Science.gov (United States)

    Kim, Peter S; Malin, Edward; Kirkham, John C; Helliwell, Lydia A; Ibrahim, Ahmed M S; Tobias, Adam M; Upton, Joseph; Lee, Bernard T; Lin, Samuel J

    2013-11-01

    On April 15, 2013, at approximately 2:49 p.m. EDT, two improvised explosive devices detonated near the finish line of the 117th Boston Marathon. Patients were transported from the scene to several trauma centers, including the authors' institution. Plastic surgical assessment of patients began in the Emergency Department and then rapidly expanded as the scope of the incident became clear. Daily interdisciplinary meetings involving the acute care surgery, orthopedic surgery, plastic surgery, and nursing services were convened in order to coordinate operating room schedules and treatment plans. An interdisciplinary weekly clinic continued until all patient goals had been reached. Twenty-four patients were treated at Beth Israel Deaconess Medical Center within the first 24 hours of the Boston Marathon bombing. Seven were triaged directly to the operating room from the Emergency Department. The Division of Plastic Surgery was directly involved with the care of 11 patients, all of whom were treated surgically within 24 hours of the bombing. Patients were aged 23 to 50 years old. All 11 patients sustained lower extremity injuries with gross contamination. Four patients also sustained significant upper extremity trauma. Injuries included extremity amputations and fractures, soft-tissue loss, impaction of nails and other debris, burns, ocular injury, and ruptured tympanic membranes. Twenty-four patients received acute care at Beth Israel Deaconess Medical Center following the Boston Marathon bombing. Institution of dedicated interdisciplinary daily rounds, protected operating room block time, and joint follow-up clinic allowed for efficient early diagnosis and treatment of patients' injuries.

  14. Shore, Gary. Drácula: A história nunca contada. EUA, 2014, 92 min.

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Calixto Moreira Monteiro

    2015-12-01

    Full Text Available A resenha versa acerca dos aspectos relevantes ao contexto social e linguístico da adaptação fílmica realizada por Gary Shore, em 2014, da obra Drácula, publicada por Bram Stoker em 1897. Utilizando-se dos pressupostos da fidelidade literária, da Disneyization e do papel do signo peirceano, a resenha busca expor os elementos que contornam o processo da adaptação cinematográfica e como se completam no público-alvo.

  15. Boston Keratoprosthesis Type 1 in Chemical Burns.

    Science.gov (United States)

    Salvador-Culla, Borja; Kolovou, Paraskevi E; Arzeno, Linnette; Martínez, Santiago; López, Miguel A

    2016-06-01

    To describe and further analyze the long-term results in visual acuity (VA), anatomical retention, and rate of complications from patients who underwent Boston keratoprosthesis (B-Kpro) type 1 after ocular chemical burns in the Dominican Republic. A retrospective review of 42 eyes (22 OD:20 OS) of 36 patients who underwent B-Kpro type 1 implantation after severe ocular burn at Hospital Elías Santana in Santo Domingo, Dominican Republic, between April 2006 and October 2014, were included. Demographics, VA, anatomical retention, and the rates of postoperative complications and concurrent surgeries were evaluated. The excellent anatomical retention rates and visual outcomes presented in this study support the remarkable capability of B-Kpro type 1 to restore functional VA in eyes with severe chemical injuries. However, strict control of the postoperative complications is necessary for long-term success. In conclusion, the use of a B-Kpro type 1 after severe chemical burn is a viable option in patients otherwise condemned to the high risk of failure associated with conventional corneal grafts.

  16. Titanium Coating of the Boston Keratoprosthesis.

    Science.gov (United States)

    Salvador-Culla, Borja; Jeong, Kyung Jae; Kolovou, Paraskevi Evi; Chiang, Homer H; Chodosh, James; Dohlman, Claes H; Kohane, Daniel S

    2016-04-01

    We tested the feasibility of using titanium to enhance adhesion of the Boston Keratoprosthesis (B-KPro), ultimately to decrease the risk of implant-associated complications. Cylindrical rods were made of poly(methyl methacrylate) (PMMA), PMMA coated with titanium dioxide (TiO2) over a layer of polydopamine (PMMATiO2), smooth (Ti) and sandblasted (TiSB) titanium, and titanium treated with oxygen plasma (Tiox and TiSBox). Topography and surface chemistry were analyzed by scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). Adhesion force between rods and porcine corneas was measured ex vivo. Titanium sleeves, smooth and sandblasted, were inserted around the stem of the B-KPro and implanted in rabbits. Tissue adhesion to the stem was assessed and compared to an unmodified B-Kpro after 1 month. X-ray photoelectron spectroscopy demonstrated successful deposition of TiO2 on polydopamine-coated PMMA. Oxygen plasma treatment did not change the XPS spectra of titanium rods (Ti and TiSB), although it increased their hydrophilicity. The materials did not show cell toxicity. After 14 days of incubation, PMMATiO2, smooth titanium treated with oxygen plasma (Tiox), and sandblasted titanium rods (TiSB, TiSBox) showed significantly higher adhesion forces than PMMA ex vivo. In vivo, the use of a TiSB sleeve around the stem of the B-KPro induced a significant increase in tissue adhesion compared to a Ti sleeve or bare PMMA. Sandblasted titanium sleeves greatly enhanced adherence of the B-KPro to the rabbit cornea. This approach may improve adhesion with the donor cornea in humans as well. This approach may improve adhesion with donor corneas in humans.

  17. Excellence through Change: SLA in Boston.

    Science.gov (United States)

    Mark, Linda

    1986-01-01

    Summary of the 1986 Special Libraries Association Conference covers a general session on managing organizational change and programs on entrepreneurship in corporate libraries, staff training, access to government information, ethics and new technology, networking inside corporations, and creating a positive image through marketing. (EM)

  18. Satellite Monitoring of Boston Harbor Water Quality: Initial Investigations

    Science.gov (United States)

    Sheldon, P.; Chen, R. F.; Schaaf, C.; Pahlevan, N.; Lee, Z.

    2016-02-01

    The transformation of Boston Harbor from the "dirtiest in America" to a National Park Area is one of the most remarkable estuarine recoveries in the world. A long-term water quality dataset from 1991 to present exists in Boston Harbor due to a $3. 8 billion lawsuit requiring the harbor clean-up. This project uses discrete water sampling and underway transects with a towed vehicle coordinated with Landsat 7 and Landsat 8 to create surface maps of chlorophyll a (Chl a), dissolved organic matter (CDOM and DOC), total suspended solids (TSS), diffuse attenuation coefficient (Kd_490), and photic depth in Boston Harbor. In addition, 3 buoys have been designed, constructed, and deployed in Boston Harbor that measure Chl a and CDOM fluorescence, optical backscatter, salinity, temperature, and meteorological parameters. We are initially using summer and fall of 2015 to develop atmospheric corrections for conditions in Boston Harbor and develop algorithms for Landsat 8 data to estimate in water photic depth, TSS, Chl a, Kd_490, and CDOM. We will report on initial buoy and cruise data and show 2015 Landsat-derived distributions of water quality parameters. It is our hope that once algorithms for present Landsat imagery can be developed, historical maps of water quality can be constructed using in water data back to 1991.

  19. Boston type 1 keratoprosthesis: the university of california davis experience.

    Science.gov (United States)

    Bradley, Jay C; Hernandez, Enrique Graue; Schwab, Ivan R; Mannis, Mark J

    2009-04-01

    To compare the University of California Davis experience using the Boston keratoprosthesis with the Boston Keratoprosthesis Study Group's initial report. Retrospective chart review. We analyzed 30 eyes of 28 patients who previously underwent Boston type 1 keratoprosthesis surgery at our institution between 2004 and 2008. Preoperative, intraoperative, and postoperative parameters were collected and analyzed. Visual acuity and keratoprosthesis stability. Preoperative diagnoses were failed graft (26 eyes, 87%), chemical injury (3 eyes, 10%), and Stevens-Johnson syndrome (1 eye, 3%). Twenty eyes (66%) had preoperative glaucoma. Preoperative best-corrected visual acuity ranged from 20/150 to light perception and was or=20/200 in 77% of eyes. Among eyes at least 1 year after the operation (16 eyes), vision was >or=20/200 in 75% of eyes and >or=20/40 in 25% of eyes. At an average follow-up of 19 months, retention of the initial keratoprosthesis was 83.3%. The Boston type 1 keratoprosthesis is a viable option after multiple keratoplasty failures or in conditions with a poor prognosis for primary keratoplasty. Patients with autoimmune disease are at higher risk for complications. The University of California Davis experience seems equivalent to the initial report of the Boston Keratoprosthesis Study Group. With longer follow-up, additional surgical procedures may be required but good anatomic and functional outcomes can be maintained.

  20. The Boston Marathon versus the World Marathon Majors.

    Directory of Open Access Journals (Sweden)

    Philip B Maffetone

    Full Text Available To compare finish times across WMM races for Boston, London, Berlin, Chicago and New York Marathons.Race times of the top 10 male and 10 female finishers were analyzed from 2005 to 2014 using the high-performance mixed linear model procedure in the Statistical Analysis System. Venue-to-venue comparisons, as well as comparisons between Boston and other WMM races, with and without factors of temperature, humidity and altitude change were examined.Performance from 2005 to 2014 in the WMM races was found to improve at a rate of ~1% each 7 years. Despite its higher variability, comparison between Boston's estimated mean finishing time and all other venues revealed moderate positive differences, indicating the Boston event to be typically slower than other venues.Across the 10-year study period, performance times improved ~1% each 7 years for both genders for the WMM, with the Boston Marathon being slower on average than other WMM venues. Weather rather than course metrics appeared to impact performance times most.

  1. Pigmented deposits on a Boston keratoprosthesis from topical ibopamine.

    Science.gov (United States)

    Kanoff, Justin M; Colby, Kathryn

    2010-09-01

    To report a case of pigmented deposits on a type I Boston keratoprosthesis (KPro) associated with the use of topical ibopamine as a treatment for hypotony. Case report and literature review. The dopamine-like agent ibopamine caused black deposits on the bandage lens and on the front plate of the Boston KPro that resulted in reduced visual acuity. Change to a daily disposable contact lens and regular cleaning of the KPro front plate with diluted baby shampoo eliminated this problem. This is the first report of this complication with topical ibopamine use and should be considered when ibopamine is used chronically for hypotony.

  2. 75 FR 21367 - Advanced Electronics, Inc.; Boston, MA; Notice of Negative Determination on Remand

    Science.gov (United States)

    2010-04-23

    ... Employment and Training Administration Advanced Electronics, Inc.; Boston, MA; Notice of Negative... Department of Labor (Department) for further investigation Former Employees of Advanced Electronics, Inc. v... Adjustment Assistance (ATAA) applicable to workers and former workers of Advanced Electronics, Inc., Boston...

  3. Media's role in broadcasting acute stress following the Boston Marathon bombings

    National Research Council Canada - National Science Library

    E. Alison Holman; Dana Rose Garfin; Roxane Cohen Silver

    2014-01-01

    .... We conducted an Internet-based survey following the Boston Marathon bombings between April 29 and May 13, 2013, with representative samples of residents from Boston (n = 846), New York City (n = 941...

  4. La regulación de las nanotecnologías: una mirada desde las diferencias EUA-UE | A regulação das nanotecnologias: um olhar desde as diferenças EUA-UE

    Directory of Open Access Journals (Sweden)

    Guillermo Foladori

    2016-05-01

    nanotecnologias está em discussão em nível mundial. A discussão gira em torno a duas questões principais: os potenciais riscos para a saúde e o meio ambiente, e a normalização e homogeneização de critérios para a comercialização. Este artigo analisa as posições assumidas pelos Estados Unidos e a União Europeia, potencias que comandam a discussão sobre regulação em nível internacional, e a partir da qual muitos outros países tomarão posição. As fontes utilizadas para identificar os principais princípios filosófico-jurídicos que se aplicam à regulação das nanotecnologias foram os corpos legais que regulam os químicos nos Estados Unidos (TSCA-EPA e na Europa (REACH. Aplicamos a análise de discurso sobre os documentos, analisando-os em seu contexto histórico (análise genealógico e elucidando as funções de exclusão realizadas. Complementamos a informação com documentos específicos sobre regulação das nanotecnologias, revisão de literatura e análise de alguns casos específicos de aplicação de normas. Identificamos cinco conceitos filosófico-jurídicos nos quais há evidentes dicotomias entre as posições dos Estados Unidos e da União Europeia. Eles envolvem temas como precaução, confidencialidade, transparência de informação, perigo e avaliação custo-benefício. As conclusões mostram, de um lado, que embora existam importantes diferenças discursivas entre ambos blocos, a prática e as coações do contexto exercem pressão sobre estes. De outro lado, evidenciam que existem fisuras e contradições internas dentro de cada bloco, dotando de incerteza o desenvolvimento futuro. Finalmente, o trabalho oferece um “pacote de conceitos” utilizados por cada bloco, de utilidade analítica para elaborar agendas nacionais próprias.

  5. Comparación y predicción de las cuotas mundiales de publicación de los EUA, EU-27 y China usando la nueva interfaz Web of science versus Scopus

    NARCIS (Netherlands)

    Leydesdorff, L.

    2012-01-01

    La nueva interfaz de la Web of science (de Thomson Reuters) permite ahora recuperar conjuntos de más de 100.000 documentos en una sola búsqueda. Esto hace posible comparar las tendencias de publicación de los EUA, UE-27 y China -y evidentemente también de los países más pequeños-, cosa que ya se

  6. Boston College Case Shows Weakness of Researchers' Confidentiality Pledges

    Science.gov (United States)

    Schmidt, Peter

    2012-01-01

    The author reports on a legal battle over oral-history records housed at Boston College that casts light on how little legal weight pledges of confidentiality to research subjects actually have. As a federal court weighs whether to let the federal government seize, and hand over to British authorities, the college's records of confidential…

  7. VITREORETINAL COMPLICATIONS IN EYES WITH BOSTON KERATOPROSTHESIS TYPE I.

    Science.gov (United States)

    Rishi, Pukhraj; Rishi, Ekta; Koundanya, Vikram V; Mathur, Gaurav; Iyer, Geetha; Srinivasan, Bhaskar

    2016-03-01

    To describe the spectrum of vitreoretinal complications in eyes with Boston keratoprosthesis type I and evaluate the treatment outcomes. This was a retrospective interventional case series of 23 of 45 eyes that underwent Boston keratoprosthesis from April 2003 to December 2013 and developed vitreoretinal complications. Types of vitreoretinal complications, surgical techniques, and anatomical and visual outcomes were analyzed. Vitreoretinal complications in eyes with Boston keratoprosthesis included retroprosthetic membranes (n = 11), retinal detachment (n = 6), endophthalmitis (n = 4), epiretinal membrane (n = 4), vitreous hemorrhage (n = 2), and choroidal detachment (n = 1). Twenty of 23 eyes (87%) underwent surgical intervention. Retinal reattachment was achieved in 5 eyes (83%) with significant visual improvement in 3 (50%). Mean preoperative visual acuity improved from 1.84 ± 0.89 logMAR to 1.5 ± 0.87 logMAR (P = 0.01) at the last follow-up. Mean 1.4 surgical procedures were performed per eye. Mean follow-up was 28 months (median: 28 months, range: 5-57 months). Retroprosthetic membrane and retinal detachment are most common vitreoretinal complications in eyes with Boston keratoprosthesis. Vitreoretinal complications can be managed by appropriate intervention in such eyes with encouraging anatomical and functional results.

  8. Clinical research progress of Boston type I keratoprosthesis

    Directory of Open Access Journals (Sweden)

    Jia-Qi Chen

    2015-01-01

    Full Text Available Boston Type I keratoprosthesis is currently widely used. In this article, the indication, number of cases, best-corrected visual acuity(BCVA, retention, and complications in all the international published case reports will be sum up; then the main post-operative complications and their respective treatments one by one, which include retrospective membrane, glaucoma, infection will be introduced.

  9. Boston Naming Test Discontinuation Rule: "Rigorous" versus "Lenient" Interpretations.

    Science.gov (United States)

    Ferman, Tanis J.; Ivnik, Robert J.; Lucas, John A.

    1998-01-01

    Two interpretations of the Boston Naming Test (BNT) (E. Kaplan, H. Goodglass, and S. Weintraub, 1983) discontinuation rule of six consecutive failures were found in BNT use with 655 normal older adults and 140 people with Alzheimer's disease. Differences between lenient and rigorous interpretations of responses could have impact on…

  10. Charter, Private, and Public Schools Work Together in Boston

    Science.gov (United States)

    Lam, Diana

    2014-01-01

    A public, Catholic, and charter school in Boston all work together to share their strengths and learn from each other in an effort to deliver the best education for all of their students. The arrangement is called the School Performance Partnership, and it is a grantee of the Bill and Melinda Gates Foundation.

  11. Early weaning might reduce the psychological strain of Boston bracing

    DEFF Research Database (Denmark)

    Andersen, Mikkel Ø; Andersen, Gert Rahbek; Thomsen, Karsten

    2002-01-01

    From 1983 to 1990 a total of 136 patients with adolescent idiopathic scoliosis were treated with the Boston brace. With the aim of examining the social and psychological impact of the brace treatment all patients received a questionnaire at an average of 3.5 years after termination of the treatment...

  12. The Boston keratoprosthesis type I in mucous membrane pemphigoid.

    Science.gov (United States)

    Palioura, Sotiria; Kim, Bryan; Dohlman, Claes H; Chodosh, James

    2013-07-01

    To evaluate the use of the Boston keratoprosthesis type I implantation in patients with mucous membrane pemphigoid (MMP). Retrospective review of 8 eyes of 8 patients with severe ocular surface disease and corneal blindness as a result of MMP who underwent Boston keratoprosthesis type I implantation at the Massachusetts Eye and Ear Infirmary from January 1, 2000, through December 31, 2009. The main outcome measures were best-corrected visual acuity, keratoprosthesis retention, and postoperative complications. The mean age of patients was 71.3 years (range, 55-94 years), and the mean duration of their disease preoperatively was 6.1 years (range, 1.7-11.4 years). Visual acuity after the surgery improved to 20/200 or better in 6 eyes (75%) and to 20/40 or better in 3 eyes (37.5%). Only 1 of 6 eyes (16.7%) was able to maintain visual acuity of 20/200 or better over a mean follow-up period of 3.2 years. Five of the 8 Boston keratoprosthesis type I devices (62.5%) extruded or had to be replaced during a mean follow-up time of 1.7 ± 1.7 years. Loss of vision to worse than 20/200 during the follow-up period occurred because of keratoprosthesis type I extrusion, end-stage glaucoma, and retinal or choroidal detachment. The clinical outcomes of Boston keratoprosthesis type I implantation in MMP are guarded and, as judged from the literature, less favorable than those with the Boston keratoprosthesis type II for the same disease.

  13. O primeiro a utilizar anestesia em cirurgia não foi um dentista. Foi o m édico Crawford Williamson Long El primero en utilizar la anestesia en cirugía no fue un dentista, fue el médico Crawford Williamson Long The first to use surgical anesthesia was not a dentist, but the physician Crawford Williamson Long

    Directory of Open Access Journals (Sweden)

    Almiro dos Reis Júnior

    2006-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A história da descoberta da anestesia continua incompletamente esclarecida em vários de seus aspectos. Mas é fácil definir que Crawford Williamson Long foi o primeiro a utilizar o éter sulfúrico para operar vários pacientes, sem dor, e realizar analgesias obstétricas. A história é uma ponte que liga o passado ao presente e deve ser estudada e entendida desde os seus primeiros pilares. Assim, justifica-se lembrar ou dar a conhecer quem foi Long, um nome certamente pouco conhecido entre nós, e qual a participação dele na descoberta da anestesia. CONTEÚDO: São discorridos porque e como Crawford Williamson Long foi levado a se tornar o primeiro médico a operar sem dor, quatro anos e meio antes de Morton, e o papel que desempenhou numa das maiores descobertas da Medicina. A biografia de Long é narrada, ressaltando-se o seu caráter, a competência, a dedicação, a modéstia, o desprendimento e um certo desapego com relação à conquista da glória. Descrevem-se as circunstâncias que o levaram a não divulgar de imediato sua descoberta. É analisado o envolvimento de Long na discussão pela primazia da descoberta da anestesia e relatado o seu falecimento. As numerosas homenagens recebidas por Long nos EUA e em outros países são citadas. CONCLUSÕES: W. T. G. Morton costuma ser considerado como o autor da descoberta da anestesia geral, sobretudo por ter sido o primeiro a fazer demonstração pública bem-sucedida, em importante hospital de Boston (EUA. Contudo, provou-se que Long foi o primeiro a utilizar a anestesia cirúrgica e é reconhecido em várias regiões de seu país como o pai da anestesia cirúrgica e "o seu descobridor". É necessário, ainda, reverter o fato de ser Long pouco conhecido entre nós e inseri-lo no lugar a que tem direito na história da anestesia geral.JUSTIFICATIVA Y OBJETIVOS: La historia del descubrimiento de la anestesia continúa sin ser completamente aclarada en varios

  14. The Path Forward: School Autonomy and Its Implications for the Future of Boston's Public Schools. Understanding Boston

    Science.gov (United States)

    French, Dan; Hawley Miles, Karen; Nathan, Linda

    2014-01-01

    Boston Public Schools is at a crossroads. Nearly one-third of the system's schools operate under one of several "autonomy" structures, where school leaders have increased flexibility regarding staffing and other resources, and choice data indicate parents are far more likely to prefer these schools over so-called "traditional"…

  15. Custo de transação e mensuração na escolha da estrutura de governança entre supermercados e produtores agrícolas convencionais e orgânicos no Brasil e nos EUA

    Directory of Open Access Journals (Sweden)

    Christiano França da Cunha

    2015-03-01

    Full Text Available Pressupõe-se que o ambiente institucional tem um papel relevante em determinar a governança, já que este pode implicar diferentes custos de transação para os agentes econômicos. Tendo como base a Nova Economia Institucional (NEI, o objetivo deste artigo foi entender como os custos de transação podem influenciar um dos principais elementos de escolha da estrutura de governança, a complexidade das relações contratuais, e como esta influência pode variar nos distintos ambientes institucionais. Para isso, estudou-se a relação contratual entre supermercados e fornecedores de produtos (frutas, verduras e legumes - FLV orgânicos e convencionais em dois diferentes ambientes institucionais (Brasil e EUA. Testaram-se as hipóteses propostas neste artigo por meio de 128 entrevistas, as quais foram analisadas por meio dos modelos de equações estruturais, sendo que um mesmo modelo teórico foi estimado para dois grupos (os dois países para comparação de seus coeficientes. Os resultados encontrados mostraram que a influência dos custos de transação na complexidade da relação contratual, afetando assim a escolha entre as estruturas de governança, foi diferente a depender do ambiente institucional considerado. Conclui-se ao final deste trabalho que há evidências empíricas, demonstradas pelos resultados dos modelos de equações estruturais aqui utilizados, de que o ambiente institucional pode alterar as influências sobre a complexidade das relações contratuais e assim na escolha da estrutura de governança a ser utilizada.

  16. Tourniquet use at the Boston Marathon bombing: Lost in translation.

    Science.gov (United States)

    King, David Richard; Larentzakis, Andreas; Ramly, Elie P

    2015-03-01

    The Boston Marathon bombing was the first major, modern US terrorist event with multiple, severe lower extremity injuries. First responders, including trained professionals and civilian bystanders, rushed to aid the injured. The purpose of this review was to determine how severely bleeding extremity injuries were treated in the prehospital setting in the aftermath of the Boston Marathon bombing. A database was created and populated by all the Boston Level I trauma centers following the Boston Marathon bombing. Data regarding specific injuries, extremities affected, demographics, prehospital interventions (including tourniquet types), and outcomes were extracted. Of 243 injured, 152 patients presented to the emergency department within 24 hours. Of these 152 patients, there were 66 (63.6% female) experiencing at least one extremity injury, with age ranging from younger than 15 years to 71 years, and with a median Injury Severity Score (ISS) of 10 (range, 1-38). Of the 66 injured patients, 4 had upper limbs affected, 56 had injuries on the lower limbs only, and 6 had combined upper and lower limbs affected. The extremity Abbreviated Injury Scale (AIS) scores had a median of 3 (range, 1-4). There were 17 lower extremity traumatic amputations in 15 patients. In addition, there were 10 patients with 12 lower extremities experiencing major vascular injuries. Of 66 injured patients, 29 patients had recognized extremity exsanguination at the scene. In total, 27 tourniquets were applied: 16 of 17 traumatic amputations, 5 of 12 lower extremities with major vascular injuries, and 6 additional limbs with major soft tissue injury. All tourniquets were improvised, and no commercial, purpose-designed tourniquets were identified. Among all 243 patients, mortality was 0%. After the Boston Marathon bombings, extremity exsanguination at the point of injury was either left untreated or treated with an improvised tourniquet in the prehospital environment. An effective, prehospital

  17. Boston Society's 11th Annual Applied Pharmaceutical Analysis conference.

    Science.gov (United States)

    Lee, Violet; Liu, Ang; Groeber, Elizabeth; Moghaddam, Mehran; Schiller, James; Tweed, Joseph A; Walker, Gregory S

    2016-02-01

    Boston Society's 11th Annual Applied Pharmaceutical Analysis conference, Hyatt Regency Hotel, Cambridge, MA, USA, 14-16 September 2015 The Boston Society's 11th Annual Applied Pharmaceutical Analysis (APA) conference took place at the Hyatt Regency hotel in Cambridge, MA, on 14-16 September 2015. The 3-day conference affords pharmaceutical professionals, academic researchers and industry regulators the opportunity to collectively participate in meaningful and relevant discussions impacting the areas of pharmaceutical drug development. The APA conference was organized in three workshops encompassing the disciplines of regulated bioanalysis, discovery bioanalysis (encompassing new and emerging technologies) and biotransformation. The conference included a short course titled 'Bioanalytical considerations for the clinical development of antibody-drug conjugates (ADCs)', an engaging poster session, several panel and round table discussions and over 50 diverse talks from leading industry and academic scientists.

  18. Future Nuisance Flooding at Boston Caused by Astronomical Tides Alone

    Science.gov (United States)

    Ray, Richard D.; Foster, Grant

    2016-01-01

    Sea level rise necessarily triggers more occurrences of minor, or nuisance, flooding events along coastlines, a fact well documented in recent studies. At some locations nuisance flooding can be brought about merely by high spring tides, independent of storms, winds, or other atmospheric conditions. Analysis of observed water levels at Boston indicates that tidal flooding began to occur there in 2011 and will become more frequent in subsequent years. A compilation of all predicted nuisance-flooding events, induced by astronomical tides alone, is presented through year 2050. The accuracy of the tide prediction is improved when several unusual properties of Gulf of Maine tides, including secular changes, are properly accounted for. Future mean sea-level rise at Boston cannot be predicted with comparable confidence, so two very different climate scenarios are adopted; both predict a large increase in the frequency and the magnitude of tidal flooding events.

  19. Innovative approaches to glaucoma management of Boston keratoprosthesis type 1.

    Science.gov (United States)

    Vajaranant, Thasarat S; Liu, Jessica; Wilensky, Jacob; Cortina, M Soledad; Aref, Ahmad A

    2016-09-01

    Glaucoma remains a prevalent disorder and visual limiting factor after Boston keratoprosthesis type 1 implantation. Patients with glaucoma have worse initial and late visual acuity outcomes after otherwise successful keratoprosthesis implantation. Management of glaucoma in the setting of a keratoprosthesis is challenging because of relatively rapid progression and an inability to accurately measure intraocular pressure (IOP). In addition, there are no standard guidelines for glaucoma surveillance and monitoring after keratoprosthesis surgery. This report provides a review of the current literature and offers innovative strategies that will overcome the challenges in managing glaucoma in the setting of a Boston keratoprosthesis type 1 implant. The topics that will be discussed in this section include alternative methods for IOP measurement, rationales and surgical techniques for a pars plana tube placement for glaucoma drainage device, effective medical and laser treatment, the risk for IOP elevations after YAG laser, and practical guides to glaucoma surveillance and monitoring.

  20. Innovative approaches to glaucoma management of Boston keratoprosthesis type 1

    Science.gov (United States)

    Vajaranant, Thasarat S.; Liu, Jessica; Wilensky, Jacob; Cortina, M. Soledad; Aref, Ahmad A.

    2016-01-01

    Glaucoma remains a prevalent disorder and visual limiting factor after Boston keratoprosthesis type 1 implantation. Patients with glaucoma have worse initial and late visual acuity outcomes after otherwise successful keratoprosthesis implantation. Management of glaucoma in the setting of a keratoprosthesis is challenging because of relatively rapid progression and an inability to accurately measure intraocular pressure (IOP). In addition, there are no standard guidelines for glaucoma surveillance and monitoring after keratoprosthesis surgery. This report provides a review of the current literature and offers innovative strategies that will overcome the challenges in managing glaucoma in the setting of a Boston keratoprosthesis type 1 implant. The topics that will be discussed in this section include alternative methods for IOP measurement, rationales and surgical techniques for a pars plana tube placement for glaucoma drainage device, effective medical and laser treatment, the risk for IOP elevations after YAG laser, and practical guides to glaucoma surveillance and monitoring. PMID:28529825

  1. Retention of the Boston keratoprosthesis type 1: multicenter study results.

    Science.gov (United States)

    Ciolino, Joseph B; Belin, Michael W; Todani, Amit; Al-Arfaj, Khalid; Rudnisky, Christopher J

    2013-06-01

    To report the retention rate of the Boston keratoprosthesis type 1 and to identify risk factors for keratoprosthesis loss. Cohort study. A total of 300 eyes of 300 patients who underwent implantation of the Boston keratoprosthesis type I device between January 2003 and July 2008 by 19 surgeons at 18 medical centers. Forms reporting preoperative, intraoperative, and postoperative parameters were prospectively collected and subsequently analyzed at a central data collection site. Keratoprosthesis retention. A total cumulative number of 422 life-years of device implantation are included in this analysis. The average duration of follow-up was 17.1 ± 14.8 months, with a range of 1 week to >6.1 years. Ninety-three percent of the 300 Boston keratoprosthesis implants were retained at their last follow-up, corresponding to a retention time of 396 patient-years or 1.42 years/keratoprosthesis. The probability of retention after 1 year and 2 years was 94% and 89%, respectively. During the study period, 21 (7%) eyes failed to retain the device; the reasons for keratoprosthesis loss include sterile keratolysis (9), fungal infections (8), dense retroprosthetic membranes (3), and bacterial endophthalmitis (1). Multivariate analysis demonstrated 3 independent risk factors for keratoprosthesis loss: autoimmune cause (hazard ratio [HR], 11.94; 95% confidence interval [CI], 3.31-43.11), ocular surface exposure requiring a concomitant tarsorrhaphy (HR, 3.43; 95% CI, 1.05-11.22), and number of prior failed penetrating keratoplasties (HR, 1.64; 95% CI, 1.18-2.28). The Boston keratoprosthesis type 1 seems to be a viable option for eyes that are not candidates for penetrating keratoplasty (PK). Ocular surface disease due to an autoimmune cause demonstrated the lowest retention rate. The author(s) have no proprietary or commercial interest in any materials discussed in this article. Copyright © 2013 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  2. Contact lens surveillance cultures in Boston type 1 keratoprosthesis patients.

    Science.gov (United States)

    Rai, Ruju; Shorter, Ellen; Cortina, Maria S; McMahon, Timothy; de la Cruz, Jose

    2013-03-01

    To describe surveillance cultures of bandage contact lenses (BCL) in patients with a history of Boston type 1 keratoprosthesis (KPro) surgery. An institutional review board-approved retrospective review of patients with a history of Boston type 1 KPro surgery and BCL cultures between July 2008 and June 2010. Data on demographics, preoperative diagnosis, topical corticosteroid and antibiotic use, duration of BCL wear, clinical diagnosis of microbial keratitis or endophthalmitis, and culture results were recorded. There were 14 patients (15 eyes) who underwent Boston type 1 KPro between July 2008 and June 2010 with BCL culture data. Ten eyes showed positive growth and one eye developed an infection. Thirty-four cultures were performed and 12 were positive. The most common organism cultured was coagulase-negative staphylococcus (CoNS). Positive cultures, colonization by non-CoNS pathogens, and infection occurred more frequently in patients with an ocular history of autoimmune disease or chemical burn. The growth of 15 or more CoNS colonies occurred only in patients not on vancomycin. An antibiotic was added to the regimen in response to positive cultures for three patients. Contact lens surveillance cultures may provide valuable information on the characteristics of microbial colonization, particularly in highlighting inflammatory disease and disuse of vancomycin as possible risk factors. Bandage contact lenses cultures also have the potential to be useful adjuncts in the clinical management of antibiotic therapy.

  3. Health-hazard evaluation report HETA 85-441-1765, New Boston Coke Corporation, New Boston, Ohio

    Energy Technology Data Exchange (ETDEWEB)

    O' Malley, M.A.

    1986-12-01

    In response to a request from the Industrial Commission of Ohio, worker complaints of skin disease at the New Boston Coke Corporation, New Boston, Ohio were investigated. The request was based on seven reports of dermatitis thought to be associated with steam exposure during coke quenching. Quench water had a pH of 8.85 and contained phenol, ammonia, calcium-oxide, and suspended particulates (82% organic compounds); no irritant threshold levels were found for these compounds. Skin tests in rabbits showed a minimal irritant capacity for quench water. Medical records did not reveal the origin of dermatitis. Active skin lesions were characterized as nummular eczema or atopic dermatitis, which were not thought to be of occupational origin. The author concludes that coke-quenching steam does not pose a skin hazard, but certain work activities may aggravate existing skin conditions. Recommendations include elimination of abrasive cleansing agents, use of skin moisturizers after washing, and prompt medical evaluation of skin complaints.

  4. International results with the Boston type I keratoprosthesis.

    Science.gov (United States)

    Aldave, Anthony J; Sangwan, Virender S; Basu, Sayan; Basak, Samar K; Hovakimyan, Anna; Gevorgyan, Ofelya; Kharashi, Soliman Al; Jindan, Mohanna Al; Tandon, Radhika; Mascarenhas, Jeena; Malyugin, Boris; Padilla, Ma Dominga B; Maskati, Quresh; Agarwala, Nisheeta; Hutauruk, Johan; Sharma, Manoj; Yu, Fei

    2012-08-01

    To determine the indications and outcomes of Boston type 1 keratoprosthesis (Massachusetts Eye and Ear Infirmary, Boston, MA) surgery performed outside of North America and to compare them with those obtained in the United States by the surgeon who trained the international surgeons. Retrospective review of consecutive clinical case series. One hundred ninety-four patients (223 keratoprosthesis procedures performed in 205 eyes) who received Boston type 1 keratoprosthesis at 11 ophthalmology centers in Armenia, India, Indonesia, Nepal, Philippines, Russia, and Saudi Arabia between May 1, 2006, and July 1, 2011 (international series), and at the Jules Stein Eye Institute between May 1, 2004, and July 1, 2011 (University of California, Los Angeles [UCLA] series). Data were collected for each procedure regarding the preoperative characteristics of each eye, the surgical procedure(s) performed, and the postoperative outcomes. Statistical analysis was performed to identify significant differences between the international and UCLA series in terms of retention and complications. Interval visual acuities, keratoprosthesis retention, and significant postoperative complications. In the international series, 113 Boston type I keratoprostheses were implanted in 107 eyes of 100 patients. The most common indication for surgery was corneal graft failure (n = 50; 44%) followed by chemical injury (n = 30; 27%). Although only 2% of eyes had a preoperative corrected distance visual acuity (CDVA) of 20/20 to 20/200, 70%, 68%, and 59% of eyes had a postoperative CDVA of 20/20 to 20/200 at 6 months, 1 year, and 2 years after surgery, respectively. Ninety-one of the 113 keratoprostheses implanted (80.5%) were retained at a mean follow-up of 14.2 months, for a retention failure rate of 22 per 134.6 eye-years (0.163/eye-year). The most common postoperative complications were retroprosthetic membrane formation (27%) and sterile corneal necrosis (18%). The only postoperative complication

  5. Sucesos estresantes y sus impactos en mujeres y jóvenes de la comunidad de cuitzeo, Michoacán: El ciclo de la migración México-EUA en sus familias

    Directory of Open Access Journals (Sweden)

    Nydia Obregón-Velasco

    Full Text Available El presente trabajo describe algunos sucesos de vida estresantes y los impactos que tienen en la salud de las mujeres y sus hijos jóvenes, a partir de la migración hacia EUA de algunos de sus familiares directos, lo cual favorece el ciclo de migración en la familia. Se utilizó la metodología cualitativa con un enfoque de participación-acción, aplicando grupos focales, entrevistas y observación participante durante diferentes actividades realizadas en la comunidad de Cuitzeo, Michoacán, tales como conferencias y talleres.

  6. Registro e tecnovigilância de implantes dentários: panorama atual nos EUA, na União Europeia, no Brasil e sugestões de aprimoramento desses sistemas | Registry and surveillance of dental implants: current panorama in the USA, European Union, Brazil and suggestions for improved systems

    Directory of Open Access Journals (Sweden)

    Diana Ribeiro do Espírito Santo Jacomo

    2016-05-01

    Full Text Available O objetivo do presente trabalho foi comparar e analisar os requisitos necessários para registro e as ações de tecnovigilância para implantes dentários nos EUA, na União Europeia e no Brasil. Após análise da literatura e das principais normas em vigor, observou-se a preocupação com o controle de riscos e a prevenção de falhas no uso dos implantes dentários. Nos EUA, o sistema de registro e tecnovigilância é centralizado e se verificam problemas de subnotificação e falhas na análise dos relatórios de notificação, bem como um intervalo de tempo longo entre a identificação dos problemas e a ação devido à extensão do processo administrativo. Na União Europeia, os poucos estudos identificados sugerem que o sistema regulatório oferece riscos aos pacientes devido à ausência de transparência entre os Órgãos Notificadores e à dificuldade em se articular a tecnovigilância entre os países. No Brasil, a tecnovigilância é centralizada, porém ainda é incipiente. O envelhecimento da população promove forte demanda por reabilitação oral dos pacientes, sobretudo os carentes, prevista no programa Brasil Sorridente. A demanda pelo serviço oferece uma oportunidade de expansão do mercado, mas detecta-se risco de entrada de produtos de baixa qualidade. Neste contexto, o aprimoramento das atividades de tecnovigilância de implantes dentários é necessário. -------------------------------------------------------------------------------------------- This study compared and analyzed, after reviewing the literature and the main legal regulations, the requirements for registration and the post-marketing surveillance activities of dental implants in the USA, the European Union and in Brazil. The legal regulations studied showed a concern for risk control and for prevention of failures in the use of dental implants. In the US, the system is centralized, which produces underreporting problems and flaws in the analysis of

  7. O processo de mercantilização das instituições de educação superior: um panorama do debate nos EUA, na Europa e na América Latina The mercantilization proccess of higher education institutions: an overview of the debate in the U.S., Europe and Latin America

    Directory of Open Access Journals (Sweden)

    Milena Pavan Serafim

    2011-07-01

    Full Text Available O presente artigo apresenta as características gerais dos debates sobre o processo de mercantilização das instituições de educação superior nos EUA, na Europa e na América Latina. Parte da compreensão de que esse processo foi aprofundado e, em grande medida, acelerado pela "nova fase do capitalismo" e pelos reflexos das mudanças ideológicas mais amplas ligadas à ascensão do neoliberalismo. Ao visitar as questões debatidas sobre o processo de mercantilização da educação nesses países, o trabalho ressalta a dimensão ideológica por trás dele e contribui com os numerosos trabalhos acadêmicos que buscam contrapô-lo e que oferecem elementos para a reorientação da educação superior.This paper presents the general characteristics of the debate concerning the mercantilization proccess of higher education institutions in the USA, Latin America and Europe. It departs from the understanding that this proccess has been deepened and, to a great extent, has been accelerated during the current phase of capitalism and by the impacts of the broad ideological changes related to the rise of neoliberalism. By addressing the main questions regarding the mercantilization proccess in these countries, the paper stresses the ideological aspects behind it and contributes to the numerous works that seek to challenge it in the direction of another orientation for higher education.

  8. Morfologia e Crescimento dos 6 aos 10 anos de idade em Viana do Castelo, Portugal

    Directory of Open Access Journals (Sweden)

    Luis Paulo Rodrigues

    2008-09-01

    Full Text Available Ao longo de quatro anos, o Estudo Morfofuncional da Criança Vianense observou 1911 crianças entre os 6e os 10 anos de idade, resultando em 4064 observações individuais(2054 de raparigas, 2006 de rapazes.Os resultados encontrados nos indicadores morfológicos simples(altura, peso, pregas adiposas, diâmetros ósseos e perímetros muscularese no somatótipo, são descritos normativamente (valores percentílicose comparados com outros estudos nacionais e internacionais. As crianças vianenses demonstraram possuir uma estatura média ligeiramente superior às reportadas nos estudos portugueses e um ritmo de crescimento diferente das norte-americanas; peso semelhante ao das congéneres nacionais mas inferior ao das EUA; valores de pregas adiposas geralmente inferiores aos encontrados em Portugal e EUA; perímetros musculares e diâmetros ósseos semelhantes aos seus pares portugueses; e uma tendência para o aumento, com a idade, do ectomorfismo nos rapazes e do endomorfismo em ambos os sexos. Este panorama parece indicar que as crianças vianenses apresentam características de aptidão morfologia que estão longe de espelhar as preocupações internacionais nesta matéria.

  9. Completing the results of the 2013 Boston marathon.

    Science.gov (United States)

    Hammerling, Dorit; Cefalu, Matthew; Cisewski, Jessi; Dominici, Francesca; Parmigiani, Giovanni; Paulson, Charles; Smith, Richard L

    2014-01-01

    The 2013 Boston marathon was disrupted by two bombs placed near the finish line. The bombs resulted in three deaths and several hundred injuries. Of lesser concern, in the immediate aftermath, was the fact that nearly 6,000 runners failed to finish the race. We were approached by the marathon's organizers, the Boston Athletic Association (BAA), and asked to recommend a procedure for projecting finish times for the runners who could not complete the race. With assistance from the BAA, we created a dataset consisting of all the runners in the 2013 race who reached the halfway point but failed to finish, as well as all runners from the 2010 and 2011 Boston marathons. The data consist of split times from each of the 5 km sections of the course, as well as the final 2.2 km (from 40 km to the finish). The statistical objective is to predict the missing split times for the runners who failed to finish in 2013. We set this problem in the context of the matrix completion problem, examples of which include imputing missing data in DNA microarray experiments, and the Netflix prize problem. We propose five prediction methods and create a validation dataset to measure their performance by mean squared error and other measures. The best method used local regression based on a K-nearest-neighbors algorithm (KNN method), though several other methods produced results of similar quality. We show how the results were used to create projected times for the 2013 runners and discuss potential for future application of the same methodology. We present the whole project as an example of reproducible research, in that we are able to make the full data and all the algorithms we have used publicly available, which may facilitate future research extending the methods or proposing completely different approaches.

  10. Completing the results of the 2013 Boston marathon.

    Directory of Open Access Journals (Sweden)

    Dorit Hammerling

    Full Text Available The 2013 Boston marathon was disrupted by two bombs placed near the finish line. The bombs resulted in three deaths and several hundred injuries. Of lesser concern, in the immediate aftermath, was the fact that nearly 6,000 runners failed to finish the race. We were approached by the marathon's organizers, the Boston Athletic Association (BAA, and asked to recommend a procedure for projecting finish times for the runners who could not complete the race. With assistance from the BAA, we created a dataset consisting of all the runners in the 2013 race who reached the halfway point but failed to finish, as well as all runners from the 2010 and 2011 Boston marathons. The data consist of split times from each of the 5 km sections of the course, as well as the final 2.2 km (from 40 km to the finish. The statistical objective is to predict the missing split times for the runners who failed to finish in 2013. We set this problem in the context of the matrix completion problem, examples of which include imputing missing data in DNA microarray experiments, and the Netflix prize problem. We propose five prediction methods and create a validation dataset to measure their performance by mean squared error and other measures. The best method used local regression based on a K-nearest-neighbors algorithm (KNN method, though several other methods produced results of similar quality. We show how the results were used to create projected times for the 2013 runners and discuss potential for future application of the same methodology. We present the whole project as an example of reproducible research, in that we are able to make the full data and all the algorithms we have used publicly available, which may facilitate future research extending the methods or proposing completely different approaches.

  11. Experience with Boston keratoprosthesis type 1 in the developing world.

    Science.gov (United States)

    de Oliveira, Lauro Augusto; Pedreira Magalhães, Fernanda; Hirai, Flavio E; de Sousa, Luciene Barbosa

    2014-08-01

    To report the experience of the Federal University of São Paulo, Brazil, in performing Boston keratoprosthesis type 1 implantation in the developing world. We analyzed 30 eyes of 30 patients who underwent Boston type 1 keratoprosthesis surgery between 2008 and 2012 in a prospective interventional study. Preoperative, perioperative, and postoperative parameters were analyzed, including visual acuity (VA), keratoprosthesis stability, and postoperative complications. Preoperative diagnoses were failed grafts in 16 eyes (53.33%), chemical injury in 10 eyes (33.33%) and Stevens-Johnson syndrome in 4 eyes (13.33%). Also, 16 eyes (53.33%) had preoperative glaucoma. Preoperative best corrected VA ranged from 20/400 to light perception. With an average follow-up of 32 months (range 1-55 months), postoperative vision improved to >20/200 in 24 eyes (80%). Postoperative VA was statistically improved compared with the preoperative measurement during all postoperative follow-ups (up to 36 months). During the follow-up period (32 months), retention of the initial keratoprosthesis was 93.3%. The incidence of retroprosthetic membrane was 26.66%. Progression of glaucoma occurred in 7 of 16 eyes (43%). Three patients experienced development of glaucoma after keratoprosthesis implantation. One eye experienced development of infectious keratitis, and 2 eyes had retinal detachment. Performing Boston type 1 keratoprosthesis in a developing country is a viable option after multiple keratoplasty failures and conditions with a poor prognosis for keratoplasty. Our experience appears similar to major reports in the field from investigators in developed countries. Adjustments to postoperative management must be considered according to the particular location. Copyright © 2014 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

  12. Treatment of aniridia with Boston type I keratoprosthesis.

    Science.gov (United States)

    Rixen, Jordan J; Cohen, Alex W; Kitzmann, Anna S; Wagoner, Michael D; Goins, Kenneth M

    2013-07-01

    To report the outcomes of Boston keratoprosthesis (K-pro) type I implantation for congenital aniridia. A retrospective review of the medical records of every patient with congenital aniridia who underwent Boston K-pro type I implantation at the University of Iowa Hospitals and Clinics from January 1, 2009, through December 31, 2011 was performed. The main outcome measures were visual acuity, graft retention, and postoperative complications. A total of 7 eyes (7 patients) met the inclusion criteria. The mean patient age was 52 years (range, 12-85 years). The preoperative visual acuity was 20/1600 in 6 eyes (85.7%) and hand motions in 1 eye (14.3%). After a median follow-up period of 18 months (range, 3-30 months), the median final best spectacle-corrected visual acuity was 20/200 (range, 20/100 to light perception). This included 2 eyes (28.6%) that were 20/100 and 5 eyes (71.4%) that were better than 20/300. Compared with the preoperative best spectacle-corrected visual acuity, the final vision was improved in 6 eyes (85.7%) and worse in 1 eye (14.3%). The K-pro graft was retained in all 7 eyes (100%). The most common complication was the formation of a retroprosthetic membrane in 3 eyes (42.9%), none of which required either a YAG capsulotomy or a vitrectomy. One eye (14.3%) developed a wound dehiscence that required surgical repair. The Boston K-pro type I is a good option for the visual rehabilitation of eyes with congenital aniridia.

  13. Completing the Results of the 2013 Boston Marathon

    Science.gov (United States)

    Hammerling, Dorit; Cefalu, Matthew; Cisewski, Jessi; Dominici, Francesca; Parmigiani, Giovanni; Paulson, Charles; Smith, Richard L.

    2014-01-01

    The 2013 Boston marathon was disrupted by two bombs placed near the finish line. The bombs resulted in three deaths and several hundred injuries. Of lesser concern, in the immediate aftermath, was the fact that nearly 6,000 runners failed to finish the race. We were approached by the marathon's organizers, the Boston Athletic Association (BAA), and asked to recommend a procedure for projecting finish times for the runners who could not complete the race. With assistance from the BAA, we created a dataset consisting of all the runners in the 2013 race who reached the halfway point but failed to finish, as well as all runners from the 2010 and 2011 Boston marathons. The data consist of split times from each of the 5 km sections of the course, as well as the final 2.2 km (from 40 km to the finish). The statistical objective is to predict the missing split times for the runners who failed to finish in 2013. We set this problem in the context of the matrix completion problem, examples of which include imputing missing data in DNA microarray experiments, and the Netflix prize problem. We propose five prediction methods and create a validation dataset to measure their performance by mean squared error and other measures. The best method used local regression based on a K-nearest-neighbors algorithm (KNN method), though several other methods produced results of similar quality. We show how the results were used to create projected times for the 2013 runners and discuss potential for future application of the same methodology. We present the whole project as an example of reproducible research, in that we are able to make the full data and all the algorithms we have used publicly available, which may facilitate future research extending the methods or proposing completely different approaches. PMID:24727904

  14. Boston Community Energy Study - Zonal Analysis for Urban Microgrids

    Science.gov (United States)

    2016-03-01

    30 0.25 Solar Thermal 0 500 15 0.5 Air Source Heat Pump 0 70 10 0.52 Ground Source Heat Pump 0 80 10 0.32 is defined in Equation 3. For this analysis ...CHP can be used to provide nearly all of the required energy to a community, including electricity, heat , hot water , and cooling, assuming that the...or computers, 5 Figure 1. Building types in Boston. cooling electricity, gas heating , and gas hot water were simulated for every hour of the year for

  15. Na2EuAs2S5, NaEuAsS4, and Na4Eu(AsS4)2: controlling the valency of arsenic in polysulfide fluxes.

    Science.gov (United States)

    Bera, Tarun K; Kanatzidis, Mercouri G

    2012-04-02

    The reactivity of europium with As species in Lewis basic alkali-metal polysulfide fluxes was investigated along with compound formation and the As(3+)/As(5+) interplay vis-à-vis changes in the flux basicity. The compound Na(2)EuAs(2)S(5) containing trivalent As(3+) is stabilized from an arsenic-rich polysulfide flux. It crystallizes in the monoclinic centrosymmetric space group P2(1)/c. Na(2)EuAs(2)S(5) has [As(2)S(5)](4-) units, built of corner sharing AsS(3) pyramids, which are coordinated to Eu(2+) ions to give a two-dimensional (2D) layered structure. A sodium polysulfide flux with comparatively less arsenic led to the As(5+) containing compounds NaEuAsS(4) (orthorhombic, Ama2) and Na(4)Eu(AsS(4))(2) (triclinic, P1) depending on Na(2)S/S ratio. The NaEuAsS(4) and Na(4)Eu(AsS(4))(2) have a three-dimensional (3D) structure built of [AsS(4)](3-) tetrahedra coordinated to Eu(2+) ions. All compounds are semiconductors with optical energy gaps of ∼2 eV.

  16. U.S. Antidumping Policy as It Affects Negotiations RE ALCA/FTAA, NAFTA, and an Eventual WTO Round Title: La Política Antidumping de EUA y Sus Efectos en las Negociaciones del ALCA, TLCAN y una Eventual Nueva Ronda de Negociaciones de la OMC

    OpenAIRE

    Gary N. Horlick; Claire R. Palmer

    2002-01-01

    U.S. antidumping (AD) law is one of the core issues in all major international trade negotiations involving the United States over the next few years.Abstract: La ley antidumping (AD) de Estados Unidos (EUA) será uno de los temas centrales en todas las negociaciones de comercio internacional que involucren a Estados Unidos en los próximos años. Diversos países de América Latina y el Caribe han resuelto que la liberalización comercial negociada con EUA con frecuencia ha sido invalidada por las...

  17. Environmental benefits of Boston Harbor clean-up projects

    Energy Technology Data Exchange (ETDEWEB)

    Connor, M.S.; Smith, W.M. (Massachusetts Water Resources Authority, Boston (United States))

    1990-01-09

    The Massachusetts Water Resources Authority has undertaken one of the largest public works projects in the country to control the pollution of Boston Harbor. The project includes construction of a new primary and secondary treatment plant and sludge treatment facilities, excavation of a long ocean outfall and diffuser, and a solution to the overflow of mixed sewage and stormwater during storms; it will take over twenty years and billions of dollars to construct. A comparison of the relative costs and environmental benefits of relative costs and environmental benefits of the various construction projects, and other pollution control strategies, shows that some projects are more cost-effective than others for solving specific pollution problems. The capture and treatment of combined sewer overflow (CSO) will result in a more dramatic reduction of pathogen contamination than will completion of the primary and secondary treatment plants. Although the flow of raw sewage is intermittent and relatively small, it has high concentrations of bacteria and viruses. On the other hand, the new treatment plants will be more important in reducing toxic contamination of fish and shellfish. In summary, all the planned clean-up projects appear to be necessary to reach the goal of a swimmable, fishable Boston Harbor.

  18. Significance of Test-based Ratings for Metropolitan Boston Schools

    Directory of Open Access Journals (Sweden)

    Craig Bolon

    2001-10-01

    Full Text Available In 1998 Massachusetts began state-sponsored, annual achievement testing of all students in three public school grades. It has created a school and district rating system for which scores on these tests are the sole factor. It proposes to use tenth-grade test scores as a sole criterion for high school graduation, beginning with the class of 2003. The state is treating scores and ratings as though they were precise educational measures of high significance. A review of tenth-grade mathematics test scores from academic high schools in metropolitan Boston showed that statistically they are not. Community income is strongly correlated with test scores and accounted for more than 80 percent of the variance in average scores for a sample of Boston-area communities. Once community income was included in models, other factors--including percentages of students in disadvantaged populations, (Note 1 percentages receiving special education, percentages eligible for free or reduced price lunch, percentages with limited English proficiency, school sizes, school spending levels, and property values--all failed to associate substantial additional variance. Large uncertainties in residuals of school-averaged scores, after subtracting predictions based on community income, tend to make the scores ineffective for rating performance of schools. Large uncertainties in year-to-year score changes tend to make the score changes ineffective for measuring performance trends.

  19. HUBUNGAN FUZZY LOGIC DENGAN BOSTON CONSULTING GROUP UNTUK EVALUASI PRODUK

    Directory of Open Access Journals (Sweden)

    Titin Winarti

    2010-07-01

    Full Text Available Dalam perkembangan teknologi yang semakin pesat ini kebutuhan hari informasi yang benar akurat dan real sangat dibutuhkan oleh banyak orang. Dengan informasi, kita dapat melakukan apa yang akan kita lakukan ke depan dengan memiliki informasi. Informasi dapat menyediakan data yang relevan, akurat, dapat mengerti, pada jadwal untuk semua orang sehingga dapat dibuat untuk membuat keputusan. Fuzzy Logic dengan Boston Consulting Group digunakan untuk mengevaluasi produk untuk mendapatkan keputusan yang relevan Fuzzy Logic adalah metode diterapkan untuk mendukung proses evaluasi. Fuzzy Logic adalah metodologi yang telah ditetapkan dan secara luas digunakan untuk sistem model yang variabelnya bersifat kontinu, tidak pasti, atau ambigu. Ide utama dari Logika Fuzzy adalah bahwa hal-hal dalam dunia realitas yang lebih baik digambarkan dengan memiliki fungsi keanggotaan parsial pada pertemuan yang masing-masing saling melengkapi selain memiliki fungsi keanggotaan yang lengkap dalam sebuah pertemuan eksklusif. Proses evaluasi produk dilakukan sebagai berarti untuk menganalisis performansi produk di lapangan dilihat dari beberapa parameter tertentu. Output dari proses ini adalah mengevaluasi strategi rekomendasi untuk menjadi acuan dalam pengambilan keputusan atau rencana aksi untuk kelanjutan produk. Rencana Aksi ini merupakan strategi ini atau perlakuan yang akan diberlakukan untuk produk dievaluasi. Kata Kunci : Fuzzy Logic, Boston Consulting Group, Pengambilan Keputusan

  20. What We Learned about Urban Education Planning and Governance from the Boston School Desegregation Experience.

    Science.gov (United States)

    Willie, Charles V.

    1997-01-01

    Analyzes the lessons learned in urban education planning and governance that came out of Boston's three consecutive desegregation plans. Discusses how the community has profited from these plans as well as the implications the plans have for educational governance in Boston's public school system. (GR)

  1. Boston's Rapid Expansion of Public School-Based Preschool: Promoting Quality, Lessons Learned

    Science.gov (United States)

    Sachs, Jason; Weiland, Christina

    2010-01-01

    In his 2005 State of the City address, Boston Mayor Thomas Menino directed the Boston Public Schools (BPS) to "provide all 4-year-olds in the city with full-day school within five years." There were several reasons for this commitment, including an emerging consensus that early childhood education makes a positive difference in long-term…

  2. 75 FR 77693 - Noise Exposure Map Notice; Manchester-Boston Regional Airport, Manchester, NH

    Science.gov (United States)

    2010-12-13

    ... Federal Aviation Administration Noise Exposure Map Notice; Manchester-Boston Regional Airport, Manchester... Administration (FAA) announces its determination that the noise exposure maps for Manchester-Boston Regional... the noise exposure maps is December 3, 2010. FOR FURTHER INFORMATION CONTACT: Lisa J. Lesperance or...

  3. Historic fire regime dynamics and forcing factors in the Boston Mountains, Arkansas, USA

    Science.gov (United States)

    Richard P. Guyette; Martin A. Spetich; Michael C. Stambaugh

    2006-01-01

    We used dendrochronological methods to construct three fire history chronologies in the interior of the Boston Mountains of Arkansas from 281 dated fire scars identified on 86 shortleaf pine (Pinus echinata) remnants and trees. We describe and contrast these interior sites with sites on the southern perimeter of Boston Mountains that were documented in an earlier study...

  4. From Vision to Action: Solving Problems through Inquiry at Boston Day and Evening Academy

    Science.gov (United States)

    Kunst, Andrea

    2009-01-01

    On a mid-week day in mid-December 2008, Boston Day and Evening Academy's room 209, usually used for board meetings, student assessments, awards dinners, and other occasions requiring an intimate atmosphere, smelled like Chinese food. These second-trimester students at Boston Day and Evening Academy (BDEA) were having a reunion after just a few…

  5. 77 FR 56115 - Drawbridge Operation Regulations; Fort Point Channel, Boston, MA

    Science.gov (United States)

    2012-09-12

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Fort Point Channel, Boston, MA... of the Northern Avenue Bridge, mile 0.1, across the Fort Point Channel, at Boston, Massachusetts...: The Northern Avenue Bridge, across the Fort Point Channel, mile 0.1, has a vertical clearance in the...

  6. Boston type 1 keratoprosthesis for severe blinding vernal keratoconjunctivitis and Mooren's ulcer.

    Science.gov (United States)

    Basu, Sayan; Taneja, Mukesh; Sangwan, Virender S

    2011-06-01

    Indications for the Boston keratoprosthesis differ throughout the world depending on the prevailing regional causes of end-stage corneal disease. We report the short term anatomical and functional outcomes of the Boston type 1 keratoprosthesis for severe bilaterally blinding vernal keratoconjunctivitis and Mooren's ulcer. A retrospective chart review was conducted of 2 patients who underwent several unsuccessful ocular surface reconstruction procedures before Boston type 1 keratoprosthesis implantation. The anatomical and visual outcomes of the Boston type 1 keratoprosthesis at 1 year of follow-up were assessed clinically and by anterior segment optical coherence tomography imaging. The keratoprosthesis was retained in both the eyes at 1 year postoperatively with a best-corrected visual acuity of 20/30 in both patients. To our knowledge this is the first report of successful Boston keratoprosthesis implantation for these two unusual indications.

  7. 76 FR 23193 - Traffic Separation Schemes: In the Approaches to Portland, ME; Boston, MA; Narragansett Bay, RI...

    Science.gov (United States)

    2011-04-26

    ... Portland, ME; Boston, MA; Narragansett Bay, RI and Buzzards Bay, MA; Chesapeake Bay, VA, and Cape Fear... Portland, ME; in the approaches to Boston, MA; in the approaches to Narragansett Bay, RI and Buzzards Bay... Portland, ME; Boston, MA; Narragansett Bay, RI and Buzzards Bay, MA; Chesapeake Bay, VA; and Cape Fear...

  8. The Boston type I keratoprosthesis: improving outcomes and expanding indications.

    Science.gov (United States)

    Aldave, Anthony J; Kamal, Khairidzan M; Vo, Rosalind C; Yu, Fei

    2009-04-01

    To report the usefulness of the Boston type I keratoprosthesis (Massachusetts Eye and Ear Infirmary, Boston, MA) in the management of corneal opacification, corneal limbal stem cell failure, or both in a large single-surgeon series. Retrospective review of consecutive clinical case series. All patients undergoing keratoprosthesis implantation by a single surgeon (AJA) between May 1, 2004, and May 31, 2008. Data were collected regarding the preoperative characteristics of each eye undergoing keratoprosthesis implantation, the surgical procedure(s) performed, and the postoperative course. Statistical analysis was performed to identify factors influencing the incidence and severity of postoperative complications. Interval visual acuities, keratoprosthesis retention, and significant postoperative complications. Fifty-seven keratoprosthesis procedures were performed in 50 eyes of 49 patients. The primary indication for surgery was repeat corneal transplantation failure (68%), although no prior corneal surgery had been performed in 16% of eyes. Preoperative visual acuity was 20/200 or worse in all eyes, with 88% of eyes having preoperative vision of counting fingers, hand movements, or light perception. The percentage of eyes with postoperative visual acuity of 20/100 or better was 67% at 6 months (n = 45), 75% at 1 year (n = 28), 69% at 2 years (n = 13), and 100% at 3 years (n = 7). In the 31% of patients in whom preoperative vision in the contralateral eye was 20/50 or better, the postoperative vision in the operative eye improved to 20/50 or better in 47% at the last follow-up (average, 18 months; range, 4-49 months). The overall keratoprosthesis retention rate was 84% at an average follow-up of 17 months (79 person-years of follow-up), with 100% retention in 8 eyes with no history of prior corneal transplantation (14.8 person-years of follow-up). The most common postoperative complications were retroprosthetic membrane formation (22 eyes) and persistent epithelial

  9. Major Highlights of the CAR-TCR Summit, Boston, 2016.

    Science.gov (United States)

    Golubovskaya, Vita; Berahovich, Robert; Xu, Shirley; Harto, Hizkia; Wu, Lijun

    2017-01-01

    Cellular immunotherapies such as CAR-T cell therapy and TCR-T cell therapy are relatively new, highly promising approaches for the treatment of cancer. In CAR-T cell therapy, a patient's T cells are engineered to express chimeric antigen receptors targeting tumor-associated cell surface antigens. In TCR-T cell therapy, the patient's T cells are engineered to express receptors targeting intracellular antigens. This report will summarize presentations from the recent CAR-TCR summit in Boston on September 13-16, 2016. These presentations were given by leaders in the field and many were divided into three streams: Discovery and Genetic T Cell Engineering; Translation and Clinical Development; and Manufacturing, Supply Chain and Commercialization. The report summarizes major pharmaceutical companies developing these novel therapies and provides challenges and perspectives for future therapeutic developments. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  10. Research in particle physics. [Dept. of Physics, Boston Univ

    Energy Technology Data Exchange (ETDEWEB)

    Whitaker, Scott J.

    1992-09-01

    Research accomplishments and current activities of Boston University researchers in high energy physics are presented. Principal areas of activity include the following: detectors for studies of electron[endash]positron annihilation in colliding beams; advanced accelerator component design, including the superconducting beam inflector, electrostatic quadrupoles, and the electrostatic muon kicker''; the detector for the MACRO (Monopole, Astrophysics, and Cosmic Ray Observatory) experiment; neutrino astrophysics and the search for proton decay; theoretical particle physics (electroweak and flavor symmetry breaking, hadron collider phenomenology, cosmology and astrophysics, new field-theoretic models, nonperturbative investigations of quantum field theories, electroweak interactions); measurement of the anomalous magnetic moment of the muon; calorimetry for the GEM experiment; and muon detectors for the GEM experiment at the Superconducting Super Collider.

  11. Banco de Reserva Federal Boston - Massachusetts - EE.UU.

    Directory of Open Access Journals (Sweden)

    Stubbing, Hugh

    1979-10-01

    Full Text Available Despite its being located in a heavily built-up downtown area of Boston, the new Federal Reserve Bank Building enjoys privileged surroundings, in the middle of ponds and landscaped areas with trees, etc. It was designed taking the maximum advantage of the particular conditions of the property, while reinforcing and increasing prestige attributes of this part of the city, called for, in the urban development plans, to be the centre of community and business activities. The project includes an office tower overlooking the harbour and a low building containing ail public banking functions. The design was based on specific research of the different aspects of banking activities, from the most minute details of furniture and fixtures, through the fenestration work, up to the highly sophisticated security systems.

    Pese a estar situado en un área céntrica de Boston, en una zona densamente urbanizada, el nuevo edificio del Banco Federal goza de un entorno privilegiado, circundado por estanques y jardines con árboles. Su arquitectura procura sacar partido de las particulares características de la parcela, fortaleciendo y elevando la categoría de esa parte de ciudad a la que los planes urbanísticos asignan el papel de centro de actividades comunitarias y comerciales. La construcción cuenta con una torre de oficinas, con amplias vistas sobre el puerto, y un bloque bajo dedicado a actividades bancarias públicas. Para su realización se utilizaron los resultados de investigaciones específicas sobre los diversos aspectos de la actividad bancaria, comprendiendo desde los más pequeños detalles del mobiliario y de la carpintería exterior, hasta los más modernos y complejos sistemas de seguridad.

  12. Boston Type 1 Keratoprosthesis: Visual Outcomes, Device Retention, and Complications.

    Science.gov (United States)

    Goins, Kenneth M; Kitzmann, Anna S; Greiner, Mark A; Kwon, Young H; Alward, Wallace L M; Ledolter, Johannes; Wagoner, Michael D

    2016-09-01

    To determine the visual outcomes, device retention, and complications after Boston type 1 keratoprosthesis (KPro-1) device implantation. Comprehensive review of every case of KPro-1 implantation at a tertiary eye care center. The initial KPro-1 procedure, performed in 75 eyes without a previous keratoprosthesis, was included in the analysis. During the first 6 postoperative months, improvement occurred in the mean preoperative best-corrected visual acuity of 20/1265 to a mean best-obtained postoperative visual acuity of 20/97 (P < 0.001). After a mean follow-up period of 41.4 months (range, 0.8-82.8 months), the final mean best-corrected visual acuity was 20/428. Improved vision was recorded in 43 eyes (57.3%), ambulatory vision (≥20/400) in 47 eyes (62.7%), intermediate functional vision (≥20/80) in 23 eyes (30.7%), and full functional vision (≥20/40) in 11 eyes (14.7%). The initial device was retained in 64 eyes (85.3%), with a Kaplan-Meier retention probability of 96% at 6 months and 82% at 5 years. One or more sight-threatening complications occurred in 51 eyes (68%). These included device extrusion in 11 eyes (14.7%), ulcerative keratitis in 12 eyes (16%), endophthalmitis in 7 eyes (9.3%), sterile vitritis in 3 eyes (4%), retroprosthetic membranes in 25 eyes (33.3%), maculopathy in 26 eyes (34.7%), retinal detachment in 9 eyes (12%), and progressive optic neuropathy in 7 eyes (9.3%). Boston KPro-1 implantation is associated with satisfactory visual outcomes and excellent device retention in a majority of cases. However, serious postoperative complications are common and may compromise the final visual result.

  13. Shape modification of the Boston brace using a finite-element method with topology optimization.

    Science.gov (United States)

    Liao, Yi-Ching; Feng, Chi-Kuang; Tsai, Mei-Wun; Chen, Chen-Sheng; Cheng, Cheng-Kung; Ou, Yu-Chih

    2007-12-15

    Using a finite-element (FE) method to reshape the Boston brace, and evaluating the correction effect of the modified Boston brace in terms of Cobb angle. This study aimed to reduce the weight of the Boston brace using a FE method with topology optimization. The Boston brace is widely used to correct an abnormal spinal curve in adolescent idiopathic scoliosis. However, patients wearing the brace usually complain about discomfort caused by its bulkiness. An FE model of a traditional Boston brace was constructed using the software ANSYS 9.0. The loading condition was taken from an X-sensor measuring contact pressures between torso and brace. Topology optimization was conducted to modify the Boston brace. Three patients wearing a traditional brace and then the modified brace were examined in terms of Cobb angle. For the patient with King Type III scoliosis, this modified brace was able to offer the same correction effect as the traditional brace, but the modified brace was lighter by about 12.4%, with the potential to be up to 18% lighter. Based on the traditional Boston brace, this FE model, combined with topology optimization, can effectively estimate redundant material distribution and accordingly custom-design a lighter brace without any loss of its corrective effect.

