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Sample records for elephantiasis nostras verrucosa

  1. Elephantiasis nostras verrucosa: a review.

    Science.gov (United States)

    Sisto, Krisanne; Khachemoune, Amor

    2008-01-01

    Elephantiasis nostras verrucosa (ENV) is a rare and dramatic sequela of chronic nonfilarial lymphedema. The condition is characterized by papules, verrucous lesions, enlargement, and woody fibrosis of the affected area. ENV is a progressive condition, and, without intervention, ongoing deformity and disability will result. Management of ENV is often challenging, but a variety of successful medical and surgical treatment strategies have been reported.

  2. A case of elephantiasis nostras verrucosa treated by acitretin.

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    Polat, Mualla; Sereflican, Betül

    2012-03-01

    Elephantiasis nostras verrucosa is a rare disorder characterized by dermal fibrosis, hyperkeratotic, verrucous, and papillomatous lesions that result from both chronic filarial and nonfilarial lymphedema. Various treatment options have been reported for this disease. We present a 64-year-old man with erythrodermic psoriasis and elephantiasis nostras verrucosa in whom the lesions were resolved almost completely after acitretin treatment.

  3. Elephantiasis nostras verrucosa complicated with chronic tibial osteomyelitis.

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    Turhan, Egemen; Ege, Ahmet; Keser, Selcuk; Bayar, Ahmet

    2008-10-01

    Elephantiasis nostras verrucosa represents an infrequent clinical entity with cutaneous changes characterized by dermal fibrosis, hyperkeratotic verrucous and papillamotous lesions resulting from chronic non-filarial lymphedema secondary to infections, surgeries, tumor obstruction, radiation, congestive heart failure, and obesity. Although recurrent streptococcal lymphangitis is believed to play a critical role in the origin of elephantiasis nostras verrucosa, the exact pathogenesis of the disorder is not yet clear. Therapeutic efforts should aim to reduce lymph stasis, which will also lead to improvement of the cutaneous changes but unfortunately there is no specific treatment for advanced cases. In this report, we present a patient who was treated by below knee amputation as a result of elephantiasis nostras verrucosa complicated with chronic tibial osteomyelitis.

  4. Elephantiasis nostras verrucosa of lower limb: a case report.

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    Kalafi, Amir; Vasaghi, Attiyeh

    2014-01-01

    Elephantiasis nostras verrucosa (ENV) is a rare condition in which hyperkeratosis, fibrosis and disfiguration of dermis occurs. It is caused mostly by non infectious diseases such as surgery, trauma, tumors, and venous obstructions. To our knowledge there is not any case report of ENV in Middle East region. In this patient, ENV caused by trauma and Patient presented with enlargement of right lower limb.

  5. Elephantiasis nostras verrucosa on the abdomen of a Turkish female patient caused by morbid obesity.

    Science.gov (United States)

    Buyuktas, D; Arslan, E; Celik, O; Tasan, E; Demirkesen, C; Gundogdu, S

    2010-08-15

    Elephantiasis Nostras Verrucosa is a rare disorder of an extremity or a body region, which is associated with chronic lymphedema. There are 7 reported cases of abdominal elephantiasis in the medical literature. Here we report a morbidly obese female patient with elephantiasis nostras verrucosa on the abdominal wall.

  6. Successful Surgical Treatment for Elephantiasis Nostras Verrucosa Using a New Designed Column Flap.

    Science.gov (United States)

    Han, Hyun Ho; Lim, Soo Yeon; Oh, Deuk Young

    2015-09-01

    Elephantiasis nostras verrucosa is a chronic lymphedema that causes enlarged and disfigured extremities. There are plenty of treatment options. However, there is no complete treatment. Preventive or symptomatic therapy is the basis for treating elephantiasis. In this article, we report a case of elephantiasis nostras verrucosa treated successfully by surgical reconstruction using a newly designed column flap. © The Author(s) 2015.

  7. [Elephantiasis nostras verrucosa in a patient with major depressive disorder].

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    Simón Llanes, J; Coll Vilar, I; Tamarit Francés, C; Niubó de Castro, I

    2012-01-01

    Elephantiasis nostras verrucosa is a rare condition characterised by papules, verrucous lesions, fibrosis and deformity of the affected area. It is caused by chronic lymphedema that could be congenital or produced by a non-associated infection (such as tuberculosis, mycotic infection, syphilis), surgery, radiotherapy, trauma, neoplastic obstruction, obesity, portal hypertension, or congestive heart failure. There is no standard treatment for this rare skin disorder. Depending on the cause and the severity, the treatment can be medical or surgical. We report the case of a man seen in our hospital with a major depression and elephantiasis nostras verrucosa skin lesions on both legs, who was successfully treated with surgical debridement and conservative measures. Copyright © 2011 Elsevier España, S.L. y SEMERGEN. All rights reserved.

  8. Elephantiasis nostras verrucosa of lower limb: a case report.

    Directory of Open Access Journals (Sweden)

    Amir Kalafi

    2014-10-01

    Full Text Available Elephantiasis nostras verrucosa (ENV is a rare condition in which hyperkeratosis, fibrosis and disfiguration of dermis occurs. It is caused mostly by non infectious diseases such as surgery, trauma, tumors, and venous obstructions. To our knowledge there is not any case report of ENV in Middle East region. In this patient, ENV caused by trauma and Patient presented with enlargement of right lower limb.

  9. Elephantiasis nostras verrucosa on the legs and abdomen with morbid obesity in an Indian lady.

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    Sarma, Podila S; Ghorpade, Ashok

    2008-12-15

    Elephantiasis nostras verrucosa (ENV) of the legs and abdomen in a morbidly obese woman with multiple medical problems is reported. The diagnosis was suggested by the classical clinical features and confirmed by histopathology. The patient succumbed due to her multisystem diseases. Elephantiasis nostras verrucosa involving the abdomen is uncommon and has been reported only five times in the past.

  10. Elephantiasis nostras verrucosa: a rare complication of lower limb lymphoedema.

    Science.gov (United States)

    Kar Keong, Neoh; Siing Ngi, Angelina Tang; Muniandy, Pubalan; Voon Fei, Wong

    2017-08-28

    We reported a case of a 49-year-old man who had chronic lymphoedema of bilateral lower limbs for 30 years, but he did not seek treatment. His disease was complicated with irreversible changes of elephantiasis nostras verrucosa and had recurrent admissions due to infection. He was not keen for surgical intervention. This case report illustrated a rare and non-reversible complication of a common skin disease, lymphoedema and also the importance of identifying and treating it early. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  11. Elephantiasis nostras verrucosa or "mossy foot lesions" in lymphedema praecox: report of a case.

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    Duckworth, Amy L; Husain, Jugnoo; Deheer, Patrick

    2008-01-01

    Elephantiasis nostras verrucosa is a rare disorder that results from chronic obstructive lymphedema. It is characterized clinically by deforming, nonpitting edema; malodorous hyperkeratosis with generalized lichenification; cobblestoned papules; and verrucous changes, that often result in extreme enlargement of the involved body part. Although elephantiasis nostras verrucosa is striking in clinical appearance, biopsy reveals only moderately abnormal findings: pseudoepitheliomatous hyperplasia with dilated lymphatic spaces in the dermis, accompanied by chronic inflammation and fibroblast proliferation. The term elephantiasis nostras (nostras means "from our region") has traditionally been used to differentiate temperate zone disease from the classic disease process, elephantiasis tropica, which is defined by chronic filarial lymphatic obstruction caused by Wuchereria bancrofti, Wuchereria malayi, or Wuchereria pacifica. We present a case report of elephantiasis nostras verrucosa arising as a result of lymphedema praecox.

  12. Elephantiasis nostras verrucosa in a patient with systemic sclerosis.

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    Chatterjee, S; Karai, L J

    2009-12-01

    Elephantiasis nostras verrucosa (ENV) is an unusual skin condition characterized by dermal fibrosis and hyperkeratotic verrucous lesions resulting from chronic nonfilarial lymphoedema. The condition is similar to 'elephantiasis tropica', in which elephantiasis develops secondary to filariasis. Lymphatic obstruction can be primary or due to various causes such as surgery, tumour, radiation, congestive heart failure or obesity. Recurrent attacks of cellulitis lead to further impairment of lymphatic drainage, causing permanent swelling, dermal fibrosis and epidermal thickening. We report a case of a 56-year-old man with systemic sclerosis (SS), who presented with painful lesions on both legs, consistent with ENV. He developed extensive, fungating, papillomatous lesions on the skin of the legs, toes and dorsa of the feet over a period of 3 years. Histology revealed dense dermal fibrosis, oedema of the papillary dermis and extensive pseudo-epitheliomatous changes. To our knowledge, this is the first report of ENV in which SS was considered to be the primary cause for the impairment of lymphatic flow.

  13. Elephantiasis nostras verrucosa: an institutional analysis of 21 cases.

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    Dean, Steven M; Zirwas, Matthew J; Horst, Anthony Vander

    2011-06-01

    Previous reports regarding elephantiasis nostras verrucosa (ENV) have been typically limited to 3 or fewer patients. We sought to statistically ascertain what demographic features and clinical variables are associated with ENV. A retrospective chart review of 21 patients with ENV from 2006 to 2008 was performed and statistically analyzed. All 21 patients were obese (morbid obesity in 91%) with a mean body mass index of 55.8. The average maximal calf circumference was 63.7 cm. Concurrent chronic venous insufficiency was identified in 15 patients (71%). ENV was predominantly bilateral (86%) and typically involved the calves (81%). Proximal cutaneous involvement (thighs 19%/abdomen 9.5%) was less common. Eighteen (86%) related a history of lower extremity cellulitis/lymphangitis and/or manifested soft-tissue infection upon presentation. Multisegmental ENV was statistically more likely in setting of a higher body mass index (P = .02), larger calf circumference (P = .01), multiple lymphedema risk factors (P = .05), ulcerations (P < .001), and nodules (P < .001). Calf circumference was significantly and proportionally linked to developing lower extremity ulcerations (P = .02). Ulcerations and nodules were significantly prone to occur concomitantly (P = .05). Nodules appeared more likely to exist in the presence of a higher body mass index (P = .06) and multiple lymphedema risk factors (P = .06). The statistical conclusions were potentially inhibited by the relatively small cohort. The study was retrospective. Our data confirm the association among obesity, soft-tissue infection, and ENV. Chronic venous insufficiency may be an underappreciated risk factor in the genesis of ENV. Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  14. Elephantiasis Nostras Verrucosa. Excision with full-thickness skin grafting of the penis, scrotum, and perineal area.

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    Judge, Nathan; Kilic, Ali

    2016-11-13

    Elephantiasis nostras verrucosa is a rare cutaneous complication of chronic lymphatic obstruction. It is most commonly caused by bacterial infection, trauma, neoplasia, obesity, and venous stasis. In this report, we describe a case of elephantiasis nostras verrucosa involving the scrotum and perineal area in a 32-year-old. The lesions were excised, and full-thickness skin grafting of the penis, scrotum, and perineal skin was performed. This case demonstrates the efficacy of excision with full-thickness skin grafting of the penis, scrotum, and perineal area in a patient with elephantiasis nostras verrucosa confined to the scrotum and perineal region.

  15. Elephantiasis nostras verrucosa on the buttocks and sacrum of two immobile men.

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    Setyadi, Hedy G; Iacco, Megan Reif; Shwayder, Tor A; Ormsby, Adrian

    2011-02-15

    Though typically involving the lower extremities, elephantiasis nostras verrucosa (ENV) can occur in any area affected by lymphedema. Here we report two cases of ENV: one is a biopsy-proven case and the other is a clinically diagnosed case. Both occurred on the buttocks and sacrum of immobile, morbidly obese men who were persistently in the supine or seated position. Whereas classic ENV is not uncommon, this striking presentation on these unusual areas is quite rare.

  16. The Successful Treatment of Elephantiasis Nostras Verrucosa With Ablative Carbon Dioxide Laser.

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    Robinson, Caitlin G; Lee, Kory R; Thomas, Valencia D

    2018-03-01

    Elephantiasis nostras verrucosa (ENV) is a disfiguring skin condition that is difficult to treat. Existing treatment modalities serve to improve cosmesis or treat symptoms. Herein, we report a case of ENV with lymphocutaneous fistula successfully treated with ablative carbon dioxide laser. A 57-year-old woman with biopsy-proven ENV with lymphocutaneous fistula was treated with ablative carbon dioxide laser to the symptomatic area of her right thigh in 3 treatment sessions over 6 months. The patient had resolution of lymphocutaneous drainage as well as 90% improvement in the appearance of ENV lesions at the 1-month follow-up visit. Ablative carbon dioxide laser may provide cosmetic, symptomatic, and medical benefit for patients with localized ENV.

  17. Dermatologia comparativa: similaridade entre elefantíase nostra verrucosa e coral Comparative dermatology: elephantiasis nostra in verrucous form comparable to coral

    Directory of Open Access Journals (Sweden)

    Lana Bezerra Fernandes

    2011-08-01

    Full Text Available Demonstra-se quadro raro de Elefantíase Nostra, na sua forma verrucosa, no dorso de pé de homem de 80 anos por episódios prévios de erisipela de repetição. As lesões confluentes vegetantes e difusas em dorso de pé são comparáveis aos corais Trumpet Coral (Caulastrea curvataStudy of a rare case of Elephantiasis Nostra in verrucous form on the dorsum of the foot of an 80year-old male with a history of recurrent erysipelas infection. The vegetant, confluent lesions on the foot resemble Trumpet Coral (Caulastrea curvata

  18. Excision of Elephantiasis Nostras Verrucosa Lesions in a Patient With Hereditary Lymphedema: Case Report and Review of the Literature.

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    Pitcher, Austin A; Pagan, Carlos A; Small, Kevin; Otterburn, David M

    2015-01-01

    Elephantiasis nostras verrucosa (ENV) is a rare cutaneous sequela of chronic lymphedema. Treatment of ENV remains poorly elucidated but has historically involved conservative management aimed at relieving the underlying lymphedema, with a few cases managed by surgical intervention. We report a case of a 27-year-old male with primary lymphedema complicated by large painful ENV lesions on his left foot that we excised surgically with good functional and cosmetic results as validated by the patient. To our knowledge, this is the first report of a case of ENV with a pedunculated morphology and the presence of a deep invasive stalk. Copyright © 2015 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

  19. Hypothyroid Graves' disease complicated with elephantiasis nostras verrucosa (ENV): a case report and review of the literature.

    Science.gov (United States)

    Ukinç, Kubilay; Bayraktar, Miyase; Gedik, Arzu

    2009-08-01

    Thyroid dermopathy is not a frequent feature of hyperthyroid Graves' disease, being present in less than 5% of the patients. Graves' disease has been shown to exist in euthyroid or hypothyroid forms in untreated patients. Here, we describe a case of hypothyroid Graves' disease with elephantiasis nostras verrucosa (ENV), which is an extreme form of thyroid dermopathy (TD). A 58-year-old female patient was admitted to the emergency department with somnolence, hypothermia, and bradycardia. Her mental status gradually worsened, resulting in a deep coma. She was intubated and followed in the intensive care unit, as she needed mechanical ventilatory assistance due to respiratory failure. She also had bilateral non-pitting edema, a cobblestone-like appearance, and hyperkeratotic greenish-brown-colored lesions in the pretibial and dorsal regions of the feet that were compatible with ENV. Hypothyroid Graves' disease is a very rare condition among autoimmune thyroid disorders, and ENV is an extremely rare form of TD. Here, we present a patient with hypothyroid Graves' disease and ENV.

  20. Verrucous lesions arising in lymphedema and diabetic neuropathy: Elephantiasis nostras verrucosa or verrucous skin lesions on the feet of patients with diabetic neuropathy?

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    Hotta, Eri; Asai, Jun; Okuzawa, Yasutaro; Hanada, Keiji; Nomiyama, Tomoko; Takenaka, Hideya; Katoh, Norito

    2016-03-01

    Verrucous skin lesions on the feet in diabetic neuropathy (VSLDN) develop in areas with sensory loss in diabetic patients. Although various types of chronic stimulation, such as pressure or friction, are considered an important factor in the development of such lesions, the precise pathogenesis of VSLDN remains obscure, and there is currently no established treatment for this disease. Here, we present a case of VSLDN on the dorsum of the right foot. However, because lymphedema was also observed at the same site, this lesion could also be diagnosed as elephantiasis nostras verrucosa arising in diabetic neuropathy. The lesion was successfully treated with a combination of elastic stocking and mixed killed bacterial suspension and hydrocortisone ointment, which suggested that VSLDN might have been exacerbated by the pre-existing lymphedema. Because various types of chronic stimulation can trigger VSLDN, treatment plans should be devised on a case-by-case basis. Therefore, it is important to investigate the presence of factors that can induce or exacerbate chronic inflammatory stimulation, such as lymphedema in our case, in each patient with VSLDN. © 2015 Japanese Dermatological Association.

  1. Comparative dermatology: elephantiasis nostra in verrucous form comparable to coral.

    Science.gov (United States)

    Fernandes, Lana Bezerra; Fleury Junior, Luiz Fernando Fróes

    2011-01-01

    Study of a rare case of Elephantiasis Nostra in verrucous form on the dorsum of the foot of an 80 year-old male with a history of recurrent erysipelas infection. The vegetant, confluent lesions on the foot resemble Trumpet Coral (Caulastrea curvata).

  2. Debulking surgery for elephantiasis nostras with large ectatic podoplanin-negative lymphatic vessels in patients with lipo-lymphedema.

    Science.gov (United States)

    Wollina, Uwe; Heinig, Birgit; Schönlebe, Jaqueline; Nowak, Andreas

    2014-01-01

    Elephantiasis nostras is a rare complication in advanced lipo-lymphedema. While lipedema can be treated by liposuction and lymphedema by decongestive lymphatic therapy, elephantiasis nostras may need debulking surgery. We present 2 cases of advanced lipo-lymphedema complicated by elephantiasis nostras. After tumescent microcannular laser-assisted liposuction both patients underwent a debulking surgery with a modification of Auchincloss-Kim's technique. Histologic examination of the tissue specimen was performed. The surgical treatment was well tolerated and primary healing was uneventful. After primary wound healing and ambulation of the patients, a delayed ulceration with lymphorrhea developed. It was treated by surgical necrectomy and vacuum-assisted closure leading to complete healing. Mobility of the leg was much improved. Histologic examination revealed massive ectatic lymphatic vessels nonreactive for podoplanin. Debulking surgery can be an adjuvant technique for elephantiasis nostras in advanced lipo-lymphedema. Although delayed postoperative wound healing problems were observed, necrectomy and vacuum-assisted closure achieved a complete healing. Histologic data suggest that the ectatic lymphatic vessels in these patients resemble finding in podoplanin knockout mice. The findings would explain the limitations of decongestive lymphatic therapy and tumescent liposuction in such patients and their predisposition to relapsing erysipelas.

  3. Elephantiasis Nostras Verrucosa (ENV): a complication of congestive heart failure and obesity.

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    Baird, Drew; Bode, David; Akers, Troy; Deyoung, Zachariah

    2010-01-01

    Congestive heart failure (CHF) and obesity are common medical conditions that have many complications and an increasing incidence in the United States. Presented here is a case of a disfiguring skin condition that visually highlights the dermatologic consequences of poorly controlled CHF and obesity. This condition will probably become more common as CHF and obesity increase in the US.

  4. The diagnostic challenge of mapping elephantiasis in the Tigray region of northern Ethiopia.

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    Padovese, Valeska; Marrone, Rosalia; Dassoni, Federica; Vignally, Pascal; Barnabas, Gebre A; Morrone, Aldo

    2016-05-01

    In Ethiopia, lymphatic filariasis and podoconiosis are the two neglected tropical diseases planned to be mapped together within the recently launched Ethiopian neglected tropical diseases master plan (2013-2015). However, other disorders cause tropical lymphedema, and this report aims to identify clinical epidemiological aspects of limb swelling in northern Ethiopia and to provide an algorithm orienting the clinical diagnosis. Medical records of patients with lower limb elephantiasis attending the Italian Dermatological Centre of Mekele, Tigray capital city, over a 4-year period (2005-2009) were retrospectively analyzed. Nine variables were collected from the charts comprising demographic data, job, origin, literacy, clinical, histopathologic, microscopic, and cultural findings. Over a total of 511 patients, lymphedema resulted from trauma (40.7%), chronic venous insufficiency (12.5%), deep mycoses (10.8%), lymphatic filariasis (9.2%), elephantiasis nostras verrucosa (7.0%), tropical ulcer (6.3%), leprosy (4.9%), recurrent infections (3.1%), podoconiosis (1.8%), tuberculosis (1.0%), malignancy (1.3%), Kaposi's sarcoma (1.0%), leishmaniasis (0.2%), and neurofibromatosis (0.2%). Advanced-stage elephantiasis, chronic osteomyelitis, and podoconiosis not previously reported in Tigray were observed. Further epidemiological investigation and training programs addressed to healthcare providers at the peripheral level are needed to detect elephantiasis early, prevent disabilities, and improve patients' quality of life. © 2015 The International Society of Dermatology.

  5. [Penoscrotal elephantiasis].

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    Zugor, V; Horch, R E; Engehausen, D G; Schott, G E

    2007-05-01

    Penoscrotal elephantiasis is not an uncommon clinical picture that may arise as a symptom of many diseases; it is usually a sequela of a recurring inflammatory process, eczema or malignancy. Elephantiasis often occurs after radical operations in the pelvic region. Displacement of lymphatic pathways leads to a local edema which over the course of time may lead to a considerable increase in volume of the patient's genitals or other affected parts. The diagnosis of elephantiasis is not difficult. It is much more difficult to determine which disease has caused the obstruction of the lymphatic pathways. If it is a reversible stage, the object of treatment is to remove the obstruction and reinstate the physiological lymph flow. Conservative measures such as administration of anti-inflammatory drugs and diuretics, physical measures such as baths, massage, elevation of the affected parts and treatment of the underlying disease may be considered. On progression to irreversible elephantiasis a chronic lymphatic edema occurs for which conservative measures will be unsuccessful. For cases where physical and anti-inflammatory measures are unsuccessful, excision and amputation of the affected penoscrotal region is recommended in order to eliminate the functional dysfunction. We report on two cases of penoscrotal elephantiasis, one in a child and the other in an adult man.

  6. Segmental tuberculosis verrucosa cutis

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    Hanumanthappa H

    1994-01-01

    Full Text Available A case of segmental Tuberculosis Verrucosa Cutis is reported in 10 year old boy. The condition was resembling the ascending lymphangitic type of sporotrichosis. The lesions cleared on treatment with INH 150 mg daily for 6 months.

  7. Giant scrotal elephantiasis.

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    Kuepper, Daniel

    2005-02-01

    How much can a man carry? Penoscrotal elephantiasis is a debilitating syndrome. This is a case report of a patient with giant genital elephantiasis secondary to long-standing lymphogranuloma venereum infection in Ethiopia. Complete surgical resection of the pathologic tissue and penile reconstruction was undertaken with good cosmetic and functional results.

  8. Inguinal syndrome with penoscrotal elephantiasis

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    Aggarwal Kamal

    2002-11-01

    Full Text Available Bilateral inguinal adenitis and penoscrotal elephantiasis are uncommonly encountered presentations of Lymphogranuloma venereum. Herein, we report a male who presented with bilateral inguinal bubos alongwith penoscrotal elephantiasis that developed within 6 months of the primary lesion.

  9. Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review.

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    Yimer, Mulat; Hailu, Tadesse; Mulu, Wondemagegn; Abera, Bayeh

    2015-06-01

    Elephantiasis is a symptom of a variety of diseases that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts. Some conditions having this symptom include: Elephantiasis nostras, due to longstanding chronic lymphangitis; Elephantiasis tropica or lymphatic filariasis, caused by a number of parasitic worms, particularly Wuchereria bancrofti; non-filarial elephantiasis or podoconiosis, an immune disease caused by heavy metals affecting the lymph vessels; proteus syndrome, the genetic disorder of the so-called Elephant Man, etc. Podoconiosis is a type of lower limb tropical elephantiasis distinct from lymphatic filariasis. Lymphatic filariasis affects all population at risk, whereas podoconiosis predominantly affects barefoot subsistence farmers in areas with red volcanic soil. Ethiopia is one of the countries with the highest number of podoconiosis patients since many people are at risk to red-clay soil exposure in many parts of the country. The aim of this review was to know the current status and impact of podoconiosis and its relevance to elephantiasis in Ethiopia. To know the epidemiology and disease burden, the literatures published by different scholars were systematically reviewed. The distribution of the disease and knowledge about filarial elephantiasis and podoconiosis are not well known in Ethiopia. It is relatively well studied in southern Ethiopia but data from other parts of the country are limited. Moreover, programmes that focus on diagnosis, treatment, prevention and control of filarial elephantiasis and podoconiosis are also non-existent even in endemic areas. Furthermore, the disease mapping has not been carried out country-wide. Therefore, in order to address these gaps, Ethiopian Ministry of Health needs to take initiative for undertaking concrete research and mapping of the disease in collaboration with stakeholders.

  10. Penoscrotal elephantiasis: Case report

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    Anna Jędrowiak

    2017-04-01

    Full Text Available Genital elephantiasis is characterized by massive growth of genitals as a result of chronic lymphedema caused by numerous infectious and noninfectiuos triggers. In most cases it occurs in filarial endemic zones and is rarely encountered in developed nations. Herein, we report a case of 33-year-old previously healthy patient who presented with rapid penoscrostal enlargement and systemic signs due to probable streptococcal contagion after a surgical treatment of phimosis subsequently complicated with chronic penoscrotal lymphedema. Genital elephantiasis is usually irreversible with systemic therapy alone and frequently requires surgical procedures following the acute stage of the disease.

  11. Penoscrotal elephantiasis: Case report

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    Anna Jędrowiak

    2016-07-01

    Full Text Available Genital elephantiasis is characterized by massive growth of genitals as a result of chronic lymphedema caused by numerous infectious and noninfectiuos triggers. In most cases it occurs in filarial endemic zones and is rarely encountered in developed nations. Herein, we report a case of 33-year-old previously healthy patient who presented with rapid penoscrostal enlargement and systemic signs due to probable streptococcal contagion after a surgical treatment of phimosis subsequently complicated with chronic penoscrotal lymphedema. Genital elephantiasis is usually irreversible with systemic therapy alone and frequently requires surgical procedures following the acute stage of the disease

  12. [A case report: elephantiasis].

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    Karagöz, Ergenekon; Karaahmetoğlu, Gökhan; Acar, Ali; Turhan, Vedat; Oncül, Oral; Görenek, Levent

    2012-01-01

    Klippel-Trenaunay syndrome (KTS) is a rare disease and a syndrome that is characterized by the triad of congenital port wine stains,venous malformations with or without varicose veins, bone or soft tissue hypertrophy. Lymphatic filariasis is a filarial disease which usually occurs with genital anomalies, pathologies associated with lymphedema or elephantiasis caused by a filarial infectious agent. In this case report, a 20-year-old male patient admitted to our clinic for diagnosis and treatment with right leg edema and lesions compatible with dermatological manifestations. In the list of differential diagnosis, filarial elephantiasis was also thought, consequently KTS was diagnosed. (Turkiye Parazitol Derg 2012; 36: 188-90).

  13. Idiopathic scrotal elephantiasis.

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    Hornberger, Brad J; Elmore, James M; Roehrborn, Claus G

    2005-02-01

    Scrotal lymphedema (scrotal elephantiasis) is a condition that has historically been described in areas endemic to filariasis. We present a unique case of a 22-year-old man with idiopathic lymphedema isolated to the scrotum. After acquired causes of lymphedema were ruled out, the patient was treated with scrotectomy and scrotal reconstruction.

  14. Tuberculosis verrucosa cutis

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    Krishnabharath S

    2017-08-01

    Full Text Available We report a case of 23-year-old male patient with tuberculosis verrucous cutis on the foot for a duration of six months without responding to routine treatment. Tuberculosis is a common disease worldwide. Extrapulmonary tuberculosis contributes to 10% of cases. Cutaneous tuberculosis occupies a small spectrum of extrapulmonary tuberculosis. Tuberculosis verrucosa cutis is an exogenous infection occurring in a previously sensitized patient by direct inoculation of the organism. It occurs in sensitized patients with a moderate to high immune response. The diagnosis in our patient was confirmed by history, clinical examination, histopathological examination and the patient’s response to anti-tuberculous therapy.

  15. Vulval Elephantiasis: A Case Report

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    Mohan, Harsh; Bisht, Bhumika; Goel, Poonam; Garg, Geeta

    2012-01-01

    Introduction. Elephantiasis is a chronic manifestation of filariasis; it commonly affects limbs, scrotum, and trunk. Females have lower incidence of filarial infection. Vulval elephantiasis due to filariasis is still rarer. It is difficult to make the diagnosis on histopathology alone, more so in view of the fact that the parasite is usually not identified in tissue sections. Identification of microfilariae in night samples of peripheral blood or seropositivity for filarial antigen is requisi...

  16. Abdominal elephantiasis: a case report.

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    Hanna, Dominique; Cloutier, Richard; Lapointe, Roch; Desgagné, Antoine

    2004-01-01

    Elephantiasis is a well-known condition in dermatology usually affecting the legs and external genitalia. It is characterized by chronic inflammation and obstruction of the lymphatic channels and by hypertrophy of the skin and subcutaneous tissues. The etiology is either idiopathic or caused by a variety of conditions such as chronic filarial disease, leprosy, leishmaniasis, and chronic recurrent cellulites. Elephantiasis of the abdominal wall is very rare. A complete review of the English and French literature showed only two cases reported in 1966 and 1973, respectively. We report a third case of abdominal elephantiasis and we briefly review this entity. We present the case of a 51-year-old woman who had progressively developed an enormous pediculated abdominal mass hanging down her knees. The skin was thickened, hyperpigmented, and fissured. She had a history of multiple abdominal cellulites. She underwent an abdominal lipectomy. Histopathology of the specimen confirmed the diagnosis of abdominal elephantiasis. Abdominal elephantiasis is a rare disease that represents end-stage failure of lymph drainage. Lipectomy should be considered in the management of this condition.

  17. Obesity-Associated Abdominal Elephantiasis

    Directory of Open Access Journals (Sweden)

    Ritesh Kohli

    2013-01-01

    Full Text Available Abdominal elephantiasis is a rare entity. Abdominal elephantiasis is an uncommon, but deformative and progressive cutaneous disease caused by chronic lymphedema and recurrent streptococcal or Staphylococcus infections of the abdominal wall. We present 3 cases of patients with morbid obesity who presented to our hospital with abdominal wall swelling, thickening, erythema, and pain. The abdominal wall and legs were edematous, with cobblestone-like, thickened, hyperpigmented, and fissured plaques on the abdomen. Two patients had localised areas of skin erythema, tenderness, and increased warmth. There was purulent drainage from the abdominal wall in one patient. They were managed with antibiotics with some initial improvement. Meticulous skin care and local keratolytic treatment for the lesions were initiated with limited success due to their late presentation. All three patients refused surgical therapy. Conclusion. Early diagnosis is important for the treatment of abdominal elephantiasis and prevention of complications.

  18. Vulval Elephantiasis: A Case Report

    Science.gov (United States)

    Mohan, Harsh; Bisht, Bhumika; Goel, Poonam; Garg, Geeta

    2012-01-01

    Introduction. Elephantiasis is a chronic manifestation of filariasis; it commonly affects limbs, scrotum, and trunk. Females have lower incidence of filarial infection. Vulval elephantiasis due to filariasis is still rarer. It is difficult to make the diagnosis on histopathology alone, more so in view of the fact that the parasite is usually not identified in tissue sections. Identification of microfilariae in night samples of peripheral blood or seropositivity for filarial antigen is requisite for the correct diagnosis. Case Presentation. A young female presented with progressively increasing vulval swelling over a period of two years. The swelling was soft and measured 5 × 6 cm. Other possible differential diagnoses were excluded, and ancillary tests were performed to reach a conclusive diagnosis of vulval elephantiasis on histopathology. Conclusion. Vulval elephantiasis due to filariasis is rare. Its diagnosis on histopathology is more often by exclusion. High index of suspicion on microscopic findings and corelation with relevant diagnostic tests are required to reach the correct diagnosis. PMID:23198192

  19. Vulval Elephantiasis: A Case Report

    Directory of Open Access Journals (Sweden)

    Harsh Mohan

    2012-01-01

    Full Text Available Introduction. Elephantiasis is a chronic manifestation of filariasis; it commonly affects limbs, scrotum, and trunk. Females have lower incidence of filarial infection. Vulval elephantiasis due to filariasis is still rarer. It is difficult to make the diagnosis on histopathology alone, more so in view of the fact that the parasite is usually not identified in tissue sections. Identification of microfilariae in night samples of peripheral blood or seropositivity for filarial antigen is requisite for the correct diagnosis. Case Presentation. A young female presented with progressively increasing vulval swelling over a period of two years. The swelling was soft and measured 5×6 cm. Other possible differential diagnoses were excluded, and ancillary tests were performed to reach a conclusive diagnosis of vulval elephantiasis on histopathology. Conclusion. Vulval elephantiasis due to filariasis is rare. Its diagnosis on histopathology is more often by exclusion. High index of suspicion on microscopic findings and corelation with relevant diagnostic tests are required to reach the correct diagnosis.

  20. [Penoscrotal elephantiasis: diagnostics and treatment options].

    Science.gov (United States)

    Zugor, V; Horch, R E; Labanaris, A P; Schreiber, M; Schott, G E

    2008-04-01

    Penoscrotal elephantiasis is a symptom that can be caused by local but also by systemic disorders. When the changes are reversible, conservative measures such as physical and antiphlogistic approaches lead to success. In cases of irreversible penoscrotal elephantiasis, excision and amputation of the affected penoscrotal areas are recommended to eliminate the functional disturbances. In all manifestations it is important to prevent and treat those diseases known to cause elephantiasis.

  1. Intensive outpatient treatment of elephantiasis.

    Science.gov (United States)

    Pereira De Godoy, J M; Amador Franco Brigidio, P; Buzato, E; Fátima Guerreiro De Godoy, M

    2012-10-01

    The aim of this paper was to report on a novel approach to the intensive outpatient treatment of elephantiasis of an underprivileged population. Prospective, random study, the diagnosis of lymphedema was clinical and the inclusion of patients was by order of arrival in the treatment center where all were invited to participate in the study. Intensive outpatient therapy was performed for 6 to 8 hours daily over a period of four weeks. Eleven legs with grade III elephantiasis of 8 patients were evaluated in a random prospective study. Three patients were men and five were women with ages ranging between 28 and 66 years old. Treatment included mechanical lymph drainage using the RAGodoy® apparatus for a period of 6 to 8 hours daily and the Godoy & Godoy cervical stimulation technique for 20 minutes per day, both associated to the use of a home-made medical compression stocking using a low-stretch cotton-polyester material. Additionally, manual lymph drainage using the Godoy & Godoy technique was performed for one hour. Perimetry was used to compare measurements made before and after treatment, of the three points of the limb with the largest circumferences. The paired t-test was utilized for statistical analysis with an alpha error greater than 5% (P-value elephantiasis.

  2. Bartoneliasis: fiebre verrucosa del guaitara en colombia

    OpenAIRE

    Patiño Camargo, Luis

    2011-01-01

    En Colombia, al descubrirla, diósele (1) a esta dolencia los siguientes nombres: Bartonellosis, Fiebre verrucosa del Guaitara y Verruga, análoga a la enfermedad de Carrión, Fiebre de Oroya y Verruga Peruana.

  3. Genital elephantiasis and sexually transmitted infections - revisited.

    Science.gov (United States)

    Gupta, Somesh; Ajith, C; Kanwar, Amrinder J; Sehgal, Virendra N; Kumar, Bhushan; Mete, Uttam

    2006-03-01

    Genital elephantiasis is an important medical problem in the tropics. It usually affects young and productive age group, and is associated with physical disability and extreme mental anguish. The majority of cases are due to filariasis; however, a small but significant proportion of patients develop genital elephantiasis due to bacterial sexually transmitted infections (STIs), mainly lymphogranuloma venereum (LGV) and donovanosis. STI-related genital elephantiasis should be differentiated from elephantiasis due to other causes, including filariasis, tuberculosis, haematological malignancies, iatrogenic, or dermatological diseases. Laboratory investigations like microscopy of tissue smear and nucleic acid amplification test for donovanosis, and serology and polymerase chain reaction for LGV may help in the diagnosis, but in endemic areas, in the absence of laboratory facilities, diagnosis largely depends on clinical characteristics. The causative agent of LGV, Chlamydia trachomatis serovar L1-L3, is a lymphotropic organism which leads to the development of thrombolymphangitis and perilymphangitis, and lymphadenitis. Long-standing oedema, fibrosis and lymphogranulomatous infiltration result in the final picture of elephantiasis. Elephantiasis in donovanosis is mainly due to constriction of the lymphatics which are trapped in the chronic granulomatous inflammatory response generated by the causative agent, Calymmatobacterium (Klebsiella) granulomatis. The LGV-associated genital elephantiasis should be treated with a prolonged course of doxycycline given orally, while donovanosis should be treated with azithromycin or trimethoprim-sulphamethoxazole combination given for a minimum of three weeks. Genital elephantiasis is not completely reversible with medical therapy alone and often needs to be reduced surgically.

  4. Nostra Aetate and the Religious Literacy of Catholic Students

    Science.gov (United States)

    Nienhaus, Cyndi

    2013-01-01

    In this article, I take the opportunity of the 50th anniversary of the Second Vatican Council to reassess one of its major products, the declaration Nostra Aetate ("In Our Time"). Following a brief introduction to Nostra Aetate, I describe my experience teaching an undergraduate course on Jewish-Christian Relations built around the…

  5. Europa Nostra medal Tartusse / Karin Hallas-Murula

    Index Scriptorium Estoniae

    Hallas-Murula, Karin, 1957-

    2002-01-01

    Alvar Aalto projekteeritud Tammekannu villa (1932) Tartus pälvis Europa Nostra medali, mis antakse eriti õnnestunult renoveeritud objektile. Villa renoveeriti soome arhitekti Tapani Mustoneni projekti järgi

  6. Studi Karakteristik Biopolimer Gracilaria Verrucosa Sebagai Bahan Penjerap

    OpenAIRE

    Ariyanti, Dessy; Nurcahyani, Intan

    2012-01-01

    The presence of heavy metals such as Cu in industrial wastewater can lead to the environment contamination. The algae Gracilaria verrucosa is intended to be the environmentally friendly polymer used in biosorption process of heavy metals Cu. In this research, the characteristics and adsorption ability of biopolymers Gracilaria verrucosa against heavy metals Cu was studied respectively. Results shown that the maximum biosorption capacity of Gracilaria verrucosa in adsorbing Cu2+ was 38.34 mg/g...

  7. Recurrent Unilateral Vulval Elephantiasis: A Case Report

    Science.gov (United States)

    G., Sampath Kumar; Venkatesh, Shreedhar

    2014-01-01

    Genital elephantiasis is caused by a variety of infective and non infective causes leading to blockage of lymphatic. We are presenting a rare case of recurrent unilateral vulval elephantiasis which has recurred after initial reconstructive surgery. A 38 year old female presented with vulval swelling and on examination there was gross unilateral vulval enlargement. FNAC (Fine needle aspiration cytology) and biopsy were contributory for diagnosis. Patient was started with antibiotics and daily dressing was done till the infection was subsided and the patient was planned for reconstructive surgery. PMID:24971141

  8. Recurrent unilateral vulval elephantiasis: a case report.

    Directory of Open Access Journals (Sweden)

    Lakshmidevi Muralidhar

    2014-06-01

    Full Text Available Genital elephantiasis is caused by a variety of infective and non infective causes leading to blockage of lymphatic. We are presenting a rare case of recurrent unilateral vulval elephantiasis which has recurred after initial reconstructive surgery. A 38 year old female presented with vulval swelling and on examination there was gross unilateral vulval enlargement. FNAC (Fine needle aspiration cytology and biopsy were contributory for diagnosis. Patient was started with antibiotics and daily dressing was done till the infection was subsided and the patient was planned for reconstructive surgery.

  9. Giant scrotal elephantiasis: an idiopathic case.

    Science.gov (United States)

    Dianzani, C; Gaspardini, F; Persichetti, P; Brunetti, B; Pizzuti, A; Margiotti, K; Degener, A M

    2010-01-01

    Scrotal elephantiasis is very rare disease in industrialized countries, where it is mainly due to surgery, irradiation or malignancies. It can be defined as idiopathic only when the possible congenital, infectious and compressive causes are excluded. We report a case of massive scrotal lymphoedema in an adult Caucasian patient, in Italy. He presented an extremely voluminous scrotal mass measuring 50 x 47 x 13 cm (weight 18 kg), which extended below his knees, invalidating all his daily activities. The patient was hospitalized in order to undergo to surgical treatment. Although genetic causes were searched and the possible role of infectious agents and compressive factors was evaluated, no etiology was ascertained. Histopathologic examination showed non-specific chronic inflammation, confirming the diagnosis of idiopathic elephantiasis. One year after surgical treatment, the patient is healthy without recurrence signs.

  10. Genital elephantiasis as a complication of chromoblastomycosis: A diagnosis overlooked

    Science.gov (United States)

    Sharma, Nidhi; Marfatia, Y. S.

    2009-01-01

    Over the decades, causes of genital elephantiasis have changed only to become elusive to etiological diagnosis. This is a case of 20 year old male who presented with genital elephantiasis occurring due to lymphatic obstruction caused by chromoblastomycosis and super added erysipelas. The diagnosis of chromoblastomycosis was clenched by biopsy. We describe this case for the rarity of its occurrence. PMID:21938115

  11. Surgical repair of idiopathic scrotal elephantiasis.

    Science.gov (United States)

    Zacharakis, Evangelos; Dudderidge, Tim; Zacharakis, Emmanouil; Ioannidis, Evangelos

    2008-02-01

    Scrotal lymphedema (scrotal elephantiasis) is uncommon outside of filariasis endemic regions. We present a case of a 65-year-old with idiopathic lymphedema of the scrotum and functional impairment of the penis. The patient underwent surgical excision of the edematous subcutaneous tissues and plastic reconstruction of his penis and scrotum. Three years later, the patient showed no signs of local recurrence, had complete restoration of urinary and sexual function and was extremely satisfied with the result. Surgical management was an effective strategy in the management of scrotal lymphedema in this case.

  12. [Idiopathic scrotal elephantiasis. A case report].

    Science.gov (United States)

    López-Caballero, Ignacio; Sánchez-Ruvalcaba, Itzel; Sánchez-Martinez, Luis Carlos; Hernández-Ordoñez, Octavio; Gómez-Lara, Miguel; Flores-Carrillo, Víctor

    2014-01-01

    Penoscrotal lymphedema (scrotal elephantiasis) is a condition that has been described in areas in which filariasis is endemic. This paper presents a case of a 45-year-old man with idiopathic lymphedema isolated to the scrotum. After acquired causes of lymphedema were ruled out, the patient was treated with scrotectomy and penoscrotal reconstruction. Currently, the patient is receiving follow-up care without evidence of recurrence. Penoscrotal lymphedema may cause symptoms of weakness, immobility and emotional disturbance. Surgery procedure provides a satisfactory cosmetical and functional outcome.

  13. [A text-book case of tropical facial elephantiasis].

    Science.gov (United States)

    Dilu, N-J; Sokolo, R

    2007-02-01

    Tropical facial elephantiasis is a nosological entity which can arise from various underlying causes: von Recklinghausen neurofibromatosis, lymphatic and cutaneodermal filarioses, deep mycosis. We report an exceptional case of tropical facial elephantiasis caused by onchocercosis and entomophtoromycosis (rhinophycomycosis). The patient's facial morphology was noted "hippopotamus-face" or "dog-face". Onchocercosis and entomophtoromycosis are two diseases known to cause facial elephantiasis. We have not however been able to find any case report in the literature of co-morbidity nor any information on factors predictive of concomitant occurrence.

  14. Podoconiosis: non-infectious geochemical elephantiasis.

    Science.gov (United States)

    Davey, Gail; Tekola, Fasil; Newport, Melanie J

    2007-12-01

    This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.

  15. Genital elephantiasis due to donovanosis: forgotten but not gone yet ...

    Science.gov (United States)

    Narang, T; Kanwar, A J

    2012-11-01

    Genital elephantiasis is a disease that is characterized by massive enlargement of the genitalia. Early aetiological diagnosis is of paramount importance so that development of genital elephantiasis can be prevented; otherwise it is not completely reversible with medical therapy and often requires surgical intervention. Chronic mental distress and disability can result as it interferes with daily/routine activities of the affected individual. Over time, the infectious causes of genital elephantiasis have evolved, from syphilis in the pre-penicillin era to donovanosis, lymphogranuloma venereum and recently filariasis, tuberculosis, leishmaniasis, HIV and chromoblastomycosis. With a declining prevalence globally, donovanosis is at risk of being forgotten as a cause of genital swelling; however, it is known to persist for years without treatment and can lead to complications such as lymphoedema and genital mutilation. We herein present a case of genital elephantiasis that was eventually diagnosed as being due to donovanosis.

  16. Magnetic resonance imaging of elephantiasis neuromatosa

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, K.J.; Sully, L.; Preston, B.J. [Department of Radiology, University Hospital, Queen`s Medical Centre, Nottingham (United Kingdom); Ludman, C.N. [Department of Radiology, University Hospital, Queen`s Medical Centre, Nottingham (United Kingdom)]|[Division of Academic Radiology, University Hospital, Queen`s Medical Centre, Nottingham (United Kingdom)

    1998-12-01

    We present the case of a 43-year-old man with neurofibromatosis type 1 who developed elephantiasis neuromatosa of his left leg. The gross limb enlargement was extremely disfiguring, and resulted in such severe disability that he was only able to walk a very short distance using crutches. Previous debulking procedures had resulted in massive blood loss, and prior to attempting further surgical intervention MRI studies were requested. Taking advantage of the excellent tissue characterisation and multiplanar imaging capabilities of MRI, we were able to assess the extent of soft tissue and osseous involvement. The use of recently developed MR angiographic sequences enabled us to non-invasively provide detailed images to assess the relationship of the lesions to the major vessels, as well as the vascular supply and angiographic features of the lesions themselves. This article describes our MRI-based findings, which precluded debulking surgery in this unusual manifestation of neurofibromatosis. (orig.) With 6 figs., 23 refs.

  17. Magnetic resonance imaging of elephantiasis neuromatosa

    International Nuclear Information System (INIS)

    Stevens, K.J.; Sully, L.; Preston, B.J.; Ludman, C.N.

    1998-01-01

    We present the case of a 43-year-old man with neurofibromatosis type 1 who developed elephantiasis neuromatosa of his left leg. The gross limb enlargement was extremely disfiguring, and resulted in such severe disability that he was only able to walk a very short distance using crutches. Previous debulking procedures had resulted in massive blood loss, and prior to attempting further surgical intervention MRI studies were requested. Taking advantage of the excellent tissue characterisation and multiplanar imaging capabilities of MRI, we were able to assess the extent of soft tissue and osseous involvement. The use of recently developed MR angiographic sequences enabled us to non-invasively provide detailed images to assess the relationship of the lesions to the major vessels, as well as the vascular supply and angiographic features of the lesions themselves. This article describes our MRI-based findings, which precluded debulking surgery in this unusual manifestation of neurofibromatosis. (orig.)

  18. Scroto-perineal hidradenitis suppurativa complicated by giant scrotal elephantiasis.

    Science.gov (United States)

    Alharbi, Badr; Shlash, Ahmed; Bedaiwi, Khaled; Hooti, Qais Al; Almohaisen, Abdulrahman; Shlash, Saud; Said, Mohammad

    2015-01-01

    Scrotal elephantiasis has been a recognized complication of inguinal node irradiation, filarial infection, tumor involvement and surgical lymphatic destruction, but has rarely been reported in association with hidradenitis suppurativa (HS). HS, also known as acne inversa, is a chronic and often debilitating disease primarily affecting the axillae, inframammary regions and perineum. The location of the lesions may lead to social embarrassment and failure to seek medical treatment. Scroto-preineal HS complicated by scrotal elephantiasis is a distressing disease. Excisional surgery with reconstruction is the recommended treatment with a high likelihood of good outcome. We present a 38-year-old male patient with long-standing scroto-perineal HS complicated by giant scrotal elephantiasis.

  19. Giant scrotal elephantiasis of inflammatory etiology: a case report

    Science.gov (United States)

    Denzinger, Stefan; Watzlawek, Elke; Burger, Maximilian; Wieland, Wolf F; Otto, Wolfgang

    2007-01-01

    Background Scrotal lymphedema is rare outside endemic filariasis regions in Africa and Asia. It is of variable origin in the western world. Case presentation We present a case of a 40-year-old European man with massive elephantiasis of the scrotum attributed to chronic inflammation of the lower urinary tract caused by urinary outlet obstruction and diabetes mellitus. The patient underwent subtotal scrotectomy saving penis, testes and spermatic cords and followed by scrotal reconstruction with adequate cosmetic and functional outcome. Conclusion In this report we discuss a rare case of scrotal elephantiasis in an European patient, reflect on the etiology and the diagnostic and therapeutic approaches. Surgery can be successful even in giant scrotal elephantiasis. PMID:17543128

  20. Giant scrotal elephantiasis of inflammatory etiology: a case report

    Directory of Open Access Journals (Sweden)

    Denzinger Stefan

    2007-06-01

    Full Text Available Abstract Background Scrotal lymphedema is rare outside endemic filariasis regions in Africa and Asia. It is of variable origin in the western world. Case presentation We present a case of a 40-year-old European man with massive elephantiasis of the scrotum attributed to chronic inflammation of the lower urinary tract caused by urinary outlet obstruction and diabetes mellitus. The patient underwent subtotal scrotectomy saving penis, testes and spermatic cords and followed by scrotal reconstruction with adequate cosmetic and functional outcome. Conclusion In this report we discuss a rare case of scrotal elephantiasis in an European patient, reflect on the etiology and the diagnostic and therapeutic approaches. Surgery can be successful even in giant scrotal elephantiasis.

  1. Scroto-perineal hidradenitis suppurativa complicated by giant scrotal elephantiasis

    Directory of Open Access Journals (Sweden)

    Badr Alharbi

    2015-01-01

    Full Text Available Scrotal elephantiasis has been a recognized complication of inguinal node irradiation, filarial infection, tumor involvement and surgical lymphatic destruction, but has rarely been reported in association with hidradenitis suppurativa (HS. HS, also known as acne inversa, is a chronic and often debilitating disease primarily affecting the axillae, inframammary regions and perineum. The location of the lesions may lead to social embarrassment and failure to seek medical treatment. Scroto-preineal HS complicated by scrotal elephantiasis is a distressing disease. Excisional surgery with reconstruction is the recommended treatment with a high likelihood of good outcome. We present a 38-year-old male patient with long-standing scroto-perineal HS complicated by giant scrotal elephantiasis.

  2. Biodiversity and human-pathogenicity of Phialophora verrucosa and relatives in Chaetothyriales

    NARCIS (Netherlands)

    Li, Y.; Xiao, J.; Hoog, , de G.S.; Wang, X.; Wan, Z.; Yu, J.; Liu, W.; Li, R.

    2017-01-01

    Phialophora as defined by its type species P. verrucosa is a genus of Chaetothyriales, and a member of the group known as ‘black yeasts and relatives’. Phialophora verrucosa has been reported from mutilating human infections such as chromoblastomycosis, disseminated phaeohyphomycosis and mycetoma,

  3. [Idiopathic elephantiasis of the penis: a case report].

    Science.gov (United States)

    Yamamoto, Keisuke; Matsuoka, Yasuhiro; Takao, Tetsuya; Tsujimur, Akira; Okuyama, Akihiko; Kubo, Tateki; Hosokawa, Kou; Kakuta, Yoichi; Yamaguchi, Seiji

    2009-03-01

    We report a case of idiopathic elephantiasis of penis. A 41-year-old man was refered to our hospital with a painful penile swelling and severe miction pain. He had no particular past or familial history, and had never been to tropical or semitropical region. Physical examination showed a prominent swelling and flection of his penis. Magnetic resonance imaging revealed a significant thickening of the penile skin and subcutaneous tissue. Due to the difficulty of voiding, an urethral catheter was placed. The penile skin biopsy showed no malignancy. Under the diagnosis of penile elephantiasis, the resection of abnormal penile skin and penile plasty with the split skin graft from his thigh was performed. Histopathological findings showed nonspecific inflammation. The skin graft was successfully adapted. He could urinate smoothly without pain after the urethral catheter was removed. There has been no recurrence 6 months after the operation. He recovered normal micturition and sexual function.

  4. Podoconiosis - non-filarial geochemical elephantiasis - a neglected tropical disease?

    Science.gov (United States)

    Nenoff, Pietro; Simon, Jan Christoph; Muylowa, Grace K; Davey, Gail

    2010-01-01

    Podoconiosis or mossy foot is a form of non-filarial lymphedema. This geochemical elephantiasis is a disabling condition caused by the passage of microparticles of silica and aluminum silicates through the skin of people walking barefoot in areas with a high content of soil of volcanic origin. Podoconiosis is widespread in tropical Africa, Central America and North India, yet it remains a neglected and under-researched condition. The disabling effects of podoconiosis cause great hardship to patients. It adversely affects the economic (reduced productivity and absenteeism), social (marriage, education, etc.) and psychological (social stigma) well-being of those affected. Podoconiosis can be prevented; the main primary preventive measure is protective footwear. Secondary measures include a strict hygiene regimen and compression therapy, which can reverse initial lesions. Tertiary approaches include surgical management, such as shaving operations to reduce hyperplastic and verrucous elephantiasis.

  5. Elephantiasis of the external genitalia: A sequel to cutaneous tuberculosis

    Directory of Open Access Journals (Sweden)

    Padmavathy L

    2009-01-01

    Full Text Available Tuberculosis continues to be an important public health problem and cutaneous tuberculosis constitutes a minor proportion of extra pulmonary manifestations of tuberculosis. Elephantiasis of the external genitalia, as a sequel to cutaneous tuberculosis, in a 40-year-old diabetic lady is being reported for its rarity. The patient also had lesions of healed scrofuloderma of 27 years′ duration, in both axillae, with residual pedunculated nodules.

  6. The burden of non-filarial elephantiasis in Ethiopia.

    Science.gov (United States)

    Animut, Abebe

    2007-12-01

    Although known for many years, non-filarial elephantiasis remains a public health problem in tropical Africa, including the farming community of Ethiopia. The problem may be exacerbated in women who shoulder most of the burden of agricultural labour in the countryside. The intention of this brief review is to emphasise the burden of the disease and to alert researchers and organisations concerned with health care and prevention.

  7. Optimum Fermentation Process for Red Macroalgae Gelidium latifolium and Gracillaria verrucosa

    Directory of Open Access Journals (Sweden)

    Mujizat Kawaroe

    2015-12-01

    Full Text Available Red macroalgae have the potential to be processed into bioethanol due to their high carbohydrate and low lignin content. Gelidium latifolium and Gracilaria verrucosa are red macroalgae commonly found in Indonesian seas. Sometimes an over-supply of red macroalgae is rejected by the food industry, which opens up opportunities for others uses, e.g. for producing bioethanol. The objectives of this research were to analyze the influence of sulfuric acid concentration on hydrolysis of G. latifolium and G. verrucosa and to calculate the optimum fermentation process to produce bioethanol. G. latifolium and G. verrucosa were hydrolyzed using H2SO4 at concentrations of 1%, 2%, 3%, and 4%, at a temperature of 121 °C and a pressure of 1.5 bar for 45 minutes. The process of fermentation was done using Saccharomyces cerevisiae in anaerobic conditions for 4, 5, 6 and 7 days. The results show that the optimum H2SO4 concentrations to hydrolyze G. latifolium and G. verrucosa were 1% and 2% respectively. The number of S. cerevisiae cells in hydrolysate G. latifolium and G. verrucosa increased in the third adaptation. S. cerevisiae can convert sugar from G. latifolium and G. verrucosa into bioethanol through fermentation. The highest bioethanol yields were achieved on days five and six. Therefore, red macroalgae can be seen as a potential raw material for bioethanol production.

  8. Revision of the orb-weaving spider genus Verrucosa McCook, 1888 (Araneae, Araneidae).

    Science.gov (United States)

    Lise, Arno A; Kesster, Cynara C; Da Silva, Estevam L Cruz

    2015-02-25

    The araneid spider genus Verrucosa McCook, 1888 is revised. Five of the seven previously known species, V. arenata (Walckenaer, 1841), V. lampra Soares & Camargo, 1948, V. meridionalis (Keyserling, 1892), V. undecimvariolata (O. Pickard-Cambridge, 1889) and V. zebra (Keyserling, 1892), are redescribed and illustrated. In addition, 37 new species of Verrucosa from the Neotropical region are described and illustrated: V. cachimbo n. sp., V. tarapoa n. sp., V. scapofracta n. sp., V. carara n. sp., V. latigastra n. sp., V. guatopo n. sp., V. cuyuni n. sp., V. benavidesae n. sp., V. rancho n. sp., V. excavata n. sp., V. meta n. sp., V. levii n. sp., V. chanchamayo n. sp., V. manauara n. sp., V. brachiscapa n. sp., V. macarena n. sp., V. pedrera n. sp., V. lata n. sp., V. galianoae n. sp., V. suaita n. sp., V. coroico n. sp., V. florezi n. sp., V. hoferi n. sp., V. caninde n. sp., V. opon n. sp., V. silvae n. sp., V. avilesae n. sp., V. tuberculata n. sp., V. alvarengai n. sp., V. apuela n. sp., V. bartica n. sp., V. cajamarca n. sp., V. canje n. sp., V. cuyabenoensis n. sp., V. sergipana n. sp., V. simla n. sp. and V. rhea n. sp. Mahadiva reticulata O. P.-Cambridge, 1889 is removed from the synonymy of Verrucosa arenata (Walckenaer, 1841) and is recognized as a valid species, Verrucosa reticulata. Araneus cylicophorus Badcock, 1932 is transferred to Verrucosa by Mello-Leitão (1946) removed from the synonymy of Verrucosa meridionalis (Keyserling, 1892) and recognized as a valid species. The male of Verrucosa meridionalis (Keyserling, 1892) is described for the first time. Distributional maps are provided for all species.

  9. Control of Lymphorrhea and Treatment of Warty Excrescences in Elephantiasis

    Directory of Open Access Journals (Sweden)

    José Maria Pereira de Godoy

    2012-01-01

    Full Text Available The aim of this study is to report the control of lymphorrhea in the intensive treatment of elephantiasis, using an Unna boot. The case of a 29-year-old female patient is reported. This young patient evolved with the more serious form of lymphedema, elephantiasis, after surgical treatment of an abdominal neoplasm and radiotherapy. Warty excrescences were present on both legs and genitalia where lymphorrhea was constant. The patient arrived at the Godoy's Clinic for treatment. She was weighed and perimetric evaluations were made at the start of treatment and thereafter every day during an intensive outpatient treatment of eight hours daily for three weeks. Treatment included manual lymph drainage, mechanical lymph drainage using the RA Godoy device, and the continuous use of compression stockings with adjustments made every three hours. An Unna boot was employed as compression at sites of dermal lesions (warty excrescences with overlapping use of individualized compression stockings that were individually adapted. The Unna boot was renewed every two days during the first week and every 3 days during the second and third weeks. By the end of this course of treatment, most of the warty excrescences had reduced in size or even disappeared and the lymphorrhea was controlled.

  10. Evaluation of the pathology, pathogenesis and aetiology of auricular elephantiasis in slaughter pigs.

    Science.gov (United States)

    Kvist, P H; Jensen, E S; Aalbaek, B; Jensen, H E

    2002-12-01

    Ears from slaughter pigs with auricular elephantiasis (n = 24) and the corresponding lymph nodes (lnn.) (n = 26) were grossly, histopathologically and microbiologically examined. Immunostaining for IgM, IgG, Cd3epsilon and bacterial antigens of Arcanobacterium pyogenes and Staphylococcus aureus was performed by indirect enzyme-based techniques. Ears were variably thickened depending on the sampled area (basis, centre and apex). However, at all locations the thickness, the length from basis to apex and the weigh of whole ears with elephantiasis were significantly increased (P elephantiasis is a chronic pyogranulomatous inflammation that is frequently positive for S. aureus and is lymphogenically spread. Therefore, the lesions of the ears with auricular elephantiasis and the corresponding lnn. should be termed auricular botryomycosis and botryomycotic lymphadenitis, respectively. Moreover, as the disease is observed frequently in slaughter pigs it must also be considered according to the welfare of the animals and in relation to post-mortem meat inspection.

  11. Antibacterial activity of red algae (Gracilaria verrucosa) extract against Escherichia coli and Salmonella typhimurium

    Science.gov (United States)

    Dayuti, S.

    2018-04-01

    Red alga was widely used in several fields, including food, feed, phamacy and industrial point of view. The chemical analysis showed that red alga contained terpenoid, acetogenic, and aromatic compounds, which have a wide range of biological activities, such as anti-micobial, anti-inflammatory and anti-viral. The objectives of this research was to evaluate the effect of extraction solvent and time on antibacterial activity of red alga (Gracilaria verrucosa), and to explore the bioactive compound contained within Gracilaria verrucosa. The method in this study used descriptive reseach. These findings revealed that the highest inhibition activity among all extracts was obtained with the ratio of methanol:aquades (75:25) and extraction time around 72 hours against Escherichia coli and Salmonella typhimurium. The bioactive compounds of Gracilaria verrucosa tested by phytochemical analysisi consisted of flavonoid, alkaloid, and saponin. Those secondary metabolites may be approximated as antibactial substances.

  12. Sesquiterpene Lactones from Gynoxys verrucosa and their Anti-MRSA Activity

    Science.gov (United States)

    Ordóñez, Paola E.; Quave, Cassandra L.; Reynolds, William F.; Varughese, Kottayil I.; Berry, Brian; Breen, Philip J.; Malagón, Omar; Smeltzer, Mark S.; Compadre, Cesar M.

    2011-01-01

    Ethnopharmacological relevance Because of its virulence and antibiotic resistance, Staphylococcus aureus is a more formidable pathogen now than at any time since the pre-antibiotic era. In an effort to identify and develop novel antimicrobial agents with activity against this pathogen, we have examined Gynoxys verrucosa Wedd (Asteraceae), an herb used in traditional medicine in southern Ecuador for the treatment and healing of wounds. Materials and Methods The sesquiterpene lactones leucodine (1) and dehydroleucodine (2) were extracted and purified from the aerial parts of G. verrucosa, and their structure was elucidated by spectroscopic methods and single-crystal X-ray analysis. The in vitro anti-microbial activity of G. verrucosa extracts and its purified constituents was determined against six clinical isolates including S. aureus and Staphylococcus epidermidis strains with different drug-resistance profiles, using the microtiter broth method. Results Compound 1 has very low activity, while compound 2 has moderate activity with MIC50s between 49 and195 μg/mL. The extract of G. verrucosa has weak activity with MIC50s between 908 and 3290 μg/mL. Conclusions We are reporting the full assignment of the 1H-NMR and 13C-NMR of both compounds, and the crystal structure of compound 2, for the first time. Moreover, the fact that compound 2 has antimicrobial activity and compound 1 does not, demonstrates that the exocyclic conjugated methylene in the lactone ring is essential for the antimicrobial activity of these sesquiterpene lactones. However, the weak activity observed for the plants extracts, does not explain the use of G. verrucosa in traditional medicine for the treatment of wounds and skin infections. PMID:21782013

  13. Unexpected death in elephantiasis due to an abnormal life-style.

    Science.gov (United States)

    Sato, Hiroaki; Tanaka, Toshiko; Kasai, Kentaro; Kita, Toshiro; Tanaka, Noriyuki

    2009-11-01

    A 22-year-old man was found dead after he had continued to sit on a reclining chair for 2 years. He had consumed an unbalanced diet, kept wearing the same pair of socks and never washed himself for the term. His skin of bilateral crura developed into elephantiasis with severely festered ulcers on its surface. At autopsy, subcutaneous edema was significant in his lower limbs, and chronic circulatory disturbance of lymphoducts and veins was observed histologically. There were no crucial findings to account for chronic edema in the lower limbs. It has been reported that maintaining a seated posture obstructs both lymphoducts and veins because of bending the groin, decreases their return flow by inducing muscular atrophy, and causes subcutaneous edema in the lower limbs. Oligotrophia and dirt on his limbs might have exacerbated the chronic edema in elephantiasis. We concluded that a long-term abnormal life-style had caused fatal elephantiasis.

  14. Dominance of Endozoicomonas bacteria throughout coral bleaching and mortality suggests structural inflexibility of the Pocillopora verrucosa microbiome

    KAUST Repository

    Pogoreutz, Claudia; Radecker, Nils; Cardenas, Anny; Gä rdes, Astrid; Wild, Christian; Voolstra, Christian R.

    2018-01-01

    sequences. This dominance of Endozoicomonas even under conditions of coral bleaching and mortality suggests the bacterial community of P. verrucosa may be rather inflexible and thereby unable to respond or acclimatize to rapid changes in the environment

  15. Abraham Joshua Heschel and Nostra Aetate: Shaping the Catholic Reconsideration of Judaism during Vatican II

    Directory of Open Access Journals (Sweden)

    Joshua Furnal

    2016-06-01

    Full Text Available Although Nostra Aetate is only comprised of five short paragraphs, this document represents a turning point, not just for Catholic-Jewish relations, but also sketches the fundamental aims of embodying the Christian faith in a pluralistic age. There is a complex but important narrative that needs to be revisited so that we do not forget the ways in which Catholic learning has developed, and how this development has often been prompted by non-Catholics. In this article, I will re-examine some crucial details in the back-story of the formulation of Nostra Aetate and offer some observations about the potential consequences of omitting these details. My argument is that some recent events and scholarship suffer from a form of amnesia about the role that Jewish people have played in the development of Catholic learning—a form of amnesia that manifests in explicit proselytizing tendencies. In particular, I want to highlight the role that Rabbi Abraham Joshua Heschel played during the Second Vatican Council as an instructive example for Catholic-Jewish dialogue today.

  16. The Diplomat and the Pioneer in Jewish-Catholic relations prior to Nostra Aetate: Jo Willebrands and Toon Ramselaar

    NARCIS (Netherlands)

    Poorthuis, M.J.H.M.

    2014-01-01

    A combined search of documents in the secret archives of the Vatican and of hith-erto unexplored Dutch archives sheds new light on the genesis of Nostra aetate, the declaration of Vatican II, mainly on Judaism. Two Dutch Catholics exercised a decisive influence upon the making of this declaration:

  17. Parasitological, serological and clinical evidence for high prevalence of podoconiosis (non-filarial elephantiasis) in Midakegn district, central Ethiopia.

    Science.gov (United States)

    Geshere Oli, Geleta; Tekola Ayele, Fasil; Petros, Beyene

    2012-06-01

    To determine whether the elephantiasis in Midakegn district, central Ethiopia, is filarial or non-filarial (podoconiosis) using serological, parasitological and clinical examinations, and to estimate its prevalence. At house-to-house visits in 330 randomly selected households, all household members who had elephantiasis were interviewed and clinically examined at the nearby health centre to confirm the presence of elephantiasis, check the presence of scrotal swelling and rule out the other causes of lymphoedema. A midnight blood sample was obtained from each participant with elephantiasis for microscopic examination of Wuchereria bancrofti microfilaria. A daytime blood sample was obtained from half of the participants for serological confirmation using the immuno-chromatographic test card. Consistent with the features of podoconiosis, none of the elephantiasis cases had consistently worn shoes since childhood; 94.3% had bilateral swelling limited below the level of the knees; no individual had thigh or scrotal elephantiasis; parasitological test for microfilariae and serological tests for W. bancrofti antigen were negative in all samples. The prevalence of the disease was 7.4% and it peaked in the third decade of life, the most economically active age. Midakegn District has a high prevalence of podoconiosis and no filarial elephantiasis. Prevention, treatment and control of podoconiosis must be among the top priorities of public health programmes. © 2012 Blackwell Publishing Ltd.

  18. A case report of surgical debulking for a huge mass of elephantiasis neuromatosa

    Science.gov (United States)

    Hoshi, Manabu; Ieguchi, Makoto; Taguchi, Susumu; Yamasaki, Shinya

    2009-01-01

    Achievement of a safe outcome for an extensive mass with hypervascularity in the extremities requires a surgical team skilled in musculoskeletal oncology. We report debulking surgery for a huge mass of elephantiasis neuromatosa in the right leg of a 56-year old man using the novel Ligasure® vessel sealing system. PMID:21139882

  19. A case report of surgical debulking for a huge mass of elephantiasis neuromatosa

    Directory of Open Access Journals (Sweden)

    Shinya Yamasaki

    2009-07-01

    Full Text Available Achievement of a safe outcome for an extensive mass with hypervascularity in the extremities requires a surgical team skilled in musculoskeletal oncology. We report debulking surgery for a huge mass of elephantiasis neuromatosa in the right leg of a 56-year old man using the novel Ligasure® vessel sealing system.

  20. Study of heavy metals in Lake Abbaya, Ethiopia, and the incidence of non-parasitic elephantiasis

    Energy Technology Data Exchange (ETDEWEB)

    Klein, A.E.

    1977-01-01

    Samples of surface water from Lake Abbaya, Ethiopia, and from nearby hot springs, have been analysed for heavy metals and other consituents. Significant levels of mercury and arsenic were observed. These findings may be relevant to the high incidence of non-parasitic elephantiasis in the immediate vicinity of the lake.

  1. Mater Nostra: The Anti-blasphemy Message of the Feminist Punk-Prayer

    Directory of Open Access Journals (Sweden)

    Elena Ivanovna Volkova

    2014-12-01

    Full Text Available In this essay I develop a blasphemy counter-discourse arguing that it was ecclesial and state authorities who committed blasphemies, which were condemned by Pussy Riot’s punk-prayer. Thus, the performance in this respect may be interpreted as an anti-blasphemy protest. The blasphemy list includes the collaboration of the church with the authoritarian state, known as heresy of Sergianism; Caesar and Temple idolatry, blasphemy against the Holy Spirit, Virgin Mary and Folly for Christ’s sake. The punk-prayer may be interpreted as a feminine version of the Lord’s Prayer – Mater Nostra. Several corporeal narratives in the background – women’s dress code and rape debates, Virgin Mary’s belt, and its alleged miraculous ability to help women to deliver a baby – may be seen as allegories of feminist vs. patriarchal opposition in Russian religious and political culture.

  2. Limits to physiological plasticity of the coral Pocillopora verrucosa from the central Red Sea

    Science.gov (United States)

    Ziegler, Maren; Roder, Cornelia M.; Büchel, Claudia; Voolstra, Christian R.

    2014-12-01

    Many coral species display changing distribution patterns across coral reef depths. While changes in the underwater light field and the ability to associate with different photosynthetic symbionts of the genus Symbiodinium explain some of the variation, the limits to physiological plasticity are unknown for most corals. In the central Red Sea, colonies of the branching coral Pocillopora verrucosa are most abundant in shallow high light environments and become less abundant in water depths below 10 m. To further understand what determines this narrow distribution, we conducted a cross-depths transplant experiment looking at physiological plasticity and acclimation in regard to depth. Colonies from 5, 10, and 20 m were collected, transplanted to all depths, and re-investigated after 30 and 210 d. All coral colonies transplanted downward from shallow to deep water displayed an increase in photosynthetic light-harvesting pigments, which resulted in higher photosynthetic efficiency. Shallow-water specimens transplanted to deeper water showed a significant decrease in total protein content after 30 and 210 d under low light conditions compared to specimens transplanted to shallow and medium depths. Stable isotope data suggest that heterotrophic input of carbon was not increased under low light, and consequently, decreasing protein levels were symptomatic of decreasing photosynthetic rates that could not be compensated for through higher light-harvesting efficiency. Our results provide insights into the physiological plasticity of P. verrucosa in changing light regimes and explain the observed depth distribution pattern. Despite its high abundance in shallow reef waters, P. verrucosa possesses limited heterotrophic acclimation potential, i.e., the ability to support its mainly photoautotrophic diet through heterotrophic feeding. We conclude that P. verrucosa might be a species vulnerable to sudden changes in underwater light fields resulting from processes such as

  3. Limits to physiological plasticity of the coral Pocillopora verrucosa from the central Red Sea

    KAUST Repository

    Ziegler, M.