  14. Posterior Pole Retinal Detachment Due to a Macular Hole in a Patient with a Boston Keratoprosthesis.

    Science.gov (United States)

    Gologorsky, Daniel; Williams, Basil K; Flynn, Harry W

    2017-04-01

    To describe the clinical course of a patient with a Boston Keratoprosthesis type I who developed a localized posterior pole retinal detachment secondary to a macular hole. A 73-year-old patient with a Boston Keratoprosthesis developed a localized posterior pole retinal detachment secondary to a macular hole. The retinal detachment was repaired with a 23-gauge pars plana vitrectomy, membrane peel, fluid-air exchange and 18% C3F8. Retinal reattachment was achieved but the macular hole remained open. A posterior pole retinal detachment secondary to a macular hole can be repaired using standard techniques despite the limited view through a Boston Keratoprosthesis.

  15. Phacoemulsification outcomes in Boston terriers as compared to non-Boston terriers: a retrospective study (2002-2015).

    Science.gov (United States)

    Newbold, Georgina M; Kelch, William J; Chen, Thomas; Ward, Daniel A; Hendrix, Diane V H

    2018-01-30

    To compare visual outcome and cause of blindness between two groups of dogs undergoing phacoemulsification. Study population consisted of 35 Boston terriers (BT; 70 eyes) and 77 non-Boston terriers (NBT; 154 eyes) that underwent bilateral phacoemulsification surgery. Medical records were reviewed to determine visual outcome, complications leading to blindness and follow-up. A Kaplan-Meier survival curve was used to estimate surgical success at 1 and 2 years postoperatively. Eleven of 35 BT developed known vision loss, with 12 of 70 (17.1%) eyes becoming blind within one year of surgery, and 17 of 77 NBT developed known vision loss, with 19 of 154 (12.3%) eyes becoming blind within 1 year of surgery. No further vision loss was reported among those BT with a 2-year follow-up. In the NBT group, seven additional dogs, a total of 24 of 77 NBT developed vision loss, with a known total of 31 of 154 (20.1%) eyes becoming blind within two years of surgery. These results were not significantly different. The overall surgical success in both groups based on individual eyes was estimated to be between 80 and 90% at 1 year postsurgery and between 65 and 80% at 2 years postsurgery. Glaucoma was the leading cause of vision loss in both groups. There was no significant difference in visual outcomes between a group of BT and a group of NBT undergoing bilateral phacoemulsification at the University of Tennessee between 2002 and 2015. Glaucoma was the leading cause of vision loss in both groups. © 2018 American College of Veterinary Ophthalmologists.

  16. The New England Drought Study: Water Resources Planning Metropolitan Boston, Massachusetts

    National Research Council Canada - National Science Library

    Joyce, Charles

    1994-01-01

    The study has traced the water resources planning experience for the metropolitan Boston area from the 17th century to the present in order to investigate how current planning has evolved from seeking...

  17. Endoscopic Cyclophotocoagulation for the Treatment of Glaucoma in Boston Keratoprosthesis Type II Patient

    Science.gov (United States)

    Poon, Linda Yi-Chieh; Chodosh, James; Vavvas, Demetrios G.; Dohlman, Claes H.

    2017-01-01

    We describe the surgical technique of endoscopic cyclophotocoagulation in a Boston keratoprosthesis type II patient. This patient with ocular cicatricial pemphigoid had pars plana endoscopic cyclophotocoagula through wounds created in the eyelids. PMID:28079656

  18. Polymers and Liquid Crystals Symposium held in Boston, Massachusetts on August 19-23, 2007 (Abstracts)

    National Research Council Canada - National Science Library

    Gin, Douglas L

    2007-01-01

    This grant was used to provide partial travel assistance for 5 invited speakers for a POLY Division symposium titled "Polymers and Liquid Crystals" at the Fall 2007 ACS National Meeting in Boston, MA (Aug. 19-23, 2007...

  19. Impact of the Boston Marathon Bombing and Its Aftermath on Refugees and Survivors of Torture.

    Science.gov (United States)

    Piwowarczyk, Linda; Rous, Dana; Mancuso, Anna; Flinton, Kathleen; Hastings, Erica; Forbush, Leigh; Shepherd, Amy

    2016-08-01

    On April 15, 2013, Boston residents and guests gathered for the Boston Marathon. Two explosives at the finish line killed three people and injured hundreds of others. As part of our clinical encounters, patients of the Boston Center for Refugee Health & Human Rights were asked about the marathon bombing. We were concerned about the high level of armed security as many of our patients had been detained in their countries of origin. Eighty patients seen between April 16 and July 7, 2013 were asked about their experience of the Boston Marathon bombing and its aftermath. A retrospective chart review was undertaken and data analyzed using Atlas.ti & SPSS. Approximately 86 % of those interviewed were reminded of their past trauma. The following themes emerged: triggering and trauma related symptoms, content specific cognitive schemas, recognition of the universality of violence, fears of discrimination, issues surrounding safety, and specific concerns of Muslims.

  20. Threat perception after the Boston Marathon bombings: The effects of personal relevance and conceptual framing.

    Science.gov (United States)

    Wormwood, Jolie Baumann; Lynn, Spencer K; Feldman Barrett, Lisa; Quigley, Karen S

    2016-01-01

    We examined how the Boston Marathon bombings affected threat perception in the Boston community. In a threat perception task, participants attempted to "shoot" armed targets and avoid shooting unarmed targets. Participants viewing images of the bombings accompanied by affectively negative music and text (e.g., "Terror Strikes Boston") made more false alarms (i.e., more errors "shooting" unarmed targets) compared to participants viewing the same images accompanied by affectively positive music and text (e.g., "Boston Strong") and participants who did not view bombing images. This difference appears to be driven by decreased sensitivity (i.e., decreased ability to distinguish guns from non-guns) as opposed to a more liberal bias (i.e., favouring the "shoot" response). Additionally, the more strongly affected the participant was by the bombings, the more their sensitivity was reduced in the negatively framed condition, suggesting that this framing was particularly detrimental to the most vulnerable individuals in the affected community.

  1. Radiologic features of injuries from the Boston Marathon bombing at three hospitals

    National Research Council Canada - National Science Library

    Singh, Ajay K; Goralnick, Eric; Velmahos, George; Biddinger, Paul D; Gates, Jonathan; Sodickson, Aaron

    2014-01-01

    The aim of this study is to describe the radiologic imaging findings of primary, secondary, tertiary, and quaternary blast injuries in patients injured in the Boston Marathon bombing on April 15, 2013...

  2. Short-term outcome of Boston Type 1 keratoprosthesis for bilateral limbal stem cell deficiency

    Directory of Open Access Journals (Sweden)

    Sayan Basu

    2012-01-01

    Full Text Available This study reports the short-term functional and anatomical outcome of Boston Type 1 keratoprosthesis (Boston Kpro implantation for bilateral limbal stem cell deficiency (LCSD. Retrospective analysis was done on eight eyes of eight patients who underwent Boston Kpro implantation between July 2009 and October 2009. The best corrected visual acuity (BCVA and slit-lamp biomicroscopy findings were assessed at 1, 3 and 6 months postoperatively. All eight eyes retained the prosthesis. BCVA of 20/40 or better was achieved in 8, 6, and 5 eyes at 1, 3, and 6 months, respectively, postoperatively. One patient each developed epithelial defect, sterile stromal melt and fungal keratitis in the late postoperative period associated with antecedent loss of the soft contact lens from the eye. Boston Kpro has good short-term visual and anatomical outcome in patients with bilateral LSCD, provided compliance with postoperative care can be ensured.

  3. EPA Administrator McCarthy in Boston with Canada and Mexico for Commission on Environmental Cooperation

    Science.gov (United States)

    BOSTON, MA; WASHINGTON - On Tuesday and Wednesday, U.S. Environmental Protection Agency Administrator Gina McCarthy will host Mexican Environment Deputy Secretary Dr. Rodolfo Lacy Tamayo representing Secretary Juan José Guerra Abud and Canadian E

  4. Influência da enxertia nas trocas gasosas de dois híbridos de berinjela cultivados em ambiente protegido

    Directory of Open Access Journals (Sweden)

    Brandão Filho José Usan T.

    2003-01-01

    Full Text Available Compararam-se os efeitos da enxertia nas trocas gasosas de dois híbridos de berinjela em pé franco e enxertado. Conduziu-se um ensaio em ambiente protegido, na FCA/UNESP, em estrutura simples, tipo arco com 7 m de largura, 40 m de comprimento e 3 m de pé direito, cobertos por filme plástico de 100 micrometros. Foram utilizados os híbridos de berinjela Nápoli e Kokuyo, enxertados em porta-enxerto específico (híbrido Taibyo VF para esta espécie. O delineamento experimental utilizado foi inteiramente casualizado, com quatro tratamentos (Nápoli pé franco, Nápoli enxertada, Kokuyo pé franco e Kokuyo enxertada com dez repetições. A assimilação líquida de CO2 (A, transpiração (E, condutância estomática (g s e eficiência no uso de água (EUA, obtida pela relação (A/E, foram determinadas às 09:00; 12:00; 14:00 e 16:00 horas em um dia sem nebulosidade com fluxo de fótons fotossinteticamente ativos (FFFA de 937±126 mmol m-2 s-1, com um sistema fechado portátil de fotossíntese, IRGA, modelo LI-6200 (LI-COR. Observou-se que as plantas do híbrido Kokuyo apresentaram maiores valores para as variáveis A, E, g s e EUA que o híbrido Nápoli. A enxertia não afetou a capacidade fotossintética dos híbridos, porém, esta resultou em menores valores de E e g s nos dois híbridos, levando à maior EUA, efeito este que na prática pode resultar em menor demanda de água pelas plantas.

  5. Vision Restoration with a Collagen Cross-linked Boston Keratoprosthesis Unit

    Science.gov (United States)

    2017-09-01

    AWARD NUMBER: W81XWH-15-2-0044 TITLE: Vision Restoration with a Collagen Crosslinked Boston Keratoprosthesis Unit PRINCIPAL INVESTIGATOR: Joseph B...AND SUBTITLE 5a. CONTRACT NUMBER Vision Restoration with a Collagen Cross-linked Boston Keratoprosthesis Unit 5b. GRANT NUMBER W81XWH-15-2-0044 5c...Unfortunately, the most common cause of keratoprosthesis failure is due to corneal melts, which can lead to permanent vision loss. We have developed a

  6. Terrorism, governmentality and the simulated city: the Boston Marathon bombing and the search for suspect two

    OpenAIRE

    Topinka, Robert

    2016-01-01

    This article examines the online circulation of a photograph of the immediate aftermath of the 2013 Boston Marathon bombings taken by David Green, a Boston Marathon runner. The photograph fortuitously captured an image of Dzhokhar Tsarnaev, the younger Tsarnaev brother, running from the scene. Initially, Tsarnaev went unnoticed by online message board users and FBI investigators – he was just another face in the urban crowd. However, after he was identified as suspect two, he emerged in the p...

  7. Avaliação reprodutiva de machos de camarão rosa Farfantepenaeus duorarum cultivados em sistema BFT “Bio-Floc Tecnology”

    OpenAIRE

    López, Miguel Arévalo

    2010-01-01

    Dissertação(mestrado)-Universidade Federal do Rio Grande, Programa de Pós-Graduação em Aqüicultura, Instituto de Oceanografia, 2010. O camarão-rosa Farfantepenaeus duorarum é um importante recurso pesqueiro que apresenta distribuição no Oceano Atlântico desde o estado de Maryland nos EUA até a Bahia de Ascensión, no estado de Quintana Roo no México. O objetivo do presente trabalho foi avaliar a qualidade reprodutiva e nutricional de machos mediante a contagem e caracterização de células es...

  8. O desafio do desenvolvimento frente aos marcos ecológico e de mercado em direção à sustentabilidade no século XXI

    Directory of Open Access Journals (Sweden)

    Gustavo Madeira da Silveira

    2010-12-01

    Full Text Available Neste trabalho demonstrar-se-á o desafio do modelo desenvolvimentista atual em direção à preconizada e colimada sustentabilidade. A primeira década deste século XXI foi marcada por dois marcos, um ambiental (as mudanças climáticas e outro de mercado (a crise econômica mundial, que colocaram em cheque o sistema capitalista, tendo em vista as soluções insustentáveis que foram tomadas para enfrentar estes marcos. Foram objeto de análise da pesquisa, a não adesão dos EUA ao Protocolo de Quioto; o contraponto dos países “em desenvolvimento” entre desenvolver-se ora sustentavelmente, ora insustentavelmente; e o fomento do consumo como única alternativa encontrada pelo países para a saída da crise econômica mundial.

  9. Impactos de medidas “antidumping” adotadas pelos EUA sobre o setor siderúrgico de Minas Gerais e o restante do Brasil

    Directory of Open Access Journals (Sweden)

    Vinícius de Azevedo Couto Firme

    2012-11-01

    Full Text Available Analisar o impacto de medidas antidumping aplicadas pelos Estados Unidos sobre exportações do setor siderúrgico de Minas Gerais, para o período entre 1999 e 2002, foi o objetivo deste trabalho. Os resultados mostraram que tal medida teve efeitos estatisticamente significativos sobre a redução no fluxo de comércio. Na análise da integração dos resultados econométricos com a abordagem de matrizes inter-regionais de insumo-produto, foi possível concluir que o setor mais afetado, no que se refere à produção, seria a siderurgia mineira, em que o impacto representou mais de 75% do total, no período em análise. Com relação ao emprego, o impacto sobre a siderurgia de Minas Gerais corresponde, em média, a mais de 50% do total de vagas que seriam criadas, caso nenhuma medida antidumping tivesse sido adotada; e a siderurgia do restante do país seria responsável por mais de 16% dos postos de trabalho criados no período.

  10. Personal Hygiene Practices among Urban Homeless Persons in Boston, MA.

    Science.gov (United States)

    Leibler, Jessica H; Nguyen, Daniel D; León, Casey; Gaeta, Jessie M; Perez, Debora

    2017-08-18

    Persons experiencing homelessness in the United States experience significant barriers to self-care and personal hygiene, including limited access to clean showers, laundry and hand washing facilities. While the obstacles to personal hygiene associated with homelessness may increase risk of infectious disease, hygiene-related behaviors among people experiencing homelessness has received limited attention. We conducted a cross-sectional study of individuals experiencing homelessness in Boston, MA ( n = 194) to identify hygiene-related self-care practices and risk factors for reduced hygiene in this population. Most participants (72%) reported taking a daily shower. More than 60% reported hand washing with soap five or more times each day, and use of hand sanitizer was widespread (89% reported using sanitizer in the last week). A majority (86%) used a laundromat or laundry machine to wash clothing, while 14% reported washing clothing in the sink. Heavy drinking, injection drug use, and sleeping outdoors were identified as significant risk factors for reduced hygiene practices. People experiencing homelessness who also engage in these activities may be among the most difficult to reach for intervention, yet targeted efforts may decrease illness risk associated with reduced hygiene. Housed friends and family play a critical role in assisting homeless individuals maintain hygiene by providing showers and laundry facilities.

  11. Is the Boston Naming Test still fit for purpose?

    Science.gov (United States)

    Harry, Alexandra; Crowe, Simon F

    2014-01-01

    The Boston Naming Test (BNT) (Kaplan, Goodglass, & Weintraub, 1983) is the most commonly used test of confrontation naming in neuropsychology (Rabin, Barr, & Burton, 2005). However, there are significant criticisms of the BNT which suggest that it might not be the assessment measure of choice. These criticisms are that the BNT has poor psychometric properties, is not adequately standardized, and has inadequate norms. It is further suggested that when considered in the context of contemporary conceptualizations of the neuropsychology of naming, the BNT does not adequately capture the processes known to be required for successful naming, and does not sample widely enough from the content domain of "naming". These criticisms suggest that the BNT is flawed as a measure of naming, and are discussed in detail in this review. Other stand-alone visual confrontation naming tasks are reviewed to evaluate whether any might be viable substitutes for the BNT in clinical neuropsychology. The Naming Test from the Neuropsychological Assessment Battery (Stern & White, 2009) was identified as a possible alternative to the BNT, however, neither of these tests was designed with reference to models of the neuropsychology of naming, and development of a new test of naming is indicated.

  12. Building a culture of excellence in Boston and beyond.

    Science.gov (United States)

    Hickey, Patricia A

    2010-10-01

    There is mounting evidence that unhealthy work environments result in dissatisfied staff, breakdown in communication among disciplines, and poor patient outcomes. The American Association of Critical Care Nurses (AACN) Standards for Establishing and Sustaining Healthy Work Environments and the American College of Chest Physicians (ACCP) Patient-Focused Care project were developed as complementary initiatives to provide direction for improving patient care environments. Hospitalized pediatric patients benefit from interdisciplinary collaboration, teamwork, and clinical innovation that are not obstructed by disciplinary silos and rigid roles. AACN's 6 evidence-based standards are used as a framework to guide this discussion about cultures of excellence in pediatric cardiovascular programs through the lens of an experienced nurse administrator. Each standard interacts in a dynamic way to promote clinical and operational excellence for optimal patient outcomes. Evidence-based examples of contemporary interdisciplinary practice from pediatric cardiovascular centers are described for each of the standards. The 2010 results from the AACN Healthy Work Environment Survey for the cardiovascular program at Children's Hospital Boston are documented. The AACN standards are aligned as a foundation for assessment and improvement of pediatric professional practice environments. Implementation of the standards may be helpful in achieving a culture of excellence in pediatric cardiovascular centers. Monitoring the standards across programs and organizations may be accomplished through the AACN Healthy Work Environment Survey.

  13. Sediment quality assessment studies in Boston Harbor, Massachusetts

    Energy Technology Data Exchange (ETDEWEB)

    Carr, R.S.; Chapman, D.C.; Biedenbach, J.M. [National Biological Service, Corpus Christi, TX (United States). Texas Gulf Coast Field Station; Long, E.R. [NOAA, Seattle, WA (United States); Thursby, G. [Science Applications International Corp., Narragansett, RI (United States); MacDonald, D.D. [MacDonald Environmental Sciences Ltd., Ladysmith, British Columbia (Canada)

    1995-12-31

    As part of NOAA`s National Status and Trends program, a bioeffects assessment study was conducted in the vicinity of Boston Harbor, Massachusetts. Surficial sediment samples were collected at 55 sites and subsamples were tested for toxicity using (1) the 10-day whole sediment test with Ampelisca abdita, (2) the sea urchin (Arbacia punctulata) fertilization and embryological development assays with sediment pore water, and (3) Microtox{trademark} assay with organic sediment extracts. Eleven percent of the samples were significantly toxic in the amphipod test, only 4% were toxic in the sea urchin fertilization test whereas all of the samples were highly toxic in the sea urchin embryological development assay; the Microtox assay determined 56% of the organic sediment extracts to be significantly toxic. Sediment chemical analyses for metals, AVS/SEM, PAHs, PCBs, and pesticides were performed on 30 of the 55 samples. Twenty-seven of the 30 samples exceeded at least one probable effects level (PEL) value. For the 20 samples that exceeded 5 or more PELS, the concordance between the predicted and observed toxicity was 20% for the amphipod test, 60% for the Microtox test, and 100% for the sea urchin embryological development assay. There were no significant correlations among the different toxicity tests or between the tests and the contaminant concentrations in the bulk sediment. Possible explanations for the apparent lack of correlation between the sediment chemistry and the toxicity tests will be discussed.

  14. Oral Acetazolamide after Boston Keratoprosthesis in Stevens Johnson Syndrome

    Science.gov (United States)

    2012-01-01

    Background Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare but severe and sometimes fatal condition associated with exposure to medications; sulfamethoxazole is among the most common causes. We sought to address the safety of acetazolamide, a chemically related compound, in patients with prior SJS/TEN and glaucoma. A retrospective case series is described of patients at the Massachusetts Eye and Ear Infirmary who underwent keratoprosthesis surgery for corneal blindness from SJS/TEN, and later required oral acetazolamide for elevated intraocular pressure. Findings Over the last 10 years, 17 patients with SJS/TEN received a Boston keratoprosthesis. Of these, 11 developed elevated intraocular pressure that required administration of oral acetazolamide. One of 11 developed a mild allergic reaction, but no patient experienced a recurrence of SJS/TEN or any severe adverse reaction. Conclusion Although an increase in the rate of recurrent SJS/TEN due to oral acetazolamide would not necessarily be apparent after treating only 11 patients, in our series, acetazolamide administration was well tolerated without serious sequela. PMID:22546532

  15. Oral Acetazolamide after Boston Keratoprosthesis in Stevens Johnson Syndrome

    Directory of Open Access Journals (Sweden)

    Kumar Radhika

    2012-04-01

    Full Text Available Abstract Background Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN is a rare but severe and sometimes fatal condition associated with exposure to medications; sulfamethoxazole is among the most common causes. We sought to address the safety of acetazolamide, a chemically related compound, in patients with prior SJS/TEN and glaucoma. A retrospective case series is described of patients at the Massachusetts Eye and Ear Infirmary who underwent keratoprosthesis surgery for corneal blindness from SJS/TEN, and later required oral acetazolamide for elevated intraocular pressure. Findings Over the last 10 years, 17 patients with SJS/TEN received a Boston keratoprosthesis. Of these, 11 developed elevated intraocular pressure that required administration of oral acetazolamide. One of 11 developed a mild allergic reaction, but no patient experienced a recurrence of SJS/TEN or any severe adverse reaction. Conclusion Although an increase in the rate of recurrent SJS/TEN due to oral acetazolamide would not necessarily be apparent after treating only 11 patients, in our series, acetazolamide administration was well tolerated without serious sequela.

  16. Imaging of lower extremity trauma from Boston Marathon bombing.

    Science.gov (United States)

    Konwinski, Ryan R; Singh, Ajay; Soto, Jorge

    2016-10-01

    The goal of this study is to describe the imaging features of lower extremity blast injuries in patients encountered in the radiology departments from the Boston Marathon bombings. A total of 115 patients presented to four acute care hospitals on April 15, 2013, 43 of whom presented with lower extremity injuries and were included in this study. The imaging findings of primary, secondary, tertiary, and quaternary blast injuries were evaluated. Forty-one of 43 patients sustained secondary blast injuries to the lower extremities with 31 patients (70 %) having retained shrapnel, seven patients (16 %) having soft tissue lacerations without retained shrapnel, and ten patients (23 %) having lower extremity amputation (7 % double amputees). Eight of these patients (20 %) had lower extremity fractures, and five patients (12 %) had vascular injuries. Two of the 43 patients (5 %) had only tertiary injuries, and five of 43 patients (12 %) were noted to have lower extremity burns, consistent with quaternary blast injury. No primary blast injury occurred in the lower extremities. A vast majority of lower extremity injuries were from secondary blast injury, most commonly from retained shrapnel in 70 % of patients and 23 % of patients sustaining lower extremity amputation. Retained shrapnel in the lower extremity was most commonly ball bearings and pressure cooker fragments, and most injuries affected the leg, followed by the thigh and foot.

  17. Measuring Boston’s Security Investment: Methods and Tools to Assess Homeland Security Initiatives. Policy Analysis Exercise

    Science.gov (United States)

    2009-03-31

    Balanced Scorecard . Boston: Harvard Business School Press, 1996. Kaplan , Robert, and David Norton . Strategy Maps. Boston: Harvard Business School... Norton , The BalancedScorecard (Boston: Harvard Business School Press, 1996). 9 Paul Niven, Balanced Scorecard Step-By-Step For Government and Nonprofit...strategy. Developed in the 1990s by Robert Kaplan and David Norton18, the Balanced Scorecard made waves in the private sector, replacing simple

  18. Race and the Metropolitan Origins Of Postsecondary Access to Four Year Colleges: The Case of Greater Boston

    OpenAIRE

    Berger, Joseph B.; Smith, Suzanne M.; Coelen, Stephen P.

    2004-01-01

    The Metro Boston Equity Initiative is devoted to analyzing race relations and racial equity issues not simply in the city of Boston, but across the entire metropolitan region. Although greater Boston still has a large white majority and suburban sectors with very little diversity, immigration of Latinos and Asians is driving the region’s growth, and much of this population increase is taking place well outside of the city limits. Changing patterns of school enrollment provide a good sense of ...

  19. The resumption of diplomatic ties between Cuba and the United States: between the end of the Cold War and the normalization of relations? / A retomada dos laços diplomáticos entre Cuba e EUA: entre o fim da Guerra Fria e a normalização das relações?

    Directory of Open Access Journals (Sweden)

    Marcos Antonio da Silva

    2017-03-01

    Full Text Available The present paper discusses the reestablishment of diplomatic relations between Cuba and the USA, made official in 2014, seeking to analyze its dynamics and the challenges that hinder its effective normalization. In order to do so, it discusses the motivations that led to this process and determined the resumption of diplomatic ties, which had been broken since the beginning of the 1960s, replacing, albeit partially, the conflicting politics that had prevailed in this relationship. It then analyzes the perceptions and main actions since the announcement of such resumption and discusses the demands presented by each party for an effective normalization. In this sense, it presents the Cuban demands (end of the economic embargo, reparations of resources, open and transparent relations, end of programs destined to deprive government of the country, among others and the American demands (political and economic reforms, civil society and human rights, Indemnities, forms of property, among others, trying to demonstrate that there is a long way to go until the effective normalization of such relationship. Such a path will be determined both by the solution to such demands and by the dynamics of the domestic politics of each country that may or may not lead to overcoming the logic of the conflict that had prevailed. O presente trabalho discute o restabelecimento das relações diplomáticas entre Cuba e EUA, oficializado em 2014, procurando analisar sua dinâmica e os desafios para uma normalização efetiva. Para tanto, discute as motivações, de parte a parte, que conduziram a este processo e determinaram a retomada dos laços diplomáticos, rompidos desde princípios dos anos 60, substituindo, ainda que parcialmente, a política conflituosa que havia imperado em tal relação. Em seguida, analisa as percepções e as principais ações desde o anúncio de tal retomada e discute as demandas apresentadas por cada parte para uma efetiva normaliza

  20. Boston type 1 keratoprosthesis outcomes in ocular burns.

    Science.gov (United States)

    Magalhães, Fernanda Pedreira; Hirai, Flavio Eduardo; de Sousa, Luciene Barbosa; de Oliveira, Lauro Augusto

    2013-09-01

    To report the outcomes of Boston type I keratoprosthesis (BKPro) in the management of ocular burn injuries. This was a prospective study including all cases of BKPro implantation for ocular burns at the External Diseases and Cornea Service of the Federal University of São Paulo, between February 2008 and February 2010. Ten patients (10 eyes) were enrolled. Procedures performed to manage ocular injury were identified, and data were collected regarding patients' ocular history, surgical procedure(s) performed, and postoperative outcomes, including visual acuity, retention, complications and required surgical procedures. A total of 11 Type 1 BKPro were implanted in 10 eyes of 10 patients. The mean follow-up period was 25.7 ± 10.8 months. Preoperative best-corrected visual acuity (BCVA) ranged from count fingers to light perception. Postoperative BCVA was better than 20/200 in 90% of the patients and better than 20/60 in 60% of the patients. The overall BKPro retention rate was 90%. The most common complications were retroprosthetic membrane formation (50%) and persistent corneal epithelial defect evolving to corneal melting (40%). Patients who underwent ocular surface procedures such as limbal transplantation prior to BKPRo implantation had a lower incidence of corneal melting/thinning (p = 0.07), although this was not statistically significant. The anatomical and functional results identified in this study support the use of BKPro in managing bilateral limbal stem cell deficiency secondary to ocular burns. © 2013 The Authors. Acta Ophthalmologica © 2013 Acta Ophthalmologica Scandinavica Foundation. Published by Blackwell Publishing Ltd.

  1. No Light Perception Outcomes Following Boston Keratoprosthesis Type 1 Surgery.

    Science.gov (United States)

    Muzychuk, Adam K; Durr, Georges M; Shine, Julien J; Robert, Marie-Claude; Harissi-Dagher, Mona

    2017-09-01

    To determine the incidence rate, principal causes, and clinical course of eyes developing no light perception (NLP) visual acuity (VA) following Boston Keratoprosthesis (B-KPro) type 1 surgery. Secondary objectives include determining the incidence rate, relative risk (RR), and survival probability with respect to NLP outcomes among eyes with congenital aniridia. Retrospective, interventional case series. All patients undergoing B-KPro type 1 surgery between October 2008 and June 2016 by a single surgeon at CHUM - Hôpital Notre-Dame. Records of patients having undergone B-KPro implantation were reviewed. Eyes with a final outcome of NLP were further reviewed to determine best recorded postoperative VA, time to NLP onset, clinical course, and principal cause. Descriptive statistics, incidence rates, Kaplan-Meier survival curves, and the RR of NLP outcomes among eyes with aniridia were determined. Statistical significance was defined as P NLP, representing 16.0%. The incidence rate of NLP was 0.04 cases per eye-year of follow-up. The most common principal causes were inoperable retinal detachment (n = 7, 36.8%), terminal glaucoma (n = 6, 31.6%), and carrier graft melt-related complications (n = 5, 26.3%). The RR of developing NLP among eyes with aniridia was 3.04 (P = .01). No light perception is a devastating but uncommon outcome of B-KPro surgery. Patients with aniridia seem to be at increased risk. In spite of all available medical and surgical interventions, some eyes may still suffer this outcome. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Wide-angle fundus imaging through the Boston keratoprosthesis.

    Science.gov (United States)

    Sayegh, Rony R; Dohlman, Claes H

    2013-06-01

    To explore the feasibility and compare the outcomes of three wide-angle fundus cameras for imaging the peripheral retina through the Type 1 Boston keratoprosthesis. The noncontact Optos and the contact RetCam and Panoret wide-angle imaging systems were used to image the retina of eyes implanted with a keratoprosthesis. The failure-to-image rate, ease of acquisition, and quality of the images were noted, and the field of view was compared. Limitations and complications were recorded. Optos was then performed on patients referred for ultrasound B-scan evaluation, and the imaging findings were correlated. Retinal images with all three cameras were obtained on four eyes. Optos could be performed on all four eyes, RetCam on three, and Panoret on two. The field of view was comparable between the three different cameras. The best quality images were obtained with Optos. The external illumination of the Panoret made it impossible to image the only darkly pigmented individual in the series. Both contact devices failed to image another patient who was too agitated. Two patients had some ocular irritation from the coupling agent that resolved with replacement of the contact lens. Optos images were obtained on an additional six eyes, and findings correlated well with those on B-scan. Optos was superior to B-scan in an eye with silicone oil filling. Wide-angle fundus imaging through the keratoprosthesis is possible, and all three cameras performed similarly. The good quality of pictures obtained with the noncontact Optos, as well as its ease of use, comfort, and safety make it a preferred choice. Optos complements B-scan in the examination of the peripheral retina through the keratoprosthesis, and it may even be superior in certain settings.

  3. The Boston keratoprosthesis provides a wide depth of focus.

    Science.gov (United States)

    Sayegh, Rony R; Dohlman, Claes H; Greenstein, Scott H; Peli, Eli

    2015-01-01

    To measure the through-focus curve for eyes implanted with a type 1 Boston keratoprosthesis (KPro) and compare it to that of pseudophakic controls with fixed pupil sizes. The results should assist in evaluating postoperative visual quality after surgery. They should also help to determine the necessary KPro inventories in terms of refractive power steps. Autorefraction and manifest refraction were performed on all eyes. The monocular through-focus acuity curve was plotted in reference to the best-corrected visual acuity by spectacle plane defocus ranging from +5.00 to -5.00 dioptres in 0.50 dioptre increments. These measurements were obtained on KPro-implanted eyes, pseudophakic eyes as controls, and on the same control eyes after fixing the pupil diameter to 3 and 2 mm using black painted iris contact lenses. Ten KPro eyes and five control eyes were included. Good agreement was noted between the subjective refractions and autorefraction in KPro eyes. The average through-focus curve for the control eyes was significantly steeper than that of the KPro curve, but became comparable after fixing the control pupil to 2 and 3 mm. The KPro's wide depth-of-focus makes the visual acuity less dependent on an exact refractive correction at distance and explains the 'pseudoaccomodation' experienced by these patients. This is primarily due to the small pupil diameter of the KPro. The current manufacturing steps in 0.50 dioptre increments appears to be sufficient. © 2014 The Authors Ophthalmic & Physiological Optics © 2014 The College of Optometrists.

  4. Idiopathic vitritis in the setting of Boston keratoprosthesis.

    Science.gov (United States)

    Grassi, Christina M; Crnej, Alja; Paschalis, Eleftherios I; Colby, Kathryn A; Dohlman, Claes H; Chodosh, James

    2015-02-01

    The aim of this study was to revisit the clinical paradigm attributed to Boston keratoprosthesis recipients presenting with idiopathic vitreous inflammation. A retrospective chart review was performed of keratoprosthesis recipients at Massachusetts Eye and Ear Infirmary, from January 2000 to August 2013, for demographic data, indication(s) for surgery, timing and presentation of vitreous inflammation, and best-corrected visual acuity at baseline, on presentation, and after resolution of vitritis. Twenty-three (23 eyes) of 346 patients developed idiopathic vitreous inflammation after keratoprosthesis implantation. Six of 23 patients presented with signs and symptoms similar to infectious endophthalmitis but were culture negative. The proportion of patients who fit the previous paradigm of sudden painless loss of vision without external signs of infection ("sterile vitritis") at their first presentation with vitritis was only 4 of 23. Vision decline was variable (median, 9 lines on Snellen chart; range, 0-24), as was time to recovery of best vision (median, 8.9 weeks; range, 0.9-36.7). Nine eyes had repeat bouts (43 episodes in 23 patients). Ten of 43 episodes did not recover to baseline vision. Seventeen of 23 eyes with idiopathic vitritis after keratoprosthesis later developed other complications. The current paradigm for idiopathic vitritis after keratoprosthesis implantation includes sudden painless loss of vision with full recovery of vision on treatment with periocular corticosteroids. However, idiopathic vitritis after keratoprosthesis can also mimic infectious endophthalmitis with pain and external signs of inflammation. Visual loss can be gradual. Vision may not recover to baseline despite treatment. Vitritis may be a part of a common pathway of chronic inflammation after keratoprosthesis.

  5. Confirmatory Factor Analysis of the Boston Carpal Tunnel Questionnaire.

    Science.gov (United States)

    Lue, Yi-Jing; Wu, Yuh-Yih; Liu, Ya-Fen; Lin, Gau-Tyan; Lu, Yen-Mou

    2015-12-01

    Carpal tunnel syndrome (CTS) is one of the most common hand problems and a major cause of work disability. The purpose of this study was to use confirmatory factor analysis (CFA) to assess the factor structure of the Boston Carpal Tunnel Questionnaire (BCTQ) in patients with CTS. One hundred and twenty-three patients with CTS were recruited from two hospitals. Each patient completed the functional status scale and the symptom severity scale of the BCTQ. CFA was used to assess the model fit between the data and pre-established theoretical measurement models. CFA showed that all three-factor models were better than the original two-factor model. Among the three-factor models, the simplified model, with 11 items assessing daytime pain, nocturnal numbness/tingling, and hand function was the best, for the model fit the data better than did the other models. Specifically, the Comparative Indices were larger than 0.95 (Tucker-Lewis Index and Comparative Fit Index values), and the Absolute Fit Indices and information-theoretic measures were the smallest. Moreover, all factor loadings were significant and high in magnitude (ranging from 0.66 to 0.99), the composite reliabilities exceeded 0.60 (ranging from 0.78 to 0.94), and the average variance extracted exceeded 0.50 (ranging from 0.61 to 0.89). The simplified model showed the highest reliability and validity, and the factor structure was the simplest/clearest one. The simplified model is recommended for clinical use due to its convenience and precision for assessing the problems of patients with CTS.

  6. The Initial Response to the Boston Marathon Bombing

    Science.gov (United States)

    Gates, Jonathan D.; Arabian, Sandra; Biddinger, Paul; Blansfield, Joe; Burke, Peter; Chung, Sarita; Fischer, Jonathan; Friedman, Franklin; Gervasini, Alice; Goralnick, Eric; Gupta, Alok; Larentzakis, Andreas; McMahon, Maria; Mella, Juan; Michaud, Yvonne; Mooney, David; Rabinovici, Reuven; Sweet, Darlene; Ulrich, Andrew; Velmahos, George; Weber, Cheryl; Yaffe, Michael B.

    2017-01-01

    Objective We discuss the strengths of the medical response to the Boston Marathon bombings that led to the excellent outcomes. Potential shortcomings were recognized, and lessons learned will provide a foundation for further improvements applicable to all institutions. Background Multiple casualty incidents from natural or man-made incidents remain a constant global threat. Adequate preparation and the appropriate alignment of resources with immediate needs remain the key to optimal outcomes. Methods A collaborative effort among Boston’s trauma centers (2 level I adult, 3 combined level I adult/pediatric, 1 freestanding level I pediatric) examined the details and outcomes of the initial response. Each center entered its respective data into a central database (REDCap), and the data were analyzed to determine various prehospital and early in-hospital clinical and logistical parameters that collectively define the citywide medical response to the terrorist attack. Results A total of 281 people were injured, and 127 patients received care at the participating trauma centers on that day. There were 3 (1%) immediate fatalities at the scene and no in-hospital mortality. A majority of the patients admitted (66.6%) suffered lower extremity soft tissue and bony injuries, and 31 had evidence for exsanguinating hemorrhage, with field tourniquets in place in 26 patients. Of the 75 patients admitted, 54 underwent urgent surgical intervention and 12 (22%) underwent amputation of a lower extremity. Conclusions Adequate preparation, rapid logistical response, short transport times, immediate access to operating rooms, methodical multidisciplinary care delivery, and good fortune contributed to excellent outcomes. PMID:25386862

  7. A novel nutrition medicine education model: the Boston University experience.

    Science.gov (United States)

    Lenders, Carine; Gorman, Kathy; Milch, Hannah; Decker, Ashley; Harvey, Nanette; Stanfield, Lorraine; Lim-Miller, Aimee; Salge-Blake, Joan; Judd, Laura; Levine, Sharon

    2013-01-01

    Most deaths in the United States are preventable and related to nutrition. Although physicians are expected to counsel their patients about nutrition-related health conditions, a recent survey reported minimal improvements in nutrition medicine education in US medical schools in the past decade. Starting in 2006, we have developed an educational plan using a novel student-centered model of nutrition medicine education at Boston University School of Medicine that focuses on medical student-mentored extracurricular activities to develop, evaluate, and sustain nutrition medicine education. The medical school uses a team-based approach focusing on case-based learning in the classroom, practice-based learning in the clinical setting, extracurricular activities, and a virtual curriculum to improve medical students' knowledge, attitudes, and practice skills across their 4-y period of training. We have been using objectives from the NIH National Academy Awards guide and tools from the Association of American Medical Colleges to detect new areas of nutrition medicine taught at the medical school. Although we were only able to identify 20.5 h of teaching in the preclerkship years, we observed that most preclerkship nutrition medicine objectives were covered during the course of the 4-y teaching period, and extracurricular activities provided new opportunities for student leadership and partnership with other health professionals. These observations are very encouraging as new assessment tools are being developed. Future plans include further evaluation and dissemination of lessons learned using this model to improve public health wellness with support from academia, government, industry, and foundations.

  8. Avaliação da força de tração em braquetes colados pela técnica indireta com diferentes sistemas de adesão Evaluation of tensile strength of brackets bonded by indirect technique

    Directory of Open Access Journals (Sweden)

    André Tortamano

    2007-06-01

    Full Text Available OBJETIVO: o objetivo do presente estudo foi avaliar a resistência à tração de braquetes ortodônticos colados pela técnica indireta e pela técnica direta convencional. METODOLOGIA: foram utilizados 50 pré-molares humanos íntegros, recém-extraídos por motivos ortodônticos. Esses dentes foram divididos em 5 grupos, nos quais foram colados braquetes ortodônticos metálicos (Abzil-Brasil com as resinas compostas ortodônticas Concise (3M-Unitek-EUA e Transbond XT (3M-Unitek-EUA - utilizadas em ambas as técnicas, direta e indireta - e Transbond Sondhi (3M-Unitek-EUA - desenvolvida exclusivamente para a técnica indireta. O grupo I (controle I foi objeto de colagem direta com Transbond XT; no grupo II (controle II procedeu-se à colagem direta com Concise o grupo III recebeu colagem indireta com Concise; o grupo IV foi submetido à colagem indireta com Transbond XT e no grupo V foi realizada colagem indireta com Transbond Sondhi. Na técnica direta, o braquete foi colado diretamente sobre o esmalte após condicionamento ácido e aplicação de adesivo. Na técnica indireta, os braquetes foram colados primeiramente sobre modelo de gesso e depois transferidos para o dente, com o auxílio de moldeira individualizada. Os corpos-de-prova foram submetidos a testes de tração (Instron 4400 e os resultados foram objeto de testes estatísticos de análise de variância e de Tukey a 1%. RESULTADOS: os grupos III e V revelaram resultados significantemente menores que os dos dois grupos controles. CONCLUSÃO: a força obtida na colagem indireta com a resina Transbond XT não difere da força obtida na colagem direta com as resinas Concise e Transbond XT.AIM: The purpose of this study was to evaluate the bonding strength of brackets for direct and indirect bonding techniques. METHODS: Were used 50 human premolars recently extracted for orthodontic reasons. These teeth were divided in 5 groups and metalic orthodontic brackets (Abzil-Brazil were bonded

  9. In search of the Boston Strangler: genetic evidence from the exhumation of Mary Sullivan.

    Science.gov (United States)

    Foran, David R; Starrs, James E

    2004-01-01

    The Boston Strangler was one of the United States' most notorious serial killers, raping and strangling with decorative ligatures thirteen woman in Boston during the early 1960s. Albert DeSalvo, never a suspect in the slayings, confessed in prison (where he was later murdered) to being the Boston Strangler, and the investigation largely ended. Mary Sullivan was the last victim of the Boston Strangler, found sexually assaulted and strangled in her Boston apartment in 1964. Recently, a team of forensic scientists undertook the exhumation and subsequent scientific analysis of Mary Sullivan's remains, in hope of finding consistencies or inconsistencies between DeSalvo's confessed description of the murder and any evidence left behind. Included in these analyses was extensive DNA testing of all UV fluorescent material associated with the body. The large majority of results were negative, however, fluorescent material located on the underwear and entwined in her pubic hair generated two human mitochondrial DNA sequences. Neither of these matched the victim nor members of the forensic team who worked on the evidence. Most importantly, neither DNA sequence could have originated from Albert DeSalvo.

  10. Cenários da diversidade: variedades de capitalismo e política industrial nos EUA, Alemanha, Espanha, Coreia, Argentina, México e Brasil (1998-2008

    Directory of Open Access Journals (Sweden)

    Ignacio Godinho Delgado

    2010-01-01

    Full Text Available Dans cet article, on examine comment apparaissent aux EUA, en Allemagne, Espagne, Corée, Argentine, au Mexique et Brésil les différents domaines institutionnels analysés par la littérature concernant les variétés de capitalisme (gouvernance entrepreneuriale, rapport entre les entreprises, relations industrielles, relations entreprises-employés, processus de qualification, en y incorporant des aspects comme les rapports Etat patronat ainsi que les modèles d'insertion des économies nationales dans le marché mondial, de façon à reconnaitre les différents cadres institutionnels dans lesquels opèrent les entreprises de ces pays. Ensuite, on présente les principales caractéristiques des politiques industrielles menées par les pays mentionnés, compte-tenu de leur bien-fondé vis-à-vis de ces éléments et du contexte brésilien, de façon à définir les politiques et les changements institutionnels ayant le plus de chance de succès au Brésil quant à l'augmentation de la capacité d'innovation technologique de ses entreprises.

  11. A Comparison of Acute Hemorrhagic Stroke Outcomes in two Populations: The Crete-Boston Study

    Science.gov (United States)

    Zaganas, Ioannis; Halpin, Amy P; Oleinik, Alexandra; Alegakis, Athanasios; Kotzamani, Dimitra; Zafiris, Spiros; Chlapoutaki, Chryssanthi; Tsimoulis, Dimitris; Giannakoudakis, Emmanouil; Chochlidakis, Nikolaos; Ntailiani, Aikaterini; Valatsou, Christina; Papadaki, Efrosini; Vakis, Antonios; Furie, Karen L; Greenberg, Steven M; Plaitakis, Andreas

    2011-01-01

    Background While corticosteroid use in Acute Hemorrhagic Stroke (AHS) is not widely adopted, management with intravenous dexamethasone (IVDxM) has been standard of care at the University Hospital of Heraklion, Crete (UH-Crete) with observed outcomes superior to those reported in literature. To explore this further, we conducted a retrospective, multivariable-adjusted two-center study. Methods We studied 391 AHS cases admitted to UH-Crete between 1/1997 and 7/2010 and compared them with 510 AHS cases admitted to Massachusetts General Hospital, Boston from 1/2003 to 9/2009. Of the Cretan cases, 340 received a tapering scheme of IVDxM, starting with 16–32 mg/day, while the Boston patients were managed without steroids. Results The two cohorts had comparable demographics and stroke severity on admission, although anticoagulation was more frequent in Boston. The in-hospital mortality was significantly lower on Crete (23.8%, n=340) than in Boston (38.0 %, n=510; p<0.001) as was the 30-day mortality (Crete: 25.4%, n=307; Boston: 39.4%, n=510; p<0.001). Exclusion of patients on anticoagulants showed even greater differences (30-day mortality: Crete 20.8%; n=259; Boston 37.0%; n=359; p<0.001). The improved survival on Crete was observed three days after initiation of IVDxM and was pronounced for deep-seated hemorrhages. After adjusting for AHS volume/location, GCS, hypertension, diabetes mellitus, smoking, coronary artery disease and statin, antiplatelet and anticoagulant use, IVDxM treatment was associated with better functional outcomes and significantly lower risk of death at 30-days (odds ratio 0.357; 95% C.I. 0.174–0.732). Conclusions This study suggests that IVDxM improves outcome in AHS and supports a randomized clinical trial using this approach. PMID:22020030

  12. David Sanders. A Divided Poet: Robert Frost, North of Boston, and the Drama of Disappearance.

    Directory of Open Access Journals (Sweden)

    Tatiani G. Rapatzikou

    2012-03-01

    Full Text Available David Sanders in his monograph entitled A Divided Poet: Robert Frost, North of Boston, and the Drama of Disappearance (2011 sheds light on the dilemmas, doubts and personal conflicts Frost confronted while composing his poetic collection North of Boston in which some of his most well-known lyrics, such as “Mending Wall,” “After Apple-Picking,” and “The Wood-Pile,” are contained. This book should be considered alongside a number of other publications either in monograph or essay form that app...

  13. Improved centration of the type 1 Boston Keratoprosthesis in donor carrier tissue

    Directory of Open Access Journals (Sweden)

    Yousuf M Khalifa

    2010-08-01

    Full Text Available Yousuf M Khalifa1, Majid Moshirfar21Flaum Eye Institute, University of Rochester, Rochester, NY, USA; 2Moran Eye Center, University of Utah, Salt Lake City, UT, USAAbstract: The type 1 Boston Keratoprosthesis preparation requires a 3-mm central punch and an 8.5 mm or larger punch in the carrier tissue. These punches are ideally concentric, but we have found difficulty in achieving concentric punches when the larger punch is performed first. We present a modification in the preparation procedure to help minimize centration error.Keywords: Boston Keratoprosthesis, centration error

  14. Treatment of Refractory Keratitis After a Boston Type I Keratoprosthesis With Corneal Collagen Cross-Linking.

    Science.gov (United States)

    Zarei-Ghanavati, Siamak; Irandoost, Fatemeh

    2015-09-01

    To report a patient with refractory keratitis after a Boston type I keratoprosthesis treated with corneal collagen cross-linking (CXL). Case report. A 29-year-old man with a history of chemical burn in the left eye underwent keratoprosthesis implantation. He developed infectious keratitis 4 months after surgery, which did not respond to topical antibiotics. The patient underwent corneal CXL with a shield covering the keratoprosthesis optic. Three weeks after CXL, the infiltration completely resolved. Corneal CXL might be beneficial in the treatment of refractory keratitis in patients with the Boston type I keratoprosthesis.

  15. The Impact of Terrorism on Well-being: Evidence from the Boston Marathon Bombing

    OpenAIRE

    Clark, Andrew E.; Doyle, Orla; Stancanelli, Elena

    2017-01-01

    A growing literature concludes that terrorism impacts the economy, yet less is known about its impact on utility. This paper estimates the impact of the 2013 Boston Marathon Bombing on well-being, by exploiting representative U.S. daily data. Using both a regression discontinuity and an event study design, whereby the 2012 Boston marathon serves as a counterfactual, we find a sharp reduction in well-being, equivalent to a two percentage point rise in annual unemployment. The effect is stronge...

  16. Alcohol advertising on Boston's Massachusetts Bay Transportation Authority transit system: an assessment of youths' and adults' exposure.

    Science.gov (United States)

    Nyborn, Justin A; Wukitsch, Kimberly; Nhean, Siphannay; Siegel, Michael

    2009-11-01

    We investigated the frequency with which alcohol advertisements appeared on Massachusetts Bay Transportation Authority (MBTA) transit lines in Boston, MA, and we calculated adult and youths' exposure to the ads. We measured the nature and extent of alcohol advertisements on 4 Boston transit lines on 2 separate weekdays 1 month apart in June and July of 2008. We calculated weekday ad exposure for all passengers (all ages) and for Boston Public School student passengers (aged 11-18 years). Alcohol ads were viewed an estimated 1,212,960 times across all Boston-area transit passengers during an average weekday, reaching the equivalent of 42.7% of that population. Alcohol ads were viewed an estimated 18,269 times by Boston Public School student transit passengers during an average weekday, reaching the equivalent of 54.1% of that population. Advertisers reached the equivalent of half of all Boston Public School transit passengers aged 11 to 18 years and the equivalent of nearly half of all transit passengers in the Boston area with an alcohol advertisement each day. Because of the high exposure of underage youths to alcohol advertisements, we recommend that the MBTA prohibit alcohol advertising on the Boston transit system.

  17. 75 FR 38411 - Drawbridge Operation Regulations; Chelsea River, Chelsea and East Boston, MA, Event-Road Race

    Science.gov (United States)

    2010-07-02

    ... Boston, MA, Event--Road Race AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from... Chelsea River Revel 5K Road Race. DATES: This deviation is effective from 8 a.m. through 5 p.m. on July 24... Boston, requested a temporary deviation to facilitate a public event, the Chelsea River Revel 5K Road...

  18. "No diversion": a qualitative study of emergency medicine leaders in Boston, MA, and the effects of a statewide diversion ban policy.

    Science.gov (United States)

    O'Keefe, Shannon D; Bibi, Salma; Rubin-Smith, Julia E; Feldman, James

    2014-05-01

    We examine the attitudes of emergency department (ED) key informants about the perceived effects of a statewide ban on ambulance diversion on patients, providers, and working relationships in a large urban emergency medical system. We performed a qualitative study to examine the effects of a diversion ban on Boston area hospitals. Key informants at each site completed semistructured interviews that explored relevant domains pre- and postban. Interviews were deidentified, transcribed, coded, and analyzed with grounded theory for emerging themes. We identified important themes focused on patient safety, quality of care, and relationships before and after implementation of the diversion ban. Nine of 9 eligible sites participated. Eighteen interviews were completed: 7 MD ED directors, 2 MD designees, and 9 registered nurse leaders. Although most participants had negative opinions about diversion, some had considered diversion a useful procedure. Key themes associated with diversion were adverse effects on patient care quality, patient satisfaction, and a source of conflict among ED staff and with emergency medical services (EMS). All key informants described some positive effect of the ban, including those who reported that the ban had no direct effect on their individual hospital. Although the period preceding the ban was reported to be a source of apprehension about its effects, most key informants believed the ban had improved quality of care and relationships between hospital staff and EMS. Key informants considered the diversion ban to have had a favorable effect on emergency medical care in Boston. These results may inform the discussion in other states considering a diversion ban. Copyright © 2013 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.

  19. Earth Sciences at Boston University: Reorientation and Renewal

    Science.gov (United States)

    Murray, R. W.; Simpson, C.

    2003-12-01

    Beginning in 1994 with the renaming of its Department of Geology as the Department of Earth Sciences, Boston University has invested much effort into developing a modern, energetic department that excels in its dual research and teaching mission. These changes required strong leadership at the departmental and senior administrative level, but they have resulted in a moderately sized program (9.5 full time faculty) that is competing with "Top Ten" institutions for graduate students and faculty, and which is also placing its undergraduates in the leading graduate programs. Most of the revitalization was achieved over a 5-year period in which across the board changes occurred in our undergraduate curriculum and during which we recruited junior and mid-level faculty on the basis of their scholarly abilities and for their belief in the culture of our new mission and program. The undergraduate curriculum, which had been oriented towards traditional geologic offerings, was greatly increased in rigor (requiring a full year each of calculus, physics, and chemistry) and redesigned to expand flexibility in the broad field of earth sciences. During the evolution of the curriculum, it was extremely important not to confuse "tradition" with "rigor". Undergraduates became more critically involved with our research mission through senior theses, a formal Undergraduate Research Opportunities program, and by work-study participation in the laboratories. By making the program more challenging, over the period of 3 years we doubled the number of majors and minors and increased the average GPA by 0.5 units. Now, after 8 years, we have nearly tripled our overall number of students, with further improvements in quality and intellectual diversity. The opportunity to replace departing senior faculty was achieved through effectively arguing to the central administration that modern earth sciences are an essential component of any leading institution of higher education. By persuading the

  20. Designing a Case Study from the Popular Culture Text "Boston Public"

    Science.gov (United States)

    Trier, James

    2010-01-01

    In this article, the author begins with a selective review of the case study literature that reveals that most case studies are based on "real," "actual," and "true" experiences. Next, he describes a case study that he designed from a fictional source--i.e., from an episode of the television series "Boston Public." Then, he explains what happened…

  1. Effectiveness of automated external defibrillators in high schools in greater Boston.

    Science.gov (United States)

    England, Hannah; Hoffman, Caitlin; Hodgman, Thomas; Singh, Sushil; Homoud, Munther; Weinstock, Jonathan; Link, Mark; Estes, N A Mark

    2005-06-15

    A program using a strategy of donating a single automatic external defibrillator to 35 schools in the Boston area resulted in compliance with American Heart Association guidelines on automatic external defibrillator placement and training and 2 successful resuscitations from sudden cardiac arrest. Participating schools indicated a high degree of satisfaction with the program.

  2. Slope Instability of the Earthen Levee in Boston, UK: Numerical Simulation and Sensor Data Analysis

    NARCIS (Netherlands)

    Melnikova, N.B.; Jordan, D.; Krzhizhanovskaya, V.V.; Sloot, P.M.A.

    2014-01-01

    The paper presents a slope stability analysis for a heterogeneous earthen levee in Boston, UK, which is prone to occasional slope failures under tidal loads. Dynamic behavior of the levee under tidal fluctuations was simulated using a finite element model of variably saturated linear elastic

  3. How Important Are Classroom Peer Effects? Evidence from Boston's METCO Program. Working Paper Series.

    Science.gov (United States)

    Angrist, Joshua, D.; Lang, Kevin

    This paper studies the impact of the Metropolitan Council for Educational Opportunities (METCO), a desegregation program that sends mostly black students out of the Boston public school district to attend schools in more affluent suburban districts. It examines METCO's impact on the test scores of third, fifth, and seventh graders in a large…

  4. Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study

    Science.gov (United States)

    The objective of this study is to examine a functional variant (rs6265) in the BDNF gene interacting with dietary intake modulate obesity traits in the Boston Puerto Rican Health Study population. BDNF rs6265 was genotyped in 1147 Puerto Ricans (aged 45-75 years), and examined for association with o...

  5. Gun Carrying by High School Students in Boston, MA: Does Overestimation of Peer Gun Carrying Matter?

    Science.gov (United States)

    Hemenway, David; Vriniotis, Mary; Johnson, Renee M.; Miller, Matthew; Azrael, Deborah

    2011-01-01

    This paper investigates: (1) whether high school students overestimate gun carrying by their peers, and (2) whether those students who overestimate peer gun carrying are more likely to carry firearms. Data come from a randomly sampled survey conducted in 2008 of over 1700 high school students in Boston, MA. Over 5% of students reported carrying a…

  6. Boston University: Sustainability Revolving Loan Fund. Green Revolving Funds in Action: Case Study Series

    Science.gov (United States)

    Flynn, Emily

    2011-01-01

    Boston University's (BU) Sustainability Revolving Loan Fund was created in 2008 through an allocation of $1 million from the university's administrative budget. The fund is administered by the Vice President of Operations. Potential projects are identified by the university's Director of Energy Administration and Operations along with the…

  7. Outcomes with the Boston Type 1 Keratoprosthesis at Instituto de Microcirugía Ocular IMO.

    Science.gov (United States)

    Güell, Jose L; Arcos, Edilio; Gris, Oscar; Aristizabal, Diego; Pacheco, Miguel; Sanchez, Claudia L; Manero, Felicidad

    2011-07-01

    To report the outcomes on the Boston Type 1 Keratoprosthesis at our institution. Retrospective analysis case series. We analyzed 54 eyes of 53 patients who previously underwent Boston Type 1 Keratoprosthesis surgery at our institution from July 2006 to March 2011. Preoperative and postoperative parameters were collected and analyzed. Visual acuity and keratoprosthesis stability. Common preoperative diagnoses were penetrating keratoplasty failure in 49 eyes (90.7%), chronic keratitis in 2 eyes (3.7%), ocular cicatricial pemphigoid in 1 eye (1.85%), Stevens Johnson syndrome in 1 eye (1.85%) and corneal vascularization in 1 eye (1.85%). Additionally, 40 eyes (74%) had preoperative glaucoma, and an Ahmed valve was implanted in 55% of them. Preoperative BCVA ranged from 20/200 to light perception. At an average follow-up of 20.15 months ± 12.7 (range, 1-56), postoperative vision improved to ⩾20/200 in 18 eyes (33.3%) and ⩾20/50 in 4 eyes (7.4%). The graft retention was 96%. The Boston Type 1 keratoprosthesis is a valid option for high-risk patients. The design improvements in the Boston keratoprosthesis, as well as the daily implementation of the therapeutic methods, have notably diminished occurrence of the most serious complications, such as corneal necrosis and endophthalmitis. As such, glaucoma and its subsequent complications now stand as the most prevalent prognostic factor in the long term.

  8. Boston type 1 keratoprosthesis: the New York Eye and Ear experience.

    Science.gov (United States)

    Patel, A P; Wu, E I; Ritterband, D C; Seedor, J A

    2012-03-01

    The Boston keratoprosthesis has had variable success rates in the past. However, significant modifications to design and management have recently led to successful outcomes. This study was undertaken to evaluate the outcomes of the Boston type 1 keratoprosthesis at our institution. A retrospective chart review was performed of all Boston type 1 keratoprosthesis procedures conducted at a single practice at the New York Eye and Ear Infirmary from December 2006 to August 2010. Outcome measures included visual acuity, retention rates, and complications. In all, 58 eyes of 51 patients who received a Boston type 1 keratoprosthesis were included. The most common indication for the keratoprosthesis was failed penetrating keratoplasty (PK) (81.0%; mean 2.4±1.3 PKs per eye). Glaucoma was the most common comorbidity (75.9%). Pre-operative best corrected visual acuity (BCVA) was keratoprosthesis provides visual recovery for eyes with multiple PK failures or with poor prognosis for primary PK, showing excellent retention rates. However, there is a trend towards a decline in visual acuity with time and the development of late complications, highlighting a need for longer-term studies.

  9. Improved centration of the type 1 Boston Keratoprosthesis in donor carrier tissue

    Science.gov (United States)

    Khalifa, Yousuf M; Moshirfar, Majid

    2010-01-01

    The type 1 Boston Keratoprosthesis preparation requires a 3-mm central punch and an 8.5 mm or larger punch in the carrier tissue. These punches are ideally concentric, but we have found difficulty in achieving concentric punches when the larger punch is performed first. We present a modification in the preparation procedure to help minimize centration error. PMID:20823936

  10. Fire history of oak­pine forests in the Lower Boston Mountains, Arkansas, USA

    Science.gov (United States)

    R.P. Guyette; Martin A. Spetich

    2003-01-01

    Perspective on present day issues associated with wildland fire can be gained by studying the long-term interactions among humans, landscape, and fire. Fire frequency and extent over the last 320 years document these interactions north of the Arkansas River on the southern edge of the Lower Boston Mountains. Dendrochronological methods were used to construct three fire...

  11. The Boston Massacre: A Paradigm for Developing Thinking and Writing Skills.

    Science.gov (United States)

    Ladenburg, Thomas; Tegnell, Geoffrey

    1986-01-01

    Eighth graders participate in a mock trial of the Boston Massacre. Throughout the trial, students are given writing assignments based on Bloom's forms of thinking operations. For example, they write argumentative paragraphs as verdicts, write essays comparing and contrasting issues, and agree on criteria for evaluating the actions of both sides.…

  12. 33 CFR 165.T01-0542 - Safety Zones: Neptune Deepwater Port, Atlantic Ocean, Boston, MA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zones: Neptune Deepwater... Guard District § 165.T01-0542 Safety Zones: Neptune Deepwater Port, Atlantic Ocean, Boston, MA. (a...-meter radius of each of the two STL buoys of the Neptune Deepwater Port, marked on the surface of the...

  13. Development of a Short Form of the Boston Naming Test for Individuals with Aphasia

    Science.gov (United States)

    del Toro, Christina M.; Bislick, Lauren P.; Comer, Matthew; Velozo, Craig; Romero, Sergio; Rothi, Leslie J. Gonzalez; Kendall, Diane L.

    2011-01-01

    Purpose: The purpose of this study was to develop a short form of the Boston Naming Test (BNT; Kaplan, Goodglass, & Weintraub, 2001) for individuals with aphasia and compare it with 2 existing short forms originally analyzed with responses from people with dementia and neurologically healthy adults. Method: Development of the new BNT-Aphasia Short…

  14. The Past Is Never Dead—Measles Epidemic, Boston, Massachusetts, 1713

    Centers for Disease Control (CDC) Podcasts

    2015-08-04

    Dr. David Morens reads excerpts from his essay about Cotton Mather’s diary, which details the experience and tragedy of the measles outbreak in Boston, Massachusetts in 1713.  Created: 8/4/2015 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 8/4/2015.

  15. Immigration, Suicidal Ideation and Deliberate Self-Injury in the Boston Youth Survey 2006

    Science.gov (United States)

    Borges, Guilherme; Azrael, Deborah; Almeida, Joanna; Johnson, Renee M.; Molnar, Beth E.; Hemenway, David; Miller, Matthew

    2011-01-01

    The prevalence and immigration-related correlates of deliberate self-injury (DSI) and suicidal ideation (SI) were estimated in a sample of Boston public high school students in 2006. Compared with U.S.-born youth, immigrant youth were not at increased risk for DSI or SI, even if they had experienced discrimination due to their ancestry. By…

  16. Cumulative exposure to prior collective trauma and acute stress responses to the Boston marathon bombings.

    Science.gov (United States)

    Garfin, Dana Rose; Holman, E Alison; Silver, Roxane Cohen

    2015-06-01

    The role of repeated exposure to collective trauma in explaining response to subsequent community-wide trauma is poorly understood. We examined the relationship between acute stress response to the 2013 Boston Marathon bombings and prior direct and indirect media-based exposure to three collective traumatic events: the September 11, 2001 (9/11) terrorist attacks, Superstorm Sandy, and the Sandy Hook Elementary School shooting. Representative samples of residents of metropolitan Boston (n = 846) and New York City (n = 941) completed Internet-based surveys shortly after the Boston Marathon bombings. Cumulative direct exposure and indirect exposure to prior community trauma and acute stress symptoms were assessed. Acute stress levels did not differ between Boston and New York metropolitan residents. Cumulative direct and indirect, live-media-based exposure to 9/11, Superstorm Sandy, and the Sandy Hook shooting were positively associated with acute stress responses in the covariate-adjusted model. People who experience multiple community-based traumas may be sensitized to the negative impact of subsequent events, especially in communities previously exposed to similar disasters. © The Author(s) 2015.

  17. Controlling Violent Offenders Released to the Community: An Evaluation of the Boston Reentry Initiative

    Science.gov (United States)

    Braga, Anthony A.; Piehl, Anne M.; Hureau, David

    2009-01-01

    Despite the high level of funding and policy interest in prisoner reentry, there is still little rigorous scientific evidence to guide jurisdictions in developing reentry programs to enhance public safety, particularly for managing those who pose the greatest safety risks. The Boston Reentry Initiative (BRI) is an interagency initiative to help…

  18. 77 FR 44301 - Self-Regulatory Organizations; Boston Stock Exchange Clearing Corporation; Notice of Filing of...

    Science.gov (United States)

    2012-07-27

    ... of a broker or dealer, and such services relate to the director's, officer's, or employee's... COMMISSION Self-Regulatory Organizations; Boston Stock Exchange Clearing Corporation; Notice of Filing of...). \\2\\ 17 CFR 240.19b-4. I. Self-Regulatory Organization's Statement of the Terms of the Substance of...

  19. Variations in Atmospheric CO2 Mixing Ratios across a Boston, MA Urban to Rural Gradient

    Directory of Open Access Journals (Sweden)

    Brittain M. Briber

    2013-07-01

    Full Text Available Urban areas are directly or indirectly responsible for the majority of anthropogenic CO2 emissions. In this study, we characterize observed atmospheric CO2 mixing ratios and estimated CO2 fluxes at three sites across an urban-to-rural gradient in Boston, MA, USA. CO2 is a well-mixed greenhouse gas, but we found significant differences across this gradient in how, where, and when it was exchanged. Total anthropogenic emissions were estimated from an emissions inventory and ranged from 1.5 to 37.3 mg·C·ha−1·yr−1 between rural Harvard Forest and urban Boston. Despite this large increase in anthropogenic emissions, the mean annual difference in atmospheric CO2 between sites was approximately 5% (20.6 ± 0.4 ppm. The influence of vegetation was also visible across the gradient. Green-up occurred near day of year 126, 136, and 141 in Boston, Worcester and Harvard Forest, respectively, highlighting differences in growing season length. In Boston, gross primary production—estimated by scaling productivity by canopy cover—was ~75% lower than at Harvard Forest, yet still constituted a significant local flux of 3.8 mg·C·ha−1·yr−1. In order to reduce greenhouse gas emissions, we must improve our understanding of the space-time variations and underlying drivers of urban carbon fluxes.

  20. Entre livros e televisão: ambiguidades históricas em Fahrenheit 451

    OpenAIRE

    Rangel, Luiz Aloysio Mattos

    2012-01-01

    O presente artigo trata de ambiguidades históricas a partirda análise da obra de ficção científica Fahrenheit 451 (1953), do escritor norte-americano Ray Bradbury. Tem por base a constatação de que o período do qual a obra é um produto é abordado pela historiografia sob duas diretrizes principais. Os EUA dos anos 1950 são notadamente marcados pelo contexto da Guerra Fria e as implicações de um mundo bipolarizado em conflito pela imposição de ideologias incompatíveis, mas também é um período d...

  1. Prevalence of early childhood caries among very young urban Boston children compared with US children.

    Science.gov (United States)

    Nunn, Martha E; Dietrich, Thomas; Singh, Harpreet K; Henshaw, Michelle M; Kressin, Nancy R

    2009-01-01

    The aims of this study were to compare prevalence of early childhood caries (ECC) in 1- to 3-year-old children seeing primary-care pediatricians at two urban medical centers in Boston to the prevalence of ECC in similarly aged US children surveyed as part of the Third National Health and Nutrition Examination Survey (NHANES III) and to assess risk factors for ECC among this cohort of children compared with risk factors among similarly aged US children. Characteristics of 787 1- to 3-year-old children from two urban Boston medical centers were compared with those of 3,644 similarly aged US children surveyed as part of NHANES III. Demographic and social characteristics and ECC prevalence by putative risk factors were compared. A multiple logistic regression model was fit to assess putative risk factors and difference between groups simultaneously. Race, age, previous dental visit, parents' education, and household income were significantly associated with ECC prevalence. Parents' place of birth was a significant effect modifier with lower ECC among Boston children of immigrants than among US children of immigrants. Lower ECC prevalence among urban Boston children of immigrant parents compared with US children of immigrant parents may reflect changing immigrant composition in the United States since NHANES III or a different immigrant composition in the Boston area compared with the United States. This finding reinforces the need for further research of immigrants in order to understand cultural practices that may affect oral health. Finally, low ECC prevalence among very young children reinforces the importance of early intervention in reducing ECC.

  2. Has Boston's 2011 cigar packaging and pricing regulation reduced availability of single-flavoured cigars popular with youth?

    Science.gov (United States)

    Li, Wenjun; Gouveia, Tami; Sbarra, Cheryl; Harding, Nikysha; Kane, Kevin; Hayes, Rashelle; Reid, Margaret

    2017-03-01

    We evaluated retailer compliance with a cigar packaging and pricing regulation in Boston, Massachusetts, enacted in February 2012, and the regulation's impact on availability of single cigars. Grape-flavoured Dutch Masters (DM) single-packaged cigars were examined as market indicator. At quarterly intervals from October 2011 to December 2014, availability and price of DM single cigars were observed through professional inspector visits to tobacco retailers in Boston (n=2232) and 10 comparison cities (n=3400). Differences in price and availability were examined between Boston and the comparison cities and across Boston neighbourhoods. The mean price of DM single cigars sold in Boston increased from under $1.50 in 2011 to above $2.50 in 2014, consistent with regulation requirements. Rates of retailer compliance reached 100% within 15 months postpolicy enactment based on observed price, and 97% at 30 months postenactment based on final sale prices. There was a 34.5% net decrease in the percentage of Boston retailers selling single cigars from 2011 to 2014. The number of Boston neighbourhoods with 3 or more retailers selling single cigars per 100 youth residents decreased from 12 in 2011 to 3 in 2014. No change in price or per cent of retailers selling single cigars was observed in the comparison cities in the same period. Retailers throughout Boston are in compliance with the regulation. The regulation has been effective in reducing levels and disparities in availability of flavoured single cigars popular with youth across Boston neighbourhoods, regardless of socioeconomic status and racial/ethnic composition. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  3. Narrativa sensacionalista e ficção especulativa sobre o aquecimento global: Catarse, alerta, realidade e ficção em "O Dia Depois de Amanhã"

    Directory of Open Access Journals (Sweden)

    Carolina Maria Zoccoli Carneiro

    2010-06-01

    Full Text Available

    Tomando como objeto de análise o filme <em>O Dia Depois de Amanhãem> (EUA, 2004, este artigo tem como objetivo discutir como uma abordagem sensacionalista sobre questões ambientais, como o aquecimento global, pode propor uma mistura entre realidade - embasada em fatos científicos – e ficção, atraindo o espectador por meio de suas sensações. Para isto, trabalhamos sobre o conceito de sensacionalismo e suas origens, além do potencial atrativo do ficcional e da fantasia.

  4. Reiterando o pacto: história, teologias políticas cristãs e a religião civil americana em uma era de multiculturalismo e império

    Directory of Open Access Journals (Sweden)

    Bruno Reinhardt

    2011-01-01

    Full Text Available Há 40 anos, em plena Guerra Fria, Robert Bellah concluiu seu célebre artigo sobre a religião civil americana com a seguinte pergunta: como conceber a aplicabilidade legítima dos valores-chave que suportam o imaginário nacional americano para além dos confins territoriais do seu Estado-nação? O presente artigo quer revisitar esta questão criticamente à luz de incursões regulatórias recentes dos EUA sobre o campo da liberdade religiosa no globo. Primeiramente, reviso a história da relação entre secularismo, identidade nacional e cristianismo nos EUA. A seguir, analiso as articulações político-religiosas que dão origem ao International Freedom of Religion Act (IRFA, em 1998. Por fim, tento destacar como este exercício pode fornecer contribuições mais gerais para o estudo da relação entre religião, nacionalismo e poder secular na contemporaeidade, com ênfase na relação entre estes e o princípio de soberania do estado de direito.

  5. The Customer is Always Right, Right?A Look at How Yelp Has Taken Hold of the Boston Restaurant Industry

    Directory of Open Access Journals (Sweden)

    Rachel DeSimone

    2015-05-01

    Full Text Available The Internet and mobile availability has changed the restaurant review game. Local Boston chefs and restaurant managers reflect on the pros and cons of such outlets, like Yelp, on their businesses and menus.

  6. EASE-Grid 2.0 Land Cover Classifications Derived from Boston University MODIS/Terra Land Cover Data

    Data.gov (United States)

    National Aeronautics and Space Administration — These data provide land cover classifications derived from the Boston University MOD12Q1 V004 MODIS/Terra 1 km Land Cover Product (Friedl et al. 2002). The data are...

  7. TODAY: EPA Administrator McCarthy in Boston with Canada and Mexico for Commission on Environmental Cooperation

    Science.gov (United States)

    BOSTON, MA; WASHINGTON - On Tuesday and Wednesday, U.S. Environmental Protection Agency Administrator Gina McCarthy will host Mexican Environment Deputy Secretary Dr. Rodolfo Lacy Tamayo representing Secretary Juan José Guerra Abud and Canadian E

  8. Boston Type I Keratoprosthesis Implantation Following Autologous Submandibular Gland Transplantation for End Stage Ocular Surface Disorders.

    Science.gov (United States)

    Gu, Jianjun; Zhai, Jiajie; Liao, Guiqing; Chen, Jiaqi

    2016-10-11

    To describe the results of Boston keratoprosthesis implantation in a patient with Stevens-Johnson syndrome following autologous submandibular gland transplantation. Observational case report. We report the case of a man diagnosed with Stevens-Johnson syndrome. Autologous submandibular gland transplantation was performed in the right eye in 2008 to ameliorate tear film deficiency. Due to the improvement in the microenvironment of the ocular surface, Boston keratoprosthesis implantation was performed in the right eye in 2011. He maintained a VA of 20/100 for 12 months. At the last follow-up visit (54 months), his VA had declined to finger count level due to de novo glaucoma, which was treated with glaucoma drainage device implantation, cyclophotocoagulation and topical anti-glaucoma medications. The procedures described provide patients with end-stage ocular surface disease an option to lessen the severity of keratoconjunctivitis sicca and to regain their VA.

  9. International Outcomes of the Boston Type I Keratoprosthesis in Stevens-Johnson Syndrome.

    Science.gov (United States)

    Alexander, Jamie K; Basak, Samar K; Padilla, Ma Dominga B; Yu, Fei; Aldave, Anthony J

    2015-11-01

    To determine the factors influencing outcomes of Boston type I keratoprosthesis implantation in Stevens-Johnson syndrome (SJS) and to compare the results with those of individuals without SJS. This is a multicenter, retrospective, comparative consecutive case series of patients undergoing keratoprosthesis implantation in Los Angeles, Kolkata, and Manila. Statistical analysis was performed to identify significant differences in visual acuity, complications, and retention between SJS and non-SJS populations. A total of 234 keratoprosthesis procedures were performed in 209 eyes, including 40 performed in 27 eyes of 26 patients with SJS. Procedures in patients with SJS were more frequently performed as repeat keratoprostheses (33% vs. 8%, P keratoprosthesis (82% vs. 89%, P = 0.34). The Boston type I keratoprosthesis is an effective means to restore vision in individuals with SJS. Although retention failure and several postoperative complications are more common in SJS, sight-threatening complications such as endophthalmitis and retinal detachment are not.

  10. Twitter as a Sentinel in Emergency Situations: Lessons from the Boston Marathon Explosions

    Science.gov (United States)

    Cassa, Christopher A.; Chunara, Rumi; Mandl, Kenneth; Brownstein, John S

    2013-01-01

    Immediately following the Boston Marathon attacks, individuals near the scene posted a deluge of data to social media sites. Previous work has shown that these data can be leveraged to provide rapid insight during natural disasters, disease outbreaks and ongoing conflicts that can assist in the public health and medical response. Here, we examine and discuss the social media messages posted immediately after and around the Boston Marathon bombings, and find that specific keywords appear frequently prior to official public safety and news media reports. Individuals immediately adjacent to the explosions posted messages within minutes via Twitter which identify the location and specifics of events, demonstrating a role for social media in the early recognition and characterization of emergency events. *Christopher Cassa and Rumi Chunara contributed equally to this work. PMID:23852273

  11. O Uso do Laser em Cirurgia Vascular / The Use of Laser in Vascular Surgery

    Directory of Open Access Journals (Sweden)

    Melissa Andreia de Moraes Silva

    2011-09-01

    Full Text Available Princípios do laser Uma das maiores revoluções tecnológicas da humanidade foi postulada no início do século XX: a teoria do mecanismo de emissão estimulada. Albert Einstein, em 1905, com o auxílio dos postulados de Max Planck, elaborou o conceito dos quanta (fótons na formação da luz (Figura 1. Em 1953, Charles Hard Townes e colaboradores produziram o primeiro dispositivo capaz de produzir microondas ao invés de luz visível, a maser (microwave amplification through stimulated emission of radiation. Anos após o maser, este dispositivo foi adaptado para emitir luz visível, então batizado de laser. Theodore Harold Maiman foi o primeiro a construir, em 1960, um equipamento gerador de laser. Composto de cristal de rubi, foi operado pela primeira vez neste mesmo ano em Malibu (Califórnia, EUA.

  12. Caregiver-reports of Internet Exposure and Posttraumatic Stress Among Boston-Area Youth Following the 2013 Marathon Bombing

    OpenAIRE

    Comer, Jonathan S.; DeSerisy, Mariah; Green, Jennifer Greif

    2016-01-01

    Although practitioners and researchers have considered children’s television-based terrorism exposure, Internet-based exposure has not been sufficiently examined. We examined the scope and correlates of children’s Internet-based exposure following the Boston Marathon bombing among Boston-area youth (N=460; 4–19 years), and the potential moderating role of age. Further exploratory analyses examined patterns of caregiver attempts to regulate child Internet exposure. Caregivers reported on child...

  13. Local Spatial Clustering in Youths Use of Tobacco, Alcohol and Marijuana in Boston, Massachusetts, USA

    Science.gov (United States)

    Duncan, Dustin T.; Rienti, Michael; Kulldorff, Martin; Aldstadt, Jared; Castro, Marcia C.; Frounfelker, Rochelle; Williams, James H.; Sorensen, Glorian; Johnson, Renee M.; Hemenway, David; Williams, David R.

    2016-01-01

    Background Understanding geographic variation in youth drug use is important for both identifying etiologic factors and planning prevention interventions. However, little research has examined spatial clustering of drug use among youth using rigorous statistical methods. Objectives The purpose of this study is to examine spatial clustering of youth use of tobacco, alcohol, and marijuana. Methods Responses on tobacco, alcohol, and marijuana use from 1,292 high school students ages 13-19 who provided complete residential addresses were drawn from the 2008 Boston Youth Survey Geospatial Dataset. Response options on past month use included “none”, “1-2”, “3-9”, and “10 or more”. The response rate for each substance was approximately 94%. Spatial clustering of youth drug use was assessed using the spatial Bernoulli model in the SatScan™ software package. Results Approximately 12%, 36%, and 18% of youth reported any past-month use of tobacco, alcohol, and/or marijuana, respectively. Two clusters of elevated past tobacco use among Boston youths were generated, one of which was statistically significant. This cluster, located in the South Boston neighborhood, had a relative risk of 5.37 with a p-value of 0.00014. There was no significant localized spatial clustering in youth past alcohol or marijuana use in either the unadjusted or adjusted models. Conclusion Significant spatial clustering in youth tobacco use was found, and this type of research can be used for local targeting of drug abuse prevention interventions. Finding a significant cluster in the South Boston neighborhood provides reason for further investigation into neighborhood characteristics that may shape adolescents’ substance use behaviors. Future research should evaluate the underlying reasons behind spatial clustering of youth substance use. PMID:27096932

  14. Ceratoprótese de Boston tipo I: Revisão

    OpenAIRE

    Fernanda Pedreira Magalhães; Luciene Barbosa de Sousa; Lauro Augusto de Oliveira

    2012-01-01

    Regardless of significant progress in the field of corneal transplantation to treat corneal opacification, some cases of corneal blindness still present a poor prognosis for conventional penetrating keratoplasty. In patients with repeated graft failure and/or with severe ocular surface disease, the Boston type I keratoprosthesis (type I BKPro) has become a viable option. Modifications in its design and postoperative management have improved the long-term outcomes of visual acuity, retention, ...

  15. Boston type 1 keratoprosthesis from patient selection through postoperative management: a review for the keratoprosthetic surgeon

    Science.gov (United States)

    Williamson, Samantha L; Cortina, M Soledad

    2016-01-01

    For the anterior segment surgeon, the implantation of Boston type 1 keratoprosthesis is a multistep process that begins with careful patient selection. Success depends on thorough preoperative evaluation, detailed surgical planning, and frequent postoperative follow-up. New practice patterns have emerged for each of these phases as the international experience with keratoprosthesis grows. This review details special considerations that can improve outcomes and also allow surgeons to consider its use in challenging patient populations at each step. PMID:27041986

  16. Boston Type 1 Keratoprosthesis for Gelatinous Drop-Like Corneal Dystrophy.

    Science.gov (United States)

    Lekhanont, Kaevalin; Jongkhajornpong, Passara; Chuephanich, Pichaya; Inatomi, Tsutomu; Kinoshita, Shigeru

    2016-06-01

    To report the outcomes of Boston type 1 keratoprosthesis in the management of advanced gelatinous drop-like corneal dystrophy (GDLD). A retrospective, noncomparative, interventional case series was conducted at Ramathibodi Hospital, Bangkok, Thailand. Four eyes of three siblings with molecularly and histologically confirmed GDLD from a Thai family underwent an uneventful Boston type 1 keratoprosthesis implantation for visual rehabilitation. Clinical data were obtained from a review of the medical records. Visual acuity, device retention, and postoperative complications were the main outcome measures. The follow-up ranged from 8 to 96 months. One eye received keratoprosthesis surgery as a primary penetrating procedure. The other three eyes had the surgery as a secondary procedure after graft failure. Best-corrected visual acuity was favorably improved from counting fingers to 20/25 in two eyes, from hand movement to 20/20 in one eye, and from hand movement to counting fingers at 2 feet in one eye caused by severe amblyopia. The improved vision was maintained for 8 months to 6.2 years after surgery. Postoperative complications included disease recurrence in the donor graft (N = 3), manageable retroprosthetic membrane (N = 3), intraocular pressure elevation responded to antiglaucoma drugs (N = 2), and Pseudomonas keratitis with severe corneal melting requiring device removal (N = 1). All of our patients failed to have a comfortably well-fitting contact lens after surgery. Boston type 1 keratoprosthesis could be considered as a reasonable option in the management of advanced GDLD. However, patients remain at risk for sight-threatening postoperative complications as long as the keratoprosthesis is retained. The use of Boston keratoprosthesis implantation needed to be individualized on a case-by-case basis.

  17. Boston type 1 keratoprosthesis from patient selection through postoperative management: a review for the keratoprosthetic surgeon.

    Science.gov (United States)

    Williamson, Samantha L; Cortina, M Soledad

    2016-01-01

    For the anterior segment surgeon, the implantation of Boston type 1 keratoprosthesis is a multistep process that begins with careful patient selection. Success depends on thorough preoperative evaluation, detailed surgical planning, and frequent postoperative follow-up. New practice patterns have emerged for each of these phases as the international experience with keratoprosthesis grows. This review details special considerations that can improve outcomes and also allow surgeons to consider its use in challenging patient populations at each step.

  18. Characteristics and vitreoretinal management of retinal detachment in eyes with Boston keratoprosthesis.

    Science.gov (United States)

    Petrou, Petros; Banerjee, Philip J; Wilkins, Mark R; Singh, Mandeep; Eastlake, Karen; Limb, G Astrid; Charteris, David G

    2017-05-01

    To review the incidence and features of vitreoretinal complications of a permanent Boston keratoprosthesis and to report the use and outcomes of 23-gauge vitrectomy to manage vitreoretinal pathology. Retrospective non-comparative, interventional case series. 27 eyes of 27 patients managed with a Boston keratoprosthesis at Moorfields Eye Hospital over a 3-year period. All eyes that underwent pars plana vitrectomy (PPV) and had at least 6 months follow-up were analysed with a specific focus on the anatomical and histological characteristics of retinal detachment and outcomes of surgery. Anatomical success and characteristics of retinal detachment over the follow-up period. 27 patients underwent Boston keratoprosthesis implantation over the study period. Of these, six (22%) required PPV for retinal detachment which demonstrated a specific pattern of serous elevation with subsequent severe anterior proliferative vitreoretinopathy (PVR). The mean follow-up period was 9 months (range 6-14 months). At final follow-up, visual acuity ranged from perception of light to 6/18, and five of six cases had attached retinae under the silicone oil. Histological analysis of a subretinal membrane demonstrated a predominantly glial/retinal pigment epithelium fibrocellular tissue, consistent with PVR. The study showed that retinal detachment complicated by PVR, as demonstrated by the clinical and histological characteristics of this condition, is common in patients undergoing Boston keratoprosthesis. We also showed that 23-gauge vitrectomy can be effectively performed in patients with a permanent prosthesis. Visual acuity often remains poor, despite successful anatomical results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  19. The Boston keratoprosthesis type II: the Massachusetts Eye and Ear Infirmary experience.

    Science.gov (United States)

    Pujari, Siddharth; Siddique, Sana S; Dohlman, Claes H; Chodosh, James

    2011-12-01

    To report the long-term outcomes of Boston keratoprosthesis type II implantation in the management of severe ocular surface disease and corneal blindness through a retrospective interventional case series. This retrospective review included medical records of patients who underwent Boston keratoprosthesis type II implantation at the Massachusetts Eye and Ear Infirmary from January 1, 2000 through December 31, 2009. The main outcome measures analyzed were visual acuity, keratoprosthesis retention, and postoperative complications. A total of 29 eyes of 26 patients received a Boston keratoprosthesis type II during the study period. Patients undergoing operation had corneal blindness because of mucous membrane pemphigoid (51.7%), Stevens-Johnson syndrome/toxic epidermal necrolysis (41.4%), or other ocular surface disease (6.9%). Visual acuity after surgery improved to 20/200 or better in 23 eyes (79.3%) and to 20/30 or better in 10 eyes (34.5%). In patients with at least 1 year of follow-up (n = 21), visual acuity of 20/200 or better was maintained in 12 eyes (57.1%). Of 13 eyes followed-up for more than 5 years, 6 eyes (46.2%) had visual acuity of 20/200 or better at the last follow-up examination. Eyes that did not improve to 20/200 or lost vision during the follow-up had end-stage glaucoma, previous retinal detachment, or age-related macular degeneration. Of the total of 29 eyes, 17 devices (58.6%) were retained without extrusion or replacement during a total follow-up time of 107.9 person-years. The Boston keratoprosthesis type II is a viable option for corneal blindness from severe autoimmune ocular surface diseases.

  20. Lessons in Leadership From 3 Nurse Practitioners at the Boston Health Care for the Homeless Program.

    Science.gov (United States)

    Thomas, Melinda

    Nurse practitioners play an integral role in the care of patients in underserved areas. At the Boston Health Care for the Homeless Program, many nurses have been promoted into leadership positions. Three nurse practitioners were asked to discuss their career paths, talk about leadership in the context of their career trajectory, and do so while considering how their training and clinical work prepared them to take on leadership roles.

  1. Modeling air pollution in the Washington, D.C., to Boston megalopolis.

    Science.gov (United States)

    Slade, D H

    1967-09-15

    Simplified meteorological models and pollutant source configurations were used to demonstrate the types of pollutant patterns that might be encountered in the Washington, D.C.-Boston megalopolitan corridor. A semirealistic source distribution and source intensity of carbon dioxide were used in this demonstration. The results of the computations suggest that local increases in quantities of pollutants may at times require regional rather than local source consideration.

  2. Adjustment among area youth after the Boston Marathon bombing and subsequent manhunt.

    Science.gov (United States)

    Comer, Jonathan S; Dantowitz, Annie; Chou, Tommy; Edson, Aubrey L; Elkins, R Meredith; Kerns, Caroline; Brown, Bonnie; Green, Jennifer Greif

    2014-07-01

    The majority of research on terrorism-exposed youth has examined large-scale terrorism with mass casualties. Limited research has examined children's reactions to terrorism of the scope of the Boston Marathon bombing. Furthermore, the extraordinary postattack interagency manhunt and shelter-in-place warning made for a truly unprecedented experience in its own right for families. Understanding the psychological adjustment of Boston-area youth in the aftermath of these events is critical for informing clinical efforts. Survey of Boston-area parents/caretakers (N = 460) reporting on their child's experiences during the attack week, as well as psychosocial functioning in the first 6 attack months. There was heterogeneity across youth in attack- and manhunt-related experiences and clinical outcomes. The proportion of youth with likely attack/manhunt-related posttraumatic stress disorder (PTSD) was roughly 6 times higher among Boston Marathon-attending youth than nonattending youth. Attack and manhunt experiences each uniquely predicted 9% of PTSD symptom variance, with manhunt exposures more robustly associated than attack-related exposures with a range of psychosocial outcomes, including emotional symptoms, conduct problems, hyperactivity/inattention, and peer problems. One-fifth of youth watched >3 hours of televised coverage on the attack day, which was linked to PTSD symptoms, conduct problems, and total difficulties. Prosocial behavior and positive peer functioning buffered the impact of exposure. Clinical efforts must maintain a broadened focus beyond simply youth present at the blasts and must also include youth highly exposed to the intense interagency pursuit and manhunt. Continued research is needed to understand the adjustment of youth after mass traumas and large-scale manhunts in residential communities. Copyright © 2014 by the American Academy of Pediatrics.

  3. Media's role in broadcasting acute stress following the Boston Marathon bombings.

    Science.gov (United States)

    Holman, E Alison; Garfin, Dana Rose; Silver, Roxane Cohen

    2014-01-07

    We compared the impact of media vs. direct exposure on acute stress response to collective trauma. We conducted an Internet-based survey following the Boston Marathon bombings between April 29 and May 13, 2013, with representative samples of residents from Boston (n = 846), New York City (n = 941), and the remainder of the United States (n = 2,888). Acute stress symptom scores were comparable in Boston and New York [regression coefficient (b) = 0.43; SE = 1.42; 95% confidence interval (CI), -2.36, 3.23], but lower nationwide when compared with Boston (b = -2.21; SE = 1.07; 95% CI, -4.31, -0.12). Adjusting for prebombing mental health (collected prospectively), demographics, and prior collective stress exposure, six or more daily hours of bombing-related media exposure in the week after the bombings was associated with higher acute stress than direct exposure to the bombings (continuous acute stress symptom total: media exposure b = 15.61 vs. direct exposure b = 5.69). Controlling for prospectively collected prebombing television-watching habits did not change the findings. In adjusted models, direct exposure to the 9/11 terrorist attacks and the Sandy Hook School shootings were both significantly associated with bombing-related acute stress; Superstorm Sandy exposure wasn't. Prior exposure to similar and/or violent events may render some individuals vulnerable to the negative effects of collective traumas. Repeatedly engaging with trauma-related media content for several hours daily shortly after collective trauma may prolong acute stress experiences and promote substantial stress-related symptomatology. Mass media may become a conduit that spreads negative consequences of community trauma beyond directly affected communities.

  4. School- and Classroom-Based Supports for Children Following the 2013 Boston Marathon Attack and Manhunt.

    Science.gov (United States)

    Green, Jennifer Greif; Holt, Melissa K; Kwong, Lana; Reid, Gerald; Xuan, Ziming; Comer, Jonathan S

    2015-06-01

    School staff provide key mental health services following mass crisis events and teachers, in particular, can provide important supports within their classrooms. This study examines Boston-area teachers' perception of classroom-wide psychiatric distress and the types of supports that schools and teachers provided following the 2013 Boston Marathon bombing and subsequent manhunt. Boston-area K-12 teachers (N = 147) in communities with varying levels of exposure to the bombing and manhunt completed an anonymous web-based survey 2-5 months after the attack. Teachers reported on students' exposure to the bombings and manhunt, classroom-wide psychiatric distress, and the types of supports they and their schools provided students. Teacher reports of student exposure to the bombings and manhunt were significantly associated with their perceptions of greater classroom-wide psychiatric distress. Almost half indicated that their school had no formal policy for responding to the crisis, half reported no training to address events, and even the most common classroom-based support strategy-reassuring students of their safety-was provided by only 76 % of teachers. Teacher perceptions of student exposure to the manhunt, but not the bombing, were significantly associated with greater provision of these supports. In the aftermath of the Boston Marathon bombings and manhunt, teachers and schools provided supports; however, the extent and types of supports varied considerably. Working with teachers to most effectively and consistently serve in this complex role has the potential to improve school-based crisis response plans, as well as student outcomes.

  5. Media’s role in broadcasting acute stress following the Boston Marathon bombings

    Science.gov (United States)

    Holman, E. Alison; Garfin, Dana Rose; Silver, Roxane Cohen

    2014-01-01

    We compared the impact of media vs. direct exposure on acute stress response to collective trauma. We conducted an Internet-based survey following the Boston Marathon bombings between April 29 and May 13, 2013, with representative samples of residents from Boston (n = 846), New York City (n = 941), and the remainder of the United States (n = 2,888). Acute stress symptom scores were comparable in Boston and New York [regression coefficient (b) = 0.43; SE = 1.42; 95% confidence interval (CI), −2.36, 3.23], but lower nationwide when compared with Boston (b = −2.21; SE = 1.07; 95% CI, −4.31, −0.12). Adjusting for prebombing mental health (collected prospectively), demographics, and prior collective stress exposure, six or more daily hours of bombing-related media exposure in the week after the bombings was associated with higher acute stress than direct exposure to the bombings (continuous acute stress symptom total: media exposure b = 15.61 vs. direct exposure b = 5.69). Controlling for prospectively collected prebombing television-watching habits did not change the findings. In adjusted models, direct exposure to the 9/11 terrorist attacks and the Sandy Hook School shootings were both significantly associated with bombing-related acute stress; Superstorm Sandy exposure wasn't. Prior exposure to similar and/or violent events may render some individuals vulnerable to the negative effects of collective traumas. Repeatedly engaging with trauma-related media content for several hours daily shortly after collective trauma may prolong acute stress experiences and promote substantial stress-related symptomatology. Mass media may become a conduit that spreads negative consequences of community trauma beyond directly affected communities. PMID:24324161

  6. Conflictual Media Events, Eyewitness Images, and the Boston Marathon Bombing (2013)

    DEFF Research Database (Denmark)

    Mortensen, Mette

    2015-01-01

    The proliferation of camera phones over the past decade has created an unprecedented landslide of visual information in the online public sphere, transforming the form and amount of communication in relation to crisis events. International research on this subject has primarily centered on the wa...... boundaries between experts and laymen and between professionals and non-professionals in relation to conflictual media events. The bombing of the Boston Marathon in April 2013 constitutes the empirical point of departure....

  7. Mortality Among Homeless Adults in Boston: Shifts in Causes of Death Over a 15-year Period

    Science.gov (United States)

    Baggett, Travis P.; Hwang, Stephen W.; O'Connell, James J.; Porneala, Bianca C.; Stringfellow, Erin J.; Orav, E. John; Singer, Daniel E.; Rigotti, Nancy A.

    2013-01-01

    Background Homeless persons experience excess mortality, but U.S.-based studies on this topic are outdated or lack information about causes of death. No studies have examined shifts in causes of death for this population over time. Methods We assessed all-cause and cause-specific mortality rates in a cohort of 28,033 adults aged 18 years or older who were seen at Boston Health Care for the Homeless Program between January 1, 2003, and December 31, 2008. Deaths were identified through probabilistic linkage to the Massachusetts death occurrence files. We compared mortality rates in this cohort to rates in the 2003–08 Massachusetts population and a 1988–93 cohort of homeless adults in Boston using standardized rate ratios with 95% confidence intervals. Results 1,302 deaths occurred during 90,450 person-years of observation. Drug overdose (n=219), cancer (n=206), and heart disease (n=203) were the major causes of death. Drug overdose accounted for one-third of deaths among adults homeless adults in Boston remains high and unchanged since 1988–93 despite a major interim expansion in clinical services. Drug overdose has replaced HIV as the emerging epidemic. Interventions to reduce mortality in this population should include behavioral health integration into primary medical care, public health initiatives to prevent and reverse drug overdose, and social policy measures to end homelessness. PMID:23318302

  8. Geospatial clustering in sugar-sweetened beverage consumption among Boston youth.

    Science.gov (United States)

    Tamura, Kosuke; Duncan, Dustin T; Athens, Jessica K; Bragg, Marie A; Rienti, Michael; Aldstadt, Jared; Scott, Marc A; Elbel, Brian

    2017-09-01

    The objective was to detect geospatial clustering of sugar-sweetened beverage (SSB) intake in Boston adolescents (age = 16.3 ± 1.3 years [range: 13-19]; female = 56.1%; White = 10.4%, Black = 42.6%, Hispanics = 32.4%, and others = 14.6%) using spatial scan statistics. We used data on self-reported SSB intake from the 2008 Boston Youth Survey Geospatial Dataset (n = 1292). Two binary variables were created: consumption of SSB (never versus any) on (1) soda and (2) other sugary drinks (e.g., lemonade). A Bernoulli spatial scan statistic was used to identify geospatial clusters of soda and other sugary drinks in unadjusted models and models adjusted for age, gender, and race/ethnicity. There was no statistically significant clustering of soda consumption in the unadjusted model. In contrast, a cluster of non-soda SSB consumption emerged in the middle of Boston (relative risk = 1.20, p = .005), indicating that adolescents within the cluster had a 20% higher probability of reporting non-soda SSB intake than outside the cluster. The cluster was no longer significant in the adjusted model, suggesting spatial variation in non-soda SSB drink intake correlates with the geographic distribution of students by race/ethnicity, age, and gender.

  9. ULTRA-WIDEFIELD IMAGING OF POSTERIOR SEGMENT PATHOLOGY IN THE SETTING OF THE BOSTON KERATOPROSTHESIS.

    Science.gov (United States)

    Kornberg, Daniel L; Yannuzzi, Nicolas A; Klufas, Michael A; DʼAmico, Donald J; Orlin, Anton; Kiss, Szilárd

    2016-06-01

    To evaluate the ability to visualize and document posterior segment pathology through the Boston keratoprosthesis (KPro) using the Optos P200Tx ultra-widefield (UWF) scanning laser ophthalmoscope. A retrospective chart review was conducted of patients who underwent Boston Type I keratoprosthesis implantation and who subsequently were imaged with an UWF system. Ultra-widefield images were reviewed to evaluate for vitreoretinal pathology and were compared with the clinical examination. In this series of 10 patients (10 eyes), 100% of vitreoretinal pathology found on clinical examination was detectable using the Optos system. In 4 cases (40%), UWF imaging provided superior detection of pathology compared with the clinical examination by imaging through retroprosthetic membranes (3 cases) and by detection of a retinal detachment (one case). In 1 case (10%), B-scan ultrasonography was needed to characterize vitreoretinal pathology that could not be definitively distinguished on UWF imaging and was difficult to detect on clinical examination. Ultra-widefield imaging detected the following vitreoretinal pathologies in KPro eyes: retinal hemorrhage, epiretinal membrane, retinal detachment, proliferative diabetic retinopathy, and choroidal folds. Ultra-widefield imaging provides a high-resolution view of the posterior pole and periphery despite the limitations of imaging through the narrow optic of Boston Type I keratoprosthesis, and it may improve visualization through retroprosthetic membranes. Detection and documentation of vitreoretinal complications in the setting of a permanent keratoprosthesis may be enhanced using UWF imaging.

  10. Crisis communication: an inequalities perspective on the 2010 Boston water crisis.

    Science.gov (United States)

    Galarce, Ezequiel M; Viswanath, K

    2012-12-01

    Although the field of crisis risk communication has generated substantial research, the interaction between social determinants, communication processes, and behavioral compliance has been less well studied. With the goal of better understanding these interactions, this report examines how social determinants influenced communications and behavioral compliance during the 2010 Boston, Massachusetts, water crisis. An online survey was conducted to assess Boston residents' knowledge, beliefs, attitudes, mass and interpersonal communication, and preventive behaviors on emergency preparedness topics dealing with the water crisis. Of a total sample of 726 respondents, approximately one-third (n = 267) reported having been affected by the water crisis. Only data from affected participants were analyzed. Following an order to boil water, 87.5% of respondents refrained from drinking unboiled tap water. These behaviors and other cognitive and attitudinal factors, however, were not uniform across population subgroups. All communication and behavioral compliance variables varied across sociodemographic factors. Crisis communication, in conjunction with other public health preparedness fields, is central to reducing the negative impact of sudden hazards. Emergency scenarios such as the Boston water crisis serve as unique opportunities to understand how effectively crisis messages are conveyed to and received by different segments of the population.

  11. Head and neck injuries from the Boston Marathon bombing at four hospitals.

    Science.gov (United States)

    Singh, Ajay K; Buch, Karen; Sung, Edward; Abujudeh, Hani; Sakai, Osamu; Aaron, Sodickson; Lev, Michael

    2015-10-01

    The aim of this study was to evaluate the imaging findings of head and neck injuries in patients from the Boston Marathon bombing. A total of 115 patients from the Boston Marathon bombing presenting to four hospitals who underwent imaging to evaluate for head and neck injuries were included in the study. Twelve patients with positive findings on radiography or cross-sectional imaging were included in the final analysis. The radiographic, computed tomography (CT), and magnetic resonance (MR) imaging features of these patients were evaluated for the presence of shrapnel and morphological abnormality. Head and neck injuries were seen in 12 out of 115 patients presenting to the four hospitals. There were secondary blast injuries to the head and neck in eight patients, indicated by the presence of shrapnel on imaging. In the four patients without shrapnel, there were two with subgaleal hematomas, one with facial contusion and one with mastoid injury. There were two patients with subarachnoid hemorrhage, one with brain contusion, one with cerebral laceration, and one with globe rupture. There was frontal bone, nasal bone, and orbital wall fracture in one patient each. Imaging identified 26 shrapnel fragments, 21 of which were ball bearings. Injuries to the head and neck region identified on imaging from the Boston Marathon bombing were not common. The injuries seen were predominantly secondary blast injuries from shrapnel, and did not result in calvarial penetration of the shrapnel fragments.

  12. Real-time sample entropy predicts life-saving interventions after the Boston Marathon bombing.

    Science.gov (United States)

    Peev, Miroslav P; Naraghi, Leily; Chang, Yuchiao; Demoya, Marc; Fagenholz, Peter; Yeh, Daniel; Velmahos, George; King, David R

    2013-12-01

    Identifying patients in need of a life-saving intervention (LSI) during a mass casualty event is a priority. We hypothesized that real-time, instantaneous sample entropy (SampEn) could predict the need for LSI in the Boston Marathon bombing victims. Severely injured Boston Marathon bombing victims (n = 10) had sample entropy (SampEn) recorded upon presentation using a continuous 200-beat rolling average in real time. Treating clinicians were blinded to real-time results. The correlation between SampEn, injury severity, number, and type of LSI was examined. Victims were males (60%) with a mean age of 39.1 years. Injuries involved lower extremities (50.0%), head and neck (24.2%), or upper extremities (9.7%). Sample entropy negatively correlated with Injury Severity Score (r = -0.70; P = .023), number of injuries (r = -0.70; P = .026), and the number and need for LSI (r = -0.82; P = .004). Sample entropy was reduced under a variety of conditions. (Table see text). Sample entropy strongly correlates with injury severity and predicts LSI after blast injuries sustained in the Boston Marathon bombings. Sample entropy may be a useful triage tool after blast injury. © 2013.

  13. Human Papillomavirus infection in men residing in Brazil, Mexico, and the USA Infección por Virus de Papiloma Humano en hombres de Brasil, México y EUA

    Directory of Open Access Journals (Sweden)

    2008-10-01

    Virus del Papiloma Humano (VPH entre hombres de 18 años o más de tres países con un protocolo común para el muestreo de la detección de VPH, y evaluar si la detección de VPH varía de acuerdo con la edad y el país. MATERIAL Y MÉTODOS: El estudio incluye diversas etapas que inician con la identificación de hombres susceptibles, una medición basal (visita de enrolamiento y nueve visitas adicionales programadas cada seis meses. En este artículo, se presenta el análisis de los primeros 1160 hombres que fueron incluídos en el estudio. Para maximizar la posibilidad de detección de VPH se utilizó un cepillo de dacrón que muestreó en forma combinada diferentes sitios anatómicos. Para la determinación de ADN de VPH se utilizó ión en cadena de polimerasa (PCR por amplificación de un fragmento del gen de VPH L1. RESULTADOS: Entre 1160 hombres de Brasil, México y EUA, la prevalencia global de VPH fue de 65.2%, con solamente 12% de tipos oncogénicos, 20.7% de tipos de VPH no oncogénicos, 17.8% de muestras positivas a tipos oncogénicos y no oncogénicos; y finalmente 14.7% de infecciones no clasificadas. Múltiples tipos de VPH fueron detectados en 25.7% de los participantes en el estudio. La prevalencia de VPH fue más alta en Brasil (72.3%, comparada con la observada en EUA (61.3% y México (61.9%. Los tipos de VPH 16 (6.5%, 51 (6.5% y 59 (5.3% fueron los más comúnmente observados con poder oncogénico. El VPH 84 (7.7%, 62 (7.3% y 6 (6.6% fueron las infecciones no oncogénicas más comunes. CONCLUSIONES: Son necesarios estudios de la distribución de VPH en un amplio margen de edad entre hombres de múltiples países, para establecer con mayor precisión, el conocimiento de la historia natural de la infección por VPH en hombres.

  14. Contextualizing Earth Science Professional Development Courses for Geoscience Teachers in Boston

    Science.gov (United States)

    Chen, R. F.; Pelletier, P.; Dorsen, J.; Douglas, E. M.; Pringle, M. S.; Karp, J.

    2009-12-01

    Inquiry-based, hands-on, graduate content courses have been developed specifically for Boston Public School middle school teachers of Earth Science. Earth Science I: Weather and Water and Earth Science II: The Solid Earth--Earth History and Planetary Systems have been taught a total of seven times to over 120 teachers. Several key attributes to these successful courses have been identified, including co-instruction by a university professor and a high school and a middle school teacher that are familiar with the Boston curriculum, use of hands-on activities that are closed related to those used in the Boston curriculum, pre- and post-course local field trips, and identification of key learning objectives for each day. This model of professional development was developed over several years in all disciplines (Earth Science, Physics, Biology, Chemistry) by the Boston Science Partnership (BSP), an NSF-funded Math Science Partnership program. One of the core strategies of the BSP is these Contextualized Content Courses (CCC), graduate level, lab-based courses taught at either UMass Boston or Northeastern University during summer intensive or semester formats. Two of the eleven courses developed under the grant are Earth Science I & II. This presentation shares the model of the CCC, the impact on teacher participants, the value of these courses for the professor, and lessons learned for successful professional development. Findings about the courses’ impact and effectiveness come from our external evaluation by the Program Evaluation Research Group (PERG). The combination of content and modeling good instructional practices have many positive outcomes for teachers, including increased self-efficacy in science understanding and teaching, positive impacts on student achievement, and teacher shifts from more traditional, more lecture-based instructional models to more inquiry approaches. STEM faculty members become involved in science education and learn and practice new

  15. Patagifer lamothei n. sp. (Digenea: Echinostomatidae: Nephrostominae from the white ibis Eudocimus albus (Threskiornithidae from Texas, USA Patagifer lamothei n. sp. (Digenea: Echinostomatidae: Nephrostominae del ibis blanco Eudocimus albus (Threkiornithidae de Texas, EUA

    Directory of Open Access Journals (Sweden)

    Norman O. Dronen

    2008-08-01

    Eudocimus albus (Linnaeus (Threskiornithidae procedentes de los condados de Galveston y Brazos, Texas, EUA. Patagifer lamothei n. sp. se puede distinguir de P. bilobus (Rudolphi, 1819, P. brygooi Richard, 1964, P. consimilis Dietz, 1909, y P. fraternus Johnston, 1917, por la posición de los testículos, contiguos o casi, por la distancia entre el ovario y el testículo anterior que es menor que la longitud del ovario, y el espacio postesticular que es menos extenso, por tener el espacio intertesticular aproximadamente igual o mayor que la longitud del ovario, por el ovario ubicado a una distancia del testículo anterior igual o mayor que la longitud del ovario, y por tener un espacio postesticular más extenso. Además, el ovario de la especie nueva se localiza justamente delante de la mitad corporal, a diferencia de P. bilobus, P. fraternus y P. vioscai Lumsden, 1962, en los cuales se encuentra en la mitad del cuerpo y de P. brygooi y P. consimilis, donde se ubica en la mitad posterior. La especie nueva se asemeja a P. simarai Nigam, 1944 por la distancia entre los testículos, la posición del ovario y el espacio postesticular (30 y 36% de la longitud corporal. Sin embargo, difiere de P. simarai por el cuerpo de menor tamaño, por poseer faringe, ventosa oral y ventral, ovario, testículos y bolsa del cirro, todos ellos de menor tamaño y por presentar espinas pequeñas en el margen del collar y espinas de mayor tamaño en los ángulos del mismo. Adicionalmente, el ovario de la especie nueva se localiza inmediatamente anterior al punto medio corporal, mientras que en P. simarai, se localiza bastante adelante de dicho punto.

  16. Surface wave site characterization at 27 locations near Boston, Massachusetts, including 2 strong-motion stations

    Science.gov (United States)

    Thompson, Eric M.; Carkin, Bradley A.; Baise, Laurie G.; Kayen, Robert E.

    2014-01-01

    The geotechnical properties of the soils in and around Boston, Massachusetts, have been extensively studied. This is partly due to the importance of the Boston Blue Clay and the extent of landfill in the Boston area. Although New England is not a region that is typically associated with seismic hazards, there have been several historical earthquakes that have caused significant ground shaking (for example, see Street and Lacroix, 1979; Ebel, 1996; Ebel, 2006). The possibility of strong ground shaking, along with heightened vulnerability from unreinforced masonry buildings, motivates further investigation of seismic hazards throughout New England. Important studies that are pertinent to seismic hazards in New England include source-parameter studies (Somerville and others, 1987; Boore and others, 2010), wave-propagation studies (Frankel, 1991; Viegas and others, 2010), empirical ground-motion prediction equations (GMPE) for computing ground-motion intensity (Tavakoli and Pezeshk, 2005; Atkinson and Boore, 2006), site-response studies (Hayles and others, 2001; Ebel and Kim, 2006), and liquefaction studies (Brankman and Baise, 2008). The shear-wave velocity (VS) profiles collected for this report are pertinent to the GMPE, site response, and liquefaction aspects of seismic hazards in the greater Boston area. Besides the application of these data for the Boston region, the data may be applicable throughout New England, through correlations with geologic units (similar to Ebel and Kim, 2006) or correlations with topographic slope (Wald and Allen, 2007), because few VS measurements are available in stable tectonic regions.Ebel and Hart (2001) used felt earthquake reports to infer amplification patterns throughout the greater Boston region and noted spatial correspondence with the dominant period and amplification factors obtained from ambient noise (horizontal-to-vertical ratios) by Kummer (1998). Britton (2003) compiled geotechnical borings in the area and produced a

  17. Microbial keratitis after Boston type I keratoprosthesis implantation: incidence, organisms, risk factors, and outcomes.

    Science.gov (United States)

    Kim, Michelle J; Yu, Fei; Aldave, Anthony J

    2013-11-01

    To identify the incidence of and risk factors for microbial keratitis after implantation of the Boston type I keratoprosthesis (Massachusetts Eye and Ear Infirmary, Boston, MA). Retrospective, single-surgeon consecutive case series. A total of 105 patients (125 keratoprosthesis procedures in 110 eyes) who underwent Boston type I keratoprosthesis implantation at the Jules Stein Eye Institute between May 1, 2004, and April 1, 2012. Data regarding ocular history, relevant intraoperative data, postoperative management, and outcomes were collected for each procedure. Risk factor analyses were performed using the Fisher exact test, log-rank test, and hazard ratio (HR). Incidence of microbial keratitis, organisms responsible, risk factors, and outcomes. During the period under review, 20 presumed infectious infiltrates were diagnosed in 15 eyes (13.6%) of 15 patients (14.3%), for a rate of 0.073 infections per eye-year. The rate of culture-positive bacterial keratitis was 0.022 infections per eye-year, and the rate of culture-positive fungal keratitis was 0.015 infections per eye-year. Topical vancomycin use, topical steroid use, and contact lens wear did not increase the incidence of infectious keratitis, but prolonged vancomycin use was associated with an increased risk for fungal keratitis and infectious keratitis overall. Persistent corneal epithelial defect formation also was associated with an increased incidence of fungal keratitis and infectious keratitis overall. There were no cases of endophthalmitis resulting from infectious keratitis. Infectious keratitis develops in 13.6% of eyes after keratoprosthesis implantation, with a similar rate of culture-positive bacterial and fungal keratitis. The observed rate of microbial keratitis suggests the need for additional topical antimicrobial prophylaxis after keratoprosthesis implantation in eyes at higher risk, such as those with persistent corneal epithelial defect formation or prolonged vancomycin use. Copyright

  18. Vision retention in early versus delayed glaucoma surgical intervention in patients with Boston Keratoprosthesis type 1.

    Directory of Open Access Journals (Sweden)

    Mark Lin

    Full Text Available The loss of vision following Boston Keratoprosthesis (BKPro surgery due to glaucoma occurs at a high frequency as diagnosis and management of glaucoma after this procedure pose challenges.To compare visual outcomes in patients undergoing Boston Keratoprosthesis surgery with and without prior or concurrent glaucoma surgery.This is a retrospective, observational cohort study of patients who underwent Boston Type I Keratoprosthesis surgery. 19 eyes of 18 patients who had undergone BKPro and met the inclusion criteria were identified. Twelve eyes received BKPro with prior or concurrent glaucoma surgery (Group 1, and seven eyes were identified undergoing BKPro surgery without prior or concurrent glaucoma surgery (Group 2.Main outcome included best corrected visual acuity at each follow up.In Group 1, mean best corrected visual acuity (BCVA within a year of BKPro surgery was 20/100 (range 20/40 to Count Fingers (CF; n = 12 and mean BCVA at 1 year from BKPro surgery was 20/115 (range 20/30 to CF; n = 12. 7 out of 12 patients retained or had improved BCVA at 1 year follow up after BKPro implantation, and 5 out of 12 patients had mild BCVA worsening. In Group 2, the mean BCVA within a year of BKPro surgery was 20/140 (ranging from 20/25 to hand motion vision (HM; n = 7 and mean BCVA at 1 year from BKPro surgery was Count Fingers (range 20/60 to Light Perception (LP; n = 6. 4 out of 6 patients lost significant vision at one year after BKPro.BKPro patients with early glaucoma surgical intervention retained vision significantly better compared to patients with late or no intervention. Our preliminary findings support the recommendation for concurrent or pre-emptive glaucoma surgical intervention in patients undergoing BKPro implantation.

  19. Vision retention in early versus delayed glaucoma surgical intervention in patients with Boston Keratoprosthesis type 1.

    Science.gov (United States)

    Lin, Mark; Bhatt, Anand; Haider, Asghar; Kim, Grace; Farid, Marjan; Schmutz, Mason; Mosaed, Sameh

    2017-01-01

    The loss of vision following Boston Keratoprosthesis (BKPro) surgery due to glaucoma occurs at a high frequency as diagnosis and management of glaucoma after this procedure pose challenges. To compare visual outcomes in patients undergoing Boston Keratoprosthesis surgery with and without prior or concurrent glaucoma surgery. This is a retrospective, observational cohort study of patients who underwent Boston Type I Keratoprosthesis surgery. 19 eyes of 18 patients who had undergone BKPro and met the inclusion criteria were identified. Twelve eyes received BKPro with prior or concurrent glaucoma surgery (Group 1), and seven eyes were identified undergoing BKPro surgery without prior or concurrent glaucoma surgery (Group 2). Main outcome included best corrected visual acuity at each follow up. In Group 1, mean best corrected visual acuity (BCVA) within a year of BKPro surgery was 20/100 (range 20/40 to Count Fingers (CF); n = 12) and mean BCVA at 1 year from BKPro surgery was 20/115 (range 20/30 to CF; n = 12). 7 out of 12 patients retained or had improved BCVA at 1 year follow up after BKPro implantation, and 5 out of 12 patients had mild BCVA worsening. In Group 2, the mean BCVA within a year of BKPro surgery was 20/140 (ranging from 20/25 to hand motion vision (HM); n = 7) and mean BCVA at 1 year from BKPro surgery was Count Fingers (range 20/60 to Light Perception (LP); n = 6). 4 out of 6 patients lost significant vision at one year after BKPro. BKPro patients with early glaucoma surgical intervention retained vision significantly better compared to patients with late or no intervention. Our preliminary findings support the recommendation for concurrent or pre-emptive glaucoma surgical intervention in patients undergoing BKPro implantation.

  20. Short-Term Visual Outcomes of Boston Keratoprosthesis Type I in Saudi Arabia

    Science.gov (United States)

    Al Arfaj, Khalid; Hantera, Mohamed

    2012-01-01

    Purpose: To evaluate the visual outcomes, complications and retention of threadless type I Boston keratoprosthesis (KPro) in Saudi Arabia. Materials and Methods: Retrospective analysis of four eyes of four patients (one female and three males; age range: 48 to 72 years) who underwent Boston type I threadless KPro implantation between January and December 2009. Results: In the median follow-up of 11 months (range 6 to 14 months), visual outcomes were satisfactory. Preoperative diagnosis included two patients of post-trachoma dense vascularized corneal scarring, one patient of corneal alkali burn and one patient of repeated failed corneal grafts. All patients demonstrated significant improvement in vision; with pre-operative visual acuity of hand movements (HM), counting fingers and HM improved to best corrected visual acuity (BCVA) of 20/200, 20/60, 20/50 and 20/30 on their last follow-up visits respectively. None of the patients developed glaucoma as a result of the procedure. No retro-prosthetic membrane developed till the last follow-up visit. One of the four patients had a corneal melt (due to severe dryness associated with trachoma) 6 months after the KPro implantation and underwent a successful KPro revision. Despite the relatively poor prognosis expected in alkali burn eye, the patient attained the maximum BCVA (20/30) of the four eye series on the last follow-up visit at six months. Conclusion: In consistent with the earlier reports from other parts of the world, all the 4 eyes had a significant increase in vision after Boston type I KPro implantation. However, patients require close lifelong follow-up to manage any complications. PMID:22346120

  1. Visual outcomes of Boston keratoprosthesis implantation as the primary penetrating corneal procedure.

    Science.gov (United States)

    Kang, Joann J; de la Cruz, Jose; Cortina, Maria Soledad

    2012-12-01

    To report the short-term visual outcomes and complications of keratoprosthesis surgery as the primary penetrating corneal procedure for patients at high risk for conventional corneal transplantation. A retrospective chart review was conducted of 21 eyes of 19 patients who underwent either Boston keratoprosthesis type I or type II as the primary penetrating corneal procedure from February 2007 to March 2011. Nineteen type I (90.5%) and 2 type II (9.5%) Boston keratoprosthesis procedures were performed in 19 patients. Mean follow-up was 14.6 months (range, 6-36.3 mo). Primary indications for surgery included chemical or thermal injury, aniridia, and Stevens-Johnson syndrome. Preoperative best-corrected visual acuity (BCVA) ranged from 20/100 to light perception and was count fingers or worse in 20 eyes (95.2%). At last follow-up for all eyes, 15 eyes (71.4%) achieved BCVA≥20/200 and 4 eyes (19%) improved to BCVA≥20/50. No intraoperative complications occurred. Postoperative complications include retroprosthetic membrane formation (47.6%), cystoid macular edema (33.3%), elevated intraocular pressure (23.8%), glaucoma progression (14.3%), and endophthalmitis (4.8%). The initial keratoprosthesis was retained in 19 eyes (90.5%). The Boston keratoprosthesis, based on early follow-up, is a good alternative as a primary penetrating corneal procedure in a select group of patients with very poor prognosis for penetrating keratoplasty. Although complications can occur and require close monitoring, visual acuity significantly improved in the majority of patients.

  2. Outcomes of pars plana glaucoma drainage implant in Boston type 1 keratoprosthesis surgery.

    Science.gov (United States)

    Huh, Eun S; Aref, Ahmad A; Vajaranant, Thasarat S; de la Cruz, Jose; Chau, Felix Y; Cortina, Maria S

    2014-01-01

    Glaucoma drainage implantation in conjunction with Boston Type 1 Keratoprosthesis placement is a surgical option in controlling postoperative glaucoma. The purpose of this study is to report outcomes of combined pars plana vitrectomy and glaucoma drainage implantation with corneal patch graft in Boston Type 1 Keratoprosthesis patients. A retrospective review of patients who underwent pars plana glaucoma drainage implantation in combination with Boston Type 1 Keratoprosthesis was performed. Preoperative and postoperative parameters collected and analyzed included: visual acuity, intraocular pressure, number of glaucoma medications to achieve intraocular pressure control, bandage contact lens fit, and postoperative complications. Twenty eyes of 20 patients were identified; 95% had preoperative diagnosis of glaucoma, utilizing on an average 2.5 medications with an average intraocular pressure of 19.8 mm Hg (±6.3 mm Hg; range, 9 to 32.8 mm Hg). After placement of the pars plana glaucoma drainage implant, an average intraocular pressure of 19 mm Hg (±7.0 mm Hg; range, 8 to 30 mm Hg) by scleral pneumotonometry was achieved and 85% were deemed to have normal pressures by digital palpation. An average of 2.1 intraocular pressure-lowering medications were required on last follow-up. Average follow-up was 31.6 months (±17.4 mo; range, 12.3 to 71.6 mo). Two eyes required glaucoma drainage implant explantation: one eye due to endophthalmitis from a nonhealing corneal ulcer and the other eye due to corneal melt. None of our patients experienced conjunctival erosion over a pars plana positioned glaucoma drainage implant or tube. For the long-term management of glaucoma in keratoprosthesis patients, a posteriorly placed pars plana glaucoma drainage implant with corneal patch graft in conjunction with keratoprosthesis has a low risk of erosion and postoperative complications.

  3. Application of Boston matrix combined with SWOT analysis on operational development and evaluations of hospital development.

    Science.gov (United States)

    Tao, Z-Q; Shi, A-M

    2016-05-01

    The aim of this study is to explore the application of Boston matrix combined with SWOT analysis on operational development and evaluations of hospital departments. We selected 73 clinical and medical technology departments of our hospital from 2011 to 2013, and evaluated our hospital by Boston matrix combined with SWOT analysis according to the volume of services, medical quality, work efficiency, patients' evaluations, development capacity, operational capability, economic benefits, comprehensive evaluation of hospital achievement, innovation ability of hospital, influence of hospital, human resources of hospital, health insurance costs, etc. It was found that among clinical departments, there were 11 in Stars (22.4%), 17 in cash cow (34.7%), 15 in question marks (31.2%), 6 Dogs (12.2%), 16 in the youth stage of life cycle assessment (27.6%), 14 in the prime stage (24.1%), 12 in the stationary stage (20.7%), 9 in the aristocracy stage (15.5%) and 7 in the recession stage (12.1%). Among medical technology departments, there were 5 in Stars (20.8%), 1 in Cash cow (4.2%), 10 in question marks (41.6%), 8 Dogs (29.1%), 9 in the youth stage of life cycle assessment (37.5%), 4 in the prime stage (16.7%), 4 in the stable stage (16.7%), 1 in the aristocracy stage (4.2%) and 6 in the recession stage (25%). In conclusion, Boston matrix combined with SWOT analysis is suitable for operational development and comprehensive evaluations of hospital development, and it plays an important role in providing hospitals with development strategies.

  4. A new spin on research translation: the Boston Consensus Conference on Human Biomonitoring.

    Science.gov (United States)

    Nelson, Jessica W; Scammell, Madeleine Kangsen; Altman, Rebecca Gasior; Webster, Thomas F; Ozonoff, David M

    2009-04-01

    Translating research to make it more understandable and effective (research translation) has been declared a priority in environmental health but does not always include communication to the public or residents of communities affected by environmental hazards. Their unique perspectives are also commonly missing from discussions about science and technology policy. The consensus conference process, developed in Denmark, offers a way to address this gap. The Boston Consensus Conference on Human Biomonitoring, held in Boston, Massachusetts, in the fall of 2006, was designed to educate and elicit input from 15 Boston-area residents on the scientifically complex topic of human biomonitoring for environmental chemicals. This lay panel considered the many ethical, legal, and scientific issues surrounding biomonitoring and prepared a report expressing their views. The lay panel's findings provide a distinct and important voice on the expanding use of biomonitoring. In some cases, such as a call for opt-in reporting of biomonitoring results to study participants, they mirror recommendations raised elsewhere. Other conclusions have not been heard previously, including the recommendation that an individual's results should be statutorily exempted from the medical record unless permission is granted, and the opportunity to use biomonitoring data to stimulate green chemistry. The consensus conference model addresses both aspects of a broader conception of research translation: engaging the public in scientific questions, and bringing their unique perspectives to bear on public health research, practice, and policy. In this specific application, a lay panel's recommendations on biomonitoring surveillance, communication, and ethics have practical implications for the conduct of biomonitoring studies and surveillance programs.

  5. Self-reported safety belt use among emergency department patients in Boston, Massachusetts

    Directory of Open Access Journals (Sweden)

    Mitchell Patricia

    2006-04-01

    Full Text Available Abstract Background Safety belt use is 80% nationally, yet only 63% in Massachusetts. Safety belt use among potentially at-risk groups in Boston is unknown. We sought to assess the prevalence and correlates of belt non-use among emergency department (ED patients in Boston. Methods A cross-sectional survey with systematic sampling was conducted on non-urgent ED patients age ≥18. A closed-ended survey was administered by interview. Safety belt use was defined via two methods: a single-item and a multiple-item measure of safety belt use. Each was scored using a 5-point frequency scale. Responses were used to categorize safety belt use as 'always' or less than 'always'. Outcome for multivariate logistic regression analysis was safety belt use less than 'always'. Results Of 478 patients approached, 381 (80% participated. Participants were 48% female, 48% African-American, 40% White, median age 39. Among participants, 250 (66% had been in a car crash; 234 (61% had a valid driver's license, and 42 (11% had been ticketed for belt non-use. Using two different survey measures, a single-item and a multiple-item measure, safety belt use 'always' was 51% and 36% respectively. According to separate regression models, factors associated with belt non-use included male gender, alcohol consumption >5 drinks in one episode, riding with others that drink and drive, ever receiving a citation for belt non-use, believing that safety belt use is 'uncomfortable', and that 'I just forget', while 'It's my usual habit' was protective. Conclusion ED patients at an urban hospital in Boston have considerably lower self-reported safety belt use than state or national estimates. An ED-based intervention to increase safety belt use among this hard-to-reach population warrants consideration.

  6. As relações Colômbia, países vizinhos e Estados Unidos: visões em torno da agenda de segurança Relations between Colombia, its neighbours and the United States: views on the Security Agenda

    Directory of Open Access Journals (Sweden)

    Rafael Duarte Villa

    2005-12-01

    Full Text Available Este artigo trabalha a tese de que a agenda de segurança dos EUA para Colômbia, que adquire expressão concreta em mecanismos como o Plano Colômbia e a Iniciativa Regional Andina, continuará sendo o eixo central da política de segurança na região sul-americana. No entanto, a noção de segurança que têm em mente os decisions makers dos EUA no caso colombiano reflete uma visão nas percepções de ameaças na que se misturam fortemente elementos novos ("as novas ameaças", como o tráfico de drogas e fatores clássicos.This article works the thesis that the security agenda of the USA for Colombia, that acquires a concrete expression in mechanisms like the Colombia Plan and the Andean Regional Initiative, will remain as the central axis of the security policy in the South-American region. However, the notion of security that the decision makers of the USA have in mind in the Colombian case reflects a vision focused on the perceptions of threat in which new elements ("the new threats", such as traffic, and classical factors are mixed.

  7. The Boston keratoprosthesis in the management of corneal limbal stem cell deficiency.

    Science.gov (United States)

    Sejpal, Kunjal; Yu, Fei; Aldave, Anthony J

    2011-11-01

    To report the outcomes of the Boston type I keratoprosthesis (Massachusetts Eye and Ear Infirmary, Boston, MA) in the management of corneal limbal stem cell deficiency (LSCD). A retrospective review of all cases of keratoprosthesis implantation performed by a single surgeon (A.J.A.) between May 1, 2004, and March 31, 2010. Procedures performed for the management of LSCD were identified, and data were collected regarding the patients' ocular history, surgical procedure(s) performed, and postoperative outcomes, including interval visual acuities, retention, complications, and required surgical procedures. The outcome data from patients with LSCD were compared with those of individuals who underwent keratoprosthesis implantation for indications other than LSCD. Twenty-eight keratoprostheses were performed in 23 eyes of 22 patients with LSCD. The most common indications for surgery were chemical injury (7 eyes) and Stevens-Johnson syndrome (6 eyes). Preoperative corrected distance visual acuity (CDVA) was better than counting fingers in 4% of eyes with LSCD and in 9% of eyes without LSCD. Postoperative CDVA was 20/50 or better in 69%, 88%, and 67% of eyes with LSCD at 1, 2, and 3 years after keratoprosthesis implantation, respectively. Each of these percentages is higher than the percentage of eyes without LSCD obtaining CDVA of 20/50 or better at each time point. Whereas the retention failure rate in eyes with LSCD (0.148/eye-year) was higher than the rate in eyes without LSCD (0.114/eye-year), when eyes with Stevens-Johnson syndrome were excluded from the LSCD group, the non-Stevens-Johnson syndrome LSCD retention failure rate (0.056/eye-year) was half that of the non-LSCD group. The most common postoperative complications in eyes with LSCD were persistent corneal epithelial defect (PED) formation (56.5% of eyes) and sterile corneal necrosis (30%), whereas retroprosthetic membrane formation (46%) was the most common postoperative complication in eyes without LSCD

  8. Complicated and messy politics of inclusion: Michfest and the Boston Dyke March.

    Science.gov (United States)

    Trigilio, Jo

    2016-01-01

    To illustrate the challenge of political organizing that grapples with identity politics and inclusion, I focus on two women-centered annual events with very different politics of inclusion: the Michigan Womyn's Music Festival and the Boston Dyke March. (1) arguments made by marginalized people for inclusion into established oppressed identity groups must be constructed with due care to avoid further marginalizing yet other liminal identities; (2) protesting/boycotting other oppressed groups for the purpose of achieving inclusion is often a problematic strategy; (3) the most effective strategy for honoring all people is to support organizations committed to the ideal of inclusion.

  9. The air quality impacts of road closures associated with the 2004 Democratic National Convention in Boston

    Directory of Open Access Journals (Sweden)

    Clougherty Jane E

    2006-05-01

    Full Text Available Abstract Background The Democratic National Convention (DNC in Boston, Massachusetts in 2004 provided an opportunity to evaluate the impacts of a localized and short-term but potentially significant change in traffic patterns on air quality, and to determine the optimal monitoring approach to address events of this nature. It was anticipated that the road closures associated with the DNC would both influence the overall air pollution level and the distribution of concentrations across the city, through shifts in traffic patterns. Methods To capture these effects, we placed passive nitrogen dioxide badges at 40 sites around metropolitan Boston before, during, and after the DNC, with the goal of capturing the array of hypothesized impacts. In addition, we continuously measured elemental carbon at three sites, and gathered continuous air pollution data from US EPA fixed-site monitors and traffic count data from the Massachusetts Highway Department. Results There were significant reductions in traffic volume on the highway with closures north of Boston, with relatively little change along other highways, indicating a more isolated traffic reduction rather than an across-the-board decrease. For our nitrogen dioxide samples, while there was a relatively small change in mean concentrations, there was significant heterogeneity across sites, which corresponded with our a priori classifications of road segments. The median ratio of nitrogen dioxide concentrations during the DNC relative to non-DNC sampling periods was 0.58 at sites with hypothesized traffic reductions, versus 0.88 for sites with no changes hypothesized and 1.15 for sites with hypothesized traffic increases. Continuous monitors measured slightly lower concentrations of elemental carbon and nitrogen dioxide during road closure periods at monitors proximate to closed highway segments, but not for PM2.5 or further from major highways. Conclusion We conclude that there was a small but

  10. Interactions Between Urban Vegetation and Surface Urban Heat Islands: A Case Study in the Boston Metropolitan Region

    Science.gov (United States)

    Melaas, E. K.; Miller, D. L.; Wang, J.; Friedl, M. A.

    2016-12-01

    Many studies have used thermal data from remote sensing to characterize how land use and surface properties modify the climate of cities. However, relatively few studies have examined the impact of elevated temperature on ecophysiological processes in urban areas. In this paper, we use time series of Landsat data to characterize and quantify how geographic variation in Boston's surface urban heat island (SUHI) affects the growing season of vegetation in and around the city, and explore how the quality and character of vegetation patches in Boston affect local heat island intensity. Results from this analysis show strong coupling between Boston's SUHI and vegetation phenology at the scale of both individual landscape units and for the region as a whole, with significant detectable signatures in both surface temperature and growing season length extending 15 km from Boston's urban core. On average, land surface temperatures were about 7 °C warmer and the growing season was 18-22 days longer in Boston relative to adjacent rural areas. Within Boston's urban core, patterns of temperature and timing of phenology in areas with higher vegetation amounts (e.g., parks) were similar to those in adjacent rural areas, suggesting that vegetation patches provide an important ecosystem service that offsets the urban heat island at local scales. Local relationships between phenology and temperature were affected by the intensity of urban land use surrounding vegetation patches and possibly by the presence of exotic tree species that are common in urban areas. Results from this analysis show how species composition, land cover configuration, and vegetation patch sizes jointly influence the nature and magnitude of coupling between vegetation phenology and SUHIs, and demonstrate that urban vegetation provides a significant ecosystem service in cities by decreasing the local intensity of SUHIs.

  11. [Preliminary study of Boston keratoprosthesis in treatment of severe late stage ocular chemical burns].

    Science.gov (United States)

    Chen, Jia-qi; Zhai, Jia-jie; Gu, Jian-jun; Shao, Ying-feng; Liu, Yong-min; Yuan, Jin; Zhou, Shi-you

    2012-06-01

    To evaluate preliminary clinical outcome of Boston type I keratoprosthesis in ocular chemical burn patients. Six keratoprosthesis were implanted into 6 patients of bilateral blindness. Visual acuity in these patients before the operation was light perception and all of them were unsuitable for standard penetrating corneal transplantation. The causes for corneal opacity were alkali burn in 2, sulfate acid burn in 3 and ethanol injury in 1 patient. Shirmer's test revealed severe dry eye in 3 patients, only one eye had normal lacrimal secretion. All patients were male, with follow-up period ranged from 17 to 26 months (mean 24 months). The postoperative visual acuity ranged from 0.05 to 0.5, 5 of them was better than 0.1. The retention rate within the follow-up period was 100%. Intraocular pressure was in normal limit, no retinal detachment was detected by type B ultrasonic examination. Postoperatively, retro-keratoprosthestic membrane occurred in 2 cases and was treated with YAG laser membranectomy, one eye complicated with elevated intraocular pressure and treated with shunt implantation. The Boston type 1 keratoprosthesis is a viable option for patients with obsolete chemical burns.

  12. CALIBRATION/VALIDATION OF LANDSAT-DERIVED OCEAN COLOUR PRODUCTS IN BOSTON HARBOUR

    Directory of Open Access Journals (Sweden)

    N. Pahlevan

    2016-06-01

    Full Text Available The Landsat data archive provides a unique opportunity to investigate the long-term evolution of coastal ecosystems at fine spatial scales that cannot be resolved by ocean colour (OC satellite sensors. Recognizing Landsat’s limitations in applications over coastal waters, we have launched a series of field campaigns in Boston Harbor and Massachusetts Bay (MA, USA to validate OC products derived from Landsat-8. We will provide a preliminary demonstration on the calibration/validation of the existing OC algorithms (atmospheric correction and in-water optical properties to enhance monitoring efforts in Boston Harbor. To do so, Landsat optical images were first compared against ocean colour products over high-latitude regions. The in situ cruise data, including optical data (remote sensing reflectance and water samples were analyzed to obtain insights into the optical and biogeochemical properties of near-surface waters. Along with the cruise data, three buoys were deployed in three locations across the Harbor to complement our database of concentrations of chlorophyll a, total suspended solids (TSS, and absorption of colour dissolved organic matter (CDOM. The data collected during the first year of the project are used to develop and/or tune OC algorithms. The data will be combined with historic field data to map in-water constituents back to the early 1990’s. This paper presents preliminary analysis of some of the data collected under Landsat-8 overpasses.