    2014-07-26

    Many coral species display changing distribution patterns across coral reef depths. While changes in the underwater light field and the ability to associate with different photosynthetic symbionts of the genus Symbiodinium explain some of the variation, the limits to physiological plasticity are unknown for most corals. In the central Red Sea, colonies of the branching coral Pocillopora verrucosa are most abundant in shallow high light environments and become less abundant in water depths below 10 m. To further understand what determines this narrow distribution, we conducted a cross-depths transplant experiment looking at physiological plasticity and acclimation in regard to depth. Colonies from 5, 10, and 20 m were collected, transplanted to all depths, and re-investigated after 30 and 210 d. All coral colonies transplanted downward from shallow to deep water displayed an increase in photosynthetic light-harvesting pigments, which resulted in higher photosynthetic efficiency. Shallow-water specimens transplanted to deeper water showed a significant decrease in total protein content after 30 and 210 d under low light conditions compared to specimens transplanted to shallow and medium depths. Stable isotope data suggest that heterotrophic input of carbon was not increased under low light, and consequently, decreasing protein levels were symptomatic of decreasing photosynthetic rates that could not be compensated for through higher light-harvesting efficiency. Our results provide insights into the physiological plasticity of P. verrucosa in changing light regimes and explain the observed depth distribution pattern. Despite its high abundance in shallow reef waters, P. verrucosa possesses limited heterotrophic acclimation potential, i.e., the ability to support its mainly photoautotrophic diet through heterotrophic feeding. We conclude that P. verrucosa might be a species vulnerable to sudden changes in underwater light fields resulting from processes such as

  4. Limits to physiological plasticity of the coral Pocillopora verrucosa from the central Red Sea

    KAUST Repository

    Ziegler, M.; Roder, C.M.; Buchel, C.; Voolstra, Christian R.

    2014-01-01

    Many coral species display changing distribution patterns across coral reef depths. While changes in the underwater light field and the ability to associate with different photosynthetic symbionts of the genus Symbiodinium explain some of the variation, the limits to physiological plasticity are unknown for most corals. In the central Red Sea, colonies of the branching coral Pocillopora verrucosa are most abundant in shallow high light environments and become less abundant in water depths below 10 m. To further understand what determines this narrow distribution, we conducted a cross-depths transplant experiment looking at physiological plasticity and acclimation in regard to depth. Colonies from 5, 10, and 20 m were collected, transplanted to all depths, and re-investigated after 30 and 210 d. All coral colonies transplanted downward from shallow to deep water displayed an increase in photosynthetic light-harvesting pigments, which resulted in higher photosynthetic efficiency. Shallow-water specimens transplanted to deeper water showed a significant decrease in total protein content after 30 and 210 d under low light conditions compared to specimens transplanted to shallow and medium depths. Stable isotope data suggest that heterotrophic input of carbon was not increased under low light, and consequently, decreasing protein levels were symptomatic of decreasing photosynthetic rates that could not be compensated for through higher light-harvesting efficiency. Our results provide insights into the physiological plasticity of P. verrucosa in changing light regimes and explain the observed depth distribution pattern. Despite its high abundance in shallow reef waters, P. verrucosa possesses limited heterotrophic acclimation potential, i.e., the ability to support its mainly photoautotrophic diet through heterotrophic feeding. We conclude that P. verrucosa might be a species vulnerable to sudden changes in underwater light fields resulting from processes such as

  5. Left Ulnar Artery Pseudoaneurysm and Left Hand Swelling Simulated by Elephantiasis in a Patient with Neurofibromatosis Type 1

    Directory of Open Access Journals (Sweden)

    Ta-Pin Lee

    2017-06-01

    Full Text Available Elephantiasis is a condition featured by gross enlargement of body parts to massive proportions. Neurofibromatosis type 1 (NF1 is a multisystem genetic disorder. Vascular anomaly is one among the complications of NF1. We report a case of NF1 who had a left hand vascular pseudoaneurysm with left hand swelling mimicking elephantiasis. The characteristics of sonography make it an excellent imaging modality to investigate this sort of superficial vascular lesion.

  6. Reading Nostra Aetate in reverse: a different way of looking at the relationships among religions

    Directory of Open Access Journals (Sweden)

    Peter C. Phan

    2015-12-01

    Full Text Available Nostra Aetate indisputably represented at its promulgation in 1965 a momentous step forward in Catholic theology of religions. But its perspective on other religions still remains deeply "Christianity-centric" in that it views other religions from the Christian vantage-point and uses Christianity as the yardstick to evaluate them. Graphically, its theology of religions may be represented by a series of concentric circles with Christianity occupying the center of the innermost circle and other religions occupying successive circles, with increasing distance from the center, depending on the number of the elements of the true religion, which is Christianity, they possess. How would the "the relation of the Church to non-Christian Religions" (the full title of the Declaration Nostra Aetate look like if we start from other religions and see them on their own terms, as they see themselves, that is, not as "non-Christian," and inquire into their mutual relations?  The essay begins with an examination of the theology of religions implicit in the use of the expression “non-Christian” when referring to religions other than Christianity. It is argued that the “non” is not a neutral descriptive term but represents the “fulfillment theology” of religions prevalent before and during Vatican II. Next a critique of this fulfillment theology is presented showing that it is seriously inadequate for interreligious dialogue. Finally the essay proposes a different way to conceiving the relation between Christianity and other religions (as “other” and not as “non-Christian” by applying the insights of the Jewish-Christian dialogue, especially its rejection of supersessionism, its condemnation of the “teaching of contempt,” and its Trinitarian theology of religion. In summary, the essay attempts to formulate a Christian “kenotic theology of religion,” in which Christianity and the church no longer stand at the normative center toward

  7. [Current wound care in patients with elephantiasis--third-stage lymphedema].

    Science.gov (United States)

    Rucigaj, Tanja Planinsek; Slana, Ana; Leskovec, Nada Kecelj

    2012-10-01

    Lymphedema resulting from fluid accumulation due to impairment in the lymphatic system drainage leads to enlargement of the body part involved. If left untreated, in its third stage it results in elephantiasis. Elephantiasis is frequently accompanied by papillomatosis and lymphocutaneous fistulas with lymphorrhoea, erosions and ulcers, frequently with the loss of function in the respective part of the body. Unlike other chronic wounds, wound healing in lymphedema is highly dependent on the use of combined therapies because local treatment with modern supportive dressings and compression therapy with adhesive and non-adhesive short-stretch systems is only part of the complete treatment. This treatment also includes sub-bandage foamy materials, kinesitherapy with tapes (kinesiotaping), intermittent local application of high-pressure oxygen, breathing exercise, and manual lymph drainage and exercises.

  8. NF1 truncating mutations associated to aggressive clinical phenotype with elephantiasis neuromatosa and solid malignancies.

    Science.gov (United States)

    Ponti, Giovanni; Martorana, Davide; Pellacani, Giovanni; Ruini, Cristel; Loschi, Pietro; Baccarani, Alessio; De Santis, Giorgio; Pollio, Annamaria; Neri, Tauro Maria; Mandel, Victor Desmond; Maiorana, Antonio; Maccio, Livia; Maccaferri, Monia; Tomasi, Aldo

    2014-06-01

    Von Recklinghausen disease is a syndrome characterized by a wide phenotypic variability giving rise to both, cutaneous and visceral benign and malignant neoplasms. The first include cutaneous neurofibromas, subcutaneous and plexiform neurofibromas. The latter can undergo malignant transformation and/or determine elephantiasis neuromatosa. Visceral tumors may include malignant peripheral nerve sheet tumors, gastrointestinal stromal tumors, cerebral gliomas and abdominal neurofibromas. In the present study, the authors discuss the clinical and biomolecular characterization of a cohort of 20 families with a diagnosis of type 1 neurofibromatosis. Clinically, the cohort includes three probands with elephantiasis neuromatosa and a peculiarly high incidence of breast and gastrointestinal cancer. Among the 14 NF1 mutations documented, 10 encoding for a truncated protein have been associated to particularly aggressive clinical phenotypes including elephantiasis neuromatosa, malignant peripheral nerve sheet tumors, breast cancer, gastrointestinal stromal tumors. This effect on protein synthesis, rather than the type of NF1 mutation, is the key to the explanation of the genotype-phenotype correlations in the context of neurofibromatosis type 1. Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  9. Vulval elephantiasis as a result of tubercular lymphadenitis: two case reports and a review of the literature

    Science.gov (United States)

    2010-01-01

    Introduction Elephantiasis as a result of chronic lymphedema is characterized by gross enlargement of the arms, legs or genitalia, and occurs due to a variety of obstructive diseases of the lymphatic system. Genital elephantiasis usually follows common filariasis and lymphogranuloma venereum. It may follow granuloma inguinale, carcinomas, lymph node dissection or irradiation and tuberculosis but this happens rarely. Vulval elephantiasis as a consequence of extensive lymph node destruction by tuberculosis is very rare. We present two very unusual cases of vulval elephantiasis due to tuberculous destruction of the inguinal lymph nodes. Case presentation Two Indian women - one aged 40 years and the other aged 27 years, with progressively increasing vulval swellings over a period of five and four years respectively - presented to our hospital. In both cases, there was a significant history on presentation. Both women had previously taken a complete course of anti-tubercular treatment for generalized lymphadenopathy. The vulval swellings were extremely large: in the first case report, measuring 35 × 25 cm on the right side and 45 × 30 cm on the left side, weighing 20 lb and 16 lb respectively. Both cases were managed by surgical excision with reconstruction and the outcome was positive. Satisfactory results have been maintained during a follow-up period of six years in both cases. Conclusions Elephantiasis of the female genitalia is unusual and it has rarely been reported following tuberculosis. We report two cases of vulval elephantiasis as a consequence of extensive lymph node destruction by tuberculosis, in order to highlight this very rare clinical scenario. PMID:21092075

  10. Vulval elephantiasis as a result of tubercular lymphadenitis: two case reports and a review of the literature

    Directory of Open Access Journals (Sweden)

    Bamal Rahul

    2010-11-01

    Full Text Available Abstract Introduction Elephantiasis as a result of chronic lymphedema is characterized by gross enlargement of the arms, legs or genitalia, and occurs due to a variety of obstructive diseases of the lymphatic system. Genital elephantiasis usually follows common filariasis and lymphogranuloma venereum. It may follow granuloma inguinale, carcinomas, lymph node dissection or irradiation and tuberculosis but this happens rarely. Vulval elephantiasis as a consequence of extensive lymph node destruction by tuberculosis is very rare. We present two very unusual cases of vulval elephantiasis due to tuberculous destruction of the inguinal lymph nodes. Case presentation Two Indian women - one aged 40 years and the other aged 27 years, with progressively increasing vulval swellings over a period of five and four years respectively - presented to our hospital. In both cases, there was a significant history on presentation. Both women had previously taken a complete course of anti-tubercular treatment for generalized lymphadenopathy. The vulval swellings were extremely large: in the first case report, measuring 35 × 25 cm on the right side and 45 × 30 cm on the left side, weighing 20 lb and 16 lb respectively. Both cases were managed by surgical excision with reconstruction and the outcome was positive. Satisfactory results have been maintained during a follow-up period of six years in both cases. Conclusions Elephantiasis of the female genitalia is unusual and it has rarely been reported following tuberculosis. We report two cases of vulval elephantiasis as a consequence of extensive lymph node destruction by tuberculosis, in order to highlight this very rare clinical scenario.

  11. Estado actual de la bartonellosis (fiebre verrucosa. verruga en el continente americano

    Directory of Open Access Journals (Sweden)

    Luis Patiño Camargo

    1940-09-01

    Full Text Available Trabajo Presentado al VIII Congreso Científico Panamericano reunido en Washington D.C. en mayo de 1940 por La grave calamidad que ha constituido para Colombia la epidemia de Bartonellosis o Fiebre Verrucosa en una región septentrional de su territorio; la endemia legendaria de el Perú; el hecho de haberse señalado en los últimos días focos activos en el Ecuador; y la circunstancia verosímil de que las remotas epidemias llamadas "Bubas" en Guatemala hayan sido de Verruga, demuestran que sobre un dilatado territorio, en varias naciones tributarias del Pacífico existen focos de Bartonellosis en el Continente Americano.

  12. The red alga Gracilaria verrucosa (Huds.) papens. As an indicator for metal pollution in Thermaikos Gulf (Greece)

    International Nuclear Information System (INIS)

    Malea, P.; Haritonidis, S.; Kevrekidis, T.

    1999-01-01

    Seasonal samplings of the red alga Gracilaria verrucosa (Huds.) Papens., of the sediment and seawater from three stations (Nea Krini, Biamyl, Perea) distributed along the coast of Thermaikos Gulf were made. Iron, Pb, Zn, Cu and Cd concentrations in the alga and sediment after wet digestion and in the salt left after evaporation of the seawater were measured by flameless AAS (Perkin-Elmer HGA 72)

  13. Effect of temperature on two reef-building corals Pocillopora damicornis and P. verrucosa in the Red Sea

    Directory of Open Access Journals (Sweden)

    Abdulmohsin A. Al-Sofyani

    2013-11-01

    Full Text Available The effects of temperature on two reef building corals Pocilloporadamicornis and P. verrucosa inhabiting the Obhur Creek, a small embayment on thewestern, Red Sea coast of Saudi Arabia, was studied from December 2009 toNovember 2010. The overall annual range of seawater temperature in Obhur Creekwas between 24.5°C and 33°C. Zooxanthellae abundance anddiversity showed seasonal variations: the number of zooxanthellae in P. damicornis was slightly higher than in P. verrucosa, and theabundance of zooxanthellae of both species was low in summer and high duringwinter. The respiration rate of P. verrucosa did not vary between summerand winter, suggesting compensatory acclimation. In contrast, the respiratoryrate in P. damicornis was lower in winter than in summer. During thewinter season the metabolic rate was higher in both species owing to theoptimum seawater temperature (30°C. As a result of the abundance ofzooxanthellae and the optimum seawater temperature, the growth rates of theskeletons of the two coral species were higher in winter and lower in summer.In general, the results showed that P. damicornis is more flexible withrespect to temperature than P. damicornis. The difference inzooxanthellae thermal tolerances at 35°C may be due to the algalgenotypes between the two species, resulting in P. damicornis becomingbleached as the rate of metabolism exceeds the rate of photosynthesis withincreasing temperature.

  14. Treatment of elephantiasis of the leg by fasciotomy and lymphangiectomy with skin preservation in a resource-limited setting: a case report and review.

    Science.gov (United States)

    Kibadi, K

    2018-02-01

    The author reports the surgical management of a patient with elephantiasis of the leg in the Democratic Republic of Congo. A fasciotomy and lymphangiectomy with skin preservation, combined with compression therapy, resulted in significant cosmetic, functional, and social improvement. Although challenging in a resource-limited setting, development of surgical management may make it possible to reduce beliefs that elephantiasis is incurable or due to witchcraft and may reduce time to consultation.

  15. AKTIVITAS ANTIOKSIDAN DAN KADAR FENOLIK TOTAL DARI GANGGANG MERAH (Gracilaria verrucosa L. [Antioxidant Activity and Total Phenolic Content of Red Sea Weed (Gracilaria verrucosa L.

    Directory of Open Access Journals (Sweden)

    Lydia Ninan Lestario*

    2008-12-01

    Full Text Available The aims of this study were to compare the antioxidant activity and the total phenolic content of red sea weed (Gracilaria verrucosa L. from extract of methanol, ethanol, acetone, chloroform and hexane; and the correlation between total phenolic content and the antioxidant activity of each extract; then to determine the chlorophyll a, chlorophyll b, and carotene content of each extract and their correlation with the free radical scavenging activity as well. The antioxidant activity were measured by free radical scavenging method with DPPH and by reducing power method with K4Fe(CN6 as standard, whereas the total phenolic content was measured by Folin Ciocalteu method with gallic acid as standard. Chlorophyll a, chlorophyll b, and carotene were determined by spectrophotometric method based on Lambert-Beer law. The data of antioxidant activity and total phenolic content were statistically analyzed by Randomized Completely Block Design (RCBD with five kinds of solvents as treatments and five replications. Honestly Significant Difference Test (HSDT was used to compare the difference of treatments; whereas the chlorophyll a, chlorophyll b, and carotene content were not statistically analyzed since they were only supplement data. The results showed that the highest of the antioxidant activity by free radical scavenging method was found in acetone extract : 43.43% (BHT: 84.15%; whereas by reducing power method was found in chloroform extract : 0.1756 meq K4Fe(CN6/g extract (BHT : 6.1767 meq K4Fe(CN6/g extract; and the highest of the total phenolic content was also found in acetone extract : 45.29 mg /g extract. There were close correlation between phenolic content and antioxidant activity both by free radical scavenging method and by reducing power method with r (coefficient correlation respectivelly 0.89 and 0.91.Chlorophyll a and carotene had also close correlation with the free radical scaveging activity, but not for chlorophyll b.

  16. Exoemission of Ethiopian soils and the endemicity of non-filarial elephantiasis

    Energy Technology Data Exchange (ETDEWEB)

    Davies, J.E. (Birmingham Univ. (UK). Dept. of Anatomy); Townsend, P.D. (Sussex Univ., Brighton (UK))

    1983-01-01

    Non-filarial elephantiasis is an endemic disease in the bare-footed population of Ethiopia. The distribution of this condition is linked with that of local red clay soil. Recently, thermoluminescence has been successfully used to distinguish between endemic and non-endemic soils. Instrinsic lattice defects, frozen in during cooling of volcanic material, are considered to be responsible for characteristic thermoluminescence signals. However, the biological reactivity of the absorbed soil particles will depend upon their surface properties. Exoemission has therefore been studied in samples from both endemic (5 samples) and non-endemic (4 samples) areas. All samples from endemic areas, on first heating, demonstrate an emission peak at 75/sup 0/C. Post-irradiation storage of samples in a moist atmosphere tends to decrease emissivity while wetting irreversibly reduces the response to irradiation. In an hydrated biological environment, this surface reactivity may be linked to the pathogenicity of the soil particles.

  17. Exoemission of Ethiopian soils and the endemicity of non-filarial elephantiasis

    International Nuclear Information System (INIS)

    Davies, J.E.

    1983-01-01

    Non-filarial elephantiasis is an endemic disease in the bare-footed population of Ethiopia. The distribution of this condition is linked with that of local red clay soil. Recently, thermoluminescence has been successfully used to distinguish between endemic and non-endemic soils. Instrinsic lattice defects, frozen in during cooling of volcanic material, are considered to be responsible for characteristic thermoluminescence signals. However, the biological reactivity of the absorbed soil particles will depend upon their surface properties. Exoemission has therefore been studied in samples from both endemic (5 samples) and non-endemic (4 samples) areas. All samples from endemic areas, on first heating, demonstrate an emission peak at 75 0 C. Post-irradiation storage of samples in a moist atmosphere tends to decrease emissivity while wetting irreversibly reduces the response to irradiation. In an hydrated biological environement, this surface reactivity may be linked to the pathogenicity of the soil particles. (author)

  18. 1,10-Phenanthroline-5,6-Dione–Based Compounds Are Effective in Disturbing Crucial Physiological Events of Phialophora verrucosa

    Science.gov (United States)

    Granato, Marcela Queiroz; Gonçalves, Diego de Souza; Seabra, Sergio Henrique; McCann, Malachy; Devereux, Michael; dos Santos, André Luis Souza; Kneipp, Lucimar Ferreira

    2017-01-01

    Phialophora verrucosa is a dematiaceous fungus able to cause chromoblastomycosis, phaeohyphomycosis and mycetoma. All these fungal diseases are extremely difficult to treat and often refractory to the current therapeutic approaches. Therefore, there is an urgent necessity to develop new antifungal agents to combat these mycoses. In this context, the aim of the present work was to investigate the effect of 1,10-phenanthroline-5,6-dione (phendione) and its metal-based derivatives [Ag(phendione)2]ClO4 = ([Ag(phendione)2]+) and [Cu(phendione)3](ClO4)2.4H2O = ([Cu(phendione)3]2+) on crucial physiological events of P. verrucosa conidial cells. Using the CLSI protocol, we have shown that phendione, [Ag(phendione)2]+ and [Cu(phendione)3]2+ were able to inhibit fungal proliferation, presenting MIC/IC50 values of 12.0/7.0, 4.0/2.4, and 5.0/1.8 μM, respectively. [Cu(phendione)3]2+ had fungicidal action and when combined with amphotericin B, both at sub-MIC (½ × MIC) concentrations, significantly reduced (~40%) the fungal growth. Cell morphology changes inflicted by phendione and its metal-based derivatives was corroborated by scanning electron microscopy, which revealed irreversible ultrastructural changes like surface invaginations, cell disruption and shrinkages. Furthermore, [Cu(phendione)3]2+ and [Ag(phendione)2]+ were able to inhibit metallopeptidase activity secreted by P. verrucosa conidia by approximately 85 and 40%, respectively. Ergosterol content was reduced (~50%) after the treatment of P. verrucosa conidial cells with both phendione and [Ag(phendione)2]+. To different degrees, all of the test compounds were able to disturb the P. verrucosa conidia-into-mycelia transformation. Phendione and its Ag+ and Cu2+ complexes may represent a promising new group of antimicrobial agents effective at inhibiting P. verrucosa growth and morphogenesis. PMID:28194139

  19. Beta Human Papillomavirus Infection Is Prevalent in Elephantiasis and Exhibits a Productive Phenotype: A Case-Control Study.

    Science.gov (United States)

    Carlson, John Andrew; Rady, Peter; Kadam, Pooja; He, Qin; Simonette, Rebecca; Tyring, Stephen

    2017-06-01

    Elephantiasis is considered a cutaneous region of immune deficiency with cobblestone-like surface caused by a wart-like eruption. Verrucosis is a diffuse human papillomavirus (HPV) infection linked to immunodeficiency disorders. The objective of this study was to examine the prevalence of HPV infection in lymphedema and its pathogenic role in elephantiasis. A retrospective case-control study was performed examining lymphedematous skin and controls of peritumoral normal skin. HPV infection was evaluated at the DNA, protein, and histopathologic levels by polymerase chain reaction, immunohistochemistry, and light microscopy, respectively. Overall, 540 HPV DNAs were detected in 120 of 122 cutaneous samples (median 4 HPV DNAs per sample, range 0-9). Compared with controls, no differences existed in type or number of HPVs identified. Instead, a diverse spectrum of HPV-related histopathologies were evident, likely reflecting the multiplicity of HPV genotypes detected. Most notably, increasing histopathologic lymphedema stage significantly correlated with markers of productive HPV infection such as altered keratohyaline granules and HPV L1 capsid expression. Limitations of this study are the absence of normal skin controls not associated with neoplasia or subclinical lymphedema, and lack of assessment of HPV copy number per keratinocyte infected. In conclusion, productive HPV infection, not HPV type or numbers detected, distinguished lymphedematous skin from controls. These findings support the theory that lymphedema creates a region of depressed immunity that permits productive HPV infection, manifested clinically by diffuse papillomatosis, characteristic of elephantiasis.

  20. TREATMENTS OF PLASMA CORONA RADIATION ON SEAWEED Gracilaria Verrucosa (HUDSON PAPENFUSS: Efforts to increase growth and biomass

    Directory of Open Access Journals (Sweden)

    Filemon Jalu N Putra

    2014-12-01

    Full Text Available Gracilaria verrucosa (Hudson Papenfuss has great potential to be farmed in the water resources in Indonesia. As natural resource, the weed has a major contribution in the field of industry both for human food and health. Efforts have been done intensively to increase the production capacity to meet the market demand especially gelatin, both national and international market. One of them is the application of plasma corona irradiation treatments on the weed to improve developmental pathways. The concept of plasma irradiation performed at atmospheric conditions may impact on nitrogen intrusion pathway that is important element in the growth of the weed. The aims of this study are to assess the potential impact of plasma irradiation in improving the growth of G. verrucosa and thus increase their biomass production. The treatments were done using five different duration of plasma irradiation, which were 2, 4, 6, 8, and 10 minutes at a 0,5mA stable source of voltage and 8kV of electrical current. Observations of growth rate include thallus length and biomass of G. verrucosa , that was observed every week for 28 days. The result showed that the growth of weed exhibited better than those without radiation. The best growth was reached in the group of treatment of 8 minutes irradiation, exhibited 65,91g of biomass and 9.5515% growth rate and length of thallus reached 22,33 cm and daily growth rate of 2.9759%. The lowest growth of the weed occurred in the treatment of 10 minutes irradiation, which was 44,82 g biomass, 8.123% growth rate, 17,13 cm thallus length with a daily growth rate of 1.9942%

  1. Biochemical and histopathological effects of the stonefish (Synanceia verrucosa) venom in rats.

    Science.gov (United States)

    Khalil, Ahmad M; Wahsha, Mohammad A; Abu Khadra, Khalid M; Khalaf, Maroof A; Al-Najjar, Tariq H

    2018-02-01

    The Reef Stonefish (Synanceia verrucosa) is one of the most dangerous venomous fish known, and has caused occasional human fatalities. The present study was designed to examine some of the pathological effects of the venom from this fish in Sprague Dawley rats. Crude venom was extracted from venom glands of the dorsal spines of stonefish specimens collected from coral reefs in the Gulf of Aqaba (in the northeastern branch of the Red Sea). The rats were given intramuscular injections of the venom and acute toxicity and effect on selected serum marker enzymes as well as normal architecture of vital organs were evaluated. The rat 24 h LD50 was 38 μg/kg body weight. The serum biochemical markers; alanine transaminase (ALT), lactate dehydrogenase (LDH) and creatine kinase (CK) increased after 6 h of administration of a sub lethal dose of the venom and remained significantly raised at 24 h. Amylase levels also significantly increased after venom injection. The venom caused histological damage manifested as an interstitial hemorrhage, inflammatory cell infiltration, and necrosis. The demonstrated rises in the levels of different critical biochemical parameters in the serum may have led to the observed abnormal morphological changes in these organs. These results may account for some of the clinical manifestations observed in victims of stonefish envenomation. Thus, the presented data provide further in vivo evidence of the stonefish toxic effects that may threaten human life and call for the need for special measures to be considered. Copyright © 2018 Elsevier Ltd. All rights reserved.

  2. Otophyma: a case report and review of the literature of lymphedema (elephantiasis) of the ear.

    Science.gov (United States)

    Carlson, J Andrew; Mazza, Jill; Kircher, Kenneth; Tran, Tien Anh

    2008-02-01

    Phymas (swellings, masses, or bulbs) are considered the end-stage of rosacea and mostly affect the nose (rhinophyma), and rarely involve the chin (gnatophyma), the cheek (metophyma), eyelids (blepharophyma), or ears (otophyma). Herein, we report the case of a 57-year-old man who developed unilateral enlargement of his left ear over 2 years. Biopsy revealed changes of rosaceous lymphedema associated with Demodex infestation. Corticosteroid and minocycline therapies resulted in partial reduction of the ear enlargement. Literature review examining for cases of lymphedema (elephantiasis) of the ear revealed that chronic inflammatory disorders (rosacea (most frequent), psoriasis, eczema), bacterial cellulitis (erysipelas), pediculosis, trauma, and primary (congenital) lymphedema can all lead to localized, lymphedematous enlargement of the ear. Depending on the severity, medical treatment directed at the inflammatory condition for mild, diffuse enlargement to surgical debulking for extensive diffuse enlargement or tumor formation can improve the signs and symptoms of otophyma. Decreased immune surveillance secondary to rosaceous lymphedema may explain why Demodex infestation is common in rosacea and support the suspicion that phymatous skin is predisposed to skin cancer development.

  3. A case of scrotal elephantiasis 30 years after treatment of penile carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Horinaga, Minoru; Masuda, Takeshi; Jitsukawa, Seido [Urawa Municipal Hospital, Saitama (Japan)

    1998-11-01

    A 67-year-old man visited our hospital with complaints of scrotal swelling associated with occasional febrile episodes. Physical examination disclosed a huge scrotal mass, approximately the size of a child`s head, with numerous papillomatous lesions in its surface. His past medical history was significant in that he was diagnosed with penile carcinoma at the age of 35 years old and was treated with partial penectomy followed by radiation and chemotherapy at other hospital. During this admission tumor marker squamous cell carcinoma (SCC) and microbiological tests for microfilariae were both negative. Ultrasound (US), computed tomographic (CT) scan and magnetic resonance imaging (MRI) revealed markedly thickened scrotal skin and small hydrocele with no evidence of local recurrence of the previous penile carcinoma. A percutaneous cystostomy was created because of chronic urinary retention and possible urine extravasation into the scrotum. Histopathological examination of the biopsy specimen from the scrotal mass demonstrated lymphagiectasia consistent with elephantiasis of the scrotum. Surgical excision of this huge scrotal mass was performed in August 1997. The resected tissue weighted 1,400 g. Convalescene was uneventful. He subsequently underwent perineal urethrostomy in place of the suprapubic cystostomy. (author)

  4. Economic costs of endemic non-filarial elephantiasis in Wolaita Zone, Ethiopia.

    Science.gov (United States)

    Tekola, Fasil; Mariam, Damen H; Davey, Gail

    2006-07-01

    Endemic non-filarial elephantiasis or podoconiosis is a chronic and debilitating geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a major public health problem in countries in tropical Africa, Central America and North India. To estimate the direct and the average productivity cost attributable to podoconiosis, and to compare the average productivity time of podoconiosis patients with non-patients. Matched comparative cross sectional survey involving 702 study subjects (patients and non-patients) supplemented by interviews with key informants in Wolaita Zone, southern Ethiopia. Total direct costs of podoconiosis amounted to the equivalent of US$ 143 per patient per year. The total productivity loss for a patient amounted to 45% of the total working days per year, causing a monetary loss equivalent to US$ 63. In Wolaita zone, the overall cost of podoconiosis exceeds US$ 16 million per year. Podoconiosis has enormous economic impact in affected areas. Simple preventive measures (such as use of robust footwear) must be promoted by health policy makers.

  5. Giant elephantiasis neuromatosa in the setting of neurofibromatosis type 1: A case report

    Science.gov (United States)

    PONTI, GIOVANNI; PELLACANI, GIOVANNI; MARTORANA, DAVIDE; MANDEL, VICTOR DESMOND; LOSCHI, PIETRO; POLLIO, ANNAMARIA; PECCHI, ANNARITA; DEALIS, CRISTINA; SEIDENARI, STEFANIA; TOMASI, ALDO

    2016-01-01

    Elephantiasis neuromatosa (EN) can arise from a plexiform neurofibroma of the superficial and deep nerves developing from a hyperproliferation of the perineural connective tissue infiltrating adjacent fat and muscles. To date, the clinical association between EN and neurofibromatosis type 1 (NF1) has been poorly defined, particularly with regard to the role of lymphatic alterations and the consequent lymphedema. The present study reports the clinical and biomolecular features of EN in a NF1 patient with the clear clinical diagnostic criteria of multiple cafè-au-lait macules, neurofibromas, EN, a positive family history and a novel NF1 germline c.1541_1542del mutation. Lymphoscintigraphy (LS) highlighted marked dermal backflow in the affected limb, hypertrophy of the ipsilateral inguinal and external iliac lymph nodes, and a bilateral lower limb lymph flow delay. These data support the hypothesis that an extensive hyperproliferative process involving perineural connective, limb soft tissues, bones and the lymphatic system can be responsible for EN in NF1 patients, on the basis of adipocyte metaplasia triggered by lymphostasis and lymphedema, and bone overgrowth and gigantism caused by chronic hyperemia. LS and magnetic resonance imaging can be efficacious tools in the diagnosis and clinical characterization of the early onset of the disease. PMID:27284375

  6. A case of scrotal elephantiasis 30 years after treatment of penile carcinoma

    International Nuclear Information System (INIS)

    Horinaga, Minoru; Masuda, Takeshi; Jitsukawa, Seido

    1998-01-01

    A 67-year-old man visited our hospital with complaints of scrotal swelling associated with occasional febrile episodes. Physical examination disclosed a huge scrotal mass, approximately the size of a child's head, with numerous papillomatous lesions in its surface. His past medical history was significant in that he was diagnosed with penile carcinoma at the age of 35 years old and was treated with partial penectomy followed by radiation and chemotherapy at other hospital. During this admission tumor marker squamous cell carcinoma (SCC) and microbiological tests for microfilariae were both negative. Ultrasound (US), computed tomographic (CT) scan and magnetic resonance imaging (MRI) revealed markedly thickened scrotal skin and small hydrocele with no evidence of local recurrence of the previous penile carcinoma. A percutaneous cystostomy was created because of chronic urinary retention and possible urine extravasation into the scrotum. Histopathological examination of the biopsy specimen from the scrotal mass demonstrated lymphagiectasia consistent with elephantiasis of the scrotum. Surgical excision of this huge scrotal mass was performed in August 1997. The resected tissue weighted 1,400 g. Convalescene was uneventful. He subsequently underwent perineal urethrostomy in place of the suprapubic cystostomy. (author)

  7. Localized lymphedema (elephantiasis): a case series and review of the literature.

    Science.gov (United States)

    Lu, Song; Tran, Tien Anh; Jones, David M; Meyer, Dale R; Ross, Jeffrey S; Fisher, Hugh A; Carlson, John Andrew

    2009-01-01

    Lymphedema typically affects a whole limb. Rarely, lymphedema can present as a circumscribed plaque or an isolated skin tumor. To describe the clinical and pathologic characteristics and etiologic factors of localized lymphedema. Case-control study of skin biopsy and excision specimens histologically diagnosed with lymphedema and presenting as a localized skin tumor identified during a 4-year period. We identified 24 cases of localized lymphedema presenting as solitary large polyps (11), solid or papillomatous plaques (7), pendulous swellings (4), or tumors mimicking sarcoma (2). Patients were 18 females and 6 males with a mean age of 41 years (range 16-74). Anogenital involvement was most frequent (75%)--mostly vulva (58%), followed by eyelid (13%), thigh (8%) and breast (4%). Causative factors included injury due to trauma, surgery or childbirth (54%), chronic inflammatory disease (rosacea, Crohn's disease) (8%), and bacterial cellulitis (12%). Eighty-five percent of these patients were either overweight (50%) or obese (35%). Compared with a series of 80 patients with diffuse lymphedema, localized lymphedema patients were significantly younger (41 vs. 62 years old, p = 0.0001), had no history of cancer treatment (0% vs. 18%, p = 0.03), and had an injury to the affected site (54% vs. 6%, p = 0.0001). Histologically, all cases exhibited dermal edema, fibroplasia, dilated lymphatic vessels, uniformly distributed stromal cells and varying degrees of papillated epidermal hyperplasia, inflammatory infiltrates and hyperkeratosis. Tumor size significantly and positively correlated with history of cellulitis, obesity, dense inflammatory infiltrates containing abundant plasma cells, and lymphoid follicles (p elephantiasis.

  8. Elephantiasis of non-filarial origin (podoconiosis) in the highlands of north-western Cameroon.

    Science.gov (United States)

    Wanji, S; Tendongfor, N; Esum, M; Che, J N; Mand, S; Tanga Mbi, C; Enyong, P; Hoerauf, A

    2008-09-01

    Lymphoedema, a condition of localized fluid retention, results from a compromised lymphatic system. Although one common cause in the tropics is infection with filarial worms, non-filarial lymphoedema, also known as podoconiosis, has been reported among barefoot farmers in volcanic highland zones of Africa, Central and South America and north-western India. There are conflicting reports on the causes of lymphoedema in the highland regions of Cameroon, where the condition is of great public-health importance. To characterise the focus of lymphoedema in the highlands of the North West province of Cameroon and investigate its real causes, a cross-sectional study was carried out on the adults (aged > or =15 years) living in the communities that fall within the Ndop and Tubah health districts. The subjects, who had to have lived in the study area for at least 10 years, were interviewed, examined clinically, and, when possible, checked for microfilaraemia. The cases of lymphoedema confirmed by ultrasonography and a random sample of the other subjects were also tested for filarial antigenaemia. The interviews, which explored knowledge, attitudes and perceptions (KAP) relating to lymphoedema, revealed that the condition was well known, with each study community having a local name for it. Of the 834 individuals examined clinically, 66 (8.1%) had lymphoedema of the lower limb, with all the clinical stages of this condition represented. None of the 792 individuals examined parasitologically, however, had microfilariae of W. bancrofti (or any other filarial parasite) in their peripheral blood, and only one (0.25%) of the 399 individuals tested for the circulating antigens of W. bancrofti gave a positive result. In addition, none of the 504 mosquitoes caught landing on human bait in the study area and dissected was found to harbour any stage of W. bancrofti. These findings indicate that the elephantiasis seen in the North West province of Cameroon is of non-filarial origin.

  9. Dominance of Endozoicomonas bacteria throughout coral bleaching and mortality suggests structural inflexibility of the Pocillopora verrucosa microbiome.

    Science.gov (United States)

    Pogoreutz, Claudia; Rädecker, Nils; Cárdenas, Anny; Gärdes, Astrid; Wild, Christian; Voolstra, Christian R

    2018-02-01

    The importance of Symbiodinium algal endosymbionts and a diverse suite of bacteria for coral holobiont health and functioning are widely acknowledged. Yet, we know surprisingly little about microbial community dynamics and the stability of host-microbe associations under adverse environmental conditions. To gain insight into the stability of coral host-microbe associations and holobiont structure, we assessed changes in the community structure of Symbiodinium and bacteria associated with the coral Pocillopora verrucosa under excess organic nutrient conditions. Pocillopora -associated microbial communities were monitored over 14 days in two independent experiments. We assessed the effect of excess dissolved organic nitrogen (DON) and excess dissolved organic carbon (DOC). Exposure to excess nutrients rapidly affected coral health, resulting in two distinct stress phenotypes: coral bleaching under excess DOC and severe tissue sloughing (>90% tissue loss resulting in host mortality) under excess DON. These phenotypes were accompanied by structural changes in the Symbiodinium community. In contrast, the associated bacterial community remained remarkably stable and was dominated by two Endozoicomonas phylotypes, comprising on average 90% of 16S rRNA gene sequences. This dominance of Endozoicomonas even under conditions of coral bleaching and mortality suggests the bacterial community of P. verrucosa may be rather inflexible and thereby unable to respond or acclimatize to rapid changes in the environment, contrary to what was previously observed in other corals. In this light, our results suggest that coral holobionts might occupy structural landscapes ranging from a highly flexible to a rather inflexible composition with consequences for their ability to respond to environmental change.

  10. Absence of genetic differentiation in the coral Pocillopora verrucosa along environmental gradients of the Saudi Arabian Red Sea

    Directory of Open Access Journals (Sweden)

    Vanessa eRobitzch

    2015-02-01

    Full Text Available The Red Sea is the world’s northernmost tropical sea. The 2,000 km long, but narrow basin creates distinct environmental conditions along its latitudinal spread. The Red Sea displays a pronounced salinity gradient from 41 to 37 PSU (north to south with an opposing temperature gradient from 21-27°C in the north to 27-33.8°C in the south. The Red Sea further displays a decreasing nutrient gradient from south to north that can also influence underwater light fields due to higher phytoplankton content and turbidity. Despite this strong variation in temperature, salinity, nutrients, and light conditions, the Red Sea supports large and diverse coral reef ecosystems along its nearly entire coastline. Only few studies have targeted whether these prevailing gradients affect genetic connectivity of reef organisms in the Red Sea. In this study, we sampled the abundant reef-building coral Pocillopora verrucosa from ten reefs along a latitudinal gradient in the Red Sea covering an area of more than 850 km. We used nine Pocillopora microsatellite markers to assess the underlying population genetic structure and effective population size. To assure the exclusion of cryptic species, all analyzed specimens were chosen from a single mitochondrial lineage. Despite large distances between sampled regions covering pronounced, but smooth temperature and salinity gradients, no significant genetic population structure was found. Rather, our data indicate panmixia and considerable gene flow among regions. The absence of population subdivision driven by environmental factors and over large geographic distances suggests efficient larval dispersal and successful settlement of recruits from a wide range of reef sites. It also advocates, broadcast spawning as the main reproductive strategy of Pocillopora verrucosa in the Red Sea as reflected by the absence of clones in sampled colonies. These factors might explain the success of Pocillopora species throughout the Indo

  11. Dominance of Endozoicomonas bacteria throughout coral bleaching and mortality suggests structural inflexibility of the Pocillopora verrucosa microbiome

    KAUST Repository

    Pogoreutz, Claudia

    2018-01-25

    The importance of Symbiodinium algal endosymbionts and a diverse suite of bacteria for coral holobiont health and functioning are widely acknowledged. Yet, we know surprisingly little about microbial community dynamics and the stability of host-microbe associations under adverse environmental conditions. To gain insight into the stability of coral host-microbe associations and holobiont structure, we assessed changes in the community structure of Symbiodinium and bacteria associated with the coral Pocillopora verrucosa under excess organic nutrient conditions. Pocillopora-associated microbial communities were monitored over 14 days in two independent experiments. We assessed the effect of excess dissolved organic nitrogen (DON) and excess dissolved organic carbon (DOC). Exposure to excess nutrients rapidly affected coral health, resulting in two distinct stress phenotypes: coral bleaching under excess DOC and severe tissue sloughing (>90% tissue loss resulting in host mortality) under excess DON. These phenotypes were accompanied by structural changes in the Symbiodinium community. In contrast, the associated bacterial community remained remarkably stable and was dominated by two Endozoicomonas phylotypes, comprising on average 90% of 16S rRNA gene sequences. This dominance of Endozoicomonas even under conditions of coral bleaching and mortality suggests the bacterial community of P. verrucosa may be rather inflexible and thereby unable to respond or acclimatize to rapid changes in the environment, contrary to what was previously observed in other corals. In this light, our results suggest that coral holobionts might occupy structural landscapes ranging from a highly flexible to a rather inflexible composition with consequences for their ability to respond to environmental change.

  12. Absence of genetic differentiation in the coral Pocillopora verrucosa along environmental gradients of the Saudi Arabian Red Sea

    KAUST Repository

    Robitzch, Vanessa S.N.; Banguera Hinestroza, Eulalia; Sawall, Yvonne; Al-Sofyani, Abdulmohsin; Voolstra, Christian R.

    2015-01-01

    The Red Sea is the world's northernmost tropical sea. The 2000 km long, but narrow basin creates distinct environmental conditions along its latitudinal spread. The Red Sea displays a pronounced salinity gradient from 41 to 37 PSU (north to south) with an opposing temperature gradient from 21 to 27°C in the north to 27–33.8°C in the south. The Red Sea further displays a decreasing nutrient gradient from south to north that can also influence underwater light fields due to higher phytoplankton content and turbidity. Despite this strong variation in temperature, salinity, nutrients, and light conditions, the Red Sea supports large and diverse coral reef ecosystems along its nearly entire coastline. Only few studies have targeted whether these prevailing gradients affect genetic connectivity of reef organisms in the Red Sea. In this study, we sampled the abundant reef-building coral Pocillopora verrucosa from 10 reefs along a latitudinal gradient in the Red Sea covering an area of more than 850 km. We used nine Pocillopora microsatellite markers to assess the underlying population genetic structure and effective population size. To assure the exclusion of cryptic species, all analyzed specimens were chosen from a single mitochondrial lineage. Despite large distances between sampled regions covering pronounced, but smooth temperature and salinity gradients, no significant genetic population structure was found. Rather, our data indicate panmixia and considerable gene flow among regions. The absence of population subdivision driven by environmental factors and over large geographic distances suggests efficient larval dispersal and successful settlement of recruits from a wide range of reef sites. It also advocates, broadcast spawning as the main reproductive strategy of Pocillopora verrucosa in the Red Sea as reflected by the absence of clones in sampled colonies. These factors might explain the success of Pocillopora species throughout the Indo-Pacific and Arabian

  13. Absence of genetic differentiation in the coral Pocillopora verrucosa along environmental gradients of the Saudi Arabian Red Sea

    KAUST Repository

    Robitzch, Vanessa S.N.

    2015-02-11

    The Red Sea is the world\\'s northernmost tropical sea. The 2000 km long, but narrow basin creates distinct environmental conditions along its latitudinal spread. The Red Sea displays a pronounced salinity gradient from 41 to 37 PSU (north to south) with an opposing temperature gradient from 21 to 27°C in the north to 27–33.8°C in the south. The Red Sea further displays a decreasing nutrient gradient from south to north that can also influence underwater light fields due to higher phytoplankton content and turbidity. Despite this strong variation in temperature, salinity, nutrients, and light conditions, the Red Sea supports large and diverse coral reef ecosystems along its nearly entire coastline. Only few studies have targeted whether these prevailing gradients affect genetic connectivity of reef organisms in the Red Sea. In this study, we sampled the abundant reef-building coral Pocillopora verrucosa from 10 reefs along a latitudinal gradient in the Red Sea covering an area of more than 850 km. We used nine Pocillopora microsatellite markers to assess the underlying population genetic structure and effective population size. To assure the exclusion of cryptic species, all analyzed specimens were chosen from a single mitochondrial lineage. Despite large distances between sampled regions covering pronounced, but smooth temperature and salinity gradients, no significant genetic population structure was found. Rather, our data indicate panmixia and considerable gene flow among regions. The absence of population subdivision driven by environmental factors and over large geographic distances suggests efficient larval dispersal and successful settlement of recruits from a wide range of reef sites. It also advocates, broadcast spawning as the main reproductive strategy of Pocillopora verrucosa in the Red Sea as reflected by the absence of clones in sampled colonies. These factors might explain the success of Pocillopora species throughout the Indo-Pacific and

  14. The Environmentally Sound Aquaculture Strategies Based on Bioaccumulation of Heavy Metal of Lead (Pb) on Seaweed of Gracilaria verrucosa on Aquaculture Areas of MuararejaVillage, Tegal City

    Science.gov (United States)

    Nurjanah; Ambariyanto; Supriharyono; Yulianto, Bambang

    2018-02-01

    Community activities such as industry, trade, animal husbandry and agriculture and ssettlements resulting in heavy metals of lead (Pb) can be accumulated in water, sediment and seaweed Gracillaria verrucosa. It can contaminate ponds and affect aquaculture activities in Tegal. Seaweed Gracilaria verrucosa is afisheries commodity that has economical value and cultivated in the area of aquaculture MuararejaTegal. It can serve as fitoremedian that will help reduce the impact of heavy metal pollution due to its ability to accumulate pollutants. The objective of this study was to analyze bioaccumulation of heavy metals of lead (Pb) and its relationship with water quality management in order to develop seaweed cultivation of Gracillaria verrucosa in ponds in the area of aquaculture MuararejaTegal. The method used in this study is a survey, analysis of heavy metals of lead (Pb) in pond water, sediment and seaweed using Atomic Absorption Spectrophotometer (AAS) and the data were analyzed by descriptive quantitative. Bioconcentration of lead (Pb) during the dry season in pond water, sediment and seaweed Gracillaria verrucosa was measured from 0.003 to 0.025 ppm,5.543 to 23.699 ppm and 0.209 to 0.326 ppm respectively. While in the rainy season bioconcentration of lead (Pb) are from 0.003 to 0.015 ppm, sediment from 6.377 to 9.858 ppm and 0.209 to 0.326 ppm respectively. Bioconcentration of Pb in dry season was higher than in the rainy season and the biggest bioconcentration was found in the sediment pond waters. Pb bioaccumulation low and still below the quality standards of the Ministry of Environment decision 51 of 2004 so that the product is safe for consumption.

  15. Modelling environmental factors correlated with podoconiosis: a geospatial study of non-filarial elephantiasis.

    Science.gov (United States)

    Molla, Yordanos B; Wardrop, Nicola A; Le Blond, Jennifer S; Baxter, Peter; Newport, Melanie J; Atkinson, Peter M; Davey, Gail

    2014-06-20

    The precise trigger of podoconiosis - endemic non-filarial elephantiasis of the lower legs - is unknown. Epidemiological and ecological studies have linked the disease with barefoot exposure to red clay soils of volcanic origin. Histopathology investigations have demonstrated that silicon, aluminium, magnesium and iron are present in the lower limb lymph node macrophages of both patients and non-patients living barefoot on these clays. We studied the spatial variation (variations across an area) in podoconiosis prevalence and the associated environmental factors with a goal to better understanding the pathogenesis of podoconiosis. Fieldwork was conducted from June 2011 to February 2013 in 12 kebeles (administrative units) in northern Ethiopia. Geo-located prevalence data and soil samples were collected and analysed along with secondary geological, topographic, meteorological and elevation data. Soil data were analysed for chemical composition, mineralogy and particle size, and were interpolated to provide spatially continuous information. Exploratory, spatial, univariate and multivariate regression analyses of podoconiosis prevalence were conducted in relation to primary (soil) and secondary (elevation, precipitation, and geology) covariates. Podoconiosis distribution showed spatial correlation with variation in elevation and precipitation. Exploratory analysis identified that phyllosilicate minerals, particularly clay (smectite and kaolinite) and mica groups, quartz (crystalline silica), iron oxide, and zirconium were associated with podoconiosis prevalence. The final multivariate model showed that the quantities of smectite (RR = 2.76, 95% CI: 1.35, 5.73; p = 0.007), quartz (RR = 1.16, 95% CI: 1.06, 1.26; p = 0.001) and mica (RR = 1.09, 95% CI: 1.05, 1.13; p < 0.001) in the soil had positive associations with podoconiosis prevalence. More quantities of smectite, mica and quartz within the soil were associated with podoconiosis prevalence. Together with previous

  16. Use of negative-pressure dressings and split-thickness skin grafts following penile shaft reduction and reduction scrotoplasty in the management of penoscrotal elephantiasis.

    Science.gov (United States)

    Stokes, Tracey H; Follmar, Keith E; Silverstein, Ari D; Weizer, Alon Z; Donatucci, Craig F; Anderson, Everett E; Erdmann, Detlev

    2006-06-01

    From 1988 to 2005, 8 men who presented with penoscrotal elephantiasis underwent penile shaft degloving and reduction scrotoplasty, followed by transplantation of a split-thickness skin graft (STSG) to the penile shaft. The etiology of elephantiasis in these patients included self-injection of viscous fluid and postsurgical obstructive lymphedema. In the 6 most recent cases, negative-pressure dressings were applied over the STSG to promote graft take, and STSG take rate was 100%. The results of our series corroborate those of a previous report, which showed circumferential negative-pressure dressings to be safe and efficacious in bolstering STSGs to the penile shaft. Furthermore, these results suggest that the use of negative-pressure dressings may improve graft take in this patient population.

  17. Genetic differentiation across multiple spatial scales of the Red Sea of the corals Stylophora pistillata and Pocillopora verrucosa

    KAUST Repository

    Monroe, Alison

    2015-12-01

    Observing populations at different spatial scales gives greater insight into the specific processes driving genetic differentiation and population structure. Here we determined population connectivity across multiple spatial scales in the Red Sea to determine the population structures of two reef building corals Stylophora pistillata and Pocillopora verrucosa. The Red sea is a 2,250 km long body of water with extremely variable latitudinal environmental gradients. Mitochondrial and microsatellite markers were used to determine distinct lineages and to look for genetic differentiation among sampling sites. No distinctive population structure across the latitudinal gradient was discovered within this study suggesting a phenotypic plasticity of both these species to various environments. Stylophora pistillata displayed a heterogeneous distribution of three distinct genetic populations on both a fine and large scale. Fst, Gst, and Dest were all significant (p-value<0.05) and showed moderate genetic differentiation between all sampling sites. However this seems to be byproduct of the heterogeneous distribution, as no distinct genetic population breaks were found. Stylophora pistillata showed greater population structure on a fine scale suggesting genetic selection based on fine scale environmental variations. However, further environmental and oceanographic data is needed to make more inferences on this structure at small spatial scales. This study highlights the deficits of knowledge of both the Red Sea and coral plasticity in regards to local environmental conditions.

  18. Massimo Bontempelli y la crítica española de entreguerras: nota sobre la recepción de Nostra Dea en Madrid (1926

    Directory of Open Access Journals (Sweden)

    Martín Rodríguez, Mariano

    2004-06-01

    Full Text Available Massimo Bontempelli's plays are of highly historical importance in the avant-garde. Among them. Nostra Dea (1925 achieved considerable fame and Margarita Xirgu even decided to present it to the public in Madrid as early as 1926. The critics welcomed the innovative experience and praised both the acting and the staging, colourful and consistent with the modern symbolical features of the text, but many did not conceal their disappointment in front of the alleged superficiality of the plot and the characters of the play, whose frivolous humour appeared to conflict with the intended allegory. Only some pointed out that no consistency was to be asked from a play whose main interest was the «pure form». The play was considered nevertheless little more than a modern farce, what may illustrate the mixed reception in Madrid of the supposedly lighter manifestations of the avant-garde theatre.Las obras de Máximo Bontempelli revisten gran importancia histórica en las vanguardias. Nostra Dea (1925, por ejemplo, se hizo bastante famosa y Margarita Xirgu decidió presentarla al público madrileño ya en 1926. Los críticos aplaudieron la innovadora representación, especialmente por la interpretación y la puesta en escena, colorista y ajustada a las características simbólicas modernas del texto, aunque muchos no pudieron ocultar su decepción por la presunta superficialidad del argumento y los personajes de la obra, cuya comicidad frívola parecía disonar de la alegoría pretendida. Sólo algunos señalaron que no había que buscar coherencia alguna en una pieza cuyo interés principal residía en la «pura forma». Aun así, la obra se consideró poco más que una farsa moderna, lo que puede servir de ejemplo de la contradictoria recepción en Madrid de las manifestaciones supuestamente más ligeras del teatro de vanguardia.

  19. The effects of season, aeration and light intensity on the performance of pacific whiteleg shrimp (Litopenaeus vannamei) polycultured with seaweed (Gracilaria verrucosa)

    Science.gov (United States)

    Susilowati, T.; Desrina; Hutabarat, J.; Anggoro, S.; Zainuri, M.; Sarjito; Basuki, F.; Yuniarti, T.

    2018-04-01

    This study was aimed to determine impact of stocking season, additional oxygen supply and light intensity on performance of pacific white leg shrimp (Litopenaeus vannamei) polycultured with seaweed Gracilaria verrucosa. Three sets of experiments were used and each experiment was conducted separately in 3 different season (factor W). Three factors and the interaction, that is, stocking seasons (W1: March-June;. W2 : July-October and W3 : November-February), Oxygen supply (O, with or without supply aeration of 6.5 ppm) and light intensity (with or without addition of light 640 lux) was observed. The experiment was conducted in 16 polyethilen net place in concrete tanks (1.2 m3). Shrimp (average weight 0.1 g and lenght 1.2 cm) with density 94 shrimp/m3 and seaweed 2.188 g/m3, cultured for 94 days. Data collected included absolute growth, specific growth rate (SGR), survival rate (SR) and biomass production of shrimp and seaweed. The result showed that culture period March to June, additonal light and suply DO gave the best result with shrimp absolute growth 13.23 g, SGR 5.09 %/day, SR 99.64 % and biomass production 1.256.36 g/m3. Absolute growth of G. verrucosa was 5.223.75g, SGR 268 %/day and biomass production 12.608.55 g/m3.

  20. Neurofibromatosis, gigantism, elephantiasis neuromatosa and recurrent massive subperiosteal hematoma: a new case report and review of 7 case reports from the literature.

    Science.gov (United States)

    Steenbrugge, F; Poffyn, B; Uyttendaele, D; Verdonk, R; Verstraete, K

    2001-04-01

    The authors report the case of a 13-year-old patient with neurofibromatosis (NF-I), who suffered blunt trauma to the left tibia in 1993. The diagnosis of subperiosteal hematoma was made. Treatment consisted of temporary rest. There was a recurrence in 1996, and the subperiosteal hematoma was drained. In 1997, a shortening osteotomy of the left tibia was performed. However, massive gigantism with elephantiasis of the left leg remained, causing a serious functional and cosmetic problem. In 1999, the leg was amputated above the knee. The literature is reviewed and 7 case reports are compared. The pathogenesis of subperiosteal hematoma is discussed.

  1. 8 Allergenic Composition of Polymerized Allergen Extracts of Betula verrucosa, Dermatophagoides Pteronyssinus and Phleum Pratense

    Science.gov (United States)

    Fernandez-Caldas, Enrique; Cases, Barbara; Tudela, Jose Ignacio; Fernandez, Eva Abel; Casanovas, Miguel; Subiza, Jose Luis

    2012-01-01

    Background Allergoids have been successfully used in the treatment of respiratory allergic diseases. They are modified allergen extracts that allow the administration of high allergen doses, due to their reduced IgE binding capacity.They maintain allergen-specific T-cell recognition. Since they are native allergen extracts that have been polymerized with glutaraldehyde, identification of the allergenic molecules requires more complicated methods. The aim of the study was to determine the qualitative composition of different polymerized extracts and investigate the presence of defined allergenic molecules using Mass spectrometry. Methods Proteomic analysis was carried out at the Proteomics Facility of the Hospital Nacional de Parapléjicos (Toledo, Spain). After reduction and alkylation, proteins were digested with trypsin and the resulting peptides were cleaned using C18 SpinTips Sample Prep Kit; peptides were separated on an Ultimate nano-LC system using a Monolithic C18 column in combination with a precolumn for salt removal. Fractionation of the peptides was performed with a Probot microfraction collector and MS and MS/MS analysis of offline spotted peptide samples were performed using the Applied Biosystems 4800 plus MALDI TOF/TOF Analyzer mass spectrometer. ProteinPilot Software V 2.0.1 and the Paragon algorithm were used for the identification of the proteins. Each MS/MS spectrum was searched against the SwissProt 2010_10 database, Uniprot-Viridiplantae database and Uniprot_Betula database. Results Analysis of the peptides revealed the presence of native allergens in the polymerized extracts: Der p 1, Der p 2, Der p 3, Der p 8 and Der p 11 in D. pteronyssinus; Bet v 2, Bet v 6, Bet v 7 and several Bet v 1 isoforms in B. verrucosa and Phl p 1, Phl p 3, Phl p 5, Phl p 11 and Phl p 12 in P. pratense allergoids. In all cases, potential allergenic proteins were also identified, including ubiquitin, actin, Eenolase, fructose-bisphosphate aldolase, luminal

  2. [Genital elephantiasis: reconstructive treatment of penoscrotal lymphoedema with a myocutaneous M. gracilis flap. Experiences from a District Hospital in Ethiopia].

    Science.gov (United States)

    Prica, S; Donati, O F; Schaefer, D J; Peltzer, J

    2008-08-01

    Genital elephantiasis is an illness leading to serious functional and aesthetic as well as psychosocial impairment. Since the 19th century there have been articles describing methods for surgical ablative treatment of penoscrotal lymphoedema. However, most of these methods ignore the creation a new drainage for the lymph. We now describe a new technique using a myocutaneous M. gracilis muscle flap for the reconstruction of the soft tissue damage resulting from radical excision, thus ensuring drainage of the lymph into the deep muscle compartment of the thigh. In the District Hospital "Mettu-Karl Hospital" in the Ethiopian rain forest region of Illubabor, during a period of 6 months the described surgical procedure was applied to 9 patients suffering from severe forms of this grotesquely disfiguring disease. Two patients presented with combined penoscrotal oedema, while the other 7 patients were suffering from isolated scrotal lymphoedema alone. All patients benefited from reconstruction with a myocutaneous M. gracilis muscle flap after radical excision of the affected tissue. All patients were evaluated after 3 and 12 months postoperatively in the presence of a translator. All nine patients showed a functionally and aesthetically satisfying result after 3 months without postoperative occurrence of infection. The evaluation 12 months postoperatively showed no recurrence of genitoscrotal lymphoedema. All patients reported on having regained normal ability for sexual intercourse and no occurrence of urinary tract infections since the operation. Concerning fertility, no statements could be made. A significant improvement in the quality of life was observed by the regained ability to walk and work and consequently the reintegration of the patients into their socio-economic environment. Radical excision of the affected tissue followed by transferring a functioning lymphatic drainage into the deep muscle compartment of the ipsilateral thigh using a proximally based

  3. Effect of sulfur dioxide and sulfuric acid on the physiological-biochemical processes in the leaves of plants. [Acer negundo; Betula verrucosa

    Energy Technology Data Exchange (ETDEWEB)

    Nikolaevskii, V S; Suslova, V S

    1967-01-01

    In the vicinity of copper-smelting plants, the boxelder (Acer negundo) had an injury rate of 5-10% of a period of years, the European white birch (Betula verrucosa), 60-100%. During the 1st stages of the action of H2SO4 and SO2 on the boxelder, observations were made of an active rise in reducing substances, but in the birch there was intensification of oxidative processes. The discovery of a peak of intensification of oxidative activity after stopping peroxidase activity is explained by the activation of cytochrome oxidase and other oxidative systems. It is suggested that H2SO4 affects the oxidation-reduction conditions in the plants not only through the change in pH of the medium but also biochemically. H2SO4 and SO2 exert similar effects on plants in trials: there is very rapid inactivation of catalase and unique behavior of peroxidase. 8 references, 5 figures.

  4. Spatio-temporal analyses of Symbiodinium physiology of the coral Pocillopora verrucosa along large-scale nutrient and temperature gradients in the Red Sea.

    Science.gov (United States)

    Sawall, Yvonne; Al-Sofyani, Abdulmohsin; Banguera-Hinestroza, Eulalia; Voolstra, Christian R

    2014-01-01

    Algal symbionts (zooxanthellae, genus Symbiodinium) of scleractinian corals respond strongly to temperature, nutrient and light changes. These factors vary greatly along the north-south gradient in the Red Sea and include conditions, which are outside of those typically considered optimal for coral growth. Nevertheless, coral communities thrive throughout the Red Sea, suggesting that zooxanthellae have successfully acclimatized or adapted to the harsh conditions they experience particularly in the south (high temperatures and high nutrient supply). As such, the Red Sea is a region, which may help to better understand how zooxanthellae and their coral hosts successfully acclimatize or adapt to environmental change (e.g. increased temperatures and localized eutrophication). To gain further insight into the physiology of coral symbionts in the Red Sea, we examined the abundance of dominant Symbiodinium types associated with the coral Pocillopora verrucosa, and measured Symbiodinium physiological characteristics (i.e. photosynthetic processes, cell density, pigmentation, and protein composition) along the latitudinal gradient of the Red Sea in summer and winter. Despite the strong environmental gradients from north to south, our results demonstrate that Symbiodinium microadriaticum (type A1) was the predominant species in P. verrucosa along the latitudinal gradient. Furthermore, measured physiological characteristics were found to vary more with prevailing seasonal environmental conditions than with region-specific differences, although the measured environmental parameters displayed much higher spatial than temporal variability. We conclude that our findings might present the result of long-term acclimatization or adaptation of S. microadriaticum to regionally specific conditions within the Red Sea. Of additional note, high nutrients in the South correlated with high zooxanthellae density indicating a compensation for a temperature-driven loss of photosynthetic

  5. Spatio-temporal analyses of Symbiodinium physiology of the coral Pocillopora verrucosa along large-scale nutrient and temperature gradients in the Red Sea.

    Directory of Open Access Journals (Sweden)

    Yvonne Sawall

    Full Text Available Algal symbionts (zooxanthellae, genus Symbiodinium of scleractinian corals respond strongly to temperature, nutrient and light changes. These factors vary greatly along the north-south gradient in the Red Sea and include conditions, which are outside of those typically considered optimal for coral growth. Nevertheless, coral communities thrive throughout the Red Sea, suggesting that zooxanthellae have successfully acclimatized or adapted to the harsh conditions they experience particularly in the south (high temperatures and high nutrient supply. As such, the Red Sea is a region, which may help to better understand how zooxanthellae and their coral hosts successfully acclimatize or adapt to environmental change (e.g. increased temperatures and localized eutrophication. To gain further insight into the physiology of coral symbionts in the Red Sea, we examined the abundance of dominant Symbiodinium types associated with the coral Pocillopora verrucosa, and measured Symbiodinium physiological characteristics (i.e. photosynthetic processes, cell density, pigmentation, and protein composition along the latitudinal gradient of the Red Sea in summer and winter. Despite the strong environmental gradients from north to south, our results demonstrate that Symbiodinium microadriaticum (type A1 was the predominant species in P. verrucosa along the latitudinal gradient. Furthermore, measured physiological characteristics were found to vary more with prevailing seasonal environmental conditions than with region-specific differences, although the measured environmental parameters displayed much higher spatial than temporal variability. We conclude that our findings might present the result of long-term acclimatization or adaptation of S. microadriaticum to regionally specific conditions within the Red Sea. Of additional note, high nutrients in the South correlated with high zooxanthellae density indicating a compensation for a temperature-driven loss of

  6. Spatio-Temporal Analyses of Symbiodinium Physiology of the Coral Pocillopora verrucosa along Large-Scale Nutrient and Temperature Gradients in the Red Sea

    KAUST Repository

    Sawall, Yvonne

    2014-08-19

    Algal symbionts (zooxanthellae, genus Symbiodinium) of scleractinian corals respond strongly to temperature, nutrient and light changes. These factors vary greatly along the north-south gradient in the Red Sea and include conditions, which are outside of those typically considered optimal for coral growth. Nevertheless, coral communities thrive throughout the Red Sea, suggesting that zooxanthellae have successfully acclimatized or adapted to the harsh conditions they experience particularly in the south (high temperatures and high nutrient supply). As such, the Red Sea is a region, which may help to better understand how zooxanthellae and their coral hosts successfully acclimatize or adapt to environmental change (e. g. increased temperatures and localized eutrophication). To gain further insight into the physiology of coral symbionts in the Red Sea, we examined the abundance of dominant Symbiodinium types associated with the coral Pocillopora verrucosa, and measured Symbiodinium physiological characteristics (i.e. photosynthetic processes, cell density, pigmentation, and protein composition) along the latitudinal gradient of the Red Sea in summer and winter. Despite the strong environmental gradients from north to south, our results demonstrate that Symbiodinium microadriaticum (type A1) was the predominant species in P. verrucosa along the latitudinal gradient. Furthermore, measured physiological characteristics were found to vary more with prevailing seasonal environmental conditions than with region-specific differences, although the measured environmental parameters displayed much higher spatial than temporal variability. We conclude that our findings might present the result of long-term acclimatization or adaptation of S. microadriaticum to regionally specific conditions within the Red Sea. Of additional note, high nutrients in the South correlated with high zooxanthellae density indicating a compensation for a temperature-driven loss of photosynthetic

  7. Crónica, épica y novela: La Historia verdadera de la conquista de la Nueva España y "El mundo nuevo" de Terra Nostra

    Directory of Open Access Journals (Sweden)

    Verónica Cortínez

    2016-04-01

    Full Text Available En este trabajo me propongo demostrar cómo el verdadero modelo genérico de "El mundo nuevo" (segunda parte de Terra Nostra es la Historia verdadera de la conquista de la Nueva España de Bernal Díaz del Castillo. Este texto presenta una vacilación contraria al espíritu épico de las demás crónicas de Indias que la convierte en "la primera novela hispanoamericana".   This article intends to show how the true generic model of "El mundo nuevo" (the second part of Terra Nostra is the Historia verdadera de la conquista de la Nueva España, by Bernal Díaz del Castillo. This text contains a vacillation contrary to the epic spirit of the other Crónicas de Indias which makes it the "first Spanish-American novel". In this novel, Fuentes exploits this fissure in order to give a new version of the conquest.

  8. Rapid biosynthesis of silver nanoparticles using Crotalaria verrucosa leaves against the dengue vector Aedes aegypti: what happens around? An analysis of dragonfly predatory behaviour after exposure at ultra-low doses.

    Science.gov (United States)

    Murugan, Kadarkarai; Sanoopa, C P; Madhiyazhagan, Pari; Dinesh, Devakumar; Subramaniam, Jayapal; Panneerselvam, Chellasamy; Roni, Mathath; Suresh, Udaiyan; Nicoletti, Marcello; Alarfaj, Abdullah A; Munusamy, Murugan A; Higuchi, Akon; Kumar, Suresh; Perumalsamy, Haribalan; Ahn, Young-Joon; Benelli, Giovanni

    2016-01-01

    Aedes aegypti is a primary vector of dengue, a mosquito-borne viral disease infecting 50-100 million people every year. Here, we biosynthesised mosquitocidal silver nanoparticles (AgNP) using the aqueous leaf extract of Crotalaria verrucosa. The green synthesis of AgNP was studied by UV-vis spectroscopy, SEM, EDX and FTIR. C. verrucosa-synthesised AgNPs were toxic against A. aegypti larvae and pupae. LC50 of AgNP ranged from 3.496 ppm (I instar larvae) to 17.700 ppm (pupae). Furthermore, we evaluated the predatory efficiency of dragonfly nymphs, Brachydiplax sobrina, against II and III instar larvae of A. aegypti in an aquatic environment contaminated with ultra-low doses of AgNP. Under standard laboratory conditions, predation after 24 h was 87.5% (II) and 54.7% (III). In an AgNP-contaminated environment, predation was 91 and 75.5%, respectively. Overall, C. verrucosa-synthesised AgNP could be employed at ultra-low doses to reduce larval population of dengue vectors enhancing predation rates of dragonfly nymphs.

  9. Double autologous lymph node transplantation (ALNT) at the level of the knee and inguinal region for advanced lymphoedema of the lower limb (elephantiasis).

    Science.gov (United States)

    Gómez Martín, C; Murillo, C; Maldonado, A A; Cristóbal, L; Fernández-Cañamaque, J L

    2014-02-01

    Primary lower-limb lymphoedema is a chronic, progressive and debilitating condition with a difficult management, especially in advanced cases (elephantiasis). Recently, autologous lymph node transplantation (ALNT) appears to be a promising treatment for extremity lymphoedema. A case of a double ALNT for an advanced primary lower-limb lymphoedema is here reported: a contralateral inguinal lymph node flap was transferred to the knee and, in a second surgery, a thoracic lymph node flap was transplanted to the inguinal region. Clinical outcomes at 5 months postoperatively are very satisfactory with reduction in limb circumferences and improvement in skin quality and social impairment. Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  10. [A case of iatrogenic scrotal elephantiasis: reconstruction of the scrotal purse and the cutaneous sleeve of the penis with local skin flaps].

    Science.gov (United States)

    Masia, D-R; Castus, P; Delia, G; Casoli, V; Martine, D

    2008-02-01

    Scrotal elephantiasis is a pathology of often unknown etiology. Symptomatology is characterized by an oedematius infiltration of skin and subcutaneous tissue, hard-bound aspect and purplished color. The scrotum, the penis and the perineal area are gradually affected. This pathology is very invalidating for the patient, on functional, sexual and aesthetic aspects. The authors present the case of a 58-year-old man with an enormous scrotal mass invading the penis and drowning the testicular elements, which were impossible to palpate. The aetiology was determined by exclusion and an iatrogenic origin following the cure of bilateral inguinal hernia was retained. Resection of the scrotal mass was performed. The reconstruction of the scrotal purse and the cutaneous sleeve of the penis were carried out using local flaps of the remaining healthy skin.