  13. Harvey Cushing and the battle of Boston common: military medical preparedness for world war one.

    Science.gov (United States)

    Rutkow, Eric; Rutkow, Ira

    2010-07-01

    To explore the events and people that shaped Harvey Cushing, one of the nation's leading surgeons, into a political actor as he rallied support for the issue of military medical preparedness for World War One. In a little remembered episode of American medical history, for 2 years before the nation's formal entry into World War One in April 1917, Harvey Cushing attempted to garner political and professional support for the idea of military medical preparedness. His efforts, including the proposed construction of a functioning Base Hospital on Boston Common, sparked controversy in a public that was torn between maintaining neutrality and going to war. An analysis of Harvey Cushing's unpublished letters, manuscripts, and papers located at the Yale University School of Medicine, New Haven, CT. While Harvey Cushing's crusade for military medical preparedness failed to win over the local public, it helped convince national military leaders that the civilian medical community was ready to assist in the war. This, in turn, laid the foundation for much of the American medical establishment's success on the battlefields of World War One. The disagreement surrounding the Battle of Boston Common, as Harvey Cushing had labeled the debate, reveals both how, even at the brink of war, ideas formulated on the war front could not be translated to the home front, and how early military medical preparedness, although national in character, was commanded by only a few select voices.

  14. Contact lens fitting and long-term management for the Boston keratoprosthesis.

    Science.gov (United States)

    Nau, Amy C; Drexler, Scott; Dhaliwal, Deepinder K; Mah, Francis; Raju, Leela; Deschler, Emily

    2014-05-01

    To examine the types of contact lenses used as bandage lenses in the postoperative management of patients with Boston type 1 keratoprosthesis (K-Pro). We examined the lens parameters, the number of trial lenses used to achieve successful fit, and lens replacement schedule. The strategies to achieving a successful fit in these complex patients are reviewed. This was a single-center, retrospective chart review of patients who had undergone implantation of the Boston keratoprosthesis in 1 or more eyes from January 2006 to December 2011. Patients included male and female subjects aged 18 years or older who had been fit with bandage contact lenses as part of their postoperative management. Twenty-two eyes of 15 patients met the criteria for this review. The age range was 30 to 90 years. There were eight men and seven women. The average number of lenses to achieve a successful fit varied from 1 to 8, with an average of 2.22 trial lenses used per patient. By 6 months after the surgery, 12 K-Pro eyes showed visual acuity of 20/200 or better, with 7 of those eyes attaining better than 20/80 best-corrected Snellen distance acuity. Our results show that it is often necessary to use custom contact lenses for K-Pro patients. Management of poor tear film quality, protein deposition, inflammation, lens replacement schedule, and antibiotic resistance are related considerations.

  15. The geography of violence, alcohol outlets, and drug arrests in Boston.

    Science.gov (United States)

    Lipton, Robert; Yang, Xiaowen; Braga, Anthony A; Goldstick, Jason; Newton, Manya; Rura, Melissa

    2013-04-01

    We examined the relationship between alcohol outlets, drug markets (approximated by arrests for possession and trafficking), and violence in Boston, Massachusetts, in 2006. We analyzed geographic and environmental versus individual factors related to violence and identified areas high in violent crime. We used data from the Boston Police Department, US Census, and Massachusetts State Alcohol Beverage Control Commission. Spatial modeling was employed at the block group level, and violent crime, alcohol outlets, and drug markets were mapped. Relative to other block groups, block groups in the highest decile of violent crime (n = 55) were found to be poorer (e.g., lower incomes, higher percentages of vacant homes), and they had greater numbers of alcohol outlets and higher drug arrest rates. Alcohol outlets and drug possession and trafficking arrests were predictive of violent crime. Also, spatial effects resulting from neighboring block groups were related to violent crime. Both alcohol outlet density and type were associated with violent crime in a differentiated and complex way. With drug possession and trafficking arrests as a proxy for drug markets, spatial relationships between alcohol outlets and violence were found in addition to typical sociodemographic predictors.

  16. Fungal keratitis with the type 1 Boston keratoprosthesis: early Indian experience.

    Science.gov (United States)

    Jain, Vandana; Mhatre, Kanupriya; Shome, Debraj; Pineda, Roberto

    2012-07-01

    To report 2 cases of fungal keratitis and endophthalmitis in patients with the type 1 Boston keratoprosthesis (KPro) in India. Two patients underwent type 1 Boston KPro with uneventful intraoperative and early postoperative courses. The patients presented with keratitis and endophthalmitis within a few months after surgery. Both patients had soft bandage contact lenses in place and were on maintenance low-dose topical steroids and antibiotic eyedrops. Culture was positive for fungus in both the cases. Despite aggressive antifungal medical therapy and surgical management, one patient's eye was eviscerated and the other lost the potential for any useful vision. Fungal infection after KPro surgery can be devastating, negating the extraordinary visual recovery these patients achieve immediately after surgery. Chronic use of topical corticosteroids and broad-spectrum antibiotic and bandage contact lens, although indispensable, may enhance the risk of fungal infection especially in the endemic areas like India. The decision for KPro in such tropical climatic conditions should therefore be taken with absolute caution and frequent patient follow-up. A prophylactic antifungal regime may be mandatory when this procedure is undertaken in fungal endemic areas to improve outcomes.

  17. Long-term complications associated with glaucoma drainage devices and Boston keratoprosthesis.

    Science.gov (United States)

    Li, Jennifer Y; Greiner, Mark A; Brandt, James D; Lim, Michele C; Mannis, Mark J

    2011-08-01

    To evaluate long-term complications related to glaucoma drainage devices in patients undergoing Boston type 1 keratoprosthesis surgery. Retrospective case series. All patients who underwent Boston type 1 keratoprosthesis surgery at the University of California, Davis, between 2004 and 2010 were included. Preoperative and postoperative data were reviewed. Twenty-five eyes with glaucoma drainage devices were highlighted. Visual acuity and postoperative complications were tracked at postoperative months 1, 3, 6, 9, and 12 and at annual intervals thereafter. Forty eyes of 35 patients were evaluated with an average follow-up of 33.6 months. Conjunctival breakdown occurred in association with 10 glaucoma drainage device implants in 9 eyes. Eleven eyes had glaucoma drainage devices placed before keratoprosthesis surgery, 3 eyes underwent glaucoma drainage device placement at the time of surgery, and 2 eyes had a glaucoma drainage device placed after surgery. All but one of the eroded glaucoma drainage devices were placed before surgery. Associated complications included endophthalmitis, hypotony, and keratoprosthesis extrusion, with 6 glaucoma drainage devices requiring removal. Long-term beset-corrected visual acuity was maintained better in eyes in which glaucoma drainage device erosions did not develop. One of the main challenges with keratoprosthesis surgery is treating concurrent glaucoma. Glaucoma drainage devices have been advocated as a way to address this long-term complication, but this series suggests that glaucoma drainage device-related complications can cause significant vision loss. Copyright © 2011 Elsevier Inc. All rights reserved.

  18. Boston Type 1 Keratoprosthesis Implantation in Traumatic Stem Cell Deficiency and Keratoplasty Rejection

    Directory of Open Access Journals (Sweden)

    Canan Aslı Utine

    2012-01-01

    Full Text Available A 31-year-old male patient was admitted with the complaint of decreased vision in both eyes. He underwent multiple pars plana vitrectomy and silicone oil injection operations due to bilateral retina detachment after rocket projectile explosion in his hands at the age of 15. The right eye was pre-phthisical after choroidal hemorrhage that occurred during combined silicone oil extraction and penetrating keratoplasty. The aphakic and vitrectomized left eye had corneal conjunctivalisation of seven dials, deep and superficial stromal neovascularization and history of immunological graft rejection. As the estimated success rate for repeat penetrating keratoplasty was low, Boston type 1 keratoprosthesis surgery was performed. Postoperatively, visual acuity was 0.2 Snellen lines. Macular scar and optic nerve atrophy limited further visual gain. In this study, we aimed to review the current literature about Boston type keratoprosthesis surgery, which should be evaluated as an alternative when conventional penetrating keratoplasty success is deemed to be low. (Turk J Ophthalmol 2012; 42: 66-71

  19. Ocular surface, fornix, and eyelid rehabilitation in Boston type I keratoprosthesis patients with mucous membrane disease.

    Science.gov (United States)

    Rootman, Dan B; Kim, Michelle J; Aldave, Anthony J; Douglas, Raymond; Hwang, Catherine; Goldberg, Robert

    2015-01-01

    To understand the efficacy of various approaches for ocular surface reconstruction in eyes with implanted Boston Type I keratoprosthesis. All eyes implanted with a Boston Type I keratoprosthesis over a 9-year period by a single surgeon were reviewed. Any case in which mucosal rehabilitation was performed was included in the study sample. The type, number, approach, and outcome for all eyelid and ocular surface procedures were assessed. A total of 22 mucosal surface surgeries were performed before, concurrent with, and after implantation of 11 keratoprostheses and 1 penetrating keratoplasty (after keratoprosthesis removal) in 9 eyes of 9 patients. Most of the ocular surface reconstructive surgeries (81.8%; 18/22) were performed at the time of or following keratoprosthesis implantation, with the most common indication being corneal stromal necrosis (44.4%; 8/18). Free grafting and simple advancement resulted in graft retraction for each case, and pedicle or bucket handle flaps resulted in a stable vascularized graft for half of the cases. Graft retraction occurred in 6 of the 9 eyes in this study, including in all 5 eyes of patients with Stevens Johnsons syndrome (SJS). Free grafting and simple advancement flaps do not appear to be effective for rehabilitation in these eyes. However, even vascularized pedicle and bucket handle flaps retracted 50% of the time. Individuals with SJS were more likely to both require conjunctival rehabilitation after keratoprosthesis surgery and develop graft retraction in the course of management.

  20. Trichosporon asahii keratitis in a patient with a type I Boston keratoprosthesis and contact lens.

    Science.gov (United States)

    Keating, Anne; Pineda, Roberto

    2012-03-01

    The aim of the study was to report a case of Trichosporon asahii in a patient with a type I Boston keratoprosthesis and contact lens with review of the literature. A case report and literature review are provided. A 70-year-old monocular South Asian man with light perception vision and dense corneal scarring from previously failed amniotic membrane grafting and one failed corneal transplant was evaluated for a keratoprosthesis for visual rehabilitation. Three months after undergoing uneventful implantation of a type I Boston keratoprosthesis and placement of a therapeutic contact lens, he was found on routine follow-up to have a corneal infiltrate that was culture positive for T. asahii. The fungal keratitis was successfully treated with topical amphotericin B and oral ketoconazole. Contact lens wear is a known risk factor for fungal keratitis. Trichosporon is an uncommon agent of fungal keratitis. We report the first known case of fungal keratitis caused by T.asahii in a patient with a keratoprosthesis and contact lens.

  1. Visual Acuity Outcomes of the Boston Keratoprosthesis Type 1: Multicenter Study Results.

    Science.gov (United States)

    Rudnisky, Christopher J; Belin, Michael W; Guo, Rong; Ciolino, Joseph B

    2016-02-01

    To report logarithm of the minimal angle of resolution (logMAR) visual outcomes of the Boston keratoprosthesis type 1. Prospective cohort study. Preoperative, intraoperative, and postoperative parameters of 300 eyes of 300 patients who underwent implantation of a Boston keratoprosthesis type 1 device between January 2003 and July 2008 by 1 of 19 surgeons at 18 medical centers were collected. After an average of 17.1 ± 14.8 months, visual acuity improved significantly (P keratoprosthesis type 1 is an effective device for rehabilitation in advanced ocular surface disease, resulting in a significant improvement in visual acuity. Eyes achieved a mean value of 20/150 (0.89 ± 0.64 logMAR units) after 6 months and this was relatively stable thereafter. The best visual prognosis is observed in chemical injury eyes, whereas the worst prognosis is in aniridia, although the latter has limited visual potential. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Schiotz tonometry accurately measures intraocular pressure in Boston type 1 keratoprosthesis eyes.

    Science.gov (United States)

    Estrovich, Igor E; Shen, Chris; Chu, Yvonne; Downs, J Crawford; Gardiner, Stuart; Straiko, Michael; Mansberger, Steven L

    2015-06-01

    To evaluate the location of the eye and tonometry device that provides the most accurate intraocular pressure (IOP) measurements in eyes with Boston type 1 keratoprosthesis. A single surgeon sutured a Boston keratoprosthesis into the central cornea in the usual manner in 5 eyes of deceased donors. Another investigator used a 27-gauge needle, digital manometry, and gravity infusion to set the IOP at levels of 10, 20, 30, and 40 mm Hg in random order. A second investigator masked to the level of IOP used a Schiotz tonometer (Sklar) with a 7.5-g plunger load and a Tono-pen XL tonometer (Medtronic) to determine IOP at the temporal corneoscleral limbus and temporal sclera (3 mm temporal to the corneoscleral limbus). We used generalized estimation equation models to determine an average absolute difference between the tonometer measurements compared with the "gold standard" digital manometric IOP. The Schiotz tonometer had a lower median absolute error compared with the Tono-pen at both temporal sclera (5.4 mm Hg vs. 39.0 mm Hg, P keratoprosthesis.

  3. Ultra high resolution optical coherence tomography in Boston type I keratoprosthesis.

    Science.gov (United States)

    Zarei-Ghanavati, Siamak; Betancurt, Carolina; Mas, Alma Michelle; Wang, Jianhua; Perez, Victor L

    2015-01-01

    To evaluate the anterior keratoprosthesis-cornea interface in eyes with Boston type I keratoprosthesis (Kpro). In a prospective non-interventional study, patients with Boston type I Kpro underwent ultra-high resolution optical coherence tomography (UHR-OCT) evaluation. The images were used to measure and describe characteristics of the anterior keratoprosthesis-cornea interface, epithelial interaction at the keratoprosthesis edge and the keratoprosthesis-cornea interface gap. Ten patients including 4 male and 6 female subjects with different preoperative diagnoses, i.e. 8 multiple corneal graft failures and 2 immunological ocular surface diseases, were studied. Mean age was 62.1 ± 20.0 (range, 33.0-83.0) years and mean interval between surgery and UHR-OCT evaluation was 15.2 ± 11.09 months. In eight patients, 360° epithelial growth over the peripheral edge of the Kpro was documented. We detected keratoprosthesis-cornea interface gap in three patients. One subject had developed postoperative endophthalmitis 8 months after surgery and the other two cases were among the high risk group according to the preoperative diagnosis. In one patient with severe ocular hypotony, the Kpro edge was inserted into the anterior stroma and covered with epithelium. UHR-OCT showed that corneal epithelium covers the Kpro edge and seals the potential space between the Kpro and cornea in 80% of cases. The presence of a gap in the interface and lack of epithelial sealing around the Kpro edge might be associated with endophthalmitis.

  4. Delayed Boston Keratoprosthesis Exchange due to a Preceding Vitreoretinal Surgery with Intraoperative Choroidal Detachment.

    Science.gov (United States)

    Relimpio López, María Isabel; Gessa Sorroche, María; Garrido Hermosilla, Antonio Manuel; Laborda Guirao, Teresa; Espejo Arjona, Francisco; Rodríguez de la Rúa Franch, Enrique

    2016-01-01

    The aim is to describe the main characteristics of an anterior/posterior segment surgery and how to resolve intraoperative complications. Setting/Venue: The anterior and posterior segment surgical video was created at the Department of Ophthalmology, Virgin Macarena University Hospital, Seville, Spain. We present the case of a male with Stevens-Johnson syndrome and severe limbal deficiency who needed a Boston type 1 keratoprosthesis, reaching a visual acuity of 0.4 (0.05 before surgery). In the course of follow-up, he developed corneal melting with perforation, immune vitritis, and a large epimacular membrane. We decided to perform a 23-gauge vitrectomy associated with keratoprosthesis exchange. As a consequence of inappropriate anesthesia, the patient woke up during the surgery, provoking a retinal tear besides a choroidal detachment. These damages needed endolaser photocoagulation as well as silicone oil tamponade, forcing us to postpone the exchange. An intravitreal dexamethasone implant was also injected. Two months later, the silicone oil was removed, and the Boston keratoprosthesis was replaced by a new type 1 model with a titanium back plate, which likely improves biocompatibility and retention and may reduce complications such as retroprosthetic membranes and stromal corneal melts. Good anatomical results were achieved, and visual acuity slightly improved to 0.2. Combined anterior and posterior segment surgery represents a great challenge that can improve not only visual acuity but also quality of life in patients with severe diseases such as Stevens-Johnson syndrome. © 2015 S. Karger AG, Basel.

  5. Periprosthetic Tissue Loss in Patients With Idiopathic Vitreous Inflammation After the Boston Keratoprosthesis.

    Science.gov (United States)

    Grassi, Christina M; Cruzat, Andrea; Taniguchi, Elise V; Crnej, Alja; Colby, Kathryn A; Dohlman, Claes H; Chodosh, James

    2015-11-01

    Idiopathic vitritis is a poorly understood complication after Boston keratoprosthesis surgery with unclear etiology. We sought to determine whether an association exists between periprosthetic corneal tissue loss and the development of idiopathic vitritis in keratoprosthesis recipients. Thirteen Boston type I keratoprosthesis recipient eyes with a history of idiopathic vitritis and 34 type I keratoprosthesis recipient eyes with no history of idiopathic vitritis underwent anterior segment optical coherence tomography (AS-OCT) at a median time postoperatively of 2.4 years versus 1.9 years (range, 0.5-14.2 vs. 0.1-13.6 years), respectively. Areas of corneal graft tissue loss ("gaps") around the keratoprosthesis stem were identified and analyzed by 2 masked observers. The difference in the presence, number, and size of gaps was compared between cases and controls. A periprosthetic gap was identified more commonly in idiopathic vitritis cases than in controls on AS-OCT (11/13, 86% vs. 11/34, 33.3%, P keratoprosthesis recipient eyes with idiopathic vitritis had corneal tissue loss around the keratoprosthesis stem than did controls. Tissue loss could serve as an entry point for debris or bacterial components, triggering idiopathic vitritis. Our study underscores the utility of AS-OCT imaging in the postoperative management of keratoprosthesis patients.

  6. Reliability and Validation of the Greek Version of the Boston Carpal Tunnel Questionnaire.

    Science.gov (United States)

    Bougea, Anastasia; Zambelis, Thomas; Voskou, Panagiota; Katsika, Paraskevi Zacharoula; Tzavara, Chara; Kokotis, Panagiotis; Karandreas, Nikolaos

    2017-08-01

    The Boston Carpal Tunnel Questionnaire (BCTQ) is an easy, brief, self-administered questionnaire developed by Levine et al for the assessment of severity of symptoms and functional status of patients with carpal tunnel syndrome. The aim of our study was to develop and validate the Greek version of BCTQ. We conducted a cross-sectional study of 90 patients with idiopathic carpal tunnel syndrome. The original English version of BCTQ was adapted into Greek using forward and backward translation. Reliability was assessed by internal consistency (Cronbach α and item-total correlation) and reproducibility. Validity was examined by correlating the Boston Questionnaire scores to Canterbury severity scale for electrodiagnostic severity grading. The Greek version showed high reliability (Cronbach α 0.89 for Symptom Severity Scale and 0.93 for Functional Status Scale) and construct validity (Pearson correlation coefficient 0.53 for Symptom Severity Scale and 0.68 for Functional Status Scale). Test-retest were 0.75 for Symptom Severity Scale and 0.79 for Functional Status Scale ( P Greek version of the BCTQ is a valid, reliable screening tool for assessment in daily practice of symptoms and functional status in patients with carpal tunnel syndrome.

  7. Methane emissions from natural gas infrastructure and use in the urban region of Boston, Massachusetts.

    Science.gov (United States)

    McKain, Kathryn; Down, Adrian; Raciti, Steve M; Budney, John; Hutyra, Lucy R; Floerchinger, Cody; Herndon, Scott C; Nehrkorn, Thomas; Zahniser, Mark S; Jackson, Robert B; Phillips, Nathan; Wofsy, Steven C

    2015-02-17

    Methane emissions from natural gas delivery and end use must be quantified to evaluate the environmental impacts of natural gas and to develop and assess the efficacy of emission reduction strategies. We report natural gas emission rates for 1 y in the urban region of Boston, using a comprehensive atmospheric measurement and modeling framework. Continuous methane observations from four stations are combined with a high-resolution transport model to quantify the regional average emission flux, 18.5 ± 3.7 (95% confidence interval) g CH4 ⋅ m(-2) ⋅ y(-1). Simultaneous observations of atmospheric ethane, compared with the ethane-to-methane ratio in the pipeline gas delivered to the region, demonstrate that natural gas accounted for ∼ 60-100% of methane emissions, depending on season. Using government statistics and geospatial data on natural gas use, we find the average fractional loss rate to the atmosphere from all downstream components of the natural gas system, including transmission, distribution, and end use, was 2.7 ± 0.6% in the Boston urban region, with little seasonal variability. This fraction is notably higher than the 1.1% implied by the most closely comparable emission inventory.

  8. Self-reported illness among Boston-area international travelers: A prospective study

    Science.gov (United States)

    Chen, Lin H.; Han, Pauline V.; Wilson, Mary E.; Stoney, Rhett J.; Jentes, Emily S.; Benoit, Christine; Ooi, Winnie W.; Barnett, Elizabeth D.; Hamer, Davidson H.

    2017-01-01

    Summary Background The Boston Area Travel Medicine Network surveyed travelers on travel-related health problems. Methods Travelers were recruited 2009–2011 during pre-travel consultation at three clinics. The investigation included pre-travel data, weekly during-travel diaries, and a post-travel questionnaire. We analyzed demographics, trip characteristics, health problems experienced, and assessed the relationship between influenza vaccination, influenza prevention advice, and respiratory symptoms. Results Of 987 enrolled travelers, 628 (64%) completed all surveys, of which 400 (64%) reported health problems during and/or after travel; median trip duration was 12 days. Diarrhea affected the most people during travel (172) while runny/stuffy nose affected the most people after travel (95). Of those with health problems during travel, 25% stopped or altered plans; 1% were hospitalized. After travel, 21% stopped planned activities, 23% sought physician or other health advice; one traveler was hospitalized. Travelers who received influenza vaccination and influenza prevention advice had lower rates of respiratory symptoms than those that received influenza prevention advice alone (18% vs 28%, P = 0.03). Conclusions A large proportion of Boston-area travelers reported health problems despite pre-travel consultation, resulting in inconveniences. The combination of influenza prevention advice and influenza immunization was associated with fewer respiratory symptoms than those who received influenza prevention advice alone. PMID:27687076

  9. Imaging of abdominal and pelvic injuries from the Boston Marathon bombing.

    Science.gov (United States)

    Singh, Ajay K; Sodickson, Aaron; Abujudeh, Hani

    2016-02-01

    The aim of this study is to describe the imaging findings of abdominal and pelvic injuries in victims of the Boston Marathon bombing. A retrospective review of 87 patients following the Boston Marathon bombing was performed to evaluate for abdominal and pelvic injuries on plain radiography or CT scans of the abdomen and pelvis. Imaging exams were evaluated for shrapnel, soft tissue injury, visceral damage, vascular disruption, and fractures. The injuries were classified as primary, secondary, tertiary, and quaternary blast injuries. Eleven of the 87 patients had positive findings in the abdomen or pelvis (M:F = 7:4, average age 34.6 years). There were 22 ball bearings, two nails, one screw, and two irregular metal fragments in the 11 patients with secondary blast (shrapnel) injuries. There was no peritoneal penetration or visceral injury seen in any of the patients. One patient had multiple transverse process fractures, representing tertiary blast injury. All but one patient had superficial penetrating abdominal or pelvic injuries secondary to shrapnel. There were no cases of bowel or solid visceral organ injuries due to the lack of peritoneal violation from the relatively low-powered explosions. Absence of peritoneal penetration by shrapnel indicates no need for laparotomy following low-powered explosions.

  10. Psychiatric advanced practice nurses contributions to supporting survivors and caregivers affected by the Boston marathon bombings.

    Science.gov (United States)

    Lakatos, Barbara E; Delisle, Leslie; Mitchell, Monique; Etheredge, Mary Lou

    2014-01-01

    The role of the psychiatric advanced practice nurse in promoting psychological health and resiliency for patients, their families and staff following the Boston Marathon bombings is reviewed. On April 15, 2013, 2 bombs exploded near the finish line at the Boston Marathon. Within minutes, 39 patients suffering from multiple injuries presented at a level I trauma center. The magnitude of this event and its effect on our hospital required a comprehensive response that would promote resiliency and healing. Lessons shared from responders to other tragedies were helpful in guiding our interprofessional efforts. The multiple layers of our response are reviewed to offer learnings that may inform others as they work to promote resiliency and healing following traumatic events. In response to this event, we utilized a trauma-informed care framework emphasizing physical, psychological, and emotional safety to assist staff, survivors, and families on their journey of healing. Emotional reactions were dramatic but were eased by the psychological care and education that our patients, their families, and staff received in the first days to weeks after the bombings. The psychiatric advanced practice nurse can influence positive outcomes by utilizing a trauma-informed care framework.

  11. Radiologic features of injuries from the Boston Marathon bombing at three hospitals.

    Science.gov (United States)

    Singh, Ajay K; Goralnick, Eric; Velmahos, George; Biddinger, Paul D; Gates, Jonathan; Sodickson, Aaron

    2014-08-01

    The aim of this study is to describe the radiologic imaging findings of primary, secondary, tertiary, and quaternary blast injuries in patients injured in the Boston Marathon bombing on April 15, 2013. A total of 43 patients presenting to three acute care hospitals and undergoing radiologic investigation within 7 hours of the time of the bombing on April 15, 2013, were included in this study. The radiographic and CT features of these patients were evaluated for imaging findings consistent with primary, secondary, tertiary, and quaternary blast injury. There were no pulmonary or gastrointestinal manifestations of the primary blast wave on imaging. Secondary blast injuries identified on imaging included a total of 189 shrapnel fragments identified in 32 of the 43 patients. The shrapnel was identified most often in the soft tissues of the leg (36.5%), thigh (31.2%), and pelvis (13.2%). Imaging identified 125 ball bearings, 10 nails, one screw, 44 metal fragments, and nine other (gravel, glass, etc.) foreign bodies. Injuries from the Boston Marathon bombing were predominantly from the secondary blast wave and resulted in traumatic injuries predominantly of the lower extremities. The most common shrapnel found on radiologic evaluation was the ball bearing.

  12. Psychological effects of the marathon bombing on Boston-area veterans with posttraumatic stress disorder.

    Science.gov (United States)

    Miller, Mark W; Wolf, Erika J; Hein, Christina; Prince, Lauren; Reardon, Annemarie F

    2013-12-01

    This study examined the psychological impact of the Boston Marathon bombing using data from an ongoing longitudinal study of Boston-area veterans with posttraumatic stress disorder (PTSD; N = 71). Participants were assessed by telephone within 1 week of the end of the event; 42.3% of participants reported being personally affected by the bombings and/or the manhunt that followed. The majority of them reported that the bombing reminded them of their own traumas and/or caused other emotional distress. Examination of change in posttraumatic stress disorder (PTSD) symptoms from a prebombing assessment an average of 2 months earlier to 1 week after the event revealed no significant change in symptoms across the sample as a whole. However, examination of patterns of change at the individual level revealed significant correlations (r = .33; p = .005) between distress at the time of the event and change in total PTSD symptom severity, with this effect accounted for primarily by increases in intrusion and avoidance symptoms (rs = .35 and .31, ps = .002 and .008, respectively). Findings of this study should raise awareness of the potential impact of terror attacks, mass shootings, and other events of this type on the well-being of individuals with histories of trauma and/or pre-existing PTSD. Published 2013. This article is a US Government work and is in the public domain in the USA.

  13. The initial response to the Boston marathon bombing: lessons learned to prepare for the next disaster.

    Science.gov (United States)

    Gates, Jonathan D; Arabian, Sandra; Biddinger, Paul; Blansfield, Joe; Burke, Peter; Chung, Sarita; Fischer, Jonathan; Friedman, Franklin; Gervasini, Alice; Goralnick, Eric; Gupta, Alok; Larentzakis, Andreas; McMahon, Maria; Mella, Juan; Michaud, Yvonne; Mooney, David; Rabinovici, Reuven; Sweet, Darlene; Ulrich, Andrew; Velmahos, George; Weber, Cheryl; Yaffe, Michael B

    2014-12-01

    We discuss the strengths of the medical response to the Boston Marathon bombings that led to the excellent outcomes. Potential shortcomings were recognized, and lessons learned will provide a foundation for further improvements applicable to all institutions. Multiple casualty incidents from natural or man-made incidents remain a constant global threat. Adequate preparation and the appropriate alignment of resources with immediate needs remain the key to optimal outcomes. A collaborative effort among Boston's trauma centers (2 level I adult, 3 combined level I adult/pediatric, 1 freestanding level I pediatric) examined the details and outcomes of the initial response. Each center entered its respective data into a central database (REDCap), and the data were analyzed to determine various prehospital and early in-hospital clinical and logistical parameters that collectively define the citywide medical response to the terrorist attack. A total of 281 people were injured, and 127 patients received care at the participating trauma centers on that day. There were 3 (1%) immediate fatalities at the scene and no in-hospital mortality. A majority of the patients admitted (66.6%) suffered lower extremity soft tissue and bony injuries, and 31 had evidence for exsanguinating hemorrhage, with field tourniquets in place in 26 patients. Of the 75 patients admitted, 54 underwent urgent surgical intervention and 12 (22%) underwent amputation of a lower extremity. Adequate preparation, rapid logistical response, short transport times, immediate access to operating rooms, methodical multidisciplinary care delivery, and good fortune contributed to excellent outcomes.

  14. Media Use and Exposure to Graphic Content in the Week Following the Boston Marathon Bombings.

    Science.gov (United States)

    Jones, Nickolas M; Garfin, Dana Rose; Holman, E Alison; Silver, Roxane Cohen

    2016-09-01

    Traditional and new media inform and expose the public to potentially distressing graphic content following disasters, but predictors of media use have received limited attention. We examine media-use patterns after the Boston Marathon bombings (BMB) in a representative national U.S. sample (n = 2888), with representative oversamples from metropolitan Boston (n = 845) and New York City (n = 941). Respondents completed an Internet-based survey 2-4 weeks post-BMB. Use of traditional media was correlated with older age, prior indirect media-based exposure to collective traumas, and direct BMB exposure. New media use was correlated with younger age and prior direct exposure to collective traumas. Increased television and online news viewing were associated with exposure to more graphic content. The relationship between traditional and new media was stronger for young adults than all other age groups. We offer insights about the relationship between prior collective trauma exposures and media use following subsequent disasters and identify media sources likely to expose people to graphic content. © Society for Community Research and Action 2016.

  15. Environmental permit tracking and compliance: Central Artery/Tunnel Project, Boston, MA

    Energy Technology Data Exchange (ETDEWEB)

    Forbush, L. (BSC Group, Boston, MA (United States))

    1993-01-01

    The Central Artery/Tunnel (CA/T) Project in Boston, Massachusetts involves the replacement of the existing I-93 interstate highway (Central Artery) and the extension of I-90 (Massachusetts Turnpike) to Logan International Airport. To date, approximately 95 environmental and related permits have been obtained for the CA/T Project. At least 200 permits from federal, state and local regulatory agencies will be acquired for the entire Project. The proposed action includes construction activities and permanent structures related to the crossing of three bodies of water: Charles River, Fort Point Channel, and Boston Inner Harbor. The Project also includes work in Massachusetts filled tidelands, relocation or construction of outfalls, disposition of construction dewatering and tunnel drainage fluids, and capping of an abandoned landfill. The number of permits, interrelationships between permits and interfaces with design and construction schedules have necessitated the development and implementation of a permit tracking system. The system tracks permit applications from preparation through public and agency review to permit issuance. The issues are discussed in detail: Phased development of the tracking system; Utilization of Project standard scheduling system software, Primavera Project Planner; How the information generated by the tracking system is used at the Project; Report format and production; Construction phase services and the multidiscipline, integrated Project schedule.

  16. "We make the path by walking it": building an academic community partnership with Boston Chinatown.

    Science.gov (United States)

    Rubin, Carolyn Leung; Allukian, Nathan; Wang, Xingyue; Ghosh, Sujata; Huang, Chien-Chi; Wang, Jacy; Brugge, Doug; Wong, John B; Mark, Shirley; Dong, Sherry; Koch-Weser, Susan; Parsons, Susan K; Leslie, Laurel K; Freund, Karen M

    2014-01-01

    The potential for academic community partnerships are challenged in places where there is a history of conflict and mistrust. Addressing Disparities in Asian Populations through Translational Research (ADAPT) represents an academic community partnership between researchers and clinicians from Tufts Medical Center and Tufts University and community partners from Boston Chinatown. Based in principles of community-based participatory research and partnership research, this partnership is seeking to build a trusting relationship between Tufts and Boston Chinatown. This case study aims to provides a narrative story of the development and formation of ADAPT as well as discuss challenges to its future viability. Using case study research tools, this study draws upon a variety of data sources including interviews, program evaluation data and documents. Several contextual factors laid the foundation for ADAPT. Weaving these factors together helped to create synergy and led to ADAPT's formation. In its first year, ADAPT has conducted formative research, piloted an educational program for community partners and held stakeholder forums to build a broad base of support. ADAPT recognizes that long term sustainability requires bringing multiple stakeholders to the table even before a funding opportunity is released and attempting to build a diversified funding base.

  17. Innovations in nutrition education and global health: the Bangalore Boston nutrition collaborative

    Science.gov (United States)

    2014-01-01

    Background India has a wide range of nutrition and health problems which require professionals with appropriate skills, knowledge and trans-disciplinary collaborative abilities to influence policy making at the national and global level. Methods The Bangalore Boston Nutrition Collaborative (BBNC) was established as collaboration between St. John’s Research Institute (SJRI), Harvard School of Public Health and Tufts University, with a focus on nutrition research and training. The goals of the BBNC were to conduct an interdisciplinary course, develop web-based courses and identify promising Indian students and junior faculty for graduate training in Boston. Results From 2010, an annual two-week short course in nutrition research methods was conducted on the SJRI campus taught by international faculty from Indian and US universities. More than 100 students applied yearly for approximately 30 positions. The course had didactic lectures in the morning and practical hands-on sessions in the afternoon. Student rating of the course was excellent and consistent across the years. The ratings on the design and conduct of the course significantly improved (p nutrition and global health. Efforts are ongoing to secure long term funding to sustain and expand this collaboration to deliver high quality nutrition and global health education enabled by information and communication technologies. PMID:24400811

  18. Individual Well-Being and the Allocation of Time Before and After the Boston Marathon Terrorist Bombing

    OpenAIRE

    Clark, Andrew E.; Stancanelli, Elena G. F.

    2016-01-01

    There is a small literature on the economic costs of terrorism. We consider the effects of the Boston marathon bombing on Americans’ well-being and time allocation. We exploit data from the American Time Use Survey and Well-Being Module in the days around the terrorist attack to implement a regression-discontinuity design. The bombing led to a significant and large drop of about 1.5 points in well-being, on a scale of one to six, for residents of the States close to Boston. The happiness of A...

  19. Heavy metals in geochemical sediment fractions of the border region between Baja California, Mexico, and California, USA; Metales pesados en fracciones geoquimicas de sedimentos de la region fronteriza de Baja California, Mexico, y California, EUA

    Energy Technology Data Exchange (ETDEWEB)

    Villaescusa-Celaya, Julio A; Gutierrez-Galindo, Efrain A; Flores-Munoz, Gilberto [Instituto de Investigaciones Oceanologicas, Universidad Autonoma de Baja California, Ensenada, B.C., (Mexico)

    1997-03-01

    water in the coastal zone are being transported outside the region. [Spanish] En este estudio se evalua la concentracion de los metales pesados Cu, Zn, Ni, Cr, Pb, Cd, Ag, Mn y Fe en las diferentes fracciones geoquimicas del sedimento, como una medida para conocer el impacto de las descargas de agua residuales sobre los sedimentos costeros de la region. Para este proposito, durante un crucero oceanografico realizado en abril de 1992 (ECOBAC IV), se recolectaron 20 muestras de sedimento superficial en la plataforma costera de la region fronteriza de Baja California (Mexico) y California (EUA). Las muestras de sedimento se sometieron a un procedimiento de extraccion secuencial, disenado para obtener las fracciones geoquimicas operacionalmente definidas como: intercambiable (F1), carbonatos (F2), oxihidroxidos de Fe y Mn (F3), materia organica/sulfuros (F4) y residual o litogenica (F5). La especiacion operacional de los metales indica que las principales fases que acumulan metales en el sedimento son la matriz detrital o litogenica, los oxihidroxidos de Fe y Mn y la materia organica/sulfuros, en este orden. La distribucion espacial de los metales pesados en la fase reactiva (definida como la suma de F1-F4) presento, en general, una tendencia a aumentar en concentracion en sedimentos alejados de la costa. Los metales pesados en la fase reactiva aparentemente son controlados por la concentracion de hierro reactivo en los sedimentos, con excepcion del Pb, el Cd y la Ag. Esto sugiere que estos ultimos elementos son controlados por otros procesos, tales como el material particulado de origen biogenico. En contraste, la distribucion espacial de los metales pesados en la fase detrital presento un comportamiento inverso, esto es, las mayores concentraciones de metales se encuentran cercanas a la costa frente a la planta de tratamiento de aguas residuales de Punta Bandera, Baja California. Las concentraciones promedio de metales totales (suma de F1-F5) fueron de 7.6, 40, 21, 68

  20. Efeitos do controle glicêmico obtido em curto prazo sobre a microalbuminúria e a filtração glomerular em pacientes diabéticos do tipo 2 com controle glicêmico precário

    Directory of Open Access Journals (Sweden)

    Clarissa Baia Bargas Uezima

    2012-06-01

    Full Text Available INTRODUÇÃO: O controle intensivo da glicemia reduz significativamente o risco de desenvolvimento de complicações microvasculares, incluindo a nefropatia. OBJETIVOS: Foi avaliado o impacto do controle glicêmico, por meio do cálculo da glicemia média semanal (GMS e variabilidade glicêmica (VG, sobre a pressão arterial (PA nas 24 horas (MAPA, excreção urinária de albumina (EUA e taxa de filtração glomerular (TFG. MÉTODOS: 53 pacientes com diabetes mellitus tipo 2 (DM2, dividida aleatoriamente em dois grupos para receber tratamento convencional ou intensivo. Esse último incluía visitas semanais para ajustes da medicação e aplicação de um plano educacional durante seis semanas. RESULTADOS: Observou-se controle glicêmico (GMS 120 mmHg e que se reduziu de 138,4 ± 10,1 para 127,8 ± 11,6 mmHg (p = 0,023 ao final das seis semanas. Foram observadas reduções da PAS e PA diastólica (PAD na vigília e durante o sono, que não ocorreram no grupo (n = 17 sem controle glicêmico e PAS >120 mmHg. Inicialmente, 15 pacientes apresentavam TFG >120 mL/min, sendo que após seis semanas, apenas o subgrupo que alcançou controle glicêmico (n = 7 mostrou redução de 137,2 ± 16 para 122,2 ± 25,2 mL/min (p = 0,02. No inicio do estudo, outros quinze pacientes apresentavam microalbuminúria. Após seis semanas, independente de terem alcançado o controle glicêmico preconizado, observou-se redução da EUA de 63,0 ± 43,1 para 24,8 ± 19,5 mg/g de creatinina (p = 0,02. CONCLUSÃO: Assim, o controle glicêmico obtido em curto prazo resultou na redução da PA, da TFG e da EUA nos pacientes com DM2 que apresentavam alterações desses parâmetros, alterações benéficas no que se refere à proteção renal.

  1. Long-term results after Boston brace treatment in adolescent idiopathic scoliosis

    Directory of Open Access Journals (Sweden)

    Steen Harald

    2009-08-01

    Full Text Available Abstract Background Few studies have evaluated long-term outcome after bracing using validated health related quality of life outcome measures. The aim of the present study was to evaluate the long-term outcome in adolescent idiopathic scoliosis (AIS 12 years or more after treatment with the Boston brace. Methods 109 (80% of 135 patients (7 men with AIS treated with the Boston brace at a mean of 19.2 (range 12–28 years previously responded to long-term follow-up examination. All patients (n = 109 answered a standardised questionnaire including demographics, work status, treatment, Global Back Disability Question, Oswestry Disability Index (ODI (100-worst possible, General Function Score (GFS (100 – worst possible, EuroQol (EQ-5D (1 – best possible, EQ-VAS (100 – best possible and Scoliosis Research Society -22 (SRS – 22 (5 – best possible. Clinical and radiological examination was obtained in 86 patients. Results The magnitude of the primary prebrace major curve was in average 33.4° (range 20 – 52. At weaning and at the last follow-up the corresponding values were 28.3° (9–56 and 34.2° (8 – 87, respectively. The mean age at follow-up was 35 (27 – 46 years. Work status was: full time (80%, on sick-leave (3%, on rehabilitation (4%, disability pension (4%, homemaker (7%, students (2%, 7% had changed their job because of back pain. 88% had had delivered a baby, 55% of them had pain in pregnancy. Global back status was excellent or good in 81%. The mean (standard deviation ODI was 6.4 (9.8, GFS 5.4 (10.5, EQ-5D 0.84 (0.2, SRS-22: pain 4.2 (0.8, mental health 4.2 (0.7, self-image 3.9 (0.7, function 4.1 (0.6, satisfaction with treatment 3.7 (1.0. 28% had taken physiotherapy for back pain the last year and 12% had visited a doctor. Conclusion Long-term results were satisfactory in most patients with AIS treated with the Boston brace.

  2. 77 FR 16849 - Notice of Realignment/Merger of Five Regional Audit Offices: Boston, MA Will Merge With New York...

    Science.gov (United States)

    2012-03-22

    ... URBAN DEVELOPMENT Notice of Realignment/Merger of Five Regional Audit Offices: Boston, MA Will Merge With New York, NY; and the Gulf Coast Region Will Merge With Atlanta, GA and Fort Worth, TX AGENCY...) will merge with New York, New York (Region 2); and The Gulf Coast Region (Region 11) will merge with...

  3. "We Are Not Terrorists," but More Likely Transnationals: Reframing Understandings about Immigrants in Light of the Boston Marathon Bombings

    Science.gov (United States)

    Kasun, G. Sue

    2013-01-01

    The Boston Marathon bombings in April 2013 created a new kind of discomfort in the United States about "self-radicalized" terrorists, particularly related to Muslim immigrants. The two suspected bombers, brothers with Chechen backgrounds, had attended U.S. public schools. News media portrayed the brothers as "immigrants" and…

  4. Epithelial growth over the optic surface of the type 1 Boston Keratoprosthesis: histopathology and implications for biointegration

    Science.gov (United States)

    Khalifa, Yousuf M; Davis, Don; Mamalis, Nick; Moshirfar, Majid

    2010-01-01

    We report the histopathology of epithelial overgrowth in the Boston type I keratoprosthesis. The epithelium shows an inconsistent number of layers and basement membrane and goblet cells are absent. Epithelialization of the keratoprosthesis optic would have multiple advantages, but the limitation of vision makes tolerating the overgrowth difficult. PMID:20957142

  5. Individual-tree basal area growth, survival, and total height models for upland hardwoods in the Boston Mountains of Arkansa

    Science.gov (United States)

    Paul A. Murphy; David L. Graney

    1988-01-01

    Models were developed for individual-tree basal area growth, survival, and total heights for different species of upland hardwoods in the Boston Mountains of north Arkansas. Data used were from 87 permanent plots located in an array of different sites and stand ages; the plots were thinned to different stocking levels and included unthinned controls. To test these...

  6. Expanding What It Means to Make Evidence-Based Claims: Online Comments and the Boston Marathon Bombings

    Science.gov (United States)

    Chandler-Olcott, Kelly

    2014-01-01

    This article argues that exploration of media coverage of a story like the Boston Marathon bombings, including online comments posted by readers, can support youth in reflecting on and thinking critically about a tragedy while offering opportunities for literacy pedagogy consistent with the goals of the Common Core State Standards for English…

  7. Surgical and visual outcomes of the type I Boston Keratoprosthesis for the management of aniridic fibrosis syndrome in congenital aniridia.

    Science.gov (United States)

    Bakhtiari, Pejman; Chan, Clara; Welder, Jeffrey D; de la Cruz, Jose; Holland, Edward J; Djalilian, Ali R

    2012-05-01

    To report the clinical features and surgical management of aniridic fibrosis syndrome using the type I Boston Keratoprosthesis (KPro). Interventional case series. Retrospective chart review of 9 eyes in 9 patients with congenital aniridia that developed aniridic fibrosis syndrome. All patients had clinical diagnosis of congenital aniridia. Previously, all patients had undergone cataract surgery with posterior chamber intraocular lens (IOL) implantation and 7 patients had existing tube shunts. In all cases, fibrosis presented as progressive retrocorneal and retrolenticular membrane formation causing displacement of the IOL and secondary corneal decompensation. Two eyes had tractional folds in the retina with posterior extension of the membrane. The management included IOL explantation in 7 of 9 cases, removal of fibrosis with pars plana vitrectomy in all 9 patients, and implantation of a type I Boston KPro in all eyes. At a mean final follow-up of 26.1 months (range 6 to 48 months), vision remained improved in all patients. No patient had recurrence of the fibrotic membrane after KPro implantation. This study represents another case series describing aniridic fibrosis syndrome and the largest study to report utilization of the type I Boston KPro in such patients. As the fibrosis can cause IOL dislocation, corneal decompensation, hypotony, and retinal detachment, monitoring for aniridic fibrosis syndrome in congenital aniridia with early surgical intervention is recommended. Type I Boston KPro may be considered in the surgical treatment of this condition. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. Caffeine in Boston Harbor past and present, assessing its utility as a tracer of wastewater contamination in an urban estuary

    Science.gov (United States)

    Sites throughout Boston Harbor were analyzed for caffeine to assess its utility as a tracer in identifying sources of sanitary wastewater. Caffeine ranged from 15 ng/L in the outer harbor to a high of 185 ng/L in the inner harbor. Inner harbor concentrations were a result of comb...

  9. Caffeine in an Urbanized Estuary: Past and Present Influence of Wastewater Effluents in Boston Harbor, MA, USA

    Science.gov (United States)

    Caffeine has been identified by previous research as a potential tracer of sanitary wastewater. To further assess the utility of caffeine as a tracer of wastewater sources, samples from 25 sites throughout Boston Harbor were collected and analyzed for caffeine by LC-MS/MS. Caff...

  10. A vinheta como estratégia de coleta de dados de pesquisa em enfermagem

    Directory of Open Access Journals (Sweden)

    Galante Anderson Cleyton

    2003-01-01

    Full Text Available Com o objetivo de detectar, quantificar e analisar o uso da vinheta como estratégia de coleta de dados, investigou-se, nos sistemas MEDLINE e LILACS, no período de 1966 a 2000, como tem sido utilizada essa estratégia para coletar dados de pesquisa. Foram localizados 582 trabalhos de pesquisa e, desses, 57 (9,8% foram publicados em periódicos de enfermagem ou continham estudos sobre os profissionais e/ou alunos de enfermagem; sendo que 4 (7% foram publicados na década de 80; 49 (86% na de 90 e 4 (7% em 2000. As propostas identificadas nos estudos foram: explorar atitude/comportamento 20 (35,1%; explorar conhecimento/atitude/ comportamento 14 (24,6%; avaliação 12 (21,1%; explorar nível de conhecimento 6 (10,5%; estudo metodológico 3 (5,3% e atribuição de responsabilidade 2 (3,5%. O tema prevalente foi assistência de enfermagem. Os EUA apresentaram 34 (59,6% publicações e o Reino Unido 16 (28,1%. Foi encontrado um trabalho realizado na América Latina.

  11. Sediment toxicity in Boston Harbor: Magnitude, extent, and relationships with chemical toxicants. Technical memo

    Energy Technology Data Exchange (ETDEWEB)

    Long, E.R.; Sloane, G.M.; Carr, R.S.; Scott, K.J.; Thursby, G.B.

    1996-06-01

    A survey of the toxicity of sediments throughout Boston Harbor and vicinity was conducted by NOAA`s National Status and Trends (NS&T) Program. The objectives of the survey were to determine the magnitude and spatial extent of toxicity and the relationship between measures of toxicity and the concentrations of chemical toxicants in the sediments. Multiple toxicity tests were performed including: an amphipod survival test performed with whole sediments, a microbial bioluminescence test performed with organic solvent extracts of the sediments, and sea urchin fertilization and embryological development tests performed with the pore waters extracted from the sediments. Chemical analyses were performed on selected samples for trace metals, polynuclear aromatic hydrcarbons, chlorinated pesticides, PCBs, and butyltins.

  12. Neighborhood social cohesion and smoking among legal and unauthorized Brazilian migrants in metropolitan Boston.

    Science.gov (United States)

    Holmes, Louisa M; Marcelli, Enrico A

    2014-12-01

    Tobacco smoking is estimated to be the largest preventable cause of mortality in the USA, but little is known about the relationship between neighborhood social environment and current smoking behavior or how this may differ by population and geography. We investigate how neighborhood social cohesion and disorder are associated with smoking behavior among legal and unauthorized Brazilian migrant adults using data from the 2007 Harvard-UMASS Boston Metropolitan Immigrant Health and Legal Status Survey (BM-IHLSS), a probabilistic household survey of adult Brazilian migrants. We employ logistic regression to estimate associations between neighborhood social cohesion, neighborhood disorder, and current smoking. We find that neighborhood-level social cohesion is associated with lower likelihood of being a current smoker (O.R. = .836; p cohesion may be protective against smoking. Alternatively, neighborhood disorder does not appear to be related to current smoking among Brazilian migrants.

  13. The Sociology of the Deceased Harvard Medical Unit at Boston City Hospital.

    Science.gov (United States)

    Tishler, Peter V

    2015-12-01

    Many graduates of the Harvard Medical Unit (HMU) at Boston City Hospital, in either the clinical training/residency program or the research program at the Thorndike Memorial Laboratory, contributed in major ways to the HMU and constantly relived their HMU experiences. The HMU staff physicians, descending from founder and mentor physicians Francis W. Peabody, Soma Weiss, and George R. Minot, were dedicated to the teaching, development, and leadership of its clinical and research trainees, whose confidence and dedication to patient care as a result of their mentorship led many to lifelong achievements as clinicians, teachers, and mentors. Their experience also led to a lifelong love of the HMU (despite its loss), camaraderie, happiness, and intense friendships with their associates.

  14. Low-Cost and Readily Available Tissue Carriers for the Boston Keratoprosthesis: A Review of Possibilities

    Directory of Open Access Journals (Sweden)

    Andrea Cruzat

    2013-01-01

    Full Text Available The Boston keratoprosthesis (B-KPro, currently the most commonly used artificial cornea worldwide, can provide rapid visual rehabilitation for eyes with severe corneal opacities not suitable for standard corneal transplantation. However, the B-KPro presently needs a corneal graft as a tissue carrier. Although corneal allograft tissue is readily available in the United States and other developed countries with established eye banks, the worldwide need vastly exceeds supply. Therefore, a simple, safe, and inexpensive alternative to corneal allografts is desirable for the developing world. We are currently exploring reasonable alternative options such as corneal autografts, xenografts, noncorneal autologous tissues, and laboratory-made tissue constructs, as well as modifications to corneal allografts, such as deep-freezing, glycerol-dehydration, gamma irradiation, and cross-linking. These alternative tissue carriers for the B-KPro are discussed with special regard to safety, practicality, and cost for the developing world.

  15. Streptococcus agalactiae Endophthalmitis in Boston Keratoprosthesis in a Patient with Steven–Johnson Syndrome

    Science.gov (United States)

    Al-Otaibi, Humoud M.; Talea, Mohammed; Kirat, Omar; Stone, Donald U.; May, William N.; Kozak, Igor

    2016-01-01

    A 25-year-old Syrian male with a previous episode of Stevens-Johnson syndrome with bilateral corneal cicatrization previously underwent surgery for Type 1 Boston Keratoprosthesis (K-Pro). Sixteen months after the K-Pro surgery, the patient presented with decreased vision to hand motion and microbial keratitis of the graft around the K-Pro with purulent discharge. Corneal scrapings were nonrevealing. B-scan in 3 days showed increased debris in the vitreous cavity and thickened retinochoroidal layer. Intravitreal tap and injections of vancomycin and ceftazidime were performed. The vitreous culture revealed β-hemolytic Streptococcus agalactiae; fungal cultures were negative. Repeat B-scan 3 days later demonstrated decreased vitreous opacity, and the patient felt more comfortable and was without pain. His visual acuity improved to 20/70, ocular findings have been stable for 9 months, and the patient continues to be monitored. PMID:27994401

  16. Low-Cost and Readily Available Tissue Carriers for the Boston Keratoprosthesis: A Review of Possibilities

    Science.gov (United States)

    Cruzat, Andrea; Paschalis, Eleftherios I.; Pineda, Roberto; Dohlman, Claes H.

    2013-01-01

    The Boston keratoprosthesis (B-KPro), currently the most commonly used artificial cornea worldwide, can provide rapid visual rehabilitation for eyes with severe corneal opacities not suitable for standard corneal transplantation. However, the B-KPro presently needs a corneal graft as a tissue carrier. Although corneal allograft tissue is readily available in the United States and other developed countries with established eye banks, the worldwide need vastly exceeds supply. Therefore, a simple, safe, and inexpensive alternative to corneal allografts is desirable for the developing world. We are currently exploring reasonable alternative options such as corneal autografts, xenografts, noncorneal autologous tissues, and laboratory-made tissue constructs, as well as modifications to corneal allografts, such as deep-freezing, glycerol-dehydration, gamma irradiation, and cross-linking. These alternative tissue carriers for the B-KPro are discussed with special regard to safety, practicality, and cost for the developing world. PMID:24371522

  17. Femtosecond-assisted preparation of donor tissue for Boston type 1 keratoprosthesis

    Directory of Open Access Journals (Sweden)

    Moshirfar M

    2011-07-01

    Full Text Available Majid Moshirfar1, Marcus C Neuffer1, Krista Kinard1, Monette T Lependu1, Shameema Sikder21John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA; 2Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USAAbstract: We describe a technique for femtosecond laser-assisted preparation of donor tissue for Boston type 1 keratoprosthesis to provide accurate double punching of the donor tissue for optimized alignment in the visual axis. The technique was reproducibly performed in four donor corneas mounted in an artificial anterior chamber. This technique can provide optically centered donor tissue with smooth trephinated edges.Keywords: keratoplasty, femtosecond laser, cornea, laser-trephinated tissue

  18. Boston type 1 keratoprosthesis from patient selection through postoperative management: a review for the keratoprosthetic surgeon

    Directory of Open Access Journals (Sweden)

    Williamson SL

    2016-03-01

    Full Text Available Samantha L Williamson,1 M Soledad Cortina2 1Department of Ophthalmology, Kaiser Permanente Mid-Atlantic Medical Group, Baltimore, MD, USA; 2Department of Ophthalmology and Visual Sciences, University of Illinois Eye and Ear Infirmary, Chicago, IL, USA Abstract: For the anterior segment surgeon, the implantation of Boston type 1 keratoprosthesis is a multistep process that begins with careful patient selection. Success depends on thorough preoperative evaluation, detailed surgical planning, and frequent postoperative follow-up. New practice patterns have emerged for each of these phases as the international experience with keratoprosthesis grows. This review details special considerations that can improve outcomes and also allow surgeons to consider its use in challenging patient populations at each step. Keywords: Keratoprosthesis, aniridia, ocular cicatricial pemphigoid, Stevens–Johnson syndrome

  19. Corneal graft dellen in a patient implanted with a Boston keratoprosthesis type 1.

    Science.gov (United States)

    Scotto, Riccardo; Vagge, Aldo; Traverso, Carlo E

    2017-02-01

    The purpose of this study was to report a case of corneal dellen in a patient implanted with a Boston type 1 keratoprosthesis (KPro), which rapidly appeared after the loss of the large-diameter soft contact lens. This study is an observational case report of a 56-year-old man who underwent KPro implantation in his right eye in November 2010. In March 2014 during a follow-up visit, two areas of corneal dellen were observed. The patient had lost his bandage contact lens. With the application of a new soft contact lens, the thinned areas recovered completely within 5 days. After keratoprosthesis implantation, it is necessary to maintain uninterrupted wear of a bandage contact lens as it allows for adequate ocular surface hydration and prevents consequent complications. This case report highlights the need to provide proper instructions to such patients, in order to minimize the risk.

  20. Plastic surgeons and the management of trauma: from the JFK assassination to the Boston Marathon bombing.

    Science.gov (United States)

    Luce, Edward A; Hollier, Larry H; Lin, Samuel J

    2013-11-01

    The fiftieth anniversary of the death by assassination of President John Kennedy is an opportunity to pay homage to his memory and also reflect on the important role plastic surgeons have played in the management of trauma. That reflection included a hypothetical scenario, a discussion of the surgical treatment of Kennedy (if he survived) and Governor Connally. The scenario describes the management of cranioplasty in the presence of scalp soft-tissue contracture, reconstruction of the proximal trachea, reconstitution of the abdominal wall, and restoration of a combined radius and soft-tissue defect. The development of diagnostic and therapeutic advances over the past 50 years in the care of maxillofacial trauma is described, including the evolution of imaging, timing of surgery, and operative techniques. Finally, contemporary measures of triage in situations involving mass casualties, as in the Boston Marathon bombings, complete the dedication to President Kennedy.

  1. Psychiatry department response to the Boston Marathon bombings within a level-1 trauma center.

    Science.gov (United States)

    Oser, Megan; Shah, Sejal B; Gitlin, David

    2015-01-01

    In this article we present how the consultation-liaison and psychology divisions of an academic medical center's Department of Psychiatry responded in the first week after the Boston Marathon bombings, specifically in the context of disaster response guidelines and evidence-based approaches to acute trauma. Since the department had to address several complicated matters at multiple levels within the hospital system, we highlight unexpected issues unique to this particular event as they arose within the primary domains of our involvement. This article aims to (1) provide a descriptive analysis of how we enacted disaster and trauma guidelines and evidence-based care within a hospital setting, (2) shed light on the unique and unexpected administrative and systemic issues encountered in our response, and (3) discuss lessons learned, including opportunities to improve trauma-related care.

  2. Impacts of the Boston prekindergarten program on the school readiness of young children with special needs.

    Science.gov (United States)

    Weiland, Christina

    2016-11-01

    Theory and empirical work suggest inclusion preschool improves the school readiness of young children with special needs, but only 2 studies of the model have used rigorous designs that could identify causality. The present study examined the impacts of the Boston Public prekindergarten program-which combined proven language, literacy, and mathematics curricula with coaching-on the language, literacy, mathematics, executive function, and emotional skills of young children with special needs (N = 242). Children with special needs benefitted from the program in all examined domains. Effects were on par with or surpassed those of their typically developing peers. Results are discussed in the context of their relevance for policy, practice, and theory. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  3. Contact Lens Use in Patients With Boston Keratoprosthesis Type 1: Fitting, Management, and Complications.

    Science.gov (United States)

    Thomas, Merina; Shorter, Ellen; Joslin, Charlotte E; McMahon, Timothy J; Cortina, M Soledad

    2015-11-01

    The Boston type 1 keratoprosthesis (KPro) is the most commonly used artificial cornea worldwide. Long-term bandage contact lenses are the standard of care for patients with these devices. The goal of bandage contact lenses is to maintain hydration and to protect the corneal tissue that surrounds the anterior plate of the keratoprosthesis which is vulnerable to desiccation, epithelial breakdown, dellen formation, and corneal melt. Contact lenses can also improve comfort, correct refractive errors, and improve the cosmesis of patients with artificial corneas. However, the continuous use of contact lenses places these patients at risk for complications such as lens loss, lens deposits, chronic conjunctivitis, and infection. In addition, obtaining an adequate fit in a patient with a compromised ocular surface and history of multiple surgeries including glaucoma drainage devices can present a challenge. This review discusses the types of contact lenses used, special fitting considerations, and common complications in patients with previous KPro surgery.

  4. Long-Term Trends in the Sources of Boston Crime Guns

    Directory of Open Access Journals (Sweden)

    Anthony A. Braga

    2017-10-01

    Full Text Available Analyses of firearm trace data, most collected over relatively brief periods, suggest that a noteworthy share of guns used in crime were recently diverted from legal commerce. This article analyzes a longitudinal database on firearm recoveries by the Boston Police Department between 1981 and 2015 and successfully traced handguns between 1991 and 2015. The percentage of high-capacity semiautomatic pistols among recovered handguns increased dramatically in the 1980s and 1990s. A persistent share of traced handguns were imported from licensed dealers in southern states and an increasing share first purchased at licensed dealers in New Hampshire and Maine. These analyses suggest that market disruption strategies may reduce illegal diversions of new handguns from licensed dealers and the passage of one-handgun-a-month laws may influence where criminals get their guns.

  5. Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health Study

    Directory of Open Access Journals (Sweden)

    Xian-Yong Ma

    2012-01-01

    Full Text Available Brain-derived neurotrophic factor (BDNF has been associated with regulation of body weight and appetite. The goal of this study was to examine the interactions of a functional variant (rs6265 in the BDNF gene with dietary intake for obesity traits in the Boston Puerto Rican Health Study. BDNF rs6265 was genotyped in 1147 Puerto Rican adults and examined for association with obesity-related traits. Men (n=242 with the GG genotype had higher BMI (P=0.009, waist circumference (P=0.002, hip (P=0.002, and weight (P=0.03 than GA or AA carriers (n=94. They had twice the risk of being overweight (BMI≥25 relative to GA or AA carriers (OR = 2.08, CI = 1.02–4.23, and P=0.043. Interactions between rs6265 and polyunsaturated fatty acids (PUFA intake were associated with BMI, hip, and weight, and n-3 : n-6 PUFA ratio with waist circumference in men. In contrast, women (n=595 with the GG genotype had significantly lower BMI (P=0.009, hip (P=0.029, and weight (P=0.027 than GA or AA carriers (n=216. Women with the GG genotype were 50% less likely to be overweight compared to GA or AA carriers (OR = 0.05, CI = 0.27–0.91, and P=0.024. In summary, BDNF rs6265 is differentially associated with obesity risk by sex and interacts with PUFA intake influencing obesity traits in Boston Puerto Rican men.

  6. Footwear and Falls in the Home Among Older Individuals in the MOBILIZE Boston Study

    Science.gov (United States)

    Kelsey, Jennifer L.; Procter-Gray, Elizabeth; Nguyen, Uyen-Sa D. T.; Li, Wenjun; Kiel, Douglas P.; Hannan, Marian T.

    2011-01-01

    Background Whether certain types of footwear, such as slippers, socks without shoes, and going barefoot, increase the risk for falls among the elderly is uncertain. Our purpose was to examine the relationship between footwear and falls within the home in MOBILIZE Boston, a prospective cohort study of falls etiology among non-institutionalized women and men, mainly aged 70 years and older, from the Boston MA, USA area. Methods The 765 participants were from households randomly selected from town lists. They were followed for a median of 27.5 months. At baseline, participants were administered a questionnaire that included questions on footwear usually worn, and were given a comprehensive examination that included measurement of many risk factors for falls. During follow-up participants were asked to record each day whether they had fallen; those reporting falls were asked about their footwear when they fell. Results At the time of in-home falls, 51.9% of people were barefoot, wearing socks without shoes, or wearing slippers; 10.1% of people reported that their usual footwear was one of these types. Among those who fell in their own home, the adjusted odds ratio for a serious injury among those who were shoeless or wearing slippers compared to those who were wearing other shoes at the time of the fall was 2.27 (95% confidence interval 1.21–4.24). Conclusions It may be advisable for older individuals to wear shoes in their home whenever possible to minimize the risk of falling. Further research is needed to identify optimal footwear for falls prevention. PMID:22224169

  7. Risk factors for the development of retroprosthetic membranes with Boston keratoprosthesis type 1: multicenter study results.

    Science.gov (United States)

    Rudnisky, Christopher J; Belin, Michael W; Todani, Amit; Al-Arfaj, Khalid; Ament, Jared D; Zerbe, Brian J; Ciolino, Joseph B

    2012-05-01

    The purpose of this study was to identify possible risk factors for retroprosthetic membrane (RPM) development in a large, multicenter cohort of patients receiving a Boston type 1 keratoprosthesis. Cohort study. The final analysis included 265 eyes of 265 patients who underwent implantation of a Boston keratoprosthesis type I device between January 2003 and July 2008 by 1 of 19 surgeons at 18 medical centers. Forms reporting preoperative, intraoperative, and postoperative parameters were prospectively collected and subsequently analyzed at a central data collection site. The primary outcome was the presence or absence of an RPM during the follow-up period. The average age of patients was 63.3±19.1 years, 48.5% of the patients were female, and 52.5% of procedures were performed on the right eye. The mean follow-up time was 17.8±14.9 months. The majority (85.4%; n = 222) had undergone an average of 2.2±1.2 (range, 1-8) penetrating keratoplasties before keratoprosthesis implantation, and 38 eyes (14.6%) received a primary keratoprosthesis. The overall RPM formation rate was 31.7% (n = 84). The most significant risk factor for RPM development was infectious keratitis (as a surgical indication for keratoprosthesis surgery itself), resulting in a rate of RPM formation of 70.6%. As an independent risk factor, the hazard ratio (HR) of RPM development in these eyes was 3.20 (95% confidence interval, 1.66-6.17). Aniridia was also an independent risk factor for RPM development (HR, 3.13; 95% confidence interval, 1.10-8.89). Formation of RPM is a common complication of keratoprosthesis surgery, occurring in approximately one-third of cases. Eyes at the highest risk of RPM development are those receiving corneal replacement for infectious keratitis and aniridia. Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  8. Ultra high resolution optical coherence tomography in Boston type I keratoprosthesis

    Directory of Open Access Journals (Sweden)

    Siamak Zarei-Ghanavati

    2015-01-01

    Full Text Available Purpose: To evaluate the anterior keratoprosthesis-cornea interface in eyes with Boston type I keratoprosthesis (Kpro. Methods: In a prospective non-interventional study, patients with Boston type I Kpro underwent ultra-high resolution optical coherence tomography (UHR-OCT evaluation. The images were used to measure and describe characteristics of the anterior keratoprosthesis-cornea interface, epithelial interaction at the keratoprosthesis edge and the keratoprosthesis-cornea interface gap. Results: Ten patients including 4 male and 6 female subjects with different preoperative diagnoses, i.e. 8 multiple corneal graft failures and 2 immunological ocular surface diseases, were studied. Mean age was 62.1 ± 20.0 (range, 33.0-83.0 years and mean interval between surgery and UHR-OCT evaluation was 15.2 ± 11.09 months. In eight patients, 360° epithelial growth over the peripheral edge of the Kpro was documented. We detected keratoprosthesis-cornea interface gap in three patients. One subject had developed postoperative endophthalmitis 8 months after surgery and the other two cases were among the high risk group according to the preoperative diagnosis. In one patient with severe ocular hypotony, the Kpro edge was inserted into the anterior stroma and covered with epithelium. Conclusion: UHR-OCT showed that corneal epithelium covers the Kpro edge and seals the potential space between the Kpro and cornea in 80% of cases. The presence of a gap in the interface and lack of epithelial sealing around the Kpro edge might be associated with endophthalmitis.

  9. Erratum to: Endophthalmitis in Boston keratoprosthesis: case series and review of literature.

    Science.gov (United States)

    Chhablani, Jay; Panchal, Bhavik; Das, Taraparasad; Pathengay, Avinash; Motukupally, Swapna R; Pappuru, Rajeev Reddy; Basu, Sayan; Sangwan, Virender

    2015-02-01

    To report the clinical and microbiological characteristics of infectious endophthalmitis after Boston type I keratoprosthesis (B-K-Pro) implantation. Retrospective analysis of 45 eyes that received a B-K-Pro type 1 between 2009 and 2012 was performed. Five eyes with a diagnosis of exogenous endophthalmitis after B-K-pro type 1 were identified and information about demographic data, indication for K-Pro, post-operative bandage contact lens use, post-operative prophylactic antibiotic use, timing and clinical presentation of endophthalmitis, gram stain and culture results of intraocular fluid and preoperative and post-operative visual acuity were collected. The incidence of endophthalmitis was 11.1 % (5 of 45 eyes) and average time to develop endophthalmitis was 5.62 months (range 2 days to 8 months). Mean patient age was 31.4 years (5 to 65 years). The surgical indications included corneal injury due to chemical burns (n = 2), multiple failed grafts secondary to microbial keratitis (n = 2) and congenital glaucoma with congenital herpetic keratitis (n = 1). Post-Boston K-Pro, the visual acuity ranged from light perception (LP) to 20/50. K-pro was explanted in 4 patients. There was bacterial and fungal growth in two patients each and one vitreous did not grow anything. All the eyes were phthisical at last visit. Infectious endophthalmitis after K-Pro implantation in our study had a higher incidence, early onset and extremely poor visual outcome compared with post-cataract surgery endophthalmitis, as reported in literature. Not only bacterial but also fungal infections are an important etiology for infectious endophthalmitis in these cases.

  10. [Mid- and Longterm Experiences with the Boston-Keratoprosthesis. The Cologne and Salzburg Perspective].

    Science.gov (United States)

    Schaub, Friederike; Bachmann, Björn O; Seyeddain, Orang; Moussa, Sarah; Reitsamer, Herbert A; Cursiefen, Claus

    2017-06-01

    Background Eyes with severe corneal opacifications and insufficient prognosis for high-risk corneal transplantation can be considered for the implantation of a Boston-keratoprosthesis. Since 2013, this technique of "artificial" corneal replacement is provided to high-risk eyes at the Department of Ophthalmology, University of Cologne and for 9 years at the University of Salzburg. In the meantime, a type I Boston keratoprosthesis (BI-KPro) has been implanted in 24 eyes in Cologne and in 28 eyes in Salzburg. Methods In this article, results and complications according to BI-KPro are discussed, both from the literature in PubMed, as well as from our own experiences. Results Twenty-four eyes of 22 patients had been provided with a BI-KPro since September 2013, of which only one keratoprosthesis could not be obtained thus far, and an increase in visual acuity could be achieved in 23 eyes (96%). On average, 1.5 revisions per eye were required during the postoperative course. Since 2007, a BI-KPro has been implanted in 28 eyes in Salzburg. In 62% (16 of 26 eyes), visual acuity increased postoperatively, with a complication rate of 81% in a longer follow-up period. In both cohorts, the spectrum of complications ranged from retroprosthetic membrane formation, to secondary glaucoma, to infectious keratitis with or without graft melting, to vitritis, to endophthalmitis. Conclusion The range of possible complications according to BI-KPro is broad, but the BI-KPro represents currently the most widely used form of artificial corneal replacement in high-risk eyes and leads to visual improvement in most patients. Georg Thieme Verlag KG Stuttgart · New York.

  11. Medium-term outcomes of boston type 1 keratoprosthesis implantation in Bangkok, Thailand.

    Science.gov (United States)

    Lekhanont, Kaevalin; Thaweesit, Panyachat; Muntham, Dittapol; Chuckpaiwong, Varintorn; Vongthongsri, Anun

    2014-12-01

    The aim of this study was to investigate the medium-term outcomes after Boston type 1 keratoprosthesis surgery in patients with poor prognosis for standard keratoplasty. A prospective study of a case series was conducted at a university-based referral center from 2006 to 2013. Forty-two eyes of 40 patients with a minimum follow-up of 4 years were recruited. The main outcome measures included best spectacle-corrected visual acuity (BSCVA), keratoprosthesis retention, and complications. The mean follow-up was 64.9 ± 15.2 months (range, 48-88 months). At 1 week, 90.5% had an improvement in BSCVA by ≥2 lines compared with that in preoperative BSCVA. The best-ever vision was reached by the end of 6 months. Nevertheless, 39.5% (15/38) could not maintain the improved vision. The major etiology of visual deterioration after initial gains was glaucoma (60%). The initial keratoprosthesis retention rate was 80.9%, corresponding to a failure rate of 4 per 100 eye-years or 0.04/eye-year. Autoimmune diagnosis was the independent risk factor for keratoprosthesis failure (hazard ratio, 5.68; 95% confidence interval, 1.41-22.85; P = 0.014). The common postoperative complications were glaucoma, retroprosthetic membrane, corneal melting, infectious keratitis, and endophthalmitis. Boston type 1 keratoprosthesis is an alternative for patients who are not candidates for corneal transplants. However, there was a trend toward visual loss over time most commonly because of progressive glaucoma. Therefore, appropriate patient selection, lifelong follow-up, and early aggressive treatment of complications are recommended.

  12. Improving Coastal Flood Risk Assessments for the Northeastern United States: New York City to Boston

    Science.gov (United States)

    Woodruff, J. D.; Stromer, Z.; Talke, S. A.; Orton, P. M.

    2015-12-01

    Interest in extreme flood vulnerability in the Northeastern U.S. has increased significantly since Hurricane Sandy caused more than $50 billion dollars in damages. Despite increased focus there is still no overall consensus regarding the true return period in the region for flood events of Sandy's magnitude. The application of Generalized Extreme Value (GEV) theory to water level data is one of the most common techniques for estimating the return period for these rare events. Here we assess the skill of this popular technique by combining modeled, instrumental and sedimentologically derived records of flooding for the region. We show that GEV derived return periods greatly and consistently underappreciate risk for sites from New York City east to southern Cape Cod. This is in part because at these locations maximum annual flood data represents a mixture of two very different populations of storms, i.e. tropically derived disturbances and extratropical Nor'easters. Nor'easters comprise a majority of floods with 10-yr return periods and shorter, hurricanes for 100-yr floods or longer, and a combination in between. In contrast, the GEV technique functions better in estimating the 100-yr flood for points north of Cape Cod including Boston. At these locations flooding occurs more often from just one type of disturbance, i.e. Nor'easters. However, modeled and sedimentary reconstructions of storms indicate hurricanes likely still dominate flood distribution at northern location like Boston for 500 yr or greater events. Results stress the need for separating storm populations before applying the GEV technique, especially where flood behavior can vary depending on the type of disturbance.

  13. Priorities, concerns and unmet needs among Haitians in Boston after the 2010 earthquake.

    Science.gov (United States)

    Allen, Jennifer D; Leyva, Bryan; Hilaire, Dany M; Reich, Amanda J; Martinez, Linda Sprague

    2016-11-01

    In January 2010, a massive earthquake struck Haiti. The devastation not only affected those living in Haiti at the time but also those Haitians living in the United States (U.S.). Few studies have assessed the degree of impact of the earthquake in U.S. Haitian communities. The purpose of this study was to elicit information about health priorities, concerns and resources needed to improve the delivery of health and social care for Haitians in Boston, MA. We conducted six focus groups among 78 individuals in the spring of 2011. Participants were recruited through community organisations, including churches, Haitian social service centres, restaurants and by word of mouth. Analysis of qualitative data revealed an enormous psychological, emotional, financial and physical toll experienced by Boston-area Haitians following the earthquake. Participants described increased distress, depressive episodes, headaches and financial hardship. They also noted insufficient resources to meet the increased needs of those living in the U.S., and those who had immigrated after the earthquake. Most participants cited an increased need for mental health services, as well as assistance with finding employment, navigating the immigration system, and balancing the health and financial needs of families in the U.S. and in Haiti. Despite this, many reported that the tragedy created a sense of unity and solidarity within the Haitian community. These findings corroborate the need for culturally and linguistically appropriate mental health services, as well as for employment, immigration and healthcare navigation services. Participants suggested that interventions be offered through Haitian radio and television stations, as well as group events held in churches. Further research should assess the need for and barriers to utilisation of mental health services among the Haitian community. A multi-faceted approach that includes a variety of outreach strategies implemented through multiple

  14. Quaternary geology of the Boston area: Glacial events from Lake Charles to Lake Aberjona

    Science.gov (United States)

    Stone, Byron D.; Lane, John W.

    2014-01-01

    The multiple-glacial and glaciomarine Quaternary history of the Boston, Massachusetts area has been known generally since the earliest studies of the then newly recognized glacial deposits described by Prof. Louis Agassiz in the late1840’s and fossil marine shells in the drift in the 1850’s. Attention then turned to possible glacial erosional effects on the preglacial bedrock physiography, as related to rock units and structure, and to the challenges of defining useful physical and lithic characteristics of the drift by Prof. W.O. Crosby and others, 1880-1900. The problems of deducing the relative stratigraphic order among such small, fossil-barren surficial sedimentary deposits, and extending knowledge gained from studies of postulated ancient glacial lakes to a regional understanding of the history of many lakes during the retreat of the ice sheet required field work and use of geologic maps. With the advent of modern topographic maps in the 1880’s, the early period of discovery included field studies of glacial lake deposits in local river basins in the Boston region, basins that drain northward, thereby creating glacial lake basins dammed by the ice margin as it retreated to the north. Guided by M.I.T. and Harvard professors W.O. Crosby, N.S. Shaler, J.B. Woodworth, W.M. Davis, and others in the 1880-1920 period, the first Quaternary glacial stratigraphers were students (e.g. Crosby and Grabau, 1896, Clapp, 1905, Fuller 1905, Goldthwaite 1906, Grabau, 1906, Taylor, Tight).

  15. No difference in urinary iodine concentrations between Boston-area breastfed and formula-fed infants.

    Science.gov (United States)

    Gordon, Joshua H; Leung, Angela M; Hale, Andrea R; Pearce, Elizabeth N; Braverman, Lewis E; He, Xuemei; Belfort, Mandy B; Nelson, Sara M; Brown, Rosalind S

    2014-08-01

    Thyroid hormone is essential for normal mental and physical development in infancy and childhood and is dependent on adequate iodine intake. During the first few months of life, infants are reliant on breastmilk and/or infant formula as their sole sources of dietary iodine. The iodine status of U.S. infants has not been well studied. This was a cross-sectional study of 95 breastfed and/or formula-fed infants less than 3 months of age in the Boston area. We measured iodine content from infants' single spot urine samples and assessed associations with infant feeding type as well as maternal demographic data, salt and multivitamin use, smoking status, and diet. The median infant urine iodine concentration was 197.5 μg/L (range 40-897.5 μg/L). Median infant urine iodine concentrations were similar between infants who were exclusively breastfed (n=39, 203.5 μg/L; range 61.5-395.5 μg/L), formula-fed (n=44, 182.5 μg/L; range 40-897.5 μg/L), and mixed (n=10, 197.8 μg/L; range 123-592.5) (p=0.88). There were no significant correlations of infant urinary iodine with maternal salt or multivitamin use (regularly or in the past 24 hours), active or secondhand cigarette smoke exposures, infant weight, infant length, or recent maternal ingestion of common iodine-containing foods, although the correlations with iodine-containing foods are difficult to accurately determine due to the small sample sizes of these variables. Both breastfed and formula-fed infants less than 3 months of age in the Boston area were generally iodine sufficient. Larger studies are needed to confirm these observations among infants nationwide and elucidate other factors that may contribute to infant iodine nutrition.

  16. Increased pediatric functional neurological symptom disorders after the Boston marathon bombings: a case series.

    Science.gov (United States)

    Guerriero, Réjean M; Pier, Danielle B; de Gusmão, Claudio M; Bernson-Leung, Miya E; Maski, Kiran P; Urion, David K; Waugh, Jeff L

    2014-11-01

    Functional neurological symptom disorders are frequently the basis for acute neurological consultation. In children, they are often precipitated by high-frequency everyday stressors. The extent to which a severe traumatic experience may also precipitate functional neurological abnormalities is unknown. For the 2-week period after the Boston Marathon bombings, we prospectively collected data on patients whose presentation suggested a functional neurological symptom disorder. We assessed clinical and demographic variables, duration of symptoms, extent of educational impact, and degree of connection to the Marathon bombing. We contacted all patients at 6 months after presentation to determine the outcome and accuracy of the diagnosis. In a parallel study, we reported a baseline of 2.6 functional neurological presentations per week in our emergency room. In the week after the Marathon bombings, this frequency tripled. Ninety-one percent of presentations were delayed by 1 week, with onset around the first school day after a city-wide lockdown. Seventy-three percent had a history of a prior psychiatric diagnosis. At the 6 months follow-up, no functional neurological symptom disorder diagnoses were overturned and no new organic diagnosis was made. Pediatric functional neurological symptom disorder may be precipitated by both casual and high-intensity stressors. The 3.4-fold increase in incidence after the Boston Marathon bombings and city-wide lockdown demonstrates the marked effect that a community-wide tragedy can have on the mental health of children. Care providers must be aware of functional neurological symptom disorders after stressful community events in vulnerable patient populations, particularly those with prior psychiatric diagnoses. Copyright © 2014 Elsevier Inc. All rights reserved.

  17. Strategies to improve chronic disease management in seven metro Boston community health centers.

    Science.gov (United States)

    Ndumele, Chima D; Russell, Beverley E; Ayanian, John Z; Landon, Bruce E; Keegan, Thomas; O'Malley, A James; Hicks, Leroi S

    2009-01-01

    The Community, Health Center, and Academic Medicine Partnership Project (CHAMPP) is a partnership between medical researchers, community health centers (CHCs), and a community advisory committee focused on reducing cardiovascular morbidity related to hypertension and diabetes for non-Hispanic Black and Hispanic populations in Boston, Massachusetts. We conducted site visits at seven participating CHCs, located in Boston. The visits were to solicit health center staff opinions about site-specific barriers and enabling factors for optimum preventative cardiovascular care for racial/ethnic minority patients receiving hypertension and diabetes care at their centers. Site visits included a tour of each health center and a series of directed interviews with center personnel. Site visit notes were reviewed to identify themes that emerged during the course of each site visit. A summary matrix was developed for each health center, which included information regarding the most salient and persistent themes of the visit. Site visits uncovered several patient-, provider-, CHC-, and community-based factors that either facilitate or hinder optimal care of chronic disease patients. Commonly referenced barriers included the need for improved patient adherence to provider recommendations; insufficient time for providers to address complex health issues presented by patients and the need for a broader range of healthier food options in surrounding communities. Interactive patient groups and community health workers (CHWs) have been well received when implemented. Recommendations included adopting case management as a part of usual care for chronic disease patients; additionally, widespread implementation of CHWs may to provide a platform for more comprehensive care for patients.

  18. O feminicídio de Juárez: alterações económicas, narrativas sociais e discursos coloniais na fronteira dos EUA e México

    OpenAIRE

    Lobo, Patrícia Alves

    2016-01-01

    Desde maio de 1993 que, em Ciudad Juárez, centenas de mulheres foram assassinadas, violadas, torturadas e mutiladas e milhares continuam desaparecidas. Neste artigo, começa-se por evidenciar a interligação entre as alterações económicas geradas pelo Acordo de Comércio Livre da América do Norte e a destabilização dos papéis de género no norte do México, o que originou novos focos de violência contra as mulheres. Em segundo lugar, expõe-se a dialética que está subjacente aos modelos patriarcais...

  19. ESCOLAS CHARTERS NOS EUA: CONTRADIÇÕES DE UMA TENDÊNCIA PROPOSTA PARA O BRASIL E SUAS IMPLICAÇÕES PARA A OFERTA DA EDUCAÇÃO PÚBLICA 1

    OpenAIRE

    Adrião, Theresa [UNESP

    2015-01-01

    * Doutora em Educação pela Universidade de São Paulo (USP). Professora da Faculdade de Educação da Universidade Estadual de Campinas (UNICAMP), com atuação no Curso de Pedagogia e no curso de Mestrado do Programa de Pós-Graduação em Educação desta mesma instituição. E-mail: Artigo resultante de estágio pós-doutoral no exterior junto à Universidade de Maryland sob supervisão do Prof. Steve Kless, com financiamento da Fundação de Amparo à Pesquisa do Estado de São Paulo (Fa...

  20. Leucemia Mielóide Crônica: novas drogas em desenvolvimento

    Directory of Open Access Journals (Sweden)

    Cármino A. de Souza

    Full Text Available A LMC é um modelo de investigação biológica e clinica que deve ser seguido nesta nova fase da oncologia moderna. A resposta terapêutica ao uso do imatinibe como droga de primeira linha mudou os conceitos e paradigmas e criou uma expectativa que drogas mais potentes possam ser desenvolvidas no futuro. Infelizmente nem todos conseguem atingir essa situação ideal. Por esta razão, Baccarani M sugeriu que a falência de resposta subótima, precaução ou alerta fossem estudadas no sentido de serem desenvolvidas intervenções terapêuticas diferenciadas mais precoces. A resistência ao imatinibe existe e depende de vários mecanismos. Tanto mais tardia a introdução do imatinibe e mais avançada for a fase evolutiva da doença maior a freqüência de resistência. Do ponto de vista biológico, a superexpressão do BCR-ABL, os defeitos genéticos adicionais e as mutações que podem atingir várias regiões da molécula - a alça de fosfato, a alça de ativação, o domínio da quinase são os mais importantes fatores associados à resistência ao imatinibe. Por esta razão, são necessárias outras opções terapêuticas e hoje há o desenvolvimento de um grande número de drogas para um número maior de alvos. Inicialmente temos o dasatinibe, já aprovado nos EUA, na Europa e também no Brasil; o nilotinibe, em fase avançada de estudos clínicos (inclusive de fase III, e também já aprovado para uso nos EUA; o bosutinibe, o INNO - 406 bem como outras drogas que atuam em alvos como as aurora-quinases ou inibidores de histona-deacetilases.

  1. Phytochemical and Biological Studies of <em>Agave em>attenuata>

    Directory of Open Access Journals (Sweden)

    Vincenzo de Feo

    2012-05-01

    Full Text Available The present study was conducted to examine various biological activities of a methanol extract of <em>Agave attenuataem> leaves. GC-MS analysis of the <em>n>-hexane fraction from the extract revealed the presence of 31 compounds, with mono-2-ethylhexyl phthalate (11.37%, 1,2-benzenedicarboxylic acid (6.33%, <em>n>-docosane (6.30% and eicosane (6.02% as the major components. The leaves contained appreciable levels of total phenolic contents (10.541–39.35 GAE, mg/100 g and total flavonoid contents (43.35–304.8 CE, mg/100 g. The extract and some of its fractions showed moderate antimicrobial effects. Leaves extract and fractions also exhibited a good antioxidant potential when measured by DPPH radical scavenging activity and inhibition of lipid peroxidation assays. The hemolytic effect of the plant was found to be in a range of 1.01%–2.64%. From the present study it is concluded that this plant could be used as a source of natural antioxidants and functional food nutraceutical applications.

  2. A política penal de drogas proibidas nos EUA e Brasil: uma breve introdução histórica / Penal policy and illegal drugs in USA and Brazil: a brief introduction

    Directory of Open Access Journals (Sweden)

    Vitor Stegemann Dieter

    2011-09-01

    Full Text Available Resumo O discurso das drogas proibidas passa por mutações antes de depois da década de sessenta. Antes todo possuidor era tratado como delinquente, porém com o consumo das classes médias surge o discurso médico-jurídico. Médico para os consumidores, jurídico para vendedores. O Brasil importou tal problemática promulgando a lei 11.343/06 que cria um tratamento mais rígido às drogas, em relação ao traficante, e menos rígido em relação ao usuário. Palavras-chave: tráfico de drogas; discurso médico-jurídico; criminalização das drogas Abstract The discourse of illegal drugs has passed through a series of mutations seen before and after the sixties. Before, mere possession lied to a criminal treatment, but with the consumption of middle and upper classes the discourse changes to a medical-legal treatment. Brazil imported this issue from oversea, promulgating the law 11.343/06 which establishes a hard punishment on dealing and less rigid treatment to users. Keywords: drug trafficking; medical-legal discourse; drug criminalization

  3. Avaliação do questionário de Boston aplicado no pós-operatório tardio da síndrome do tunel do carpo operados pela técnica de retinaculótomo de paine por via palmar Evaluation of Boston questionnaire applied at late pos-operative period of carpal tunnel syndrome operated with the paine retinaculatome through palmar port

    Directory of Open Access Journals (Sweden)

    Lia Miyamoto Meirelles

    2006-01-01

    Full Text Available Entre os anos de 1995 e 1998, foram realizadas 112 cirurgias para tratamento da Síndrome do Túnel do Carpo (STC pela técnica de incisão palmar e utilização do retináculo de Paine. Com o objetivo de avaliar os resultados em longo prazo, os pacientes foram convocados. Houve o retorno de 44 pacientes. Deste total, três pacientes, por terem doenças associadas, foram excluídos, resultando, um total de 53 mãos analisadas. Apresentaremos os resultados da avaliação subjetiva, obtidos através da aplicação de um teste de auto-avaliação chamado de questionário de Boston. Este questionário consiste em perguntas que avaliam a gravidade dos sintomas e o estado funcional no momento da aplicação do mesmo. Através da aplicação do referido questionário encontramos um escore de 1,41 ± 0,57 para gravidade dos sintomas e 1,59 ± 0,93 para o estado funcional. Como este questionário não foi aplicado no pré-operatório deste grupo de pacientes analisados, comparou-se a pontuação obtida com as encontradas na literatura pertinente. Os resultados obtidos demonstraram que as pontuações pós-operatórias são similares àquelas existentes na literatura, mesmo sendo referidas a tempos diferentes de seguimento pós-operatórios, concluindo que havendo uma melhora dos sintomas, o questionário de Boston é sensível a esta mudança clínica.Between the years of 1995 and 1998, 112 surgeries were performed for treating Carpal Tunnel Syndrome (CTS using the technique of palmar incision employing the Paine retinaculum. With the objective of analyzing results in the long-term, the patients were called for review. Forty four patients returned. From these, three patients were excluded due to associated diseases, thus resulting in a total of 53 hands assessed. Here we present the results of the subjective evaluation achieved by applying a self-assessment test called Boston questionnaire. This questionnaire consists of questions evaluating symptoms

  4. St. Clair, Guy: Knowledge services. A strategic framework for the 21st century organization. Berlin / Boston: De Gruyter Saur 2016 (Current Topics in Library and Information Practice)

    OpenAIRE

    Thalmair, Rene

    2017-01-01

    Review of the book "Knowledge services. A strategic framework for the 21st century organization" by Guy St. Clair, Berlin ; Boston: De Gryuter Saur 2016 (Current Topics in Library and Information Practice).

  5. EASE-Grid 2.0 Land-Ocean-Coastline-Ice Masks Derived from Boston University MODIS/Terra Land Cover Data

    Data.gov (United States)

    National Aeronautics and Space Administration — These Land-Ocean-Coastline-Ice (LOCI) files provide land classification masks derived from the Boston University MOD12Q1 V004 MODIS/Terra 1 km Land Cover Product...

  6. Isolation and Expression of Glucosinolate Synthesis Genes <em>CYP83A1em> and <em>CYP83B1em> in Pak Choi (<em>Brassica em>rapa> L. ssp. <em>chinensis> var. <em>communis> (N. Tsen & S.H. Lee Hanelt

    Directory of Open Access Journals (Sweden)

    Huasen Wang

    2012-05-01

    Full Text Available <em>CYP83A1em> and <em>CYP83B1em> are two key synthesis genes in the glucosinolate biosynthesis pathway. <em>CYP83A1em> mainly metabolizes the aliphatic oximes to form aliphatic glucosinolate and <em>CYP83B1em> mostly catalyzes aromatic oximes to synthesis corresponding substrates for aromatic and indolic glucosinolates. In this study, two <em>CYP83A1em> genes named <em>BcCYP83A1-1em> (JQ289997, <em>BcCYP83A1-2em> (JQ289996 respectively and one <em>CYP83B1em> (<em>BcCYP83B1em>, HM347235 gene were cloned from the leaves of pak choi (<em>Brassica rapaem> L. ssp. <em>chinensis em>var. <em>communis em>(N. Tsen & S.H. Lee Hanelt “Hangzhou You Dong Er” cultivar. Their ORFs were 1506, 1509 and 1500 bp in length, encoding 501, 502 and 499 amino acids, respectively. The predicted amino acid sequences of <em>CYP83A1-1em>, <em>CYP83A1-2 em>and <em>CYP83B1em> shared high sequence identity of 87.65, 86.48 and 95.59% to the corresponding ones in <em>Arabidopsis>, and 98.80, 98.61 and 98.80% to the corresponding ones in <em>Brassica pekinensis em>(Chinese cabbage, respectively. Quantitative real-time PCR analysis indicated that both <em>CYP83A1em> and <em>CYP83B1em> expressed in roots, leaves and petioles of pak choi, while the transcript abundances of <em>CYP83A1 em>were higher in leaves than in petioles and roots, whereas <em>CYP83B1 em>showed higher abundances in roots. The expression levels of glucosinolate biosynthetic genes were consistent with the glucosinolate profile accumulation in shoots of seven cultivars and three organs. The isolation and characterization of the glucosinolate synthesis genes in pak choi would promote the way for further development of agronomic traits via genetic engineering.

  7. Postoperative posterior segment complications in eyes treated with the Boston type I keratoprosthesis.

    Science.gov (United States)

    Goldman, Darin R; Hubschman, Jean-Pierre; Aldave, Anthony J; Chiang, Allen; Huang, Jennifer S; Bourges, Jean-Louis; Schwartz, Steven D

    2013-03-01

    To describe the incidence, timing, visual significance, and management of posterior segment complications after Boston type I keratoprosthesis implantation. A retrospective chart review was conducted of all consecutive Boston type I keratoprostheses implanted by a single surgeon at a single institution over a 6-year period. Preoperative demographics, postoperative complications, and postoperative visual acuity outcomes were analyzed. One hundred and ten keratoprostheses were implanted in 98 eyes of 94 patients during the period under review. A minimum of 6-month follow-up was available for 83 eyes, with a mean follow-up of 28.2 months (range 6-84 months, median 23.7 months). The mean time to occurrence of any posterior segment complication was 5.6 months (range 0-42.1 months, median 5.2 months, n = 38). After keratoprosthesis surgery, 63% of all eyes had corrected distance visual acuity of 20/200 or better at last follow-up compared with 10% of eyes preoperatively. Thirty-eight eyes (40.9%) experienced at least 1 postoperative posterior segment complication, the most common of which were retinal detachment (16.9%, 14 of 83), choroidal detachment (16.9%, 14 of 83), and sterile vitritis (14.5%, 12 of 83). Corrected distance visual acuity was worse among eyes that experienced posterior segment complications compared with eyes that did not at multiple postoperative follow-up intervals (statistically significant up to 3 years) and at last follow-up (logarithm of the minimum angle of resolution ± SD = 1.45 ± 0.78 vs. 0.89 ± 0.81, P = 0.003). Posterior segment complications occur in a significant percentage of patients after keratoprosthesis surgery, resulting in a persistent reduction of visual acuity in a significant proportion of the affected eyes (corrected distance visual acuity ≤ 20/400 in 61% with complications vs. 24% without complications at last follow-up). Given this, and the anatomic difficulties associated with management of posterior segment

  8. Long-term Visual Outcomes and Complications of Boston Keratoprosthesis Type II Implantation.

    Science.gov (United States)

    Lee, Ramon; Khoueir, Ziad; Tsikata, Edem; Chodosh, James; Dohlman, Claes H; Chen, Teresa C

    2017-01-01

    To report the long-term visual outcomes and complications after Boston keratoprosthesis type II implantation in the largest single-center case series with the longest average follow-up. Retrospective review of consecutive clinical case series. Between January 1992 and April 2015 at the Massachusetts Eye and Ear Infirmary, 48 eyes of 44 patients had keratoprosthesis type II implanted by 2 surgeons (C.H.D. and J.C.). For each eye, data were collected and analyzed on the preoperative characteristics, intraoperative procedures, and postoperative course. Visual acuity outcomes, postoperative complications, and device retention. The most common indications for surgery were Stevens-Johnson syndrome in 41.7% (20 of 48 eyes) and mucous membrane pemphigoid in 41.7% (20 of 48 eyes). Mean follow-up duration was 70.2 months (standard deviation, 61.8 months; median, 52 months; range, 6 months to 19.8 years). Almost all patients (95.8%, 46 of 48 eyes) had a preoperative visual acuity of 20/200 or worse. Postoperative visual acuity improved to 20/200 or better in 37.5% (18 of 48 eyes) and to 20/100 or better in 33.3% (16 of 48 eyes) at the last follow-up visit. The most common postoperative complication was retroprosthetic membrane formation in over half (60.4%, 29 of 48 eyes). The most pressing postoperative complication was glaucoma onset or progression in about a third. Preexisting glaucoma was present in 72.9% (35 of 48 eyes). Glaucoma progressed in 27.1% (13 of 48 eyes) and was newly diagnosed in 8.3% (4 of 48 eyes) after surgery. Other postoperative complications were tarsorrhaphy revision in 52.1% (25 of 48 eyes), retinal detachment in 18.8% (9 of 48 eyes), infectious endophthalmitis in 6.3% (3 of 48 eyes), and choroidal detachment or hemorrhage in 8.3% (4 of 48 eyes). Half of eyes retained their initial keratoprosthesis at the last follow-up (50.0%, 24 of 48 eyes). The Boston keratoprosthesis type II is a viable option to salvage vision in patients with poor prognosis for

  9. Technological advances shaping scleral lenses: the Boston ocular surface prosthesis in patients with glaucoma tubes and trabeculectomies.

    Science.gov (United States)

    Tanhehco, Tasha; Jacobs, Deborah S

    2010-01-01

    The Boston Ocular Surface Prosthesis (BOS-P) (Boston Foundation for Sight, Needham, MA) is a fluid-ventilated rigid gas-permeable scleral lens that is utilized for the treatment of irregular corneal astigmatism and severe ocular surface disease. Recent reports have highlighted the utility of the BOS-P as a therapeutic device in cases of persistent epithelial defects, corneal neovascularization, ocular graft versus host disease, and exposure keratopathy. Patients with significant cornea disease might also have glaucoma, and those who have undergone glaucoma surgery, which typically disrupts the limbus, present a challenge when fitting the BOS-P. This report describes five patients with a history of both corneal disease and glaucoma surgery who were successfully fitted with the BOS-P.

  10. Linking crime guns: the impact of ballistics imaging technology on the productivity of the Boston Police Department's Ballistics Unit.

    Science.gov (United States)

    Braga, Anthony A; Pierce, Glenn L

    2004-07-01

    Ballistics imaging technology has received national attention as a potent tool for moving the law enforcement response to violent gun criminals forward by linking multiple crime scenes to one firearm. This study examines the impact of ballistics imaging technology on the productivity of the Boston Police Department's Ballistics Unit. Using negative binomial regression models to analyze times series data on ballistics matches, we find that ballistics imaging technology was associated with a more than sixfold increase in the monthly number of ballistics matches made by the Boston Police Department's Ballistics Unit. Cost-effectiveness estimates and qualitative evidence also suggest that ballistics imaging technology allows law enforcement agencies to make hits that would not have been possible using traditional ballistics methods.

  11. Boston type 1 based keratoprosthesis (Auro Kpro) and its modification (LVP Kpro) in chronic Stevens Johnson syndrome.

    Science.gov (United States)

    Basu, Sayan; Sureka, Shraddha; Shukla, Rashmi; Sangwan, Virender

    2014-03-24

    Two young women with completely dry and keratinised eyes post-Stevens Johnson Syndrome (SJS) underwent unilateral oral mucous membrane grafts (MMGs) in preparation for modified osteo-odonto keratoprosthesis (MOOKP) implantation. In both cases, the mucosal graft was deemed to be too tight to accommodate the MOOKP implant. Instead of proceeding with MOOKP, the first patient underwent Auro Kpro (Boston type 1-based keratoprosthesis) implantation under the MMG, while the second patient underwent implantation of a modification of Auro Kpro with a longer optical stem (LVP Kpro) exposed through the MMG. Both patients maintained a visual acuity of 20/20, N6 at 15 months post-implantation. The first patient needed repeated mucosal trimming because of mucosal overgrowth; while in the second patient, mucosal overgrowth did not occur. This report highlights the innovative and successful use of Boston type 1-based keratoprosthesis (Auro Kpro) and its modification (LVP Kpro) in completely dry and keratinised post-SJS eyes.

  12. Measurements and modeling of CH4 and CO2 in the Boston Metro area and Northeastern Megalopolis

    Science.gov (United States)

    Wofsy, S. C.; McKain, K.; Chen, J.; Levi, P.; Gottlieb, E.; Hutyra, L.; Raciti, S. M.; Phillips, N. G.; Callahan, W.; Decola, P.; Jones, T.; Hegarty, J. D.; Nehrkorn, T.; Mountain, M.; Eluszkiewicz, J.; Henderson, J.; Budney, J.; Sweeney, C.

    2013-12-01

    We describe a multiscale measurement network and model-data analysis framework for the Boston Metro region, with extension to the mid-Atlantic urban corridor. Observations include a network of automated concentrations of CO2 and CH4 inside and outside the urban domain, near the surface, on towers and tall buildings, total column measurements using the sun as a source, aerosol lidar data defining atmospheric structure, and meteorological data. The model-data analysis framework includes high resolution WRF fields for meteorology, detailed representation of surface sources down to the street and building level, the STILT Lagrangian Particle Dispersion model, and an inversion framework. We show examples of data and discuss considerations of sampling design for the observation network, including extension to the NE urban corridor. We also present examples of inverse analysis assessing anthropogenic emission rates for CH4 and CO2 in the urban region of metro Boston and along the urban-rural gradient.

  13. Caffeine in Boston Harbor past and present, assessing its utility as a tracer of wastewater contamination in an urban estuary.

    Science.gov (United States)

    Cantwell, Mark G; Katz, David R; Sullivan, Julia C; Borci, Todd; Chen, Robert F

    2016-07-15

    Sites throughout Boston Harbor were analyzed for caffeine to assess its utility as a tracer in identifying sources of sanitary wastewater. Caffeine ranged from 15ng/L in the outer harbor to a high of 185ng/L in the inner harbor. Inner harbor concentrations were a result of combined sewage overflow (CSO) events as well as illicit discharge of sanitary sewage into municipal storm drains. Comparing current results to data from 1998 to 1999 shows reductions in caffeine levels. Reductions are attributed to termination of effluent discharge to the harbor, declines in the number of CSOs and discharge volume along with efforts to eliminate illicit discharges. Spatial distributions of caffeine identified CSOs as major contemporary sources to the inner harbor. The findings further establish the utility of caffeine as a tracer for sanitary wastewater contamination in urban estuaries and demonstrate the efficacy of pollution reduction strategies undertaken in recent decades in Boston Harbor. Published by Elsevier Ltd.

  14. Effect of School District Policy Change on Consumption of Sugar-Sweetened Beverages Among High School Students, Boston, Massachusetts, 2004-2006

    OpenAIRE

    Cradock, Angie L.; McHugh, Anne; Mont-Ferguson, Helen; Grant, Linda; Barrett, Jessica L; Gortmaker, Steven L.; Wang, Claire

    2011-01-01

    Introduction Consumption of sugar-sweetened beverages has increased among youth in recent decades, accounting for approximately 13% of total calories consumed. The Boston Public Schools passed a policy restricting sale of sugar-sweetened beverages in Boston schools in June 2004. The objective of this study was to determine whether high school students' consumption of sugar-sweetened beverages declined after this new policy was implemented. Methods We conducted a quasi-experimental evaluation ...

  15. Epithelial growth over the optic surface of the type 1 Boston Keratoprosthesis: histopathology and implications for biointegration

    Directory of Open Access Journals (Sweden)

    Yousuf M Khalifa

    2010-09-01

    Full Text Available Yousuf M Khalifa, Don Davis, Nick Mamalis, Majid MoshirfarMoran Eye Center, University of Utah, Salt Lake City, UT, USAAbstract: We report the histopathology of epithelial overgrowth in the Boston type I keratoprosthesis. The epithelium shows an inconsistent number of layers and basement membrane and goblet cells are absent. Epithelialization of the keratoprosthesis optic would have multiple advantages, but the limitation of vision makes tolerating the overgrowth difficult.Keywords: keratoprosthesis, cornea, corneal transplant, biocompatibility, biointegration epithelium

  16. Beyond Anal Sex: Sexual Practices Associated with HIV Risk Reduction among Men Who Have Sex with Men in Boston, Massachusetts

    OpenAIRE

    Reisner, Sari L.; Mimiaga, Matthew J.; Skeer, Margie; Mayer, Kenneth H.

    2009-01-01

    Men who have sex with men (MSM) continue to bear a disproportionate HIV and sexually transmitted disease (STD) burden. The current study examined the frequency and associations of sexual risk reduction behaviors among a sample of MSM in the greater Boston, Massachusetts area. One hundred eighty-nine MSM completed a one-time behavioral and psychosocial assessment between March 2006 and May 2007. Logistic regression procedures examined the association of demographic, psychosocial, and behaviora...

  17. Effectiveness of the Rigo Ch?neau versus Boston-style orthoses for adolescent idiopathic scoliosis: a retrospective study

    OpenAIRE

    Minsk, Miriam K.; Venuti, Kristen D.; DAUMIT, GAIL L; Sponseller, Paul D

    2017-01-01

    Background Bracing can effectively treat adolescent idiopathic scoliosis (AIS), but patient outcomes have not been compared by brace type. We compared outcomes of AIS patients treated with Rigo Ch?neau orthoses (RCOs) or custom-molded Boston-style thoracolumbosacral orthoses (TLSOs). Methods We retrospectively reviewed patient records from one scoliosis center from 1999 through 2014. Patients were studied from initial treatment until skeletal maturity or surgery. Inclusion criteria were a dia...

  18. Reference Gene Selection in the Desert Plant <em>Eremosparton songoricuem>m>

    Directory of Open Access Journals (Sweden)

    Dao-Yuan Zhang

    2012-06-01

    Full Text Available <em>Eremosparton songoricum em>(Litv. Vass. (<em>E. songoricumem> is a rare and extremely drought-tolerant desert plant that holds promise as a model organism for the identification of genes associated with water deficit stress. Here, we cloned and evaluated the expression of eight candidate reference genes using quantitative real-time reverse transcriptase polymerase chain reactions. The expression of these candidate reference genes was analyzed in a diverse set of 20 samples including various <em>E. songoricumem> plant tissues exposed to multiple environmental stresses. GeNorm analysis indicated that expression stability varied between the reference genes in the different experimental conditions, but the two most stable reference genes were sufficient for normalization in most conditions.<em> EsEFem> and <em>Esα-TUB> were sufficient for various stress conditions, <em>EsEF> and <em>EsACT> were suitable for samples of differing germination stages, and <em>EsGAPDH>and <em>Es>UBQ em>were most stable across multiple adult tissue samples. The <em>Es18Sem> gene was unsuitable as a reference gene in our analysis. In addition, the expression level of the drought-stress related transcription factor <em>EsDREB2em>> em>verified the utility of<em> E. songoricumem> reference genes and indicated that no single gene was adequate for normalization on its own. This is the first systematic report on the selection of reference genes in <em>E. songoricumem>, and these data will facilitate future work on gene expression in this species.

  19. Use of a Porous Polyethylene Lid Spacer for Management of Eyelid Retraction in Patients with Boston Type II Keratoprosthesis

    Science.gov (United States)

    Sivaraman, Kavitha R.; Aakalu, Vinay K.; Sajja, Kiran; Cortina, Maria Soledad; de la Cruz, Jose; Setabutr, Pete

    2014-01-01

    Purpose: To report a novel application of a porous polyethylene implant for lid stabilization and management of eyelid retraction in a patient with an exposed Boston Keratoprosthesis Type II. Methods: A 54-year-old woman with a history of mucous membrane pemphigoid and failed penetrating keratoplasty of the left eye underwent implantation of a Boston Keratoprosthesis (KPro) Type II along with permanent surgical fusion of the upper and lower lids of the left eye in January 2010. At one month follow-up, significant retraction of the lower lid around the inferior margin of the optic was noted, resulting in partial exposure of the keratoprosthesis. The patient subsequently underwent left lower eyelid reconstruction with a porous polyethylene implant to ensure coverage and stability of the KPro. Results: Eyelid reconstruction using a porous polyethylene implant resulted in stable retention of the KPro Type II for over 2 years. Conclusion: In patients with Boston KPro Type II in the setting of severe cicatrizing ocular surface disease, the use of a porous polyethylene implant during eyelid reconstruction around the KPro optic may aid in maintaining eyelid integrity and improving KPro stability and longevity. PMID:23663113

  20. Boston type I keratoprosthesis for treatment of gelatinous drop-like corneal dystrophy after repeated graft failure.

    Science.gov (United States)

    Fadlallah, A; Jakobiec, F A; Mendoza, P R; Zalloua, P A; Melki, S A

    2015-03-01

    To describe the use of a Boston type I keratoprosthesis as a secondary penetrating procedure to treat gelatinous drop-like corneal dystrophy (GDLD), with presentation of pathologic findings, genetic analysis, and discussion of other surgical options. A 43-year-old woman with GDLD in both eyes, best corrected visual acuity (BCVA) of counting fingers in both eyes, and recurrent corneal opacification following two penetrating keratoplasties presented for visual rehabilitation. A Boston type I keratoprosthesis was implanted in her left eye after extracapsular clear lens extraction. The surgery was uneventful and one month after surgery, best corrected vision improved to 20/30, which has been maintained for a period of more than nine months. At the 12-month visit, her vision was noted to be diminished to 20/200 due to a retroprosthetic membrane and improved to 20/25 two weeks after a Yag capsulotomy. Histopathologic examination of the corneal specimen disclosed predominantly subepithelial amyloid deposition. Genetic analysis is presented. GDLD is a rare disorder of primary corneal amyloidosis. Recurrence of this condition following surgery is very common. Boston type I keratoprosthesis as a secondary procedure can be successful in restoring vision in affected patients.

  1. Advantages of microscope-integrated intraoperative online optical coherence tomography: usage in Boston keratoprosthesis type I surgery

    Science.gov (United States)

    Siebelmann, Sebastian; Steven, Philipp; Hos, Deniz; Hüttmann, Gereon; Lankenau, Eva; Bachmann, Björn; Cursiefen, Claus

    2016-01-01

    Boston keratoprosthesis (KPro) type I is a technique to treat patients with corneal diseases that are not amenable to conventional keratoplasty. Correct assembly and central implantation of the prosthesis are crucial for postoperative visual recovery. This study investigates the potential benefit of intraoperative optical coherence tomography (OCT) to monitor KPro surgery. Retrospective case series are presented for two patients who underwent Boston KPro type I implantation. The surgery in both patients was monitored intraoperatively using a commercially available intraoperative OCT (iOCT) device mounted on a surgical microscope. Microscope-integrated intraoperative OCT was able to evaluate the correct assembly and implantation of the KPro. All parts of the prosthesis were visible, and interfaces between the corneal graft and titanium backplate or anterior optics were clearly depictable. Moreover, iOCT visualized a gap between the backplate and graft in one case, and in the other case, a gap between the anterior optic and graft. Neither gap was visible with a conventional surgical microscope. The gap between the anterior optic and the graft could easily be corrected. Microscope-integrated iOCT delivers enhanced information, adding to the normal surgical microscope view during KPro surgery. Correct assembly can be controlled as well as the correct placement of the Boston KPro into the anterior chamber.

  2. Shaken but prepared: Analysis of disaster response at an academic medical centre following the Boston Marathon bombings.

    Science.gov (United States)

    Osgood, Robert; Scanlon, Courtney; Jotwani, Rohan; Rodkey, Daniel; Arshanskiy, Maria; Salem, Deeb

    Over the last decade, there has been a rise in the number of mass casualty incidences (MCIs) and their subsequent effect on hospital systems. While there has been much discussion over improving procedures to treat victims of MCIs, there has not been a thorough, systems-based analysis concerning the costs incurred by hospitals during such events. Here the authors examine the history of the Hospital Incident Command Center and how its evolution at Tufts Medical Center helped mitigate the damage following the Boston Marathon Bombings. Tufts' unique variations to the Hospital Incident Command Center include strategic communication hierarchies and a 'zero cost centre' financial system which both provided for a quick and adaptive response. Operating in collaboration with the Conference of Boston Teaching Hospitals encouraged coordination and preparation during emergency situations such as mass casualty events. The direct and indirect effects on Tufts Medical Center stemming from the Boston Marathon Bombings were analysed. Tufts MC treated 36 victims immediately following the MCI. The estimated total cost during the week of April 15 to April 19, 2013 was $776,051. The cost was primarily comprised of lost revenue from cancelled outpatient and inpatient hospital services, as well as expenses incurred due to overtime pay, salary expenses, PPE kits and hospitality services. Finally, the authors examine ways to reduce the future costs during emergency situations through increasing communication with employees, understanding the source of all direct expenses, and mitigating excess risk by developing partnerships with other hospital systems.

  3. Biochemical and Molecular Analysis of the Hb Lepore Boston Washington in a Syrian Homozygous Child.

    Science.gov (United States)

    Pirastru, Monica; Manca, Laura; Trova, Sandro; Mereu, Paolo

    2017-01-01

    Hemoglobin (Hb) Lepore is composed of two normal α chains and two δβ fusion globins that arise from unequal crossover events between the δ- and β-globin genes. The Hb Lepore is widespread all over the world and in many ethnic groups. It includes some of the few clinically significant Hb variants that are associated with a β-thalassemia phenotype. Here, we describe the first occurrence of Hb Lepore Boston Washington in a Syrian individual. The patient, a 10-year-old child, shows severe anemia with a Hb level of 6.85 g/dL and typical thalassemic red cell indices. The diagnostic procedure implies hematological, biochemical, and molecular analysis, including multiplex ligation-dependent probe amplification (MLPA) assay, GAP-PCR, and DNA sequencing. This latter allowed us to define the correct structure of the hybrid δβ-globin gene. The knowledge of the spectrum of mutations associated with different geographical areas is the prerequisite to set up large-scale screening programs and be able to offer genetic counseling to couples at risk.

  4. Biochemical and Molecular Analysis of the Hb Lepore Boston Washington in a Syrian Homozygous Child

    Directory of Open Access Journals (Sweden)

    Monica Pirastru

    2017-01-01

    Full Text Available Hemoglobin (Hb Lepore is composed of two normal α chains and two δβ fusion globins that arise from unequal crossover events between the δ- and β-globin genes. The Hb Lepore is widespread all over the world and in many ethnic groups. It includes some of the few clinically significant Hb variants that are associated with a β-thalassemia phenotype. Here, we describe the first occurrence of Hb Lepore Boston Washington in a Syrian individual. The patient, a 10-year-old child, shows severe anemia with a Hb level of 6.85 g/dL and typical thalassemic red cell indices. The diagnostic procedure implies hematological, biochemical, and molecular analysis, including multiplex ligation-dependent probe amplification (MLPA assay, GAP-PCR, and DNA sequencing. This latter allowed us to define the correct structure of the hybrid δβ-globin gene. The knowledge of the spectrum of mutations associated with different geographical areas is the prerequisite to set up large-scale screening programs and be able to offer genetic counseling to couples at risk.

  5. Breastfeeding and coffee consumption in children younger than 2 years in Boston, Massachusetts, USA.

    Science.gov (United States)

    Burnham, Laura; Matlak, Stephanie; Makrigiorgos, Gregory; Braun, Natalie; Knapp, Becky Perreault; Merewood, Anne

    2015-05-01

    Although introduction of inappropriate foods and liquids in early childhood and their association with breastfeeding is commonly reported in US children, coffee use in very young US children and its association with breastfeeding is not. This study aimed to determine the proportion of 1- and 2-year-olds in an urban population consuming coffee, their rate of consumption, and predictors of consumption, including breastfeeding status. We used data from a prospective cohort study on infant weight gain and diet, and body mass index at age 2. We used bivariate analyses to examine variables associated with coffee consumption at 1 and 2 years and multivariate logistic regression to control for variables of interest. This study included 315 mother-infant dyads. At 1 year, the rate of coffee consumption reported was 2.5%; at 2 years, it was 15.2% and average daily consumption was 1.09 oz (range, 0.01- 4.00 oz). The only characteristic associated with coffee consumption at 1 year was breastfeeding at 1 year (P = .0275), which did not remain significant after controlling for confounding variables. Variables significantly associated with coffee consumption at year 2 were lower maternal education (P = .0016), non-US maternal place of birth (P = .0015), maternal Hispanic ethnicity (P Coffee consumption is not uncommon among toddlers in Boston, Massachusetts, USA. After controlling for possible confounding factors, maternal ethnicity and infant sex were significantly associated with this practice. © The Author(s) 2015.

  6. Traffic-related air pollution and sleep in the Boston Area Community Health Survey.

    Science.gov (United States)

    Fang, Shona C; Schwartz, Joel; Yang, May; Yaggi, H Klar; Bliwise, Donald L; Araujo, Andre B

    2015-01-01

    Little is known about environmental determinants of sleep. We investigated the association between black carbon (BC), a marker of traffic-related air pollution, and sleep measures among participants of the Boston Area Community Health Survey. We also sought to assess the impact of sociodemographic factors, health conditions, and season on associations. Residential 24-h BC was estimated from a validated land-use regression model for 3821 participants and averaged over 1-6 months and 1 year. Sleep measures included questionnaire-assessed sleep duration, sleep latency, and sleep apnea. Linear and logistic regression models controlling for confounders estimated the association between sleep measures and BC. Effect modification was tested with interaction terms. Main effects were not observed between BC and sleep measures. However, in stratified models, males experienced 0.23 h less sleep (95% CI: -0.42, -0.03) and those with low SES 0.25 h less sleep (95% CI: -0.48, -0.01) per IQR increase in annual BC (0.21 μg/m(3)). In blacks, sleep duration increased with annual BC (β=0.34 per IQR; 95% CI: 0.12, 0.57). Similar findings were observed for short sleep (≤5 h). BC was not associated with sleep apnea or sleep latency, however, long-term exposure may be associated with shorter sleep duration, particularly in men and those with low SES, and longer sleep duration in blacks.

  7. The Great Diseases Project: a partnership between Tufts Medical School and the Boston public schools.

    Science.gov (United States)

    Jacque, Berri; Malanson, Katherine; Bateman, Kathleen; Akeson, Bob; Cail, Amanda; Doss, Chris; Dugan, Matt; Finegold, Brandon; Gauthier, Aimee; Galego, Mike; Roundtree, Eugene; Spezzano, Lawrence; Meiri, Karina F

    2013-05-01

    Medical schools, although the gatekeepers of much biomedical education and research, rarely engage formally with K-12 educators to influence curriculum content or professional development. This segregation of content experts from teachers creates a knowledge gap that limits inclusion of current biomedical science into high school curricula, affecting both public health literacy and the biomedical pipeline. The authors describe how, in 2009, scientists from Tufts Medical School and Boston public school teachers established a partnership of formal scholarly dialogue to create 11th- to 12th-grade high school curricula about critical health-related concepts, with the goal of increasing scientific literacy and influencing health-related decisions. The curricula are based on the great diseases (infectious diseases, neurological disorders, metabolic disease, and cancer). Unlike most health science curricular interventions that provide circumscribed activities, the curricula are comprehensive, each filling one full term of in-class learning and providing extensive real-time support for the teacher. In this article, the authors describe how they developed and implemented the infectious disease curriculum, and its impacts. The high school teachers and students showed robust gains in content knowledge and critical thinking skills, whereas the Tufts scientists increased their pedagogical knowledge and appreciation for health-related science communication. The results show how formal interactions between medical schools and K-12 educators can be mutually beneficial.

  8. Predictors of tetrabromobisphenol-A (TBBP-A) and hexabromocyclododecanes (HBCD) in milk from Boston mothers.

    Science.gov (United States)

    Carignan, Courtney C; Abdallah, Mohamed Abou-Elwafa; Wu, Nerissa; Heiger-Bernays, Wendy; McClean, Michael D; Harrad, Stuart; Webster, Thomas F

    2012-11-06

    Tetrabromobisphenol-A (TBBP-A) and hexabromocyclododecanes (HBCDs) are brominated flame retardants that have been found in human milk and serum throughout the world, but have received comparatively little attention in the United States. The objective of this study is to determine concentrations of these analytes in samples of breast milk collected from first-time mothers in the Greater Boston, Massachusetts area and to explore predictors of exposure. Human milk samples were analyzed by LC-ESI-MS/MS for TBBP-A, HBCDs (the α, β, and γ diastereomers), and HBCD degradation products: pentabromocyclododecanes (PBCDs) and tetrabromocyclododecadienes (TBCDs). HBCD diastereomers were detected in all samples with α-HBCD present in the highest proportion. TBBP-A, PBCDs, and TBCDs were detected in 35%, 42%, and 56% of the analyzed samples, respectively. Self-reported demographic, dietary and behavioral data were examined as predictors of HBCD levels. Levels of HBCD were significantly, positively associated with the number of stereo and video electronics in the home (17% increase/item; 95% Confidence Interval (CI) = 4-31%) and reduced in participants who regularly chose organic foods compared to those who did not (0.51, 95% CI = 0.32-0.82). These results suggest that lifestyle factors are related to body burdens of HBCD and that domestic electronics may be an important source of HBCD exposure in the indoor environment.

  9. Assessment of a Districtwide Policy on Availability of Competitive Beverages in Boston Public Schools, Massachusetts, 2013

    Science.gov (United States)

    Gortmaker, Steven L.; Kenney, Erica L.; Carter, Jill E.; Howe, M. Caitlin Westfall; Reiner, Jennifer F.; Cradock, Angie L.

    2016-01-01

    Introduction Competitive beverages are drinks sold outside of the federally reimbursable school meals program and include beverages sold in vending machines, a la carte lines, school stores, and snack bars. Competitive beverages include sugar-sweetened beverages, which are associated with overweight and obesity. We described competitive beverage availability 9 years after the introduction in 2004 of district-wide nutrition standards for competitive beverages sold in Boston Public Schools. Methods In 2013, we documented types of competitive beverages sold in 115 schools. We collected nutrient data to determine compliance with the standards. We evaluated the extent to which schools met the competitive-beverage standards and calculated the percentage of students who had access to beverages that met or did not meet the standards. Results Of 115 schools, 89.6% met the competitive beverage nutrition standards; 88.5% of elementary schools and 61.5% of middle schools did not sell competitive beverages. Nutrition standards were met in 79.2% of high schools; 37.5% did not sell any competitive beverages, and 41.7% sold only beverages meeting the standards. Overall, 85.5% of students attended schools meeting the standards. Only 4.0% of students had access to sugar-sweetened beverages. Conclusion A comprehensive, district-wide competitive beverage policy with implementation support can translate into a sustained healthful environment in public schools. PMID:26940299

  10. The dysexecutive syndrome associated with ischaemic vascular disease and related subcortical neuropathology: a Boston process approach.

    Science.gov (United States)

    Lamar, Melissa; Price, Cate C; Giovannetti, Tania; Swenson, Rod; Libon, David J

    2010-01-01

    The introduction of diagnostic criteria for vascular dementia has helped to re-define the impact of various subcortical neuropathologies on aging; however, state-of-the-art neuroimaging techniques and autopsy studies suggest that not all structural brain alterations associated with vascular dementia are exclusive to this neurodegenerative process alone. Thus, a detailed analysis of the cognitive phenotype associated with ischaemic vascular disease is key to our understanding of subcortical neuropathology and its associated behaviors. Over the past twenty years, we have operationally defined this cognitive phenotype using the Boston Process Approach to neuropsychological assessment. This has led to both an empirical, as well as a theoretical understanding of three core constructs related to the dysexecutive syndrome associated with ischaemic vascular disease affecting periventricular and deep white matter as well as subcortical structures connecting these regions with the prefrontal cortex. Thus, difficulties with mental set, cognitive control and mental manipulation negatively impact executive functioning. This review will outline the subtle markers underlying this prefrontal dysfunction, i.e., the dysexecutive phenotype, associated with ischaemic vascular disease and relate it to fundamental impairments of gating subserved by basal ganglia-thalamic pathways within and across various dementia syndromes.

  11. The Dysexecutive Syndrome Associated with Ischaemic Vascular Disease and Related Subcortical Neuropathology: A Boston Process Approach

    Directory of Open Access Journals (Sweden)

    Melissa Lamar

    2010-01-01

    Full Text Available The introduction of diagnostic criteria for vascular dementia has helped to re-define the impact of various subcortical neuropathologies on aging; however, state-of-the-art neuroimaging techniques and autopsy studies suggest that not all structural brain alterations associated with vascular dementia are exclusive to this neurodegenerative process alone. Thus, a detailed analysis of the cognitive phenotype associated with ischaemic vascular disease is key to our understanding of subcortical neuropathology and its associated behaviors. Over the past twenty years, we have operationally defined this cognitive phenotype using the Boston Process Approach to neuropsychological assessment. This has led to both an empirical, as well as a theoretical understanding of three core constructs related to the dysexecutive syndrome associated with ischaemic vascular disease affecting periventricular and deep white matter as well as subcortical structures connecting these regions with the prefrontal cortex. Thus, difficulties with mental set, cognitive control and mental manipulation negatively impact executive functioning. This review will outline the subtle markers underlying this prefrontal dysfunction, i.e., the dysexecutive phenotype, associated with ischaemic vascular disease and relate it to fundamental impairments of gating subserved by basal ganglia-thalamic pathways within and across various dementia syndromes.

  12. In vivo operation of the Boston 15-channel wireless subretinal visual prosthesis

    Science.gov (United States)

    Shire, Douglas B.; Doyle, Patrick; Kelly, Shawn K.; Gingerich, Marcus D.; Chen, Jinghua; Cogan, Stuart F.; Drohan, William A.; Mendoza, Oscar; Theogarajan, Luke; Wyatt, John; Rizzo, Joseph F.

    2010-02-01

    This presentation concerns the engineering development of the Boston visual prosthesis for restoring useful vision to patients blind with degenerative retinal disease. A miniaturized, hermetically-encased, 15-channel wirelessly-operated retinal prosthetic was developed for implantation and pre-clinical studies in Yucatan mini-pig animal models. The prosthesis conforms to the eye and drives a microfabricated polyimide stimulating electrode array having sputtered iridium oxide electrodes. This array is implanted into the subretinal space using a specially-designed ab externo surgical technique; the bulk of the prosthesis is on the surface of the sclera. The implanted device includes a hermetic titanium case containing a 15-channel stimulator chip; secondary power/data receiving coils surround the cornea. Long-term in vitro pulse testing was also performed on the electrodes to ensure their stability over years of operation. Assemblies were first tested in vitro to verify wireless operation of the system in biological saline using a custom RF transmitter circuit and primary coils. Stimulation pulse strength, duration and frequency were programmed wirelessly using a computer with a custom graphical user interface. Operation of the retinal implant was verified in vivo in 3 minipigs for more than three months by measuring stimulus artifacts on the eye surface using contact lens electrodes.

  13. A Community-Level Sodium Reduction Intervention, Boston, 2013-2015.

    Science.gov (United States)

    Brooks, Carolyn J; Barrett, Jessica; Daly, James; Lee, Rebekka; Blanding, Nineequa; McHugh, Anne; Williams, David; Gortmaker, Steven

    2017-12-01

    To evaluate a community-level sodium-reduction intervention in Boston, Massachusetts. Reducing sodium in the food offerings of community settings may help reduce hypertension disparities. We examined changes in the proportion of prepackaged foods with greater than 200 milligrams of sodium in 7 hospitals, 8 YMCAs, 4 community health centers, and 2 organizations serving homeless populations. Research assistants documented prepackaged items in cafeterias, kiosks, and vending machines before and after the intervention (2013-2015). We assessed intervention change via linear mixed models accounting for repeated observations. There were 161 access points at baseline (4347 facings) and 171 (4996 facings) at follow-up. The percentage of prepackaged products with greater than 200 milligrams of sodium decreased from 29.0% at baseline to 21.5% at follow-up (P = .003). Changes were driven by improvements in hospital cafeterias and kiosks (P = .003). The percentage of products with greater than 200 milligrams of sodium in YMCA vending decreased 58% (from 27.2% to 11.5%; P = .017); other organizations had nonsignificant declines. We found modest reductions in the percentage of higher-sodium prepackaged products across community institutions. Community-level interventions may increase availability of lower-sodium products in the food supply.

  14. Corneal Melt after Boston Keratoprosthesis: Clinical Presentation, Management, Outcomes and Risk Factor Analysis.

    Science.gov (United States)

    Bouhout, Soumaya; Robert, Marie-Claude; Deli, Sousans; Harissi-Dagher, Mona

    2017-01-12

    To determine the presentation, risk factors, and outcomes of keratolysis after Boston type I keratoprosthesis (B-KPro). Retrospective chart review. A total of 16 (14%) of the 110 eyes (96 patients) which underwent B-KPro implantation developed keratolysis at an average 20 ± 11 months. Retroprosthetic membrane (RPM), infectious keratitis, and corneal dellen were identified in 31%, 25%, and 13% of corneal melts, respectively. Five eyes had keratolysis without a readily identifiable cause. RPM (odds-ratio, OR = 4.4, p = 0.02) and infectious keratitis (OR = 17.6, p<0.0005) were confirmed as significant risk factors. Retinal detachment (p = 0.001) and choroidal detachment (p = 0.003) were more common in eyes with keratolysis. Management included B-KPro removal or exchange (n = 7), amniotic membrane transplantation (n = 1), tectonic corneal transplantation (n = 2), medical treatment (n = 4), and observation (n = 2). The risk of keratolysis following B-Kpro increases with the development of RPM and infectious keratitis. Patients with keratolysis had higher complication rates and should receive rigorous monitoring.

  15. Outcomes After Auro Keratoprosthesis Implantation: A Low-Cost Design Based on the Boston Keratoprosthesis.

    Science.gov (United States)

    Venugopal, Anitha; Rathi, Harshal; Rengappa, Ramakrishnan; Ravindran, Meenakshi; Raman, Ramalakshmy

    2016-10-01

    To evaluate outcomes after Auro keratoprosthesis (kpro) implantation. Retrospective observational case series. The records of all patients who were implanted with Auro kpro from December 2012 to August 2015 at a single institute were retrospectively analyzed to evaluate preoperative characteristics, postoperative outcomes, and complications. Fifteen cases were included in the study. Failed graft was the most common indication for the surgery (n = 14; 93.3%). The mean BCVA (Log MAR) improved from 2.20 ± 0.43 in the preoperative period to 1.46 ± 1.12 (P = 0.0247) at the mean final follow-up of 13.5 months. The best corrected visual acuity (BCVA) improved to 20/200 or better in 9 patients (60%) at the final follow-up. Postoperative complications included retroprosthetic membrane formation (n = 7; 46.7 %), graft infection (n = 4; 26.7%), sterile corneal melt (n = 3; 20%), and spontaneous optic extrusion (n = 1; 6.7%). Eleven patients retained prosthesis at the final follow-up (retention rate = 73.3%). Auro kpro seems to be effective in treating end-stage corneal diseases. The outcomes are comparable to Boston kpro in terms of visual acuity, postoperative complications, and retention rates.

  16. Boston keratoprosthesis – Clinical outcomes with wider geographic use and expanding indications – A systematic review

    Science.gov (United States)

    Al Arfaj, Khalid

    2015-01-01

    Over 2 decades of research, several design modifications, and improvements in post-operative management have made Boston keratoprosthesis (B-KPro) a viable option for patients with corneal blindness for whom traditional keratoplasty procedure has a very low probability of success. In this systematic review, we examined the indications, visual outcomes, complications and retention rate of the literature published in the past 10 years (2005–2014). While most of the studies report smaller datasets (typically <50 eyes), some of the recent multicenter studies have reported large datasets (up to 300 eyes). Most of the literature is published from the US; however, last few years have witnessed some papers reporting the successful use of B-Kpro from developing countries or arid climatic conditions (such as the Kingdom of Saudi Arabia). Due to differences in the causes of corneal blindness in different geographic regions, newer indications for B-Kpro are emerging (e.g. trachoma). Additionally, improving clinical outcomes and increasing surgeon confidence have also expanded indications to include cases of unilateral visual impairment and paediatric age. We observed that there is growing body of evidence of successful clinical use of B-KPro; however, financial challenges, lack of trained surgeons, shortage of donor corneas must be overcome to improve accessibility of B-KPro. PMID:26155082

  17. Anterior segment optical coherence tomography for the quantitative evaluation of the anterior segment following Boston keratoprosthesis.

    Directory of Open Access Journals (Sweden)

    Joann J Kang

    Full Text Available OBJECTIVE: To quantitatively evaluate the anterior segment using anterior segment optical coherence tomography (AS-OCT following Boston keratoprosthesis type 1. METHODS: A retrospective study consisted of AS-OCT imaging at a single time point postoperatively in 52 eyes. Main outcomes measures include anatomical and functional anterior chamber depth (ACD, angle (ACA and peripheral and proximal synechiae. RESULTS: The mean time point of imaging was 19.3 months postoperatively. Average anatomical and functional ACD was 2.0 and 0.21 mm respectively, and mean ACA ranged from 2.5° to 6.14° in representative meridians. An average of 8.7 clock hours of angle closure was observed in the 25 eyes in which all meridians were imaged. The majority of eyes showed peripheral (86.5% and proximal (67.3% synechiae. CONCLUSIONS: AS-OCT is a useful tool for quantitative evaluation of anterior segment and angle after keratoprosthesis, which is otherwise poorly visible. The majority of eyes showed shallow ACD, extensive angle closure and synechiae formation.

  18. Boston keratoprosthesis - Clinical outcomes with wider geographic use and expanding indications - A systematic review.

    Science.gov (United States)

    Al Arfaj, Khalid

    2015-01-01

    Over 2 decades of research, several design modifications, and improvements in post-operative management have made Boston keratoprosthesis (B-KPro) a viable option for patients with corneal blindness for whom traditional keratoplasty procedure has a very low probability of success. In this systematic review, we examined the indications, visual outcomes, complications and retention rate of the literature published in the past 10 years (2005-2014). While most of the studies report smaller datasets (typically <50 eyes), some of the recent multicenter studies have reported large datasets (up to 300 eyes). Most of the literature is published from the US; however, last few years have witnessed some papers reporting the successful use of B-Kpro from developing countries or arid climatic conditions (such as the Kingdom of Saudi Arabia). Due to differences in the causes of corneal blindness in different geographic regions, newer indications for B-Kpro are emerging (e.g. trachoma). Additionally, improving clinical outcomes and increasing surgeon confidence have also expanded indications to include cases of unilateral visual impairment and paediatric age. We observed that there is growing body of evidence of successful clinical use of B-KPro; however, financial challenges, lack of trained surgeons, shortage of donor corneas must be overcome to improve accessibility of B-KPro.

  19. Anterior Segment Optical Coherence Tomography for the Quantitative Evaluation of the Anterior Segment Following Boston Keratoprosthesis

    Science.gov (United States)

    Kang, Joann J.; Allemann, Norma; Vajaranant, Thasarat; de la Cruz, Jose; Cortina, Maria Soledad

    2013-01-01

    Objective To quantitatively evaluate the anterior segment using anterior segment optical coherence tomography (AS-OCT) following Boston keratoprosthesis type 1. Methods A retrospective study consisted of AS-OCT imaging at a single time point postoperatively in 52 eyes. Main outcomes measures include anatomical and functional anterior chamber depth (ACD), angle (ACA) and peripheral and proximal synechiae. Results The mean time point of imaging was 19.3 months postoperatively. Average anatomical and functional ACD was 2.0 and 0.21 mm respectively, and mean ACA ranged from 2.5° to 6.14° in representative meridians. An average of 8.7 clock hours of angle closure was observed in the 25 eyes in which all meridians were imaged. The majority of eyes showed peripheral (86.5%) and proximal (67.3%) synechiae. Conclusions AS-OCT is a useful tool for quantitative evaluation of anterior segment and angle after keratoprosthesis, which is otherwise poorly visible. The majority of eyes showed shallow ACD, extensive angle closure and synechiae formation. PMID:23940621

  20. Paternal involvement and support and risk of preterm birth: findings from the Boston birth cohort.

    Science.gov (United States)

    Surkan, Pamela J; Dong, Liming; Ji, Yuelong; Hong, Xiumei; Ji, Hongkai; Kimmel, Mary; Tang, Wan-Yee; Wang, Xiaobin

    2017-11-16

    To investigate to what extent paternal involvement and support during pregnancy were associated with preterm (PTB) and small-for-gestational age (SGA) births. Using data from the Boston Birth Cohort (n = 7047), multiple logistic regression models were performed to estimate the log odds of either PTB or SGA birth, with paternal involvement, paternal social support, and family and friend social support variables as the primary independent variables. About 10% of participating mothers reported their husbands not being involved or supportive during their pregnancies. Lack of paternal involvement was associated with 21% higher risk of PTB (OR = 1.21, 95% CI: 1.01-1.45). Similarly, lack of paternal support was borderline associated with PTB (OR = 1.13, 95% CI: 0.94-1.35). Also marginally significant, lack of paternal involvement (OR = 1.18, 95% CI: 0.95-1.47) and father's support (OR = 1.19, 95% CI: 0.96-1.48) were associated with higher odds of SGA birth. No associations were found between familial and friend support during pregnancy and PTB or SGA. Among predominantly low-income African Americans, lack of paternal involvement and lack of paternal support during pregnancy were associated with an increased risk of PTB, and suggestive of SGA birth. These findings, if confirmed in future research, underscore the important role a father can play in reducing PTB and/or SGA.