  11. FAKTOR STATUS PEMBUDIDAYA, KONDISI, DAN PENGELOLAAN TAMBAK YANG BERPENGARUH TERHADAP PRODUKSI RUMPUT LAUT (Gracilaria verrucosa DI TAMBAK TANAH SULFAT MASAM KABUPATEN LUWU UTARA PROVINSI SULAWESI SELATAN

    Directory of Open Access Journals (Sweden)

    Erna Ratnawati

    2016-11-01

    Full Text Available Tambak di Kabupaten Luwu Utara umumnya tergolong tanah sulfat masam dan banyak digunakan untuk budidaya rumput laut (Gracilaria verrucosa dengan produksi yang tinggi. Oleh karena itu, dilakukan penelitian yang bertujuan untuk mengetahui faktor status pembudidaya, kondisi, dan pengelolaan tambak yang mempengaruhi produksi rumput laut. Metode penelitian yang diaplikasikan adalah metode survai untuk mendapatkan data primer dari produksi, status pembudidaya, dan pengelolaan tambak yang dilakukan melalui pengajuan kuisioner kepada responden secara terstruktur, sedangkan kondisi tambak ditentukan melalui pengamatan dan pengukuran langsung di lapangan. Sebagai peubah tidak bebas adalah produksi dan peubah bebas adalah faktor status pembudidaya yang terdiri atas 10 peubah, kondisi tambak yang terdiri atas 12 peubah, dan pengelolaan tambak yang terdiri atas 26 peubah. Analisis regresi berganda dengan peubah boneka digunakan untuk memprediksi produksi rumput laut. Hasil penelitian menunjukkan bahwa produksi aktual rata-rata rumput laut di tambak tanah sulfat masam sebesar 7.821 kg/ha/tahun dengan prediksi produksi sebesar 23.563 kg kering/ha/tahun. Produksi rumput laut dapat ditingkatkan melalui: peningkatan pengalaman pembudidaya tambak, penambahan jumlah pintu air, tambak dibuat dengan bentuk bujur sangkar atau empat persegi panjang dengan luasan tambak tidak terlalu luas serta peningkatan lama pengeringan tanah dasar tambak, padat penebaran ikan bandeng, dosis kapur dan dosis pupuk Urea, SP-36, KCl, dan Za sebagai pupuk dasar. Brackishwater pond in North Luwu Regency, generally as classified as acid sulfate soils and most of them was used for culturing seaweed (Gracilaria verrucosa with high productivity. Hence, it was conduct research that aim to know the effect of farmer status, condition, and management of pond on the seaweed production. Survey method was applied to find primary data of seaweed production, farmer status and pond management, while

  12. Assessing the effects of iron enrichment across holobiont compartments reveals reduced microbial nitrogen fixation in the Red Sea coral Pocillopora verrucosa

    KAUST Repository

    Radecker, Nils; Pogoreutz, Claudia; Ziegler, Maren; Ashok, Ananya; Barreto, Marcelle M.; Chaidez, Veronica; Grupstra, Carsten G. B.; Ng, Yi Mei; Perna, Gabriela; Aranda, Manuel; Voolstra, Christian R.

    2017-01-01

    The productivity of coral reefs in oligotrophic tropical waters is sustained by an efficient uptake and recycling of nutrients. In reef-building corals, the engineers of these ecosystems, this nutrient recycling is facilitated by a constant exchange of nutrients between the animal host and endosymbiotic photosynthetic dinoflagellates (zooxanthellae), bacteria, and other microbes. Due to the complex interactions in this so-called coral holobiont, it has proven difficult to understand the environmental limitations of productivity in corals. Among others, the micronutrient iron has been proposed to limit primary productivity due to its essential role in photosynthesis and bacterial processes. Here, we tested the effect of iron enrichment on the physiology of the coral Pocillopora verrucosa from the central Red Sea during a 12-day experiment. Contrary to previous reports, we did not see an increase in zooxanthellae population density or gross photosynthesis. Conversely, respiration rates were significantly increased, and microbial nitrogen fixation was significantly decreased. Taken together, our data suggest that iron is not a limiting factor of primary productivity in Red Sea corals. Rather, increased metabolic demands in response to iron enrichment, as evidenced by increased respiration rates, may reduce carbon (i.e., energy) availability in the coral holobiont, resulting in reduced microbial nitrogen fixation. This decrease in nitrogen supply in turn may exacerbate the limitation of other nutrients, creating a negative feedback loop. Thereby, our results highlight that the effects of iron enrichment appear to be strongly dependent on local environmental conditions and ultimately may depend on the availability of other nutrients.

  13. Concentración de clorofila a en colonias de Pocillopora verrucosa (Scleractina durante un blanqueamiento coralino en el Golfo de California, México (1997

    Directory of Open Access Journals (Sweden)

    Adrián Munguía-Vega

    1999-12-01

    Full Text Available El Niño-Southern Oscillation 1997-98 significantly elevated sea temperatures in the Gulf of California and caused widespread coral bleaching starting in july 1997. Changes in chlorphyll a concentration by unit of area (cm² among normal, discolored and totally bleached colonies of the coral Pocillopora verrucosa (=P. elegans were determined in 27 colonies collected in october, 1997 at Ensenada de Muertos, Baja California peninsula, México (24° 03’ N, by spectrophotometric determinations. Mean pigment values varied from 2.06 µg/cm2 to 1.12 µg/cm2 and 0.09 µg/cm² among normal, decolorated and totally bleached colonies, respectively, although statistically significant differences only appeared between completely bleached and normal corals. The low chlorophyll concentration of the healthy-looking ("normal" corals and the lack of differences in pigment concentrations between these and partially bleached corals, indicated that the former had actually suffered a previous loss of pigmentation and may have been recovering when sampled.

  14. Early development of zooxanthella-containing eggs of the corals Pocillopora verrucosa and P. eydouxi with special reference to the distribution of zooxanthellae.

    Science.gov (United States)

    Hirose, M; Kinzie, R A; Hidaka, M

    2000-08-01

    Some hermatypic corals spawn eggs that contain zooxanthellae. We followed development of zooxanthella-containing eggs of two such species, Pocillopora verrucosa and P. eydouxi. We also documented changes in the distribution pattern of zooxanthellae during development. Oocytes of both species took up zooxanthellae 3 to 4 days before spawning. At first, zooxanthellae were evenly distributed in oocytes, but they later moved to the hemisphere that contained the germinal vesicle. After fertilization, early cleavage events were holoblastic, progressing by furrow formation. The first cleavage furrow started at the hemisphere that contained zooxanthellae, dividing the zooxanthellate complement of the zygote about equally into the two blastomeres. The second division divided each blastomere into one zooxanthellae-rich cell and one with few zooxanthellae. With continued cell division, blastomeres containing zooxanthellae moved into the blastocoel. The blastocoel disappeared at about 5 h after the first cleavage, and the central region of the embryo was filled with cells containing either zooxanthellae or lipid droplets, forming a stereogastrula. Our results suggest that only blastomeres that had been determined to develop into gastrodermal cells receive zooxanthellae during cleavage. This determination appears to take place, at the latest, by the second cell division at the four-cell stage.

  15. Assessing the effects of iron enrichment across holobiont compartments reveals reduced microbial nitrogen fixation in the Red Sea coral Pocillopora verrucosa

    KAUST Repository

    Radecker, Nils

    2017-07-31

    The productivity of coral reefs in oligotrophic tropical waters is sustained by an efficient uptake and recycling of nutrients. In reef-building corals, the engineers of these ecosystems, this nutrient recycling is facilitated by a constant exchange of nutrients between the animal host and endosymbiotic photosynthetic dinoflagellates (zooxanthellae), bacteria, and other microbes. Due to the complex interactions in this so-called coral holobiont, it has proven difficult to understand the environmental limitations of productivity in corals. Among others, the micronutrient iron has been proposed to limit primary productivity due to its essential role in photosynthesis and bacterial processes. Here, we tested the effect of iron enrichment on the physiology of the coral Pocillopora verrucosa from the central Red Sea during a 12-day experiment. Contrary to previous reports, we did not see an increase in zooxanthellae population density or gross photosynthesis. Conversely, respiration rates were significantly increased, and microbial nitrogen fixation was significantly decreased. Taken together, our data suggest that iron is not a limiting factor of primary productivity in Red Sea corals. Rather, increased metabolic demands in response to iron enrichment, as evidenced by increased respiration rates, may reduce carbon (i.e., energy) availability in the coral holobiont, resulting in reduced microbial nitrogen fixation. This decrease in nitrogen supply in turn may exacerbate the limitation of other nutrients, creating a negative feedback loop. Thereby, our results highlight that the effects of iron enrichment appear to be strongly dependent on local environmental conditions and ultimately may depend on the availability of other nutrients.

  16. Studying the ability of mutation and selection of promising lines of Brassia Verrucosa Lindl. by gamma irradiation in combination with in vitro technique

    International Nuclear Information System (INIS)

    Le Thi Thuy Linh; Le Van Thuc; Dang Thi Dien; Han Huynh Dien; Le Thi Bich Thy

    2016-01-01

    The objective of this study was to induce mutation in Warty Brassia (Brassia verrucosa Lindl.) through in vitro mutagenesis by treating the bud clusters with gamma irradiation, aiming to select the valuable varieties of Warty Brassia. The following contents were conducted: detecting of genetic polymorphism of the variants by applying RAPD analysis; evaluating the growth of variation forms of Warty Brassia obtaining after irradiation in the nursery stage; selecting desired variations. The results revealed that 9 variants were examined genetic diversity, 8 variants there were genetic differences among 8 variants and original variety. There were differences in the growth potential among morphological variants under nursery condition. The mutants having large pseudobulb, dark green leaves and the mutants having pseudobulb round in shape, short leaves promise to develop mutants strains. Types of mutation were selected and multiply rapidly from generation M_1V_1 - M_1V_3, they retained 100% morphological features of their parents. The study is being conducting to assess the flower color and shape of the mutants derived from Warty Brassia. (author)

  17. PEUBAH KUALITAS AIR YANG MEMPENGARUHI PERTUMBUHAN RUMPUT LAUT (Gracilaria verrucosa DI TAMBAK TANAH SULFAT MASAM KECAMATAN ANGKONA KABUPATEN LUWU TIMUR PROVINSI SULAWESI SELATAN

    Directory of Open Access Journals (Sweden)

    Akhmad Mustafa

    2009-04-01

    Full Text Available Rumput laut (Gracilaria verrucosa telah dibudidayakan di tambak tanah sulfat masam dengan kualitas dan kuantitas produksi yang relatif tinggi. Oleh karena itu, dilakukan penelitian yang bertujuan untuk mengetahui peubah kualitas air yang mempengaruhi laju pertumbuhan rumput laut di tambak tanah sulfat masam Kecamatan Angkona Kabupaten Luwu Timur Provinsi Sulawesi Selatan. Pemeliharaan rumput laut dilakukan di 30 petak tambak  terpilih selama 6 minggu. Bibit rumput laut dengan bobot 100 g basah ditebar dalam hapa berukuran 1,0 m x 1,0 m x 1,2 m. Peubah tidak bebas yang diamati adalah laju pertumbuhan relatif, sedangkan peubah bebas adalah peubah kualitas air yang meliputi: intensitas cahaya, salinitas, suhu, pH, karbondioksida, nitrat, amonium, fosfat, dan besi. Analisis regresi berganda digunakan untuk menentukan peubah bebas yang dapat digunakan untuk memprediksi peubah tidak bebas. Hasil penelitian menunjukkan bahwa laju pertumbuhan relatif rumput laut di tambak tanah sulfat masam berkisar antara 1,52% dan 3,63%/hari dengan rata-rata 2,88% ± 0,56%/hari. Di antara 9 peubah kualitas air yang diamati ternyata hanya 5 peubah kualitas air yaitu: nitrat, salinitas, amonium, besi, dan fosfat yang mempengaruhi pertumbuhan rumput laut secara nyata. Untuk meningkatkan pertumbuhan rumput laut di tambak tanah sulfat masam Kecamatan Angkona Kabupaten Luwu Timur dapat dilakukan dengan pemberian pupuk yang mengandung nitrogen untuk meningkatkan kandungan amonium dan nitrat serta pemberian pupuk yang mengandung fosfor untuk meningkatkan kandungan fosfat sampai pada nilai tertentu, melakukan remediasi untuk menurunkan kandungan besi serta memelihara rumput laut pada salinitas air yang lebih tinggi, tetapi tidak melebihi 30 ppt. Seaweed (Gracilaria verrucosa has been cultivated in acid sulfate soil-affected ponds with relatively high quality and quantity of seaweed production. A research has been conducted to study water quality variables that influence the

  18. Osteoid osteoma: our experience using radio-frequency (RF) treatment; L'osteoma osteoide: nostra esperienza nel trattamento mediante radiofrequenza (RF)

    Energy Technology Data Exchange (ETDEWEB)

    Mastrantuono, Donato; Martorano, Domenico; Verna, Valter; Mancini, Andrea; Faletti, Carlo [U.O.A. di Radiologia Diagnostica C.T.O., Torino (Italy). Dipartimento di Diagnostica per Immagini

    2005-03-01

    clinical results indicate a 100% success rate with complete remission of symptoms and no relapses having been reported at the time of writing for those patients who have arrived at the two year follow up (4 out of 21) [Italian] Scopo: La finalita' del nostro lavoro e' presentare i risultati ottenuti nel trattamento mediante RF dell'osteoma osteoide utilizzando una tecnica a minima invasivita' messa a punto dalla nostra equipe, alla luce del secondo anno di attivita'. Materiale e metodi: Da Gennaio 2001 ad Aprile 2003 sono stati trattati ventuno pazienti affetti da osteoma osteoide (15 maschi e 6 femmine d'eta' compresa tra 13 e 34 anni). Le lesioni erano localizzate 1 al bacino, 12 al femore (terzo prossimale e medio della diafisi), 3 al terzo prossimale diafissario di tibia, 3 al piede e 2 al terzo prossimale diafissario di omero. Tutti i pazienti sono stati sottoposti a radiografia, scintigrafia e TC. All'inizio della procedura, con l'ausilio della TC, viene fissato sul corticale un filo di Kirshner (f-K), di calibro appena superiore a quello dell'ago-elettrodo (17 G), posizionato manualmente allo zenith della zona bersaglio; utilizzando un trapano ortopedico, il f-K viene introdotto sino al nidus. Sulla guida del f-K si fa procedere un introduttore, da noi appositamente studiato e realizzato al fine di non perdere l'accesso al nidus nella fase di scambio tra f-K/ago-elettrodo, sul quale, rimosso il filo d'acciaio, si posiziona l'ago-elettrodo nella lesione. La temperatura raggiunta dalla punta esposta dell'ago-elettrodo e' di 90{sup o} C; la durata dell'ipertermia e' in media di sei minuti. Al termine viene effettuata una scansione di controllo con misurazione della densita' nella sede di trattamento: tale misurazione e' utilizzata come indice di evoluzione del processo riparativo nel follow-up. Risultati: Nel corso delle procedure effettuate non abbiamo avuto complicanze

  19. Studying the ability of mutation and selection of promising lines of Brassia verrucosa Lindl. by gamma Irradiation in combination with In-Vitro technique

    International Nuclear Information System (INIS)

    Le Thi Thuy Linh; Le Van Thuc; Dang Thi Dien; Han Huynh Dien; Le Thi Bich Thy

    2015-01-01

    Mutation research by gamma irradiation is an effective technique in producing new plant breeding. In this study, we optimized some elements on the propagation process of Warty Brassia (Brassia verrucosa Lindl.) in vitro; determination of lethal dose (LD50) of Warty Brassia bud clusters in vitro; initial evaluating of gamma irradiation effects on the morphology of Warty Brassia in vitro. The results showed that, the appropriate medium for meristem-tip culture was on VW medium (Vacin and Went, 1949) containing 1 g/l activated charcoal (AC), 10% coconut water (CW), 50 g/l potato and 20 g/l sucrose; medium for in vitro shoot multiplication was on VW medium supplemented with 0.5 mg/l NAA, 0.3 mg/l BA, 1 g/l AC, 10% CW, 50 g/l potato and 20 g/l sucrose; medium for in vitro root induction was on VW medium supplemented with 0.5 mg/l NAA, 1 g/l AC, 10% CW, 50 g/l potato and 20 g/l sucrose. The plantlets were acclimatized and transplanted to 50% sphagnum moss and 50% coconut fiber, the survival rate was 94.7%; the LD50 values were in the range of 40 - 50 Gy; the stimulation dose was 10 Gy; the highest variation rate was on the dose of 40 Gy; the absolute lethal dose was 80 Gy. 6 variations of Warty Brassia in vitro were obtained including the variant of morphology, structure and diameter of pseudo-bulb were very difference comparing to control. The following study are evaluating of the growth and the phenotypic changing of potential variant types of Warty Brassia in green house. (author)

  20. Carcinoma espinocelular em leucoplasia verrucosa proliferativa: relato de caso e revisão da literatura = Squamous cell carcinoma in proliferative verrucous leukoplakia: report of a case and review of the literature

    Directory of Open Access Journals (Sweden)

    Ramalho, Luciana Maria Pedreira

    2007-01-01

    Full Text Available A Leucoplasia Verrucosa Proliferativa (LVP é uma lesão cancerizável caracterizada por comportamento biológico mais agressivo e maior risco de malignização que as leucoplasias bucais. O diagnóstico da LVP deve ser feito pela combinação de achados clínicos e microscópicos e o acompanhamento dos pacientes deve ser rigoroso envolvendo a remoção de fatores de risco como o tabaco e o álcool e biópsias de controle, que podem ser realizadas quando ocorrerem mudanças nos sinais e sintomas. Este trabalho revisa a literatura sobre LVP e relata um caso de carcinoma espinocelular originado de leucoplasia verrucosa proliferativa, enfatizando os aspectos clínicos e histopatológico bem como a importância do acompanhamento rigoroso do paciente e de exames complementares como o azul de toluidina

  1. Helminthological screening of free-ranging grey brocket deer Mazama gouazoubira Fischer, 1817 (Cervidae: Odocoileini from Brazilian Pantanal wetlands, with considerations on Pygarginema verrucosa (Molin, 1860 Kadenatzii, 1948 (Spirocercidae: Ascaropsinae

    Directory of Open Access Journals (Sweden)

    EG. Lux Hoppe

    Full Text Available The Brazilian Pantanal wetlands are a unique ecosystem with a faunistic composition similar to that of the adjacent biomes but in higher densities. The early establishment of domestic cattle husbandry in that area introduced pathogens that may influence the indigenous Pantanalian fauna. In this paper, the authors describe the helminthfauna of ten free-ranging adult Mazama gouazoubira from the Paiaguás sub-region, along with the descriptors of infection. Morphological description of Pygarginema verrucosa is supplied, with comments on other species of this genus. The helminth species found are similar to domestic cattle helminthfauna of the same physiographic region, suggesting an adaptation of bovine parasites to this host.

  2. Helminthological screening of free-ranging grey brocket deer Mazama gouazoubira Fischer, 1817 (Cervidae: Odocoileini from Brazilian Pantanal wetlands, with considerations on Pygarginema verrucosa (Molin, 1860 Kadenatzii, 1948 (Spirocercidae: Ascaropsinae Avaliação helmintológica de veados-catingueiros Mazama gouazoubira Fischer, 1817 (Cervidae: Odocoileini de vida livre, procedentes do Pantanal brasileiro, com considerações sobre Pygarginema verrucosa (Molin, 1860 Kadenatzii, 1948 (Spirocercidae: Ascaropsinae

    Directory of Open Access Journals (Sweden)

    EG. Lux Hoppe

    2010-05-01

    Full Text Available The Brazilian Pantanal wetlands are a unique ecosystem with a faunistic composition similar to that of the adjacent biomes but in higher densities. The early establishment of domestic cattle husbandry in that area introduced pathogens that may influence the indigenous Pantanalian fauna. In this paper, the authors describe the helminthfauna of ten free-ranging adult Mazama gouazoubira from the Paiaguás sub-region, along with the descriptors of infection. Morphological description of Pygarginema verrucosa is supplied, with comments on other species of this genus. The helminth species found are similar to domestic cattle helminthfauna of the same physiographic region, suggesting an adaptation of bovine parasites to this host.O Pantanal brasileiro é um ecossistema único, com composição faunística semelhante à dos biomas adjacentes, mas com densidades superiores. O gado introduzido na região pode ter carreado patógenos nesse ecossistema que podem, de alguma forma, influenciar a fauna local. Neste artigo, é descrita a helmintofauna de dez indivíduos adultos de Mazama gouazoubira provenientes da sub-região de Paiaguás, juntamente com os indicadores de infecção helmíntica. Ainda, são fornecidas informações sobre a morfologia de Pygarginema verrucosa, com comentários sobre outras espécies deste gênero. As espécies de helmintos diagnosticadas são semelhantes àquelas encontradas em bovinos da mesma região, sugerindo adaptação destas no hospedeiro estudado.

  3. Role of Spiral and Multislice Computed Tomography in the evaluation of traumatic and spontaneous oesophageal perforation. Our experience; Ruolo della Tomografia Computerizzata Spirale e Multistrato nello studio delle lesioni traumatiche e spontanee dell'esofago: nostra esperienza

    Energy Technology Data Exchange (ETDEWEB)

    De Lutio di Castelguidone, Elisabetta; Pinto, Antonio; Merola, Stefanella; Stavolo, Ciro; Romano, Luigia [Azienda Ospedaliera di Rilievo Nazionale A. Cardarelli, Napoli (Italy). Dipartimento di Diagnostica per Immagini

    2005-03-01

    oesophageal perforation, CT showed the presence of a intramural haematoma in one case, oesophageal fluid distension with gas and a small peri-oesophageal fluid effusion (Mallory-Weiss syndrome) in another, and oesophageal rapture (Boerhaave syndrome) in the last case. Conclusions: Our experience shows that in patients with suspected traumatic and spontaneous oesophageal perforation, standard cervical and chest radiography may suggest a suspected oesophageal perforation in only a small proportion of cases, whereas oral contrast oesophagography has a higher sensitivity. Through the careful analysis of suggestive and specific signs of oesophageal perforation, a correct CT examination enables an accurate and timely diagnosis which significantly affects prognosis and provides valuable indications for treatment. [Italian] Scopo: Presentare la nostra esperienza relativa al ruolo della TC nello studio delle perforazioni traumatiche e spontanee dell'esofago. Materiale e metodi: Da marzo 2001 a maggio 2003 sono giunti alla nostra osservazione 12 pazienti (7 di sesso maschile, 5 di sesso femminile, di eta' compresa tra 25 e 66 anni, eta' media 43,5) con sospetta lesione esofagea da incidente stradale (in 4 casi), ferita d'arma bianca (un caso), post-intubazione (2 casi), da indigestione di corpo estraneo (2 casi) e di tipo spontaneo (3 casi). Cinque pazienti praticavano l'esame standard del torace e della regione cervicale. In 2 pazienti con sospetta indigestione di corpo estraneo veniva somministrato gastrografin per os. In tutti i 12 casi veniva eseguito l'esame TC del collo-torace-addome senza e con mdc ev e con mdc idrosolubile per os in 4 casi. Risultati: Nei 5 pazienti con trauma cervico-toracico-addominale l'indagine TC evidenziava oltre a lesioni traumatiche pleuro-parenchimali (pneumotorace, versamento pleurico ed enfisema sottocutaneo) anche reperti suggestivi di perforazione esofagea: aria mediastinica in sede periesofagea (5 casi), fluido

  4. Cutaneous tuberculosis, tuberculosis verrucosa cutis

    Directory of Open Access Journals (Sweden)

    Nilamani Mohanty

    2014-01-01

    Full Text Available Cutaneous tuberculosis because of its variability in presentation, wider differential diagnosis, and difficulty in obtaining microbiological confirmation continues to be the most challenging to diagnose for dermatologists in developing countries. Despite the evolution of sophisticated techniques such as polymerase chain reaction (PCR and enzyme-linked-immunosorbent serologic assay (ELISA, the sensitivity of new methods are not better than the isolation of Mycobacterium tuberculosum in culture. Even in the 21 st century, we rely on methods as old as the intradermal reaction purified protein derivative standard test and therapeutic trials, as diagnostic tools. We describe a case which has been diagnosed and treated as eczema by renowned physicians for 2 years. Incisional biopsy showed the presence of well-defined granulomas and ZN staining of the biopsy specimen showed the presence of acid fast bacilli; a trial of ATT (antitubercular therapy for 6 months lead to permanent cure of the lesion.

  5. documents Nostra aetate and Lumen gentium7

    African Journals Online (AJOL)

    Test

    non-Christian cultures became known to the West through their moral and spiritual .... That is the reason why academic terms such as 'problem' were avoided ..... 2007, Inter-religious dialogue: Urgent challenge and theological Land-Mine, ...

  6. Provocative Opinion: Elephantiasis of the Textbook.

    Science.gov (United States)

    Kerber, Robert C.

    1988-01-01

    Addresses the growing size of college organic chemistry textbooks. Notes that at the current rate of growth, average textbooks will be 1544 pages long in year 2000. Suggests methods to reduce textbook size. (ML)

  7. Podoconiosis, non-filarial elephantiasis, and lymphology.

    Science.gov (United States)

    Davey, G

    2010-12-01

    Several recent reviews of podoconiosis already exist in journals and on public access websites. After briefly covering the historical and epidemiological background, this narrative review will therefore attempt explicitly to link podoconiosis with lymphology, examining gaps in what is known of pathogenesis and identifying the areas of research in which input from lymphologists is most required. Finally, prevention and treatment will be described and the need for operational research to optimize community-based interventions outlined.

  8. Elephantine but not elephantiasis: Subcutaneous zygomycosis.

    Science.gov (United States)

    Girish, Meenakshi; Arora, Amit; Bhalla, Lucky; Salodkar, Atul

    2011-09-01

    Subcutaneous zygomycosis is an unusual disorder caused by a rare fungus, Basidiobolus ranarum. We report this entity in a 4- yr- old boy. Biopsy showed the Splendore Hoeppli phenomenon and the culture yielded Basidiobolus ranarum. The child responded to saturated solution of potassium iodide within 1 month of starting treatment.

  9. Smart objects: come il digitale organizza la nostra vita

    Directory of Open Access Journals (Sweden)

    Emanuele Crescimanno

    2014-06-01

    Full Text Available Computer, tablet, smartphone are the most important everyday objects in our life because we made experiences by them; they run due to their software: so it is necessary to understand it, his form, his design and his tradeoffs to understand the role of these objects and the possibilities of a conscious use of them.

  10. Metabolic rates and tissue composition of the coral Pocillopora verrucosa over 12 latitudes in the Red Sea characterized by strong temperature and nutrient gradient, supplement to: Sawall, Yvonne; Al-Sofyani, A; Hohn, S; Banguera-Hinestroza, E; Voolstra, Christian R; Wahl, Martin (2015): Extensive phenotypic plasticity of a Red Sea coral over a strong latitudinal temperature gradient suggests limited acclimatization potential to warming. Scientific Reports, 5, 8940

    KAUST Repository

    Sawall, Yvonne

    2015-01-01

    Global warming was reported to cause growth reductions in tropical shallow water corals in both, cooler and warmer, regions of the coral species range. This suggests regional adaptation with less heat-tolerant populations in cooler and more thermo-tolerant populations in warmer regions. Here, we investigated seasonal changes in the in situ metabolic performance of the widely distributed hermatypic coral Pocillopora verrucosa along 12 degrees latitudes featuring a steep temperature gradient between the northern (28.5 degrees N, 21-27 degrees C) and southern (16.5 degrees N, 28-33 degrees C) reaches of the Red Sea. Surprisingly, we found little indication for regional adaptation, but strong indications for high phenotypic plasticity: Calcification rates in two seasons (winter, summer) were found to be highest at 28-29 degrees C throughout all populations independent of their geographic location. Mucus release increased with temperature and nutrient supply, both being highest in the south. Genetic characterization of the coral host revealed low inter-regional variation and differences in the Symbiodinium clade composition only at the most northern and most southern region. This suggests variable acclimatization potential to ocean warming of coral populations across the Red Sea: high acclimatization potential in northern populations, but limited ability to cope with ocean warming in southern populations already existing at the upper thermal margin for corals

  11. Podoconiosis and endemic non-filarial tropical elephantiasis ...

    African Journals Online (AJOL)

    2013-07-05

    Jul 5, 2013 ... of the foot is noted, often over the rst or second web space. Constant scratching ... to deep oedema between metatarsal heads; (b) block toes – the swelling of the .... forums and community leader meetings to develop a locally ...

  12. Podoconiosis and endemic non-filarial tropical elephantiasis ...

    African Journals Online (AJOL)

    2013-07-05

    Jul 5, 2013 ... height for prolonged periods leads to improved venous and lymphatic return and considerable reduction in limb size, especially in the water bag-type ... talks within communities, e.g. at religious gatherings and in schools. Other Ethiopian podo treatment projects have set up patient forums and community ...

  13. Il mondo secondo la fisica quantistica segreti e meraviglie della scienza che sta cambiando la nostra vita

    CERN Document Server

    Fracas, Fabio

    2017-01-01

    Questo libro è un'avventura esclusiva e affascinante. Un viaggio, anche nel tempo, alla scoperta di qualcosa di nuovo e di straordinario: la Fisica Quantistica, nelle sue logiche, nelle sue potenzialità, nelle sue applicazioni e nei suoi possibili sviluppi. All'interno del volume vengono ricostruiti passo dopo passo i momenti fondamentali del pensiero quantistico, le questioni su cui si sono interrogati i più grandi scienziati degli ultimi decenni, e i diversi contesti nei quali si sono evoluti i principali modelli della Meccanica Quantistica. Sullo sfondo delle ricerche più attuali - come per esempio quella sulle onde gravitazionali che ha portato al Nobel per la Fisica 2017 -, vengono indagati anche i rapporti esistenti fra Fisica Quantistica, Relatività Einsteiniana e Teoria delle Stringhe. Inoltre, fra i tanti temi trattati nelle sue pagine, trovano spazio persino le incredibili ricadute che gli studi sulla Fisica Quantistica stanno avendo negli ambiti della medicina e delle ricerche sul cervello e s...

  14. Diavolo di una particella perchè il bosone di Higgs cambierà la nostra vita

    CERN Document Server

    Menasce, Dario

    2013-01-01

    Lo scienziato del Cern Dario Menasce ha partecipato direttamente agli esperimenti che hanno condotto alla scoperta del Bosone di Higgs, ma , prima di condurre il lettore all'interno dell'LHC e dei suoi misteri, con coinvolgimento e grande serietà guida il lettore attraverso i momenti più importanti delle ricerche della fisica tramite l'intervento dei grandi scienziati del passato e del presente, che hanno infine permesso di arrivare a definire il Modello Standard delle particelle, il primo passo verso l'ipotetica Teoria del Tutto. Un testo molto utile per chi vuole sondare il mondo dell'ultrasottile, che riprendo in più occasioni anche come manuale di consultazione e approfondimento.

  15. On some winning strategies for the Iterated Prisoner's Dilemma or Mr. Nice Guy and the Cosa Nostra

    OpenAIRE

    Slany, Wolfgang; Kienreich, Wolfgang

    2006-01-01

    We submitted two kinds of strategies to the iterated prisoner's dilemma (IPD) competitions organized by Graham Kendall, Paul Darwen and Xin Yao in 2004 and 2005. Our strategies performed exceedingly well in both years. One type is an intelligent and optimistic enhanced version of the well known TitForTat strategy which we named OmegaTitForTat. It recognizes common behaviour patterns and detects and recovers from repairable mutual defect deadlock situations, otherwise behaving much like TitFor...

  16. Idiopathic elephantiasis gingivae with generalized aggressive periodontitis: A rare case report and literature review

    Directory of Open Access Journals (Sweden)

    Shahabe Saquib

    2015-01-01

    Full Text Available Idiopathic gingival enlargement is a rare entity with unknown etiology. Diagnosis of the case is of utmost important for the comprehensive treatment planning. In the present case, the clinical presentation and intervention of the patient reported with diffuse firm and nonedematous enlargement, disfigurement of the face, difficulty in speech, and mastication. Periodontal status showed severe attachment loss with minimal local factors, which is typical for generalized aggressive periodontitis. Timely detection of the disease with the critical planning of treatment and routine follow-up with good oral hygiene practices are good enough to combat the morbidity of this disease.

  17. Rahvusvaheline muinsuskaitseauhind Eestisse: maailma lennundusajaloo suurimad angaarid väikses Eestis / Helle Solnask

    Index Scriptorium Estoniae

    Solnask, Helle

    2014-01-01

    Muinsuskaitseorganisatsioonist Europa Nostra. Europa Nostra muinsuskaitseauhindadest. 2013. aastal osutus üheks 15-st laureaadist I kategoorias (restaureeerimine/konserveerimine) Tallinna vesilennukite angaaride taastamine ning kohandamine kaasaegseks meremuuseumiks

  18. 8 Allergenic Composition of Polymerized Allergen Extracts of Betula verrucosa, Dermatophagoides Pteronyssinus and Phleum Pratense

    OpenAIRE

    Fernandez-Caldas, Enrique; Cases, Barbara; Tudela, Jose Ignacio; Fernandez, Eva Abel; Casanovas, Miguel; Subiza, Jose Luis

    2012-01-01

    Background Allergoids have been successfully used in the treatment of respiratory allergic diseases. They are modified allergen extracts that allow the administration of high allergen doses, due to their reduced IgE binding capacity.They maintain allergen-specific T-cell recognition. Since they are native allergen extracts that have been polymerized with glutaraldehyde, identification of the allergenic molecules requires more complicated methods. The aim of the study was to determine the qual...

  19. Bartonellosis en Colombia, bartonellosis de guáitara ó fiebre verrucosa del guáitara

    Directory of Open Access Journals (Sweden)

    Luis Patiño Camargo

    1939-04-01

    Full Text Available Desde principios de 1936 las autoridades de Nariño venían seriamente preocupadas por una mortífera enfermedad epidémica aparecida al Norte en vertientes de juanambu y del rio Mayo, enfermedad que de improviso se presentó en el Guáitara con gran virulencia. El médico doctor Max Llorente, Gobernador entonces del Departamento, inspeccionó con el Director de Higiene la zona invadida, y a su regreso a Pasto conferencio con el Colegio Médico. En la reunión se acogió el diagnostico de paludismo agudo pernicioso. Como resultado se organizó una comisión de tratamiento encabezada por un médico, y se situó en Ancuya. Por esos días el Departamento Nacional de Higiene envió un ingeniero sanitario, quien recorrió las comarcas atacadas y rindió un informe.

  20. Development and testing of a de novo clinical staging system for podoconiosis (endemic non-filarial elephantiasis).

    Science.gov (United States)

    Tekola, Fasil; Ayele, Zewdu; Mariam, Dereje Haile; Fuller, Claire; Davey, Gail

    2008-10-01

    To develop and test a robust clinical staging system for podoconiosis, a geochemical disease in individuals exposed to red clay soil. We adapted the Dreyer system for staging filarial lymphoedema and tested it in four re-iterative field tests conducted in an area of high-podoconiosis prevalence in Southern Ethiopia. The system has five stages according to proximal spread of disease and presence of dermal nodules, ridges and bands. We measured the 1-week repeatability and the inter-observer agreement of the final staging system. The five-stage system is readily understood by community workers with little health training. Kappa for 1-week repeatability was 0.88 (95% CI 0.80-0.96), for agreement between health professionals was 0.71 (95% CI 0.60-0.82), while that between health professionals and community podoconiosis agents without formal health training averaged 0.64 (95% CI 0.52-0.78). This simple staging system with good inter-observer agreement and repeatability can assist in the management and further study of podoconiosis.

  1. Taking the Bite Out of Vector-Borne Diseases

    Science.gov (United States)

    ... with implications for how diseases spread. Disease Control Elephantiasis caused by parasitic worms (top) affects more than ... inflammatory responses that lead to river blindness and elephantiasis. In an ironic twist, researchers are actually using ...

  2. Lymphatic Filariasis: Frequently Asked Questions (FAQs)

    Science.gov (United States)

    ... Evaluation and Treatment Care of Patients with Lymphedema, Elephantiasis or Hydrocele Publications Additional Resources Get Email Updates ... and thickening of the skin, which is called elephantiasis. Many of these bacterial infections can be prevented ...

  3. Lymphatic Filariasis

    Science.gov (United States)

    ... Evaluation and Treatment Care of Patients with Lymphedema, Elephantiasis or Hydrocele Publications Additional Resources Get Email Updates ... with the disease can suffer from lymphedema and elephantiasis and in men, swelling of the scrotum, called ...

  4. Large scale patterns of antimicrofouling defenses in the hard coral Pocillopora verrucosa in an environmental gradient along the Saudi Arabian coast of the Red Sea.

    Science.gov (United States)

    Wahl, Martin; Al Sofyani, Abdulmohsin; Saha, Mahasweta; Kruse, Inken; Lenz, Mark; Sawall, Yvonne

    2014-01-01

    Large scale patterns of ecologically relevant traits may help identify drivers of their variability and conditions beneficial or adverse to the expression of these traits. Antimicrofouling defenses in scleractinian corals regulate the establishment of the associated biofilm as well as the risks of infection. The Saudi Arabian Red Sea coast features a pronounced thermal and nutritional gradient including regions and seasons with potentially stressful conditions to corals. Assessing the patterns of antimicrofouling defenses across the Red Sea may hint at the susceptibility of corals to global change. We investigated microfouling pressure as well as the relative strength of 2 alternative antimicrofouling defenses (chemical antisettlement activity, mucus release) along the pronounced environmental gradient along the Saudi Arabian Red Sea coast in 2 successive years. Microfouling pressure was exceptionally low along most of the coast but sharply increased at the southernmost sites. Mucus release correlated with temperature. Chemical defense tended to anti-correlate with mucus release. As a result, the combined action of mucus release and chemical antimicrofouling defense seemed to warrant sufficient defense against microbes along the entire coast. In the future, however, we expect enhanced energetic strain on corals when warming and/or eutrophication lead to higher bacterial fouling pressure and a shift towards putatively more costly defense by mucus release.

  5. Adaptation and impairment of DNA repair function in pollen of Betula verrucosa and seeds of Oenothera biennis from differently radionuclide-contaminated sites of Chernobyl.

    Science.gov (United States)

    Boubriak, I I; Grodzinsky, D M; Polischuk, V P; Naumenko, V D; Gushcha, N P; Micheev, A N; McCready, S J; Osborne, D J

    2008-01-01

    The plants that have remained in the contaminated areas around Chernobyl since 1986 encapsulate the effects of radiation. Such plants are chronically exposed to radionuclides that they have accumulated internally as well as to alpha-, beta- and gamma-emitting radionuclides from external sources and from the soil. This radiation leads to genetic damage that can be countered by DNA repair systems. The objective of this study is to follow DNA repair and adaptation in haploid cells (birch pollen) and diploid cells (seed embryos of the evening primrose) from plants that have been growing in situ in different radionuclide fall-out sites in monitored regions surrounding the Chernobyl explosion of 1986. Radionuclide levels in soil were detected using gamma-spectroscopy and radiochemistry. DNA repair assays included measurement of unscheduled DNA synthesis, electrophoretic determination of single-strand DNA breaks and image analysis of rDNA repeats after repair intervals. Nucleosome levels were established using an ELISA kit. Birch pollen collected in 1987 failed to perform unscheduled DNA synthesis, but pollen at gamma/beta-emitter sites has now recovered this ability. At a site with high levels of combined alpha- and gamma/beta-emitters, pollen still exhibits hidden damage, as shown by reduced unscheduled DNA synthesis and failure to repair lesions in rDNA repeats properly. Evening primrose seed embryos generated on plants at the same gamma/beta-emitter sites now show an improved DNA repair capacity and ability to germinate under abiotic stresses (salinity and accelerated ageing). Again those from combined alpha- and gamma/beta-contaminated site do not show this improvement. Chronic irradiation at gamma/beta-emitter sites has provided opportunities for plant cells (both pollen and embryo cells) to adapt to ionizing irradiation and other environmental stresses. This may be explained by facilitation of DNA repair function.

  6. Elephantiasis, elastin, and chronic wound healing: 19th century and contemporary viewpoints relevant to hypotheses concerning lymphedema, leprosy, erysipelas, and psoriasis--review and reflections.

    Science.gov (United States)

    Ryan, T J

    2009-03-01

    Both wound healing and lymphedema have fibrosis of the skin in common. They also share destruction of elastin by elastases from neutrophils as a significant feature. These are not new observations, and the writings of Unna and Kaposi are recalled. The contemporary observations on elastin by Gerli and his team are discussed in the light of these much earlier opinions.

  7. How 'The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks' has underpinned progress in podoconiosis research.

    Science.gov (United States)

    Deribe, Kebede; Davey, Gail

    2014-09-01

    We demonstrate how an article from the Transactions of the Royal Society of Tropical Medicine & Hygiene archive has triggered two important series of studies into the aetiology and distribution of podoconiosis, 30 years after first publication of the article. It indicates the value of becoming familiar with hypotheses raised by earlier investigators and of direct use of historical data in understanding trends in disease distribution. © The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  8. Hästi restaureeritud raekoda sai Euroopast kõrge tunnustuse / Askur Alas

    Index Scriptorium Estoniae

    Alas, Askur, 1973-

    2006-01-01

    Tallinna raekoda sai Euroopa Liidu ja Euroopa pärandkultuuri organisatsiooni Europa Nostra kultuuripärandi medali. Europa Nostra nõukogu liikme Karin Hallas-Murula sõnul arvestatakse auhindade jagamisel nii mälestise säilitamist kui ka kasutamist tänapäeval. Mainekas auhind on tunnustus Teddy Böcklerile, kellele raekoja restaureerimine oli elutööks. Lisatud Europa Nostra peapreemiad

  9. Euroopa aadel armastab ajalugu / Karin Hallas-Murula

    Index Scriptorium Estoniae

    Hallas-Murula, Karin, 1957-

    2004-01-01

    Organisatsioonist Europa Nostra, mille nõukokku valiti 2003. a. Karin Hallas. Tänavuste Europa Nostra preemiate kätteandmisest Münchenis ja objektidest, mille hulgas oli Leedu endise historitsistliku valitsushoone renoveerimine Kaunases (nüüd ülikooli rektoraat). Uue ilme saanud Tallinna raekoja esitamisest kandidaadiks

  10. Itaalias vangistati peaprokuröri tappa tahtnud mafioosod / Ülle Toode

    Index Scriptorium Estoniae

    Toode, Ülle, 1969-

    2005-01-01

    Sitsiilias vahistati ligi poolsada maffiaorganisatsiooni Cosa Nostra väidetavat liiget. Politseini oli jõudnud info, et mafioosod kavatsevad lähiajal tappa Palermo peaprokuröri Pietro Grasso, tabamata on Cosa Nostra juht. Lisa: Kohtunik üksi sõjas maffia vastu

  11. Giant peno-scrotal lymphoedema: surgical considerations and ...

    African Journals Online (AJOL)

    Chronic lymphoedema can affect any parts of the body, including the scrotum and penis. Massive scrotal lymphoedema with gross genital deformation is called penoscrotal elephantiasis1. Penoscrotal elephantiasis can be a functionally and emotionally incapacitating dilemma to the patients. Usually patients suffer from ...

  12. Building a Better Strategic Analyst: A Critical Review of the U.S. Army’s All Source Analyst Training Program

    Science.gov (United States)

    2008-05-15

    intelligence enterprise to describe the idea used in this monograph. 12 David Brooks, “The Elephantiasis of Reason,” The Atlantic Monthly. (January/February... Elephantiasis of Reason”. The Atlantic Monthly. (January/February, 2003). Boyd, Dennis & Bee, Helen. 2006. Lifespan Development. Fourth Edition. Allyn

  13. A Study of Bancroftian Filariasis on the Islands of Batan and Rapu Rapu, Philippines

    Science.gov (United States)

    1988-06-01

    difficult duefrom which cases of elephantiasis were to the mountainous terrain and absence of reported to have originated (pers. comm. Division of Disease...iis in each village exhibited elephantiasis . The local people attributed the cause to walking were infective with third-stage larvae, and in cool

  14. An Annotated Bibliography of the Mosquitoes and Mosquito-Borne Diseases of Guam (Diptera: Culicidae)

    Science.gov (United States)

    1976-01-01

    of elephantiasis , with 83 Americans and 28 natives admitted during the year with dengue fever, No cases of malaria were known to have originated on...group, p. 109. Mosquito Systematics Vol. 8(4) 1976 -3e *South Pacific Conmission. 1951. Conference of experts on filariasis and elephantiasis . So

  15. A Guide to Handling Biomedical Data

    Science.gov (United States)

    1982-01-01

    Scrotal pain? I = yes SCRPN 2 = no 9 = unk 27 Chyluria? 1 = yes CHUIA 2 = no 9 = unk 28 Malaria? I = yes MALIA 2 = no 9 = unk 29 Elephantiasis ? I = yes...33 Thickened epicdidymis I = yes THKEP 2 = no 9 = unk 34 Elephantiasis Scrotum Breat? I = yes SCBRE 2 = no 9 = unk 35 Hackett Spleen (1-5 ps; o-5; 9

  16. Pulmonary Manifestations in Filariasis.

    Science.gov (United States)

    1977-07-15

    enlarged epididimis. Elephantiasis of lower limbs occurred in 1.15% of the cases while lymphatic edema of the lower limbs occurred in 6.84% of the cases. The...prevalence of filaraemia and elephantiasis in the young age group age group indicates active transmission. In a comparison of the thick smear method

  17. The KRA Canal and Thai Security

    Science.gov (United States)

    2002-06-01

    created pockets of minorities; many carry diseases such as elephantiasis and malaria. For example, Ranong Province is presently facing the recurrence...of elephantiasis . This disease, which had long disappeared from Thailand, is now spreading rapidly.42 Furthermore, some of the illegal workers are

  18. Plaadid / Mart Kalvet, Priit Kenkmann, Urmas Piht...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Uutest heliplaatidest Nihilisticrypt "Perverse Dark Somnolence", Nortt "Galgenfrist", Rotten Sound "Cycles", Severe Torture "Sworn Vengeance", Saattue "Jäähyvästi", Steel Scream "Lock n'load and get ready", Cosa Nostra Klub "L'Hymne a la Joie"

  19. Eesti Muinsuskaitse Seltsi rahvusvaheline koostöö / Helle Solnask

    Index Scriptorium Estoniae

    Solnask, Helle

    2009-01-01

    Osalemisest Euroopa Muinsuskaitsepäevade koordinaatorite töögrupis, HEREIN'is, Europa Nostras, Euroopa Ajalooliste Kalmistute Assotsiatsioonis ASCE, Euroopa Muuseumi- ja Turismiraudteede Föderatsioonis

  20. Prospettive della scienza

    CERN Document Server

    Eigen, Manfred

    1991-01-01

    Che vuol dire e a quale scopo dedicarsi alla ricerca di base ; Mozart, ovvero la nostra incapacità di comprendere il genio ; l'"Homunculus" nell'epoca delle biotecnologie ; spirale della crescita e scarsità.

  1. Tracce di sé: il rito del commiato laico tra commemorazione e narrazione

    Directory of Open Access Journals (Sweden)

    Marina Brancato

    2006-09-01

    Full Text Available Far risuonare la situazione luttuosa in un valore di memoria, in un valore morale: valorizzare le sfumature, la ricchezza e la pluralità delle esperienze e di insegnamenti che abbiamo ricevuto in quel meraviglioso e variegato percorso che è la nostra vita. La profonda esigenza di un rito volto a commemorare la persona quale era in vita risponde alla cultura della nostra epoca, attribuendo in tal modo un'importanza nodale all'individualità di ciascuno.

  2. Some interesting Gasteroid ans Secotioid fungi from Sonora, Mexico

    NARCIS (Netherlands)

    Moreno, G.; Esteve-Raventós, F.

    2007-01-01

    Nine rare species of gasteroid and secotioid fungi from Sonora, Mexico are treated here: Agaricus texensis (= Longula texensis), Araneosa columellata, Calvatia bicolor, C. craniiformis, C. pygmaea, Disciseda hyalothrix, D. verrucosa, Endoptychum arizonicum, and D. stuckertii (= Abstoma stuckertii),

  3. Neurofibromatosis: lymphoscintigraphic observations

    International Nuclear Information System (INIS)

    Sty, J.R.; Starshak, R.J.; Woods, G.A.

    1981-01-01

    The authors describe the lymphoscintigraphic findings in a 4-year-old child with neurofibromatosis, the principal manifestation of which was elephantiasis neuromatosa involving the right lower extremity. The lymphoscintigram demonstrated dilated lymphatics and enlarged lymph nodes

  4. Tuberculosis Lymphoedema Cutis

    Directory of Open Access Journals (Sweden)

    Gangopadhyay Asok Kumar

    2001-01-01

    Full Text Available Lymphoedema following cutaneous tuberculosis is a rare occurrence. A case of elephantiasis of leg following lupus vulgaris is presented. It can still be seen in rural India in untreated advanced cutaneous tuberculosis.

  5. Porosity structure of green polybag of medium density fiberboard from seaweed waste

    Science.gov (United States)

    Alamsjah, M. A.; Subekti, S.; Lamid, M.; Pujiastuti, D. Y.; Kurnia, H.; Rifadi, R. R.

    2018-04-01

    The last decade shown that the needs Medium Density Fibreboard (MDF) rapidly growing in Asia Pacific and Europe up to more 15 % per year. MDF made up of fibers lignoselulosa which combined with synthetic resin or tied other suitable but high temperatures and pressure. Technology engineering for green polybag of MDF from seaweed waste of Kappaphycus alvarezii and Gracilaria verrucosa is an alternative effort for ecosystem stability and technological innovations that is environmentally friendly. Structure porosity from the shape of green polybag shows that performance seaweed waste of K. alvarezii is better than seaweed waste of G. verrucosa. The circulation of water happened more optimal in green polybag formed from MDF of seaweed waste of K. alvarezii with size porosity 3.976 µm, while size porosity of seaweed waste of G. verrucosa measurable 4.794 µm. Structure of green polybag of MDF from seaweed waste showed that C components greater 50 % to K. alvarezii while C components less than 50 % to G. verrucosa. This resulted in the ties to structure of MDF stronger found in green polybag derived from seaweed waste of K. alvarezii than G. verrucosa.

  6. La reconfiguración de la familia en la posmodernidad: una perspectiva jurídica, sociológica y política

    OpenAIRE

    Herranz Salazar, Almudena

    2013-01-01

    Aquest treball analitza la influència del individualisme i el dret subjectiu en la reconfiguració de la família postmoderna. La família, tal i com es vol redefinir avui, ja no es limita a un model de família nuclear sinó que ha adoptat diferents models que no s’havien donat fins ara en la nostra cultura. Davant d’aquest fenomen, la nostra intenció és estudiar la transformació que s’ha donat a Espanya de la família i veure les conseqüències que té per la nostra societat.

  7. L'invasione del virtuale

    Directory of Open Access Journals (Sweden)

    Renzo Carlucci

    2005-07-01

    Full Text Available L'ormai indiscutibile il fatto di essere talmente circondati dal virtuale sintetico che quasi si fa fatica a riconoscere la realtà, col suo corollario di fatti “veri” legati alla nostra vita, dalle ricostruzioni digitali che permeano la nostra quotidianità (ogni riferimento al mondo di “Matrix” è puramente casuale; con l’avvento dei moderni sensori è poi veramente impressionante vedere quanto ormai il nostro ambiente sia “contaminato” dal virtuale.

  8. Circulating fibrosis markers, eosinophil cationic protein and eosinophil protein X in patients with Wuchereria bancrofti infection: association with clinical status

    Directory of Open Access Journals (Sweden)

    Esterre P.

    2006-06-01

    Full Text Available We measured the concentrations of several circulating fibrosis markers (type I collagen I, type III procollagen, hyaluronan and eosinophil granule proteins (ECP and EPX in lymphatic filariasis patients to investigate their relationship with clinical, parasitological and immunological data. This study was conducted in Polynesian patients with various stages of the disease (acute lymphangitis, chyluria, hydrocoele, elephantiasis, a closely related microbial lymphangitis and endemic controls. We observed modifications of the different markers in this pathology. Serum type I collagen and PIIINP were decreased. Serum hyaluronan, linked to perilymphatic granulomatous inflammation, was significantly increased in acute lymphangitis and elephantiasis patients. Serum ECP was also increased, at the limit of significance in our sample, in elephantiasis patients. These two last markers, already validated in another helminth disease, schistosomiasis, have potential interest in terms of follow-up of morbidity in these parasitic diseases.

  9. Some Physical, Chemical, and Biological Parameters of Samples of Scleractinium Coral Aquaculture Skeleton Used for Reconstruction/Engineering of the Bone Tissue.

    Science.gov (United States)

    Popov, A A; Sergeeva, N S; Britaev, T A; Komlev, V S; Sviridova, I K; Kirsanova, V A; Akhmedova, S A; Dgebuadze, P Yu; Teterina, A Yu; Kuvshinova, E A; Schanskii, Ya D

    2015-08-01

    Physical and chemical (phase and chemical composition, dynamics of resorption, and strength properties), and biological (cytological compatibility and scaffold properties of the surface) properties of samples of scleractinium coral skeletons from aquacultures of three types and corresponding samples of natural coral skeletons (Pocillopora verrucosa, Acropora formosa, and Acropora nobilis) were studied. Samples of scleractinium coral aquaculture skeleton of A. nobilis, A. formosa, and P. verrucosa met the requirements (all study parameters) to materials for osteoplasty and 3D-scaffolds for engineering of bone tissue.

  10. Bioaccumulation studies in a benthic marine species in different radioactivity concentrations

    International Nuclear Information System (INIS)

    Stamouli, M.; Papadopoulou, C.

    1992-07-01

    The accumulation of trivalent and hexavalent 51Cr by the mollusc Venus verrucosa in three different radioactivity concentrations was studied. The bioavailability of the trivalent 51Cr was found to be much higher than that of the hexavalent 51Cr. Also the uptake patterns of 51Cr(III) and 51Cr(VI) were different. This distribution of the accumulated trivalent and hexavalent 51Cr in the body of Venus verrucosa was investigated and appeared to be influenced by the valence state of 51Cr. The elimination of the accumulated radioactivity was also investigated and the effective and biological half lives for the two year valence states of 51Cr were determined

  11. calvyn oor die leiding van die heilige gees in die verklaring van die

    African Journals Online (AJOL)

    Mittel alters, bis er zur Ruhe kommt bei den kanonischen Schriften der. Urzeit der christlichen Ära (Barth ... (ego tamen dimoveri non possum ab amore compendii, CO 10, 403). Deur die boodskap van die .... Idem ergo spiritus qui per os prophetarum loquutus est, in corda nostra penetret necesse est, ut persuadeat fideliter ...

  12. Dwelling towers of Czech castles

    Czech Academy of Sciences Publication Activity Database

    Durdík, Tomáš

    2009-01-01

    Roč. 63, - (2009), s. 139-150 ISSN 1875-2896. [Meeting of Europa Nostra Scientific Council /44./. Kilkenny, 27.09.2008-02.10.2008] Institutional research plan: CEZ:AV0Z80020508 Keywords : castle * castellology * dwelling tower * donjon * keep * medieval archaeology * architecture * Bohemia * Middle Ages Subject RIV: AC - Archeology, Anthropology, Ethnology

  13. Shaping of the axial power density distribution in the core to minimize the vapor volume fraction at the outlet of the VVER-1200 fuel assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Savander, V. I.; Shumskiy, B. E., E-mail: borisshumskij@yandex.ru [National Research Nuclear University MEPhI (Russian Federation); Pinegin, A. A. [National Research Center Kurchatov Institute (Russian Federation)

    2016-12-15

    The possibility of decreasing the vapor fraction at the VVER-1200 fuel assembly outlet by shaping the axial power density field is considered. The power density field was shaped by axial redistribution of the concentration of the burnable gadolinium poison in the Gd-containing fuel rods. The mathematical modeling of the VVER-1200 core was performed using the NOSTRA computer code.

  14. Spendere meno, spendere meglio: una proposta panottica di J.-C. Guédon

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2013-06-01

    Full Text Available J.-C. Guédon ha commentato la nostra campagna di crowdsourcing in merito alle spese delle biblioteche sulla mailing list Nexa. Offriamo, qui di seguito, la versione italiana delle sue osservazioni – che presuppongono un mondo accademico molto diverso da quello impostoci...

  15. LIFE-WRITING / NARRARSI

    African Journals Online (AJOL)

    User

    12 nov 2004 ... pochi minuti, prima che il vecchio scendesse dall'autobus, una sorta di intimità fra di noi che ricordo mi infastidiva. Una vicinanza eccessiva che mi faceva percepire chiaramente quanto incolmabile fosse la nostra distanza. Prima di scendere dall'autobus quel vecchio mi diede altri consigli su argomenti ...

  16. Giustizia, uguaglianza e differenza

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2013-02-01

    Full Text Available E’ una guida alla lettura della filosofia politica contemporanea, a cura di Brunella Casalini e Lorenzo Cini, pubblicata da Firenze University Press per la nostra collana ad accesso aperto Methexis. La versione digitalizzata del testo è a disposizione di tutti.

  17. Control mental

    OpenAIRE

    Bueno i Torrens, David, 1965-

    2013-01-01

    La revista especialitzada NeuroReport ha publicat un article que m'ha aportat nous elements de reflexió sobre els mecanismes neurals de control mental que, de forma innata, realitzem les persones com a part de la nostra vida social.

  18. Momenti nella vita di uno scienziato

    CERN Document Server

    Rossi, Bruno

    1987-01-01

    Nel giro di pochi decenni, la nostra visione del mondo fisico, dal mond subatomico al mondo del cosmo, ha subito una profonda evoluzione. In questo libro, uno degli scienziati che hanno contribuito a tale sviluppo narra la storia della sua vita e del suo lavoro.

  19. Democrazia e scrittura della storia

    NARCIS (Netherlands)

    de Baets, Antoon

    2015-01-01

    In questo saggio cerchiamo di chiarire le relazioni fra la democrazia e la scrittura della storia. La nostra strategia consiste nell’esplorare innanzitutto la relazione generale fra la democrazia e la coscienza storica per poi esaminare quella fra la democrazia e la storiografia in quanto tale,

  20. Pop / Tõnu Kaalep

    Index Scriptorium Estoniae

    Kaalep, Tõnu, 1966-2018

    2003-01-01

    Heliplaatidest: Steve Reich "Three Tales", Finley Quaye "Much More Than Much Love", Boo Yaa Tribe "West Koasta Nostra", Robert Plant "Sixty Six To Timbuktu", Ryan Adams "Rock N Roll", Triosk meets Jan Jelinek "1+3+1", Mice Parade "Obrigado Saudade"

  1. Lorenzo Cini, Società civile e democrazia radicale

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2013-02-01

    Full Text Available La nostra collana Methexis ha pubblicato ad accesso aperto il volume di Lorenzo Cini, Società civile e democrazia radicale, Firenze, Firenze University Press, 2012. La versione digitale del testo, in formato PDF, è a disposizione di tutti presso l’archivio elettronico dell'editore.

  2. Andare a consumare

    Directory of Open Access Journals (Sweden)

    Andreas Fernandez

    2009-03-01

    Non si sorprende più nessuno quando si afferma che il rilievo crescente rivestito dalla cultura e dalle pratiche di consumo nella nostra vita di tutti i giorni, nelle relazioni interpersonali che ci coinvolgono e, ovviamente, nell’universo economico, ha reso la produzione sempre meno nucleo di interesse delle scienze sociali.

  3. Metabolic rates and tissue composition of the coral Pocillopora verrucosa over 12 latitudes in the Red Sea characterized by strong temperature and nutrient gradient, supplement to: Sawall, Yvonne; Al-Sofyani, A; Hohn, S; Banguera-Hinestroza, E; Voolstra, Christian R; Wahl, Martin (2015): Extensive phenotypic plasticity of a Red Sea coral over a strong latitudinal temperature gradient suggests limited acclimatization potential to warming. Scientific Reports, 5, 8940

    KAUST Repository

    Sawall, Yvonne; Al-Sofyani, A; Hohn, S; Banguera-Hinestroza, E; Voolstra, Christian R.; Wahl, Martin

    2015-01-01

    Global warming was reported to cause growth reductions in tropical shallow water corals in both, cooler and warmer, regions of the coral species range. This suggests regional adaptation with less heat-tolerant populations in cooler and more thermo

  4. Analysis of liquid extracts from tree and grass pollens by capillary electromigration methods

    Czech Academy of Sciences Publication Activity Database

    Sázelová, Petra; Kašička, Václav; Koval, Dušan; Peltre, G.

    2004-01-01

    Roč. 808, č. 1 (2004), s. 117-123 ISSN 0378-4347 R&D Projects: GA MŠk OK 382 Grant - others:INCO-Copernicus(XE) ERB IC15 CT98 0322 Institutional research plan: CEZ:AV0Z4055905 Keywords : Betula verrucosa * Dactylis glomerata * pollen allergens Subject RIV: CE - Biochemistry Impact factor: 2.176, year: 2004

  5. A prospective study comparing the efficacy and safety of two sublingual birch allergen preparations

    NARCIS (Netherlands)

    Klimek, Ludger; Sperl, Annette; van Twuijver, Esther; van Ree, Ronald; Kleinjans, Huub; Boot, Johan Diderik; Pfaar, Oliver

    2014-01-01

    Background: SUBLIVAC FIX Birch (SUB-B) is a liquid oral preparation of Betula verrucosa pollen extract for the treatment of allergic rhinitis/rhinoconjuctivitis induced by birch pollen. The major allergen content of SUB-B and Staloral Birch (Stal-B) have been shown to be comparable. In order to

  6. Verrucous hemangioma

    Directory of Open Access Journals (Sweden)

    M J Cyriac

    1990-01-01

    Full Text Available A 45 years old male had a warty growth on the thigh diagnosed as verrucous hemangioma histopathologically. Earlier he had received treatment under the clinical diagnoses of verruca vulgaris and tuberculosis verrucosa cutis. The lesion was treated with surgical excision and grafting.

  7. Possible antimicrobial activity of Morinda lucida stem bark, leaf and ...

    African Journals Online (AJOL)

    MR FAKOYA AKINDELE

    2014-01-15

    Jan 15, 2014 ... are used in the treatment of different types of diseases. Roots, barks or leaves of Newbolbea leavis are used in the treatment of dysentery, syphilis, ear ache, ringworm and scrotal elephantiasis (Azoro, 2002.) Morinda lucida known as Oruwo in the South-Western part of Nigeria is a medium sized tree with a ...

  8. A 24-year-old Ethiopian Farmer with Burning Feet

    NARCIS (Netherlands)

    Visser, Benjamin Jelle; Korevaar, Daniel Arnoldus; van der Zee, Janneke

    2012-01-01

    Podoconiosis is a non-infectious tropical disease caused by exposure of bare feet to irritant alkalic clay soils. This causes an asymmetrical swelling of the feet and lower limbs due to lymphoedema. This swelling is called "elephantiasis" and may lead to severe disability of the patient. It is found

  9. Podoconiosis, a neglected tropical disease

    NARCIS (Netherlands)

    Korevaar, D. A.; Visser, B. J.

    2012-01-01

    Podoconiosis or 'endemic non-filarial elephantiasis' is a tropical disease caused by exposure of bare feet to irritant alkaline clay soils. This causes an asymmetrical swelling of the feet and lower limbs due to lymphoedema. Podoconiosis has a curable pre-elephantiasic phase. However, once

  10. Lymphatic filariasis in Luangwa District, South-East Zambia

    DEFF Research Database (Denmark)

    Shawa, Sheila Tamara; Mwase, Enala T.; Pedersen, Erling Møller

    2013-01-01

    and intensity of Bm14 antibodies were much higher in individuals ≥ 30 years than in younger individuals (57.2 vs. 19.3%; 0.594 vs. 0.241 OD-values). Elephantiasis and hydrocele were well known clinical manifestations in the area, but only one case of hydrocele was detected in the study population. Identified...

  11. Elevated levels of T cell activation antigen CD27 and increased interleukin-4 production in human lymphatic filariasis

    NARCIS (Netherlands)

    Yazdanbakhsh, M.; Sartono, E.; Kruize, Y. C.; Kurniawan, A.; van der Pouw-Kraan, T.; van der Meide, P. H.; Selkirk, M. E.; Partono, F.; Hintzen, R. Q.; van Lier, R. A.

    1993-01-01

    To assess the immunological changes occurring during filarial infection with or without elephantiasis, 145 patients in different clinical groups from an endemic area in Indonesia were compared with respect to plasma levels of both soluble CD25 (sCD25) and sCD27; interleukin-4 (IL-4) and

  12. Surgical manifestations of filariasis

    Directory of Open Access Journals (Sweden)

    Subrahmanyam M

    1978-01-01

    Full Text Available Surgical manifestations of filariasis as seen in 150 cases over a period of three years in the department of Surgery, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha are reviewed. The genital manifestations are more common than the elephantiasis in this endemic zone.

  13. Genital manifestations and reproductive health in female residents of a Wuchereria bancrofti-endemic area in Tanzania

    DEFF Research Database (Denmark)

    Bernhard, P; Makunde, R W; Magnussen, P

    2000-01-01

    primarily on reproductive history and genital health. In a population of 2165 residents, prevalence of Wuchereria bancrofti microfilaraemia was 28%, and geometric mean intensity of microfilariae (mf) was 722 mf/mL. Leg lymphoedema (elephantiasis) was present in 4.2% of adults aged > or = 15 years...

  14. Lymphatic filariasis in Lower Shire, southern Malawi

    DEFF Research Database (Denmark)

    Nielsen, N. O.; Makaula, P.; Nyakuipa, D.

    2002-01-01

    positive for microfilariae, and 62.3% and 64.6% were positive for CFA in the 2 villages. Among those aged ≥15 years, 3.7% and 1.3% had leg elephantiasis, and 17.9% and 13.0% (of males only) had hydrocoele. In both phase II and III, CFA prevalences were unexpectedly high, especially in children...

  15. Typical computer tomographic findings in neurofibromatosis

    International Nuclear Information System (INIS)

    Allgayer, B.; Reiser, M.; Kramann, B.

    1984-01-01

    Three pateints with neurofibromatosis (Recklinghausen's disease) were examined by computer tomography. In this way, the exact extent and localisation of the neurofibromatous tumours could be demonstrated. In one patient, CT provided evidence of malignant change; this was verified histologically. The appearances of neurofibromatosis associated with elephantiasis is described. In each patient, treatment was significantly influenced by computer tomography. (orig.) [de

  16. Typical computer tomographic findings in neurofibromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Allgayer, B.; Reiser, M.; Kramann, B.

    1984-06-01

    Three pateints with neurofibromatosis (Recklinghausen's disease) were examined by computer tomography. In this way, the exact extent and localisation of the neurofibromatous tumours could be demonstrated. In one patient, CT provided evidence of malignant change; this was verified histologically. The appearances of neurofibromatosis associated with elephantiasis is described. In each patient, treatment was significantly influenced by computer tomography.

  17. Lymphatic Filariasis: Transmission, Treatment and Elimination

    NARCIS (Netherlands)

    W.A. Stolk (Wilma)

    2005-01-01

    textabstractLymphatic filariasis (LF) is a mosquito-borne, tropical disease caused by filarial worms. Infection can lead to disabling chronic disease, characterized by swelling of extremities or external genitalia (lymphoedema, elephantiasis and hydrocele). Mass treatment with antifilarial drugs is

  18. How soil scientists help combat podoconiosis, a neglected tropical disease

    NARCIS (Netherlands)

    Visser, Benjamin Jelle

    2014-01-01

    Podoconiosis or "endemic non-filarial elephantiasis" is a tropical disease caused by prolonged exposure of bare feet to irritant alkaline clay soils of volcanic origin [1]. The name of the disease is derived from the Greek words for foot: podos, and dust: konos. Small mineral particles from irritant

  19. Hydrocoele: A Silent Disability Affecting Quality of Life in Katakwi ...

    African Journals Online (AJOL)

    Background: Katakwi district is one of the rural districts in eastern Uganda in Teso Sub Region. The district is heavily infested with filarial worms a major cause for hydrocoele and elephantiasis if the infection is left untreated. Hydrocoele in Katakwi district are still a big cause of silent morbidity though it's an operable ...

  20. Il processo Andreotti. Il confine labile fra la partecipazione e il concorso esterno nei reati associativi

    Directory of Open Access Journals (Sweden)

    Paolo Intoccia

    2017-11-01

    Full Text Available Prendendo in esame un procedimento penale d’eccezione nel presente elaborato ci si propone di condurre uno studio sul diritto penale ‘in azione’ allo scopo di verificare i meccanismi di applicazione dei reati di associazione per delinquere ‘semplice’ (a. 416 c.p. e di tipo mafioso (a. 416 bis c.p.. La seguente analisi ricostruisce, infatti, l’intensa trafila giudiziaria che ha visto protagonista Giulio Andreotti – dal 4 marzo 1993 chiamato a rispondere, prima a titolo di concorrente esterno e successivamente in qualità di partecipe, dei due reati associativi sopra richiamati a fronte di un apparato accusatorio qualitativamente complesso e temporalmente imponente. Sarà in tal modo possibile verificare quanto possa essere labile, specie ove si discuta della condotta di fiancheggiamento di un soggetto politico ad un sodalizio di tipo mafioso (qui Cosa Nostra, il confine tra la fenomenologia partecipativa (nel ruolo di intraneus all’associazione e quella concorsuale eventuale (nel ruolo di cd. concorrente esterno nei delitti associativi di cui agli artt. 416 e 416 bis c.p. Parole chiave: Andreotti, Cosa Nostra, zona grigia, reati associativi, mala informazione   By examining an exceptional criminal proceeding in this paper we propose to conduct a study on criminal law ‘in action’ in order to verify the mechanisms of application of two associative offenses (‘simple’ criminal conspiracy and mafia-type criminal conspiracy. As a matter of fact the analysis reconstructs the intense trial about Giulio Andreotti’s working with Cosa Nostra – Andreotti, starting from March 4 1993, is accused of being at first an external competitor and subsequently a participant of Cosa Nostra in connection with a qualitatively complex accusatory apparatus. As a result of this analysis we come to ascertain how fleeting the boundary between the role of partecipant and external competitor in a criminal conspiracy can be, especially in case of

  1. Transformació de dades pel comerç electrònic de Tous

    OpenAIRE

    Fernández Artidiello, Carlos Rafael

    2013-01-01

    Aquest projecte es tracta de la creació d'una aplicació que ens ajudarà a establir comunicació entre la web de comerç on-line de l'empresa “Joieria Tous”, que estarà administrat per “GSI Commerce” i el sistema informàtic de la nostra central logística. Observarem que el sistema actual és totalment propietari i fet a mida, llavors per poder tenir una comunicació amb les noves botigues on-line s'ha de crear una plataforma que transformi les dades d'entrada al sistema informàtic de la nostra emp...

  2. Cimiteri nella natura, come natura, come città

    Directory of Open Access Journals (Sweden)

    Luigi Franciosini

    2012-06-01

    Full Text Available I luoghi di sepoltura sono destinati a diffondere e proteggere il sentimento di lutto legato alla perdita e ad indicarne, attraverso una rappresentazione simbolica, una via possibile di consolazione e di un sereno ricordo, essi sono testimoni delle diverse identità culturali e religiose: la memoria custodisce e rassicura.Il tema continua a segnare la nostra esistenza: le immagini delle città ci raccontano ancora di  luoghi destinati al ricordo; essi testimoniano anche l’incapacità della nostra cultura di ri-comporre un dialogo consapevole con la morte.Le trasformazioni sociali in atto ci impongono una riflessione sui luoghi di sepoltura: c'è urgenza di nuove spazialità destinate a rappresentare il luogo della comprensione e del dialogo religioso e civile tra le diverse forme di spiritualità.

  3. Trust

    OpenAIRE

    Carro, Salvatore

    2006-01-01

    Il lavoro eseguito ha per oggetto il trust, istituto, come noto, estraneo alla nostra cultura giuridica, tipico dei sistemi di common law, riconosciuto e regolato dalla Convenzione dell’ Aja, firmata il 1°luglio 1985, ratificata in Italia con L. 16 ottobre 1989, n. 364, ed entrata in vigore il 1° giugno 1992. La ricerca svolta ha, in primo luogo, esaminato la fattispecie, con un approccio comparatistico, analizzando, nella prima parte, il contenuto e la controversa natura giuridica della c...