  1. Chronic traumatic encephalopathy: contributions from the Boston University Center for the Study of Traumatic Encephalopathy.

    Science.gov (United States)

    Riley, David O; Robbins, Clifford A; Cantu, Robert C; Stern, Robert A

    2015-01-01

    Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease associated with repetitive brain trauma (RBT). Initially described in boxers, CTE has now been found in other contact sport athletes with a history of RBT. In recent years, there has been tremendous media attention regarding CTE, primarily because of the deaths of high profile American football players who were found to have CTE upon neuropathological examination. However, the study of CTE remains in its infancy. This review focuses on research from the Centre for the Study of Traumatic Encephalopathy (CSTE) at Boston University. This study reviews the formation of the CSTE, major CSTE publications and current ongoing research projects at the CSTE. The neuropathology of CTE has been well-described. Current research focuses on: methods of diagnosing the disease during life (including the development of biomarkers), examination of CTE risk factors (including genetic susceptibility and head impact exposure variables); description of the clinical presentation of CTE; development of research diagnostic criteria for Traumatic Encephalopathy Syndrome; and assessment of mechanism and pathogenesis. Current research at the BU CSTE is aimed at increasing understanding of the long-term consequences of repetitive head impacts and attempting to begin to answer several of the unanswered questions regarding CTE.

  2. Performance of a Brazilian population sample in the Boston Diagnostic Aphasia Examination: A pilot study

    Directory of Open Access Journals (Sweden)

    M. Radanovic

    2002-03-01

    Full Text Available Brazilian researchers and health professionals often face the challenge of having to use tests developed in foreign languages and standardized for populations of other countries, especially in the fields of Neuropsychology and Neurolinguistics. This fact promotes a feeling that some scoring systems may be inadequate for our sociocultural reality. In the present study, we describe the performance of a Brazilian population sample submitted to a translated and adapted version of the Boston Diagnostic Aphasia Examination (BDAE. Sixty normal volunteers (21 men and 39 women, all Portuguese native speakers, ranging in age from 15 to 78 years (average 43.7 and with an educational level of 2 to 16 years (average 9.9, were tested using a translated and adapted Portuguese version of the BDAE. Cut-off scores are suggested for our population and the performance of the Brazilian sample is compared to that of American and Colombian samples, with the results being closely similar in all tasks. We also performed a correlation analysis between age, gender and educational level and the influence of these variables on the performance of the subjects. We found no statistically significant differences between genders. Educational level correlated positively with performance, especially in the subtests involving reading and writing. There was a negative correlation between age and performance in two subtests (Visual Confrontation Naming and Sentences to Dictation, but a coexisting effect of educational level could not be ruled out.

  3. Performance of a Brazilian population sample in the Boston Diagnostic Aphasia Examination: a pilot study.

    Science.gov (United States)

    Radanovic, M; Mansur, L L

    2002-03-01

    Brazilian researchers and health professionals often face the challenge of having to use tests developed in foreign languages and standardized for populations of other countries, especially in the fields of Neuropsychology and Neurolinguistics. This fact promotes a feeling that some scoring systems may be inadequate for our sociocultural reality. In the present study, we describe the performance of a Brazilian population sample submitted to a translated and adapted version of the Boston Diagnostic Aphasia Examination (BDAE). Sixty normal volunteers (21 men and 39 women), all Portuguese native speakers, ranging in age from 15 to 78 years (average 43.7) and with an educational level of 2 to 16 years (average 9.9), were tested using a translated and adapted Portuguese version of the BDAE. Cut-off scores are suggested for our population and the performance of the Brazilian sample is compared to that of American and Colombian samples, with the results being closely similar in all tasks. We also performed a correlation analysis between age, gender and educational level and the influence of these variables on the performance of the subjects. We found no statistically significant differences between genders. Educational level correlated positively with performance, especially in the subtests involving reading and writing. There was a negative correlation between age and performance in two subtests (Visual Confrontation Naming and Sentences to Dictation), but a coexisting effect of educational level could not be ruled out.

  4. Assessment of a Districtwide Policy on Availability of Competitive Beverages in Boston Public Schools, Massachusetts, 2013.

    Science.gov (United States)

    Mozaffarian, Rebecca S; Gortmaker, Steven L; Kenney, Erica L; Carter, Jill E; Howe, M Caitlin Westfall; Reiner, Jennifer F; Cradock, Angie L

    2016-03-03

    Competitive beverages are drinks sold outside of the federally reimbursable school meals program and include beverages sold in vending machines, a la carte lines, school stores, and snack bars. Competitive beverages include sugar-sweetened beverages, which are associated with overweight and obesity. We described competitive beverage availability 9 years after the introduction in 2004 of district-wide nutrition standards for competitive beverages sold in Boston Public Schools. In 2013, we documented types of competitive beverages sold in 115 schools. We collected nutrient data to determine compliance with the standards. We evaluated the extent to which schools met the competitive-beverage standards and calculated the percentage of students who had access to beverages that met or did not meet the standards. Of 115 schools, 89.6% met the competitive beverage nutrition standards; 88.5% of elementary schools and 61.5% of middle schools did not sell competitive beverages. Nutrition standards were met in 79.2% of high schools; 37.5% did not sell any competitive beverages, and 41.7% sold only beverages meeting the standards. Overall, 85.5% of students attended schools meeting the standards. Only 4.0% of students had access to sugar-sweetened beverages. A comprehensive, district-wide competitive beverage policy with implementation support can translate into a sustained healthful environment in public schools.

  5. The Boston Marathon bombings: a post-event review of the robust emergency response.

    Science.gov (United States)

    2013-07-01

    With as many as five level I trauma centers, Boston is well-positioned to mount an emergency response, but the two terrorist bombs that went off near the finish line of the city's annual marathon on April 15 put high levels of stress and demand on emergency personnel. In post-crisis reviews, hospital administrators say that all the emergency planning and drilling that they carry out on a regular basis was instrumental in helping them quickly care for nearly 200 victims while also securing their facilities at a time when the threat to the city was not well understood. Medical personnel working in tents on site at the marathon were able to respond to the injured quickly, while also giving area EDs a heads-up on what to expect. ED leaders report that a robust effort from the upper floors of their hospitals was critical in: helping them clear their EDs for incoming patients; establishing a security perimeter around the facilities to thoroughly check any people entering or leaving to guard against potential external threats; and focusing on improving how many extra staff show up to help during the crisis because it actually requires extra resources to manage the personnel.

  6. The Boston Marathon Bombings Mass Casualty Incident: One Emergency Department's Information Systems Challenges and Opportunities.

    Science.gov (United States)

    Landman, Adam; Teich, Jonathan M; Pruitt, Peter; Moore, Samantha E; Theriault, Jennifer; Dorisca, Elizabeth; Harris, Sheila; Crim, Heidi; Lurie, Nicole; Goralnick, Eric

    2015-07-01

    Emergency department (ED) information systems are designed to support efficient and safe emergency care. These same systems often play a critical role in disasters to facilitate real-time situation awareness, information management, and communication. In this article, we describe one ED's experiences with ED information systems during the April 2013 Boston Marathon bombings. During postevent debriefings, staff shared that our ED information systems and workflow did not optimally support this incident; we found challenges with our unidentified patient naming convention, real-time situational awareness of patient location, and documentation of assessments, orders, and procedures. As a result, before our next mass gathering event, we changed our unidentified patient naming convention to more clearly distinguish multiple, simultaneous, unidentified patients. We also made changes to the disaster registration workflow and enhanced roles and responsibilities for updating electronic systems. Health systems should conduct disaster drills using their ED information systems to identify inefficiencies before an actual incident. ED information systems may require enhancements to better support disasters. Newer technologies, such as radiofrequency identification, could further improve disaster information management and communication but require careful evaluation and implementation into daily ED workflow. Copyright © 2014 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

  7. Blast Injuries: From Improvised Explosive Device Blasts to the Boston Marathon Bombing.

    Science.gov (United States)

    Singh, Ajay K; Ditkofsky, Noah G; York, John D; Abujudeh, Hani H; Avery, Laura A; Brunner, John F; Sodickson, Aaron D; Lev, Michael H

    2016-01-01

    Although most trauma centers have experience with the imaging and management of gunshot wounds, in most regions blast wounds such as the ones encountered in terrorist attacks with the use of improvised explosive devices (IEDs) are infrequently encountered outside the battlefield. As global terrorism becomes a greater concern, it is important that radiologists, particularly those working in urban trauma centers, be aware of the mechanisms of injury and the spectrum of primary, secondary, tertiary, and quaternary blast injury patterns. Primary blast injuries are caused by barotrauma from the initial increased pressure of the explosive detonation and the rarefaction of the atmosphere immediately afterward. Secondary blast injuries are caused by debris carried by the blast wind and most often result in penetrating trauma from small shrapnel. Tertiary blast injuries are caused by the physical displacement of the victim and the wide variety of blunt or penetrating trauma sustained as a result of the patient impacting immovable objects such as surrounding cars, walls, or fences. Quaternary blast injuries include all other injuries, such as burns, crush injuries, and inhalational injuries. Radiography is considered the initial imaging modality for assessment of shrapnel and fractures. Computed tomography is the optimal test to assess penetrating chest, abdominal, and head trauma. The mechanism of blast injuries and the imaging experience of the victims of the Boston Marathon bombing are detailed, as well as musculoskeletal, neurologic, gastrointestinal, and pulmonary injury patterns from blast injuries. ©RSNA, 2016.

  8. Leadership During the Boston Marathon Bombings: A Qualitative After-Action Review.

    Science.gov (United States)

    Goralnick, Eric; Halpern, Pinchas; Loo, Stephanie; Gates, Jonathan; Biddinger, Paul; Fisher, John; Velmahos, George; Chung, Sarita; Mooney, David; Brown, Calvin; Barnewolt, Brien; Burke, Peter; Gupta, Alok; Ulrich, Andrew; Hojman, Horacio; McNulty, Eric; Dorn, Barry; Marcus, Leonard; Peleg, Kobi

    2015-10-01

    On April 15, 2013, two improvised explosive devices (IEDs) exploded at the Boston Marathon and 264 patients were treated at 26 hospitals in the aftermath. Despite the extent of injuries sustained by victims, there was no subsequent mortality for those treated in hospitals. Leadership decisions and actions in major trauma centers were a critical factor in this response. The objective of this investigation was to describe and characterize organizational dynamics and leadership themes immediately after the bombings by utilizing a novel structured sequential qualitative approach consisting of a focus group followed by subsequent detailed interviews and combined expert analysis. Across physician leaders representing 7 hospitals, several leadership and management themes emerged from our analysis: communications and volunteer surges, flexibility, the challenge of technology, and command versus collaboration. Disasters provide a distinctive context in which to study the robustness and resilience of response systems. Therefore, in the aftermath of a large-scale crisis, every effort should be invested in forming a coalition and collecting critical lessons so they can be shared and incorporated into best practices and preparations. Novel communication strategies, flexible leadership structures, and improved information systems will be necessary to reduce morbidity and mortality during future events.

  9. Emotional intelligence in the operating room: analysis from the Boston Marathon bombing.

    Science.gov (United States)

    Chang, Beverly P; Vacanti, Joshua C; Michaud, Yvonne; Flanagan, Hugh; Urman, Richard D

    2014-01-01

    The Boston Marathon terrorist bombing that occurred on April 15, 2013 illustrates the importance of a cohesive, efficient management for the operating room and perioperative services. Conceptually, emotional intelligence (EI) is a form of social intelligence used by individuals in leadership positions to monitor the feelings and emotions of their team while implementing a strategic plan. To describe the experience of caring for victims of the bombing at a large tertiary care center and provide examples demonstrating the importance of EI and its role in the management of patient flow and overall care. A retrospective review of trauma data was performed. Data regarding patient flow, treatment types, treatment times, and outcomes were gathered from the hospital's electronic tracking system and subsequently analyzed. Analyses were performed to aggregate the data, identify trends, and describe the medical care. Immediately following the bombing, a total of 35 patients were brought to the emergency department (ED) with injuries requiring immediate medical attention. 10 of these patients went directly to the operating room on arrival to the hospital. The first victim was in an operating room within 21 minutes after arrival to the ED. The application of EI in managerial decisions helped to ensure smooth transitions for victims throughout all stages of their perioperative care. EI provided the fundamental groundwork that allowed the operating room manager and nurse leaders to establish the calm and coordinated leadership that facilitated patient care and teamwork.

  10. Pharmacy Response to the Boston Marathon Bombings at a Tertiary Academic Medical Center.

    Science.gov (United States)

    Sylvester, Katelyn W; Rocchio, Megan A; Belisle, Caryn; Matta, Lina; Goralnick, Eric

    2014-08-01

    Effective crisis response requires multidisciplinary communication and rapid action. Our goals are to highlight the experience of a pharmacy department's response to the 2013 Boston Marathon bombing, to discuss the role of the pharmacist in a crisis response, and to identify potential learning opportunities for a future mass casualty event. Our initial response targeted 3 general areas: staffing, supplies, and communication. Pharmacist and technician staffing was increased throughout the hospital, with a 6-fold increase of pharmacists to the emergency department (ED). To ensure adequate supplies were available, inventory on the ED automatic dispensing cabinets (ADC) was assessed for vaccines, antibiotics, and vasoactive medications. ED pharmacists prepared emergent intravenous medications in the ED while the sterile products room bolstered our supply of intravenous medications for patients in the ED and operating room. Overall, there was a 33% increase in the number of ADC transactions, with pharmacists representing 28% of all ADC transactions. To optimize communication, we formulated a comprehensive plan for the timely dissemination of information to the entire pharmacy staff. A mass casualty event is a rare occasion, and it is vital for the pharmacy department to respond rapidly with little notification. The role of a pharmacist is unique and can most effectively triage drug information and medication distribution, especially during times of high demand and high stress. © The Author(s) 2014.

  11. Serum 25-Hydroxyvitamin D Levels Among Boston Trainee Doctors in Winter

    Directory of Open Access Journals (Sweden)

    Sunday Clark

    2012-03-01

    Full Text Available As indoor workers, trainee doctors may be at risk for inadequate vitamin D. All trainee doctors (residents in a Boston pediatric training program (residency were invited to complete a survey, and undergo testing for serum 25-hydroxyvitamin D [25(OHD], PTH, and calcium during a 3-week period in March 2010. We examined the association between resident characteristics and serum 25(OHD using Chi2 and Kruskal-Wallis test and multivariable linear and logistic regression. Of the 119 residents, 102 (86% participated. Although the mean serum 25(OHD level was 67 nmol/L (±26, 25 (25% had a level < 50 nmol/L and 3 (3% residents had levels < 25 nmol/L. In the multivariable model, factors associated with 25(OHD levels were: female sex (β 12.7, 95% CI 3.6, 21.7, white race (β 21.7, 95% CI 11.7, 31.7, travel to more equatorial latitudes during the past 3 months (β 6.3, 95% CI 2.0, 10.5 and higher daily intake of vitamin D (β 1.1, 95% CI 0.04, 2.1. Although one in four residents in our study had a serum 25(OHD < 50 nmol/L, all of them would have been missed using current Centers for Medicare and Medicaid Services (CMS screening guidelines. The use of traditional risk factors appears insufficient to identify low vitamin D in indoor workers at northern latitudes.

  12. Iodine status and thyroid function of Boston-area vegetarians and vegans.

    Science.gov (United States)

    Leung, Angela M; Lamar, Andrew; He, Xuemei; Braverman, Lewis E; Pearce, Elizabeth N

    2011-08-01

    Adequate dietary iodine is required for normal thyroid function. The iodine status and thyroid function of U.S. vegetarians and vegans have not been previously studied. Environmental perchlorate and thiocyanate (inhibitors of thyroid iodine uptake) exposures may adversely affect thyroid function. The objective of the study was to assess the iodine status and thyroid function of U.S. vegetarians (consume plant based products, eggs, milk; abstain from meat, poultry, fish, shellfish) and vegans (avoid all animal products) and whether these may be affected by environmental perchlorate and thiocyanate exposures. This was a cross-sectional assessment of urinary iodine, perchlorate, and thiocyanate concentrations and serum thyroid function in Boston-area vegetarians and vegans. One hundred forty-one subjects (78 vegetarians, 63 vegans) were recruited; one vegan was excluded. Median urinary iodine concentration of vegans (78.5 μg/liter; range 6.8-964.7 μg/liter) was lower than vegetarians (147.0 μg/liter; range 9.3-778.6 μg/liter) (P vegans (630 μg/liter; range 108-3085 μg/liter) was higher than vegetarians (341 μg/liter; range 31-1963 μg/liter) (P vegans may be at risk for low iodine intake, and vegan women of child-bearing age should supplement with 150 μg iodine daily. Environmental perchlorate and thiocyanate exposures are not associated with thyroid dysfunction in these groups.

  13. Clients’ experiences of the Boston Psychiatric Rehabilitation Approach: A qualitative study

    Directory of Open Access Journals (Sweden)

    Henrika Jormfeldt

    2014-04-01

    Full Text Available The Boston Psychiatric Rehabilitation Approach (BPR is person-centered and characterized by being based entirely on the individual's unique needs and preferences in the areas of working, learning, social contacts, and living environment. Nevertheless, the person-centered approach is lacking firm evidence regarding outcomes, and empirical studies regarding clients’ experiences of this particular model are needed. A qualitative content analysis of 10 transcribed semistructured individual interviews was used to describe and explore clients’ experiences of the BPR during an implementation project in Sweden. The findings from the interviews could be summarized in “A sense of being in communion with self and others” theme, consisting of three categories: increased self-understanding, getting new perspectives, and being in a trusting relationship. The results showed that clients do not always recognize nor are able to verbalize their goals before they have been given the possibility to reflect their thoughts in collaboration with a trusted person. The guidelines of the approach are intended to support the clients’ ability to participate in decision making regarding their own care. More research about efficacy of different rehabilitation approaches and exploration of fidelity to guidelines of rehabilitation programs are required.

  14. Relatives’ experiences of the Boston Psychiatric Rehabilitation approach: A qualitative study

    Directory of Open Access Journals (Sweden)

    Henrika Jormfeldt

    2014-04-01

    Full Text Available The Boston Psychiatric Rehabilitation (BPR approach is individualized and characterized by being based entirely on the individual's unique needs and preferences in the areas of working, learning, social contacts, and living environment. Relatives of clients in mental health services influence the client's possibilities for recovery by their everyday relationship. Relatives have, however, traditionally had a subordinated role in the care of their mentally ill family member. The perspective of relatives is an important aspect in the development of new approaches to psychiatric rehabilitation. The purpose of this study was thus to describe and explore relatives’ experiences of the BPR approach. Ten relatives of clients in mental health services taking part in the BPR were interviewed. The interviews were transcribed and analyzed with a qualitative content analysis method to explore relatives’ experiences of the BPR intervention in a county in Sweden. The findings from the interviews could be summarized in the theme “To meet the clients’ needs” consisting of three categories: “Dependence on staffs’ competence,” “Responsibility for user involvement,” and “The necessity for coordination between authorities and caregivers.” The findings suggest that relatives may contribute with important information about clients’ needs related to outcome of care. Relatives’ perspectives may be of importance in future development of BPR. Further research about the relatives’ role in psychiatric rehabilitation is needed as well as studies that compare different kinds of psychiatric rehabilitation from the perspective of relatives.

  15. Boston children's hospital community asthma initiative: Five-year cost analyses of a home visiting program.

    Science.gov (United States)

    Bhaumik, Urmi; Sommer, Susan J; Giller-Leinwohl, Judith; Norris, Kerri; Tsopelas, Lindsay; Nethersole, Shari; Woods, Elizabeth R

    2017-03-01

    To evaluate the costs and benefits of the Boston Children's Hospital Community Asthma Initiative (CAI) through reduction of Emergency Department (ED) visits and hospitalizations for the full pilot-phase program participants. A cost-benefit analyses was conducted using hospital administrative data to determine an adjusted Return on Investment (ROI): on all 268 patients enrolled in the CAI program during the 33-month pilot program phase of CAI intervention between October 1, 2005 and June 30, 2008 using a comparison group of 818 patients from a similar cohort in neighboring ZIP codes without CAI intervention. Cost data through June 30, 2013 were used to examine cost changes and calculate an adjusted ROI over a 5-year post-intervention period. CAI patients had a cost reduction greater than the comparison group of $1,216 in Year 1 (P = 0.001), $1,320 in Year 2 (P management programs can decrease the incidence of costly hospitalizations and ED visits from asthma. An ROI of greater than one, as found in this cost analysis, supports the business case for the provision of community-based asthma services as part of patient-centered medical homes and Accountable Care Organizations.

  16. Infliximab after Boston Keratoprosthesis in Stevens-Johnson Syndrome: An Update.

    Science.gov (United States)

    Robert, Marie-Claude; Črnej, Alja; Shen, Lucy Q; Papaliodis, George N; Dana, Reza; Foster, C Stephen; Chodosh, James; Dohlman, Claes H

    2017-06-01

    To report our experience using intravenous infliximab for the treatment of tissue melt after Boston keratoprosthesis (B-KPro) types I and II in patients with autoimmune disease. Case series. We identified four patients who were treated with intravenous infliximab in the context of tissue melt after B-KPro. Stevens-Johnson syndrome-associated corneal blindness was the primary surgical indication for B-KPro implantation in all patients. Two patients received a B-KPro type I and two patients received a B-KPro type II. The patients received intravenous infliximab for skin retraction around B-KPro type II, melting of the carrier graft or leak. Treatment resulted in a dramatic decrease in inflammation and, in some cases, arrest of the melting process. Cost and patient adherence were limiting factors to pursuing infliximab therapy. In addition, one patient developed infusion reactions. Intravenous infliximab may be considered as globe- and sight-saving therapy for tissue melt after B-KPro.

  17. As empresas em sociedades contemporâneas: a responsabilidade social no Norte e no Sul

    Directory of Open Access Journals (Sweden)

    Paola Cappellin

    Full Text Available Neste artigo a difusão do lema da responsabilidade social é resgatada pela analise de três percursos internacionais: EUA, Brasil e União Européia. No primeiro caso, a vasta literatura sociológica americana relata as preocupações e as pressões de diferentes atores sociais dirigidas às empresas americanas, ao longo dos anos 1960. No Brasil, as primeiras elaborações provêm de associações empresariais nos meados dos anos 60 e se ampliam justo quando a sociedade, no fim dos anos 1990, demanda prosseguir na direção a integrar o compromisso da aplicação das normas e direitos do trabalho. Na União Européia, o lema da responsabilidade social é introduzido nos finais dos anos 1990 envolvendo o compromisso de fazer retroagir a alta taxa de desemprego estrutural. Na última seção, a análise comparativa internacional sugere recompor o quadro dos diversos conteúdos da responsabilidade social a partir da grande questão que está em debate nas sociedades: recompor o compromisso de fortalecimento do vínculo de emprego como fonte de cidadania social.

  18. Ensino superior em administração entre os anos 1940 e 1950: uma discussão a partir dos acordos de cooperação Brasil-Estados Unidos

    Directory of Open Access Journals (Sweden)

    Amon Narciso de Barros

    Full Text Available O presente trabalho tem como objetivo discutir o desenvolvimento dos cursos superiores em Administração no Brasil entre os anos 1940 e 1950 a partir dos acordos de cooperação entre Brasil e EUA. Inicialmente discutimos brevemente a metodologia utilizada para coleta dos dados e, em seguida, apresentamos uma discussão sobre as relações bilaterais entre os países. Posteriormente tecemos considerações sobre os cursos superiores em Administração que contaram com o apoio estadunidense, além de refletirmos sobre os próprios acordos. Concluímos que a dita "americanização" da Administração no Brasil tem raízes profundas e que, para que um saber mais autoconsciente seja construído e fortalecido, devemos refletir sobre a constituição da própria área, sobre como as influências de modelos estrangeiros são recebidas e articuladas. Por fim, sugerimos que futuras pesquisas poderiam aprofundar as discussões realizadas, ao fazer estudos específicos sobre a história dos cursos superiores em Administração brasileiros, especialmente os que participaram de acordos com outras instituições.

  19. Ambulatory infusional cancer chemotherapy: nursing role in patient management. The Cancer Center of Boston.

    Science.gov (United States)

    Moore, C; Strong, D; Childress, J; Fougere, B; Gotthardt, S

    1996-01-01

    The role of nursing in infusional cancer chemotherapy (ICC) may vary depending on the practice setting. Nurses in free-standing centers and office practices perform many duties that nurses in other facilities may not, because of the lack of many of the supports that benefit hospitals with their multidepartmental and hierarchical structures. Nurses function collaboratively with physicians in the planning and the implementation of patient treatment. Patient-related nursing responsibilities include patient/family education, drug preparation and administration, patient assessment for treatment toxicity, recognition and management of complications related to the catheter or infusion device, and telephone triage. Other duties more removed from patient care might include inventory management, research data collection and management, quality assurance and improvement, compliance with regulatory issues, and a myriad of other responsibilities. The transition of patient care to the outpatient setting has broadened the scope of nursing to include nonpatient care responsibilities due to financial constraints brought about by health care reform, changes in reimbursement patterns, and overhead required to maintain and deliver quality patient care. As a result of nursing responsibilities, it becomes paramount that the aforementioned constructs for program support are in place and that all nurses are consistently trained and have a template to follow for patient treatment and management. Nursing ability to perform patient-related tasks should be proven by formal written and practical competencies repeated annually and as procedural changes are implemented. The paragraphs to follow suggest nursing management of patients receiving ICC using a model developed at The Cancer Center of Boston (TCC).

  20. Utility of a dedicated pediatric cardiac anticoagulation program: the Boston Children's Hospital experience.

    Science.gov (United States)

    Murray, Jenna M; Hellinger, Amy; Dionne, Roger; Brown, Loren; Galvin, Rosemary; Griggs, Suzanne; Mittler, Karen; Harney, Kathy; Manzi, Shannon; VanderPluym, Christina; Baker, Annette; O'Brien, Patricia; O'Connell, Cheryl; Almond, Christopher S

    2015-04-01

    Congenital heart disease is the leading cause of stroke in children. Warfarin therapy can be difficult to manage safely in this population because of its narrow therapeutic index, multiple drug and dietary interactions, small patient size, high-risk cardiac indications, and lack of data to support anticoagulation recommendations. We sought to describe our institution's effort to develop a dedicated cardiac anticoagulation service to address the special needs of this population and to review the literature. In 2009, in response to Joint Commission National Patient Safety Goals for Anticoagulation, Boston Children's Hospital created a dedicated pediatric Cardiac Anticoagulation Monitoring Program (CAMP). The primary purpose was to provide centralized management of outpatient anticoagulation to cardiac patients, to serve as a disease-specific resource to families and providers, and to devise strategies to evolve clinical care with rapidly emerging trends in anticoagulation care. Over 5 years the CAMP Service, staffed by a primary pediatric cardiology attending, a full-time nurse practitioner, and administrative assistant with dedicated support from pharmacy and nutrition, has enrolled over 240 patients ranging in age from 5 months to 55 years. The most common indications include a prosthetic valve (34 %), Fontan prophylaxis (20 %), atrial arrhythmias (11 %), cardiomyopathy (10 %), Kawasaki disease (7 %), and a ventricular assist device (2 %). A patient-centered multi-disciplinary cardiac anticoagulation clinic was created in 2012. Overall program international normalized ratio (INR) time in therapeutic range (TTR) is favorable at 67 % (81 % with a 0.2 margin) and has improved steadily over 5 years. Pediatric-specific guidelines for VKOR1 and CYP2C9 pharmacogenomics testing, procedural bridging with enoxaparin, novel anticoagulant use, and quality metrics have been developed. Program satisfaction is rated highly among families and providers. A dedicated pediatric

  1. The Boston Children's Hospital Academy: Development and Initial Assessment of a Hospital-Based Teaching Academy.

    Science.gov (United States)

    Gooding, Holly C; McCarty, Caitlin; Millson, Rebecca; Jiang, Hungyu; Armstrong, Elizabeth; Leichtner, Alan M

    2016-01-12

    Medical education academies play an important role in the recognition and career advancement of educators. However, hospital-based clinical faculty have unique professional development needs that may not be met by medical-school-based academies. The Boston Children's Hospital Academy was founded in 2008 to serve the needs of its clinician-educators. It was open to junior faculty scholars and to senior faculty scholars and mentors, including interprofessional educators. To maintain membership, individuals must propose and work toward an education project or serve as a project mentor. In 2012, a survey was sent to all members, and annual project reports were reviewed to assess the academy's impact. Sixty-five members completed the survey. The majority agreed that the academy created a community of educators, provided opportunities for networking and scholarship, contributed to their personal identity as an educator, and led to recognition by their chief. Projects addressed curriculum development, faculty development, learner assessment, program assessment, and resource development. They largely focused on graduate medical education and on patient safety and quality. During their tenure in the academy (mean length of membership = 2.4 years), members produced an average of 4.4 education presentations and 1.9 education publications, and 11 members were promoted. A hospital-based academy provides opportunities for interprofessional faculty development. Next steps include increasing interprofessional membership, wider dissemination of members' successes, better integration with the hospital's mission, specifically regarding graduate medical education and patient safety, and additional evaluation of the academy's impact on project completion and members' accomplishments.

  2. The XIIIth International Physiological Congress in Boston in 1929: American physiology comes of age.

    Science.gov (United States)

    Rall, Jack A

    2016-03-01

    In the 19th century, the concept of experimental physiology originated in France with Claude Bernard, evolved in Germany stimulated by the teaching of Carl Ludwig, and later spread to Britain and then to the United States. The goal was to develop a physicochemical understanding of physiological phenomena. The first International Physiological Congress occurred in 1889 in Switzerland with an emphasis on experimental demonstrations. The XIIIth Congress, the first to be held outside of Europe, took place in Boston, MA, in 1929. It was a watershed meeting and indicated that American physiology had come of age. Meticulously organized, it was the largest congress to date, with over 1,200 participants from more than 40 countries. Getting to the congress was a cultural adventure, especially for the 400 scientists and their families from over 20 European countries, who sailed for 10 days on the S.S. Minnekahda. Many of the great physiologists of the world were in attendance, including 22 scientists who were either or would become Nobel Laureates. There were hundreds of platform presentations and many experimental demonstrations. The meeting was not without controversy as a conflict, still not completely settled, arose over the discovery of ATP. After the meeting, hundreds of participants made a memorable trip to the Marine Biological Laboratory at Woods Hole, MA, which culminated in a "good old fashioned Cape Cod Clambake." Although not as spectacular as the 1929 congress, the physiological congresses have continued with goals similar to those established more than a century ago. Copyright © 2016 The American Physiological Society.

  3. Integrating Art into Places in Transition - Rose Kennedy Greenway in Boston as a Case Study

    Science.gov (United States)

    Rembeza, Magdalena

    2017-10-01

    Among the many projects realized in public spaces, some are truly unique – and these are the ones that build the identity of a place. The aim of this paper is to examine how integrating art and cultural strategies into public space can enhance and reinforce the sense of a place. Particular attention is devoted to urban spaces that we call “places in transition”, where public art improves the city’s imaginative capacity, enlivens neighbourhoods, and sparks civic exchange. Research methods include multidisciplinary literature studies and a detailed case study of the Rose Kennedy Greenway (RKG) – a contemporary urban park in Boston, USA, intended to stitch together the various neighbourhoods surrounding downtown. The Greenway is also a place in transition, to which the Conservancy introduces innovative and contemporary art through temporary exhibitions, engaging people in experiences, interactions and dialogue with art. The five-year Public Art Strategy was supported by Fund for the Arts, a public art program of the New England Foundation for the Arts. The main vision of the project is to amplify the Greenway’s unique characteristic through art that is connective, innovative, and celebratory. There are the two main types of projects within the Public Art Strategy for the RKG: short-term projects called “Platforms” and long-term projects called “Magnets”. The particular conceptual framework is being developed to guide proposals: connection, interactivity, civic dialogue, ecology, and the environment. The article examines the case and analyses the important issues related to implementing art into a public space such as re-imagining places, short-term and long-term artistic interventions, arts and cultural programming.

  4. Long-Term Visual Outcomes, Complications, and Retention of the Boston Type I Keratoprosthesis.

    Science.gov (United States)

    Aravena, Carolina; Yu, Fei; Aldave, Anthony J

    2018-01-01

    To report the long-term outcomes of the Boston type I keratoprosthesis (KPro). Data were collected regarding preoperative characteristics, surgical procedure(s) performed, and postoperative outcomes of patients who underwent KPro implantation from May 1, 2004, to May 1, 2011, and were followed for 5 years after surgery. Seventy-four KPro procedures were performed in 58 eyes (55 patients), with more than 1 KPro implanted in 10 eyes. The mean follow-up duration was 82.8 ± 20.5 months (range 57-145 months), and the most common indication for keratoprosthesis implantation was corneal transplant failure (50%). Preoperative corrected distance visual acuity (CDVA) was ≥20/200 in 5%; between 1 and 8 years after surgery, the percentage of eyes with CDVA ≥20/200 varied between 57% (4 years) and 82% (8 years). Nineteen (25.7%) KPros implanted were removed (retention failure rate 0.047/eye-year), although a KPro was retained at final follow-up in 55 eyes (94.8%). The most common postoperative complication was retroprosthetic membrane formation in 51.7% of eyes. The incidence of each postoperative complication decreased significantly over the first 10 years after surgery. The KPro provides significant visual improvement in most eyes, with more than 50% regaining and maintaining 20/200 CDVA each year through 8 years after surgery. The incidence of each postoperative complication decreases significantly over the first 10 years after surgery. Although almost one-quarter of implanted keratoprostheses were removed, over 90% of eyes reaching 5 years of follow-up retain a keratoprosthesis at final follow-up.

  5. Tear Matrix Metalloproteinases and Myeloperoxidase Levels in Patients with Boston Keratoprosthesis Type I

    Science.gov (United States)

    Robert, Marie-Claude; Arafat, Samer N; Spurr-Michaud, Sandra; Chodosh, James; Dohlman, Claes H; Gipson, Ilene K

    2016-01-01

    Purpose To investigate the tear levels of matrix metalloproteinases (MMPs), myeloperoxidase (MPO) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in eyes after Boston keratoprosthesis type I (B-KPro) implantation and to correlate these markers with established B-KPro prognostic categories. Methods Tear washes were collected from forty patients (seven with autoimmune disease, two with chemical burn and 31 patients with other non-cicatrizing diagnoses). Tear MMPs, MPO and TIMP-1 levels were quantified using multianalyte bead-based enzyme-linked immunosorbent assays. Total MMP activity was determined using a fluorimetric assay. The analytes were compared to underlying diagnosis and other clinical factors. Results MMP-8, MMP-9 and MPO levels were markedly elevated in eyes with B-KPro (80 ± 31 pg/µg, 291 ± 77 pg/µg and 244 ± 33 pg/µg, respectively). Chemical burn was associated with significantly higher tear MMP-8 (474 ± 376 pg/µg) and MMP-9 levels (1300 ± 635 pg/µg) compared to non-cicatrizing diseases (MMP-8: 41 ± 15 pg/µg, p = 0.02 and MMP-9: 196 ± 57 pg/µg, p = 0.02) and higher MMP-9 levels compared to autoimmune diseases (MMP-8: 96 ± 65 pg/µg, p = 0.21 and MMP-9: 306 ± 196 pg/µg, p = 0.04). Similar analyte levels were observed in the B-KPro eye and contralateral non B-KPro eye of patients with bilateral diseases. MMP-8, MMP-9 and total MMP activity correlated strongly with each other. Conclusions In eyes with B-KPro, tear MMP-8 and MMP-9 levels appear related to the underlying ocular surface pathology and not significantly influenced by the presence of the prosthesis. PMID:27191670

  6. The Boston Marathon Bombers: the Lethal Cocktail that Turned Troubled Youth to Terrorism

    Directory of Open Access Journals (Sweden)

    Anne Speckhard

    2013-06-01

    Full Text Available The Tsarnaev brothers came from the war-torn Chechen diaspora and found asylum in the United States. The elder brother,Tamerlan, carried actual memories of fleeing from the 1994-96 Chechen war. He also lived in Dagestan for a year at the time when the Chechen warlord Basayev was engaging in a campaign of more than thirty suicide attacks, including mass hostage takings. When Tamerlan made it to the United States, he tried to assimilate but failed to make it. The family struggled hard to make a living in the U.S.; but in the end the parents divorced and the father returned to Dagestan. Dzhokhar, the younger brother, made it into an American university but Tamerlan did not succeed in higher education, trying to pursue a boxing career instead. When his immigration status precluded a boxing career, he became disillusioned. Meanwhile his mother, concerned about his descent into smoking marijuana and drinking alcohol, arranged an Islamic tutor for him. The ingredients for the lethal cocktail of terrorism came together when Tamerlan's individual vulnerabilities made him seek online contacts via the Internet and brought him in touch with offline mentors, militants and extremists who glorified Al-Qaeda’s global jihad. Through these channels he became receptive to the terrorist ideology, found a jihadist group with global reach to align with, received technical instructions from the Inspire magazine and found enough support for executing the Boston marathon attack, pulling his younger brother along and dying in the process as he had expected.

  7. Normative data for the Brazilian population in the Boston Diagnostic Aphasia Examination: influence of schooling.

    Science.gov (United States)

    Radanovic, M; Mansur, L L; Scaff, M

    2004-11-01

    In Neurolinguistics, the use of diagnostic tests developed in other countries can create difficulties in the interpretation of results due to cultural, demographic and linguistic differences. In a country such as Brazil, with great social contrasts, schooling exerts a powerful influence on the abilities of normal individuals. The objective of the present study was to identify the influence of schooling on the performance of normal Brazilian individuals in the Boston Diagnostic Aphasia Examination (BDAE), in order to obtain reference values for the Brazilian population. We studied 107 normal subjects ranging in age from 15 to 84 years (mean +/- SD = 47.2 +/- 17.6 years), with educational level ranging from 1 to 24 years (9.9 +/- 4.8 years). Subjects were compared for scores obtained in the 28 subtests of the BDAE after being divided into groups according to age (15 to 30, N = 24, 31 to 50, N = 33 and 51 years or more, N = 50) and education (1 to 4, N = 26, 5 to 8, N = 17 and 9 years or more, N = 61). Subjects with 4 years or less of education performed poorer in Word Discrimination, Visual Confrontation Naming, Reading of Sentences and Paragraphs, and Primer-Level Dictation (P < 0.05). When breakdown by schooling was 8 years or less, subjects performed poorer in all subtests (P < 0.05), except Responsive Naming, Word Recognition and Word-Picture Matching. The elderly performed poorer (P < 0.05) in Complex Ideational Material, Visual Confrontation Naming, Comprehension of Oral Spelling, Written Confrontation Naming, and Sentences to Dictation. We present the reference values for the cut-off scores according to educational level.

  8. Normative data for the Brazilian population in the Boston Diagnostic Aphasia Examination: influence of schooling

    Directory of Open Access Journals (Sweden)

    Radanovic M.

    2004-01-01

    Full Text Available In Neurolinguistics, the use of diagnostic tests developed in other countries can create difficulties in the interpretation of results due to cultural, demographic and linguistic differences. In a country such as Brazil, with great social contrasts, schooling exerts a powerful influence on the abilities of normal individuals. The objective of the present study was to identify the influence of schooling on the performance of normal Brazilian individuals in the Boston Diagnostic Aphasia Examination (BDAE, in order to obtain reference values for the Brazilian population. We studied 107 normal subjects ranging in age from 15 to 84 years (mean ± SD = 47.2 ± 17.6 years, with educational level ranging from 1 to 24 years (9.9 ± 4.8 years. Subjects were compared for scores obtained in the 28 subtests of the BDAE after being divided into groups according to age (15 to 30, N = 24, 31 to 50, N = 33 and 51 years or more, N = 50 and education (1 to 4, N = 26, 5 to 8, N = 17 and 9 years or more, N = 61. Subjects with 4 years or less of education performed poorer in Word Discrimination, Visual Confrontation Naming, Reading of Sentences and Paragraphs, and Primer-Level Dictation (P < 0.05. When breakdown by schooling was 8 years or less, subjects performed poorer in all subtests (P < 0.05, except Responsive Naming, Word Recognition and Word-Picture Matching. The elderly performed poorer (P < 0.05 in Complex Ideational Material, Visual Confrontation Naming, Comprehension of Oral Spelling, Written Confrontation Naming, and Sentences to Dictation. We present the reference values for the cut-off scores according to educational level.

  9. Mild cognitive impairment status and mobility performance: an analysis from the Boston RISE study.

    Science.gov (United States)

    Pedersen, Mette M; Holt, Nicole E; Grande, Laura; Kurlinski, Laura A; Beauchamp, Marla K; Kiely, Dan K; Petersen, Janne; Leveille, Suzanne; Bean, Jonathan F

    2014-12-01

    The prevalence of mild cognitive impairment (MCI) and mobility limitations is high among older adults. The aim of this study was to investigate the association between MCI status and both performance-based and self-report measures of mobility in community-dwelling older adults. An analysis was conducted on baseline data from the Boston Rehabilitative Impairment Study in the Elderly study, a cohort study of 430 primary care patients aged 65 or older. Neuropsychological tests identified participants with MCI and further subclassified those with impairment in memory domains (aMCI), nonmemory domains (naMCI), and multiple domains (mdMCI). Linear regression models were used to assess the association between MCI status and mobility performance in the Habitual Gait Speed, Figure of 8 Walk, Short Physical Performance Battery, and self-reported Late Life Function and Disability Instrument's Basic Lower Extremity and Advanced Lower Extremity function scales. Participants had a mean age of 76.6 years, and 42% were characterized with MCI. Participants with MCI performed significantly worse than participants without MCI (No-MCI) on all performance and self-report measures (p performed significantly worse than No-MCI on all mobility measures (p performance on the Figure of 8 Walk and Short Physical Performance Battery, and naMCI manifested worse performance on Short Physical Performance Battery and Basic Lower Extremity. Among older community-dwelling primary care patients, performance on a broad range of mobility measures was worse among those with MCI, appearing poorest among those with nonmemory MCI. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  10. MEDIA EXPOSURE AND SYMPATHETIC NERVOUS SYSTEM REACTIVITY PREDICT PTSD SYMPTOMS AFTER THE BOSTON MARATHON BOMBINGS

    Science.gov (United States)

    Busso, Daniel S.; McLaughlin, Katie A.; Sheridan, Margaret A.

    2014-01-01

    Background Terrorist attacks have been shown to precipitate posttraumatic stress disorder (PTSD) symptomatology in children and adolescents, particularly among youths with high exposure to media coverage surrounding such events. Media exposure may be particularly likely to trigger PTSD symptoms in youths with high physiological reactivity to stress or with prior psychopathology or exposure to violence. We examined the interplay between media exposure, preattack psychopathology, autonomic nervous system (ANS) reactivity, and prior violence exposure in predicting PTSD symptom onset following the terrorist attack at the 2013 Boston Marathon. Methods A community sample of 78 adolescents (mean age = 16.7 years, 65% female) completed a survey about the bombings, including media exposure to the event and PTSD symptoms. All respondents participated in a study assessing psychopathology prior to the attack, and sympathetic and parasympathetic reactivity to a laboratory-based stressor was assessed in a subset (N = 44) of this sample. We examined the associations of media exposure, ANS reactivity, preattack psychopathology, and prior violence exposure with onset of PTSD symptoms related to the bombings. Results Media exposure, preattack psychopathology, and prior violence exposure were associated with PTSD symptoms. Moreover, media exposure interacted with sympathetic reactivity to predict PTSD symptom onset, such that adolescents with lower levels of sympathetic reactivity developed PTSD symptoms only following high exposure to media coverage of the attack. Conclusions We provide novel evidence that physiological reactivity prior to exposure to an unpredictable traumatic stressor predicts PTSD symptom onset. These findings have implications for identifying youths most vulnerable to PTSD following wide-scale trauma. PMID:24995832

  11. Sexual functioning among women with and without diabetes in the Boston Area Community Health Study.

    Science.gov (United States)

    Wallner, Lauren P; Sarma, Aruna V; Kim, Catherine

    2010-02-01

    To examine sexual dysfunction among women with and without diabetes in a community-based sample of women aged 30-79 years. We conducted a cross-sectional analysis of survey responses of female participants in the Boston Area Community Health Study, a community-based random sample, who answered questions regarding sexual functioning and diabetes status and also reported sexual activity (n = 1,291). Associations between diabetes and overall sexual function as well as domain of sexual function were examined in multivariable linear regression models. Women with type 2 diabetes (n = 75) were older, less often white, and more likely to have decreased physical activity levels, elevated body mass index, and cardiovascular disease than women without diabetes (n = 1,190). Women with type 1 diabetes (n = 26) were similar to women without diabetes except for higher depression scores and lower levels of activity. Age, marital status, and depressive symptoms were correlated with overall sexual function. After adjustment for age and race, women with and without diabetes had similar arousal, lubrication, orgasm, dyspareunia, satisfaction, and desire. After further adjustment for other factors, including age, depression, and marital status, women with type 1 diabetes had increased dyspareunia compared with women without diabetes, and women with type 2 diabetes had similar functioning to women without diabetes. Women with type 2 diabetes may have similar sexual functioning to women without diabetes, although women with type 1 diabetes may more often have dyspareunia. Factors such as depression, which are common in women with diabetes, are more strongly related to sexual dysfunction than diabetes status.

  12. Boston Violence Intervention Advocacy Program: a qualitative study of client experiences and perceived effect.

    Science.gov (United States)

    James, Thea L; Bibi, Salma; Langlois, Breanne K; Dugan, Elizabeth; Mitchell, Patricia M

    2014-07-01

    This study intended to explore clients' experiences and provide a contextual basis for understanding their perceptions of the effectiveness of the Boston Medical Center (BMC) Violence Intervention Advocacy Program (VIAP). This was an exploratory, qualitative study conducted in an urban, Level I trauma center from July 1, 2011 to February 24, 2012. Emergency department (ED) patients older than 18 years with penetrating trauma, and who were enrolled in the VIAP, were eligible. Two trained, qualitative interviewers who were not part of the VIAP obtained consent and conducted in-depth, semistructured interviews. Interviews were audiotaped, transcribed, deidentified, coded, and analyzed. Thematic content analysis consistent with grounded theory was used to identify themes related to client experiences with VIAP, life circumstances, challenges to physical and emotional healing postinjury, services provided by VIAP, and perceptions of VIAP's effectiveness. Twenty subjects were interviewed. Most were male, African American, and younger than 30 years of age, reflecting the overall program's clientele. Most subjects perceived their advocates as caring adults in their lives and cited aspects of the peer support model that helped establish trusting relationships. Major challenges to healing were fear and safety, trust, isolation as a coping mechanism, bitterness, and symptoms of posttraumatic stress disorder (PTSD). Every subject noted important services provided by VIAP advocates. Most subjects explicitly stated that they had positive experiences with the VIAP and perceived advocates' roles as a positive influence, providing client-centered advocacy, education, and support. This study provides insight into the lives of 20 BMC VIAP clients and contextualizes their unique challenges. Participants described positive, life-changing behaviors on their journey to healing through connections to caring, supportive adults. Information gained from this study will help the VIAP to

  13. The Rose Kennedy Greenway : a 30 acre green roof installation atop the Boston Big Dig

    Energy Technology Data Exchange (ETDEWEB)

    Walsh, D. [Copley Wolff Design Group, Boston, MA (United States)

    2006-07-01

    Boston's newly constructed Central Artery Tunnel (CAT) Project replaced a six-lane elevated highway with an eight-to-ten lane underground expressway directly beneath the existing road. The $14.6 billion dollar project has proven to be one of the largest, most technically and environmentally challenging infrastructure projects ever undertaken in the United States. It spans 7.8 miles of highway. The roof deck of the CAT project, commonly referred to as the Big Dig, will support a 30 parkway systems with a cross section typical of an intensive green roof. The 300 acre open urban space, formerly known as the Rose Kennedy Greenway, will include 45 parks and major public plazas. This paper reviewed the technology that supports the open space, with reference to the materials and techniques used in green roof projects, namely waterproofing, protection board, reservoir layers, planting medium, and plant material to support a layer of green over occupied spaces. The structural integrity of the tunnel decking allows for a wide variety of plant installations on the Big Dig. The installations range from open lawn areas with a 6 inch layer of planting medium. Planting beds for shrubs and perennials require up to 24 inches of planting medium. All areas over the tunnel are covered with enough structural soil to allow for root growth. All plant installations are irrigated with an underdrainage system connected to drain lines. Details of the structural soil material were presented along with a list of plants and trees species used in the landscape design. 8 figs.

  14. Association between Sleep Duration, Insomnia Symptoms and Bone Mineral Density in Older Boston Puerto Rican Adults.

    Directory of Open Access Journals (Sweden)

    Jinya Niu

    Full Text Available To examine the association between sleep patterns (sleep duration and insomnia symptoms and total and regional bone mineral density (BMD among older Boston Puerto Rican adults.We conducted a cross-sectional study including 750 Puerto Rican adults, aged 47-79 y living in Massachusetts. BMD at 3 hip sites and the lumbar spine were measured using dual-energy X-ray absorptiometry. Sleep duration (≤5 h, 6 h, 7 h, 8 h, or ≥9 h/d and insomnia symptoms (difficulty initiating sleep, difficulty maintaining sleep, early-morning awaking, and non-restorative sleep were assessed by a questionnaire. Multivariable regression was used to examine sex-specific associations between sleep duration, insomnia symptoms and BMD adjusting for standard confounders and covariates.Men who slept ≥9h/d had significantly lower femoral neck BMD, relative to those reporting 8 h/d sleep, after adjusting for age, education level, smoking, physical activity, depressive symptomatology, comorbidity and serum vitamin D concentration. This association was attenuated and lost significance after further adjustment for urinary cortisol and serum inflammation biomarkers. In contrast, the association between sleep duration and BMD was not significant in women. Further, we did not find any significant associations between insomnia symptoms and BMD in men or women.Our study does not support the hypothesis that shorter sleep duration and insomnia symptoms are associated with lower BMD levels in older adults. However, our results should be interpreted with caution. Future studies with larger sample size, objective assessment of sleep pattern, and prospective design are needed before a conclusion regarding sleep and BMD can be reached.

  15. "Subcutaneous ICD screening with the boston scientific ZOOM programmer versus a 12 lead ECG machine".

    Science.gov (United States)

    Chang, Shu C; Patton, Kristen K; Robinson, Melissa R; Poole, Jeanne E; Prutkin, Jordan M

    2018-02-24

    The subcutaneous implantable cardioverter-defibrillator (S-ICD) requires pre-implant screening to ensure appropriate sensing and reduce risk of inappropriate shocks. Screening can be performed using either an ICD programmer or a 12 lead ECG machine. It is unclear whether differences in signal filtering and digital sampling change the screening success rate. Subjects were recruited if they had a transvenous single lead ICD without pacing requirements or were candidates for a new ICD. Screening was performed using both a Boston Scientific ZOOM programmer and General Electric MAC® 5000 ECG machine. A pass was defined as having at least one lead that fit within the screening template in both supine and sitting positions. 69 subjects were included. 27 sets of ECG leads had differing screening results between the two machines (7%). Of these sets, 22 (81%) passed using the ECG machine but failed using the programmer and 5 (19%) passed using the ECG machine but failed using the programmer (p < 0.001). Four subjects (6%) passed screening using the ECG machine but failed using the programmer. No subject passed screening with the programmer but failed with the ECG machine. There can be occasional disagreement in S-ICD patient screening between an ICD programmer and ECG machine, all of whom passed with the ECG machine but failed using the programmer. On a per lead basis, the ECG machine passes more subjects. It is unknown what the inappropriate shock rate would be if an S-ICD was implanted. Clinical judgment should be used in borderline cases. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  16. The 15-item version of the Boston Naming Test as an index of English proficiency.

    Science.gov (United States)

    Erdodi, Laszlo A; Jongsma, Katherine A; Issa, Meriam

    2017-01-01

    The present study was designed to examine the potential of the Boston Naming Test - Short Form (BNT-15) to provide an objective estimate of English proficiency. A secondary goal was to examine the effect of limited English proficiency (LEP) on neuropsychological test performance. A brief battery of neuropsychological tests was administered to 79 bilingual participants (40.5% male, MAge = 26.9, MEducation = 14.2). The majority (n = 56) were English dominant (EN), and the rest were Arabic dominant (AR). The BNT-15 was further reduced to 10 items that best discriminated between EN and AR (BNT-10). Participants were divided into low, intermediate, and high English proficiency subsamples based on BNT-10 scores (≤6, 7-8, and ≥9). Performance across groups was compared on neuropsychological tests with high and low verbal mediation. The BNT-15 and BNT-10 respectively correctly identified 89 and 90% of EN and AR participants. Level of English proficiency had a large effect (partial η2 = .12-.34; Cohen's d = .67-1.59) on tests with high verbal mediation (animal fluency, sentence comprehension, word reading), but no effect on tests with low verbal mediation (auditory consonant trigrams, clock drawing, digit-symbol substitution). The BNT-15 and BNT-10 can function as indices of English proficiency and predict the deleterious effect of LEP on neuropsychological tests with high verbal mediation. Interpreting low scores on such measures as evidence of impairment in examinees with LEP would likely overestimate deficits.

  17. A Novel Nutrition Medicine Education Model: the Boston University Experience123

    Science.gov (United States)

    Lenders, Carine; Gorman, Kathy; Milch, Hannah; Decker, Ashley; Harvey, Nanette; Stanfield, Lorraine; Lim-Miller, Aimee; Salge-Blake, Joan; Judd, Laura; Levine, Sharon

    2013-01-01

    Most deaths in the United States are preventable and related to nutrition. Although physicians are expected to counsel their patients about nutrition-related health conditions, a recent survey reported minimal improvements in nutrition medicine education in US medical schools in the past decade. Starting in 2006, we have developed an educational plan using a novel student-centered model of nutrition medicine education at Boston University School of Medicine that focuses on medical student–mentored extracurricular activities to develop, evaluate, and sustain nutrition medicine education. The medical school uses a team-based approach focusing on case-based learning in the classroom, practice-based learning in the clinical setting, extracurricular activities, and a virtual curriculum to improve medical students’ knowledge, attitudes, and practice skills across their 4-y period of training. We have been using objectives from the NIH National Academy Awards guide and tools from the Association of American Medical Colleges to detect new areas of nutrition medicine taught at the medical school. Although we were only able to identify 20.5 h of teaching in the preclerkship years, we observed that most preclerkship nutrition medicine objectives were covered during the course of the 4-y teaching period, and extracurricular activities provided new opportunities for student leadership and partnership with other health professionals. These observations are very encouraging as new assessment tools are being developed. Future plans include further evaluation and dissemination of lessons learned using this model to improve public health wellness with support from academia, government, industry, and foundations. PMID:23319117

  18. Media exposure and sympathetic nervous system reactivity predict PTSD symptoms after the Boston marathon bombings.

    Science.gov (United States)

    Busso, Daniel S; McLaughlin, Katie A; Sheridan, Margaret A

    2014-07-01

    Terrorist attacks have been shown to precipitate posttraumatic stress disorder (PTSD) symptomatology in children and adolescents, particularly among youths with high exposure to media coverage surrounding such events. Media exposure may be particularly likely to trigger PTSD symptoms in youths with high physiological reactivity to stress or with prior psychopathology or exposure to violence. We examined the interplay between media exposure, preattack psychopathology, autonomic nervous system (ANS) reactivity, and prior violence exposure in predicting PTSD symptom onset following the terrorist attack at the 2013 Boston Marathon. A community sample of 78 adolescents (mean age = 16.7 years, 65% female) completed a survey about the bombings, including media exposure to the event and PTSD symptoms. All respondents participated in a study assessing psychopathology prior to the attack, and sympathetic and parasympathetic reactivity to a laboratory-based stressor was assessed in a subset (N = 44) of this sample. We examined the associations of media exposure, ANS reactivity, preattack psychopathology, and prior violence exposure with onset of PTSD symptoms related to the bombings. Media exposure, preattack psychopathology, and prior violence exposure were associated with PTSD symptoms. Moreover, media exposure interacted with sympathetic reactivity to predict PTSD symptom onset, such that adolescents with lower levels of sympathetic reactivity developed PTSD symptoms only following high exposure to media coverage of the attack. We provide novel evidence that physiological reactivity prior to exposure to an unpredictable traumatic stressor predicts PTSD symptom onset. These findings have implications for identifying youths most vulnerable to PTSD following wide-scale trauma. © 2014 Wiley Periodicals, Inc.

  19. Molecular Cloning and Functional Analysis of Three <em>FLOWERING LOCUS T (FTem> Homologous Genes from Chinese <em>Cymbidium>

    Directory of Open Access Journals (Sweden)

    Jaime A. Teixeira da Silva

    2012-09-01

    Full Text Available The <em>FLOWERING LOCUS Tem> (<em>FT> gene plays crucial roles in regulating the transition from the vegetative to reproductive phase. To understand the molecular mechanism of reproduction, three homologous <em>FT> genes were isolated and characterized from <em>Cymbidium sinenseem> “Qi Jian Bai Mo”, <em>Cymbidium goeringiiem> and <em>Cymbidium ensifoliumem> “Jin Si Ma Wei”. The three genes<em> em>contained 618-bp nucleotides with a 531-bp open reading frame (ORF of encoding 176 amino acids (AAs. Alignment of the AA sequences revealed that CsFT, CgFT and CeFT contain a conserved domain, which is characteristic of the<em> em>PEBP-RKIP superfamily, and which share high identity with FT of other plants in GenBank: 94% with OnFT<em> em>from <em>Oncidium em>Gower Ramsey, 79% with Hd3a from <em>Oryza sativaem>, and 74% with FT from <em>Arabidopsis thalianaem>. qRT-PCR analysis showed a diurnal expression pattern of <em>CsFT>, <em>CgFT> and <em>CeFT> following both long day (LD, 16-h light/8-h dark and short day (SD, 8-h light/16-h dark treatment. While the transcripts of both <em>CsFT em>and <em>CeFT em>under LD were significantly higher than under SD, those of <em>CgFT em>were> em>higher under SD. Ectopic expression of <em>CgFT> in transgenic <em>Arabidopsis> plants resulted in early flowering compared to wild-type plants and significant up-regulation of <em>APETALA1em> (<em>AP1em> expression. Our data indicates that CgFT is a putative phosphatidylethanolamine-binding protein gene in <em>Cymbidium> that may regulate the vegetative to reproductive transition in flowers, similar to its <em>Arabidopsis> ortholog.

  20. <em>α>-Glucosidase Inhibitory Constituents from <em>Acanthopanax senticosusem> Harm Leaves

    Directory of Open Access Journals (Sweden)

    Hai-Xue Kuang

    2012-05-01

    Full Text Available A new triterpene glycoside, 3-<em>O-[(α>-L-rhamnopyranosyl(1→2]-[<em>β>-D-glucuronopyranosyl-6-<em>O>-methyl ester]-olean-12-ene-28-olic acid (1 and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (5 were isolated from the leaves of <em>Acanthopanax senticosusem> Harms along with six known compounds. The structures of the new compounds were determined by means of 2D-NMR experiments and chemical methods. All the isolated compounds were evaluated for their glycosidase inhibition activities and compound 6 showed significant <em>α>-glucosidase inhibition activity.

  1. Surface epithelialization of the type I Boston keratoprosthesis front plate: immunohistochemical and high-definition optical coherence tomography characterization.

    Science.gov (United States)

    Kiang, Lee; Rosenblatt, Mark I; Sartaj, Rachel; Fernandez, Ana G Alzaga; Kiss, Szilard; Radcliffe, Nathan M; D'Amico, Donald J; Sippel, Kimberly C

    2012-08-01

    The aim of this work is to characterize a transparent tissue layer partially covering the anterior surface of the type I Boston permanent keratoprosthesis front plate in four patients. The tissue over the front plate was easily scrolled back as a single transparent layer using a sponge. In two cases, histopathologic analysis was undertaken and immunofluorescent staining with a cytokeratin 3-specific antibody was performed. The relationship of the tissue to the keratoprosthesis device was further characterized using spectral domain high-definition optical coherence tomography (HD-OCT). Histopathologic analysis revealed the tissue to be non-keratinized squamous epithelium. No goblet cells were seen, suggesting the cells were of corneal, and not conjunctival, epithelial origin. Immunofluorescent staining of all cells was positive for cytokeratin 3, a protein strongly associated with corneal epithelium. The tissue was easily discerned by HD-OCT and was of substantial thickness near the external junction between the keratoprosthesis device and the carrier corneal tissue. In three cases, visual acuity was unaffected by the presence or absence of this tissue. In one case, a prominent tissue margin temporarily obscured the visual axis and reduced visual acuity; this resolved with mechanical central debridement and has not recurred. The transparent tissue layer covering the anterior surface of the type I Boston keratoprosthesis front plate was found to represent non-keratinized squamous epithelium, most likely of corneal epithelial origin. This potentially represents a further step in bio-integration of the keratoprosthesis device. In particular, epithelial coverage of the critical junction between the device and the carrier corneal tissue might serve an important barrier function and further reduce the incidence of infection and extrusion of the type I Boston permanent keratoprosthesis.

  2. Conduct Problems Among Boston-Area Youth Following the 2013 Marathon Bombing: The Moderating Role of Prior Violent Crime Exposure.

    Science.gov (United States)

    Crum, Kathleen I; Cornacchio, Danielle; Coxe, Stefany; Greif Green, Jennifer; Comer, Jonathan S

    2017-01-01

    A large body of work documents the heavy mental health burden of youth exposure to disasters, but the majority of this research has focused on posttraumatic stress and internalizing symptoms. Less is known about associations between disaster exposure and children's conduct problems (CPs), or variables that may moderate such relationships. Given well-documented links between CPs and children's exposure to community violence, youth with greater prior community violence exposure through residence in high-crime areas may be particularly vulnerable to the impacts of disaster exposure on CPs. We surveyed Boston-area caregivers (N = 460) in the first 6 months following the 2013 Marathon bombing on their children's event-related exposures, as well as CPs. To estimate prior violent crime exposure, children's neighborhoods were assigned corresponding violent crime rates obtained from the Federal Bureau of Investigation's uniform crime reporting statistics. Almost 1 in 6 Boston-area children assessed in this convenience sample showed clinically elevated CPs in the aftermath of the Boston Marathon bombing and subsequent manhunt. Prior violent crime exposure significantly moderated the link between children's manhunt exposure (but not bombing exposure) and child CPs. Manhunt exposure was related to increased CPs among children living in areas with high and medium (but not low) levels of prior violent crime. Children living in neighborhoods characterized by violent crime may be at particularly increased risk for developing CPs after violent manmade disasters. As most postdisaster child intervention efforts focus on posttraumatic stress, efforts are needed to develop programs targeting child CPs, particularly for youth dwelling in violent neighborhoods.

  3. Serratia marcescens: Biochemical, Serological, and Epidemiological Characteristics and Antibiotic Susceptibility of Strains Isolated at Boston City Hospital

    Science.gov (United States)

    Wilfert, James N.; Barrett, Fred F.; Ewing, W. H.; Finland, Maxwell; Kass, Edward H.

    1970-01-01

    The biochemical, serological, and epidemiological characteristics of 95 strains of Serratia marcescens isolated at the Boston City Hospital were examined. Several strains were shown to be endemic, and the majority of isolates were cultured from urine or respiratory secretions. Serratia species were highly resistant to polymyxin B and the cephalosporins, and various proportions were also resistant to other antibiotics including kanamycin, but all of the isolates were sensitive to gentamicin. The appearance of resistance to kanamycin and nalidixic acid among endemic strains was demonstrated. The nosocomial nature of Serratia infections, particularly those involving the urinary tract, was confirmed. Many clinical bacteriology laboratories currently fail to identify the nonpigmented strains. PMID:4314379

  4. Expanding access to gerontological education via distance learning: the Management of Aging Services Masters Program at UMass Boston.

    Science.gov (United States)

    Nadash, Pamela; Miller, Edward Alan; Porell, Frank W; Birchander, Ellen; Glickman, Lillian; Burr, Jeffrey A

    2014-01-01

    This article describes the online Management of Aging Services Masters Program at the University of Massachusetts Boston and reports on a recent Program review. The Program has experienced rapid growth, evolving from seven matriculating students in 2003 to 108 in 2012. It has graduated 125 students and boasts a 78% completion rate. The authors describe the Program and report on faculty and student perceptions of performance. The Program demonstrates sound pedagogical practice for online education, incorporating techniques to foster community and encourage students and faculty interaction. Distance learning holds considerable promise for expanding access to gerontological education to reach future aging services professionals.