  4. Una rappresentazione simbolica di comunicazione urbana: il graffito

    Directory of Open Access Journals (Sweden)

    Luciano Spinelli

    2008-07-01

    Full Text Available La nostra intenzione è quella di dare una lettura semiotica dello spazio urbano attraverso lo studio dei graffiti necessari, in un’analogia della soggettivazione che il cittadino fa dello spazio nel suo vissuto quotidiano. I suoi graffiti sono integrati ad altri segni proposti dallo Stato e dall’iniziativa privata che compongono così l'apparenza loquace della città polifonica.

  5. Editoriale / Editorial

    Directory of Open Access Journals (Sweden)

    Balloni Augusto

    2011-12-01

    Full Text Available Nel 1991 si è costituita la nostra Società Italiana di Vittimologia (S.I.V. e in questi vent’anni molte attività hanno attirato interesse da parte di diversi settori: si sono sviluppati rapporti con istituzioni del territorio e con organizzazioni nazionali e internazionali; inoltre la Rivista di Criminologia, Vittimologia e Sicurezza è diventata un importante strumento per il giusto riconoscimento e la necessaria visibilità delle vittime.

  6. Il nucleo terrestre: il cuore magnetico della Terra

    OpenAIRE

    De Santis, A.

    2006-01-01

    Il campo magnetico terrestre è una proprietà intrinseca del nostro pianeta e di altri oggetti del sistema solare. Il Sole stesso possiede un forte campo magnetico che si inverte quasi ciclicamente ogni 10-11 anni; tale comportamento è visibile attraverso la medesima ciclicità delle macchie solari che denotano sulla superficie l’intensa attività magnetica della nostra stella. Il campo magnetico terrestre è importantissimo per la vita sulla Terra. Esso protegge il pianeta dalle p...

  7. Som Energia: sostenibilitat energètica i cooperativisme

    OpenAIRE

    Duran i Grant, Alexandre; Huijink, Gijsbert; Roselló, Marc

    2013-01-01

    La cooperativa Som Energia és una organització innovadora en el sector energètic a casa nostra. Proposa una forma de fer diferent de la de les empreses tradicionals del sector: ven energia renovable certificada, no té ànim de lucre i busca el bé comú. La proposta treballa per la sostenibilitat energètica.

  8. Oggetti e memoria domestica

    Directory of Open Access Journals (Sweden)

    Marina Brancato

    2011-12-01

    Full Text Available Questo contributo è un ideale viaggio nella memoria attraverso le stanze che compongono le nostre case. Un itinerario fra gli oggetti che fanno da sfondo quotidiano alla nostra scenografia domestica. Nello specifico indagheremo album fotografici, souvenir, ninnoli (mnemoteche domestiche. Sin dall’inizio abbiamo considerato gli ambienti domestici veri e propri serbatoi di memorie individuali e collettive. In tali serbatoi i soggetti depositano tracce delle proprie biografie, esprimendo e confermando progetti identitari.

  9. Interreligious Dialogue: A Roman Catholic Perspective

    OpenAIRE

    Gregory Baum

    2011-01-01

    To promote peace, justice and freedom in a deeply divided world, the Catholic Church at Vatican Council II promulgated the declaration Nostra aetate in 1965,expressing its respect for the world religions and recommending dialogue and cooperation with their followers. This was a startling event, since from its very beginning the Catholic Church, and in fact all the Christian Churches, wanted to convert the entire world to the Christian faith. Nostae aetate also transformed the relationship of ...

  10. Les Matemàtiques són el cor del món

    OpenAIRE

    Canals, Maria Antònia

    2009-01-01

    És evident que per als que ens dediquem a l’ensenyament de les matemàtiques, l’amor a la nostra feina ens empeny sempre a reunir-nos. Aquest any la gent de Girona ha tingut una bona ocasió de constatar-ho, i ha pogut preguntar-se per què es produeix aquest fet

  11. La mente nuova dell'imperatore

    CERN Document Server

    Penrose, Roger

    1992-01-01

    Mente umana e intelligenza artificiale: si tratta di due realtà comparabili? A quali leggi della fisica (classica o quantistica) obbedisce la nostra mente? Un giorno i computer potranno ragionare esattamente come noi? In questo libro di divulgazione scientifica, che al suo apparire ha provocato vivaci polemiche, l'autore afferma che la "mente nuova", che l'intelligenza artificiale sostiene di poterci dare, è qualcosa di profondamente diverso dalla mente dell'uomo.

  12. When shape matters: strategies of different Antarctic ascidians morphotypes to deal with sedimentation

    OpenAIRE

    Torre, Luciana; Abele, Doris; Lagger, Cristian; Momo, Fernando; Sahade, Ricardo

    2014-01-01

    Climate change leads to increased melting of tidewater glaciers in theWestern Antarctic Peninsula region and sediment bearing glacial melt waters negatively affects filter feeding species as solitary ascidians. In previous work the erect-forms Molgula pedunculata and Cnemidocarpa verrucosa (Order Stolidobranchiata) appeared more sensitive than the flat form Ascidia challengeri (Order Phlebobranchiata). Sedimentation exposure is expected to induce up-regulation of anaerobic metabol...

  13. Histopathological Features Of Granulomatous Skin Diseases : An Analysis Of 22 Skin Biopsies

    Directory of Open Access Journals (Sweden)

    Dhar Subhra

    2002-01-01

    Full Text Available In the present study, skin biopsies were analysed for histopathological (HP changes in 22 patients with various granulomatous dermatoses. In 6 specimens, HP features were diagnostic of BT leprosy, in 1 each of BB, BL and historid LL. The HP features were was lupus valugaris (LV in 6 biopsies, tuberculosis verrucosa cutis (TBVC in 2, sarcoidosis in 3 and sporotrichosis in remaining 2. The study reiterated the usefulness of HP examination of all suspected cases of granulomatous skin diseases.

  14. Microbial Diversity of Betula Trees: Pollen, Catkins, Leaves Relatively of Flowering

    OpenAIRE

    Tetiana V. Shevtsova; Jana Petrová; Ján Brindza; Kateryna G. Garkava; Miroslava Kačániová

    2016-01-01

    Quantitative microbiological analysis by dilution plating method of pollen and additional male and female catkins, leaves of Betula verrucosa Ehrh. and its two cultivars: ‘Purpurea’ and ‘Youngii’ relatively of flowering period of Betula has been realized with the aim to provide new knowledge of the microbiological quality of anemophilous pollen for processing and its further application. Qualitative microbiological analysis with MALDI-TOF MS Biotyper was used in the identification of aerobic,...

  15. Histopathological Features Of Granulomatous Skin Diseases : An Analysis Of 22 Skin Biopsies

    OpenAIRE

    Dhar Subhra; Dhar Sandipan

    2002-01-01

    In the present study, skin biopsies were analysed for histopathological (HP) changes in 22 patients with various granulomatous dermatoses. In 6 specimens, HP features were diagnostic of BT leprosy, in 1 each of BB, BL and historid LL. The HP features were was lupus valugaris (LV) in 6 biopsies, tuberculosis verrucosa cutis (TBVC) in 2, sarcoidosis in 3 and sporotrichosis in remaining 2. The study reiterated the usefulness of HP examination of all suspected cases of granulomatous skin diseases.

  16. TINJAUAN PSIKOLOGI KESEHATAN PADA PENDERITA PENYAKIT KAKI GAJAH KRONIS DI KABUPATEN BANDUNG

    Directory of Open Access Journals (Sweden)

    Ambar Sulianti

    2016-02-01

    Full Text Available Elephantiasis or Filariasis has been reported endemic in Kabupaten Bandung with potentially result in defects. This research aimed to explore health psychology of chronic Elephantiasis patients in Kabupaten Bandung. Qualitative-descriptive method has been used to explore the respondent’s psychodynamics, health behavior, and treatment seeking behavior, while quantitative-descriptive method has been used to determine the percentage distribution. The result showed that there were three kind of respondent’s psychodynamic namely denial (7.7%, anxiety (85%, and depression (7.7%. Due to the lack of knowledge about the disease, the majority of respondents (77% were hiding their disease.Type of treatment seeking behaviors has been chosen by respondent namely relying to the paranormal (92%, doctors (23%, traditional physician (54%, and acupuncturist (15%.

  17. 'Tales of Symphonia': extinction dynamics in response to past climate change in Madagascan rainforests.

    Science.gov (United States)

    Virah-Sawmy, Malika; Bonsall, Michael B; Willis, Katherine J

    2009-12-23

    Madagascar's rainforests are among the most biodiverse in the world. Understanding the population dynamics of important species within these forests in response to past climatic variability provides valuable insight into current and future species composition. Here, we use a population-level approach to analyse palaeoecological records over the last 5300 years to understand how populations of Symphonia cf. verrucosa became locally extinct in some rainforest fragments along the southeast coast of Madagascar in response to rapid climate change, yet persisted in others. Our results indicate that regional (climate) variability contributed to synchronous decline of S. cf. verrucosa populations in these forests. Superimposed on regional fluctuations were local processes that could have contributed or mitigated extinction. Specifically, in the forest with low soil nutrients, population model predictions indicated that there was coexistence between S. cf. verrucosa and Erica spp., but in the nutrient-rich forest, interspecific effects between Symphonia and Erica spp. may have pushed Symphonia to extinction at the peak of climatic change. We also demonstrate that Symphonia is a good indicator of a threshold event, exhibiting erratic fluctuations prior to and long after the critical climatic point has passed.

  18. Differential specificity between closely related corals and abundant Endozoicomonas endosymbionts across global scales

    KAUST Repository

    Neave, Matthew J.

    2016-07-08

    Reef-building corals are well regarded not only for their obligate association with endosymbiotic algae, but also with prokaryotic symbionts, the specificity of which remains elusive. To identify the central microbial symbionts of corals, their specificity across species and conservation over geographic regions, we sequenced partial SSU ribosomal RNA genes of Bacteria and Archaea from the common corals Stylophora pistillata and Pocillopora verrucosa across 28 reefs within seven major geographical regions. We demonstrate that both corals harbor Endozoicomonas bacteria as their prevalent symbiont. Importantly, catalyzed reporter deposition–fluorescence in situ hybridization (CARD–FISH) with Endozoicomonas-specific probes confirmed their residence as large aggregations deep within coral tissues. Using fine-scale genotyping techniques and single-cell genomics, we demonstrate that P. verrucosa harbors the same Endozoicomonas, whereas S. pistillata associates with geographically distinct genotypes. This specificity may be shaped by the different reproductive strategies of the hosts, potentially uncovering a pattern of symbiont selection that is linked to life history. Spawning corals such as P. verrucosa acquire prokaryotes from the environment. In contrast, brooding corals such as S. pistillata release symbiont-packed planula larvae, which may explain a strong regional signature in their microbiome. Our work contributes to the factors underlying microbiome specificity and adds detail to coral holobiont functioning.

  19. Evaluation of ethanol production and bioadsorption of heavy metals by various red seaweeds.

    Science.gov (United States)

    Sunwoo, In Yung; Ra, Chae Hun; Jeong, Gwi-Taek; Kim, Sung-Koo

    2016-06-01

    The objective of this study was to evaluate ethanol production and bioadsorption with four red seaweeds, Gelidium amansii, Gracilaria verrucosa, Kappaphycus alvarezii and Eucheuma denticulatum. To produce ethanol, thermal acid hydrolysis, enzymatic saccharification and fermentation was carried out. After pretreatment, 38.5, 39.9, 31.0 and 27.5 g/L of monosaccharides were obtained from G. amansii, G. verrucosa, K. alvarezii and E. denticulatum, respectively. Ethanol fermentation was performed with Saccharomyces cerevisiae KCCM 1129 adapted to 80 g/L galactose. The ethanol productions by G. amansii, G. verrucosa, K. alvarezii and E. denticulatum were 18.8 g/L with Y EtOH = 0.49, 19.1 g/L with Y EtOH = 0.48, 14.5 g/L with Y EtOH = 0.47 and 13.0 g/L with Y EtOH = 0.47, respectively. The waste seaweed slurries after the ethanol fermentation were reused to adsorb Cd(II), Pb(II) and Cu(II). Using langmuir isotherm model, Cu(II) had the highest affinity for waste seaweeds with the highest q max and electronegativity values among three heavy metals.

  20. Differential specificity between closely related corals and abundant Endozoicomonas endosymbionts across global scales

    KAUST Repository

    Neave, Matthew J.; Rachmawati, Rita; Xun, Liping; Michell, Craig; Bourne, David G; Apprill, Amy; Voolstra, Christian R.

    2016-01-01

    Reef-building corals are well regarded not only for their obligate association with endosymbiotic algae, but also with prokaryotic symbionts, the specificity of which remains elusive. To identify the central microbial symbionts of corals, their specificity across species and conservation over geographic regions, we sequenced partial SSU ribosomal RNA genes of Bacteria and Archaea from the common corals Stylophora pistillata and Pocillopora verrucosa across 28 reefs within seven major geographical regions. We demonstrate that both corals harbor Endozoicomonas bacteria as their prevalent symbiont. Importantly, catalyzed reporter deposition–fluorescence in situ hybridization (CARD–FISH) with Endozoicomonas-specific probes confirmed their residence as large aggregations deep within coral tissues. Using fine-scale genotyping techniques and single-cell genomics, we demonstrate that P. verrucosa harbors the same Endozoicomonas, whereas S. pistillata associates with geographically distinct genotypes. This specificity may be shaped by the different reproductive strategies of the hosts, potentially uncovering a pattern of symbiont selection that is linked to life history. Spawning corals such as P. verrucosa acquire prokaryotes from the environment. In contrast, brooding corals such as S. pistillata release symbiont-packed planula larvae, which may explain a strong regional signature in their microbiome. Our work contributes to the factors underlying microbiome specificity and adds detail to coral holobiont functioning.

  1. Risk Factors for Podoconiosis: Kamwenge District, Western Uganda, September 2015.

    Science.gov (United States)

    Kihembo, Christine; Masiira, Ben; Lali, William Z; Matwale, Gabriel K; Matovu, Joseph K B; Kaharuza, Frank; Ario, Alex R; Nabukenya, Immaculate; Makumbi, Issa; Musenero, Monica; Zhu, Bao-Ping; Nanyunja, Miriam

    2017-06-01

    AbstractPodoconiosis, a noninfectious elephantiasis, is a disabling neglected tropical disease. In August 2015, an elephantiasis case-cluster was reported in Kamwenge District, western Uganda. We investigated to identify the disease's nature and risk factors. We defined a suspected podoconiosis case as onset in a Kamwenge resident of bilateral asymmetrical lower limb swelling lasting ≥ 1 month, plus ≥ 1 of the following associated symptoms: skin itching, burning sensation, plantar edema, lymph ooze, prominent skin markings, rigid toes, or mossy papillomata. A probable case was a suspected case with negative microfilaria antigen immunochromatographic card test (ruling out filarial elephantiasis). We conducted active case-finding. In a case-control investigation, we tested the hypothesis that the disease was caused by prolonged foot skin exposure to irritant soils, using 40 probable case-persons and 80 asymptomatic village control-persons, individually matched by age and sex. We collected soil samples to characterize irritants. We identified 52 suspected (including 40 probable) cases with onset from 1980 to 2015. Prevalence rates increased with age; annual incidence (by reported onset of disease) was stable over time at 2.9/100,000. We found that 93% (37/40) of cases and 68% (54/80) of controls never wore shoes at work (Mantel-Haenszel odds ratio [OR MH ] = 7.7; 95% [confidence interval] CI = 2.0-30); 80% (32/40) of cases and 49% (39/80) of controls never wore shoes at home (OR MH = 5.2; 95% CI = 1.8-15); and 70% (27/39) of cases and 44% (35/79) of controls washed feet at day end (versus immediately after work) (OR = 11; 95% CI = 2.1-56). Soil samples were characterized as rich black-red volcanic clays. In conclusion, this reported elephantiasis is podoconiosis associated with prolonged foot exposure to volcanic soil. We recommended foot hygiene and universal use of protective shoes.

  2. Diagnostic value of vascular endothelial growth factor and interleukin-17 in association with molecular diagnosis of Wuchereria bancrofti infection

    Directory of Open Access Journals (Sweden)

    Dalia Abdelhamid Omran

    2015-08-01

    Full Text Available Objective: To explore effective diagnosis of Wuchereria bancrofti through DNA-based techniques followed by assessment of vascular endothelial growth factor concentration (VEGF-C and interleukin 17 (IL-17 as indicators for lymphatic endothelial cell activation, proliferation and massive tissue reaction that may be a good indicator for ongoing lymphatic filariasis. Methods: Blood samples were collected from 38 patients: 23 males (60.5% and 15 females (39.5% with filariasis and from controls (60 from a non-endemic and 22 from endemic areas. PCR was used to prove infection. A specific and sensitive ELISA was used to determine serum IL-17 and VEGF-C. Results: A total of 28 patients (46.7% were positive by PCR, while 10 patients (16.7% were negative by PCR. Serum level of vascular endothelial growth factor was significantly high in acute cases [(2 147.00 ± 556.00 pg/mL] and in cases of early elephantiasis [(1 950.00 ± 638.00 pg/mL] and lowest in cases of late elephantiasis, endemic and non endemic controls [(1 238.00 ± 443.00, (807.11 ± 6.20 and (857.00 ± 91.50 pg/mL respectively]. Serum IL-17 was found to be significantly high in acute cases, early elephantiasis and late elephantiasis cases [(8 601 ± 1131, (7 867 ± 473 and (6593 ± 378 pg/mL respectively] when compared to endemic controls [(3 194 ± 1 500 pg/mL] and non endemic controls [(3 416 ± 1 101 pg/mL]. Conclusions: VEGF-C and its inducing factor IL-17 are expected to gain more importance in filariasis. Targeting such factors might ameliorate the pathology in chronic filariasis.

  3. INFEKSI WUCHERERIA BANCROFTI DI SAUKOREM DAN WEFIANI KABUPATEN MANOKWARI, IRIAN JAYA

    Directory of Open Access Journals (Sweden)

    Arbain Joesoef

    2012-09-01

    Full Text Available A filariasis survey was conducted in Saukorem and Wefiani, Manokwari Regency, Irian Jaya, Indonesia, in October 1982. A total of 366 persons in Sau korem and 228 persons in Wefiani was examined. The infection rates of persons in these two surveyed areas were 20.5% and 20.6% and the intensity of infection were 18.75 and 14.79 respectively. The youngest found infected was an eight months old boy. The prevalence of microfilaraemia tended to increase with age and the prevalence in male was higher than female. The highest count of microfilariae was 659 per 20 mm3 blood sample. All microfilariae were identified as nocturnally periodic Wuchereria ban crofti with the periodicity index of 103.09.Twelve persons were found with symptoms of elephan­tiasis of legs, 3 persons with elephantiasis of legs and arms, 5 persons with elephantiasis of scrotum and one person with elephantiasis of legs and scrotum. The only mosquito vector identified in the surveyed area was Anopheles farauti.

  4. Un anello per domarli tutti

    CERN Document Server

    Merlini, Antonio

    2014-01-01

    Questa tesina tratta degli acceleratori di particelle. I motivi della loro nascita, la loro evoluzione, il loro presente e il loro futuro. Particolare attenzione sarà data al Large Hadron Collider, il più grande di essi e la più incredibile macchina mai realizzata dall’uomo. Inoltre si parlerà dei rilevatori, che permettono lo studio di particelle invisibili all’uomo; del fatto che gli scienziati non escludono che gli strumenti che utilizzano possano potenzialmente distruggere il pianeta; e di come gli acceleratori hanno cambiato la nostra vita.

  5. Un incontro ravvicinato con un uomo di mafia

    Directory of Open Access Journals (Sweden)

    Elena Giordano

    2015-07-01

    Full Text Available Partiamo con una precisazione. Nella letteratura di Mafia esistono vari scritti e testimonianze, ma tra libri, conversazioni e reportage, chi è del mestiere lo sa, una cosa manca: un’intervista a un mafioso NON pentito. Un non pentito non parla, è una regola, “non siamo al servizio della Polizia” e per noi cronisti è anche impossibile ricevere autorizzazioni per avvicinarne qualcuno in carcere. È così che è iniziata la nostra “prova” d’intervista. Franco S. ha a cuore solo due argomenti da affrontare: l’uso delle intercettazioni e dei pentiti.

  6. L'evolució del cervell humà: des d'Homo erectus a Homo sapiens

    OpenAIRE

    Coma Almenar, Herena

    2017-01-01

    Homo sapiens presenta unes característiques morfològiques cerebrals que han possibilitat les capacitats cognitives que podem observar actualment. Però no ha estat a causa d'un fet puntual en la nostra historia evolutiva, sinó que anys de canvis en la dotació genètica i l'adaptació a l'entorn ha procurat el nostre augment del volum encefàlic i de la seva reorganització i connectivitat, on la asimetria cerebral ha estat l'estratègia per optimitzar els recursos neuronals. No obstant, en el regis...

  7. El potencial didáctic de la indumentaria en l’ensenyament de les ciencies socials i del patrimoni

    OpenAIRE

    Llonch Molina, Nayra

    2010-01-01

    La indumentària com a objecte d’anàlisi proporciona informacions importants per a l’estudi de la Historia. Amb tot, la indumentaria proporciona també les bases per a fonamentar una línia didáctica eficient basada en la idea que els vestits son elements que mostren sobretot els efectes dels canvis i de les continuitats. La nostra recerca, iniciada al 2006, en el si del grup de recerca consolidat DIDPATRI (Didàctica del patrimoni, noves tecnologies i museografia comprensiva) de la Universitat d...

  8. The web 2.0 Internet: Democratized Internet collaborations in the healthcare sector

    OpenAIRE

    Hughes, Benjamin Alexander Paul

    2010-01-01

    Les col•laboracions democratitzades a Internet, entenent-les com les eines participatives de la xarxa, o la Web 2.0, afecten en l'actualitat a nombrosos aspectes la nostra vida. Els acadèmics destaquen el potencial de la Web 2.0 per millorar l’aprenentatge o la salut, així com el seu continu impacte en sectors com el de la tecnologia de mitjans de comunicació. També plantegen un gran nombre de qüestions importants als professionals i estudiosos. Per exemple, la consideració crítica de la Web ...

  9. Il corpo narratore

    Directory of Open Access Journals (Sweden)

    Ivano Gamelli

    2005-09-01

    Full Text Available Sapere cosa provo attraverso il mio corpo di fronte all’altro mi permette non solo di capire cosa l'altro prova, soprattutto di generare naturalmente un’effettiva sintonizzazione, di evidenziare e nominare emozioni e sentimenti che in-formano la relazione con quel particolare bambino, adolescente o adulto che sia. Il rapporto con il linguaggio del corpo, prima ancora di divenire pratica psicopedagogica, è una 'pedagogia dell'esistenza'. Una pratica della nostra quotidianità che possiamo affinare oltre e prima che essa diventi pratica psicopedagogica.

  10. Equazione di Dirac

    CERN Document Server

    Monti, Dalida

    1996-01-01

    Relativamente poco noto al gran pubblico, il premio Nobel Paul Adrien Maurice Dirac appartiene a quel gruppo di uomini di ingegno che nei primi decenni del secolo contribuirono a dare alla nostra concezione del mondo fisico la sua impronta attuale. Assolutamente cruciali, per una valutazione dell'opera di Dirac, sono gli anni compresi tra il 1925 e il 1931: un periodo in cui il fisico fornisce la prima spiegazione chiara e coerente delle proprietà di spin dell'elettrone (equazione di Dirac) e perviene, in forza della pura deduzione matematica, alla scoperta dell'esistenza dell'elettrone positivo o positrone.

  11. Identidad cultural y paisaje construido. Proyecto piloto para la restauración de casas tradicionales en el Rincón de Ademuz (Valencia

    Directory of Open Access Journals (Sweden)

    Fernando Vegas

    2005-12-01

    Full Text Available La distinción otorgada en la última convocatoria de los premios Europa Nostra 2003 a un proyecto piloto para la recuperación de las casas tradicionales de una comarca valenciana remota e ignorada, ha elevado el patrimonio de la arquitectura vernácula a la misma cota de valoración que otros grandes monumentos europeos. A continuación, se presentan los antecedentes, planteamiento general del proyecto premiado, soluciones concretas, viabilidad económica y primeras acciones de restauración emprendidas en la rehabilitación de esta arquitectura planteada desde su propia esencia constructiva y estructural.

  12. Learning from las Cuencas

    DEFF Research Database (Denmark)

    2016-01-01

    Aprendiendo de las Cuencas (Learning from las Cuencas) research project, awarded with the EU Prize for Cultural Heritage / Europa Nostra Awards 2015, provides a new perspective of industrial cultural landscapes. Despite being focused on a local environment, the coal mining area of the Cuencas...... economic and social structures came to host busy urban agglomerations of unexpected density in their very heart. This heretical urban configuration is equally the result of the impact of economic interests in a specific space and in a relatively short lapse of time. Consequently, the co...

  13. Cómo Don Quijote viajó a las Américas. Metamorfosis del héroe nacional de España en textos de Rubén Darío, Carlos Fuentes y Kathy Acker

    OpenAIRE

    Sturm-trigonakis, Elke

    2011-01-01

    Only a few fictional heroes symbolize a supposed national character in the way Cervantes’ Don Quijote does in the case of Spain. His adaptation to the ethnic, historical and cultural contexts of the Americas is discussed in this paper, focusing especially on the mechanisms of transtextualization in the short story D. Q. by Rubén Darío (1899), in Terra Nostra by Carlos Fuentes (1975), and in Kathy Acker’s «post-feminist» novel Don Quixote which was a dream from 1986. These three texts demonstr...

  14. Puellae Doctae en las cortes peninsulares

    OpenAIRE

    Borreguero Beltrán, Cristina

    2011-01-01

    El número que el lector té a les mans inclou un dossier, tal com fa darrerament la nostra publicació, en aquest cas dedicat a estudiar les telenovel·les catalanes. També, com és de consuetud, s'hi afegeixen quatre articles que qualifiquem de miscel·lanis i que tracten sobre diferents aspectes de la recerca comunicativa actual. El dossier que ha coordinat Joana Gallego tracta sobre les telenovel·les catalanes, tema que, al nostre entendre, presenta una importància significativa, segons subratl...

  15. Declaration on the sexual and reproductive health in adolescence

    OpenAIRE

    Casado, María

    2002-01-01

    El grup ha analitzat els problemes existents quant a la salut sexual i reproductiva en l'adolescència i la validesa del consentiment informat dels menors. Aquesta qüestió requereix un debat social informat, encaminat a assolir el consens suficient per portar a terme les actuacions necessàries -d'acord amb la normativa ja existent per a la majoria dels supòsits- que protegeixin l'interès del menor, considerat en la nostra legislació com sempre preferent.

  16. L'Universo alla ricerca delle sue origini

    CERN Document Server

    Picasso, Emilio

    2000-01-01

    Sommario : La Cosmologia è una disciplina storica e come avviene per la storia più si allontana dalla nostra epoca il periodo che vogliamo studiare più rari si fanno i documenti e più difficile è l'interpretazione. Il grande anello di collisione elettrone-positrone, il LEP, permette ai fisici di risalire indietro nel tempo e di studiare i fenomeni che sono avvenuti circa un decimo di miliardesimo dopo il Big Bang. In questo senso limitato il LEP è una finestra sul tempo. In questa conferenza sono brevemente presentati gli argomenti di cosmologia e le costruzione del LEP è descritta in dettaglio.

  17. Fundamentos del derecho sancionador tributario

    OpenAIRE

    Sánchez Gervilla, Antonio,

    2017-01-01

    Es podria afirmar que el Dret sancionador administratiu, i per tant el Dret sancionador tributari, és una de les branques del Dret que més controvèrsia ha generat des de la seva gènesi; bona prova d'això la podem trobar en la seva evolució històrica, atenent al fet que aquest va evolucionar des del inicialment denominat Dret penal de policia, passant pel Dret penal administratiu, el Dret penal de l'ordre, fins arribar a l'actual Dret sancionador administratiu. En la nostra opin...

  18. Identità e métissage: umani al di là delle appartenenze (François Laplantine

    Directory of Open Access Journals (Sweden)

    Carlo Milani

    2004-12-01

    Full Text Available Questo breve saggio attacca l'identità e la rappresentazione in quanto nozioni epistemologicamente povere, falsamente realiste, politicamente reazionarie. La nostra epoca di "incertezza identitaria", di "perdita dell'identità" è, secondo Laplantine, il momento migliore per spazzare via questi due dinosauri concettuali, retaggio della metafisica platonica e medievale, e riscoprire la ricchezza del diverso, dell'incontro con l'altro. L'autore cerca di dimostrare l'inconsistenza e l'inutilità ai fini della ricerca nelle scienze sociali, e nell'antropologia in particolare, di identità e rappresentazione, proponendo di sostituirle con la nozione di métissage, meticciato.

  19. Una proposta d'anàlisi de la formalitat disfàsica a partir d'un capítol del "Flos sanctorum"

    Directory of Open Access Journals (Sweden)

    Antoni Mas i Miralles

    2014-02-01

    primers capítols de la "Vida de sant Vicent Ferrer" de Miquel Peres. Com que es tracta d’una traducció al català i d’una obra religiosa, sempre s’havia considerat que era un text de formalitat baixa. Però la nostra anàlisi, tant lingüística com formal, contradiu plenament aquesta suposició, ja que segons els nostres resultats es tracta d’una obra d’una elevada formalitat diafàsica tot i tractar-se d’una traducció del llatí.

  20. Figure del desiderio: l'amore fra distruzione e sublime

    Directory of Open Access Journals (Sweden)

    Mabel Franzone

    2005-03-01

    Full Text Available Attraverso due racconti di Cortázar, l'analisi di due figure del desiderio ci permette esplorare due estremi seguendo una verticalità. La distruzione, doppio tenebroso della nostra anima, ci rivela un erotismo legato alla morte e al desiderio morboso di possedere l'Altro; il suo contraltare è un'ascesa vertiginosa accompagnata da un godimento estetico, dall'amore sublime prossimo all'esperienza mistica che si concluderà con una discesa progressiva e nel rispetto di questo Altro. La creazione letteraria si presenta come uno sfogo alle nostre angosce, che sono anche una sorta d'espressione dell'erotismo.

  1. Dal Conte di Montecristo ai Promessi Sposi (passando per Melissa): l’Italia all’ombra degli sceneggiati Rai

    OpenAIRE

    Campanile, Achille; Rodari, Gianni; Cipriani, Ivano

    2016-01-01

    Come Gianluigi Rossini spiega nel libro Le serie TV, e come questo numero illustra, le tante diverse forme di serialità narrativa hanno via via creato tante diverse forme di dipendenza. Ma una delle più memorabili resta quella innescata dai cosiddetti “sceneggiati” che la nostra Rai manda in onda tra gli anni Cinquanta e i Settanta, dipendenza vissuta pressoché da tutti con la stessa assolutezza, cerimonia laica, passione (e non di rado ossessione) condivisa negli stessi tempi e modi: non sol...

  2. Social software e multitasking: un virus o una risorsa?

    Directory of Open Access Journals (Sweden)

    Gisella Paoletti

    2013-03-01

    Full Text Available Il multitasking è una strategia di gestione delle risorse cognitive; consiste nello svolgere più di un compito contemporaneamente. In alcuni casi è inevitabile, altre volte no, ma sempre più spesso ci sentiamo costretti a cercare di fare più cose simultaneamente. Possiamo veramente dividere la nostra attenzione conscia tra due compiti impegnativi, come leggere e scrivere? In questo articolo si riportano risultati sperimentali che hanno dimostrato che il risparmio di tempo può essere illusorio e che la performance ha un decadimento rispetto alle situazioni in cui è possibile svolgere i compiti in sequenza.

  3. Zoper

    OpenAIRE

    González Burgos, Ismael

    2016-01-01

    La idea principal és fer un joc semblant a l'antic Zoop. La història d'aquest joc és bastant senzilla: es tracta d'evitar que els enemics o fitxes arribin fins al centre del tauler on es troba la nostra fitxa, que és el que controlarem al joc. El joc ha estat desenvolupat en C++ amb SFML. La idea principal es hacer un juego parecido al antiguo Zoop. La historia de este juego es bastante sencilla: se trata de evitar que los enemigos o fichas lleguen hasta el centro del tablero donde se encu...

  4. Evaluación de los factores epidemiológicos como predictores de los resultados postquirúrgicos en patología lumbar degenerativa

    OpenAIRE

    Lozano Álvarez, Carlos

    2011-01-01

    Els resultats del tractament quirúrgic per dolor lumbar crònic i patologia degenerativa lumbar, patologies d'elevada prevalença i despesa sanitària, estan afectats per múltiples factors. En aquest treball hem estudiat com les característiques epidemiològiques dels pacients de la nostra població influeixen sobre el canvi de la qualitat de vida, la discapacitat i el dolor després de cirurgies per patologia lumbar degenerativa. Del nostre estudi, d'acord amb la revisió realitzada de la literatur...

  5. Editorial

    Directory of Open Access Journals (Sweden)

    Agustí Cerrillo

    2013-06-01

    Full Text Available

    A l’empara d’internet i de les xarxes socials o les xarxes d’intercanvi d’arxius van sorgint formes noves de delinqüència que exigeixen mecanismes nous tant de prevenció com de repressió. El farming, el phishing i, més recentment, el cyberbulling són conductes delictives que han aflorat i es van estenent al ritme que ho fa l’ús d’internet en la nostra societat.

  6. Editorial

    OpenAIRE

    Cerrillo, Agustí

    2013-01-01

    A l’empara d’internet i de les xarxes socials o les xarxes d’intercanvi d’arxius van sorgint formes noves de delinqüència que exigeixen mecanismes nous tant de prevenció com de repressió. El farming, el phishing i, més recentment, el cyberbulling són conductes delictives que han aflorat i es van estenent al ritme que ho fa l’ús d’internet en la nostra societat.

    ...

  7. A theoretical approach to the engineering of bioinspired systems: design, applications & information management

    OpenAIRE

    Revilla López, Guillem

    2011-01-01

    Premi extraordinari doctorat curs 2010-2011, àmbit d’Enginyeria Enginyeria Industrial L’enginyeria de sistemes bioinspirats ha crescut en importància i nombre d’aplicacions en el últims anys, atraient l’atenció dels científics sobre els seus usos potencials en camps com ara la bionanotecnologia, la nanomedicina i la ciència de materials. En aquesta tesis, es presenta una aproximació mitjançant mètodes computacionals a l’enginyeria de sistemes biomimètics. Em posat la nostra èm...

  8. Le costruzioni percettive-letterarie del corpo: verso una psicobiologia letteraria del Sé di Alfonso Santarpia.

    OpenAIRE

    Santarpia, Alfonso

    2014-01-01

    International audience; Il visuale organico sembra promettere di svelare i segreti di quando pensiamo, di quando lottiamo, di quando amiamo e perché no, si saprà a breve anche quale area funzionale dell'encefalo si accen-derà o si spegnerà nell'attesa della morte. Plurime cartografie della nostra cognizione si svelano agli occhi degli scienziati (Damasio, 1995, 1999). Ma se un paziente fortemente ansioso vi racconta : ho gli occhi stanchi, lo stomaco mi brucia, il mio cervello ruota veloce co...

  9. Aprendiendo de las Cuencas

    DEFF Research Database (Denmark)

    2016-01-01

    Aprendiendo de las Cuencas (Learning from las Cuencas) research project, awarded with the EU Prize for Cultural Heritage / Europa Nostra Awards 2015, provides a new perspective of industrial cultural landscapes. Despite being focused on a local environment, the coal mining area of the Cuencas....... This has given rise to incredibly heterodox building patterns that contain the conflict on which they are erected embedded in their genetic code. These are hybrid architectures, mutating artefacts which, despite the invisibility of their inevitable marginality, can offer really interesting lessons...

  10. Niche acclimatization in Red Sea corals is dependent on flexibility of host-symbiont association

    KAUST Repository

    Ziegler, Maren

    2015-08-06

    Knowledge of host-symbiont specificity and acclimatization capacity of corals is crucial for understanding implications of environmental change. Whilst some corals have been shown to associate with a number of symbionts that may comprise different physiologies, most corals associate with only one dominant Symbiodinium species at a time. Coral communities in the Red Sea thrive under large fluctuations of environmental conditions, but the degree and mechanisms of coral acclimatization are largely unexplored. Here we investigated the potential for niche acclimatization in 2 dominant corals from the central Red Sea, Pocillopora verrucosa and Porites lutea, in relation to the fidelity of the underlying coral-symbiont association. Repeated sampling over 2 seasons along a cross-shelf and depth gradient revealed a stable symbiont association in P. verrucosa and flexible association in P. lutea. A statistical biological-environmental matching routine revealed that the high plasticity of photophysiology and photopigments in the stable Symbiodinium microadriaticum (type A1) community in P. verrucosa were correlated with environmental influences along spatio-temporal dimensions. In contrast, photophysiology and pigments were less variable within each symbiont type from P. lutea indicating that niche acclimatization was rather regulated by a flexible association with a variable Symbiodinium community. Based on these data, we advocate an extended concept of phenotypic plasticity of the coral holobiont, in which the scleractinian host either associates with a specific Symbiodinium type with a broad physiological tolerance, or the host-symbiont pairing is more flexible to accommodate for different symbiont associations, each adapted to specific environmental settings.

  11. Niche acclimatization in Red Sea corals is dependent on flexibility of host-symbiont association

    KAUST Repository

    Ziegler, Maren; Roder, Cornelia; Bü chel, C; Voolstra, Christian R.

    2015-01-01

    Knowledge of host-symbiont specificity and acclimatization capacity of corals is crucial for understanding implications of environmental change. Whilst some corals have been shown to associate with a number of symbionts that may comprise different physiologies, most corals associate with only one dominant Symbiodinium species at a time. Coral communities in the Red Sea thrive under large fluctuations of environmental conditions, but the degree and mechanisms of coral acclimatization are largely unexplored. Here we investigated the potential for niche acclimatization in 2 dominant corals from the central Red Sea, Pocillopora verrucosa and Porites lutea, in relation to the fidelity of the underlying coral-symbiont association. Repeated sampling over 2 seasons along a cross-shelf and depth gradient revealed a stable symbiont association in P. verrucosa and flexible association in P. lutea. A statistical biological-environmental matching routine revealed that the high plasticity of photophysiology and photopigments in the stable Symbiodinium microadriaticum (type A1) community in P. verrucosa were correlated with environmental influences along spatio-temporal dimensions. In contrast, photophysiology and pigments were less variable within each symbiont type from P. lutea indicating that niche acclimatization was rather regulated by a flexible association with a variable Symbiodinium community. Based on these data, we advocate an extended concept of phenotypic plasticity of the coral holobiont, in which the scleractinian host either associates with a specific Symbiodinium type with a broad physiological tolerance, or the host-symbiont pairing is more flexible to accommodate for different symbiont associations, each adapted to specific environmental settings.

  12. Die ontstaan en ontwikkeling van melaatsheid in die antieke tyd: navorsings - en oorsigartikels

    Directory of Open Access Journals (Sweden)

    François Retief

    2009-09-01

    millennium BC, and possibly in India and China in the 1st millennium BC. It has been suggested that leprosy was brought to the Mediterranean region by Alexander the Great’s armies, 4th century BC.Leprosy produces pathognomonic bone lesions, and the earliest osteo-archaeological evidence of leprosy was found in Egyptian skulls dating back to the 2nd century BC. The first clinical description of a disease recognisable as classical leprosy, can be dated to Strato of Alexandria, 3rd century BC. This condition, which became known as elephantiasis or elephas, was subsequently described by numerous notable physicians of the time, and Aretaeus of Cappadocia in particular. It migrated to Greece and Italy; Pliny the Elder stating that it fi rst appeared in Rome at the end of the 1st century BC. Although it was considered incurable, complex therapeutic programmes including venesection, purges, enemas and perspirants were prescribed in order to rid the body of the presumed fluid retention. Elephantiasis spread through the Roman Empire, but only became a notable European epidemic during the Middle Ages. In time the zara’ath-associated lepra of the Septuagint and elephantiasis were considered related diseases, and by the 4th century they were seen as the same disease. The two names became interchangeable. The influence of the Christian Church was such that the ritualised banning of lepers became incorporated into the treatment of elephantiasis – against the advice of physicians like Caelius Aurelianus (4th/5th century AD. Gradually the name lepra (leprosy replaced elephantiasis, which ensured the stigmatisation of leprosy as an “unclean disease” with divine punishment for previous sins – a tragic misconception which persisted up to modern times. Today elephantiasis refers to a tropical parasitic disease, fi lariasis, characterised by gross swelling and deformation of the lower body.

  13. About inclusions found in erythrocytes of some lizards (Lacertilia - sp) A new Bartonella?

    OpenAIRE

    Weiss, Pedro

    2014-01-01

    Suggestibility by the widespread belief among the inhabitants of some warty and utosas areas involving a reptile in the cycle of these diseases, I have tried repeatedly to examine the blood of animals in such order, both in endemic areas and in other places. Sugestionado por la creencia muy extendida entre los habitantes de algunas zonas verrucosas y utosas de la participación de un reptil en el ciclo de estas enfermedades, he procurado en repetidas ocasiones examinar la sangre de animales...

  14. Pollen analysis in honey samples from the two main producing regions in the Brazilian northeast

    Directory of Open Access Journals (Sweden)

    Geni da S. Sodré

    2007-09-01

    Full Text Available Knowledge about the botanical source of honey is very important for the beekeeper while it indicates adequate and abundant supply sources of nectar and pollen for the bees, thus contributing toward improved yield. The present study means to identify the pollen types occurring in 58 samples of honey produced in two states of the northeastern region of Brazil, Piauí (38 samples and Ceará (20 samples, and to verify the potential of the honey plants during the months of February to August. The samples were obtained directly from beekeepers in each state and analyzed at the Apiculture Laboratory of the Entomology Section of Escola Superior de Agricultura "Luiz de Queiroz", USP, Piracicaba, State of São Paulo, Brazil. The pollen analysis was performed using the acetolysis method. The samples were submitted to both a qualitative and a quantitative analysis. The dominant pollen in the State of Ceará is from Mimosa caesalpiniaefolia, M. verrucosa, Borreria verticillata, Serjania sp., and a Fabaceae pollen type, while in the State of Piauí it is from Piptadenia sp., M. caesalpiniaefolia, M. verrucosa, Croton urucurana and Tibouchina sp.O conhecimento da origem botânica do mel é de grande importância para o apicultor por indicar fontes adequadas e de abundante suprimento de néctar e pólen para as abelhas, contribuindo, desta forma, para uma melhor produção. O presente estudo teve como objetivo identificar os tipos polínicos em 58 amostras de méis produzidos em dois estados da região nordeste do Brasil, Piauí (38 amostras e Ceará (20 amostras, verificando o potencial das plantas apícolas durante os meses de fevereiro a agosto. As amostras foram obtidas diretamente de apicultores de cada Estado e analisadas no Laboratório de Apicultura do Setor de Entomologia da Escola Superior de Agricultura "Luiz de Queiroz", USP, Piracicaba, Estado de São Paulo. A análise polínica foi realizada utilizando-se o método da acetólise. As amostras foram

  15. New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae.

    Science.gov (United States)

    Pullen, Christian; Schmitz, Petra; Meurer, Kristina; Bamberg, Daniel D v; Lohmann, Stephanie; De Castro França, Suzelei; Groth, Ingrid; Schlegel, Brigitte; Möllmann, Ute; Gollmick, Friedrich; Gräfe, Udo; Leistner, Eckhard

    2002-11-01

    Wood from three different plants of the Celastraceae growing in their natural habitats in Brazil (Maytenus aquifolia Mart.) and South Africa [Putterlickia retrospinosa van Wyk and Mostert, P. verrucosa (E. Meyer ex Sonder) Szyszyl.] was established as a source of endophytic bacteria using a medium selective for actinomycetes. Two isolates were identified as Streptomyces setonii and S. sampsonii whereas two others were not assignable to any of the known Streptomyces species. They were preliminarily named Streptomyces Q21 and Streptomyces MaB-QuH-8. The latter strain produces a new chloropyrrol and chlorinated anthracyclinone. The chloropyrrol showed high activity against a series of multiresistent bacteria and mycobacteria.

  16. COMPARATIVE STUDY OF FILARIAL DETECTION BY MICROSCOPIC EXAMINATION AND SEROLOGICAL ASSAY UTILIZING BMR1 AND BMXSP RECOMBINANT ANTIGENS FOR EVALUATION OF FILARIASIS ELIMINATION PROGRAM AT KAMPUNG SAWAH AND PAMULANG, SOUTH TANGERANG DISTRICT, BANTEN, INDONESIA

    Directory of Open Access Journals (Sweden)

    Silvia F. Nasution

    2015-09-01

    Full Text Available South Tangerang district is one of the endemic areas for filariasis; and based on an evaluation study in 2008-2009 which covered several subdistricts, the prevalence of microfilaria was between 1–2.4%. Nevertheless, the evaluation by serological assay has never been reported. A cross-sectional study was conducted to detect the microfilaremia and anti-filarial IgG4 antibody status in Kp Sawah and Pamulang subdistricts. Cluster sampling was performed in Kp Sawah by collecting finger-prick blood (FPB and venous blood samples from inhabitants who lived with and nearby the four elephantiasis subjects in the area. The FPB were only collected in Pamulang area by consecutive sampling method. The detection method included microscopic evaluation of FPB and serological detection using recombinant antigens BmR1 and BmSXP by ELISA and lateral flow rapid tests. Symptomatic patients who had 2nd and 3rd degree of elephantiasis were clinically determined in 10% (4/40 subjects. Among those with elephantiasis, 2 were positive serologically but their microscopic results were all negative (40/40. Meanwhile, the microscopic result for 107 subjects from Pamulang were all negative. The results of the rapid tests showed that 15% (6/40 of the positive cases were detected by Brugia Rapid and 27.5% (11/40 by PanLF. Meanwhile, the ELISA showed that 20% (8/40 of the cases were positive with BmSXP, whereas only 2.5% or 1/40 sample was found to be positive with BmR1. Even though the sensitivity of the Rapid test was lower when compared to microscopic examination for these samples, the assay showed good specificity ranging from 72.5 to 97.5%. The optical density (OD values of ELISA has ranged between 0.3–3.045.

  17. Delayed complications of surgical and combined therapy of mammary gland cancer

    International Nuclear Information System (INIS)

    Selivanov, I.S.; Bardychev, M.S.

    1984-01-01

    Analysis of complications of surgical and combined (operation+radiotherapy) treatment of 114 patients is carried out. 2-8 years after the treatment various complications were detected in 82 (72.0%) patients, 45(39.6%) of them complained of pains in the arm, 20(17.6%) had limitations of humeral articulation, and 78(68.5%) suffered from upper extremity edema and elephantiasis. The number of complications increased in patients who have undergone radiotherapy and in patients with excessive body mass

  18. Delayed complications of surgical and combined therapy of mammary gland cancer

    Energy Technology Data Exchange (ETDEWEB)

    Selivanov, I.S.; Bardychev, M.S. (Akademiya Meditsinskikh Nauk SSSR, Obninsk. Nauchno-Issledovatel' skij Inst. Meditsinskoj Radiologii)

    1984-01-01

    Analysis of complications of surgical and combined (operation+radiotherapy) treatment of 114 patients is carried out. 2-8 years after the treatment various complications were detected in 82 (72.0%) patients, 45 (39.6%) of them complained of pains in the arm, 20 (17.6%) had limitations of humeral articulation, and 78 (68.5%) suffered from upper extremity edema and elephantiasis. The number of complications increased in patients who have undergone radiotherapy and in patients with excessive body mass.

  19. A clinical and investigational study of donovanosis

    Directory of Open Access Journals (Sweden)

    Veeranna S

    2003-03-01

    Full Text Available A clinical and investigational study of 25 cases of Donovanosis was undertaken. The incidence was found to be 1.53% of all STD cases and 2.9% of GUD. M:F ratio was 2.12:1. Incidence was more in unmarried people. Fleshy exuberant type was seen in 88% of cases. Two patients (8% had extragenital ulcers. Donovan bodies were found in 88%. Pseudo elephantiasis was seen in 8 patients. Biopsy was done in 8 cases and showed ocanthosis, plasma cell infiltration and pseudo epitheliomatous hyperplasia. One patient developed squamous cell carcinoma of vulva.

  20. [Podoconiosis, a society and medical community neglected disease].

    Science.gov (United States)

    Prieto-Pérez, Laura; Soriano Cea, Juan José; Górgolas Hernández-Mora, Miguel

    2015-11-20

    Podoconiosis, mossy foot or endemic non-filarial elephantiasis, is a geochemical disease that causes lower limb lymphedema; it is directly related to walking barefoot over soils of volcanic origin, in areas with a high pluviometric annual index. It has a specific geographical distribution, affecting around 5% population in areas where it is endemic. It is debilitating and disfiguring disease, which frequently leads to social margination. Podoconiosis is totally preventable and, once a diagnosis is established, it may improve with simple therapeutic measures. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

  1. An Unusual Gross Appearance of Vulval Tuberculosis Masquerading as Tumor

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    Surekha U. Arakeri

    2014-01-01

    Full Text Available Tuberculosis of the vulva is very rare. It is found in about 0.2% of the cases of genital tract tuberculosis. It usually presents as small shallow ulcers and multiple sinus tracts or rarely as elephantiasis of vulva. Except for very rare cases of primary tuberculosis in the vulva, it is usually associated with tuberculosis elsewhere in the body leading to secondary tuberculosis. Here, we report a case of secondary vulval tuberculosis which presented as a vulval mass in a 40-year-old female patient. The rarity of this presentation in the female genital tract is emphasized.

  2. An unusual gross appearance of vulval tuberculosis masquerading as tumor.

    Science.gov (United States)

    Arakeri, Surekha U; Sinkar, Prachi

    2014-01-01

    Tuberculosis of the vulva is very rare. It is found in about 0.2% of the cases of genital tract tuberculosis. It usually presents as small shallow ulcers and multiple sinus tracts or rarely as elephantiasis of vulva. Except for very rare cases of primary tuberculosis in the vulva, it is usually associated with tuberculosis elsewhere in the body leading to secondary tuberculosis. Here, we report a case of secondary vulval tuberculosis which presented as a vulval mass in a 40-year-old female patient. The rarity of this presentation in the female genital tract is emphasized.

  3. L’arcipelago postmoderno. Oreste del Buono e gli anni Settanta

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    Andrea Chiurato

    2012-12-01

    Il tentativo di cooptazione postuma tra le file dei simpatizzanti da parte del Gruppo 63 avrà breve fortuna (verrà incluso nella prima antologia del gruppo, ma non nelle se-guenti, e Renato Barilli arriverà addirittura a porlo a capo di un improbabile «Polo Bu-tor» (Chiurato 14, uno sparuto gruppo di „infiltrati‟ (insieme a Raffaele La Capria, Emilio Tadini, e Giuliano Gramigna nelle file della compagine neoavanguardista. Quarant‟anni dopo la questione rimane aperta e l‟eredità di quel turbolento periodo è ancora oggetto di discussione. La nostra intenzione è proporre un approccio diverso, che cer-chi di restituire la fluidità e la ricchezza delle suggestioni di allora poi irrigiditesi in cate-gorie critiche spesso frutto di semplificazioni indebite. Del Buono, irriducibile outsider, ci permette così di riscoprire gli anni Settanta da un‟angolazione inedita e di colmare, nello stesso tempo, alcune improvvide lacune nella nostra memoria culturale

  4. WITTGENSTEIN AND PHILOSOPHICAL SPIRITUALITY IN THE LIGHT OF THE LECTURE ON ETHICS

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    Tommaso Manzon

    2016-03-01

    Full Text Available Lo scopo di questo paper è quello di sviluppare una lettura e un’interpretazione di uno degli scritti “minori” di Ludwig Wittgenstein, la Conferenza sull’Etica. La mia comprensione della Conferenza è inspirata principalmente dall’interpretazione della filosofia di Wittgenstein sviluppata da Pierre Hadot e, di conseguenza, la mia tesi consisterà nel dimostrare che seguendo Hadot la Conferenza sull’Etica può essere vista come un ‘Esercizio Spirituale’. Pertanto sostengo che la finalità principale di questo scritto va vista nel tentativo di cambiare la nostra attitudine verso il mondo, e dunque la nostra disposizione etica verso di esso. Ritengo inoltre che questo non sia solo lo scopo di ogni Esercizio Spirituale, bensì in generale quello dell’attività del filosofo austriaco, ossia, la volontà di coinvolgere i propri destinatari provocando in loro una riflessione e possibilmente un cambiamento in merito al proprio modo di vivere, e a tutta la sfera che va sotto il nome di “Etica”.

  5. Il mondo dentro il mondo

    CERN Document Server

    Barrow, John D

    1991-01-01

    Davvero esistono “lì fuori” leggi di natura, che stanno in attesa di essere scoperte, indipendenti dal nostro modo di pensare, o esse rappresentano soltanto la descrizione più conveniente di ciò che abbiamo visto? Come è nata l’idea stessa di “leggi di natura”? Queste costituiscono la realtà profonda o sono soltanto pezzi di un regolamento che ci siamo dati per organizzare meglio la nostra conoscenza del mondo? o semplici paletti che piantiamo e ci lasciamo alle spalle come segnali via via che procediamo nella giungla dell’esperienza? È possibile che non esistano affatto leggi di natura? Forse esse, e anche l’universo che da esse sembra regolato, sono del tutto creazioni della nostra mente: un’illusione che scompare appena cessiamo di pensarvi. Ma allora, che cosa accadrebbe, se non ci fossero osservatori dell’universo?». Interrogativi di questo genere, che incontriamo sulla soglia del Mondo dentro il mondo, sarebbero suonati eccentrici fino a qualche anno fa. Oggi, al contrario, circ...

  6. Cercare mondi esplorazioni avventurose ai confini dell'universo

    CERN Document Server

    Tonelli, Guido

    2017-01-01

    Abitiamo un sottile guscio sferico, di pochi chilometri di spessore, intorno alla superficie della Terra. Anche se esploriamo gli abissi più profondi dell'oceano o scaliamo le vette dell'Himalaya, il nostro regno ha dimensioni ridicole. Per questo, se riflettiamo su quelle dell'universo, ci resta una sensazione di lieve sgomento. Non solo. Il nostro piccolo mondo è anche popolato di chimere, fantasmi e terribili inganni: pensiamo che quello che percepiamo sia reale, invece tutto cambia appena ci allontaniamo dall'angolo tranquillo in cui si svolge la nostra esistenza. Quando cerchiamo di capire i fenomeni che si osservano nel meraviglioso tappeto di galassie che ricopre la volta stellata, o quelli che caratterizzano la materia nei suoi componenti elementari, dobbiamo rinunciare alle certezze che governano la nostra vita e intraprendere un viaggio vertiginoso che lascia senza fiato. Guido Tonelli, fisico al Cern di Ginevra e uno dei padri della scoperta del bosone di Higgs, ci fa compiere questo viaggio irri...

  7. I desideri e le masse. Una riflessione sul presente

    Directory of Open Access Journals (Sweden)

    Guido Mazzoni

    2013-08-01

    Full Text Available Negli ultimi quarantacinque anni la vita psichica delle masse occidentali ha subito una metamorfosi senza precedenti; noi tutti ne siamo stati trasformati e travolti. Fedele a un’idea eroica e maschile dell’accadere e dell’esperienza, all’idea che le rotture epocali si manifestino sotto forma di guerre e rivoluzioni, una parte della cultura contemporanea continua a sottovalutare la portata di quanto è avvenuto. È una miopia che si manifesta talvolta in forma esplicita e più spesso in forma implicita, come accade ogni volta che applichiamo alla nostra epoca concetti, parole e miti che non reggono più. Molte delle categorie con cui giudichiamo il presente, con cui prendiamo una posizione etico-politica sui problemi della nostra epoca, danno l’impressione di scivolare sulla realtà senza afferrarla, o perché fanno riferimento a un futuro che, non rimandando più a un progetto politico, rappresenta solo la proiezione di un desiderio, o perché fanno riferimento a un passato che non ritornerà. Quali sono i tratti più vistosi della metamorfosi? Che cosa è accaduto?

  8. UDI STOP Femminicidio

    Directory of Open Access Journals (Sweden)

    Giovanna Crivelli

    2014-04-01

    Full Text Available L'UDI, Unione Donne in Italia, ha collaborato con l'Osservatorio dei Processi Comunicativi a un numero monografico della rivista scientifica M@gm@ dal titolo "Violenza maschile e femminicidio". Il numero monografico vuole mettere a disposizione le analisi, l’esperienza e la storia nostra e delle nostre interlocutrici, come contributo al nostro comune lavoro di sensibilizzazione, contrasto alla violenza maschile sulle donne – femminicidio. “UDI STOP femminicidio” è da anni la nostra campagna contro la violenza di genere, la collaborazione con l’Osservatorio dei Processi Comunicativi è parte integrante di questo sforzo. Il primo e dichiarato dei nostri progetti politici è il contrasto alla cultura e al potere ideologico che consente il femminicidio, la subordinazione culturale e sociale, la percezione della donna come oggetto di dominio, la riduzione in schiavitù di tante donne, comprese molte donne prostitute... Sappiamo di non voler tradire una “responsabilità di genere” che deve necessariamente concretizzarsi in tanti “gesti responsabili”, nella lunga pazienza quotidiana che consente la sedimentazione di un cambiamento radicale nelle coscienze. Vogliamo continuare ad essere l’associazione che coniuga insieme la soggettività personale e l'assunzione diretta di responsabilità, della progettualità a lungo termine che non trova “contraddittorio” misurarsi con la solidarietà concreta e quotidiana con le altre donne, nel tentativo di far nascere le nuove maniere di pensare.

  9. Pollen analysis in honey samples from the two main producing regions in the Brazilian northeast.

    Science.gov (United States)

    Sodré, Geni da S; Marchini, Luís C; Carvalho, Carlos A L de; Moreti, Augusta C de C C

    2007-09-01

    Knowledge about the botanical source of honey is very important for the beekeeper while it indicates adequate and abundant supply sources of nectar and pollen for the bees, thus contributing toward improved yield. The present study means to identify the pollen types occurring in 58 samples of honey produced in two states of the northeastern region of Brazil, Piauí (38 samples) and Ceará (20 samples), and to verify the potential of the honey plants during the months of February to August. The samples were obtained directly from beekeepers in each state and analyzed at the Apiculture Laboratory of the Entomology Section of Escola Superior de Agricultura "Luiz de Queiroz", USP, Piracicaba, State of São Paulo, Brazil. The pollen analysis was performed using the acetolysis method. The samples were submitted to both a qualitative and a quantitative analysis. The dominant pollen in the State of Ceará is from Mimosa caesalpiniaefolia, M. verrucosa, Borreria verticillata, Serjania sp., and a Fabaceae pollen type, while in the State of Piauí it is from Piptadenia sp., M. caesalpiniaefolia, M. verrucosa, Croton urucurana and Tibouchina sp.

  10. Microbial Diversity of Betula Trees: Pollen, Catkins, Leaves Relatively of Flowering

    Directory of Open Access Journals (Sweden)

    Tetiana V. Shevtsova

    2016-01-01

    Full Text Available Quantitative microbiological analysis by dilution plating method of pollen and additional male and female catkins, leaves of Betula verrucosa Ehrh. and its two cultivars: ‘Purpurea’ and ‘Youngii’ relatively of flowering period of Betula has been realized with the aim to provide new knowledge of the microbiological quality of anemophilous pollen for processing and its further application. Qualitative microbiological analysis with MALDI-TOF MS Biotyper was used in the identification of aerobic, anaerobic mesophilic bacteria and coliforms. Mixed microbiota was determined, consisting of aerobic (4.68–4.89 log cfu/g and anaerobic (3.30–3.48 log cfu/g mesophilic bacteria, lactobacilli (0–3.48 log cfu/g, coliform bacteria (0–4.57 log cfu/g, fungi and yeast (3.78–3.95 log cfu/g on the pollen grains, that indicates acceptable quality in comparison with the microbiological quality parameters for bee pollen. Pantoea agglomerans was found associated with pollen of Betula verrucosa Ehrh. Recommendations on the collection of anemophilous pollen were established.

  11. A clinicopathological study of cutaneous tuberculosis at Dibrugarh district, Assam

    Directory of Open Access Journals (Sweden)

    Binod Kumar Thakur

    2012-01-01

    Full Text Available Background: Cutaneous tuberculosis forms a small subset of extra pulmonary tuberculosis and has a worldwide distribution. Aims: The present study is an attempt to find out the incidence, clinical spectrum, and histopathological features of cutaneous tuberculosis. Materials and Methods: A total of 42 cases of newly diagnosed patients of cutaneous tuberculosis attending dermatology out patient department over a period of 1 year were included in the study. A detailed clinical examination and investigations including histopathological examination were carried out. Results: Scrofuloderma was the most common form seen in 50% cases followed by lupus vulgaris in 42.86%, tuberculosis verrucosa cutis in 4.76%, and lichen scrofulosorum in 2.38% cases. The Mantoux test was positive in 83.33% cases. Characteristic tuberculoid granulomas were seen in 72.22% cases of lupus vulgaris, 42.86% cases of scrofuloderma and all cases of tuberculosis verrucosa cutis and lichen scrofulosorum. Conclusion: Cutaneous tuberculosis is still highly prevalent in upper Assam. Early diagnosis and treatment are essential to prevent its complications.

  12. A clinicopathological study of cutaneous tuberculosis at Dibrugarh district, Assam.

    Science.gov (United States)

    Thakur, Binod Kumar; Verma, Shikha; Hazarika, Debeeka

    2012-01-01

    Cutaneous tuberculosis forms a small subset of extra pulmonary tuberculosis and has a worldwide distribution. The present study is an attempt to find out the incidence, clinical spectrum, and histopathological features of cutaneous tuberculosis. A total of 42 cases of newly diagnosed patients of cutaneous tuberculosis attending dermatology out patient department over a period of 1 year were included in the study. A detailed clinical examination and investigations including histopathological examination were carried out. Scrofuloderma was the most common form seen in 50% cases followed by lupus vulgaris in 42.86%, tuberculosis verrucosa cutis in 4.76%, and lichen scrofulosorum in 2.38% cases. The Mantoux test was positive in 83.33% cases. Characteristic tuberculoid granulomas were seen in 72.22% cases of lupus vulgaris, 42.86% cases of scrofuloderma and all cases of tuberculosis verrucosa cutis and lichen scrofulosorum. Cutaneous tuberculosis is still highly prevalent in upper Assam. Early diagnosis and treatment are essential to prevent its complications.

  13. Relationship of Environmental Conditions to Filariasis Cases in Community (An Advanced Analysis of Basic Health Research 2007

    Directory of Open Access Journals (Sweden)

    Santoso

    2011-06-01

    Full Text Available Filariasis (elephantiasis disease in Indonesia is still a health problems, there are still areas with the patient chronic and acute. A total of 1553 villages in 647 health centers scattered in 231 districts in 26 provinces as the location of the endemic, with a number of chronic cases of 6233 people. Elimination program disease elephantiasis has been undertaken by the government, but until today there are still many areas with the number of microfilariae (Mf rate is still high (> 1%. One of the government's efforts in this regard Litbangkes RI in collecting basic data, including data filariasis is with the activities of the Basic Health Research (Riskesdas conducted simultaneously across Indonesia. Based on the results of data collection Riskesdas then further analysis is to look at the environmental conditions and demographic status associated with the incidence of filariasis. Based on the results of analysis show that there were a statistically significant relationship between the type of waste water reservoirs; types of sewage systems and types of livestock kept, the classification of villages with the incidence of filariasis.

  14. Brugia timori INFECTION IN LEKEBAI, FLORES: clinical aspects

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    Arbain Joesoef

    2012-09-01

    Full Text Available Pengamatan filariasis pada penduduk Nualolo-Lekebai, Pulau Flores telah dilakukan pada bulan Februari 1975. Kampung Nualolo-Lekebai berpenduduk 680 jiwa, pekerjaan bertani dan menganut agama Nasrani. Kebiasaan hidup di antara penduduk di daerah ini adalah menyerahkan pelaksanaan pekerjaan berat pada kaum wanita, baik di rumah ataupun di kebun. Dalam perjalanan jauh baik ke kebun atau ke pasar, kaum wanitanya selalu berjalan kaki sedangkan kaum prianya menunggang kuda. Sejumlah 80% dari penduduk kampung ini telah diperiksa terhadap infeksi parasit filaria dan terhadap gejala filariasis. Dari hasil yang ditemukan ternyata penduduk kampung ini menderita infeksi Brugia timori dengan angka derajat infeksi sebesar 7.0% dan angka derajat elephantiasis sebesar 10.3%. Hal yang menarik yang ditemukan dalam pengamatan ini adalah tingginya angka derajat elephantiasis pada kaum wanita dibandingkan dengan pada kaum pria. Fenomena ini mungkin disebabkan oleh kebiasaan hidup kaum wanita di daerah ini sehari-hari yang bekerja lebih berat dan berjalan kaki lebih sering dan lebih jauh dibandingkan kaum prianya.

  15. Filarial excretory-secretory products induce human monocytes to produce lymphangiogenic mediators.

    Directory of Open Access Journals (Sweden)

    Tiffany Weinkopff

    2014-07-01

    Full Text Available The nematodes Wuchereria bancrofti and Brugia spp. infect over 120 million people worldwide, causing lymphedema, elephantiasis and hydrocele, collectively known as lymphatic filariasis. Most infected individuals appear to be asymptomatic, but many exhibit sub-clinical manifestations including the lymphangiectasia that likely contributes to the development of lymphedema and elephantiasis. As adult worm excretory-secretory products (ES do not directly activate lymphatic endothelial cells (LEC, we investigated the role of monocyte/macrophage-derived soluble factors in the development of filarial lymphatic pathology. We analyzed the production of IL-8, IL-6 and VEGF-A by peripheral blood mononuclear cells (PBMC from naïve donors following stimulation with filarial ES products. ES-stimulated PBMCs produced significantly more IL-8, IL-6 and VEGF-A compared to cells cultured in medium alone; CD14(+ monocytes appear to be the primary producers of IL-8 and VEGF-A, but not IL-6. Furthermore, IL-8, IL-6 and VEGF-A induced in vitro tubule formation in LEC Matrigel cultures. Matrigel plugs supplemented with IL-8, IL-6, VEGF-A, or with supernatants from ES-stimulated PBMCs and implanted in vivo stimulated lymphangiogenesis. Collectively, these data support the hypothesis that monocytes/macrophages exposed to filarial ES products may modulate lymphatic function through the secretion of soluble factors that stimulate the vessel growth associated with the pathogenesis of filarial disease.

  16. Coverage and compliance MDA programme for lymphatic filariasis in Bidar district, Karnataka, India

    Directory of Open Access Journals (Sweden)

    Dharukaswami. Mallayya. Koradhanyamath

    2012-08-01

    Full Text Available Objective: To describe the socio demographic characteristics of beneficiaries of the Mass Drug Administration (MDA programme, to assess the coverage, compliance and causes for noncompliance towards MDA in the district, to assess the awareness regarding elephantiasis among beneficiaries and to assess the knowledge of drug distributors towards the filariasis and MDA programme. Methods: This cross sectional study was conducted in 3 rural and 1 urban clusters in Bidar district for the period of 1 week. 50 houses were selected in each cluster by systematic random sampling method and data was collected in a structured proforma by interview technique. Results: Majority of beneficiaries were at the age group of 15-60 years (72.3% and male (53%. The overall coverage of MDA in Bidar district was 62.3%. Compliance among those who had received the tablets was 60.4%. Coverage and compliance was more in rural areas compared to urban. The most common reason quoted for not consuming drugs was fear of adverse effects (72.2% The incidence of adverse events was 0.2%. Even though 75% of them were aware of the disease elephantiasis, only 45.4% had knowledge regarding MDA programme. The knowledge of drug distributors towards MDA and filariasis was found to be adequate. Conclusions: Coverage and compliance towards MDA in Bidar district was poor. The coverage and compliance in rural areas was higher compared to the urban areas.

  17. Hubungan Kondisi Lingkungan dengan Kasus Filariasis di Masyarakat (Analisis Lanjut Hasil Riskesdas 2007

    Directory of Open Access Journals (Sweden)

    Santoso Santoso

    2013-02-01

    Full Text Available Abstracts. Filariasis (elephantiasis disease in Indonesia is still a health problems, there are still areas with the patient chronic and acute. A total of 1553 villages in 647 health centers scattered in 231 districts in 26 provinces as the location of the endemic, with a number of chronic cases of 6233 people. Elimination program disease elephantiasis has been undertaken by the government, but until today there are still many areas with the number of microfilariae (Mf rate is still high (> 1%. One of the government's efforts in this regard Litbangkes RI in collecting basic data, including data filariasis is with the activities of the Basic Health Research (Riskesdas conducted simultaneously across Indonesia. Based on the results of data collection Riskesdas then further analysis is to look at the environmental conditions and demographic status associated with the incidence of filariasis. Based on the results of analysis show that there were a statistically significant relationship between the type of waste water reservoirs; types of sewage systems and types of livestock kept, the classification of villages with the incidence of filariasis.Keywords: riskesdas, filariasis, environmental, demographic status

  18. Perceptions, knowledge, attitudes and practices for the prevention and control of lymphatic filariasis in Conakry, Republic of Guinea.

    Science.gov (United States)

    Kouassi, Bernard L; Barry, Aboulaye; Heitz-Tokpa, Kathrin; Krauth, Stefanie J; Goépogui, Andre; Baldé, Mamadou S; Barry, Oumar; Niamey, Marie L; Bockarie, Moses J; Koudou, Benjamin G; Utzinger, Jürg

    2018-03-01

    Little is known about the perceptions, attitudes and practices of lymphatic filariasis in Conakry, Republic of Guinea. Yet, such knowledge is important for an optimal design and implementation of setting-specific prevention and control measures. We conducted a cross-sectional study using a mixed methods approach. Qualitative data related to people's general experience with lymphatic filariasis, their perception of the causes of the disease, the onset of elephantiasis, care-seeking behaviour and the socioeconomic impact of lymphatic filariasis were collected through in-depth interviews with 85 respondents. Quantitative data related to strategies for prevention and the knowledge of the causes of the disease were collected by interviewing 429 people. A total of 514 individuals (313 females and 201 males), aged 10-84 years, participated. Most participants were well aware of lymphatic filariasis and they recognized the disease mainly by its disfiguring manifestation, collectively termed "elephantiasis" or "leg-swelling disease". Morbidity patterns due to filarial infection showed an increase with age (from 30 to 50 years) independent of sex. Most patients with lymphatic filariasis abandoned their jobs (73.9%) or sought other work (21.7%). The main perceived causes of acquiring lymphatic filariasis were of supernatural origin (as stated by 8.7% of patients and 5.7% of healthy subjects), while mosquito bites were mentioned by fewer participants (4.3% of patients and 4.2% of healthy subjects). A number of other causes were reported that relate to both medical and non-medical conceptions. The study also identified socioeconomic impairments and stigmatization due to elephantiasis. Taken together, community perception of lymphatic filariasis in Conakry is influenced by sociocultural conceptions. Appropriate health education campaigns aimed at enhancing community understanding of the transmission of lymphatic filariasis are required to increase the success of mass drug

  19. Diversitat llingüística i educació

    Directory of Open Access Journals (Sweden)

    Inmaculada Mas Álvarez

    2011-12-01

    Full Text Available Presentem les activitats conjuntes dutes a terme al 2n curs de formació de mestres (Llengua estrangera per a les assignatures de Lingüística i Llengua espanyola a la Universitat de Santiago de Compostela. Des d'un context universitari d'adaptació a l'Espai Europeu d'Educació Superior i tenint en compte que ens trobem en una comunitat bilingüe, els objectius comuns principals de las nostras programaciós han estat: contrarestar l'excessiva fragmentació entre les matèries lingüístiques, promoure la reflexió sobre la presa de consciència de la diversitat lingüística i cultural, fomentar l'aplicació de les TIC i potenciar el treball col.laboratiu.

  20. Metodi matematici per la teoria dell’evoluzione

    CERN Document Server

    Bazzani, Armando; Freguglia, Paolo

    2011-01-01

    Esistono ormai da tempo molti articoli, in particolar modo su riviste di biomatematica, di (bio)fisica e di biologia, che presentano proposte e risultati di modellistica matematica relativi direttamente ed indirettamente alla teoria dell’evoluzione. Sicuramente questi studi sono da considerarsi cruciali per l’istituzione della biologia teorica. I temi da prendere in esame sono dapprima le convinzioni che i biologi hanno in merito. Quindi un’analisi dei precedenti tentativi di formulare una teoria matematica dell’evoluzione, nonché i relativi sviluppi e insuccessi a cui abbiamo assistito nell’ambito della "teoria della complessità". La nostra proposta consiste dunque nel realizzare una teoria matematicamente formulata e biologicamente ben fondata dell’evoluzione con specifico e giustificato riferimento a quella fenotipica. Quindi su questa base costruiamo sia di un modello geometrico sia un modello dinamico stocastico. In questo modo, pur tenendo presente l’intrinseca insufficienza dell’appro...

  1. Encontre Internacional Noves fronteres de la ciència, l'art i el pensament : física de l'estètica

    CERN Document Server

    Perello, Josep; Física de l'estètica : noves fronteres de la ciència, l'art i el pensament

    2006-01-01

    Recopilació dels textos de les reflexions que van tenir lloc en l'encontre internacional "Noves fronteres de la ciència, l'art i el pensament. Física de l'estètica", celebrat els dies 6 i 7 de setembre de 2005 a l'Auditori Caixa Catalunya-l a Pedrera de Barcelona. En la trobada es plantejaren preguntes universals relati ves als límits de la nostra percepció, al disseny de la matèria o a la narrativa de la complexitat circumdant. Va comptar amb la collaboración de personalitats d'àmbits no científics que, des de la seva perspectiva, contribuiren a destil·l ar l'estètica emanada de les tendències contemporànies d'aquesta disciplina cien tífica.

  2. Žarko Muljačić, Das dalmatische Studien zu einer untergegangenen Sprache, Quellen und Beiträge zur croatischen Kulturgeschichte, 10. Hg. Elisabeth von Erdmann-Pandžić, Böhlau Verlag, Köln Weimar Wien, 2000, pag. 434.

    Directory of Open Access Journals (Sweden)

    Mitja Skubic

    2003-12-01

    Full Text Available E' la questione, qui, di una romanita sommersa. Il volume degli scritti sul dalma­ tico di Zarko Muljacic, spalatino di nascita, grande ricercatore dell'antica romanita in Dalmazia, riunisce i suoi studi, concepiti e pubblicati nell'arco di quasi mezzo se­ colo, sulla sorte dell'antico romanzo sulle coste dalmate, scomparso, quanto al ragu­ seo, nel tardo Quattrocento e definitivamente, sull'isola di Veglia, alla fine dell'Otto­ cento con la morte dell'ultimo veklisun. Il fenomeno non  e della nostra epoce e per­cio lo prendiamo  come un dato di fatto, vale a dire senza provare  emozioni, mentre l'inarrestabile tramonto del giudeo-spagnolo in Bosnia o dell'istroromeno  in!stria al quale assistiamo attualmente ci colpisce di piu.

  3. Obtenir mostres de color i comparar-les

    Directory of Open Access Journals (Sweden)

    Ana Entenza Rodríguez

    2014-01-01

    Full Text Available La nostra intenció era investigar l'ús del color en una sèrie de peces comunicatives, però en descriure com seleccionaríem i classificaríem les mostres, vam veure que aquest pas inicial suposava un estudi en si mateix, perquè classificar una cosa que no està acotat en quantitat (algunes aplicacions treballen amb milions, que disposa de diferents nomenclatures (en funció de cultures i països, del qual amb prou feines coneixem una dotzena de noms i que varia en funció de les condicions de llum, de suport, o de qualitat de reproducció, requereix reflexió i aprofundiment.

  4. Caso e caos

    CERN Document Server

    Ruelle, David

    1992-01-01

    Caso e caos – Il caso ha la sua ragione. Ma quale? E cos’è in realtà il caso? Da dove viene e come può fare irruzione nella nostra descrizione dell’universo? A tutte queste domande, in una chiara e lucida esposizione, cerca di dare risposta David Ruelle. Curiosando tra i risultati scientifici del XX secolo e soffermandosi anche su fenomeni e problemi estranei alla scienza tradizionale – le lotterie, gli oroscopi, la teoria dei giochi, la genesi della turbolenza – Ruelle ci guida a conoscere il caso avendo la matematica, la fisica e tutte le scienze naturali come compagne. Ancora oggi il modo in cui il caso irrompe nelle nostre vite e nel mondo può essere un mistero, ma grazie ai progressi della scienza, qui raccontati, riusciamo a saperne un poco di più.

  5. De la "inutilitat" del passat a la "comoditat" del present. La rendibilitat de les ciències socials en el segle XXI

    Directory of Open Access Journals (Sweden)

    Joan Anton Barceló

    1999-11-01

    Full Text Available Per a la major part de la gent el mot "arqueològic" és sinònim de inútil, atès que es tracta de quelcom antic. Si et diuen que tens una manera de vestir "arqueològica", de fet t'insulten, perquè el que opinen és que no vas a la moda. Si un pensador o un llibre és titllat de "arqueològic", el que es vol dir és que de tan antic com és ha perdut actualitat i transcendència. El que és molt antic no serveix per a res, precisament per això, perquè és antic i és lluny de nosaltres. És una altra cosa, sense cap mena de relació amb la nostra experiència quotidiana.

  6. Note di fotonica

    CERN Document Server

    Degiorgio, Vittorio

    2016-01-01

    L’invenzione del laser ha generato una vera rivoluzione nella scienza e nella tecnologia e ha dato luogo alla nascita di una nuova disciplina chiamata Fotonica. Le applicazioni della Fotonica che hanno un impatto cruciale in molti ambiti della nostra vita sono le comunicazioni in fibra ottica su cui si basa il funzionamento di Internet e del traffico telefonico su grandi distanze, i dischi ottici (CD, DVD, Blu-ray), la sensoristica ottica di tipo industriale e ambientale, la lavorazione dei materiali e la chirurgia con il laser, l’illuminazione con i LED. Questa seconda edizione contiene diversi ampliamenti e modifiche al testo pubblicato nel 2012, che ha colmato un vuoto nel panorama italiano di testi universitari riguardanti la Fotonica. Dopo avere esposto in modo sintetico ma rigoroso i concetti che stanno alla base del funzionamento del laser e della propagazione della luce nella materia, sono descritti i principali componenti e dispositivi ottici e optoelettronici, quali le fibre ottiche, gli amplifi...

  7. L'adaptació familiar en l'adopció internacional

    OpenAIRE

    Ger Cabero, Sandra

    2016-01-01

    En els darrers anys l’adopció internacional s’ha convertit en una realitat molt estesa en el nostre país. D’ençà que va ratificar el Conveni de la Haia, Espanya s’ha convertit en un dels països on s’han realitzat més adopcions a l’estranger (des del 1997 més de 50.000 infants han estat adoptats internacionalment per famílies espanyoles). Això implica que el nombre d’infants adoptats internacionalment que creixen en la nostra societat és considerable, fet que fa necessari l’estudi de l’adaptac...

  8. Disseny didàctic amb ús intencionat de TIC per potenciar l'aprenentatge dels estudiants d'embriohistología

    OpenAIRE

    Reyes Hernández, Héctor Félix; González Wong, Yurnet

    2014-01-01

    Aquest article tracta de la implementació d’un disseny didàctic amb ús intencionat de TIC com a conseqüència de la importància que ha adquirit a l’actualitat, i en particular en el context de l’educació superior. La perspectiva és potenciar la docència i l’aprenentatge en estudiants universitaris, atès que la nostra experiència docent ens demostra que no sempre s’utilitza el recurs TIC en un disseny didàtic adequat. Aquest estudi va tenir com a objectiu avaluar l’efectivitat de l’aplicació a ...

  9. Implantació de la UNE-EN ISO 22716 en una planta d'envasats de cosmètics.

    OpenAIRE

    Cantarell Bernadó, Arnau

    2014-01-01

    Aquest projecte consisteix en la implementació de la Norma ISO 22716 de Bones Pràctiques Cosmètiques a la secció d’envasat de la nostra planta de producció. S’ha començat per fer una primera inspecció en cadascuna de les zones que interactuen en el procés d’envasat, i a partir d’aquí s’han fet una sèrie de propostes de millora segons el text original de la Norma. S’ha previst la implementació de totes les mesures correctores proposades, tant a nivell de procés com a nivell d...

  10. Ladinia linguistica in una monumentale opera: Atlante linguistico del ladino dolomitico e dei dialetti limitrofi - ALD-1, Dr. Ludwig Reichert Verlag, Wiesbaden 1998

    Directory of Open Access Journals (Sweden)

    Mitja Skubic

    2000-12-01

    Full Text Available L'apparizione dell'atlante linguistico di un territorio romanzo va salutata con gioia, come una festa della ricerca scientifica in tale settore. E il sentimenta di gioia ci pervade quando sfogliamo i primi quattro volumi, in folio, dell 'ALD. Non solo per la mole e l'ampia concezione dell'opera, ma altrettanto e più ancora per il ricco materiale che l' ALD offre. A tutta l' equipe scientifica guidata dal rinomato romanista salisburghese prof. Hans Goebl che assieme a Lois Craffonara é anche ideatore dell 'opera, nonché ai collaboratori e all'editore vadano i nostri sinceri ringraziamenti. Ci sia permesso di aggiungere che la nostra rivista si pregia d'aver potuto ospitare alcuni studi scientifici del prof. Goebl, come anche del suo stretto collaboratore prof. Roland Bauer.

  11. Skjern River Restoration Counterfactual

    DEFF Research Database (Denmark)

    Clemmensen, Thomas Juel

    2014-01-01

    In 2003 the Skjern River Restoration Project in Denmark was awarded the prestigious Europa Nostra Prize for ‘conserving the European cultural heritage’ (Danish Nature Agency 2005). In this case, however, it seems that the conservation of one cultural heritage came at the expense of another cultural...... this massive reconstruction work, which involved moving more than 2,7 million cubic meters of earth, cause a lot of ‘dissonance’ among the local population, the resulting ‘nature’ and its dynamic processes are also constantly compromising the preferred image of the restored landscape (Clemmensen 2014......). The presentation offers insight into an on-going research and development project - Skjern River Restoration Counterfactual, which question existing trends and logics within nature restoration. The project explores how the Skjern River Delta could have been ‘restored’ with a greater sensibility for its cultural...

  12. Le proposte di modifica dell'impugnazione del licenziamento:  un passo avanti e due indietro (art. 67 del d.d.l. 1441 quater ­ atti camera deputati

    Directory of Open Access Journals (Sweden)

    Calogero Massimo Cammalleri

    2010-12-01

    Full Text Available In questo articolo si studiano i probabili effetti che la proposta riforma delregime di impugnazione del licenziamento, ove approvata, determinerà sul sistema diprotezione contro i licenziamenti illegittimi, concludendo per la sua inefficacia e dan­nosità. Segue una nostra proposta per l'accelerazione del processo del lavoro in mate­ria di licenziamenti e il miglioramento del grado di certezza del giudizio.In this article we study the likely effects that the draft law of the reform ofdismissal, if approved, will determine on the system of protection against unfair dis­missal. In our opinion it is ineffectiveness and harmfulness. Following a proposal foraccelerating the trial about lawful dismissals and to improve the degree of certainty oflegal proceedings.

  13. Una nuova rubrica di Archeomatica

    Directory of Open Access Journals (Sweden)

    Renzo Carlucci

    2005-02-01

    Full Text Available La parte umanistica della nostra rivista è in espansione e da questo numero si parte con un'altra avventura che si accoda a quella già avviata l'anno scorso con Arte e Scienza. Archeologia, Informatica e Geomatica s'incontreranno su uno spazio loro dedicato, la rubrica di Archeomatica. Essa prende il via con un articolo sul Sistema Informativo Geografico della Valle del Colosseo, le cui varie cartografie, da quelle storiche fino alle più recenti, i disegni e i rilievi di scavo s'integrano in modelli numerici CAD, tridimensionali, riuniti da un'unica relazione spaziale che li colloca e li indicizza mettendoli a disposizione dell'utente.

  14. Ladinia linguistica in una monumentale opera: atlante lunguistico del ladino dolomitico e dei dialetti limitrofi - ald-1, Dr. Ludwig Reichert Verlag, Wiesbaden 1998.

    Directory of Open Access Journals (Sweden)

    Mitja Skubic

    2015-08-01

    Full Text Available L'apparizione dell'atlante linguistico di un territorio romanzo va salutata con gioia, come una festa della ricerca scientifica in tale settore. E il sentimento di gioia ci pervade quando sfogliamo i primi quattro vol umi, in folio, deli' ALD. Non sol oper la mole e l'ampia concezione dell'opera, ma altrettanto e più ancora per il ricco materiale che l 'ALD offre. A tutta l' équipe scientifica guidata dal rinomato romanista salisburghese prof. Hans Goebl che assieme a Lois Craffonara e anche ideatore deli' opera, nonché ai collaboratori è all'editore vadano i nostri sinceri ringraziamenti. Ci sia permesso di aggiungere che la nostra rivista si pregia d'aver potuto ospitare alcuni studi scientifici del prof. Goebl, come anche del suo stretto collaboratore prof. Roland Bauer.

  15. Oltre lo spazio e il tempo la nuova fisica

    CERN Document Server

    Lachièze-Rey, Marc

    2004-01-01

    Oggi la fisica si fonda, allo stesso tempo, sulla meccanica quantistica e sulla relatività generale. Ma, in quanto veri e propri sistemi di pensiero, queste due teorie suggeriscono due distinte visioni del mondo, non conciliabili nel quadro di una descrizione unificata. Se dunque la fisica attuale si rivela inadeguata, occorre costruirne una nuova, percorrendo fino in fondo la via geometrica. Supersimmetria, stringhe e superstringhe, gravità e cosmologia quantistiche, geometria non commutativa: nuove audaci ipotesi al servizio di nuove teorie che rinnovano la nostra concezione dello spazio, del tempo, della materia e dell'Universo, e che trovano nel volume una presentazione chiara e accessibile anche a un pubblico di non specialisti.

  16. Gli incerti confini del cosmo dai buchi neri alle macchine del tempo

    CERN Document Server

    De Felice, Fernando

    2000-01-01

    Il libro mostra come la gravitazione abbia un ruolo determinante nei fenomeni cosmici che più ci impressionano, da quelli relativamente vicini alla nostra esperienza (come la formazione delle stelle) a quelli meno intuibili (come la formazione dei buchi neri), alla struttura dell'Universo nel suo insieme. Oltre a spiegare, in modo qualitativo, concetti come la geometria dello spazio-tempo, la relatività del tempo e i coni di luce, l'autore formula un'ipotesi innovativa tendente a spiegare l'origine della gravitazione e con essa quella dei fenomeni circondati ancora da un alone di mistero: la materia oscura dell'Universo e il destino della materia alla fine del collasso gravitazionale.

  17. Il Discorso o Dialogo di Machiavelli: Per l’“Evento” del Materialismo

    Directory of Open Access Journals (Sweden)

    Yuri Brunello

    2014-12-01

    Full Text Available L’autenticità del Discorso o dialogo intorno alla nostra lingua è stata più volte messa in discussione. A tutti gli effetti, l’immagine di Machiavelli che affiora dal Discorso o dialogo rientra in una discorsività incompatibile con il cinismo assolutista o con l’utopismo patriottico e populista associato per secoli al nome di Machiavelli. L’emergere del materialismo del Discorso o dialogo, come anche del Principe, è stato il più delle volte rimosso da un’esegesi interessata a reprimerne il messaggio sovversivo. Richiamando Spinoza, Gramsci e Badiou, il presente lavoro si propone di analizzare il materialismo di Machiavelli e la sua portata rivoluzionaria

  18. Victimització sexual a Catalunya segons el gènere i l'edat de la víctima

    OpenAIRE

    Hernández Soriano, Maria Gemma

    2017-01-01

    Durant els últims anys, el nombre de delictes sexuals ha anat incrementant, la qual cosa provoca una gran preocupació dins la nostra societat. La discrepància en la recollida de dades oficials al respecte i la falta d'enquestes de victimització fan molt complicada l'anàlisi de la prevalença de la victimització sexual. El present estudi s'ha realitzat en l'àmbit geogràfic de Catalunya. Els objectius són definir el perfil de la víctima segons les seves característiques individuals - gènere i ed...

  19. Pasolini i Haneke contra una estètica de l’Horror

    OpenAIRE

    Torres Roselló, Jordi

    2013-01-01

    Dir que la violència és el problema fonamental d’Europa i del món és només constatar un fet. El cinema contemporani europeu reflecteix aquesta preocupació en cada fotograma de metratge que surt del continent i que, com la pell del nostre poble, ens recorda el nostre passat, ens presenta la conjuntura actual, i ens descriu un futur inquietant. Però l’essencial, avui en dia, no és comprovar l’indiscutible pes de la temàtica violenta en la nostra realitat factual i cinematogràfica –fet que deixa...

  20. Intervenciones en la Aljafería de Zaragoza

    Directory of Open Access Journals (Sweden)

    Ángel Luis Franco Lahoz

    2001-12-01

    Full Text Available The installation of the Cortes de Aragón in Aljafería Palace culminated a long historic process that made this monumental complex, a mixture of art styles and cultures, into a symbol of Aragón’s identity. The first stage of restoration works that began in 1985 was followed by another more recent intervention, which has been awarded the 2001 Europa Nostra Diploma for restoration. The architects Luis Franco and Mariano Pemán sum up the process below, which they based on a pondered reflection about Íñiguez’s earlier intervention in an attempt to find an answer to the many doubts that came up regarding the refurbishment of the palace.

  1. Jeanne Hersch: una filosofia dei contorni

    Directory of Open Access Journals (Sweden)

    Roberta De Monticelli

    2013-07-01

    Full Text Available A Si tracciano le linee fondamentali del pensiero di Jeanne Hersch (Ginevra, 1910-2000, che concepisce la filosofia come servizio anti-idolatrico nei confronti della trascendenza da un lato, e dall’altro come continua presa di coscienza dei gesti della libertà che fanno irriducibile al dato e insieme profondamente individuata, qui ed ora, la nostra vita. Si mostra come l’ontologia di questa pensatrice sia indissociabile dalla sua estetica, o piuttosto dalla sua teoria del fare umano quale partecipazione finita e incarnata alla creazione. Si mostra il nesso da lei particolarmente sottolineato fra consistenza morale personale e responsabilità del pensiero teorico, sulla base dell’esempio negativo di Heidegger, sostenitore del nazismo. Si discute la netta presa di posizione che Jeanne Hersch assume contro le seduzioni e le liturgie verbali del suo pensiero incantatorio, irresponsabile nei confronti della verità e “radicato nel disprezzo”.

  2. I sei numeri dell'universo le forze profonde che spiegano il cosmo

    CERN Document Server

    Rees, Martin

    2002-01-01

    È possibile che sei semplici numeri, sei costanti universali, diano conto dell'infinita varietà e della stupefacente complessità del cosmo? L'astrofisico Martin Rees ci mostra che non soltano ciò è possibile, ma in quei sei numeri sono scritti la storia, la struttura e il futuro dell'universo, e che perfino la comparsa della vita sulla terra, e dunque la nostra stessa esistenza, non sarebbe concepibile se uno solo di quei valori numerici, definiti nell'istante che segnò la nascita del mondo, fosse differente. I sei numeri dell'universo ci introducono così ad alcune delle questioni più profonde su cui si interroga oggi la scienza.

  3. Sobre el Pensament Primordial i la seva Pedagogia

    Directory of Open Access Journals (Sweden)

    Hector Salinas

    2014-01-01

    Full Text Available Aquest article tracta de cridar l'atenció sobre les maneres originals de pensar, originals en el sentit que són autobiogràfiques i sempre es mantenen en l'els re-inicis del pensar; doncs cada vegada que elevem una teoria o un simple punt de vista, estem, en realitat, re-presentant, tornant a presentar els punts de vista que recollim. La qual cosa només és possible des de la nostra localització real i històrica. Tot és en realitat un re-construcció. El mateix succeeix amb els intents de renovació educativa, precisen una espècie de “salt enrere”, un re-començo.

  4. Heaney l’amante infelice. Riprese del libro VI dell’Eneide

    Directory of Open Access Journals (Sweden)

    Alberto Fraccacreta

    2015-11-01

    Full Text Available Seamus Heaney è forse l’amante infelice del Cristianesimo. Il rispetto per i morti, per le lacerazioni e infezioni nazionali – rispetto cantato superbamente in Station Island – spinse il poeta irlandese a cercare il rimedio alla crisi dei valori in un sistema trascendenteanteriore a quello intimamente cristiano: i Campi Elisi virgiliani. «Una fede lieve e pesante come la mannaia di una ghigliottina», suggerisce inconsapevolmente Kafka. Con Virgilio Heaney condivideva anche la sorte di esule. Nella nostra epoca assetata di alterità politica e metafisica, il loro rapporto va più a fondo della semplice ‘ripresa’, ‘traduzione’, ‘rilettura’: in entrambi si scorge l’inconfondibile tensione verso l’assolutamente altro, la trascendenza che, rinnovata, torna a investire il reale della sua potenza. Heaney e Virgilio, in una voce unica e stentorea,  divengono per la nostra epoca quasi un destino irrinunciabile. With respect to Christianity, Seamus Heaney may be considered an ‘unsatisfied lover’. His reverence towards both the dead and the wounds of his nation – a reverence majestically sung in Station Island – set the Irish poet on search for a remedy to the crisis of Christian values. That search found its fullfillment in a transcendence system prior to the Christian one: Virgil’s Elysium. «A belief is like a guillotine, just as heavy, just as light.», Kafka unsconsciously suggests. Heaney and Virgil even shared the same outcast fate. In our age – which craves for political and metaphysical otherness – the link between Heaney and Virgil is way deeper than mere reinterpretation or reworking. In both of them, we can glimpse the unique tension towards the Absolute Other – that is transcendence – which comes back to fill reality with its renewed power. Heaney and Virgil are one single stentorian voice, and they represent an undeniable destiny from the point ofview of our times.

  5. Tecnoperceptives de la sonoritat electrònica en la cibercultura

    Directory of Open Access Journals (Sweden)

    Begoña Abad Miguélez

    2003-11-01

    Full Text Available Les noves tecnologies de la comunicació i de la informació es caracteritzen per fer possible nous usos tècnics, des dels punt de vista instrumental, i noves pràctiques tecnològiques que remeten a relacions intersubjectives, comportaments, representacions... La cultura de l'ordinador, la cibercultura, no n'és cap excepció. Amb la generalització i l'afinament del dispositiu original que la crea, es generen socialment les condicions per a un canvi radical de les pràctiques, dels conceptes i dels punts de suport culturals més estables. La major part dels autors que s'han ocupat d'aquest canvi del sensorium cultural han tendit a centrar-se en la velocitat i acceleració de les imatges i dels textos deixant de costat el paper que realitza el so i el silenci. Deixant de banda, en definitiva, el paper de la música generada electrònicament. Amb tot, en una època "digital" on els ordinadors governen la nostra vida quotidiana, seria imperdonable que no penséssim en la música electrònica, digitalitzada, com a banda sonora més adient per a aquest nou context. És per això que en aquest treball volem prendre en consideració alguns dels canvis culturals que caracteritzen la cibercultura, i mirar d'establir connexions entre la revolució de les imatges i la revolució de la musicalitat, tant les unes com l'altra generades electrònicament. L'objectiu últim de la nostra incursió en aquest camp és apropar-nos als efectes de sentit de les tecnoperceptives de la sonoritat electrònica en la que podem anomenar "era de les màquines intel·ligents".

  6. Seasonal changes of peroxidase and catalase activities in leaves of several arborescent species subject to different industrial air pollutions in Upper Silesia

    Energy Technology Data Exchange (ETDEWEB)

    Raczek, E.; Stolarek, J.

    1979-01-01

    Year-round investigations of seasonal patterns of peroxidase and catalase activities in leaves of several deciduous and coniferous arborescent species in forests of Upper Silesia subjected to various amounts of industrial gases and dusts were carried out. The samples of leaves of Betula verrucosa EHRH, Quercus robur L., Q. rubra L., Pinus nigra ARNOLD, and P. silvestris L. were collected at different distances from an iron smelting plant. It was found that raising level of the pollution enhances peroxidase activity in leaves and needles. The induction of peroxidase activity by pollutants exhibited seasonal changes specific for the species and was subjected to the effect of temperature of the environment and was also related to the natural resistivity of a given species. In contrast to peroxidase, the patterns of catalase activity changes did not appear to be specifically influenced by industrial air pollutants. 22 references, 5 figures, 4 tables.

  7. Coral microbial community dynamics in response to anthropogenic impacts near a major city in the central Red Sea

    KAUST Repository

    Ziegler, Maren; Roik, Anna Krystyna; Porter, Adam; Zubier, Khalid; Mudarris, Mohammed S.; Ormond, Rupert; Voolstra, Christian R.

    2016-01-01

    Coral-associated bacteria play an increasingly recognized part in coral health. We investigated the effect of local anthropogenic impacts on coral microbial communities on reefs near Jeddah, the largest city on the Saudi Arabian coast of the central Red Sea. We analyzed the bacterial community structure of water and corals (Pocillopora verrucosa and Acropora hemprichii) at sites that were relatively unimpacted, exposed to sedimentation & local sewage, or in the discharge area of municipal wastewaters. Coral microbial communities were significantly different at impacted sites: in both corals the main symbiotic taxon decreased in abundance. In contrast, opportunistic bacterial families, such as e.g. Vibrionaceae and Rhodobacteraceae, were more abundant in corals at impacted sites. In conclusion, microbial community response revealed a measurable footprint of anthropogenic impacts to coral ecosystems close to Jeddah, even though the corals appeared visually healthy.

  8. Preliminary results on Macroalgae distribution in destructive processes

    Directory of Open Access Journals (Sweden)

    O.I. OSKOLSKAYA

    2001-06-01

    Full Text Available It has been shown, that the destruction of the coastal strip in region of action of Mikhailovsky landslide results in change of species structure and dominant species photophilous Cystoseira barbara on sciophylous Gracilaria verrucosa. In accordance with increasing sediments amount in sea water biomass and the morpho-functional parameters of the photophilous species are reducing, and at the sciophylous are growing. Progressing phenomenon of epiphytism is observed in algal populations in the southern part of researched region which is possible to consider as response reaction, leads to increase a synthesizing surface. Decreasing physiological activity is compensated by growth of the total surface of macrophytes. The increase of a sea water sediments leads to lowering ratio of long and shortwave pigments level of ATP-ase activity and raising concentration of the total sum of pigments in thalli.

  9. The blocking activity of birch pollen-specific immunotherapy-induced IgG4 is not qualitatively superior to that of other IgG subclasses

    DEFF Research Database (Denmark)

    Ejrnaes, Anne M; Bødtger, Uffe; Larsen, Jørgen N

    2004-01-01

    IgE were detected using 125I-labelled rBet v 1.2801, a recombinant variant of the major allergen of Betula verrucosa pollen. Results show that IgG4-depletion resulted in equivalent reductions in binding and blocking activities. In contrast, a significant but less than two-fold higher relative...... for the clinical efficacy of SIT. In this study, fractionated serum samples from 14 SIT-treated birch pollen allergic individuals enabled determination of the inhibitory capacity of IgG4 alone versus non-IgG4 IgG. Allergen-binding activities of IgG and the IgG-mediated inhibition of allergen binding to autologous...

  10. Aspects of petroleum hydrocarbon metabolism in marine animals

    Science.gov (United States)

    Mironov, O. G.

    1980-03-01

    Studies on hydrocarbon composition of Black Sea mussels Mytilus galloprovincialis sampled from different habitats indicate that the quantity and composition of hydrocarbons distributed in the molluscs depend on season and sea-water quality. The data obtained under experimental conditions testify to the possibility of hydrocarbon concentration in mussel tissues after death. During filtration in sea water containing oil and oil products, these pollutants are bound into faeces and pseudofaeces which contain a greater percentage of aromatic compounds than the oil initially present in sea water. Quantitative data are presented on hydrocarbon changes in mussel excretory products during transfer from oil-polluted to clean sea water. When Black Sea crabs Eriphia verrucosa are fed with mussels containing fuel-oil components accumulated from sea water, the pollutants concentrate in the whole body of the crab. This is in contrast to parenteral oil uptake, which leads to a concentration of most of the hydrocarbon in the muscles.

  11. Influence of fumes from industrial works on the seasonal development of trees and shrubs

    Energy Technology Data Exchange (ETDEWEB)

    Antipov, V G

    1957-01-01

    Phenological observations were made at Leningrad in 1953 and 1954 on woody species growing near three chemical works. Controls were observed in an unpolluted park. Data on the relative incidence of the main phenological phases (flushing, flowering, fruiting, autumn coloration and leaf-fall) are tabulated separately for each works. Pollution curtailed the growing season to some degree in all species; its effect in hastening coloration and leaf-fall was more marked than in retarding the spring phases. The least susceptible species were Populus balsamifera, P. suaveolens, Alnus incana, Quercus robur, Fraxinus excelsior, Amelanchier rotundifolia and Lonicera tatarica. Species unsuited for cultivation in these conditions are Caragana arborescens, Prunus padus, Tilia cordata, Ulmus laevis, Crataegus oxyacantha, Betula pubescens and B. verrucosa.

  12. La fauna de caprélidos (Crustacea: Amphipoda: Caprellidea de la costa de Coquimbo, centro-norte de Chile, con una clave taxonómica para la identificación de las especies The caprellid fauna (Crustacea: Amphipoda: Caprellidea from the coast of Coquimbo, Northern-central Chile, with a taxonomic key for species identification

    Directory of Open Access Journals (Sweden)

    JOSÉ M. GUERRA-GARCÍA

    2001-12-01

    Full Text Available Los caprélidos son comunes y abundantes en muchos hábitats litorales del ambiente marino. Sin embargo este grupo de anfípodos no ha sido muy bien estudiado en la costa chilena. El estudio de los caprélidos se ha visto dificultado por su gran variabilidad morfológica y el hecho de que la literatura así como los especímenes de los museos son difíciles de localizar. El objetivo de este estudio fue entregar las herramientas taxonómicas para la identificación de las especies de crustáceos caprélidos comunes en el centro-norte de la costa de Chile. Se muestrearon distintos hábitats (boyas, bolones intermareales, praderas de algas y fanerógamas marinas y se encontraron seis especies distintas de caprélidos: Caprellina longicollis (Nicolet, 1849, Caprella equilibra Say, 1818, C. scaura Templeton, 1836, C. verrucosa Boeck, 1871; Deutella venenosa Mayer, 1890 y Paracaprella pusilla Mayer, 1890. Caprella scaura, C. verrucosa y D. venenosa fueron muy abundantes sobre las algas, hidrozoos y briozoos asociados a boyas. Caprella equilibra, también presente en boyas, fue más abundante bajo piedras en zonas intermareales rocosas expuestas, donde también se encontraron ejemplares de D. venenosa y de P. pusilla. Caprella scaura también se encontró sobre algas rojas de las playas arenosas, especialmente sobre Gracilaria chilensis y sobre la fanerógama marina Heterozostera tasmanica, donde cohabitó junto a Caprellina longicollis. Paracaprella pusilla constituye una nueva cita para las costas pacíficas sudamericanas, siendo nueva para la fauna de Chile. La especie D. venenosa, que se cita por primera vez después de la descripción original de Mayer en el año 1890, es considerada una especie endémica de la costa central de ChileCaprellids are abundant in many littoral habitats of the marine environment. Nevertheless, this group of amphipods has been scarcely studied along the coast of Chile. The study of the Caprellidea is particularly

  13. Impact of anthropogenic forest contamination on radioresistance of woody plant seed

    International Nuclear Information System (INIS)

    Yushkov, P.I.

    2004-01-01

    Radioresistance of seeds of bay willow (Salix pentandra L.) and great sallow willow (Salix caprea L.) from forests chronically affected and non-affected by acidic (SO 2 , NO x , HF, etc.) industries has been studied and compared. Bay willow seeds of 6 harvests showed no difference in radioresistance. However, seeds of both species manifested strong synchronous variability in resistance to preplant exposure. Also, no influence was observed of mother plant gas content on great sallow willow seeds of different harvests. Data obtained confirm similar results of previous studies conducted by the author (1987) to identify the impact of plant gas content on radioresistance of seeds and seedlings of pine (Pinus sylvestris L.) and birch (Betula verrucosa Erh.). (author)

  14. Coral microbial community dynamics in response to anthropogenic impacts near a major city in the central Red Sea

    KAUST Repository

    Ziegler, Maren

    2016-01-04

    Coral-associated bacteria play an increasingly recognized part in coral health. We investigated the effect of local anthropogenic impacts on coral microbial communities on reefs near Jeddah, the largest city on the Saudi Arabian coast of the central Red Sea. We analyzed the bacterial community structure of water and corals (Pocillopora verrucosa and Acropora hemprichii) at sites that were relatively unimpacted, exposed to sedimentation & local sewage, or in the discharge area of municipal wastewaters. Coral microbial communities were significantly different at impacted sites: in both corals the main symbiotic taxon decreased in abundance. In contrast, opportunistic bacterial families, such as e.g. Vibrionaceae and Rhodobacteraceae, were more abundant in corals at impacted sites. In conclusion, microbial community response revealed a measurable footprint of anthropogenic impacts to coral ecosystems close to Jeddah, even though the corals appeared visually healthy.

  15. When shape matters: strategies of different Antarctic ascidians morphotypes to deal with sedimentation.

    Science.gov (United States)

    Torre, Luciana; Abele, Doris; Lagger, Cristian; Momo, Fernando; Sahade, Ricardo

    2014-08-01

    Climate change leads to increased melting of tidewater glaciers in the Western Antarctic Peninsula region and sediment bearing glacial melt waters negatively affects filter feeding species as solitary ascidians. In previous work the erect-forms Molgula pedunculata and Cnemidocarpa verrucosa (Order Stolidobranchiata) appeared more sensitive than the flat form Ascidia challengeri (Order Phlebobranchiata). Sedimentation exposure is expected to induce up-regulation of anaerobic metabolism by obstructing the organs of gas exchange (environmental hypoxia) or causes enhanced squirting activity (functional hypoxia). In this study we evaluated the possible relationship between ascidian morphotype and their physiological response to sedimentation. Together with some behavioural observations, we analysed the response of anaerobic metabolic parameters (lactate formation and glycogen consumption) in different tissues of three Antarctic ascidians, exposed to high sediment concentrations (200 mgL(-1)). The results were compared to experimental hypoxia (10% pO2) and exercise (induced muscular contraction) effects, in order to discriminate the effect of sediment on each species and morpho-type (erect vs. flat forms). Our results suggest that the styled (erect) C. verrucosa increases muscular squirting activity in order to expulse excessive material, while the flat-form A. challengeri reacts more passively by down-regulating its aerobic metabolism under sediment exposure. Contrary, the erect ascidian M. pedunculata did not show any measurable response to the treatments, indicating that filtration and ingestion activities were not reduced or altered even under high sedimentation (low energetic material) which could be disadvantageous on the long-term and could explain why M. pedunculata densities decline in the study area. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Metabolite Profiling of Red Sea Corals

    KAUST Repository

    Ortega, Jovhana Alejandra

    2016-12-01

    Looking at the metabolite profile of an organism provides insights into the metabolomic state of a cell and hence also into pathways employed. Little is known about the metabolites produced by corals and their algal symbionts. In particular, corals from the central Red Sea are understudied, but interesting study objects, as they live in one of the warmest and most saline environments and can provide clues as to the adjustment of corals to environmental change. In this study, we applied gas chromatography – mass spectrometry (GC–MS) metabolite profiling to analyze the metabolic profile of four coral species and their associated symbionts: Fungia granulosa, Acropora hemprichii, Porites lutea, and Pocillopora verrucosa. We identified and quantified 102 compounds among primary and secondary metabolites across all samples. F. granulosa and its symbiont showed a total of 59 metabolites which were similar to the 51 displayed by P. verrucosa. P. lutea and A. hemprichii both harbored 40 compounds in conjunction with their respective isolated algae. Comparing across species, 28 metabolites were exclusively present in algae, while 38 were exclusive to corals. A principal component and cluster analyses revealed that metabolite profiles clustered between corals and algae, but each species harbored a distinct catalog of metabolites. The major classes of compounds were carbohydrates and amino acids. Taken together, this study provides a first description of metabolites of Red Sea corals and their associated symbionts. As expected, the metabolites of coral hosts differ from their algal symbionts, but each host and algal species harbor a unique set of metabolites. This corroborates that host-symbiont species pairs display a fine-tuned complementary metabolism that provide insights into the specific nature of the symbiosis. Our analysis also revealed aquatic pollutants, which suggests that metabolite profiling might be used for monitoring pollution levels and assessing

  17. Tipos polínicos encontrados em amostras de méis de Apis mellifera em Picos, Estado do Piauí Pollinic types found in honey samples of Apis mellifera from Picos, State of Piaui

    Directory of Open Access Journals (Sweden)

    Geni da Silva Sodré

    2008-06-01

    Full Text Available Com o objetivo de determinar os tipos polínicos de méis produzidos por Apis mellifera L., 1758, no município de Picos, Estado do Piauí, foram realizadas análises polínicas de 35 amostras de méis coletadas entre novembro e dezembro de 2001 no Laboratório de Apicultura do Departamento de Entomologia, Fitopatologia e Zoologia Agrícola da Escola Superior de Agricultura "Luiz de Queiroz", Universidade de São Paulo. A identificação dos tipos polínicos foi realizada por meio de descrições obtidas em literatura especializada. Os resultados demonstraram que foram encontrados 36 tipos polínicos, distribuídos em 18 famílias botânicas, sendo consideradas como pólen dominante Piptadenia sp. (Mimosaceae, Mimosa caesalpiniiaefolia Benth. (Mimosaceae, M. verrucosa Benth. (Mimosaceae e Croton urucurana Baill. (Euphorbiaceae.This research deals with the pollinic types of honeys produced by Apis mellifera L., 1758 in the municipality of Picos, State of Piaui were determined in the Laboratory of Apiculture, Department of Entomology, Phytopathology and Agricultural Zoology, College of Agriculture ‘Luiz de Queiroz', University of São Paulo, in Piracicaba, State of São Paulo, pollinic analysis of 36 honey samples collected in November and December of 2001. The identification of e pthollinic made by types was specialized literature. The results showed that 36 types of pollen were found, distributed in 18 botanical families, and the following plant species were considered as dominant Piptadenia sp. (Mimosaceae, Mimosa caesalpiniiaefolia Benth. (Mimosaceae, M. verrucosa Benth. (Mimosaceae and Croton urucurana Baill. (Euphorbiaceae.

  18. Novos registros do gênero Trachelomonas Ehr. (Euglenophyceae no Parque Estadual Delta do Jacuí e no Rio Grande do Sul, Brasil New records for the genus Trachelomonas Ehr. (Euglenophyceae in Jacuí Delta State Park, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Sandra Maria Alves-da-Silva

    2007-06-01

    Full Text Available O levantamento do gênero Trachelomonas Ehr. (Euglenophyceae em 26 corpos d´água da área do Parque Estadual Delta do Jacuí, localizado a 29º 56' e 30º 03'S, 5lº l2' e 51º 25'W, resultou no registro de nove novas citações de espécies de Trachelomonas Ehr. para o Estado do Rio Grande do Sul, são elas: Trachelomonas abrupta Swir. emend. Defl. var. obesa (Playf. Defl. T. conica Playf., Trachelomonas duquei Conf. & Nudelman, Trachelomonas megalacantha Cunha var. crenulatocollis Bour. & Manguin, Trachelomonas verrucosa Stockes var. granulosa (Playf. Hub.-Pest., Trachelomonas zingeri Roll, três são ainda novos registros para o país: Trachelomonas cylindraceae f. cylindraceae (Playf. Pop., Trachelomonas helvetica Lemm. emend. Defl. e Trachelomonas splendidissima Middelhoek. São apresentadas descrições, ilustrações, comentários, distribuição geográfica e a amplitude de condições ambientais em que cada táxon foi encontrado.A study of the genus Trachelomonas Ehr. (Euglenophyceae in 26 water bodies at Jacuí Delta State Park near the state capital of Rio Grande do Sul (29º56', 30º03'S; 51º12', 51º18'W revealed nine new records of Trachelomonas species for this state, as follows: Trachelomonas abrupta Swir. emend. Defl. var. obesa (Playf. Defl., T. conica Playf., Trachelomonas duquei Conf. & Nudelman, Trachelomonas megalacantha Cunha var. crenulatocollis Bour. & Manguin, Trachelomonas verrucosa Stockes var. granulosa (Playf. Hub.-Pest., Trachelomonas zingeri Roll; three are new records for Brazil: Trachelomonas cylindraceae f. cylindraceae (Playf. Pop., Trachelomonas helvetica Lemm. emend. Defl. and Trachelomonas splendidissima Middelhoek. Descriptions, illustrations, comments, geographic distribution and the range of environmental conditions in which each taxon was found are presented.

  19. BILATERAL CYSTIC SWELLING OVER SCAPULA-An Unusual Presentation of Filariasis

    Directory of Open Access Journals (Sweden)

    Deepak Kumar

    2018-05-01

    Full Text Available Lymphatic filariasis is a parasitic infection commonly known as elephantiasis. Filariasis presents as hydrocele, genital/scrotal swelling, adenolymphangitis (ADL, swelling of limbs, and genitalia. The causative agent resides in lymphatic channels and causes its obstructions leading to lymphedema. In India, males commonly present with hydrocele and females with lymphedema. Filariasis presenting as bilateral cystic swelling over the scapula is very rare even in endemic areas like India. Wuchereria bancrofti is the common causative agent of filarial infections in India. Here, we present a rare case of filariasis presenting as bilateral cystic swelling over the scapula. The imaging findings are discussed in the case report, which leads us to the diagnosis with further confirmation on microscopy by the presence of microfilariae within the cyst.No such case has been reported in the literature.

  20. A Clinico- Epidemiological Study Of Filarial Related Orthopaedic Manifestations

    Directory of Open Access Journals (Sweden)

    Patond K.R

    1992-01-01

    Full Text Available An epidemiological study was undertaken to study the incidence and distribution of orthopaedic manifestations of filariasis in an endemic area. A total of 207 cases were clinically examined and investigated. Patients were divided into three groups , viz., Group A: Orthopaedic manifestations with no history of filariasis . Group B: Orthopaedic manifestations with history of filariasis such as microfilaraemia or filarial fevers etc., Group C: Orthopaedic manifestations with chronic manifestations such as elephantiasis, hydrocele etc. To confirm filarial etiology, all the cases were examined for the presence of filarial antibody by indirect ELISA using wuchereda bancrofti microfilarial excretory- secretary antigen (wd Mf ESAg . A total of 61 of 102 patients of Group A, 14 of 21 patients of group B, and 73 of 84 patients of Group C were positive for filarial antibody. This study showed the prevalence of filarial antibody in about 71.4% of various orthopaedic manifestations.

  1. Idiopathic Gingival Fibromatosis Rehabilitation: A Case Report with Two-Year Followup

    Directory of Open Access Journals (Sweden)

    Mahesh Jayachandran

    2013-01-01

    Full Text Available Gingival enlargements are quite common and may be either inflammatory, noninflammatory, or a combination of both. Gingival hyperplasia is a bizarre condition causing esthetic, functional, psychological, and masticatory disturbances of the oral cavity. Causes of gingival enlargement can be due to plaque accumulation, due to poor oral hygiene, inadequate nutrition, or systemic hormonal stimulation (Bakaeen and Scully, 1998. It can occur as an isolated disease or as part of a syndrome or chromosomal abnormality. A progressive fibrous enlargement of the gingiva is a facet of idiopathic fibrous hyperplasia of the gingiva (Carranza and Hogan, 2002; Gorlin et al., 1976. It is described variously as fibromatosis gingivae, gingivostomatitis, hereditary gingival fibromatosis, idiopathic fibromatosis, familial elephantiasis, and diffuse fibroma. We present a case of idiopathic gingival fibromatosis with its multidisciplinary approach of management.

  2. Varicose vein disease in children with klippel-trenaunay syndrome

    Directory of Open Access Journals (Sweden)

    Yu.O. Syniachenko

    2017-02-01

    Full Text Available The article presents a review of the literature, which describes the clinical picture and diagnosis of varicose vein disease in Klippel-Trenaunay syndrome, methods of treatment with intravenous and transcutaneous laser coagulation, endovenous radioablation, foam sclerotherapy of vessels and venectomy. There are underlined genetic defects in the genesis of the disease, the role of pro-inflammatory and immunoregulatory imbalance of cytokines, growth factors, cell adhesion molecules, matrix metalloproteinases etс. in pathogenic constructions of venous damage. This congenital vascular patho­logy is not as rare as it is commonly thought, and the patients suffering from this pathology since childhood are often being unsuccessfully treated in adulthood for varicose veins, elephantiasis and recurrent phlebothrombosis, when diagnosis of Klippel-Trenaunay syndrome have never previously established. This literature review has to attract the attention to the problem under discussion not only of pediatricians, but also of therapeutists and vascular surgeons-phlebologists.

  3. Impact of community-based lymphedema management on perceived disability among patients with lymphatic filariasis in Orissa State, India.

    Directory of Open Access Journals (Sweden)

    Philip J Budge

    Full Text Available Lymphatic filariasis (LF infects approximately 120 million people worldwide. As many as 40 million have symptoms of LF disease, including lymphedema, elephantiasis, and hydrocele. India constitutes approximately 45% of the world's burden of LF. The Indian NGO Church's Auxiliary for Social Action (CASA has been conducting a community-based lymphedema management program in Orissa State since 2007 that aims to reduce the morbidity associated with lymphedema and elephantiasis. The objective of this analysis is to evaluate the effects of this program on lymphedema patients' perceived disability.For this prospective cohort study, 370 patients ≥14 years of age, who reported lymphedema lasting more than three months in one or both legs, were recruited from villages in the Bolagarh sub-district, Khurda District, Orissa, India. The World Health Organization Disability Assessment Schedule II was administered to participants at baseline (July, 2009, and then at regular intervals through 24 months (July, 2011, to assess patients' perceived disability. Disability scores decreased significantly (p<0.0001 from baseline to 24 months. Multivariable analysis using mixed effects modeling found that employment and time in the program were significantly associated with lower disability scores after two years of program involvement. Older age, female gender, the presence of other chronic health conditions, moderate (Stage 3 or advanced (Stage 4-7 lymphedema, reporting an adenolymphangitis (ADL episode during the previous 30 days, and the presence of inter-digital lesions were associated with higher disability scores. Patients with moderate or advanced lymphedema experienced greater improvements in perceived disability over time. Patients participating in the program for at least 12 months also reported losing 2.5 fewer work days per month (p<0.001 due to their lymphedema, compared to baseline.These results indicate that community-based lymphedema management programs

  4. Prevalensi Mikrofilaria setelah Pengobatan Masal 4 Tahun di Wilayah Kampung Sawah, Kecamatan Ciputat, Tangerang Selatan

    Directory of Open Access Journals (Sweden)

    Silvia F. Nasution

    2016-03-01

    Full Text Available Limphatic filariasis is a target of global diseases elimination promoted by WHO to accomplish by the year of 2020.Until 2008, 316 out of 471 districts/provinces were mapped epidemiologically as endemic areas of filariasis. South Tangerang is one of the district reported as an endemic area of filariasis, with Mf  prevalence ranged 1 – 2.4% determined from 2002 to 2009. Some factors play important roles in elimination program of filariasis, such as an appropriate diagnostic and its evaluation, and also annual program of Mass Drug Administration (MDA. In Ciputat area, South Tangerang district, the MDA has been conducted annually since 2009, and evaluation program by finger blood sample was also conducted in 2002 and 2009. Finding result showed prevalence 1.6% of Mf and 8 individu were clinically diagnosed as elephantiasis. Although the MDA has been conducted every year, but the evaluation has not yet been performed after 2009. The Study aimed to evaluate the MDA effect against mikrofilaria rate (Mf and antigen circulation in perifer blood of people living near by the elephantiasis individu in Kampung Sawah area, Ciputat, South Tangerang. Periferal blood and blood vessel were collected at night from 08.00–10.00 PM. Peripheral blood were directly swab on slide or object glass to overnight preserve for giemsa stain in laboratory. After night preservation, the slide were then identified by microscope to detect microfilaria. The blood vessel were sentrifuged to collect the serum and performed rapid diagnostic test antigen antifilaria IgG4. Finding result of the study determined 95% Mf negative and 72.5 % negative of antigen anti-filaria IgG4. These finding showed that more than 70% of subjects were negative to filarial and its antigen circulation in the blood.This also indicates successfull program of 4 years MDA in this study area to eliminate parasite of filariasis.

  5. EVALUASI KEBIJAKAN PROGRAM PEMBERANTASAN FILARIASIS DI KABUPATEN TANAH BUMBU PROVINSI KALIMANTAN SELATAN

    Directory of Open Access Journals (Sweden)

    Lukman Waris

    2012-11-01

    Full Text Available Elephantiasis in this lime has still become the problem of trensetter health of society these days. This disease can be catching and have the character of chronical which because of worm of filaria attacking lymph gland and channel causing and lymphangitis of elephantiasis. Borneo South Province, counted 13 Sub-Province/town (100% expressed as Filariasis endemis among others in Tanah Bumbu Sub Province. Target of this research is to know policy of execution of filaria eliminasi in Tanah Bumbu Sub-Province and also applying of strategy of eliminasi mount District and factors which and resistor of PSP society of endemis filariasis. This Research methode is observasional and conducted to organizer of program and also taker of policy of Tanah Bumbu Sub-Province (study qualitative and quantitative study's chosen society by using transversal crosscut Desain study (cross secsional by statistical analysis. Result of research indicate that all taker of policy is not to know surely case picture of filariasis in Tanah Bumbu Sub-Province, so that cannot do resource allocation and over come take action in eradication of filariasis. Result of assessment of knowledge of attitude and behavior of responder, productive age (26-35 year though living many as farmer with education of finish mean of SMA more is owning of knowledge, positive behavior and attitude if compared to other age group. Pursuant to statistical analysis of productive age group at most counselling terpapar by officer of health so that they more is knowing of disease of filaria in general. Key words: filariasis, study policy, tanah bumbu sub province

  6. Ogilvie's syndrome (acute colonic pseudo-obstruction): review of the literature and report of 6 additional cases; Sindrome di Ogilvie (pseudo-ostruzione della letteratura acuta del colon): revisione della letteratura e descrizione di 6 nuovi casi

    Energy Technology Data Exchange (ETDEWEB)

    Grassi, Roberto; Cappabianca, Salvatore; Porto, Annamaria; Montemarano, Emilio; De Rosa, Roberto [Napoli Univ., Napoli (Italy). Dipartimento medico-chirurgico di internistica clinica e sperimentale, Sezione scientifica di radiodiagnostica, radioterapia e medicina nucleare; Sacco, Maurizio; Quantarelli, Mario [Ospedale San Gennaro, Napoli (Italy). Servisio di radiodiagnostica; Di Mizio, Roberto [Ospedale S. Massimo, Penne (Italy). Servizio di radiologia

    2005-04-01

    quale indirizzano noxae patogene diverse, forse interagenti. Descriviamo la nostra casistica comprendente 6 casi di sindrome di Ogilvie raccolti dal 1997 al 2002. Materiale e metodi: Sono giunti alla nostra osservazione 6 pazienti affetti da pseudo-ostruzione del colon nel periodo compreso tra ottobre 1997 e settembre 2002. In 2 casi la pseudo-ostruzione era recidiva. La positivit� dei reperti radiologici per la dilatazione acuta del colon senza ostruzione organica � stato il criterio di inclusione. Risultati: L'esame diretto dell'addome ha evidenziato che la dilatazione del colon era situata in 3 pazienti fino al livello della flessura splenica, in 2 fino alla flessura epatica e in un caso era interessato unicamente il colon trasverso. Nessuno dei pazienti presentava livelli idroaerei del piccolo intestino. Conclusioni: Il reperto clinico pi� caratteristico della sindrome di Ogilvie � la distensione addominale, che generalmente insorge all'improvviso, ha un'andamento progressivo, e raggiunge gradi elevati. L'indagine diagnostica di prima istanza � l'esame radiografico dell'addome, che documenta la dilatazione estrema del colon, in assenza di livelli idroaerei del tenue. Nella nostra casistica in 3 pazienti la sola terapia conservativa ha permesso il ritorno alla normalit� in 5 giorni. In altri 2 pazienti � stato necessario intervenire con una colonscopia decompressiva. in 1 caso la paziente � deceduta dopo 48 ore per arresto cardiocircolatorio.

  7. Amando un boss: la psicologia mafiosa attraverso la voce di un “amante di Cosa Nostra”

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    Roberta Lampasona

    2013-05-01

    Full Text Available Riassunto Il presente lavoro vuole essere un contributo di ricerca volto alla comprensione di alcune caratteristiche dello “psichismo mafioso” al femminile (Lo Verso, 1998, considerato uno specifico e importante spaccato antropo-culturale in Sicilia. Lo studio, inquadrabile come clinico-qualitativo tenterà di aggiungere ulteriori dati conoscitivi al mondo mafioso, attraverso la voce di una donna estranea a Cosa Nostra, ma amante di un boss mafioso dell’agrigentino. La metodologia utilizzata è stata quella dell’intervista semi-strutturata creata ad hoc e mirante a conoscere determinati aspetti passati e presenti della vita del soggetto e a trarne una conoscenza e/o un cambiamento della sua realtà psicologica nel contesto in cui vive. I dati ottenuti dall’intervista sono stati successivamente sottoposti ad un’ analisi qualitativa seguendo il modello della Grounded Theory e attraverso l’ausilio del software Atlas-ti. L’obiettivo del presente lavoro, è quello di estrapolare gli aspetti psicodinamici del fenomeno posto in esame, nel tentativo di comprendere la psiche a partire dall’attenzione posta alle relazioni inconsce della vita psicologica umana. Il vertice di osservazione è quello “gruppoanalitico soggettuale” (Lo Verso, 1989, 1994; Lo Verso, Di Blasi 2011, che vede l’identità soggettiva fondersi sull’asse del rapporto tra universo individuale e universi collettivi. Parole chiave: gruppoanalisi soggettuale; psichismo mafioso; amante. Loving a boss: psychology of mafia through the voice of a lover in Cosa Nostra Abstract The present work is a contribution to research aimed at understanding some features of female "mafia psychism" (Lo Verso, 1998, considered a specific and important anthropological and cultural insight into Sicily. The study, framed as clinical-qualitative, will attempt to add additional cognitive data to the mafia world, through the voice of a female stranger to Cosa Nostra but lover of a mafia

  8. Il Servizio Intercultura dell’Istituto di Terapia Familiare di Firenze

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    Giancarlo Francini

    2013-12-01

    Full Text Available Nel corso del presente articolo vengono descritte le premesse epistemologiche e le metodologie adottate dagli operatori del Servizio Intercultura dell’Istituto di Terapia Familiare di Firenze (ITFF nel lavoro con la popolazione migrante ed elencati gli interventi fatti nel territorio. Il Servizio Intercultura dell’ITFF si è interrogato in questi anni sul valore della cultura come porta d’ingresso nel rapporto con il migrante; nel chiedere loro di narrare aspetti della loro cultura condividiamo aspetti della nostra cultura. L’incontro con il malinteso, che come dice Jankelevitch «(… è un quasi niente» (Jankelevitch, 1987, p. 233, perché se fosse stato qualcosa di più ce ne saremmo accorti e se fosse qualcosa di meno non sarebbe significativo, ci permette di aprirci a un rapporto che cambia entrambi, operatore e migrante, nella relazione. È nella relazione e attraverso il racconto dell’evento migrazione e del ciclo di vita che si costruisce e si cerca un linguaggio comune per la descrizione e l’espressione del disagio. Il lavoro con i migranti deve fare i conti con le difficoltà legate all’impiego, alla casa, al permesso di soggiorno e non ultimo alla brevità di alcuni incontri, perché per alcuni la nostra città è solo una tappa di un percorso che continua alla ricerca di una sistemazione migliore. Nel territorio di Firenze sono stati messi a punto una serie di servizi: oltre alla clinica e a uno sportello di consulenza, ci si dedica alla formazione degli operatori che lavorano con i migranti. Esempi di queste attività sono: un progetto di peer tutoring in alcune scuole superiori, uno di formazione per le assistenti sociali al fine di proporre un protocollo più efficace di presa in carico dei migranti, una serie di focus group con dipendenti Asl all’interno del progetto “Mamma segreta” della regione Toscana; inoltre, la collaborazione con le associazioni presenti sul territorio ha permesso un contatto

  9. Apertura dei lavori

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    Giovanni Renga

    2003-05-01

    Full Text Available

    Questa sessione apre i lavori dell’VIII Conferenza di Sanità Pubblica della nostra Società. Il programma che vi è stato presentato, la sede in cui si svolge, la qualità e la dimensione della vostra partecipazione riconfermano la validità di una formula che si è andata consolidando nel tempo e rappresenta ormai, insieme al Congresso Nazionale biennale, il fiore all’occhiello della ricchissima attività convegnistica della SItI.

    Si conferma anche la straordinaria continuità e coerenza della nostra società scientifica nell’interpretare, a livelli qualitativi sempre più elevati, la propria missione di individuazione, approfondimento e disseminazione della conoscenza necessaria per migliorare l’azione di Sanità Pubblica nel nostro Paese.

    La sessione testimonia questa attenzione! Con il tema della SARS, la Relazione di Pietro Crovari dà conto delle linee di comportamento dell’apparato di sanità pubblica nell’affrontare un problema che ha scosso l’opinione pubblica mondiale risvegliando anche nei paesi più progrediti antiche paure e arcaici pregiudizi; che ha provocato contraccolpi enormi in ambito commerciale ed economico; che ha richiamato l’attenzione su regole e precauzioni tanto scontate da risultare poi in pratica quasi inapplicate. La risposta italiana è stata corretta, impostata sulle conoscenze scientifiche adottate con pragmatico buon senso. Una autorevole presenza della cultura igienistica nelle sedi decisionali ci consente anche di guardare con serenità ai possibili rischi ancora ipotizzabili.

    La partecipazione alla Comunità Europea e l’adesione ai suoi principi e le sue regole stanno producendo una serie di cambiamenti che arriveranno a incidere anche sui nostri modelli di prevenzione. La Relazione di Vittorio Carreri fornirà il punto di vista di uno sperimentato ed attento conoscitore della materia riguardo agli innumerevoli problemi già aperti e su quelli ancora incombenti sul

  10. El ecumenismo y los 50 años del Vaticano II (Ecumenism and the 50th anniversary of Vatican II - DOI: 10.5752/P.2175-5841.2011v9n24p1221

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    Marcelo Barros

    2012-01-01

    Full Text Available ResumenEl artículo recuerda El Concilio Vaticano II a partir del ecumenismo. Trata del ambiente anterior al  Concilio que hizo posible nuevas relaciones ecuménicas. Indica los debates del periodo conciliar relativos a la misión de la Iglesia ante el mundo, a la libertad religiosa y a la relación de la Iglesia con las otras Iglesias, y con otras religiones, debates importantes en la redacción de varios documentos conciliares como  Lumem Gentium, Dei Verbum, Dignitatis Humanae, Nostra Aetate e Unitatis Redintegratio. Paralelamente a los pasos ecuménicos alcanzados por el Concilio, el artículo destaca tres reacciones: (i El nacimiento de una Iglesia latinoamericana cuyo rostro se presenta en las positivas respuestas de las Conferencias del Episcopado latinoamericano, en la efectiva construcción de una Iglesia “pueblo de Dios” y en el “ecumenismo social”; (ii La posterior “restauración eclesiocéntrica”, marcada por la rigidez doctrinal y disciplinar del ambiente católico; (iii La esperanza de un nuevo proceso conciliar, iluminado por la perspectiva liberadora propiciada por el Vaticano II, en el contexto de un mundo diversificado y pluralista.Palabras clave: Concilio Vaticano II. Ecumenismo. CELAM.  Pluralismo AbstractThe article addresses the Second Vatican Council under the focus of ecumenism. In this way, the article mentions the climate, prior to the Council that made possible new ecumenical relations. The text also points out the debates that took place at the time of the Council, especially those connected with the mission of the Church, the freedom of religion, and the relationship of the Church with the other Churches and with other religions. Among others, the article mentions the following documents: Lumen Gentium, Dei Verbum, Dignitatis Humanae, Nostra Aetate and Unitatis Redintegratio. In correlation to the ecumenical steps reached by the Council, the article highlights three reactions: (i The birth of a Latin

  11. Il crimine organizzato in Italia: analisi evolutiva

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    Elena Bianchini

    2007-12-01

    Full Text Available In Italy, organized crime presents today some specific characteristics : traditional for the existence of ancient roots from particular regions; new for the kind of illegal activities in which organized crime is involved and which is always changing and spreading making international alliances.In Italy, with specific attention to endogenous crime, the last Report on Crime underlines that “the more structured criminal alliances, such as cosa nostra, ‘ndrangheta, camorra and Apulian organized crime , keep on exerting an effective control effect in their original territories and so they are also a very serious threat for the development of relationships between the social components and also for the economy”. This is an alarming situation which requires urgent, preventive, istitutional and social action. The results from the present research are based on the reading and the analysis of the inaugural addresses of judicial years ( 2000-2007.Aujourd'hui en Italie, la criminalité organisée présente des caractéristiques particulières : traditionnelles, en raison de l'existence d'anciennes racines dans certains contextes régionaux ; nouvelles, à cause de la typologie d'activités illicites accomplies ; expansives, par l'aptitude à tisser des alliances transnationales. À propos de la criminalité endogène, le dernier Rapport sur la Criminalité en Italie souligne que "les associations criminelles les plus structurées, cosa nostra, 'ndrangheta, camorra et criminalité organisée des Pouilles, continuent à exercer une action de contrôle efficace des territoires d'origine et à menacer gravement le développement des relations parmi les différentes composantes sociales et de l'ordre économique". L'analyse ici présentée aussi, concernant les rapports inauguraux des années judiciaires (2000-2007, trace un cadre alarmant qui exige des interventions urgentes à niveau préventif, institutionnel et social.

  12. Espectro polínico de amostras de mel de Apis mellifera L., coletadas na Bahia Pollen spectrum of samples of Apis mellifera L., honey collected in Bahia State, Brazil

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    AUGUSTA CAROLINA DE CAMARGO CARMELLO MORETI

    2000-01-01

    Full Text Available O espectro polínico encontrado em amostras de mel provenientes de seis municípios do Estado da Bahia foi analisado com o objetivo de contribuir para o conhecimento da flora visitada por Apis mellifera L. 1758 (Hymenoptera: ApidaeA identificação dos tipos polínicos foi feita por meio de literatura especializada e de informações de campo. Foram encontrados 43 tipos de pólen, sendo consideradas como dominantes as espécies Eucalyptus sp. (Myrtaceae, Mimosa verrucosa Benth. (Mimosaceae, M. scabrella Benth. (Mimosaceae e Bauhinia sp. (Caesalpiniaceae. Os tipos acessórios foram Alternanthera ficoidea R.Br. (Amaranthaceae, tipo Compositae (Asteraceae e Cecropia sp. (Moraceae. Destacou-se a participação de Mimosa sp. (Mimosaceae e de outras espécies silvestres na composição dos méis nos municípios considerados, registrando-se ainda a espécie Eucalyptus sp. (Myrtaceae como uma das principais fontes de alimento das abelhas dessa região.Pollen spectrum found in honey samples from six localities of Bahia State, Brazil, was analyzed with the objective to contribute for the knowledge of the plants used by Apis mellifera L., 1758 (Hymenoptera: Apidae. The identification of the pollen types was made by specialized literature and by field information. Two hundred pollen grains were studied in order to determine the percentage and the occurrence of each type. Forty three pollen types were identified, being considered as the predominant types Eucalyptus sp. (Myrtaceae, Mimosa verrucosa Benth. (Mimosaceae, M. scabrella Benth. (Mimosaceae and Bauhinia sp. (Caesalpiniaceae. The accessory pollen types were Alternanthera ficoidea R.Br. (Amaranthaceae, Compositae type (Asteraceae and Cecropia sp. (Moraceae. It is intense the participation of Mimosa sp. (Mimosaceae and other wild species in the honey composition of the six localities considered. Eucalyptus sp. (Myrtaceae is one of the dominant sources of bee food in some regions of Bahia State.

  13. Neglected tropical diseases, neglected data sources, and neglected issues.

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    Burton H Singer

    Full Text Available BACKGROUND: Lymphatic filariasis (LF is a so-called neglected tropical disease, currently overshadowed by higher-profile efforts to address malaria, tuberculosis, and HIV/AIDS. Despite recent successes in arresting transmission, some 40 million people who already have the disease have been largely neglected. This study aims to increase understanding of how this vulnerable, neglected group can be helped. METHODS: We used purposive sampling to select 60 men and women with filarial lymphoedema (45 with filarial elephantiasis and 15 men with filarial hydrocoele from the south of Sri Lanka in 2004-2005. Participants were selected to give a balance of men and women and poor and nonpoor, and a range of stages of the disease. Participants' experiences and the consequences of their disease for the household were explored with in-depth qualitative, semistructured interviews. FINDINGS: LF was extremely debilitating to participants over long periods of time. The stigma attached to the condition caused social isolation and emotional distress, and delayed diagnosis and treatment, resulting in undue advancement of the disease. Free treatment services at government clinics were avoided because the participants' condition would be identifiable in public. Loss of income due to the condition was reported by all households in the sample, not just the poorest. Households that were already on low incomes were pushed into near destitution, from which it was almost impossible to escape. Affected members of low-income households also had less opportunity to obtain appropriate treatment from distant clinics, and had living and working conditions that made hygiene and compliance difficult. SIGNIFICANCE: This highly vulnerable category of patients has low visibility, thus becoming marginalized and forgotten. With an estimated 300,000 total cases of elephantiasis and/or oedema in Sri Lanka, and around 300,000 men with filarial hydrocoele, the affected households will need

  14. eBook: Temps líquids per a les biblioteques públiques

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    Juan Soriano, Emili

    2012-06-01

    Full Text Available Què fem amb els llibres electrònics?, és la pregunta que s’estan plantejant molts bibliotecaris mentre assisteixen perplexos a una competició frenètica sobre la distribucióde continguts digitals i a la cursa accelerada de les empreses tecnològiques per presentar dispositius de lectura electrònica amb més prestacions.La resposta no és senzilla, per això, les biblioteques públiques contemplen aquesta nova realitat amb un cert neguit, i alhora, com un nou repte per continuar sent una institució cultural central en la vida de les persones posicionant-se i adaptant els serveis i els continguts a les noves demandes dels usuaris, tenint present que, a dia de hui, el món digital i el món imprès no són excloents sinó complementaris.El present article intenta analitzar aquesta nova realitat i planteja algunes de les accions a adoptar per part de les biblioteques públiques amb les incerteses pròpies dels “tempslíquids” que travessa la nostra societat.

  15. The influence of spatial effects on the measurement results of reactivity in 'fast disturbances' of core parameters

    International Nuclear Information System (INIS)

    Tsyganov, S.V.; Shishkov, L.K.

    2001-01-01

    The analysis of methods for the determination of reactivity revealed an essential influence of spatial effect on the measurement precision. Using of reverse point kinetic equation for reactivity meter is assumed that the average neutron flux weigh with the importance function is known at every moment of the transient. In fact, reactivity meter represent behaviour of the neutron flux only of the part of the core, so measured value of reactivity can differ from really reactivity. Three-dimensional dynamic model of the core allow to evaluate such difference. It is supposed to evaluate correction factor for the neutron flux measured at the place where ion chamber situated with the three-dimensional model NOSTRA of the WWER core. On the basis of such algorithm we propose to build module allowing the influence of spatial effects on the results of the reactivity meter to be eliminated at real time regime. This code will be incorporated into the core monitoring system 'BLOK' (SCORPIO type) which is being developed for the Kola and Rostov NPP. The report illustrates utilization of such algorithm (Authors)

  16. MUSICA E MUSICOTERAPIA

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    Fulvio Šuran

    2014-01-01

    Full Text Available Perché la musica piace? Molte sono le possibili risposte a tale quesito, nessuna però del tutto soddisfacente. Comunque, di certo nessuno avrà da ridire se si risponde con un “perché fa bene”, poiché tale risposta sintetizza un po’ tutte le implicazioni della questione, siano esse di ordine biologico, psicologico, sociologico, estetico o etico. In questo senso le relazioni fra educazione generale, educazione musicale e musicoterapia sono assai strette. Ed è nostra intenzione richiamare l’attenzione su di esse, mostrando che la funzione terapeutica non è una questione semplicemente marginale o accessoria dell’educazione, ma qualcosa di ben più rilevante. Per cui è inconcepibile che ancor oggi si possa pensare ad una compiuta educazione, nella quale la musica non sia in onore. Di più, è impensabile un’educazione priva di spirito musicale, inteso come disposizione ad accogliere e ad esprimere, in ben temperata armonia, pensieri ed azioni.

  17. Un solo universo o infiniti universi ?

    CERN Document Server

    Davies, Paul

    1998-01-01

    Presentato dal Washington Times come "il miglior scrittore di scienza sulle due sponde dell'Atlantico", Paul Davies conferma con questo libro la sua fama di imbattibile divulgatore scientifico. Fin dalle prime pagine il lettore dimentica le vesti accademiche del professore universitario e si lascia catturare dal vivace racconto delle sfide, vecchie e nuove, della scienza. Davies traduce i concetti più complicati in un linguaggio semplice e focalizza l'attenzione sui grandi temi della cosmologia e dell'astronomia: la possibilità, aperta dalla fisica moderna, della coesistenza di più "universi", il viaggio nel tempo, i buchi neri, la gravità quantistica, il rapporto tra scienza e religione. La tensione didattica e la grande vocazione comunicativa sono le due anime di quest'opera, che ha tutti i crismi del lavoro scientifico e il ritmo appassionante della narrativa. Chi legge Davies può imparare divertendosi e scoprire attraverso la scienza che la nostra esistenza ha un senso.

  18. Le strutture dell'immaginazione. Un disegno di John Hejduk / Structures for the Imagination. A John Hejduk's drawing

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    Lamberto Amistadi

    2014-05-01

    Full Text Available Un disegno di John Hejduk è l'occasione per riflettere sul rapporto tra ideazione, rappresentazione e realizzazione dell'opera di architettura, seguendo i ragionamenti del maestro americano. Attraverso i mezzi che le sono propri, walls, roofs, boundaries, l'immagine architettonica ha la capacità di evocare e richiamare il senso profondo di situazioni inattese, “rinfrescare” la nostra visione delle cose contro il pericolo dell'automatizzazione. Ne esce un quadro in cui, nel circolo creativo che coinvolge artefice e fruitore, la realtà dell'architettura contribuisce per la sua parte al progetto di “fabbricazione del mondo”. / A drawing by John Hejduk is an opportunity to reflect on the relationship between the creation, representation and realisation of a work of architecture, following the reasoning of the American maestro. Through its own means - walls, roofs, boundaries - the architectural image has the capacity to evoke and invoke the profound sense of unexpected situations, to "refresh" our vision of things against the danger of automation. What emerges is a scenario in which, in the creative circle involving maker and spectator, the reality of architecture contributes to its part in the project of "manufacturing the world"

  19. Parallela, a.c. di/Hrsg. Roland Bauer e Hans Goebl, Testo - Variazione - Informatica / Text ž Variation - Informatik, Atti del IX incontro italo-austriaco dei linguisti (Salisburgo, 1-4 novembre 2000 / Akten des IX. österreichisch-italienischen Linguiste

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    Pavao Tekavčić

    2003-12-01

    Full Text Available I sottotitolo stesso del presente volume dice che i contributi appartengono ai domini piu attuali della linguistica. I 26 contributi sono raggruppati nelle seguenti tre sezioni (entro ciascuna i nomi degli autori in ordine alfabetico: 1. Linguistica variazionale/Variationslinguistik. (13 contributi, 2. Linguistica testuale/Textlinguistik (10 contributi, 3. Linguistica computazionale/Computerlinguistik (3 contributi. La miscellanea si apre con la Prefazione dei curatori/Vorwort der Herausgeber (V-V11I, seguita dall'Indice tematico/Thematisches Inhaltverzeichnis (IX-XI e dagli lndirizzi elet­ tronici (E-Mail Adressen degli autori e dei curatori. Dei 26 testi 21 sono in italiano e 5 in tedesco. In seguito presentiamo, in forma quanto piu succinta, i contributi, citando gli autori con le relative sedi (tra parentesi e le pagine (anche queste tra par­entesi, ma omettendo per brevita i titoli (alcuni abbastanza  lunghi.  La numer­ azione  dei contributi (13 + 10+3 e nostra.