  5. Boston Keratoprosthesis Outcomes in Severe Ocular Chemical Burns in Southern China: A Retrospective Study.

    Science.gov (United States)

    Gu, Jianjun; Zhai, Jiajie; Zhou, Sheng; Chen, Jiaqi

    2016-05-01

    The objective of this study was to report clinical outcomes (functional and anatomic) of Boston keratoprosthesis (KPro) after severe chemical burns in Southern China. Nineteen patients (19 eyes) that sustained severe chemical injuries in Southern China were enrolled in this retrospective study in our hospital between May 2009 and June 2015. KPro implantation in these patients was performed by a single experienced surgeon (Jiaqi Chen). The parameters evaluated in this study included diagnosis, comorbidity, preoperative and postoperative visual acuity (VA), complications, KPro retention, histological and immunohistochemical results of retroprosthetic membrane (RPM) and mucous membrane over the optic cylinder. The mean age of the patients was 42.7 ± 11.3 years (range 29-62 years). All patients were male. Of the 19 included eyes, nine had acid burns, and 10 had alkali burns. Ten patients had previously undergone failed penetrating keratoplasty. The mean follow-up time was 41.3 ± 5.5 months (range 36-56 months). Preoperatively, the VA of the patients ranged from hand movement to light perception. Postoperatively, 17 patients (89.4%) achieved at least 20/200 once, and 7 patients (36.8%) achieved at least 20/200 and maintained this acuity until the last follow-up. The initial KPro was retained in 14 (73.6%) eyes and successfully replaced in one eye. Postoperative complications included RPM in 10 eyes, glaucoma in 6 eyes, retinal detachment in 2 eyes, corneal melting in 5 eyes, ischemic optic neuropathy in 1 eye, and overgrowth of the mucous membrane over the optical cylinder in 2 eyes. The histological and immunohistochemical results of the RPM showed granulomatous disorders and mucous membrane over the optic cylinder of conjunctival origin. KPro surgery can restore useful vision in patients suffering from severe chemical burns. However, postoperative VA declined with the development of complications, and ocular surface disorders caused by the chemical burns

  6. Microbial colonization and antibacterial resistance patterns after Boston type 1 keratoprosthesis.

    Science.gov (United States)

    Robert, Marie-Claude; Eid, Elie Patrice; Saint-Antoine, Pierre; Harissi-Dagher, Mona

    2013-08-01

    To characterize the bacterial and fungal flora colonizing the ocular surface of eyes with Boston type 1 keratoprosthesis (KPro) and to determine the prevalence of resistance to antibiotics. Culture positivity and antibiotic resistance rates in eyes with KPro are compared with those of eyes after penetrating keratoplasty (PKP) as well as control eyes. Cross-sectional, case-control study. A total of 75 eyes of 75 patients (25 KPro eyes, 25 PKP eyes, and 25 control eyes) were recruited from the Centre Hospitalier de l'Université de Montréal (Université de Montréal, Montréal, Canada) Ophthalmology Department. The inferior bulbar conjunctiva was sampled using calcium alginate swabs. Standard culture media and protocols were used to identify colonizing bacteria and fungi. Extensive antibiotic susceptibility testing was performed on every isolate. Patients completed a validated questionnaire evaluating adherence to antibiotic prophylaxis. Hospital charts were reviewed to identify risk factors for bacterial resistance. Culture positivity rates and prevalence of resistance to fourth-generation fluoroquinolones (FQ). Bacterial cultures were positive in 64% of KPro eyes, 76% of PKP eyes, and 80% of control eyes (chi-square test; P = 0.41). Fungal cultures were negative in all but 1 eye with PKP. The most common isolates were Staphylococcus epidermidis, other coagulase-negative Staphylococci, and Corynebacterium species. At least 1 bacterial isolate resistant to fourth-generation FQ was found in 44% of eyes with KPro, 24% of eyes with PKP, and 8% of control eyes (chi-square test; P = 0.01). Patient adherence to antibiotic prophylaxis did not alter microbial susceptibility to fourth-generation FQ (odds ratio, 0.83; 95% confidence interval, 0.2-4.1). Culture positivity rates and bacterial species composition were similar in KPro, PKP, and control eyes. Eyes with KPro were more likely to be colonized with FQ-resistant bacteria. Chronic prophylaxis with low-dose FQ is likely

  7. Processes influencing the transport and fate of contaminated sediments in the coastal ocean: Boston Harbor and Massachusetts Bay

    Science.gov (United States)

    Alexander, P. Soupy; Baldwin, Sandra M.; Blackwood, Dann S.; Borden, Jonathan; Casso, Michael A.; Crusius, John; Goudreau, Joanne; Kalnejais, Linda H.; Lamothe, Paul J.; Martin, William R.; Martini, Marinna A.; Rendigs, Richard R.; Sayles, Frederick L.; Signell, Richard P.; Valentine, Page C.; Warner, John C.; Bothner, Michael H.; Butman, Bradford

    2007-01-01

    Most of the major urban centers of the United States including Boston, New York, Washington, Chicago, New Orleans, Miami, Los Angeles, San Francisco, and Seattle—are on a coast (fig. 1.1). All of these cities discharge treated sewage effluent into adjacent waters. In 2000, 74 percent of the U.S. population lived within 200 kilometers (km) of the coast. Between 1980 and 2002, the population density in coastal communities increased approximately 4.5 times faster than in noncoastal areas of the U.S. (Perkins, 2004). More people generate larger volumes of wastes, increase the demands on wastewater treatment, expand the area of impervious land surfaces, and use more vehicles that contribute contaminants to street runoff. According to the National Coastal Condition Report II (U.S. Environmental Protection Agency, 2005a), on the basis of coastal habitat, water and sediment quality, benthic index, and fish tissue, the overall national coastal condition is only poor to fair and the overall coastal condition in the highly populated Northeast is poor. Scientific information helps managers to prioritize and regulate coastal-ocean uses that include recreation, commercial fishing, transportation, waste disposal, and critical habitat for marine organisms. These uses are often in conflict with each other and with environmental concerns. Developing a strategy for managing competing uses while maintaining sustainability of coastal resources requires scientific understanding of how the coastal ocean system behaves and how it responds to anthropogenic influences. This report provides a summary of a multidisciplinary research program designed to improve our understanding of the transport and fate of contaminants in Massachusetts coastal waters. Massachusetts Bay and Boston Harbor have been a focus of U.S. Geological Survey (USGS) research because they provide a diverse geographic setting for developing a scientific understanding of the geology, geochemistry, and oceanography of

  8. Resposta espectral de solos em razão do ângulo de visada, da umidade e da rugosidade superficial

    Directory of Open Access Journals (Sweden)

    ACCIOLY LUCIANO JOSÉ DE OLIVEIRA

    2000-01-01

    Full Text Available Este trabalho teve por objetivo avaliar as variações do fator de refletância bidirecional (FRB de três séries de solo (McAllister, Stronghold e Epitaph da microbacia experimental de Walnut Gulch (Arizona, EUA em razão do ângulo de visada, da rugosidade superficial e do teor de umidade. Foram consideradas as faixas espectrais do visível e do infravermelho próximo e médio presentes no sensor TM, e os resultados foram expressos em termos de FRB em relação à resposta no Nadir (FRB relativo. O anisotropismo variou de solo para solo e foi maior nas menores faixas espectrais, nos ângulos de visada maiores localizados na direção do retroespalhamento, nos ângulos solar-zenitais maiores, e na condição de solo seco. No solo Epitaph (único solo submetido ao estudo de rugosidade o anisotropismo foi também maior na superfície mais rugosa. Entretanto, uma melhor diferenciação entre as superfícies lisa e rugosa do solo Epitaph foi obtida na direção do espalhamento da energia refletida. Diferenças na escala e nos métodos de obtenção dos dados são apontadas como causas do realce do comportamento anisotrópico dos dados obtidos em condições de laboratório, em comparação com os dados de campo.

  9. The Boston Puerto Rican Health Study, a longitudinal cohort study on health disparities in Puerto Rican adults: challenges and opportunities

    Directory of Open Access Journals (Sweden)

    Collado Bridgette M

    2010-03-01

    Full Text Available Abstract Background The Boston Puerto Rican Health Study is an ongoing longitudinal cohort study designed to examine the role of psychosocial stress on presence and development of allostatic load and health outcomes in Puerto Ricans, and potential modification by nutritional status, genetic variation, and social support. Methods Self-identified Puerto Ricans, aged 45-75 years and residing in the Boston, MA metro area, were recruited through door-to-door enumeration and community approaches. Participants completed a comprehensive set of questionnaires and tests. Blood, urine and salivary samples were extracted for biomarker and genetic analysis. Measurements are repeated at a two-year follow-up. Results A total of 1500 eligible participants completed baseline measurements, with nearly 80% two-year follow-up retention. The majority of the cohort is female (70%, and many have less than 8th grade education (48%, and fall below the poverty level (59%. Baseline prevalence of health conditions is high for this age range: considerable physical (26% and cognitive (7% impairment, obesity (57%, type 2 diabetes (40%, hypertension (69%, arthritis (50% and depressive symptomatology (60%. Conclusions The enrollment of minority groups presents unique challenges. This report highlights approaches to working with difficult to reach populations, and describes some of the health issues and needs of Puerto Rican older adults. These results may inform future studies and interventions aiming to improve the health of this and similar communities.

  10. Are first-generation adolescents less likely to be overweight? Results from a survey of Boston youth.

    Science.gov (United States)

    Sonneville, Kendrin R; Duncan, Dustin T; Johnson, Renee M; Almeida, Joanna

    2015-04-01

    The effect of years of residence in the US on the weight of adolescents is unclear. We examined the association between generation (i.e. 1st, 1.5, 2nd, and 3rd) and weight indicators among Boston adolescents. Data are from a sample of 1,420 9-12th grade public school students in Boston, Massachusetts. We used self-reported information to calculate generation and weight characteristics (i.e., body mass index (BMI), BMI z-score, overweight status), and ran multivariate analyses to estimate the association between generation and weight characteristics, adjusting for race/ethnicity, gender, age and school. In pooled multivariate models, 1.5 generation, second generation, and third generation youth had significantly higher mean BMI scores and mean BMI z-scores than first generation youth. Second (RR 1.87, 95% CI 1.13-3.12) and third generation youth (RR 2.06, 95% CI 1.21-3.50) were also significantly more likely to be overweight than first generation youth. In multivariate models stratified by sex, this pattern persisted for females only. There is a positive, linear trend in BMI by generation that differs by gender. Mechanisms underlying this association should be addressed.

  11. Measurements and modeling of greenhouse gases and the planetary boundary layer for the Boston metro area and the Northeastern Megalopolis

    Science.gov (United States)

    DeCola, Philip; Jones, Taylor; Wofsy, Steven; McKain, Kathryn; Chen, Jia; Bererra, Yanina; Gottlieb, Elaine; Nehrkorn, Thomas; Hegarty, Jennifer; Eluszkiewicz, Janusz; Henderson, John; Mountain, Marikate; Hutyra, Lucy; Callahan, William

    2014-05-01

    The accuracy of greenhouse gas (GHG) emission and air quality simulations reflects the fidelity of the atmospheric transport model employed that in turn is highly dependent on the accuracy of the meteorological input data. We begin by describing a multi-scale measurement network and model-data analysis framework for the Boston Metro region, with extension to the mid-Atlantic urban corridor. Observations include a network of automated concentrations of CO2 and CH4 inside and outside the urban domain, near the surface, on towers and tall buildings, total column measurements using the sun as a source, aerosol LiDAR data defining atmospheric structure, and meteorological data. The model-data analysis framework includes a Lagrangian particle dispersion model (LPDM), the Stochastic Time-Inverted Lagrangian Transport (STILT), driven by meteorological fields from the North American Regional Reanalysis (NARR) and Weather Research and Forecasting (WRF) model, and an inversion framework. We show examples of data and discuss the observational network's sampling design and a plan for extension to the NE urban corridor of the US. These urban studies are demonstrating the feasibility and value of incorporating advanced instrumentation such as the Mini Micro Pulse LiDAR to evaluate and improve the fidelity of the WRF simulations of atmospheric transport and structure in the planetary boundary layer. We also present examples of inverse analyses assessing anthropogenic emission rates for CH4 and CO2 in the urban region of metro Boston and along the urban-rural gradient.

  12. Annual emissions and air-quality impacts of an urban area district-heating system: Boston case study

    Energy Technology Data Exchange (ETDEWEB)

    Bernow, S.S.; McAnulty, D.R.; Buchsbaum, S.; Levine, E.

    1980-02-01

    A district-heating system, based on thermal energy from power plants retrofitted to operate in the cogeneration mode, is expected to improve local air quality. This possibility has been examined by comparing the emissions of five major atmospheric pollutants, i.e., particulates, sulfur oxides, carbon monoxide, hydrocarbons, and nitrogen oxides, from the existing heating and electric system in the City of Boston with those from a proposed district heating system. Detailed, spatial distribution of existing heating load and fuel mix is developed to specify emissions associated with existing heating systems. Actual electric-power-plant parameters and generation for the base year are specified. Additional plant fuel consumption and emissions resulting from cogeneration operation have been estimated. Six alternative fuel-emissions-control scenarios are considered. The average annual ground-level concentrations of sulfur oxides are calculated using a modified form of the EPA's Climatological Dispersion Model. This report describes the methodology, the results and their implications, and the areas for extended investigation. The initial results confirm expectations. Average sulfur oxides concentrations at various points within and near the city drop by up to 85% in the existing fuels scenarios and by 95% in scenarios in which different fuels and more-stringent emissions controls at the plants are used. These reductions are relative to concentrations caused by fuel combustion for heating and large commercial and industrial process uses within the city and Boston Edison Co. electric generation.

  13. Caregiver-reports of Internet Exposure and Posttraumatic Stress Among Boston-Area Youth Following the 2013 Marathon Bombing.

    Science.gov (United States)

    Comer, Jonathan S; DeSerisy, Mariah; Green, Jennifer Greif

    2016-01-01

    Although practitioners and researchers have considered children's television-based terrorism exposure, Internet-based exposure has not been sufficiently examined. We examined the scope and correlates of children's Internet-based exposure following the Boston Marathon bombing among Boston-area youth (N=460; 4-19 years), and the potential moderating role of age. Further exploratory analyses examined patterns of caregiver attempts to regulate child Internet exposure. Caregivers reported on child Internet-based and direct exposure to traumatic bombing-related events, and youth posttraumatic stress (PTS). Online youth consumed on average over two daily hours of Internet coverage, and roughly one-third consumed over three daily hours of coverage. Internet exposure was particularly high among children over 12. Greater Internet-based exposure was associated with PTS, and 12-15 year olds were particularly vulnerable. Further exploratory analyses found that although most caregivers reported believing media exposure can cause children further trauma, a considerable proportion of caregivers made no attempt to restrict or regulate their child's Internet-based exposure. These findings help practitioners clarify forms of indirect exposure that can place youth at risk following terrorism. Future work is needed to examine the important roles caregivers play as media regulators and as promoters of child coping and media literacy following terrorism.

  14. Caregiver distress, shared traumatic exposure, and child adjustment among area youth following the 2013 Boston Marathon bombing.

    Science.gov (United States)

    Kerns, Caroline E; Elkins, R Meredith; Carpenter, Aubrey L; Chou, Tommy; Green, Jennifer Greif; Comer, Jonathan S

    2014-01-01

    Disasters are associated with myriad negative outcomes in youth, including posttraumatic stress disorder and related psychopathology. Prior work suggests links between caregiver distress and child mental health outcomes following community traumas, but the extent to which caregiver distress is directly linked to post-disaster child functioning, or whether such associations may simply be due to shared traumatic exposure, remains unclear. The current study examined relationships among caregiver distress, caregiver-child shared traumatic exposure, and child outcomes in Boston-area families (N=460) during the six months following the 2013 Boston Marathon bombing. Parents completed surveys about their and their child׳s potentially traumatic experiences during the bombing and subsequent manhunt. Post-attack caregiver distress and child psychological functioning were also assessed. After accounting for caregiver-child shared traumatic exposure, significant associations were retained between caregiver distress and child functioning across several domains. Furthermore, after accounting for caregiver traumatic exposure, caregiver distress moderated relationships between child traumatic exposure and child posttraumatic stress and conduct problems, such that associations between child traumatic exposure and child posttraumatic stress and conduct problems were particularly strong among children of highly distressed caregivers. The cross-sectional design did not permit evaluations across time, and population-based methods were not applied. Findings clarify links between caregiver distress and child psychopathology in the aftermath of disaster and can inform optimal allocation of clinical resources targeting disaster-affected youth and their families. Copyright © 2014 Elsevier B.V. All rights reserved.

  15. Caregiver-reports of Internet Exposure and Posttraumatic Stress Among Boston-Area Youth Following the 2013 Marathon Bombing

    Science.gov (United States)

    Comer, Jonathan S.; DeSerisy, Mariah; Green, Jennifer Greif

    2017-01-01

    Although practitioners and researchers have considered children’s television-based terrorism exposure, Internet-based exposure has not been sufficiently examined. We examined the scope and correlates of children’s Internet-based exposure following the Boston Marathon bombing among Boston-area youth (N=460; 4–19 years), and the potential moderating role of age. Further exploratory analyses examined patterns of caregiver attempts to regulate child Internet exposure. Caregivers reported on child Internet-based and direct exposure to traumatic bombing-related events, and youth posttraumatic stress (PTS). Online youth consumed on average over two daily hours of Internet coverage, and roughly one-third consumed over three daily hours of coverage. Internet exposure was particularly high among children over 12. Greater Internet-based exposure was associated with PTS, and 12–15 year olds were particularly vulnerable. Further exploratory analyses found that although most caregivers reported believing media exposure can cause children further trauma, a considerable proportion of caregivers made no attempt to restrict or regulate their child’s Internet-based exposure. These findings help practitioners clarify forms of indirect exposure that can place youth at risk following terrorism. Future work is needed to examine the important roles caregivers play as media regulators and as promoters of child coping and media literacy following terrorism. PMID:28770253

  16. “We Make the Path by Walking It”: Building an Academic Community Partnership With Boston Chinatown

    Science.gov (United States)

    Rubin, Carolyn Leung; Allukian, Nathan; Wang, Xingyue; Ghosh, Sujata; Huang, Chien-Chi; Wang, Jacy; Brugge, Doug; Wong, John B.; Mark, Shirley; Dong, Sherry; Koch-Weser, Susan; Parsons, Susan K.; Leslie, Laurel K.; Freund, Karen M.

    2015-01-01

    Background The potential for academic community partnerships are challenged in places where there is a history of conflict and mistrust. Addressing Disparities in Asian Populations through Translational Research (ADAPT) represents an academic community partnership between researchers and clinicians from Tufts Medical Center and Tufts University and community partners from Boston Chinatown. Based in principles of community-based participatory research and partnership research, this partnership is seeking to build a trusting relationship between Tufts and Boston Chinatown. Objectives This case study aims to provides a narrative story of the development and formation of ADAPT as well as discuss challenges to its future viability. Methods Using case study research tools, this study draws upon a variety of data sources including interviews, program evaluation data and documents. Results Several contextual factors laid the foundation for ADAPT. Weaving these factors together helped to create synergy and led to ADAPT’s formation. In its first year, ADAPT has conducted formative research, piloted an educational program for community partners and held stakeholder forums to build a broad base of support. Conclusions ADAPT recognizes that long term sustainability requires bringing multiple stakeholders to the table even before a funding opportunity is released and attempting to build a diversified funding base. PMID:25435562

  17. The 'Twinkie Defense': the relationship between carbonated non-diet soft drinks and violence perpetration among Boston high school students.

    Science.gov (United States)

    Solnick, Sara J; Hemenway, David

    2012-08-01

    To investigate the association of carbonated non-diet soft drink consumption and violence perpetration in a sample of Boston adolescents. In a survey of Boston public high schools, respondents were asked how often they drank non-diet soft drinks and whether they had carried a weapon or engaged in physical violence with a peer. Regression analysis was used to determine the role of soft drink consumption in these behaviours. Adolescents who drank more than five cans of soft drinks per week (nearly 30% of the sample) were significantly more likely to have carried a weapon and to have been violent with peers, family members and dates (pactions, even after controlling for gender, age, race, body mass index, typical sleep patterns, tobacco use, alcohol use and having family dinners. There was a significant and strong association between soft drinks and violence. There may be a direct cause-and-effect relationship, perhaps due to the sugar or caffeine content of soft drinks, or there may be other factors, unaccounted for in our analyses, that cause both high soft drink consumption and aggression.

  18. Neonatal Phosphate Nutrition Alters <em>in em>Vivo> and <em>in em>Vitro> Satellite Cell Activity in Pigs

    Directory of Open Access Journals (Sweden)

    Chad H. Stahl

    2012-05-01

    Full Text Available Satellite cell activity is necessary for postnatal skeletal muscle growth. Severe phosphate (PO4 deficiency can alter satellite cell activity, however the role of neonatal PO4 nutrition on satellite cell biology remains obscure. Twenty-one piglets (1 day of age, 1.8 ± 0.2 kg BW were pair-fed liquid diets that were either PO4 adequate (0.9% total P, supra-adequate (1.2% total P in PO4 requirement or deficient (0.7% total P in PO4 content for 12 days. Body weight was recorded daily and blood samples collected every 6 days. At day 12, pigs were orally dosed with BrdU and 12 h later, satellite cells were isolated. Satellite cells were also cultured <em>in vitroem> for 7 days to determine if PO4 nutrition alters their ability to proceed through their myogenic lineage. Dietary PO4 deficiency resulted in reduced (<em>P> < 0.05 sera PO4 and parathyroid hormone (PTH concentrations, while supra-adequate dietary PO4 improved (<em>P> < 0.05 feed conversion efficiency as compared to the PO4 adequate group. <em>In vivoem> satellite cell proliferation was reduced (<em>P> < 0.05 among the PO4 deficient pigs, and these cells had altered <em>in vitroem> expression of markers of myogenic progression. Further work to better understand early nutritional programming of satellite cells and the potential benefits of emphasizing early PO4 nutrition for future lean growth potential is warranted.

  19. Desempenho das Exportações da Indústria Intensiva em P&D: comparação entre o Brasil e países selecionados no período de 1994-2005

    Directory of Open Access Journals (Sweden)

    Samantha Ferreira e Cunha

    2008-01-01

    Full Text Available O artigo trata da inserção exportadora de produtos de alta intensidade tecnológica do Brasil entre 1994 e 2005, comparando tal inserção externa com a experiência de países desenvolvidos (EUA e Japão e países em desenvolvimento (Coréia do Sul e México. Para tanto, o artigo utiliza a metodologia desenvolvida por Pavitt (1984 para classificar as exportações segundo as capacidades tecnológicas dos setores e respectivos encadeamentos intra e interindustrial e desempenho exportador. Os resultados encontrados apontam que os países em desenvolvimento apresentaram um crescimento das exportações da “indústria intensiva em P&D”, todavia, seu market-share ainda é muito baixo vis-à-vis a experiência das economias desenvolvidas.The article investigates the export insertion of Brazilian high technological intensity products between 1994 to 2005 by comparing such international insertion with the experience of both developed (USA and Japan and developing countries (South Korea and Mexico. The methodology developed by Pavitt (1984 is applied for classifying exports by sectors according to their technological capacity, concatenations intra and interindustry and export performance. The results show that high-tech exports increased in developing countries, but their market-share is very low when compared to the experience of developed economies.

  20. Constituents from <em>Vigna em>vexillata> and Their Anti-Inflammatory Activity

    Directory of Open Access Journals (Sweden)

    Guo-Feng Chen

    2012-08-01

    Full Text Available The seeds of <em>Vigna em>genus are important food resources and there have already been many reports regarding their bioactivities. In our preliminary bioassay, the chloroform layer of methanol extracts of<em> V. vexillata em>demonstrated significant anti-inflammatory bioactivity. Therefore, the present research is aimed to purify and identify the anti-inflammatory principles of <em>V. vexillataem>. One new sterol (1 and two new isoflavones (2,3 were reported from the natural sources for the first time and their chemical structures were determined by the spectroscopic and mass spectrometric analyses. In addition, 37 known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. Among the isolates, daidzein (23, abscisic acid (25, and quercetin (40 displayed the most significant inhibition of superoxide anion generation and elastase release.

  1. Spatial and temporal variations in atmospheric temperature and humidity gradients controlled by local urban land use intensity in Boston, MA

    Science.gov (United States)

    Wang, J.; Hutyra, L.; Li, D.; Friedl, M. A.

    2016-12-01

    Cities are home to the majority of humanity. Thus, understanding the mechanisms that control urban climates has substantial societal importance to a variety of sectors, including public health and energy management. While it is widely known that the surface climate of cities is modified by urban land use, relatively few studies have examined how spatial variability in urban land use intensity controls spatio-temporal variation in urban microclimates. We used data from an urban sensor network (n=25) and medium resolution remote sensing to explore the nature and magnitude of urban air temperature (Ta) and vapor pressure deficit (VPD) dependence on local land use and land cover on both diurnal and seasonal time scales in the Boston metropolitan area. We observed positive correlations between the amount of local impervious surface area (ISA) and Ta as well as strong positive correlations between local ISA and VPD. Dependence on local urbanization intensity peaked at night during the growing season, when urban Ta and VPD increased by up to 0.03 C and 0.008 kPa, respectively, for every 1% increase in ISA. In the daytime during the growing season, corresponding maximum gradients were 0.015 C and 0.006 kPa per for every 1% increase in ISA. Air temperatures and VPDs are coupled to each other, and their relationship exhibits significant diurnal hysteresis during the growing season with changes in VPD gradients generally preceding changes in Ta gradients. By removing the effect of changes in temperature on VPD, we show that 79% of the urban-rural difference in VPD was explained by differences in near surface atmospheric water content, which we attribute to lower rates of evapotranspiration arising from higher ISA, lower canopy cover, and lower leaf area in Boston relative to nearby rural areas. Combining medium resolution remote sensing data and ground measurements, we estimate spatially-explicit maps of net Ta and VPD enhancement resulting from Boston's spatially

  2. Pathways to Banking: Improving Access for Students from Non-Privileged Backgrounds. Research by The Boston Consulting Group for the Sutton Trust

    Science.gov (United States)

    Kelly, Gerard

    2014-01-01

    The financial services sector is a vital and vibrant part of a national economy but it recruits from a small and relatively privileged segment of society. This report, which summarises research from the Boston Consulting Group (BCG), shows for the first time the extent of the challenge. The Sutton Trust's "Pathways to Banking" programme…

  3. INDOOR AND OUTDOOR SOURCE CONTRIBUTIONS TO PERSONAL PM2.5 FOR A PANEL OF INDIVIDUALS WITH CARDIOVASCULAR DISEASE OR COPD LIVING IN BOSTON, MA

    Science.gov (United States)

    Repeated personal, home indoor, home outdoor, and ambient particulate and gaseous pollutant levels were characterized for individuals with cardiovascular disease or COPD and their partners living in the Boston area. Health status was determined by self-reported history of myoc...

  4. Lessons From the Boston Marathon Bombing: An Orthopaedic Perspective on Preparing for High-Volume Trauma in an Urban Academic Center.

    Science.gov (United States)

    Tobert, Daniel; von Keudell, Arvind; Rodriguez, Edward K

    2015-10-01

    The 2013 Boston Marathon bombing resulted in a mass casualty event that tested the limits of Boston-area trauma centers. The explosions, 12 seconds apart, led to the rapid influx of 124 patients with primarily lower extremity injuries in 5 different adult level 1 trauma centers. This study aimed to examine the existing hospital systems in place for disaster scenarios at the time of the event and identify areas for improvement. Preparation before the Boston Marathon bombing included coordinating the delivery of patients to area facilities and creating a framework for response at an institutional level. These simulations, coupled with the fact that the explosions occurred at a nexus of medical facilities, helped provide impactful care preventing any fatalities in patients who arrived at a Boston hospital that day. The experience at our institution led to the implementation of a more robust communication infrastructure and reinforced the value of preparatory drills. Within the Orthopaedic Surgery Department, we developed a more robust organizational hierarchy for mass casualty events and implemented a multitrauma follow-up clinic. We believe that it is the responsibility of every hospital to have systems in place to handle the rapid arrival of patients with multiple-trauma, and we hope that others can learn from our experience.

  5. The effects on smokers of Boston's smoke-free bar ordinance: a longitudinal analysis of changes in compliance, patronage, policy support, and smoking at home.

    Science.gov (United States)

    Biener, Lois; Garrett, Catherine A; Skeer, Margie; Siegel, Michael; Connolly, Gregory

    2007-01-01

    We prospectively examined effects of the implementation of a smoking ban in bars on Boston, Massachusetts, smokers. A representative sample of Massachusetts smokers was interviewed before and after the smoking ban was implemented in Boston. Participants were adult smokers living in Boston (n = 83) and in 203 other Massachusetts cities and towns that did not adopt smoking bans in bars prior to July 2004 (n = 903). The outcome measures were changes in reports of smoking in bars, frequency of bar patronage, support for smoke-free bars, smoking at home, and exposure to secondhand smoke at home based on town of residence. Compared to changes over the same time period among smokers in towns where smoking in bars was permitted, smokers in Boston were significantly less likely to observe smoking and less likely to decrease their bar patronage after the smoking ban was implemented. Changes in support for smoke-free bars, smoking patterns at home, and exposure to secondhand smoke at home did not differ between the groups. Expectations about noncompliance, declines in patronage, and displacement of smoking to the home as a consequence of extending smoking restrictions to bars are not supported by the data.

  6. Differences in the Professional Satisfaction of General Internists in Academically Affiliated Practices in the Greater-Boston Area

    Science.gov (United States)

    Haas, Jennifer S; Cleary, Paul D; Puopolo, Ann Louise; Burstin, Helen R; Cook, E Francis; Brennan, Troyen A

    1998-01-01

    Managed care has created more professional constraints for general internists. We surveyed 198 general internists at 12 academically affiliated practices in the greater-Boston area to examine professional satisfaction. Overall, these physicians were moderately satisfied (mean of 59.1 on a 100-point scale). Before adjustment, women had lower overall satisfaction than men, as well as poorer satisfaction with the domains of career concerns and patient access. Gender had no independent effect on satisfaction after adjustment for age, income, percentage of time providing direct patient care, work status, and site. Younger physicians also had lower overall satisfaction, and these differences remained after adjustment. Improvements in professional satisfaction may be required to ensure the continued recruitment of young physicians, particularly women, into general internal medicine. PMID:9502374

  7. Oral buccal mucous membrane allograft with a corneal lamellar graft for the repair of Boston type 1 keratoprosthesis stromal melts.

    Science.gov (United States)

    Ziai, Setareh; Rootman, David S; Slomovic, Allan R; Chan, Clara C

    2013-11-01

    To describe a surgical technique to repair Boston type 1 keratoprosthesis (KPro)-related corneal melts. Technique description and review of 3 representative cases. After harvesting the buccal mucosa from the patient's inner lower lip, the exposed area of the KPro back plate is prepared for repair by adequate exposure and removal of necrotic tissue. The area is then covered with a lamellar patch of cornea secured in place with interrupted 10-0 nylon sutures, followed by a thin layer of buccal mucosa secured in place with interrupted 8-0 vicryl sutures. This technique provides surgeons with a method to repair KPro-related corneal melts when there is a conjunctival deficiency.

  8. Language barriers among patients in Boston emergency departments: use of medical interpreters after passage of interpreter legislation.

    Science.gov (United States)

    Ginde, Adit A; Clark, Sunday; Camargo, Carlos A

    2009-12-01

    Since 2001, Massachusetts state law dictates that emergency department (ED) patients with limited English proficiency have the right to a professional interpreter. One year later, for two 24-h periods, we interviewed adult patients presenting to four Boston EDs. We assessed language barriers and compared this need with the observed use and type of interpreter during the ED visit. We interviewed 530 patients (70% of eligible) and estimated that an interpreter was needed for 60 (11%; 95% confidence interval, 7-12%) patients. The primary interpreter for these clinical encounters was a physician (30%), friend or family member age >or=18 years (22%), hospital interpreter services (15%), younger family member (11%), or other hospital staff (17%). We found that 11% of ED patients had significant language barriers, but use of professional medical interpreters remained low. One year after passage of legislation mandating access, use of professional medical interpreters remained inadequate.

  9. An Intractable Case of Prototheca Keratitis and Chronic Endophthalmitis in Stevens-Johnson Syndrome With Boston Type 1 Keratoprosthesis.

    Science.gov (United States)

    Ng, Jacqueline; Minckler, Don; Walsh, Thomas J; Farid, Marjan

    2016-09-01

    To report a case of recalcitrant Prototheca spp. keratitis and endophthalmitis in a patient with Stevens-Johnson syndrome (SJS) and Boston type 1 keratoprosthesis (B1 KPro). Case report. A 67-year-old female with a history of SJS with chronic severe ocular surface disease in her monocular left eye underwent placement of a B1 KPro. Her course was subsequently complicated by persistent Prototheca spp. keratitis and endophthalmitis requiring ongoing treatment with triazole and polyene antifungal agents and multiple surgical revisions of her keratoprosthesis. Protothecosis is an algal infection that is rarely pathologic in humans, but when present can be difficult to manage. We present the second known case of persistent chronic Prototheca spp. keratitis and endophthalmitis in a patient with long-standing SJS and B1 KPro.

  10. Long-Term Outcomes of the Boston Type I Keratoprosthesis in the Management of Corneal Limbal Stem Cell Deficiency.

    Science.gov (United States)

    Aravena, Carolina; Bozkurt, Tahir Kansu; Yu, Fei; Aldave, Anthony J

    2016-09-01

    To report the long-term outcomes of the Boston type I keratoprosthesis (KPro) in the management of limbal stem cell deficiency (LSCD). Retrospective review of KPro procedures performed by a single surgeon from May 1, 2004, to January 1, 2015. One hundred seventy-three KPro procedures were performed in 149 eyes, including 68 in 54 eyes with LSCD. Glaucoma (48% vs. 82%, P keratoprosthesis implantation results in a significant improvement in CDVA in the majority of eyes with LSCD through 5 years after surgery, with better visual outcomes than eyes without LSCD. Although several postoperative complications are more common in LSCD, sight-threatening complications such as endophthalmitis and retinal detachment are not. Additionally, there is no difference in the retention failure rate in eyes with and without LSCD, although a larger number of procedures with longer follow-up will be needed to determine retention outcomes more than 5 years after surgery.

  11. The Usage of a Conjunctival Flap to Improve Retention of Boston Type 1 Keratoprosthesis in Severe Ocular Surface Disease.

    Science.gov (United States)

    Eghrari, Allen O; Ahmad, Sumayya; Ramulu, Pradeep; Iliff, Nicholas T; Akpek, Esen Karamursel

    2016-10-01

    The Boston keratoprostheses type 1 devices (KPro) are utilized in cases unfavorable to penetrating keratoplasty. The prognosis remains guarded in cases of ocular surface disease due to risk of tissue necrosis. We describe a novel surgical approach using a conjunctival flap with a delayed opening to improve retention. In three patients with advanced cicatrizing conjunctivitis, a Type 1 keratoprosthesis was stabilized using a full tarsal conjunctival flap. Three months postoperatively, an opening was created in the flap overlying the optical portion of the device. All patients had no device related complications over a mean follow-up period of 17.7 months (range 15-21 months) and vision remained excellent at better than 20/200 for all patients. Utilization of a tarsal flap either primarily as part of a two stage modified technique or secondarily in cases of tissue necrosis and impending device extrusion might maximize retention of the type 1 KPro.

  12. SP2 Deployment at Boston College—Aerodyne-Led Coated Black Carbon Study (BC4) Final Campaign Summary

    Energy Technology Data Exchange (ETDEWEB)

    Onasch, T. B. [Aerodyne Research, Inc., Billerica, MA (United States); Sedlacek, A. J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-03-01

    The main objective of the Boston College-Aerodyne led laboratory study (BC4) was to measure the optical properties of black carbon (BC) particles from a diffusion flame directly and after being coated with secondary organic and inorganic material and to achieve optical closure with model predictions. The measurements of single particle BC mass and population mixing states provided by a single particle soot photometer (SP2) was central to achieving the laboratory-based study’s objective. Specifically, the DOE ARM SP2 instrument participated in the BC4 project to address the following scientific questions: 1. What is the mass-specific absorption coefficient as a function of secondary organic and inorganic material coatings? 2. What is the spread in the population mixing states within our carefully generated laboratory particles? 3. How does the SP2 instrument respond to well-characterized, internally mixed BC-containing particles?

  13. Evaluating the Impact of the Healthy Beverage Executive Order for City Agencies in Boston, Massachusetts, 2011–2013

    Science.gov (United States)

    Kenney, Erica L.; McHugh, Anne; Conley, Lisa; Mozaffarian, Rebecca S.; Reiner, Jennifer F.; Gortmaker, Steven L.

    2015-01-01

    Introduction Intake of sugar-sweetened beverages (SSBs) is associated with negative health effects. Access to healthy beverages may be promoted by policies such as the Healthy Beverage Executive Order (HBEO) established by former Boston mayor Thomas M. Menino, which directed city departments to eliminate the sale of SSBs on city property. Implementation consisted of “traffic-light signage” and educational materials at point of purchase. This study evaluates the impact of the HBEO on changes in beverage availability. Methods Researchers collected data on price, brand, and size of beverages for sale in spring 2011 (899 beverage slots) and for sale in spring 2013, two years after HBEO implementation (836 beverage slots) at access points (n = 31) at city agency locations in Boston. Nutrient data, including calories and sugar content, from manufacturer websites were used to determine HBEO beverage traffic-light classification category. We used paired t tests to examine change in average calories and sugar content of beverages and the proportion of beverages by traffic-light classification at access points before and after HBEO implementation. Results Average beverage sugar grams and calories at access points decreased (sugar, −13.1 g; calories, −48.6 kcal; p<.001) following the implementation of the HBEO. The average proportion of high-sugar (“red”) beverages available per access point declined (−27.8%, p<.001). Beverage prices did not change over time. City agencies were significantly more likely to sell only low-sugar beverages after the HBEO was implemented (OR = 4.88; 95% CI, 1.49–16.0). Discussion Policies such as the HBEO can promote community-wide changes that make healthier beverage options more accessible on city-owned properties. PMID:26355828

  14. Visual Outcomes and Complications of Type I Boston Keratoprosthesis in Children: A Retrospective Multicenter Study and Literature Review.

    Science.gov (United States)

    Fung, Simon S M; Jabbour, Samir; Harissi-Dagher, Mona; Tan, Reginald R G; Hamel, Patrick; Baig, Kashif; Ali, Asim

    2017-08-11

    To report outcomes and complications of Boston type 1 keratoprosthesis (KPro) implantation in children. Retrospective, multicenter case series. All children 16 years of age or younger who underwent KPro surgery at 3 ophthalmology centers in Canada between January 2010 and November 2014. Records of patients having undergone KPro implantation were reviewed. Data on preoperative characteristics, surgical procedure(s) performed, and postoperative outcomes were collected and analyzed. Intraoperative and postoperative complications, device retention, and best-corrected visual acuity (BCVA). The KPro was implanted in 11 eyes of 11 patients 0.9 to 15.5 years of age, with 6 being primary corneal procedures. Best-corrected visual acuity recorded before surgery ranged from 20/125 to light perception (LP), and vision in 2 eyes was fix and follow. All patients had been diagnosed with glaucoma and 6 eyes had glaucoma drainage devices (GDDs) inserted before KPro implantation. At last follow-up (mean, 41.8 months; range, 6.5-85.0 months), 2 eyes retained BCVA of 20/400 or better, whereas 5 eyes lost LP. Postoperative complications included retroprosthetic membrane (9 eyes), corneal melt (5 eyes), infectious keratitis (3 eyes), endophthalmitis (3 eyes), GDD erosion (2 eyes), and retinal detachment (5 eyes). The initial KPro was retained in 4 eyes (36.4%). Boston type 1 keratoprosthesis implantation in children is associated with a substantially higher rate of complications, higher chance of device failure, and worse visual outcomes than observed in adults. In view of these results, the authors do not recommend the use of the KPro in the pediatric population. Copyright © 2017 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  15. The effects of biogeography on ant diversity and activity on the Boston Harbor Islands, Massachusetts, U.S.A.

    Directory of Open Access Journals (Sweden)

    Adam T Clark

    Full Text Available Many studies have examined how island biogeography affects diversity on the scale of island systems. In this study, we address how diversity varies over very short periods of time on individual islands. To do this, we compile an inventory of the ants living in the Boston Harbor Islands National Recreation Area, Boston, Massachusetts, USA using data from a five-year All Taxa Biodiversity Inventory of the region's arthropods. Consistent with the classical theory of island biogeography, species richness increased with island size, decreased with island isolation, and remained relatively constant over time. Additionally, our inventory finds that almost half of the known Massachusetts ant fauna can be collected in the BHI, and identifies four new species records for Massachusetts, including one new to the United States, Myrmica scabrinodis. We find that the number of species actually active on islands depended greatly on the timescale under consideration. The species that could be detected during any given week of sampling could by no means account for total island species richness, even when correcting for sampling effort. Though we consistently collected the same number of species over any given week of sampling, the identities of those species varied greatly between weeks. This variation does not result from local immigration and extinction of species, nor from seasonally-driven changes in the abundance of individual species, but rather from weekly changes in the distribution and activity of foraging ants. This variation can be upwards of 50% of ant species per week. This suggests that numerous ant species on the BHI share the same physical space at different times. This temporal partitioning could well explain such unexpectedly high ant diversity in an isolated, urban site.

  16. The effects of biogeography on ant diversity and activity on the Boston Harbor Islands, Massachusetts, U.S.A.

    Science.gov (United States)

    Clark, Adam T; Rykken, Jessica J; Farrell, Brian D

    2011-01-01

    Many studies have examined how island biogeography affects diversity on the scale of island systems. In this study, we address how diversity varies over very short periods of time on individual islands. To do this, we compile an inventory of the ants living in the Boston Harbor Islands National Recreation Area, Boston, Massachusetts, USA using data from a five-year All Taxa Biodiversity Inventory of the region's arthropods. Consistent with the classical theory of island biogeography, species richness increased with island size, decreased with island isolation, and remained relatively constant over time. Additionally, our inventory finds that almost half of the known Massachusetts ant fauna can be collected in the BHI, and identifies four new species records for Massachusetts, including one new to the United States, Myrmica scabrinodis. We find that the number of species actually active on islands depended greatly on the timescale under consideration. The species that could be detected during any given week of sampling could by no means account for total island species richness, even when correcting for sampling effort. Though we consistently collected the same number of species over any given week of sampling, the identities of those species varied greatly between weeks. This variation does not result from local immigration and extinction of species, nor from seasonally-driven changes in the abundance of individual species, but rather from weekly changes in the distribution and activity of foraging ants. This variation can be upwards of 50% of ant species per week. This suggests that numerous ant species on the BHI share the same physical space at different times. This temporal partitioning could well explain such unexpectedly high ant diversity in an isolated, urban site.

  17. Event-Related Household Discussions Following the Boston Marathon Bombing and Associated Posttraumatic Stress Among Area Youth.

    Science.gov (United States)

    Carpenter, Aubrey L; Elkins, R Meredith; Kerns, Caroline; Chou, Tommy; Greif Green, Jennifer; Comer, Jonathan S

    2017-01-01

    Despite research documenting the scope of disaster-related posttraumatic stress (PTS) in youth, less is known about how family processes immediately postdisaster might associate with child outcomes. The 2013 Boston Marathon bombing affords a unique opportunity to assess links between immediate family discussions about community trauma and child mental health outcomes. The present study examined associations between attack-related household discussions and child PTS among Boston-area youth ages 4 to 19 following the Marathon bombing (N = 460). Caregivers completed surveys 2 to 6 months postattack about immediate household discussions about the events, child exposure to potentially traumatic attack-related experiences, and child PTS. During the Marathon bombing and manhunt, there was considerable heterogeneity in household discussions across area families, and several discussion items were differentially predictive of variability in children's PTS. Specifically, after controlling for children's direct exposure to the potentially traumatic attack/manhunt events, children showed lower PTS when it was their caregivers who informed them about the attack and manhunt, and when their caregivers expressed confidence in their safety and discussed their own feelings about the manhunt with their child. Children showed higher PTS when their caregivers did not discuss the events in front of them, asked others to avoid discussing the events in front of them, and expressed concern at the time that their child might not be safe. Child age and traumatic attack/manhunt exposure moderated several links between household discussions and child PTS. Findings underscore the importance of family communication and caregiver modeling during times of community threat and uncertainty.

  18. AS PAISAGENS CÁRSTICAS DA FLÓRIDA, EUA

    Directory of Open Access Journals (Sweden)

    Robert Brinkmann

    2008-01-01

    Full Text Available Karst landscapes typically form from the solution of soluble rocks such as limestone. In Florida, where a broad limestone platform underlies most of its territory, they are very common. The Florida¿s karst landscape can be classified as a "covered karst landscape," considering that the soluble rock that drives to the diversity of landscape is covered by non-soluble marine sediments. The most important forms in those landscapes are sinkholes, springs and caves. Sinkholes are the most common form, and thousands of them exist in Florida. The distribution of sinkholes is not random, being less dense where the sedimentary cover is formed by coarse sediments. Sinkholes can be suddenly formed, causing grave economic damages. Springs are also very common. There are hundreds of them in Florida, and among them, 33 of 1ª magnitude (related to large discharges, what signifies the biggest concentration of 1ª magnitude springs in the world. Springs have a large importance to local economies, because their mineral water is sold as bottled water, and also because of their tourist potential. Finally, the caves, are also numerous - around 1,200 are known in Florida at present. Normally, they are situated inside the aquifer zone, possessing the deepest and longest conduits in Florida. The caves give important information about Quaternary palaeofauna and sometimes, also about American Indian habits. Beyond those three main kinds of karst landscapes, some forms of smaller expression, as temporary streams and solution valleys, also occur in the territory of Florida.

  19. Extracción de sustancias asistida por ultrasonido (EUA)

    OpenAIRE

    Rocío Azuola; Pedro Vargas

    2007-01-01

    Compuestos presentes en los vegetales con propiedades funcionales o tecnológicas, han cobrado gran importancia en los mercados de alimentos, farmacéuticos y cosméticos. Se buscan métodos eficientes, económicos y favorables al ambiente para la extracción de estas sustancias. Se ha realizado un estudio bibliográfico de las publicaciones recientes sobre diferentes métodos de extracción y su comparación a las extracciones asistidas por ultrasonido (EAU) con el fin de evaluar su eficacia y viabili...

  20. Extracción de sustancias asistida por ultrasonido (EUA

    Directory of Open Access Journals (Sweden)

    Rocío Azuola

    2007-11-01

    Full Text Available Compuestos presentes en los vegetales con propiedades funcionales o tecnológicas, han cobrado gran importancia en los mercados de alimentos, farmacéuticos y cosméticos. Se buscan métodos eficientes, económicos y favorables al ambiente para la extracción de estas sustancias. Se ha realizado un estudio bibliográfico de las publicaciones recientes sobre diferentes métodos de extracción y su comparación a las extracciones asistidas por ultrasonido (EAU con el fin de evaluar su eficacia y viabilidad industrial. Se ha encontrado que la EAU es más eficiente que los métodos de extracción tradicionales, y más económica y sencilla que los métodos de extracción no tradicionales como la extracción asistida por microondas, por lo cual se comprueba su viabilidad industrial.

  1. em arquitetura e urbanismo

    Directory of Open Access Journals (Sweden)

    Ana Maria Sala Minucci Martins

    2006-01-01

    Full Text Available Está sendo desenvolvido projeto de pesquisa denominado Geometria Fractal e suas Aplicações em Arquitetura e Urbanismo, com o fito de estudar e desenvolver ferramentas analíticas e propositivas para serem aplicadas em arquitetura e urbanismo, com base em conceitos provenientes da geometria fractal.

  2. Applicability of the CERAD neuropsychological battery to Brazilian elderly Aplicabilidade da bateria neuropsicológica CERAD em idosos brasileiros

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Ferreira Bertolucci

    2001-09-01

    Full Text Available There is a limited choice of psychometric tests for Portuguese speaking people which have been evaluated in well defined groups. A Portuguese version of CERAD neuropsychological battery was applied to a control group of healthy elderly (CG (mean age 75.1 years/ education 7.9 years, 31 Alzheimer disease (AD patients classified by clinical dementia rating (CDR as CDR1 (71.4/ 9.0 and 12 AD patients CDR 2 (74.1/ 9.3. Cut-off points were: verbal fluency-11; modified Boston naming-12; Mini-mental State Examination (MMSE -26; word list memory-13; constructional praxis-9; word recall-3, word recognition-7; praxis recall-4. There was a significant difference between CG and AD-CDR1 (pExistem poucos instrumentos psicométricos em português aplicados em grupos bem definidos. Uma versão em português da bateria neuropsicológica CERAD foi aplicada a um grupo controle de 85 idosos saudáveis (GC (média de idade 75,1/ média de educação 7,9, 31 indivíduos com doença de Alzheimer (DA classificados pela Classificação Clínica para Demência (CDR como CDR1 (71,4/ 9,0 e 12 indivíduos com DA CDR2 (74,1/ 9,3. Os pontos de corte foram: fluência verbal -- 11; teste de nomeação de Boston --12; MEEM -- 26; memória da lista de palavras -- 13; praxia construtiva -- 9; evocação de palavras -- 3; reconhecimento de palavras -- 7; evocação da praxia -- 4. Houve uma diferença significativa (p<0,0001 para todos os testes, exceto o de nomeação de Boston (p<0,368. A comparação entre AD-CDR1 e AD-CDR2 mostrou diferença apenas para o MEEM, fluência verbal e teste de nomeação de Boston. O desempenho do GC foi semelhante ao de uma população controle americana pareada para nível educacional. Estes resultados indicam que esta adaptação pode ser útil para o diagnóstico de demência inicial, mas estudos mais detalhados devem ser realizados para determinar os pontos de corte para pessoas analfabetas ou com baixa escolaridade.

  3. International EMS Systems

    DEFF Research Database (Denmark)

    Langhelle, Audun; Lossius, Hans Morten; Silfvast, Tom

    2004-01-01

    is the only country that has emergency medicine (EM) as a recognised speciality but there is a need for more fully trained specialists in EM; (4) Norway: the ordinary ground ambulance is pointed out as the weakest link in the EM chain and a health reform demands extensive co-operation between the new health...... enterprises to re-establish a nation-wide air ambulance service; (5) Sweden: to create evidence based medicine standards for treatment in emergency medicine, a better integration of all part of the chain of survival, a formalised education in EM and a nation wide physician staffed helicopter EMS (HEMS) cover....

  4. EM International. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    It is the intent of EM International to describe the Office of Environmental Restoration and Waste Management`s (EM`s) various roles and responsibilities within the international community. Cooperative agreements and programs, descriptions of projects and technologies, and synopses of visits to international sites are all highlighted in this semiannual journal. Focus on EM programs in this issue is on international collaboration in vitrification projects. Technology highlights covers: in situ sealing for contaminated sites; and remote sensors for toxic pollutants. Section on profiles of countries includes: Arctic contamination by the former Soviet Union, and EM activities with Germany--cooperative arrangements.

  5. Eficiência de utilização de água e nutrientes em plantas de feijão-de-corda irrigadas com água salina em diferentes estádios de desenvolvimento Water and nutrient use efficiency in cowpea irrigated with saline water at different growth stages

    Directory of Open Access Journals (Sweden)

    Claudivan F. de Lacerda

    2009-06-01

    Full Text Available O objetivo deste trabalho foi investigar os efeitos do uso de água salina em diferentes estádios de desenvolvimento de plantas de feijão-de-corda sobre a eficiência de utilização de água e de nutrientes. O experimento foi conduzido no campo e obedeceu ao delineamento em blocos ao acaso, com cinco tratamentos e cinco repetições. Os tratamentos empregados foram: T1 - água de poço com condutividade elétrica (CEa de 0,8 dS m-1 durante todo o ciclo; T2 - água salina (CEa de 5,0 dS m-1 durante todo o ciclo; T3, T4 e T5 - água salina de 0 a 22 dias após o plantio (DAP, de 23 a 42 DAP e de 43 a 62 DAP, respectivamente. As plantas dos tratamentos T3, T4 e T5 foram irrigadas com água de poço nas demais fases do ciclo. Aos 8; 23; 43 e 63 DAP, as plantas foram colhidas e determinaram-se a matéria seca total e de grãos, a eficiência no uso da água, considerando a produção de matéria seca total (EUA P e a produção de grãos (EUA GR, e a eficiência de utilização de nutrientes (K, Ca, N, P, Fe, Cu, Zn e Mn. A aplicação de água salina durante todo o ciclo (T2 reduziu a EUA P e a EUA GR, enquanto a aplicação de água na fase inicial do ciclo (T3 reduziu a EUA GR e a eficiência de utilização da maioria dos nutrientes. Por outro lado, a irrigação com água salina dos 23 aos 42 DAP (T4 e dos 43 aos 62 DAP (T5 não afetou as eficiências nos usos de água e de nutrientes.The objective of this paper was to evaluate the effect of the saline water applied at different development stages of cowpea plants, on water and nutrient use efficiency. The experiment was set up in the field, during the dry season. A completely randomized block design, with five treatments and five repetitions was adopted. The treatments studied were: T1 - (groundwater with electrical conductivity (ECw of 0.8 dS m-1 during the whole crop cycle; T2 - saline water (ECw = 5.0 dS m-1 during the whole crop cycle; T3, T4 and T5 - saline water from 0 to 22 days after

  6. Deficiência hídrica e aplicação de ABA nas trocas gasosas e no acúmulo de flavonoides em calêndula (Calendula officinalis L. = Water deficit and ABA application on leaf gas exchange and flavonoid content in marigold (Calendula officinalis L..

    Directory of Open Access Journals (Sweden)

    Ana Cláudia Pacheco

    2011-04-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos da deficiencia hidrica e aplicacao de acido abscisico (ABA sobre aspectos fisiologicos e teor de flavonoides em plantas de calendula. Oexperimento foi instalado em condicoes de casa-de-vegetacao com plantas envasadas. No inicio do florescimento de plantas de calendula, foram aplicados quatro intervalos de suspensao da irrigacao (irrigacao diaria; tres; seis e nove dias sem irrigar, acompanhados por tres doses de ABA (0, 10 e 100 ƒÊM. Avaliou-se o conteudo relativo de agua na folha (CRA e as trocas gasosas, utilizando-se um analisador portatil por infravermelho (A: fotossintese liquida, gs: condutancia estomatica, E: transpiracao, Ci: concentracao intercelular de CO2 e EUA: eficiencia de uso daagua. Aos nove dias sem irrigacao ocorreram reducoes significativas em todas as variaveis de trocas gasosas analisadas, independente da aplicacao de ABA. Concluiu-se que o efeito principal do ABA foi o de causar diminuicao na gs, a qual foi acompanhada de reducao em A somente quando as plantas estavam desidratadas. As intensidades de deficiencia hidrica testadas nao causaram interferencia no acumulo de flavonoides nas inflorescencias. Entretanto, o ABA restringiu a biossintese de flavonoides, tanto nas plantas-controle como nas plantas submetidas a deficiencia hidrica.The goal of this study was to evaluate the effects of water deficit and abscisic acid (ABA application on physiological parameters and flavonoid production in marigold plant. The experiment was performed under nursery conditions with potted plants. It was tested water deficit by withholding water (control . diary irrigation, 3, 6 and9 days without irrigation followed by 3 ABA concentrations (0, 10 e 100 ƒÊM applied in the beginning of blooming. It was evaluated the relative water content and the leaf gas exchange using a portable infrared gas analyzer (A: net photosynthesis, gs: stomatal conductance, E: transpiration, Ci: CO2 intercellular

  7. Green Synthesis of Silver Nanoparticles through Reduction with <em>Solanum> <em>xanthocarpum> L. Berry Extract: Characterization, Antimicrobial and Urease Inhibitory Activities against <em>Helicobacter> <em>pylori>

    Directory of Open Access Journals (Sweden)

    Muhammad Awais Iqbal

    2012-08-01

    Full Text Available A green synthesis route for the production of silver nanoparticles using methanol extract from <em>Solanum> <em>xanthocarpum> berry (SXE is reported in the present investigation. Silver nanoparticles (AgNps, having a surface plasmon resonance (SPR band centered at 406 nm, were synthesized by reacting SXE (as capping as well as reducing agent with AgNO3 during a 25 min process at 45 °C. The synthesized AgNps were characterized using UV–Visible spectrophotometry, powdered X-ray diffraction, and transmission electron microscopy (TEM. The results showed that the time of reaction, temperature and volume ratio of SXE to AgNO3 could accelerate the reduction rate of Ag+ and affect the AgNps size and shape. The nanoparticles were found to be about 10 nm in size, mono-dispersed in nature, and spherical in shape. <em>In> <em>vitro> anti-<em>Helicobacter> <em>pylori> activity of synthesized AgNps was tested against 34 clinical isolates and two reference strains of <em>Helicobacter> <em>pylori> by the agar dilution method and compared with AgNO3 and four standard drugs, namely amoxicillin (AMX, clarithromycin (CLA, metronidazole (MNZ and tetracycline (TET, being used in anti-<em>H.> <em>pylori> therapy. Typical AgNps sample (S1 effectively inhibited the growth of <em>H.> <em>pylori>, indicating a stronger anti-<em>H.> <em>pylori> activity than that of AgNO3 or MNZ, being almost equally potent to TET and less potent than AMX and CLA. AgNps under study were found to be equally efficient against the antibiotic-resistant and antibiotic-susceptible strains of <em>H.> <em>pylori>. Besides, in the <em>H.> <em>pylori> urease inhibitory assay, S1 also exhibited a significant inhibition. Lineweaver-Burk plots revealed that the mechanism of inhibition was noncompetitive.

  8. Longer-term vision outcomes and complications with the Boston type 1 keratoprosthesis at the University of California, Davis.

    Science.gov (United States)

    Greiner, Mark A; Li, Jennifer Y; Mannis, Mark J

    2011-08-01

    To evaluate retention of visual acuity and development of complications after Boston type 1 keratoprosthesis implantation over a longer follow-up period than previously reported. Cohort study. Forty eyes of 35 patients who underwent Boston type 1 keratoprosthesis surgery at the University of California, Davis, between 2004 and 2010. Preoperative, intraoperative, and postoperative parameters were collected and analyzed. Best-corrected visual acuity (BCVA) and postoperative complications. Preoperative visual acuity ranged from 20/150 to light perception and was ≤20/400 in 38 eyes (95%). Preoperative diagnoses included failed corneal transplants (19 eyes, 47.5%), chemical injury (10 eyes, 25%), and aniridia (5 eyes, 12.5%). Mean follow-up duration was 33.6 months (range, 5-72 months). Of 36 eyes followed for ≥1 year, 32 eyes (89%) achieved postoperative BCVA ≥20/200. Of eyes that achieved BCVA ≥20/200, at last follow-up, 19 of 32 eyes (59%) followed for ≥1 year retained BCVA ≥20/200; 16 of 27 eyes (59%) followed for ≥2 years retained BCVA ≥20/200; 7 of 14 eyes (50%) followed for ≥3 years retained BCVA ≥20/200; and 2 of 7 eyes (29%) followed for ≥4 years retained BCVA ≥20/200. End-stage glaucoma most commonly caused vision loss (7 of 13 eyes, 54%) when BCVA ≥20/200 was not retained (follow-up ≥1 year). Glaucoma was newly diagnosed in 11 eyes (27.5%); progression was noted in 9 eyes (22.5%). Glaucoma drainage device erosion occurred in 9 eyes (22.5%). Retroprosthetic membrane formed in 22 eyes (55%), 5 eyes (12.5%) developed endophthalmitis, 6 eyes (15%) developed corneal melt, 7 eyes (17.5%) underwent keratoprosthesis replacement, and 23 eyes (57.5%) required major surgery to treat postoperative complications. The initial keratoprosthesis was retained in 32 eyes (80%). Keratoprosthesis implantation remains a viable option for salvaging vision. A significant number of patients lost vision over the postoperative course. Glaucoma and

  9. Effectiveness of the Rigo Chêneau versus Boston-style orthoses for adolescent idiopathic scoliosis: a retrospective study.

    Science.gov (United States)

    Minsk, Miriam K; Venuti, Kristen D; Daumit, Gail L; Sponseller, Paul D

    2017-01-01

    Bracing can effectively treat adolescent idiopathic scoliosis (AIS), but patient outcomes have not been compared by brace type. We compared outcomes of AIS patients treated with Rigo Chêneau orthoses (RCOs) or custom-molded Boston-style thoracolumbosacral orthoses (TLSOs). We retrospectively reviewed patient records from one scoliosis center from 1999 through 2014. Patients were studied from initial treatment until skeletal maturity or surgery. Inclusion criteria were a diagnosis of AIS, initial major curve between 25° and 40°, use of an RCO or TLSO, and no previous scoliosis treatment. The study included 108 patients (93 girls) with a mean (±standard deviation) age at brace initiation of 12.5 ± 1.3 years. Thirteen patients wore an RCO, and 95 wore a TLSO. Mean pre-bracing major curves were 32.7° ± 4.8° in the RCO group and 31.4° ± 4.4° in the TLSO group (p = 0.387). Mean brace wear time was similar between groups. Mean differences in major curve from baseline to follow-up were -0.4° ± 9.9° in the RCO group and 6.9° ± 12.1° in the TLSO group (p = 0.028). Percent changes in major curve from baseline to follow-up were 0.0% ± 30.5% for the RCO group and 21.3% ± 38.8% for the TLSO group (p = 0.030). No RCO patients and 34% of TLSO patients progressed to spinal surgery (p = 0.019). At follow-up, major curves improved by 6° or more in 31% of the RCO group and 13% of the TLSO group (p = 0.100). Patients treated with RCOs compared with Boston-style TLSOs had similar baseline characteristics and brace wear time yet significantly lower rates of spinal surgery. Patients with RCOs also had lower mean and percent major curve progression versus those with TLSOs.

  10. The Boston Marathon bombing: after-action review of the Brigham and Women's Hospital emergency radiology response.

    Science.gov (United States)

    Brunner, John; Rocha, Tatiana C; Chudgar, Avni A; Goralnick, Eric; Havens, Joaquim M; Raja, Ali S; Sodickson, Aaron

    2014-10-01

    To analyze imaging utilization and emergency radiology process turnaround times in response to the April 15, 2013, Boston Marathon bombing in order to identify opportunities for improvement in the Brigham and Women's Hospital (BWH) emergency operations plan. Institutional review board approval was obtained with waivers of informed consent. Patient demographics, injuries, and outcomes were gathered, along with measures of emergency department (ED) imaging utilization and turnaround times, which were compared with operations from the preceding year by using the Wilcoxon rank sum test. Multivariate linear regression was used to assess contributors to examination cancellations. Forty patients presented to BWH after the bombing; 16 were admitted and 24 were discharged home. There were no fatalities. Ten patients required emergent surgery. Blast injury types included 13 (33%) primary, 20 (51%) secondary, three (8%) tertiary, and 19 (49%) quaternary. Thirty-one patients (78%) underwent imaging in the ED; 57 radiographic examinations in 30 patients and 16 computed tomographic (CT) examinations in seven patients. Sixty-two radiographic and 14 CT orders were cancelled. Median time from blast to patient arrival was 97 minutes (interquartile range [IQR], 43-139 minutes), patient arrival to ED examination order, 24 minutes (IQR, 12-50 minutes), order to examination completion, 49 minutes (IQR, 26-70 minutes), and examination completion to available dictated text report, 75 minutes (IQR, 19-147 minutes). Examination completion turnaround times were significantly increased for radiography (52 minutes [IQR, 26-73 minutes] vs annual median, 31 minutes [IQR, 19-48 minutes]; P = .001) and decreased for CT (37 minutes [IQR, 26-50 minutes] vs annual median, 72 minutes [IQR, 40-129 minutes]; P = .001). There were no significant differences in report availability turnaround time (75 minutes [IQR, 19-147 minutes] vs annual median, 74 minutes [IQR, 35-127 minutes]; P = .34). The surge in

  11. Evaluation of the stability of Boston type I keratoprosthesis-donor cornea interface using anterior segment optical coherence tomography.

    Science.gov (United States)

    Garcia, Julian P S; Ritterband, David C; Buxton, Douglas F; De la Cruz, Jose

    2010-09-01

    To evaluate the anatomic stability of an implanted Boston type I keratoprosthesis (KPro)-donor cornea interface and assess the presence or absence of a potential space (gap) between the KPro front plate and donor cornea using anterior segment optical coherence tomography (AS-OCT). The presence of a gap would raise concerns of a possible pathway for the exchange of extraocular fluid with the anterior chamber. Fifteen eyes implanted with a Boston type I KPro were studied by the noncontact technique of AS-OCT (AC Cornea OCT prototype; OTI, Canada). All the KPro devices had been implanted at least 4 weeks before the study (mean: 7 months, range: 1-22 months). Eight eyes had aphakic Kpros, and the other 7 had pseudophakic implants. Anesthetized eyes were imaged before and during pressure application using sterile cotton-tip applicators. Pressure was applied for 10 seconds on the nasal or temporal side of the eye. Images were analyzed for any possible changes in the KPro-donor cornea interface during the application of pressure. Of 15 eyes, 10 had the threaded front plate model with a T-shaped silhouette and corrugated sides, whereas 5 had the threadless type with a T-shaped silhouette and smooth sides on cross-sectional optical coherence tomography. Of the 15 eyes, 2 revealed a gap between the front plate and the surface of the donor cornea. The rest revealed no gaps. With pressure, none of the eyes, including the 2 with gaps, demonstrated any change in the KPro-donor cornea interface during dynamic imaging (eg, gaping or evidence of fluid escape along the KPro-donor cornea borders). In all eyes, the position of the titanium locking ring was visible and verified to be in an adequate position. The implanted KPro-donor cornea interface seems to be stable dynamically using AS-OCT. A gap that has been documented with this imaging tool showed neither gaping nor escape of anterior chamber fluid during dynamic cross-sectional imaging. Further studies will be needed to assess

  12. Report on a Boston University Conference December 7-8, 2012 on 'How Can the History and Philosophy of Science Contribute to Contemporary U.S. Science Teaching?'

    CERN Document Server

    Garik, Peter

    2015-01-01

    This is an editorial report on the outcomes of an international conference sponsored by a grant from the National Science Foundation (NSF) (REESE-1205273) to the School of Education at Boston University and the Center for Philosophy and History of Science at Boston University for a conference titled: How Can the History and Philosophy of Science Contribute to Contemporary U.S. Science Teaching? The presentations of the conference speakers and the reports of the working groups are reviewed. Multiple themes emerged for K-16 education from the perspective of the history and philosophy of science. Key ones were that: students need to understand that central to science is argumentation, criticism, and analysis; students should be educated to appreciate science as part of our culture; students should be educated to be science literate; what is meant by the nature of science as discussed in much of the science education literature must be broadened to accommodate a science literacy that includes preparation for soci...

  13. O intelectual universitário e seu trabalho em tempos de "pesquisa administrada" University scholars and their work in times of "administered research"

    Directory of Open Access Journals (Sweden)

    Lucídio Bianchetti

    2012-09-01

    Full Text Available T. Adorno, ao chegar aos EUA na década de 1940, surpreende-se com o novo ethos da pesquisa com o qual se defronta e estranha os mecanismos de controle que pesavam sobre a academia e os pesquisadores. Nos EUA, esses mecanismos convergiram para uma síntese contida na fórmula "publish or perish", processo que acabou instaurando-se no Brasil a partir de meados da década de 1990. É sobre esse processo, ao qual foram submetidos os intelectuais na universidade e as consequências para a produção e veiculação do conhecimento, que dedicamos nossa atenção neste texto. Por meio deste artigo, objetivamos investigar a forma como a produção intelectual vem desenvolvendo-se em tempos nos quais a pesquisa científica torna-se cada vez mais administrada pela lógica do fetiche da mercadoria cultural, com destaque para a análise do modo como a lógica do publique ou pereça delineia a forma da produção científica no Brasil.Upon arriving in the United States in the 1940s, Theodor Adorno was surprised with the new research ethos he found and perplexed by the various control mechanisms that influenced the academy and its researchers. He began to realize their implications on the quality of research process and product and the education of future researchers. In the USA, these changes converged towards a synthesis expressed by the formula "publish or perish," a process that was instilled in Brazil as from the mid-1990s, with all of the consequences that had been identified in other spaces. This article analyzes the transformations university scholars were submitted to and their consequences on knowledge production and dissemination. The article investigates how intellectual production is undertaken at a time in which scientific research has become increasingly administered under the logic of the fetish of cultural merchandise. It also analyzes how the "publish or perish" logic influences the form of scientific production in Brazil.

  14. Acid-base disturbances in nephrotic syndrome: analysis using the CO2/HCO3 method (traditional Boston model) and the physicochemical method (Stewart model).

    Science.gov (United States)

    Kasagi, Tomomichi; Imai, Hirokazu; Miura, Naoto; Suzuki, Keisuke; Yoshino, Masabumi; Nobata, Hironobu; Nagai, Takuhito; Banno, Shogo

    2017-10-01

    The Stewart model for analyzing acid-base disturbances emphasizes serum albumin levels, which are ignored in the traditional Boston model. We compared data derived using the Stewart model to those using the Boston model in patients with nephrotic syndrome. Twenty-nine patients with nephrotic syndrome and six patients without urinary protein or acid-base disturbances provided blood and urine samples for analysis that included routine biochemical and arterial blood gas tests, plasma renin activity, and aldosterone. The total concentration of non-volatile weak acids (ATOT), apparent strong ion difference (SIDa), effective strong ion difference (SIDe), and strong ion gap (SIG) were calculated according to the formulas of Agrafiotis in the Stewart model. According to the Boston model, 25 of 29 patients (90%) had alkalemia. Eighteen patients had respiratory alkalosis, 11 had metabolic alkalosis, and 4 had both conditions. Only three patients had hyperreninemic hyperaldosteronism. The Stewart model demonstrated respiratory alkalosis based on decreased PaCO2, metabolic alkalosis based on decreased ATOT, and metabolic acidosis based on decreased SIDa. We could diagnose metabolic alkalosis or acidosis with a normal anion gap after comparing delta ATOT [(14.09 - measured ATOT) or (11.77 - 2.64 × Alb (g/dL))] and delta SIDa [(42.7 - measured SIDa) or (42.7 - (Na + K - Cl)]). We could also identify metabolic acidosis with an increased anion gap using SIG > 7.0 (SIG = 0.9463 × corrected anion gap-8.1956). Patients with nephrotic syndrome had primary respiratory alkalosis, decreased ATOT due to hypoalbuminemia (power to metabolic alkalosis), and decreased levels of SIDa (power to metabolic acidosis). We could detect metabolic acidosis with an increased anion gap by calculating SIG. The Stewart model in combination with the Boston model facilitates the analysis of complex acid-base disturbances in nephrotic syndrome.