  20. Concept of Gesamtkunstwerk in Ivan Meštrović’s oeuvre: at the intersection of art, politics, religion and self-reflection / Il concetto di Gesamtkunstwerk nell’opera di Ivan Meštrović: all’intersezione di arte, politica, religione e autoriflessione

    Directory of Open Access Journals (Sweden)

    Dalibor Prančević

    2017-12-01

    In questo intervento sono esaminati tre progetti architettonico-scultorei di Ivan Meštrović, nei quali è visibile la comprensione e l’applicazione della Gesamtkunstwerk, intesa come una forma particolare di partecipazione alla creazione artistica: il Tempio di Vidovdan, la Chiesa di Nostra Signora degli Angeli a Cavtat e la Chiesa del Santissimo Redentore a Otavice. Nell’articolo viene analizzato fino a che punto il protocollo della Gesamtkunstwerk sia veramente importante per l’interpretazione delle realizzazioni architettoniche di Meštrović. Inoltre, viene spiegato e dimostrato quanto Meštrović, come nessun altro artista del modernismo in Croazia, abbia riunito la progettazione architettonica e quella scultorea – fino ad allora quasi sempre scollegate – in un’unità artistica indissolubile, inserendole in seguito nello spettro di differenti e problematici contesti sociali, politici, religiosi o autoriflessivi. Nell’intervento, quindi, viene mostrato come la natura del protocollo della Gesamtkunstwerk cambi da un edificio impiegato per l’attivismo politico, prima e durante la prima guerra mondiale, fino ai luoghi sacrali e memoriali di natura più riflessiva, costruiti dopo la guerra e negli anni Venti. È importante rilevare come venga abbandonata l’interpretazione dell’«opera d’arte totale» come questione esclusivamente estetica, predeterminata dalla concezione dell’art pour l’art, e come a questa vengano aggiunte altre funzioni dell’opera nel suo più ampio contesto sociale, storico-politico e religioso.

  1. La restituzione virtuale dell’architettura antica come strumento di ricerca e comunicazione dei beni culturali: ricerca estetica e gestione delle fonti

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    Stefano Borghini

    2011-12-01

    Full Text Available Raffaello Sanzio intuì per primo che il mondo antico, come lo vedevano i suoi occhi, non era che l’eco sbiadita di quella ricchezza che pur doveva caratterizzarne l’esperienza artistica. Oggi la tecnologia permette di realizzare il sogno di Raffaello e di restituire le immagini delle antiche architetture, rivoluzionando la percezione del patrimonio culturale da parte del pubblico moderno. La nostra esperienza decennale nel settore della comunicazione del bene culturale ha consentito di confrontarci con diversi casi: dalla Domus Aurea, all'Ara Pacis; dai filmati divulgativi agli applicativi pensati per le postazioni fisse dei musei, fino alla creazione di software per la gestione dei dati degli scavi archeologici. Sempre ponendo al centro di ogni lavoro i cardini del nostro modo di fare ricerca: l'attenzione al linguaggio, quale strumento di comprensione estetica, e la gestione informatizzata delle fonti, come apparato di studio e metodo di validazione scientifica delle ricostruzioni.[L’impostazione del saggio è comune ai due autori. In particolare, però, Stefano Borghini ha curato il paragrafo “Considerazioni generali”, mentre Raffaele Carlani “Alcune esperienze”].

  2. SPND detectors response at the control rod drop in WWER-1000. Measurement and modelling results

    International Nuclear Information System (INIS)

    Mitin, V.; Milto, N.; Shishkov, L.; Tsyganov, S.; Kuzmichev, M.

    2006-01-01

    The paper analyzes and discusses possibility of neutron flux inspection in the WWER core during fast dynamic processes applying existing in-core monitoring system. The structure and functions of the system, basic principal of detector functioning and its temporal parameters are described briefly. To assess the ability of such dynamic monitoring the event with control rod drop happened during operation of Kozloduy NPP Unit 5 is observed - at the level of power close to nominal one of the rod from control group shifted to the lowest position at-2 seconds. In-core detectors readings at the process were registered and processed with mathematical methods that allow to single out only the prompt part of the signal. Results of the processing are presented. Furthermore, the process observing have been modeled with 3D dynamic code NOSTRA. Results of modeling are presenting in a paper, and comparing with experimental ones. A good agreement achieved. The analysis of measurements and its imitation give a hope that with an aggregate signal of detectors the measurement of control rod worth could be provided, and it allows to avoid of influence of spatial effects that are significant at standard technique with ex-core ion chambers (Authors)

  3. Black Mirror: “The National Anthem”. Arte, media e la dissoluzione della democrazia

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    Pierluigi Musarò

    2014-12-01

    Full Text Available Black Mirror è una serie televisiva britannica che, con irriverente satira, ci mette di fronte al “lato oscuro” della tecnologia odierna, l’assuefazione da essa causata, gli effetti inquietanti sulle nostre vite. Riprendendo il tema del nostro disagio contemporaneo con molti decenni di distanza, i sei episodi della serie televisiva, pur ambientati in “realtà” differenti, sembrano, come uno specchio, metterci di fronte alla nostra esistenza, costringendoci a riflettere – in modo amaro e a tratti macabro – sul nostro stile di vita, sulle nostre emozioni e relazioni, sino al nostro modo di intendere e praticare la politica nell’attuale società dello spettacolo. In questo saggio viene analizzato il primo episodio, The National Anthem, un thriller politico tragicomico, con toni da apocalisse, attraverso cui  l’autore denuncia come essere di fronte allo schermo (piuttosto che nello schermo, spendendo buona parte delle nostre giornate all’interno di mondi virtuali dove mettiamo in atto le nostre performance, non abbia più nessuna forza moralizzatrice se non quella dell’auto-espressione spettatoriale.

  4. Vitalij L. Machlin, Dopo l'interpretazione

    Directory of Open Access Journals (Sweden)

    Margherita De Michiel

    2010-12-01

    Full Text Available Una riflessione insieme lucida e accorata sulla contemporaneità umanistico-scientifica oggi, in Russia come in occidente, in un’epoca che si confronta con l’esperienza del «dopo» a molteplici livelli del «mondo della storia» e del «mondo della vita». Approcci a un’«epistemologia umanistica» come «filosofia della seconda coscienza», ermeneutica dialogica che è insieme filosofia del linguaggio e ontologia sociale. La postulazione di una nuova «filologizzazione della filosofia» che riproponga il genere discorsivo del «commento» nella sua duplice anima della «comprensione» e della «spiegazione».  Nella nostra epoca «postbarbarica», la ripresa di un discorso interrotto per una nuova disputa tra «antichi» e «moderni». La parola di un filosofo, e il suo appello a un ritorno alla valenza etica dell’insegnamento.

  5. Note di fotonica

    CERN Document Server

    Degiorgio, Vittorio

    2012-01-01

    L’invenzione del laser ha generato una vera rivoluzione nella scienza e nella tecnologia e ha dato luogo alla nascita di una nuova disciplina chiamata Fotonica. Le più importanti applicazioni della Fotonica che hanno un impatto cruciale in molti ambiti della nostra vita sono le comunicazioni in fibra ottica su cui si basa il funzionamento di Internet e del traffico telefonico su grandi distanze, i dischi ottici (CD, DVD, Blue-ray), la sensoristica ottica di tipo industriale e ambientale, la lavorazione dei materiali, l’illuminazione con i LED e la chirurgia. Questo volume ha come obiettivo quello di colmare un vuoto nel panorama italiano di testi universitari riguardanti la Fotonica. Lo scopo principale è quello di esporre in modo sintetico ma rigoroso i concetti che stanno alla base del funzionamento del laser e della propagazione della luce nella materia, e di descrivere i principali componenti e dispositivi ottici e optoelettronici, quali le fibre ottiche, gli amplificatori, i modulatori e i rivelato...

  6. Dal mondo del pressappoco all'universo della precisione

    CERN Document Server

    Koyré, Alexandre

    1992-01-01

    I temi affrontati in questo libro da uno dei più autorevoli storici della scienza, Alexandre Koyré, sono oggetto di un vivace interesse da parte della nostra cultura. Koyré discute qui l'origine, la natura e la valutazione delle macchine e degli strumenti scientifici, considerati nei loro riflessi umani e sociali, più ancora che nelle loro caratteristiche tecniche. La sua analisi chiarisce i termini di alcune questioni fondamentali per la storia della tecnologia e della scienza, e del loro rapporto storico; perché ad esempio la scienza greca, scopritrice di fondamentali principi poi applicati trionfalmente dalla fisica moderna, non abbia cercato di tradurli in innovazioni tecniche; perché i notevolissimi ritrovati tecnici delle civiltà orientali e del Medioevo abbiano fallito a questo scopo; perché la rivoluzione scientifica dell'età moderna ci abbia dato col suo concetto dell'esperienza gli strumenti che sono alla base della civiltà industriale; quale sia infine il rapporto tra tecnica e scienza pu...

  7. Il potere euristico dell’agapismo nella filosofia di Peirce

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    Ivo Assad Ibri

    2013-10-01

    Full Text Available La prima parte di questo saggio offre un’analisi del testo “La legge della mente”, in cui Peirce teorizza il potere di crescita e diffusione delle idee e formula la sua risposta alla classica domanda riguardo al modo in cui la mente possa influenzare la materia. A partire da un’analisi centrata sul duplice significato semantico della parola "affetto", il lavoro intende mostrare come la rottura da parte di Peirce con il dualismo cartesiano di mente e materia conduca a una sostanziale identità tra idealità e realtà per mezzo di una fusione metafisica di realismo e idealismo, in cui la materia viene considerata esclusivamente come un caso particolare della mente. La seconda parte mostra come le diverse forme di evoluzionismo discendano dalle tre categorie, ponendo in evidenza il concetto di agapismo, la dottrina dell’amore cosmico e creativo. Nella parte finale viene mostrato come il legame tra realismo e idealismo, così come le considerazioni di Peirce sull'evoluzionismo, costituiscano aspetti essenziali in vista di una giustificazione del successo storico della nostra capacità umana di elaborare congetture, ovvero di proporre ipotesi di successo per spiegare i fatti.

  8. "A chiare lettere" Editoriale gennaio 2007

    Directory of Open Access Journals (Sweden)

    Giuseppe Casuscelli

    2011-02-01

    Full Text Available Ad onta delle crisi ricorrenti che investono il diritto ecclesiastico, nell’anno appena iniziato la nostra disciplina raccoglie il testimone inatteso della speranza. Il 2006 ci ha offerto la pubblicazione di tre manuali1 che, con un taglio ed un’impostazione nuovi, si rivolgono ad un’utenza che non è fatta soltanto degli studenti delle nostre Università; la pubblicazione del primo numero della nuova rivista semestrale “Diritto e Religioni”2, che intende trattare il fattore religioso da molteplici punti di vista aprendosi ad una molteplicità di scienze affini (antropologia, sociologia, storia, filosofia; la nascita di questa rivista telematica che non vuole avere un proprio indirizzo o orientamento, ma si prefigge lo scopo di essere strumento e manifesto della pluralità e del pluralismo delle scuole, delle sensibilità, dei metodi che alimentano il patrimonio comune del sapere teorico perché in esso trovi a sua volta alimento il concreto, quotidiano farsi dell’esperienza giuridica. Due ricorrenze di particolare rilievo segnano, ancora, questa fase: i cinquanta anni della Corte costituzionale, alla cui attività molto è legato il rinnovamento del “diritto ecclesiastico”, che ha partecipato alla celebrazione corale offrendo uno specifico contributo di analisi della sua giurisprudenza 3; i dodici lustri della Costituzione repubblicana, un’età “matura” che offre l’occasione per un bilancio della sua vitalità, delle compiute attuazioni, delle attese non ancora realizzate.

  9. Ancora sulla coordinazione di indicative e congiuntivo nelle “Satire” dell'ariosto

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    Mario Medici

    1984-12-01

    Full Text Available In"Lingua nostra" (XLII, 1981, pp. 43-44 mi sono occupato degli aspetti linguistici ed espressivi dei casi di coordinazio­ ne   di indicativa e congiuntivo in proposizioni dipendenti, ri­ scontrati nelle satire di Ludovico Ariosto: essi, tutti, trova­ no conferma testuale nella recente edizione critica, a cura di Cesare Segre, pubblicata nella collana mondadoriana di tutte le opere ariostesche (vol. III, Hilano 1984. Qualcosa tuttavia si può ora aggiungere e osservare più largamente, tenendo canto dell' apparato posto a piè di pagina, che viene a dimostrare ancora una volta la possibilita (che qui si presenta anche come "variantistica" di usi alternativi di indicativa e congiun­tivo in determinati sintagmi, tendendosi nel nostro caso speci­ fico in genere, con la diversa o mutata lezione, a un pareggia­ mento modale con conseguente livellamento a scapito di funzioni o valori espressivi. Alla compresenza articolat.i dei modi diver­si, alla più generale tendenza al congiuntivo, ben è  affidata la "sottigliezza" formale, stilistica ed espressiva della poesia ariostesca.

  10. Una inedita versione càrnica ottocentesca della parabola del figliuol prodigo

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    Giovanni Frau

    1984-12-01

    Full Text Available Fra i manoscritti deila Biblioteca Comunale di Bassano· del Grappa è custodita - insieme con altre ·""' una inedita versione carilica delia Parabola del Figliuol prodigo, proveniente dall' "Epistolario racccolto da Bartolomeo Gamba" (con la collocazione numero 2589 XVII-"A-ll, un erudite locale, vissuto frail 1766 e il 1841. Essa devette far parte·""' con le altre - di quella silloge di versidni friulane,  che Pietro Oliva del Turco di Avia­no aveva commissionato a corrispondenti locali per canto di Bernardino Biondeili, il note autore del saggio sui dialetti ·· gallo-italici Milano 1853,·il quafetuttavia non vi inserì le versioni della nostra Regione: alla loro pubblicazione provvide - riprendendole dai manoscritti delle-stesso, rimasti inediti - Carlo Salvioni con le Versioni  friulane della Parabola  del;Figliuol prodigo tratte dale carte Biondeili, in "Memorie Stori­ che Forogiuliesi"t IX (1913}, pp. 80-95;

  11. Pensar la in/visibilitat. Papers de treball

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    Meri Torras

    2011-01-01

    Full Text Available Aquest text recull uns papers de treball al voltant de la in/visibilitat, amb el propòsit de revisar una categoria que ha creuat la trajectòria d’existència lèsbica, gai, queer, així com la teorització i el pensament a propòsit d’aquestes subjectivitats (i de la seva pròpia subjecció. L’associació de la visibilitat amb l’existència ha constituit un axioma. No obstant, la visibilitat no és sempre necessàriament la millor manera de fer-se visible o, immediatament, la millor estratègia política per a l’afirmació de la nostra existència. En aquests papers de treball parteixo de la formulació d’unes hipòtesis/propostes de reflexió, per continuar dialogant amb el volum Manifiestos gays, lesbianos, queer. Testimonios de una lucha (1969-1994, editat per Rafael M. Mérida, i acabo amb un breu testimoni de l’escriptora catalana Maria Mercè Marçal.

  12. Il corpo della strega

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    Georges Bertin

    2004-09-01

    Full Text Available Come già evidenziato a proposito di altre pratiche, il sabba, attività ludica profana, religiosa, conferiva a ciascuno la possibilità di giocare efficacemente con la dinamica di un mondo da cui emergeva una figura archetipica, la strega, principale attore di questa danza in tondo. Il sabba era, dunque, uno dei luoghi ove si cristallizzavano le figure del proibito, questo per il suo carattere sacro, per la violenza istituzionale che presiedeva alla formazione dei rapporti sociali, e conferiva anche, per le caratteristiche di protesta che rivela, un'immagine sempre esaltante della capacità delle società a resistere. Il problema della nostra epoca ove rifioriscono le streghe nelle più svariate forme è, forse, quello di riallacciarsi con la dimensione gruppale dei nostri svaghi, nelle loro differenti forme e, contemporaneamente, con perdita di energia, a quanto presiedeva ai sabba e alla loro risoluzione sacrificale. In contro-corrente ai modelli meccanici che assegnano dei limiti precisi e funzionali ai corpi asserviti ad un ideale di controllo, il corpo sabbatico con la sua enfasi sulle posizioni limite (ciò che si rimproverava d'altronde alle streghe, era veramente corpo mistico.

  13. Interreligious Dialogue: A Roman Catholic Perspective

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    Gregory Baum

    2011-01-01

    Full Text Available To promote peace, justice and freedom in a deeply divided world, the Catholic Church at Vatican Council II promulgated the declaration Nostra aetate in 1965,expressing its respect for the world religions and recommending dialogue and cooperation with their followers. This was a startling event, since from its very beginning the Catholic Church, and in fact all the Christian Churches, wanted to convert the entire world to the Christian faith. Nostae aetate also transformed the relationship of the Catholic Church’s to Jews and Judaism. This innovative teaching has raised theological questions that have not yet been fully answered. A certain lack of clarity has allowed some conservative Catholics to pretend the Church has not changed its mind. The present paper examines the new teaching in regard to Judaism and the world religions and record the gradual turn to greater openness on the part of Cardinal Ratzinger/Benedict XVI. That interreligious dialogue is capable of transforming the participants. Since religions also have a dark side, at times legitimating unjust regimes or fostering contempt of outsiders, it will be argued that that interreligious dialogue must also listen to the critical thinkers of the Enlightenment.

  14. Moneta e Credito: storia e prospettive di una rivista (Money And Credit: History And Prospects Of A Magazine

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    Alessandro Roncaglia

    2009-12-01

    Full Text Available Con questo numero speciale si apre una nuova stagione della storia della nostra rivista. In una fase di ristrutturazioni interne, la Banca Nazionale del Lavoro ha concordato la cessione della proprietà della rivista stessa e della sua consorella Quarterly Review all' Associazione Paolo Sylos Labini, mantenendo un collegamento tramite una sponsorizzazione. In questo modo è stato possibile salvare due riviste con una storia lunga e prestigiosa, conservandone intatto l'orientamento verso la ricerca e il dibattito scientifico nel campo della teoria e della politica economica, con attenzione particolare ma non esclusiva per gli aspetti monetari e finanziari e senza alcuna preconcetta scelta di campo tra le diverse scuole di pensiero. With this special issue opens a new era in the history of our magazine. In a period of internal restructuring, the Banca Nazionale del Lavoro agreed on the transfer of ownership of the magazine itself and all of its sister Quarterly Review 'Association Paolo Sylos Labini, while maintaining a connection via a sponsorship. In this way it was possible to save two magazines with a long and prestigious history, keeping intact the orientation towards research and scientific debate in the field of economic theory and policy, with particular but not exclusive attention to the monetary and financial aspects and without any preconceived choice of field between the different schools of thought.  JEL Codes: E44, G01 

  15. La materia dei sogni Sbirciatina su un mondo di cose soffici (lettore compreso)

    CERN Document Server

    Piazza, Roberto

    2010-01-01

    Dall’aria che respiriamo ai cibi di cui ci nutriamo, dai vestiti che indossiamo ai detersivi con cui li laviamo, dai colori con cui dipingiamo agli schermi su cui li guardiamo, la nostra realtà quotidiana brulica di cose troppo piccole per essere viste, ma pur sempre enormi rispetto ai mattoni di cui è fatto il mondo, gli atomi e le molecole. Oltre ad essere alla radice di molte tecnologie di oggi e di domani, questi piccoli personaggi, ingredienti primari di quelli che gli scienziati chiamano "materiali soffici", "sistemi sovramolecolari", o " fluidi complessi", ci permettono anche di esplorare i segreti con cui la materia si organizza spontaneamente, perché anche la Vita altro non è se non l’apoteosi di questa incredibile "Terra di Mezzo", a metà strada tra le molecole e l’Uomo. Sfruttando l’esperienza scientifica accumulata dall’autore nel corso di molti anni, questo libro si propone di guidare il lettore attraverso un lungo, ma non troppo faticoso viaggio nel mondo delle nanoparticelle, dei...

  16. From The Count of Montecristo to The Bethroted (to say nothing of Melissa: Italy and television serials during the Sixties

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    Achille Campanile

    2016-06-01

    Full Text Available Come Gianluigi Rossini spiega nel libro Le serie TV, e come questo numero illustra, le tante diverse forme di serialità narrativa hanno via via creato tante diverse forme di dipendenza. Ma una delle più memorabili resta quella innescata dai cosiddetti “sceneggiati” che la nostra Rai manda in onda tra gli anni Cinquanta e i Settanta, dipendenza vissuta pressoché da tutti con la stessa assolutezza, cerimonia laica, passione (e non di rado ossessione condivisa negli stessi tempi e modi: non solo la fiction di turno spadroneggia indisturbata (oltre a non avere concorrenti alla sua altezza, la televisione consiste fino al 1961 in un  solo canale, in due fino al 1979, ma inoltre sprigiona, diversamente dai quiz e dai festival, il fascino garantito del mondo immaginario; e d’altra parte, diversamente dai libri, dai film stessi (e, ovviamente, dalle serie attuali, permette alla collettività di scivolare in questo mondo in simultanea, lo distilla con cadenze regolari nella quotidianità della nazione.

  17. El perfil de l’emprenedor social de l’estudiantat dels Graus d’Educació Social, Pedagogia i Treball Social a la Universitat de Barcelona

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    Olga Cabrera-Santacana

    2014-01-01

    Full Text Available En el context de crisi actual, cada vegada més, es posa més atenció a un tipus d'economia més sostenible i amb valors socials, i la Universitat ha de reconèixer la seva responsabilitat en aquests nous reptes. Durant els darrers cursos acadèmics compresos entre 2010 i 2012, i amb el suport econòmic del projecte REDICE 2010, s'ha analitzat i identificat les necessitats formatives del perfil emprenedor social del nostre alumnat de la Facultat de Pedagogia, s'ha pogut anar introduint el concepte d'Emprenedoria social dins dels Graus d'Educació Social, Pedagogia i Treball Social a través de bones pràctiques que formin perfils universitaris creatius i innovadors per a l’emprenedoria social. Com a resultat d'aquesta anàlisi es mostra un interès per l'emprenedoria social i per unes necessitats acadèmiques per millorar la nostra activitat docent, buscant bones pràctiques identificades en aquesta línia per millorar la formació i docència en relació l'emprenedoria social.

  18. Il Registro della confraternità dei pellicciai di Udine. A cura di Federico Vicario. Biblioteca di Lingua e Letteratura friulana, 4. - Forum, Editrice Universitaria Udinese, Udine 2003; pp. 204

    Directory of Open Access Journals (Sweden)

    Mitja Skubic

    2004-12-01

    Full Text Available L'edizione, in una veste tecnicamente impeccabile, ha come scopo principale quello di presentare i1 registro di una importante confraternita udinese del tardo Medioevo, quella dei pellicciai. In questo ambiente climatico tale mestiere deve esse­ re stato importante; e vedrei una prova nel fatto che viene menzionato, a parte gli beçars - macelatores (es. 42, l'unico, negli Esercizi di versione dal volgare friulano in latino nel sec. XIV in una scuola notarile cividalese dove si legge: L'ager gait, qual è d'estat, fas spargna lis pliçis, chosa ricrisint agl piliças. Ager calidus, qualis est in estate, facit parsimonucare renones, re cuius tedet pelixarios, (es. 40. Il curatore della pubbli­ cazione del Registro, Federico Vicario, vanta già una decina di pubblicazi.oni di testi analoghi e con l'attuale ha aggiunto un ulteriore testo prezioso per la nostra cono­ scenza del friulano antico. Il Registro è l'elenco dei censuari, però, oltre ad essere un documento della vita e dei rapporti sociali del Tre- e Quattrocento, offre un quadro linguistico del friulano in un'epoca in cui la letteratura vera e propria in friulano offre  poco.

  19. Alcune considerazioni sulla relazione insegnante e allievo disabile: Analisi di un’esperienza

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    Anna Maria Disanto

    2015-12-01

    Full Text Available Obiettivo principale del nostro contributo è individuare e qualificare, all’interno della relazione educativa con l’allievo portatore di handicap, l’insieme di contenuti non immediatamente accessibili alla coscienza, che si rivelano solo una volta superate delle resistenze. Il rilievo di questi aspetti è stato possibile attraverso la elaborazione di un questionario cui ognuno ha risposto liberamente, garantito dal più assoluto anonimato. La significatività numerica del materiale a nostra disposizione (134 questionari, ci ha permesso di proporre delle considerazioni che, senza avere la pretesa di essere esaustive, risultano valide per introdurre delle riflessioni sull’argomento.Le riflessioni che presentiamo hanno avuto come occasione di stimolo e di riflessione un corso di formazione per insegnanti di sostegno della scuola dell’obbligo, nella cui impostazione si è cercato di integrare elementi presenti su un piano di realtà con aspetti relativi ad un livello inconscio. Quella che presentiamo è l’elaborazione finale di dati che analizzeremo non quantitativamente ma sul piano dei contenuti, attraverso il riconoscimento dei meccanismi di identificazione che intervengono nella relazione dell’insegnante con il bambino portatore di handicap: come si specifichi, cioè, il processo psicologico per cui si fanno propri elementi caratteristici, attributi di un’altra persona e ci si trasforma, totalmente o parzialmente, sul modello di quest’ultima.

  20. Elettrodinamica classica

    Science.gov (United States)

    Lechner, Kurt

    Nella scoperta della Relatività Ristretta l'Elettrodinamica, rappresentando una teoria relativistica per eccellenza, ha giocato un ruolo fondamentale. Il principio di relativit` a einsteiniana, che afferma che tutte le leggi della fisica devono avere la stessa forma in tutti i sistemi di riferimento inerziali, è emerso con forza da questa teoria ed è andato consolidandosi sempre di più, man mano che le nostre conoscenze del mondo microscopico sono diventate più complete: tutte le interazioni fondamentali rispettano infatti tale principio. Il modo più semplice ed elegante per implementarlo — difatti l'unico di un'utilità concreta — è rappresentato dal paradigma della covarianza a vista nell'ambito del calcolo tensoriale. Questo paradigma è stato applicato con successo a tutte le teorie di carattere fondamentale, come le teorie che descrivono le quattro interazioni fondamentali e le più speculative teorie di superstringa, e mantiene la sua piena efficacia anche in teoria quantistica. La nostra esposizione dell'Elettrodinamica classica si baserà dunque a ragione su questo paradigma.

  1. Towards a Collective Intelligence: Transmediality and the Wu Ming Project

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    Melina Anne Masterson

    2014-11-01

    Full Text Available Dagli albori della Seconda Repubblica in Italia,  le strategie di dominio sui mass media dell’ex premier Silvio Berlusconi hanno avuto un effetto considerevole sull’immaginario culturale italiano. In un approccio multisensoriale e multimediale alla scrittura, il collettivo Wu Ming mette in questione i paradigmi culturali che negli ultimi venti anni sono diventati egemonici. L’esperienza di un romanzo dei Wu Ming va ben oltre la parola stampata poiché cerca di stimolare tutti i cinque sensi per arricchire il modo in cui il lettore vive quello che c’è sulla pagina, dimostrando esempi chiari della «convergence culture» coniata da Henry Jenkins. Questo saggio esamina l’interazione tra parola e immagine messa in atto dal collettivo tramite il sito Pinterest e illustra come questo aspetto del loro progetto rappresenti un microcosmo di un approccio complessivo alla creazione estetica e alla pratica culturale. Inoltre, questo saggio descrive in che modo il processo collettivo di consumo portato avanti dai Wu Ming contribuisca alla formazione delle «communities of sentiment» di Arjun Appadurai e alla «intelligenza collettiva» di Jenkins. Queste sono formazioni che rivitalizzano il concetto di cultura popolare per la nostra epoca digitale e offrono un’alternativa ad un immaginario culturale italiano sovra-determinato dalle pratiche del Berlusconismo.

  2. Mafia, psychopathology and psychotherapy: insights from a research

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    Cecilia Giordano

    2013-06-01

    Full Text Available The article discusses the issues related to psychotherapeutic work with people belonging to mafia families from a reasearch of a sample of psychotherapists of the three regions in which the criminal organization is historically strong and deeply rooted (Sicily, Campania, Calabria.After the massacres of '92, in fact, the entire organization Cosa Nostra is in a state of crisis. From those years, the mental suffering of these people began to leak out of these realities through an explicit request for help to the psychotherapists working in mental health services or private.What does really mean for a therapist helping a patient to reveal their history deeply marked by murder, betrayal, white deads and men known to the judicial reporting?In this sense, this current contribution aims to highlight, through the analysis of counter transference dynamics which are activated in the therapist, the pecularities and difficulties characterizing the relationship in the clinical work with people belonging to mafia families.

  3. L’educatore sociale fra i Servizi e l’intervento di strada.

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    Chiara Giustini

    2007-07-01

    Full Text Available Ci siamo sempre poste molte domande sulla povertà, sulle cause dell'impoverimento, sulle responsabilità di noi “ricchi”, sulle possibilità che ogni persona ha di cambiare le cose. Forse è per questo che tre anni fa abbiamo deciso di aderire alla proposta del prof. Genovese e di partecipare al progetto "Un sacco a pelo per l'inverno" promosso dalla Caritas Diocesana di Bologna: da questa collaborazione è nato il Gruppo Nuove Povertà, tuttora impegnato in attività di ricerca sulla povertà, di impegno concreto e di sensibilizzazione al tema della marginalità nella nostra città e di formazione per gli studenti della Facoltà di Scienze della Formazione. Forse è sempre per questo che per le nostre tesi abbiamo affrontato il problema della povertà e delle nuove povertà, la condizione dei senza dimora e le risposte dei Servizi. Ne sono nati due articoli: il primo, firmato da Federica Filippini, affronta il tema della povertà nella sua multidimensionalità e analizza in particolare la condizione dei senza dimora, il percorso di impoverimento, le difficoltà della vita in strada, il rapporto con la città e i Servizi; il secondo, firmato da Chiara Giustini, si sofferma, invece, sulla figura dell'educatore, sia all'interno dei Servizi rivolti ai senza dimora, sia nel lavoro di strada.

  4. Comparative Assessment of Mediterranean Gorgonian-Associated Microbial Communities Reveals Conserved Core and Locally Variant Bacteria

    KAUST Repository

    van de Water, Jeroen A J M

    2016-10-10

    Gorgonians are key habitat-forming species of Mediterranean benthic communities, but their populations have suffered from mass mortality events linked to high summer seawater temperatures and microbial disease. However, our knowledge on the diversity, dynamics and function of gorgonian-associated microbial communities is limited. Here, we analysed the spatial variability of the microbiomes of five sympatric gorgonian species (Eunicella singularis, Eunicella cavolini, Eunicella verrucosa, Leptogorgia sarmentosa and Paramuricea clavata), collected from the Mediterranean Sea over a scale of ∼1100 km, using next-generation amplicon sequencing of the 16S rRNA gene. The microbiomes of all gorgonian species were generally dominated by members of the genus Endozoicomonas, which were at very low abundance in the surrounding seawater. Although the composition of the core microbiome (operational taxonomic units consistently present in a species) was found to be unique for each host species, significant overlap was observed. These spatially consistent associations between gorgonians and their core bacteria suggest intricate symbiotic relationships and regulation of the microbiome composition by the host. At the same time, local variations in microbiome composition were observed. Functional predictive profiling indicated that these differences could be attributed to seawater pollution. Taken together, our data indicate that gorgonian-associated microbiomes are composed of spatially conserved bacteria (core microbiome members) and locally variant members, and that local pollution may influence these local associations, potentially impacting gorgonian health.

  5. Nitrogen Fixation Aligns with nifH Abundance and Expression in Two Coral Trophic Functional Groups

    KAUST Repository

    Pogoreutz, Claudia

    2017-06-28

    Microbial nitrogen fixation (diazotrophy) is a functional trait widely associated with tropical reef-building (scleractinian) corals. While the integral role of nitrogen fixation in coral nutrient dynamics is recognized, its ecological significance across different coral functional groups remains yet to be evaluated. Here we set out to compare molecular and physiological patterns of diazotrophy (i.e., nifH gene abundance and expression as well as nitrogen fixation rates) in two coral families with contrasting trophic strategies: highly heterotrophic, free-living members of the family Fungiidae (Pleuractis granulosa, Ctenactis echinata), and mostly autotrophic coral holobionts with low heterotrophic capacity (Pocilloporidae: Pocillopora verrucosa, Stylophora pistillata). The Fungiidae exhibited low diazotroph abundance (based on nifH gene copy numbers) and activity (based on nifH gene expression and the absence of detectable nitrogen fixation rates). In contrast, the mostly autotrophic Pocilloporidae exhibited nifH gene copy numbers and gene expression two orders of magnitude higher than in the Fungiidae, which coincided with detectable nitrogen fixation activity. Based on these data, we suggest that nitrogen fixation compensates for the low heterotrophic nitrogen uptake in autotrophic corals. Consequently, the ecological importance of diazotrophy in coral holobionts may be determined by the trophic functional group of the host.

  6. {delta}{sup 13}C and {delta}{sup 15}N shifts in benthic invertebrates exposed to sewage from McMurdo Station, Antarctica

    Energy Technology Data Exchange (ETDEWEB)

    Conlan, Kathleen E. [Canadian Musem of Nature, P.O. Box 3443 Station D, Ottawa, Ont., K1P 6P4 (Canada)]. E-mail kconlan@mus-nature.ca; Rau, Greg H. [Institute of Marine Sciences, University of California, Santa Cruz, CA 95064 (United States); Kvitek, Rikk G. [Earth Systems Science and Policy, California State University Monterey Bay, 100 Campus Center, Seaside, CA 93955 (United States)

    2006-12-15

    In an effort to identify biomonitors for contamination of Antarctic marine benthos by sewage, this study determines whether the US Antarctic Program's McMurdo Station produces a benthic sewage footprint and whether resident megafauna are assimilating sewage-derived material. We identified strong C and N isotopic gradients in benthic sediment as a function of downstream distance from McMurdo Station's point-source sewage addition. Sediment C and N isotope ratios approached marine background levels at the sampling end-point 612 m downcurrent. Based on isotope abundances in their tissues, at least some sewage C and N were assimilated by the sedentary, suspension feeding soft coral Alcyonium antarcticum, ascidian Cnemidocarpa verrucosa and bivalve Laternula elliptica. However, as inferred by tissue-sediment differences in downstream isotope trends, such assimilation was not in proportion to sewage exposure and input, therefore implying non-generalist feeding behavior by these species. In contrast, the motile, generalist feeding sea urchin Sterechinus neumayeri, sea star Odontaster validus and ribbon worm Parborlasia corrugatus showed isotopic evidence of sewage C and N assimilation roughly in proportion to sewage input. We recommend these generalist feeders for further use as biomonitors at this site now that sewage treatment has been implemented. As these species are circumpolar in distribution, they may also prove useful elsewhere in the Antarctic.

  7. δ13C and δ15N shifts in benthic invertebrates exposed to sewage from McMurdo Station, Antarctica

    International Nuclear Information System (INIS)

    Conlan, Kathleen E. . E-mail kconlan@mus-nature.ca; Rau, Greg H.; Kvitek, Rikk G.

    2006-01-01

    In an effort to identify biomonitors for contamination of Antarctic marine benthos by sewage, this study determines whether the US Antarctic Program's McMurdo Station produces a benthic sewage footprint and whether resident megafauna are assimilating sewage-derived material. We identified strong C and N isotopic gradients in benthic sediment as a function of downstream distance from McMurdo Station's point-source sewage addition. Sediment C and N isotope ratios approached marine background levels at the sampling end-point 612 m downcurrent. Based on isotope abundances in their tissues, at least some sewage C and N were assimilated by the sedentary, suspension feeding soft coral Alcyonium antarcticum, ascidian Cnemidocarpa verrucosa and bivalve Laternula elliptica. However, as inferred by tissue-sediment differences in downstream isotope trends, such assimilation was not in proportion to sewage exposure and input, therefore implying non-generalist feeding behavior by these species. In contrast, the motile, generalist feeding sea urchin Sterechinus neumayeri, sea star Odontaster validus and ribbon worm Parborlasia corrugatus showed isotopic evidence of sewage C and N assimilation roughly in proportion to sewage input. We recommend these generalist feeders for further use as biomonitors at this site now that sewage treatment has been implemented. As these species are circumpolar in distribution, they may also prove useful elsewhere in the Antarctic

  8. Seasonal Stability in the Microbiomes of Temperate Gorgonians and the Red Coral Corallium rubrum Across the Mediterranean Sea.

    Science.gov (United States)

    van de Water, Jeroen A J M; Voolstra, Christian R; Rottier, Cecile; Cocito, Silvia; Peirano, Andrea; Allemand, Denis; Ferrier-Pagès, Christine

    2018-01-01

    Populations of key benthic habitat-forming octocoral species have declined significantly in the Mediterranean Sea due to mass mortality events caused by microbial disease outbreaks linked to high summer seawater temperatures. Recently, we showed that the microbial communities of these octocorals are relatively structured; however, our knowledge on the seasonal dynamics of these microbiomes is still limited. To investigate their seasonal stability, we collected four soft gorgonian species (Eunicella singularis, Eunicella cavolini, Eunicella verrucosa and Leptogorgia sarmentosa) and the precious red coral (Corallium rubrum) from two coastal locations with different terrestrial impact levels in the Mediterranean Sea, and used next-generation amplicon sequencing of the 16S rRNA gene. The microbiomes of all soft gorgonian species were dominated by the same 'core microbiome' bacteria belonging to the Endozoicomonas and the Cellvibrionales clade BD1-7, whereas the red coral microbiome was primarily composed of 'core' Spirochaetes, Oceanospirillales ME2 and Parcubacteria. The associations with these bacterial taxa were relatively consistent over time at each location for each octocoral species. However, differences in microbiome composition and seasonal dynamics were observed between locations and could primarily be attributed to locally variant bacteria. Overall, our data provide further evidence of the intricate symbiotic relationships that exist between Mediterranean octocorals and their associated microbes, which are ancient and highly conserved over both space and time, and suggest regulation of the microbiome composition by the host, depending on local conditions.

  9. The diversity and distribution of Holothuroidea in shallow waters of Baluran National Park, Indonesia

    Directory of Open Access Journals (Sweden)

    ARIF MOHAMMAD SIDDIQ

    2016-04-01

    Full Text Available Abstract. Siddiq AM, Atmowidi T, Qayim I. 2015. The diversity and distribution of Holothuroidea in shallow waters of Baluran National Park, Indonesia. Biodiversitas 17: 55-60. A study of the diversity and distribution of sea cucumber (Holothuroidea in shallow waters at Baluran National Park, East Java, Indonesia was carried out from July until September 2015. The method used in this study was systematic transect in low tide condition. Samples were collected by hands at intertidal sites. Identification of sea cucumber species based on morphological ossicles. Twenty one species of Holothuroidea belonging two orders and four families were found in this study. The most dominant family found was Holothuriidae (16 species, followed by Stichopodidae (2 species, Synaptidae (2 species, and Chiridotidae (1 spesies. Four species (Holothuria olivacea, H. verrucosa, Labidodemas rugosum, and Chiridota smirnovi are new record for Java waters and one species (H. papillifera is a new record for Indonesian waters. Two morphospecies (H. aff. macroperona and Stichopus cf. monotuberculatus need reconfirmation to species level. The highest abundance species of Holothuroidea was found at under rock with 15 species. Whereas, the highest number of individuals was found in seagrass areas with 5457 individuals. H. atra has extensive habitat distribution, such as seagrass, macroalgae, coral reef, dead coral, sand, and under rock.

  10. Sessile macro-epibiotic community of solitary ascidians, ecosystem engineers in soft substrates of Potter Cove, Antarctica

    Directory of Open Access Journals (Sweden)

    Clara Rimondino

    2015-01-01

    Full Text Available The muddy bottoms of inner Potter Cove, King George Island (Isla 25 de Mayo, South Shetlands, Antarctica, show a high density and richness of macrobenthic species, particularly ascidians. In other areas, ascidians have been reported to play the role of ecosystem engineers, as they support a significant number of epibionts, increasing benthic diversity. In this study, a total of 21 sessile macro-epibiotic taxa present on the ascidian species Corella antarctica Sluiter, 1905, Cnemidocarpa verrucosa (Lesson, 1830 and Molgula pedunculata Herdman, 1881 were identified, with Bryozoa being the most diverse. There were differences between the three ascidian species in terms of richness, percent cover and diversity of sessile macro-epibionts. The morphological characteristics of the tunic surface, the available area for colonization (and its relation with the age of the basibiont individuals and the pH of the ascidian tunic seem to explain the observed differences. Recent environmental changes in the study area (increase of suspended particulate matter caused by glaciers retreat have been related to observed shifts in the benthic community structure, negatively affecting the abundance and distribution of the studied ascidian species. Considering the diversity of sessile macro-epibionts found on these species, the impact of environmental shifts may be greater than that estimated so far.

  11. Delta13C and delta15N shifts in benthic invertebrates exposed to sewage from McMurdo Station, Antarctica.

    Science.gov (United States)

    Conlan, Kathleen E; Rau, Greg H; Kvitek, Rikk G

    2006-12-01

    In an effort to identify biomonitors for contamination of Antarctic marine benthos by sewage, this study determines whether the US Antarctic Program's McMurdo Station produces a benthic sewage footprint and whether resident megafauna are assimilating sewage-derived material. We identified strong C and N isotopic gradients in benthic sediment as a function of downstream distance from McMurdo Station's point-source sewage addition. Sediment C and N isotope ratios approached marine background levels at the sampling end-point 612 m downcurrent. Based on isotope abundances in their tissues, at least some sewage C and N were assimilated by the sedentary, suspension feeding soft coral Alcyonium antarcticum, ascidian Cnemidocarpa verrucosa and bivalve Laternula elliptica. However, as inferred by tissue-sediment differences in downstream isotope trends, such assimilation was not in proportion to sewage exposure and input, therefore implying non-generalist feeding behavior by these species. In contrast, the motile, generalist feeding sea urchin Sterechinus neumayeri, sea star Odontaster validus and ribbon worm Parborlasia corrugatus showed isotopic evidence of sewage C and N assimilation roughly in proportion to sewage input. We recommend these generalist feeders for further use as biomonitors at this site now that sewage treatment has been implemented. As these species are circumpolar in distribution, they may also prove useful elsewhere in the Antarctic.

  12. Seasonal Stability in the Microbiomes of Temperate Gorgonians and the Red Coral Corallium rubrum Across the Mediterranean Sea

    KAUST Repository

    van de Water, Jeroen A. J. M.

    2017-07-05

    Populations of key benthic habitat-forming octocoral species have declined significantly in the Mediterranean Sea due to mass mortality events caused by microbial disease outbreaks linked to high summer seawater temperatures. Recently, we showed that the microbial communities of these octocorals are relatively structured; however, our knowledge on the seasonal dynamics of these microbiomes is still limited. To investigate their seasonal stability, we collected four soft gorgonian species (Eunicella singularis, Eunicella cavolini, Eunicella verrucosa and Leptogorgia sarmentosa) and the precious red coral (Corallium rubrum) from two coastal locations with different terrestrial impact levels in the Mediterranean Sea, and used next-generation amplicon sequencing of the 16S rRNA gene. The microbiomes of all soft gorgonian species were dominated by the same \\'core microbiome\\' bacteria belonging to the Endozoicomonas and the Cellvibrionales clade BD1-7, whereas the red coral microbiome was primarily composed of \\'core\\' Spirochaetes, Oceanospirillales ME2 and Parcubacteria. The associations with these bacterial taxa were relatively consistent over time at each location for each octocoral species. However, differences in microbiome composition and seasonal dynamics were observed between locations and could primarily be attributed to locally variant bacteria. Overall, our data provide further evidence of the intricate symbiotic relationships that exist between Mediterranean octocorals and their associated microbes, which are ancient and highly conserved over both space and time, and suggest regulation of the microbiome composition by the host, depending on local conditions.

  13. Nitrogen Fixation Aligns with nifH Abundance and Expression in Two Coral Trophic Functional Groups

    KAUST Repository

    Pogoreutz, Claudia; Radecker, Nils; Cardenas, Anny; Gä rdes, Astrid; Wild, Christian; Voolstra, Christian R.

    2017-01-01

    Microbial nitrogen fixation (diazotrophy) is a functional trait widely associated with tropical reef-building (scleractinian) corals. While the integral role of nitrogen fixation in coral nutrient dynamics is recognized, its ecological significance across different coral functional groups remains yet to be evaluated. Here we set out to compare molecular and physiological patterns of diazotrophy (i.e., nifH gene abundance and expression as well as nitrogen fixation rates) in two coral families with contrasting trophic strategies: highly heterotrophic, free-living members of the family Fungiidae (Pleuractis granulosa, Ctenactis echinata), and mostly autotrophic coral holobionts with low heterotrophic capacity (Pocilloporidae: Pocillopora verrucosa, Stylophora pistillata). The Fungiidae exhibited low diazotroph abundance (based on nifH gene copy numbers) and activity (based on nifH gene expression and the absence of detectable nitrogen fixation rates). In contrast, the mostly autotrophic Pocilloporidae exhibited nifH gene copy numbers and gene expression two orders of magnitude higher than in the Fungiidae, which coincided with detectable nitrogen fixation activity. Based on these data, we suggest that nitrogen fixation compensates for the low heterotrophic nitrogen uptake in autotrophic corals. Consequently, the ecological importance of diazotrophy in coral holobionts may be determined by the trophic functional group of the host.

  14. Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes.

    Science.gov (United States)

    Jung, Hyun Ah; Kim, Jae-I; Choung, Se Young; Choi, Jae Sue

    2014-08-01

    As part of our efforts to isolate anti-hepatotoxic agents from marine natural products, we screened the ability of 14 edible varieties of Korean seaweed to protect against doxorubicin-induced hepatotoxicity in primary rat hepatocytes. Among the crude extracts of two Chlorophyta (Codium fragile and Capsosiphon fulvescens), seven Phaeophyta (Undaria pinnatifida, Sargassum thunbergii, Pelvetia siliquosa, Ishige okamurae, Ecklonia cava, Ecklonia stolonifera and Eisenia bicyclis), five Rhodophyta (Chondrus ocellatus, Gelidium amansii, Gracilaria verrucosa, Symphycladia latiuscula and Porphyra tenera), and the extracts of Ecklonia stolonifera, Ecklonia cava, Eisenia bicyclis and Pelvetia siliquosa exhibited significant protective effects on doxorubicin-induced hepatotoxicity, with half maximal effective concentration (EC50) values of 2.0, 2.5, 3.0 and 15.0 μg/ml, respectively. Since Ecklonia stolonifera exhibits a significant protective potential and is frequently used as foodstuff, we isolated six phlorotannins, including phloroglucinol (1), dioxinodehydroeckol (2), eckol (3), phlorofucofuroeckol A (4), dieckol (5) and triphloroethol-A (6). Phlorotannins 2 ∼ 6 exhibited potential protective effects on doxorubicin-induced hepatotoxicity, with corresponding EC50 values of 3.4, 8.3, 4.4, 5.5 and 11.5 μg/ml, respectively. The results clearly demonstrated that the anti-hepatotoxic effects of Ecklonia stolonifera and its isolated phlorotannins are useful for further exploration and development of therapeutic modalities for treatment of hepatotoxicity. © 2014 Royal Pharmaceutical Society.

  15. Extensive phenotypic plasticity of a Red Sea coral over a strong latitudinal temperature gradient suggests limited acclimatization potential to warming

    KAUST Repository

    Sawall, Yvonne

    2015-03-10

    Global warming was reported to cause growth reductions in tropical shallow water corals in both, cooler and warmer, regions of the coral species range. This suggests regional adaptation with less heat-tolerant populations in cooler and more thermo-tolerant populations in warmer regions. Here, we investigated seasonal changes in the in situ metabolic performance of the widely distributed hermatypic coral Pocillopora verrucosa along 12° latitudes featuring a steep temperature gradient between the northern (28.5°N, 21-27°C) and southern (16.5°N, 28-33°C) reaches of the Red Sea. Surprisingly, we found little indication for regional adaptation, but strong indications for high phenotypic plasticity: Calcification rates in two seasons (winter, summer) were found to be highest at 28-29°C throughout all populations independent of their geographic location. Mucus release increased with temperature and nutrient supply, both being highest in the south. Genetic characterization of the coral host revealed low inter-regional variation and differences in the Symbiodinium clade composition only at the most northern and most southern region. This suggests variable acclimatization potential to ocean warming of coral populations across the Red Sea: high acclimatization potential in northern populations, but limited ability to cope with ocean warming in southern populations already existing at the upper thermal margin for corals.

  16. Explained and unexplained tissue loss in corals from the Tropical Eastern Pacific

    Science.gov (United States)

    Rodriguez-Villalobos, Jenny Carolina; Work, Thierry M.; Calderon-Aguilera, Luis Eduardo; Reyes-Bonilla, Hector; Hernández, Luis

    2015-01-01

    Coral reefs rival rainforest in biodiversity, but are declining in part because of disease. Tissue loss lesions, a manifestation of disease, are present in dominant Pocillopora along the Pacific coast of Mexico. We characterized tissue loss in 7 species of Pocillopora from 9 locations (44 sites) spanning southern to northern Mexico. Corals were identified to species, and tissue loss lesions were photographed and classified as those explainable by predation and those that were unexplained. A focal predation study was done concurrently at 3 locations to confirm origin of explained lesions. Of 1054 cases of tissue loss in 7 species of corals, 84% were associated with predation (fish, snails, or seastar) and the remainder were unexplained. Types of tissue loss were not related to coral density; however there was significant geographic heterogeneity in type of lesion; one site in particular (Cabo Pulmo) had the highest prevalence of predator-induced tissue loss (mainly pufferfish predation). Crown-of-thorns starfish, pufferfish, and snails were the most common predators and preferred P. verrucosa, P. meandrina, and P. capitata, respectively. Of the 9 locations, 4 had unexplained tissue loss with prevalence ranging from 1 to 3% with no species predilection. Unexplained tissue loss was similar to white syndrome (WS) in morphology, indicating additional study is necessary to clarify the cause(s) of the lesions and the potential impacts to dominant corals along the Pacific coast of Mexico.

  17. Phylogenetic overview of the genus Genea (Pezizales, Ascomycota) with an emphasis on European taxa.

    Science.gov (United States)

    Alvarado, Pablo; Cabero, Julio; Moreno, Gabriel; Bratek, Zoltán; van Vooren, Nicolas; Kaounas, Vasileios; Konstantinidis, Giorgos; Agnello, Carlo; Merényi, Zsolt; Smith, Matthew E; Vizzini, Alfredo; Trappe, James M

    2016-01-01

    We constructed a comprehensive phylogeny of the genus Genea, with new molecular data from samples collected in several countries in temperate and Mediterranean Europe, as well as North America. Type specimens and authentic material of most species were examined to support identifications. The molecular identity of the most common species in Genea was compared with nuc rDNA internal transcribed spacer (ITS), D1-D2 domains of 28S nuc rDNA (28S rDNA) and translation elongation factor 1-α ene (TEF1) profiles of 10 recently proposed taxa, G. brunneocarpa, G. compressa, G. dentata, G. fageticola, G. lobulata, G. oxygala, G. pinicola, G. pseudobalsleyi, G. pseudoverrucosa and G. tuberculata, supporting their status as distinct species. Genea mexicana and G. thaxteri on the one hand and G. sphaerica and G. lespiaultii on the other are closely related. Multiple lineages were recorded for G. verrucosa and G. fragrans, but we found no morphological traits to discriminate among them, so we tentatively interpreted them as cryptic species. A key to species of the genus Genea is provided to facilitate identification. We provide macroscopic images of fresh specimens and of representative spores of most species. Finally, we conducted a molecular analysis of the divergence time for Genea and discuss the implications of our results. © 2016 by The Mycological Society of America.

  18. Characteristic of Tuber spp. localities in natural stands with emphasis on plant species composition

    Directory of Open Access Journals (Sweden)

    Dorota Hilszczanska

    2014-12-01

    Full Text Available Fungi belonging to the genus Tuber establish ectomycorrhizal symbioses with shrubs, trees and some herbaceous plants. Some Tuber species, for example, T. melanosporum, T. magnatum, T. aestivum are economically important because they produce edible fruiting bodies with a distinctive taste and flavor. Our concept of truffle ecophysiology is dominated by the symbiosis with deciduous hosts, such as: Quercus spp., Fagus sylvatica, Castanea sativa, Corylus spp., Carpinus betulus, Ostrya carpinifolia, Betula verrucosa, and Tilia spp., whereas the real range of hosts in nature seems to be much wider. Moreover, interactions between Tuber mycelium and plant community could be more complex than just forming the ectomycorrhizal symbiosis. Here we show our inventory of plants and soils at six truffle’ sites in the southern part of Poland (Nida Basin and Przedbórz Upland. The aim of this study was to widen our understanding of ecological factors affecting Tuber spp., in the context of pioneering stage of research on truffles in Poland. We hope our findings will have a practical application and will help to choose suitable soils for truffle orchards.

  19. Efeito de diferentes isolados fúngicos da mesma comunidade micorrízica no crescimento e absorção de fósforo em soja e trevo vermelho Effect of different fungal isolates from the same mycorrhizal community on plant growth and phosphorus uptake in soybean and red clover

    Directory of Open Access Journals (Sweden)

    S. L. Stürmer

    2004-08-01

    Full Text Available Experimentos que testam a eficiência de fungos micorrízicos arbusculares (FMAs provenientes de uma mesma amostra de solo complementam os estudos de diversidade taxonômica por promover relações funcionais dentro das comunidades micorrízicas. Neste estudo, isolados fúngicos de três comunidades distintas foram avaliados quanto a sua eficiência em aumentar a produção de biomassa e teor de P em dois hospedeiros micotróficos. No primeiro experimento, avaliou-se o efeito de 13 isolados de FMA pertencentes às comunidades JA205, MN414 e VA105, para testar a hipótese de que pelo menos um isolado de cada comunidade micorrízica seria eficiente para a soja. Todos os três isolados da comunidade JA205 e Glomus clarum da comunidade VA105 aumentaram a produção de biomassa seca em relação às plantas não micorrizadas. Os isolados da comunidade MN414 não influíram na produção de biomassa seca. A concentração de P, no entanto, foi significativamente aumentada por 7 dos 13 isolados em relação às plantas-controle. No segundo experimento, avaliou-se o efeito da inoculação separada e da co-inoculação de isolados das comunidades VA105 e MN414 em trevo. A colonização pelos cinco isolados de ambas as comunidades aumentou significativamente a produção de biomassa seca e conteúdo de P no trevo, com exceção de Scutellospora calospora MN414C que teve efeito apenas no conteúdo de P. A co-inoculação de isolados nem sempre produziu maior benefício do que a inoculação com isolados em separado. Plantas colonizadas com S. verrucosa VA105B + Glomus clarum VA105D produziram quantidade significativamente maior de biomassa do que plantas inoculadas com S. verrucosa apenas, mas não diferiram daquelas inoculadas com G. clarum. No outro extremo, a produção de biomassa seca e conteúdo de P não foram significativamente diferentes em plantas inoculadas com Glomus sp. MN414B + Gigaspora gigantea MN414D daquelas inoculadas com cada isolado

  20. Extensive phenotypic plasticity of a Red Sea coral over a strong latitudinal temperature gradient suggests limited acclimatization potential to warming

    KAUST Repository

    Sawall, Yvonne; Al-Sofyani, Abdulmoshin; Hohn, Sö nke; Banguera Hinestroza, Eulalia; Voolstra, Christian R.; Wahl, Martin

    2015-01-01

    Global warming was reported to cause growth reductions in tropical shallow water corals in both, cooler and warmer, regions of the coral species range. This suggests regional adaptation with less heat-tolerant populations in cooler and more thermo-tolerant populations in warmer regions. Here, we investigated seasonal changes in the in situ metabolic performance of the widely distributed hermatypic coral Pocillopora verrucosa along 12° latitudes featuring a steep temperature gradient between the northern (28.5°N, 21-27°C) and southern (16.5°N, 28-33°C) reaches of the Red Sea. Surprisingly, we found little indication for regional adaptation, but strong indications for high phenotypic plasticity: Calcification rates in two seasons (winter, summer) were found to be highest at 28-29°C throughout all populations independent of their geographic location. Mucus release increased with temperature and nutrient supply, both being highest in the south. Genetic characterization of the coral host revealed low inter-regional variation and differences in the Symbiodinium clade composition only at the most northern and most southern region. This suggests variable acclimatization potential to ocean warming of coral populations across the Red Sea: high acclimatization potential in northern populations, but limited ability to cope with ocean warming in southern populations already existing at the upper thermal margin for corals.

  1. Acantosis Nigricans Maligna Acanthosis Nigricans Maligna

    Directory of Open Access Journals (Sweden)

    C Vallejo

    2011-06-01

    Full Text Available Es un síndrome paraneoplásico poco común, que se asocia a tumores gastrointestinales, más frecuentemente a adenocarcinoma gástrico (69%. Afecta a ambos sexos y no tiene prevalencia por grupo étnico alguno. Clínicamente son lesiones hiperpigmentadas, hipertróficas y verrucosas en zonas de flexión y en la mayoría de los casos, las mucosas también resultan afectadas con lesiones papilomatosas. Habitualmente desaparecen con la eliminación del tumor o reaparecen con la recurrencia o metástasis.Acanthosis nigricans malignant is an uncommon paraneoplastic syndrome associated with gastrointestinal tumors, frequently gastric adenocarcinoma, affects both sexes and it has not prevalence by race. Clinically, lesions are hyperpigmented, hypertrophic and verrucous in flexion areas and in most cases the mucous membranes are also affected with papillomatous lesions. Tipically disappears with the removal of the tumor and reappears when recurrence or metastasis occur.

  2. ELECTROCHEMICAL FINGERPRINT STUDIES OF SELECTED MEDICINAL PLANTS RICH IN FLAVONOIDS.

    Science.gov (United States)

    Konieczyński, Paweł

    2015-01-01

    The combination of a size-exclusion column (SEC) with electrochemical (voltammetric) detection at a boron-doped diamond electrode (BDDE) was applied for studying the correlations between electroactive Cu and Fe species with phenolic groups of flavonoids. For comparison with electrochemical results, SEC-HPLC-DAD detection was used. The studied plant material comprised of: Betula verrucosa Ehrh., Equisetun arvense L., Polygonum aviculare L., Viola tricolor L., Crataegus oxyacantha L., Sambucus nigra L. and Helichrysum arenarium (L.) Moench. Based upon the results, high negative correlation was found for the chromatographic peak currents at 45 min with the sum of Cu and Fe for the aqueous extracts of Sambucus, Crataegus and Betula species, and for the peak currents at 65 min of the aqueous extracts of Sambucus, Crataegus, Helichrysum and Betula botanical species. This behavior confirms that it is mainly the flavonoids with easily oxidizable phenolic groups which are strongly influenced by the presence of Cu and Fe. Moreover, the electrochemical profiles obtained thanks to the use of HPLC hyphenated with voltammetric detection can be potentially applied for fingerprint studies of the plant materials used in medicine.

  3. Endozoicomonas genomes reveal functional adaptation and plasticity in bacterial strains symbiotically associated with diverse marine hosts

    KAUST Repository

    Neave, Matthew J.

    2017-01-17

    Endozoicomonas bacteria are globally distributed and often abundantly associated with diverse marine hosts including reef-building corals, yet their function remains unknown. In this study we generated novel Endozoicomonas genomes from single cells and metagenomes obtained directly from the corals Stylophora pistillata, Pocillopora verrucosa, and Acropora humilis. We then compared these culture-independent genomes to existing genomes of bacterial isolates acquired from a sponge, sea slug, and coral to examine the functional landscape of this enigmatic genus. Sequencing and analysis of single cells and metagenomes resulted in four novel genomes with 60–76% and 81–90% genome completeness, respectively. These data also confirmed that Endozoicomonas genomes are large and are not streamlined for an obligate endosymbiotic lifestyle, implying that they have free-living stages. All genomes show an enrichment of genes associated with carbon sugar transport and utilization and protein secretion, potentially indicating that Endozoicomonas contribute to the cycling of carbohydrates and the provision of proteins to their respective hosts. Importantly, besides these commonalities, the genomes showed evidence for differential functional specificity and diversification, including genes for the production of amino acids. Given this metabolic diversity of Endozoicomonas we propose that different genotypes play disparate roles and have diversified in concert with their hosts.

  4. Diversity of MAPs in some plant communities of Stara Planina

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    Obratov-Petković Dragica

    2006-01-01

    Full Text Available The high floristic diversity of Stara Planina was the starting base for the research of medicinal and aromatic plants (MAPs in individual forest and meadow communities. The sites Javor and Prelesje, forest community Fagetum moesiacae montanum B. Jov. 1953, pioneer community of birch Betuletum verrucosae s.l. and meadow community Agrostietum vulgaris (capillaris Pavlović, Z. 1955, were researched as follows: soil types, floristic composition and structure of the community, percentage of MAPs, as well as the selection of species which, according to the predetermined criteria can be recommended for further exploitation. The study shows that the soil of the forest communities is eutric brown, and meadow soils are dystric and eutric humus-siliceous. The percentage of MAPs in the floristic structure of the study sites in forest and meadow communities is 32.35%. The following species can be recommended for the collection and utilisation: Hypericum perforatum L., Asperula odorata L., Dryopteris filix-mas (L Schott. Urtica dioica L., Euphorbia amygdaloides L., Prunella grandiflora L. Tanacetum vulgare L., Achillea millefolium L., Rumex acetosa L., Campanula glomerata L., Stachys officinalis (L Trevis., Plantago lanceolata W. et K., Potentilla erecta (L Rauchel, Chamaespartium sagittale (L P. Gibbs. Cynanchum vincetoxicum (L Pers., Euphrasia stricta Host., Fagus moesiaca (Matt Liebl. and Fragaria vesca L.

  5. Phytometabolite Dehydroleucodine Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Human Astrocytoma Cells through p73/p53 Regulation.

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    Natalia Bailon-Moscoso

    Full Text Available Accumulating evidence supports the idea that secondary metabolites obtained from medicinal plants (phytometabolites may be important contributors in the development of new chemotherapeutic agents to reduce the occurrence or recurrence of cancer. Our study focused on Dehydroleucodine (DhL, a sesquiterpene found in the provinces of Loja and Zamora-Chinchipe. In this study, we showed that DhL displayed cytostatic and cytotoxic activities on the human cerebral astrocytoma D384 cell line. With lactone isolated from Gynoxys verrucosa Wedd, a medicinal plant from Ecuador, we found that DhL induced cell death in D384 cells by triggering cell cycle arrest and inducing apoptosis and DNA damage. We further found that the cell death resulted in the increased expression of CDKN1A and BAX proteins. A marked induction of the levels of total TP73 and phosphorylated TP53, TP73, and γ-H2AX proteins was observed in D384 cells exposed to DhL, but no increase in total TP53 levels was detected. Overall these studies demonstrated the marked effect of DhL on the diminished survival of human astrocytoma cells through the induced expression of TP73 and phosphorylation of TP73 and TP53, suggesting their key roles in the tumor cell response to DhL treatment.

  6. Phytometabolite Dehydroleucodine Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Human Astrocytoma Cells through p73/p53 Regulation.

    Science.gov (United States)

    Bailon-Moscoso, Natalia; González-Arévalo, Gabriela; Velásquez-Rojas, Gabriela; Malagon, Omar; Vidari, Giovanni; Zentella-Dehesa, Alejandro; Ratovitski, Edward A; Ostrosky-Wegman, Patricia

    2015-01-01

    Accumulating evidence supports the idea that secondary metabolites obtained from medicinal plants (phytometabolites) may be important contributors in the development of new chemotherapeutic agents to reduce the occurrence or recurrence of cancer. Our study focused on Dehydroleucodine (DhL), a sesquiterpene found in the provinces of Loja and Zamora-Chinchipe. In this study, we showed that DhL displayed cytostatic and cytotoxic activities on the human cerebral astrocytoma D384 cell line. With lactone isolated from Gynoxys verrucosa Wedd, a medicinal plant from Ecuador, we found that DhL induced cell death in D384 cells by triggering cell cycle arrest and inducing apoptosis and DNA damage. We further found that the cell death resulted in the increased expression of CDKN1A and BAX proteins. A marked induction of the levels of total TP73 and phosphorylated TP53, TP73, and γ-H2AX proteins was observed in D384 cells exposed to DhL, but no increase in total TP53 levels was detected. Overall these studies demonstrated the marked effect of DhL on the diminished survival of human astrocytoma cells through the induced expression of TP73 and phosphorylation of TP73 and TP53, suggesting their key roles in the tumor cell response to DhL treatment.

  7. Ceratose liquenóide em um cão Lichenoid keratosis in a dog

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    Tatiana Mello de Souza

    2009-06-01

    Full Text Available A ceratose liquenóide é uma rara dermatopatia proliferativa descrita em humanos e cães. Nos cães, a doença caracteriza-se pelo aparecimento de placas hiperceratóticas bem circunscritas nas pinas e, menos freqüentemente, nas virilhas. Este artigo descreve um caso de ceratose liquenóide em um cão macho, Dobermann, de seis anos de idade, com lesões verrucosas e multifocais na face interna das orelhas e lesões alopécicas, hiperpigmentadas, levemente elevadas e descamativas nas axilas e virilhas, ambas com evolução de aproximadamente três meses. O diagnóstico foi realizado com base na associação entre os achados clínicos e histopatológicos.Lichenoid keratosis is a rare proliferative dermatopathy reported in human beings and dogs. In dogs the disease is characterized by well circumscribed hyperkeratotic plaques distributed in the skin of pinnae and, less frequently, in the inguinal region. This report describes a case of lichenoid keratosis in a six-year-old male Dobermann dog which had multifocal verrucous lesions in the internal aspect of the pinnae and slightly scaly, overpigmented alopecic lesions in the axillae and inguinal region; both lesions had a clinical course of approximately three months. The diagnosis was based on the association of the clinical and histopathological findings.

  8. Nutritional Basis of Butterflyfish Corallivory in the Red Sea

    KAUST Repository

    Masterman, Jessica

    2012-12-01

    The overall goal of this study was to elucidate the relationship between coral nutrition and the observed prey preferences exhibited by corallivorous butterflyfishes. Fifteen species of coral (thirteen hard, two soft) and stomach/hindgut contents from six species of butterflyfish were analyzed in this study, all collected from the central Saudi Arabian Red Sea. All samples were analyzed for lipid, total-nitrogen (proxy for protein), and ash (proxy for minerals and when combined with lipid data, allows for calculation of carbohydrate). Unfortunately, substantial errors were encountered in the experimental lipid data, precluding the use of this data set. Using the value of (protein/ash) as a proxy for potential nutritional quality, it was determined that Pocillopora cf. verrucosa and P. damicornis have the highest nutritional quality, while Acropora hyacinthus and Stylophora pistillata have intermediate nutritional quality, and all remaining 11 species have low nutritional quality. This suggests that the high nutritional quality of Pocillopora damicornis and Acropora hyacinthus may be the cause of the well documented predator preferences for these two species. Fish gut content samples were, on average, twice as rich in protein and half as rich in minerals as the coral tissue samples, suggesting either selective consumption of especially rich parts of the coral colony, or consumption of other food sources (facultative corallivores). In all six butterflyfish species, stomach content samples were consistently richer in protein and poorer in mineral content than the hindgut content samples; this suggests significant and measureable uptake of protein in the butterflyfish digestion process.

  9. Toxin gene determination and evolution in scorpaenoid fish.

    Science.gov (United States)

    Chuang, Po-Shun; Shiao, Jen-Chieh

    2014-09-01

    In this study, we determine the toxin genes from both cDNA and genomic DNA of four scorpaenoid fish and reconstruct their evolutionary relationship. The deduced protein sequences of the two toxin subunits in Sebastapistes strongia, Scorpaenopsis oxycephala, and Sebastiscus marmoratus are about 700 amino acid, similar to the sizes of the stonefish (Synanceia horrida, and Synanceia verrucosa) and lionfish (Pterois antennata and Pterois volitans) toxins previously published. The intron positions are highly conserved among these species, which indicate the applicability of gene finding by using genomic DNA template. The phylogenetic analysis shows that the two toxin subunits were duplicated prior to the speciation of Scorpaenoidei. The precedence of the gene duplication over speciation indicates that the toxin genes may be common to the whole family of Scorpaeniform. Furthermore, one additional toxin gene has been determined in the genomic DNA of Dendrochirus zebra. The phylogenetic analysis suggests that an additional gene duplication occurred before the speciation of the lionfish (Pteroinae) and a pseudogene may be generally present in the lineage of lionfish. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Some properties and cDNA cloning of proteinaceous toxins from two species of lionfish (Pterois antennata and Pterois volitans).

    Science.gov (United States)

    Kiriake, Aya; Shiomi, Kazuo

    2011-11-01

    Lionfish, members of the genera Pterois, Parapterois and Dendrochirus, are well known to be venomous, having venomous glandular tissues in dorsal, pelvic and anal spines. The lionfish toxins have been shown to cross-react with the stonefish toxins by neutralization tests using the commercial stonefish antivenom, although their chemical properties including structures have been little characterized. In this study, an antiserum against neoverrucotoxin, the stonefish Synanceia verrucosa toxin, was first raised in a guinea pig and used in immunoblotting and inhibition immunoblotting to confirm that two species of Pterois lionfish (P. antennata and P. volitans) contain a 75kDa protein (corresponding to the toxin subunit) cross-reacting with neoverrucotoxin. Then, the amino acid sequences of the P. antennata and P. volitans toxins were successfully determined by cDNA cloning using primers designed from the highly conserved sequences of the stonefish toxins. Notably, either α-subunits (699 amino acid residues) or β-subunits (698 amino acid residues) of the P. antennata and P. volitans toxins share as high as 99% sequence identity with each other. Furthermore, both α- and β-subunits of the lionfish toxins exhibit high sequence identity (70-80% identity) with each other and also with the β-subunits of the stonefish toxins. As reported for the stonefish toxins, the lionfish toxins also contain a B30.2/SPRY domain (comprising nearly 200 amino acid residues) in the C-terminal region of each subunit. Copyright © 2011 Elsevier Ltd. All rights reserved.

  11. Top-down and bottom-up characterization of nitrated birch pollen allergen Bet v 1a with CZE hyphenated to an Orbitrap mass spectrometer.

    Science.gov (United States)

    Gusenkov, Sergey; Stutz, Hanno

    2018-02-01

    Tyrosine (Tyr) residues of the major pollen allergen of birch Betula verrucosa, Bet v 1a, were nitrated by peroxynitrite. This modification enhances the allergenicity. Modified tyrosines were identified by analyzing intact allergen variants in combination with top-down and bottom-up approaches. Therefore, a laboratory-built sheath-liquid assisted ESI interface was applied for hyphenation of CE to an Orbitrap mass spectrometer to localize individual nitration sites. The major focus was on identification of primary nitration sites. The top-down approach unambiguously identified Tyr 5 as the most prominent modification site. Fragments from the allergen core and the C-terminal part carried up to three potential nitration sites, respectively. Thus, a bottom-up approach with tryptic digest was used as a complementary strategy which allowed for the unambiguous localization of nitration sites within the respective peptides. Nitration propensity for individual Tyr residues was addressed by comparison of MS signals of nitrated peptides relative to all cognates of homolog primary sequence. Combined data identified surface exposed Tyr 5 and Tyr 66 as major nitration sites followed by less accessible Tyr 158 whereas Tyr 81, 83 and 150 possess a lower nitration tendency and are apparently modified in variants with higher nitration levels. © 2018 The Authors. Electrophoresis published by Wiley-VCH Verlag GmbH & Co. KGaA.

  12. Endozoicomonas genomes reveal functional adaptation and plasticity in bacterial strains symbiotically associated with diverse marine hosts

    KAUST Repository

    Neave, Matthew J.; Michell, Craig; Apprill, Amy; Voolstra, Christian R.

    2017-01-01

    Endozoicomonas bacteria are globally distributed and often abundantly associated with diverse marine hosts including reef-building corals, yet their function remains unknown. In this study we generated novel Endozoicomonas genomes from single cells and metagenomes obtained directly from the corals Stylophora pistillata, Pocillopora verrucosa, and Acropora humilis. We then compared these culture-independent genomes to existing genomes of bacterial isolates acquired from a sponge, sea slug, and coral to examine the functional landscape of this enigmatic genus. Sequencing and analysis of single cells and metagenomes resulted in four novel genomes with 60–76% and 81–90% genome completeness, respectively. These data also confirmed that Endozoicomonas genomes are large and are not streamlined for an obligate endosymbiotic lifestyle, implying that they have free-living stages. All genomes show an enrichment of genes associated with carbon sugar transport and utilization and protein secretion, potentially indicating that Endozoicomonas contribute to the cycling of carbohydrates and the provision of proteins to their respective hosts. Importantly, besides these commonalities, the genomes showed evidence for differential functional specificity and diversification, including genes for the production of amino acids. Given this metabolic diversity of Endozoicomonas we propose that different genotypes play disparate roles and have diversified in concert with their hosts.

  13. Non-destructive methods for peat layer assessment in oligotrophic peat bogs: a case study from Poiana Ştampei, Romania

    Directory of Open Access Journals (Sweden)

    Iuliana F. Gheorghe

    2011-01-01

    Full Text Available Practices currently employed in the investigation and characterisation of peat deposits are destructive and may irremediable perturb peat bog development even in cases when exploitation is not carried out. We investigated the correlation between vegetation characteristics in the active area of Poiana Ştampei peat bog, Romania, and the underlying peat layer depth, aiming at establishing a non-destructive method of peat layer depth estimation. The presence of the Sphagneto-Eriophoretum vaginati association, dominated by Sphagnum fimbriatum, Eriophorum vaginatum, Andromeda polifolia, Vaccinium oxycoccos, V. myrtillus, V. vitis-idaea, Polytrichum commune, Picea excelsa, Pinus sylvestris and Betula verrucosa was found to predict the existence of the peat layer but not its depth. Out of the seven identified vegetation types, one type was associated with a very thin or no peat layer, one type was characterised by the presence of a thick (over 100 cm peat layer and five types indicated the presence of variable average depths of the peat layer. pH values correlated with peat layer depth only within the vegetation type associated with thick peat layers.

  14. Estructura comunitaria de corales zooxantelados (Anthozoa: Scleractinia en el arrecife coralino de Carrizales, Pacífico Mexicano

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    Héctor Reyes-Bonilla

    2013-06-01

    Full Text Available El conocimiento ecológico de corales arrecifales en el Pacífico mexicano es escaso, por lo que el objetivo de este trabajo fue determinar la estructura de la comunidad de corales hermatípicos en el arrecife de Carrizales, Colima, mediante el uso de transectos y buceo autónomo (junio y octubre 2005, septiembre 2006. De las 13 especies de corales encontradas, Pocillopora verrucosa fue la más abundante y siete representan nuevos registros, sobresaliendo Psammocora contigua, primer registro para el Pacífico Oriental. No hubo diferencias significativas de abundancia entre profundidades, pero la zona somera presenta una mayor cobertura. Este sitio presenta una de las riquezas y cobertura de coral más alta (61% en el Pacífico Mexicano y valores de diversidad (H´=0.44±0.02, uniformidad (J´=0.76±0.02, y de diferenciación taxonómica (Δ*=45.87±3.16 relativamente altos. Actualmente la región no presenta grandes perturbaciones pero el creciente desarrollo económico de Manzanillo, uno de los principales puertos comerciales del país, además del creciente número de turistas, podrían afectar al arrecife, por lo que se sugiere implementar medidas de protección con el fin de mantener al arrecife más importante del litoral de Colima.

  15. Histamine 1 Receptor Blockade Enhances Eosinophil-Mediated Clearance of Adult Filarial Worms.

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    Ellen Mueller Fox

    Full Text Available Filariae are tissue-invasive nematodes that cause diseases such as elephantiasis and river blindness. The goal of this study was to characterize the role of histamine during Litomosoides sigmodontis infection of BALB/c mice, a murine model of filariasis. Time course studies demonstrated that while expression of histidine decarboxylase mRNA increases throughout 12 weeks of infection, serum levels of histamine exhibit two peaks-one 30 minutes after primary infection and one 8 weeks later. Interestingly, mice treated with fexofenadine, a histamine receptor 1 inhibitor, demonstrated significantly reduced worm burden in infected mice compared to untreated infected controls. Although fexofenadine-treated mice had decreased antigen-specific IgE levels as well as lower splenocyte IL-5 and IFNγ production, they exhibited a greater than fourfold rise in eosinophil numbers at the tissue site where adult L. sigmodontis worms reside. Fexofenadine-mediated clearance of L. sigmodontis worms was dependent on host eosinophils, as fexofenadine did not decrease worm burdens in eosinophil-deficient dblGATA mice. These findings suggest that histamine release induced by tissue invasive helminths may aid parasite survival by diminishing eosinophilic responses. Further, these results raise the possibility that combining H1 receptor inhibitors with current anthelmintics may improve treatment efficacy for filariae and other tissue-invasive helminths.

  16. Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy.

    Science.gov (United States)

    Babayan, Simon A; Read, Andrew F; Lawrence, Rachel A; Bain, Odile; Allen, Judith E

    2010-10-19

    Humans and other mammals mount vigorous immune assaults against helminth parasites, yet there are intriguing reports that the immune response can enhance rather than impair parasite development. It has been hypothesized that helminths, like many free-living organisms, should optimize their development and reproduction in response to cues predicting future life expectancy. However, immune-dependent development by helminth parasites has so far eluded such evolutionary explanation. By manipulating various arms of the immune response of experimental hosts, we show that filarial nematodes, the parasites responsible for debilitating diseases in humans like river blindness and elephantiasis, accelerate their development in response to the IL-5 driven eosinophilia they encounter when infecting a host. Consequently they produce microfilariae, their transmission stages, earlier and in greater numbers. Eosinophilia is a primary host determinant of filarial life expectancy, operating both at larval and at late adult stages in anatomically and temporally separate locations, and is implicated in vaccine-mediated protection. Filarial nematodes are therefore able to adjust their reproductive schedules in response to an environmental predictor of their probability of survival, as proposed by evolutionary theory, thereby mitigating the effects of the immune attack to which helminths are most susceptible. Enhancing protective immunity against filarial nematodes, for example through vaccination, may be less effective at reducing transmission than would be expected and may, at worst, lead to increased transmission and, hence, pathology.

  17. Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline

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    Alexander Yaw Debrah

    2011-01-01

    Full Text Available Infection with the filarial nematode Wuchereria bancrofti can lead to lymphedema, hydrocele, and elephantiasis. Since adult worms cause pathology in lymphatic filariasis (LF, it is imperative to discover macrofilaricidal drugs for the treatment of the infection. Endosymbiotic Wolbachia in filariae have emerged as a new target for antibiotics which can lead to macrofilaricidal effects. In Ghana, a pilot study was carried out with 39 LF-infected men; 12 were treated with 200 mg doxycycline/day for 4 weeks, 16 were treated with a combination of 200 mg doxycycline/day + 10 mg/kg/day rifampicin for 2 weeks, and 11 patients received placebo. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia, and filarial dance sign (FDS. Both 4-week doxycycline and the 2-week combination treatment reduced Wolbachia load significantly. At 18 months posttreatment, four-week doxycycline resulted in 100% adult worm loss, and the 2-week combination treatment resulted in a 50% adult worm loss. In conclusion, this pilot study with a combination of 2-week doxycycline and rifampicin demonstrates moderate macrofilaricidal activity against W. bancrofti.

  18. Carcinoma epidermoide como complicação letal de lesões crônicas de cromoblastomicose Chromoblastomycosis associated with a lethal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Edoardo Torres

    2010-04-01

    Full Text Available A cromoblastomicose é uma micose subcutânea, ocasionada por fungos dermatófitos, dos gêneros: Fonsecaea, Phialophora e Cladophialophora. As complicações habituais são: infecções secundárias, linfedema e elefantíase. Em lesões crônicas, tem-se documentado malignização. Relatamos um caso de um homem de 72 anos de idade, com cromoblastomicose de 30 anos de evolução, em região glútea, com desenvolvimento de carcinoma epidermoide.Chromoblastomycosis is a subcutaneous mycosis caused by the dermatophytic fungi Fonsecaea, Phialophora and Cladophialophora. Usual complications include secondary infection, lymphedema and elephantiasis. Associated malignancies have been found in chronic cases. This case report describes a 72 year-old male with a 30 year history of chromoblastomycosis in the gluteal region, who went on to develop a squamous cell carcinoma.

  19. Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy.

    Directory of Open Access Journals (Sweden)

    Simon A Babayan

    Full Text Available Humans and other mammals mount vigorous immune assaults against helminth parasites, yet there are intriguing reports that the immune response can enhance rather than impair parasite development. It has been hypothesized that helminths, like many free-living organisms, should optimize their development and reproduction in response to cues predicting future life expectancy. However, immune-dependent development by helminth parasites has so far eluded such evolutionary explanation. By manipulating various arms of the immune response of experimental hosts, we show that filarial nematodes, the parasites responsible for debilitating diseases in humans like river blindness and elephantiasis, accelerate their development in response to the IL-5 driven eosinophilia they encounter when infecting a host. Consequently they produce microfilariae, their transmission stages, earlier and in greater numbers. Eosinophilia is a primary host determinant of filarial life expectancy, operating both at larval and at late adult stages in anatomically and temporally separate locations, and is implicated in vaccine-mediated protection. Filarial nematodes are therefore able to adjust their reproductive schedules in response to an environmental predictor of their probability of survival, as proposed by evolutionary theory, thereby mitigating the effects of the immune attack to which helminths are most susceptible. Enhancing protective immunity against filarial nematodes, for example through vaccination, may be less effective at reducing transmission than would be expected and may, at worst, lead to increased transmission and, hence, pathology.

  20. Using Qualitative Methods to Explore Lay Explanatory Models, Health-Seeking Behaviours and Self-Care Practices of Podoconiosis Patients in North-West Ethiopia.

    Directory of Open Access Journals (Sweden)

    Harrison S Banks

    2016-08-01

    Full Text Available Podoconiosis (endemic non-filarial elephantiasis is a chronic, non-infectious disease resulting from exposure of bare feet to red-clay soil in tropical highlands. This study examined lay beliefs about three under-researched aspects of podoconiosis patients' care: explanatory models, health-seeking behaviours and self-care.In-depth interviews and focus group discussions were undertaken with 34 participants (19 male, 15 female between April-May 2015 at podoconiosis treatment centres across East and West Gojjam regions in north-west Ethiopia.Explanatory models for podoconiosis included contamination from blood, magic, soil or affected individuals. Belief in heredity or divine punishment often delayed clinic attendance. All participants had tried holy water treatment and some, holy soil. Herbal treatments were considered ineffectual, costly and appeared to promote fluid escape. Motivators for clinic attendance were failure of traditional treatments and severe or disabling symptoms. Patients did not report self-treatment with antibiotics. Self-care was hindered by water being unavailable or expensive and patient fatigue.A pluralistic approach to podoconiosis self-treatment was discovered. Holy water is widely valued, though some patients prefer holy soil. Priests and traditional healers could help promote self-care and "signpost" patients to clinics. Change in behaviour and improving water access is key to self-care.

  1. Lymphangiogenesis and lymphatic remodeling induced by filarial parasites: implications for pathogenesis.

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    Sasisekhar Bennuru

    2009-12-01

    Full Text Available Even in the absence of an adaptive immune system in murine models, lymphatic dilatation and dysfunction occur in filarial infections, although severe irreversible lymphedema and elephantiasis appears to require an intact adaptive immune response in human infections. To address how filarial parasites and their antigens influence the lymphatics directly, human lymphatic endothelial cells were exposed to filarial antigens, live parasites, or infected patient serum. Live filarial parasites or filarial antigens induced both significant LEC proliferation and differentiation into tube-like structures in vitro. Moreover, serum from patently infected (microfilaria positive patients and those with longstanding chronic lymphatic obstruction induced significantly increased LEC proliferation compared to sera from uninfected individuals. Differentiation of LEC into tube-like networks was found to be associated with significantly increased levels of matrix metalloproteases and inhibition of their TIMP inhibitors (Tissue inhibitors of matrix metalloproteases. Comparison of global gene expression induced by live parasites in LEC to parasite-unexposed LEC demonstrated that filarial parasites altered the expression of those genes involved in cellular organization and development as well as those associated with junction adherence pathways that in turn decreased trans-endothelial transport as assessed by FITC-Dextran. The data suggest that filarial parasites directly induce lymphangiogenesis and lymphatic differentiation and provide insight into the mechanisms underlying the pathology seen in lymphatic filariasis.

  2. Filarial lymphedema is characterized by antigen-specific Th1 and th17 proinflammatory responses and a lack of regulatory T cells.

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    Subash Babu

    Full Text Available Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients.To elucidate the role of CD4(+ T cell subsets in the development of lymphatic pathology, we examined specific sets of cytokines in individuals with filarial lymphedema in response to parasite antigen (BmA and compared them with responses from asymptomatic infected individuals. We also examined expression patterns of Toll-like receptors (TLR1-10 and Nod-like receptors (Nod1, Nod2, and NALP3 in response to BmA. BmA induced significantly higher production of Th1-type cytokines-IFN-gamma and TNF-alpha-in patients with lymphedema compared with asymptomatic individuals. Notably, expression of the Th17 family of cytokines-IL-17A, IL-17F, IL-21, and IL-23-was also significantly upregulated by BmA stimulation in lymphedema patients. In contrast, expression of Foxp3, GITR, TGFbeta, and CTLA-4, known to be expressed by regulatory T cells, was significantly impaired in patients with lymphedema. BmA also induced significantly higher expression of TLR2, 4, 7, and 9 as well Nod1 and 2 mRNA in patients with lymphedema compared with asymptomatic controls.Our findings implicate increased Th1/Th17 responses and decreased regulatory T cells as well as regulation of Toll- and Nod-like receptors in pathogenesis of filarial lymphedema.

  3. Management of ulcers in lymphoedematous limbs

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    Vishnu M Karnasula

    2012-01-01

    Full Text Available Lymphoedema is a progressive condition that can have a marked physical and psychological impact on affected patients and significantly reduce the quality of life. The ulcers on chronic lymphoedema patient, which often also makes it impossible for them to work. If left untreated, tends to progress or worsen. Ulcers in lymphoedema patients, therefore, represent not only a medical but also a psychological problem. The treatment is often regarded as being worse than it actually is. In our study of more than 25 years shows around 10% cases are due to chronic lymphodema. Ulcers of chronic lymphoedema are classified into four stages according to their presentation. Their management depends upon their stage of presentation. Patients with chronic lymphoedema and ulceration require a different approach to treatment. The specific issues associated with managing the patient with lymphoedematous ulceration include, limb shape distortion i.e., elephantiasis, care of the skin creases and folds, and swelling of the toes and fore foot. Stage I ulcers will heal with conservative treatment without any surgical intervention. Stage II ulcers needs debridement of the wound and split-thickness skin grafting. The most difficult to treat are the stage III and IV ulcers, due to associated skin changes and reduced vascularity. These cases need debulking along with excision of the ulcer. In order to prevent recurrence of the ulcer in all the four stages needs prolonged follow-up and limb care.

  4. Using Qualitative Methods to Explore Lay Explanatory Models, Health-Seeking Behaviours and Self-Care Practices of Podoconiosis Patients in North-West Ethiopia

    Science.gov (United States)

    Banks, Harrison S.; Tsegay, Girmay; Wubie, Moges; Tamiru, Abreham; Davey, Gail; Cooper, Max

    2016-01-01

    Background Podoconiosis (endemic non-filarial elephantiasis) is a chronic, non-infectious disease resulting from exposure of bare feet to red-clay soil in tropical highlands. This study examined lay beliefs about three under-researched aspects of podoconiosis patients’ care: explanatory models, health-seeking behaviours and self-care. Methods In-depth interviews and focus group discussions were undertaken with 34 participants (19 male, 15 female) between April-May 2015 at podoconiosis treatment centres across East and West Gojjam regions in north-west Ethiopia. Results Explanatory models for podoconiosis included contamination from blood, magic, soil or affected individuals. Belief in heredity or divine punishment often delayed clinic attendance. All participants had tried holy water treatment and some, holy soil. Herbal treatments were considered ineffectual, costly and appeared to promote fluid escape. Motivators for clinic attendance were failure of traditional treatments and severe or disabling symptoms. Patients did not report self-treatment with antibiotics. Self-care was hindered by water being unavailable or expensive and patient fatigue. Conclusion A pluralistic approach to podoconiosis self-treatment was discovered. Holy water is widely valued, though some patients prefer holy soil. Priests and traditional healers could help promote self-care and “signpost” patients to clinics. Change in behaviour and improving water access is key to self-care. PMID:27536772

  5. Dermatological changes of amputation stump

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    Arora P

    1993-01-01

    Full Text Available Dermatological changes of stumps of 174 amputees are presented. The commonest dermatological change recorded at the site of amputation stump was hyperpigmentation in 46 (26.4% followed by callosities in 32 (18.3%, scaling in 29 (16.7%, cutaneous atrophy in 20 (11.5%, lichenification in 19(10.9%, traumatic ulcer and bacterial infections in 18 (10.3% each, hypertrophic scar in 14 (8.1%, hypopigmentation and corns in 13 (7.4% each, verrucous hypertrophy of stump in 12 (6.9%, dermatophytic infection in 5(2.9%, stump oedema and phantom limb in 4 (2.3% each, intertriginous dermatitis in 3( 1.7%, allergic contact dermatitis (resin and frictional eczema in 2(1.1% each. Epidermoid cyst, keloid formation, anaesthesia, gangrene and cutaneous horn were recorded in 1 (0.6% each. Atrophy (epidermal and derma, anaesthesia, alopecia and elephantiasis of the stump have not been documented in the literature earlier.

  6. The Impact of Health Service of the Community Hospital Located in Thailand’s Border: migrant from Burma, LAOS, and Cambodia

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    Orathai - Srithongtham

    2013-11-01

    Full Text Available The denial of difficult, dangerous and dirty work done by the Thai People has been the major cause of migrant substitution in Thailand which triggered the urgent need for proper health care. This study was aim to explain the burden and impact of providing health service to the trans-national migrant in community hospital at border area of Laos, Burma and Cambodia. Therefore survey research and data collecting was used through quantitative and qualitative methods. Results: Khemarat and Klong Yai hospital: the financial burden was high however Mae Sai hospital has strong income with less expenditure. The impact of three hospitals was 1 the only way of solving the financial burden is by using the hospital’s money. 2 No data system about trans-nation’s migrant health services has been applied so far by any hospitals here in Thailand 3 Man power of hospital is depended on the Thai people which doesn’t include the migrant which is approximately 50% 4 The language and the cultural had generated several obstacles to health service 5 Problem of prevention and control of Communicable disease such as Malaria, Dengue Hemorrhagic fever, Tuberculosis, and Elephantiasis, 6 No Referral system between Thailand and neighboring countries.  Recommendations: it should be setting the strategy of AEC’s health system at nearby country, concern with the trans-national migrants, and develop the data system of health service of trans-national migrant.

  7. Involvement of Hookworm Co-Infection in the Pathogenesis and Progression of Podoconiosis: Possible Immunological Mechanism

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    Damilare O. Famakinde

    2018-03-01

    Full Text Available Podoconiosis is an endemic, non-infectious, geochemical and non-filarial inflammatory cause of tropical elephantiasis. The immunology of podoconiosis is not yet expressly understood. In spite of this, co-infection and co-morbidity with the infectious, soil-transmitted hookworm disease that causes iron deficiency anemia has been found to be predominant among affected individuals living in co-endemic settings, thus creating a more complex immunological interplay that still has not been investigated. Although deworming and iron-rich nutrient supplementation have been suggested in podoconiosis patients living under resource-poor conditions, and it is thought that hookworm infection may help to suppress inflammatory responses, the undisputed link that exists between a non-infectious and an infectious disease may create a scenario whereby during a co-infection, treatment of one exacerbates the other disease condition or is dampened by the debilitation caused by the other. In this paper, we elaborate on the immunopathogenesis of podoconiosis and examine the possible immunological dynamics of hookworm co-infection in the immunopathology of podoconiosis, with a view toward improved management of the disease that will facilitate its feasible elimination.

  8. Prevalence and clinical aspects of Wuchereria bancrofti among inhabitants of a resource limited irrigation project community, North Central Nigeria

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    Ebube Charles Amaechi

    2017-01-01

    Full Text Available Objective: To assess the prevalence and clinical manifestations of lymphatic filariasis among inhabitants of the study area. Methods: A total of 1 069 persons of different age groups were examined using immunochromatographic test which detected Wuchereria bancrofti (W. bancrofti antigens by finger prick blood collection. Physical examinations of the subjects were also carried out to check for signs of the infection on the individuals. Results: Of these, 36 (3.4% were infected with W. bancrofti. Males showed a higher prevalence than females (4.0% vs. 2.8%, P < 0.05. Those that fell in the age group of 70 years and above were the most infected (23.8%. Regarding signs and symptoms of the disease, periodic fever was reported the most by the subjects (7.5% followed by crawling sensation (4.9%. Periodic fever and crawling sensation tended to appear much earlier in life, while tenderness of limbs, elephantiasis and hydrocele were symptoms that showed up from the fifth decade of life. Conclusions: Our study showed that lymphatic filariasis was caused by W. bancrofti as a serious health problem in irrigation communities of Nigeria. Realistic and sustained health interventions are required to effectively control the disease in this community and other related areas of Nigeria.

  9. Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease.

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    R Anuradha

    Full Text Available Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients. Dysregulated host inflammatory responses leading to systemic immune activation are thought to play a central role in filarial disease pathogenesis. We measured the plasma levels of microbial translocation markers, acute phase proteins, and inflammatory cytokines in individuals with chronic filarial pathology with (CP Ag+ or without (CP Ag- active infection; with clinically asymptomatic infections (INF; and in those without infection (endemic normal [EN]. Comparisons between the two actively infected groups (CP Ag+ compared to INF and those without active infection (CP Ag- compared to EN were used preliminarily to identify markers of pathogenesis. Thereafter, we tested for group effects among all the four groups using linear models on the log transformed responses of the markers. Our data suggest that circulating levels of microbial translocation products (lipopolysaccharide and LPS-binding protein, acute phase proteins (haptoglobin and serum amyloid protein-A, and inflammatory cytokines (IL-1β, IL-12, and TNF-α are associated with pathogenesis of disease in lymphatic filarial infection and implicate an important role for circulating microbial products and acute phase proteins.

  10. Using Qualitative Methods to Explore Lay Explanatory Models, Health-Seeking Behaviours and Self-Care Practices of Podoconiosis Patients in North-West Ethiopia.

    Science.gov (United States)

    Banks, Harrison S; Tsegay, Girmay; Wubie, Moges; Tamiru, Abreham; Davey, Gail; Cooper, Max

    2016-08-01

    Podoconiosis (endemic non-filarial elephantiasis) is a chronic, non-infectious disease resulting from exposure of bare feet to red-clay soil in tropical highlands. This study examined lay beliefs about three under-researched aspects of podoconiosis patients' care: explanatory models, health-seeking behaviours and self-care. In-depth interviews and focus group discussions were undertaken with 34 participants (19 male, 15 female) between April-May 2015 at podoconiosis treatment centres across East and West Gojjam regions in north-west Ethiopia. Explanatory models for podoconiosis included contamination from blood, magic, soil or affected individuals. Belief in heredity or divine punishment often delayed clinic attendance. All participants had tried holy water treatment and some, holy soil. Herbal treatments were considered ineffectual, costly and appeared to promote fluid escape. Motivators for clinic attendance were failure of traditional treatments and severe or disabling symptoms. Patients did not report self-treatment with antibiotics. Self-care was hindered by water being unavailable or expensive and patient fatigue. A pluralistic approach to podoconiosis self-treatment was discovered. Holy water is widely valued, though some patients prefer holy soil. Priests and traditional healers could help promote self-care and "signpost" patients to clinics. Change in behaviour and improving water access is key to self-care.

  11. Lymphogranuloma venereum: an old, forgotten re-emerging systemic disease.

    Science.gov (United States)

    Dal Conte, I; Mistrangelo, M; Cariti, C; Chiriotto, M; Lucchini, A; Vigna, M; Morino, M; Di Perri, G

    2014-03-01

    Lymphogranuloma venereum (LGV) is a sexually transmitted infection endemic in parts of Africa, Asia, South America, and the Caribbean, but once was rarely observed in Western countries, where most cases were considered to be imported. However, recent outbreaks have been reported in Europe, Australia, New Zealand, the United States and Canada, mainly among HIV positive men who have sex with men, signaling LGV re-emergence. The etiological agent of LGV is Chlamydia trachomatis serotypes L1, L2 and L3, and current outbreaks are mostly sustained by L2b type. The clinical course can be classically divided into three stages: an initial papule, which may ulcerate at the site of inoculation, followed by regional lymphoadenopathy (second stage, generally unilateral). In the tertiary stage, lymphatic obstruction, with elephantiasis of genitalia, and rectal involvement can lead to the formation of strictures and fistulae that may require surgical treatment. Recent cases are observed mainly among HIV positive people, often co-infected with HCV and others STIs, engaging in high-risk sexual practices. The main clinical picture is a relative new entity characterized by progressive ulcerative proctitis, the so called anorectal syndrome. Diagnosis is often delayed, requires a high index of clinical suspicion and must rely on the use of nucleic acid amplification tests. The differential diagnosis of proctitis should include LGV infection. Gastroenterologists, coloproctologists, dermatologists and other specialists need to be aware of LGV proctitis to avoid diagnostic delay and progression of disease to the tertiary stage.

  12. Stigma reduction and improved knowledge and attitudes towards filariasis using a comic book for children.

    Science.gov (United States)

    el-Setouhy, Maged A; Rio, Francisco

    2003-04-01

    WHO has initiated a global program for lymphatic filariasis (LF) elimination by year 2020. A comic book was designed to improve knowledge and attitudes of Egyptian school children, which included messages on the acceptability of Mass Drug Administration (MDA) and stigma reduction. Comic book administration significantly reduced the fear of the studied children from LF as a killer disease. It helped in positively changing the attitudes of the children towards Elephantiasis patients (p-value comic book also reduced the number of children who had earlier stated that they would avoid someone with LF. Knowledge about the ability of treating and preventing LF was also significantly increased among the children after reading the comic book. Moreover, comic book reading helped in raising the awareness towards MDA as the method of choice in preventing LF. Most of the children liked the comic book and its contents. Importantly, 96.2% found this book easy to understand. Many of relatives and friends read the comic book within 2 weeks after distribution. A well-accepted comic book for children is a proven way to reduce stigma and increase knowledge about disease prevention and treatment.

  13. La novela historica hispanoamericana actual: Carpentier, Fuentes y Galeano

    Science.gov (United States)

    Rivera-Ocasio, Gladys

    1998-10-01

    This dissertation studies the evolution of the historical novel in Spanish America during the second half of the twentieth century, focusing on the following works: El siglo de las luces (1962) by the Cuban Alejo Carpentier, Terra nostra (1975), by the Mexican Carlos Fuentes, and Memoria del fuego (1982-1986), by the Uruguayan Eduardo Galeano. The thesis' aim is to describe, analyze and suggest the causes for the breakdown of the modern historical narrative, decade by decade, from the sixties to the present. The line between what the dissertation identifies as modern and postmodern historical novels is drawn by radical changes in the structure of the aesthetic representation of history. Taking as its point of departure the implicit and sometimes explicit rules or poetics that conditioned the historical novel as a subgenre since Scott and Manzoni, the thesis explores how the new, postmodern novel, shatters the twin columns that supported that modern model: verisimilitude and linearity. This is the thesis's main work on the formal or aesthetic sphere of the recent Spanish American historical novel. But the aesthetic is intimately tied to two other spheres: the cosmological and the ontological (political and moral). If, on the one hand, the catastrophic state that the postmodern novel exhibits (the acceleration of its narrative particles, as it were) reveals itself as the mirror image of postmodern paradigms such as the fragment and catastrophe itself, on the other, its chaotic liberation reflects the historical ``spirit'' within it is produced. This is so because not only in its content, but also in its very form, the postmodern novel is part of that catastrophe. The postmodern novel's chaotic text posits the disintegration of all versionas of the emancipation project, or of the pursuit of an identity, that (the Cuban Revolution included) is closely allied to the totalizing drive that characterizes the spirit of modern times. The dissertation's hypothesis is that

  14. Human Periapical Cysts-Mesenchymal Stem Cells Cultured with Allogenic Human Serum are a “clinical-grade” construct alternative to bovine fetal serum and indicated in the regeneration of endo-periodontal tissues

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    Marco Tatullo

    2018-06-01

    Full Text Available Aim: Our research investigated the use of human serum (HS as a safe and clinical-grade culture medium, using a new cell-model: hPCy-MSCs. This article is aimed to concretely applicate the concept of “waste-based regenerative dentistry” to translate it in future endo-periodontal applications. Methodology: HPCy-MSCs were cultured in 2 different mediums, both containing α-MEM: the 1st with 10% FBS (Control group, and the 2nd with 10% human serum (Test group.Cell proliferation and stemness assays, gene expression, immunophenotypic analysis and osteogenic differentiation were performed to verify our hypothesis. cDNA samples were amplified with qPCR.Experiments were performed in triplicate and analysed with statistical software. Results: The hPCy-MSCs cultivated in a medium with HS were morphologically similar to those cultivated with FBS, and showed a significantly higher proliferation rate. Von Kossa's staining revealed that osteoblasts from hPCy-MSCs in HS implemented with osteogenic induction factors, showed a better osteogenic activity, also confirmed by a significant upregulation of osteopotin (OPN and matrix extracellular phosphoglycoprotein (MEPE. Conclusions: HPCy-MSCs cultivated in HS showed phenotypic stability and a clear regenerative binding, thus, suggesting these two components as a clinically-grade construct for future endo-periodontal therapies. Riassunto: Obiettivi: La nostra ricerca ha analizzato l’utilizzo del siero umano (HS come mezzo di coltura sicuro e “clinical-grade”, per uso clinico, utilizzando un nuovo modello cellulare: le hPC-MSCs. Questo articolo ha lo scopo di applicare concretamente il concetto di “odontoiatria rigenerativa basata sui rifiuti biologici”, al fine di tradurlo in future applicazioni endo-periodontali. Materiali e metodi: Le HPCy-MSCs sono state coltivate in 2 mezzi di coltura diversi, entrambi contenenti α-MEM: il primo con 10% di FBS (gruppo di controllo e il secondo con il 10% di siero

  15. Item Analysis di una prova di lettura a scelta multipla della certificazione di italiano per stranieri CILS (livello B1; sessione estiva 2012

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    Paolo Torresan

    2014-10-01

    Full Text Available Nell’articolo presentiamo un’analisi degli item di una prova di lettura a scelta multipla di livello B1 della certificazione CILS (Università per Stranieri di Siena. L’indagine si muove da una prima ricognizione del testo su cui si basa la prova, con uno studio delle modifiche cui è andata soggetta per mano dell’item writer, per poi ragionare sull’analisi di ogni singolo item, grazie ai dati emersi dalla somministrazione della prova a 161 studenti di italiano di livello corrispondente sparsi per il pianeta. Dalla nostra ricerca si evince che si danno un item ambiguo (# 1, per via della presenza di due chiavi, e un item di difficile risoluzione, per via della mancanza di informazioni utili per desumere il significato del vocabolo cui si riferisce (# 4.In this article we present an analysis of items in a reading multiple-choice test, B1 level, of the CILS certification (Università per Stranieri di Siena. The research starts with a preliminary recognition of the text on which the test is based, with a study of the modifications it has undergone by the item writer’s hand, and proceeds to reason about the analysis of every single item, using data from the ministration of the test to 161 students of Italian in the corresponding level, from all over the planet. From our research it emerges that the test presents an ambiguous item (# 1, with two keys, and a difficult item, without enough information to make clear the meaning of the word it refers to (# 4.

  16. [La combinazione di gemcitabina e oxaliplatino (GEMOX) nel trattamento del carcinoma pancreatico in fase avanzata di malattia: le notizie sulla mia morte sono state esagerate?

    Science.gov (United States)

    Giuliani, Jacopo; Bonetti, Andrea

    2017-12-01

    Riassunto. L'analisi è stata condotta al fine di valutare l'effetto sia sulla sopravvivenza globale (OS) sia sulla sopravvivenza libera da progressione di malattia (PFS) della chemioterapia di combinazione in prima linea per il carcinoma pancreatico in fase avanzata di malattia. La presente analisi è limitata agli studi randomizzati controllati (RCT) di fase III. Successivamente è stata applicata la European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS) agli RCT di fase III analizzati per ricavare uno score relativo all'entità del beneficio clinico ottenuto per ciascun RCT. Sono state calcolate inoltre le differenze in termini di PFS tra i diversi bracci di trattamento rapportandole con i costi dei farmaci necessari per ottenere il beneficio di PFS. La nostra analisi ha valutato 11 RCT di fase III, per un totale di 4572 pazienti. Combinando i costi della terapia con la misura dell'efficacia espressa dalla PFS, è stato ottenuto un costo di 74,12 euro (€) per mese di vita guadagnato in termini di PFS con la combinazione di 5-fluorouracil, leucovorin, irinotecan e oxaliplatino (FOLFIRINOX), 90,14 € per la combinazione di gemcitabina e oxaliplatino (GEMOX) e 4708,7 € per la combinazione di nab-paclitaxel e gemcitabina. Da questo punto di vista riteniamo che l'utilizzo delle "vecche chemioterapie di combinazione" (per es., GEMOX) non dovrebbe essere completamente abbandonato, ma valutato sul singolo paziente, sulla base di diversi fattori (età, ECOG PS, comorbilità, carico di malattia), al fine di ottenere una reale "tailored therapy".

  17. Camminabilità e capacità urbane: valutazione e supporto alla decisione e alla pianificazione urbanistica

    Directory of Open Access Journals (Sweden)

    Ivan Blečić

    2015-06-01

    Full Text Available L’articolo propone una metodologia di valutazione della camminabilità (walkability urbana ed il rispettivo strumento software di supporto alla decisione ed alla pianificazione urbanistica. Nella parte introduttiva discutiamo la rilevanza del concetto di camminabilità per la qualità urbana ed offriamo un suo inquadramento teorico all’interno dell’approccio alle capacità (capability approach. La parte centrale è dedicata alla presentazione del modello spaziale e multicriteriale di valutazione della camminabilità. La nostra costruzione della camminabilità nel modello propone un certo ribaltamento di prospettiva rispetto ai metodi sinora proposti: anziché valutare quanto un determinato luogo è in sé camminabile, il punteggio di camminabilità calcolato riflette come e verso dove una persona può intraprendere una camminata a partire da quel luogo; in altre parole, non quanto è camminabile, ma invece qual è la camminabilità di cui il luogo è dotato. Per questo, il punteggio di camminabilità combina tre componenti: (1 il numero di destinazioni di interesse/opportunità urbane raggiungibili a piedi; (2 le loro distanze; (3 la qualità dei percorsi pedonali verso queste destinazioni. La qualità dei percorsi pedonali è valutata in base a diversi attributi rilevanti per la camminabilità, che fanno riferimento a caratteristiche proprie della strada e dell’ambiente circostante in grado di contribuire a rendere il percorso piacevole, sicuro ed attrattivo. A titolo illustrativo viene nella terza parte dell’articolo presentato un esempio di applicazione del modello alla città di Alghero.

  18. Monogràfic "VI Congrés Internet, Dret i Política. Cloud Computing: El Dret i la Política Pugen al Núvol"

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    Estudis de Dret i Ciència Política

    2011-01-01

    Full Text Available

    L'any 2010 és l'any cloud computing. Així ho afirmen nombrosos analistes i especialistes que veuen que s'expandeixen aplicacions que, en lloc de ser executades a l'ordinador de sobretaula o al portàtil, són hostatjades en un servidor, i a les quals s'accedeix mitjançant un navegador qualsevol. Aquesta expansió és facilitada per la massiva adopció d'ordinadors ultraportàtils i telèfons mòbils intel·ligents, així com per la creixent realitat del teletreball i la col·laboració en xarxa entre administracions, empreses i ciutadans.

    Tenir les dades, els documents de text, els fulls de càlcul, les aplicacions de gestió de clients o d'estocs, i la coordinació de processos i projectes emmagatzemats en servidors de tercers; fer passar les comunicacions personals i professionals per un navegador, o obrir la nostra participació ciutadana a tothom són possibilitats que ens ofereixen noves oportunitats, però també nous reptes sobre com entenem la feina, les relacions professionals o l'exercici de la democràcia.

    Aquests reptes i oportunitats van constituir el punt de trobada de la sisena edició del Congrés Internacional IDP - Internet, Dret i Política, que es va centrar a analitzar i debatre els diferents problemes jurídics i polítics que planteja o pot plantejar la massiva extensió del cloud computing tant a escala professional com personal i ciutadana.

  19. Spazi di gioco nella tragedia: il mondo “altro” in attesa dell’orrore

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    Marina Cavalli

    2016-07-01

    Full Text Available Già il pensiero antico aveva identificato l’attitudine elementare al gioco come necessità primaria di incanalare l’energia fisica esuberante e disordinata, che caratterizza ogni creatura giovane. L’impulso all’agitazione, al movimento scomposto, eccessivo e improvvisato, si traduce in un infantile contatto col mondo basato su attività destrutturate e prive di scopo, in cui l’essenziale è il movimento stesso, l’azione in sé, ben più che non l’effettivo giungere a un risultato dell’azione. Proprio dall’obbligo di contenere e normare questo flusso incontrollato della fisicità infantile nascono, secondo Aristotele, le diverse forme di controllo pedagogico: «I fanciulli devono avere qualcosa da fare, e per questo è perfetto il sonaglio di Archita, che si dà ai più piccoli perché, occupati con esso, non rompano niente delle cose di casa: i bambini infatti non possono stare mai fermi. Per i più grandicelli, il sonaglio di Archita è l’educazione» (Politica, 8, 6, 1340b, 23-31. Ed è questa necessità incontenibile di movimento che già Platone aveva posto come origine prima non solo di ogni atto coreutico, ma anche della gioia stessa dello spettatore (Leggi, 2, 653d-657d: «Ogni creatura giovane non può star ferma col corpo o in silenzio con la voce, e sempre ha l’istinto di muoversi e gridare […] ma per noi anziani è più decoroso starli a guardare, i giovani, lieti del loro gioco e della festa, perché la nostra agilità ormai è perduta. E non è forse per nostalgia di quella agilità, che mettiamo in palio premi per chi meglio risveglia in noi il ricordo della giovinezza?».

  20. Un Manifesto economico per i paesi del Golfo Persico esportatori di petrolio(An Economic Manifesto for the Oil Exporting Countries of the Persian Gulf

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    Hossein Askari

    2012-04-01

    Full Text Available The oil-exporting countries of the Persian Gulf have failed economically and socially. It is time for a radical new approach to managing oil revenues while oil and gas reserves last. We propose an approach to cut the level of oil revenues available to governments to zero while incorporating a formal "Oil Fund for All Generations". Others have proposed and implemented oil funds but in our proposal the government would (in time lose all access to oil revenues; by taking easy money away from governments and rulers, waste, corruption, military expenditures and wars will be reduced, there will be better chance of adopting and implementing rational economic policies, and equity across generations may be enhanced. Hope may be slowly restored to a region that has lost hope. I paesi del Golfo Persico esportatori di petrolio hanno fallito dal punto di vista economico e sociale. È tempo di adottare un approccio radicalmente nuovo alla gestione dei ricavi petroliferi finché vi sono ancora riserve di petrolio e di gas. Noi proponiamo un approccio finalizzato ad azzerare il livello dei ricavi disponibili per i governi, istituendo allo stesso tempo un formale “Fondo petrolifero per tutte le generazioni”. Fondi petroliferi sono stati ipotizzati e realizzati anche da altri, ma nella nostra proposta il governo perderebbe (col tempo qualunque accesso ai ricavi petroliferi; sottraendo denaro facile ai governi e ai sovrani, la probabilità di sprechi, corruzione e guerre risulterebbe ridotta, e vi sarebbe maggiore possibilità di adottare e mettere in pratica politiche economiche razionali finalizzate ad accrescere l’equità tra le generazioni.  JEL Codes: O13, O53, Q48Keywords: Gas; Oil

  1. La neologia de manlleu i de base culta en emissions televisives

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    Imma Creus

    2015-11-01

    Full Text Available Resum: Aquesta contribució als estudis neològics del català usat als mèdia orals, especialment a la televisió, ens permet confirmar que la neologia de manlleu, que ens facilita la denominació de nous objectes i conceptes amb vocabulari forà, prové majoritàriament de l’anglès, esdevingut l’idioma innovatiu per excel·lència en una gran varietat de camps, sobretot en els esports i la tecnologia. A més, la terminologia especialitzada, formada d’arrels clàssiques i afixació culta afavoreix la renovació i l’augment de les habilitats expressives de les llengües en qualsevol àrea científica com a resultat de la ràpida evolució de la nostra societat. S’hi tracta un bon nombre de processos de formació de paraules, com ara la de derivats i compostos cultes, l’habilitació de noms propis, l’acronímia i la siglació, així com l’adaptació al català segons les seves regles ortogràfiques i ortoèpiques.Paraules clau: llengua dels mèdia orals, llenguatge de la ràdio i la TV, manlleus de l’anglès, composició culta, afixació en terminologia especialitzada, siglació, acronímia.

  2. Relat del Congrés IDP 2012

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    Ignacio Alamillo Domingo

    2012-12-01

    Full Text Available

    Aquest article conté el relat del VIII Congrés Internet, Dret i Política, organitzat per la Universitat Oberta de Catalunya i que va tenir lloc a les instal·lacions del CosmoCaixa a Barcelona els dies 9 i 10 de juliol de 2012.

    En el Congrés, amb la temàtica de l'entreteniment en línia com a fil conductor, hi va haver tres ponències principals, dues taules de debat i la presentació de vint-i-vuit comunicacions, agrupades en quatre grans dominis: propietat intel·lectual, comerç electrònic i joc en línia, govern i polítiques reguladores, i privadesa.

    Les intervencions del Congrés, molt diverses, han posat de manifest una transformació important del model de relacions a internet, que afecta el substrat sociològic en el qual es va basar el disseny de normes com la propietat intel·lectual, la formalització contractual de les relacions de consum i la protecció de dades personals i altres drets fonamentals, de manera que es pot anticipar la necessitat de més regulació i més bona, realista i equilibrada: més harmonitzada dins de la Unió Europea, i més ben coordinada amb la legislació dels Estats Units, sense renunciar als principis i drets constitucionals de la nostra tradició.

  3. Current and emerging treatments for the management of osteogenesis imperfecta

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    Elena Monti

    2010-08-01

    Full Text Available Elena Monti1, Monica Mottes1, Paolo Fraschini2, PierCarlo Brunelli3, Antonella Forlino4, Giacomo Venturi1, Francesco Doro1, Silvia Perlini1, Paolo Cavarzere1, Franco Antoniazzi11Department of Life Sciences and Reproduction, Pediatric Clinic University of Verona, Verona, Italy; 2Istituto Di Ricovero e Cura a Carattere Scientifico, ‘E. Medea’, Associazione La Nostra Famiglia, Bosisio Parini (LC, Italy; 3Divisione di Ortopedia Pediatrica, Spedali Civili, Brescia, Italy; 4Department of Biochemistry “A. Castellani”, University of Pavia, ItalyAbstract: Osteogenesis imperfecta (OI is the most common bone genetic disorder and it is characterized by bone brittleness and various degrees of growth disorder. Clinical severity varies widely; nowadays eight types are distinguished and two new forms have been recently described although not yet classified. The approach to such a variable and heterogeneous disease should be global and therefore multidisciplinary. For simplicity, the objectives of treatment can be reduced to three typical situations: the lethal perinatal form (type II, in which the problem is survival at birth; the severe and moderate forms (types III–IX, in which the objective is ‘autonomy’; and the mild form (type I, in which the aim is to reach ‘normal life’. Three types of treatment are available: non-surgical management (physical therapy, rehabilitation, bracing and splinting, surgical management (intramedullary rod positioning, spinal and basilar impression surgery and medical-pharmacological management (drugs to increase the strength of bone and decrease the number of fractures as bisphosphonates or growth hormone, depending on the type of OI. Suggestions and guidelines for a therapeutic approach are indicated and updated with the most recent findings in OI diagnosis and treatment.Keywords: osteogenesis imperfecta, bone genetic disorder, bone brittleness, “brittle bone disease”, connective tissue malfunction, short

  4. Lo sport come filosofia educativa e sociale: una prospettiva decostruzionista

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    Emanuele Isidori

    2013-04-01

    Full Text Available Lo scopo del presente articolo è quello di procedere, utilizzando un approccio filosofico decostruzionista, ad una disamina dello sport come oggetto filosofico, mostrandone le contraddizioni interne, i paradossi e le aporie che lo caratterizzano in quanto concetto educativo-culturale e fenomeno sociale. L’analisi si svilupperà riflettendo su tre temi tipici del dibattito decostruzionista: quello del phármakon, dell’identità e dell’ospitalità, tema quest’ultimo tipico anche del pensiero debole che presenta forti interconnessioni con il pensiero decostruzionista e postmoderno. Lo studio, che utilizzerà il tipico approccio teoretico-prassico della filosofia dell’educazione, evidenzierà sia i meccanismi concettuali che talvolta impediscono allo sport di essere pensato come pratica realmente educativa ed in grado di generare l’inclusione sociale, sia quelli che invece ne permettono la teorizzazione e l’implementazione in questa prospettiva. Lo studio si concluderà mostrando come per concepire realmente lo sport nella prospettiva di un autentico strumento educativo e di miglioramento della vita sociale sia necessaria una vera e propria rivoluzione etica e culturale della nostra società. Lo sport, infatti, in quanto sottosistema della società, rappresenta lo specchio dei valori di quest’ultima e non solo ne incarna i difetti, le contraddizioni ma anche le sue buone prassi. Questa rivoluzione deve necessariamente passare attraverso l’educazione; soltanto così, infatti, sarà possibile costruire quella società nuova, fondata sulla paidéia sportiva, che De Coubertin sognava per l’umanità futura.

  5. Per una lettura laica della teologia medievale

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    Dino Buzzetti

    2010-02-01

    Full Text Available È possibile operare una forma di epoché sui concetti di carattere teologico? Ed è possibile riflettere sulla loro importanza, prescindendo dalla loro portata religiosa? I concetti teologici riescono a dirci qualcosa, se si trascura il loro riferimento essenziale alla nostra relazione con un essere divino? La risposta a queste domande consente di comprendere che cosa significhi essere un studioso laico della filosofia medievale, mentre è impossibile discutere tale problema senza prendere in considerazione anche la teologia medievale. Tutto ciò dunque riguarda non solo la natura della teologia, ma anche l’idea stessa di laicità. Dunque una storiografia del pensiero medievale pienamente consapevole di se stessa deve studiare il discorso teologico e affrontare in profondità la portata teorica di questo problema. Si può concludere che per una lettura laica della teologia medievale è paradossalmente essenziale cogliere proprio il senso intimo del pensiero religioso e le forme storicamente determinate della sua effettiva concettualizzazione.  Is some form of epoché possible on theological concepts? In which way? Is it possible consider their importance leaving their religious scope aside? Can the theological concepts tell us something unless we consider their essential reference to our relationship with a divine being? The answer to these questions let us to understand what means to be a secular (laico scholar of medieval philosophy. It's impossible conversely to discuss this problem without dealing with medieval theology. And this concerns not only the nature of theology, but also and deeply the same idea of secularism (laicità. Therefore a fully aware historiography of medieval thought has to understand the theological speech and to encounter the depth of this theoretical question. So we can conclude that for a secular reading of the medieval theology is paradoxically essential to catch the intimate sense of religious thought and the

  6. La literatura, més que llibres

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    María-del-Mar Garcia-Vilanova

    2008-12-01

    Full Text Available La literatura, més que llibres és el nom d’un espai web pensat com a suport a les clases presencials de literatura de 3r i 4t d’ESO. L’objectiu és presentar d’una manera atractiva les diferents etapes, els autors i les obres de la literatura catalana i treballar-los a partir d’activitats pràctiques que permetin a l’alumnat introduir-s’hi de manera actual. La finalitat d’aquest estudi és posar en contacte l’alumnat amb algunes èpoques, autors, personatges, obres, etc. significatius de la nostra literatura, en certa manera encara força vigents en l’actualitat. Una idea important que ha guiat aquest projecte ha estat la de connectar el passat amb el present i fer veure a l’alumnat l’actualitat de molts dels clàssics. El lloc està organitzat cronològicament en quatre cursos i cadascun d’ells s’estructura en diferents temes. S’ha fet una selecció, evidentment discutible, d’etapes, autors i obres per a cadascun dels períodes de la literatura catalana, dels quals se’n proposa el treball a partir dels diferents recursos que permet utilitzar el suport moodle que s’ha fet servir: PowerPoints, enllaços a pàgines web, qüestionaris, cançons, vídeos, etc.

  7. A representation of Power between cinema and theatre: Elio De Capitani’s Berlusconi

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    Laura Mariani

    2015-12-01

    Full Text Available Che fine ha fatto un’incarnazione grandiosa del potere come Riccardo III di Shakespeare, dopo essere passato per Ubu re di Jarry e Artuto Ui di Brecht? Nella nostra epoca postideologica il pubblico chiede storie e non La Storia; personaggi in cui bene e male, forza e debolezza si mostrano nella quotidianità mescolando pubblico e privato. Il saggio analizza le rappresentazioni del potere offerte da Elio De Capitani, attore regista teatrale legato alla tradizione recitativa italiana, sensibile alla tradizione anglosassone e ai linguaggi della contemporaneità; e sceglie l’interpretazione di Berlusconi nel Caimano di Moretti per la sua popolarità e per le sue implicazioni nel contesto italiano. La metodologia si basa sulla distinzione fra Academic history e Stage history. In un teatro che lega la sperimentazione al testo e al personaggio, in un cinema che continua ad avvalersi dei saperi teatrali, il lavoro dell’attore va messo al centro e va studiato nella sua concretezza e singolarità: processo, esiti artistici, rapporto con la società dello spettacolo. Il saggio mostra come gli attori siano dentro il presente perché restituiscono non idee astratte ma esseri più veri del vero. E rende giustizia all’interpretazione di De Capitani: al lavoro esteriore e interiore che ne è la base, alla sua visione da ‘comédien’, senza giudizio. Un lavoro capace di far sentire nel Berlusconi trionfante del 2006, in sintonia con parte del paese, il Berlusconi vecchio di oggi.

  8. El rastre dels més desvalguts entre els papers de l'Hospital de Barcelona

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    Teresa Vinyoles Vidal

    2013-12-01

    Full Text Available Aquest text, que té el seu origen en la ponència que vam presentar al simposi internacional Fonts gràfiques i documentals per a l’estudi històric dels hospitals (abril 2013, pretén oferir un petit mostrari de la informació que es pot extreure i les conclusions que se’n deriven, de la consulta directa de les fonts documentals de l’antic hospital de la Santa Creu de Barcelona. El punt de partida de la nostra recerca s’emmarca en els mateixos orígens històrics d’aquesta centenària institució, és a dir, l’albada del segle XV. En aquest sentit, bàsicament hem fet servir els llibres d’entrades de malalts i d’expòsits, un minutari comptable i uns manuals notarials del quatre-cents i d’èpoques posteriors, conservats a la Biblioteca de Catalunya i a l’Arxiu Històric de la Fundació de l’Hospital de la Santa Creu i Sant Pau. El nostre propòsit no és fer-ne un estat de la qüestió, ni esbossar una història de la pobresa barcelonina, ni tampoc plantejar una visió comparativa de les institucions hospitalàries, senzillament, després de reflexionar sobre el tema, mirarem de dialogar amb les fonts i que siguin elles les que parlin. Procurarem, en el possible, sentir la veu dels pobres del passat, però sense oblidar que la pobresa no és propietat exclusiva dels temps medievals.

  9. Geochemical and palaeontological evidence for the definition of the Silurian/Devonian boundary in the Changwantang Section, Guangxi Province, China

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    Wen-jin Zhao

    2015-02-01

    Full Text Available Southern Guangxi Province is one of the important areas for the study of the Silurian/Devonian boundary (SDB in South China. Despite attempts to define the exact level of the SDB in the Yulin (Guangxi Province area using biostratigraphy, no consensus has been reached as the indicator fossils (e.g. graptolite Monograptus uniformis uniformis, conodont Icriodus woschmidti woschmidti and trilobite Warburgella rugulosa rugosa are not coexistent in South China. Since Mann et al. (2001: Dynamics of the Silurian/Devonian boundary sequence: sedimentary cycles vs. organic matter variation. Terra Nostra, 2001, 44–48 reported the first isotope curve based on organic carbon for the SDB at Klonk in the Czech Republic (GSSP, some comparable variation curves of δ13Corg across the SDB have been obtained at several locations including sections in Turkey and China. This distinct variation curve of the isotopic composition of organic carbon across the SDB provides a chemostratigraphic reference for a worldwide correlation of the SDB. In this study, organic geochemistry together with graptolite biostratigraphy is applied as a tool for identifying the SDB at the Changwantang Section in Yulin (Guangxi Province. The results suggest that the variations in some indexes of organic geochemistry can be correlated to the representative curve of the SDB in the Klonk and Esenyali sections. The exact level of the SDB in the Changwantang Section is positioned within the upper part of the Fangcheng Formation, which is consistent with the available palaeontological data from graptolites (e.g. Colonograptus colonus, Plectograptus sp., Monograptus uniformis, M. cf. M. praehercynicus and M. aequabilis.

  10. Premi letterari e traduzioni (1990-2012: il caso Spagna-Italia

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    Simone Cattaneo

    2013-11-01

    Full Text Available In un contesto globalizzato, in cui l’industria culturale iberica e l’editoria italiana sono state al centro di cambi epocali che le hanno convertite in vasi comunicanti soggetti alle leggi dell’economia mondiale e della società dello spettacolo, può essere utile analizzare come le case editrici della nostra penisola abbiano accolto, negli ultimi vent’anni (dal 1990 al 2012, gli autori e i libri vincitori e finalisti di cinque storici premi letterari spagnoli (il Nadal, il Planeta, il Premio Herralde de Novela, il Nacional de Narrativa e il Nacional de la Crítica poiché, a partire da un quadro d’insieme delle opere tradotte, è possibile, basandosi sulle trame dei volumi e sulle pubblicazioni in lingua italiana che hanno preceduto o seguito la loro stampa, elaborare congetture in merito alle linee guida recentemente adottate da un buon numero di editori nostrani e, al contempo, stilare bilanci riguardo all’impatto della narrativa spagnola nell’attuale mercato librario italiano. In a globalized world, both Spanish and Italian publishing industries have been subjected to radical changes that transformed them into communicating vessels prone to economic laws and dependant on the mechanisms of the society of the spectacle. In such a context, it would be useful to analyse the interest showed in the last twenty years (from 1990 to 2012 by Italian publishing houses towards writers and books distinguished with some of the most notorious Spanish literary awards (Nadal, Planeta, Herralde de Novela, Nacional de Narrativa, Nacional de la Crítica. In this way, starting from a brief abstract of the awarded plots and from an overview of the existing Italian translations of their authors, it would be possible to conjecture some of the recent guidelines followed by Italian publishers and, at the same time, thus would allow us to evaluate the impact of Spanish narrative in our book market.

  11. Information and technology are not enough: we need also knowledge and science.

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    Ferdinando Boero

    2011-09-01

    Full Text Available EnThe era of Information and Technology has changed our life, allowing those who can access an internet connection to consult an almost unlimited number of sites covering almost all topics. It is difficult, however, to distinguish reliable information from unreliable one. The data posted in the web might be very precise while lacking accuracy. It is very important that information is based on solid knowledge, like the one guaranteed by peer-reviewed scientific journals. It is argued, with some examples, that the current policy of Information availability throught the internet is not based on sufficient knowledge. More reliability is available at the sites of scientific journals, but they often require a subscription and enforce copyright restrictions, so hampering the spread of knowledge which is the basis of scientific "publication" (i.e. the delivery of the results of science to the public.ItL'era della Tecnologia dell'Informazione ha cambiato la nostra vita, permettendo a chi abbia una connessione internet di consultare un numero illimitato di siti che coprono quasi tutti gli argomenti. E' difficile, tuttavia, distinguere le informazioni attendibili da quelle inattendibili. I dati pubblicati nella rete possono essere molto precisi ma mancare completamente di accuratezza. E' molto importante che le informazioni siano basate su solide conoscenze, come quella garantita dalla revisione dei pari (peer-review utilizzata dalle riviste scientifiche. Questo lavoro suggerisce, con alcuni esempi, che la politica corrente di disponibilità di informazioni attraverso internet non è basata su sufficiente conoscenza. Una maggiore attendibilità è disponibile sui siti delle riviste scientifiche, ma essi spesso richiedono un abbonamento e impongono restrizioni basate sul copyright, impedendo così la diffusione delle conoscenze che è alla base delle "pubblicazioni" scientifiche (cioè della disponibilità pubblica dei risultati della ricerca scientifica.

  12. Can we use GIS as a historic city's heritage management system? The case study of Hermoupolis-Syros

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    Chatzigrigoriou, Pavlos

    2016-08-01

    Because of the severe economic crisis, Greek historic heritage is in risk. Historic cities as Hermoupolis, were dealing with this risk years before the crisis. The current situation needed drastic action, with innovative low cost ideas. The historic building stock in Hermoupolis counts more than 1.200 buildings. By recording the pathology, the GIS and the D.B.M.S "HERMeS" with the appropriate algorithms identify the historic buildings in risk. In the first application of the system those buildings were 160, with a rate of 2.4 historic buildings collapse every year. The prioritization of interventions in these buildings is critical, as it is not possible to lower the collapsing risk simultaneously in 160 buildings, but neither the interventions can be judged solely by the reactions of local residents. Bearing in mind the fact that one, given the current economic conditions, has to make best use of the funds for this purpose, it is proved that the relevant decision requires multi criteria analysis method of prioritizing interventions. Specifically, the analysis takes into account the risk of collapse of each building, but in connection with a series of other variables, such as the role of building in Hermoupolis, the position in the city, the influence in other areas of interest, the social impact etc. The final result is a catalogue with historic buildings and a point system, which reflects the risk of loosing the building. The point system leads to a Conservation Plan for the city of Hermoupolis, giving the hierarchy of interventions that must be done in order to save the maximum architecture heritage with the minimum funds, postponing the risk of collapsing. In 2015, EU and EUROPA-NOSTRA awarded the above-mentioned project in the category of "Research and Digitization".

  13. Editorial

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    Natàlia Cantó-Milà

    2016-05-01

    Full Text Available Digithum estrena nou número i ho fa amb el primer dels dos que publicarem aquest any. Tal com havíem anunciat en el número anterior, la revista passa de tenir una periodicitat anual a tenir-la semestral. Aquesta novetat ens omple d’alegria, ja que permetrà escurçar a la meitat els temps d’espera per la publicació dels articles i alhora augmentar el nombre de manuscrits publicats anualment. Totes dues són bones notícies. Com ja havíem avançat també, el dossier monogràfic d’enguany es concentra novament en aplicar la perspectiva relacional a un objecte d’estudi concret i aquest cop hem escollit les emocions. Així doncs, com veureu a la introducció del dossier i a cadascun dels articles que s’hi inclouen, comprendre les emocions des d’una perspectiva relacional permet enfocar aspectes que passarien per alt si les cercàvem al cor, al cervell o en algun lloc molt endins de cada individu. La perspectiva relacional no pretén en cap cas eclipsar-ne d’altres, ans complementar-les i fer que la nostra anàlisi del món social en què vivim sigui més rica i fructífera, alhora que esdevingui una eina útil i una perspectiva interessant també per a l’estudi de les emocions.

  14. Revision of Brada Stimpson, 1853, and Bradabyssa Hartman, 1967 (Annelida, Flabelligeridae).

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    Salazar-Vallejo, Sergio I

    2017-11-03

    , 1978) n. comb., B. bransfieldia (Hartman, 1966) n. comb., B. nuda (Annenkova-Chlopina, 1922) n. comb., B. rugosa (Hansen, 1880) n. comb., and B. strelzovi (Jirkov & Filippova in Jirkov, 2001) n. comb. Group verrucosa contains B. abyssalis (Fauchald, 1972) n. comb., B. annenkovae (Buzhinskaja, 2001) n. comb., B. elinae n. sp., B. grangieri n. sp., B. irenaia (Chamberlin, 1919) n. comb., B. levensteinae n. sp., B. mammillata (Grube, 1877) n. comb., B. ochotensis (Annenkova-Chlopina, 1922) n. comb., B. papillata Hartman, 1967, B. tenebricosa (Berkeley, 1966) n. comb., n. status, and B. verrucosa (Chamberlin, 1919) n. comb. Group villosa contains B. capensis (Day, 1961) n. comb., n. status, B. harrisae n. sp., B. hartmanae n. sp., B. ilyvestis (Hartman, 1960) n. comb., B. intoshi (Caullery, 1944) n. comb., B. jirkovi n. sp., B. kirkegaardi n. sp., B. monnioti n. sp., B. parthenopeia (Lo Bianco, 1893) n. comb., B. pilosa (Moore, 1906) n. comb., B. pluribranchiata (Moore, 1923) n. comb., B. setosa (Verrill, 1873) n. comb., B. mezianei n. sp., B. tzetlini (Jirkov & Filippova in Jirkov, 2001) n. comb, B. villosa (Rathke, 1843) n. comb., B. whiteavesi (McIntosh, 1885) n. comb and  B. willeyi n. sp. Keys to aid identification of all genera in Flabelligeridae, to species in Brada, and for the species belonging in the four species groups of Bradabyssa are included.

  15. Fungos micorrízicos vesículo-arbusculares em rizosferas de plantas em dunas do Parque Estadual da Ilha do Cardoso, São Paulo, Brasil: (1 Taxonomia Vesicular-arbuscular mycorrhizal fungi from rhizospheres of dunes plants of Parque Estadual da Ilha do Cardoso, São Paulo State, Brazil (1: taxonomy

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    S. F. B Trufem

    1989-01-01

    Full Text Available De março/1988 a março/1989, mensalmente, foram coletadas o total de 450 amostras de solo de rizosferas de plantas de dunas do Parque Estadual da Ilha do Cardoso, Estado de Sáo Paulo, com a finalidade de se verificar a ocorrência de fungos micorrízicos vesículo-arbusculares (MVA. As plantas mais constantemente investigadas foram: Baccharis trimera DC. (Compositae, Blutaparon portulacoides (St. Hü. Mears (Amaranthaceae, Dalbergia hecastaphylla (L. Taub. (Legurninosae, Hydrocotyle bonariensis Lam. (Umbelliferae,Ipomoeapes-caprae (L.Sweet(Convolvulaceae, Polygaid cyparisseas St. Hül & Moq. (Polygalaceae, além de gramíneas, ciperáceas e outras, que foram coletadas mais esporadicamente. O solo foi tratado pela técnica de decantação e peneiramento em via úmida. Foram verificados 14 taxons de fungos MVA: Acaulospora scrobiculata Trappe, Acaulospora tuberculata Janos & Trappe, Cigaspora gigantea (Nicol. & Gerd. Gerd. & Trappe, Glomus fasciculatum (Thaxter Gerd. & Trappe emend. Walker & Koske, Glomus globiferum Koske & Walker, Glomus monosporum Gerd. & Trappe, Sclerocystis sinuosa Gerd. & Bakshi, Scutellospora calospora (Nicol & Gerd Walker & Sanders, Scutellospora coralloidea (Trappe, Gerd. & Ho (Walker & Sanders, Scutellospora gilmorei (Trappe & Gerd. Walker & Sanders, Scutellospora gregaria (Schenck & Nicol. Walker & Sanders, Scutellospora pérsica (Koske & Walker Walker & Sanders, Scutellospora verrucosa Koske & Walker Walker & Sanders e Scutellospora sp. São apresentadas descrições taxonómicas, comentarios e murônimos dos taxons verificados.Monthly, from March/1988 to March/1989 were collected the total of 450 soil samples from rhizospheres of plants from dunes of Parque Estadual da Ilha do Cardoso, São Paulo State, Brazil, to report the occurrence of VANÍ fungus. The investigated plants were: Baccharis trímera DC. (Compositae, Blutaparon portulacoides (St. Hil. Mears (Amaranthaceae, Dalbergia hecastaphylla (L. Taub

  16. Dongsha Atoll: A potential thermal refuge for reef-building corals in the South China Sea.

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    Tkachenko, Konstantin S; Soong, Keryea

    2017-06-01

    Dongsha Atoll (also known as the Pratas Islands), the northernmost atoll in the South China Sea, experiences two contrasting physical phenomena: repetitive anomalies of the sea surface temperature exceeding the coral bleaching threshold and regular effects of the world's strongest internal waves resulting in the rhythmic upwelling of cold deep waters at the outer reef slopes of the atoll. This unique combination may result in significant differences in coral species composition and structure between the lagoon and forereef. Surveys conducted in August-September 2016 at 12 study sites in the 2-15 m depth range at Dongsha Atoll revealed a clear spatial separation between 'thermally-susceptible' stony coral genera, including Acropora, Pocillopora and Montipora, which mainly inhabited the forereef, and 'thermally-resistant' genera, including massive Porites, foliaceous Echinopora, Pavona and Turbinaria, which mainly resided in the lagoon. The mean coral cover and species richness on the forereef were respectively 1.8 and 1.4 times higher than those in the lagoon (61.3% and 98 species on the forereef vs. 34.2% and 69 species in the lagoon). Coral mortality rates, expressed as the ratio of dead to live stony corals, showed the same pattern (0.4 in the lagoon vs. 0.009 on the forereef). Furthermore, in a laboratory experiment, 'thermally-susceptible' taxa from the lagoon, (e.g. Pocillopora verrucosa and P. damicornis), exhibited higher resistance to bleaching than did their counterparts from the forereef. The present findings indicate that Dongsha Atoll is a potential thermal refuge for reef-building corals in the northern South China Sea and reveal the development of resilience and resistance to bleaching in coral communities of the lagoon. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Diversity and distribution of symbiodinium associated with seven common coral species in the Chagos Archipelago, central Indian Ocean.

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    Sung-Yin Yang

    Full Text Available The Chagos Archipelago designated as a no-take marine protected area in 2010, lying about 500 km south of the Maldives in the Indian Ocean, has a high conservation priority, particularly because of its fast recovery from the ocean-wide massive coral mortality following the 1998 coral bleaching event. The aims of this study were to examine Symbiodinium diversity and distribution associated with scleractinian corals in five atolls of the Chagos Archipelago, spread over 10,000 km(2. Symbiodinium clade diversity in 262 samples of seven common coral species, Acropora muricata, Isopora palifera, Pocillopora damicornis, P. verrucosa, P. eydouxi, Seriatopora hystrix, and Stylophora pistillata were determined using PCR-SSCP of the ribosomal internal transcribed spacer 1 (ITS1, PCR-DDGE of ITS2, and phylogenetic analyses. The results indicated that Symbiodinium in clade C were the dominant symbiont group in the seven coral species. Our analysis revealed types of Symbiodinium clade C specific to coral species. Types C1 and C3 (with C3z and C3i variants were dominant in Acroporidae and C1 and C1c were the dominant types in Pocilloporidae. We also found 2 novel ITS2 types in S. hystrix and 1 novel ITS2 type of Symbiodinium in A. muricata. Some colonies of A. muricata and I. palifera were also associated with Symbiodinium A1. These results suggest that corals in the Chagos Archipelago host different assemblages of Symbiodinium types then their conspecifics from other locations in the Indian Ocean; and that future research will show whether these patterns in Symbiodinium genotypes may be due to local adaptation to specific conditions in the Chagos.

  18. Development of long-term primary cell aggregates from Mediterranean octocorals.

    Science.gov (United States)

    Huete-Stauffer, Carla; Valisano, Laura; Gaino, Elda; Vezzulli, Luigi; Cerrano, Carlo

    2015-09-01

    In lower metazoans, the aggregative properties of dissociated cells leading to in vitro stable multicellular aggregates have furnished a remarkable experimental material to carry out investigations in various research fields. One of the main expectations is to find good models for the study in vitro of the first steps of biomineralization processes. In this study, we examined five common Mediterranean gorgonians (Paramuricea clavata, Corallium rubrum, Eunicella singularis, Eunicella cavolinii, and Eunicella verrucosa) using mechanical cell aggregate production techniques. In particular, we investigated the conditions of aggregate formation, their number and survival in experimental conditions, the DNA synthesizing activity using 5'-bromo-2'-deoxyuridine (BrdU) tests, and the response to calcein addition and observed the secretion of newly formed sclerites. The BrdU tests showed that cell proliferation depends on the size of aggregates and on the presence/absence of symbiotic zooxanthellae. With epifluorescent and confocal imaging from calcein addition assays, we observed the presence of calcium ions within cells, a possible clue for prediction of sclerite formation or calcium deposition. The species-specific efficiency in production of cell aggregates is correlated to the size of polyps, showing that the higher density of polyps and their diameter correspond to higher production of cell aggregates. Regarding the long-term maintenance, we obtained the best results from E. singularis, which formed multicellular aggregates of 0.245 mm ± 0.086 mm in size and maintained symbiotic association with zooxanthellae throughout the experimental run. Formation of sclerites within aggregates opens a wide field of investigation on biomineralization, since de novo sclerites were observed around 30 d after the beginning of the experiment.

  19. Esporotricosis. Valor diagnóstico del cuerpo asteroide

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    Gerzaín Rodríguez Toro

    1985-06-01

    Full Text Available Un hombre de 52 años presentó lesiones costrosas, verrucosas, fisuradas, acordonadas y cicatriciales en la rodilla, pierna y pie izquierdos, de 2 años de evolución, luego de trauma contra un Arbol. Clínicamente se pensó en esporotricosis y cromomicosis. El cultivo mostró un moho negro y el examen directo hifas y esporos pigmentados, por lo cual se diagnóstico cromomicosis. La biopsia no mostró levaduras carmelitas en la inflamación granulomatosa con microabscesos de la dermis, sino cuerpos asteroides esporotricósicos por lo cual se hicieron nuevos cultivos y biopsias. Aquellos revelaron el crecimiento del mismo moho negro y de Sporothrix schenkii. En los múltiples cortes seriados de todas las biopsias se vieron cuerpos asteroides esporotricósicos y nunca se demostraron en la dermis levaduras septadas, pigmentadas tan fáciles de ver en la cromomicosis. En algunos focos se observaron esporos marrones e hifas cortas pigmentadas en las costras. El paciente curó con loduro de Potasio. Pensamos que el moho negro es un saprofito presente únicamente en las costras, originando una contaminación superficial sin repercusión clínica y difícilmente demostrable histopatológicamente, pero muy aparente en el cultivo. Este, en la cromomicosis, debe ir acompañado de biopsia que confirme la presencia de levaduras pigmentadas en la dermis. El cuerpo asteroide de la esporotricosis es específico y característico. Cuando se ve, debe insistirse en el cultivo del hongo, pero si ello no es posible, es indicio suficiente para instaurar el tratamiento específico.