  15. Selfcoelum lamothei n. sp. (Digenea: Cyclocoelidae: Cyclocoelinae from the air sacs of the long-billed curlew, Numenius americanus (Scolopacidae, from the Galveston, Texas area, USA Selfcoelum lamothei, n. sp. (Digenea: Cyclocoelidae: Cyclocoelinae de los sacos aéreos del playero de pico largo, Numenius americanus (Scolopacidae, del área del condado de Galveston, Texas, EUA

    Directory of Open Access Journals (Sweden)

    Charles K. Blend

    2008-08-01

    Full Text Available Fourteen specimens of a new species of cyclocoelid, Selfcoelum lamothei n. sp. (Digenea: Cyclocoelidae: Cyclocoelinae, from the air sacs of a long-billed curlew, Numenius americanus Bechstein (Scolopacidae, collected from the Galveston area, Galveston County, Texas, USA, were examined. The new species has an intertesticular ovary that forms a triangle with the testes, placing it in Cyclocoelinae Stossich, 1902. The new species is most similar to Selfcoelum capellum (Khan, 1935 n. comb., but differs from this species by lacking an oral sucker and by having a somewhat larger ovary, larger testes, a smaller posttesticular space, a larger cirrus sac, larger eggs, and the vitelline follicles of S. lamothei n. sp. are more bulky making the vitelline fields more laterally extensive, and more anteriorly distributed (reaching anteriorly to the level of the pharynx compared to the level of the cecal bifurcation than those of S. capellum. The new species can be distinguished from the 2 species currently assigned to Selfcoelum Dronen, Gardner and Jiménez, 2006, S. brasilianum (Stossich, 1902 and S. limnodromi Dronen, Gardner and Jiménez, 2006, by having an intercecal uterus rather than having uterine loops that overreach the ceca laterally. The genus Selfcoelum should be emended to include those species where the uterus is either intercecal or where the uterine loops overreach the ceca laterally and those species with or without an oral sucker.Se examinaron 14 ejemplares de una nueva especie de ciclocélido, Selfcoelum lamothei n. sp. (Digenea: Cyclocoelidae: Cyclocoelinae que es parásito de los sacos aéreos del playero de pico largo, Numenius americanus Bechstein (Scolopacidae, recolectados en el condado de Galveston, Texas, EUA. La especie nueva se caracteriza por presentar el ovario en posición intertesticular, formando un triángulo con relación a los testículos. Este rasgo sitúa a la nueva especie entre los Cyclocoelinae Stossich, 1902

  16. What it Takes to Get Passed On: Message Content, Style, and Structure as Predictors of Retransmission in the Boston Marathon Bombing Response.

    Science.gov (United States)

    Sutton, Jeannette; Gibson, C Ben; Spiro, Emma S; League, Cedar; Fitzhugh, Sean M; Butts, Carter T

    2015-01-01

    Message retransmission is a central aspect of information diffusion. In a disaster context, the passing on of official warning messages by members of the public also serves as a behavioral indicator of message salience, suggesting that particular messages are (or are not) perceived by the public to be both noteworthy and valuable enough to share with others. This study provides the first examination of terse message retransmission of official warning messages in response to a domestic terrorist attack, the Boston Marathon Bombing in 2013. Using messages posted from public officials' Twitter accounts that were active during the period of the Boston Marathon bombing and manhunt, we examine the features of messages that are associated with their retransmission. We focus on message content, style, and structure, as well as the networked relationships of message senders to answer the question: what characteristics of a terse message sent under conditions of imminent threat predict its retransmission among members of the public? We employ a negative binomial model to examine how message characteristics affect message retransmission. We find that, rather than any single effect dominating the process, retransmission of official Tweets during the Boston bombing response was jointly influenced by various message content, style, and sender characteristics. These findings suggest the need for more work that investigates impact of multiple factors on the allocation of attention and on message retransmission during hazard events.

  17. What it Takes to Get Passed On: Message Content, Style, and Structure as Predictors of Retransmission in the Boston Marathon Bombing Response.

    Directory of Open Access Journals (Sweden)

    Jeannette Sutton

    Full Text Available Message retransmission is a central aspect of information diffusion. In a disaster context, the passing on of official warning messages by members of the public also serves as a behavioral indicator of message salience, suggesting that particular messages are (or are not perceived by the public to be both noteworthy and valuable enough to share with others. This study provides the first examination of terse message retransmission of official warning messages in response to a domestic terrorist attack, the Boston Marathon Bombing in 2013. Using messages posted from public officials' Twitter accounts that were active during the period of the Boston Marathon bombing and manhunt, we examine the features of messages that are associated with their retransmission. We focus on message content, style, and structure, as well as the networked relationships of message senders to answer the question: what characteristics of a terse message sent under conditions of imminent threat predict its retransmission among members of the public? We employ a negative binomial model to examine how message characteristics affect message retransmission. We find that, rather than any single effect dominating the process, retransmission of official Tweets during the Boston bombing response was jointly influenced by various message content, style, and sender characteristics. These findings suggest the need for more work that investigates impact of multiple factors on the allocation of attention and on message retransmission during hazard events.

  18. Boston scleral lens prosthetic device for treatment of severe dry eye in chronic graft-versus-host disease.

    Science.gov (United States)

    Jacobs, Deborah S; Rosenthal, Perry

    2007-12-01

    To determine if the Boston Scleral Lens Prosthetic Device (BSLPD) reduces symptoms and improves quality of life in patients with severe dry eye from chronic graft-versus-host disease (cGvHD). This is a noncomparative interventional case series reporting 33 consecutive patients with severe dry eye from cGvHD, unresponsive to conventional therapy, who were fitted with the BSLPD. A patient survey was undertaken after lenses were dispensed and worn regarding the effect of scleral lens wear on their symptoms, quality of life, and activities of daily living. The patient population was characterized from a retrospective chart review. Survey data were tabulated. BSLPD wear resulted in improvement in pain, photophobia, and general quality of life in nearly all patients, with more than half reporting the highest improvement level for pain (52%) and photophobia (63%), and more than two thirds (73%) reporting the highest improvement level for quality of life. There was improvement in reading and driving in >90% of those who reported previous compromise, with >60% reporting the highest improvement level for each of these activities. The BSLPD mitigates symptoms and improves quality of life in patients with severe dry eye from cGHvD.

  19. Identifying sources of children's consumption of junk food in Boston after-school programs, April-May 2011.

    Science.gov (United States)

    Kenney, Erica L; Austin, S Bryn; Cradock, Angie L; Giles, Catherine M; Lee, Rebekka M; Davison, Kirsten K; Gortmaker, Steven L

    2014-11-20

    Little is known about how the nutrition environment in after-school settings may affect children's dietary intake. We measured the nutritional quality of after-school snacks provided by programs participating in the National School Lunch Program or the Child and Adult Care Food Program and compared them with snacks brought from home or purchased elsewhere (nonprogram snacks). We quantified the effect of nonprogram snacks on the dietary intake of children who also received program-provided snacks during after-school time. Our study objective was to determine how different sources of snacks affect children's snack consumption in after-school settings. We recorded snacks served to and brought in by 298 children in 18 after-school programs in Boston, Massachusetts, on 5 program days in April and May 2011. We measured children's snack consumption on 2 program days using a validated observation protocol. We then calculated within-child change-in-change models to estimate the effect of nonprogram snacks on children's dietary intake after school. Nonprogram snacks contained more sugary beverages and candy than program-provided snacks. Having a nonprogram snack was associated with significantly higher consumption of total calories (+114.7 kcal, P foods with added sugars (+0.5 servings; P foods and nearly twice as many calories than on days when they consumed only program-provided snacks. Policy strategies limiting nonprogram snacks or setting nutritional standards for them in after-school settings should be explored further as a way to promote child health.

  20. Infant lead poisoning associated with use of tiro, an eye cosmetic from Nigeria--Boston, Massachusetts, 2011.

    Science.gov (United States)

    2012-08-03

    Lead is highly toxic and can damage the brain, kidneys, bone marrow, and other body systems; high levels can cause convulsions, coma, and death. Young children are especially susceptible to lead exposures because of their floor-hand-mouth activity, greater gut absorption, and developing central nervous systems. In June 2011, a male infant aged 6 months of Nigerian descent was referred to the Pediatric Environmental Health Specialty Unit (PEHSU) at Boston Children's Hospital because of an elevated blood lead level (BLL). An investigation found no lead exposure except for "tiro," a Nigerian cosmetic that also is used as a folk remedy to promote visual development. The tiro applied to the infant's eyelids contained 82.6% lead. Products similar to tiro, such as "surma" and "kajal" in Asia and kohl in the Middle East, also might contain lead. This case adds to the medical literature documenting nonpaint lead sources as causes of elevated BLLs in children and highlights persons of certain immigrant populations as a risk group. Educational efforts are needed to inform immigrants from Africa, Asia, and the Middle East that tiro and similar products can cause lead poisoning in children. Health-care providers and public health workers should ask about eye cosmetics and folk remedies when seeking a source of exposure in children with elevated BLLs from certain immigrant populations.

  1. Biogeographic ancestry is associated with higher total body adiposity among African-American females: the Boston Area Community Health Survey.

    Science.gov (United States)

    Goonesekera, Sunali D; Fang, Shona C; Piccolo, Rebecca S; Florez, Jose C; McKinlay, John B

    2015-01-01

    The prevalence of obesity is disproportionately higher among African-Americans and Hispanics as compared to whites. We investigated the role of biogeographic ancestry (BGA) on adiposity and changes in adiposity in the Boston Area Community Health Survey. We evaluated associations between BGA, assessed via Ancestry Informative Markers, and adiposity (body mass index (BMI), percent body fat (PBF), and waist-to-hip ratio (WHR)) and changes in adiposity over 7 years for BMI and WHR and 2.5 years for PBF, per 10% greater proportion of BGA using multivariable linear regression. We also examined effect-modification by demographic and socio-behavioral variables. We observed positive associations between West-African ancestry and cross-sectional BMI (percent difference=0.62%; 95% CI: 0.04%, 1.20%), and PBF (β=0.35; 95% CI: 0.11, 0.58). We also observed significant effect-modification of the association between West-African ancestry and BMI by gender (p-interaction: women. We observed no main associations between Native-American ancestry and adiposity but observed significant effect-modification of the association with BMI by diet (p-interaction: ancestry may contribute to high prevalence of total body adiposity among African-Americans, particularly African-American women.

  2. Radiocarbon-Dated Pollen and Sediment Records From Near the Boylston Street Fishweir Site in Boston, Massachusetts

    Science.gov (United States)

    Newby, Paige E.; Webb, Thompson

    1994-03-01

    A radiocarbon-dated pollen record near the Boylston Street Fishweir site in Boston; Massachusetts, provides a regional and local record of vegetation changes from the middle Holocene to present. The stratigraphy begins about 5630 ± 90 yr B.P. with a marine transgression and is continuous up to the historic backfilling of the Back Bay area about 100 yr B.P. When pollen began accumulating at the site, the immediate area resembled the swamp forests growing today in southern New England. Fresh- and brackish-water vegetation was present before the area near the site was submerged. While these vegetation changes occurred locally, oak forest grew in the region. Correlation of this stratigraphy with archaeological data collected from 500 Boylston Street indicates that between 4700 and 3700 yr B.P., a number of fence-like alignments ("weirs"), were probably placed within existing channels and/or along shorelines to capture fish and other marine animals as they moved with the tidal flow.

  3. Culture qualitatively but not quantitatively influences performance in the Boston naming test in a chinese-speaking population.

    Science.gov (United States)

    Chen, Ting-Bin; Lin, Chi-Ying; Lin, Ker-Neng; Yeh, Yen-Chi; Chen, Wei-Ta; Wang, Kuo-Shu; Wang, Pei-Ning

    2014-01-01

    The Boston Naming Test (BNT) is the most frequently administered confrontational naming test, but the cultural background of the patients may influence their performance in the BNT. The aim of this study was to identify differences in performance in the BNT between a Chinese population in Taiwan, Chinese populations in other areas and a Caucasian population. A total of 264 native, Chinese-speaking, cognitively normal elders aged >60 years were enrolled in our study and conducted the 30-item Chinese version of the BNT. Another 10 BNT studies were categorized, analyzed and compared with the present study. Higher education was associated with higher scores, whereas age and gender had no effect on performance in the BNT. The score of the Chinese-speaking population was equivalent to the English-speaking population. A disparity in difficulties with items was not only apparent between the Taiwanese and Caucasian populations, but also between the Chinese-speaking populations in the different geographic areas. For the most part, the impact of culture on performance in the BNT may not be quantitative but qualitative. Attention should be paid to a potential effect of culture on difficulties with items when administering the BNT to non-English-speaking populations. Understanding differences in performance in the BNT in distinct cultural settings improves the clinical application of the BNT.

  4. A Health Impact Assessment of Proposed Public Transportation Service Cuts and Fare Increases in Boston, Massachusetts (U.S.A.

    Directory of Open Access Journals (Sweden)

    Peter James

    2014-08-01

    Full Text Available Transportation decisions have health consequences that are often not incorporated into policy-making processes. Health Impact Assessment (HIA is a process that can be used to evaluate health effects of transportation policy. We present a rapid HIA, conducted over eight weeks, evaluating health and economic effects of proposed fare increases and service cuts to Boston, Massachusetts’ public transportation system. We used transportation modeling in concert with tools allowing for quantification and monetization of multiple pathways. We estimated health and economic costs of proposed public transportation system changes to be hundreds of millions of dollars per year, exceeding the budget gap the public transportation authority was required to close. Significant health pathways included crashes, air pollution, and physical activity. The HIA enabled stakeholders to advocate for more modest fare increases and service cuts, which were eventually adopted by decision makers. This HIA was among the first to quantify and monetize multiple pathways linking transportation decisions with health and economic outcomes, using approaches that could be applied in different settings. Including health costs in transportation decisions can lead to policy choices with both economic and public health benefits.

  5. [Working effectively towards rehabilitation goals: long-term outcome of a randomised controlled trial of the Boston psychiatric rehabilitation approach].

    Science.gov (United States)

    van Busschbach, J T; Swildens, W; Michon, H; Kroon, H; Koeter, M; Wiersma, D; van Os, J

    2016-01-01

    In the Netherlands the Boston psychiatric rehabilitation approach (bpr) is one of the most widely implemented rehabilitation methods. So far, little research has been done on the efficacy of this approach. To investigate the effect of bpr on the attainment of personal rehabilitation goals, social functioning and empowerment and on care requirements and quality of life in persons with severe mental illness (smi) in the Netherlands. In a multicentre randomised controlled trial (rct: isrctn73683215) patients with smi were randomly assigned to bpr (n = 80) or 'care as usual' (cau; n = 76). The primary outcome was the attainment of the rehabilitation goal as formulated by the patient. The secondary outcomes were a change in the work situation and in the degree of independent living, in care requirements (Camberwell Assessment of Needs), in empowerment (Personal Empowerment Scale) and in the quality of life (who-qol). The effects were tested at 12 and 24 months. The degree of goal attainment was substantially higher in bpr at both 12 months (adjusted risk difference: 16%; 95%ci, 2 to 31; nnt = 7) and 24 months (adjusted risk difference: 21%, 95%ci, 4% to 38%; nnt = 5). The approach was also more effective in the area of societal participation (bpr: 21% adjusted increase, cau: 0% adjusted increase; nnt = 5), but not in the other secondary outcome measures. The results suggest that bpr is effective in supporting patients with smi to reach self-formulated rehabilitation goals and in enhancing their societal participation.

  6. Effects of urbanization on benthic macroinvertebrate assemblages in contrasting environmental settings: Boston, Massachusetts; Birmingham, Alabama; and Salt Lake City, Utah

    Science.gov (United States)

    Cuffney, T.F.; Zappia, H.; Giddings, E.M.P.; Coles, J.F.

    2005-01-01

    Responses of invertebrate assemblages along gradients of urban intensity were examined in three metropolitan areas with contrasting climates and topography (Boston, Massachusetts; Birmingham, Alabama; Salt Lake City, Utah). Urban gradients were defined using an urban intensity index (UII) derived from basin-scale population, infrastructure, land-use, land-cover, and socioeconomic characteristics. Responses based on assemblage metrics, indices of biotic integrity (B-IBI), and ordinations were readily detected in all three urban areas and many responses could be accurately predicted simply using regional UIIs. Responses to UII were linear and did not indicate any initial resistance to urbanization. Richness metrics were better indicators of urbanization than were density metrics. Metrics that were good indicators were specific to each study except for a richness-based tolerance metric (TOLr) and one B-IBI. Tolerances to urbanization were derived for 205 taxa. These tolerances differed among studies and with published tolerance values, but provided similar characterizations of site conditions. Basin-scale land-use changes were the most important variables for explaining invertebrate responses to urbanization. Some chemical and instream physical habitat variables were important in individual studies, but not among studies. Optimizing the study design to detect basin-scale effects may have reduced the ability to detect local-scale effects. ?? 2005 by the American Fisheries Society.

  7. Culture Qualitatively but Not Quantitatively Influences Performance in the Boston Naming Test in a Chinese-Speaking Population

    Directory of Open Access Journals (Sweden)

    Ting-Bin Chen

    2014-04-01

    Full Text Available Background/Aims: The Boston Naming Test (BNT is the most frequently administered confrontational naming test, but the cultural background of the patients may influence their performance in the BNT. The aim of this study was to identify differences in performance in the BNT between a Chinese population in Taiwan, Chinese populations in other areas and a Caucasian population. Methods: A total of 264 native, Chinese-speaking, cognitively normal elders aged >60 years were enrolled in our study and conducted the 30-item Chinese version of the BNT. Another 10 BNT studies were categorized, analyzed and compared with the present study. Results: Higher education was associated with higher scores, whereas age and gender had no effect on performance in the BNT. The score of the Chinese-speaking population was equivalent to the English-speaking population. A disparity in difficulties with items was not only apparent between the Taiwanese and Caucasian populations, but also between the Chinese-speaking populations in the different geographic areas. Conclusion: For the most part, the impact of culture on performance in the BNT may not be quantitative but qualitative. Attention should be paid to a potential effect of culture on difficulties with items when administering the BNT to non-English-speaking populations. Understanding differences in performance in the BNT in distinct cultural settings improves the clinical application of the BNT.

  8. Stormwater permitting for a large construction project: NPDES and Boston's Central Artery/Tunnel

    Energy Technology Data Exchange (ETDEWEB)

    Bryan, B.B. (BSC Group, Boston, MA (United States))

    1993-01-01

    The promulgation of EPA's NPDES stormwater discharge regulations occurred during the latter planning stages for Boston's Central Artery/Tunnel Project, making this project, one of the largest single urban highway projects ever built, one of the first to be permitted under new regulations. The Project consists of 128 land miles of new highway, including numerous ramps and interchanges, and a harbor tunnel, with stormwater discharging during construction from at least 38 separate points. Complicating the permitting situation, stormwater is combined with dewatering discharges from excavations in filled and former industrial areas. Working closely with EPA Region 1 and the Massachusetts Department of Environmental Protection, the Massachusetts Highway Department submitted a permit application combining estimates of dewatering discharge quality derived from groundwater sampling with all the elements of a NPDES application for construction stormwater. The resulting permit contained two separate sets of monitoring requirements for the same discharge points, one for stormwater and one for dewatering. Quarterly monitoring was required for both dewatering and stormwater for metals, suspended solids, TPH, and VOC. Limits of 50 mg/1 TSS and 5 mg/1 TPH were established for dewatering only.

  9. A health impact assessment of proposed public transportation service cuts and fare increases in Boston, Massachusetts (U.S.A.).

    Science.gov (United States)

    James, Peter; Ito, Kate; Buonocore, Jonathan J; Levy, Jonathan I; Arcaya, Mariana C

    2014-08-07

    Transportation decisions have health consequences that are often not incorporated into policy-making processes. Health Impact Assessment (HIA) is a process that can be used to evaluate health effects of transportation policy. We present a rapid HIA, conducted over eight weeks, evaluating health and economic effects of proposed fare increases and service cuts to Boston, Massachusetts' public transportation system. We used transportation modeling in concert with tools allowing for quantification and monetization of multiple pathways. We estimated health and economic costs of proposed public transportation system changes to be hundreds of millions of dollars per year, exceeding the budget gap the public transportation authority was required to close. Significant health pathways included crashes, air pollution, and physical activity. The HIA enabled stakeholders to advocate for more modest fare increases and service cuts, which were eventually adopted by decision makers. This HIA was among the first to quantify and monetize multiple pathways linking transportation decisions with health and economic outcomes, using approaches that could be applied in different settings. Including health costs in transportation decisions can lead to policy choices with both economic and public health benefits.

  10. FOX: A Fault-Oblivious Extreme-Scale Execution Environment Boston University Final Report Project Number: DE-SC0005365

    Energy Technology Data Exchange (ETDEWEB)

    Appavoo, Jonathan [Boston Univ., MA (United States)

    2013-03-17

    Exascale computing systems will provide a thousand-fold increase in parallelism and a proportional increase in failure rate relative to today's machines. Systems software for exascale machines must provide the infrastructure to support existing applications while simultaneously enabling efficient execution of new programming models that naturally express dynamic, adaptive, irregular computation; coupled simulations; and massive data analysis in a highly unreliable hardware environment with billions of threads of execution. The FOX project explored systems software and runtime support for a new approach to the data and work distribution for fault oblivious application execution. Our major OS work at Boston University focused on developing a new light-weight operating systems model that provides an appropriate context for both multi-core and multi-node application development. This work is discussed in section 1. Early on in the FOX project BU developed infrastructure for prototyping dynamic HPC environments in which the sets of nodes that an application is run on can be dynamically grown or shrunk. This work was an extension of the Kittyhawk project and is discussed in section 2. Section 3 documents the publications and software repositories that we have produced. To put our work in context of the complete FOX project contribution we include in section 4 an extended version of a paper that documents the complete work of the FOX team.

  11. Boat-Based Education for Boston Area Public Schools: Encouraging Marine Science and Technology Literacy and Awareness of the Coastal "Backyard"

    Science.gov (United States)

    Howard, E. M.; Reynolds, R. M.; Wright, A. K.; Deschenes, H. A.

    2016-02-01

    Half the global population lives within 60 km of the ocean, profoundly influencing environmental quality and services to local communities. Adoption of marine science curricula creates opportunities for educators and scientists to engage and entrain K-12 students as ocean stewards. In particular, boat-based science activities facilitate hands-on inquiry. These activities reinforce key science concepts while creating a tangible connection to our shared coastal "backyard." A collaboration between Zephyr Education Foundation, the New England Aquarium, the University of Massachusetts Boston and Woods Hole Oceanographic Institution has taken >500 Boston, MA area students from 26 public schools on boat-based education trips in Boston Harbor. Marine science and technology professionals and educators facilitate participatory activities using modern marine technology aboard a research vessel. Trips are funded at no cost to participants by a grant from the Richard Lounsbery Foundation; cost-free outings are essential for participation from underserved public school districts. Participants perceived three important outcomes of their outings: the trips 1) enhanced in-class curricular learning and improved marine science literacy 2) increased personal connections to local marine environments, and 3) increased interest in careers in marine science, including engineering and technical positions. Despite living in close proximity to water, this was the first boat outing for many students; boat-based education trips enhanced student awareness of local environments in a way that curricular study had not. Boston trip results are being evaluated, but 3000 evaluations from similar trips in Woods Hole, MA indicate that 98% of participants gained a better understanding and appreciation of the work conducted by marine scientists, engineers, and other professionals, and 82% said their experience made them more interested in becoming involved in science at school and/or as a job. In summary

  12. Emergency Medical Service (EMS) Stations

    Data.gov (United States)

    Kansas Data Access and Support Center — EMS Locations in Kansas The EMS stations dataset consists of any location where emergency medical services (EMS) personnel are stationed or based out of, or where...

  13. La Matriz BCG (Boston Consulting Group para la Gestión de Publicaciones Periádicas The BCG (Boston Consulting Group matrix for management of periodic publications

    Directory of Open Access Journals (Sweden)

    Mª del Pilar Serrano Gallardo

    2005-11-01

    Full Text Available El marketing documental se ha de encargar de satisfacer las necesidades informativas de los usuarios de forma rentable para ellos y para el centro; para ello se ha de partir de un conjunto de herramientas técnicas que se conocen como el Marketing - Mix, y que abarcan el Producto, el Precio, la Distribución y la Comunicación. Dentro de las herramientas destinadas al producto se encuentra la matriz BCG (Boston Consulting Group, que está orientada a gestión, sobre la base de la situación del producto en el mercado. El objetivo del presente artículo es proponer una matriz BCG para la gestión de una publicación periódica enfermera en nuestro mercado.La matriz BCG se construye con dos variables: el Crecimiento del Mercado y la Tasa Relativa del Mercado, las cuales se han operacionalizado como Media de Crecimiento Anual en el número de suscripciones de tres revistas enfermeras (Rol de Enfermería, Metas de Enfermería y Nursing durante el último quinquenio y Media de Tirada Actual de las tres publicaciones. Se han utilizado datos ofrecidos por la Oficina para el Control de la Difusión (OJD. La matriz BCG puede constituirse como herramienta básica en la gestión de publicaciones, dado que tras determinar la situación del producto, se pueden establecer estrategias que ayuden o favorezcan el mejor posicionamiento posible del producto en el mercado.Documentary marketing has to address the information needs of the users in a manner that is cost-effective not only for them but also for the institution. To do this, a set of technical tools, known as Marketing- Mix, need to be used. These tools include the Product, Price, Distribution and Communication. Within the set of tools used for the Product, we find the BCG matrix (Boston Consulting Group, a tool aimed at the management of the product on the basis of where it is positioned in the market. The objective of this paper is to propose a BCG matrix for the management of a nursing periodic

  14. Iatrogenic keratoconjunctivitis sicca in a dog Ceratoconjuntivite seca iatrogênica em cão

    Directory of Open Access Journals (Sweden)

    Denise Eliza de Almeida

    2004-06-01

    Full Text Available Qualitative and quantitative abnormalities in primary components of the tear can alter the dynamics of the lacrimal film, compromising its function. Lipids, an aqueous fraction and mucoproteins constitute the lacrimal film. Keratoconjunctivitis sicca (KCS is a disease commonly diagnosed in dogs. It is characterized by the deficiency of the aqueous fraction in the lacrimal film that results in dryness, inflammation of the conjunctive and cornea with progressive corneal illness and reduction of vision and pain. Due to the significant contribution of the third eyelid lacrimal gland to the production of the aqueous fraction of the lacrimal film, the removal of this gland when prolapsed is an important cause of iatrogenic keratoconjuctivitis sicca. This paper describes a clinical case of iatrogenic keratoconjuctivitis sicca in a 10 month-old Boston Terrier which was caused by the removal of the third eyelid lacrimal gland due to its prolapse.Anormalidades quali-quantitativas em componentes primários da lágrima podem alterar a dinâmica do filme lacrimal, comprometendo sua função. O filme lacrimal é composto por lipídios, uma fração aquosa e por mucoproteínas. A ceratoconjuntivite seca (CCS é uma enfermidade freqüentemente diagnosticada em cães, caracterizada pela deficiência da fração aquosa do filme lacrimal, resultando em dessecação e inflamação da conjuntiva e córnea, dor, doença corneana progressiva e redução da visão. Devido à contribuição significativa da glândula da terceira pálpebra na produção da porção aquosa do filme lacrimal, a remoção desta glândula, quando prolapsada, constitui-se em importante causa de CCS iatrogênica. Este trabalho relata um caso clínico de ceratoconjuntivite seca iatrogênica, em um cão da raça Boston Terrier de 10 meses de idade, causada pela remoção cirúrgica da glândula lacrimal da terceira pálpebra, quando esta encontrava-se prolapsada.

  15. <em>Angiostrongylus vasorumem> in red foxes (<em>Vulpes vulpesem> and badgers (<em>Meles melesem> from Central and Northern Italy

    Directory of Open Access Journals (Sweden)

    Marta Magi

    2010-06-01

    Full Text Available Abstract During 2004-2005 and 2007-2008, 189 foxes (<em>Vulpes vulpesem> and 6 badgers (<em>Meles melesem> were collected in different areas of Central Northern Italy (Piedmont, Liguria and Tuscany and examined for <em>Angiostrongylus vasorumem> infection. The prevalence of the infection was significantly different in the areas considered, with the highest values in the district of Imperia (80%, Liguria and in Montezemolo (70%, southern Piedmont; the prevalence in Tuscany was 7%. One badger collected in the area of Imperia turned out to be infected, representing the first report of the parasite in this species in Italy. Further studies are needed to evaluate the role played by fox populations as reservoirs of infection and the probability of its spreading to domestic dogs.
    Riassunto <em>Angiostrongylus vasorumem> nella volpe (<em>Vulpes vulpesem> e nel tasso (<em>Meles melesem> in Italia centro-settentrionale. Nel 2004-2005 e 2007-2008, 189 volpi (<em>Vulpes vulpesem> e 6 tassi (<em>Meles melesem> provenienti da differenti aree dell'Italia settentrionale e centrale (Piemonte, Liguria Toscana, sono stati esaminati per la ricerca di <em>Angiostrongylus vasorumem>. La prevalenza del nematode è risultata significativamente diversa nelle varie zone, con valori elevati nelle zone di Imperia (80% e di Montezemolo (70%, provincia di Cuneo; la prevalenza in Toscana è risultata del 7%. Un tasso proveniente dall'area di Imperia è risultato positivo per A. vasorum; questa è la prima segnalazione del parassita in tale specie in Italia. Ulteriori studi sono necessari per valutare il potenziale della volpe come serbatoio e la possibilità di diffusione della parassitosi ai cani domestici.

    doi:10.4404/hystrix-20.2-4442

  16. Is EM dead?

    Science.gov (United States)

    Knott, Graham; Genoud, Christel

    2013-10-15

    Since electron microscopy (EM) first appeared in the 1930s, it has held centre stage as the primary tool for the exploration of biological structure. Yet, with the recent developments of light microscopy techniques that overcome the limitations imposed by the diffraction boundary, the question arises as to whether the importance of EM in on the wane. This Commentary describes some of the pioneering studies that have shaped our understanding of cell structure. These include the development of cryo-EM techniques that have given researchers the ability to capture images of native structures and at the molecular level. It also describes how a number of recent developments significantly increase the ability of EM to visualise biological systems across a range of length scales, and in 3D, ensuring that EM will remain at the forefront of biology research for the foreseeable future.

  17. Modelagem da retenção de herbicidas em zonas ripárias Modeling of herbicide retention in riparian zones

    Directory of Open Access Journals (Sweden)

    Alexandra P. de Pinho

    2006-12-01

    Full Text Available O presente trabalho teve como objetivo investigar a retenção de atrazina e picloram, transportados via escoamento superficial, em zona ripária. Para isto, simulou-se um escoamento superficial, contendo uma mistura de caulinita, atrazina e picloram, dentro de zonas ripárias estabelecidas ao longo de plantações de pinheiros do Nordeste do Estado da Geórgia, EUA. Cinco parcelas foram instaladas dentro de zonas ripárias, apresentando declividades diferentes (2, 5, 10, 15 e 20%. Os efeitos da umidade do solo e da presença do horizonte O na retenção dos dois herbicidas foram avaliados. Um modelo exponencial, comumente utilizado na estimativa de redução da DBO e de nutrientes em tratamento por escoamento superficial, foi empregado na estimativa de redução de herbicidas e caulinita em zonas ripárias. O modelo possibilitou estimar com razoável precisão, a remoção de caulinita e atrazina da mistura em escoamento ao longo de zonas ripárias de 10 m de comprimento. Em geral, a declividade foi o parâmetro que apresentou melhor correlação com a retenção dos contaminantes presentes na mistura em escoamento na zona ripária. O horizonte O, mais espesso nas maiores declividades, favoreceu tanto a sedimentação da caulinita como a adsorção da atrazina.This work aimed to investigate the retention of atrazine and picloram, carried by surface flow, in riparian zones. The surface flow, containing a mixture of both herbicides and kaolin, was then simulated within riparian zones established in pine plantations in north-eastern Georgia, USA. Five plots were established within riparian zones, each with a different slope (2, 5, 10, 15 and 20%. The influence of the initial moisture and of the O horizon condition in herbicide retention was analyzed. An exponential model, commonly used for the estimate of biochemical demand of oxygen (BOD and nutrients attenuation in overland flow treatment, was used to estimate the attenuation of kaolin and

  18. Relationship of lead in drinking water to bone lead levels twenty years later in Boston men: the Normative Aging Study.

    Science.gov (United States)

    Potula, V; Serrano, J; Sparrow, D; Hu, H

    1999-05-01

    Tap water in a city like Boston, which has old houses containing lead plumbing, is known to be a significant source of potential lead exposure. Bone lead levels integrate exposure over many years, and in vivo bone lead measurements have recently become possible with the advent of K x-ray fluorescence instruments. Thus we examined the relationship between first morning tap-water lead levels measured in homes in the 1970s and levels of lead in bone measured in the 1990s among middle-aged to elderly men who lived in those homes. We studied 129 participants in the Normative Aging Study who had lead measured in their homes' tap water in 1976 and 1977 by graphite furnace-atomic absorption spectrophotometry. From 1991 to 1995, the same subjects had blood lead levels measured by graphite furnace-atomic absorption spectroscopy and tibia and patella bone lead levels measured by K x-ray fluorescence. We ran multivariate linear regression models predicting bone lead levels that adjusted for factors which had previously been linked with this outcome in the Normative Aging Study (age, pack-years of smoking, and educational level). Among subjects who lived in houses with > or = 50 micrograms lead/liter of first morning tap water representing water that had been standing overnight in the plumbing in 1976 and 1977, those who reported medium or high levels of tap-water ingestion (> or = 1 glass/day) had progressively higher patella lead levels than did those with low levels of ingestion (glass/day). No such relationship was found among subjects who lived in houses with water in 1976 and 1977. We conclude that ingestion of lead-contaminated tap water is an important predictor of elevated bone lead levels later in life.

  19. A Danish adaptation of the Boston Naming Test: preliminary norms for older adults and validity in mild Alzheimer's disease.

    Science.gov (United States)

    Jørgensen, Kasper; Johannsen, Peter; Vogel, Asmus

    2017-08-30

    The purpose of the present study was to develop a Danish adaptation of the Boston Naming Test (BNT) including a shortened 30-item version of the BNT for routine clinical use and two parallel 15-item versions for screening purposes. The Danish adaptation of the BNT was based on ranking of items according to difficulty in a sample of older non-patients (n = 99). By selecting those items with the largest discrepancy in difficulty for non-patients compared to a mild Alzheimer's disease (AD) sample (n = 53), the shortened versions of the BNT were developed. Using an overlapping cells approach preliminary education and age norms for older Danes were constructed. The Danish adaptation of the BNT had adequate reliability and the short versions were all highly correlated with the full 60-item BNT (BNT-60). The sensitivity and specificity of the BNT-60 was .83 and .86, respectively. The shortened versions displayed some reduction in sensitivity (.70-.77) but similar or better specificity (.86-.91). Post-test probabilities of mild AD associated with performances along selected score ranges of the BNT were estimated. Likelihood ratios were presented that can be combined with information regarding the base rate of AD in any setting in order to assist in interpreting the clinical significance of a given performance. The short Danish versions of the BNT were highly correlated with the full BNT indicating that they measure the same construct. The Danish versions had acceptable diagnostic accuracy discriminating between mild AD and older non-patients.

  20. Fungal Infections Following Boston Type 1 Keratoprosthesis Implantation: Literature Review and In Vitro Antifungal Activity of Hypochlorous Acid

    Science.gov (United States)

    Odorcic, Silvia; Haas, Wolfgang; Gilmore, Michael S.; Dohlman, Claes H.

    2015-01-01

    Purpose To review the current literature describing cases of fungal keratitis and endophthalmitis following Boston Keratoprosthesis (KPro) implantation, and characterize the antifungal activity of 0.01% hypochlorous acid against medically relevant fungi. Methods A literature review of fungal keratitis or endophthalmitis in KPro patients from January 2001 to April 2015, and an in vitro time kill assay characterizing the fungicidal activity of 0.01% hypochlorous acid against fungi causing ocular infections. Results Fifteen publications, predominantly retrospective case series, were identified. Infection rates following KPro implantation ranged from 0.009–0.02 fungal infections per patient-year of follow-up. The largest single surgeon series reported an incidence of 2.4% for fungal endophthalmitis during a 10-year period. Causative organisms included both yeasts and molds. Outcomes were favorable if infections were caught early and treated appropriately; less favorable outcomes were reported in developing countries where fungal species are endemic and resources limited. 0.01% hypochlorous acid is rapidly fungicidal, reducing the number of viable yeast cells or mold conidia by at least 99.99% within 60 seconds. The antifungal activity extended to all molds (Acremonium kiliense, Aspergillus flavus, Aspergillus fumigatus, Fusarium solani, Mucor indicus) and yeast species (Candida albicans, Candida parapsilosis) tested. Conclusions Fungal infections remain a lifelong concern in patients following KPro implantation. There is a growing need for a standard antifungal prophylaxis regimen, especially in the developing world. The rapid broad-spectrum in vitro fungicidal activity of 0.01% hypochlorous acid against all fungi tested makes it an attractive candidate as an antifungal prophylaxis in KPro patients. PMID:26488624

  1. Identifying Sources of Children’s Consumption of Junk Food in Boston After-School Programs, April–May 2011

    Science.gov (United States)

    Austin, S. Bryn; Cradock, Angie L.; Giles, Catherine M.; Lee, Rebekka M.; Davison, Kirsten K.; Gortmaker, Steven L.

    2014-01-01

    Introduction Little is known about how the nutrition environment in after-school settings may affect children’s dietary intake. We measured the nutritional quality of after-school snacks provided by programs participating in the National School Lunch Program or the Child and Adult Care Food Program and compared them with snacks brought from home or purchased elsewhere (nonprogram snacks). We quantified the effect of nonprogram snacks on the dietary intake of children who also received program-provided snacks during after-school time. Our study objective was to determine how different sources of snacks affect children’s snack consumption in after-school settings. Methods We recorded snacks served to and brought in by 298 children in 18 after-school programs in Boston, Massachusetts, on 5 program days in April and May 2011. We measured children’s snack consumption on 2 program days using a validated observation protocol. We then calculated within-child change-in-change models to estimate the effect of nonprogram snacks on children’s dietary intake after school. Results Nonprogram snacks contained more sugary beverages and candy than program-provided snacks. Having a nonprogram snack was associated with significantly higher consumption of total calories (+114.7 kcal, P desserts (+0.3 servings, P < .001), and foods with added sugars (+0.5 servings; P < .001) during the snack period. Conclusion On days when children brought their own after-school snack, they consumed more salty and sugary foods and nearly twice as many calories than on days when they consumed only program-provided snacks. Policy strategies limiting nonprogram snacks or setting nutritional standards for them in after-school settings should be explored further as a way to promote child health. PMID:25412028

  2. Biogeographic ancestry is associated with higher total body adiposity among African-American females: the Boston Area Community Health Survey.

    Directory of Open Access Journals (Sweden)

    Sunali D Goonesekera

    Full Text Available The prevalence of obesity is disproportionately higher among African-Americans and Hispanics as compared to whites. We investigated the role of biogeographic ancestry (BGA on adiposity and changes in adiposity in the Boston Area Community Health Survey.We evaluated associations between BGA, assessed via Ancestry Informative Markers, and adiposity (body mass index (BMI, percent body fat (PBF, and waist-to-hip ratio (WHR and changes in adiposity over 7 years for BMI and WHR and 2.5 years for PBF, per 10% greater proportion of BGA using multivariable linear regression. We also examined effect-modification by demographic and socio-behavioral variables.We observed positive associations between West-African ancestry and cross-sectional BMI (percent difference=0.62%; 95% CI: 0.04%, 1.20%, and PBF (β=0.35; 95% CI: 0.11, 0.58. We also observed significant effect-modification of the association between West-African ancestry and BMI by gender (p-interaction: <0.002 with a substantially greater association in women. We observed no main associations between Native-American ancestry and adiposity but observed significant effect-modification of the association with BMI by diet (p-interaction: <0.003 with inverse associations among participants with higher Healthy Eating Scores. No associations were observed between BGA and changes in adiposity over time.Findings support that West-African ancestry may contribute to high prevalence of total body adiposity among African-Americans, particularly African-American women.

  3. Lung function, asthma symptoms, and quality of life for children in public housing in Boston: a case-series analysis

    Directory of Open Access Journals (Sweden)

    Steinbach Suzanne

    2004-12-01

    Full Text Available Abstract Background Children in urban public housing are at high risk for asthma, given elevated environmental and social exposures and suboptimal medical care. For a multifactorial disease like asthma, design of intervention studies can be influenced by the relative prevalence of key risk factors. To better understand risk factors for asthma morbidity in the context of an environmental intervention study, we conducted a detailed baseline evaluation of 78 children (aged 4–17 years from three public housing developments in Boston. Methods Asthmatic children and their caregivers were recruited between April 2002 and January 2003. We conducted intake interviews that captured a detailed family and medical history, including questions regarding asthma symptom severity, access to health care, medication usage, and psychological stress. Quality of life was evaluated for both the child and caregiver with an asthma-specific scale. Pulmonary function was measured with a portable spirometer, and allergy testing for common indoor and outdoor allergens was conducted with skin testing using the prick puncture method. Exploratory linear and logistic regression models evaluating predictors of respiratory symptoms, quality of life, and pulmonary function were conducted using SAS. Results We found high rates of obesity (56% and allergies to indoor contaminants such as cockroaches (59% and dust mites (59%. Only 36% of children with persistent asthma reported being prescribed any daily controller medication, and most did not have an asthma action plan or a peak flow meter. One-time lung function measures were poorly correlated with respiratory symptoms or quality of life, which were significantly correlated with each other. In multivariate regression models, household size, body mass index, and environmental tobacco smoke exposure were positively associated with respiratory symptom severity (p Conclusion Given the elevated prevalence of multiple risk factors

  4. Collagen cross-linking of the Boston keratoprosthesis donor carrier to prevent corneal melting in high-risk patients.

    Science.gov (United States)

    Robert, Marie-Claude; Arafat, Samer N; Ciolino, Joseph B

    2014-11-01

    To examine the clinical relevance and pathophysiology of Boston keratoprosthesis (B-KPro)-related corneal keratolysis (cornea melt) and to describe a novel method of preventing corneal melt using ex vivo crosslinked cornea tissue carrier. A review of B-KPro literature was performed to highlight cases of corneal melt. Studies examining the effect of corneal collagen cross-linking (CXL) on the biomechanical properties of corneal tissue are summarized. The use of crosslinked corneal tissue as a carrier to the B-KPro is illustrated with a case. Corneal melting after B-KPro is a relatively rare event, occurring in 3% of eyes during the first 3 years of postoperative follow-up. The risk of post-KPro corneal melting is heightened in eyes with chronic ocular surface inflammation such as eyes with Stevens-Johnson syndrome and mucous membrane pemphigoid. This chronic inflammation results in high tear levels of matrix metalloproteinases, the enzymes responsible for collagenolysis and corneal melt. Crosslinked corneal tissue has been shown to have stiffer biomechanical properties and to be more resistant to degradation by collagenolytic enzymes. We have previously optimized the technique for ex vivo corneal CXL and are currently studying its impact on the prevention of corneal melting after B-KPro surgery in high-risk eyes. Crosslinked carrier tissue was used in a 52-year-old man with familial aniridia and severe post-KPro corneal melt. The patient maintained his visual acuity and showed no evidence of corneal thinning or melt in the first postoperative year. Collagen crosslinking was previously shown to halt the enzymatic degradation of corneal buttons ex vivo. This study demonstrates the safety and potential benefit of using crosslinked corneal grafts as carriers for the B-KPro, especially in eyes at higher risk of postoperative melt.

  5. Factors Associated with Hallux Valgus in a Population-Based Study of Older Women and Men: the MOBILIZE Boston Study

    Science.gov (United States)

    Nguyen, Uyen-Sa D.T.; Hillstrom, Howard J.; Li, Wenjun; Dufour, Alyssa B.; Kiel, Douglas P.; Procter-Gray, Elizabeth; Gagnon, Margaret M.; Hannan, Marian T.

    2009-01-01

    Objective To examine potential risk factors for hallux valgus in community-dwelling elders. Method Data from 600 MOBILIZE Boston Study participants (386 women and 214 men) were analyzed. Hallux valgus was defined as > 15 degrees angular deviation of the hallux with respect to the first metatarsal bone toward the lesser toes. Associations of hallux valgus with age, body mass index (BMI), race, education, pes planus, foot pain, and in women, history of high heel shoe use, were assessed using sex-specific Poisson regression with robust variance estimation for risk ratios (RR) and 95% confidence intervals (CI). Results Hallux valgus was present in 58% of women and 25% of men. Higher BMI was inversely associated with presence of hallux valgus in women (p trend = 0.001), with the strongest inverse association observed in those with BMI of 30.0 or more compared to those with normal BMI (RR=0.7, 95% CI: 0.5, 0.9). Women, who usually wore high-heeled shoes during ages 20 to 64 years compared to those who did not, had increased likelihood of hallux valgus (RR=1.2, 95% CI: 1.0, 1.5). Among men, those with BMI between 25.0 and 29.9 had increased likelihood of hallux valgus compared to those with normal BMI (RR=1.9, 95% CI: 1.0, 3.5). Men with pes planus were more likely to have hallux valgus (RR=2.1, 95% CI: 1.3, 3.3) compared to men without pes planus. Conclusion In women, hallux valgus was associated with lower BMI and high heel use during ages 20 to 64, while in men, associations were observed with higher BMI and pes planus. Our results suggest that the etiologic mechanisms for hallux valgus may differ between men and women. PMID:19747997

  6. Beyond anal sex: sexual practices associated with HIV risk reduction among men who have sex with men in Boston, Massachusetts.

    Science.gov (United States)

    Reisner, Sari L; Mimiaga, Matthew J; Skeer, Margie; Mayer, Kenneth H

    2009-07-01

    Men who have sex with men (MSM) continue to bear a disproportionate HIV and sexually transmitted disease (STD) burden. The current study examined the frequency and associations of sexual risk reduction behaviors among a sample of MSM in the greater Boston, Massachusetts area. One hundred eighty-nine MSM completed a one-time behavioral and psychosocial assessment between March 2006 and May 2007. Logistic regression procedures examined the association of demographic, psychosocial, and behavioral factors with risk reduction practices. Twenty percent of the sample reported rimming, mutual masturbation, digital penetration, using sex toys, or 100% condom use as a means to reduce their risk of acquiring or transmitting HIV in the prior 12 months. In bivariate analyses, risk reducers were more likely to disclose their MSM status (i.e., be "out"; odds ratio [OR] = 3.64; p < 0.05), and report oral sex with a condom in the prior 12 months (OR = 4.85; p < 0.01). They were less likely to report: depression (Center for Epidemiologic Studies Depression Scale [CES-D] score 16+; OR = 0.48; p < 0.05), a history of one or more sexually transmitted diseases (STDs; OR = 0.40; p < 0.05), and meeting sexual partners at public cruising areas (OR = 0.32; p < 0.01). In a multivariable model, risk reducers were less likely to report: alcohol use during sex (adjusted odds ratio [AOR] = 0.33; p < 0.05), depression (CESD score 16+; AOR = 0.32; p < 0.05), or meeting sexual partners at public cruising areas (AOR = 0.30; p < 0.05), or via the Internet (AOR = 0.12; p < 0.05) in the previous 12 months. Identifying and understanding such factors associated with risk reduction behaviors may be important to consider in designing effective prevention interventions to promote sexual health for MSM.

  7. Leucemia Mielóide Crônica: novas drogas em desenvolvimento Chronic Myeloid Leukemia: development of new drugs

    Directory of Open Access Journals (Sweden)

    Cármino A. de Souza

    2008-04-01

    Full Text Available A LMC é um modelo de investigação biológica e clinica que deve ser seguido nesta nova fase da oncologia moderna. A resposta terapêutica ao uso do imatinibe como droga de primeira linha mudou os conceitos e paradigmas e criou uma expectativa que drogas mais potentes possam ser desenvolvidas no futuro. Infelizmente nem todos conseguem atingir essa situação ideal. Por esta razão, Baccarani M sugeriu que a falência de resposta subótima, precaução ou alerta fossem estudadas no sentido de serem desenvolvidas intervenções terapêuticas diferenciadas mais precoces. A resistência ao imatinibe existe e depende de vários mecanismos. Tanto mais tardia a introdução do imatinibe e mais avançada for a fase evolutiva da doença maior a freqüência de resistência. Do ponto de vista biológico, a superexpressão do BCR-ABL, os defeitos genéticos adicionais e as mutações que podem atingir várias regiões da molécula - a alça de fosfato, a alça de ativação, o domínio da quinase são os mais importantes fatores associados à resistência ao imatinibe. Por esta razão, são necessárias outras opções terapêuticas e hoje há o desenvolvimento de um grande número de drogas para um número maior de alvos. Inicialmente temos o dasatinibe, já aprovado nos EUA, na Europa e também no Brasil; o nilotinibe, em fase avançada de estudos clínicos (inclusive de fase III, e também já aprovado para uso nos EUA; o bosutinibe, o INNO - 406 bem como outras drogas que atuam em alvos como as aurora-quinases ou inibidores de histona-deacetilases.Chronic Myeloid Leukemia (CML is a model of clinical and biological investigation that may be useful for other neoplastic diseases. The therapeutic response to imatinib as the front line therapy has changed concepts and procedures in CML and has created hope concerning new more potent drugs for this and other oncological diseases that have a similar mechanism of action. However, not all patients achieve

  8. CRESCIMENTO DA ALFACE EM TÚNEIS BAIXOS COM FILME DE POLIETILENO PERFURADO

    Directory of Open Access Journals (Sweden)

    Nereu Augusto Streck

    1994-01-01

    Full Text Available RESUMO Determinou-se o efeito do filme de polietileno perfurado, em túneis baixos, sobre o crescimento da alface em Santa Maria, RS. Os tratamentos, realizados em canteiros de 1,00m x 12,00m x 0,10m, constituiram-se de túneis baixos cobertos com polietileno de baixa densidade e transparente com 0,78% (T1, 1,57% (T2, 2,35% (T3 e 3,14% (T4 de área perfurada e a testemunha sem túnel (T. Utilizou-se a cultivar de alface White Boston, grupo "Lisa", no período de inverno (23.05.91 a 08.08.91 e a cultivar Hampson, grupo "Crespa", no período de primavera (30.08.91 a 30.10.91. Foram feitas determinações da massa da matéria seca do caule e das folhas, área foliar, número de folhas e comprimento do caule. O tratamento que proporcionou maior crescimento das plantas de alface foi o T1 no período invernal e o T3 no período primaveril.

  9. Evaluación de aislamientos de <em>Trichoderma spp.em> contra <em>Rhizoctonia solani em>y <em>Sclerotium rolfsiiem> bajo condiciones<em> in vitro em>y de invernadero

    Directory of Open Access Journals (Sweden)

    Hoyos-Carvajal Liliana

    2008-12-01

    Full Text Available

    Se evaluó la eficacia biológica de ocho aislamientos de <em>Trichoderma spp. em> provenientes de suelos de Colombia para el control de los agentes causales de volcamiento, <em> Sclerotium rolfsiiem> y <em> Rhizoctonia solaniem>, bajo condiciones <em> in vitroem> y de invernadero. Los análisis <em> in vitroem> mostraron la capacidad antagónica de todos los aislamientos evaluados. En condiciones de invernadero, cuatro aislamientos fueron altamente eficaces contra <em> S. rolfsiiem> en plantas de fríjol en semillero (>90% de reducción de la enfermedad y dos aislamientos fueron eficaces contra <em> R. solaniem> en plantas de algodón en semillero (58 y 61% de reducción de la enfermedad. El análisis UP-PCR y DS-PCR permitió determinar tres grupos de aislamientos; dentro de estas asociaciones formadas no se encontró ninguna relación evidente entre la posición en el dendrograma y la actividad antagónica, pero sí permitió separar las especies de <em> Trichodermaem> por grupos, e incluso encontrar diferencias dentro de aislamientos de una misma especie. Los resultados muestran que el comportamiento micoparasítico de los aislamientos de <em> Trichoderma spp. em> varía según el hongo fitopatógeno, evidenciando una amplia especificidad del antagonista por su sustrato, es decir por el hongo atacado; por lo tanto es necesario realizar cuidadosas selecciones del aislamiento de <em> Trichodermaem> que se utilice en programas de control de fitopatógenos.

  10. Expression of Selected <em>Ginkgo em>>biloba em>Heat Shock Protein Genes After Cold Treatment Could Be Induced by Other Abiotic Stress

    Directory of Open Access Journals (Sweden)

    Feng Xu

    2012-05-01

    Full Text Available Heat shock proteins (HSPs play various stress-protective roles in plants. In this study, three <em>HSP> genes were isolated from a suppression subtractive hybridization (SSH cDNA library of <em>Ginkgo bilobaem> leaves treated with cold stress. Based on the molecular weight, the three genes were designated <em>GbHSP16.8em>, <em>GbHSP17em> and <em>GbHSP70em>. The full length of the three genes were predicted to encode three polypeptide chains containing 149 amino acids (Aa, 152 Aa, and 657 Aa, and their corresponding molecular weights were predicted as follows: 16.67 kDa, 17.39 kDa, and 71.81 kDa respectively. The three genes exhibited distinctive expression patterns in different organs or development stages. <em>GbHSP16.8em> and <em>GbHSP70em> showed high expression levels in leaves and a low level in gynoecia, <em>GbHSP17em> showed a higher transcription in stamens and lower level in fruit. This result indicates that <em>GbHSP16.8em> and <em>GbHSP70 em>may play important roles in <em>Ginkgo> leaf development and photosynthesis, and <em>GbHSP17em> may play a positive role in pollen maturation. All three <em>GbHSPs> were up-regulated under cold stress, whereas extreme heat stress only caused up-regulation of <em>GbHSP70em>, UV-B treatment resulted in up-regulation of <em>GbHSP16.8em> and <em>GbHSP17em>, wounding treatment resulted in up-regulation of <em>GbHSP16.8em> and <em>GbHSP70em>, and abscisic acid (ABA treatment caused up-regulation of <em>GbHSP70em> primarily.

  11. Erro médico em pacientes hospitalizados Medical errors in hospitalized patients

    Directory of Open Access Journals (Sweden)

    Manoel de Carvalho

    2002-01-01

    Full Text Available Objetivo: o presente artigo tem por objetivo revisar a literatura e discutir a questão do erro médico em pacientes hospitalizados, enfocando sua conceituação, incidência, fatores predisponentes e mecanismos de prevenção. Aborda, em especial, erros e eventos adversos com drogas envolvendo recém-nascidos e pacientes pediátricos. Métodos: revisão bibliográfica utilizando banco de dados Medline, selecionando-se aqueles com informações atuais e relevantes. Resultados:mesmo assumindo que a notificação do erro médico não ocorre em um grande número de eventos, é importante notar que sua incidência é muito maior do que julgamos. Só nos EUA, cerca de um milhão de pacientes por ano são vítimas de erros médicos e eventos adversos com drogas. Segundo recente metanálise, esta é, hoje, a quarta causa de morte nos EUA. Em unidades de terapia intensiva neonatal e pediátrica, nas quais é grande a complexidade e a freqüência de procedimentos, a ocorrência de erros é maior. Estima-se que quinze por cento das internações em unidades de terapia intensiva neonatal sejam acompanhadas de erro médico. A maioria destes erros acontece durante o período noturno, e envolve administração incorreta de droga (35% e erro na interpretação da prescrição (26%. Fatores ambientais (barulho, calor, psicológicos (tédio, ansiedade, estresse e fisiológicos (fadiga, sono contribuem para a ocorrência de erros. Recente estudo revela que após um plantão de 24 horas, sem dormir, o desempenho psicomotor de um profissional de saúde é semelhante ao de um indivíduo legalmente bêbado (nível sérico alcoólico maior ou igual a 0,08%! Conclusões: mesmo em profissionais conscientes, erros são acompanhantes inevitáveis da condição humana. A prevenção de erros deve basear-se na busca de causas reais, que geralmente incluem erros no sistema de organização e implementação do serviço. Erros devem ser aceitos como evidência de falha no

  12. Cuba após a Guerra Fria: mudanças econômicas, nova agenda diplomática e o limitado diálogo com os EUA Cuba after the Cold War: economic change, new diplomatic agenda and the limited dialogue with the United States

    Directory of Open Access Journals (Sweden)

    Maurício Santoro

    2010-07-01

    Full Text Available Cuba passou por muitas transformações após a Guerra Fria. A economia está mais diversificada e o país logrou escapar do isolamento internacional, estabelecendo parcerias com China, União Européia e América Latina. Além disso, a transformação na comunidade cubano-americana coloca em posições de influência ativistas mais jovens, com maior disposição para o diálogo com os Estados Unidos, inclusive em temas comerciais. Contudo, é difícil que as negociações avancem em pontos controversos, pela relutância de Havana em liberalizar o regime político.Cuba has undergone several transformations after the Cold War. The economy has become more diversified and the country has been able to overcome international isolation, and in so doing establish partnerships with China, the European Union and Latin America. In addition, the changes in the Cuban-American community have put younger activists who are more willing to enter into dialogue with the United States, on such matters for example as foreign trade. However, it is difficult for the negotiations to solve more controversial points because of the continued reluctance of Havana to liberalize the political regime.

  13. COMPARISON OF VISUAL AND ANATOMICAL OUTCOMES OF EYES UNDERGOING TYPE I BOSTON KERATOPROSTHESIS WITH COMBINATION PARS PLANA VITRECTOMY WITH EYES WITHOUT COMBINATION VITRECTOMY.

    Science.gov (United States)

    Lim, Jennifer I; Machen, Lindsay; Arteaga, Andrea; Karas, Faris I; Hyde, Robert; Cao, Dingcai; Niec, Marcia; Vajaranant, Thasarat S; Cortina, M Soledad

    2018-01-23

    To determine whether 1-year visual and anatomical results after surgery combining pars plana vitrectomy, Boston keratoprosthesis, and a glaucoma drainage device as needed are similar, better, or worse than Boston keratoprosthesis initial implantation alone. We performed a retrospective review of adult patients undergoing Boston keratoprosthesis at our institution. Visual acuity outcomes, anatomical results, and complication rates of patients undergoing combination surgery (including pars plana vitrectomy and a posterior glaucoma drainage device) were compared with those undergoing keratoprosthesis placement alone. There were 70 eyes in the keratoprosthesis alone group and 55 eyes in the keratoprosthesis with pars plana vitrectomy group. Mean follow-up durations were 54.67 months in the keratoprosthesis alone group and 48.41 months in the combination group. Baseline mean Snellen equivalent visual acuities were worse for the combination group compared with the keratoprosthesis alone group (P = 0.027). Visual acuities improved postoperatively by 1 month after keratoprosthesis implantation for both groups and improved three or more lines of Snellen acuity in the majority of eyes for both groups (≥72% by 12 months). Eyes undergoing pars plana vitrectomy had lower rates of de novo (P = 0.015) and significantly lower rates of secondary procedures (P = 0.002) at 1 year. One year complications rates for retroprosthetic membrane formation, retinal detachment, hypotony, cystoid macular edema, epiretinal membrane formation, endophthalmitis, and corneal melting were similar for both groups. Compared with keratoprosthesis alone, combining keratoprosthesis with pars plana vitrectomy and a glaucoma drainage device as needed, resulted in lower rates of de novo glaucoma, lower rates of additional surgical procedures, similar visual acuity outcomes at 1 year, and did not result in higher complication rates.

  14. Ocular blast injuries in mass-casualty incidents: the marathon bombing in Boston, Massachusetts, and the fertilizer plant explosion in West, Texas.

    Science.gov (United States)

    Yonekawa, Yoshihiro; Hacker, Henry D; Lehman, Roy E; Beal, Casey J; Veldman, Peter B; Vyas, Neil M; Shah, Ankoor S; Wu, David; Eliott, Dean; Gardiner, Matthew F; Kuperwaser, Mark C; Rosa, Robert H; Ramsey, Jean E; Miller, Joan W; Mazzoli, Robert A; Lawrence, Mary G; Arroyo, Jorge G

    2014-09-01

    To report the ocular injuries sustained by survivors of the April 15, 2013, Boston Marathon bombing and the April 17, 2013, fertilizer plant explosion in West, Texas. Multicenter, cross-sectional, retrospective, comparative case series. Seventy-two eyes of 36 patients treated at 12 institutions were included in the study. Ocular and systemic trauma data were collected from medical records. Types and severity of ocular and systemic trauma and associations with mechanisms of injury. In the Boston cohort, 164 of 264 casualties were transported to level 1 trauma centers, and 22 (13.4%) required ophthalmology consultations. In the West cohort, 218 of 263 total casualties were transported to participating centers, of which 14 (6.4%) required ophthalmology consultations. Boston had significantly shorter mean distances to treating facilities (1.6 miles vs. 53.6 miles; P = 0.004). Overall, rigid eye shields were more likely not to have been provided than to have been provided on the scene (PBoston sustained more lower extremity injuries because of the ground-level bomb. Overall, 27.8% of consultations were called from emergency rooms, whereas the rest occurred afterward. Challenges in logistics and communications were identified. Ocular injuries are common and potentially blinding in mass-casualty incidents. Systemic and ocular polytrauma is the rule in terrorism, whereas isolated ocular injuries are more common in other calamities. Key lessons learned included educating the public to stay away from windows during disasters, promoting use of rigid eye shields by first responders, the importance of reliable communications, deepening the ophthalmology call algorithm, the significance of visual incapacitation resulting from loss of spectacles, improving the rate of early detection of ocular injuries in emergency departments, and integrating ophthalmology services into trauma teams as well as maintaining a voice in hospital-wide and community-based disaster planning. Copyright

  15. La retórica de Obama ante el terrorismo: estudio del uso de la red social Twitter tras los atentados de Boston de abril de 2013

    OpenAIRE

    Franch, Pere

    2013-01-01

    El presente trabajo estudia dos aspectos de la retórica del presidente norteamericano, Barack Obama, tras los atentados de Boston de abril de 2013: el contenido de sus discursos orales y el uso que hizo de su cuenta en la red social Twitter después de los atentados. La investigación, basada en el análisis de contenido textual de los discursos y de los tuits publicados, ha permitido constatar tres hechos: Primero, que en las intervenciones públicas de Obama se mantienen las p...

  16. Mapping carbon storage in urban trees with multi-source remote sensing data: relationships between biomass, land use, and demographics in Boston neighborhoods.

    Science.gov (United States)

    Raciti, Steve M; Hutyra, Lucy R; Newell, Jared D

    2014-12-01

    High resolution maps of urban vegetation and biomass are powerful tools for policy-makers and community groups seeking to reduce rates of urban runoff, moderate urban heat island effects, and mitigate the effects of greenhouse gas emissions. We developed a very high resolution map of urban tree biomass, assessed the scale sensitivities in biomass estimation, compared our results with lower resolution estimates, and explored the demographic relationships in biomass distribution across the City of Boston. We integrated remote sensing data (including LiDAR-based tree height estimates) and field-based observations to map canopy cover and aboveground tree carbon storage at ~1m spatial scale. Mean tree canopy cover was estimated to be 25.5±1.5% and carbon storage was 355Gg (28.8MgCha(-1)) for the City of Boston. Tree biomass was highest in forest patches (110.7MgCha(-1)), but residential (32.8MgCha(-1)) and developed open (23.5MgCha(-1)) land uses also contained relatively high carbon stocks. In contrast with previous studies, we did not find significant correlations between tree biomass and the demographic characteristics of Boston neighborhoods, including income, education, race, or population density. The proportion of households that rent was negatively correlated with urban tree biomass (R(2)=0.26, p=0.04) and correlated with Priority Planting Index values (R(2)=0.55, p=0.001), potentially reflecting differences in land management among rented and owner-occupied residential properties. We compared our very high resolution biomass map to lower resolution biomass products from other sources and found that those products consistently underestimated biomass within urban areas. This underestimation became more severe as spatial resolution decreased. This research demonstrates that 1) urban areas contain considerable tree carbon stocks; 2) canopy cover and biomass may not be related to the demographic characteristics of Boston neighborhoods; and 3) that recent advances

  17. Characterizing local EMS systems.

    Science.gov (United States)

    2013-08-01

    Emergency medical services (EMS) systems are configured differently depending on several factors, including the size, demographics, geography, and politics of the local communities they serve. Although some information exists about the organization, ...

  18. International EMS Systems

    DEFF Research Database (Denmark)

    Langhelle, Audun; Lossius, Hans Morten; Silfvast, Tom

    2004-01-01

    Emergency medicine service (EMS) systems in the five Nordic countries have more similarities than differences. One similarity is the involvement of anaesthesiologists as pre-hospital physicians and their strong participation for all critically ill and injured patients in-hospital. Discrepancies do...... exist, however, especially within the ground and air ambulance service, and the EMS systems face several challenges. Main problems and challenges emphasized by the authors are: (1) Denmark: the dispatch centres are presently not under medical control and are without a national criteria based system....... Access to on-line medical advice of a physician is not available; (2) Finland: the autonomy of the individual municipalities and their responsibility to cover for primary and specialised health care, as well as the EMS, and the lack of supporting or demanding legislation regarding the EMS; (3) Iceland...

  19. Promover competências em contexto educativo: estudo de três propostas de intervenção = Promote competencies in an educational context: study of three intervention proposals

    Directory of Open Access Journals (Sweden)

    Dias, Maria Isabel Pinto Simões

    2014-01-01

    Full Text Available Este estudo tem como objetivo refletir sobre a promoção de competências em contexto educativo, apresentando três propostas de intervenção psicoeducativa, o Programa G oing for the Goal – GOAL (DANISH, MEYER, MASH, HOWARD, CURL, OWENS e KENDALL, 1992, o Programa de Promoção de Competências Sociais (MATOS, SILVA, ALÃO, ALVES, SAMPAIO e CARVALHO, 1997 e o Programa Instrutivo para a Educação e Libertação Emocional – PIELE (HERNÁNDEZ e HERNANDÉZ, 2001. Visando o desenvolvimento pessoal e social dos seus participantes (crianças e jovens, estes programas recorrem a pequenas peças/histórias, à expressão corporal e à dramatização para o ensino/aprendizagem de competências transversais. Assumindo uma metodologia interventiva contextualizada e ativa, defendem o formador como um facilitador das aprendizagens que centra a sua atenção nos sujeitos aprendentes. Tendo sido implementados em contexto educativo nos EUA e na Europa, os dados da avaliação da sua eficácia revelam ganhos ao nível do desenvolvimento de valores pró- sociais, do bem-estar, da aquisição de comportamentos sociais e da autovalorização. Essas evidências induzem- nos a acreditar que serão propostas de promoção de competências a conhecer e a utilizar em contexto educativo

  20. Retinite por citomegalovírus em pacientes pediátricos infectados pelo vírus da imunodeficiência humana em tratamento com "highly active antiretrovirus therapy" Cytomegalovirus retinitis in pediatric patients with AIDS receiving highly active antiretrovirus therapy

    Directory of Open Access Journals (Sweden)

    Maria Angélica Dimantas

    2004-09-01

    Full Text Available OBJETIVO: Descrever uma série de casos de retinite pelo citomegalovírus (CMV, na população pediátrica infectada pelo vírus da imunodeficiência humana (HIV, em tratamento com inibidores de protease e inibidores da transcriptase reversa (HAART, que apresentaram falência terapêutica e ausência de resposta aos antivirais utilizados no tratamento do CMV. MÉTODOS: Três pacientes pediátricos portadores da síndrome da imunodeficiência humana (AIDS, em tratamento com HAART, foram submetidos a exame oftalmológico em um centro universitário de referência - UNIFESP. RESULTADOS: Os três pacientes do sexo masculino apresentavam média de idade de seis anos (variando entre 10 meses e 13 anos e todos pertenciam à classificação C3 (CDC - Atlanta - EUA 1994. A média obtida entre a contagem de linfócitos CD4+ dos três casos foi de 67 cel/mm³ (variando entre 43 - 98 cel/mm³; e a média da carga viral foi de 190.000 cópias/ml (variando entre 53.600 - 460.000 cópias/ml. Os três pacientes desenvolveram resistência ao uso dos antiretrovirais análogos de nucleosídeos inibidores da transcriptase reversa e aos inibidores de protease (HAART, e em todos os casos foram utilizados antivirais específicos para o tratamento da retinite pelo CMV sem sucesso. CONCLUSÕES: Os benefícios obtidos desde a introdução da era HAART são, sem dúvida, sem precedentes dentro do quadro evolutivo da AIDS. O início da falência terapêutica observado com relação às drogas do HAART tem colaborado de maneira decisiva para o surgimento de casos de retinite pelo CMV tão agressivos quanto os observados na era pré-HAART. O exame de rotina para pacientes pediátricos torna-se fundamental, tanto pela escassez de estudos realizados neste grupo específico, quanto pela importância de seu prognóstico visual.BACKGROUND: To describe three cases of cytomegalovirus retinitis occurring in HIV-infected children taking protease inhibitors combined with transcriptase