  20. Adjuvant effects of aluminium hydroxide-adsorbed allergens and allergoids – differences in vivo and in vitro

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    Heydenreich, B; Bellinghausen, I; Lund, L; Henmar, H; Lund, G; Adler Würtzen, P; Saloga, J

    2014-01-01

    Allergen-specific immunotherapy (SIT) is a clinically effective therapy for immunoglobulin (Ig)E-mediated allergic diseases. To reduce the risk of IgE-mediated side effects, chemically modified allergoids have been introduced. Furthermore, adsorbance of allergens to aluminium hydroxide (alum) is widely used to enhance the immune response. The mechanisms behind the adjuvant effect of alum are still not completely understood. In the present study we analysed the effects of alum-adsorbed allergens and allergoids on their immunogenicity in vitro and in vivo and their ability to activate basophils of allergic donors. Human monocyte derived dendritic cells (DC) were incubated with native Phleum pratense or Betula verrucosa allergen extract or formaldehyde-or glutaraldehyde-modified allergoids, adsorbed or unadsorbed to alum. After maturation, DC were co-cultivated with autologous CD4+ T cells. Allergenicity was tested by leukotriene and histamine release of human basophils. Finally, in-vivo immunogenicity was analysed by IgG production of immunized mice. T cell proliferation as well as interleukin (IL)-4, IL-13, IL-10 and interferon (IFN)-γ production were strongly decreased using glutaraldehyde-modified allergoids, but did not differ between alum-adsorbed allergens or allergoids and the corresponding unadsorbed preparations. Glutaraldehyde modification also led to a decreased leukotriene and histamine release compared to native allergens, being further decreased by adsorption to alum. In vivo, immunogenicity was reduced for allergoids which could be partly restored by adsorption to alum. Our results suggest that adsorption of native allergens or modified allergoids to alum had no consistent adjuvant effect but led to a reduced allergenicity in vitro, while we observed an adjuvant effect regarding IgG production in vivo. PMID:24528247

  1. Reduced in vitro T-cell responses induced by glutaraldehyde-modified allergen extracts are caused mainly by retarded internalization of dendritic cells.

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    Heydenreich, Bärbel; Bellinghausen, Iris; Lorenz, Steffen; Henmar, Helene; Strand, Dennis; Würtzen, Peter A; Saloga, Joachim

    2012-06-01

    Although allergen-specific immunotherapy is a clinically effective therapy for IgE-mediated allergic diseases, the risk of IgE-mediated adverse effects still exists. For this reason, chemically modified allergoids have been introduced, which may destroy IgE-binding sites while T-cell activation should be retained. The aim of the study was to analyse the differences between intact allergens and differently modified/aggregated allergoids concerning their internalization as well as T-cell and basophil activation. For this purpose human monocyte-derived immature dendritic cells (DC) were incubated with Phleum pratense or Betula verrucosa pollen extract or with the corresponding allergoids, modified with formaldehyde or glutaraldehyde. After an additional maturation process, the antigen-loaded mature DC were co-cultured with autologous CD4(+) T cells. Allergenicity was tested by leukotriene release from basophils. In addition, the uptake of intact allergens and allergoids by immature DC was analysed. The proliferation of, as well as the interleukin-4 (IL-4), IL-10, IL-13 and interferon-γ production by, CD4(+) T cells which had been stimulated with glutaraldehyde allergoid-treated DC was reduced compared with CD4(+) T cells stimulated with intact allergen-treated or formaldehyde allergoid-treated DC. In line with this, glutaraldehyde-modified allergoids were more aggregated and were internalized more slowly. Furthermore, only the allergoids modified with glutaraldehyde induced a decreased leukotriene release by activated basophils. These findings suggest that IgE-reactive epitopes were destroyed more efficiently by modification with glutaraldehyde than with formaldehyde under the conditions chosen for these investigations. Glutaraldehyde-modified allergoids also displayed lower T-cell stimulatory capacity, which is mainly the result of greater modification/aggregation and diminished uptake by DC. © 2012 The Authors. Immunology © 2012 Blackwell Publishing Ltd.

  2. Adjuvant effects of aluminium hydroxide-adsorbed allergens and allergoids - differences in vivo and in vitro.

    Science.gov (United States)

    Heydenreich, B; Bellinghausen, I; Lund, L; Henmar, H; Lund, G; Adler Würtzen, P; Saloga, J

    2014-06-01

    Allergen-specific immunotherapy (SIT) is a clinically effective therapy for immunoglobulin (Ig)E-mediated allergic diseases. To reduce the risk of IgE-mediated side effects, chemically modified allergoids have been introduced. Furthermore, adsorbance of allergens to aluminium hydroxide (alum) is widely used to enhance the immune response. The mechanisms behind the adjuvant effect of alum are still not completely understood. In the present study we analysed the effects of alum-adsorbed allergens and allergoids on their immunogenicity in vitro and in vivo and their ability to activate basophils of allergic donors. Human monocyte derived dendritic cells (DC) were incubated with native Phleum pratense or Betula verrucosa allergen extract or formaldehyde- or glutaraldehyde-modified allergoids, adsorbed or unadsorbed to alum. After maturation, DC were co-cultivated with autologous CD4(+) T cells. Allergenicity was tested by leukotriene and histamine release of human basophils. Finally, in-vivo immunogenicity was analysed by IgG production of immunized mice. T cell proliferation as well as interleukin (IL)-4, IL-13, IL-10 and interferon (IFN)-γ production were strongly decreased using glutaraldehyde-modified allergoids, but did not differ between alum-adsorbed allergens or allergoids and the corresponding unadsorbed preparations. Glutaraldehyde modification also led to a decreased leukotriene and histamine release compared to native allergens, being further decreased by adsorption to alum. In vivo, immunogenicity was reduced for allergoids which could be partly restored by adsorption to alum. Our results suggest that adsorption of native allergens or modified allergoids to alum had no consistent adjuvant effect but led to a reduced allergenicity in vitro, while we observed an adjuvant effect regarding IgG production in vivo. © 2014 British Society for Immunology.

  3. SEAWEED EXTRACTS AS A POTENTIAL TOOL FOR THE ATTENUATION OF OXIDATIVE DAMAGE IN OBESITY-RELATED PATHOLOGIES1.

    Science.gov (United States)

    Lee, Ok-Hwan; Yoon, Kye-Yoon; Kim, Kui-Jin; You, SangGuan; Lee, Boo-Yong

    2011-06-01

    Recent studies suggest that seaweed extracts are a significant source of bioactive compounds comparable to the dietary phytochemicals such as onion and tea extracts. The exploration of natural antioxidants that attenuate oxidative damage is important for developing strategies to treat obesity-related pathologies. The objective of this study was to screen the effects of seaweed extracts of 49 species on adipocyte differentiation and reactive oxygen species (ROS) production during the adipogenesis in 3T3-L1 adipocytes, and to investigate their total phenol contents and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities. Our results show that high total phenol contents were observed in the extracts of Ecklonia cava (see Table 1 for taxonomic authors) (681.1 ± 16.0 μg gallic acid equivalents [GAE] · g -1 ), Dictyopteris undulata (641.3 ± 70.7 μg GAE · g -1 ), and Laurencia intermedia (560.9 ± 48.1 μg GAE · g -1 ). In addition, DPPH radical scavenging activities were markedly higher in Sargassum macrocarpum (60.2%), Polysiphonia morrowii (55.0%), and Ishige okamurae (52.9%) than those of other seaweed extracts (P Gelidium amansii, Gracilaria verrucosa, and Grateloupia lanceolata significantly inhibited adipocyte differentiation and ROS production during differentiation of 3T3-L1 preadipocytes. Furthermore, the production of ROS was positively correlated with lipid accumulation (R 2  = 0.8149). According to these preliminary results, some of the seaweed extracts can inhibit ROS generation, which may protect against oxidative stress that is linked to obesity. Further studies are required to determine the molecular mechanism between the verified seaweeds and ROS, and the resulting effects on obesity. [Table: see text]. © 2011 Phycological Society of America.

  4. Marinagarivorans algicola gen. nov., sp. nov., isolated from marine algae.

    Science.gov (United States)

    Guo, Ling-Yun; Li, Dong-Qi; Sang, Jin; Chen, Guan-Jun; Du, Zong-Jun

    2016-03-01

    Two novel agar-degrading, Gram-stain-negative, motile, heterotrophic, facultatively anaerobic and pale yellow-pigmented bacterial strains, designated Z1 T and JL1, were isolated from marine algae Gelidium amansii (Lamouroux) and Gracilaria verrucosa , respectively. Growth of the isolates was optimal at 28-30 °C, pH 7.0-7.5 and with 2-3 % (w/v) NaCl. Both strains contained Q-8 as the sole respiratory quinone. The major cellular fatty acids in strain Z1 T were C 18 : 1 ω7 c , C 16 : 0 and summed feature 3 (C 16 : 1 ω7 c and/or iso-C 15 : 0 2-OH). The predominant polar lipids in strain Z1 T were phosphatidylethanolamine, phosphatidylglycerol and an aminolipid. The genomic DNA G+C content of both strains was 45.1 mol%. Strains Z1 T and JL1 were closely related, with 99.9 % 16S rRNA gene sequence similarity. The average nucleotide identity (ANI) value between strains Z1 T and JL1 was 99.3 %. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strains Z1 T and JL1 form a distinct phyletic line within the class Gammaproteobacteria , with less than 92.3 % similarity to their closest relatives. Based on data from the current polyphasic study, the isolates are proposed to belong to a novel species of a new genus designated Marinagarivorans algicola gen. nov., sp. nov. The type strain of the type species is Z1 T ( = ATCC BAA-2617 T  = CICC 10859 T ).

  5. Evaluation of laboratory diagnosis for cutaneous tuberculosis

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    Ilhan Afsar

    2016-01-01

    Full Text Available Background and Aim: Cutaneous tuberculosis (CTB is still difficult to diagnose due to its varied clinical presentation and limitations of diagnostic methods. The aim of this study was to evaluate the results of diagnostic laboratory tests available for CTB. Materials and Methods: Twenty-six skin biopsy specimens belonging to clinically suspected cases of CTB were studied retrospectively. The specimens were divided into two portions, one part processed for histopathological evaluation and the other was used for microscopy and inoculation for the isolation of mycobacteria. Polymerase chain reaction (PCR technique was applied to 14 of 26 specimens to detect Mycobacterium tuberculosis complex (MTBC DNA. Results: Of the 26 biopsy specimens, 11 were confirmed as CTB by identification of MTBC in culture and/or histopathologic affirmation. Of these, four were lupus vulgaris, four were TB verrucosa cutis, one was scrofuloderma, one was primary inoculation TB, and one was periorifical CTB. Culture for mycobacteria was positive for five (45.45% specimens, while histopathologic affirmation was obtained in ten (90.90% specimens. Acid-fast Bacilli were not demonstrated in any of the specimens on microscopic examination. The PCR was found to be applied to six of the 11 specimens diagnosed as CTB and was positive in two specimens (33.3%, which were positive for growth in culture and histopathological correlation. Conclusion: The recovery rate of MTBC from biopsy specimens was found to be satisfactory for CTB with histopathological correlation, but the combination of culture with a rapid method, PCR, may improve the diagnostic rate.

  6. Cesium-137 concentrations in marine macroalgae from different biotopes in the Aegean Sea (Greece).

    Science.gov (United States)

    Sawidis, Thomas; Heinrich, Gerorg; Brown, Murray-T

    2003-03-01

    The commonest species of red, brown, and green macroalgae were sampled from a range of biotopes in the Aegean Sea during 1998 for their 137Cs content. Significant differences in 137Cs concentrations were found among different species growing under similar environmental conditions, suggesting that uptake does not follow physical levels but is influenced by allometric parameters and physiological mechanisms. 137Cs content in collected seaweeds were in the descending order: Ulva lactuca>Enteromorpha linza>Gracilaria verrucosa>Ceramium rubrum>Cystoseira barbata. A comparison of the stations studied indicated that the degree of accumulation is also dependent on the geomorphology of the specific area. The west side of Thermaikos Gulf, where the rivers Axios, Aliakmon, and Pinios flow, was highly contaminated as was the Strymonicos Gulf where the river Strymon flows. High cesium concentrations were also observed in algae from Lemnos Island near the mouth of the Dardanelles Channel, most likely due to the horizontal circulation of water masses from the Marmaras Sea to the Aegean Sea resulting in the discharge of 137Cs during the purification process in the Black Sea through the Dardanelles Straits. It is concluded that the general dispersion of 137Cs results from the water circulation regime within the Aegean Sea. Higher levels are present in the northern part of the basin due to current circulation originating from the Black Sea and from outflow of rivers. Levels decrease to the south and east, but increase again to the west of Crete where the Black Sea water mass can be periodically traced.

  7. The unionid (Bivalvia) fauna of the Sipsey River in northwestern Alabama, an aquatic hotspot

    Science.gov (United States)

    McCullagh, W. Henry; Williams, James D.; McGregor, Stuart W.; Pierson, J. Malcom; Lydeard, Charles

    2002-01-01

    Recent surveys for unionid bivalves were conducted in the mainstem of the Sipsey River and headwater tributaries (Tombigbee River drainage) during the summer and autumn of 1996-1999. A total of 35 species and 22 genera were found. Museum records from the upper Sipsey, based largely on the efforts of H. H. Smith during 1910-11, raised the total number of recorded unionids in the Sipsey to 42. Smith documented 25 species in the river; however, most of his collections were made in the mid- to upper-Sipsey, which has lower diversity. The three most common recently observed species in descending order of abundance were Quadrula asperata (I. Lea, 1861), Pleurobema decisum (I. Lea, 1831), and Tritogonia verrucosa (Rafinesque, 1820). Federally listed species observed recently include Lampsilis perovalis (Conrad, 1834) (threatened), Medionidus acutissimus (I. Lea, 1831) (threatened), P. decisum (endangered), P. perovatum (Conrad, 1834) (endangered), and Potamilus inflatus (I. Lea, 1831) (threatened). Species not observed recently but recorded in prior surveys include Anodontoides radiatus (Conrad, 1834), Arcidens confragosus (Say, 1829), Plectomerus dombeyanus (Valenciennes, 1827), Q. metanevra (Rafinesque, 1820), Q. stapes (I. Lea, 1831) (federally endangered), P. taitianum (I. Lea, 1834) (federally endangered), and Toxolasma parvus (Barnes, 1823). Many, species are known recently or historically by only five or fewer recorded specimens including: A. radiatus, Elliptio arctata (Conrad, 1834), Ligumia recta (Lamarck, 1819), P. taitianum, P. inflatus, Q. aspera (Lea, 1831), Q. metanevra, Q. stapes, T. parvus, Truncilla donaciformis (I. Lea, 1828), Uniomerus tetralasmus (Say, 1831), Utterbackia imbecillis (Say, 1829), A. confragosus, and P. dombeyanus. Unlike the mussel fauna of most Alabama streams, that of the Sipsey River is still relatively intact in terms of species richness despite impacts from mining, silvicultural, and agricultural activities. A concerted effort

  8. Genetic and morphological analyses of Gracilaria firma and G. changii (Gracilariaceae, Rhodophyta), the commercially important agarophytes in western Pacific.

    Science.gov (United States)

    Ng, Poh-Kheng; Lin, Showe-Mei; Lim, Phaik-Eem; Hurtado, Anicia Q; Phang, Siew-Moi; Yow, Yoon-Yen; Sun, Zhongmin

    2017-01-01

    Many studies classifying Gracilaria species for the exploitation of agarophytes and the development of the agar industry were conducted before the prevalence of molecular tools, resulting in the description of many species based solely on their morphology. Gracilaria firma and G. changii are among the commercially important agarophytes from the western Pacific; both feature branches with basal constrictions that taper toward acute apices. In this study, we contrasted the morpho-anatomical circumscriptions of the two traditionally described species with molecular data from samples that included representatives of G. changii collected from its type locality. Concerted molecular analyses using the rbcL and cox1 gene sequences, coupled with morphological observations of the collections from the western Pacific, revealed no inherent differences to support the treatment of the two entities as distinct taxa. We propose merging G. changii (a later synonym) into G. firma and recognize G. firma based on thallus branches with abrupt basal constrictions that gradually taper toward acute (or sometimes broken) apices, cystocarps consisting of small gonimoblast cells and inconspicuous multinucleate tubular nutritive cells issuing from gonimoblasts extending into the inner pericarp at the cystocarp floor, as well as deep spermatangial conceptacles of the verrucosa-type. The validation of specimens under different names as a single genetic species is useful to allow communication and knowledge transfer among groups from different fields. This study also revealed considerably low number of haplotypes and nucleotide diversity with apparent phylogeographic patterns for G. firma in the region. Populations from the Philippines and Taiwan were divergent from each other as well as from the populations from Malaysia, Thailand, Singapore and Vietnam. Establishment of baseline data on the genetic diversity of this commercially important agarophyte is relevant in the context of cultivation

  9. Isolation and Identification of Pathogenic Fungi from Thorns and Thistles in Isfahan and Adjacent Cities

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    M Emami

    2007-12-01

    Full Text Available Introduction: The most important subcutaneous fungal infections in man are caused by injury due to contaminated thistles and thorns. From an epidemiological point of view , it is important to recognize the fungi as well as their frequency of them in various thistles and thorns Methods: The present research has been conducted on thorns and thistles of 16 regions including cities and villages of Isfahan province. 800 samples have been collected. Specimens were inoculated and incubated at 25◦C in S & SCC medium. In order to isolate and identify the fungi, cultures in specific media, intraperitoneal injections of mice and disc diffusion test have been applied. Results: Over one year of study, 1676 colonies of actinomycetes and fungi were recognized. The most common fungi were as follows: Alternaria (22/4%,Aspergillus(11/8% , Cladosporium (10/8%,Esteril mycellium(10/6% and Penicillium (9/7%. The prevalence was most in Shahreza city(10/2% , while the least was in Ardestan(3%. The most prevalent yeasts were Candida tropicalis (50% , Rodotrula rubra (12/5% , Candida kerusei(11/4%,Trichosporon candida (7/9% , Unknown yeasts (6/8%, Candida gillermondi (5/7%, Saccharomyces cervisia (3/4%, Geotricum candidum and Trichosporon glabrata (Candida glabrata each one (1/1%. The prevalence was most in Khansar city(19/2%. In this study, 4 species similar to Coccidioides immitis, Phialophora verrucosa (4 species and Exophiala jeanselmei (3 species were identified. Conclusion: In this study done for the first time in this area, pathogenic and opportunistic fungi were isolated. Furthermore, Exophiala jeanselmei and Nocardiopsis dassonvillei were isolated for the first time from thorns in the country.

  10. Arthropods in modern resins reveal if amber accurately recorded forest arthropod communities.

    Science.gov (United States)

    Solórzano Kraemer, Mónica M; Delclòs, Xavier; Clapham, Matthew E; Arillo, Antonio; Peris, David; Jäger, Peter; Stebner, Frauke; Peñalver, Enrique

    2018-05-07

    Amber is an organic multicompound derivative from the polymerization of resin of diverse higher plants. Compared with other modes of fossil preservation, amber records the anatomy of and ecological interactions between ancient soft-bodied organisms with exceptional fidelity. However, it is currently suggested that ambers do not accurately record the composition of arthropod forest paleocommunities, due to crucial taphonomic biases. We evaluated the effects of taphonomic processes on arthropod entrapment by resin from the plant Hymenaea , one of the most important resin-producing trees and a producer of tropical Cenozoic ambers and Anthropocene (or subfossil) resins. We statistically compared natural entrapment by Hymenaea verrucosa tree resin with the ensemble of arthropods trapped by standardized entomological traps around the same tree species. Our results demonstrate that assemblages in resin are more similar to those from sticky traps than from malaise traps, providing an accurate representation of the arthropod fauna living in or near the resiniferous tree, but not of entire arthropod forest communities. Particularly, arthropod groups such as Lepidoptera, Collembola, and some Diptera are underrepresented in resins. However, resin assemblages differed slightly from sticky traps, perhaps because chemical compounds in the resins attract or repel specific insect groups. Ground-dwelling or flying arthropods that use the tree-trunk habitat for feeding or reproduction are also well represented in the resin assemblages, implying that fossil inclusions in amber can reveal fundamental information about biology of the past. These biases have implications for the paleoecological interpretation of the fossil record, principally of Cenozoic amber with angiosperm origin.

  11. Simultaneous detection and identification of Aspergillus and mucorales species in tissues collected from patients with fungal rhinosinusitis.

    Science.gov (United States)

    Zhao, Zuotao; Li, Lili; Wan, Zhe; Chen, Wei; Liu, Honggang; Li, Ruoyu

    2011-04-01

    Rapid detection and differentiation of Aspergillus and Mucorales species in fungal rhinosinusitis diagnosis are desirable, since the clinical management and prognosis associated with the two taxa are fundamentally different. We describe an assay based on a combination of broad-range PCR amplification and reverse line blot hybridization (PCR/RLB) to detect and differentiate the pathogens causing fungal rhinosinusitis, which include five Aspergillus species (A. fumigatus, A. flavus, A. niger, A. terreus, and A. nidulans) and seven Mucorales species (Mucor heimalis, Mucor racemosus, Mucor cercinelloidea, Rhizopus arrhizus, Rhizopus microsporus, Rhizomucor pusillus, and Absidia corymbifera). The assay was validated with 98 well-characterized clinical isolates and 41 clinical tissue specimens. PCR/RLB showed high sensitivity and specificity, with 100% correct identifications of 98 clinical isolates and no cross-hybridization between the species-specific probes. Results for five control isolates, Candida albicans, Fusarium solani, Scedosporium apiospermum, Penicillium marneffei, and Exophiala verrucosa, were negative as judged by PCR/RLB. The analytical sensitivity of PCR/RLB was found to be 1.8 × 10(-3) ng/μl by 10-fold serial dilution of Aspergillus genomic DNA. The assay identified 35 of 41 (85.4%) clinical specimens, exhibiting a higher sensitivity than fungal culture (22 of 41; 53.7%) and direct sequencing (18 of 41; 43.9%). PCR/RLB similarly showed high specificity, with correct identification 16 of 18 specimens detected by internal transcribed spacer (ITS) sequencing and 16 of 22 detected by fungal culture, but it also has the additional advantage of being able to detect mixed infection in a single clinical specimen. The PCR/RLB assay thus provides a rapid and reliable option for laboratory diagnosis of fungal rhinosinusitis.

  12. Simultaneous Detection and Identification of Aspergillus and Mucorales Species in Tissues Collected from Patients with Fungal Rhinosinusitis▿

    Science.gov (United States)

    Zhao, Zuotao; Li, Lili; Wan, Zhe; Chen, Wei; Liu, Honggang; Li, Ruoyu

    2011-01-01

    Rapid detection and differentiation of Aspergillus and Mucorales species in fungal rhinosinusitis diagnosis are desirable, since the clinical management and prognosis associated with the two taxa are fundamentally different. We describe an assay based on a combination of broad-range PCR amplification and reverse line blot hybridization (PCR/RLB) to detect and differentiate the pathogens causing fungal rhinosinusitis, which include five Aspergillus species (A. fumigatus, A. flavus, A. niger, A. terreus, and A. nidulans) and seven Mucorales species (Mucor heimalis, Mucor racemosus, Mucor cercinelloidea, Rhizopus arrhizus, Rhizopus microsporus, Rhizomucor pusillus, and Absidia corymbifera). The assay was validated with 98 well-characterized clinical isolates and 41 clinical tissue specimens. PCR/RLB showed high sensitivity and specificity, with 100% correct identifications of 98 clinical isolates and no cross-hybridization between the species-specific probes. Results for five control isolates, Candida albicans, Fusarium solani, Scedosporium apiospermum, Penicillium marneffei, and Exophiala verrucosa, were negative as judged by PCR/RLB. The analytical sensitivity of PCR/RLB was found to be 1.8 × 10−3 ng/μl by 10-fold serial dilution of Aspergillus genomic DNA. The assay identified 35 of 41 (85.4%) clinical specimens, exhibiting a higher sensitivity than fungal culture (22 of 41; 53.7%) and direct sequencing (18 of 41; 43.9%). PCR/RLB similarly showed high specificity, with correct identification 16 of 18 specimens detected by internal transcribed spacer (ITS) sequencing and 16 of 22 detected by fungal culture, but it also has the additional advantage of being able to detect mixed infection in a single clinical specimen. The PCR/RLB assay thus provides a rapid and reliable option for laboratory diagnosis of fungal rhinosinusitis. PMID:21325541

  13. Mutational epitope analysis of Pru av 1 and Api g 1, the major allergens of cherry (Prunus avium) and celery (Apium graveolens): correlating IgE reactivity with three-dimensional structure.

    Science.gov (United States)

    Neudecker, Philipp; Lehmann, Katrin; Nerkamp, Jörg; Haase, Tanja; Wangorsch, Andrea; Fötisch, Kay; Hoffmann, Silke; Rösch, Paul; Vieths, Stefan; Scheurer, Stephan

    2003-01-01

    Birch pollinosis is often accompanied by adverse reactions to food due to pollen-allergen specific IgE cross-reacting with homologous food allergens. The tertiary structure of Pru av 1, the major cherry (Prunus avium) allergen, for example, is nearly identical with Bet v 1, the major birch (Betula verrucosa) pollen allergen. In order to define cross-reactive IgE epitopes, we generated and analysed mutants of Pru av 1 and Api g 1.0101, the major celery (Apium graveolens) allergen, by immunoblotting, EAST (enzyme allergosorbent test), CD and NMR spectroscopy. The mutation of Glu45 to Trp45 in the P-loop region, a known IgE epitope of Bet v 1, significantly reduced IgE binding to Pru av 1 in a subgroup of cherry-allergic patients. The backbone conformation of Pru av 1 wild-type is conserved in the three-dimensional structure of Pru av 1 Trp45, demonstrating that the side chain of Glu45 is involved in a cross-reactive IgE epitope. Accordingly, for a subgroup of celery-allergic patients, IgE binding to the homologous celery allergen Api g 1.0101 was enhanced by the mutation of Lys44 to Glu. The almost complete loss of IgE reactivity to the Pru av 1 Pro112 mutant is due to disruption of its tertiary structure. Neither the mutation Ala112 nor deletion of the C-terminal residues 155-159 influenced IgE binding to Pru av 1. In conclusion, the structure of the P-loop partially explains the cross-reactivity pattern, and modulation of IgE-binding by site-directed mutagenesis is a promising approach to develop hypo-allergenic variants for patient-tailored specific immunotherapy. PMID:12943529

  14. MIO-PLIOCENE CRUSTACEANS FROM THE CANARY ISLANDS, SPAIN

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    JUAN FRANCISCO BETANCORT

    2014-11-01

    Full Text Available There are few previous references to fossil crustaceans for the Neogene marine layers of the Canary Islands (Spain. The Mio-Pliocene marine sedimentary layers in the eastern islands (Gran Canaria, Fuerteventura and Lanzarote were previously characterised by the presence of numerous fossil fauna, mainly anthozoans and molluscs, which correspond to an equatorial-typepalaeoclimate, warmer than the present climate. This Mio-Pliocene transition dated between 9.3 and 4.1 Ma. In this paper, 12 fossil crustacean taxa are identified and classified, including decapods and barnacles: Balanus concavus Bronn, 1831, Balanus spongicola Brown, 1827, Balanus perforatus Bruguière, 1789, Chenolobia testudinaria Linnè, 1767, Tetraclita cf. rubescens Darwin, 1854, Callianassa matsoni Rathbun, 1935, Callianassa sp., Upogebia sp, Eriphia aff. verrucosa (Forskal, 1775 , Maja sp., Scylla michelini Milne-Edwards, 1861 and Ocypode sp. Some of these taxa mean new references for the Atlantic islands and the North African Atlantic and definitely enlarge the palaeographic distribution of Neogene crustaceans beyond the Mediterranean region, extending it to the North Atlantic. Particularly significant are the presence of Tetraclita cf. rubescens ,this being the first reported fossil occurrence of this barnacle outside the North America Pacific coasts, and Chenolobia testudinaria , indicating for the first time the existence of marine turtles in these islands during the Neogene. These results are coherent with previous research hypothesising the existence of a flow of surface water between the Pacific and Atlantic in the Mio-Pliocene transition (Central American Seaway, CAS which explains the arrival of organisms, in larval stage, from Central America to the Canary Islands.

  15. Tratamento cirúrgico e terapias adjuvantes na papilomatose respiratória

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    Melissa Ameloti Gomes Avelino

    2013-10-01

    Full Text Available Papilomatose respiratória recorrente ou papilomatose laríngea recorrente é uma doença da laringe, causada pelo papiloma vírus humano, caracterizada por lesões epiteliais verrucosas e, geralmente, recorrentes. Na literatura são descritos diversos tipos de tratamento, como cirurgia a frio, a laser e/ou uso de microdebridador, além das terapias adjuvantes; todas no sentindo de diminuir possíveis sequelas permanentes da doença. OBJETIVO: Realizar uma revisão de literatura a respeito desta doença com ênfase nas técnicas cirúrgicas e terapias adjuvantes mais utilizadas atualmente. MÉTODO: Utilizou-se a metodologia de revisão bibliográfica, por meio de levantamentos em base de dados eletrônicos de domínio público, entre 1992-2012, utilizando-se as palavras-chave: papiloma, infecções por papillomavírus, laringe, terapêutica, vacinas contra papillomavírus. RESULTADOS: Foram levantados 357 artigos, dos quais 49 foram usados como base para esta revisão. Os trabalhos científicos apontam para a redução de recidiva na maioria das terapêuticas adjuvantes. Entretanto, o levantamento demonstrou metodologias e amostras diferentes, o que não permitiu comparar os tipos de tratamento e de terapias adjuvantes. CONCLUSÃO: A escolha da técnica cirúrgica varia entre os autores, porém, há uma tendência atual ao uso do microdebridador. As terapias adjuvantes recentes, como cidofovir, vacina tetravalente contra o papiloma vírus humano e bevacizumab, necessitam de estudos mais amplos.

  16. Evaluation of anti-ulcerogenic activity in an Aqueous Extract obtained from Bauhinia forficata leaves

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    Giovanna Christina Costa Mazzeo

    2015-09-01

    Full Text Available Bauhinia forficata Link, popularly known as pata-de-vaca, unha-de-vaca, casco-de-vaca, has been widely used in traditional medicine to treat several diseases. Leaves of B. forficata are used in popular medicine as a diuretic, hypoglycemic, tonic and cleanser, and to combat elephantiasis. However, despite the wide range of ethnopharmacological data surrounding the plant, there are no scientific data demonstrating a probable anti-ulcerogenic activity conferred by use of that species. The present study aimed to evaluate the antiulcer properties of an infusion of fresh leaves of B. forficata Link. From the leaves of B. forficata, an Aqueous extract (AqE was obtained and the phytochemical analysis showed the presence of flavonols in this extract. In the gastric ulcer induced by administration of HCl-Ethanol model performed with four different doses of AqE (125, 250, 500 and 1000 mg.Kg-1, the AqE showed significant preventive activity (*p<0.01 at doses of 1000 mg.Kg-1. The antiulcer activity of AqE (1000 mg.Kg-1 could also be demonstrated in experimental models of NSAID-bethanechol (**p<0.001 and absolute ethanol (**p<0.001. Moreover, AqE (1000 mg.Kg-1 promoted a significant increase (**p<0.001 in the amount of gastric mucus. The data presented here demonstrated the potential gastroprotective activity from AqE, possibly attributed to the presence of flavonols in this extract. These results may serve as a support for the development of new treatments related to the pathology of gastric ulcer.Keywords: Gastric ulcer. Cytoprotection. Flavonoids. Bauhinia forficata.  

  17. Technetium-99m-Labeled Diethylcarbamazine Citrate (99mTc-DEC as a New Diagnostic Agent for Lymphatic Filariasis Detection

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    N. K. Oekar

    2017-11-01

    Full Text Available Lymphatic filariasis or more commonly known as elephantiasis disease has infected more than 120 million people in 80 countries; and more than 40 million of them are unable to work, in addition to disruption of aesthetic values. The problem faced by almost all people in combating this infectious disease is delayed diagnosis. The sufferers do not realize that they have been infected with this disease. A specific and accurate method of early detection is therefore needed. 99mTc-labeled Diethylcarbamazine-citrate (99mTc-DEC has been successfully prepared. However, as part of the discovery and development of new drugs, the fulfillment of pharmaceutical and safety requirements have to be evaluated. Physico-chemical aspects such as stability, purity levels, and other pharmaceutical requirements, as well as pharmacokinetic studies and route of administration, are important parameters to be studied. The stability test showed that after seven months of storage, a preparation in a dry kit retains an efficiency of labeling and a purity level of more than 90 % and its physico-chemical and biological characteristics remained steady. Biodistribution test in Wistar rat showed that the greatest accumulation occurred in the lymphatic system, especially in the popliteal glands and in lumbar and mesenteric lymph nodes. Imaging with a gamma camera after intradermal and intravenous injections to the experimental animals resulted in a positive image that showed 99mTc-DEC accumulation in the target organ. The results of this innovation are expected to contribute significantly to improving public health, particulary in early detection of filarial infections. In addition, this result is expected to be a concrete contribution to the program of "The Global Goal of Elimination of Lymphatic Filariasis as a Public Health Problem by the Year 2020”.

  18. Addressing the neglected tropical disease podoconiosis in Northern Ethiopia: lessons learned from a new community podoconiosis program.

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    Sara Tomczyk

    Full Text Available BACKGROUND: Despite its great public health importance, few control initiatives addressing podoconiosis (non-filarial elephantiasis, a geochemical neglected tropical disease exist. In June 2010, the first podoconiosis program in Northern Ethiopia, consisting of prevention, awareness, and care and support activities, began in Debre Markos, Northern Ethiopia. This study aims to document and disseminate the lessons learned from a new community podoconiosis program in Debre Markos. METHODS/PRINCIPAL FINDINGS: We used a content analysis approach to examine and evaluate data from a series of sources. These sources include conducted interview transcripts, a focus group discussion transcript and secondary sources including monitoring and evaluation field reports, observation notes, and research obtained from a literature review. Themes were identified and grouped into matrix tables. Overall, sixteen program steps were identified and grouped into 6 domains: Initial preparation, training and sensitization, foundation building, treatment activity implementation, awareness, and follow-up. Emphasis is placed on the need for baseline data, effective training, local leadership, experience-sharing, mass-awareness, cross-cutting sector issues (i.e., water and waste management, and integration with government health systems. Related successes and challenges are also described, as are stakeholder roles and misconceptions and socio-cultural challenges affecting the program start-up. Many of the identified successes and challenges are relevant to the aim of the podoconiosis program to be sustainable and community-led. CONCLUSIONS/SIGNIFICANCE: Much of this information has already been used to improve the Debre Markos program. We also anticipate that the domains and steps identified will be useful in guiding new programs in other settings where podoconiosis is highly prevalent. We hope to encourage partnerships and collaboration among podoconiosis stakeholders in

  19. Haemolytic activity of soil from areas of varying podoconiosis endemicity in Ethiopia.

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    Jennifer S Le Blond

    Full Text Available Podoconiosis, non-filarial elephantiasis, is a non-infectious disease found in tropical regions such as Ethiopia, localized in highland areas with volcanic soils cultivated by barefoot subsistence farmers. It is thought that soil particles can pass through the soles of the feet and taken up by the lymphatic system, leading to the characteristic chronic oedema of the lower legs that becomes disfiguring and disabling over time.The close association of the disease with volcanic soils led us to investigate the characteristics of soil samples in an endemic area in Ethiopia to identify the potential causal constituents. We used the in vitro haemolysis assay and compared haemolytic activity (HA with soil samples collected in a non-endemic region of the same area in Ethiopia. We included soil samples that had been previously characterized, in addition we present other data describing the characteristics of the soil and include pure phase mineral standards as comparisons.The bulk chemical composition of the soils were statistically significantly different between the podoconiosis-endemic and non-endemic areas, with the exception of CaO and Cr. Likewise, the soil mineralogy was statistically significant for iron oxide, feldspars, mica and chlorite. Smectite and kaolinite clays were widely present and elicited a strong HA, as did quartz, in comparison to other mineral phases tested, although no strong difference was found in HA between soils from the two areas. The relationship was further investigated with principle component analysis (PCA, which showed that a combination of an increase in Y, Zr and Al2O3, and a concurrent increase Fe2O3, TiO2, MnO and Ba in the soils increased HA.The mineralogy and chemistry of the soils influenced the HA, although the interplay between the components is complex. Further research should consider the variable biopersistance, hygroscopicity and hardness of the minerals and further characterize the nano-scale particles.

  20. Tailoring consent to context: designing an appropriate consent process for a biomedical study in a low income setting.

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    Fasil Tekola

    2009-07-01

    Full Text Available Currently there is increasing recognition of the need for research in developing countries where disease burden is high. Understanding the role of local factors is important for undertaking ethical research in developing countries. We explored factors relating to information and communication during the process of informed consent, and the approach that should be followed for gaining consent. The study was conducted prior to a family-based genetic study among people with podoconiosis (non-filarial elephantiasis in southern Ethiopia.We adapted a method of rapid assessment validated in The Gambia. The methodology was entirely qualitative, involving focus-group discussions and in-depth interviews. Discussions were conducted with podoconiosis patients and non-patients in the community, fieldworkers, researchers, staff of the local non-governmental organisation (NGO working on prevention and treatment of podoconiosis, and community leaders. We found that the extent of use of everyday language, the degree to which expectations of potential participants were addressed, and the techniques of presentation of information had considerable impact on comprehension of information provided about research. Approaching podoconiosis patients via locally trusted individuals and preceding individual consent with community sensitization were considered the optimal means of communication. Prevailing poverty among podoconiosis patients, the absence of alternative treatment facilities, and participants' trust in the local NGO were identified as potential barriers for obtaining genuine informed consent.Researchers should evaluate the effectiveness of consent processes in providing appropriate information in a comprehensible manner and in supporting voluntary decision-making on a study-by-study basis.

  1. Sebaran Nyamuk Vektor Di Kabupaten Muaro Jambi, Provinsi Jambi

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    Yanelza Supranelfy

    2017-02-01

    Full Text Available AbstractMosquito-borne disease still a public health problem, both in urban and rural areas, such as: dengue hemorrhagic fever (DHF, malaria, lymphatic filariasis (elephantiasis, chikungunya and japanese encephalitis. Muaro Jambi is one of regencies in Jambi Province were found to vector borne diseases. The aim of this study is to get more information about the mosquito diversity in Muaro Jambi Regency for comprehensive data. The activities carried out are catching mosquitoes at night using human landing and resting collection methods. There were a total of 1.722 mosquitoes of four genera were collected (Aedes, Anopheles, Culex and Mansonia that consists of 24 species. The results of this study give additional information on the diversity of mosquitoes found in Muaro Jambi Regency.Keywords: Mosquito, vector, Muaro Jambi RegencyAbstrakPenyakit yang ditularkan oleh nyamuk masih merupakan masalah kesehatan bagi masyarakat, baik di perkotaan maupun di pedesaan, seperti demam berdarah dengue (DBD, malaria, filariasis (kaki gajah, chikungunya dan japanese encephalitis. Muaro Jambi merupakan salah satu kabupaten di Provinsi Jambi yang ditemukan beberapa penyakit tular vektor. Tujuan penelitian ini adalah untuk menambah informasi mengenai fauna nyamuk di Kabupaten Muaro Jambi untuk mendapatkan data yang komprehensif. Kegiatan yang dilakukan yaitu penangkapan nyamuk pada malam hari dengan metode human landing collection dan nyamuk istirahat (resting collection. Sebanyak 1.722 ekor nyamuk berhasil diangkap yang terdiri dari empat genera (Aedes, Anopheles, Culex dan Mansonia meliputi 24 spesies. Hasil penelitian ini diharapkan dapat memberikan tambahan informasi mengenai keragaman nyamuk yang ditemukan di Kabupaten Muaro Jambi.Kata Kunci: Nyamuk, vektor, Kabupaten Muaro Jambi

  2. An integrated in vitro imaging platform for characterizing filarial parasite behavior within a multicellular microenvironment.

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    Timothy Kassis

    2014-11-01

    Full Text Available Lymphatic Filariasis, a Neglected Tropical Disease, is caused by thread-like parasitic worms, including B. malayi, which migrate to the human lymphatic system following transmission. The parasites reside in collecting lymphatic vessels and lymph nodes for years, often resulting in lymphedema, elephantiasis or hydrocele. The mechanisms driving worm migration and retention within the lymphatics are currently unknown. We have developed an integrated in vitro imaging platform capable of quantifying B. malayi migration and behavior in a multicellular microenvironment relevant to the initial site of worm injection by incorporating the worm in a Polydimethylsiloxane (PDMS microchannel in the presence of human dermal lymphatic endothelial cells (LECs and human dermal fibroblasts (HDFs. The platform utilizes a motorized controllable microscope with CO2 and temperature regulation to allow for worm tracking experiments with high resolution over large length and time scales. Using post-acquisition algorithms, we quantified four parameters: 1 speed, 2 thrashing intensity, 3 percentage of time spent in a given cell region and 4 persistence ratio. We demonstrated the utility of our system by quantifying these parameters for L3 B. malayi in the presence of LECs and HDFs. Speed and thrashing increased in the presence of both cell types and were altered within minutes upon exposure to the anthelmintic drug, tetramisole. The worms displayed no targeted migration towards either cell type for the time course of this study (3 hours. When cells were not present in the chamber, worm thrashing correlated directly with worm speed. However, this correlation was lost in the presence of cells. The described platform provides the ability to further study B. malayi migration and behavior.

  3. Haemolytic activity of soil from areas of varying podoconiosis endemicity in Ethiopia

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    Le Blond, Jennifer S.; Baxter, Peter J.; Bello, Dhimiter; Raftis, Jennifer; Molla, Yordanos B.; Cuadros, Javier; Davey, Gail

    2017-01-01

    Background Podoconiosis, non-filarial elephantiasis, is a non-infectious disease found in tropical regions such as Ethiopia, localized in highland areas with volcanic soils cultivated by barefoot subsistence farmers. It is thought that soil particles can pass through the soles of the feet and taken up by the lymphatic system, leading to the characteristic chronic oedema of the lower legs that becomes disfiguring and disabling over time. Methods The close association of the disease with volcanic soils led us to investigate the characteristics of soil samples in an endemic area in Ethiopia to identify the potential causal constituents. We used the in vitro haemolysis assay and compared haemolytic activity (HA) with soil samples collected in a non-endemic region of the same area in Ethiopia. We included soil samples that had been previously characterized, in addition we present other data describing the characteristics of the soil and include pure phase mineral standards as comparisons. Results The bulk chemical composition of the soils were statistically significantly different between the podoconiosis-endemic and non-endemic areas, with the exception of CaO and Cr. Likewise, the soil mineralogy was statistically significant for iron oxide, feldspars, mica and chlorite. Smectite and kaolinite clays were widely present and elicited a strong HA, as did quartz, in comparison to other mineral phases tested, although no strong difference was found in HA between soils from the two areas. The relationship was further investigated with principle component analysis (PCA), which showed that a combination of an increase in Y, Zr and Al2O3, and a concurrent increase Fe2O3, TiO2, MnO and Ba in the soils increased HA. Conclusion The mineralogy and chemistry of the soils influenced the HA, although the interplay between the components is complex. Further research should consider the variable biopersistance, hygroscopicity and hardness of the minerals and further characterize the

  4. Addressing the Neglected Tropical Disease Podoconiosis in Northern Ethiopia: Lessons Learned from a New Community Podoconiosis Program

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    Tomczyk, Sara; Tamiru, Abreham; Davey, Gail

    2012-01-01

    Background Despite its great public health importance, few control initiatives addressing podoconiosis (non-filarial elephantiasis, a geochemical neglected tropical disease) exist. In June 2010, the first podoconiosis program in Northern Ethiopia, consisting of prevention, awareness, and care and support activities, began in Debre Markos, Northern Ethiopia. This study aims to document and disseminate the lessons learned from a new community podoconiosis program in Debre Markos. Methods/Principal Findings We used a content analysis approach to examine and evaluate data from a series of sources. These sources include conducted interview transcripts, a focus group discussion transcript and secondary sources including monitoring and evaluation field reports, observation notes, and research obtained from a literature review. Themes were identified and grouped into matrix tables. Overall, sixteen program steps were identified and grouped into 6 domains: Initial preparation, training and sensitization, foundation building, treatment activity implementation, awareness, and follow-up. Emphasis is placed on the need for baseline data, effective training, local leadership, experience-sharing, mass-awareness, cross-cutting sector issues (i.e., water and waste management), and integration with government health systems. Related successes and challenges are also described, as are stakeholder roles and misconceptions and socio-cultural challenges affecting the program start-up. Many of the identified successes and challenges are relevant to the aim of the podoconiosis program to be sustainable and community-led. Conclusions/Significance Much of this information has already been used to improve the Debre Markos program. We also anticipate that the domains and steps identified will be useful in guiding new programs in other settings where podoconiosis is highly prevalent. We hope to encourage partnerships and collaboration among podoconiosis stakeholders in future growth and

  5. Podoconiosis patients’ willingness to pay for treatment services in Northwest Ethiopia: potential for cost recovery

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    2014-01-01

    Background Podoconiosis is non-filarial elephantiasis of the lower legs. It is more commonly found in tropical Africa, Central and South America, and northwest India. In Ethiopia, a few non-governmental organizations provide free treatment to podoconiosis patients, but sustainability of free treatment and scale-up of services to reach the huge unmet need is challenged by resource limitations. We aimed to determine podoconiosis patient’s willingness to pay (WTP) for a treatment package (composed of deep cleaning of limbs with diluted antiseptic solution, soap, and water, bandaging, application of emollient on the skin, and provision of shoes), and factors associated with WTP in northwestern Ethiopia. Methods A cross-sectional study was conducted among randomly selected untreated podoconiosis patients (n = 393) in Baso Liben woreda, northwestern Ethiopia. The contingent valuation method was used with a pre-tested interviewer-administered questionnaire. Results The majority of podoconiosis patients (72.8%) were willing to pay for treatment services. The median WTP amount was 64 Birr (US$ 3.28) per person per year. More than one-third of patients (36.7%) were willing to pay at least half of the full treatment cost and 76.2% were willing to pay at least half of the cost of shoes. A multivariate analysis showed that having a higher monthly income, being a woman, older age, being aware of the role of shoes to prevent podoconiosis, and possession of a functional radio were significantly associated with higher odds of WTP. Conclusions The considerable WTP estimates showed that podoconiosis treatment could improve sustainability and service utilization. A subsidized cost recovery scheme could reduce treatment costs and more feasibility integrate podoconiosis treatment service with other NTDs and the government’s primary health care system. PMID:24642085

  6. Evaluation of the recombinant antigens Wb14 and WbT for the capture antibody diagnosis of lymphatic filariasis

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    André Filipe Pastor

    2018-03-01

    Full Text Available BACKGROUND Lymphatic filariasis (LF is a parasitic disease caused mainly by the Wuchereria bancrofti worm and that affects up to 120 million people worldwide. LF is the second cause of chronic global deformity, responsible for 15 million people with lymphedema (elephantiasis and 25 million men with scrotal hydrocele. Its diagnosis is still associated with numerous difficulties, such as the sample collection periods (microfilaria nocturnal periodicity and limited diagnostic kits. OBJECTIVES The aim of this work was to evaluate two recombinant antigens (Wb14 and WbT as part of an enzyme-linked immunosorbent assay (ELISA based antibody capture tests for LF. METHODS The recombinant antigens rWb14 and rWbT were expressed in Escherichia coli BL21 and an antibody capture ELISA was performed. For this, sera were used from microfilaremic individuals with W. bancrofti (MF, chronic pathology (CP, individuals infected with Strongyloides (SP and healthy controls from endemic (EN and non-endemic (NE areas. FINDINGS Both tests showed similar results, with 90% sensitivity and 96.6% specificity. In comparison with the BM14 ELISA commercial test, the Wb14 and WbT antigens performed with identical sensitivity but greater specificity. Reduced positivity with the CP suggested a potential to monitor cure. This was not confirmed, however, when sera from individuals up to seven years after treatment were assayed. MAIN CONCLUSIONS The Wb14 and WbT ELISAs were considered efficient and promising diagnostic tests. Due to the importance of antibody capture analysis to evaluate the Global Program to Eliminate Lymphatic Filariasis (GPELF, the tests proposed here appear as great alternatives to the available commercial system.

  7. FAKTOR-FAKTOR YANG MEMPENGARUHI KEJADIAN FILARIASIS DI INDONESIA (DATA RISKESDAS 2007

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    Mardiana Mardiana

    2012-11-01

    Full Text Available Filariasis or elephantiasis diseases which caused by filaria worm and contagious through mosquito bite, still the major community health problem in Indonesia. There are several type of filaria worm in Indonesia, i.e. Wuchereria bancrofti, Brugia malayi and Brugia timori. The vectors of filariasis are Culex quinquefasciatus in the urban area, Anopheles spp, Aedes spp and Mansonia spp in the rural area. The infection risk in some area of filariasis related to the situation of local area. Various factor of environmental area which area physical, biological and also cultural social to be influence to development of transmitted filariasis by mosquito. The analysis of data Riskesdas 2007 has been done to perform of factor influence filariasis case in Indonesia. Same parameters was analyzed to case of filariasis in last 12 months; gender, ages, educations, work, mosquito net usage, sources of water, effluent dismissal, residences, water dismissal channel, existence of livestock in house. From analysis inferential, show there is no relation between genders, age, education, work, and mosquito net usage, sources of water, water dismissal channel, and existence of livestock in house to case filariasis. Statistically indicates that there is significantly difference between residences in rural and in urban to case of filariasis in last 12 months. Responder who live in rural areas (0,05% have 2,4 times risk higher than responder who live in urban (0,03%. The same as condition of water dismissal channel shows to existence of significantly differences. Responder who have water dismissal channel without cover have high risk infections of filariasis in the last 12 months were 0,05%, while the responder have water dismissal channel with cover have high risk in last 12 months were 0,03%. Keywords: Filariasis, endemic area, factors

  8. ANTIGENAEMIA AS AN INDICATOR OF FILARIAL ENDEMICITY

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    F. Partono

    2012-09-01

    Full Text Available This is a report of 1 -year evaluation of chemotherapeutic intervention in an area of Indonesia endemic for lymphatic filariasis. Control measures were initiated in 1977 by parasite control, informal health educa­tion, and community participation at the village level, well in accord with the WHO-concept of health for all. Diethylcarbamazine (DEC was mass distributed in 1977 and 1988, and selectively distributed in 1978, 1979, 1981, and 1982 to those who were micro-filaraemic prior to DEC treatments, those with a history of adenoly mphangitis over the previous one year period, and to all new comers. In addition, each villager with acute symptoms of adenolymphangitis was immediately treated with a single course of 300 mg DEC for 10 days. No intervention measures were taken between 1982 to 1988, and no attempt was taken to control the vector or to restrict movement between controlled and uncontrolled areas during the whole studies. With these measures, the microfilaria (mf rate decreased from 30% to 0%, the adenolymphangitis rate from 46% to 11%, and the elephantiasis rate from 35% to 3%. The abatement of acute and chronic filarial symptoms over the study period and the disappearance of microfilaremia in the community are pointing towards the possibility of eradicating the partasite from the community. To test this hypothesis, serum samples were tested for circulating filarial antigen by a two-site antigen capture assay employing anti-phosphorylcholine monoclonal antibodies. There was a sharp fall in circulating antigenaemia, demonstrating that infection has either been eliminated from nearly all villagers, or that intensity of infection is now undetectably low. We feel that antigenaemia can be used as an indicator of filarial endemicity.

  9. Patients’ perceptions of podoconiosis causes, prevention and consequences in East and West Gojam, Northern Ethiopia

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    Molla Yordanos B

    2012-09-01

    Full Text Available Abstract Background Podoconiosis is a form of non-filarial elephantiasis that affects barefoot individuals in highland tropical areas. The disease presents with bilateral, asymmetric swelling of the legs, usually confined to below the knee. This study aimed to assess podoconiosis patients’ perceptions of prevention, control, causes and familial clustering of the disease, and to document physical, social and economic impairments associated with the disease, with the ultimate aim of enabling development of tailored interventions in this region. Methods This descriptive study is part of the largest cross-sectional community-based household survey yet conducted on podoconiosis. It was completed in November and December, 2011, in Debre Eliyas and Dembecha Woredas of East and West Gojam Zones, northern Ethiopia, and consisted of a house-to-house census by community health workers followed by interviews of identified patients using a structured questionnaire. Results In the 17,553 households surveyed, 1,319 patients were identified. More male as compared to female patients were married (84.6% vs. 53.6%, χ2 = 157.1, p 2 = 102.3, p  Conclusion This study shows that podoconiosis has strong psychosocial, physical and economic impacts on patients in East and West Gojam Zones of northern Ethiopia. Concerns related to familial clustering, poor understanding of the causes and prevention of podoconiosis all add to the physical burden imposed by the disease. Strategies that may ease the impact of podoconiosis include delivery of tailored health education on the causes and prevention of disease, involving patients in intervention activities, and development of alternative income-generating activities for treated patients.

  10. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis.

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    Christina A Bulman

    2015-02-01

    Full Text Available Two major human diseases caused by filariid nematodes are onchocerciasis, or river blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin, diethylcarbamazine (DEC, and albendazole are used in control programs for these diseases, but are mainly effective against the microfilarial stage and have minimal or no effect on adult worms. Adult Onchocerca volvulus and Brugia malayi worms (macrofilariae can live for up to 15 years, reproducing and allowing the infection to persist in a population. Therefore, to support control or elimination of these two diseases, effective macrofilaricidal drugs are necessary, in addition to current drugs. In an effort to identify macrofilaricidal drugs, we screened an FDA-approved library with adult worms of Brugia spp. and Onchocerca ochengi, third-stage larvae (L3s of Onchocerca volvulus, and the microfilariae of both O. ochengi and Loa loa. We found that auranofin, a gold-containing drug used for rheumatoid arthritis, was effective in vitro in killing both Brugia spp. and O. ochengi adult worms and in inhibiting the molting of L3s of O. volvulus with IC50 values in the low micromolar to nanomolar range. Auranofin had an approximately 43-fold higher IC50 against the microfilariae of L. loa compared with the IC50 for adult female O. ochengi, which may be beneficial if used in areas where Onchocerca and Brugia are co-endemic with L. loa, to prevent severe adverse reactions to the drug-induced death of L. loa microfilariae. Further testing indicated that auranofin is also effective in reducing Brugia adult worm burden in infected gerbils and that auranofin may be targeting the thioredoxin reductase in this nematode.

  11. Elementi di Icnografia mediterranea (Protonuraghi a camera naviforme

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    Manca Demurtas, Lucia

    1991-12-01

    Full Text Available Not available

    Definimos como protonuraghi con cámara «naviforme» aquellos nuraghi caracterizados por un corredor o espacio principal que, por ampliación de las paredes laterales, se transforma en cámara Esta presenta la parte posterior en forma de ábside semicircular y la cubierta en ojiva. El tipo, ya examinado por nosotros en el ámbito de un análisis general, aunque preliminar, sobre los protonuraghi, parece, por el momento, preludiar. en una propuesta de evolución arquitectónica, al nuraghe en tholos. Nuestro análisis no intenta fijar los puntos cronológicos en el interior del paso evolutivo aunque parece presumible que la creación y la difusión de este tipo de monumento pueda encuadrarse entre el Bronce antiguo y el Bronce medio teniendo en cuenta también los datos materiales adquiridos hasta ahora. Aunque sin infravalorar un posible aporte externo en la definición del tholos, parece igualmente evidente que la aceptación de tal modelo arquitectónico no pudo ser tan contrastante con la experiencia ya adquirida. [it] Definiamo protonuraghi con camera «naviforme» quei nuraghi il cui elemento caratterizzante è il corridoio o spazio principale che per l'ampliamento delle pareti laterali si muta in camera. Essa presenta la parte posteriore in forma di abside semicircolare e la copertura ad ogiva . II tipo, da noi giii preso in esame nell'ambito di un'analisi generale, seppure preliminare, sui protonuraghi, sembrerebbe, al momento, preludere, in una proposta di evoluzione architettonica, al nuraghe a tholos. La nostra analisi esula dall'intento di fissare dei punti cronologici all'interno del passaggio evolutivo anche se appare presumibile che la creazione e la diffusione di questo tipo di monumento possa inquadrarsi tra il Bronzo antieo e il Bronzo medio tenendo conto anche dei dati materiali fin' ora acquisiti. Anche non sottovalutando un possibile apporto estemo nel definirsi della

  12. Zones d’invisibilitat que emergeixen de les relacions pedagogiques. Compartint penumbres entre estudiants i docents

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    Fernando Herraiz-García

    2015-07-01

    Full Text Available Els docents que formem part del grup d’innovació Indaga-t (GIDCUB-13/087 compartim dilemes en torn a la nostra pràctica docent. El lloc crític que ocupem (lloc de no-saber i/o de voler saber més ens porta a reflexionar sobre les relacions pedagògiques emergents als diferents espais on intervenim. El projecte Zones d’invisibilitat a l’avaluació formativa de l’aprenentatge autònom (2013PID-UB/001 ens ha portat a explorar les inquietuds que hem experimentat com a docents i a posar-les en relació amb aquelles preocupacions que els i les estudiants diuen haver viscut a les nostres assignatures. Treballar en aquesta línia, va comportar definir les “zones grises” com a àrees de incertesa i incomoditat, a través de les quals, problematitzar la experiència de aprenentatge com un esdevenir, atenent així al joc d’interessos, als dilemes emergents, als temps i els ritmes de treball, i a les complexitats intrínseques de les nostres pràctiques docents. En aquest article donem compte del treball d’investigació vinculat a dos contextos en concret: per una banda, l’àmbit de l’assignatura de Sociologia de l’Art al Grau de Conservació i Restauració de Béns Culturals, i, per una altra, el curs de La Cultura Digital i Visual als Processos Socioformatius del Grau de Pedagogia. A partir d’una metodologia basada en la construcció de relats docents, la intervenció en Forums del Campus Virtual, i les converses a l’aula, van emergir temes vinculats a: les conseqüències que comporta negociar les formes de treballar entre estudiants i docents, els ritmes d’aprenentatge, la durada de les assignatures i l’avaluació entesa com un procés reflexiu entre els subjectes que aprenen.

  13. Sostenere le produzioni cinematografiche: vantaggi fiscali e di immagine per gli investitori / Sustaining cinematographic productions: fiscal and image opportunities for investors

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    Katia Giusepponi

    2016-05-01

    Full Text Available Questo contributo è focalizzato su organizzazioni non appartenenti al settore cinematografico, osservate nel loro ruolo di investitori esterni. L’importanza del valore collettivo di sostenere le produzioni cineaudiovisive è alla base del presente lavoro. Tuttavia la nostra attenzione è qui rivolta, da un lato, a studiare i vantaggi dell’investimento per l’azienda esterna, dall’altro, ad analizzarne i rischi nella prospettiva di una sempre più chiara consapevolezza di scelta. Dall’analisi di strumenti, dinamiche e dati emergono opportunità rilevanti per l’azienda, insieme a condizioni importanti per utilizzarle con successo. È essenziale che l’organizzazione proceda senza improvvisare, curando, da un lato, un approccio alla pianificazione e alla dettagliata valutazione del progetto, dall’altro, flessibilità e apertura nelle interazioni con gli altri interlocutori, interazioni che devono essere orientate al raggiungimento dell’equilibrio migliore a livello collettivo e individuale. Soprattutto, è necessario che l’azienda proceda nel contesto di un percorso strategico solido e coerente, perché un progetto di film può valorizzare l’identità aziendale ma non risolvere incertezze a questo riguardo.   This contribution focuses on organisations that are not in the cinema industry, studied in their role as external investors. The importance of the collective value of sustaining cine audio visual productions is at the basis of this work. Nonetheless, our attention is oriented, on one hand, to study the investment advantages for the external organization, on the other, to analyse the risks of this investment in the perspective of an increasingly clear choice. From the analysis of tools, dynamics and data, relevant opportunities for the organisation emerge, together with important conditions for their successful implementation. It is essential that the organization proceed without improvising, following, on one side, an

  14. L’insegnamento della lingua e letteratura italiane a Cuba.

    Directory of Open Access Journals (Sweden)

    Mayerìn Bello Valdés

    2009-12-01

    Full Text Available Normal 0 14 MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabella normale"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman";} Nel suo articolo l’autrice ricostruisce la storia dell’insegnamento delle lingua e della letteratura italiane a Cuba dal Novecento ai giorni nostri, e fornisce una ricca documentazione sui corsi di italiano, sugli studi e  sulle opere più importanti pubblicate a Cuba sulla nostra letteratura e sulle manifestazioni realizzate per la diffusione della cultura italiana nel paese. In particolare riferisce dell’importante ruolo svolto dalla rivista “Cuadernos de italianística cubana” – e dalle istituzioni accademiche e culturali che ad essa fanno riferimento – nel campo della ricerca linguistica, della glottodidattica, dello studio della cultura italiana nelle sue diverse manifestazioni, tra cui la musica e l’opera lirica, e nella diffusione dell’italiano attraverso specifici programmi televisivi.  Normal 0 14 MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabella normale"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman";} In her article the author reconstructs the history of Italian language and literature teaching in Cuba from the Nineteen Hundreds up to the present and provides a wealth of documentation on the Italian courses, studies and the most important works published in Cuba on our literature, as well as on events organized to spread Italian culture throughout the country.  In particular

  15. Landscape and vegetation change on the Iberian Peninsula during the Roman Epoch - A reconstruction based on Geo-Bioarchives

    Science.gov (United States)

    Schneider, Heike

    2010-05-01

    Archaeological investigations expect that first strong landscape changes on the Iberian Peninsula based on Roman Occupation (Schattner 1998, Teichner 2007). Actual sedimentological investigations in flood plains, lagoons and estuaries do not reflect this development. They often show a decrease in sedimentation during this period (Thorndycraft & Benito 2006 a/b). In contrast analyses on sediments from roman dams (Hinderer et al. 2004, Solanas 2005) document massive erosion processes. The aim of this presented project is to reconstruct the effects of the roman land use system on vegetation and landscape development. Therefore different Geo-Bioarchives on several sites of Portugal and Spain - estuaries, palaeoriver channels and roman dams - are actually investigated with a high temporal resolution using palynological and sedimentological methods. First results show, that the anthropogenic impact starts clearly before roman time with an peak in human activity during Iron Age (Schneider et al. 2008). During the roman occupation phase different effects are visible. The inland areas document a massive increase in vegetation change, while the coastal areas were stronger developed before and show only slightly and very local changes in land use and vegetation. References Hinderer, M., Silva C. & J. Ries (2004). Erosion in zentralen Ebrobecken und Sedimentakkumulation in Talsperren. GeoLeipzig 2004, Geowissenschaften sichern Zukunft. - Schriftenreihe der Dt. Geol. Gesell. 34. Schattner, T.G. (1998): Archäologischer Wegweiser durch Portugal.- Kulturgeschichte der antiken Welt 74. Mainz. Schneider, H., Höfer, D., Trog, C., Daut, G., Hilbich C. & R. Mäusbacher (2008): Geoarcheological reconstruction of lagoon development in the Algarve Region (South Portugal). Terra Nostra 2008/2, Abstract Volume 12th IPC: 248. Solanas, O.L.-P. (2005): El Aterramiento del embalse romano de Muel: Implicaciones para la evolución de la erosióy el uso de los recursos hidricos en el valle del

  16. Identity And Access Management e Federazione

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    Virginia Calabritto

    2012-07-01

    Full Text Available ItLa rete telematica è in costante crescita e così i servizi online che, in modo sempre più penetrante, rappresentano un aspetto della nostra quotidianità. I servizi in rete si distinguono in servizi ad accesso libero e servizi ad accesso controllato. Ogni giorno studenti, ricercatori e docenti accedono a contenuti e servizi (risorse ad accesso controllato con modalità diverse, la più diffusa è l'utilizzo dell‘informazione utenza/password, informazione diversa per ciascuna risorsa. Da questo punto di vista l’ampia disponibilità di risorse in rete crea all’utente, ma non solo a lui, diversi problemi, non ultimo quello della memorizzazione di un numero sempre più ampio di coppie utenza/password.L’articolo è teso ad illustrare, nel dettaglio, scenario e problematiche per passare quindi ad accennare alle tecnologie che possono costituire una soluzione, ovvero, l'Identity Management, il Single Sign On e le federazioni di infrastrutture di autenticazione e autorizzazione e, quindi, a degli esempi tra cui IDEM, la prima federazione italiana di Infrastrutture di Autenticazione e Autorizzazione, che coinvolge gli enti della comunità scientifica ed accademica e i fornitori di servizi.EnThe Internet is constantly growing, therefore on-line services, are becoming part of our daily life in a more and more pervasive manner. The network services are divided into two types of access: free access and controlled access. Every day students, researchers and teachers access content and services (resources through controlled access using different modes, e.g using user / password information which is different for each resource. From this perspective, the large availability of networked resources generates many problems for the users, last but not least the inconvenience of storing an increasing number of user / password.The article aims to illustrate, in detail, the context and the problems related to the management of a digital identiy in the

  17. The wild heart of a wild land. Tra le Alpi albanesi sulle orme di Mary Edith Durham

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    M. Genesin

    2012-08-01

    Full Text Available ENIn 2007 we decided to follow the same route through northern Albania which was covered almost 100 years ago by the victorian traveller Mary Edith Durham, author of the books High Albania and Some Tribal Origins, Laws and Customs of the Balkans. The journey described in High Albania was the culmination of seven years of regular Balkan travels during which she was rewarded with insights into north Albanian life denied to all previous travellers. Unlike her other expeditions in the Balkans, her journey in northern Albania was an existential experience which deeply affected Durham’s perception of the tribespeople’s world and marked a turning point in her life. In the second part of the article some ethnographical aspects which were pointed out by Durham and are still alive in those regions are dealt with. Keywords: Balkan Studies; Cultural Studies; Ethnography; Mary Edith Durham; Albania  ITNel 2007 abbiamo deciso di organizzare una spedizione a carattere linguistico e etnogrfico nell’Albania settentrionale sulle orme dell’itinerario percorso quasi 100 anni prima dalla viaggiatrice vittoriana Mary Edith Durham, autrice dei volumi High Albania e Some Tribal Origins, Laws and Customs of the Balkans. L’itinerario descritto in High Albania coronò setti lunghi anni di esplorazioni balcaniche nel corso delle quali l’autrice riuscì a penetrare nella vita della popolazione locale, un importante esperienza che era invece mancata a tutti i precedenti viaggiatori. A differenza dagli altri viaggi precedenti nei balcani, quello nell’Albania settentrionale costituì un esperienza esistenziale che segnò profondamente la percezione della Durham del mondo delle alpi albanesi e rappresentò una svolta nella sua vita. Nella seconda parte dell’articolo sono illustrati alcuni fenomeni di carattere etnografico che furono rilevati dalla Durham e che, con nostra grande sorpresa, abbiamo potuto riscontrare sul campo nel corso della spedizione.

  18. Book review. La forma degli animali. Adolf Portmann

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    Manuel Graziani

    2013-09-01

    Full Text Available Nel 1931 il biologo Adolf Portmann era già talmente noto a livello internazionale per le sue ricerche da guadagnarsi la cattedra in zoologia nell'università della sua città natale, Basilea, all'età di appena 34 anni. All'attività di docente universitario ha sempre affiancato un'originale riflessione sul significato delle scienze della vita, imponendosi come una delle figure chiave nel dibattito tra biologia teoretica, estetica e antropologia filosofica. La forma degli animali, la sua opera più celebre, si pone al confine tra varie discipline e conserva un grande interesse ancora oggi che il dialogo tra estetica e biologia si è fatto nuovamente intenso. Pubblicata nel 1948 e in forma ampliata nel 1960 (da cui deriva questa prima edizione italiana a cura di Pietro Conte l'opera rappresenta il frutto più maturo delle sue ricerche "interdisciplinari".Un saggio che nasce dall'insoddisfazione nei confronti dei paradigmi scientifici consolidati e che ripropone l'idea morfologica in biologia sulla scorta del pensiero di J. W. Goethe il quale affermava che "tutto ciò che è deve anche dar cenno di sé e mostrarsi". Adolf Portmann è un convinto sostenitore che dalla forma si possano dedurne le complessive caratteristiche interne ed esterne degli animali. Secondo questa prospettiva la peculiare fisionomia dell'organismo dipende dalla congiunzione delle sue parti e dalle loro reciproche funzioni. Tuttavia l'autore non vede nello studio della forma l'alternativa al funzionalismo quanto, piuttosto, il suo necessario bilanciamento come dichiara nell'introduzione: "… per giungere alla conoscenza della vita animale di strade ce ne sono molte, e tutte possono contribuire ad arricchire la nostra esperienza. Questo lavoro si occupa della forma degli animali e si propone di mettere in luce la peculiare natura dell'aspetto visibile. Ci sono persone che si dedicano allo studio degli animali, conoscono moltissime specie, hanno imparato centinaia di nomi e

  19. Estimulant la creativitat i l’esperit crític dins de l’escola a través de la robòtica i la intel·ligència artificial: un cas d’estudi al sud de l’Índia

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    Eduard Muntaner-Perich

    2012-01-01

    Full Text Available En el món ràpidament canviant d’avui en dia cada cop és més evident que l’èxit no està només basat en què sabem o quant sabem, sinó en la nostra habilitat per pensar i actuar de manera creativa. Malauradament, en la majoria dels casos els models d’aprenentatge tradicionals de les escoles no solen estar enfocats a desenvolupar el pensament creatiu. Aquest problema s’accentua encara més als països en vies de desenvolupament, on la creativitat ben utilitzada podria convertir-se en una eina fonamental per reduir la pobresa i en un motor important per al desenvolupament humà sostenible. Aquest article descriu un projecte pilot finançat per la Universitat de Girona, que combina innovació educativa i cooperació al desenvolupament, i que s’ha dut a terme a Shanti Bhavan, una escola rural del sud de l’Índia. El projecte, basat en la teoria del construccionisme, ha consistit en uns tallers en els quals, a través de les tecnologies de la informació i la comunicació (concretament treballant la robòtica i la intel•ligència artificial, s’ha estimulat la creativitat i l’esperit crític dels nens. A més, simultàniament i a través del joc i l’exploració, s’ha fet un reforç no formal de les assignatures que plantegen més problemes a l’Índia rural. L’objectiu a llarg termini és que aquests nens esdevinguin agents del canvi, creatius i innovadors, de les seves pròpies comunitats, i que, compromesos amb la seva realitat social, siguin capaços de proposar noves alternatives per millorar la seva qualitat de vida i engeguin projectes per crear riquesa en els diferents àmbits socials. Els resultats són sis tallers executats satisfactòriament, amb la continuació del projecte assegurada i amb el disseny d’un model que permetrà reproduir el projecte en altres indrets. Aquest article fa un resum del projecte, dels resultats, de les lliçons apreses i dels treballs futurs.

  20. Il Gambling Compulsivo: rilevanza epidemiologica

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    A. Coacci

    2003-05-01

    nella stima dell’impatto socio epidemiologico della condizione studiata, la nostra ricerca rappresenta un primo tentativo di quantificare un fenomeno che accede alla considerazione del Piano Sanitario Nazionale come “Dipendenza” tra le più rilevanti.